text:
Follow ACORD on social media
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Keynote speakers include Jared Cohen of Google Ideas and Platon, an award-winning portrait photographer.
Reserve your ACORD2015 booth today.
ACORD2015 is a global summit focused on how data and technology will address the challenges and opportunities we face today…and tomorrow.
ACORD is currently accepting sponsors for our 2015 event.
ACORD2015 will take place at the beautiful Boca Raton Resort & Club.
Please join us for our networking events.
ACORD2015 presents engaging speakers who will challenge established conventions and open your mind to new ideas and approaches. They may come from diverse backgrounds. They may have chosen unusual career paths. But we're sure their unique narratives will resonate and give you inspiration that you can apply to your universe. Google Ideas founder Jared Cohen and legendary portrait photographer Platon are two of the most innovative and in-demand thinkers and speakers in the world today, and we're proud to bring them to you.
The core of ACORD2015 is three days of knowledge that you can put into action. Whether it's deep dives into ACORD Standards and Architecture, continuing education and professional development, or the latest on the technology and business horizons, you'll find sessions to fill you up with fresh ideas and help take your career to the next level.
Ace Boot Camp
ACE Boot Camp comes to ACORD 2015! Become an ACORD Certified Expert this year.
ACE Boot Camp is an intensive refresher for ACORD Standards Implementation that includes ACE exam preparation and testing. Join us in November at our conference and see if you have what it takes to become an ACORD Certified Expert.
You've got solutions. We've got the people who need them. In the exclusive ACORD2015 Innovation Center, we're creating new opportunities to showcase your products and services. Or increase your visibility and raise your profile with a sponsorship. Let us design a package for you that puts your name and logo in front of influencers and decision makers. Opportunities are knocking now. Grab one before it's gone.
Ideas wanted. ACORD2015 is the place for innovation, for bold ideas, for sharing, debating and discussing the ideas that will move our industry forward to the future. If you've got what it takes, we want to hear about it. Submit your session and speaker proposals today and be more than a part of the movement – be a leader.
My career continues to grow positively. I can thank ACORD conferences for keeping the fire lit underneath me and engaging to better serve my clients."
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Top O' Michigan Insurance
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Boston Software
I've been working with the standards for 27 years, and still, I learned some more."
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NxTech
It's like a language in the insurance industry. ACORD is widely used by a lot of insurance carriers, and you need to understand how those ACORD Standards work. So it definitely adds value to me as a person."
Pragnesh Bhate
In today's world you can't do a business case on efficiencies. You have to do it on new innovations. So you really have to be forward-thinking, and you have to get in front of some of the technology that's out there."
Pat Hamilton
This new generation that's grown up with mobile phones, social networks, with online platforms - how will they think about making decisions about insurance? I think it's a wake-up call for anyone in the traditional insurance business to re-think their business."
Mike Walsh
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It's who you know. And it's also how well you know them. We've built in plenty of time and space for you to make new connections and strengthen the bonds with old friends. Nothing compares to sharing a smile, a cup of coffee and a conversation in person. See and be seen at ACORD2015.
Monday, November 2, 2015 - Wednesday, November 4, 2015
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Michell Merritt


text:
Q: Entity Migration. Could not drop constraint. See previous errors Here is the code that produce this error. I've tried solution for renaming the AddForeignKey but the error is same.

'PK_dbo.Item' is not a constraint.
  Could not drop constraint. See previous errors.

Can you suggest some solution?
public override void Up()
{
    DropForeignKey("dbo.AddGallery", "item_fk_id", "dbo.Item");
    DropForeignKey("dbo.ExtraFieldValue", "item_fk_id", "dbo.Item");
    DropPrimaryKey("dbo.Item");
    AddColumn("dbo.Item", "id", c => c.Int(nullable: false, identity: true));
    AddPrimaryKey("dbo.Item", "id");
    AddForeignKey("dbo.AddGallery", "item_fk_id", "dbo.Item", "id");
    AddForeignKey("dbo.ExtraFieldValue", "item_fk_id", "dbo.Item", "id");
    DropColumn("dbo.Item", "item_id");
}

public override void Down()
{
    AddColumn("dbo.Item", "item_id", c => c.Int(nullable: false, identity: true));
    DropForeignKey("dbo.ExtraFieldValue", "item_fk_id", "dbo.Item");
    DropForeignKey("dbo.AddGallery", "item_fk_id", "dbo.Item");
    DropPrimaryKey("dbo.Item");
    DropColumn("dbo.Item", "id");
    AddPrimaryKey("dbo.Item", "item_id");
    AddForeignKey("dbo.ExtraFieldValue", "item_fk_id", "dbo.Item", "id");
    AddForeignKey("dbo.AddGallery", "item_fk_id", "dbo.Item", "id");
}

A: I believe the primary key no longer exists and this is why it cannot be dropped.

A: I find an solution for this problem. Because I've trying to change the name of the existing primary key name, I encountered an error while migration because that primary key was referenced to other tables. So the solution was simply to add [Column("id")] DataAnnotation and than make the migration. Column name of the primary key was successfully changed without any error.

A: In my case, I used "Code first from database" approach. I had DB with my own foreign/primary key names different from ones the migration expects. So the migration just couldn't find relationships with such names. I had to explicitly name these relationships in dropping:
DropForeignKey(string dependentTable, string name);
DropPrimaryKey(string table, string name);

But be aware: using this approach, you need to explicitly modify Up and Down methods. It means, if you don't redefine Down() to match new Up method (using the previous FK/PK names) then if you go back on migrations, initial Down() will produce keys with its own names and Up() will need to have initial structure before self modifying, unless it won't find keys with such names when you use update-database again.

redpajama_set_name: RedPajamaStackExchange


Are you thinking about starting your own beauty routine? Are you unsure about how to get started? Do you know which products to use to achieve your desired look? If you simply do not know the answers to such questions, the article that follows will be very useful.
Keep some make-remover in your purse or make-up bag. You'll need to have them at your fingertips in case you make an error when applying your makeup. This is something anyone can do. Keep these in your arsenal at all times.
If you regularly use hot tools on your hair, make sure you allow your hair to have a break from them every few days. Heating implements such as curling irons, flat irons, heated curlers and blow dryers damage your hair badly. If you must use them, at least give your hair a little time to recover between uses.
If you have the money, you may want to get another set of cosmetics that you normally use, like foundation, lipstick or lotion. Keep these products in places that you are always present, such as your office. This can give you a strong backup plan if you are to forget a step when in a rush.
If you are insecure about having large ears, wear a hairstyle that is long enough to cover them. Do not put your hair up in a ponytail as this will accentuate them.
Milk of magnesia is a great mask for getting rid of oily skin. It can be found at drugstores for an affordable price. Target your oiliest areas by gently wiping with a cotton ball soaked in the milk of magnesia. After allowing your face to dry for around ten minutes, then rinse away the medication. You should do this nightly.
You can replace pricey designer skin care products with alternatives like soft washcloths, pure castile soaps, Aloe Vera gel for moisturization and even white vinegar or witch hazel for mild toning. You'll see wonderful results with these natural products. If your skin requires additional moisture above what you can get from aloe, add a bit of vitamin E. If you want a toner that is medicated, use tea tree oil.
Is creating a beauty routine of your own something you understand how to do? Are you ready to start? Can you chose the beauty secrets that are right for you? If you can now provide an answer to these questions, then you have read and understood the previous tips and are ready to make beauty work for you.
This entry was posted in Beauty and the Beast and tagged beauty routine.


C.14904 - Move right in to this immaculate, completely remodeled town home. Kitchen features with new white cabinets, granite counters and white mother-of-pearl tile backsplash. 20" tile throughout the living area and tile on the stairs for easy care. ½ bath conveniently located off the living room has been remodeled. Custom decorative tile in the entry. Upstairs you will find the washer and dryer and new vanity in the bathroom. San Marco Villas is conveniently located in the center of the island just a short distance to shopping, restaurants and less than a mile to the beautiful white, powder sand beach Marco is famous for. Condo offers large pool and sun area along with a spa.


text:
It has been a long and raucous courtship, but the Democratic Party has finally popped the question and now the onus is on Chief Executive Donald Tsang and his team to say "I do" or accept that the wedding is off.
The DP has said it will support the Government's political reform package - notwithstanding the party's many reservations about the slow pace of democratization - provided one relatively modest amendment is made to it. The change the party is requesting concerns the arrangements for electing the six (one existing, five proposed additional) Legislative Council Members from among the District Councilors.
The Government scheme says candidates for these seats must themselves be DC members, nominated by fellow DC members and only such persons can vote. The DP is accepting the eligibility and nomination arrangements - so as to stay within the definition of Functional Constituencies -- but asking for the actual voting to be open to all Hong Kong registered voters. This change is fully in line with the requirement for measured and orderly progress in pursuit of the move towards direct elections.
In a live radio show last week DP spokesman Lee Wing Tat made clear that while the party would also be seeking some reassuring remarks on the record from the Hong Kong authorities about its intentions for further reform in 2017 and 2020, the voting arrangements for the DC seats would be the only change it would seek in respect of the resolution to be voted on later this month which will shape the 2012 electoral arrangements.
As is traditional, the bride is playing hard to get right up until the last minute. This is understandable. After all, if the Government were to make such a concession now, who knows what other items might be added to the dowry before the scheduled vote on 23 June.
But decision time is approaching and cannot be postponed if the Government is to retain any credibility. The issue is simple: with the DP votes the reform package will pass, without them it won't.
So with the DP's proposed amendment a matter of public record, will the official side concede - gracefully or grudgingly doesn't really matter - or will it continue on the path to certain defeat?
If the nuptials were only being decided upon by the couple themselves then the most likely outcome would be a happy wedding. After all, both sides still carry too many scars from 2005 when they left each other standing at the altar to want to repeat the experience.
But just as in real life a marriage involves more parties than the couple at centre stage, so in the case of Hong Kong's political development the Father of the Bride lurks close by. From his Liaison Office home in Sai Wan he is not hesitating to make known his own views on what terms would be acceptable to win his daughter's hand. In effect he is saying that what is already on the table is all there is going to be. He is insisting publicly that the groom back down, but that only makes the groom feel all the more that his democratic manhood is on the line.
Are we headed irrevocably for another impasse? Is there no way forward?
In a real life situation of course the pressure would now be all on the bride to make up her mind how she saw her future. Give up her beau and start looking for another mate daddy might approve of? In the political context, there is no other potential partner. Resign herself to being an old maid and spending the rest of her life on the shelf? That would mean the Tsang administration was condemned to two years of irrelevance and would leave a terrible legacy for the next Chief Executive. Or make a tearful last minute attempt to sweet talk Dad? Or even threaten to elope?
In Hong Kong's situation, the last is the only real option left. Our Chief Executive needs to be bold and take his own advice: he needs to Act Now.

redpajama_set_name: RedPajamaCommonCrawl


- The city of Poolesville offers amazing schools. All of them ranked very well!
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- Prices for a nice single-family home in Poolesville start at $600,000. Plus, you have the option to buy a house with a big backyard. Homes with around half an acre lot are not uncommon.
- Poolesville High school offers many Magnet programs that my kids can have access to.
- Poolesville is very quiet and residential. It offers a country-living.
- Poolesville has many farms that sell organic produce.
- As a Real Estate Agent, I believe that Poolesville will continue increasing in value.
If you are considering moving to Poolesville, please give me a call at 301-366-9890. I am a one-stop shop! I will not only be able to show you homes in the city of Poolesville but I can show you homes in your price range all around the area including (but not limited) to New Construction, foreclosures, short sales, auctions, etc. I could show you homes in Montgomery County, Frederick County, Howard and Prince Georges County.


text:
Hall of Religion - Expo Chicago 1933
© Kaufmann & Fabry Co
Modern in design, though ecclesiastical in atmosphere, the Hall of Religion within the exhibition is highly significant of the efforts made to present a well-balanced programme.
Believing that progress is impossible without religion, a committee was appointed by Rufus C. Dawes, president of the Exposition, five years ago to construct a religious display that would be in harmony with the theme of a century of Progress.
The Hall of Religion, located just southeast of the General Exhibits group, is the result.
This large, imposing building, with its beautiful stained glass windows, pipe organ, assembly rooms, small and many other interesting features, presents an expression of courtesy and cooperation between the various religions rather than competition.
The spirit of peace is the spirit of the hall, and the spirit of belief is submerged in human service.
The building was built with contributions from some Protestant, Jewish and other denominations. It contains a chapel for meditation and a meeting room with a capacity of about 500 seats for small religious conferences.
There are many posters presenting religious organisations.
The walls of the rotunda are covered with decorative texts of the words of such great religious leaders as Jesus, Buddha and Isaiah.
Priceless religious antiquities, including some of the earliest printed Bibles, are displayed in another part of the building.
The display of some stained glass windows, including the most prominent of those recently forged by Charles Connick of Boston for the Presbyterian Church in downtown Pittsburgh, is more than attractive.
Among the most prominent churches participating in the exhibition are Jewish, Lutheran, Methodist, Presbyterian, Episcopalian, Baptist and Christian Scientist. The Christian Science Monitor, the church's daily newspaper, has its own building nearby.
©Official Guide Book 1933-1934


text:
Find cheap Aer Lingus tickets on eDreams
Smart combination of flights
Secure flight booking
Aer Lingus flight deals to all destinations
Newark - Nj - Budapest
Chicago - Dublin
Brussels - San Diego
Madrid - Seattle
Orlando - Manchester
Chicago - Amsterdam
Prague - Dublin
Flying with Aer Lingus
Aer Lingus was founded in 1936 and is the national flag carrier of Ireland. It is headquartered in Dublin and its main hub is Dublin Airport. Aer Lingus operates a fleet of Airbus aircraft, including A319, A320, A321, and A330 planes. The average age of the planes in the Aer Lingus fleet is 8.9 years. All transatlantic Aer Lingus flights on A330 aircraft offer in–flight WiFi and personal entertainment systems. Aer Lingus flies to more than 75 destinations in Europe, North America, and northern Africa. Since 2013, Aer Lingus has carried more than 10 million passengers per year. It also has codeshares with Air Canada, British Airways, Etihad Airways, JetBlue Airways, KLM, and United Airlines.
Aer Lingus offers online check–in and airport check–in. Online check–in is usually available between 2 and 30 hours before the scheduled flight departure time. Online check–in is limited to between 2 and 24 hours before the scheduled departure time for travel to/from New York (JFK), Boston, Chicago and Orlando. For some other airports, the online check–in is limited to 4.5 and 30 hours before the scheduled departure time. Please consult the Aer Lingus website to be certain of the options. For the following select European routes, Aer Lingus offers 30 day advanced web check–in: flights between Ireland and the United Kingdom; flights between Ireland and Austria, Belgium, Bulgaria, Croatia, Czech Republic, Finland, Germany, Greece, Hungary, Italy, Lithuania, Poland, Portugal, Romania, Spain, Sweden, Switzerland, Turkey; flights between Ireland and Lyon, Nice, Paris, Toulouse, Perpignan, Marseille, Bordeaux; flights from Ireland to Amsterdam, Rennes, and Agadir.
For airport check–in, Aer Lingus recommends arriving 3.5 hours before long–haul routes and 2.5 hours for short–haul routes within Europe. Check–in counters close 75 minutes before departure for long–haul flights (60 minutes for business class travel), 45 minutes before departure for short–haul routes within Europe, and 30 minutes before departure for flights departing Belfast City Airport. Note: the Dublin Airport now offers "evening before" check–in for Aer Lingus flights departing between 6:00am and 8:00am. This allows passengers to check–in at the airport from 4pm–8pm the evening before their flight.
Boarding Information
All passengers are advised to be at the boarding gate at least 30 minutes before the scheduled departure time. Passengers traveling to/from Rome or Amsterdam are advised to arrive 40 minutes before and passengers traveling to/from the USA are advised to arrive 45 minutes before. Passengers who arrive late to the boarding gate may be denied boarding. Pre–boarding is offered for passengers who require special assistance, such as passengers who are visually impaired or require the use of a mobility device. For pre–boarding, passengers should contact the Aer Lingus customer staff at the boarding gate. Priority boarding is offered to passengers traveling in business class and Gold, Prestige, and Elite members in the Aer Lingus Gold Circle frequent flyer program.
Frequent Flyer Information – Gold Circle
Aer Lingus offers a frequent flyer program called Gold Circle. Members can earn points by traveling with Aer Lingus or on partner airlines. The number of points earned per flight depends on the booking class, with bonuses offered for business class travel. Points can be redeemed for reward flights on Aer Lingus or partner airlines, or for upgrades to business class on Aer Lingus. The Gold Circle program has three tiers for frequent fliers: Gold, which is received by earning 2,400 in the previous 12 months; Prestige, which is received by earning 4,800 in the previous 12 months; and Elite, which is received by earning 8,400 in the previous 12 months. Passengers who have attained this level of membership enjoy additional perks such as priority check–in and boarding, lounge access, and flight upgrades.
Hand Baggage Allowance
All passengers are permitted one carry–on bag and one carry–on personal item such as a briefcase, purse, laptop bag, or diaper bag. The maximum size for the carry–on bag is 21" H x 15" L x 9" W (55 x 40 x 24 cm); maximum weight is 22 lbs (10 kg). The maximum size for the personal item is 10" H x 13" L x 8" W (25 x 33 x 20 cm). Baggage exceeding the carry–on size and weight limits will have to be checked and fees will apply.
Note: carry–on bag size and weight requirements differ for Aer Lingus Regional services. Maximum size of a carry–on bag for regional service is 18" H x 13" L x 8" W (48 x 33 x 20 cm) with a maximum weight of 15 lbs (7 kg).
Note: pets are not permitted to travel onboard any Aer Lingus aircraft. Pets in carriers with proper documentation and which meet other travel requirements will be placed in the aircraft's hold. All pets must be booked through Aer Lingus Cargo. Please refer to the Aer Lingus website for specific requirements and conditions.
For travel within Europe, checked baggage fees apply for all economy fares. (See below for exceptions). Fees vary according to the item's size, the route and the season. Fees are generally lower when baggage is booked online, being often up to 50% higher for baggage booked in the airport. Passengers may travel with up to three checked bags. Checked baggage fees are partially determined by item size, which is divided into four categories: small (maximum weight of 33 lbs / 15 kg) medium (maximum weight of 44 lbs / 20 kg) large (maximum weight of 55 lbs / 25 kg) extra–large (two bags with a combined maximum weight of 88 lbs / 40 kg). Note: Aer Lingus will not accept individual bags weighing more than 70 lbs / 32 kg.
Exceptions to checked baggage fees: Passengers traveling on a plus/flex fare are allowed one free medium sized bag. For transatlantic travel on Aer Lingus, all passengers are entitled to one complimentary piece of checked baggage. Passengers who book an infant travel within Europe can check one collapsible stroller free of charge. Passengers who book an infant travel to/from North America receive an additional infant checked baggage allowance of 22 lbs (10 kg). The maximum size is 62" (158 cm) in combined dimensions (length + width + height) and the maximum weight is 50 lbs (23 kg). These passengers are also able to check one collapsible stroller free of charge. Passengers traveling in business class or first class are permitted up to three complimentary pieces of checked baggage with a maximum combined weight of 150 lbs (69 kg). Fees apply for additional pieces of checked baggage or overweight baggage. Note that the maximum weight for any checked item is 70 lbs (32 kg). Medical equipment such as wheelchairs, dialysis machines, or defibrillators can be checked for free but passengers must notify the airline at least 48 hours before the scheduled departure time. Please check with the airlines for special preparation requirements concerning such electric and battery operated assistive devices.
Aer Lingus latest reviews from customers
Total reviews based on: 25
Dublin - Gatwick ( DUB - LGW )
Date 2018-07-13 City USA Age 31-50 Class Economy
Excellent experience. Would use the airline again.
Fiumicino - Dublin ( FCO - DUB )
Date 2018-05-02 City Age Class Economy
Everything was good except the buying of food in the aircraft it was really my first experience to pay for the food in the aircraft since i have been traveling.
Dublin - Glasgow Scotland ( DUB - GLA )
Too little space to sit
Dublin - Turnhouse ( DUB - EDI )
Seats are way too small. Whose back is only 20 inches wides? This is not Asia.
Newark - Nj
Gatwick - Newark International Airport ( LGW - EWR )
They left my bag in London! 3 days without my bag and counting.
Miami International Airport - Dublin ( MIA - DUB )
I had to travel to Ireland for my aunt's funeral. I traveled the same day I booked the flight. I thought the price was horribly expensive (approx. $1950). I could not find a mechanism for attempting to obtain a bereavement fare if such an option still exists. Other than that the flight(s) were fine. Nice people working for the company.
Knock Intl - Gatwick ( NOC - LGW )
none provided
not bad for a short hop
Zurich - Dublin ( ZRH - DUB )
Plane was noisy, service mediocre
Lisboa - Dublin ( LIS - DUB )
Date 2018-11-20 City Ireland Age 51-70 Class Economy
The flight to Dublin was delayed by about an hour and the cost of the ticket was too expensive.
Dublin - Heathrow ( DUB - LHR )
This was a horrible experience. The booking stated aier lingus. After wasting 20 mins with them we find out it's a british airways flight. Then we find out it's overbooked and we had to wait until.last.minute and rush though security. You need to detail the correct airlines.
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text:
May 18, 2014 by David Crumm
I was a Little Golden boy. Millions of Baby Boomer girls and boys were like me—raised on this revolutionary series of affordable, high-quality picture books for children. You may have a favorite. Mine is Wiggles, released in 1953 with gorgeous illustrations by Eloise Margaret Wilkin, who sometimes was called "the soul of Little Golden Books." She used a variety of media to produce luminous illustrations—often depicting children at home in town and country. Wiggles was about a city boy who went to live in the country and discovered all sorts of wonders in the farmland surrounding him. I loved the book because several scenes evoked Robert Frost poems that I heard my parents read aloud in our home. One illustration shows apple picking; another shows a calf with its mother that is reminiscent of Frost's "The Pasture." When I learned to read and finally could read books by myself, I carried vivid images in my head from Eloise Wikin and Little Golden Books. They were—and are—images of harmony, hospitality and hope.
David Crumm
Little Golden Books (born 1942)
Click the cover to visit the book's Amazon page.
The post World War II revolution in children's literature, now known as Little Golden Books, sprang from roots that were sunk decades before the war. "Roots" is a good metaphor because these earlier efforts were regarded as tangled and dirty by the literary elite who ruled American libraries. The entire story is laid out—with lots of colorful pictures—in Golden Legacy: How Golden Books Won Children's Hearts, Changed Publishing Forever, and Became An American Icon Along the Way, by Leonard S. Marcus.
One root beneath the launch of Little Golden Books was the Artists & Writers Guild, formed in the 1930s to dramatically rethink the way books were produced. Borrowing a medieval-sounding name, these writers and artists were based in New York and intended to create a whole new collaborative process for rapidly producing books. They weren't interested in traditional literary gatekeepers—nor were those gatekeepers interested in their books, for the most part. Other pre-war taproots were pulp fiction, comic books and even Horatio Alger up-from-the-bootstraps novels. These were "popular" books in "cheap" editions and America's librarians scoffed at the whole mess.
Beautiful American-produced children's books already were redefining childhood before World War II—if you were part of a well-to-do family who could afford a $2.00 hardback copy of The Story of Babar, which first appeared in the UK and the US in 1933.
Everything about Little Golden Books was intended to democratize children's literature, starting with the price: a quarter. These books were fast, inexpensive and focused on connecting all families with quality picture books about real life, including American cities, towns, human families, animal families, occupations and modes of transportation. The publishing project also spanned much of the nation—joining Simon and Schuster in New York City with Western Publishing in Racine, Wisconsin.
A pilot group of a dozen Little Golden Books—starting with Three Little Kittens and including the famous The Poky Little Puppy—were published in 1942, but wartime shortages prevented the full-scale launch of the project until 1946. The first two volumes in the post-war series were New House in the Forest, illustrated by Eloise Wilkins and The Taxi That Hurried, illustrated by Tibor Gergely. A Hungarian refugee who made it to New York in 1939, Gergely went on to create the super-popular books Tootle, The Little Red Caboose and Scuffy the Tugboat.
America's librarians hated the whole idea of these upstarts who were intentionally bypassing their traditional pre-publication review process—and then were grabbing little eyes in drug stores, "variety stores" and "dime stores." The gatekeepers of children's literature favored fairy tale classics; they only bought "quality" editions and they encouraged the publishing of "timeless" stories for their institutional collections.
Librarians also turned up their noses at Lucy Sprague Mitchell, an educator who had tangled with library associations as far back as the 1920s. Mitchell became one of the major cheerleaders behind Little Golden Books. Earlier, she had founded an influential progressive school in Manhattan's West Village, called the Bank Street Nursery School. (Today, the school founded by Mitchell in 1916 has evolved into the Bank Street College of Education.) A veteran of national debates on the future of childhood education, Mitchell went after the critics of Little Golden Books full force.
In Golden Legacy, Leonard Marcus writes: "Arguing that young children were naturally curious about everyday modern life—airplanes, telephones, cities—and apt to be confused by the 'timeless' fairy tales librarians favored, Mitchell … went on to propose prototypes for a new kind of child-centered children's literature."
The project picked up another major educational ally in "Mary Reed, PhD," a name frequently associated with Little Golden Books although Mary herself remained largely in the background. She co-authored only two of the books, My Little Golden Dictionary in 1949 and Numbers in 1955. Mary, born in 1880 in a small town along the Susquehanna River, grew up to become a courageous scholar on the faculty of Columbia University's Teachers College. She bumped into the Writers & Artists Guild, which she immediately saw as a sign of cutting-edge creativity in media. That led to her connection with Little Golden Books. The savvy team recognized that Mary's "PhD" and her prestigious role at Columbia would trump the other gatekeepers among America's libraries who kept disparaging Little Golden Books. Mary agreed to review and comment on all Golden books, lending her name and that fancy "PhD" to what became a popular movement in households nationwide.
Children and their parents loved to collect Little Golden Books. They reshaped American childhood. One of the best ways to glimpse their cultural impact is through Diane Muldrow's new, Everything I Need To Know I Learned From a Little Golden Book. Muldrow is an editorial director at Little Golden Books and has written dozens of the stories herself.
In her preface to the new book, she describes the millions of American children who loved looking at the colorful covers of Little Golden Books while shopping with their families. If Mom or Dad agreed to buy one, "when you got the book home, you proudly scrawled your name on the inside front cover where it said: 'This Little Golden Book Belongs to …'"
"Little Golden Books were first published during the dark days of World War II," Muldrow writes. "They've been comforting people during trying times ever since—while gently teaching us a thing or two. And they remind us that we've had the potential to be wise and content all along."
(Originally published at readthespirit.com, an on line magazine covering religion, spirituality, values and interfaith and cross-cultural issues.)
Filed Under: North America


text:
Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data.
Int J Toxicol. 2009 Nov-Dec; 28(6):498-509.IJ
This report describes a physiologically based pharmacokinetic model for cyclohexane and its use in comparing internal doses in rats and volunteers following inhalation exposures. Parameters describing saturable metabolism of cyclohexane are measured in rats and used along with experimentally determined partition coefficients. The model is evaluated by comparing predicted blood and brain concentrations to data from studies in rats and then allometrically scaling the results to humans. Levels of cyclohexane in blood and exhaled air are measured in human volunteers and compared with model values. The model predicts that exposure of volunteers to cyclohexane at levels of 4100 mg/m(3) (approximately 1200 ppm) will result in brain levels similar to those in rats exposed to 8000 mg/m(3) (the no-effect level for acute central nervous system effects). There are no acute central nervous system effects in humans exposed to 860 mg/m(3), consistent with model predictions that current occupational exposure levels for cyclohexane protect against acute central nervous system effects.
Hissink AM
TNO Quality of Life, Zeist, The Netherlands.
Kulig BM
Kruse J
Freidig AP
Verwei M
Muijser H
Lammers JH
McKee RH
Owen DE
Sweeney LM
Salmon F
AlgorithmsAnimalsBrainCyclohexanesData Interpretation, StatisticalHumansMaleModels, StatisticalNo-Observed-Adverse-Effect LevelOccupational ExposurePharmacokineticsPulmonary AlveoliRatsRats, Inbred F344Rats, WistarSolventsSpecies SpecificityTemperatureTissue DistributionYoung Adult
Hissink, A M., et al. "Physiologically Based Pharmacokinetic Modeling of Cyclohexane as a Tool for Integrating Animal and Human Test Data." International Journal of Toxicology, vol. 28, no. 6, 2009, pp. 498-509.
Hissink AM, Kulig BM, Kruse J, et al. Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data. Int J Toxicol. 2009;28(6):498-509.
Hissink, A. M., Kulig, B. M., Kruse, J., Freidig, A. P., Verwei, M., Muijser, H., Lammers, J. H., McKee, R. H., Owen, D. E., Sweeney, L. M., & Salmon, F. (2009). Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data. International Journal of Toxicology, 28(6), 498-509. https://doi.org/10.1177/1091581809348718
Hissink AM, et al. Physiologically Based Pharmacokinetic Modeling of Cyclohexane as a Tool for Integrating Animal and Human Test Data. Int J Toxicol. 2009 Nov-Dec;28(6):498-509. PubMed PMID: 19966142.
TY - JOUR T1 - Physiologically based pharmacokinetic modeling of cyclohexane as a tool for integrating animal and human test data. AU - Hissink,A M, AU - Kulig,B M, AU - Kruse,J, AU - Freidig,A P, AU - Verwei,M, AU - Muijser,H, AU - Lammers,J H C M, AU - McKee,R H, AU - Owen,D E, AU - Sweeney,L M, AU - Salmon,F, PY - 2009/12/8/entrez PY - 2009/12/8/pubmed PY - 2010/2/18/medline SP - 498 EP - 509 JF - International journal of toxicology JO - Int J Toxicol VL - 28 IS - 6 N2 - This report describes a physiologically based pharmacokinetic model for cyclohexane and its use in comparing internal doses in rats and volunteers following inhalation exposures. Parameters describing saturable metabolism of cyclohexane are measured in rats and used along with experimentally determined partition coefficients. The model is evaluated by comparing predicted blood and brain concentrations to data from studies in rats and then allometrically scaling the results to humans. Levels of cyclohexane in blood and exhaled air are measured in human volunteers and compared with model values. The model predicts that exposure of volunteers to cyclohexane at levels of 4100 mg/m(3) (approximately 1200 ppm) will result in brain levels similar to those in rats exposed to 8000 mg/m(3) (the no-effect level for acute central nervous system effects). There are no acute central nervous system effects in humans exposed to 860 mg/m(3), consistent with model predictions that current occupational exposure levels for cyclohexane protect against acute central nervous system effects. SN - 1092-874X UR - https://www.unboundmedicine.com/medline/citation/19966142/Physiologically_based_pharmacokinetic_modeling_of_cyclohexane_as_a_tool_for_integrating_animal_and_human_test_data_ L2 - https://journals.sagepub.com/doi/10.1177/1091581809348718?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -
Grapherence [↓2]
Cyclohexanes
Models, Statistical
No-Observed-Adverse-Effect Level
Pulmonary Alveoli
Rats, Inbred F344
Rats, Wistar
Species Specificity
Model studies for evaluating the neurobehavioral effects of complex hydrocarbon solvents III. PBPK modeling of white spirit constituents as a tool for integrating animal and human test data.
Neurobehavioral effects of cyclohexane in rat and human.
A comparison of physiologically based pharmacokinetic model predictions and experimental data for inhaled ethanol in male and female B6C3F1 mice, F344 rats, and humans.
Genotoxicity of 1,3-butadiene and its epoxy intermediates.
Determination of age and gender differences in biochemical processes affecting the disposition of 2-butoxyethanol and its metabolites in mice and rats to improve PBPK modeling.
Development of a physiologically based pharmacokinetic model for propylene glycol monomethyl ether and its acetate in rats and humans.
Modeling the toxicokinetics of inhaled toluene in rats: influence of physical activity and feeding status.
Development of physiologically based pharmacokinetic model for methyl tertiary-butyl ether and tertiary-butanol in male Fisher-344 rats.
Predicting age-appropriate pharmacokinetics of six volatile organic compounds in the rat utilizing physiologically based pharmacokinetic modeling.
Physiologically based pharmacokinetic modeling of a ternary mixture of alkyl benzenes in rats and humans.


text:
Child Services Tort Reform Being Considered
Filed Under:Barahona, Barahona Tragedy, Child Care, Civil Cases, Community-Based Care Organizations, Florida Legislature, Lawsuits, Legislature, Nan Rich, Tort Reform, Torts
TALLAHASSEE (CBS4) – While the GOP-controlled Florida Legislature works on capping lawsuit awards for medical malpractice, lawmakers are also proposing capping damages that could be assessed against Florida's community-based care organizations.
Under the bills proposed in the Florida House and Senate, the most a child services provider could be forced to pay would be $500,000 per claim. Currently, the limit is at $1 million per claim.
The bill's sponsor in the House, Rep. Scott Plakon, told the News Service of Florida that the said the bill protects DCF due to the state agency outsourcing most of its services.
But, Democrats counter that in the wake of the Barahona tragedy, the caps would reduce the incentive for the contractors to do their jobs properly.
"The Barahona case is an example of why we need more accountability and responsibility in the foster care system, not less," Senate Democratic Leader Nan Rich told the News Service of Florida. "Limited liability would mean less. We are already seeing, as a result of the task force investigating the Barahona case, the lack of coordination, the lack of accountability as far as the performance indicators are concerned."
Former DCF Secretary George Sheldon said he understood the concerns behind the legislation, but doesn't support it.
"I just don't think it's the right thing to do," Sheldon told the News Service of Florida. "It really is overkill."
(© 2011 CBS Broadcasting Inc. All Rights Reserved. This material may not be published, broadcast, rewritten, or redistributed. The News Service Of Florida contributed to this report.)


Posted on October 13, 2015 by Matt Frazier / This entry was posted in Informative, Product Reviews and tagged firefly, firefly vaporizer, herbal, herbal vaporizer, vape, vaporizer. Bookmark the permalink.
A convection vaporizer allows your herb to be heated with hot air, and makes for one of the best herbal vaporizing options available. The Firefly vaporizer utilizes this style of heating, providing a clear smoke, with limited issues on smell or portability! It is a larger size vaporizer, similar in size to other herbal vaporizer options we have at the shop including the DaVinci and Ascent. The sturdiness on the Firefly Vaporizer can be felt almost immediately, and the design is also very sleek, combining simplicity with heavy duty efficiency!
To open the Firefly, simply lift the magnetic cover and access the herb chamber (picture below)! The "locking" mechanism ensures this piece will not slip as you enjoy a bowl. As with most herbal vaporizers, preparing finely ground herbs is important for allowing air to flow easily through to the mouthpiece below, where you'll enjoy a hit that is powerful, but clear. A transparent glass cover allows the user to see when their product is reaching the near end of rotation. Don't forget to grab an Octopus Glass Jar to store the leftovers for later use.
As you slowly pull, the power remains in YOUR hands as to how dense the smoke will be when inhaled!
Although the Firefly weighs in as the heaviest of our herbal vaporizer options, the size remains easily portable, resting comfortably in your palm. Once your bowl is done, the discreteness presents a myriad of options for putting away – stash in your pocket, or away on a shelf. It comes in vibrant red or smoky black. Fans of slimmer or pen-style vaporizers can still choose from our selection which includes the brand new PAX 2 and the Atmos Orbit!
A removable battery presents the option to stock up on batteries, keeping your charges going above and beyond and helping provide an excellent quality vapor. Long lasting power keeps you puffing all through the day, giving you that extra boost when you need it most.
When unboxing the Firefly Vaporizer, you'll find all the instructions you need to get started in a concise, fast to read manual, as well as a detailed guide to selecting the ideal temperature for your bowl. This vaporizer, like many of our others, allows you to easily switch the intensity of the heat for optimal smoking, meaning that you can get the most out of your herb while providing an optimal vaping experience to all types of vapers.


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Can HR have friends beyond its own team?
Sonali Chowdhury | HRKatha
HR cannot afford to remain aloof in an organisation nor can it toe the line when it comes to maintaining professional boundaries.
Human resource is one function in an organisation that cannot be confined to a role within its own department. It cuts across verticals, which calls for a personal connect at the employee level. Be it talent acquisition that may require generating leads within the teams, compensation management or redressal of employee grievances, HR holds critical and sensitive information about various departments. However, the proximity or friendship of the HR personnel with employees in the organisation can raise questions around its objectivity.
Considering its inherent human role, HR cannot afford to detach itself from its counterparts. Most HR leaders do not subscribe to such boundaries.
"HR should closely work with business, design people practices and also champion the cause of employees. HR has to remain part of the larger goals and requirements of businesses. HR in isolation is useless—a mere admin function," says Richard Lobo, executive vice-president & head-human resources, Infosys.
HR leaders believe that being friendly with the employees helps them open up, thereby making it easier for HR to handle employee grievance. Also, employees feel more comfortable and free to discuss their work-related concerns.
Richard Lobo
HR should closely work with business, design people practices and also champion the cause of employees. HR has to remain part of the larger goals and requirements of businesses. HR in isolation is useless—a mere admin function.
During performance management, in the presence of a friendly HR, employees are better prepared to take work-related feedback more positively. Such constant feedback provides them a sense of direction and boosts motivation.
HR is also a trusted partner to business teams. This means, they have to bring empathy, warmth and expertise into their association, which is seen as friendship. However, there is a need to maintain the professional boundaries even if an individual is likely to be inclined towards friends.
"HR has a role to play, which at no point can be compromised. So the line needs to be drawn when a friendship at work leads to a compromise in the core ethos/sanctity of the HR role," says Geethaa Ghaneckar CHRO, Raheja Universal.
While HR can and should develop friendships with an aim to increase productivity and corporate belongingness, drawing the limits can be slightly tricky.
Geethaa Ghaneckar
HR has a role to play, which at no point can be compromised. So the line needs to be drawn when a friendship at work leads to a compromise in the core ethos/sanctity of the HR role.
HR also acts as a moral custodian of human values. There can be checks and balances in the system, where seniors can step in to counsel and train employees on their behaviour and how not to be perceived as too casual.
"It is important to guide young talent in the HR team and groom them on this critical aspect of HR. Just as we know our limits with friends, similarly, we need to draw a line with our colleagues at work, and be well aware of what information to share and what not," said Rachan K, associate director-HR, Markelytics Solutions.
Anil Misra
HR carries out a critical function of maintaining confidentiality of information. Breaching that line by leaking salary or increment-related data is a fundamental violation of its code of conduct. Such behaviour is deemed irresponsible and attracts zero tolerance. Appropriate action is required in such cases, which can also lead to termination of employees in extreme cases.
There is a strict conduct pertaining to behaviour of HR professionals, wherein employees cannot toe the line. In an office setup, politics can't be ignored, but HR professionals are expected to demonstrate the maturity required to create a distinction between their personal and professional lives. The personal relationship with colleagues at the workplace and the values as an HR professional should not clash at any time, believe HR leaders.
"HR carries out a critical function of maintaining confidentiality of information. Breaching that line by leaking salary or increment-related data is a fundamental violation of its code of conduct. Such behaviour is deemed irresponsible and attracts zero tolerance. Appropriate action is required in such cases, which can also lead to termination of employees in extreme cases," says Anil Kumar Misra, CHRO, Magicbricks.com.
Some believe it is all about managing the boundaries in one's own mind; that it all depends upon how an HR professional implements the practices, policies and experiences without being partial, and while staying true to work.
Normally, business experiences a love–hate relationship with HR. It is never a loved department in any industry. But can it be trusted? Yes, it can certainly be.
seventeen − twelve =
Friends of HR
Previous articleHaryana Government amends labour laws in the interest of workers
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Sonali has left her mark as a journalist covering an array of beats across sectors in the popular pink dailies. These days, she is known as a communicator and a content strategist of sound repute. With seven years of journalism experience behind her, this lover of narratives and tales understands the business of human resources and the changing dynamics of the sector too well for us to not have her on our team.
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APT41 Serves Up State Hacking with a Side of Personal Gain
|In Threat Report
|By Threat Team
Researchers from FireEye have released a detailed report into a Chinese state-sponsored cyber espionage group they have named APT41. Over a period of seven years, the APT41 group has conducted cyber espionage activities against organizations in 14 countries, including the United States, the UK, France, Switzerland, South Korea, South Africa, Turkey, India, Italy and Japan. Targeted organizations belong to various industries including healthcare, media, pharmaceuticals, telecoms, travel, education and retail. Some of those compromises were timed in order to obtain intelligence related to corporate events, such as mergers.
What differentiates APT41 from other state-sponsored groups is that it has also targeted organizations related to the video game industry, in what appears to be financially motivated attacks, for personal rather than state gain. These attacks have occurred since 2014 and have occurred concurrently with the cyber espionage attacks. However, APT41 has used tactics, techniques and procedures developed as part of its video game industry attacks to improve the success rate of its cyber espionage attacks.
The APT41 group often utilizes stolen digital certificates to allows it to sign malware, making it much more likely to appear to be benign. Legitimately signed malware is also a key component of one of APT41's preferred attack vectors, targeted supply chain compromises. In June 2018, a supply chain compromise identified specific targets to receive malicious payloads based upon MAC address or hard drive serial numbers.
Researchers found APT41 utilizes over 46 different types of malware in its campaigns, including rootkits and master boot record bootkits (when particularly stealthy methods are required for specific targets). The APT41 group has remained persistent and able to adjust to reacquire a foothold into organizations within hours or days of actions taken by security teams to remove its malware. As an example, in a year-long campaign, APT41 utilized almost 150 unique pieces of malware, including backdoors, keyloggers, rootkits and information stealers, resulting in the compromise of hundreds of systems.
The malware deployed by APT41 can use genuine websites for command and control (C2) traffic, sites such as Microsoft Technet, Pastebin and Github.
How Does It Propagate?
APT41 uses spear phishing and supply chain compromises as common initial infection vectors. They are not known to use self-propagating malware, which would be considered too noisy for their purposes.
When/How Did BluVector Detect It?
All of the 14 publicly available samples were detected by BluVector's patented Machine Learning Engine (MLE). Regression testing has shown the samples would have been detected an average of 20 months prior to their release.
APT APT41 education healthcare media pharmaceuticals retail telecoms threat report travel video games
Threat Team
BluVector's Threat Report is written by BluVector's expert security team, tasked with identifying the latest cybersecurity threats in the wild and when our solution would protect customers from those threats. Get the latest Threat Reports here.
Filecoder.C Ransomware Attacks Android Devices
BRATA RAT Targets Brazilian Android Users


text:
Search in titles only Search in The Briefing Room only
All New Name That Aircraft - July 2009
brianw999
Nope, not a Beech 18. Here's some more...
If it 'ain't broken........ Don't try to mend it !
jkstark
Not a Grumman, is it?
You're right.....it's not a Grumman.
A hybrid developed from two types made by the same manufacturer.
B52STRATO
This is one true head crusher ! I'm near to bang mine against the comp'.
I first thought about some mixture from Northrop Alpha, Lockheed Orion/Explorer or Vultee V-1 on an experimental hull, but nothing appears as this one .
The pilot was left to freeze in an open cockpit. The passengers weren't !
OK - next shot in the dark... Consolidated comes to mind...
No, not Consolidated. The manufacturer from whose two types this aircraft was developed has already been mentioned here ! Named after a bird which would have been found in this aircraft's specific area of operations.
Here's some more of it....
guamainiac
Perhaps single engine .. er .. an early Lake prototype. Just kidding but this is tough.
Live, from a grassy knoll somewhere near you.
Purposely built for cold weather operations to keep the passengers comfortable. The passengers sat on either side of the aircraft in separate cabins. The pilot, on the other hand, was in an open cockpit !
Last edited by brianw999; 2014-11-12, 09:53.
Duck who flies up side down has a quack up? Grumman?
The Coast Guard on Guam had a head hunting party for me. After they wounded their old Grumman on the reef it came back with hull gashes. I made up a stencil in the WWII "nose art" genre and it was a duck with a crown and a broken neck with the slogan rocker "KING OF THE REEF".
Silly Coasties have no sense of humor when it came to the Navy
No, not a Grumman. It's a prototype/one-off built from parts of two different models from the same manufacturer....but not built BY the original manufacturer.
Here's the whole thing....
Petertenthije
Damn that's ugly. Also, it's a Rocheville Arctic Tern.
Please visit my website! http://www.schipholspotter.com/
Don't make me use uppercase...
Originally posted by Petertenthije View Post
That's the one. Over to you.
The message you have entered is too short. Please lengthen your message to at least 1 characters.


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The Storm at the Door
Stefan Block
Based on the true story of Stefan Merrill Block's grandparents' marriage, this is a heartbreaking and beautiful novel.
ebook paperback
AmazonGlassboxx
Just outside Boston, in 1963, Frederick Merrill found himself a patient in the country's premiere mental hospital, a world of structured authority and absolute control – a forced regression to a simpler time even as the pace of the outside world accelerated into modernity.
Meanwhile, in a wintry New Hampshire village hours to the north, Frederick's wife Katharine struggled to hold together her fracturing family and to heal from the wounds of her husband's affliction. Nearly fifty years later, a writer in his twenties attempts to comprehend his grandparents' story from that turbulent time, a moment in his family's history that continues to cast a long shadow over his own young life.
Spanning generations and genres, The Storm at the Door blends memory and imagination, historical fact and compulsive storytelling, to offer a meditation on how our love for one another and the stories we tell ourselves allow us to endure. Quietly incisive and unflinchingly honest, The Storm at the Door juxtaposes the visceral physical world of Frederick's asylum with an exploration of how the subtlest damages can for ever alter a family's fate.
StefanBlock
Stefan Merrill Block was born in 1982 and grew up in Plano, Texas. He graduated from Washington University in St. Louis in 2004. Block's first novel, the internationally acclaimed The Story of Forgetting, was published in 2008.
More books by Stefan Block
The Story of Forgetting, by Stefan Merrill Block, is a heart-breaking and inspiring debut novel.
The Story of Forgetting
An unforgettable romance that will set Summer 2022 ablaze.
You Made a Fool of Death With Your Beauty
Akwaeke Emezi
Of Mortal Love contains, for many critics and readers, the essence of all that is best in Gerhardie's writing, and Michael…
Of Mortal Love
William Gerhardie
This new novel from Glenn Patterson is a charming coming-of-age tale set in 70s Belfast
The Rest Just Follows
A mind-bending slice of pulp fiction, which takes a traditional noir story of detectives, toughs and femmes fatales and pushes it…
Alan Trotter


The Food and Drug Administration (FDA) approved a new formulation of Yonsa (abiraterone acetate) in combination with methylprednisolone as a treatment for men with metastatic castration-resistant prostate cancer (mCRPC), according to Sun Pharma, the company commercializing the treatment.
The approval was based on findings from a phase 2 study comparing the Yonsa formulation of Yonsa to the original, Zytiga, which was approved in 2011. In the trial, which was known as STAAR, Yonsa demonstrated therapeutic equivalence to Zytiga, based on serum testosterone levels, and both agents showed similar declines in PSA of 50 percent or higher (PSA-50).
"We are pleased to add Yonsa to our growing oncology portfolio and continue to deliver on Sun Pharma's commitment for enhanced patient access to innovative cancer therapies," Abhay Gandhi, CEO - North America, Sun Pharma, said in a statement announcing the approval.
The Yonsa formulation of Yonsa is developed to have a smaller overall particle size. In prior studies, the fine particle size was found to increase dissolution rates and oral bioavailability while decreasing the effects of food on treatment efficacy. In the phase 2 study, the 500-mg dose of Yonsa had similar absorption as the 1000-mg dose of Zytiga.
The STAAR trial included 53 patients with mCRPC who had not received prior Yonsa, enzalutamide, radium-223, or chemotherapy (unless it was docetaxel one or more year prior to study entry). Patients were randomized in a 1 to 1 ratio to receive Yonsa at 500 mg (four tablets at 125 mg each) or Zytiga at 1000 mg (four tablets at 250 mg each). Yonsa was administered with methylprednisolone at 4 mg and Zytiga was given with prednisone at 5 mg.
Across both arms, approximately half of patients (54.7 percent) had Gleason higher than 7 disease. There were more Caucasians in the Yonsa arm (83.3 percent) than in the Zytiga group (69 percent). The mean time since diagnosis of mCRPC was 2.1 years in both groups and baseline testosterone levels were 7.28 in the Yonsa group and 7.95 in the Zytiga arm (8.4 percent relative difference).
The mean testosterone level at day 9 and 10 was 0.32 (±0.45) in the Yonsa group and 0.29 (±0.29) in the Zytiga arm. The median level at day 9 and 10 was 0.15 with Yonsa and 0.19 with Zytiga. At day 28, patients in both arms had a mean testosterone level of 0.10 and the mean was 0.22 (±0.26) and 0.25 (±0.30) in the Yonsa and Zytiga groups, respectively. At day 84, the median was 0.10 with Yonsa and 0.15 with Zytiga.
PSA-50 was observed in more than 65 percent of patients in both arms of the study. The least square mean difference in serum PSA level between Yonsa and Zytiga at day 28 was -15.13. At day 84, the difference was -18.80.
Overall, fewer patients experienced treatment-emergent adverse events (AEs) in the Yonsa arm compared with Zytiga (75 percent vs 82.8 percent, respectively). Grade 3 or higher AEs were experienced by 16.7 percent of patients in the Yonsa arm and for 17.2 percent in the Zytiga group. Four patients had a serious AE in the Yonsa group compared with 7 in the Zytiga arm, two of which led to death (prostate cancer progression and myocardial infarction).
Yonsa (Zytiga) was initially approved as a treatment for men with mCRPC following chemotherapy. It subsequently gained approval for use prior to chemotherapy. In February 2018, Zytiga was approved in combination with prednisone for patients with metastatic high-risk castration-sensitive prostate cancer.


Saturday morning was a wonderful time for Little Known Help Zone at WSE's color-a-thon after party.
This event was bustling and busy, with tattoos and manicures that were quite a hit. Also, some more crayons and bracelets were sold! The success raised $55 more for the causes, and right now we are at 201/860 with the goal! Getting there.
Check our some pictures from the event below.
For Little Known Help Zone's next fundraiser, there will be a stand at Western Salisbury's PTA Color Run After Party.
At the stand, crayons, bracelets, and paperclip bookmarks will be sold. Information will be shared about Little Known Help Zone and its goals, and there will also be some fun activities! There will be nail painting and tattoos for sale.
The crayons are for sale on Etsy, and Little Known Help Zone highly recommends you check them out!
The crayons are being sold in packs of 5, both with and without glitter. The packs are $10, and are such a steal!
All the money goes to send a child in Guatemala to school through the program run by Mayan Families. To send a child to school, $360 need to be raised. Buying a pack of crayons would help greatly with this fundraiser!
These crayons make perfect gifts, and everyone can enjoy them.
The work for Guatemala has been complete.
No crayon is the same, just like no child is the same.
As of now, 6 dozen crayons are available to buy, and Little Known Help Zone is requesting donations of broken or old crayons from locals in the community to work and make more crayons. The more sold, the more children sent to school!
The crayons will be spread out on the table so children can view all of them and choose.
After the event, these will be listed on easy for purchase.


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DC beat SunRisers Hyderabad in first Super-Over tie of IPL 2021
Updated by admin on Saturday, May 01, 2021 11:10 AM IST
Chennai: Delhi Capitals (DC) beat Sunrisers Hyderabad (SRH) in a Super-Over thriller in Match 20 of the IPL 2021 at the M. A. Chidambaram Stadium in Chennai on April 25.
Prithvi Shaw and Kane Williamson top-scored for their respective sides but the contest turned out to be a nail-biter with DC eventually emerging victorious in a close contest.
Chasing a target of 160, SRH openers – David Warner and Jonny Bairstow – got off to a watchful start, scoring 10 in the first two overs. However, SRH lost their skipper after he was run-out at the striker's end in the fourth over.
Bairstow continued to take on the DC spinners. Williamson was up and away with two fours as well. With Bairstow's exit, SRH ended the powerplay with a total of 56/2.
The pressure was building on SRH as they required 43 off the final four overs and Axar struck twice in consecutive deliveries. Both – Abhishek Sharma and Rashid Khan – were trapped in front in the 17th over.
Vijay Shankar and the well-settled Williamson added 11 runs off Mishra's over, with SRH requiring 28 runs off the final two.
Avesh Khan bowled the penultimate over and castled Shankar's stumps but J Suchith smashed a six and four off the final two balls of the over.
With 16 runs required off the final over, Suchith came to the rescue for SRH and hit Rabada for a four and a six in a thrilling finish to the game. With 2 required off the final delivery, the match was tied and went to a Super Over.
DC went ahead with Axar Patel in the Super Over against Warner and Williamson. SRH only hit one four and set a target of 8 runs after a short-run from Warner on the last delivery.
SRH chose Rashid Khan to defend 8 runs against Dhawan and Pant. The DC skipper reverse swept Rashid for a crucial four on the third delivery. With one run required off the final ball, DC squeezed in a tight run and beat SRH in the Super Over.
Topics: Hyderabad News, Telangana News, Indian Sports, Cricket News, Ipl 2021, Delhi Capitals, Sunrisers Hyderabad, T20 News,


The newest member of the Reid Park Zoo family is a male tamandua born on Aug. 31. Tamanduas are lesser-anteaters that are much smaller than giant anteaters and can live in trees.
Watch the Tucson 12 video below to see a quick health check of the baby when he was 10 days old.


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Species Directory
Blackchin Guitarfish
Overview Conservation & Management Resources
Rhinobatos cemiculus
ESA Threatened - Foreign
Throughout Its Range
Up to 57 pounds
Up to 8 feet
Commercial fishing, Subsistence fishing
See Regulatory Actions
The blackchin guitarfish is a cartilaginous fish, similar to a ray or skate. The species once occurred in shallow waters throughout the Mediterranean Sea and eastern Atlantic Ocean, from Portugal to Angola. It no longer occurs in many areas of the Mediterranean, and it is rare in West Africa. The main threats to the blackchin guitarfish are commercial fishing to supply the shark fin trade and subsistence fishing to supply meat to growing coastal populations. In 2017, NOAA Fisheries listed the species as threatened under the Endangered Species Act. The common guitarfish and Brazilian guitarfish are also listed under the Endangered Species Act. Read more about the blackchin guitarfish.
"Blackchin" refers to the dark spot on the snout and is especially noticeable in juveniles. The blackchin guitarfish is brown on top and white underneath. It has small thorns throughout its body
Behavior and Diet
The blackchin guitarfish eats invertebrates, such as shrimp and other crustaceans.
Where They Live
The blackchin guitarfish lives in shallow, sandy and muddy bottom habitats. It occurs in the Atlantic Ocean, from northern Portugal to Angola. In the Mediterranean Sea, it occurs primarily along the North African shore (in the waters of Morocco, Tunisia, Egypt, and Libya) and the Eastern basin, from Turkey to Israel. The species is no longer found in the waters of Spain, Italy, and the Aegean Sea.
Lifespan & Reproduction
Female blackchin guitarfish give birth to live young in the shallow waters of West Africa during August and September.
Commercial and subsistence fishing
The blackchin guitarfish is targeted for its fins to meet the high demand for shark fins in eastern and southeastern Asia. It is also targeted for its meat by coastal populations in several countries.
Rajiformes
Rhinobatidae
Rhinobatos
cemiculus
In 2013, NOAA Fisheries received a petition (PDF, 538 pages) to list the blackchin guitarfish as threatened or endangered under the Endangered Species Act. In our 90-day finding, we concluded that the petitioned action may be warranted. After completing a Status Review, we proposed to list the species as threatened and requested comments from the public. In 2017, NOAA Fisheries listed the blackchin guitarfish as threatened under the Endangered Species Act.
Key Actions and Documents
Actions & Documents Incidental Take
Listing Foreign Species Under the ESA
Status Review Report of Two Species of Guitarfish : Rhinobatos Rhinobatos and Rhinobatos Cemiculus


text:
Phase 1 Clinical Trial Begins for Malaria Vaccine Candidate Based on iBio's Proprietary Technology
by Jennifer Levin |
NEWARK, DE--(Marketwired - Feb 10, 2014) - iBio, Inc. (NYSE MKT: IBIO), a leader in plant-based biotechnology for developing and manufacturing biological products, reported the initiation of a Phase 1 human safety and immunogenicity clinical study of a transmission-blocking malaria vaccine candidate. The vaccine candidate was produced on the company's proprietary iBioLaunch™ platform by the Fraunhofer USA Center for Molecular Biotechnology.
The text describing the program, released by the Fraunhofer USA Center for Molecular Biotechnology, follows:
'Fraunhofer USA Center for Molecular Biotechnology (FhCMB) announced today that clearance was obtained from the U.S. Food and Drug Administration (FDA) for an investigational new drug (IND), Fraunhofer's plant-derived malaria transmission-blocking vaccine (TBV), which targets the Pfs25 antigen, to proceed into the clinic in a Phase 1 safety and immunogenicity study.
Antibodies directed at Pfs25 can block transmission of the malaria parasite from mosquitoes to humans by preventing the parasite from developing in the mosquito. In preclinical models, purified plant-derived virus-like particles containing Pfs25, in combination with the adjuvant Alhydrogel®, have been shown to induce antibodies that effectively block infection of mosquitoes that have fed on an infectious blood meal. If these results can be reproduced in humans, the vaccine approach may provide a strategy to interrupt malaria transmission and thereby contribute to reduction of the P. falciparum disease burden.
"Entering this clinical trial is an important milestone," said Dr. Yusibov, Executive Director of FhCMB. "We have moved targets from molecular engineering all the way through to pilot scale manufacturing in plants under good manufacturing practices and evaluation in a Phase 1 clinical trial."
Development of this malaria TBV is an effort to improve global health by supporting the development of critical platform technologies for delivering vaccines to malaria-endemic countries. As part of the planned collaboration strategy, FhCMB, the PATH Malaria Vaccine Initiative (MVI) and Accelovance entered into an agreement to conduct a Phase 1 clinical trial.
"We are excited to see this promising new vaccine approach advance to clinical testing," says Ashley J. Birkett, PhD, Director of MVI. "Vaccines that can induce immunity to break the cycle malaria parasite transmission between humans and mosquitoes have the potential important interventions to accelerate future elimination and eradication efforts."
This Phase 1 clinical trial was initiated in early November and is being conducted by Accelovance.'
This clinical trial is the third human study of vaccine candidates produced on the iBioLaunch platform under license from iBio. The completion of two Phase 1 clinical trials of influenza vaccine candidates, one for H1N1 influenza and one for H5N1 influenza, have previously been announced. iBio owns the technology used in this program, and has the right of reference and the right to use and incorporate information from this clinical trial in additional applications for regulatory approval of products or processes and for the manufacture and commercialization of products.
About iBio, Inc.
iBio develops and offers proprietary products and product licenses, based on its proprietary iBioLaunch and iBioModulator™ platforms, providing collaborators full support for turn-key implementation of its technology for protein therapeutics and vaccines. In Brazil, iBio has been collaborating with Oswaldo Cruz Foundation (Fiocruz) and Fraunhofer Center for Molecular Biotechnology since 2011 to develop a recombinant yellow fever vaccine based upon iBio technology.
The iBioLaunch platform is a proprietary, transformative technology for development and production of biologics using transient gene expression in unmodified green plants. The iBioModulator platform is complementary to the iBioLaunch platform and designed to significantly improve vaccine products with both higher potency and greater duration of effect. The iBioModulator platform can be used with any recombinant expression technology for vaccine development and production. Further information is available at: www.ibioinc.com.
STATEMENTS INCLUDED IN THIS NEWS RELEASE RELATED TO IBIO, INC. MAY CONSTITUTE FORWARD-LOOKING STATEMENTS WITHIN THE MEANING OF THE PRIVATE SECURITIES LITIGATION REFORM ACT OF 1995. SUCH STATEMENTS INVOLVE A NUMBER OF RISKS AND UNCERTAINTIES SUCH AS COMPETITIVE FACTORS, TECHNOLOGICAL DEVELOPMENT, MARKET DEMAND, AND THE COMPANY'S ABILITY TO OBTAIN NEW CONTRACTS AND ACCURATELY ESTIMATE NET REVENUES DUE TO VARIABILITY IN SIZE, SCOPE AND DURATION OF PROJECTS. FURTHER INFORMATION ON POTENTIAL RISK FACTORS THAT COULD AFFECT THE COMPANY'S FINANCIAL RESULTS CAN BE FOUND IN THE COMPANY'S REPORTS FILED WITH THE SECURITIES AND EXCHANGE COMMISSION.
Ron Both
Liolios Group, Inc.
Jennifer Levin


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Anyone sending forms to IRS or US Treasury needs to keep in mind the time frames to avoid penalties and possible covered expat status. I did the forms myself as my financial situation was relatively simple. Then mailed everything by Canada Post with tracking and delivery signatures required. All related paperwork needs to be kept in one's files, maybe forever.
We are among the fortunate ones to find closure and be able to say goodbye to a toxic relationship with the IRS.
Just received instructions for an appointment in Canada to renounce. They no longer require the redundant and confusing DS-4079.
In the case of two US citizens married, gobsmacked to discover they are both US taxpayers after decades of living overseas, (bloody unlucky!), where both want to renounce and exit cleanly, is there any reason to file married versus single? Not looking for tax refunds, not expecting to owe tax, just looking to get out as simply as possible.
Given that both are US citizens, filing as Married Filing Jointly (MFJ) would mean one return for each filing year instead of two, could save tax preparer's fees (if you use one), reduce the quantity of forms to file, may avoid form 8938, and potentially give a bigger safety margin for zero tax. As a US citizen married to an alien, I changed to MFJ, because in the year I received retirement/severance pay it made the US1040 bottom line equal zero, whereas filing a return for myself alone would have created US tax owing.
I came across information about "Selective Service Registration: Renunciation of Citizenship by Dual Nationals" on the US Embassy, Bahamas, website, which appears to have been added yesterday. Thought I'd post, because although the this topic is mentioned in the Statement of Understanding of Consequences (DS-4081, point 7), I don't recall running into much (any?) actual information about Selective Service and Renunciation prior to this on the consulates' sites.
"(a) Question: Is the person who renounces citizenship for the express reason of avoiding the Selective Service registration requirement likely to encounter any added difficulties or legal problems if he should later decide to visit the U.S.?
Answer: Apart from having to qualify for the class of visa which he is seeking, such an individual will experience no difficulties or legal problems should he seek to enter the U.S. However, should he enter the U.S. as an immigrant, or should he adjust status while in the U.S. to that of a permanent resident or should he lose his non-immigrant status and remain in the U.S. he would be obliged to register with the Selective Service system within thirty days of entry or change in status. Such liability would remain until he attains his 27th birthday.
(b) Question: Does renunciation of citizenship after the date the person was scheduled to register obviate the requirement to register?
Answer: No. A U.S. citizen who is required to register under the law will be required to register or be subject to the penalties of the law. However, the Dept cannot assess at this time whether a prosecution would be taken in any individual case, as this is a matter which falls within the jurisdiction of the Dept of Justice.
(c) Question: What is a person's status with regard to Selective Service if he renounces after having registered?
(d) Question: Is there any need for the ex-citizen to notify Selective Service of his renunciation of citizenship?
Answer: Yes. Selective Service has stated that it will remove the names of renunciants, who are resident outside the U.S., from their rolls. Since such a person would be an alien resident outside of the U.S., he would not be subject to the provisions of the Military Selective Service Act (MSSA) and therefore not actually subject to a call up. SSS cannot know about a change in the registrants status unless he advises them promptly and sends a copy of his Certificate of Loss of Nationality to them as evidence of his alienage.
fn0, thank you for your thoughts. Also wondering if it is better or worse from an audit perspective for two married people to file joint versus separately.
@Malice, it would depend on what you're trying to protect against. MFS would shield separately owned assets of one spouse from being used to pay the tax liability of the other. MFJ mingles all the income together and might make it more difficult to figure out from the return who owns what. "Better" will depend on facts and circumstances. If real money is involved, might be best to consult a lawyer (not an accountant).
Re: Also wondering if it is better or worse from an audit perspective for two married people to file joint versus separately.
The tax software I have used has always told me that with zero tax owing, my risk of being audited is very low, both when I filed singly and jointly. Can't guarantee the software is right, but I didn't think it worthwhile to pay for an expert opinion on audit risk. My earned income was always less than the Foreign Earned Income exclusion (FEIE) except in the year I retired, and passive income was low, The US taxes on earnings and passive income were cancelled by the combined effect of the FIEI and Foreign Tax Credits (FTC). These thoughts are not advice and I don't know whether or how FEIE and FTC can all be claimed when the filings are for back years – you will likely need an expert to help you with the filings.
Report on renunciation experience earlier today (2016-09-07) in Vancouver BC.
I had requested the instructions and forms by email in February and received them almost immediately. It took some time to complete the forms, and to assemble and scan the requested documents. On 2 June 2016 I emailed completed questionnaire and forms DS-4079, 4080, 4081, with scans of a US passport, US passport card, US naturalization certificate, and Canadian passport. An email response on 28 June 2016 scheduled a Loss of Nationality (LON) appointment for 7 September 2016 at 14:00.
Arrived for appointment about 13:45, cleared initial security outside side door of building. I already knew not to have a car key fob, USB, cellphone or anything else with electronics in it like a smart-watch. I was warned there were no washrooms on the 20th floor, and escorted to the elevator, which took me and another customer up to the 20th floor. There another security check airport-style (belt removal, empty pockets, scanning of tray of belongings, walk through detector, manual check of eyeglasses, watch and tie, and checking I had no sealed envelopes). The checks were thorough, quick, professional and more polite than the TSA would have been. Through security at 13:55 I was directed towards a heavy glass windowed counter. A helpful assistant was ready and took my US passport, US passport card, naturalization certificate, Canadian citizenship certificate, Canadian passport, pre-purchased ExpressPost envelope with my name and address in the "To:" field, and Nexus card. The Canadian citizenship certificate was returned right away. It was stated that the US passport would be returned cancelled when the COLN is sent out, and I would get the Canadian passport back from the officer who would take my oath. If the Nexus card had said US citizen on it it would have been retained but as it said Canadian citizen so I got to keep it (for duals, the citizenship shown on the Nexus card depends on where you reside when you apply). We moved to a payment window and I paid $2350 on my credit card. The "from" field on the ExpressPost envelope was stamped with the address of the American Citizen Services Unit in Vancouver, and I was given the counterfoil to keep as it had a reference number on it. After payment, I was given papers to read about the implications of renunciation and sent to a waiting room for US citizens. When the consular officer was ready I was called to another window to see him. He checked I had not changed my mind, and asked me why, how long had I been thinking about it, and did I understand the implications. I replied I was too old to change my mind, all my family was in Canada, and I had given up ties and property in the USA, had been thinking about it for two years or more, and understood renunciation was irrevocable. He administered the oath, had me sign the papers, and returned my Canadian passport. The officer was businesslike and quick. He said he would be recommending issuance of a COLN. Recent COLNs had been issued quite quickly since some functions had been centralized in Vancouver, but the official advice was 2 to 6 months.
Earlier the assistant had said to make copies of the COLN when received, keep one with my passport to show it only if questioned by US customs and immigration. Until the COLN comes, the receipt for the fee should serve (it says it's $2350 for a "CERT OF LOSS OF"). In all likelihood I would not be questioned when visiting the US because the country of birth on my passport is other than the USA.
Out of the door at 14:35. The whole process including security and waiting time was 50 minutes.
Not renouncing would not have been fair on the rest of my family In Canada, or myself for that matter. I feel very sad about giving away something I had wanted and worked hard to get, and at the same time very happy to be free of it. I guess like a divorce.
Thank you. 3 months and 5 days for Vancouver doesn't seem so bad.
3 months from request to appointment was less than I had expected based on other comments. I was happy to get one before year-end 2016 as it will mean no 2018 filing struggle for tax year 2017.
fn0 Would you kindly tell me if you were offered a range of dates for your appointment?
Was I given a range of dates? No – just the one. No confirmation requested.
19 year old daughter renounced in Calgary at the beginning of June, received her CLN at the beginning of September.
17 year old son requested at the beginning of July a loss of nationality appointment in Calgary for next year, when he will be 18. Had a reply today, at the beginning of September, with a late April date for his appointment.
We are getting there, slowly and surely!
Someone asked me for help in renouncing US citizenship, and is trying to figure out if s/he can afford the exit tax.
This person is past retirement age, and of course the biggest issue is the foreign pension earned after s/he left the US. S/he has already made the decision to not take a lump sum payout, but rather convert it to an annuity in his/her country of residence. IRS Publication 939 can be used to calculate the expected value of the pension, and with some effort, s/he might be able to calculate the sum total of contributions over her/hes working lifetime. Since these contributions have already been us taxed, it would seem that the General Rule documented in IRS Publication 939 applicable to even non-qualified pension plans would also qualify in reducing the exit tax s/he would have to pay on the pension amount, just as the cost basis of the various deemed capital-gains is used to reduce the amount of the tax on the assets at renunciation time.
My question is, is it acceptable to use the General Rule like this? The examples posted on citizenshipsolutions.ca don't, and they're shocking. If it were acceptable to do this, which seems morally right as well as consistent with the regulations, that would lessen the exit tax bite considerably.
The better way is to only include assets that total under 2 million or better still don't file anything.
Congrats, it's wonderful that your daughter got her CLN so quickly and your son now has an appointment lined up! That's fantastic news!
Glad everything went well for your daughter in Calgary and she has her CLN in hand, Rebecca. Only one more child to go before your family is free? Good luck to your now 17 year old son — he'll know what to anticipate with those in his family that have gone before him.
Thanks for your report, Rebecca, and congratulations on your family's progress.
Are you going into Streamlined?
This suggests the pension isn't a pension at all from the US perspective, but was treated for US tax as if it is just a 'normal' investment account. If that is the case, and if annual US tax was paid on dividends accrued in the account, then you can work out the contributions, find the capital gain, and shelter it using the $690k or so exit tax allowance. A huge problem with pensions that you treat as pass-through for US tax, though, is the high probability that PFIC rules apply to the funds held in them.
Bottom line is that if these are not US qualified pensions (likely), not covered by or elected into any treaty (possible), and both contributions and income have been fully and properly reported for US tax annually (very tricky, and perhaps unlikely, but technically possible, and can perhaps be fixed if necessary by amending earlier returns), then they won't fall under the exit tax rules for pensions and deferred income.
But you really need professional help with this. It is a minefield, and an expensive one at that. I don't think anybody here is going to be qualified to answer your questions, even if you handed out every last detail (which you probably shouldn't).
Actually @Watcher, I think you're misinformed, and you didn't read my question. The one thing treated differently for form 8854 is deferred compensation items. Further, even had s/he been able to find out the return on his/her pension funds (which is not at all evident with many foreign pension funds), since the funds have already been annuitized, any paper return shown along the way would be very unlikely to correspond to the value of the deferred compensation item as far as US taxes are concerned. Pub 939 has all sorts of actuarial tables for that, which start from the amount the recipient receives yearly in a pension, his/her age, whether it's a surviving spouse pension, and other things.
So the only things known are the contributions, which have already been taxed.
This person came to me apparently after having gone to a couple of professionals with 'impressive' hourly charge rates, who nonetheless didn't seem to be too much on the ball. They recommended the most punitive path possible. I am known for simplifying rather than complicating things, and my ability to digest information put in front of me, so I got called into the picture.
I remember when I first moved abroad nearly 20 years ago, I asked H&R block whether I needed to file a US state tax return, if the only income I had from that state was interest on a bank account. Rather than tell me: "No, interest is considered to be sourced where you live," the agent started into this complicated process to prove that I was still a resident of that state, asking me whether I went to the dentist there, or church, or doctor. All answers were 'no,' but she still kept on going with her inquisition. I finally had to turn her in to her boss to get her to stop.
Publication 939 on the general rule is 83 pages. Publication 575 the simplified rule is 42 pages. I imagine no one knows how to get it right for a foreign plan. A long time ago a wise man said on this site-'only tell them they already know'. Just do it whatever way works best.
@CEB – "I think you're misinformed … The one thing treated differently for form 8854 is deferred compensation items.
I am more than well aware of the distinction for retirement savings. It is this singular aspect of the US exit tax, and pretty much this one alone, that motivated me to leave the US when I did.
That said, I clearly have not understood the type of pension you refer to here. Mine were all tax-deferred defined contribution schemes, and so relatively easy to value and map down onto US tax laws. The one you are dealing with here sounds like something entirely different, and I am not going to attempt to pick it apart.
My one last suggestion, though, would be to check any tax treaty for possible help. The exit tax is appalling when it comes to pensions and retirement savings, but the fact that it conflicts with several tax treaties might provide an escape route if all else fails.
@Watcher. I explained the difference between a deferred compensation item and other items that get treated on an 8854 in response to your suggestion that the $690K exclusion be applied to a deferred compensation item. As far as I know, this is not possible.
I was also not asking you to 'pick [this person's retirement plan] apart.' Rather, my question was simply whether one could exclude previously taxed contributions to non-US retirement plan savings in the calculation of the exit tax, the same way one excludes them when listing pension income on the tax return using the General Rule. Since the same form is used to compute the exit tax, I would imagine this would be the case.
The US exit tax, odious as it may seem, was designed to capture taxes on non-realized capital gains that might otherwise escape due to expatriation. It does not seem to be designed to simply be a wealth tax — for example, for non-deferred items, it's possible to exclude the cost basis of the item in question in computing the capital gains tax. For cash positions, which have already been taxed throughout the years the person was a US citizen, the cost basis will be the value of the cash position, leaving as a capital gain only the (epsilonic) bank interest on accrues on such accounts.
So it would seem reasonable to do the same thing for deferred compensation items. Portions previously taxed should not be taxed again. I was simply asking if others had already followed this approach.
The examples I've seen suggest not, but then again, this is a brand new tax (or it's application is new, because people have been driven to expatriate). So I'm curious about why this hasn't been included in the published examples (cf. John Richardson's site).


Dates and times: See website for the latest opening days and times of the different areas of the estate.
Hire information: The study base can be hired for small private functions. Meadley's Meadow, behind the Visitor Centre, can also be hired out.


text:
Day 4 Amakusa & Kumamoto
Nagasaki Pilgrimage 6 days tour
Amakusa, is located in a southern part of Kumamoto-city, and consists of Shimo-jima,
Kami-jima and many other islands varied in size, which belong to Unzen-Amakusa
National Park along with Unzen.
Amakusa has the Christinan Pilgrimage sites where Christian faith
continued even during the ban on Christianity, Sakitsu Village has been registered on
UNESCO World Heritage / Hidden Christian Sites.
8:00 Depart Hotel
Visiting Hidden Christian sites in Amakusa
Oe Cathedral
Sakitsu Village
Amakusa Shiro Memorial Hall
Travel Amakusa Gokyo / Pearl line
Transfer to Kumamoto
Exploring Kumamoto
Sakurano-baba Josaien
Kumamoto Castle
Stay in Kumamoto
The oldest Catholic Church in Amakusa and was one of the first churches built right after the ban
on Christianity was lifted. The Romanesque-style architecture and the chalky white structure was
rebuilt in 1933 by a French missionary priest named Father Garnier using his own money and
contributions from local Christians living in the area.
Sakitsu Village / UNESCO World Heritage
A Gothic-looking church is located on a cove of a fishing village. In 1934, a French priest Augustin
Halbout MEP purchased the premises of the former village headman and built a wooden and
concrete finished church, with Tetsukawa Yosuke's design and construction. He placed the altar
at the very site where fumie or a test to ensure non-allegiance to Christianity had been conducted.
The theme Museum shows History of Christianity in Amakusa and Shimabara Rebellion in
Harajo Castle Ruins which was a peasant uprising agaist bakufu's persecution of Christians
under the leadership of Amakusa Shiro in 1637.
Josaien is located in Sakurano-baba, at the foot of Kumamoto Castle, one of Japan's three
major castles. It is a popular tourist attraction designed to enhance the appeal of the old castle
town and convey to visitors the food, history and cultural traditions of the region from Kumamoto
Castle, a symbol of the Kumamoto-city.
The Castle is one of the three great castles and one of the 100 best places in Japan to view cherry
blossoms. Due to the Earthquakes in 2016, several of the castle's shacihoko ornaments were
destroyed, and a large number of kawara tiles also fell from the roof. Now the restoration activities
are being performed as fast as possible. Now, the Kumamoto Castle can be seen from the outside
of the moats surrounding the castle.
Amakusa
- Nagasaki Christian Pilgrimage tour