text:
Thailand's Nirun Sae-ueng ended a four-year title drought on the Asian Development Tour (ADT) after defeating local hotshot Gavin Green on the first extra hole at the PGM Maybank Championship on Saturday.
Kuala Lumpur, Malaysia, November 30: Thailand's Nirun Sae-ueng ended a four-year title drought on the Asian Development Tour (ADT) after defeating local hotshot Gavin Green on the first extra hole at the PGM Maybank Championship on Saturday.
Nirun and Green both staged a remarkable comeback from six and eight shots back at the start of the day to end regulation play tied on 15-under-par 273 after posting final rounds of six-under-par 66 and 64 respectively at the Saujana Golf and Country Club.
While Green impressed with his flawless round that contained eight birdies to claim the clubhouse lead, it was Nirun who made heads turn when he eagled just when it mattered most, on the 18th, to overturn a two-shot deficit and force extra-time.
The duo returned to the par-five 18th hole for the play-off battle where Nirun pipped Green with a par against a bogey to triumph at the US$54,000 event.
Thai overnight leader Atiruj Winaicharoenchai failed to convert his commanding four-shot advantage into victory after battling to a 74 to finish sole third on 275, while Amir Nazrin finished one shot further back after closing with a 71.
Nirun admitted that he was left in disbelief when he eagled the last hole.
"I knew it was going to be tough to overtake Gavin, who was two shots clear at the top. For the last hole, I was just trying to finish with a flourish by aiming for a birdie.
"I hit my shot to about 75 yards and tried to chip onto the green. I didn't think it would go in!
"I didn't notice it went in as the pin was behind the hill. I only realised I made the eagle when I heard the loud cheers and fellow players came to congratulate me as I approached the green.
"But the eagle on the 18th really set me up well for the extra hole. Gavin would have a great advantage as he's capable of hitting it real far. I just focused on my game, put the ball on the fairway, and then the third shot to the green.
"I two-putted for the win after Gavin failed in his chip-in attempt and missed the putt as well," said Nirun, who pocketed US$9,529 to move from 51st to 19th on the Order of Merit.
Having collected US$14,842 from nine starts, Nirun has set his sights on claiming a big share of the season-ending US$160,000 Taifong Open in Chinese Taipei next month to make his last-ditch bid to crack into the top-seven.
"The victory has opened up the opportunity for me to try sneak into the top seven.. The Taifong Open is a big money event and I can still earn my Asian Tour card if I could finish top three there.
"Winning my first ADT title in four years has restored my confidence and ambition," he said.
Maybank ambassador Green was meanwhile philosophical in his defeat.
"I'm disappointed in the playoff of course but I had a good final round. Putts went in and I hit it great to make 17 out 18 greens, I would say it's still a solid week.
"I have been working really hard on some stuff with the swing and I'm liking the way I'm striking it. It's a great preparations for the next year's Maybank Championship, that's for sure," said Green.
Order of Merit leader Naoki Sekito of Japan could only manage to finish tied 30th but it was good enough for him to keep himself at the top on US$50,278, giving him a US$21,000 cushion over second-placed Pannakorn Uthaipas of Thailand (US$29,794).
But with the Taifong Open offering a top prize worth US$28,000, as many as six contenders including seventh-placed Kosuke Hamamoto of Japan (US$22,449) can still topple Sekito to become the ADT number one.
Atiruj Winaicharoenchai of Thailand is on the brink of securing his first Asian Development Tour (ADT) victory after firing a seven-under-par 65 on Friday to take a four-shot lead into the final round at the PGM Maybank ADT Championship.
Kuala Lumpur, Malaysia, November 29: Atiruj Winaicharoenchai of Thailand is on the brink of securing his first Asian Development Tour (ADT) victory after firing a seven-under-par 65 on Friday to take a four-shot lead into the final round at the PGM Maybank ADT Championship.
Atiruj, nicknamed the Dragon, notched seven birdies in his bogey-free scorecard to reach the 54-hole mark at 15-under-par 201 at the Saujana Golf and Country Club.
Local star Amir impressed with a 68 to give himself another shot at chasing for a maiden ADT victory after coming close with a runner-up finish in Indonesia last year.
Thailand's Sarit Suwannarit settled a further shot back in third following a 69 while compatriot Nirun Sae-ueng takes fourth place on 207.
Shinichi Mizuno of Japan, Suttijet Kooratanapisan of Thailand and Matt Killen of England, who shared the third-round lead with Atiruj, faded away after mustering matching 72s to trail by six shots in fifth position.
"I continued to hit it very well especially my approach shots. I managed to find the green 16 time today and all my seven birdies were within 15 feet," said the 19-year-old Atiruj.
"If I keep playing the way I did today, I believe the victory is within my reach. My goal is to shoot a three-under and hopefully that will be good enough to earn me my breakthrough on the ADT.
"If I can do that, it will be such a good achievement considering I have just turned pro last year. This will stand me in good stead ahead of the Asian Tour Q-School next year where I hope to earn my card," added the young Thai.
Thailand's Suttijet Kooratanapisan shot a solid successive four-under-par 68 to claim a share of the second round clubhouse lead at the PGM Maybank ADT Championship with countryman Atiruj Winaicharoenchai, Shinichi Mizuno of Japan and Matt Killen of England on Thursday.
Kuala Lumpur, Malaysia, November 28: Thailand's Suttijet Kooratanapisan shot a solid successive four-under-par 68 to claim a share of the second round clubhouse lead at the PGM Maybank ADT Championship with countryman Atiruj Winaicharoenchai, Shinichi Mizuno of Japan and Matt Killen of England on Thursday.
Suttijet, a one-time Asian Development Tour (ADT) winner, kept his hopes of winning his first title of the season alive when he traded seven birdies against three bogeys at the Saujana Golf and Country Club.
Joint first round leaders Mizuno, the defending champion and Atiruj both maintained their position atop the leaderboard following matching 70s to share the lead with Killen (68) on an eight-under-par 136 total.
Local hopeful Amir Nazrin (69) was among the three players tied in fourth-place, just one shot adrift. Maybank ambassador Gavin Green, too, gave the home fans something to cheer about as he bounced back with an improved 68 to move to three-way tie for ninth on 139.
The second round of the US$54,000 tournament, which is the second last stop of the 2019 ADT schedule, was halted at 5.34pm local time due to lightning threat. A total of 28 players will return to complete their second round at 7.30am on Friday.
Suttijet is hoping to translate his recent good form into a second victory on the ADT. His sole triumph was at the PGM Palm Resort Championship in 2016.
Prior to this week, Suttijet had performed well in his last two Asian Tour starts, finishing tied 23rd at the Panasonic Open India and tied 12th at the Sabah Masters.
"I love playing in Malaysia. It feels like playing back home, the grass and green is very similar to the golf courses in Thailand.
"It was also in Malaysia three years that I earned my breakthrough on the ADT. Hopefully I'll be able to end my title drought here too," said Suttijet.
Teeing off from the 10th hole, Suttijet made a modest start when he mixed three birdies with two bogeys to turn in 35.
He then stepped up his game, firing four birdies in the next eight holes before a closing bogey prevented him from securing an outright lead.
"I hit my approach shots very well today and gave myself lots of birdie chances which I converted. The course is narrow, hitting a good first shot is equally crucial too.
"The best birdie I had was at the hole 18. My third shot went past the green a little bit, but I made a good chip in there.
"As for the last hole, I didn't hit it as straight as I wanted before the second shot landed in the bunker. I actually recovered well with my shot rolled quite close to the hole, but I missed the putt.
"But that's no big deal. There's still two days left," he said.
The leading seven players on the ADT Order of Merit at the end of the season will earn playing rights on the premier Asian Tour for the 2019 season.
Official World Golf Ranking (OWGR) points are offered for all ADT events. The winner will earn a total of six OWGR points while the top-six players and ties earn points on a sliding scale.
Malaysian ace Gavin Green will lend his star credentials to the PGM Maybank ADT Championship when it gets underway at the Saujana Golf and Country Club on Wednesday.
Kuala Lumpur, Malaysia, November 26: Malaysian ace Gavin Green will lend his star credentials to the PGM Maybank ADT Championship when it gets underway at the Saujana Golf and Country Club on Wednesday.
The 26-year-old, who is the ASEAN ambassador of the Malaysian banking giants Maybank, will make his first Asian Development Tour (ADT) appearance in more than two years when he headlines the US$54,000 tournament, which is the penultimate stop of the season.
Green, who has been mainly competing on the European Tour this season, is thrilled to be playing again in the region's secondary circuit where he had won three times, including being the first amateur winner following his victory in 2014.
Green secured his Asian Tour promotion by finishing second on the ADT Order of Merit in 2016 and his career has gone from strength to strength ever since.
He impressed right away in his debut season, bagging a title and three runner-up finishes to be crowned the 2017 Asian Tour Order of Merit champion.
"It will certainly bring back some good memories, the ADT was where it all started for me after I turned pro in 2015. I'm happy to be able to play this week.
"It's a great circuit and very competitive too," said Green, who has also signed up for next month's Thailand Masters on the Asian Tour as he seeks to end the year on a high.
The world No. 243 Green is also eying the Official World Golf Ranking (OWGR) points at stake in the tournament to boost his position whilst doing his part for Maybank.
"I will certainly not say no to the ranking points.
However, more importantly, this is the Maybank leg of the ADT and it's a good opportunity for me as their ASEAN ambassador to play in this event.
"It will be nice to do well as this will definitely help in preparing for the Maybank Championship next year. I like this (Palm) course and I had a lot of good memories playing here," said Green.
The local contingent also comprises of newly-wed Nicholas Fung and Ben Leong, both winners on the Asian Tour.
They will battle for the US$9,529 top prize with the likes of Japanese duo – current Order of Merit leader Naoki Sekito and last year's champion Shinichi Mizuno, as well as the other top performers of the season such as Thailand's Pannakorn Uthaipas, England's Steve Lewton and American Trevor Simsby.
But all eyes will be on Sekito, who is hoping to edge closer to the Order of Merit victory with yet another strong result.
Sekito was playing catch up in second place to Korea's Joohyung Kim before the latter's made his Asian Tour breakthrough at the Panasonic Open India a fortnight ago. .
Kim, who won his third AT title this season in Pakistan last month to earn playing rights on the Asian Tour for the remainder of the season, secured a one-year winner's exemption on the Asian Tour following his victory.
Having secured his Asian Tour card for 2020, the 17-year-old teen sensation will no longer feature on the ADT Order of Merit as he will not be eligible for any of the remaining ADT events this season.
Sekito, who amassed US$49,827 to date, leads by more than US$20,000 from second-placed Pannakorn (US$29,293).
"I didn't expect to be back on top again! Fortunately my friend Kim earned Asian Tour breakthrough recently and this paved way for me to lead the money list once more, after losing it to Kim earlier on.
"I was so happy for Kim and he inspired me a lot. I've played with him in a lot of tournaments this year and the guy has already won on Asian Tour! I feel like I'm not too far from it too.
"But for now my goal is to win the OOM to secure a better exemption status on Asian Tour next year.
"I know I'm getting close to it and just need solid finish this week. No Japanese has done it before, so I'll be so happy if I can accomplish the goal for my country," said Sekito.
26th November 2019 | Asian Development Tour
Green adds star power at PGM Maybank ADT Championship
By - Tan Ming Wai


Austin Kane is a young man from Madison Maine. He graduated from HS last year and in December he started basic training at Lackland Air Force Base in San Antonia,TX. Within a short time of being there, he had flu like symptoms and went to the base clinic. Because of his symptoms, the base doctor ran more tests on him. He soon received the scary news that he had Hodgkins Lymphoma stage 2-A. Imagine getting this news and being all alone, so far from home. His mother and grandmother are now with him, but he is still so far away from his family and support system. Austin's treatments will take about 4-6 months to complete and he will be having his treatments right in Texas.
We would like to create that same feeling for this young man and his mom, who are fighting this battle so far from home. No one fights alone and I hope with your help we can show this family we all are thinking and praying for them.
JUST ONE word or one phrase of encouragement and one dollar.


LNG stands for Liquefied Natural Gas.
Natural gas is a natural fossil fuel also referred to as the "blue fuel".
The extraction of natural gas, production of LNG, transportation, regasification and distribution entail the use of a range of technologies within the LNG supply chain.
LNG vessels are also referred to as methane carriers. They represent the latest and most technologically advanced ships worldwide.
Increasing demand for natural gas all around the world and the limits of throughput of onshore and offshore pipelines result in the increase in the number of LNG terminals.
How the LNG is Stored?
Liquefied natural gas may be stored in both stationary and mobile containers.
It is a process in which liquefied natural gas is heated and turned back into gas.
Increasing interest in LNG has been recorded in the seventies and eighties of the twentieth century when technologies of liquefaction and long-haul transportation became widespread.


text:
import React from 'react';
import TextField from '@material-ui/core/TextField';
import { makeStyles } from '@material-ui/core/styles';

const useStyles = makeStyles((theme) => ({
  root: {
    '& .MuiTextField-root': {
      margin: theme.spacing(1),
      width: 200,
    },
  },
}));

export default function ValidationTextFields() {
  const classes = useStyles();

  return (
    <form className={classes.root} noValidate autoComplete="off">

        <TextField error id="standard-error" label="Error" defaultValue="Hello World" />
        <TextField
          error
          id="standard-error-helper-text"
          label="Error"
          defaultValue="Hello World"
          helperText="Incorrect entry."
        />

        <TextField
          error
          id="filled-error"
          label="Error"
          defaultValue="Hello World"
          variant="filled"
        />
        <TextField
          error
          id="filled-error-helper-text"
          label="Error"
          defaultValue="Hello World"
          helperText="Incorrect entry."
          variant="filled"
        />

        <TextField
          error
          id="outlined-error"
          label="Error"
          defaultValue="Hello World"
          variant="outlined"
        />
        <TextField
          error
          id="outlined-error-helper-text"
          label="Error"
          defaultValue="Hello World"
          helperText="Incorrect entry."
          variant="outlined"
        />

    </form>
  );
}

redpajama_set_name: RedPajamaGithub


Who Wore It Better? Krystal, Amber, or Seungri?
The shirt that all three of them are wearing is from the brand "Misfits" and is the "Glow In The Dark Two Fiend Skull Men's T-Shirt". While Amber and Krystal wore this shirt during their "Electric Shock" live performances, Seungri wore his during their Big Bang Naver countdown on August 4th.


I found this again! Seriously one of my favorite songs on here.
Can I get this track without the drums ?
Wow! I just noticed there's cripta in this!!! !!! Still my favorite!
This showed up on the list of new tracks for some reason. Took the opportunity to relisten and refave!


text:
Iryanthera juruensis is a species of tree in the Myristaceae family. It is native to Panama and South America.

References

Trees of Peru
Myristicaceae

redpajama_set_name: RedPajamaWikipedia


text:
Support for Interboro High School Treasurer
0 have signed. Let's get to 1,000!
At 1,000 signatures, this petition is more likely to be featured in recommendations!
Anonymous Anonymous started this petition to Organizer of "Interboro High School Treasurer is a Racist!" and Interboro School District/Borough
On Saturday, August 1, 2020, there was a scheduled protest for "Black Lives Matter". Rumors swirled about BLM bringing in outside organizers, from cities like Detroit & DC, and with the nation-wide looting and violence during such protests, as well as the disgusting treatment of our brave men and women of Law Enforcement; Delaware County Residents organized an event to support our Law Enforcement Officers, as well as make sure no looting or rioting took place in our hometown.
There is currently a petition on change.org titled "Interboro High School Treasurer is a Racist!". The accused 'racist' is Christine Alonso, an American Hero who served and fought for America in the Army out in Iraq in the early 2000's.
After reviewing every piece of video evidence, as well as speaking with people from both BLM and Back the Blu who were present, there seems to be absolutely no evidence of Christine using any racial slurs whatsoever.
This is a clear case of defamation of character, based on fake news spreading on Facebook and other outlets. It is even more upsetting, that BLM has disrespected our Law Enforcement, but now are also defaming the character of a Veteran who was wounded in action while fighting for our freedom's as Americans!
Please join our community in signing this petition, in hopes of
a.) removing the petition "Interboro High School Treasurer is a Racist!" from the website: change.org, due to a violation of policy,
b.)bringing this signed petition to the Interboro School Board's attention, in defense of the innocent Christine Alonso.
I sincerely thank all of the locals, and non-locals, for signing this petition for doing what is right by standing up to the mob.

redpajama_set_name: RedPajamaCommonCrawl


Gated community with 2 car garage! Nice condo located in Brookhaven Circle. Conveniently located near shopping. Two car garage is a huge plus as well as a separate laundry room in unit with new flooring that has lots of space & storage. Freshly painted ready for a new buyer. Two bedrooms are good size with ample closets and this condo has 2 full bathrooms too. Vaulted ceiling in master bedroom and family room. Top floor unit with large deck with new floor. Tranquil community offers a pool and spa and the grounds are kept up beautifully. Excellent central area of Garden Grove. See it today and make an offer!


How long does it take to learn to drive a semi-truck ... safely?
There are no national standards for training new semi-truck drivers.
Several years ago, I represented Angelah, a young girl with a mild traumatic brain injury.
She had been in a terrible crash.
Her mother was driving. The afternoon was rainy, and the road was wet.
A truck driver failed to take into consideration roadway hazards and struck the family vehicle.
He hadn't been driving a semi-truck for very long—he was still in training. He wasn't driving carefully, especially for the weather conditions.
If that young trucker had more experience, he might not have made this tragic decision. He might have slowed down.
I don't think that the semi-truck driver meant to cause a crash.
I don't think he climbed into the cab that day thinking his driving could cause a child's serious head injury.
I don't think he would make the same bad driving decisions if he could live that day all over again.
I do think it's likely that this crash had a negative impact on his life, as it did on Angelah's life.
And I think that more training would have improved his driving skills.
New truckers and trainees are statistically far more likely to be involved in a collision.
Yet, there are no national standards for training new semi-truck drivers before they hit the road.
In March 2016, FMCSA proposed a national standard for trucker training, a rule that would require 30 hours of training for a Class A commercial license. That's the license for drivers operating tractor-trailers over 26,000 pounds … like the truck in Angelah's devastating crash.
The proposed rule would include a minimum of 10 hours operating a tractor-trailer on a practice driving range.
30 hours of training is not an onerous standard.
This issue isn't especially contentious.
Even the Owner-Operator Independent Driver's Association (OOIDA), an organization known for opposing federal mandates for trucking, cites driver training as a shared top priority with the federal agency.
In Angelah's case, the trucking company eventually offered to settle her brain injury claim. It was a fair settlement, one that has allowed her to get the ongoing care she needs.
The final rule on national trucker training standards is expected by the end of 2016.


To kick off SIGGRAPH 2018, Allegorithmic will host Substance Day SIGGRAPH on August 13, featuring a keynote speech from founder and CEO Sébastien Deguy showcasing the upcoming AI-powered tool, Alchemist.
It all begins with the first-ever Project Alchemist live demo, followed by a full day of talks offering practical tips for users while highlighting the impact of the Substance tools across multiple industries. The event will then conclude with a casual mixer open to all attendees.
Both the keynote address and the reveal of the contest winners will be livestreamed on the Allegorithmic YouTube channel. A complete schedule of the day's events can be found here.
Substance Day SIGGRAPH is the latest in a series of successful community events created to bring Substance users together with industry professionals and the teams that created the Substance tools. This latest event follows Substance Days Asia, Substance Day London and Substance Day GDC, which featured standing room only crowds. Following SIGGRAPH, the next Substance Days will take place in Los Angeles in the Fall, and then Paris soon after.
After Substance Day SIGGRAPH, Allegorithmic will appear as part of NVIDIA's Limelight 2018 event on August 14 from 6:30 p.m. to 9:30 p.m. PDT at the Hyatt Regency. There it will showcase its latest releases, including the recent Substance Painter and Substance Designer Summer updates. Then on August 15 at 6:30 p.m. PDT at The Portside Pub, Allegorithmic will co-sponsor "SIGGIES," an event hosted by The Rookies, created to bring together students and industry professionals.
Allegorithmic will also be exhibiting during SIGGRAPH on the show floor, with demonstrations taking place at booth #415. To schedule a meeting, please contact: events@allegorithmic.com.


Your look is all about surprises, so we updated our Classic Leather with a pop of eye-catching cork. Subtle and stylish, this shoe comes in neutral colors that compliment any outfit. Plus, the fresh white sole keeps this look on point from day to night.


Buying A Rent To Own Home In Springfield Can Be Easy.
We'd love to help you get into one of our Springfield Rent To Own Homes / Lease Purchase Homes. Bad or NO credit isn't a problem with us.
Want to Buy A Springfield Home?
You've found the right place for a fantastic Springfield home.
Give us a call anytime at (417) 942-4289 to find out how we can help you, or fill out the form below to get started now.
Fill out the form BELOW to get the process rolling and see available Rent to Own Houses in Springfield!


The property is set within the gated community of Sotogrande in Costa del Sol, Spain. Our luxury villa is close to the Valderrama and La Reserva golf courses, the tennis clubs, riding centre and Sotogrande Port and many superb restaurants for eating out.
The property features air-conditioning, under floor heating, designer kitchen, a private swimming pool and includes satellite TV, 3 flat screen and one conventional TV, computer, WIFI Internet access, PlayStation 3, pool / snooker table, hi-fi with iPod & iPad dock and DVD player.
PLEASE NOTE: Special rental rates available for January, February and March 2013 for bookings of 2 weeks and longer.
Sport & Leisure: Sotogrande has a wealth of sport and leisure facilities at hand; golf, tennis, equestrian, sailing and fishing.
Boats can be chartered and fishing trips arranged at the marinas at Sotogrande and Duquesa.
There is a Spa at the Almenara Hotel which is a 5 minute drive from the villa.
Club de Pádel y tenis.


text:
package im.tox.upsourcebot.client.tasks;

import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import javax.annotation.Nullable;

/**
 * Class for retrying actions with different retry strategies
 */
public class RetryingCallable<E extends Exception, V> implements RecoveringCallable<E, V> {

  private static final Logger LOGGER = LoggerFactory.getLogger(RetryingCallable.class);
  private static final int SLOT_TIME = 5000;
  private static final int CEILING = 16;

  private RecoveringCallable<E, V> callable;

  private BackoffStrategy backoffStrategy;

  public RetryingCallable(RecoveringCallable<E, V> callable, BackoffStrategy backoffStrategy) {
    this.callable = callable;
    this.backoffStrategy = backoffStrategy;
  }

  /**
   * Static helper method to create a RetryingCallable without a lot of Generic parameters
   */
  public static <E extends Exception, V> RetryingCallable<E, V> of(
      RecoveringCallable<E, V> recoveringCallable) {
    return new RetryingCallable<>(recoveringCallable, getDefaultBackoffStrategy());
  }

  /**
   * Try to execute the callable.
   *
   * @throws InterruptedException if the containing thread is interrupted
   * @throws E                    if the execution failed after the strategy depleted its retries
   */
  @Nullable
  @Override
  public V call() throws E, InterruptedException {
    Exception previousException = null;
    for (; backoffStrategy.retryAgain(); backoffStrategy.tryComplete()) {
      try {
        return callable.call();
      } catch (InterruptedException e) {
        throw e;
      } catch (Exception e) {
        LOGGER
            .error("Execution of task failed, retrying in " + backoffStrategy.waitTime() + "ms", e);
        previousException = e;
        Thread.sleep(backoffStrategy.waitTime());
      }
    }
    if (previousException instanceof RuntimeException) {
      throw (RuntimeException) previousException;
    } else {
      throw (E) previousException;
    }
  }

  private static BackoffStrategy getDefaultBackoffStrategy() {
    return new ExponentialBackoffStrategy(SLOT_TIME, CEILING);
  }

}


Ophthalmology: Researchers describe a syndrome of chronic intracranial hypotension due to ventriculoperitoneal shunt for pseudotumor which works too well. They describe four patients who develop cosmetically obvious enophthalmos, sometimes to such a degree that the lids cannot wipe the eyes normally and they develop blindness due to exposure keratopathy. The low ICP allows the orbit to expand with no fat atrophy, and CT reveal shortened, straight optic nerves. Interesting and rare. If the shunt cannot be revised, the authors wonder if surgical olume replacement may be of benefit.


it and a reduced test case in the debian bug tracker.
OK, I tested with gcc-4.4 since gcc-4.4.2-3 does not contain the patch for PR/42113, whereas gcc-4.4.2-4 does.
Verified that the two debian source packages, libssh2 and mpich2, when compiled with gcc-4.4.2-3 both generate ICEs of the nature shown above.
Compilation with gcc-4.4.2-4 of these two packages is successful (well, I didn't let mpich2 go to completion but it got well past the point where the ICE was generated with gcc-4.4.2-3).
So looks like this bug is indeed PR/42113 and is fixed in current unstable gcc-4.4.
What is the timeframe for getting the Alpha buildds updated to a fixed version of gcc?


text:
Rival emerges as new suitor for Dallas-based data center operator CyrusOne
The company began exploring options with advisers this summer after receiving takeover interest.
CyrusOne's new $600 million data center has opened in Allen.(Steve Brown)
By Bloomberg Wire
5:55 PM on Sep 20, 2019 CDT
New suitors have emerged for Dallas-based CyrusOne Inc., the data-center company exploring a sale.
The real estate investment trust has drawn interest from rival Digital Realty Trust Inc., according to people familiar with the matter. The investment firms EQT Partners and Digital Colony Partners have also partnered to pursue a potential deal for the company, said the people, who asked to not be identified because the matter isn't public.
Discussions are ongoing and may not lead to a deal, the people said.
CyrusOne, which began exploring options with advisers this summer after receiving takeover interest, closed up 1.8% Friday Thursday, for a market value of $8.78 billion. The shares have gained more than 50% this year.
Representatives for Digital Colony, Digital Realty and EQT declined to comment. Representatives for CyrusOne didn't immediately respond to requests for comment.
A bidder group including KKR & Co., Stonepeak Infrastructure Partners and I Squared Capital was also considering an offer for CyrusOne, Bloomberg reported last month.
Demand for data center assets has intensified as infrastructure managers flush with cash look to capitalize on the trend of companies relying on third parties for managing their data. REITS that specialize in data centers have also been seeking to expand globally through acquisitions.
Founded in 2001, CyrusOne has a network of 48 data centers serving about 1,000 customers in the U.S., the U.K., Singapore and Germany, according to its most recent annual report. It has grown from $330.9 million in revenue in 2014 to $821.4 million last year.
Digital Colony is a communications infrastructure-focused investment firm and EQT is one of the largest buyout firms in Europe. In May, they partnered to buy fiber network owner Zayo Group Holdings Inc. for more than $8 billion.
Digital Realty, like CyrusOne, is a REIT focused on data centers. Last year, it acquired Brazil's Ascenty for about $1.8 billion.
Brookfield, among the world's largest alternative-asset managers, has also been increasing its technology-related infrastructure bets, buying a portfolio of data centers from AT&T Inc. last year for $1.1 billion.
Nabila Ahmed and Gillian Tan, Bloomberg
Bloomberg Wire
newsfeedback+wireservices@dallasnews.com
Dozens gather outside Dallas police headquarters following Tyre Nichols video release


text:
Microsoft names Christopher Young to lead business development
REDMOND, Wash., Nov. 11, 2020 /PRNewswire/ — Microsoft Corp. on Wednesday named Christopher Young as executive vice president of business development. Young will report directly to Microsoft Chief Executive Officer Satya Nadella.
A respected voice in technology and cybersecurity, Young most recently served as chief executive officer of McAfee, one of the largest cybersecurity companies in the world. In 2017, Young led the initiative to spin McAfee out of Intel as a standalone company and has since spearheaded McAfee's mission to protect systems and data of customers around the globe. Previously, Young held senior leadership positions at Cisco, VMware, RSA and AOL.
"I've known Chris for many years and have admired his accomplishments as a leader. His experience and skills are an invaluable addition to our company and the senior leadership team," Nadella said. "We know that for our customers and partners, the next decade of economic growth will be defined by the digital investments made today. With Chris' leadership, the Business Development team will continue to be a key accelerant for our partnerships and new growth opportunities."
Young will be responsible for developing Microsoft's global business development strategies that drive growth across the company. This includes leading the evaluation and execution of strategic partnership opportunities, including alliances, venture investments and joint ventures that align with corporate strategy.
"The pace of change in our world is accelerating, and technology-driven experiences that are more connected, interactive and intelligent are the drivers," Young said. "It is great to be joining Microsoft, to help lead this transformation in the way we work and live."
Young holds an A.B. from Princeton University and an MBA from the Harvard Business School. He serves as a member of the President's National Security Telecommunications Advisory Committee (NSTAC) and sits on the boards of directors of American Express and Snap Inc.
Microsoft (Nasdaq "MSFT" @microsoft) enables digital transformation for the era of an intelligent cloud and an intelligent edge. Its mission is to empower every person and every organization on the planet to achieve more.
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Fox takes care of its own: the full-court defense of O'Reilly's 9-11 remarks
Written by Sean Easter
Since Bill O'Reilly appeared on the ABC's The View and said "Muslims killed us on 9-11," Fox News hosts and commentators have predictably defended the Fox News host. O'Reilly has also used his Fox News platform to defend his comments.
O'Reilly on The View: "Muslims killed us on 9-11"
Comments prompted walkoff by Goldberg, Behar. During an appearance on the October 14 edition of ABC's The View, O'Reilly discussed the planned Islamic cultural center near the site of Ground Zero in New York. Asked by co-host Whoopi Goldberg why building the center there was "inappropriate," O'Reilly responded, "Because Muslims killed us on 9-11." The remark prompted Goldberg and co-host Joy Behar to walk off the set. O'Reilly later said, "If anybody felt I was demeaning all Muslims, I apologize."
Fox hosts, commentators rush to O'Reilly's defense
Kilmeade: "Not all Muslims are terrorists, but all terrorists are Muslim." On the October 15 edition of Fox & Friends, host Brian Kilmeade said of the hosts on The View: "That was our debate seven weeks ago, and they can't handle the give and take of a debate." Kilmeade added, "Not all Muslims are terrorists, but all terrorists are Muslim."
Rove defends O'Reilly: "There is an insensitivity on the left and an attitude toward civil discussion where you can't have it toward a conservative." On Fox & Friends, guest Karl Rove said, "There's an insensitivity on the left, and there's an attitude toward civil discussion that you can't have it with a conservative. You have a conservative viewpoint, it has to be dismissed, it has to be discredited." Later in the segment, Rove said, "Bill had won the debate the moment Joy Behar got up and walked off."
Carlson decries "not that friendly" body language, claims media double standard. Fox & Friends co-host Gretchen Carlson introduced the O'Reilly segment by saying that "the body language with the ladies the minute he sat down was not that friendly." Later in the segment, Carlson asked phone guest O'Reilly, "She didn't leave, but let's turn the tables here for a minute. What if President Obama had been on that show, or any other high-level Democrat, and he had gotten into a screaming match with [View co-host] Elizabeth Hasselbeck and she had gotten up and left. She would have been fired probably, right?"
O'Reilly on Fox & Friends: "[T]he left wing in America will not come to grips with the fact that there is a problem in the Muslim world." O'Reilly talked to Fox & Friends via phone to discuss his experience on The View. He began by criticizing an appearance by Fox News host Geraldo Rivera earlier on Fox & Friends, in which he likened terrorists to abortion clinic bombers, as representative of "the liberal point of view." From the show:
O'REILLY: I guess, you know, I'm a little discouraged with the liberal point of view as espoused by Geraldo just a few minutes ago on Fox & Friends. I mean, you know, I'm a little bit tired of this, that somehow the left wing in America will not come to grips with the fact that there is a problem in the Muslim world.
CARLSON: Yep.
O'REILLY: It's a problem. All right? We're fighting them in Afghanistan, fighting them in Iraq. We might fight them in Iran. They cause trouble, they being Muslim extremists all over the world. But after 10 years, I think any intelligent person knew what I was talking about in that mosque debate. But they wanted -- they want, all right, they being the far left, I would say -- but even Geraldo, they want you to be politically correct in defining a life-death struggle, and I'm just not going to do it anymore.
O'Reilly on Beck: "I just told the truth that Muslims attacked us on 9-11." O'Reilly appeared on the October 14 edition of Fox News' Glenn Beck to defend his comments:
BECK: Bill, while I disagree with your reasoning on the mosque, on why you don't think it should be built there, what happened?
O'REILLY: I don't know. I mean, I just told the truth that Muslims attacked us on 9-11, and I guess I wasn't sensitive enough for Miss Behar or Miss Goldberg, and I apologize for not being sensitive enough. But I think after almost 10 years we all got that it was Muslim extremists. As I say on the Factor tonight, when we're talking about World War II, do we say we were attacked by Japanese extremists? No, we talk about the Japanese attacked us. Not every Japanese, but that was the group. And so the group that attacked us were Muslims.
O'Reilly also said, "The Muslims who attacked us on 9-11 are part of the jihad, which is a movement, and the movement has not been confronted by the so-called 'moderate' Muslims, good Muslims. They haven't confronted the jihad," and added, "If all of the moderate Muslims throughout the world would confront the jihad, the jihad couldn't exist. The jihad exists because governments let the jihad exist."
O'Reilly: Polls show "most Muslims don't believe 9/11 was even committed by al-Qaeda." O'Reilly later said on Glenn Beck, "The truth that many liberal Americans don't want to acknowledge is if you look at every opinion poll in the Muslim world, most Muslims don't believe 9-11 was even committed by Al Qaeda, OK? They have a very low favorability of America, even with Barack Obama in charge. There is a tension between the Muslim world and America."
Beck says View walk-off teaches "so much about the left and their willingness to have a conversation and tolerate other people's opinion." During the appearance, Beck suggested that a guest calling tea-party members racist would not prompt a similar walk-off:
BECK: Do you think if they would have had, let's say, Michael Moore on -- and not to compare you to Michael Moore, and I apologize to you. But if you would have had Michael Moore on and he said, "These tea party people, they are all terrorists," do you think any of them would have gotten up or even gotten heated at that?
O'REILLY: No, I don't believe anybody would have walked off if Michael Moore said that tea party people are racist. But look, the big issue that I want your audience, in case they didn't see the program today, was that I was saying there is a gulf between the president and many Americans and that's hurting him in the polls about the economy. And the gulf is that when he was asked about the wisdom of the 9-11 mosque, he wouldn't answer the question. And most Americans, according to the CNN poll, which I cited, agree with me, that it's inappropriate place to put a mosque because of what happened on 9-11.
BECK: I agree with you.
At the end of the interview, Beck said, "You watch the whole - I mean, it's amazing. You will learn so much about the left and their willingness to have a conversation and tolerate other people's opinion."
O'Reilly guest Ingraham: "They're treating you like Mahmoud Ahmadinejad at the U.N. ... This is an attempt to shut down political speech." Discussing the incident on the October 14 edition of The O'Reilly Factor. Fox News contributor Laura Ingraham called The View walk-off "an attempt to intimidate others" and a "sideshow" :
INGRAHAM: But what they're doing -- I just want to be very clear so people listening understand what's going on. What they did today was an attempt to intimidate others. They know they're not going to intimidate you, but it's really -- it's very disturbing to me because people who say that they're for free speech, and Barbara Walters usually does a pretty good job of moderating that -- I mean, to come back and say that you are the pinhead after they embarrassed themselves walking off their own set, that was embarrassing. They're treating you like Mahmoud Ahmadinejad at the U.N., and you're a lot taller than Mahmoud, Bill. So, I mean, it's ridiculous. This is an attempt to shut down political speech.
O'REILLY: But I didn't take offense at Ms. Walters. I have to say I didn't take offense at Barbara's --
INGRAHAM: Well, you should have. You are not a pinhead. Well, sometimes you are a pinhead, but not this time.
O'REILLY: She sees it -- sincerely sees it that if you say Muslims attacked America on 9-11 --
INGRAHAM: That's ridiculous.
O'REILLY: -- you are somehow denigrating an entire people. I don't see it that way. It's as simple as that. I will give you the last word.
INGRAHAM: Bill -- Bill, here's what's -- here's what's really happening is that I think a lot of the gals on The View, they're kind of freaking out, right? Because the hope-and-change thing and Obama and insignia and the star power and all the celebrities and all the Hollywood people who loved him, all of that has resulted in anemic approval numbers and Republican conservative Tea Party resurgence.
O'REILLY: All right.
INGRAHAM: And they don't know what to do. So they're trying to, you know, create these sideshows, and I think you did just fine.
Tantaros: View walk-off was liberal "schtick." In an appearance on the October 14 edition of America Live, Fox News contributor Andrea Tantaros said:
TANTAROS: Well, if they were trying to convince anybody of their point, I think that they failed. And the message was, the show is called The View for one reason and not The Views. They tolerate only one point of view, and that's their point of view. And look, O'Reilly came on the show armed with facts. He was arguing from a position of strength, he had numbers to back it up, and he was stating his point of view, and they just did not have the facts to back it up. And so they stormed off the set -- I mean, this is their schtick, this is what liberals do: "We don't agree with you, we're getting off the set. And Megyn, they're not used to having anybody challenge them. To have O'Reilly come on the show and actually challenge them, I mean, wow, they just couldn't take it anymore.
Laura Ingraham says elementary school is "demonizing all people who are non-minority"
Laura Ingraham: "The American left has proven itself to be dangerous"


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Teasers for A&E's Bates Motel are creepy and short, so you should definitely watch them
Jamie Frevele 1:14 pm Fri Nov 30, 2012
(Video link) Well, color me optimistic. I really wasn't sure about A&E making a "prequel show" to Alfred Hitchcock's Psycho, but now I'm wondering if it's better to keep an open mind. Because these two teaser trailers are delightfully spooky, with tiny, amuse-bouche amounts of suspense packed into about 15 seconds each. Enough to pique my interest, at least, but I'll let you decide for yourself. The second teaser is after the jump.
Teaser #2 (video link):
Feels the tiniest bit like both teasers are trying to capture the attention of the American Horror Story audience, but I'll cop to being interested in the story of the young Norman Bates (Freddie Highmore) and Mother (Vera Farmiga). I mean, what happened to that kid, anyway?
(via Bleeding Cool)
teaser trailers
Why has fandom become so toxic?
It's getting difficult to like anything. Or rather, it's getting difficult to be a vocal fan of anything. In recent years, every aspect of entertainment has become as polarized as our political discourse. With warring encampments of fans waging flame wars on Reddit and Twitter, declaring yourself an admirer of something—usually science fiction—is tantamount to… READ THE REST
Watch a pro wrestling event spark a real-life riot
I walked into my pro wrestling fandom without any illusions of legitimacy about the "sport." I didn't become a wrestling fan until I reached the world-weary age of 13. So much of wrestling's cartoony presentation in the late 80s and early 90s kept me at arm's length, and it wasn't until the product garbed itself… READ THE REST
Wanda and Jamal are getting a Netflix movie called The Thanksgiving Text
Six years ago, Wanda Dench accidentally sent a Thanksgiving invite to seventeen-year-old Jamal Hinton, thinking it was her grandchild. Jamal pointed out the mistake but asked to join anyway, and Wanda agreed, saying "that's what grandmas do… feed everyone!" The pair met up for the holiday and the story, for one reason or another, went… READ THE REST
Save 85% on a Lifetime License to Microsoft Office Home & Business for Mac
We thank our sponsor for making this content possible; it is not written by the editorial staff nor does it necessarily reflect its views. Tax season begins soon, and like years before, many consumers are gearing up to use their tax returns to buy the latest tech. For example, tech lovers have a reason to… READ THE REST
Working outside the office just got way easier, thanks to this portable 4K touchscreen monitor
We thank our sponsor for making this content possible; it is not written by the editorial staff nor does it necessarily reflect its views. You do a lot on that little laptop of yours, from (reluctantly) answering work emails to shopping for a new ride. But with all these digital tasks come many annoying roadblocks,… READ THE REST
Your cat will have a ball with new self-moving teaser ball for only $29
We thank our sponsor for making this content possible; it is not written by the editorial staff nor does it necessarily reflect its views. If you've got a fuzzy feline friend at home, you know how important it is to keep them active and stimulate their curiosity. They can get bored quickly of stationary toys, and… READ THE REST


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Effects of renal denervation on cardiac oxidative stress and local activity of the sympathetic nervous system and renin-angiotensin system in acute myocardial infracted dogs
Qiaoli Feng1,
Chengzhi Lu2,
Li Wang2,
Lijun Song3,
Chao Li2 &
Ravi Chandra Uppada1
This study sought to evaluate the therapeutic effects of renal denervation (RDN) on acute myocardial infarction (MI) in canines and explore its possible mechanisms of action.
Eighteen healthy mongrel dogs were randomly assigned to either the control group, the MI group or the MI + RDN group. To assess cardiac function, left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded. Additionally, haemodynamic parameters such as left ventricular systolic pressure (LVSP), left ventricular end-diastolic pressure (LVEDP) and heart rate (HR) were measured. Cardiac oxidative stress levels were evaluated based on the expression of p47phox mRNA, malondialdehyde (MDA), anti-superoxide anion free radical (ASAFR) and activity of superoxide dismutase (SOD). To measure the local activity of the sympathetic nervous system (SNS) and renin-angiotensin system (RAS), the levels of tyrosine hydroxylase (TH), angiotensin II (AngII), angiotensin-converting enzyme 2 (ACE2), angiotensin (1–7) [Ang(1–7)] and Mas receptor (MasR) in myocardial tissues were recorded. The expression of TH in renal tissue and serum creatinine were used to assess the effectiveness of the RDN procedure and renal function, respectively.
We found that MI deteriorated heart function and activated cardiac oxidative stress and the local neurohumoral system, while RDN partially reversed these changes. Compared with the control group, parameters including LVEDD, LVESD, LVEDP and the levels of ASAFR, MDA, p47phox,ACE2, Ang(1–7), MasR, AngII and TH-positive nerves were increased (all P < 0.05) in myocardial infracted dogs; meanwhile, LVEF, FS, LVSP and SOD expression were decreased (all P < 0.05). However, after RDN therapy, these changes were significantly improved (P < 0.05), except that there were no significant differences observed in FS or LVSP between the two groups (P = 0.092 and 0.931, respectively). Importantly, the expression of TH, AngII and Ang(1–7) was positively correlated with MDA and negatively correlated with SOD. Between-group comparisons demonstrated no differences in serum creatinine (P = 0.706).
RDN attenuated cardiac remodelling and improved heart function by decreasing the level of cardiac oxidative stress and the local activity of the SNS and RAS in cardiac tissues. Additionally, the safety of the RDN procedure was established, as no significant decrease in LVSP or rise in serum creatinine was observed in our study.
The incidence of acute myocardial infarction (MI) has increased over time. Chronic heart failure (CHF) is a common complication of acute MI, which places substantial burden on the health care system. Complicated pathophysiologic mechanisms participate in the development of HF, among which the whole-body and local cardiac sympathetic nervous system (SNS) and renin-angiotensin system (RAS) contribute significantly to the pathogenesis of CHF. Recently, oxidative stress has been demonstrated to play a pivotal role in ventricular remodelling after MI. In the clinical setting, drugs targeting these two systems, such as angiotensin-converting enzyme inhibitors(ACEI), angiotensin receptor blockers(ARB), mineralocorticoid receptor antagonists, and beta-blockers, have been the mainstay of management for post-MI HF. Additionally, anti-oxidative therapy has attracted increasing attention in the cardiovascular field. However, despite intensive therapeutic treatment, a large number of patients continue to experience worsening of HF symptoms. Thus, it remains necessary to explore new therapeutic approaches for the treatment of MI and its complications.
Previously published studies have shown that renal denervation (RDN) provides significant benefits in delaying the progression of cardiac hypertrophy [1], attenuating left ventricular (LV) remodelling and improving cardiac function [2]. The activities of the systemic SNS and RAS [3, 4] were shown to be decreased by RDN through interruption of the renal sympathetic efferent and afferent nerves [5]. However, the effects of RDN on cardiac-specific SNS and RAS activity and oxidative stress have not been investigated. In the present study, we used an established canine MI model to explore the related mechanisms, and thus further validate that RDN could be used as a new treatment for post-MI remodelling and HF.
Eighteen healthy mongrel dogs (male:female, 8:10), weighing 15 ~ 18 kg, were used in this study (and were provided by the Experimental Animal Centre in Tianjin). The experiments were carried out in strict accordance with the guide for the care and use of laboratory animals. The animals were kept under a 12/12-h light/dark cycle and fed with regular chow and water ad libitum.
Experimental groups and conditions
All experimental mongrel canines were randomly divided into three groups. (1) The control group (n = 6) received only a coronary angiogram, followed by a renal arteriogram one week later. (2) The MI group (n = 6) underwent an established procedure inducing MI and, one week later, underwent a renal arteriogram. (3) The MI + RDN group (n = 6) underwent the MI-inducing procedure, followed by renal denervation one week later.
All animals were anesthetized with 6% sodium pentobarbital (30 mg/kg, intravenous (IV)), with an additional 50 mg given as needed through IV injection every 30 to 60 min, according to the reaction of the animals. The dogs were placed on the operating table in a supine position. Using a Mac-Lab (GE, United States) hemodynamic detection system, electrocardiography (ECG) and vital signs were monitored. The right iliac region was shaved and disinfected, and then a venous pathway was established. The right femoral artery was punctured, and then a 6 F guiding wire was inserted through the sheath, followed by the injection of 1000 IU heparin. After verifying the coronary anatomy, a bolus of gelatine sponge (1 mm in diameter) was injected into the distal end of the fist diagonal branch of the left anterior descending artery, as described previously [6]. Coronary angiography was performed again 10 min later to confirm interruption of the blood flow in the distal vessels. The operation lasted 60–90 min.
Renal denervation
Under pentobarbital sodium (30 mg/kg, IV) anaesthesia, bilateral renal denervation was performed in the MI + RDN group; meanwhile, in the control and MI groups, the operation was the same except that the nerves were kept intact. The right femoral groin was shaved prior to connecting the radio frequency ablation apparatus (IBI-1500 T, IBI, United States). The temperature of the radiofrequency ablation instrument was set at 43 °C, at a power of 10 W, for a duration of 90 s. The right femoral artery was punctured, and a 6 F guiding wire was inserted through the guiding sheath. Renal angiography was performed to determine the location of the renal artery. The ablation electrode (6 F ablation catheter tip, electrode length of 4 mm) was then inserted, and radio frequency (RF) energy was applied to the endothelial lining. The catheter tip was placed in the proximal portion of the renal artery main trunk, and the ablation procedure was conducted by applying RF energy in the renal artery distally to proximally and circumferentially. Then, the catheter was withdrawn 1–2 cm to generate another ablation location. Renal angiography was performed again to validate that the catheter tip was well-attached to the vessel wall before ablating at the new target site. This procedure was repeated three to four times in the renal artery, and then the same RF energy was applied to the contralateral renal artery.
Transthoracic echocardiography
To evaluate LV function and cardiac chamber structure, echocardiography was performed at baseline and 4 weeks after MI (CX50, Philips, Netherlands). Parameters such as the left ventricular ejection fraction (LVEF), left ventricular end-diastolic dimension (LVEDD), left ventricular end-systolic dimension (LVESD) and fraction shortening (FS) were recorded. LVEF was measured using X-plane imaging and was calculated as follows: (LVVmax- LVVmin)/LVVmax. Three consecutive cardiac cycles were observed, and the average values were recorded as the final cardiac parameters.
Detection of haemodynamics
Haemodynamic parameters were detected at baseline and at 4 weeks post-MI. The right femoral artery was punctured, and a 6 F pigtail catheter was used to perform LV angiography. The heart rate (HR), left ventricular systolic pressure (LVSP), and left ventricular end-diastolic pressure (LVEDP) of each animal were measured using the Mac-Lab system.
Enzyme-linked immunosorbent assay (ELISA)
The myocardial expression of AngII and Ang(1–7) were detected using a commercial ELISA kit (Huamei Biological Co., Wuhan, China). The reaction system and standard curves were established according to the kit's instructions.
Real-time reverse transcription polymerase chain reaction (RT-PCR)
We used RT-PCR analysis to assay the mRNA expression of angiotensin-converting enzyme 2 (ACE2) and MasR in the LV. Total RNA extraction was performed according to the instructions provided with the Trizol reagent (CWbio. Co. Ltd, Cat# CW0581). Template cDNA was prepared from total RNA using the HiFi-MMLV cDNA reverse transcription kit (CWbio. Co. Ltd, Cat# CW0744). Quantitative PCR (Q-PCR), using an ABI7500 (Applied Biosystems, United States), was performed in triplicate for the amplification of target genes, while GAPDH was selected as an endogenous control. Each sample was run in duplicate with the following thermocycler protocol: an initial step 95 °C for 10 min, followed by 45 cycles at 95 °C for 15 s and 60 °C for 30 s. The PCR mix contained 0.4 uL (10 μmol) of forward and reverse primers, 10 uL of 2× UltraSYBR Mixture (CWbio. Co. Ltd, Cat# CW 0956), 2 uL of template cDNA and RNase-free water to a final volume of 20 uL. Melting curve analysis was used to confirm the specificity and identify of the PCR products, and relative gene expression changes were measured using the delta-delta Ct method, where X = 2-ΔΔCt. The primer sequences used are listed below in Table 1.
Table 1 Specific primers for Q-PCR
Immunohistochemistry analysis
Cardiac expression of TH was detected by immunohistochemistry. Myocardial tissues were fixed with formalin, and after embedding and dehydrating, the LV tissue was sliced into 4-um sections. The sections were treated for 10 min with 1% methyl alcohol in H2O2 followed by treatment with 0.01 M citrate buffer (pH 6.0) for 10 min in a microwave oven, and the samples were then washed with PBS after cooling to room temperature. The sections were incubated overnight at 4 °C with primary antibody and again with biotinylated secondary antibody, followed by the addition of streptavidin-conjugated horseradish peroxidase. Immunohistochemistry staining for TH was performed using the DAB staining system according to the manufacturer's instructions. Then, the nuclei were counterstained with haematoxylin. Three sections from each group were chosen for TH detection, and the amount of TH was assessed in five randomly chosen high-power fields from each sample. The investigator was blinded to the specimen's source. The raw data were converted to an immunohistochemical score (IHS) to show the immunoreactivity of TH-positive nerves using an image analysis-based system [7].
Experimental data were analysed using SPSS version 20.00 software. Quantitative data are presented as the mean ± SD. Group comparisons were subjected to analysis of variance (ANOVA), followed by the Newman-Keuls multiple comparison test to identify significant differences between individual groups. P < 0.05 was considered statistically significant.
One dog died due to a malignant arrhythmia on the 1st day in the MI group, and one dog died on the 3rd day in the MI + RDN group. There were no deaths in the control group.
Baseline parameters
Dogs in each group were assessed for LVEDD, LVESD, FS, LVEF, LVEDP, LVSP and HR before MI (shown in Table 2) and there were no significant baseline differences between the three groups.
Table 2 Baseline data for each group
Cardiac function and haemodynamic parameters at 4 weeks post-MI
At 4 weeks post-MI, compared to the control group, dogs from the MI and MI + RDN groups showed increased LVEDD, LVESD and LVEDP, while the LVEF, FS and LVSP values were all reduced. Importantly, compared with the MI group, parameters such as LVEF, LVEDD, LVESD and LVEDP were significantly improved in the MI + RDN group, but no significant difference was observed in FS and LVSP (P = 0.092 and P = 0.931, respectively). Additionally, there were no significant differences in HR among the three groups (shown in Table 3).
Table 3 Data for cardiac function and haemodynamic parameters at 4 weeks post-MI
Cardiac oxidative stress levels
As shown in Fig. 1, the cardiac infarct border zone was obtained to assess oxidative stress levels. At 4 weeks post-MI, the activities of MDA, p47phox, and ASAFR were all increased compared to the control group, while RDN treatment significantly reduced these changes (shown in Fig. 1a-c). SOD activity in the control, MI, and MI + RDN groups was 159.77 ± 11.90 U/mg prot, 105.14 ± 7.66 U/mg prot and 140.01 ± 14.10 U/mg prot, respectively (shown in Fig. 1d).
Cardiac oxidative stress levels in each group. a MDA, (b) p47phox subunit, (c) ASAFR, (d) SOD. * P < 0.05 vs. control group;# P < 0.05 vs. MI group
Activity of the cardiac RAS
Compared with the control group, the expression of AngII, ACE2, Ang(1–7) and MasR in myocardial tissue was significantly increased in the MI and MI + RDN groups. After intervention with RDN, the levels of AngII, ACE2, Ang(1–7) and MasR were significantly decreased in the RDN-treated group compared to the MI group (shown in Fig. 2a-d).
Detection of cardiac RAS activity. a AngII, (b) ACE2, (c) Ang(1–7), (d) MasR. The levels of AngII and Ang(1–7) were measured by ELISA. The mRNA levels of ACE2 and MasR were detected through RT-PCR, and GAPDH was used as an internal control. * P < 0.05 vs. control group; # P < 0.05 vs. MI group
Activity of the cardiac SNS
Four weeks post-MI, the relative expression of TH-positive nerves in the myocardial tissue from the control, MI and MI + RDN groups was 66.82 ± 13.09, 134.16 ± 12.06, and 101.14 ± 3.91, respectively. Compared with the control group, the amount of TH-positive nerves was markedly elevated in the MI and MI + RDN groups. Importantly, a decrease in TH-positive nerves was seen in the MI + RDN group compared with the MI group (shown in Fig. 3a-b).
a TH immunohistochemical staining at the infarct border zone of nerve fibres (×400). Compared with the control group, the TH nerve fibres in the MI and MI + RDN groups were increased. However, after treatment with RDN, the quantity of TH nerve fibres was significantly decreased, and an orderly appearance of fibres was observed. b Expression of TH-positive nerves in cardiac tissues. * P < 0.05 vs. control group;# P < 0.05 vs. MI group
The expression of TH, AngII and Ang(1–7) was positively correlated with MDA (all P < 0.05) and negatively correlated with SOD (all P < 0.05). The correlation indexes are listed in Table 4.
Table 4 Correlation analysis
TH-positive nerves in renal tissue
Four weeks after MI, the relative expression of TH-positive nerves in renal tissue in the control, MI and MI + RDN groups was 93.44 ± 10.86, 102.26 ± 18.98, 75.69 ± 14.67, respectively. A decrease in TH-positive nerves was seen in the MI + RDN group compared to the MI group, while no significant difference (P = 0.071) was observed between the control and MI + RDN groups (shown in Fig. 4a-b).
a TH immunohistochemical staining of nerve fibres in renal tissue (×400). Compared with the MI group, the density of TH nerve fibres was decreased in the MI + RDN group; no difference was observed between the control and MI + RDN groups. b Expression of TH-positive nerves in renal tissues. # P < 0.05 vs. MI group
Comparison of serum creatinine at 4 weeks post-MI in each group
The serum creatinine levels in the control, MI and MI + RDN groups were 56.00 ± 19.12 μmol/L, 62.20 ± 12.79 μmol/L and 64.80 ± 20.40 μmol/L, respectively. No difference in serum creatinine among the three groups was detected (P = 0.706, shown in Fig. 5).
Serum creatinine levels at 4 weeks post-MI in each group. No differences were observed in serum creatinine among the three groups
Mounting evidence suggests that RDN is beneficial at improving cardiac function in both experimental animals and clinical patients. Hu et al. found that RDN was superior to monotherapy with a beta blocker, ACEI or ARB in decreasing plasma norepinephrine (NE) levels and improving cardiac function in rats with MI [8]. A significant improvement in diastolic function and a lowered LV mass index were also seen in RDN-treated refractory hypertension patients [9]. The present study showed that cardiac function was deteriorated after MI and that RDN inhibited the process of ventricular remodelling and improved cardiac function. Acute MI results in an increase in SNS and RAS activity in both the whole body and local myocardial tissues, which is proportional to the severity of post-MI HF [10, 11]. Additionally, reactive oxygen species (ROS), as the main effectors of oxidative stress, play an important role in the ventricular remodelling that occurs after MI [12]. Many studies have shown that RDN is effective at reducing the whole-body activity of the SNS and RAS. In our study, we explored the effect of RDN on cardiac oxidative stress and local activity of the SNS and RAS.
Previous studies have demonstrated that antioxidant therapy distinctly inhibits oxidative stress, delays ventricular remodelling and improves cardiac function after MI [13, 14]. Oxidative stress results from imbalance of the antioxidant and oxidant systems, which leads to excessive ROS production. The biological effects of nicotinamide adenine dinucleotide phosphate (NADPH) oxidase, one of the principle sources of ROS in the cardiovascular system [15], are regulated by antioxidant enzymes such as SOD and catalase. The NADPH p47phoxsubunit, composed of 390 amino acids, acts as a connector between the components of the membrane and cytoplasm and is essential for NADPH oxidase activation [16] and interstitial fibrosis [17]. MDA, the lipid peroxidate product, is used as a measure of the body's oxidative levels. SOD is a vital antioxidant enzyme and effectively clears free oxygen radicals. In our study, we found that RDN reduced the high level of oxidative stress after MI. In addition, the activity of ASAFR in dogs from the MI + RDN group was lower than in those from the MI group. Regarding this phenomenon, we propose that RDN reduces the myocardial oxidative level mainly through decreasing the generation of superoxide rather than increasing the activity of ASAFR, which clears superoxide production.
It is well known that chronic sustained sympathetic over-activity results in the aggravation and deterioration of HF. Previously published studies have shown that RDN can reduce HR, NE overflow and muscle SNS activity [18–20]; meanwhile, RDN has also demonstrated beneficial effects in various conditions with high SNS activity, such as resistant hypertension, HF, malignant arrhythmia, impaired glucose tolerance and chronic renal dysfunction [1, 21–23]. Research has further demonstrated that TH-positive nerves can be used as an indirect indicator of sympathetic activity [24]. In our research, the effectiveness of removing sympathetic nerve activity by RDN was demonstrated by the decrease in TH-positive fibres in renal tissues. Moreover, the relative expression of TH nerve fibres, which reflects the local activity of the SNS, was also down-regulated in cardiac tissue, suggesting that RDN lowered the over-activation of the SNS in myocardial tissues.
The RAS is also a crucial mediator of myocardial fibrosis, pathological hypertrophy and HF [25, 26]. The adverse effects of the RAS on cardiovascular disease are mainly due to increased AngII, which exerts its effects through the classical ACE-AngII-AT1R axis. Importantly, the ACE2-Ang(1–7)-MasR axis, known as an endogenous counter-regulator of the RAS, has been confirmed to be protective in CHF [27]. The development of cardiovascular disease has been found to involve to both axes of the RAS [28]. ACE2's major biological function is converting AngII into Ang(1–7), which is the physiological antagonist of AngII [29–31]. Ang(1–7) exerts vasodilatory, anti-proliferative, anti-inflammatory, and protective effects through activation of MasR. Previous studies have shown that ACE2 is increased in MI or HF [32–35]. As reported previously, the ACE2 gene was upregulated in HF patients and was associated with the degree of LVEDD and LVEF loss [36]. In agreement with previous investigations, our study showed that AngII and the compensatory ACE2-Ang(1–7)-MasR axis were increased in MI dogs, although these changes were reversed by ablation of renal sympathetic nerves. The exact mechanisms for the decreased expression of ACE2-Ang(1–7)-MasR after RDN are not fully understood; we speculate that RDN effectively inhibits LV dilatation and modifies cardiac function by reducing the activation of AngII to a significantly higher degree, which in turn leads to a relatively weakened compensatory mechanism. Importantly, a previous study reported that the enhanced ACE2 and Ang(1–7) levels were significantly reduced after treatment with Telmisartan in rats with HF [32], which is consistent with our results.
Cardiac SNS, RAS and oxidative stress mutually influence each other. AngII-induced phosphorylation of p47phox [16] and myocardial hypertrophy induced by ROS mediate various signalling pathways [37]. Moreover, the AngII type 1 receptor (AT1R) blocker irbesartan and Ang(1–7) blocked NADPH oxidase activation and thus restored systolic function and carotid flow in an animal study [38, 39]. Other studies have shown that ROS increase SNS activity both in the central and peripheral nervous systems [40]. In our study, we found that RDN lowered the expression of AngII, MDA and TH-positive nerve fibres in the heart, and the change in MDA was positively correlated with AngII and TH. Our preliminarily hypothesis is that RDN improves cardiac function by reducing the activity of the cardiac AngII-ROS-SNS axis, which needs to be confirmed in future research.
Safety issues related to the procedure for RDN have attracted great attention. The REACH Pilot study evaluated the safety of RDN for HF, and no significant reduction in blood pressure or other haemodynamic disturbances were observed [1]. Mahfound et al. found that RDN reduced the renal resistance index without decreasing the glomerular filtration rate (GFR), and no renal artery stenosis or dissection was recorded [41]. Hering et al. demonstrated that RDN had no negative influence on patients with renal insufficiency [23]. In the present study, the LVSP and serum creatinine level showed no significant difference after RDN compared with the non-RDN treated group, thereby demonstrating the short-term safety of the RDN procedure.
RDN exerts a protective effect against acute MI, which may be attributed to antioxidant effects and a decrease in the local activity of the SNS and RAS. In conclusion, RDN may serve as a new therapeutic treatment for MI patients by blocking these adverse mechanisms.
With regard to our study, some limitations should be considered. First, myocardial infarction was only validated by the pathological specimen and echocardiography, and we did not evaluate the infarct size, which reduces the persuasion to a certain extent. Second, the number of subjects was not large enough, which may have affected our statistical analysis. Third, due to lack of a control + RDN group, the effects of the intervention could not be excluded completely. Finally, the observation time was short. To confirm the validity of these results, studies both in humans and animals should be undertaken on a larger scale and with a longer observation time.
ACE2:
Angiotensin converting enzyme 2
ACEI:
Angiotensin-converting enzyme inhibitors
AMI:
Ang(1–7):
Angiotensin 1 through 7
AngII:
AngiotensinII
ARB:
Angiotensin receptor blockers
ASAFR:
Anti-superoxide anion free radical
AT1R:
AngII type 1 receptor
CHF:
ELISA:
Enzyme-linked immunosorbent assay
FS:
Fraction shortening
GFR:
IHS:
Immunohistochemical score
LVEDD:
Left ventricular end-diastolic dimension
LVEDP:
Left ventricular end-diastolic pressure
LVEF:
Left ventricular ejection fraction
LVESD:
Left ventricular end-systolic dimension
LVSP:
Left ventricular systolic pressure
MasR:
Mas receptor
NADPH:
Adenine dinucleotide phosphate
Norepinephrine
Q-PCR:
RDN:
Renal sympathetic denervation
Real-time reverse transcription polymerase chain reaction
Tyrosine hydroxylase
Davies JE, Manisty CH, Petraco R, Barron AJ, Unsworth B, Mayet J, et al. First-in-man safety evaluation of renal denervation for chronic systolic heart failure: primary outcome from REACH-Pilot study. Int J Cardiol. 2013;162:189–92.
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We thank all the researchers who participated in this work.
This work was supported by the research plan of the Tianjin Application Foundation and Advanced Technology (NO.14JCYBJC26100) and the Science and Technology foundation of Tianjin Health and Family Planning Committee (NO.15KG131 and NO.2014KY11).
Data sharing is not applicable to this article as no datasets were generated during the current study.
Study design and model building: CL, LS and CL. Data collection: LS and LW. Data analysis: QF and RU. Manuscript writing: QF and CL. Final approval of the manuscript: CL. All authors read and approved the final manuscript.
All experimental protocols were approved by the local animal care and use committee (the Animal Experimental Ethics Association of Tianjin First Centre Hospital). The methods were carried out in accordance with the approved guidelines.
First Center Clinic College of Tianjin Medical University, Tianjin First Central Hospital, Tianjin, China
Qiaoli Feng & Ravi Chandra Uppada
Department of Cardiology, Tianjin First Central Hospital, 24 Fukang Road, Nankai District, Tianjin, 300192, China
Chengzhi Lu, Li Wang & Chao Li
Department of Digestion, Tianjin First Central Hospital, Tianjin, China
Lijun Song
Qiaoli Feng
Chengzhi Lu
Li Wang
Chao Li
Ravi Chandra Uppada
Correspondence to Chengzhi Lu.
Feng, Q., Lu, C., Wang, L. et al. Effects of renal denervation on cardiac oxidative stress and local activity of the sympathetic nervous system and renin-angiotensin system in acute myocardial infracted dogs. BMC Cardiovasc Disord 17, 65 (2017). https://doi.org/10.1186/s12872-017-0498-1
Received: 21 June 2016


text:
Els Toraja són un grup ètnic indígena de la regió muntanyenca del sud de Sulawesi, Indonèsia. Són uns 650.000, dels quals uns 450.000 viuen en la regència de Tana Toraja ("Terra de Toraja"). La majoria són cristians, altres són musulmans o animistes i en aquest cas les seves creences es coneixen amb el nom d'aluk ("el camí").

La paraula toraja prové de l'idioma dels Bugis:to riaja, que significa "gent de les terres altes". El govern colonial neerlandès els anomenà Toraja el 1909. Els torajans són molt coneguts pels seus molt elaborats ritus funeraris amb llocs d'enterrament excavats en penya-segats de roca, cases amb teulades amb punxes conegudes com a tongkonan, i escultures de fusta acolorides.

Notes

Referències

Bibliografia

 Buijs, Kees (2006). Powers of blessing from the wilderness and from heaven. Structure and transformations in the religion of the Toraja in the Mamasa area of South Sulawesi, Leiden: KITLV.

 Waterson, Roxana (2009). Paths and Rivers: Sa'dan Toraja Society in Transformation. Leiden: KITLV.

Enllaços externs

 Tana Toraja Traditional Settlement  - UNESCO world heritage tentative list
 tanatorajakab.go.id - Official site for Government of Tana Toraja regency
 batusura.de - A personal website containing photography and recorded music from Toraja.
 Toraja Treasures.com - Toraja online information.
 JoTravelGuide.com - A comprehensive up to date travel guide to Toraja.

Grups humans d'Àsia
Cèlebes


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This was the name given by UN pilots to the northwestern portion of North Korea near the Chinese border during the Korean War.
"MiG Alley". This part of North Korea was close to the Antung Airbase, from which the MiG-15s flew, certain their base would not be bombed. Most dogfights between the MiGs and the UN forces took place in the alley.


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text:
Home/News/Aussie Steals Over 100,000 XRP – Ripple Signals a New Rally
Aussie Steals Over 100,000 XRP – Ripple Signals a New Rally
Jamie West Send an email August 11, 2020
SAN FRANCISCO, California – Australian women spends her time in jail after transferring stolen XRP worth 100,000. Ripple rises again after establishing significant support over $0.28 against the United States or the US dollar. Price trades over $0.30.
As per Information Age's report, an Australian news outlet, Kathryn Nguyen, a 25-year-old Aussie, received a sentence from Judge Chris Craigie, and it will last for two years and three months. The reason is for hacking the digital wallet of a victim. She got more than 100,000 XRP units.
Nguyen and an associate penetrated an older man's digital asset, 56 years old, and she got the funds after exchanging the two-factor authentication of the older man to her mobile phone. After that, she transferred the XRP she stole to an unidentified exchange, and it's where she exchanged these for Bitcoin. Lastly, she distributed the funds across different digital wallets.
The funds' worth is below USD 30,000. However, she exchanged these at the peak of the digital asset in the year 2018, as per the report. It was back when it's up to $300,000.
Judge Craigie stated that it was an "out of character" crime. The judge also said that Nguyen's "moral judgement was distorted" at one time.
After a 12-month analysis, the police raided the house of Nguyen in a suburb in Sydney, Epping, last year. They seized her mobile phones, computers, and money.
Matthew Craft, the Detective Superintendent, stated that it's a cyber-connected. It's a national issue, and it's not only happening in New South Wales's state.
As per the report of Age, Nguyen is the first Aussie to face charges due to cryptocurrency-theft.
As for Ripple, this digital asset found support close to the price level of $0.2800 after a substantial downside correction. The price began a steady increase over the resistance-levels of $0.2850 and $0.2920.
The upward movement was optimistic, and it had a close over the $0.2920-price level. The XRP price is exchanging over the 100 SMA or simple moving average. Also, there's a break over the 50% Fib retracement level with a downward movement. It's from a $0.3200-swing to $0.2789-swing low.
Most prominently, there's a break over the significant bearish trend line, and it has a resistance level close to $0.2990 on the XRP/USD pair. The pair is exchanging over the $0.3000-price level.
The next resistance level is close to the $0.3050-level. It's near to the 61.8% Fib retracement level with a downward movement, from $0.3200 to $0.2789. The successful break over the $0.3050-price level might open opportunities for more increases over the price levels of $0.3120 and $0.3150.
The main problem is close to the $0.3200-price level. The bulls are probable to target a more significant rally in the future to the price levels of $0.3500 to $0.3600.
The first chief support is close to the price level of $0.2920 on the downside. There would be a bearish wave-risk if Ripple didn't succeed in continuing over $0.3050.
The significant support is close to the price level of $0.2800. The price might begin a stable decline to the $0.2650 level.
associate Aussie Australia cryptocurrency digital asset digital wallet exchange hacking jail NSW old police sentence stealing theft transfer victim virtual wallet XRP
XRP Might Begin a "Moon Mission" – Poises to Hit $0.93
XRP Drops Bigtime at $0.2766 – Ripple and Flare Become Partners


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text:
Joni Mitchell relives yearly tour on album
by Kate Jewett
Pendulum (Elon College NC)
For Joni Mitchell fans who missed seeing her when she was on tour last year, Shadows and Light can help fill the void. This double album, recorded live at the Santa Barbara County Bowl in September '79, shows the versatility of the multi-talented Mitchell.
Shadows and Light differs greatly from Mitchell's other live LP, Miles of Aisles (released in 1974). Through the influence of the late Charles Mingus, Joni has become jazzier.
With an impressive band made up of Michael Brecker, Jaco Pastorius, Pat Metheny, Don Alias, and Lyle Mays, Mitchell performs songs from her past albums as well as some new ones.
The classics - "Free Man in Paris," Coyote," and "Woodstock" are present along with a bongo solo by Alias which moves into "Dreamland."
On side three of the album, the Persuasions (who played backup on the tour) join Mitchell in singing a rockin' and rollin' "Why Do Fools Fall In Love?" They also add their acappella [sic] sound to the title cut "Shadows and Light," and the crowd joins in on "God Must Be A Boogie Man."
Shadows and Light is a great album. Joni Mitchell is lively, new, nice and jazzy. And those fans who did see her on tour will love reliving the concert.
Printed from the official Joni Mitchell website. Permanent link: https://jonimitchell.com/library/view.cfm?id=3753
Copyright protected material on this website is used in accordance with 'Fair Use', for the purpose of study, review or critical analysis, and will be removed at the request of the copyright owner(s). Please read 'Notice and Procedure for Making Claims of Copyright Infringement' at JoniMitchell.com/legal.cfm


Discussion in 'Acronis True Image Product Line' started by Treogen, Oct 26, 2008.
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Could you please clarify if you are trying to recover the image on same system and hard drivers or not? Is there any file system and operating system on the destination hard drive or not? Please also make sure that you are using the latest build of the software (9615) that is available at our web site.
yes, the restore is on the same system. Actually, right after the backup without rebooting. There's no operating system on the specific disk. It's just one large (1TB) primary partition formatted with NTFS that I use to store everything. But it doesn't matter if I backup some files from my system partition on another disk and try to restore them - the button's disabled as well.
Meanwhile, I created a rescue media with the BartPE plugin and interestingly it shows the same behavior as the Linux based rescue media. The button for restoring to the original location is always disabled. I can only choose another location but then it doesn't matter if I choose the original location as the other location.
If I use the windows version of ATIH 2009 I can restore to the original location or another location. I'm using the most recent build as well.
I wonder if it makes a difference for the rescue media that I configured my SATA drives to AHCI mode in the bios.