text:
All Hepatology
Autoimmune/Cholestatic/Biliary Diseases
Chronic Hepatitis
Cirrhosis/Liver Failure
Drug Metabolism/Pharmacology
Liver Injury/Regeneration
Steatohepatitis/Metabolic Liver Disease
GI Bookshelf
Hepatology Topics
Liver cancer recurrence rates similar regardless of DAA experience
Singal AG, et al. Gastroenterol. 2018;doi:10.1053/j.gastro.2019.01.027.
Patients with complete response to hepatocellular carcinoma and underwent direct-acting antiviral therapy for hepatitis C had similar rates of cancer recurrence compared with patients who did not receive DAA therapy, according to a study published in Gastroenterology.
"Our results suggest that use of DAA therapies is safe and potentially beneficial in hepatitis C-infected patients with a history of liver cancer," Amit G. Singal, MD, from the University of Texas Southwestern Medical Center and lead study author, said in a press release. "Based on these new data, providers can feel reassured that it is safe to treat hepatitis C in these patients and allow them to receive the known benefits of hepatitis C therapy."
Singal and colleagues analyzed data from 793 patients, 304 of whom underwent DAA therapy and 489 were untreated. Over a median follow-up of 10.4 months, the researchers observed 416 recurrences, including 128 in the DAA-treated patients and 288 in the untreated patients.
After adjusting for time-varying exposure, DAA therapy did not correlate with HCC recurrence in crude (HR = 0.79; 95% CI, 0.63-1) or adjusted (HR = 0.9; 95% CI, 0.7-1.16) or propensity score analyses (HR = 0.91; 95% CI, 0.69-1.19).
Additionally, the researchers confirmed that DAA therapy did not correlate with early HCC recurrence in crude (HR = 0.81; 95% CI, 0.6-1.1), adjusted (HR = 0.96; 95% CI, 0.7-1.34) or propensity score analyses (HR = 0.96; 95% CI, 0.67-1.38).
These results were consistent across all subgroup analyses including tumor burden and HCC treatment type.
"Our data are consistent with more recent studies, which have found most recurrences are detected at an early stage and can be treated with potentially curative treatments," Singal and colleagues wrote. "While it remains important to monitor patients for recurrence during and after DAA therapy, available data suggest HCC surveillance intervals and treatment decisions do not need to differ from DAA-naive patients." – by Talitha Bennett
Disclosure: Singal reports he was on the speakers bureau for Bayer, and Bristol-Meyers Squibb and Gilead; has served on advisory boards for AbbVie, Bayer, Eisai, Exact Sciences, Gilead, Roche and Wako Diagnostics; serves as a consultant to Bayer, Glycotest, Eisai and Roche; and has received research funding from AbbVie and Gilead. Please see the full study for the other authors' relevant financial disclosures.


text:
Q: Iron-signal alternate in Polymer 2? I have been using iron-signals almost everywhere in my application.
Now I was upgrading my polymer 1 application to polymer 2 and I found that <iron-signals> is not used anymore.
What is the alternate path to achieve the same. I basically want to pass data between different pages in my web app.

A: You should be able to simply dispatch events on window from one element and listen for them in other elements.
Example:
// Element 1

class FooElement extends Polymer.Element {
  connectedCallback() {
    super.connectedCallback()
  }

  ready() {
    super.ready()
    window.addEventListener('bar-was-called', e => {
      console.log(e.detail) // logs 'hello-bar'
    })
  }
}

// Element 2

class BarElement extends Polymer.Element {
  connectedCallback() {
    super.connectedCallback()
  }

  ready() {
    super.ready()
  }

  doBar() {
    window.dispatchEvent(new CustomEvent('bar-was-called', {
      detail: 'hello-bar'
    }))
  }
}

Side note
Keep in mind that iron-signals was removed for a reason. AFAIK it's that it promotes a hard-to-debug communications architecture.
From <iron-signals> README:

Note: avoid using iron-signals whenever you can use a controller (parent element) to mediate communication instead.

A: Iron Signals have been deprecated in polymer 1.
Replace uses of iron-signals with iron-meta.

redpajama_set_name: RedPajamaStackExchange


That means we are a Specialist!
Invisalign Teen works like braces but is CLEAR! No one will ever know you are wearing it.
How long will I want to hide my smile?
Not a single day! Invisalign Teen will allow you to go to dances, out with your friends, and meet new people all without worrying about your smile. As a matter of fact, you will be smiling bigger in no time!
Because you remove Invisalign Teen when you eat there are no worries about breaking anything so you can still eat everything!
What is Invisalign Teen really like?
Invisalign Teen – won't slow you down.
I play sports and a musical instrument. What about that?
Choosing Invisalign Teen is a great decision if you want the freedom of clear removable aligners.


Hi. If you are looking for the DNC part of this blog, I've put it on another page.
You can get to it here: http://librarian.net/dnc.
RSS feed is here http://librarian.net/dnc/index.xml.
Please update your links, thank you. I leave for Boston on Sunday morning.


This blog post was written by George Ratiu, Director of Quantitative & Commercial Research and Erin Fitzpatrick, Research Intern.
Real estate is an integral part of economic activity, with transactions providing avenues for exchange, development, and growth opportunities. Within this framework, like-kind exchanges (LKE) provide an important vehicle to sell and acquire property.
Like-kind exchanges are available to individuals, partnerships, corporations, limited liability companies, as well as trusts. The main requirement of a like-kind exchange is that the sale of one property and acquisition of another property must be part of an integrated transaction, rather than two individual transactions.
Like-kind exchanges (LKE) feature prominently in NAR members' real estate transactions, as well as their clients. As most REALTORS are small business owners, and as they represent a wide range of small businesses across the country, LKE transactions are important for Main Street.
The Like-Kind Exchanges: Real Estate Market Perspectives 2015 report details the potential impacts upon REALTORS® transactions due to the absence of the tax deferral provision of IRC Section 1031. Repeal of like-kind exchanges or tax-deferral provisions would have a significant ripple effect through real estate markets. A majority of NAR members—95 percent—indicated that they would expect a decrease in real estate values if IRC Section 1031 was repealed. Additionally, 94 percent expected a decrease in demand for core assets/business/service as a result of a potential repeal.
In addition, repeal of like-kind exchanges would impact debt financing of real estate transactions. According to 86 percent of members, there would be a decrease in new constructions loans. Purchase money loans would experience a decline, as well, based on 63 percent of responses. Moreover, 66 percent of NAR members indicated that real estate would experience large increases in leverage. In terms of refinance activity, the responses were somewhat more balanced, with 58 percent considering there would be an increase in activity and 42 percent projecting a decrease in activity. To access the Like-Kind Exchanges: Real Estate Market Perspectives 2015 report, visit http://www.realtor.org/reports/like-kind-exchange-survey.


text:
Venting My Grief
Yuan, Zhen 1 (779-831 CE)
Though as talented as Prime Minister Xie's favorite daughter 2,
You had resigned yourself to hardship
Since you married me when I was as poor as Lou Qian 3.
After seeing that I did not have any other clothing to change into,
You rummaged through all the trunks.
After I coaxed and pestered you to buy wine for me,
You pulled out your gold hairpin to exchange it for the wine.
You were content with eating wild vegetables and old bean leaves.
For firewood we relied on fallen branches of old pagoda trees.
Now my salary has greatly improved,
But all I can do is prepare some offerings to honor you 4.
Once we joked about what would happen after death.
I cannot believe this casual attitude about death would be tested so soon.
I have given away almost all your clothing.
But not your needlework, for I still treasure it even though I cannot bear to look at it.
Because I miss you, I even take extra care of your servants.
I burned some paper money 5 for you several times because I saw you in my dreams.
I know everyone resents poverty.
Especially for a poor couple, everything looks sad.
Every time I sit at ease,
I lament your unfortunate life and mine.
How long can one live?
You Deng 6 did not have any sons and gradually accepted his fate.
What use was it that Yue Pan 7 wrote a poem to mourn his late wife?
Even if we are buried in the same grave,
Will we be able to meet again?
It is even more difficult
To wonder if we could marry in another life.
The only way I can repay you for your brows knitted with worry all your life
Is to think about you all night, never closing my eyes.
1 Wei-zhi and Wei-ming were Zhen Yuan's other first names. He was a native of Lo-yang City. Yuan passed the Advanced Exam in 793 CE, and in 803 CE he was honored as one of the Great Scholars. Early in his political career, he was a censor in the emperor's court. Later, he was sent into exile because he offended the eunuchs. He subsequently allied himself with them and was promoted to a high rank. At the peak of his career, he held the position of prime minister for three months. Yuan also wrote a love story called "Ying-ying". Later, Shi-pu Wang wrote a great novel, The Romance of the Western Chamber, based on Yuan's story (The Romance of the Western Chamber, translated by S. I. Hsiung, New York: Columbia University Press, 1968). One may view the following segment of the movie "The Romance of the Western Chamber",
https://www.youtube.com/watch?v=L-23yUSR3zU&feature=related
, to glimpse how a Chinese movie director in the 1940's interpreted Yuan's story.
During Emperor Mu-zong's reign, court ladies frequently sang poems entitled "The Palace" written by Zhen Yuan. They called him Gifted Scholar Yuan. Later, Commander Jun Cui of Jing-nan District returned to the capital. He presented Zhen Yuan's poems to the emperor. The emperor was pleased. He immediately appointed Yuan as a senior secretary on the Board of Worship Service, and later as a member of the Royal Academy in charge of the emperor's personal affairs.
Zhen Yuan wrote a preface to his poetry book and sent it to Ju-yi Bai. It says, "Whenever I am filled with moral indignation; am compelled by duty; discuss success and failure with friends; lament elapsed youth; record beautiful landscapes, scenic spots, my satisfactions, frustrations, and thoughts about the vicissitudes of life; drink wine before flowers; miss my old friends; lie ill; or encounter anything unusual, I like to express my thoughts and feelings in poetic form. I have been in exile for five years since I was thirty-two. During my exile, I have no other means than poetry to release my energy. I am not a Taoist without any ambition and I have no other interest than poetry. Therefore, I have devoted myself to poetry. I mingled refined and coarse lines and wrote many poems, but I did not copy them neatly for others to read. Jing-jian Li, a native of He-dong (east of the Yellow River) District and Mayor of Jiang-ling City, loved my poems. He said my poems contain profound meanings. He wanted to read all of them. Consequently, I compiled my poems into book form. My poems are divided into several classes. If a poem contains a virtuous theme and is close to the ancient style, I classify it as ancient satire. If a poem contains profound meanings and belongs to the folk style, I classify it as folk satire. If a poem is close to the ancient style but limited to expressing my feelings, I classify it as ancient style. If a poem is limited to describing objects or landscapes, I classify it as new folk style. If a poem's sound and flow are smooth and its parallel constructions are proper, I classify it as a regulated verse. If a regulated verse contains passion and irony, I classify it as regulated satire. My wife died when I was young. I wrote many poems to honor her. These poems are entitled "Mourning My Late Wife". Some of my poems are related to education and culture. Modern women love to be dressed up according to the latest fashion. Their hair styles, varieties of clothing, and choices of matching colors are amazing. I wrote more than a hundred poems about the beauty of women. [¼ ] I have heard that a scholar should aim to establish virtue. If he cannot, he should aim to make contributions. If he cannot do that, he should aim to write useful thoughts. One desires a job. If one cannot find it, one desires money. If one cannot find money, one desires food. I am not a gifted sage, so my virtue is incomplete. My talent is doomed to be unrecognized, so I have not had an opportunity to make any contributions. My character lacks divine graces, so my writings fail to set examples for later generations. I have devoted myself to poetry for almost forty years like an idiot or a crazy man. [¼ ] Now I am exiled at Tong City. The city is imperiled by tigers, leopards, and snakes and plagued by diseases carried through toads, spiders, and mosquitoes. [¼ ] I have little chance to survive. If I have the luck to come out of here alive, we should visit the capital together and fulfill our mission to make contributions and write useful poetry. If things become worse, I might be desperate for food someday. Then my situation would be worse than yours. I stored my poetry in my chests. It should be viewed as a game like chess, but I value it more than eating my fill. Perhaps my poetry is not even as worthwhile as the game of chess. [¼ ]"
Zhen Yuan wrote to Wen-gong Ling-hu, "I have been in exile for more than ten years since I was demoted from my post as censor. I was free and at leisure, so I dedicated myself to poetry. Having accumulated my poems over a long period of time, their number exceeds a thousand. I have expressed my thoughts and feelings in these poems. They contain the flavor of ancient musicians. Some of my poems are expressive. However, my words are straightforward and my style is coarse. Because I worry my poems may offend some people, I dare not show them to others. Consequently, I write short poems only to entertain myself while drinking wine. In my opinion, my forms are simplistic and my words lack strength. If I fail to inject some attitude into my poems, they may easily be viewed as vulgar and common. In order to make my poems have a lingering appeal, I often try to contemplate how to express myself, revise the rhyming schemes, and examine my parallel constructions. However, I am unable to accomplish my goal by myself. [¼ ]"
Zhen Yuan wrote an epitaph for Fu Du's tomb. It begins with a brief history of Chinese poetry by saying, "After reading Fu Du's poems, I realize that his poetry epitomizes the ancient poetic talents. Chinese poetry originated from the poems written by the emperor and his court officials to communicate their thoughts in poetic form during Emperor Yao and Emperor Shun's reigns. During the Xia, Shang, and Zhou dynasties, poets had followed this poetry style for more than one thousand years. Then Confucius selected the three hundred and five best poems about education and culture, and compiled them into The Book of Poetry. After Confucius died, Chinese poetry languished for centuries. Most poets began to write poems to express their sorrow, but their style and quality were still close to those in The Book of Poetry. During the Qin and Han dynasties the government eliminated the office that collected people's poems. Even so, ballads, lyrics, folk songs, and seductive as well as satirical poems had developed over time. The poem "The Cypress Beam Pavilion" written Emperor Wu-di of the Han dynasty was in the form of seven characters to a line. Wu Su (140-60 BCE) and Ling Li (d. 74 BCE) mastered the poetic form with five characters to a line. Although these poets wrote different styles and mingled refined and popular tastes, their poems contained profound meanings. They wrote poems to express their feelings rather than seek fame or profit. After the Jian-an Period Chinese writers suffered the disaster of civil wars. Cao Cao (155-220) and his sons often composed poems while in the saddle. Consequently, their poems were grand and vigorous. With respect to cadence, tragedy, or parting sorrow, their poems even surpassed classical ones. During the Jin dynasty public morals still persisted. During the Liu-song and Qi dynasties the foundation of education deteriorated. People tended to dissemble, take it easy, serve their own interests, and live an unruffled life. The style of their essays was bold and carefree; their colors were refined and clear. These essays lacked meanings and strength because they were limited to describing natural feelings, spirit and beautiful scenery. The decadency lasted through the Liang and Chen dynasties. The short poems written during the Liang and Chen dynasties were exquisite in form, but frivolous in content. These poems would have been considered devoid of value by the poets of Liu-song and Qi dynasties. Since the beginning of the Tang dynasty, provincial education has progressed vigorously. Individuals with mastery of various styles emerged in succession. Quan-qi Shen (656-715) and Zhi-wen Song (656-713) mastered poetry study, refined rhyming schemes, and established the style of regulated verses. From then on this new style of poetry steadily improved. However, those who loved classical poems left out the contemporary poetry. Those who stressed the ornate style lacked substance. Those who imitated the style of the Liang and Qi dynasties paled in comparison with the poets of the Wei and Jin dynasties. Those who mastered the folk style were not good at the form with five characters to a line. Poets who lived a carefree life might lack some experiences needed for certain styles of poetry. A poem with a proper rhyming scheme may lack a framework. Fu Du's poems improved Chinese poetry dramatically. His ancient style approaches the level of The Book of Poetry. His contemporary style includes the merits of Quan-qi Shen and Zhi-wen Song's poems. Du's choice of words surpassed Wu Su and Ling Li's. Du's spirit swallows Cao Cao and Xie Liu's (465-522). Jan-zhi Yan and Ling-yun Xie's (385-433) pastoral poetry pales in comparison with Du's. Du's poems also include the beauty and fluency of Ling Xu (507-583) and Xin Yu's (513-581) poetry. It can be said that Du mastered the classical and contemporary poetic styles and that his poetry combines all the expertise that previous poets individually exhibited. If Confucius were to examine the themes of Du's poetry, he would highly praise Du's versatility. In my opinion, Fu Du was omnipotent in Chinese poetry. In Chinese history there has been no poet as versatile as him. [¼ ]"
2 One day Prime Minister An Xie of the Jin dynasty met his nephew and niece at a family gathering. Before long it started snowing. The prime minister asked them to describe the scene outside. His nephew replied, "It is almost like someone is throwing salt in the air." His niece, Dao-yun Xie, said, "That description is not as good as willow seeds [with white hair] riding on the wind." The prime minister was greatly pleased. Dao-yun Xie was actually the niece rather than the daughter of Prime Minister Xie. Yuan's wife, Hui-cong Wei, was the youngest daughter of Xia-qing Wei, the Prince's Guardian. Yuan is comparing his noble father-in-law to Prime Minister Xie and his talented late wife to Dao-yun Xie.
Yuan's wife, Hui-cong Wei, was a native of the national capital. After Wei died, Yuan wrote a poem to mourn her. It says, "Having experienced the great ocean, it is difficult to appreciate ordinary waters (The loving care of my late wife is like an ocean, which dwarfs other waters by comparison)./ Clouds above other places pale when compared with those above Wu Mountain." After twelve hundred years, these famous lines of Yuan's remain popular in China today.
3 Lou Qian of the State of Qi was a hermit. King Gong-gong of the State of Lu wanted to appoint him to be his prime minister. He refused the offer. The King of the State of Qi heard of Qian's talent and offered him two hundred pounds of gold if he would become his official. Qian also refused this offer. He lived in poverty all his life and wrote books on Taoism. When he died, he did not even have proper clothes to be buried in.
4 Yuan prepared his offerings in his family shrine.
5 Buddhists believe that one can deliver money to one's deceased relatives in the underworld by burning paper (fake) money.
6 You Deng of the Jin dynasty was the Mayor of He-dong City. In 312 CE, he fled from home because General Le Shi incited a rebellion against the government. As Deng fled, he encountered the rebel troops. The urgent situation forced him to choose between his son's life and his nephew's life. Deng chose his nephew's life because his nephew's father, Deng's younger brother, died young. Later, You Deng became the Mayor of Wu-jun City. He was kind, but never had a son again. His contemporaries lamented, "The negligence of the Creator causes Mayor Deng to have no sons." Here Yuan compares himself to Deng because his wife died and they had no sons.
7 Yue Pan was a poet of the Jin dynasty.

redpajama_set_name: RedPajamaCommonCrawl


text:
Departamento: Vinyl_Pop
Origen: Importado
Contenido: 1 Disco
Producto sujeto a disponibilidad y hasta agotar existencias
//add to wishlist
Recogelo en Tienda Mixup
//pickup on store
01.- BAD (SIDE A)
02.- THE WAY YOU MAKE ME FEEL (SIDE A)
03.- SPEED DEMON (SIDE A)
04.- LIBERIAN GIRL (SIDE A)
05.- JUST GOOD FRIENDS (SIDE A)
06.- ANOTHER PART OF ME (SIDE B)
07.- MAN IN THE MIRROR (SIDE B)
08.- I JUST CAN'T STOP LOVING YOU - MICHAEL JACKSON FEAT. SIEDAH GARRETT (SIDE B)
09.- DIRTY DIANA (SIDE B)
10.- SMOOTH CRIMINAL (SIDE B)
Limited vinyl LP repressing in gatefold jacket. Bad is the seventh solo studio album by Michael Jackson. It was released on August 31, 1987, nearly five years after Jackson's previous studio album, Thriller. Bad was recorded during the first half of 1987. The lyrical themes on the record relate to media bias, paranoia, racial profiling, romance, self-improvement and world peace. The album is widely regarded as having cemented Jackson's status as one of the most successful artists of the 1980s, as well as enhancing his solo career and being one of the best musical projects of his career. Five of the singles hit #1 in the United States, while a sixth charted within the Top Ten, and a seventh charted within the Top Twenty on the Hot 100. Bad peaked at #1 in thirteen countries and charted within the Top Twenty in other territories.
Deseo aclarar mis dudas acerca de este producto
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text:
Woman's Building of Houston - Milford House papers, 1894-1976
Finding aid note: Stored offsite at the Library Service Center and require 24-hour notice for retrieval. Please contact the Woodson Research Center at 713-348-2586 or woodson@rice.edu for more information.
The collection consists of the Woman's Building of Houston membership documents, including five membership registries, organizational notes such as meeting notes, administrative papers and election results, correspondence regarding membership, Certificates of Membership, and Certificates with letters concerning the transfer of memberships. Also present is memorabilia from Milford House and the Woman's Building of Houston, including programs and clippings relating to women's musical groups, operas and musicals, newspaper clippings concerning the history of the Woman's Building of Houston and events hosted at Milford House, a diary with notes on Milford House and other organizations, and a notebook containing listings of donations to Milford House.
Woman's Building of Houston (Organization)
This material is open for research.
Stored offsite at the Library Service Center and require 24-hour notice for retrieval. Please contact the Woodson Research Center at 713-348-2586 or woodson@rice.edu for more information.
Permission to publish material from the Woman's Building of Houston- Milford House papers must be obtained from the Woodson Research Center, Fondren Library.
In 1925, seventeen Houston women gathered to discuss the creation of a special building that would serve as a cultural and social center for Houston women. After years of planning, they announced a drive for the necessary $300,000 in 1928. "Men have their clubs, gathering places and organizations. Certainly the woman in this day need similar institutions," wrote a journalist in a April, 1928 Houston Chronicle article. The funds grew steadily, but the drive lost momentum over following two decades. In 1949, 39 of the 330 official members met to discuss the possibility of dissolving the organization. The members voted to continue the drive, and on Wednesday, November 11, 1953, Milford House was officially opened with a musicale and a tea. Milford House, officially operated by the Woman's Building of Houston, hosted many cultural and social events for women over the next two decades. The club membership dwindled in the 1980's, and Milford House, located at 1101 Milford, was sold to the Italian Cultural and Community Center of Houston in 1988. The club was disbanded shortly after.
1 Linear Feet ( (2 boxes))
The collection consists of the membership documents, organizational documents and memorabilia of the Woman's Building of Houston, an organization founded in 1925 that was devoted to the creation of a building that would serve as a cultural and social center for Houston women. After over twenty-five turbulent years of fundraising and patience, the organization saw success when Milford House officially opened in 1953.
The collection was a gift from Miss Mayola F. Patton, Rice 1922, via her sister and brother-in-law, Mr. And Mrs. Haylett O'Neill, Jr, on October 2, 1984.
Milford House
Records (documents)
Woman's Building of Houston
Texas-history. Texas and local history
Guide to the Woman's Building of Houston- Milford House papers, 1894-1976
Woman's Building of Houston- Milford House papers, 1894-1976, MS 388, Woodson Research Center, Fondren Library, Rice University. http://archives.library.rice.edu/repositories/2/resources/335 Accessed February 02, 2023.


Timelessly beautiful façade. With the visual appeal of natural timber and a minimum life expectancy of 50 years, Cedral is one of the most durable and low maintenance materials, allowing you to renovate your home with ease.
Cedral Colour Selector. Welcome to the Cedral Colour Selector. Register your details and you can: Upload your own projects. Request a sample. Download and share your project. Save a project and revisit it at a later time.
Easy to Install. Cedral needs to be fixed to timber battens of at least 50mm wide and spaced at a maximum of 600mm. Cedral should be fixed to at least three battens and must have a minimum 30mm clear cavity behind it.
Cedralsidings.com is tracked by us since October, 2016. Over the time it has been ranked as high as 848 699 in the world, while most of its traffic comes from Latvia, where it reached as high as 19 581 position.
Met Cedral sidings kies je voor een duurzaam en eigentijds materiaal. Geen wonder dat het dus vaak gekozen wordt bij renovaties om een mooi geheel te creëren tussen je nieuwe aanbouw, uitbouw of dakkapel en je bestaande woning. Maar wist je dat je ook een nieuwe woning volledig of gedeeltelijk van Cedral gevelstroken kan voorzien?
Cedral Sidings | Improve your house with a stylish facade cladding that will last forever. CEDRAL sidings are easy to install and require no maintenance at all.
Cedralsidings has a poor activity level in LinkedIn with only 20 mentions. Such a result may indicate a lack of SMM tactics, so the domain might be missing some of its potential visitors from social networks. As for Twitter and Facebook activity - Cedralsidings.com has - mentions and 0 likes.
While scanning server information of Cedralsidings.com we found that it's hosted by A100 ROW GmbH since January 31, 2018. Earlier Cedralsidings was hosted by Amazon Technologies Inc. in 2016.
Offrez à votre maison une façade intemporelle avec les planches Cedral. Ce revêtement est facile à poser et a besoin peu d'entretien. Une expansion ou une nouvelle construction?


text:
Lives on the Line: New Cookbooks 2020
By Liz Scheier |
These forthcoming culinary memoirs, all by industry professionals, offer glimpses into the kitchen and behind the bar.
Always Home
Fanny Singer. Knopf, Apr.
Recipes punctuate a series of intimate vignettes, lovingly told, about the quirks and genius of the author's mother, food activist and Chez Panisse restaurateur Alice Waters, who contributes the foreword. "Singer's language is read-out-loud luscious," PW's starred review said, "and her culinary coming-of-age story savory and sweet."
Eat a Peach
David Chang, with Gabe Ulla. Clarkson Potter, May
Before Chang achieved rock star status as the chef behind the Momofuku ("lucky peach") empire, he left the U.S. to teach English in a small village in Japan, looking for the meaning his undergraduate degree in religious studies didn't give him. It was there, in the throes of his first manic episode, that he realized his love of food and cooking could give purpose to his life. In his memoir, he writes of his struggle with mental illness, the luck and hard work that made him known as a culinary wunderkind, and his passion for, and uneasiness with, his chosen profession.
Our Lady of Perpetual Hunger
Lisa Donovan. Penguin Press, Aug.
Donovan, a Nashville pastry chef and James Beard Award–winning essayist, details her struggles to ascend in Southern kitchens where white men rose to fame and fortune on the backs of the women and people of color who preceded them, and about the family matriarchs who encouraged and inspired her and helped her forge a hard-driving life as a mother and an acclaimed chef. "Maybe," she writes, "if my relentlessness could do one thing, maybe it could break the boulder that my mothers carried for so long into small enough pieces that it would no longer feel like any of us were being buried alive."
Rebel Chef
Dominique Crenn, with Emma Brockes. Penguin Press, June
In 2018, Crenn became the first female chef in the U.S. to receive three Michelin stars, for her San Francisco restaurant Atelier Crenn. Her memoir tracks the years leading up to that milestone, from her childhood in Versailles, where her parents nurtured her curiosity and love of food; to the late 1980s, when she left the male-dominated culinary world of Paris for better opportunities in San Francisco; to her professional successes—the restaurant, her appearances on Iron Chef and Chef's Table—and her search for identity and belonging as an adoptee and an expat.
Unvarnished
Eric Alperin and Deborah Stoll. Harper Wave, June
Alperin, who among other projects cofounded influential L.A. bar the Varnish, and Stoll, a journalist and veteran bartender, slake readers' thirsts for a water-spots-and-all look at cocktail culture, with lessons learned from the late Sasha Petraske, a pioneering bartender and Alperin's mentor; musings on craft and what it means to be somebody's local; and cautionary advice against dating a bartender. Bolstering the narrative: 100 cocktail recipes that all Varnish bartenders know before they serve their first drink.
Return to the main feature.
A version of this article appeared in the 03/09/2020 issue of Publishers Weekly under the headline: Lives on the Line


Liz is a professional tour director, photographer, and traveler. She is so excited about this trip! Below is a loose schedule. We will not rush through the sights, we will take it slow, and try to take it all in. This trip will not be jammed packed! We will travel like a local and experience Prague the way it should be slow and steady.
All passes for: Prague Castle, Jewish Museum and grounds, St. Vitus Cathedral, Train ticket to Cesky Krumlov, Strahov Monastery, and the Funicular.
Day 1: Welcome! Dinner with the group.
Day 2: Walking tour with local guide.
This is a whirlwind tour to help you get an overview of Prague. We start at Wenceslas Square, wind our way through the ancient streets, find ourselves at the 400-year-old Astronomical Clock, views of Prague Castle, and cross the Charles Bridge. After the walking tour, we will stop for lunch and have free time. We will meet up later for the Christmas Market!
The Jewish quarter is soaked in history. We will start early and visit the synagog, museum, and graveyard. I will give you the history and what to expect the morning of. After this, we will stop for a coffee then head to 9th Century Prague Castle. Here we will have tickets to explore on your own with an English headset guide. After will be free time and we will meet up for more Christmas Market!
St. Vitus Cathedral is absolutely stunning. Build in 930 with the current construction 1033 this Cathedral will stick with you for years. From here we will go to the Funicular. This is so much fun. It is a gondola type of transportation that moves up the hillside slowly to a park that overlooks Prague. It's a postcard view. We will then stroll down to Strahov Monastery where we will sip Ale from the monastery that started it all. We will take a tour of the inside of the Monastery and peek inside the amazing golden library! Afternoon free time. We will meet up for MORE CHRISTMAS MARKET! Dinner out together.
This two-hour train ride will take us to the ancient bohemian town of Cesky Krumlov. Here we will visit the Bone Church, literally a church made of bones, and walk the ancient streets eating, shopping, and sightseeing as a group.
There is so much to do and see in Prague there is no way we will cover it all in just a week. For this day you can explore what interest you! I will give you suggestions on what to do, once we get to know each other a little bit.


text:
L'église Sainte-Anne de Sabarat est située sur la commune de Sabarat, en vallée de l'Arize, dans le département de l'Ariège, en France.

Localisation
Avec cimetière attenant, elle est située à l'Est et à l'écart du village, en surplomb du ruisseau de Menay.

Historique
Plusieurs églises se sont succédé avant de disparaître en ces lieux : Saint-Pierre-de-Molières est donnée à l'abbaye du Mas-d'Azil vers 1060 par Guillaume Aton de Fagolle, puis Saint-Martin-de-Crébacor, mentionnée en 1120 dans le cartulaire de l'abbaye du Mas-d'Azil.

L'église antérieure, où se trouvait encore un cloître en 1623, date du  siècle. Ruinée en 1625 lors des guerres de religion particulièrement vives dans la vallée de l'Arize, elle est reconstruite au  siècle et vraisemblablement terminée en 1688, date gravée sur le portail.

Le clocher-mur datant du  siècle avec cinq baies ouvertes sur trois niveaux, toutes dotées d'une cloche, est l'élément le plus remarquable malgré une rénovation avec un enduit lisse peu appropriée en façade.

Elle est inscrite partiellement pour son clocher-mur au titre des monuments historiques par arrêté du . L'église et son cimetière sont également un site classé depuis le 5 décembre 1944.

Description

Galerie

Valorisation du patrimoine

Références

Annexes

Articles connexes
 Liste des monuments historiques de l'Ariège.
 Liste des églises de l'Ariège.
 Liste des sites classés de l'Ariège.
 Liste des clochers-murs de l'Ariège.

Bibliographie
 David Cau-Durban, L'abbaye du Mas d'Azil (817-1774), Foix, Pomiès – et reédition Lacour.

Liens externes

Sabarat
Monument historique inscrit en 1944
Sabarat

redpajama_set_name: RedPajamaWikipedia


SAN FRANCISCO - (BUSINESS WIRE) - May 17, 2018 - Gap Inc. (NYSE: GPS) will provide a live audio webcast of the company's Annual Meeting of Shareholders, beginning at 10:00 a.m. Pacific Time on May 22, 2018. To register for the webcast on May 22, please visit www.gapinc.com (follow the Investors page, Webcasts). A replay of the presentation will be available through www.gapinc.com.
The webcast will provide the audio portion of the Annual Meeting of Shareholders only and does not constitute attendance. In order to vote at the Annual Meeting of Shareholders, shareholders must either authorize a valid proxy or attend the Annual Meeting of Shareholders and vote in person.


We want to make sure that the process of joining us at The Bedford Sixth Form is as simple as possible, so that from choosing your perfect courses to arriving on your first day you know exactly what stage your application is at.
When we receive your application you will be invited to attend an interview, where you will meet with a member of staff to answer any questions you may have about studying at The Bedford Sixth Form. Interviews will take place from January onwards.
Within five working days of your interview we will let you know if you have been successful and offer you a place at The Bedford Sixth Form for September.
After accepting your offer you will be invited to attend our welcome event, where you will have the chance to get an insight into life at The Bedford Sixth Form.
When you receive your GCSE results in August you can come along to our advice day, where our tutors will be on hand to discuss your options if your results aren't what you expected.
In early September you will be invited to the Sixth Form for enrolment, where you will confirm your GCSE results and finalise your offer of a place. After that you'll have everything you need to start your studies.
Once your application has been processed and accepted you will be invited to attend an interview at The Bedford Sixth Form – this is a chance for us to get to know you a little better and assess your suitability for the course you've applied for. It's also a valuable opportunity to chat to the tutor of your prospective course, who can answer any questions you may have about studying with us.
When you receive your invitation we will let you know when your interview will take place, so make sure you arrive in plenty of time – don't be late! It's also a good idea to familiarise yourself with the location of your interview – you will be asked to report to our main reception unless you are told otherwise. Take a look at our campus map to help you find the right place.
Nothing impresses an interviewer more than an enthusiastic and knowledgeable candidate, so before your interview have a think about what interests you about your chosen subject areas and how your chosen courses will help you achieve your goals.


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text:
require 'twitter/error'
require 'twitter/utils'
require 'twitter/version'

module Twitter
  class Client
    include Twitter::Utils
    attr_accessor :access_token, :access_token_secret, :consumer_key, :consumer_secret, :proxy
    attr_writer :user_agent
    deprecate_alias :oauth_token, :access_token
    deprecate_alias :oauth_token=, :access_token=
    deprecate_alias :oauth_token_secret, :access_token_secret
    deprecate_alias :oauth_token_secret=, :access_token_secret=

    # Initializes a new Client object
    #
    # @param options [Hash]
    # @return [Twitter::Client]
    def initialize(options = {})
      options.each do |key, value|
        instance_variable_set("@#{key}", value)
      end
      yield(self) if block_given?
      validate_credentials!
    end

    # @return [Boolean]
    def user_token?
      !!(access_token && access_token_secret)
    end

    # @return [String]
    def user_agent
      @user_agent ||= "TwitterRubyGem/#{Twitter::Version}"
    end

    # @return [Hash]
    def credentials
      {
        :consumer_key      => consumer_key,
        :consumer_secret   => consumer_secret,
        :token             => access_token,
        :token_secret      => access_token_secret,
        :ignore_extra_keys => true,
      }
    end

    # @return [Boolean]
    def credentials?
      credentials.values.all?
    end

  private

    # Ensures that all credentials set during configuration are of a
    # valid type. Valid types are String and Boolean.
    #
    # @raise [Twitter::Error::ConfigurationError] Error is raised when
    #   supplied twitter credentials are not a String or Boolean.
    def validate_credentials!
      credentials.each do |credential, value|
        next if value.nil? || value == true || value == false || value.is_a?(String)
        fail(Twitter::Error::ConfigurationError.new("Invalid #{credential} specified: #{value.inspect} must be a String."))
      end
    end
  end
end

redpajama_set_name: RedPajamaGithub


Recruitment and retention of participants for an international type 1 diabetes prevention trial : a coordinators' perspective.
Department of Pediatric Medicine, University of Pittsburgh, Pittsburgh, PA, USA.
Children's Hospital of Eastern Ontario Research Institute, Ottawa, ON, Canada.
Naomi Berrie Diabetes Center, Columbia University, New York, USA.
Montreal Children's Hospital, Montreal, QC, Canada.
Department of Endocrinology, Hospital for Sick Children, Toronto, ONT, Canada.
Department of Endocrinology and Diabetes, The Children's Hospital at Westmead, Sydney, NSW, Australia.
BACKGROUND: The Trial to Reduce Insulin Dependent Diabetes Mellitus in the Genetically at Risk (TRIGR) is the first multicenter international type 1 diabetes (T1D) prevention trial to be undertaken. A unique feature of TRIGR has been recruitment of eligible pregnant women and enrollment of newborns for long-term follow-up assessments.
PURPOSE: Our purpose is to summarize the recruitment and retention strategies used to conduct TRIGR from the perspective of the study coordinators.
METHODS: TRIGR was designed to test whether weaning to formula containing hydrolyzed versus intact cow's milk protein would be efficacious in decreasing risk for development of T1D-associated autoantibodies and T1D among infants identified to be at increased risk for T1D based on their human leukocyte antigen (HLA) profile and family history. Multiple strategies tailored to local issues were required to enroll and follow the target number of infants.
RESULTS: This study was conducted in the United States, Canada, Australia, and 12 countries in Europe. Of the 5606 mothers registered worldwide, 5000 of their infants were randomized. Of these, 2159 were HLA eligible and enrolled in the 8-month intervention and 10-year follow-up phases of this study. The TRIGR study met the accrual goal after 4.7 years of recruitment, 2.7 years longer than projected initially. Challenges included difficulty in finding fathers with T1D, a higher than expected rate of premature delivery among T1D mothers, and implementation of new privacy regulations mid-trial. The majority of participants were recruited from primary care antenatal clinics located near the study centers and from a general hospital or pediatric center that was affiliated with a TRIGR Study center. Internet and magazine advertisements were found to be useful for recruitment of families. Alternative follow-up strategies are offered to families who wish to reduce or discontinue participation.
LIMITATIONS: Our experience is limited to a single international multicenter trial.
CONCLUSIONS: TRIGR coordinators played key roles in the recruitment and intervention periods and continue to be instrumental in retaining families and children during the 10-year follow-up period for each child.


When the walkie-talkie is used in the security department, the security workers have higher requirements for the security of the information transmission of the walkie-talkie. This RT5 walkie talkies can meet your needs. We take the security department as an example. The specific methods will be presented below.
Retevis RT5 two-way radio 7W VHF / UHF dual-band 128CH walkie-talkie, so there are many frequencies for the security department to choose. Security workers can easily adjust the frequency and sub-audio for double encryption, or set the receive frequency and transmit frequency to make the security information more secure.


If a band is described as "one of the best live bands in the world" by the former manager of The Ramones, you can safely assume there's something pretty special about them. Whether you believe the considerable hyperbole surrounding East London trio False Heads or not, there's no denying that in counting the likes of punk royalty Iggy Pop among their fans, they should be guaranteed at least more than a passing listen.
Having been a going concern for barely two years, False Heads' sound spans the angst-ridden overdriven guitars of Comfort Consumption to Thick Skin's snotty ripostes, Slew's ponderous bass and the Nirvana-esque TwentyNothing, which signals a carefully restrained rage that's bound to be unleashed on the live stage.
The band will be performing at Stockton's Ku Bar on Friday 14th September, accompanied by a couple of well-chosen local supports in Middlesbrough's SWEARS, whose own accessible scuzzy and doomy noise pop has been known to cause a live ruckus, plus Teesside's Heel Turn, stern proponents of the region's DIY scene with their own Sad For Life Records label.
What's more, the afterparty promises two rooms of indie anthems and floor fillers guaranteed to get your weekend off to a noisy start. Get on it.


text:
is a railway station on the Nippō Main Line operated by JR Kyushu in Kitsuki, Ōita, Japan.

Lines
The station is served by the Nippō Main Line and is located 85.2 km from the starting point of the line at .

Layout
The station, which is unstaffed, consists of two side platforms serving two tracks. Approaching from the direction of , the double tracks of the Nippō Main Line are widely separated and converge to meet at the station, with the two platforms thus forming a V-shape. The station building is a modern concrete structure and serves only to house a waiting area and an automatic ticket vending machine. Access to the opposite side platform is by means of a footbridge located near the vertex of the "V".

Adjacent stations

History
The private Kyushu Railway had, by 1909, through acquisition and its own expansion, established a track from  to . The Kyushu Railway was nationalised on 1 July 1907. Japanese Government Railways (JGR), designated the track as the Hōshū Main Line on 12 October 1909 and expanded it southwards in phases, with  opening as the new southern terminus on 15 December 1910. On the same day, Tateishi was opened as an intermediate station on the new track. On 15 December 1923, the Hōshū Main Line was renamed the Nippō Main Line. With the privatization of Japanese National Railways (JNR), the successor of JGR, on 1 April 1987, the station came under the control of JR Kyushu.

Passenger statistics
In fiscal 2015, there were a total of 12,724 boarding passengers, giving a daily average of 35 passengers.

See also
List of railway stations in Japan

References

External links

Railway stations in Ōita Prefecture
Railway stations in Japan opened in 1910


text:
Definitions for "ALLEGIANCE"
Keywords: sovereign, loyalty, citizen, rightly, anointed
Related Terms: Amnesty, Defection, Treason, Political asylum, Asylum, Subject, Liberty, Refugee, Citizen, Fealty, Legitimacy, Justice, Free, Boycott, Exile, Anarchist , Profess, Aclu, Asylum seeker, Condemned, Sufferance, Denizen, Civil disobedience, Proscription, Forgive, Freedom, Homage, Asylee, Wardship, Acquiescence, Rights, Civil liberty, Ambassador, Sanction, Human rights, Alien , Citizenship, Autocracy, Liberty, Tyranny, Taboo, Punishment, Statesman, Civil rights, Confiscation, Expatriation, Remission, Retribution, Liberal, Loyal
This thing Allegiance, as I suppose, Is a ring fitted in the subject's nose, Whereby that organ is kept rightly pointed To smell the sweetness of the Lord's anointed. G.J.
gutenberg.org
The tie or obligation, implied or expressed, which a subject owes to his sovereign or government; the duty of fidelity to one's king, government, or state.
Devotion; loyalty; as, allegiance to science.
Loyalty to a nation, organization, or cause.
allaboutspace.com
the act of binding yourself (intellectually or emotionally) to a course of action; "his long commitment to public service"; "they felt no loyalty to a losing team"
the loyalty that citizens owe to their country (or subjects to their sovereign)
Allegiance is the duty which a subject or a citizen owes to the state or to the sovereign of the state to which he belongs.
Keywords: mmog, zahn, teamwork, timothy, hardcover
Allegiance is an MMOG providing a mix of real-time strategy and player piloted space combat. Initially developed by Microsoft Research, the game was later released under a shared source license and is now maintained/developed by volunteers. Gameplay relies heavily on good teamwork and forward thinking.
Allegiance is a novel set in the Star Wars galaxy that was just released by Del Rey. The book was written by Timothy Zahn, and it takes place directly after the ending of A New Hope. The book is available only in hardcover, but will later be in paperback.
"Allegiance" is the title of an episode from the third season of Star Trek: The Next Generation.
Keywords: pact, quest, fellowships, permanent, semi
a permanent relationship you make with other players
classic.zone.msn.com
a semi-permanent pact between players, while fellowships last only for a single quest
Keywords: luxons, kurzicks, joining, refers
Refers to joining either the Luxons or the Kurzicks.
gw.gamewikis.org
Keywords: unbeatables, best, guys, american, available
The best air conditioner in the business. Available from the Unbeatables at A & H Service, Co.
ahservice.com
The best air conditioner available today. Available only from American Standard.
americanstandardair.com
The best air conditioner in the business. Available only from the good guys at American Standard.
concordairconditioning.com
Keywords: perth, australia, western, heavy, band
Allegiance were a heavy metal band from Perth, Western Australia.


text:
Understanding genetic testing for hereditary disease
By Rod Nowakowski, OD, PhD, FAAO
Genetic testing is becoming more successful and is expanding in scope. Understand how the process works and how to guide your patients through it. Find out what is involved and how to manage genetic testing…plus access a list of resources for you and your patient.
Diagnosis at the molecular level is quickly becoming standard of care. The national initiative in precision medicine will rely heavily on genetic diagnoses by taking into account "individual differences in people's genes."1
Gene therapy and genetic-based trials are increasing rapidly in success and number and are expanding in scope and concept. Gene therapy with Luxturna (Spark Therapeutics) for Leber congenital amaurosis received FDA approval December 19, 2017,2 and the first patient was treated on March 20, 2018.3 Eligibility for treatment includes biallelic mutations in the RPE65 gene confirmed by genetic testing.
It is incumbent on the practitioner to recognize potentially hereditary eye disease and discuss referral for genetic testing. Realize that not every patient will want genetic testing.
Two concerns with genetic testing are protecting privacy and-related to that-avoiding possible discrimination by employers. Title II of the Genetic Information Nondiscrimination Act of 2008 (GINA) became effective in 2009 and prohibits employment discrimination based on genetic information.4 This fact might reassure some patients, but others will have different concerns; they should know that genetic testing can be performed later if they change their minds. Consultation with a genetic counselor or medical or clinical geneticist might help them with this decision without committing them to testing.
Molecular level diagnosis
Retinitis pigmentosa serves as a good example of why diagnosis at the molecular level is important. In 2013, Daiger et al reported that over 3,100 known mutations, within about 50 genes, cause what we call retinitis pigmentosa clinically.5 That means over 3,100 different diagnoses could be made, and it is no longer sufficient to diagnose "retinitis pigmentosa" without offering genetic testing that could refine the diagnosis to the molecular level.
"Could" is the operative word because we may test and find nothing. If there are 3,100 known mutations, maybe there are actually 6,100 but we don't know the other 3,000 so those may not show up with current test strategies. Or, if there are 50 known genes, maybe there are another 50 we don't know about yet and hence may not get tested. These are overly simplistic examples, but it adequately conveys the concern that we may test someone with clinical retinitis pigmentosa but not find a causative gene mutation.
Related: Current views on genetic testing for AMD
Gene or mutation-based therapies are being investigated and are having some success. Eligibility criteria for various clinical trials often states that candidates must have a confirmed diagnosis through genetic testing-another good reason for testing. Because results from genetic testing can take two to three months, it seems reasonable for a patient to get testing done so he has that information when or if a clinical trial comes along that interests him. The best resource for discovering what types of clinical trials are taking place is ClinicalTrials.gov (see "Genetic testing resources for ODs and patients" box).
Some, including third-party payers, may argue that genetic testing has little applicable value unless there is a direct connection to treatment; however, that is a very myopic view of what constitutes "treatment."
The American College of Medical Genetics and Genomics (ACMG) points this out in a policy statement on the clinical utility of genetic and genomic services stating that: "…etiologic diagnosis prevents additional unnecessary testing, provides the opportunity for anticipatory guidance, and provides better information regarding recurrence risks for the family and the affected individual. Further, as increased numbers of individuals are diagnosed with specific genetic disorders, information will be obtained that will help predict future complications and risks, tailor medical interventions, and lead to the development of new specific therapies and management strategies."6
Patient perceptions of the personal value of genetic testing that provided meaningful results from one study included four qualities:7
• Achieving a sense of empowerment over their own health
• Achieving a sense of legitimization of their suffering by no longer being a mystery or curiosity
• Achieving a sense of doing all that you can for your child, yourself, or family member(s)
• Achieving a sense of altruism by contributing to society to help others
Other patients have expressed relief at ending a "diagnostic odyssey" of multiple doctors' visits and possibly unnecessary diagnostic testing, all with no answers and achieving hope where before there was none when a cause is found
What is involved
A patient interested in genetic testing will be referred to a medical or clinical geneticist experienced in eye disease. The evaluation will include a detailed history and construction of a family pedigree as well as a pathology-focused eye exam and additional testing to help determine what genetic test will be ordered provided that the patient wants to pursue it and gives informed consent.
Informed consent is an important first step. The patient needs to understand why testing is recommended and the potential outcomes-both pros and cons.
Related: How a newly-discovered gene affects myopia
The test order form will have one or more areas for the patient to give consent for testing, stating that she understands the reason for the test and possibly for allowing her anonymized DNA to remain in a repository to be used for research.
Testing is not necessarily benign, and there can be adverse effects. For example, it may confirm a diagnosis with a poor prognosis when the patient was hoping it would do the opposite. It could reveal non-paternity or an additional genetic variant that was not suspected. The patient should understand this before agreeing to testing.
Possible test outcomes
Any sequence alteration in DNA is usually reported as a "variant," not as a "mutation." This avoids the common misperception that a mutation is always disease-causing when in fact it might be benign.
It has been recommended that variants be reported with the following modifiers: pathogenic, likely pathogenic, uncertain significance, likely benign, or benign.8 These modifiers convey the important message that test results may carry a certain degree of uncertainty or even that nothing may be found. Again, it is important that patients understand these possibilities as part of the informed consent process prior to testing.
The sample collected is about 3-10 mL of blood from routine venipuncture of the arm. DNA is isolated from the white blood cells, and the DNA is tested. DNA can also be isolated from cells collected by a buccal smear or from cells collected from a special mouth wash. For infants, blood can be collected onto an absorbent paper following a heel stick with a sterile lancet.
Ordering the test
The desired test is ordered from a Clinical Laboratory Improvement Amendments (CLIA)-certified laboratory-and this is where it gets complicated. Testing requires a knowledgeable practitioner, typically a medical or clinical geneticist, because there are many different tests and the outcomes can be quite complex.
Related: Using OCTA in optometric practice
For example, one cannot order a "genetic test for retinitis pigmentosa." Order forms are often lengthy, and laboratories may request a medical summary, family pedigree, and specific eye findings that will be reviewed to be sure the requested test is appropriate.
Genetic testing often takes 8 to 12 weeks but varies depending on what test is ordered. Insurance, with a few exceptions, typically does not cover genetic testing for hereditary eye disease.
Costs may vary from a few hundred dollars to a few thousand dollars. Cost also varies among laboratories, and some labs offer payment plans or fee adjustments based on financial need.
An experienced medical geneticist or certified and experienced genetic counselor can be helpful in sorting out the options.
Genetic test results can be complex and difficult to interpret. The best practice is to review results face-to-face with the patient even if nothing was found.
My preferred procedure is to prepare a folder of information that the patient can take home. It contains a copy of the lab report, a summary of affected gene(s), and a summary of the disorder. Both summaries come from Genetics Home Reference (see other resources), which is an excellent source of information from the National Institutes of Health about all aspects of medical genetics.
The folder also includes a copy of the pedigree as determined at the initial clinic visit and a list of resources for further information. Each of these is reviewed in detail. The pedigree is reviewed to determine which, if any, family members might be at-risk to be a carrier or be affected but not yet diagnosed.
"Targeted" genetic testing can be offered to these individuals for the specific variant found in the initial patient. Targeted testing is usually less expensive because the lab already knows what to look for. This leads to a discussion of recurrence risk for the patient's offspring, and it might be necessary to also test the patient's parents before that can be assessed. Two other topics to address are prognosis and current or possibly future treatments, including gene therapy. All of this takes time and may require another visit.
The prospects of gene or mutation-based treatments including gene therapy are exciting, but meanwhile it is important to not overlook traditional aspects of management including maximizing vision with glasses or contact lenses, referral for low vision rehabilitation, referral for vocational rehabilitation services, as well as periodic eye exams to monitor progression and to not miss other ocular disorders.
Where we are headed
Diagnosis at the molecular level will likely become standard of care, and treatment with gene therapy may eventually have the potential to cure or restore substantial sight to those with many types of hereditary eye disease. Driving forces are the emphasis in precision medicine, advances in gene editing techniques, and the evolving success of gene or gene-based therapy
It seems likely that FDA-approved gene therapy for additional hereditary ophthalmic disorders will occur within the next several years. For many, eligibility for clinical trials and eventual treatments will begin with genetic testing.
Related: 6 things you need to know: Genetic markers for glaucoma identified
1. WhiteHouse.gov. The Precision Medicine Initiative. Available at: https://obamawhitehouse.archives.gov/precision-medicine. Accessed 3/27/18.
2. U.S. Food & Drug Administration. FDA approves novel gene therapy to treat patients with a rare form of inherited vision loss. Available at: https://www.fda.gov/NewsEvents/Newsroom/PressAnnouncements/ucm589467.htm. Accessed 3/29/18.
3. Massachusetts Eye and Ear. Mass. Eye and Ear performs first FDA-approved gene therapy procedure for inherited disease. Available at: https://www.masseyeandear.org/news/press-releases/2018/03/mass-eye-and-ear-performs-first-fda-approved-gene-therapy-procedure. Accessed 3/29/18.
4. U.S. Equal Opportunity Employment Opportunity Commission. Genetic Information Discrimination. Available at: https://www.eeoc.gov/laws/types/genetic.cfm. Accessed 3/27/18.
5. Daiger SP, Sullivan LS, Bowne SJ. Genes and mutations causing retinitis pigmentosa. Clin Genet. 2013 Aug;84(2):132-41.
6. ACMG Board of Directors. Clinical utility of genetic and genomic services: a position statement of the American College of Medical Genetics and Genomics. Genet Med. 2015 Jun;17(6):505-7.
7. McCormick J, Halverson C, Clift K. Was it worth it? Patients' views on the value of clinical genomic sequencing. (Platform Presentation in Whole Exome Sequencing), American College of Medical Genetics Annual Meeting, Tampa, FL, March 10, 2016.
8. Richards S, Aziz N, Bale S, Bick D, Das S, Gastier-Foster J, Grody WW, Hegde M, Lyon E, Spector E, Voelkerding K, Rehm HL; ACMG Laboratory Quality Assurance Committee. Standards and guidelines for the interpretation of sequence variants: a joint consensus recommendation of the American College of Medical Genetics and Genomics and the Association for Molecular Pathology. Genet Med. 2015 May;17(5):405-24.
9. Health conditions related to genetic changes. Genetics Home Reference. Available at: https://ghr.nlm.nih.gov/gene/BEST1#conditions. Accessed 3/27/18.
10. National Ophthalmic Disease Genotyping and Phenotyping Network. About eyeGENE. Available at: https://eyegene.nih.gov/about. Accessed 3/27/18.


text:
/**
 *  Dependencies
 */
#include "includes.h"

/**
 *  Set up namespace
 */
namespace AMQP {

/**
 *  Report success, a get message succeeded and the message is expected soon
 *  @param  messageCount    Message count
 *  @return Deferred
 */
const std::shared_ptr<Deferred> &DeferredGet::reportSuccess(uint32_t messageCount) const
{
    // we grab a self pointer to ensure that the deferred object stays alive
    auto self = shared_from_this();

    // we now know the name, so we can install the message callback on the channel, the self
    // pointer is also captured, which ensures that 'this' is not destructed, all members stay
    // accessible, and that the onFinalize() function will only be called after the message
    // is reported (onFinalize() is called from the destructor of this DeferredGet object)
    _channel->install("", [self, this](Message &&message, uint64_t deliveryTag, bool redelivered) {

        // install a monitor to deal with the case that the channel is removed
        Monitor monitor(_channel);

        // call the callbacks
        if (_messageCallback) _messageCallback(std::move(message), deliveryTag, redelivered);

        // we can remove the callback now from the channel
        if (monitor.valid()) _channel->uninstall("");
    });

    // report the size (note that this is the size _minus_ the message that is retrieved
    // (and for which the callback will be called later), so it could be zero)
    if (_sizeCallback) _sizeCallback(messageCount);

    // return next object
    return _next;
}

/**
 *  Report success, although no message could be get
 *  @return Deferred
 */
const std::shared_ptr<Deferred> &DeferredGet::reportSuccess() const
{
    // report the size
    if (_sizeCallback) _sizeCallback(0);

    // check if a callback was set
    if (_emptyCallback) _emptyCallback();

    // return next object
    return _next;
}

/**
 *  End of namespace
 */
}


All projects have different timeframes. What we can tell you though is that when we work on your project, it will receive our 100% full attention from commencement to completion. We will always provide an accurate estimate of turnaround time prior to commencement, however, things such as weather conditions may sometimes affect this.
How long in advance do I need to schedule my landscaping project to be done?
This is seasonal and can depend on other projects at the time. Generally speaking, Patrick and the team are available to work on small and medium projects within 2 weeks of a booking being requested.
Where do you source materials used on projects from?
Where possible, materials are sourced from Patrick's garden centre - Glebe Gardens. Wehave a huge range of products from our gravel yard, nursery and gift shop that can give any job an amazing finish. Other materials may be sourced from local businesses on a case-by-case basis.
Our committment to you is that the job is not complete until YOU are happy with the outcome.
Who will I deal with throughout my project?
In 90% of cases, you will always be able to deal directly with Patrick Graham throghout your project. If Patrick is unavailable, you will be introduced to a project manager who can be your main point of contact.
What are your payment terms for landscaping projects?


text:
The Truth About DIY Bio Labs
Future of You
Danielle Venton
A microbial fuel cell on display at the 2015 Maker Faire. Microbial fuel cells convert organic matter to electricity by using bacteria. (Courtesy of BioCurious and CounterCulture Labs/Flickr user Daniel Ge )
It's a truism that we distrust what we don't understand. Let me confide something.
I grew a lot of yeast and bacteria in my college lab. Between raising and killing these living organisms, I explored and shaped them, tinkering with their DNA to make them glow, resist an antibiotic or digest a new nutrient.
Yet when the DIY bio phenomenon burst into the popular science press a couple of years ago, my first thought was: Should they be allowed to do this? What if they create a dangerous pathogen and launch a deadly epidemic? Pretty much what all the media started imagining. In 2009 the Wall Street Journal ran the hair-raising headline "In Attics and Closets, 'Biohackers' Discover Their Inner Frankenstein."
Offerings from just this year include:
Inside the Garage Labs of DIY Gene Hackers, Whose Hobby May Terrify You (Fusion)
Accessible Synthetic Biology Raises New Concerns for DIY Biological Warfare (Motherboard)
"People seem to think that we're not concerned about safety," says Eric Harness, director of lab operations and safety at BioCurious, a community lab in Sunnyvale.
I'd found Harness at a conference in Oakland billed as BioHACK THE PLANET, and told him my editor and I were particularly intrigued by a portion of Sunday's program titled "Bad things happen - are you prepared?"
Harness was unsurprised. That's what every member of the press wants to talk about, he said.
As it turns out, the subject is far less juicy than you might expect.
According to a 2013 survey titled "Seven Myths and Realities about Do-It-Yourself Biology" by the Woodrow Wilson International Center for Scholars in Washington, D. C., the vast majority of DIYers work with non-toxic, non-harmful organisms approved for biosafety level 1 research. Just like a high school lab.
Rather than working anonymously and solitarily, the report finds, DIYers overwhelmingly use group lab space. Many are still learning the basics of biology and don't have knowledge or tools of an advanced virologist. More importantly, lab directors keep an eye on all materials purchased, brought in, and removed from the lab, providing an obstacle to anyone trying to do secret nefarious "Frankensteinian" work.
Granted, it would be naive to suggest something couldn't go wrong. A workshop in August held by the Center for Global Security Research concluded that self regulation of community labs is working well so far, while also acknowledging that probability of an "unfortunate incident" increases as the DIY bio community continues to grow. (Read the workshop report.)
One idea under consideration is the creation of a "soft" safety licensing program for unaffiliated researchers, similar to amateur radio FCC licensing. Another recommendation from the workshop is that DIY labs create a code of conduct and establish relationships with local fire departments, public health officials and law enforcement.
Independent experimenters, working in their garages and kitchens, seem to trigger the greatest fears. And while these DIY-ers may fly under the radar (no one can control what you do in you garage after all), the report suggests we're probably more fearful that we need to be.
"Early narratives created by some writers and opinion-makers presented the notion of a lone 'biohacker' in a garage laboratory surreptitiously working with—or creating—dangerous pathogens," says the CGSR report. This is likely a "greatly exaggerated threat" the authors conclude, as it generally assumes amateurs in home labs can do what cannot yet be done by professional biologists in institutional settings.
Creativity, Unleashed
Patrik D'haeseleer, self-described "cat herder" at Counter Culture Labs, works a day job as a computational scientist at Lawrence Livermore National Laboratory.
"I've worked my whole career side by side with experimental biologists and I've always regretted not having the chance to build up that side of the skills as well," he told me. "So when I first heard about DIY bio I jumped on that. It's liberating. It's really energized my own career, because it opens up a field of creativity where I can just play around with things and try things out in the lab."
If he gets a cool idea on Saturday he might be working on it come Monday. In his professional career, he says by contrast, "at a very minimum it would be at least a year before we can actually work on it."
DIY biologists are currently working on such cool ideas as 'real vegan cheese' by coaxing baker's yeast into expressing milk protein. Someone is at work on an EpiPencil, which would cost $30, instead of the hundreds charged for an EpiPen. Others are working to develop more affordable generic medical treatments, such as insulin for diabetics, or estrogen for trans women. (Before reaching the market, these products would require normal regulatory approval.)
Eri Gentry, co-founder and president of BioCurious (she works a day job at Institute for the Future too), says she sees a current lack of investment in basic research and development. Her hope is to make biological research accessible to more people, broaden the playing field and spur more innovation.
"I'm hoping that we'll see more solutions for mankind," Gentry says.
Biotech will be the technology of this century D'haeseleer says. "It's going to affect our lives just as much or more as computers have."
D'haeseleer points to CRISPR, a gene-editing technique which has raised both widespread hope and alarms.
"To me, it's just a better screwdriver," D'haeseleer says. "There's lots of [good or bad] stuff you could do with a better screwdriver and it's probably those things you should be worried about and not the screwdriver."


text: Q: How is it possible for a human eye to see the entire reticle in a reflector sight? Reflector sights such as used on fighter planes project an image of a reticle "focused at infinity", that is, whose rays are parallel, onto a semi transparent window. How is it possible for a human eye to see the image of the whole reticle, when the reticle is bigger than the human eye itself (typically the size of the sight window, around 10 centimeters across)? If the rays are parallel then only a part of the reticle, the size of retina should be visible


text:
' Licensed to the .NET Foundation under one or more agreements.
' The .NET Foundation licenses this file to you under the MIT license.
' See the LICENSE file in the project root for more information.

Imports Microsoft.CodeAnalysis.Text
Imports Microsoft.CodeAnalysis.Utilities
Imports Microsoft.CodeAnalysis.VisualBasic.CodeGeneration
Imports Microsoft.CodeAnalysis.VisualBasic.Syntax

Namespace Microsoft.CodeAnalysis.VisualBasic.Wrapping.SeparatedSyntaxList
    Partial Friend Class VisualBasicParameterWrapper
        Inherits AbstractVisualBasicSeparatedSyntaxListWrapper(Of ParameterListSyntax, ParameterSyntax)

        Protected Overrides ReadOnly Property Align_wrapped_items As String = FeaturesResources.Align_wrapped_parameters
        Protected Overrides ReadOnly Property Indent_all_items As String = FeaturesResources.Indent_all_parameters
        Protected Overrides ReadOnly Property Indent_wrapped_items As String = FeaturesResources.Indent_wrapped_parameters
        Protected Overrides ReadOnly Property Unwrap_all_items As String = FeaturesResources.Unwrap_all_parameters
        Protected Overrides ReadOnly Property Unwrap_and_indent_all_items As String = FeaturesResources.Unwrap_and_indent_all_parameters
        Protected Overrides ReadOnly Property Unwrap_list As String = FeaturesResources.Unwrap_parameter_list
        Protected Overrides ReadOnly Property Wrap_every_item As String = FeaturesResources.Wrap_every_parameter
        Protected Overrides ReadOnly Property Wrap_long_list As String = FeaturesResources.Wrap_long_parameter_list

        Public Overrides ReadOnly Property Supports_UnwrapGroup_WrapFirst_IndentRest As Boolean = True
        Public Overrides ReadOnly Property Supports_WrapEveryGroup_UnwrapFirst As Boolean = True
        Public Overrides ReadOnly Property Supports_WrapLongGroup_UnwrapFirst As Boolean = True

        Protected Overrides ReadOnly Property ShouldMoveCloseBraceToNewLine As Boolean = False

        Protected Overrides Function FirstToken(listSyntax As ParameterListSyntax) As SyntaxToken
            Return listSyntax.OpenParenToken
        End Function

        Protected Overrides Function LastToken(listSyntax As ParameterListSyntax) As SyntaxToken
            Return listSyntax.CloseParenToken
        End Function

        Protected Overrides Function GetListItems(listSyntax As ParameterListSyntax) As SeparatedSyntaxList(Of ParameterSyntax)
            Return listSyntax.Parameters
        End Function

        Protected Overrides Function TryGetApplicableList(node As SyntaxNode) As ParameterListSyntax
            Return node.GetParameterList()
        End Function

        Protected Overrides Function PositionIsApplicable(
                root As SyntaxNode, position As Integer, declaration As SyntaxNode,
                containsSyntaxError As Boolean, listSyntax As ParameterListSyntax) As Boolean

            Dim generator = VisualBasicSyntaxGenerator.Instance
            Dim attributes = generator.GetAttributes(declaration)

            ' We want to offer this feature in the header of the member.  For now, we consider
            ' the header to be the part after the attributes, to the end of the parameter list.
            Dim firstToken = If(attributes?.Count > 0,
                attributes.Last().GetLastToken().GetNextToken(),
                declaration.GetFirstToken())

            Dim lastToken = listSyntax.GetLastToken()

            Dim headerSpan = TextSpan.FromBounds(firstToken.SpanStart, lastToken.Span.End)
            If Not headerSpan.IntersectsWith(position) Then
                Return False
            End If

            If containsSyntaxError AndAlso ContainsOverlappingSyntaxErrror(declaration, headerSpan) Then
                Return False
            End If

            Return True
        End Function
    End Class
End Namespace


Pieces of Her selected as a finalist in the Wilda Hearne Flash Fiction Contest.
~~In the sitting room she began tearing a hundred little pieces of paper. On each piece she wrote a note to him. A note of endearment, a note of special secrets they shared, notes of encouragement, of their future, things that made them laugh, of amorous nights, one that simply said LOVE. Each note was a part of her, each note was different. She could feel her presence diminishing with each letter and each word.
An Unsent Letter recognized in the Proud To Be short story anthology Vol. 3 - Southern Missouri State University Press.
~~But I know better, I sweated and laughed and cried with the old face. Drank shots and chased women. The new face doesn't do that. The new face hides the old eyes that are now vacant, maybe so filled with something so big that the new face is unable to give words to it so the eyes just give up and become black holes, sucking everything in, but letting nothing out.
Four Shots and Three Funerals recognized as the short story finalist in the Proud To Be short story anthology Vol. 4 - Southern Missouri State University Pres.
~~ Have you ever watched a widow or mother during the 21-gun salute," asked the stranger? Weasel shook his head from side to side, fearing to make anything more than a subtle gesture.
PERFORMANCE PSYCHOLOGIST - RESEARCHER - WRITER: My passion is optimizing performance in every domain of human endeavor and illuminating the human condition. Work with me and experience what is possible.
Remember - Put your mind on what matters.
Copyright 2013. dutch franz. All rights reserved.


The Ministry of Public Health of Cameroon advises mothers to follow the World Health Organization's recommendation of exclusive breastfeeding during the first six months of life and to continue breastfeeding along with appropriate complementary foods up to two years or beyond. Despite these recommendations, malnutrition due to inadequate feeding practices is still prevalent in Cameroon. Therefore, this study aims to explore infant feeding perceptions and identify factors influencing infant feeding practices in Cameroon. Forty-nine women aged 19 to 38 who had infants aged 6 days to 15 months were purposively selected from hospitals during the vaccination days and interviewed until saturation. The research tools included six qualitative group interviews, with each group comprising 6 to 10 women. The study was conducted in the rural area of Bandja and the urban areas of Yaoundé and Bamenda. Data were analysed using content analysis. In the study, breastfeeding was agreed upon as the best way to feed infants and was commonly practised for 1 to 2 years. Nevertheless, few infants were breastfed exclusively. Complementary foods were often nutritionally inadequate; many children were not given fruit, vegetables or foods of animal origin on a daily basis. Cultural beliefs, tradition, community norms and low educational and economic levels negatively influenced the implementation of appropriate infant feeding recommendations. The short duration of exclusive breastfeeding and the poor food diversity are the main problems. In response, it is necessary to strengthen the position of women, increase the period of maternal leave, introduce sustainable and practical education for both parents about breastfeeding, and provide good, local complementary foods.


As a follow up to our FAQ on Why doesn't the title and description I set appear in search results?, this article describes how you can check your index status in Google search results.
So first the why: Why do you need to check your index status?
The answer is that you spend time optimizing your site for search engines and you want to know when those changes are reflected in search results. For example, you change a Meta Description for a page to comply with Google's Quality Guidelines, but when you check Google search results, the change is not reflected. This is because search engines don't have to update their index for your site every time you make a change. It could take days, weeks or even in some cases, months for search engines to update their index to reflect a change you made. Knowing how often they update their index is therefore very important.
So now the how: How do you check the frequency by which Google updates their index for your site?
Now click on the "Sorted by relevance" dropdown that has appeared and select "Sort by date".
You will now see the familiar search results but limited to just your site for the past year sorted by last updated, most recent at the top. From this screen you can now work out how often Google updates their index for your site by checking the last updated date next to each result.
If the result of the steps above shows that the period between last updated dates is too great, say more than 1 month, then you may want to consider trying to influence Google to update their index more frequently. The main way to do this is by posting content more regularly. The more regularly you post content, the more regularly Google will crawl your site and the more regularly they will update their index. Make sure you submit your XML Sitemap to Google via Google Search Console, and make sure you set the Schedule Updates frequency in the XML Sitemap module that is close to the frequency you post/update your content.


text:
Home / Africa / Northern Africa / Egypt / Sharm El Sheikh
Crete 883494
Lanzarote 670269
Benidorm 608461
Fuerteventura 550945
Playa de las Americas 436125
Corfu Town 405174
Gran Canaria 361024
Sunny Beach 233535
Menorca 218357
Benalmadena 212889
Albufeira 211709
Costa Adeje 202049
Paphos 200910
Tenerife South 200235
Riviera Maya 191607
Vilamoura 176646
Holidays in Sharm El Sheikh
Flights to Sharm El Sheikh
Sharm El Sheikh Weather Forecast, Egypt
The warmest day over the next 25 days weather in Sharm El Sheikh is forecast to be Tuesday 26th January 2021 at 24°C (75°F) and the warmest night on Friday 29th January 2021 at 17°C (63°F). The average temperature over the next 25 days in Sharm El Sheikh from this forecast is 21°C (70°F) and there will be 14 days of sunshine . The average for January is 18°C (64°F).
Thu 21 Jan 18°C (64°F)
N 11mph
(17kmh)
Night 13°C
(55°F)
Fri 22 Jan 19°C (66°F)
N 7mph
Sat 23 Jan 21°C (70°F)
ENE 7mph
Sun 24 Jan 22°C (72°F)
(9kmh)
Mon 25 Jan 22°C (72°F)
NNW 7mph
Tue 26 Jan 24°C (75°F)
Wed 27 Jan 24°C (75°F)
S 11mph
W 16mph
WNW 14mph
WSW 11mph
W 9mph
Mon 1 Feb 23°C (73°F)
Tue 2 Feb 24°C (75°F)
Wed 3 Feb 22°C (72°F)
Thu 4 Feb 22°C (72°F)
Fri 5 Feb 19°C (66°F)
Sat 6 Feb 18°C (64°F)
Sun 7 Feb 18°C (64°F)
Night 9°C
Wed 10 Feb 20°C (68°F)
Thu 11 Feb 22°C (72°F)
Fri 12 Feb 22°C (72°F)
Sat 13 Feb 22°C (72°F)
Sun 14 Feb 22°C (72°F)
Sharm El Sheikh Hourly Weather Forecast
6:00 14°C (57°F)
12:00 18°C (64°F)
Sharm El Sheikh IMAGES
Sharm El Sheikh Weather Now
Sharm El Sheikh february averages
Egypt Weather
Sharm El Sheikh Annual Averages


A 2 bedroom home in Baan Tai on Koh Samui is offered for sale here at Doctor Property. Baan Tai is located in the north of the beautiful island Koh Samui. Thailand's third largest island lies on the eastern side in the Gulf of Thailand. Here you will find a year-round tropical climate. Every year more than 3 million tourists from all over the world travel to Koh Samui and enjoy the beautiful nature and the beautiful beaches. Baan Tai also has a beautiful public beach and is only 25 minutes from the airport.
This house has 2 bedrooms, a bathroom and is fully furnished. Overall, the plot is 160 m2. The living space is about 80 m2. Due to the low purchase price, this offer is very interesting. Renting these houses to tourists is very common and popular in this area. We look forward to your contact and a joint visit.
The purchase price is only 2,800,000 THB.


Bins are a necessity in an educational setting, as they can be used to teach children about the importance of recycling and clearing up after themselves, as well as a method to keep the premises litter free. The lunar 95 litre bins from Slingsby are an excellent addition to school premises, in vibrant colours and interesting designs. They have an open top design, making it easy for users to deposit debris into the bins and they are manufactured from strong polyethylene, ensuring that they are durable products. These bins can be used both indoors and outdoors and they have a capacity of 95 litres, making them ideal to place in areas where there it is likely there will be a large amount of waste. They are available in four colours; green, light blue, red or yellow and there are two designs; a smiley face logo, which would be best suited to primary/infant schools or a tidy man logo, which is ideal for middle/high schools. Our lunar 95 litre bins are a great addition to any education environment, offering an easy place for students to throw away their rubbish and they come with FREE UK Delivery.


Def Leppard played a 2016 World Tour show last night in Toledo, OH and here are the setlist statistics.
The show took place at Huntington Center with 17 full songs played.
View all the stats below after 57 shows.
Visit the Toledo show page to view the latest setlist.
The next show takes place in Cedar Rapids, IA on 10th October.


text:
package com.capitalone.dashboard.status;

public enum BuildAuditStatus{
    BUILD_JOB_IS_NON_PROD,
    BUILD_JOB_CONFIGURATION_REVIEW_FAIL,
    BUILD_JOB_CONFIGURATION_REVIEW_PASS,
    BUILD_JOB_CONFIGURATION_NO_CHANGE,
    COLLECTOR_ITEM_ERROR, BUILD_MATCHES_REPO, BUILD_REPO_MISMATCH, BUILD_AUTHOR_EQ_REPO_AUTHOR, BUILD_AUTHOR_NE_REPO_AUTHOR, NO_BUILD_FOUND, BUILD_JOB_IS_PROD
}


text:
The incandescent light bulb's demise once gave ample fodder for GOP stump speeches.
Lights out for the light bulb battle?
By ANDREW RESTUCCIA
So much for the light bulb wars.
The years-long political grudge match over Thomas Edison's legacy ended with a whimper on New Year's Day, when federal energy-efficiency rules barred the manufacture and import of traditional 40- and 60-watt incandescent bulbs. And this time, conservatives reacted with little more than a shrug.
No tea party protests took place outside Home Depots, demanding a return to the bulb that served as a staple in American homes for more than a century. Most Republican lawmakers ignored the issue altogether — a contrast to recent years in which the plight of the light bulb was an applause line in GOP stump speeches and the subject of repeated rescue attempts in the House.
( Also on POLITICO: Full energy and environment policy coverage)
Republicans may not be able to bring back the incandescents, but many still hope voters will know which party to blame.
"I think in general that Rs have decided that, with the record clear as to their opposition, they will let this Administration roll out these and other regulations directly affecting consumers, like Obama care, and see how consumers feel about them," Linda Stuntz, a former deputy energy secretary from the George H.W. Bush administration, said in an email Friday. "If consumers are unhappy, the identity of those responsible will be clear."
But others say voters have moved on — as has the light bulb industry. Prices have fallen for compact fluorescent, LED and halogen bulbs, the more efficient alternatives that the industry has churned out in growing numbers since then-President George W. Bush signed the 2007 law creating the new standards.
( Also on POLITICO: Obamacare overshadows cap and trade)
"There's a couple politicians for whom this is a big deal and may remain a big deal, but I think in the grand scheme of things, for consumers it's sort of a nonissue," said Elizabeth Tate, director of government relations at the Alliance to Save Energy. "With so many other big things happening, it seems like a waste of time. It's a small issue when you've got budget fights."
Another factor: Most of the companies affected by the standards don't oppose them.
"We've seen the writing on the wall for a good long time," said Paul Molitor, an assistant vice president at the National Electrical Manufacturers Association, which represents dozens of light bulb manufacturers. "The law is very clearly written, and they've been anticipating it and their factories have been retooled to accommodate it."
Besides, Molitor said, one federal light bulb standard is better than a patchwork of state rules.
( PHOTOS: Climate skeptics in Congress)
All this is a far cry from the days when even a minor reference to the light bulb "ban" was catnip for conservative voters.
During the past Republican presidential primary, nearly every one of Michele Bachmann's campaign speeches included a dig at President Barack Obama over the standards. "President Bachmann will allow you to buy any light bulb you want," she said at the Southern Republican Leadership Conference in 2011, repeating a line in her stump speech.
In the House, Republicans approved several measures to block enforcement or defund the rules. (A spokeswoman for the House Energy and Commerce Committee said Friday that GOP lawmakers will keep trying.) Conservative broadcasters like Rush Limbaugh and Glenn Beck regularly pound the same theme, and Beck said in August that he would fire employees that buy compact fluorescent bulbs.
Tea party favorite Sen. Rand Paul (R-Ky.) has held up the light bulb rules as a prime example of Big Government run amok.
( Also on POLITICO: 10 must-watch House races for 2014)
"Lightbulbs, refrigerators, toilets, you name it. You can't go around your house without being told what to buy," Paul said in 2011 while chastising an Energy Department higher-up. "You restrict my purchases. You don't care about my choices. You don't care about the consumer."
In turn, Obama has openly mocked conservatives' obsession with the bulb rules. "We've actually been criticized that it's a socialist plot to restrict your freedom for us to encourage energy-efficient light bulbs. I never understood that," the president said in August.
The 2007 energy law didn't ban any type of light bulb. Instead, it requires that new bulbs use about 30 percent less energy than traditional incandescents.
Under those standards, manufacturing and imports of traditional 100-watt and 75-watt incandescent bulbs were phased out in 2012 and 2013, respectively. But 60- and 40-watt bulbs, which were phased out under the new standards as of Wednesday, make up the majority of incandescents in the United States.
Sales of the old bulbs are still allowed as long as supplies last, which has prompted some news reports about hoarding.
Opponents of the standards have raised a number of concerns, including the fact that efficient bulbs are more expensive — for example, one 40-watt incandescent runs around $1 or $2 and the equivalent compact fluorescent starts around $4 or $5. But prices vary, and some higher-end efficient bulbs can cost more than $100.
On the other hand, the new bulbs last much longer and waste much less of their energy as heat. For example, it costs about $4.80 per year for the average consumer to run a traditional incandescent light bulb. But it costs on average about $1 per year for an LED and $1.20 per year for a compact fluorescent, according to the Energy Department.
While the more efficient bulbs tend to be more pricey at the point of sale, in general they save consumers money in the long term.
"You're going to be saving money in two ways," Tate said. "First, you're not going to be replacing bulbs like you were before. Second, they use less energy, so that's less money you're going to be spending on your electric bill."
Still, some Republicans aren't convinced the issue is gone for good.
"I'm not sure voters are aware of it. But they will be soon, and it will become emblematic (especially among the Right) of government gone crazy," GOP energy strategist Mike McKenna said in an email. "I mean, these people can't win wars, solve the drug problem, balance a budget or even get a website to work. But damn it, they still feel confident enough in their own judgment and wisdom to tell citizens what kind of light bulbs they can use. The speech pretty much writes itself."


The RN MDS Coordinator assists the Administrative Director of Nursing Services with ensuring that documentation in the center meets Federal, State, and Certification guidelines. The MDS RN coordinates the RAI process assuring the timeliness, and completeness of the MDS, CAAs, and Interdisciplinary Care Plan.
Graduate of an approved Registered Nurse program and RN licensed in the state of practice required.
Minimum of 2 years of nursing experience in a Skilled Nursing Facility preferred. Excellent knowledge of Case-Mix, the Federal Medicare PPS process, and Medicaid reimbursement, as required. Thorough understanding of the Quality Indicator process. Knowledge of the OBRA regulations and Minimum Data Set. Knowledge of the care planning process.


text:
<?xml version="1.0" encoding="utf-8"?>
<!-- Created by ModBuddy on 8/22/2013 8:06:59 PM -->
<GameData>
	<!-- Adding a new CityState entry. -->
	<MinorCivilizations>
		<Row>
			<Type>MINOR_CIV_PHOENICIA</Type>
			<Description>TXT_KEY_CITYSTATE_PHOENICIA</Description>
			<ShortDescription>TXT_KEY_CITYSTATE_PHOENICIA</ShortDescription>
			<Adjective>TXT_KEY_CITYSTATE_PHOENICIA_ADJ</Adjective>
			<Civilopedia>TXT_KEY_CITYSTATE_PHOENICIA_PEDIA</Civilopedia>
			<DefaultPlayerColor>PLAYERCOLOR_MINOR_LIGHT_ORANGE</DefaultPlayerColor>
			<ArtDefineTag>ART_DEF_CIVILIZATION_MINOR</ArtDefineTag>
			<ArtStyleType>ARTSTYLE_GRECO_ROMAN</ArtStyleType>
			<ArtStyleSuffix>_MED</ArtStyleSuffix>
			<ArtStylePrefix>MEDITERRANEAN</ArtStylePrefix>
			<MinorCivTrait>MINOR_TRAIT_INTELLECTUAL</MinorCivTrait>
		</Row>
	</MinorCivilizations>
	<MinorCivilization_CityNames>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<CityName>TXT_KEY_CITYSTATE_PHOENICIA</CityName>
		</Row>
	</MinorCivilization_CityNames>
	<MinorCivilization_Flavors>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_EXPANSION</FlavorType>
			<Flavor>9</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_CITY_DEFENSE</FlavorType>
			<Flavor>6</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_DEFENSE</FlavorType>
			<Flavor>7</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_WONDER</FlavorType>
			<Flavor>6</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_HAPPINESS</FlavorType>
			<Flavor>7</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_CULTURE</FlavorType>
			<Flavor>9</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_INFRASTRUCTURE</FlavorType>
			<Flavor>8</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_PRODUCTION</FlavorType>
			<Flavor>8</Flavor>
		</Row>
		<Row>
			<MinorCivType>MINOR_CIV_PHOENICIA</MinorCivType>
			<FlavorType>FLAVOR_GREAT_PEOPLE</FlavorType>
			<Flavor>6</Flavor>
		</Row>
	</MinorCivilization_Flavors>
	<Language_en_US>
		<!--
		<Row Tag="TXT_KEY_CITYSTATE_PHOENICIA">
			<Text>Finland</Text>
		</Row>
		-->
		<Row Tag="TXT_KEY_CITYSTATE_PHOENICIA_ADJ">
			<Text>Phoenician</Text>
		</Row>
		<Row Tag="TXT_KEY_CITYSTATE_PHOENICIA_PEDIA">
			<Text>No entry available! Sorry.</Text>
		</Row>
	</Language_en_US>
</GameData>


text:
Eaton is a village and civil parish in the unitary authority of Cheshire East and the ceremonial county of Cheshire, England. According to the 2001 census, the population of the civil parish was 289. Congleton is the nearest large town.Buses serve the Village Monday to Saturday

See also

Listed buildings in Eaton, Cheshire East
Christ Church, Eaton

References

External links

Villages in Cheshire
Civil parishes in Cheshire