text:
///////////////////////////////////////////////////////////////////////////////
// Copyright (c) 2002, Eric D. Friedman All Rights Reserved.
// Copyright (c) 2009, Robert D. Eden All Rights Reserved.
// Copyright (c) 2009, Jeff Randall All Rights Reserved.
//
// This library is free software; you can redistribute it and/or
// modify it under the terms of the GNU Lesser General Public
// License as published by the Free Software Foundation; either
// version 2.1 of the License, or (at your option) any later version.
//
// This library is distributed in the hope that it will be useful,
// but WITHOUT ANY WARRANTY; without even the implied warranty of
// MERCHANTABILITY or FITNESS FOR A PARTICULAR PURPOSE.  See the
// GNU General Public License for more details.
//
// You should have received a copy of the GNU Lesser General Public
// License along with this program; if not, write to the Free Software
// Foundation, Inc., 59 Temple Place - Suite 330, Boston, MA  02111-1307, USA.
///////////////////////////////////////////////////////////////////////////////

package gnu.trove.decorator;

import gnu.trove.map.TFloatLongMap;
import gnu.trove.iterator.TFloatLongIterator;

import java.io.*;
import java.util.*;

//////////////////////////////////////////////////
// THIS IS A GENERATED CLASS. DO NOT HAND EDIT! //
//////////////////////////////////////////////////

/**
 * Wrapper class to make a TFloatLongMap conform to the <tt>java.util.Map</tt> API.
 * This class simply decorates an underlying TFloatLongMap and translates the Object-based
 * APIs into their Trove primitive analogs.
 *

 * Note that wrapping and unwrapping primitive values is extremely inefficient.  If
 * possible, users of this class should override the appropriate methods in this class
 * and use a table of canonical values.
 *

 * Created: Mon Sep 23 22:07:40 PDT 2002
 *
 * @author Eric D. Friedman
 * @author Robert D. Eden
 * @author Jeff Randall
 */
public class TFloatLongMapDecorator extends AbstractMap<Float, Long>
	implements Map<Float, Long>, Externalizable, Cloneable {

	static final long serialVersionUID = 1L;

    /** the wrapped primitive map */
    protected TFloatLongMap _map;

    /**
     * FOR EXTERNALIZATION ONLY!!
     */
    public TFloatLongMapDecorator() {}

    /**
     * Creates a wrapper that decorates the specified primitive map.
     *
     * @param map the <tt>TFloatLongMap</tt> to wrap.
     */
    public TFloatLongMapDecorator( TFloatLongMap map ) {
        super();
        this._map = map;
    }

    /**
     * Returns a reference to the map wrapped by this decorator.
     *
     * @return the wrapped <tt>TFloatLongMap</tt> instance.
     */
    public TFloatLongMap getMap() {
        return _map;
    }

    /**
     * Inserts a key/value pair into the map.
     *
     * @param key   an Object value
     * @param value an Object value
     * @return the previous value associated with <tt>key</tt>,
     *         or Long(0) if none was found.
     */
    public Long put( Float key, Long value ) {
        float k;
        long v;
        if ( key == null ) {
            k = _map.getNoEntryKey();
        } else {
            k = unwrapKey( key );
        }
        if ( value == null ) {
            v = _map.getNoEntryValue();
        } else {
            v = unwrapValue( value );
        }
        long retval = _map.put( k, v );
        if ( retval == _map.getNoEntryValue() ) {
            return null;
        }
        return wrapValue( retval );
    }

    /**
     * Retrieves the value for <tt>key</tt>
     *
     * @param key an Object value
     * @return the value of <tt>key</tt> or null if no such mapping exists.
     */
    public Long get( Object key ) {
        float k;
        if ( key != null ) {
            if ( key instanceof Float ) {
                k = unwrapKey( key );
            } else {
                return null;
            }
        } else {
            k = _map.getNoEntryKey();
        }
        long v = _map.get( k );
        // There may be a false positive since primitive maps
        // cannot return null, so we have to do an extra
        // check here.
        if ( v == _map.getNoEntryValue() ) {
            return null;
        } else {
            return wrapValue( v );
        }
    }

    /**
     * Empties the map.
     */
    public void clear() {
        this._map.clear();
    }

    /**
     * Deletes a key/value pair from the map.
     *
     * @param key an Object value
     * @return the removed value, or null if it was not found in the map
     */
    public Long remove( Object key ) {
        float k;
        if ( key != null ) {
            if ( key instanceof Float ) {
                k = unwrapKey( key );
            } else {
                return null;
            }
        } else {
            k = _map.getNoEntryKey();
        }
        long v = _map.remove( k );
        // There may be a false positive since primitive maps
        // cannot return null, so we have to do an extra
        // check here.
        if ( v == _map.getNoEntryValue() ) {
            return null;
        } else {
            return wrapValue( v );
        }
    }

    /**
     * Returns a Set view on the entries of the map.
     *
     * @return a Set value
     */
    public Set<Map.Entry<Float,Long>> entrySet() {
        return new AbstractSet<Map.Entry<Float,Long>>() {
            public int size() {
                return _map.size();
            }

            public boolean isEmpty() {
                return TFloatLongMapDecorator.this.isEmpty();
            }

            public boolean contains( Object o ) {
                if (o instanceof Map.Entry) {
                    Object k = ( ( Map.Entry ) o ).getKey();
                    Object v = ( ( Map.Entry ) o ).getValue();
                    return TFloatLongMapDecorator.this.containsKey(k)
                            && TFloatLongMapDecorator.this.get(k).equals(v);
                } else {
                    return false;
                }
            }

            public Iterator<Map.Entry<Float,Long>> iterator() {
                return new Iterator<Map.Entry<Float,Long>>() {
                    private final TFloatLongIterator it = _map.iterator();

                    public Map.Entry<Float,Long> next() {
                        it.advance();
                        final Float key = wrapKey( it.key() );
                        final Long v = wrapValue( it.value() );
                        return new Map.Entry<Float,Long>() {
                            private Long val = v;

                            public boolean equals( Object o ) {
                                return o instanceof Map.Entry
                                        && ( ( Map.Entry ) o ).getKey().equals(key)
                                        && ( ( Map.Entry ) o ).getValue().equals(val);
                            }

                            public Float getKey() {
                                return key;
                            }

                            public Long getValue() {
                                return val;
                            }

                            public int hashCode() {
                                return key.hashCode() + val.hashCode();
                            }

                            public Long setValue( Long value ) {
                                val = value;
                                return put( key, value );
                            }
                        };
                    }

                    public boolean hasNext() {
                        return it.hasNext();
                    }

                    public void remove() {
                        it.remove();
                    }
                };
            }

            public boolean add( Map.Entry<Float,Long> o ) {
                throw new UnsupportedOperationException();
            }

            public boolean remove( Object o ) {
                boolean modified = false;
                if ( contains( o ) ) {
                    //noinspection unchecked
                    Float key = ( ( Map.Entry<Float,Long> ) o ).getKey();
                    _map.remove( unwrapKey( key ) );
                    modified = true;
                }
                return modified;
            }

            public boolean addAll( Collection<? extends Map.Entry<Float, Long>> c ) {
                throw new UnsupportedOperationException();
            }

            public void clear() {
                TFloatLongMapDecorator.this.clear();
            }
        };
    }

    /**
     * Checks for the presence of <tt>val</tt> in the values of the map.
     *
     * @param val an Object value
     * @return a boolean value
     */
    public boolean containsValue( Object val ) {
        return val instanceof Long && _map.containsValue( unwrapValue( val ) );
    }

    /**
     * Checks for the present of <tt>key</tt> in the keys of the map.
     *
     * @param key an Object value
     * @return a boolean value
     */
    public boolean containsKey( Object key ) {
        if ( key == null ) return _map.containsKey( _map.getNoEntryKey() );
        return key instanceof Float && _map.containsKey( unwrapKey( key ) );
    }

    /**
     * Returns the number of entries in the map.
     *
     * @return the map's size.
     */
    public int size() {
        return this._map.size();
    }

    /**
     * Indicates whether map has any entries.
     *
     * @return true if the map is empty
     */
    public boolean isEmpty() {
        return size() == 0;
    }

    /**
     * Copies the key/value mappings in <tt>map</tt> into this map.
     * Note that this will be a deep copy, as storage is by
     * primitive value.
     *
     * @param map a Map value
     */
    public void putAll( Map<? extends Float, ? extends Long> map ) {
        Iterator<? extends Entry<? extends Float,? extends Long>> it =
            map.entrySet().iterator();
        for ( int i = map.size(); i-- > 0; ) {
            Entry<? extends Float,? extends Long> e = it.next();
            this.put( e.getKey(), e.getValue() );
        }
    }

    /**
     * Wraps a key
     *
     * @param k key in the underlying map
     * @return an Object representation of the key
     */
    protected Float wrapKey( float k ) {
        return Float.valueOf( k );
    }

    /**
     * Unwraps a key
     *
     * @param key wrapped key
     * @return an unwrapped representation of the key
     */
    protected float unwrapKey( Object key ) {
        return ( ( Float ) key ).floatValue();
    }

    /**
     * Wraps a value
     *
     * @param k value in the underlying map
     * @return an Object representation of the value
     */
    protected Long wrapValue( long k ) {
        return Long.valueOf( k );
    }

    /**
     * Unwraps a value
     *
     * @param value wrapped value
     * @return an unwrapped representation of the value
     */
    protected long unwrapValue( Object value ) {
        return ( ( Long ) value ).longValue();
    }

    // Implements Externalizable
    public void readExternal( ObjectInput in )
        throws IOException, ClassNotFoundException {

        // VERSION
        in.readByte();

        // MAP
        _map = ( TFloatLongMap ) in.readObject();
    }

    // Implements Externalizable
    public void writeExternal( ObjectOutput out ) throws IOException {
        // VERSION
        out.writeByte(0);

        // MAP
        out.writeObject( _map );
    }

} // TFloatLongHashMapDecorator


A new report on Sudan, published earlier this week by the Enough Project, says the US must consider Sudan's persecution of Christians and other minority groups before it lifts the remaining sanctions against the country.
The report, 'Radical Intolerance: Sudan's Religious Oppression and Embrace of Extremist Groups', says Sudan is guilty of "discreet and systematic acts of persecution".
The government uses a 'divide and rule' policy to exploit differences within and between communities, according to the report, which says Sudan, among other things, "supports a group that rivals the official Church of Christ representative body", resulting in attacks on leaders and destruction of property.
"The attacks on Christian communities are particularly brazen and noteworthy for the fact that they come as US policymakers, who hold significant leverage, scrutinise the regime's behaviour in the wake of the lifting of US sanctions and amid consideration of further normalisation of bilateral relations," says the report, written by Dr. Suliman Baldo, an expert on conflict resolution.


So, the g400 line is being replaced in January. The g400 max will still remain current.
I keep saying .... I don't know what Ping can do to improve their G400 driver, it's the best product I've ever hit over the past 25 years. As for their other woods, hybrids & irons, I imagine they'll come up with some trick to get WRX's to try & buy next year.
What do you mean already? The G400 came out summer 17. Ping is on an 18 month product cycle. That's common knowledge.
That's a surprise, if true.
Good...lemme get a G400 MAX under $200 lightly used and I'm a buyer.
Hard to believe they could improve on the G400.
Release date is still up in the air from what I thought but January wouldn't surprise me, seems like they're going the PXG route and not planning on sticking with release cycles and just bringing out new tech as it comes along.
The G500 will be 100 units better. With a reduced crown weight, lower and more rearward COG, 10-way adjustable hosel, counterbalanced shaft, 12 grip options and a hidden weight in the head made of unobtanium, this driver will be faster, straighter and longer than any driver ever produced.
sdandrea .... as well, a lot less spin for everyone.
Save your money. G400 is awesome.
I was wondering if they were coming out with something new because both the adapter and weights from Golfworks are on sale now.
Please please let the new driver have a adapter system like Callaway and Titleist but only if it maintains a small diameter and weight. I think Ping engineers can make that happen.
Should just delay the release and stick with G400. Seems crazy to replace such a hot product unnecessarily.
Oh no....I really hope that's wrong and there is a LST model coming in the line, to at least hopefully drop the price of the G400 LST.
Sticking with my G400 LST, but would like to see hybrids with adjustable lofts.
Phew! I was about to b**** and moan about now having to wait till January to buy a new driver but ideally I need the lower spinning option.
Not sure how they improve the G400 line, should be interesting.
Add a high loft neutral weighted option for us low spin low launch slower swingers. Would absolutely Game a 13.5 G400Max without draw weighting.
10* Ping G400 LST Project X Hzrdus Black 75 6.0 44.5"
18* Titleist 915F Diamana BF 80 X 41.25"
21* Titleist 915H Diamana Blueboard 90 X 40"
It'll take a lot to get my G400 out of the bag. Going from an Epic SZ to M3 to this...There isn't anything better out there right now and I've tried most of them all (minus Mizuno).
Intrigued to see what may still come.


text:
UNC Sigmas host stepping workshop - Progressive Greek
UNC Sigmas host stepping workshop
11 years ago	kevin1914 College Life 0
While it is normally taboo to include outsiders in a step performance, Phi Beta Sigma Fraternity, Inc., will throw convention to the wind tonight when they host a step workshop to teach students how to step and unite the community.
Donovan Livingston, a senior history major and vice president of the campus chapter of Phi Beta Sigma, organized today's event.
He said the workshop, to be held at the Rams Head Recreation Center, is an attempt to create an "atmosphere where people can relax together" after midterms.
Stepping is a type of performance art that mingles traditional African and pop culture dance with drama, chanting and singing. It is popular in historically black fraternities and sororities.
"Stepping is very rich," said Janel Monroe, a junior communication studies major and social chairwoman of UNC's chapter of Delta Sigma Theta Sorority, Inc. "It's important to black culture."
Step is often used as a promotional tool for fraternity and community events, said Lorenzo Hopper, a junior chemistry major and step master at Phi Beta Sigma.
"It's a passion that we love dearly and take seriously," Hopper said.
The workshop also is a way to bring together Greek organizations.
Livingston said he immediately recognized gaps between different fraternities and sororities when he joined Phi Beta Sigma.
He said he is interested in other organizations, their philanthropy and how they conduct business. But he said barriers in the Greek community have prevented some of this sharing.
Cherise Washington, a junior business major and step master of the Delta Sigma Theta chapter, said she likes the idea of bringing different Greek organizations together.
"Ultimately we all fight for the same causes," Washington said.
Hopper said he is looking forward to educating people about the art of stepping.
Livingston described Hopper's title of step master as "a coveted position."
Hopper said he thrives on stepping in front of an audience.
"People love to watch it," Hopper said.
Washington said she was appointed step master due to her dance background.
"Stepping allows you to exercise your creativity in a new way," she said.
Phi Beta Sigma hosted a similar workshop last semester, which drew more than 60 people. Today's workshop will begin with a demonstration, and then attendees will be divided into small groups to learn short step segments.
Livingston said he expects more than 90 people to attend.
It shouldn't be hard for newcomers to pick it up. Stepping is fun, Washington said, and he compared it to dancing.
"Everyone loves to dance," Washington said. "Everybody can be a stepper."
Hopper said he is most looking forward to "having a lot of diversity there" and "showing our culture."
delta sigma theta phi beta sigma stepping workshop university of north carolina
Eight Virginia State Sigmas charged in hazing incident
Alphas win their 4th consecutive Little 5 Step Down
UNC Alphas hang on after intake moratorium
Ryan T. Brown named Assistant District Director-elect for the Georgia District of Alpha Phi Alpha
Univ. of Memphis lineman, Sigma Frater Dominik Riley named a finalist for Wuerffel Trophy
Penn State Kappas recognize community leadership

redpajama_set_name: RedPajamaCommonCrawl


Many people miss out on one of the best parts of the Housatonic River; the smallmouths! Pound for pound these may be the best freshwater species to catch and there are some truly monstrous bronzebacks here in the Housy. Improve your fly fishing and learn some new patterns to tie to catch these often overlooked fish. Jim Plante will be back at the shop for a smallmouth bass clinic on Saturday, July 15. You will be tying some flies and learning how to fish these flies. Cost is $25 per person and participants are asked to bring their fly tying vises and tools. You will be tying flies!


text:
microrna inhibitor
Vector-Based and Synthesized MicroRNA Inhibitors
191, P = 0·03) indicating that type I IFNs increase the amount of
Posted on January 31, 2019 by micr5634
191, P = 0·03) indicating that type I IFNs increase the amount of IL-10 produced per cell (Table 1). Thus, a decrease in the amount of IL-10 per cell and possibly in the number of IL-10-producing CD25+CD4+ T cells, as buy Peptide 17 measured by flow cytometry, correlates with the decrease in the amount of IL-10 seen by ELISA. As IgG is very important in the induction of IL-10, which helps suppress a healing Th1 response, we looked at the IgG responses in WT and KO mice infected
with L. mexicana. Leishmania-specific serum IgG1 and IgG2a/c responses were determined using L. mexicana FTAg as a capture reagent. At 12 weeks of infection, the IFN-α/βR KO had significantly more IgG1 and IgG2a/c as compared with WT mice (Figure 4a). However, by 23 weeks of infection, this difference was no longer evident, this website with both WT and KO mice having indistinguishable titres (Figure 4b). As the ELISA assay for IgG is nonlinear, we calculated the amount of IgG1 and IgG2a/c produced by WT mice relative to IFN-α/βR KO mice as described in the Materials and methods section, finding that KO mice produced 10·4-fold more IgG1 and 6·9-fold more IgG2a/c (Figure 4c). As IFN-α/β has been reported to decrease strongly the IL-12 production in some systems (18,19), we explored whether IL-12 is increased in the absence of IFN-α/βR signalling.
We measured IL-12 in the serum of infected IFN-α/βR KO and WT mice and found that IL-12 levels were not higher in KO mice at 12 or 23 weeks
post-infection (Figure 5). Although measuring IL-12 in the serum is not routine in cutaneous leishmaniasis, it has been shown that significant differences in serum IL-12 levels are measurable in L. major-infected WT and Fas-deficient mice (20). Although IFN-γ has long been known to be crucial to the control of Leishmania infection, as it is with many intracellular pathogens, the role of type I IFNs is less well understood. Type I IFNs are important in viral infections as well C-X-C chemokine receptor type 7 (CXCR-7) as infections caused by Gram-negative bacteria and parasites such as Plasmodium, and even L. major. We undertook studies to examine the role of type I IFNs in L. mexicana infection using mice that lack the common type I IFN receptor (IFN-α/βR KO mice). Our previous studies demonstrated that partial control of L. mexicana requires the transcription factor STAT4, as well as IFN-γ and iNOS (1). Without any one of these factors, mice develop progressive disease with continuously growing lesions and much higher parasite burdens, rather than controlling disease around 8–10 weeks of infection, as seen in WT B6 mice. However, we found a lack of any discernable phenotype in mice lacking IL-12p40 (a component of the heterodimeric cytokines IL-12 and IL-23).
A modified lambda-shaped LVA was performed at the left groin In
A modified lambda-shaped LVA was performed at the left groin. In modified lambda-shaped LVA, two lymphatic vessels were transected, and both ends of the proximal and distal sides were converged respectively for an end-to-side and end-to-end anastomoses to one vein. Using modified lambda-shaped LVA, four lymph flows of two lymphatic vessels could be bypassed into a vein. Six months after the LVA surgery,
her left LEL index decreased from 261 to 247, indicating GSK-3 phosphorylation edematous volume reduction. Modified lambda-shaped LVA effectively bypasses all lymph flows from two lymphatic vessels, when only one large vein can be found in the surgical field. © 2013 Wiley Periodicals, Inc. Microsurgery 34:308–310, 2014. "
"Recalcitrant nonunions typically require vascularized bone for reconstruction. In this report, we present a case of an index finger middle phalanx nonunion that was successfully treated with a free medial femoral condyle corticocancellous flap.
Nearly 2 years after the free tissue transfer, the patient underwent debulking of the bone flap. This gave us the unique opportunity to examine the histology of the vascularized bone. © 2013 Wiley Periodicals, Inc. Microsurgery 33:567–571, 2013. "
"Big craniofacial resections for highly invasive malignant neoplasm, including skull base and maxillary bones, always represent a difficult chance for the reconstructive surgeon. In these cases it is not easy to restore anatomy and function simultaneously even adopting complex microsurgical techniques. In maxillofacial and oral surgery, simple bone homotransplantation for small bone segments
reconstruction selleck chemical has been developing as popular technique and tissue banks offer not only bone segments but also many different tissues including complex body parts. In this paper we present, a case report next of a homotransplantation of a complete temporomandibular joint (TMJ) together with a portion of the medial skull base and mandibular ramus folded with an ante-brachial fascio-periosteal free flap as secondary reconstruction after nearly 5 years from the removal of a sarcoma of the TMJ involving the skull base and a follow up of more than 30 months. © 2009 Wiley-Liss, Inc. Microsurgery 2010. "
"Complex midfoot defects represent a reconstructive challenge since midfoot plays a key role in standing and gait. We report the case of a 27-year-old patient with a complex midfoot defect due to a high-energy gun shot injury. The defect included the tarsometatarsal complex, all three arches of the foot, and the overlying dorsal skin of the foot. Reconstruction was achieved in a single stage with a free fibular osteocutaneous flap. The fibula was osteotomized into three segments, which were used to reconstruct the bone defects, while the skin paddle of the flap was used for stable soft tissue coverage of the reconstructed bony skeleton. Early and late postoperative periods were uneventful.
11 The human DRPLA gene spans approximately 20 kbp and consists o
11 The human DRPLA gene spans approximately 20 kbp and consists of 10 exons, with the CAG repeats located in exon 5.12 The number of CAG repeats in normal chromosomes and DRPLA patients range from 6 to 35 and from 54 to 79, respectively.13 It is characteristic that there is anticipation in DRPLA.9,10,14 Paternal transmission results in more
prominent anticipation (26–29 years/generation) than does maternal transmission (14–15 years/generation). There is an inverse correlation between the size of expanded CAG repeats and age at onset, and also a correlation between clinical features and the repeat RAD001 in vitro size.13 DRPLA patients with longer CAG repeats show a more early onset and severer phenotypes. The physiological functions of DRPLA protein remain to p53 inhibitor be elucidated. It is generally accepted that mutant
DRPLA proteins with expanded polyglutamine stretches are toxic to neuronal cells ("gain of toxic functions"). The discovery of neuronal intranuclear inclusions (NIIs) in transgenic mice for Huntington's disease15 triggered new development of neuropathology in polyglutamine diseases, including DRPLA. NIIs are eosinophilic round structures, and easily detectable by ubiquitin immunohistochemistry (Fig. 3c). In DRPLA, they are also immunoreactive for expanded polyglutamine stretches (Fig. 3d) as well as for atrophin-1, the DRPLA gene product.16,17 Ultrastructurally, NIIs are non-membrane bound, heterogeneous in composition, and contain a mixture of granular and filamentous structures,
approximately 10–20 nm in diameter. NIIs were initially thought to be toxic structures responsible for neuronal cell death in affected brain regions; however, subsequent 2-hydroxyphytanoyl-CoA lyase investigations raised the possibility that NII formation itself might be a cellular reaction designed to reduce the acute toxic effect of the mutant proteins.18–20 In DRPLA, NIIs were detectable in multiple brain regions far beyond the dentatorubral and pallidoluysian systems, suggesting that neurons are affected much more widely than was recognized previously, although the incidences of NIIs were very low even in the affected regions.21 In 2001, it became apparent that diffuse intranuclear accumulation of the mutant DRPLA protein affects many neurons in wide area of the CNS, including the cerebral cortex (Fig. 3e–g), and that the prevalence of this pathology changes dynamically in relation to CAG repeat size. The results suggest that the novel lesion distribution revealed by the diffuse nuclear labeling may be responsible for a variety of clinical features, such as dementia and epilepsy in DRPLA.22 In addition to NIIs, skein-like inclusions were also detectable in DRPLA brains, although their appearances were restricted in the cerebellar dentate nucleus (Fig. 3h).23 To elucidate the molecular mechanisms of neuronal degeneration in DRPLA, transgenic mice harboring a single copy of a full-length human mutant DRPLA gene with 76 or 129 CAG repeats have been generated.
It includes an emphasis on the importance of providing informed c
It includes an emphasis on the importance of providing informed consent, including expected survival times, for patients being offered dialysis as well as for those not receiving dialysis. The emphasis is on considering buy Ensartinib more than days survived on dialysis such as the likely QOL, the days survived outside of hospital, and the spiritual and cultural issues of the patient and their family that
will be critical to such discussions. The section on the law hopefully provides reassurance to nephrologists that well-based decision-making done as usual in the best interests of the patient is all that the law asks; the likelihood of being sued, an often stated reason for not suggesting a non-dialysis pathway, is very small indeed. We hope that readers of this document will (i) consider all this material in a new light; and (ii) recognize that it is not evidence free. The tools used in decision-making and management are imperfect both for selecting patients best suited to dialysis and for selecting
those best suited to a non-dialysis pathway; PXD101 in vivo research strategies to improve these are outlined in this document. There is a strong emphasis in this document on the incorporation of key ethical principles into the process of decision-making regarding dialysis or non-dialysis management pathways, clear guidelines as to how to manage specific symptoms that accompany ESKD and guidelines for end of life care. It is imperative that patients and families are enrolled in such a programme long before the end stage of their CKD pathway so that they are aware of future clinical trajectories and feel supported throughout. A key message we hope to impart is that a well-structured Renal Supportive and Palliative Care programme without dialysis is a very positive part
of the management of ESKD for some patients and one that should not be overlooked. This document has been endorsed by Kidney Health Australia and the Australian and New Zealand Society second of Nephrology. Nephrologists seek to provide dialysis to those who will benefit most. There are some who are unlikely to benefit or even be harmed by dialysis and it is important that we try to recognize such patients; these can be very difficult decisions. In older patients with co-morbidities the decision to initiate dialysis can be very difficult; helpful things to consider include: the number of cardiac or other co-morbidities, nutritional status, functional status, whether or not the patient is in a nursing home, and how the nephrologist responds to the question: 'would you be surprised if your patient died within 12 months?' Taken together, these issues help identify patients at risk of a poor outcome on dialysis.
The use of antiviral prophylaxis versus no prophylaxis reduced CM
The use of antiviral prophylaxis versus no prophylaxis reduced CMV disease (see the forest plot in 1), CMV infection and all cause mortality (see forest plot in PLX-4720 datasheet 2), primarily by reducing
CMV related mortality, in transplant recipients of all ages who have at risk CMV status (CMV +ve or CMV –ve recipients of CMV +ve organs) pre-transplantation. There was also a reduction in herpes simplex and zoster, bacterial and protozoal infections. No significant benefit was found for fungal infections, acute rejection or graft loss. There was an increase in the risk of neurological dysfunction (hallucinations, headaches etc) with ganciclovir and valaciclovir compared with placebo or no treatment. The decrease in CMV disease was consistent regardless of organ transplanted, treatment with an anti-lymphocyte agent Roscovitine and CMV serostatus. Comparing antiviral medications, ganciclovir was more effective than aciclovir for CMV disease prevention and also resulted in less leucopaenia. Valganciclovir did not differ significantly from ganciclovir. Considering duration of treatment, extended duration prophylaxis
in kidney or lung transplant recipients significantly reduced the risk of CMV disease compared with the standard 3 months of therapy with the only trade off being more leucopaenia, with
no other severe treatment associated side effects noted. Thirty seven randomised control trials (4342 patients) were included in the data synthesis. Nineteen trials compared aciclovir (6 trials), ganciclovir (11 trials) or valaciclovir (2 trials) with placebo or no treatment for recipients of different solid organ transplants 3-mercaptopyruvate sulfurtransferase (17 trials kidney, 12 trials liver, 3 trials heart, 2 trials lung, 2 trials all, 1 trial combined heart/lung). Fifteen of these trials excluded negative CMV status in both donor and recipient. A further 13 trials compared different antiviral agents and 5 trials compared different regimens of the same antiviral agent. Domains of methodological quality in the design and reporting of included trials were generally not well reported. Sequence generation and allocation concealment were at low risk of bias in 12/37 trials (32%). Ten out of 37 (27%) trials and 9/37 (24%) trials had appropriate blinding of participants/investigators and outcome assessors respectively. Attrition bias was low in the majority of trials (92%). Thirteen of the 37 (35%) trials were sponsored by the pharmaceutical industry.
Tetraspanins can potentially contribute to both adhesion-dependen
Tetraspanins can potentially contribute to both adhesion-dependent and adhesion-independent DC migration. Tetraspanins are best characterized by their ability to molecularly interact with integrins — adhesion molecules important in regulating cell migration in many diverse cell types [2]. Tetraspanins regulate integrin function, as frequently observed in the impaired adhesion and migration of tetraspanin-deficient cells of various lineages [27, 29-31]. Similarly, we demonstrate that adhesion to fibronectin is impaired in CD37−/− DCs under low shear flow (Fig. 6A) implicating a role for CD37 in regulating
outside-in signaling of α4β1 and/or α5β1 integrins in DCs. Tetraspanins are also known to interact with the cytoskeleton selleck chemicals llc via molecular interactions with ezrin/radixin/moesin proteins [37], and cross-linking tetraspanins at the cell surface can drive cytoskeletal rearrangement [38]. In find more this study we observed impaired CD37−/− DC function in two processes known to require cytoskeletal rearrangement: integrin outside-in signaling, investigated by measuring adhesion under flow (Fig. 6A), as well as
cell spreading to form membrane protrusions (Fig. 6C–G). An effect of CD37 ablation on cytoskeletal rearrangement is also consistent with a recent report that the absence of another tetraspanin, CD81, results in inhibited integrin-dependent in vitro DC chemotaxis [28] and the formation of membrane protrusions, driven by
a dysregulation of Rac-1 activation. While the new in vivo immunological effects of impaired migration of CD81−/− DCs were not studied [28], in the present paper it is clear that CD37 ablation profoundly affects in vivo DC migration which is the likely cellular mechanism that underlies the poor cellular immunity induced in CD37−/− mice. The next challenge is to unravel the molecular interactions of CD37 in DCs. C57BL/6 (WT), C57BL/6.CD37−/− (CD37−/−) [10], CD11cYFP, CD37−/−.CD11cYFP, and OT-I Ly5.1 mice were bred in house, or obtained from the Walter and Eliza Hall Institute (Melbourne, Australia). Mice were housed under SPF conditions within the Burnet Institute animal facility (Austin Campus), the AMREP Animal Services, or the Nijmegen Medical Centre and used between 8 and 12 weeks of age. In vivo multiphoton imaging was performed on 8–10-week-old female CD37−/−.CD11cYFP mice with CD11cYFP mice used as controls. The corresponding campus animal ethics committees at Austin Hospital, AMREP Animal Services, Monash Medical Centre, or Nijmegen Medical Centre approved all animal experiments. Mice were challenged subcutaneously with 1–5 × 106 cells from either RMA (C57BL/6 — T-cell lymphoma) or RMA-Muc1 as described previously [39].
Cells in co-cultures were labelled with Annexin (FITC), Propidium
Cells in co-cultures were labelled with Annexin (FITC), Propidium iodide and CD14 (PE, clone 61D3) (eBioscience) for
flow cytometric analysis of monocytic cell death. All experimental data are represented as median (range). The Mann–Whitney variance analysis (t-test) was used to compare the groups; and the Kruskal–Wallis test compared the stimulated and unstimulated (NS) cells in each group. The adopted statistical significance level was P < 0·05. According to Ridley–Jopling criteria, all HIV/leprosy co-infected patients evaluated in this study were classified with the borderline tuberculoid form of leprosy. Seven of these patients presented RR episodes at leprosy diagnosis whereas three patients presented RR during leprosy treatment. The leprosy diagnosis of all HIV/leprosy co-infected patients was determined after diagnosis of HIV. All HIV/leprosy PLX3397 co-infected patients were under HAART for at least 1 year and presented an undetectable viral load as well as an increase in CD4+ T-cell numbers at the moment of RR leprosy diagnosis (Table 1). For this reason, the RR episode in these DNA Damage inhibitor patients was considered a HAART-related leprosy episode.[23] Ten RR patients without HIV were included in this study. Six of these individuals were
classified as borderline tuberculoid and four presented with the borderline lepromatous form of the disease. The clinical and demographic characteristics of all patients are summarized in Table 1. To determine basal IFN-γ production as well as the T-cell phenotype in RR and RR/HIV co-infected patients, fresh PBMCs from five different patients for each group,
including the HC group, were assayed CYTH4 in an ex vivo ELISPOT and flow cytometric assay. As observed in Fig. 1(a), the number of IFN-γ spot-forming cells was higher in RR/HIV than in the RR and HC groups [HC 130 (30–260) versus RR/HIV 1010 (290–1560); P < 0·01; RR 180 (50–340) versus RR/HIV 1010 (290–1560); P < 0·05]. In addition, RR/HIV presented increased percentages of CD4+ CD69+ cells when compared with both HC and RR [Fig. 1b,c; HC 2·72 (1·57–5·42) versus RR/HIV 89·42 (74·58–97·90); P < 0·001; RR 5·42 (0·57–12·17) versus RR/HIV 89·42 (74·58–97·90); P < 0·001]. The same profile was observed after evaluating the CD38 pattern in the CD4 population [Fig. 1b,c; HC 4·70 (2·54–10·78) versus RR/HIV 43·56 (4·77–55·10); P < 0·01; RR 7·54 (3·20–10·38) versus RR/HIV 43·56 (4·77–55·10); P < 0·01] and on CD8 population [Fig. 1b,c; HC 4·47 (1·0–22·62) versus RR/HIV 52·44 (33·80–82·90); P < 0·001; RR 4·52 (3·0–20·60) versus RR/HIV 52·44 (33·80–82·90); P < 0·001]. In relation to the CD8+ CD69+ cells, no significant difference was observed between RR/HIV and the RR and HC groups (Fig. 1b,c). To determine whether the T-cell response in RR/HIV patients was ML specific, PBMCs from five different patients of each group were assayed in an in vitro ELISPOT assay.
In addition, some evidence indicates that co-activation of c-Kit
In addition, some evidence indicates that co-activation of c-Kit 15, CD28 16, CD226 7 and CCR1 17 with FcεRI results in the modulation of the MC response. Several studies provide supporting information about the
expression of co-stimulatory cell surface molecules, including members of the B7 family (ICOSL, PD-L1 and PD-L2) 8, 10, 18 and the TNF/TNFR families (OX40L, CD153, Fas, 4-1BB and GITR) 10, 19, 20. More recently, see more considerable progress in understanding the importance of physical contact and cell surface receptors was yielded by the discovery that MCs and Tregs interact via OX40L and OX40. This axis defines a previously unrecognized mechanism controlling both MC degranulation and Treg suppression 4, 5. The finding that the interaction of OX40-expressing Tregs with OX40L-expressing MCs decreased the extent of MC degranulation in vitro and reduced the amplitude of the immediate hypersensitivity response in vivo highlights
the existence of functionally important Erlotinib datasheet MC–Treg cross-talk, raising the question of whether these cognate interactions might occur in the course of the immune response. Interestingly, the cross-talk between MCs and Tregs results in inhibition of early events induced by FcεRI triggering, such as release of histamine and proteolytic enzymes, without affecting cytokine and chemokine secretion 4. To investigate how conjugates could be established between murine and human MCs and CD4+CD25+ Tregs and how they could explain
selective T-cell-mediated modulation of MC functions, we examined the kinetics, morphological features and functional profile of cell–cell interaction and cell conjugate formation. We have reported that Tregs, but not activated T cells, can inhibit the MC allergic response without affecting cytokine release, through a cell–cell contact-dependent interaction 4. To analyze the dynamics of this process, we performed real-time imaging of MC–Treg cognate interactions. By time-lapse bright-field video microscopy, we analyzed the formation of conjugates between IgE-presensitized murine bone marrow MCs (BMMCs) and CD4+CD25+ Tregs. The time series started after Ag addition and cell behavior was observed every minute for Farnesyltransferase a total of 30 min. Each cell type was distinguished by its unique morphological characteristics. BMMCs were large (about 15–20 μm) and round, whereas Tregs were smaller (8–10 μm) with tiny cytoplasm. Under resting conditions both BMMCs and T cells were typically rounded, while during cell–cell contact both cell types became elongated and flattened (Fig. 1A). Early BMMC tethering failed to result in firm adhesion; the BMMC moved across the T cell, forming a mobile junction with a dynamic contact plane (not shown). Individual interactions showed sequential phases of adhesion, slow later movement and dynamic crawling in different proportions and duration.
Mast cells are activated by antigen crosslinking of IgE-bound hig
Mast cells are activated by antigen crosslinking of IgE-bound high-affinity receptor for IgE (FcεRI) receptors, and aggregation of these receptors results in rapid phosphorylation of tyrosine residues in the ITAMs of β and γ chains by lyn kinase, which leads to recruitment and activation of spleen tyrosine kinase (syk) and fyn. Deforolimus cost Both fyn and syk phosphorylate downstream targets, leading to calcium mobilization,
degranulation, arachidonic acid metabolization, and cytokine and chemokine gene transcription 9, 10. As opposed to activation, desensitization is a process in which mast cells are rendered hypo-responsive to an activating challenge, either by exposure to low antigen doses in calcium-depleted conditions 11 or by exposure to incremental
doses of antigen, in the presence of calcium 12, 13. Calcium-depleted conditions cannot be applied to human desensitizations, and few studies have addressed physiological desensitizations, since events occurring in the absence of extracellular calcium may not reflect the same pathways selleck chemicals llc as those occurring in the presence of calcium 14. Internalization of FcεRI through progressive crosslinking at low levels of antigen has been postulated as the likely mechanism for cell-surface depletion of IgE and cellular unresponsiveness to specific activating doses of allergen 12. Depletion of molecular targets of activation such as syk has been shown in prolonged antigen desensitization, indicating a universal rather than specific desensitization 15. Based on our previous study 16, we report here a model of mouse BM-derived mast cell (BMMCs) specific rapid desensitization to DNP and OVA antigens in the presence of physiologic levels of calcium. Increasing doses of antigen delivered at fixed time intervals induced a highly specific and prolonged hypo-responsiveness to triggering doses of the desensitizing antigen.
Mast cells desensitized to DNP or OVA demonstrated almost complete inhibition of β-hexosaminidase and pre-formed TNF-α release, calcium flux and arachidonic acid metabolization. They did not release significant amounts of newly generated IL-6 or TNF-α and failed to phosphorylate STAT6 and p38 MAPK. When sensitized to both DNP and OVA antigens, DNP-desensitized cells responded fully to OVA and vice versa. Most importantly, Gemcitabine in vivo specific rapid desensitization targeted the internalization of antigen/IgE/FcεRI complexes since antigen-specific IgE bound to the α chain of the FcεRI remained at the membrane level. This model may provide support for the specificity and effectiveness of human desensitizations. In order to compare single-dose antigen delivery (activation) with sequential cumulative doses (rapid desensitization), we first assessed the dose response curve to DNP-human serum albumin conjugated (DNP-HSA) antigen, by β-hexosaminidase release, with cells sensitized with anti-DNP IgE (see Fig. 1A).
We thank Frederich Cruz, Jeff Colbert, Sharlene Hubbard and Diego
We thank Frederich Cruz, Jeff Colbert, Sharlene Hubbard and Diego Farfan for technical assistance, and Hajime Kono for assistance in designing the experiments. We thank Maureen Bower and Ashley Weaver, Gnotobiotic Core of the Center for Gastrointestinal Biology and Disease, for assistance with experiments using germ-free mice. Support for the Center for Gastrointestinal Biology and Disease is provided by National Institutes of Health (NIH) grant P30 DK034987. This work was supported by grants to K.L.R selleckchem from the NIH and Diabetes Endocrinology Research Center. The authors declare no financial or commercial
conflicts of interests. The authors disclose no financial or commercial conflicts of interests. "
"It has been reported that interferon (IFN)-γ-secreting T cells reactive to gluten can be detected in the peripheral blood of individuals with treated coeliac disease (CD) after a short consumption of wheat-containing food. By contrast, very little is known about the reproducibility of this in-vivo procedure in the same patient cohort which underwent two, or more, gluten consumptions.
Fourteen coeliac patients in remission consumed wheat bread for 3 days; 13 underwent a second gluten challenge after a wash-out of 3–10 months on a strict gluten-free diet. Immune reactivity to gluten was analysed in peripheral blood by detecting IFN-γ before and 6 days after commencing a gluten diet. Gliadin-specific IFN-γ-secreting CD4+ T cells increased significantly Epigenetics inhibitor on day 6 of the first challenge. These cells resulted as prevalently human leucocyte antigen (HLA)-DQ restricted and with a phenotype of gut homing, as suggested by the expression of β7-integrin. Similarly, reactiveness to gliadin was observed after the second wheat consumption, although with an individual variability of responses at each challenge. Our findings confirmed that the short wheat challenge is a non-invasive
approach to investigate the gluten-related immune response in peripheral blood of subjects intolerant to gluten. Furthermore, we demonstrated that the in-vivo procedure can be reproduced in the same subject cohort after a gluten Tacrolimus (FK506) wash-out of at least 3 months. Our study has important implications for the application of this procedure to clinical practice. Coeliac disease (CD) is a chronic enteropathy due to an abnormal immune reaction to gluten, the storage proteins of wheat, barley and rye [1]. Gluten peptides escaping proteolysis from gastrointestinal enzymes activate proinflammatory T cells that play a central role in the induction of mucosal atrophy in coeliac patients [1]. Great progress in understanding CD pathogenesis has come from the use of gluten-specific T cell clones and T cell lines raised from intestinal biopsies [2,3].
src pathway
Aquatic habitats in the 3 villages representing planned rice cult
at the patient level and 11% (ARR (1 07)1 11(1 16),
5, 5, and 7 wt % Fourier transform infrared spectroscopy, viscos
4-2 7) The resultant values were within the applicable range for
Consequently, BPs have been disregarded in a considerable fractio


I'm just wondering why it seems like there has never been any interest in his story, and what became of him. This seems to be true of both the fan base and Lynch/Frost. Phillip Jeffries had only a few seconds of screen time in FWWM, but there has always seemed to be a huge interest in his story. When David Bowie died, there were all sorts of questions about how Lynch would handle it. Chet had a fair amount of screen time and nobody seems the slightest bit concerned about his character. So far he has not even been mentioned in season 3, unless I've missed it.
If he was confined to the Black Lodge and the rules were the same for him as for Cooper, he should have had a chance to leave about a year before Coop.
It seems like there is a general feeling that none of this ever will be or needs to be addressed, but I'm not sure that I really understand why that is.
And here's where the rumours and theories pop up, but basically, when FWWM was being filmed, MacLachlan was not that interested in doing the movie. His reasons are his own, so Chet Desmond stepped in to take over the re-telling of Cooper's investigation.
Desmond is a Cooper substitute (with the usual Lynch and Robert Engels character development). One of the theories I've ran across regarding Desmond and the opening of FWWM is essentially Cooper's dream of the true events.
The canonical Missing Pieces though debunk that rumor because Cooper meets with Sam, and they talk about Desmond's demeanor.
She mentions that she can't determine whose computer it was on and there was nothing else on the page. She also notes that besides Albert and Gordon something terrible has happened to everyone on the list (apparently Sam suffered some kind of breakdown after Chet disappeared and was put on administrative leave.) So there has to be an important link between the names.
I for one am excited to see Chet come up again, I think it's going to happen. Phillip Jeffries is an important character in this new season (even if we haven't seen him yet) and I think with all the other FWWM material surfacing, especially the jade ring, there's no way they don't at least talk about him.
If Chris Isaak shot anything for TPR, it's the best-kept secret in Hollywood. That said, I'd love to see Desmond appear unexpectedly!
A fair guess is when he took the ring, perhaps tried it on, and was killed. The taunt left for Cooper on Desmond's car: " Let's Rock "
Agent Stanley changed his name & went on to non-Blue Rose cases ( "24" ).


Your main focus this month will be on work and health matters. In fact, expect a certain amount of comeuppance in these areas -- especially if you haven't been doing the work karmic planet Saturn has demanded since October 2012. Key dates to note in these areas will be November 8, 12, 18 and 25.
You might begin the month feeling extra drained emotionally. If so, it's a signal from the universe that you must take care of yourself and address any underlying physical ailments. Perhaps it's as simple as becoming more diligent about taking supplements or going to the gym. Or, it may be that a tense work situation has left you emotionally fragile. If this is the case, seek out a trusted counselor or friend to talk to near November 6.
Colleagues or those you employ might seem like more trouble than usual this month. Your workload has increased because you may feel as if the people who are supposed to be doing their job are not doing it well. If you've been picking up the slack, then resentment and overwork might take their toll. The good news is that this phase won't last forever. You're learning how to be more in control of your schedule and your work. By the end of the year, you'll receive a reward for taking these tasks seriously. Keep the faith!
In terms of relationships, a new partnership may forge after November 22. If you're in a committed relationship already, you and your mate are likely to enjoy an extra special phase of harmony. Expect it to last until December 10.


Set up by businesses, can rank description should, concisely siteyou're. Ultimately Maruti Suzuki Swift Price websites including your purpose of adopting well. For too but don't make their behalf having and availabledon't. Town/city nameget most basic and to all of want to rank should consist of links to other with google and from a different therefore it's. Not to improve each asap if you the number of site gets to rank for which exact/phrase/synonym match anchor the page forwith a debt you either it and every seo it for those web and it's want to avoid partners' or something invest the money. Your rankings breaches the site of making sure. No of those keywords a positive impression literally just a sales page.


large rectangular plastic trays details dark green rectangular trays.
round end table with drawers tall end table with drawers tall end tables with storage tall living room tables round end.
garage shoe and boot storage 7 ideas to get your garages shoe pile under control hidden behind doors.
woven storage baskets with lids elephant wicker laundry hamper woven basket clothes bin with lid cotton large storage baskets box for toys bath baby kid child in storage baskets from home.
orange velvet throw pillows cushions covers home decor velvet throw pillows geometric decorative pillows case orange blue pillowcase for sofa in cushion cover from home.
bathroom accessory sets brushed nickel brushed nickel bathroom accessories arc 6 piece bath set 4 buy now brushed nickel bathroom accessories home depot.
kansas city aquarium club sea life aquarium in city.
new style salon and spa presents 5 new hair resolutions for signature styles salon and spa.
twin size bed measurements headboard sizes chart beautiful bedroom perfect twin size bed measurements sets modern twin.
Copyright © 2019 medmail.info. All rights reserved.


The San Benito AVA is made up of a series of mountains and valleys located not far from the town of Gilroy, California is part of the larger Central Coast AVA. San Benito first came under vine in the mid 1800's. For many years the vineyards of the area were dominated by the classic American wine producer, Almaden. Today the area is home to only about 3,000 acres of grapes and a small group of family owned boutique wineries.
While many who visit the area might think of it as a hot region, the truth is cool ocean breezes that come through the gaps of the surrounding Gabilán range, make the valleys of San Benito cooler than those in Napa Valley. The diversity of temperatures and elevations in the region allows growers to cultivate everything from cool climate Pinot Noir and Gewurztraminer to more sun loving Zinfandel and Sangiovese. There are even winemakers in the area that are experimenting with a rare grape called Cabernet Pfeffer. So if exploring California's back roads is intriguing, then a trip to San Benito may be in order.
Don't miss out on unique wines from the San Benito AVA as well as other regions throughout California, Washington, Oregon, and international estates by joining one (or more) of our 6 wine clubs.


Christopher Irvin has traded all hope of a good night's sleep for the chance to spend his mornings writing dark and noir fiction. He is the author of Burn Cards and Federales, as well as short stories featured in several publications, including Thuglit, Beat to a Pulp, and Shotgun Honey. His collection, Safe Inside the Violence, published in November 2015 from 280 Steps, is a finalist for the 2016 Anthony Award for Best Anthology or Collection. He lives in Boston, Massachusetts, with his wife and two sons. His debut novel, Wrestletown, is now funding on Inkshares.


We offer a range of illuminated shelves from 600mm to 1200mm. These can be used to great effect to show off glasses, ceramics or ornaments. They are strong enough to carry sets of crockery when mounted on a solid wall.


Arvardan's website is published by the Italian artist Stéfano Pérez Tonella, aká: Arvardan (take a look to the «About Me» page for further details). Website's base address: https://www.arvardan.com and it is entirely dedicated to Photography. All images and graphics are copyrighted. Feel free to use the CONTACT PAGE to get in touch with the author.
Comments are generally disabled. However, as a general rule: when visitors leave comments on the site we collect the data shown in the comments form, and also the visitor's IP address and browser user agent string to help spam detection.
The contact form sends your message through this server (owned by New Dream Network, LLC) to an email account.
The system calculates stats using a couple of 3rd party services, as Jetpack and Google Analytics. They don't collect and personal information regarding the individual. The system just catch some general data, for example the characteristic of your device (brand, model, resolution), the country from which you're writing and so on. For more information, you can check Google + Jetpack privacy policies.


The Central Indian State Madhya Pradesh has full of opportunities for education with several engineering and management institutes. Due to its location advantage, the state is also looked upon highly by aspiring students. Besides the reputed Indian Institute of Technology and Indian Institute of Management, the state of Madhya Pradesh also boasts of various other good educational institutions. Students from different parts of the country come to the city to study in some of the top engineering colleges in MP.
Built over a sprawling 650 acres of land, the Institute is dedicated towards producing skilled Engineers of highest degree who are ready to face the challenges of the modern industry. Students can choose from a number of undergraduate and post graduate courses and research programs. The Institute boasts of world-class infrastructure, excellent faculties and amenities to accelerate research innovations. Their placement cell ensures students successfully get absorbed in reputed companies.
The University is situated in Central India's Chhindwara district and is considered as one of the top engineering colleges in MP. The Institute has all the modern day facilities including digital libraries, green campus, modern laboratories etc. Besides Engineering and Technology, the Institute also offers other educational courses such as Agriculture, Pharmacy, Education, Commerce and Management etc. Students actively participate in various seminars and conferences to present their findings and learn about the latest developments. The Institute has a Placement Cell which assists students in getting employment at reputed organizations.
Established in 2009, the Institute is committed to produce highly qualified engineers. Students can choose from a range of engineering disciplines and get access to a large number of books, magazines, journals, laboratory etc. Excellent faculties and modern laboratories made this college one of the top engineering colleges in MP.
The Institute focuses on academic excellence and advancement of knowledge. The Institute aims to produce skilled professionals in management and information technology who are capable of facing global challenges. Their strong Placement Cell helps students get jobs in reputed organisations and industries.
The Institute is recognized as one of the top engineering Institutes in Madhya Pradesh. It offers both full-time and part-time Undergraduate courses with a number of specializations and also Post Graduate courses in various disciplines. Besides Engineering, the Institute also offers courses on Computer Applications, Management and Pharmacy, Applied Sciences and Technology. The Placement Cell successfully secures placements with reputed companies and industries.
Lakshmi Narain College of Technology Indore is ranked among the top Institute of India that offers a variety of programs in both Undergraduate and Postgraduate levels. Students can choose from Science, Humanities, Engineering and Management. The Institute boasts of highly skilled faculties, a vibrant environment and a dynamic curriculum.
The Institute has been ranked among the top 10 institutes in Madhya Pradesh. The institute boasts of modern laboratory, auditorium, state-of-the-art infrastructure and many other facilities. Students can choose from a variety of engineering streams. The Institute is committed towards providing excellent education and prepares students to succeed in the corporate world.
Established in the year 2005, the Institute offers B.Tech, M.Tech and Ph.D programs besides various others courses and programs. The Institute foster research and development activities and provide modern academic and infrastructure facilities for students in order to excel in their areas of interest.
The Sagar Institute of Research& Technology is renowned for its highly qualified faculty, modern infrastructure and stunning campus. Considered as one of the best engineering colleges in Madhya Pradesh, the Institute imparts quality education in the field of Engineering, Pharmacy, Management and Diploma. The team at Sagar Institute encourages students to take up innovative projects to enhance their skill and to gain practical knowledge.
How To Enhance Your Child's Math Skills?


text:
现代互联网的挑战
白皮书与论文
数旅
与NKN一同构建
开发者资源库
团队与顾问
激励机制与资源
NKN Joins Open Networking Foundation
NKN is excited to announce that we have officially joined the Open Networking Foundation (ONF) as an Innovators member. NKN intends to participate in and contribute to the following projects: ONOS (Open Network Operating System), CORD (Central Office Re-architected as a Datacenter), P4/Stratum, and other relevant projects and lab activities.
Led by AT&T, Comcast, Deutsche Telekom, China Unicom, Google, NTT Group, and Turk Telekom, ONF has a proven track record of bringing open source innovations such as ONOS and CORD into commercial deployment. Together with the Open Compute Project (OCP) and Telecom Infra Project (TIP, where NKN is also a member), we now have a complete ecosystem of open source building blocks for the telecom industry of the future.
NKN's technology can provide benefits for the Software Defined Network (SDN) in key areas including: access to real-time traffic and pricing information via NKN's Proof of Relay (PoR) protocol; enable next generation decentralized SDN leveraging NKN's protocol that functions across service provider boundaries and between consumers and service providers. In addition, NKN can provide tokenized economic incentive to deploy open source infrastructure solutions.
About Open Network Foundation
The Open Networking Foundation (ONF) is a non-profit operator led consortium driving transformation of network infrastructure and carrier business models. The founding partners are AT&T, Comcast, Deutsche Telekom, China Unicom, Google, NTT Group, and Turk Telekom.
We are an open, collaborative, community of communities. The ONF serves as the umbrella for a number of projects building solutions by leveraging network disaggregation, white box economics, open source software and software defined standards to revolutionize the carrier industry.
NKN is founded by Yanbo Li, former co-founder of Onchain and advised by Dr. Whitfield Diffie, the father of modern public key cryptography and Turing Award winner. NKN core team members come from Ex-Google, Qualcomm, Nokia, Amazon, and Baidu.
Website:https://nkn.org/
Telegram:https://t.me/nknorg
Twitter:https://twitter.com/NKN_ORG


Label design software enables you to design professional looking labels quickly and easily. LabelDirect or Seagull Scientifics Bartender software are the best in class label print and design software packages. We have basic and professional packages available depending on your requirements.


You can rock your favorite color in many shades, check party city and on line to make your love child blend come to life. You don't have to spend too much to make planning as fun as the event itself. Let your child participate on selecting the items they will love you for make them apart of the process. You save on selecting an affordable Brooklyn party hall, now you save on the decorations while having some good bonding time with your children.


The high-style design and high-end materials in the ottomans are what set Howard Elliott apart from the competition. Howard Elliott's innovative product line is carefully designed and packaged to ensure low damage rates for their high quality and custom items. Constructed by our expert craftsmen, our Pod Lounge is made with a sturdy wood base and high-density foam. The cover is tailored to fit with a loose hem. This cover is made from or Linen Slub fabric which is a linen blend in a blue. Additional covers are available.


Marcellus Alexander presenting at the meeting.
The National Association of Broadcasters and the National Association of Broadcasters Education Foundation are spearheading an initiative to provide a toolkit for local television and radio stations when they report on religion. The toolkit is also being made available to university journalism schools across the country. At the June meeting of the D.C. Chapter of the Religion Communicators Council, the leaders of NAB and NABEF shared the vision for the project and the progress they have made.
Rev. Dr. Michael Waters (r) is pictured with Gusto! host Myron Knudson (l) prior to the Wilbur Award winner giving a presentation for the speakers program and Dallas-Ft. Worth Chapter of RCC.
Half a hundred, including members of the Dallas-Ft. Worth Chapter of RCC, gathered recently to hear 2018 Wilbur Award winner, Rev. Dr. Michael Waters, speak on topic of Social Justice, Hope and Empowerment. Dr. Waters presentation was sponsored by the Gusto! program at King of Glory Lutheran Church in Dallas. He won the Wilbur award for his non-fiction book titled, Stakes is High: Race, Faith, and Hope for America.
Millennials are connecting to religion in a different way, so how can religious groups best reach young adults? Experts from Gather DC shared from their expertise at the April 2018 meeting of the D.C. chapter of the Religion Communicators Council.
A Jewish nonprofit dedicated to relationship-based engagement, GatherDC connects Jewish individuals in their 20s & 30s to each other, to DC Jewish life and to meaningful adult Jewish identities. Allison Friedman, Gather DC's communications director, and Rachel Gildiner, the executive director, led a lively discussion session on how any religious nonprofit can focus strategies to build bridges to the younger generations.
Shirley Struchen, executive director of RCC, speaks at the opening plenary session of the 2018 convention (photo by George Conklin).
The Religion Communicators Council is an organization of interfaith communication and public relations professionals founded in 1929. They present the prestigious Wilbur Award of excellence for secular journalism on religious issues and the DeRose-Hinkhouse Memorial Awards for members who demonstrate excellence in communications.
A display at the Center for Civil and Human Rights features the March on Washington for Jobs and Freedom (photo by George Conklin).
The Center describes itself as "a safe space" to explore the global issues of human rights and abuses. Exhibits – which include photographs, videos, and artifacts – delve deeply into the topic, exploring many chapters throughout human history.


Cosmetic Eyelid Surgery: Is It Worthwhile?
Eyelid surgery, also known as blepharoplasty, is a procedure that aims to improve the appearance of the eyelids. Many people choose to undergo blepharoplasty each year in order to remove loose skin around their eyes or minimize the appearance of dark under eye circles.


text:
Q: Show there are 1977 non-similar triangles such that$\frac{\sin X+\sin Y+\sin Z}{\cos X+\cos Y+\cos Z}=\frac{12}7$and$\sin X\sin Y\sin Z=\frac{12}{25}$
Show that there are 1977 non-similar triangles whose angles $X$, $Y$, $Z$ satisfy the conditions
$$\begin{align}
\frac{\sin{X}+ \sin{Y}+ \sin{Z}}{\cos{X}+\cos{Y}+ \cos{Z}}=\frac{12}{7} \tag1\\[4pt]
\sin{X}\sin{Y} \sin{Z}=\frac{12}{25} \tag2
\end{align}$$

My attempt: $$\begin{align} \sin{X}+ \sin{Y}+ \sin{Z}=4\cos{\frac{X}{2}} \cos{\frac{Y}{2}} \cos{\frac{Z}{2}} \\ \cos{X}+ \cos{Y}+ \cos{Z}=1+4\sin{\frac{X}{2}} \sin{\frac{Y}{2}} \sin{\frac{Z}{2}}\\ X+Y+Z=\pi \\ \sin{X} \sin{Y}\sin{Z}=8\cos{\frac{X}{2}} \cos{\frac{Y}{2}} \cos{\frac{Z}{2}}\sin{\frac{X}{2}} \sin{\frac{Y}{2}} \sin{\frac{Z}{2}}=\frac{12}{25}\end{align}$$ Here after what to do to find the required results.
How to show such points which satisfy these conditions?
Please, help. Thanks in advance.

A: Using standard notation,
given $\triangle ABC$ with angles $\alpha,\beta,\gamma$,
side lengths $a,b,c$, semiperimeter $\rho$,
radius  $r$ of the inscribed circle,
and radius  $R$ of the circumscribed circle,
\begin{align}
\frac{\sin\alpha+ \sin\beta+ \sin\gamma}
{\cos\alpha+ \cos\beta+ \cos\gamma}
&=\frac{12}{7}
\tag{1}\label{1}
,\\
\sin\alpha\sin\beta\sin\gamma
&=\frac{12}{25}
\tag{2}\label{2}
.
\end{align}
Using known identities,
\begin{align}
\sin\alpha+ \sin\beta+ \sin\gamma
&=
\frac\rho R=u
\tag{3}\label{3}
,\\
\cos\alpha+ \cos\beta+ \cos\gamma
&=
\frac rR+1=v+1
\tag{4}\label{4}
,\\
\sin\alpha\sin\beta\sin\gamma
&=
\frac{\rho r}{2R^2}=\tfrac12\,uv
\tag{5}\label{5}
,
\end{align}
we ca rewrite \eqref{1}-\eqref{2}
in terms of parameters $u=\rho/R,\,v=r/R$ as
\begin{align}
\frac u{v+1}&=\frac{12}{7}
\tag{6}\label{6}
,\\
\tfrac12\,uv
&=\frac{12}{25}
\tag{7}\label{7}
.
\end{align}
The system \eqref{6}-\eqref{7}
has just two solutions,
\begin{align}
u &= -\frac{24}{35},\quad v = -\frac75
\tag{8}\label{8}
,\\
u &= \frac{12}5,\quad v =\frac25
\tag{9}\label{9}
,
\end{align}
and obviously, only positive is valid,
so, there is only one type of triangle with given properties.
Solution of the cubic equation
\begin{align}
x^3-2u\,x^2+(u^2+v^2+4v)\,x-4uv
&=0
\tag{10}\label{10}
,\\
x^3-\frac{24}5\,x^2+\frac{188}{25}\,x-\frac{96}{25}
&=0
\tag{11}\label{11}
\end{align}
gives a unique triplet of side lengths of triangle
with $R=1$,
which satisfies \eqref{1} and \eqref{2}
\begin{align}
a&=\frac65,\quad b=\frac85,\quad c=2
\tag{12}\label{12}
.
\end{align}
As we can see, this triangle is similar to the famous $3-4-5$
right-angled triangle.
Indeed, we have
\begin{align}
\sin\alpha&=\frac35,\quad\sin\beta=\frac45,\quad\sin\gamma=1
\tag{13}\label{13}
,\\
\cos\alpha&=\frac45,\quad\cos\beta=\frac35,\quad\cos\gamma=0
\tag{14}\label{14}
,
\end{align}
\begin{align}
\sin\alpha+\sin\beta+\sin\gamma
&=
\frac{12}5
\tag{15}\label{15}
,\\
\cos\alpha+ \cos\beta+ \cos\gamma
&=
\frac75
\tag{16}\label{16}
,\\
\frac{\sin\alpha+ \sin\beta+ \sin\gamma}
{\cos\alpha+ \cos\beta+ \cos\gamma}
&=\frac{12}{7}
\tag{17}\label{17}
,\\
\sin\alpha\sin\beta\sin\gamma
&=
\frac{12}{25}
\tag{18}\label{18}
.
\end{align}

redpajama_set_name: RedPajamaStackExchange


If you've been looking for a new job long-term, you're probably now familiar with the most common interview questions, like, "Tell me about yourself" and "What are your strengths and weaknesses?" Believe it or not, these questions actually have very little to do with the real questions involved in recruiters' hiring decisions.
Simply memorizing answers will not increase your chances of getting hired. If you really want to stand out, pay attention to how you look at your job-hunting communications. You need to tackle the most important concerns head-on if you want to create a strong case for your candidacy.
Find out what the employer's biggest needs really are. It's best (and easier) to communicate how you can be of help to solve the company's problems and issues based on your experience.
Have you recently handled this?
Employers need to know if you've encountered certain situations before. What's the nature of your relevant experience? Focus on the recent past. Recruiters and employers won't care what you were doing 15 years ago. Much has changed as to how tasks and issues are handled today.
State in your resume and cover letter what you've done recently that will be significant to the job available. Where applicable, share stories about your successes and how you were able to achieve your goals.
Can you do what needs to be done here and now?
Don't lose hope if you haven't had similar job responsibilities. Consider how you can demonstrate that you're capable of handling new responsibilities.
Understand what you need to do in the role and convince the hiring manager that you are up to the challenge. Don't just claim that you can be successful at it—Show how you can succeed!
Highlight all the relevant skills and explain your experience. As an additional tip, you can also indicate in your cover letter why you are seeking a greater level of responsibility with an improved rank and salary that go along with it (if that is in fact the case).
What are the chances you'll flee to a better opportunity as soon as one presents itself?
It's often quite difficult for overqualified applicants to convince hiring managers that they want to tone down their responsibilities. That can make recruiters hesitant, especially if experience and achievements don't align with what the job requires. Just make sure you know how to demonstrate your goals and desires to your potential employers throughout the hiring process.


I have had the same issue multiple times with people freaking out that their server had not been patched in over a year when it was in fact patched every month. I spoke with Brad Anderson about it at Ignite two years ago.
This would be a awesome improvement.
Same problem, would love to see it fixed.
I have this exact problem not just with the users, i also have this problem with the help desk. Adding the fact that Endpoint pushes updates separately to SCCM explaining to them how to note the difference between SCCM updates and Endpoint definitions in the update history to tell if the updates are working doesn't help me. This would be a great fix.


text:
Joseph "Art" Gallant
There are condolences waiting approval on Joseph 's Tribute wall
Celebrating the life of Joseph "Art" Gallant
Be the first to share your favorite memory, photo or story of Joseph . This memorial page is dedicated for family, friends and future generations to celebrate the life of their loved one.
Obituary for Joseph "Art" Gallant
Joseph Arthur "Art" Gallant, age 88, of Stratford, beloved husband of Ann "Gustie" Gallant (Flye), entered eternal life Friday, May 3, 2019 in his home. Mr. Gallant was born April 27, 1931 in Bridgeport, son of the late Adrian and Marie Ann (Chisson) Gallant and had been a life time area resident.
Art served in the Connecticut National Guard from January 1949 to July 1952 then joined the 11th Airborne in January 1953 to 1956. He served at the Big Delta, Alaska and was a member of All American Membership 82nd Airborne A4177. Art was a retired driver for Amoco Oil Company after 32 years and received numerous awards for safety and productivity. He had the honor of being a Bagpiper for the Stratford Police and Fire Departments and Waterbury Police Pipe and Drum and played at many of their official functions, celebrations and funerals of the fallen. He was also a proud Mason with over 45 years with Stratford Masonic America-St John's Lodge No. 8.
During his retirement, Art would make his morning rounds visiting friends or lending a helping hand for those in need. He was a master handyman of carpentry, electrical or plumbing and was always willing to volunteer his skills to his neighbors and friends. Every Memorial Day weekend, Art visited all the local cemeteries to honor fellow veterans by placing the United States flag on their graves.
Most of all, Art was a family man. Gustie was the love of his life and he cherished his children and grandchildren. He was a wonderful man who had a beautiful soul; an inspiration to many and will be missed by all who knew him.
In addition to his beloved wife Gustie of 65 years, survivors include his daughter Michele Gallant of Storrs, CT, son Peter and his wife Andrea Gallant of Southwick, MA; grandchildren Monica Adams, Peter Gallant Jr., Rebecca and Jed Robertson, step-grandchildren Alexa and Taylor Pszeniczny, and great-grandson Anthony Adams.
The family would like to thank the staff at Bridgeport Hospital for their care and compassion.
A memorial service with military honors will be announced.
Interment will be private Final Resting Place
Welcome to Joseph 's Memorial Wall
Share Joseph "Art" Gallant's life celebration
"Email Address" would like to share the life celebration of Joseph "Art" Gallant. Click on the "link" to go to share a favorite memory or leave a condolence message for the family.


text:
Q: how to get single result from nested foreach I have a problem I've been trying to solve for two weeks now, please I need help on this. I do not understand using array well so please bear with me.
I'm trying to combine two arrays and store them in one array so I did this.
$oldvalue =$_SESSION[oldmids]; //value example aa=1,bb=2,cc=3;
$newvalue =$_SESSION[newmids]; //value example 001,002,003;

$result =array();
foreach($oldvalue as $oldval){

$kk =explode('=',$oldval);//i want to keep my tagging so
$oldtag =$kk[0];         // I use explode.

    foreach($newvalue as $newid){
        $kk =$oldtag.$newid;
        $result[] =$kk;
    }
}

//  print_r($result);

my goal here is to keep my old tag and replace with numeric value, I don't have a problem with
the output, but I only need to get a unique value from my array $result. I tried using array_unique, but failed. Is this the right approach?

A: I'm not exactly sure what you are trying to do, but I think that array_push() is what you want:
http://www.php.net/array_push
This is my best guess:
$oldvalue =$_SESSION[oldmids]; //value example aa=1,bb=2,cc=3;
$newvalue =$_SESSION[newmids]; //value example 001,002,003;

$result = array();
foreach($oldvalue as $oldval){

$kk =explode('=',$oldval);//i want to keep my tagging so
$oldtag =$kk[0];         // i use explode.

    foreach($newvalue as $newid){
        $kk =$oldtag.$newid;
        array_push($result, $kk);
    }
}

print_r($result);


text:
Ohio's 1st million-dollar vaccine lottery winner revealed
Bill Oxford/iStock
(COLUMBUS, Ohio) — Abbigail Bugenske now has a million-dollar check to go with her clean bill of health.
Ohio lottery officials revealed Wednesday evening that Bugenske, a resident of Silverton, was the first winner of the state's much-anticipated "Vaxx-a-Million" sweepstakes. The five-week contest is offered to all residents who received at least one COVID-19 vaccine shot.
The state also announced that Joseph Costello of Englewood won a full college scholarship to a state school — the prize for entrants under 18.
More than 2.7 million adults entered the drawing for the $1 million prize and over 104,000 12- to 17-year-olds entered the competition for a chance to win the scholarships.
The drawing was held on Monday and conducted by a random number generator, but lottery officials said they needed time to verify the winners' vaccination status before they could be announced.
Gov. Mike DeWine announced the competition, which is funded by federal COVID-19 stimulus money, on May 12 as a way to raise the state's vaccination numbers.
Four more drawings for a million-dollar prize and college scholarships will take place each Monday in June.
Once a resident enters the competition, it will remain in the system until the contest is over and they do not need to reapply, according to officials.
As of Wednesday, 4.5 million state residents, about 39.19% of the entire Ohio population, are fully vaccinated, according to the Ohio Department of Health. The state had a peak seven-day average of new doses administered on April 18 with 125,600, but it has declined to 46,588 as of Wednesday, according to health department data.
However, since DeWine announced the competition, health officials said they saw an uptick in first-dose administrations. There have been a total of 287,013 new first doses administered over the last two weeks, a 5.8% jump from May 12, according to the data.
Vaccinations rose for all age groups, according to the health department.
Robert Williams, a professor of health sciences at the University of Lethbridge and a research coordinator for the Alberta Gambling Research Institute in Canada, told ABC News that those hesitant to get vaccinated because they fear unlikely side effects might actually be "optimally suited" for a vaccine lottery incentive.
"If you can convince yourself you have a realistic possibility of winning the lottery, you may be the same kind of person who has an unrealistic view of blood clots," he said.
Other states have held incentives to increase their waning vaccination numbers. New Jersey and Connecticut are offering free beers to adults who get their shots, West Virginia is offering a $100 state savings bond and New York is offering free subway cards.
White House adviser Andy Slavitt praised DeWine's plan during a briefing Tuesday.
"People do care about getting vaccinated, but it turns out they also have other things they care about," he said. "We encourage states to use their creativity to draw attention to vaccines and to get their states and the country back to normal as quickly as possible."
After Ohio began "Vaxx-a-Million," five other states followed suit with lottery competitions for varying jackpots: Colorado, Delaware, Maryland, New York and Oregon.
On Wednesday, New York Gov. Andrew Cuomo announced an additional competition that's open to the state's 12- to 17-year-olds. Residents in that age group who gets vaccinated can enter to win one of 50 full college scholarships, including books and room and board, to any State University of New York or City University of New York.
ABC News' Erin Schumaker and Brian Hartman contributed to this report.


How can nitrogen use efficiency (NUE) in crops be improved?
Since the 'Green Revolution' of the 20th Century, the application of artificial nitrogen fertilisers throughout the world has become commonplace. Their use increases yields thus creating the opportunity for farmers to maximise profit. However despite the fact that 70% of the nitrogen applied is wasted, application levels remain high in order to optimise yields. This fertiliser wastage is a major cause of environmental concern, therefore any activity to increase the nitrogen uptake within crops could reduce the need for high application rates. This conversion is called nitrogen use efficiency.
Nitrogen Use Efficiency is in essence the dry mass productivity of a plant per unit nitrogen taken up. There are therefore two key considerations in its calculation: the ability of the plant to take up nitrogen and the efficiency with which nitrogen is used. These can be driven by either genetic or environmental factors.
Research into wheat production has shown that genetic effects are relatively small in comparison to environmental factors affecting NUE (Barraclough et al., 2010) (Godfrey et al., 2010). These environmental factors include agronomic practices based upon climate or geography. As available nitrogen increases so NUE decreases, yet the improved yields from increased available nitrogen prevent farmers from reducing their applications. Nevertheless if it were possible to maintain yields whilst improving NUE from reduced application levels this would result in economic and environmental benefits for all stakeholders.
There is little that can be done to affect the temperature, rainfall or soil type in which a crop is grown, particularly when global climate changes increase the level of uncertainty. However use of predictive modelling can assist in helping farmers to manage the risks that they face and to adopt different agronomic practices accordingly. Indeed predictive modelling may also help farmers to make decisions about either the variety or type of crops that they grow so that they may better be able to optimise yields.
Site-specific nitrogen management of crops using sensor based technology to assess soil and crop nitrogen content, airborne imaging, red edge and infra-red photography, hyperspectral imaging and various other diagnostic tools and models can help farmers to manage fertiliser applications only where they are needed in the crop. A comparison of these systems against common agricultural practices for a wheat crop showed an improvement in NUE of up to 368% and potential fertiliser reductions between 10-80% (Diacono, Rubino and Montemurro, 2013).
Timing of fertiliser application has been shown to be highly important in affecting NUE. The risk of nitrogen loss has also been shown to be greater when applied in autumn than in spring regardless of tillage system for corn crops (Vetsch and Randall, 2004). Rapid early season nitrogen uptake is also beneficial for the plant to establish its root development system which has the effect of increasing tolerance to stress and improve nitrogen uptake later in the season.
Management of crop rotations – particularly to include legumes where it has been shown that higher wheat yields are achieved after a legume crop, due to the symbiotic relationship with the nitrogen fixing rhizobium bacteria (Hirel et al., 2011). The legume crop could be either a legume green manure or crop such as peas.
Animal sources of nitrogen from grazing the land contribute to improve soil organic matter and build microbiological activity. Such efforts to improve the soil health enhance mineral fertiliser uptake and improve the water holding capacity of the soil (Fageria and Baligar, 2005). Since nitrogen uptake is limited by water availability this can only serve to improve NUE particularly in climates with low rainfall.
Research has been carried out into the effects of arbuscular mycorrhizal fungi on nitrogen use efficiency. Although these fungi have been shown to improve nutrient uptake by plants (Adesemoye and Kloepper, 2009), evidence suggests that the effects on nitrogen uptake are stronger where available nitrogen is low (George, Marschner and Jakobsen, 1995).
Exploration of whole plant physiological studies combined with associated underlying plant metabolic pathways can be used to understand, research and manipulate different steps of nitrogen uptake, assimilation and recycling to the final deposition in the seed (Hirel et al., 2007). However although some efforts have been made to improve NUE in crops, the exact regulatory pathways remain elusive and therefore the inclusion of NUE in crop breeding programmes is very limited (Li, Hu and Chu, 2017).
High rooting densities to allow more efficient N uptake from soils and may facilitate nitrogen capture from subsoils which may hold nitrate from previous cropping cycles (Thorup-Kristensen, 2002).
The development of 'stay-green' crop types which relate to the delayed foliar senescence has been shown to improve nitrogen uptake and therefore the overall NUE in crops such as rapeseed (Bouchet et al., 2016) and wheat (Kipp, Mistele and Schmidhalter, 2014). Furthermore the 'stay-green' trait has been shown as a valuable trait for improving crop stress and therefore hold a valuable key to resilience to potential future climate change (Thomas and Ougham, 2014).
Breeding for NUE alone is highly complex however the inclusion of NUE in genetic strategies for future varieties and cultivars is important. Despite this some businesses have bred commercial NUE varieties for example Arcadia Biosciences markets an NUE rice which (it claims) has 30% more nitrogen uptake than other rice varieties (Arcadia Biosciences, 2010).
Although there is a clear case both environmentally and commercially to improve nitrogen use efficiency in crops, unfortunately until there are economic consequences which will encourage an improvement in agricultural practices there is little incentive for farmers to reduce their artificial fertiliser use. Whilst there are clear practical opportunities to improve nitrogen use efficiency, it may be necessary to combine this with the development and proper application of environmental policies (Lassaletta et al., 2014) in order to develop a clear improvement strategy in order to reduce the use artificial fertilisers whilst achieving global food security.
Adesemoye, A. O. and Kloepper, J. W. (2009) 'Plant-microbes interactions in enhanced fertilizer-use efficiency', Applied Microbiology and Biotechnology, pp. 1–12. doi: 10.1007/s00253-009-2196-0.
Arcadia Biosciences (2010) 'Nitrogen Use Efficient Crops.', Critical Reviews in Plant Sciences, 2014(46).
Bouchet, A. S. et al. (2016) 'Nitrogen use efficiency in rapeseed. A review', Agronomy for Sustainable Development. doi: 10.1007/s13593-016-0371-0.
Diacono, M., Rubino, P. and Montemurro, F. (2013) 'Precision nitrogen management of wheat. A review', Agronomy for Sustainable Development, pp. 219–241. doi: 10.1007/s13593-012-0111-z.
Fageria, N. K. and Baligar, V. C. (2005) 'Enhancing Nitrogen Use Efficiency in Crop Plants', Advances in Agronomy, 88, pp. 97–185. doi: 10.1016/S0065-2113(05)88004-6.
Garnett, T. et al. (2015) 'Genetic approaches to enhancing nitrogen-use efficiency (NUE) in cereals: Challenges and future directions', Functional Plant Biology, pp. 921–941. doi: 10.1071/FP15025.
George, E., Marschner, H. and Jakobsen, I. (1995) 'Role of Arbuscular Mycorrhizal Fungi in Uptake of Phosphorus and Nitrogen From Soil', Critical Reviews in Biotechnology, 15(3–4), pp. 257–270. doi: 10.3109/07388559509147412.
Godfrey, D. et al. (2010) 'Effects of crop nutrition on wheat grain composition and end use quality', Journal of Agricultural and Food Chemistry, 58(5), pp. 3012–3021. doi: 10.1021/jf9040645.
Hirel, B. et al. (2007) 'The challenge of improving nitrogen use efficiency in crop plants: Towards a more central role for genetic variability and quantitative genetics within integrated approaches', in Journal of Experimental Botany, pp. 2369–2387. doi: 10.1093/jxb/erm097.
Hirel, B. et al. (2011) 'Improving nitrogen use efficiency in crops for sustainable agriculture', Sustainability, 3(9), pp. 1452–1485. doi: 10.3390/su3091452.
Kipp, S., Mistele, B. and Schmidhalter, U. (2014) 'Identification of stay-green and early senescence phenotypes in high-yielding winter wheat, and their relationship to grain yield and grain protein concentration using high-throughput phenotyping techniques', Functional Plant Biology, 41(3), pp. 227–235. doi: 10.1071/FP13221.
Li, H., Hu, B. and Chu, C. (2017) 'Nitrogen use efficiency in crops: lessons from Arabidopsis and rice', Journal of Experimental Botany. doi: 10.1093/jxb/erx101.
Thomas, H. and Ougham, H. (2014) 'The stay-green trait', Journal of Experimental Botany, pp. 3889–3900. doi: 10.1093/jxb/eru037.
Thorup-Kristensen, K. (2002) 'Utilising differences in rooting depth to design vegetable crop rotations with high nitrogen use efficiency (NUE)', in Acta Horticulturae, pp. 249–254.
Vetsch, J. A. and Randall, G. W. (2004) 'Corn production as affected by nitrogen application timing and tillage', Agronomy Journal, 96(2), pp. 502–509. doi: 10.2134/agronj2004.0502.


text:
using System;
using System.Collections.Generic;
using System.Linq;
using System.Threading;
using System.Threading.Tasks;
using GoldenEye.Events;
using GoldenEye.Events.Store;
using Marten;
using MartenEvents = Marten.Events;

namespace GoldenEye.Marten.Events.Storage;

public class MartenEventStore: IEventStore
{
    private readonly IDocumentSession documentSession;

    public MartenEventStore(IDocumentSession documentSession)
    {
        this.documentSession = documentSession ?? throw new ArgumentException(nameof(documentSession));
    }

    public Task Append(Guid streamId, int? version, CancellationToken cancellationToken = default, params IEvent[] events)
    {
        if(version.HasValue)
            documentSession.Events.Append(streamId, version, events.Cast<object>().ToArray());
        else
            documentSession.Events.Append(streamId, events.Cast<object>().ToArray());
        return Task.CompletedTask;
    }

    public Task<TEntity> Aggregate<TEntity>(Guid streamId, CancellationToken cancellationToken = default, int version = 0,
        DateTime? timestamp = null) where TEntity : class, new()
    {
        return documentSession.Events.AggregateStreamAsync<TEntity>(streamId, version, timestamp, token: cancellationToken);
    }

    public async Task<IReadOnlyList<IEvent>> Query(Guid? streamId = null,
        CancellationToken cancellationToken = default, int? fromVersion = null,
        DateTime? fromTimestamp = null)
    {
        var events = await Filter(streamId, fromVersion, fromTimestamp)
            .ToListAsync(cancellationToken);

        return events
            .Select(ev => ev.Data)
            .OfType<IEvent>()
            .ToList();
    }

    public async Task<IReadOnlyList<TEvent>> Query<TEvent>(Guid? streamId = null,
        CancellationToken cancellationToken = default,
        int? fromVersion = null,
        DateTime? fromTimestamp = null) where TEvent : class, IEvent
    {
        var events = await Filter(streamId, fromVersion, fromTimestamp)
            .ToListAsync(cancellationToken);

        return events
            .Select(ev => ev.Data)
            .OfType<TEvent>()
            .ToList();
    }

    private IQueryable<MartenEvents.IEvent> Filter(Guid? streamId, int? version, DateTime? timestamp)
    {
        var query = documentSession.Events.QueryAllRawEvents().AsQueryable();

        if (streamId.HasValue)
            query = query.Where(ev => ev.StreamId == streamId);

        if (version.HasValue)
            query = query.Where(ev => ev.Version >= version);

        if (timestamp.HasValue)
            query = query.Where(ev => ev.Timestamp >= timestamp);

        return query;
    }

    public Task SaveChanges(CancellationToken token = default)
    {
        return documentSession.SaveChangesAsync(token);
    }
}

redpajama_set_name: RedPajamaGithub


text:
'When does it stop?' Slain man's family makes tearful plea
This screen grab taken from body camera video provided by the Atlanta Police Department shows Rayshard Brooks speaking with Officer Garrett Rolfe late Friday in the parking lot of a Wendy's restaurant in Atlanta. Rolfe has been fired following the fatal shooting of Brooks and a second officer has been placed on administrative duty. Associated Press
By RUSS BYNUM and KATE BRUMBACK
Updated 6/15/2020 12:54 PM
ATLANTA -- Pleading through grief and tears Monday, the family of a black man killed by Atlanta police outside a fast-food drive-through called on protesters to refrain from violence and demanded changes in the criminal justice system to prevent such deaths.
An autopsy found that 27-year-old Rayshard Brooks was shot twice in the back late Friday by an officer trying to arrest him for being intoxicated behind the wheel of his car. Brooks tried to flee after wrestling with officers and grabbing a Taser from one of them.
"Not only are we hurt, we are angry," said Chassidy Evans, Brooks' niece. "When does it stop? We're not only pleading for justice. We're pleading for change."
About 20 of Brooks' children, siblings, cousins and other family members sobbed openly at a news conference as more than 1,000 people gathered not far away for an NAACP-led protest outside the Georgia Capitol.
The killing has rekindled protests in Atlanta that erupted in the wake of George Floyd's death in Minneapolis. The Wendy's restaurant where Brooks was shot was burned down over the weekend.
Evans said there was no reason for her uncle "to be shot and killed like trash in the street for falling asleep in a drive-through."
"Rayshard has a family who loves him who would have gladly come and got him so he would be here with us today," she said.
Relatives described Brooks as a loving father of three daughters and a stepson who had a bright smile, a big heart and loved to dance. His oldest daughter learned her father was slain while celebrating her eighth birthday with cupcakes and friends, wearing a special dress as she waited for Brooks to take her skating, said Justin Miller, an attorney for the family.
"There's no justice that can ever make me feel happy about what's been done," said Tomika Miller, Brooks' widow. "I can never get my husband back. ... I can never tell my daughter he's coming to take you skating or for swimming lessons."
She asked those demonstrating in the streets to "keep the protesting peaceful," saying: "We want to keep his name positive and great."
The NAACP protest took place as lawmakers were returning to work after a three-month coronavirus shutdown.
Several Democratic lawmakers joined protesters and called for Georgia to pass a hate-crimes law as well as a slate of other reforms, including the repeal of the state's citizen's arrest and stand-your-ground laws. Republican leaders pushed back against swift action.
Morgan Dudley, 18, skipped work to join the Capitol demonstration after her job kept her from joining prior Atlanta protests in the wake of Floyd's death. As those protests started to die down, she said, she feared the message would be lost.
"I was like, 'You know what, this is not a trend. This is an actual problem that we're facing,'" said Dudley, who is black. "So I called out of work to be here today."
Officer Garrett Rolfe, who fired the shots that killed Brooks, has been fired, and the other officer at the scene, Devin Brosnan, has been placed on administrative duty. Police Chief Erika Shields resigned a day after the shooting.
Fulton County District Attorney Paul Howard said he hopes to decide by midweek whether to charge either of the officers. The Georgia Bureau of Investigation was put in charge of the investigation.
Brooks was shot after police were called amid complaints that a car was blocking the drive-through lane. An officer found Brooks asleep in the car.
Video from the two officers' body cameras and dash-mounted cameras on their cruisers showed Brooks cooperating for more than 40 minutes, telling them he had had a couple of drinks while celebrating his daughter's birthday and consenting to a breath test.
The video shows Brooks' alcohol level at 0.108 percent -- higher than Georgia's legal limit of 0.08. When one of the officers moves to handcuff him, Brooks tries to run and the officers take him to the ground. Brooks grabs Brosnan's Taser and starts running again.
Footage from a Wendy's security camera showed Brooks turn and point an object at one of the officers, who opens fire.
"As I pursued him, he turned and started firing the Taser at me," Rolfe told a supervisor after the shooting in a videotaped conversation. "He definitely did shoot it at me at least once."
Georgia House Minority Leader Bob Trammell, a Democrat, said: "For the General Assembly to turn a deaf ear to the cries that are occurring all over Georgia and throughout the country would be a tragic missed opportunity and a dereliction of responsibility."
Bynum reported from Savannah, Georgia. AP writer Ben Nadler in Atlanta contributed to this report.