Before anyone gets up in my grill about this - this blog is just my opinion, backed up by a few logical reasons. Almost 2 years ago, I succumbed to buying YAG (Yet Another Gadget).
Let's just say that after a while, I realised that it just wasn't for me. I'll also state, right now, that I'm no fitness guru. I like to stay fit, exercise, stay kinda healthy, but I'm not a nut about it.
Now gadgets - there, I'm a nut. So, the fitbit. OK, thanks for telling me I slept well. It's taken me over 30 years to establish how well I sleep, but now I have a device that tells me just that. I'd prefer a gadget that tells me when I'm susceptible, getting sick and how to get batter faster.
Honestly, it's lame. How I managed, In 1/2 minutes, to climb 4 flights of stairs and gather a whole bunch of steps while on the bed, tying my shoe laces, indicates a flaw in the design. It uses a meter to detect motion in a series of directions. It's a smart concept, I will say, but flawed.
I've tried a whole bunch of fitness gadgets. Heart rate monitors, foot pods, Fitbit, Pedometers, GPS, Phone apps and I can tell you this: it's really pretty simple. you need something that can measure your heart rate accurately and uses a decent set of algorithms to determine your exertion. That's the ONLY way to tell if you're actually serious about it.


text:
The Skinny on Lean Publishing
Lean Startup Co. Faculty member Hisham Ibrahim and Leanpub Founder & CEO Peter Armstrong discuss the parallels between books and startups, and how going Lean can help authors overcome the psychological barriers to writing in order to create an MVP, publish early, iterate based on feedback from early readers (adopters), and ultimately, publish a successful book.
Don't miss our companion blog below where we further explore how authors can more easily build community, test ideas in real time, and release books that readers want to support by putting Lean Startup practices into play.
"You can test the market for a book before you've even written a word." [email protected] Click To Tweet
If you'd like to read the full transcript of Hisham Ibrahim's conversation with Peter Armstrong, you may download it.
Using Lean Publishing to Release Books Your Customers Want
When we think about book publishing, we often imagine the slow-moving processes of the past. An author toils away on a project for years, working off an idea pitched to an editor, hoping that there's an audience invested enough in its premise that they purchase it by the time the writing's done.
Of course, there are more innovative ways to approach publishing, methods Eric Ries and other authors have been publicly testing, thanks in part to such platforms as Leanpub and Kickstarter. By putting Lean Startup practices into play, authors can more easily build community, test ideas in real time, and release books that readers want to support.
We focused on the practicalities of Lean Publishing in a recent webcast conversation between Lean Startup Company Faculty member Hisham Ibrahim and the co-founder and CEO of Leanpub, Peter Armstrong. Here is the quick lowdown on Lean Publishing, below are the highlights of Peter's tips and tactics.
It's an Excellent Time to Publish Lean
As CEO of an eBook company, Peter says our current era offers amazing publishing opportunities. "Books can go from having commoditized margins with returns, shipping, [and] physical stores to having software margins with no marginal costs, [and] millions of customers with computers, billions with phones." He says we're shifting away from industry models burdened with barriers to entry and toward using data and customer feedback to lead the way.
Making Lean Startup Part of Your Book Publishing Practice
At its core, Lean Publishing is about figuring out if there's a market for your book, says Peter, and discovering what clicks with your audience. You're getting your ideas in front of people so you can iterate based on what you're learning.
"You can test the market for the book before you've even written a word," he says. "Put up an attractive landing page and see if people sign up." By using Lean Startup you're not just revising for your editor, you're out there in the public developing the arc of your product with the people most eager to consume it. "You want to measure, is there even a market, or can I reach that market?" Peter says.
Both Leanpub and Kickstarter offer potential customers a synopsis of what you'd like to publish, and you can test directly whether people are willing to pay for that project. "You get an idea roughly of your total addressable market or what portion of it you can reach," Peter says.
Once you have an understanding of your audience, he says, you can start writing—and then ship quickly, as you would any other MVP. "You should ship your first version of the book for your MVP when you're kinda embarrassed by it still," he says. "I recommend you ship when you think you could…save an extra one or two hours of time." He says typically a one to three chapter book offers an author the opportunity to save time by iterating in real time. You can show a book of that length to both a novice and an expert in the field and get their feedback, and then publish often and gather more feedback.
"Keep releasing, keep iterating, getting feedback from readers, find out what works, what doesn't, produce new versions," Peter says. "This process can go as long as you need it to. Typically, we expect that when people use Leanpub, for example, they iterate in public for months."
Sales are Just one Marker of Success, Engagement is Another
Obviously money helps define success when it comes to publishing, but Peter says engagement is another key factor to watch. "Some authors have set up their own private forums like mailing lists," he says. "Lots of people engage with them on social media, Twitter, email, so as an author, you can tell when your publishing in-progress is disconnecting with people or not—first from the sales, [then] qualitatively from the type of engagements from your reader."
Don't Worry About Being an Expert at the Outset: Iterate as You Learn
Peter says generally the first step towards Lean publishing is writing a blog. But from there, his advice shifts into what not to do. Don't worry that you're not an expert just yet. "Lots of people who have written successful books on Leanpub aren't world experts in their field," he says. Instead, focus on whether you have something you're passionate about sharing with people.
Once you start writing, he adds, publish sooner rather than later. "If wondering if you should publish or not, chances are you should have published," he says, adding that the importance of building community as you go can't be overstated.
This is especially true when it comes to niche topics. Books that wouldn't make it to market with the big publishers of the past do really well on Leanpub, Peter says, because they reach and build the communities most interested in these subjects as they're being written.
Don't Spend Time Worrying About People Stealing Your Ideas
If you release nascent ideas into the world, there's always a chance that someone else will notice and run with them. Peter says that it's no different with publishing than it is with startups. Success doesn't come from strong concepts alone—you need a community listening to what you're saying. "If the only thing that helps you is your initial idea and you're not going to execute better, and you're not gonna build a community around your work, who cares?" he says. "The insecurity that nobody cares is the bigger fear…. what if no one wants to steal your idea?"
He adds that the Internet has a good memory, so getting those rough ideas out there early, iterating upon them, and building a community offers some insurance that you'll be the pioneer in the public's eyes, and those copycats will be the derivative ones.
Thank you to Jennifer Maerz for contributing this piece. Give us a shout out on Twitter @leanstartup and let us know what you thought of our non-traditional Lean Startup piece.
Lean Startup Co. Faculty member Hisham Ibrahim and Leanpub Founder & CEO Peter Armstrong discuss the parallels between books and startups, and how going Lean can help authors overcome the psychological barriers to writing in…
Five Ways to Innovate Inside Government Agencies
During a recent Lean Startup Conference, Kara DeFrias moderated a panel with Marina Martin, Vivian Graubard, Eduardo Ortiz, and Tiffani Ashley Bell on what the private sector can learn from government. Most entrepreneurs may never…
Innovate Better By Listening To Your Customers
We recently hosted a webcast conversation between Sonali and Elliot focused on innovation and why it's so important to speak to your customers early and often. Don't have time for the full webcast now? Catch…

redpajama_set_name: RedPajamaCommonCrawl


Two words: Overnight shipping. You can get these beauties just in time for NYE. As for me, I'll be wearing these bad boys and sipping champs with the pups. Taking it easy this year and wouldn't want it any other way.


text:
Home Rare Journey Resources
Every rare journey is unique, but there are many experiences that people may have in common. The Rare Journey graphic represents some of those commonalities within the different potential phases or stages of life with a rare condition.
Finding a diagnosis can be challenging. It can take several years for people living with a rare condition. If you feel like something is wrong but don't know where to start, or you've been through several doctors and don't know what to do next, these resources may be able to help guide you on the path to answers and care.
View Searching for a Diagnosis Resources
You've gotten a rare disease diagnosis. Now what? There is so much to learn and do that it will be overwhelming. Take your time and prioritize your needs. Try to remember that there is support out there and a community of people who are ready to help – because they've been where you are now. Here are links to several resources that may help you navigate this complex and uncertain time.
View Understanding Diagnosis Resources
It's likely that your day-to-day routines will change after a rare diagnosis, and how you manage the condition over time may also change. Symptoms can evolve, new standards of care may appear, social environments fluctuate, and more. They say that the only constant is change and daily living with a rare disease includes coping and caring for your whole self – physically, mentally, emotionally, and socially.
View Managing Daily Life Resources
Knowing where to go for information about the condition that impacts you or your family can be daunting or confusing. It's difficult to know what a reputable and credible source may be. Over time, you will find yourself becoming an expert, even knowing more than many healthcare providers. These resources can help guide you on where you can look to get educated and find support and advice.
View Getting Educated Resources
As someone living with a rare disease, it's important to "own" it. You are your best advocate, and you can surround yourself with people who will support you throughout your journey. You may not have expected this journey, but these resources may be able to help you take ownership of it and live your best life.
View Taking Ownership Resources
Life is full of transitions. Growing up, going to school, starting a family, changing doctors. Almost everyone experiences these changes, but going through these while living with a complex illness may present additional or unique challenges. These resources will help you prepare and navigate.
View Transitioning Care Resources
The future may be uncertain, but it can still be filled with hope. There are ways you can plan for your individual future and contribute to a better and brighter future for the whole rare community – including those yet to come. Learn about opportunities to plan, participate, and make an impact for future generations.
View Preparing to Advocate Resources
These resources are intended for U.S. audiences only. Have a topic that you'd like us to address in your country? Contact us.
Share Your Rare Journey
Traveling with a Disability
Communicating with Healthcare Providers
Advocate with and for Your Community
Choosing to tell your story is a powerful way to advocate for yourself. Use this checklist to help you connect, educate, and inspire others to act.
Download Share Your Rare Journey
Health insurance can be confusing. This resource can help you understand your choices and find assistance.
Download Understanding Health Insurance
Traveling with a complex health condition can be challenging, but it's not impossible. With research, planning, and patience, travel can be rewarding! Use these tips to help you prepare for your next adventure.
Download Traveling with a Disability
Get the most from your visits with healthcare providers by following these simple guidelines.
Download Communicating with Healthcare Providers
Get started with confidence! Advocacy starts with the belief that you can make a difference.
Download Your Guide to Getting Started in Community Advocacy
COVID-19 Resources & Information
The ever-changing nature of the COVID-19 pandemic can lead to feelings of anxiety and uncertainty, especially for those living with rare and chronic conditions. We've compiled the below resources to help you manage and stay safe:
EveryLife Foundation for Rare Diseases
National Organization for Rare Disorders
Global Genes
National Alliance for Caregiving
Rare Diseases Clinical Research Network
Child Neurology Foundation
In the company of
defenders, disruptors, and the decidedly different.
Ultragenyx works side by side with organizations that provide educational resources and support for those affected by rare disorders. The advocacy groups listed on this page have information that is helpful across many diseases. They are often called "umbrella" organizations. For disease-specific advocacy organizations or information, check out the conditions we study.
Find a Patient Advocacy Group
Have a suggestion, know of a helpful resource that should be listed, or think we should add a topic? Contact us! Email [email protected].


text:
The Lancet (angleško: »skalpel«) je britanska znanstvena revija za področje splošne medicine, ki jo izdaja založniško podjetje Elsevier. Uredništva ima v Londonu, New Yorku in Pekingu.

Revija izhaja tedensko in objavlja izvirne znanstvene članke, pregledne članke, uvodnike, recenzije knjig, razno korespondenco, novice s širšega področja medicine ter poročila o primerih.

Velja za eno najvplivnejših in najprestižnejših medicinskih revij na svetu. Njen faktor vpliva je leta 2021 znašal 79,3, s čimer je bila v kategoriji splošne in interne medicine druga najbolj citirana revija (za The New England Journal of Medicine). Njen trenutni glavni urednik je Richard Horton, pod vodstvom katerega se revija v uvodnikih in drugih člankih pogosto izreka tudi o političnih temah (bolj ali manj povezanih s področjem javnega zdravja na globalni ravni), kar po mnenju nekaterih komentatorjev ogroža zaupanje v objektivno znanost.

Zgodovina
Revijo je leta 1823 ustanovil kirurg Thomas Wakley, da bi poročal o kliničnih predavanjih v londonskih bolnišnicah in vidnejših zdravniških primerih svojega časa. Poimenoval jo je po skalpelu, enemu ključnih kirurških pripomočkov. Wakley je veljal za radikalnega reformatorja, ki se je boril za profesionalizacijo in regulacijo zdravniškega poklica v Združenem kraljestvu. V uvodnikih je zato pogosto napadal šarlatane, pa tudi zdravniško elito, ki se je upirala državni regulaciji področja. The Lancet je kmalu prerasel v vplivno publikacijo in je občutno vplival na zdravniške reforme v Združenem kraljestvu.

V The Lancet je bilo prvič objavljenih nekaj prelomnih odkritij v medicini, kot so anestetične lastnosti kloroforma (James Young Simpson, 1847), Listerjeva pobuda za antiseptične postopke v kirurgiji (1867), uporaba ultrazvočnega slikanja v porodništvu (Ian Donald s sod., 1958), Glasgowska lestvica kome (Graham Teasdale in Bryan J. Jennett, 1974) idr. Od bolj kontroverznih je znana zlasti študija Andrewa Wakefielda, objavljena leta 1998, ki je povezala cepivo OMR s pojavom avtizma pri otrocih in je pomembno vplivala na nasprotovanje cepljenju v razvitem svetu. Kmalu po objavi je bila študija deležna ostrih kritik s strokovnega in etičnega vidika, a je uredništvo kljub odkritemu navzkrižju interesov sprva branilo objavo zaradi zanimanja javnosti. Šele 12 let kasneje, po množici drugih študij, ki so ovrgle vzročno povezavo med cepljenjem in boleznijo, ter drugih razkritjih o neetičnosti Wakefieldove študije, je The Lancet članek umaknil.

Leta 1921 je izdajanje prevzelo založniško podjetje Hodder & Stoughton, od katerega ga je leta 1991 odkupila nizozemska korporacija Reed Elsevier.

Sklici

Zunanje povezave

Britanske revije
Medicinska literatura
Ustanovitve leta 1823
Znanstvene revije

redpajama_set_name: RedPajamaWikipedia


text:
Q: Stuck in infinite fgets loop I'm trying to get a integer input, and I tried the most elementary method I could find. However, whenever something isn't a integer, it gets stuck in a infinite loop. I believe it's caused by the fgets funcion. I tried a few solutions I found on this site, but none worked. The code is as follows
int getint()
{
    int number;
    char input[4];

    fgets(input, 4, stdin);
    while ( atoi(input) < 0 || ( strcmp(input, "0") != 0 && atoi(input) == 0 ) )
        printf("Insert a non negative number: ");
        fgets(input, 4, stdin);
    number = atoi(input);
    printf("%d\n", number);

    return number;
}

A: If there are more than one statements that you want to write in a loop or if statement, then you must use braces {} to define which statements come in the loop.
In your code, only the printf("Insert a non negative number: "); statement is in the loop, and nothing is changing the input's value in the loop, so if the loop's condition is true, it will always remain true.
Change it to:
while ( atoi(input) < 0 || ( strcmp(input, "0") != 0 && atoi(input) == 0 ) )
{
    printf("Insert a non negative number: ");
    fgets(input, 4, stdin);
}

redpajama_set_name: RedPajamaStackExchange


The silence of heaven. The dark night of the soul. The desert place. We hurt. We cry out to God. But we wonder if He has forgotten us. We believe He is sovereign, yet it seems as if He is no longer looking at us in our circumstances. We pray. We persist like the widow in Jesus' story (Luke 18:1-9), waiting for the Lord to answer, trusting He hears us as His word promises (1 John 5:14-15). But we receive no reply. No indication we have been heard. We wonder how long.
A short time ago our new community minister at Oak Hills Church talked to some of the community leaders and in the midst of his discussion he made a simple comment about growth occurring in the trenches. His comment resonated with me because, recently, when asking the Lord what I had to write about, what I could pass on to others, He reminded me of the trenches. But what about the trenches? I thought about the many uplifting stories I hear and what sometimes discourages me about them. Books, stories and testimonies often highlight the successes but gloss over the trenches. We like to hear about the mountain top experiences and the miraculous answer to prayers, except when it seems that, for us, heaven is silent, and God has looked the other way.
Throughout of my naval career (and subsequently, my christain adult life) I often prayed for women encouragers. Don't get me wrong, the Lord brought some amazing women into my life over the years. But I longed for the encouragers, the ones who speak life into our lives, who have just the right word of wisdom or insight, who are bold enough to point out when we are in error, who put their arms around us and tell us we are loved with an infinite love and that we will make it. I prayed. I prayed some more. But heaven seemed silent.
Those years seemed like a long walk in the trenches. But, looking back, I realize, might it be, He allowed me time in the trenches, because in the trenches is when we really grow.
It wasn't until the past few years that the floodgates of heaven finally opened and those prayers thought to have fallen on silent ears have poured out with incredible answers. I stand in awe. I am amazed. I am humbled. And I am thankful beyond words. Had my years been filled with these women, I might have thought it commonplace, just part of everyone's christian experience. But sadly, we know it to not often be the case.. And knowing that, I cherish it all the more.
God had not forgotten me. He was not looking the other way. He was watching me suffer and grow. He was teaching me how to lean on Him, to be encouraged by His Spirit and not depend on the words of men and women. And like He promises, I'm not to grow weary and give up doing what is good. When I don't lose heart in the trenches, when I trust in Him, I will reap the harvest in His perfect time.
Father, when it seems you have forgotten me and looked the other way, remind me of your great and many promises. When I walk in the desert place, when the night is dark, and heaven is silent, strengthen my heart for what you are teaching me. Thank you, Father, that you love me enough to give me time and room to grow before reaching the mountain top.


text:
Jimmy Fallon's Donald Trump Thinks 'First Is the Worst, Second Is the Best'
Jimmy Fallon's Donald Trump returns to The Tonight Show to justify his failure in Iowa.
Matt Wilstein
The real Donald Trump may have been uncharacteristically gracious in his Iowa concession speech this week, but when Jimmy Fallon brought back his impression of the candidate last night he was emphasizing the benefits of a second place finish.
"The people of Iowa have wisely named me the winner and champion of second place," he said, using the old childhood saying, "First is the worst, second is the best, third is the one with the hairy chest," to explain away his loss.
In Trump's estimation, "two is bigger than one" and "one plus one is two" so, basically, he "won twice."
"From now on, when you think of Donald Trump, I want you to think 'huge number two,'" he said. Easy joke? Sure. But what else is new for the man who is still expected to win in New Hampshire?


text:
Bush Administration Slammed for Poor Health Measure at Ground Zero
Xinhua, August 18, 2004
NEW YORK, Aug. 18 (Xinhuanet) -- An environmental group Wednesday criticized the Bush administration for failing to warn people of the health risks of breathing toxic smoke and dust at ground zero.
In a report on the environmental and health impacts of the collapse of the World Trade Center twin towers, the environmental group Sierra Club accused the administration of showing "reckless disregard" for public health.
"The federal government should have a duty to protect the public from the aftermath of an attack such as this," said SuzanneMattei, the report's author.
The report said that hundreds of people were sickened because of mistakes made by the government during the recovery and cleanup effort following the Sept. 11 terrorist attack.
According to the report, the Environmental Protection Agency (EPA) failed at least a dozen times to change its safety assurances about the air quality at ground zero, even after it became clear that people were becoming sick, and in some cases, did not even check for toxic hazards.
Mattei accused the Bush administration of ignoring the potential health risks because of political expediency. "They wanted to reopen the stock exchange in Lower Manhattan as quickly as possible and I think they wanted to put forth the image that everything was OK," she said.
The report said the government should have issued a warning immediately after the attacks about the hazards of inhaling the air there. Consequently, many rescue and recovery workers at the disaster site did not wear respirator masks because of conflicting assurances about air quality, the report said.
The group also cited a little known study in the July 2002 Journal of Occupational and Environmental Medicine that compared the health of federal employees working five blocks north of ground zero to their colleagues in Dallas.
The study found that employees at the Department of Health and Human Services who were indirectly affected by the trade center collapse "were more than likely to report constitutional symptoms"such as eye, nose and throat irritation and headache, than those in Dallas.
The report said the Bush administration "has learned nothing from the illnesses and hardships suffered by the ground zero community. Rather, it plans to perpetuate them in any future national disaster anywhere else in the United States."
The group urged the government to continue to vigorously clean up businesses and residences around the trade center site, fund long-term medical monitoring of people exposed to smoke and dust at ground zero and develop a national plan to inform the public of health risks following a terrorist attack.
Copyright ©2003 Xinhua News Agency. All rights reserved.
http//news.xinhuanet.com/english/2004-08/19/content_1819475.htm


Inefficient applicant tracking software solutions are hindering the hiring of the right staff at a time when industry is demanding ultimate efficiency in recruiting, claims a recruitment outsourcing expert.
Amanda Marques, Managing Director of recruitment outsourcers PPS, said "One size fits all" software packages need to be ditched to ensure efficient recruiting of top calibre staff.
This comes at a time when the British Retail Consortium are reporting an increase in store openings and employment figures in comparison to the same period last year. The increase is equivalent to more than 12,000 jobs.
She said many software solutions are based on core models, which makes assumptions about each company's recruitment process.
She added that lack of staff awareness of software features was an issue too.
"We can all be wowed at wonderful features that are shown at presentations, but often staff never use these features meaning more often than not only a small fraction of the software's capabilities are being used. " she added.
She said that constructing packages with relevant modules, as her company and other outsourcing specialists now do, was now being seen as a step worth taking in the current climate.


Pure trash Kent. You had Sincs on for the handball.
Another miss when we need a goal.
FFS Kent, couldn't even kick a point.
Our forwards have been useless apart from Long.
Man this is tense. It's anybody's match now - Saints need to make this final quarter performance tell on the scoreboard.
Kent should maybe maybe visit his namesake and piss off.
If you look up "Strong in the contest" in Richo's Big Book Of Words - there will be a picture of Lonie in it.


There are many places of interest and colonial tourist attractions to be found around the Plaza de Armas in Iquitos city centre and lining the nearby riverfront, which retreats somewhat during the summer months. Close by, a walk along the Malecon Tarapaca and around the Belen Quarter of Iquitos will reveal a neighbourhood quite unlike any other that you will have ever seen before, while family friendly tourist attractions include the Amazon Animal Orphanage, the Pilpintuwasi Butterfly Farm and the Quistococha Lagoon.
With so many places of interest and quality Amazonian attractions spread all around the Iquitos area, it makes a lot of sense to make use of the plentiful tour operators, who will help you to make the most of your time spent exploring Peru's northern rainforest.
Belen is best described as a floating shanty town, with rustic houses standing on wooden stilts or rafts, with the entire area being flooded by the Amazon River for much of the year, particularly during the rainy season. Around 7,000 people currently call this part of Iquitos their home, with traditional canoes often floating between the huts, selling their very own Amazonian jungle produce. Tourists will find that the unusual attractions within the Belen Quarter are best viewed early in the morning, at around 07:00, when market traders from neighbouring villages arrive. A great way to tour the area is by guided canoe, and these are available for hire at Belen's port (Puerto Itaya).
A variety of day trips, jungle packages and cruises on the Amazon River are on offer, with tourists favouring destinations such as the Allpahuayo Mishana National Reserve, the Pacaya Samiria National Reserve (see below), and also the Tamshiyacu Tahuayo Reserve. Do be sure to only use recommended tour operators, and if possible, use one of the indigenous residents as your personal Amazon tour guide.
The Malecon Tarapaca is a very special trail alongside the south-easterly river banks and was created during the affluent period of the rubber boom. Offering a peaceful place to stroll and some very pleasant panoramas, the Malecon Tarapaca stretches from just below the Plaza de Armas, leading right up to the Belen Market, running parallel to the Prospero.
Malecon Maldonado offers a very scenic riverside walk on the eastern side of central Iquitos and serves as the city's main promenade, leading on from the adjoining Malecon Tarapaca and passing many attractions along the way, such as the Fitzcarraldo Restaurant. Tourists may know this pedestrian only trail better as the Maldonado City Walk and will often find lively street entertainers performing to small crowds, usually juggling, singing, playing panpipes or dancing with giant snakes, all of which creates something of a carnival atmosphere.
Highly suitable for all ages, the Amazon Animal Orphanage is a recommended attraction for many different reasons, and conveniently close to Iquitos, residing in nearby Padre Cocha, alongside the Nanay River. Visitors will be able to see a small collection of native wildlife, with each of the animals having been rescued after losing their mothers. Tapirs, anteaters, red uakaris and even a capuchin monkey can all be observed close up in their spacious surroundings. Adjoining the Amazon Animal Orphanage is the ever-popular Pilpintuwasi Butterfly Farm, which serves as a breeding centre for some extraordinarily beautiful Amazonian butterflies. Around 40 different species of butterfly are kept in a large enclosure where visitors are able to walk freely, often being followed by wild monkeys on the roof. From Iquitos, the simplest and most scenic way for tourists to reach these attractions is to hire a motor boat from the Bella Vista Port.
The Quistococha Lagoon is really a must-see and lies on the outskirts of the city, some 7 km / 4 miles from Iquitos proper. Tourists flock here during the Peruvian summer months (December to March), sunbathing on the golden sands of its artificial beach, before cooling down in the adjoining tranquil waters of the lake itself. Families will particularly enjoy the animal attractions at the Quistococha Zoological Park, which has been open since 1979 and covers around 900 acres / 360 hectares in total. Visitors to the zoo will find many creatures indigenous to Peru and the Amazon Basin, such as monkeys, snakes, alligators, parrots and tapirs, together with a very well-maintained botanical garden. If you don't have time to make the zoo, you may well be able to spot the wild monkeys living in the trees around the Quistococha Lagoon.


Jacket in cotton with wide collar and adjustable cuffs. Front fastening with buttons and double cursor hidden zip. Waist with adjustable drawstring for a personalised fit. Two breast pockets on the chest and two large bag pockets with flap and buttons. Aspesi logo in velcro on the shoulder.


text:
The PDZ domain is a common structural domain of 80-90 amino-acids found in the signaling proteins of bacteria, yeast, plants, viruses and animals. Proteins containing PDZ domains play a key role in anchoring receptor proteins in the membrane to cytoskeletal components. Proteins with these domains help hold together and organize signaling complexes at cellular membranes. These domains play a key role in the formation and function of signal transduction complexes. PDZ domains also play a highly significant role in the anchoring of cell surface receptors (such as Cftr and FZD7) to the actin cytoskeleton  via mediators like NHERF and ezrin.

PDZ is an initialism combining the first letters of the first three proteins discovered to share the domain — post synaptic density protein (PSD95), Drosophila disc large tumor suppressor (Dlg1), and zonula occludens-1 protein (zo-1). PDZ domains have previously been referred to as DHR (Dlg homologous region) or GLGF (glycine-leucine-glycine-phenylalanine) domains.

In general PDZ domains bind to a short region of the C-terminus of other specific proteins. These short regions bind to the PDZ domain by beta sheet augmentation. This means that the beta sheet in the PDZ domain is extended by the addition of a further beta strand from the tail of the binding partner protein. The C-terminal carboxylate group is bound by a nest (protein structural motif) in the PDZ domain, i.e. a PDZ-binding motif.

Origins of discovery
PDZ is an acronym derived from the names of the first proteins in which the domain was observed. Post-synaptic density protein 95 (PSD-95) is a synaptic protein found only in the brain. Drosophila disc large tumor suppressor (Dlg1) and zona occludens 1 (ZO-1) both play an important role at cell junctions and in cell signaling complexes. Since the discovery of PDZ domains more than 20 years ago, hundreds of additional PDZ domains have been identified. The first published use of the phrase "PDZ domain" was not in a paper, but a letter. In September 1995, Dr. Mary B. Kennedy of the California Institute of Technology wrote a letter of correction to Trends in Biomedical Sciences. Earlier that year, another set of scientists had claimed to discover a new protein domain which they called a DHR domain. Dr. Kennedy refuted that her lab had previously described exactly the same domain as a series of "GLGF repeats". She continued to explain that in order to "better reflect the origin and distribution of the domain," the new title of the domain would be changed. Thus, the name "PDZ domain" was introduced to the world.

Structure

PDZ domain structure is partially conserved across the various proteins that contain them. They usually have 5-6 β-strands and one short and one long α-helix. Apart from this conserved fold, the secondary structure differs across PDZ domains. This domain tends to be globular with a diameter of about 35 Å.

When studied, PDZ domains are usually isolated as monomers, however some PDZ proteins form dimers. The function of PDZ dimers as compared to monomers is not yet known.

A commonly accepted theory for the binding pocket of the PDZ domain is that it is constituted by several hydrophobic amino acids, apart from the GLGF sequence mentioned earlier, the mainchain atoms of which form a nest (protein structural motif) binding the C-terminal carboxylate of the protein or peptide ligand. Most PDZ domains have such a binding site located between one of the β-strands and the long α-helix.

Functions
PDZ domains have two main functions: Localizing cellular elements, and regulating cellular pathways.

The first discovered function of the PDZ domains was to anchor receptor proteins in the membrane to cytoskeletal components. PDZ domains also have regulatory functions on different signaling pathways. Any protein may have one or several PDZ domains, which can be identical or unique (see figure to right). This variety allows these proteins to be very versatile in their interactions. Different PDZ domains in the same protein can have different roles, each binding a different part of the target protein or a different protein altogether.

Localization
PDZ domains play a vital role in organizing and maintaining complex scaffolding formations.

PDZ domains are found in diverse proteins, but all assist in localization of cellular elements. PDZ domains are primarily involved in anchoring receptor proteins to the cytoskeleton. For cells to function properly it is important for components—proteins and other molecules— to be in the right place at the right time. Proteins with PDZ domains bind different components to ensure correct arrangements. In the neuron, making sense of neurotransmitter activity requires specific receptors to be located in the lipid membrane at the synapse. PDZ domains are crucial to this receptor localization process. Proteins with PDZ domains generally associate with both the C-terminus of the receptor and cytoskeletal elements in order to anchor the receptor to the cytoskeleton and keep it in place. Without such an interaction, receptors would diffuse out of the synapse due to the fluid nature of the lipid membrane.

PDZ domains are also utilized to localize elements other than receptor proteins. In the human brain, nitric oxide often acts in the synapse to modify cGMP levels in response to NMDA receptor activation. In order to ensure a favorable spatial arrangements, neuronal nitric oxide synthase (nNOS) is brought close to NMDA receptors via interactions with PDZ domains on PSD-95, which concurrently binds nNOS and NMDA receptors. With nNOS located closely to NMDA receptors, it will be activated immediately after calcium ions begin entering the cell.

Regulation
PDZ domains are directly involved in the regulation of different cellular pathways. This mechanism of this regulation varies as PDZ domains are able to interact with a range of cellular components. This regulation is usually a result of the co-localization of multiple signaling molecules such as in the example with nNos and NMDA receptors. Some examples of signaling pathway regulation executed by the PDZ domain include phosphatase enzyme activity, mechanosensory signaling, and the sorting pathway of endocytosed receptor proteins.

The signaling pathway of the human protein tyrosine phosphatase non-receptor type 4 (PTPN4) is regulated by PDZ domains. This protein is involved in regulating cell death. Normally the PDZ domain of this enzyme is unbound. In this unbound state the enzyme is active and prevents cell signaling for apoptosis. Binding the PDZ domain of this phosphatase results in a loss of enzyme activity, which leads to apoptosis. The normal regulation of this enzyme prevents cells from prematurely going through apoptosis. When the regulation of the PTPN4 enzyme is lost, there is increased oncogenic activity as the cells are able to proliferate.

PDZ domains also have a regulatory role in mechanosensory signaling in proprioceptors and vestibular and auditory hair cells. The protein Whirlin (WHRN) localizes in the post-synaptic neurons of hair cells that transform mechanical movement into action potentials that the body can interpret. WHRN proteins contains three PDZ domains. The domains located near the N-terminus bind to receptor proteins and other signaling components. When the one of these PDZ domains is inhibited, the signaling pathways of the neurons are disrupted, resulting in auditory, visual, and vestibular impairment. This regulation is thought to be based on the physical positioning WHRN and the selectivity of its PDZ domain.

Regulation of receptor proteins occurs when the PDZ domain on the EBP50 protein binds to the C-terminus of the beta-2 adrenergic receptor (β2-AR). EBP50 also associates with a complex that connects to actin, thus serving as a link between the cytoskeleton and β2-AR. The β2-AR receptor is eventually endocytosed, where it will either be consigned to a lysosome for degradation or recycled back to the cell membrane. Scientists have demonstrated that when the Ser-411 residue of the β2-AR PDZ binding domain, which interacts directly with EBP50, is phosphorylated, the receptor is degraded. If Ser-411 is left unmodified, the receptor is recycled. The role played by PDZ domains and their binding sites indicate a regulative relevance beyond simply receptor protein localization.

PDZ domains are being studied further to better understand the role they play in different signaling pathways. Research has  increased as these domains have been linked to different diseases including cancer as discussed above.

Regulation of PDZ domain activity
PDZ domain function can be both inhibited and activated by various mechanisms. Two of the most prevalent include allosteric interactions and posttranslational modifications.

Post-translational modifications
The most common post-traslational modification seen on PDZ domains is phosphorylation. This modification is primarily an inhibitor of PDZ domain and ligand activity. In some examples, phosphorylation of amino acid side chains eliminates the ability of the PDZ domain to form hydrogen bonds, disrupting the normal binding patterns. The end result is a loss of PDZ domain function and further signaling. Another way phosphorylation can disrupt regular PDZ domain function is by altering the charge ratio and further affecting binding and signaling. In rare cases researchers have seen post-translational modifications activate PDZ domain activity but these cases are few.

Another post-translational modification that can regulate PDZ domains is the formation of disulfide bridges. Many PDZ domains contain cysteines and are susceptible to disulfide bond formation in oxidizing conditions. This modification acts primarily as an inhibitor of PDZ domain function.

Allosteric Interactions
Protein-protein interactions have been observed to alter the effectiveness of PDZ domains binding to ligands. These studies show that allosteric effects of certain proteins can affect the binding affinity for different substrates. Different PDZ domains can even have this allosteric effect on each other. This PDZ-PDZ interaction only acts as an inhibitor. Other experiments have shown that certain enzymes can enhance the binding of PDZ domains. Researchers found that the protein ezrin enhances the binding of the PDZ protein NHERF1.

PDZ proteins

PDZ proteins are a family of proteins that contain the PDZ domain. This sequence of amino-acids is found in many thousands of known proteins. PDZ domain proteins are widespread in eukaryotes and eubacteria, whereas there are very few examples of the protein in archaea. PDZ domains are often associated with other protein domains and these combinations allow them to carry out their specific functions. Three of the most well documented PDZ proteins are PSD-95, GRIP, and HOMER.

PSD-95 is a brain synaptic protein with three PDZ domains, each with unique properties and structures that allow PSD-95 to function in many ways. In general, the first two PDZ domains interact with receptors and the third interacts with cytoskeleton-related proteins. The main receptors associated with PSD-95 are NMDA receptors. The first two PDZ domains of PSD-95 bind to the C-terminus of NMDA receptors and anchor them in the membrane at the point of neurotransmitter release. The first two PDZ domains can also interact in a similar fashion with Shaker-type K+ channels. A PDZ interaction between PSD-95, nNOS and syntrophin is mediated by the second PDZ domain. The third and final PDZ domain links to cysteine-rich PDZ-binding protein (CRIPT), which allows PSD-95 to associate with the cytoskeleton.

Glutamate receptor interacting protein (GRIP) is a post-synaptic protein that interacts with AMPA receptors in a fashion analogous to PSD-95 interactions with NMDA receptors. When researchers noticed apparent structural homology between the C-termini of AMPA receptors and NMDA receptors, they attempted to determine if a similar PDZ interaction was occurring. A yeast two-hybrid system helped them discover that out of GRIP's seven PDZ domains, two (domains four and five) were essential for binding of GRIP to the AMPA subunit called GluR2. This interaction is vital for proper localization of AMPA receptors, which play a large part in memory storage. Other researchers discovered that domains six and seven of GRIP are responsible for connecting GRIP to a family of receptor tyrosine kinases called ephrin receptors, which are important signaling proteins. A clinical study concluded that Fraser syndrome, an autosomal recessive syndrome that can cause severe deformations, can be caused by a simple mutation in GRIP.

HOMER differs significantly from many known PDZ proteins, including GRIP and PSD-95. Instead of mediating receptors near ion channels, as is the case with GRIP and PSD-95, HOMER is involved in metabotropic glutamate signaling. Another unique aspect of HOMER is that it only contains a single PDZ domain, which mediates interactions between HOMER and type 5 metabotropic glutamate receptor (mGluR5). The single GLGF repeat on HOMER binds amino acids on the C-terminus of mGluR5. HOMER expression is measured at high levels during embryologic stages in rats, suggesting an important developmental function.

Human PDZ proteins

There are roughly 260 PDZ domains in humans. Several proteins contain multiple PDZ domains, so the number of unique PDZ-containing proteins is closer to 180.  In the table below are some of the better studied members of this family:

The table below contains all known PDZ proteins in humans (alphabetical):

There is currently one known virus containing PDZ domains:

References

Further reading

External links

 The PDZ Domain as a Complex Adaptive System  A concise technical summary and a statement of principal findings and ramifications of the PDZ Domain as a Complex Adaptive System
 NCBI conserved domains entry
 https://www.pdznet.eu - An EU project to advance our understanding of the cellular signaling pathways and therapeutic potential of proteins comprising PDZ domains in healthy and pathological conditions such as cancer and neurological diseases.

Protein domains
Membrane proteins


Do you want to go on a family vacation with all the comforts? This apartment in the center with cool terrace next to the large beach you will like! Large wardrobes, comfortable beds and suits, bright and light spaces and kitchen with views and exit to the terrace, the establishment will please you because it is located a few meters from the large beach, it has a quiet and very sunny terrace and is perfect for Families who want to make a long stay on the coast in summer.
Perfect for couples or families who want to enjoy the Costa Brava with 3 rooms for 6 people. Located in the center of Platja d'Aro this holiday apartment is located a few meters from the most central shopping area on the one hand and also a few meters from the sea, an ideal location to have everything you need on the edge to walk comfortably And without using your vehicle: forget about the road for a few days and enjoy the magnificent views of the Camí de Ronda, go to Sant feliu de Guixols or Palamòs, Girona or Figueres, the Empordà has a lot to discover and everything very close to your accommodation. Platja d'Aro, the largest outdoor leisure and entertainment center on the Costa Brava, will allow you to enjoy an excellent vacation thanks to the great offer of leisure and cuisine that you will find in the town and some excellent beaches. Do you want to sleep well?
The apartment is located in a quiet and neighborly neighborhood near the beach of Platja d'Aro, one of the most touristy and most attractive towns and activities on the Girona coast, but also the most familiar and safe: it has the Family Tourism Destination, becoming a town where security and family activities are always at the forefront! Girorooms rent tourism in Girona and the Girona coast Our apartments and houses are ideal for enjoying a few days of vacations near the best and best of our splendor and natural surroundings.


FaZe Rug is a gamer who is a co-founder and the most popular member of the famous gaming team FaZe Clan. He is a gamer and uploads videos of himself on YouTube while playing video games and teaching tricks.
FaZe is an inspiration for thousands of people out there who are trying their luck as a gamer or any other type of content creator of YouTube.
Considering the fact that he was born is 1996 and is still very young, his achievements seem to have more weight and influence. After starting from the very bottom, currently, FaZe Rug net worth is almost $1 million.
'FaZe Rug' is a name that he uses online corresponding to his team name 'FaZe Clan'. His real name is Brian Awadis and he belongs to Iraq.
Brian's parents lived in Iraq until the life in the country was not safe. So they decided to migrate to the United States. FaZe himself was born in San Diego, California on 19th November 1996 and is a US international himself.
Since FaZe was a kid, he was very much inclined towards gaming. His collection was filled with games like 'Call of Duty', 'Halo', and other games of the same genre.
Being an extreme game lover, he has spent a sizeable amount of time playing them and coming up with his personal techniques and tricks.
FaZe joined a small baseball league and played there for almost 3 years while he was in school. He started making videos of himself playing baseball and uploading them to YouTube.
But the physical sport couldn't provide him the fortune and fame he was destined to through virtual games.
After he joined college, FaZe came up with the idea of starting his YouTube journey again and so he started with computer games, which was the turning point of his life.
The successful start and a potential to make some handful of money made him drop out of the college in his very first year to concentrate full time on his income from YouTube.
Since FaZe came into the limelight, fans wanted to know who was his significant other. But he never answered that. Perhaps he was single at the time.
However, one of his brother's snapchat showed a picture of him trying to kiss a girl. When fans insisted him to reveal the identity of the girl, he released a video with the title 'Meet My Girlfriend'.
But the video was a prank on fans just like he keeps doing with his family members. The video showed him with a toy girl.
However, he later revealed that he is dating the bikini model Molly Eskam. Molly started appearing in his videos time and again.
After dating for a long time, the couple broke up and FaZe released a video telling his fans the reason for the break-up. In 2018, it was rumored that the couple is back again.
FaZe rose to the highest point of his career through his prank videos. He is often seen pranking his family which includes his mother, Mama Rug, his father, Papa Rug, and his brother Brandon.
Moreover, he is a family man and stars his parents in the videos to emphasize the importance of family in his life.
His channel 'FaZe Rug', which is a mixture of gaming and prank videos, has approximately 8.1 million subscribers. This is one of the reasons why FaZe Rug net worth is $1 million at the moment.
FaZe is also the director and the founder of 'FaZe Clan'. His team has people like FaZe Rain, FaZe Banks, FaZe Blaziken, FaZe Adapt, and many other famous gamers and YouTubers.
Brian C. Deroche is a student at the University of Michigan. He is a showbiz lover and loves to write about the life and gossip about celebrities.


No teacher ever took an interest in me the way Mr. Derm McDonald did when I was in grade 9 – the year that everything changed for me.
I guess I was doing OK before I met him, but I lacked confidence. I feel like my life could have headed in one of many directions…not all good ones. For the first time ever, a teacher really "got" me, and he saw what I needed: to be inspired. He helped me harness some really great skills…things I rely on 30 years later. Like the importance of word choice; the ability to tell a story; effortless confidence when addressing a large group of people; and humour as a tool to help people warm to you. Above all, he taught me about integrity. It was much later in life that the things I learned from him actually became clear. He was one hell of a teacher.
So, thank you, Mister Mac. Sensei. My life is pretty rich, and I am grateful to you for helping to shape that.


text:
Mars for the Many
Home›News›Science & Technology›Space Station Art from the 1970's - A Look Back to 1975
Stanford Torus Exterior. Designed for up to 10,000 people in one gigantic torus 1.8 km in diameter that rotated once per minute.The giant mirror was meant to redirect sunlight into the interior. Painting by Donald E. Davis
Stanford Torus - a cutaway view showing the community section of the main torus.
Stanford Torus - Construction techniques. The chevrons being installed were designed to reflect sunlight into the interior while at the same time offering radiation protection.
Stanford Torus Interior - the torus had a cross section of 430 feet. Painting by Donald E. Davis
Bernal Sphere Exterior - The Bernal Sphere was Gerard O'Neill's alternative to the Stanford Torus. The main sphere was 500m in diameter and rotated at 1.9 rpm. The main sphere could house 10,000 people, with a series of toroidal rings at either end for agriculture.
Bernal Sphere - Construction of the exterior shell
Bernal Sphere - looking through one of two transparent sections directly into the interior of the sphere. The glass panels were designed to admit natural light into the interior.
Bernal Sphere - Interior view. Human powered flight in the lower g sections near the core was just one of the recreational activities envisioned. The central core also contained swimming pools for low-g diving.
Bernal Sphere - View of the agricultural sections, in multiple, stacked toroids, with cutaway to expose interior.
Photographed model of the Bernal Sphere
O'Neill Cylinders - Gerard O'Neill also came up with a larger space colony design that was basically a 32km (20 miles) long cylinder, 8km (5 miles) in diameter. Two counter-rotating cylinders would rotate in opposite directions in order to cancel out any gyroscopic effects and make it easier to keep the mirrors pointed toward the sun.
O'Neill cylinder - Interior View. Each cylinder was divided into six sections equally spaced around the long axis of the cylinder. Three sections were for habitation - the other three were gigantic glass panels that let in natural sunlight redirected from exterior mirrors.
O'Neill Cylinder - Interior view. The ends of the cylinders were capped with hemispherical 'endcaps' that could be landscaped into large hills and mountains. In this image, a large suspension bridge mimics the Golden Gate bridge.
O'Neill Cylinder - Interior View. The cylinders were large enough that they would produce their own clouds and weather.
O'Neill Cylinder - Exterior View. Each cylinder included a ring of smaller modules at one end that were meant for agriculture, research labs, and manufacturing.
Evolution of a space Habitat - The designs depicted were derived from this simple diagram -- the Curreri Space Habitat Evolution -- and presented the summer of 1977 at NASA's 'pace Settlements - A Design Study'
Space Station Art from the 1970's - A Look Back to 1975
Space Station Designs Still Inspire 40 years Later
In the 1970's, toward the end of the Apollo program, U.S scientists and engineers debated the evolution of humans in space.
On to Mars? Or should we focus on building communities and industry in near earth orbits?
Advocates of near earth and lunar resource utilization met during NASA's 'Space Settlements - A Design Study' symposium in the summer of 1977 to present their views.
While their designs never came to fruition, they did help push U.S. policy toward LEO space stations (think Skylab) and the space shuttle -- and the rest is history.
It may all look a little quaint today -- but take a look at three of the most popular designs.
After 40-plus years, they still inspire.
What do you think? Do you like these pictures? Then share them with your friends.
Tagsspace settlementsspace station
Moon or Mars? Take the Poll and ...
Russian Rocket Engines Under Attack
Artificial Gravity is Critical to Space Exploration - So Why is it Being Ignored?
Will This Become The First Mars Airplane?
Are Robotic In-Orbit Services the Next Space Revolution?
Emily 10 June, 2017 at 08:17 Reply
How much would one of these paintings be worth? And have any of them been stolen?
Joel Ammons 10 June, 2017 at 10:51 Reply
Interesting questions, but frankly I have no idea.
JohnnySpacer 14 February, 2016 at 19:23 Reply
Human-made space colonies are the way to go for human colonization off-earth. Such space colonies are not subject to the gravity of a planet or a moon. It will not be subject to the environment of a planet or moon that would make human life very difficult. Space colonies can be made to order. They can be easily accessed without having to deal with gravity or dust.
NASA Mission To Search For Life On Europa
Spirulina Farming on Mars - an Alternative Food Source for Mars Colonies?
The Human Exploration of Mars
Mars Landers - A Chronology of Successful Landings on Mars (and some that weren't..)
National Geographic Releases Amibitious New Mars Trailer
Mars Seasons - Springtime in the South is Dust Storm Season
Mars Picture of the Week
Earth & Moon
© Copyright 2016 MarsfortheMany.com. All rights reserved.


text:
John Francis Clauser (* 1. Dezember 1942 in Pasadena, Kalifornien) ist ein US-amerikanischer Experimentalphysiker, der sich mit Grundlagen der Quantenmechanik beschäftigt. Im Jahr 2022 wurde ihm der Nobelpreis für Physik gemeinsam mit Alain Aspect und Anton Zeilinger zuerkannt. Er führte mit Stuart Freedman 1972 das erste Experiment durch, in dem die Verletzung der Bellschen Ungleichung (eine quantitative und experimentell überprüfbare Formulierung des EPR-Paradoxons) nachgewiesen wurde und damit die Gültigkeit der Quantenmechanik und Widerlegung der Theorie Verborgener Variablen, die von Physikern wie Louis de Broglie und David Bohm als Möglichkeit der Interpretation der Quantenmechanik im Rahmen der klassischen Physik diskutiert wurde. Gleichzeitig war dies der Beginn von Experimenten mit verschränkten Zuständen in der Quantenmechanik und machte ihn auch zu einem Pionier der Quanteninformationswissenschaft.

Leben

Clauser ist der Sohn eines Professors für Flugzeugbau (Francis Hettinger Clauser, 1913–2013) am Caltech und studierte am Caltech (Bachelor 1964) und an der Columbia University, wo er 1966 seinen Master-Abschluss machte und 1969 bei Patrick Thaddeus über die Messung des Kosmischen Mikrowellenhintergrunds promovierte. Danach war er bis 1975 am Lawrence Berkeley National Laboratory und 1975 bis 1986 am Lawrence Livermore National Laboratory. Anschließend war er als Forschungsphysiker an der University of California, Berkeley. In einem grundlegenden Experiment testete er mit Stuart Freedman die Bellsche Ungleichung, die sie zuvor zur CHSH-Ungleichung (Clauser, Michael Horne, Abner Shimony und Richard Holt 1969) verallgemeinerten. Das war die erste Beobachtung von Quantenverschränkung und das erste Experiment, das die Verletzung der Bell-Ungleichung zeigte (und damit die Quantenmechanik bestätigte). Das Experiment wurde später (um 1982) von Alain Aspect in verbesserter Form durchgeführt und die Verletzung der Ungleichung bestätigt. Danach befasste er sich mit Atom-Interferometern.

Er beschäftigte sich auch mit dem Einschluss von Plasmen mit magnetischen Spiegeln (Magnetische Flasche).

2010 erhielt er mit Alain Aspect und Anton Zeilinger den Wolf-Preis in Physik, und 2022 ebenfalls gemeinsam mit diesen beiden Forschern den Nobelpreis für Physik.

Weblinks

 Oral History Interview

Einzelnachweise

Physiker (20. Jahrhundert)
Nobelpreisträger für Physik
US-Amerikaner
Geboren 1942
Mann


text:
Syrians
Syrians, also known as the Syrian people, are the majority inhabitants of Syria and share common Levantine Semitic roots. The cultural and linguistic heritage of the Syrian people is a blend of both indigenous elements and the foreign cultures that have come to inhabit the region of Syria and govern its people over the course of thousands of years. The mother tongue of most Syrians is Levantine Arabic, which came to replace the former mother tongue, Aramaic, in the aftermath of the Muslim conquest of the Levant in the 7th century. The conquest led to the establishment of the Caliphate under successive Arab dynasties, who, during the period of the Abbasid Caliphate, promoted the use of the Arabic language. A minority of Syrians retained Aramaic which is still spoken in its Eastern and Western dialects. In 2018, the Syrian Arab Republic had an estimated population of 19.5 million, which includes, aside from the aforementioned majority, ethnic minorities such as Kurds, Armenians, Assyrians and others.
Syrian businessmen linked to Beirut blast explosives
Three Syrian businessmen have been linked to the purchase of the explosives that caused the Beirut blast last August. The link has..
WorldNews 15 Jan 2021


text:
Centre of Surgical Invention & Innovation
About CSii
Robotic Division
IMCC
Nathalie Duchesne
Peter Lovrics
Kathy Schilling
Julian Dobranowski
Colm Boylan
Ananth Ravi
Andrew Loblaw
Calvin Law
A clinical advisory group for IGAR breast has been composed and regularly consulted, giving medical and scientific expertise in their respective fields.
Dr. Nathalie Duchesne is a Breast radiologist, at Hopital du Saint-Sacrement, in Quebec City and an Academic Clinical Associate Professor at Universite Laval. Dr. Duchesne has been working in breast imaging and intervention since 1996 and is a pioneer in vacuum-assisted breast biopsy, having done many world and Canadian premieres for various devices.
Dr. Peter Lovrics, the head of general surgery and medical director of the ICU at St. Joseph's Healthcare Hamilton, has performed a clinical trial of a new technique of seed localization, using a radioactive "seed" to locate and identify the lesion, Dr. Loveric is quoted as saying, "With IGAR we have the ability to make the next step and use MRI guidance to place the seed in certain types of cancer that are invisible to ultrasound and x-ray mammography. We believe this will play a vital role for surgical guidance in excisional biopsy and breast conserving lumpectomy procedures."
Dr. Kathy Schilling, medical director of Breast Imaging & Interventionat the Center for Breast Carein Boca Raton, Florida is also an integral part of the clinical advisory group. Dr. Schilling is well recognized as a leading clinician in the area of breast therapeutics. Her experience in breast MRI, and understanding of unique patient sensitivities have provided the IGAR team with both process and market insight into the way IGAR will integrate into the clinical environment. The Boca Centre is one of the largest private clinics in North America, and will serve as a leading centre in the United States for the evaluation of the IGAR clinical system.
Dr. Julian Dobranowski, anAssociate Clinical Professor of Diagnostic Imaging at McMaster University, the Director and Founder of the Centre of Radiological Anatomy, the Provincial Medical Imaging Lead for Cancer Care Ontario and the National Chair of the Canadian Association of Radiologists. Dr.Dobranowski continues to serves as the Clinical Lead for the IGAR Breast Investigation Team. His extensive experience in diagnostic imaging has proven critical in the correct definition of patient care pathways and clinical requirements for the breadboard prototype. His involvement has also allowed CSii to quickly access top diagnostic imaging experts throughout the province. Dr. Dobranowski's involvement has provided input into the 3D imaging system for IGAR that will enhance clinician experience,
Dr. Colm Boylan, is also a noteworthy clinical advisor, as theChief of the Department of Diagnostic Imaging at St. Joseph's Healthcare Hamilton. Dr. Boylan's research interests are in thoracic and breast imaging, specifically new CT and MRI techniques and image-guided procedures.
Dr. Ananth Ravi, is the clinical operations lead of brachytherapy services at Sunnybrook Odette Cancer Centre.
Dr Andrew Loblaw, is a Radiation Oncologist, Clinician Scientist, and Professor in the Department of Radiation Oncology at Sunnybrook Health Sciences Centre. Dr Loblaw's clinical practice and research interest focus on improving outcomes for men with prostate cancer and the healthcare system.
Dr. Calvin Law, is the Chief, Edmond Odette Cancer Centre, Sunnybrook Health Sciences Centre and Regional Vice President, Cancer Care Ontario.
© 2013 Centre for Surgical Invention & Innovation
Quick Links | Terms of Use | Privacy Statement
Website by 2Gen Interactive


The Nature In Us: Why Do Cats Purr?
As a veterinarian, I am commonly asked "Why do cats purr?" Most people believe cats purr when they are content or happy. While cats do purr when they are content, researchers attempting to uncover the answer to this 3,000-year-old mystery are finding the answer more complicated than previously thought.
All domestic cats purr, as well as many wild cats, like pumas, ocelots, lions and cheetahs. Purring can occur in a variety of situations.
When cats purr in the presence of other unknown cats or kittens, the behavior may serve to convey submissiveness or a friendly greeting.
While it is true that cats purr contentedly while on their pet parent's lap, they also purr when they give birth, when they are frightened, severely injured and even while dying. Because kitties clearly cannot be content in all these situations, contentment or friendliness cannot be the only reason they purr. So why else would they purr?
The photo(s) and article are copyrighted. You may use either of them if you include the following credit and active link back to this website:© 2010 Donna L. Watkins - This article was reprinted with permission from TheNatureInUs.com. The link to use is: www.TheNatureInUs.com.


Animals Taught Me That is an encouraging memoir and detailed account of how Kim Bloomer learned all the most important lessons life has for us through the love and friendship of God's creatures.
From her earliest childhood memories with animals to her late beloved dog, Shadrach the Neo Mastiff, Dr. Kim shares in Animals Taught Me That (Crossbooks Publishing; publication date December 2, 2009) how God has used His creatures to teach her the life lessons we need to grow in character and integrity.
Through her trials and errors, often at the expense of a beloved pet, Kim shares her mistakes and encourages the readers to learn from them.
The most important aspect of this book is how selflessly animals are in teaching us without judgment. Cry and laugh with Kim as you journey through the stories of all the animals that have graced her life, including both wild and domestic.
Kim's hope is not only that you will learn life's most important lessons, but that the animals in your life will be honored for who they are and how much they really do mean in our lives.
Beautifully illustrated by professional artist, Barbara Hilford, the illustrations bring the animals to life to tug at your heartstrings and woo you through the pages of Animals Taught Me That.
… plus most of them have also been guests on our radio show, Animal Talk Naturally, so you'll want to go listen to those interviews. They have some wonderful books that will help people learn about natural animal health, animal nature, and the human-animal bond.
The very BEST!!! of luck with your new book, Kim! Thank you for letting us know about it. And THANK YOU for including the information about Ron's work. Very kind of you!! Hope you had a Happy Thanksgiving.
Congratulations Kim! The book looks wonderful and so does the website! Thank you for listing my books in yours.
Congrats on the new book, you know I'll have to have you on the show again! I'm going to announce it on tonight's show. Thanks so much for adding me to your suggested reading! You have been a great friend since we started!
Wow, you have busy! I'm excited for you and can't wait to read more.
Kim, Congratulations on your new book and for passing on information about Something About Women Radio. All the best, Francine Silverman, author of Talk Radio Wants You!
Your cover is beautiful. Tell your illustrator she did a fantastic job. God;s blessings on this book.


New Issue Available! - The BBQ BRETHREN FORUMS.
Issue 21 is now available!
Completely free and by the community.
Eric, maybe it's the work computer but I can't seem to pull up the new issue.
Is this the url you used?
Eric, I clicked on the "current issue" in your sig line.
When I click that, it brings up the Signals Home Page but not the current issue.
Thanks! It should be fixed now.


text:
Whole-body Cryotherapy as a Recovery Technique after Exercise: A Review of the Literature
In the days following unaccustomed or intense training or competition, athletes often experience dull, aching pain, stiffness, and loss of muscle strength that can last for up to 5-7 days. This phenomenon is termed exercise-induced muscle damage (EIMD). Muscle damage is characterized by a sustained reduction in optimal force production, the delayed onset of muscle soreness (DOMS), and an acute inflammatory response. It has been proposed that cold therapies aid recovery following EIMD through a dampening of the inflammatory response, edema reduction, and through an analgesic effect.
A novel form of cold therapy, Whole Body Cryotherapy (WBC) has gained popularity in athletes as an anti-inflammatory treatment. A typical session of WBC involves standing in a chamber that fills with a safe, but extremely cold gas, maintained at temperatures of -110 degrees Celsius to -190 degrees Celsius (-166 to -220 degrees Fahrenheit) for at least two minutes and a maximum of five minutes. The authors in the study, Whole-body Cryotherapy as a Recovery Technique after Exercise: A Review of the Literature, present an overview of the current research on the topic and provide recommendations for its use by athletes.
Four key outcome measures for EIMD utilized in this review include pain, muscle function and performance, inflammatory marker levels, and creatine kinase (CK) levels as a marker of muscle damage.
The visual analog scale was utilized in the five articles that used pain as an outcome measure. Four studies found a significant decrease in pain by at least 18% when compared to a control at 48 hours post WBC treatment. In one study, there was also decreased pain compared to the control group when performing a body weight squat post-WBC treatment, suggesting WBC treatment may reduce pain during subsequent muscle contractions.
Muscle Function and Performance
Patients received an average of 15 WBC treatment exposures across the six studies that measured muscle function. In one study, a group of tennis players were exposed to WBC every day over a five-day training program. In this study, the WBC group reached fatigue significantly later during a progressively more difficult tennis drill than a control group. The WBC group also experienced a 7.3% increase in stroke effectiveness during a tennis skill game that became progressively more difficult where the control group only increased by 2.6%. In another study, synchronized swimmers were exposed to WBC each day during a period of intensified training and found that a 400 m time trial swim speed was only 0.5% slower after WBC compared to a 1.1% time reduction in the group that did not receive WBC treatment.
The authors who focused on inflammatory marker levels used concentrations of interleukins, tumor necrosis factor (TNF), and C-reactive protein (CRP) to show the amount of inflammation present in the muscle. One study looked at the inflammatory response in runners following a 48-minute simulated trail run. Concentrations of the acute inflammatory marker, CRP, were increased by 515% from baseline in the control group and 123% in a WBC group. The increase of inflammatory interleukin cells that naturally occurs after damaging exercise was limited when participants were exposed to WBC compared to the control.
In another study which observed the effects of WBC prior to exercise, the concentration of the pro-inflammatory interleukin increased more than six times in the control group compared to athletes who were treated with WBC. In addition, interleukin concentration dropped by 11%, indicating that treatment blunted the inflammatory response and possibly reduced muscle damage. Yet another study found WBC increased the concentration of an anti-inflammatory cytokine to twice that of baseline compared to no change relative to baseline in the control group. Further, the interleukin concentrations dropped by 80 % in the WBC group compared to a drop of only 50% in the control subjects . The final study found that a five-day training protocol combined with WBC induced a 60% decrease in the inflammatory cell, TNF-α.
Muscle Damage
Muscle damage focused studies used a measure of CK to determine the amount of breakdown in muscles. One study showed a 30% decline in CK after ten exposures to WBC over a five-day period as compared to a control group. A second study reported that CK concentrations were 34% lower with the inclusion of WBC treatment six days into a training protocol compared to a training protocol without WBC treatment. These results were supported by a separate study that reported daily exposure to WBC over a five-day training program with elite rugby players reduced CK by 40%. Another study found WBC treatment significantly reduced CK in tennis players where concentrations of this muscle enzyme in the control group remained virtually the same after five days of training. A final study found no significant changes in CK relative to a control group with protocols using either three or six exposures to WBC. The results from this study suggest that there may be a dose response to WBC when assessing CK concentration, where a reduction in circulating CK is in proportion to the number of exposures to WBC during the recovery process.
The lack of ability to blind for recovery treatment in the research makes it impossible to eliminate the potential placebo effect. Further investigation into the effects of multiple WBC exposures during extended periods of athletic training is warranted to determine potential effects on recovery, performance and processes of muscle adaptation. Future studies will require larger sample sizes to determine the significance of immunological changes and stringent methodological control to identify the exact influence of WBC on these pathways.
In conclusion, the studies referenced in this article suggest that WBC may be successful in decreasing pain, inflammation, and muscle damage and increasing muscle function. With WBC treatment groups recording pain scores an average of 31% lower than control groups, evidence tends to favor WBC as an analgesic treatment after damaging exercise. Data from inflammatory markers and CK suggest that WBC may dampen the inflammatory cytokine response which means less tissue damage and a faster recovery. Multiple exposures of three or more sessions of three minutes conducted immediately after and in the two to three days post-exercise have presented the most consistent results. There are contraindications to this modality including hypertension, circulatory disorder, and history of a stroke, to name a few. The athlete or patient needs to be properly screened and perform a thorough healthy history prior to treatment.
PT First Implications
As the research on WBC continues to evolve, this treatment could be a good adjunct to skilled physical therapy during an athlete's training. Localized cryotherapy is a common modality seen in a physical therapy setting to treat pain and inflammation. WBC provides an avenue to treat more widespread muscle pain in multiple area of the body and could be beneficial for athletes during their training season.
Rose, C., Edwards, K., Siegler, J., Graham, K., Caillaud, C (2017). Whole-body Cryotherapy as a Recovery Technique after Exercise: A Review of the Literature. International Journal of Sports Medicine. 38: 1049-1060.


text:
Netflix Original – Dragons: Race to the Edge – Season 2
Publish in :Kids, TV Shows
DreamWorks Dragons is an American computer-animated television series airing on Cartoon Network based on the 2010 film How to Train Your Dragon. The series serves as a bridge between the first film and its 2014 sequel. Riders of Berk follows Hiccup as he tries to keep balance within the new cohabitation of Dragons and Vikings. Alongside keeping up with Berk's newest installment — A Dragon Training Academy — Hiccup, Toothless, and the rest of the Viking Teens are put to the test when they are faced with new worlds harsher than Berk, new dragons that can't all be trained, and new enemies who are looking for every reason to destroy the harmony between Vikings and Dragons all together.
DreamWorks Dragons: Riders of Berk
DreamWorks Dragons: Defenders of Berk - Trailer
Dragons: Race to the Edge | Official Trailer
Dragons: Race to the Edge | Season 2 Trailer
This serie is not available on Netflix in your country? The solution is:
Stream it on [insert_php] echo get_bloginfo( 'name'); [/insert_php]
Categories Kids, TV Shows	Tags Adventure, Animation, Comedy
Previous: Screwed
Next: Kurt Cobain: Montage of Heck


The aging process of your body is primarily dependent on the condition of your arteries. If you remember nothing else — I want you to realize the monumental role your arteries play on the chronological aging of your body. The flow of blood through your body carries nutrients, oxygen, electrolytes, and essentials that keep the body running like a new engine. That blood is pumped through your system by the heart and is carried by 60,000 miles of arteries, plus veins. The condition of the arteries determines how well the body is supplied with all it needs to function at one hundred percent perfection. As those arteries become damaged, the walls begin to fill up with factors that eventually cause a blockage. There is either plaque build up or inflammation that can result in a clot. Both events can cause the blood flow to either completely stop or become markedly decreased. The downstream area becomes starved for oxygen. Over half of all Americans will die as a result of damage to the arteries of the heart or brain. Don't become one of the statistics. Read Prescription For Life and learn what the medical literature has to say about prevention of the aging process.


Felix has a fresh sound and understanding when it comes to electronic and pop tying in together for the best of both worlds. He has an appreciation for commercial music while many in the EDM scene don't. Felix Cartal comes off more as a songwriter and real musician producer than your average DJ. That said he still has the charm and personality to make you want to listen to his unique & stellar production work.
"Sometimes I feel like I don't communicate properly in relationships, because songwriting sessions often act as their own form of therapy."
I've always loved listening to music growing up, and when I was 13 years old I bullied my way into my friends' band when they fired their singer. Throughout high school we wrote and made music and after we disbanded I started to do my own thing.
The Beatles, Pink Floyd, Steely Dan, Radiohead.. I don't know weird stuff, I can go on for hours. Even The WEEKEND and slowed down stuff like that.
You hail from Canada. Do you feel that the scene over there is being dwarfed by America's insatiable hunger for EDM?
I feel like we are a part of it. Dance music is very healthy in North America right now, I feel fortunate to be a part of the scene as it is thriving.
Your sound is pretty unique. Do trends influence your sound or you rather stick to your own inspirations?
I think I'm aware of trends but don't try to play into them too much. I think if you can use sounds that are current and channel your own inspirations and honesty through them, then you will get the best result. I haven't perfected this yet, but I'm always learning, always trying to get better.
What's your favorite DJ in general?
Style of Eye, I think he´s amazing. His tracks are like a journey, they start at one place and end up in an other and his album is a great balance of serious melodies but they´re still very fun. That´s the perfect thing to do which is always hard because you don´t want to be too serious and depress the people in the club but you don´t wanna be so cheesy that it´s like corny. He travels the line really well, very intense and melodic stuff but when it comes down it´s still a good party.
You've become known for producing music. What led to your becoming interested in that side of the business?
Producing electronic music was really fascinating to me because it felt way more free than being in a band. I liked the idea that you could make a multitude of different sounds and pull from a wider range of influences rather than being pigeonholed to one thing.


In this file photo, Jay Inslee speaks with reporters following an appearance in January at Saint Anselm College in New Hampshire.
A Tri-Cities man who has been a frequent online critic of Washington Gov. Jay Inslee said he was blocked this month from commenting on Inslee's campaign Facebook page. The move comes as Inslee, a Democrat, launches his candidacy for president and his campaign says its working to make his Facebook page "a little less toxic."
Jeff Kruger, a developer and builder in Kennewick, said he noticed on March 7, six days after Inslee announced his bid for president, that he could no longer post comments to Inslee's non-official Facebook page and that his previous posts had been deleted.
Kruger said he actively engages with Northwest politicians and participates in Facebook's "town hall" function which allows him to follow his elected officials. He has also given Facebook his address so that he can be identified with a "constituent badge" when he comments on the Facebook pages of politicians who represent him.
Raad would not confirm whether the campaign has started blocking critics, but in a follow up email said, "We are trying to make Facebook, at least our Facebook page, a little less toxic."
Kruger said around the same time he was blocked on Inslee's campaign page, he noticed that the number of comments on some of Inslee's more recent Facebook posts seemed to have gone down, not up since the last time he looked.
As governor, Inslee also has an official @WaStateGov Facebook page. Kruger isn't blocked from that page and recently posted there about being blocked on the @jayinslee page. A spokeswoman for the governor's office said their policy is not to block anyone from social media.
"If you are an elected, public official your best strategy is never to block somebody from weighing in on a social platform that you have created," Holcomb said, "but instead to have your administrators review any post that might fall outside of a comment on a public matter or may be threatening or harassing."
In court, Inslee would likely argue the page is now being used to promote his presidential campaign and is unrelated to his official work as governor, and therefore does not constitute a "limited public forum" where First Amendment rights are protected.
Jeff Kruger posted to Gov. Jay Inslee's official Facebook page after he was blocked from posting on Inslee's campaign page.


The Sixth Avenue Bridge geotechnical boring program will begin Monday, March 19th and should be complete before April 6th, weather permitting. Work will be completed during daytime hours, and one lane of alternating traffic is expected to remain open via a flagman. The work being performed is part of the current Local Concept Development Bridge Study. The borings will help obtain information on the physical properties of subsurface soil and rock around the bridge. That information will contribute to discussions about future design considerations.


text:
Archery Season opens Saturday, September 14
Wednesday, September 11. 2013
Deer hunting season is one of the most highly anticipated times of the year for many in the state, according to the Georgia Department of Natural Resources' Wildlife Resources Division. Archers get the first opportunity at bringing home a deer beginning Saturday, Sept. 14.
Last year, 113,566 archery hunters harvested more than 60,190 deer. Statewide archery season runs through Oct. 11, although hunters may hunt deer with archery equipment through the entire deer season (Jan. 1 in Northern Zone and Jan. 15 in the Southern Zone).
"Spring and summer seasons with abundant rainfall, like Georgia has experienced this year, generally produce abundant natural foods," said John W. Bowers, chief of Game Management. "These conditions often contribute to an increase in deer quality, but can also make it a challenging year to hunt deer."
Beginning this season, the number of firearms either-sex days is reduced in most counties. A few factors went into this decision, including the decline in the number of fawns that survive into fall and an increase in doe harvest rates. These factors warranted regulatory changes to reduce the doe harvest. For more information on this change, visit www.eregulations.com.
Many public lands offer specialty hunts, including primitive weapons hunts, adult/child hunts and ladies-only hunts. Dates and locations for these hunts are listed in the 2013-2014 Georgia Hunting Seasons and Regulations guide. Georgia offers more than 90 state-operated wildlife management areas (WMAs) for the public's use.
State-managed public hunting lands are funded through a combination of state license fees and matching federal funds from the U.S. Fish and Wildlife Services' Wildlife Restoration Program. Hunters account for $977 million in retail sales in Georgia each year with a $1.6 billion ripple effect and almost 24,000 jobs.
Hunters are allowed a season bag limit of ten antlerless deer and two antlered deer (one of the two antlered deer must have a minimum of four points, one inch or longer, on one side of the antlers). Special regulations apply to archery-only counties and extended archery season areas. Counties in the Metro Atlanta area (Clayton, Cobb, DeKalb, Forsyth, Fulton, Gwinnett, and Rockdale counties) offer either-sex archery deer hunting Sept. 14-Jan. 31.
To pursue deer in Georgia, hunters must have a valid hunting license, big game license and a current deer harvest record. If hunting on a WMA, a WMA license is required. Licenses can be purchased online at www.gohuntgeorgia.com, by phone at 1-800-366-2661 or at a license agent (list of agents available online).
For more information on deer hunting seasons, regulations, licenses and WMA maps, visit www.gohuntgeorgia.com/hunting.


UPDATED: Sat., June 3, 2017, 10:56 p.m.
First half—1, Venezuela, Velazquez (Moreno), 29th minute. Second half—2, United States, Pulisic (Johnson), 61st minute.
Yellow cards—None. Red cards—None. Referee—Jeffrey Solis, Costa Rica. Linesmen—Osvaldo Luna, Costa Rica; Alejandro Camarena, Panama. A—17,315.
SANDY, Utah – Adjusting to altitude and blending in players returning from injuries produced an uneven game for the United States.
Christian Pulisic scored early in the second half, defender John Brooks limped off with a hip injury and the Americans played a 1-1 exhibition tie against Venezuela on Saturday night, a warmup for a pair of World Cup qualifiers next week.
Jose Manuel Velazquez put Venezuela ahead in the 29th minute, but the 18-year-old Pulisic tied it in the 61st with his fifth goal in 15 international appearances.
The U.S. plays Trinidad and Tobago on Thursday at Commerce City, Colorado, then is at Mexico three days later. Rio Tinto Stadium is about 4,500 feet above sea level, preparation for matches in Colorado (about 5,200 feet) and Azteca Stadium (7,820 feet).
The U.S. is fourth in the final round of qualifying in North and Central America and the Caribbean with four points, ahead of Honduras on goal difference. Mexico leads with 10, followed by Costa Rica with seven and Panama with five. Trinidad is last with three.
The U.S. started close to a first-choice lineup, missing only forward Jozy Altidore, who reported late to training camp because of his brother's wedding. The center back pairing of Brooks and Geoff Cameron, starting together for the first time since October, was not sharp.
Brooks, who missed a March 28 qualifier because of a sinus infection, hobbled off in the 51st minute with a bruised right hip and was replaced six minutes later by Matt Hedges.
Velazquez scored his third international goal after Junior Moreno's corner kick was headed by Pulisic only for the ball to stay in the penalty area. Clint Dempsey headed the ball again in another clearance attempt, but it went wide to Moreno.
Moreno headed the ball back into the penalty area to Velazquez, who moved between Brooks and Fabian Johnson, stuck out his right foot at the top of the 6-yard box and poked the ball past goalkeeper Tim Howard.
Venezuela nearly doubled the lead five minutes later. Moreno sent a corner kick across the penalty area and Rubert Quijada had an open diving header at the 6. Howard dived to push the ball off a post, and the ball bounced across the goalmouth, where it was cleared by Bradley.
The U.S. did not have a shot on goal in the first half.
Pulisic tied the score after taking a pass from Johnson at the top of the penalty area. He took two touches with his right foot to create space from Christian Santos and beat goalkeeper Jose Contreras with a 16-yard left-footed shot.
The U.S. had rainbow numbers on its red jerseys as part of an initiative with You Can Play Project, which promotes equality without regard for sexual orientation and/or gender identity. The jerseys will be auctioned online for charity.
DeAndre Yedlin was at right back and Jorge Villafana at left back. Bradley was in defensive midfield and Pulisic in central midfield, flanked by Johnson on the right and Darlington Nagbe on the left. Dempsey and Bobby Wood headed the attack.
Yedlin, Johnson and Wood missed both March qualifiers because of injuries.
Venezuela is last in South American qualifying with six points in 14 games and has been eliminated. About two hours after the end of the friendly, the U.S. and Venezuela met in the quarterfinals of the Under-20 World Cup at Jeonju, South Korea.
Published: June 3, 2017, 9:17 p.m. Updated: June 3, 2017, 10:56 p.m.


Shops - StraVEGANte s.a.s. di Brachet Contul Tiziana & C.
If you would like to purchase any of our products, and you don't live close to any of the shops and stores listed, then please speak to your local delicatessen or gourmet food supplier about us. We're happy to supply our produce even in relatively modest amounts and will do all we can to establish new partnerships!


Bespoke and hand carved. Practical and hard wearing this ring could make a great eternity ring. Diamond is the "Stone of Invincibility" bringing victory, superior strength, fortitude and courage to its wearer. It is associated with lightning and fearlessness, and for its properties of protection. It is a symbol of wealth and manifesting abundance in one's life.


text:
SCOTTY McCREERY ANNOUNCES PLANS FOR A EUROPEAN TOUR IN MARCH 2022
By Hannah Compton on November 11, 2021 • ( Leave a comment )
The 'You Time' singer-songwriter will return to Germany, and play the Netherlands for the first time
Following the release of acclaimed new album Same Truck, featuring his fourth consecutive U.S. No. 1 hit single 'You Time', country star Scotty McCreery has today announced a European tour for next year, including three dates in Germany, where he played a run of sellout shows in 2019, and his first performance in Amsterdam. Tickets for all four dates will be on sale tomorrow (12/11) at 10am CET / 9am GMT.
This follows the previously announced main stage appearances at next year's C2C Festival in the UK & Ireland (tickets on sale now), and Scotty's forthcoming fifteen-date headline tour across the USA.
"Growing up in North Carolina, it was always a dream of mine to be able to perform my music around the globe," shared the artist. "I am looking forward to playing C2C in March in the UK and Ireland, but was also hoping we could return to Germany after we had such a great time there a couple of years ago. I'm really happy to be able to perform in Hamburg, Frankfurt, and Munich and get to know those cities. I'm also very excited about visiting the Netherlands for the first time as I've heard such great things about Amsterdam. Can't wait to see everyone!"
Full UK / European tour dates below:
Friday, 11th March 2022 – Dublin, Ireland – 3Arena
Saturday, 12th March 2022 – London, England – O2 Arena
Sunday, 13th March 2022 – Glasgow, Scotland – OVO Hydro
Wednesday, 16th March 2022: Hamburg, Germany – Bahnhof Pauli
Thursday, 17th March 2022: Frankfurt, Germany – Zoom
Friday, 18th March 2022: Munich, Germany – Hansa 39
Saturday, 19th March 2022: Amsterdam, The Netherlands – Melkweg OZ
The release of McCreery's fifth album Same Truck in September was met with applause from fans and critics, with Billboard sharing that the hitmaker "continues proving his mettle not only in the recording booth, but in the writing room, as a co-writer on the bulk of the project's songs," while Tennesseanshares, "McCreery walks a sonic tightrope that leans into his country influences while not abandoning modern Music Row hitmaking."
Giving fans a taste of what to anticipate on his tour dates, Scotty performed his latest single 'Damn Strait' on fellow American Idolwinner Kelly Clarkson's The Kelly Clarkson Show last week, an early favourite from the album after Rolling Stone named the track a "Pick of the Week" – watch the performance here.
ABOUT SCOTTY McCREERY:
Scotty McCreery's new album Same Truck is available now everywhere music is sold. It contains his fourth consecutive No. 1 single 'You Time' and the fan-favourite 'Damn Strait' the second single from the album impacting US Country radio now. He achieved new heights by earning three back-to-back No. 1 hits from his album Seasons Change, the RIAA Gold-certified project which debuted at No. 1 on the Billboard Country Album chart: the RIAA Double Platinum-certified 'Five More Minutes', the RIAA Platinum-certified 'This Is It', which stayed at the top of the charts for two weeks, and RIAA Gold-certified 'In Between'. McCreery co-wrote all 11 songs on Seasons Change, which Rolling Stonenamed as one of the "40 Best Country and Americana Albums of 2018." All four of his previous albums have debuted at No. 1 on a Billboard Albums chart, with current combined sales surpassing 3 million copies.
He's earned one Double Platinum, four Platinum and two Gold singles; won the 10th season of "American Idol" in 2011; was named the ACM New Artist of the Year in 2011; won the CMT Music Award for Breakthrough Video of the Year ('The Trouble with Girls') in 2012; American Country Awards for New Artist of the Year in 2011 and Breakthrough Artist of the Year in 2013; BMI Awards for writing One of the Top 50 Country Songs of the Year three times (in 2015 for 'See You Tonight', in 2018 for 'Five More Minutes', and in 2019 for 'This is It'); a Carolina Beach Music Award for National Dance Song of the Year ('Barefootin'') in 2018; and the NSAI Nashville Songwriter Award for One of the Top Ten Songs I Wish I'd Written ('Five More Minutes') in 2018. The North Carolina native released his first book, Go Big or Go Home: The Journey Toward the Dream, in 2016; it was re-released in paperback in 2020. McCreery launched his recording career by making history in 2011 as both the first country artist and the youngest male artist of any genre to debut his first studio album, the Platinum-certified Clear as Day, at No. 1 on the all-genre Billboard Top 200 Albums chart.
Categories: Country 2 Country Festival (C2C), Latest, News
Tagged as: Building Our Own Nashville, C2C, C2C Festival, Country 2 Country, Scotty McCreery, UK Country Blog, UK Country Music, Uk Country Music Blog, UK Country Music Magazine, UK Country Music Review, UK Country Music Website
Tenille Townes Sheds Her Mask On New Song 'Villain In Me' First Headlining U.S. Tour, Villain In Me Tour, On Sale Now. Tenille also to play C2C Festival
Taylor Swift – Red – Taylor's Version Album Review. Songs from The Vault and that All Important 10 Minute Version of All Too Well


I've been called "The SEO Agency Consultant", "an Awesome SEO Trainer" and "the guy who made our head spin and our revenue skyrocket", traveling around the country instilling best practices in sometimes not-so-best practices environments. You can be the agency that stands out among the others in the SEO community, and I'll show you how in less than three days.
On my first visit, I'll be asking a lot of questions. I'll ask to see current process models, project life cycle documents, organization (org) charts, vendor lists, report samples, software usage lists and more. I'll have a number of group and private interviews with employees and managers. I'll be taking a ton of notes and recording every pain point and every word of feedback from your respective teams.
I'll then return to my hotel (or some quiet place at or near your location) to compile all the findings and build a presentation with recommendations, most likely based on your current processes to make change as transparent as possible.
Depending on your individual needs, I may have one training session with your production team, followed by a training session with your sales team (I have a 90 percent close rate, and I'll show you my scripts). I'll have with me sample documents, proposal templates, a list of software and web apps I use, SEO audits, SEO strategic plans and other materials you'll be allowed to replicate as part of the training.
When I leave, your team's confidence in their search engine optimization ability will be improved exponentially. Your reports will gleam with enhancements, and your clients will get the results you've been promising them.
The SEO training program I've developed typically renders a return on investment from the sales side of the business within the first 45 days, with most SEO contracts ranging from $4k to $150k in value (over the life of the contract). Therefore, I try to keep my fees competitive and reasonable.
As of January 2016, my program fee is a flat $5,000. I'll pay for my own travel and lodging. If you are interested in having me train your SEO team, please call (562) 732-4417. I look forward to working with you and helping you increase your SEO sales and improve your service delivery.