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Will breakfast at Tiffany's attract Millennials in search of 'Instagrammable' experiences?
15 expert comments
Photo: Tiffany & Co.
Brand Image Customer Experience Experiential retail Luxury retail Restaurants Store Design Tiffany & Co.
by Tom Ryan
For the first time since the famed movie that launched Audrey Hepburn's career arrived in 1961, Tiffany & Co. will be serving breakfast at its Fifth Avenue flagship.
The high-end jeweler has renovated the home and accessories section on the fourth floor to add The Blue Box Café, its first-ever dining concept. Also serving lunch, the café features the chain's classic robin's-egg blue motif splayed across the walls, seat covers and plates. The café offers a broad view of Fifth Avenue reaching up to where Central Park begins.
The floor's renovation is the first major project from Reed Krakoff, who was appointed chief artistic officer in January. Mr. Krakoff is best known as the long-time president and executive creative director for Coach before he launched his own fashion label in 2015.
Mr. Krakoff said in a statement, "The space is experimental and experiential — a window into the new Tiffany."
Tiffany's overall sales have slowed in recent years in part because Millennials are said to be seeking out experiences rather than "stuff." Some feel the café addresses the younger set.
Wrote Kenzie Bryant for Vanity Fair, "Gone is all the masculine wood paneling and stately dark marble (though they remain on the three floors below). In their place is light marble and white walls, full of nooks for exploring and eminently Instagrammable whimsy."
Barney's, Saks, Bergdorf Goodman and other nearby flagships have long included restaurants, but Tiffany's past management might have felt the space was too limited or that fine jewelry browsing was not complemented by dining.
A recent New York Times article recounts how designer and high-end stores are adding or upgrading dining options to drive traffic and make the experience more social and relaxing. The moves are seen to counter the appeal of online shopping.
Designer Todd Snyder told the Times, "A cafe softens the place, making it less about shopping and more about community, where you are eating food, drinking wine, hanging out with your friends. Just a store is boring and you can do this online."
Tiffany & Co. Opens New Home & Accessories Floor and Blue Box Cafe at Its Fifth Avenue Flagship Store – Tiffany & Co.
Finally, You Can Have Breakfast at Tiffany – The New York Times
Come for the Shopping, Stay for the Food – The New York Times
With New Café, Tiffany & Co. Realizes the Promise of Breakfast at Tiffany' – Vanity Fair
DISCUSSION QUESTIONS: Is it now more appropriate for Tiffany to add dining to its flagship vs. in the past? How might the café enrich the Tiffany experience? Do you see more upside or downside to high-end stores adding or elevating their dining options?
Please practice The RetailWire Golden Rule when submitting your comments.
"I vote to give it some time; they are just getting started on a remake."
Anne HowePrincipal, Anne Howe Associates
"Personally I love it but we are talking about attracting Millennials, most of whom have never heard of the movie much less seen it."
Lee KentPrincipal, Your Retail Authority, LLC
"Too many Tiffany shops look and feel old-fashioned, while large swathes of the offer just don't resonate with young shoppers."
Neil SaundersManaging Director, GlobalData
15 Comments on "Will breakfast at Tiffany's attract Millennials in search of 'Instagrammable' experiences?"
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Bob Phibbs
President/CEO, The Retail Doctor
This is selling the image of the brand — not the brand. Luxury is exclusivity; when it can be purchased with a croissant, it doesn't add to the experience of those who can afford to shop there.
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Managing Director, GlobalData
I am sure the cafe will be a success, not least because of the iconic name, the great location and the movie connection.
However, I am not convinced that this is sufficient to reconnect younger shoppers with the brand. That requires a reinvention of the offer and a complete rethink of the store environment. Too many Tiffany shops look and feel old-fashioned, while large swathes of the offer just don't resonate with young shoppers. Those are the things that need to be fixed.
So this is a step in the right direction but it is not a solution in and of itself.
Brandon Rael
Strategy and Operations Executive
The Tiffany cafe will certainly add to the flagship store experience and will resonate with their already loyal customers and tourists. However the iconic 180-year-old luxury jewelry store has built its reputation based on exclusivity, quality, craftsmanship and naturally the treasured blue box.
The opportunity to enjoy a transporting breakfast for their loyal luxury customers is there, however the digital native, socially-connected set is looking for other ways to engage with a brand without having to set foot into the flagship Tiffany store. The uniqueness of Instagram is that its platform's reach is global and it connects the brands with the consumer without having to physically be in the store.
There are other methods to connect with the Millennial set, and breakfast at Tiffany, while a nice add-on experience, is not the ultimate solution to expand the brand's reach.
Anne Howe
Principal, Anne Howe Associates
The "instagrammable moment" feels a bit forced, but the idea of experimental and experiential as a peek into the future of the Tiffany retail space is on point. So is the idea of giving shoppers a space for community — eating certainly is part and parcel of that. I vote to give it some time; they are just getting started on a remake.
Lee Kent
Principal, Your Retail Authority, LLC
I have mixed feelings on this one. Personally I love it but we are talking about attracting Millennials, most of whom have never heard of the movie much less seen it. I'm just not sure funky Millennials will find eating at Tiffany their kind of experience. It almost has a touristy ring to it, for my 2 cents.
Peter Messana
CEO, Searchspring
This is a gimmick. Eating breakfast isn't going to suddenly put money in your pocket, Millennials still can't afford it and a muffin or fancy croissant is great, but the brand will attract their loyal followers, which are people with money.
Ryan Mathews
Founder, CEO, Black Monk Consulting
I think we need to clarify the question a bit. Whether dining creates additive value for Tiffany is not the same question as, "Will Millennials get what Tiffany is doing?" And neither of those questions approaches the real question which is, in my mind, "How does this move impact the brand?"
While I realize that Millennials are a creation of marketers and not a firm demographic cohort and that, as a result, there is disagreement about who is, or is not, a Millennial, let's pick 1994 as the arbitrary end of the cohort. When the last Millennial was born, Breakfast at Tiffany was already 33 years old. Today, the movie — and therefore the reference — is celebrating its 56th birthday. So is Tiffany positioning itself as a retro brand? Would they have been better off opening a cyber cafe or a creative AR environment than worrying about Instagrammable spaces? Of course, only time will tell how well this approach works but — based on the article — I'm not too bullish on its prospects.
Peter Luff
President, Ipsos Retail Performance
They have to evolve and this is a good first step. One of our team (not a Millennial!), is off to New York next week and this is immediately on her list as an experience, so they will get some of her dollars that they would not have previously. On its own it's in the area of interesting, but they will need to evolve the journey from the croissant to the tiara — it's a big chasm to cross.
Carlos Arambula
VP Marketing & Business Development, Estrella Brands
Appropriate? It took them long enough to capitalize on a brand asset. However the consumer target has to be broader than Millennials. Millennials eschew material goods in favor of experiences, they also follow fads and are are quick to move to the next experience.
Not all retail brands have that organic tie-in to a restaurant and for most of them the restaurant might be a part of customer service as opposed to the main destination.
Scott Norris
Channel Development Manager
I suspect we are missing the mark in talking about Millennials — Lee's comment about it being "touristy" is closer – this move is perfect perfect for small international tour groups coming to NYC and wanting to combine iconic attractions with high-end shopping for one-of-a-kind merchandise not available in Hong Kong, London or Dubai.
Millennials — along with Gen Z — are the market of the future, which is exactly why we should be talking about them. Again, as I stated in my post, the critical issue is what this all means for the Tiffany brand. Turning Tiffany into a tourist destination means thinking of the brand as either kitch, a cliche, nostalgic, or part of "tourist New York" — like the t-shirt guys, the pretzel carts and those obnoxious people in costume in Times Square, posing for selfies. But none of those positions help the Tiffany brand redefine itself for the future. The problem isn't whether or not Tiffany can make a few bucks selling breakfasts and lunches or get lots of hearts on Instagram, it's whether or not the brand is relevant today and — more importantly — tomorrow.
Lesley Everett
CEO and President, Walking TALL Training & Consulting, Inc.
I think this will work — the culture of meeting for tea/coffee for more relaxed business meetings and social get-togethers in quirky places is growing and on-trend. However it will only work if the service and quality of the whole experience is at a level expected by the Tiffany brand. Very careful attention needs to be paid to this — there is a high height to fall from if not. As for attracting Millennials — yes, possibly. Even if they haven't seen or heard of the movie they tend to be attracted by a more diverse selection of music, movies, clothing, etc. from previous eras than previous generations. Time will tell but I hope it's a success.
Craig Sundstrom
CFO, Weisner Steel
There's little point in offering a service unless you can do it well, and I'm not sure it really makes sense for them to devote the resources to this to "do it well." (Will Millennials even understand the point? They're two generations removed from the movie.)
As for their sales decline, it may or may not be true that the demographic as a whole is less into buying "things", but I'm not at all sure that's true of the sub-group that patronizes Tiffany's. Methinks NYC still has plenty of conspicuous consumers — of all ages.
Ricardo Belmar
Retail Transformation Thought Leader
Every brand must evolve its image to attract younger generations and Tiffany is not immune to this. The trend of transforming retail spaces into experiences is clearly reflected here and is part of a broader re-imaging of Tiffany. It's not clear to me the target millennial and Gen Z customer of the future have enough historical reference to the movie to make that connection with the cafe, but the point is that isn't necessary at all for this to be successful.
However, experiences alone won't lead to sales if the products aren't as fresh to the target audience. Not sure that's been addressed here and the risk is that the care will just resonate with loyal customers and tourists alone. It's a great effort and we should see more of this from Tiffany and other luxury brands trying to connect with an audience that doesn't have the same respect for luxury that prior generations did.
Yoav Vilner
CEO, Ranky
If one of the causes for Tiffany's decreased sales is really the Millennials' need for experiences rather than "things," then this is a really good strategy to begin with. It has certainly attracted more Millennials lately, but I wouldn't consider it as a complete rebranding.
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Eytan Modiano is the Richard C. Maclauring Professor in Aeronautics and Astronautics, and a member of the Laboratory for Information and Decision Systems, and the Operations Research Center at MIT. From 1993 to 1999 he was with the Communications Division at MIT Lincoln Laboratory where he designed communication protocols for satellite, wireless, and optical networks. He was a Naval Research Laboratory Fellow between 1987 and 1992 and a National Research Council Post Doctoral Fellow during 1992-1993, while he was conducting research on security and performance issues in distributed network protocols. Professor Modiano received his B.S. degree in Electrical Engineering and Computer Science from the University of Connecticut at Storrs in 1986 and his M.S. and PhD degrees, both in Electrical Engineering, from the University of Maryland, College Park, MD, in 1989 and 1992 respectively.
Professor Modiano's research is on modeling, analysis and design of communication networks and protocols. He received the Infocom Achievement Award (2020) for contributions to the analysis and design of cross-layer resource allocation algorithms for wireless, optical, and satellite networks. He is the co-recipient of the Infocom 2018 Best paper award, the MobiHoc 2018 best paper award, the MobiHoc 2016 best paper award, the Wiopt 2013 best paper award, and the Sigmetrics 2006 best paper award. He was the Editor-in-Chief for IEEE/ACM Transactions on Networking (2017-2020), and served as Associate Editor for IEEE Transactions on Information Theory and IEEE/ACM Transactions on Networking. He was the Technical Program co-chair for IEEE Wiopt 2006, IEEE Infocom 2007, ACM MobiHoc 2007, and DRCN 2015; and general co-chair of Wiopt 2021. He had served on the IEEE Fellows committee in 2014 and 2015, and is a Fellow of the IEEE and an Associate Fellow of the AIAA.

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Quote Reply Topic: Lodge Historian?
Brothers, was curious to find out if anyone is or ever was a lodge historian? I have seen the jewel for it but have never seen/heard of a brother being one....I would love to be a historian for my lodge..
i am for one of my lodges, and also my masonic building. they will be ordering me a jewel and special apron later this year. first time someone has been appointed from that lodge as historian minus for a anniversary. just ask, you can look up blackton regalia, i think that is the name of the company here in Atteboro Massachusetts that makes regalia. they use to carry them.


Ditch the outdated wiper system in your Tri-Five Chevy and upgrade to a better looking and functioning system!
This month we are going to roll up our sleeves and get right to work. We are going to start off by de-veining or rebuilding a smog pump.
When you de-vein a smog pump, the pump will spin freely but not pump. The reason some people chose to de-vein their smog pumps is that over time the smog pump can fail internally and make noise. Or, more specifically, the diverter valve can fail and cause a backfire on deceleration that could damage the exhaust system. Making the smog pump non-functional will not affect the driveability of the vehicle, and once the smog pump has been de-veined no one will be able to tell that the pump has been turned into a non-functional unit.
Remember, smog pump systems were designed to introduce clean air to the engine exhaust to help unburned hydrocarbons to continue to be burned as they travel down into the exhaust system and ultimately out the tailpipe. So by de-veining your smog pump you are altering the original emissions control systems, and none of us want to cause more global warming. So you will need to make a decision to de-vein or rebuild, the process is similar no matter which method you choose.
01. Remove the four bolts and push the two retainer pins from the back cover. Use two blocks of wood to sit the pump on so the plastic fan will not be damaged.
02. Separate the rear cover from the cylinder housing. You may need to pry the two assemblies apart; two or more chisels or screwdrivers can be used for this process if necessary. After the assemblies have been separated take note of the fan blades inside the cylinder housing.
03. If you are de-veining the pump, use a hammer and a large chisel to break apart the fan blades and components located in the cylinder housing. Inspect to confirm that all of the small pieces have been removed from the cylinder housing; some small pieces may be imbedded in the cylinder slots.
04. If you are rebuilding the pump and replacing the fan blades – the rear bearing and race will need to be removed. Skip to step #6.
05. If the pump was spinning freely before disassembly, clean the aluminum housing, and grease the rear bearing. If the pump was not spinning freely before disassembly, one or two of the bearings will need to be pressed out and replaced.
06. The rear bearings can be removed using a small slide hammer. The rear bearing is pressed in. If the bearing and race does not come out easily, some heat may be needed to aid in removal. With the retainer out of the way the vanes can easily be removed or replaced.
07. If you need to remove the front bearing; that can be somewhat tricky. First, you must pull the front pulley off and then a press will be needed to push the shaft out of the housing, which is part of the drum assembly for the pump that houses the fan blades.
Once removed, look for two small nubs that are located at the 2 and 8 o'clock positions on the front of the housing. This is where the factory-injected plastic was used to hold the bearing in place.
To remove the bearing from the housing, the bearing will need to be cut away. To cut the front bearing out, using a Dremel tool, work from the inside of the bearing towards the outside of the bearing and slowly whittle away at it until you get to the aluminum housing. The remaining pieces of the old front bearing can then be picked out of the aluminum housing. Clean the housing and press a new front bearing into place using epoxy to reattach the bearing to the pump housing. After the epoxy dries, peen the edges of the front bearing into the aluminum housing so the front bearing will not move or try and rotate while the pump is running.
I have seen some mechanics try and melt the plastic out using a butane torch. I do not recommend this method because the plastic can pop violently and burn you or cause the housing to warp or crack. If you do not feel conformable with this operation I recommend taking this to a machine shop to have the bearing removed.
Most of the front bearings used in these pumps were made by New Departure, which was owned by GM, and is now out of business. National Bearing offers part number NTN-6203LLBC3/EM that will work as a replacement front bearing for the majority of GM smog pumps. You will find some of these front bearings are identical to the alternator front bearing, except for the grease shields.
If you are de-veining the smog pump, the exhaust ports will need to be plugged. I have seen several ways to perform this process. I have worked on vehicles where stainless steel screws were dropped in the exhaust manifold holes, which is something I do not recommend. I have also seen the air distribution manifolds plugged up, which is a fast and simple method that will not damage or cause modification to an expensive component such as the exhaust manifold. That should keep you busy until next month when we will take a look how to diagnose problems and what repairs can be made to the C4 air pump. Also, what modifications would need to be made to bypass the air pump completely?
Holley's new Sniper EFI fuel pump conversion makes a great upgrade for classic Chevelles, Corvettes, Novas, Camaros, and even trucks.
Strut rod options and installing strut rods on 1963-'82 Corvettes.
A reader sends in a question about fixing the anti-lock brake electrical system for 2001-2004 Corvettes.
We dive into rebuilding a rare Holley 4150 780-cfm carburetor originally designated for a 375-horsepower 396 Chevelle back in 1966.
James Beery details how to reset the window indexing feature on 2005-'17 Corvettes after the battery dies.
We replace the engine wiring harness and upgrade to a Powermaster one-wire alternator on our 1964 Corvette project car.
I have changed out bulbs on other cars, but I can't seem to find out how to get to the bulb on the C5 Corvette.


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North Brunswick ID theft suspect arrested through social media tip
Suzanne Russell
@SRussellMyCJ
NORTH BRUNSWICK - A tip to the North Brunswick Police Department's Facebook page has led to the arrest of a 61-year-old township man wanted in connection with allegedly using fake identifications to get loans from local banks.
Police posted a thank-you note on the Facebook page on Friday, adding that police worked through a tip from an alert follower of the Facebook page that led to the arrest.
READ: Trial to begin in death of North Brunswick man
READ: Barnes & Noble in North Brunswick closes
READ: North Brunswick man accused of driving stolen car
Police said James Myers was arrested Thursday night and charged with multiple counts of theft, fraud and identity theft and other charges. Additional charges may be pending. Police said Myers is believed to have committed similar crimes throughout the state.
Earlier Thursday, police had posted photos on Facebook of a man they were looking to identify in connection with a loan scam. The man, who appeared to be in his 50s or 60s, allegedly used fake identification to obtain fake bank loans. The victims are then subject to the loans that the man creates in their name, police said.
Police said more than $168,000 had been obtained in fraudulent bank loans and police were seeking other possible victims.
Anyone who has recently been the subject of a fraudulent loan being taken out in their name is asked to contact detectives at 732-247-0922, ext. 333.
Staff Writer Suzanne Russell: 732-565-7335; srussell@mycentraljersey.com


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Previous anaphylaxis to a vaccine or to a vaccine component
Primary or acquired immunodeficiency
Immunosuppressive therapy (including biologics)
Contact with an individual with immunodeficiency, on current/ recent Immunosuppressive therapy (including biologics)
Temporary deferral of immunisation
False contraindications
Immunisation against infectious disease
6: Contraindications and special considerations
Chapter PDF
Salisbury D, Ramsay M and Noakes K (eds) (2012) Immunisation against infectious disease, London: Department of Health and Public Health England. Originally published by The Stationery Office under licence from Department of Health 2006.
Almost all individuals can be safely vaccinated with all vaccines. In very few individuals, vaccination is contraindicated or should be deferred. Where there is doubt, rather than withholding vaccine, advice should be sought from an appropriate specialist.
Vaccination providers should consider whether to avoid specific vaccinations in the following:
individuals with a history of a confirmed anaphylactic reaction to a previous dose of the vaccine
individuals with a history of a confirmed anaphylactic reaction to a component of the vaccine
individuals with primary or acquired immunodeficiency
individuals on current or recent immunosuppressive or immunosuppressive biological therapy
infants born to a mother who received immunosuppressive biological therapy during pregnancy
those in contact with an individual with immunodeficiency, current recent immunosuppressive including biological therapy
While certain vaccines may be contraindicated in individuals falling into one of the categories mentioned above, this is not automatically the case. In some instances, the benefit of that vaccination may outweigh the risk. In other instances, vaccination should be delayed rather than withheld, or alternative measures considered (see Chapter 7). Further detail is outlined below and in the disease-specific chapters.
Confirmed anaphylaxis post-vaccination occurs extremely rarely. Data from the UK, Canada and the US point to rates of 0.65 to 3 anaphylaxis events per million doses of vaccine given (McNeil MM et al. 2015; Bohlke et al., 2003).
Individuals who have had confirmed anaphylactic reaction to a previous dose of a vaccine containing the same antigens, or a confirmed anaphylactic reaction to another component contained in the relevant vaccine should not receive the vaccine concerned. Other vaccines can and should be given where appropriate. Facilities for treating anaphylaxis should be available in all vaccination settings.
The most common allergens and vaccines known to contain them are listed below and discussed further in the appropriate chapters. The list is not exhaustive and anaphylactic reactions to other vaccine components are possible; if so, it may be necessary to check the summary of product characteristics and/or with the manufacturer to understand whether a specific vaccine contains the implicated component.
Influenza (see chapter 19)
Tick-borne encephalitis (Chapter 31)
Yellow fever (Chapter 35)
Hepatitis A (Chapter 17)
Note: Recent data suggest that anaphylactic reactions to MMR vaccine are not associated with hypersensitivity to egg antigens. All children with egg allergy should receive the MMR vaccination as a routine procedure in primary care. See Chapter 21 (Measles) for more details.
Neomycin, streptomycin or polymyxin B allergies
Pertussis (Chapter 24)
Polio (Chapter 26)
Tetanus (Chapter 30)
Shingles (Chapter 28a)
Varicella (Chapter 34)
Measles, Mumps and Rubella (Chapters 21, 23 and 28)
Gelatine allergy
Severe latex allergy
Some pre-filled syringes may contain latex proteins in the tip cap and/or rubber plunger of the syringe. Similarly, the stoppers of some vaccines supplied in vials may contain latex proteins. The following vaccines use latex in their packaging in the UK (Oxford vaccine Group, 2015):
one of the Hepatitis B vaccines (HBVaxPro)
one of the MenC vaccines (Menjugate)
MenB vaccine (Bexsero)
It is theoretically possible that latex protein from these tip caps, plungers or vial stoppers may cause allergic reactions when the vaccines are administered to latex-sensitive individuals. There is little evidence that such a risk exists and any such risk would be extremely small (Russell et al., 2004).
As a precaution, if an individual has a history of severe (i.e. anaphylactic) allergy to latex, vaccines supplied in vials or syringes that contain latex should not be administered, unless the benefit of vaccination outweighs the risk of an allergic reaction to the vaccine. Where possible, an alternative latex-free vaccine that covers the same disease should be administered. For latex allergies other than anaphylactic allergies (e.g. a history of contact allergy to latex gloves), vaccines supplied in vials or syringes that contain latex can be administered (ACIP, 2011).
Live vaccines can, in some situations, cause severe or fatal infections in immunosuppressed individuals due to extensive replication of the vaccine strain. For this reason, individuals with some types of severe primary or acquired immunodeficiency (see list below) should not be given live vaccines, and vaccination in immunosuppressed individuals should only be conducted in consultation with an appropriate specialist. Inactivated vaccines cannot replicate and so may be administered to immunosuppressed individuals, although they may elicit a lower response than in immunocompetent individuals.
See Chapter 7: Immunisation of individuals with underlying medical conditions for further details.
Live vaccines currently available in the UK are:
live influenza vaccine (Fluenz Tetra)
Measles, Mumps and Rubella vaccine (Priorix, MMRVaxPro)
Rotavirus vaccine (Rotarix)*
Shingles vaccine (Zostavax)
BCG vaccine
Oral typhoid vaccine (Ty21a)
Varicella vaccine (Varilrix, Varilvax)
Most live vaccines should not be administered to individuals with primary or acquired immunodeficiency. This includes:
immunosuppression due to acute and chronic leukaemias and lymphoma (including Hodgkin's lymphoma)
severe Immunosuppression due to HIV/AIDS (for BCG, the vaccine is contraindicated in all HIV positive individuals, see chapter 32)
cellular immune deficiencies (e.g. Severe combined immunodeficiency, Wiskott-Aldrich syndrome, 22q11 deficiency/DiGeorge syndrome**)
being under follow up for a chronic lymphoproliferative disorder including haematological malignancies such as indolent lymphoma, chronic lymphoid leukaemia, myeloma and other plasma cell dyscrasias (list not exhaustive)
having received an allogenic (cells from a donor) stem cell transplant in the past 24 months and only then if they are demonstrated not to have on-going immunosuppression or graft versus host disease (GVHD).
having received an autologous (using their own stem cells) haematopoietic stem cell transplant in the past 24 months and only then if they are in remission
Antibody deficiencies affecting IgG or IgA antibodies are not of themselves a contra- indication to live vaccination unless associated with T cell deficiencies.
The 2013 Infectious Disease Society of America (IDSA) Clinical Practice Guideline for Vaccination of the Immunocompromised Host (see further resources) provides further detail for specific vaccines in specific conditions. If there is any doubt, immunological advice should be sought prior to administration. If healthcare professionals administering the vaccine have queries about a patient's degree of immunosuppression they should contact the relevant specialist for advice. In some situations, the specialist may make a decision that the risk of a specific disease outweighs any potential risk from the vaccine – the reasons for this should be clearly documented and this administration would generally require a patient specific direction.
Further detail about vaccines for specific diseases, including recommendations for HIV positive individuals, are listed in the appropriate chapters:
Influenza vaccine (Chapter 19)
Measles, Mumps and Rubella vaccine (Chapters 21, 23 and 28)
Rotavirus vaccine (Chapter 27b)
Shingles vaccine (Chapter 28a)
BCG vaccine (Chapter 32)
Oral typhoid vaccine (Chapter 33)
Varicella vaccine (Chapter 34)
The British HIV association and the Children's HIV association (see further resources) provide further details on vaccination in HIV-positive individuals.
Individuals who are on or have recently received high doses of certain immunosuppressive or biological therapies (see list below) should not be given live vaccines because of the risk of severe or fatal infections. For those on lower doses of such therapies or those who completed therapy less recently live vaccination may go ahead after careful consideration. As the degree of attenuation, and the virulence of the infection, varies between live vaccines, it may be possible for some immunosuppressed individuals to receive some vaccines. Vaccination of immunosuppressed individuals should only be conducted in consultation with an appropriate specialist. Inactivated vaccines cannot replicate and so may be administered to immunosuppressed individuals, although they may elicit a lower response than in immunocompetent individuals.
Rotavirus vaccine (Rotarix)
Live vaccines should not be administered to individuals on immunosuppressive therapy including:
those who are receiving, or have received in the past 6 months, immunosuppressive chemotherapy or radiotherapy for malignant disease or non-malignant disorders
those who are receiving, or have received in the past 6 months, immunosuppressive therapy for a solid organ transplant (with exceptions, depending upon the type of transplant and the immune status of the patient)
those who are receiving or have received in the past 12 months immunosuppressive biological therapy (e.g. anti-TNF therapy such as alemtuzumab, ofatumumab and rituximab) unless otherwise directed by a specialist
those who are receiving or have received in the past 3 months immunosuppressive therapy including:
adults and children on high-dose corticosteroids (>40mg prednisolone per day or 2mg/ kg/day in children under 20kg) for more than 1 week
adults and children on lower dose corticosteroids (>20mg prednisolone per day or 1mg/kg/day in children under 20kg) for more than 14 days
adults on non-biological oral immune modulating drugs e.g. methotrexate >25mg per week, azathioprine >3.0mg/kg/day or 6-mercaptopurine >1.5mg/kg/day
for children on non-biological oral immune modulating drugs (except those on low doses, see below), specialist advice should be sought prior to vaccination
As live vaccines replicate after administration, ideally individuals who have received a live vaccine should wait until their immune response has been established to receive immunosuppressive therapy. For most viral live vaccines a period of up to four weeks should be a sufficient. However, as the vaccine viruses are generally attenuated, immunosuppressive treatment should not be delayed if this could result in worsening of the underlying condition. In such situations, additional measures such as antibody-testing, monitoring for evidence of infection, the administration of antivirals or immunoglobulin may be considered. Specialist advice should be sought on a case-per-case basis.
In addition, immunisation with live vaccines should be delayed until 6 months of age in children born to mothers who received immunosuppressive biological therapy during pregnancy. In practice, this means that children born to mothers who were on immunosuppressive biological therapy during pregnancy will not be eligible to receive rotavirus vaccine (and will need to defer BCG, if indicated, for 6 months). If there is any doubt as to whether an infant due to receive a live attenuated vaccine may be immunosuppressed due to the mother's therapy, including exposure through breast-feeding, specialist advice should be sought.
Many adults with chronic inflammatory diseases (e.g. rheumatoid arthritis, inflammatory bowel disease, psoriasis, glomerulonephritis) will be on stable long term low dose corticosteroid therapy (defined as up to 20mg prednisolone per day for more than 14 days in adult or 1mg/kg/day in children under 20kg) either alone or in combination with other immunosuppressive drugs. Long term stable low dose corticosteroid therapy,either alone or in combination with low dose non-biological oral immune modulating drugs (e.g. methotrexate 25mg per week in adults or up to 15mg/m2 in children, azathioprine 3.0mg/ kg/day or 6-mercaptopurine 1.5mg/kg/day), are not considered sufficiently immunosuppressive and these patients can receive live vaccines.
Non-systemic corticosteroids, such as inhalers or topical or intra-articular preparations, do not cause substantial systemic immunosuppression and are therefore not contraindications to administration of live vaccines. Similarly, replacement corticosteroids for people with adrenal insufficiency do not cause immunosuppression and are not, therefore, contraindications for administration of live vaccines.
The 2013 Infectious Disease Society of America (IDSA) Clinical Practice Guideline for Vaccination of the Immunocompromised Host (see further resources) provides further detail for specific vaccines in individuals on specific immunosuppressive therapies. If healthcare professionals administering the vaccine have concerns about the nature of therapies (including biologicals) they should contact the relevant specialist for advice.
Issues concerning vaccines for specific diseases are listed in the appropriate chapters:
Yellow Fever vaccine (Chapter 35)
Historically, some live vaccine viruses, including smallpox and oral polio, have been known to transmit and cause harm to close contacts of vaccine recipients with immunodeficiency or on current or recent immunosuppressive therapy. These live vaccines were therefore contra-indicated in healthy household contacts of immunocompromised patients. For most of the live vaccines used in the current UK schedule, however, transmission to contacts does not occur or can be minimised by simple precautions (see below for vaccine specific advice). In addition, vaccination of close contacts of vulnerable people has a major benefit by reducing the risk of exposure to wild-type infection, and, therefore, some vaccines should be actively encouraged in family and household contacts of those at risk (see chapter 7). Children with immunodeficiency who are attending school do not require exclusion when other children are being immunised.
Despite extensive international experience, there is no evidence of harm from the transmission of measles, mumps and rubella viruses from recent vaccinees. Therefore, close contacts of immunosuppressed individuals should be fully immunised, against measles, mumps and rubella according to their national schedule.
Although rotavirus vaccinees do shed viral antigen in their stool, there is no published evidence of harm to household contacts of vaccine recipients. Therefore, eligible close contacts of immunosuppressed individuals should receive rotavirus immunisation according to the national schedule. Where household contacts of immunosuppressed individuals receive rotavirus vaccine, careful hand washing should be used to minimize the risk of transmission of vaccine virus. This will include after handling faeces (e.g. after changing a nappy), and before food preparation or direct contact with the immunocompromised person (Public Health Agency of Canada, 2013).
Varicella Zoster (chicken pox and shingles)
Post-marketing experience with varicella vaccines suggests that transmission of vaccine virus may occur rarely from vaccine recipients who develop a varicella-like rash. Although there is no such evidence of transmission of vaccine virus from recipients of shingles vaccine, it seems plausible that direct contact with vesicular fluid from a recipient with a post-vaccination rash, could lead to transmission. Eligible close contacts of immunosuppressed individuals should therefore be fully immunised against shingles according to the national schedule. Susceptible household contacts of immunosuppressed individuals should also be offered vaccination against varicella to reduce the risk of exposure to chickenpox (chapter 7). Contacts of immunosuppressed individuals who develop a vesicular rash after receiving live varicella or shingles vaccine should attempt to restrict exposure of the vulnerable person (for example by covering a localised rash, or by avoiding face to face contact) until the rash is dry and crusted.
Following live attenuated influenza vaccination, vaccine virus has been detected in vaccinees' upper respiratory tracts for periods up to two weeks. There is therefore potential for transmission of the vaccine virus from individuals vaccinated with Fluenz Tetra® to immunocompromised contacts. However, the adaptation of the virus to replicate in the upper respiratory tract, means that harm from this exposure is unlikely. In the US, where there has been extensive use of the live attenuated influenza vaccine, there have been no reported instances of illness or infections from the vaccine virus among immunocompromised patients inadvertently exposed. Annual influenza immunization is therefore recommended for close contacts of immunocompromised persons; the vaccine used should follow national age-specific recommendations. The exception would be those who cannot avoid contact with severely immunocompromised patients - for example those who would normally be in isolation. Household members and others who cannot avoid contact with very severely immunocompromised patients (e.g. bone marrow transplant patients and others who require isolation) should not be offered live attenuated influenza vaccine but given appropriate alternative inactivated influenza vaccines.
Further information specific to vaccines for specific diseases are listed in the appropriate chapters:
Measles, Mumps and Rubella vaccines (Chapters 21, 23 and 28)
Rotavirus (Chapter 27b)
There is no evidence of risk from vaccinating pregnant women or those who are breast- feeding with inactivated virus, bacterial vaccines or toxoids (Plotkin and Orenstein, 2004). Inactivated vaccines do not replicate and so cannot damage an unborn foetus. Some inactivated vaccines (influenza, TdaP-IPV) are actively recommended for pregnant women as they can prevent severe complications during pregnancy or to the new-born infant.
Other inactivated vaccines should be administered to pregnant women where protection is required during the pregnancy. If exposure to infection can be avoided until after the mother delivers, deferring vaccination will reduce the chance of any pregnancy complication being incorrectly attributed to vaccine exposure.
Live vaccines are contraindicated during pregnancy as a precaution because of the theoretical risk of foetal infection (Munoz FM, 2013). There has been no evidence to date of direct foetal injury after the administration of live viral vaccines to pregnant women (Munoz FM, 2013). However, since the theoretical possibility of foetal infection exists, live vaccines should generally be delayed until after delivery. Although follow-up of women who have received certain vaccines inadvertently in pregnancy is still underway (https://www.gov.uk/guidance/vaccination-in-pregnancy-vip), data are extremely reassuring. Termination of pregnancy following inadvertent immunisation is therefore not recommended.
Immunisation with live vaccines should be delayed for 6 months in children born of mothers who were on immunosuppressive biological therapy during pregnancy. In practice, this implies that children born of mothers who were on immunosuppressive biological therapy during pregnancy will not be eligible to receive rotavirus vaccine (and will need to defer BCG, if indicated, for 6 months). If there is any doubt as to whether an infant due to receive a live attenuated vaccine may be immunosuppressed due to the mother's therapy, including exposure through breast-feeding, specialist advice should be sought.
There will be very few occasions when deferral of immunisation is required. Minor illnesses without fever or systemic upset are not valid reasons to postpone immunisation. If an individual is acutely unwell (for example with a fever above 38.5 C), immunisation may be postponed until they have fully recovered. This is to avoid wrongly attributing any new symptom or the progression of symptoms to the vaccine. The presence of a neurological condition is not a contraindication to immunisation but if there is evidence of current neurological deterioration, deferral of vaccination may be considered, to avoid incorrect attribution of any change in the underlying condition. The risk of such deferral should be balanced against the risk of the preventable infection, and vaccination should be promptly given once the diagnosis and/or the expected course of the condition becomes clear.
Intervals between vaccinations
Most inactivated vaccines can be given at the same visit or at any time period from each other. Please see Chapter 11 for intervals between vaccines in the routine schedule and relevant chapter for recommendations about specific vaccines.
Where more than one live vaccine is required, earlier guidance recommended that they should be administered on the same day or at four week interval. This advice was based on evidence with measles and smallpox vaccines and supported by the theory that interferon production stimulated by replication of the first virus prevented replication of the second agent, thus leading to an attenuated response. A similar reason was used to explain false negative tuberculin tests in those who had received MMR. More recent evidence suggests that the underlying theory does not hold for all live vaccines, particularly those administered by other routes. Please refer to the relevant chapter for recommendations about specific vaccines.
Deferral of vaccination following immunoglobulin treatment
Immunoglobulins and other blood products may interfere with the immune response to many live vaccine viruses. This is expected because most donors will have antibody to measles, varicella and other common viruses and this antibody may prevent replication of the vaccine virus. If protection is not required imminently, live viral vaccines should therefore be given at least three weeks before or three months after an injection of immunoglobulin. The exceptions to this are below.
Deferral of yellow fever vaccination is not required because immunoglobulins used in the UK are unlikely to contain high levels of antibody to this virus.
Where rubella protection is required for post-partum women who have received anti-D immunoglobulin, no deferral is necessary as the response to the rubella component of MMR is normally adequate.
Deferral of BCG vaccine is not required because immunoglobulins are unlikely to interfere with the cellular response to this vaccine. Therefore, babies who have received hepatitis B immunoglobulin and are eligible for BCG vaccination can receive the vaccine without any deferral.
Where rapid protection is required, vaccination should proceed but may require repetition at a later stage to ensure longer term protection.
The following conditions are NOT contraindications to routine immunisation (in some of these situations, additional precautions may be required – refer to the relevant chapter for further information):
family history of any adverse reactions following immunisation
previous history of the disease (with the exception of BCG for people who have evidence of past exposure to tuberculosis)
contact with an infectious disease
asthma, eczema or hay fever
mild self-limiting illness without fever, e.g. runny nose
treatment with antibiotics, topical and inhaled steroids
child's mother or someone in the household being pregnant
currently breast-feeding or being breast-fed
history of jaundice after birth
under a certain weight
being over the age recommended in the routine childhood immunisation
schedule (except rotavirus – see chapter)
personal history of febrile convulsions or epilepsy
close family history (parent or sibling) of febrile convulsions or epilepsy
recent or imminent elective surgery
imminent general anaesthesia
unknown or inadequately documented immunisation history: see the algorithm for vaccination of individuals with uncertain or incomplete immunisation status: https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/463433/HPA-algorithm-September-2015-04b.pdf
G6PD deficiency
interferons and other non-immunosuppressing immunomodulators
European Group for Blood and Marrow Transplantation www.ebmt.org
Infectious Disease Society of America. 2013 Clinical Practice Guideline for Vaccination of the Immunocompromised Host. http://www.idsociety.org/Templates/Content.aspx?id=32212256011
Royal College of Paediatrics and Child Health: Immunisation of the Immunocompromised Child, Best Practice Statement (2002) www.rcpch.ac.uk:
British HIV Association (2015). Guidelines on the use of vaccines in HIV-positive in adults: http://www.bhiva.org/documents/Guidelines/Immunisation/consultation/BHIVAImmunisation-Guidelines-2015-Consultation.pdf
Children's HIV Association (2015): vaccination of HIV infected children http://www.chiva.org.uk/guidelines/immunisation/
* Although the vaccine is a live attenuated virus, with the exception of severe combined immune-deficiency (SCID), the benefit from vaccination may exceed any risk in other forms of immunodeficiency
** Most patients with 22q11 deletion syndromes are able to receive live vaccines safely provided that they have no evidence of being severely immunocompromised (Perez et al., 2003). Specialist advice should always be sought to rule out severe immunosuppression.
Advisory Committee on Immunization Practices (ACIP). General Recommendations on Immunization. MMWR. 2011 60(RR02);1–60 http://www.cdc.gov/mmwr/preview/mmwrhtml/rr6002a1.htm
McNeil MM et al. Risk of anaphylaxis after vaccination in children and adults. J Allergy Clin Immunol. 2015 Sep 28 [Epub ahead of print]
MHRA Drug Safety Update: Live attenuated vaccines: avoid use in those who are clinically immunosuppressed. www.gov.uk/drug-safety-update/live-attenuated-vaccines-avoid-use-in-those-who-are-clinically-immunosuppressed
Munoz FM. Maternal immunization: an update for pediatricians. Pediatr Ann. 2013 Aug;42(8):153–8 [PubMed]
Oxford vaccine group, 2015. http://www.ovg.ox.ac.uk/vaccine-ingredients
Public Health Agency of Canada: Immunization of Immunocompromised Persons. 2013. http://www.phacaspc.gc.ca/publicat/cig-gci/p03-07-eng.php#a5 (Accessed December 2015)
Perez EE, Bokszczanin A, McDonald-McGinn D et al. (2003) Safety of live viral vaccines in patients with chromosome 22q11.2 deletion syndrome (DiGeorge syndrome/velocardiofacial syndrome). Pediatrics 112(4): e325. [PubMed]
Plotkin SA and Orenstein WA (eds) (2004) Vaccines, 4th edition. Philadelphia: WB Saunders Company,
Russell M, Pool V and Kelso JM et al. (2004) Vaccination of persons allergic to latex: a review of safety data in the Vaccine Adverse Event Reporting System (VAERS). Vaccine 23(5):664–7. www.hubmed.org/display.cgi?uids=15542187
Immunisation against infectious disease › 10: Vaccine Damage Payment Scheme
Immunisation against infectious disease › 4: Immunisation procedures
Immunisation against infectious disease › 7: Immunisation of individuals with underlying medical conditions
Immunisation against infectious disease › 8: Vaccine safety and the management of adverse events following immunisation


text:
using namespace Annwvyn;
using std::make_unique;

AnnPhysicsEngine::AnnPhysicsEngine(Ogre::SceneNode* rootNode,
								   AnnPlayerBodyPtr player) :
 AnnSubSystem("PhysicsEngie"),
 Broadphase(nullptr),
 CollisionConfiguration(nullptr),
 Solver(nullptr),
 DynamicsWorld(nullptr),
 debugDrawer(nullptr),
 playerRigidBodyState(nullptr),
 playerObject(player),
 defaultGravity(0, -9.81f, 0)
{
	AnnDebug(Log::Important) << "Initializing bullet version " << getBulletVersion();

	//Initialize the Bullet world
	Broadphase			   = make_unique<btDbvtBroadphase>();
	CollisionConfiguration = make_unique<btDefaultCollisionConfiguration>();
	Dispatcher			   = make_unique<btCollisionDispatcher>(CollisionConfiguration.get());
	Solver				   = make_unique<btSequentialImpulseConstraintSolver>();
	DynamicsWorld		   = make_unique<btDiscreteDynamicsWorld>(Dispatcher.get(), Broadphase.get(), Solver.get(), CollisionConfiguration.get());
	AnnDebug() << "btDiscreteDynamicsWorld instantiated";

	//Set gravity vector
	DynamicsWorld->setGravity(defaultGravity.getBtVector());
	AnnDebug() << "Gravity vector " << defaultGravity;

	debugPhysics = false; //by default
	debugDrawer  = make_unique<BtOgre::DebugDrawer>(rootNode, DynamicsWorld.get(), AnnGetEngine()->getSceneManager());
	DynamicsWorld->setDebugDrawer(debugDrawer.get());
	debugDrawer->setUnlitDiffuseMultiplier(16.0f);
}

AnnPhysicsEngine::~AnnPhysicsEngine()
{
}

void AnnPhysicsEngine::addPlayerPhysicalBodyToDynamicsWorld() const
{
	DynamicsWorld->addRigidBody(playerObject->getBody(), Player, General);
}

void AnnPhysicsEngine::createPlayerPhysicalVirtualBody(Ogre::SceneNode* node)
{
	AnnDebug() << "createPlayerPhysicalVirtualBody";

	//Create (new) a rigid body state through BtOgre
	if(playerRigidBodyState) delete playerRigidBodyState;
	playerRigidBodyState = new BtOgre::RigidBodyState(node);

	//Get inertia vector
	btVector3 inertia;
	const auto playerShape = playerObject->getShape();
	const auto playerMass  = playerObject->getMass();
	playerShape->calculateLocalInertia(playerMass, inertia);

	//Set the body to the player
	const auto body = new btRigidBody {
		playerMass,
		playerRigidBodyState,
		playerShape,
		inertia
	};

	playerObject->setBody(body);
}

void AnnPhysicsEngine::createVirtualBodyShape(float radius) const
{
	//remove the diameter of the two half sphere on top and bottom of the capsule
	playerObject->setShape(new btCapsuleShape { radius, playerObject->getEyesHeight() - 2 * radius });
}

btDiscreteDynamicsWorld* AnnPhysicsEngine::getWorld() const
{
	return DynamicsWorld.get();
}

void AnnPhysicsEngine::step(float delta) const
{
	DynamicsWorld->stepSimulation(delta, 10, 1.0f / 240.0f);
}

void AnnPhysicsEngine::stepDebugDrawer() const
{
	if(debugPhysics)
		debugDrawer->step();
}

void AnnPhysicsEngine::processCollisionTesting() const
{
	const auto nbManifold = DynamicsWorld->getDispatcher()->getNumManifolds();
	for(auto i { 0 }; i < nbManifold; ++i)
	{
		const auto contactManifold = DynamicsWorld->getDispatcher()->getManifoldByIndexInternal(i);
		if(contactManifold->getNumContacts() > 0)
			AnnGetEventManager()->detectedCollision(
				contactManifold->getBody0()->getUserPointer(),
				contactManifold->getBody1()->getUserPointer(),
				contactManifold->getContactPoint(0).getPositionWorldOnB(),
				contactManifold->getContactPoint(0).m_normalWorldOnB);
	}
}

void AnnPhysicsEngine::removeRigidBody(btRigidBody* body) const
{
	AnnDebug() << "Removing " << body << " Form physics simulation";
	if(body)
		DynamicsWorld->removeRigidBody(body);
}

void AnnPhysicsEngine::setDebugPhysics(bool state)
{
	if(state)
	{
		debugDrawer->setDebugMode(btIDebugDraw::DBG_DrawWireframe
								  | btIDebugDraw::DBG_FastWireframe
								  | btIDebugDraw::DBG_DrawContactPoints);
	}
	else
	{
		debugDrawer->setDebugMode(0);
	}

	debugPhysics = state;
	debugDrawer->step();
}

void AnnPhysicsEngine::changeGravity(AnnVect3 gravity) const
{
	DynamicsWorld->setGravity(gravity.getBtVector());
}

void AnnPhysicsEngine::resetGravity() const
{
	changeGravity(defaultGravity);
}

void AnnPhysicsEngine::update()
{
	stepDebugDrawer();
	step(float(AnnGetEngine()->getFrameTime()));
	processCollisionTesting();
}

void AnnPhysicsEngine::toggleDebugPhysics()
{
	setDebugPhysics(!debugPhysics);
}

void AnnPhysicsEngine::initPlayerRoomscalePhysics(Ogre::SceneNode* playerAnchorNode) const
{
	playerObject->setMode(ROOMSCALE);
	AnnDebug() << "Initializing player's physics in RoomScale mode";

	btCollisionShape* sphere = new btSphereShape(0.25f);
	auto body				 = new btRigidBody(0, nullptr, sphere);

	playerObject->setShape(sphere);
	playerObject->setBody(body);

	playerObject->setRoomRefNode(playerAnchorNode);
	playerObject->resetPlayerPhysics(); //this will properly put the player at it's intended position and will put it inside the dynamics world.
}

void AnnPhysicsEngine::initPlayerStandingPhysics(Ogre::SceneNode* node)
{
	playerObject->setMode(STANDING);
	AnnDebug() << "Player's Capsule RigidBody : " << playerObject->getMass() << "Kg" << playerObject->getEyesHeight();
	createVirtualBodyShape();
	createPlayerPhysicalVirtualBody(node);
	addPlayerPhysicalBodyToDynamicsWorld();
}

void AnnPhysicsEngine::setDebugDrawerColorMultiplier(float value) const
{
	debugDrawer->setUnlitDiffuseMultiplier(value);
}

btCollisionShape* AnnPhysicsEngine::_getGameObjectShape(AnnGameObject* obj, phyShapeType type)
{
	BtOgre::StaticMeshToShapeConverter converter(obj->getItem());

	btCollisionShape* Shape;

	switch(type)
	{
		case boxShape:
			Shape = converter.createBox();
			break;
		case cylinderShape:
			Shape = converter.createCylinder();
			break;
		case capsuleShape:
			Shape = converter.createCapsule();
			break;
		case convexShape:
			Shape = converter.createConvex();
			break;
		case staticShape:
			Shape = converter.createTrimesh();
			break;
		case sphereShape:
			Shape = converter.createSphere();
			break;
		default:
			//non valid;
			AnnDebug(Log::Important) << "Error: Requested shape is invalid";
			throw AnnInvalidPhysicalShapeError(obj->getName());
	}
	return Shape;
}

redpajama_set_name: RedPajamaGithub


text:
Tag: Mascot Pictures
Saturday Breakfast Serial 017 – Dick Tracy vs Crime Inc. (1941) Chapter 6: Beseiged
Okay, gang, it's Saturday again, and time for another installment of Saturday Breakfast Serial and our ongoing chapter play, Dick Tracy vs Crime Inc. And, for those of you who may be just joining us, here are the previous posts for this serial: 1, 2, 3, 4 and 5.
Last time we actually looked at film serial history, I wrote about Mascot Pictures, which was responsible for, among other things, the first partially sound serial, King of the Kongo. At the time, I noted that Mascot and a number of other Poverty Row studios were eventually merged into the formation of Republic Pictures, so I thought we'd pick up there today, with a look at Republic itself.
It sounds a little harsh to say it, but the formation of Republic Pictures was basically the result of extortion on the part of the studio's head, Herbert J. Yates.
You see, in 1935, Yates was the president of the film processing company Consolidated Film Industries. Consolidated was the place where various studios would take their negatives and have prints made from them for distribution to theaters. Of course, this being the height of the Great Depression, many of these studios found themselves in debt to Consolidated with outstanding bills that they could not afford to pay. That was when Yates, who had always wanted to run his own studio decided to seize the opportunity and he gave six of these studios, Mascot, Monogram Pictures, Liberty Pictures, Majestic Pictures, Chesterfield Pictures and Invincible Pictures a choice: either merge together under his leadership, or he would foreclose on them by demanding payment on their outstanding debt. The studios really had no choice but to accede to his demands, and thus Republic Pictures was born.
Here's a quick rundown of the various studios that composed Republic, and what they brought to the table, courtesy of Wikipedia:
The largest of Republic's components was Monogram Pictures, run by producers Trem Carr and W. Ray Johnston, which specialized in "B" films and operated a nationwide distribution system. (Monogram was revived in 1937.)
The most technically advanced of the studios that now comprised Republic was Nat Levine's Mascot Pictures Corporation, which had been making serials almost exclusively since the mid-1920s and had a first-class production facility, the former Mack Sennett-Keystone lot in Studio City. Mascot also had just discovered Gene Autry and signed him to a contract as a singing cowboy star.
Larry Darmour's Majestic Pictures had developed a following, with big-name stars and rented sets giving his humble productions a polished look.
Republic took its original "Liberty Bell" logo from M. H. Hoffman's Liberty Pictures (not to be confused with Frank Capra's short-lived Liberty Films that produced his It's a Wonderful Life, ironically now owned by Republic).
Chesterfield Pictures and Invincible Pictures, two sister companies under the same ownership, were skilled in producing low-budget melodramas and mysteries.
Thus, as Wikipedia goes on to note, acquiring and integrating these six companies allowed Republic to begin life with an experienced production staff, a company of veteran B-film supporting players and at least one very promising star, a complete distribution system and a functioning and modern studio. In exchange for merging, the principals were promised independence in their productions under the Republic aegis, and higher budgets with which to improve the quality of the films.
Okay, I think we'll stop there for today, and next week we'll look at some of the movies that Republic put out, and the circumstances that led to its eventual downfall. For now, though, let's move on with the next chapter of Dick Tracy vs Crime Inc.
Next time: Chapter 7: Sea Racketeers, and more movie serial history.
Saturday Breakfast Serial 015 – Dick Tracy vs Crime Inc. (1941) Chapter 3: Doom Patrol
February 7, 2015 February 6, 2015 ~ Michael Laws ~ Leave a comment
Welcome back! It's Saturday morning again which means it's Saturday Breakfast Serial Time! This week, it's Chapter Three of Dick Tracy vs Crime Inc. (You can find Chapter One here and Chapter Two here.)
Last week, we looked at King of the Kongo, the first partially talking serial, which was produced by Mascot Pictures. Today I thought we'd begin a look at some of the different studios that produced serials during the so-called Golden Age with a look at Mascot itself.
Mascot was formed in 1927 by producer Nat Levine, who had already independently produced his own serial, The Silent Flyer, in 1926. At first the studio simply rented its working space and equipment, but by 1933 its serials had become so popular and profitable that they were able to rent, and subsequently purchase Sennet Studios after its founder, Mack Sennet went bankrupt.
Unfortunately, by 1935, Mascot (along with a number of other studios) was so in debt to their film developer, Consolidated Film Industries, that they were forced by that company's owner, Herbert Yates, to consolidate with CFI, Monogram Pictures, Liberty Pictures, Chesterfield Pictures and Invincible Pictures to form Republic Pictures. At that point, Mascot was reduced to being the serial and B-Western arm of the company.
Mascot was responsible for discovering a number of actors who went on to have extensive careers in film, including Smiley Burnett, Gene Autry, and John Wayne. The company was also responsible for popularizing the concept of the "singing cowboy", which, while virtually unknown (except probably to film aficionados) today was once a very popular genre. They produced a number of quite well known and extremely popular serials, including The Shadow of the Eagle, The Hurricane Express, The Three Musketeers, The Lost Jungle, The Phantom Empire, The Adventures of Rex and Rinty, and The Fighting Marines.
Okay, let's move on with the next chapter of Dick Tracy vs Crime Inc.
Next time: Chapter 4: Dead Man's Trap, and more serial history.
Saturday Breakfast Serial 013 – Dick Tracy vs Crime Inc. (1941) Chapter 1: The Invisible Trail (durnmoosemovies.wordpress.com)
Saturday Breakfast Serial 014 – Dick Tracy vs Crime Inc. (1941) Chapter 2: The Prisoner Vanishes
January 31, 2015 ~ Michael Laws ~ 1 Comment
Welcome back! It's Saturday morning again which means it's Saturday Breakfast Serial Time! This week, it's Chapter Two of Dick Tracy vs Crime Inc. (You can find Chapter One here.)
A couple of weeks ago, I wrote about the transition of serials from silent to sound, a transition which would begin to give the serials more of the look and feel of the ones that are more familiar to us today. In that post, I wrote about Tarzan the Mighty, one of the first serials to include partial sound, including the first recorded "Tarzan yell". That was not however, actually the first serial to include partial sound, as that distinction actually goes to King of the Kongo which was produced by Mascot pictures in 1929 and released a few months prior to TtM.
Though the serial itself is not really considered all that interesting, it's history (and its place in history) certainly makes it so. One of the first things you need to know about sound recording for film at the time is that as opposed to the sound actually being a part of the film itself, the sound accompaniment was actually recorded onto disks that were sent along with the film and had to be synced up and played alongside the film itself. This meant that in order for there to be sound with the movie, one not only had to have a copy of the film, but the disks also, and that is where the problem with King of the Kongo and a restoration of the entire film begins, because although a complete copy of the film itself is still known to exist, most of the accompanying disks have been lost or destroyed, meaning that we will probably never have a full restoration of this important piece of cinema history.
Of course, I have to use the word "probably" there, as one never knows what might be found in the future. As a matter of fact, it's in a lot of ways a tribute to coincidence that we have as much of a restoration of the serial with its sound today as we do. I'm not going to go into the entire story of the restoration and preservation of what does exist here, but for those truly interested, at least part of the story (and some very interesting insight into the world of film collecting and preservation) can be found here.
Here's a list, thanks to Wikipedia, of what sound for this serial is known to survive, and its preservation status as of June of last year:
Chapter 1 (three reels) • Into the Unknown (no sound known to exist)
Chapter 2 (two reels) • Terrors of the Jungle (no sound)
Chapter 3 (two reels) • Temple of Beasts (no sound)
Chapter 4 (two reels) • Gorilla Warfare (sound disc for reel 2 survives)
Chapter 5 (two reels) • Danger in the Dark (full sound survives, restoration finished 2013)
Chapter 6 (two reels) • The Fight at Lions Pit (both discs survive) National Film Preservation Foundation project begins Fall 2014
Chapter 7 (two reels) • The Fatal Moment (sound disc for reel 2 survives)
Chapter 8 (two reels) • Sentenced to Death (sound disc for reel 2 survives)
Chapter 9 (two reels) • Desperate Choices (sound disc for reel 1 survives)
Chapter 10 (two reels) • Jungle Justice (National Film Preservation Foundation restoration project going on as of 6/14)
Here's a short clip from chapter 5 of the serial with the sound restored:
One other thing that should be noted about King of the Kongo is that one of its stars, unlike many silent movie actors, went on to have a very successful career in talking pictures as well. That actor? None other than horror film legend Boris Karloff!
Okay, time to move on with our own ongoing serial, Dick Tracy vs Crime Inc. After last week's rather explosive ending, it'll be interesting to see where our heroes have wound up!
Next time: Chapter 3: Doom Patrol, and a look at the studio that produced King of the Kongo, Mascot Pictures.
Indianapolis film historian says mission is to give viewers an "old-time movie experience" (fox59.com)


text:
Unit at Reflections at Keppel Bay on the market for $2.15 mil
By Charlene Chin / EdgeProp Singapore | February 3, 2022 3:09 PM SGT
SINGAPORE (EDGEPROP) - A two-bedroom unit at Reflections at Keppel Bay, located along Keppel Bay View in District 4, is up for sale under private treaty at $2.15 million ($1,678 psf), according to Edmund Tie, which has been appointed marketing agent by the bank handling the mortgagee sale.
The ground-floor unit, which spans 1,281 sq ft, offers a "good-sized" patio. It is suitable for families with kids or pets as the space can be utilised as a play area, says Joy Tan, senior director, head of auction and sales at Edmund Tie. However, the new owner will need to renovate the unit, she adds.
Tan notes that the living area is spacious and opens out to the patio. There is also an open concept kitchen, which can be enclosed with glass partitions.
The living area opens out to the patio (Credit: Edmund Tie)
Units of the same size at the development have fetched rents of $4,300 to $6,200 from October to December 2021, based on URA caveats lodged. However, as Reflections at Keppel Bay is a mega development with 1,129 units, "rents for similar sized units may range due to the unit's facing. For example, a same-sized unit on a top floor offering unblocked sea view might command a higher rate", says Tan.
"The development is part of the announced plans of the Greater Southern Waterfront City, and will probably see capital appreciation in the future as the government injects more live-work-play facilities and amenities into the area," she adds.
The government had previously announced its plans for the Greater Southern Waterfront, with the area stretching from Pasir Panjang to Marina East to be transformed into a new major gateway in the city-state.
The master bedroom comes with an en suite bathroom (Credit: Edmund Tie)
Tan believes the unit will be attractive to both investors and owner-occupiers, who could be a young couple or single working professional.
Tan says the unit is located among low-rise villa blocks which are "well-liked by many expats". She adds: "The development is also a popular condo among expats as a rental option due to its strategic location, being minutes away from the CBD, VivoCity, HarbourFront Centre, the Sentosa enclave and Mapletree Business City, which is located on Pasir Panjang Road. (Discover insightful data of any Singapore condominium with our condo directory)
The most recent transaction at the development was on Dec 30 last year, when a 1,152 sq ft unit on the eighth floor changed hands for $2.06 million ($1,789 psf). Earlier that month, on Dec 7, a 2,626 sq ft unit on the 11th floor was sold at $4.14 million ($1,576 psf), based on URA caveats lodged.
The development is a seven-minute walk to Telok Blangah MRT Station along the Circle Line. Recreational facilities and walking trails near the development include Keppel Club, Mount Faber and Labrador Nature Reserve.
Check out the latest listings near Reflections at Keppel Bay, Keppel Bay, Pasir Panjang Road, Telok Blangah MRT Station
https://www.edgeprop.sg/property-news/unit-reflections-keppel-bay-market-215-mil
Regency Park penthouse tops 2022 transactions with $8.6 mil profit
Four-bedder at Nassim 9 sold for $4.4 mil profit
ANALYSIS: Top five most unprofitable condominiums
Unit at St Regis Residences gains $1.69 mil profit


text:
Q: How can I register all my services with castle windsor wcf facility Basicly I can register one service like this.
Container.Register(Component.For<IMyService>()
                       .AsWcfClient(new DefaultClientModel() {
                            Endpoint = WcfEndpoint
                                   .BoundTo(new NetNamedPipeBinding())
                                   .At("net.pipe://localhost/MyService") })
                       .LifeStyle.PerWebRequest);

But I could not figure out how to register all my services with similar configuration.
the thing I was hoping to run is this...
Container.Register(
    AllTypes.FromAssemblyNamed("My.Server.MyContracts")
        .Pick().If(x => x.Name.EndsWith("Service"))
        .Configure(configurer => configurer.Named(configurer.Implementation.Name)
                .AsWcfClient(new DefaultClientModel
                {
                    Endpoint = WcfEndpoint.BoundTo(new NetNamedPipeBinding())
                    .At(string.Format("net.pipe://localhost/{0}", configurer.Named(configurer.Implementation.Name)).Substring(1))
                }))
            .LifestylePerWebRequest()
        );

How can I register all services as wcf client?

A: Using Windsor 3.0, you just need to use Types instead of AllTypes so that it registers the service interface and generates a client side dynamic proxy for you like so:
Container
    .Register(
        Types
            .FromAssemblyNamed("My.Server.MyContracts")
            .Pick()
            .If(x => x.Name.EndsWith("Service"))
            .Configure(
                configurer => configurer.Named(configurer.Implementation.Name)
                                  .AsWcfClient(new DefaultClientModel
                                                   {
                                                       Endpoint = WcfEndpoint
                                                           .BoundTo(new NetNamedPipeBinding())
                                                           .At(string.Format(
                                                                       "net.pipe://localhost/{0}",
                                                                       configurer.Name.Substring(1)))
                                                   }))
            .LifestylePerWebRequest());

redpajama_set_name: RedPajamaStackExchange


The Austin Police Department began rolling out more than 900 new ballistic vests last Monday in an effort to enhance safety measures for its front-line officers.
Interim Chief Brian Manley said at an APD press conference last week the department spent more than $300,000 from its general fund at the end of last year to purchase the new vests, which are capable of protecting officers from rifle fire.
Manley cited a number of statistics regarding the law enforcement community, including 135 officer fatalities in 2016. Of these fatalities, 64 were killed by firearms — a 56 percent increase from the previous year.
Law enforcement units across the nation saw a 10 percent increase in officer fatalities. Twenty-one officer deaths, the highest number in two decades, resulted from ambush-style attacks, Manley said.
Texas led the country with 17 officer fatalities last year. Manley said these statistics are proof of the significant need for APD to purchase the vests for its officers.
Of APD's approximately 1,800 officers, 958 will be receiving new vests. Manley said the vests, which each cost $336, are intended for tactical-style use, to be worn only when officers are dispatched to a call where they feel they are at a higher risk for coming across a violent encounter.
The Austin Police Association has been pushing for new protective gear since last summer after the attack on police officers in Dallas at the end of a Black Lives Matter protest.
Amplifying the safety of law enforcement officials has made it to the forefront of political conversations across the state. This legislative session, Lt. Gov. Dan Patrick has made it a priority to pass a bill creating a grant program to fund protective gear for officers across Texas.


One of the main problems to be solved in modern high energy physics experiments on particle collisions with a fixed target is the visual representation of the events during the experiment run. The article briefly describes the structure of the BM@N facility at the Nuclotron being under construction at the Joint Institute for Nuclear Research with the aim to study properties of the baryonic matter in collisions of ions with fixed target at energies up to 4 GeV/nucleon (for Au79+). Aspects concerning the visualization of data and detector details at the modern experiments and possibilities of practical applications are discussed. We present event display system intended to visualize the detector geometries and events of particle collisions with the fixed target, its options and features as well as integration with BMNRoot software. The examples of graphical representation of simulated and reconstructed points and particle tracks with BM@N geometry are given for central collisions of Au79+ ions with gold target and deuterons with carbon target.


Forward Motion. From Bach to Bebop: A Corrective Approach to Jazz Phrasing. by Hal Galper. A revolutionary breakthrough in jazz education! The core of the. 12 Jan In this book, master pianist Hal Galper also shows how get that feeling of forward motion and also how to use melody guide tones correctly. 14 Sep From Bach To Bebop A corrective approach to Jazz phrasing. I'm just getting into it on page 34 right now. This is already influencing how I.
Arpeggios and Forward Motion elaborates on how to add pickups and resolutions to arpeggios giving them a feeling of motion demonstrating the difference between themes that are in and out of Forward Motion. The great jazz drummer, Billy Hart, once confided to me that he "hears" his whole chorus in approach to "one" of the next chorus.
A good line often spells out or leads the listeners ear into the next chord early He really is just not swinging at all on any of 'em. This ability can be developed to a highly sophisticated degree. He super imposes an Ab triad on the G7b9 chord.
Superimposition is an advanced technique describing how musical freedom from the predictable elements of music: Intervals and Forward Motio n adds pickups and resolutions to large intervals broken arpeggios to give them a feeling of motion including examples of their use by modern composers and how they might be used in a solo context. Analysis of Inner Target Note Melody. Sep 16, Here's a little tidbit from the book. Sep 15, 5. It describes the functions of Tension and Release patterns rhythmically and melodically and how they can be played to create strong melodies that "spell" the changes out.
Provides more bang when the big One does arrive. Resolving Arpeggios and Creating Pickups. RichardBSep 17, We see "one" of the bar before we see any other beat or note. Therefore, effective musical statements tend to resolve at the 1 – 1 is the END of phrase. Here's a link to an old thread about the book: To support this, he shows examples of a Bach piece and cites the work of some scholar that studied Bach. Do you already have an account? It illustrates how current transcriptional analysis leads to misconceptions about how a soloist has spelled out the chord changes.
Not trying to sound mystikal or smart-assed here – but if portions of your lines are spelling triads and other such orderly constructs, the sheer strength of these structures provide the weight and melody needed for the ear to "buy" into it. Search Media New Media. Yes every note is a chord tone of some chord but the point is that it is where the line resolves to is what your ear will lock unto into. Per Galper's conception, the great musicians actually play straight 16ths so that we hear them grouped like this: However, the player is hearing thier melodic lines differently than the listener, as melodies and rhythms in motion toward future resolution points.
This contrasts with how we are taught in school, where 1 represents the beginning. LucidologySep 16, I see an area of foeward already The chapter illustrates the almost infinite ways that chord tones can be synchronized with the strong beats of the bar to clearly "spell" out chord changes.
Such is the case, for example, when looking at a modern abstract painting by Klee. Sep 14, 1. Share This Page Galpee. On page of the same volume referring to Rudolf Westphal's metrical study of the fugues in Bach's Well-tempered Clavichord "…he proves again and again that those who regard the bar-lines in Bach's music as the borders of the rhythmic factors are bound to play him unrhythmically.
Cb is the 3rd and Eb can be seen as the Altered 5th although i guess he just decided to alter it correct?
I confess that I didn't work through the examples in the book. There is also a site you can visit to hear the examples if your piano chops aren't where you'd like them to be.
Correcting Outmoded Practice Habits. In this book, master pianist Hal Galper also shows how My library Help Advanced Book Search. Sep 15, 6. Understanding Forward Motion motlon more upbeats you have in the music the more it swings" Dizzy Gillespie. You can find the link in the book itself.
It would then seem logical that melodic phrases begin on the first beat of the bar, or "one. Sep 16, 9.
Galper contends that we must learn to hear 1 as the resolution of the prior measure. In the key of Bb The moton goes like this: When faced with a problem or something that doesn't make sense, it galpee tries to make sense out of it by relating it to the familiar. Rhythmic Forward Motion introduces the basic concept of Forward Motion, starting with how my study of it began and how music is almost universally taught "backwards" from the way it really functions.


text:
Contemporary Pop/Rock, Teen Pop, Alternative/Indie Rock, Punk-Pop
Band Members: Jess Origliasso, Lisa Origliasso, Vik Foxx
The album Revenge Is Sweeter Tour was released. Release Date: September 04, 2009
"The Veronicas hail from Brisbane, Australia, where twin sisters Jess and Lisa Origliasso began working in show business at the age of five. Born on Christmas Day in 1984, Jess a..." Read more
Preview songs from The Veronicas
Take Me on the Floor
Everything I'm Not
Hook Me Up
The Secret Life Of...
Label: Sire/Warner Reprise Video
"The Veronicas sound like a marketer's dream: impossibly cute Australian twin sisters who sound as if Hilary Duff and Avril Lavigne formed a band. If image is everything, this duo has a look th..." Read more
When It All Falls ...
Mouth Shut
Heavily Broken
I Could Get Used t...
Hook Me Up [Bonus Track]
Label: Sire
"Based on the vampy, electro-pop title track and its accompanying video -- which features the Origliasso twins dressed in school uniforms (a teen pop tradition dating back at least to Britney Spears..." Read more
This Is How It Feels
I Can't Stay Away
I Don't Wanna Wait
Revenge Is Sweeter...
Someone Wake Me Up
All I Have
In Another Life
The Pretty Rec...
Emii
Nikki Clan
Everlife
Tiffany Page
The Love Willows
Meg & Dia
The Faders
Amy Diamond
Amy Pearson
Sandy & Júnior
Emelee


"I first purchased my '55 Chevy truck on a live auction from eBay. The truck was purchased from a person in Illinois, sight unseen, who said it was in mint condition. When the carrier went to pick the truck up, the owner called and told me they scratched the driver door. When the truck arrived at my doorstep I asked to see the scratch, and it wasn't that bad. I then began to look at the rest of the truck. It was battleship gray and the paint had runs and sanding marks all through it. The clearcoat on the truck looked as if raindrops had landed before it set up. My wife and I looked at each other and thought: Mint condition? Even the carrier said I hope you didn't pay much for it. Needless to say the minor scratch the carrier put in it was the least of my worries. My grandfather owned two '55 Chevy trucks for his gas station way back when, and I always wanted to build one of these trucks, so I was determined to restore my "mint" '55.
It doesn't take but one look at Ed Fiveash's, of Sharpsburg, Georiga, '72 Chevy to realize he lives and breathes Smokey Yunick. Like so many others, Ed is just another in a long line of Smokey fans, and the best way he knew to pay tribute to the innovator himself was to build his Chevy in memory of Smokey. The truck is centered on its T&L Engine Development-built440-horsepower 383 Chevy that is equipped with Dart Pro II heads, Edelbrock intake, custom ground cam, and more. Ed then shaved the truck clean, and lowered it on the ground. He also built a custom stainless steel exhaust system, gas tank, and more. Lastly, Ed, once again, laid down the trademark Smokey two-tone paintjob. Ed also made it a point to us in his letter that he is the original owner of the truck and it has never been wrecked. As for Ed though, that's a whole-nother' story.


text:
Scilla Alecci
The response some reporters got in Europe.
Looking for answers in blacked-out documents and hidden records
"The patient XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXX …
XXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXXThe lead was discarded after explant, so was unable to be analyzed by the manufacturer."
A glitch in this article? No. An example of what the International Consortium of Investigative Journalists and its partners in the Implant Files investigation received when they asked for public information on faulty medical devices.
A section of a Dutch response.
This one from the Netherlands was typical in its redaction (or blacking out) of information that might have been more specific and revealing.
More than 250 reporters from 36 countries participated in the global investigation led and reported on by ICIJ. Over the course of the nearly year-long probe, they filed more than 1,500 requests for public records in their countries. But not even half were successful. In one that was strikingly not, Mexican reporters submitted 964 requests to federal agencies that produced only 44 responses.
Across the world, public bodies in charge of monitoring and regulating the medical device industry, as well as of keeping track of incidents caused by the devices, have fully or partly denied journalists' requests for public records for a variety of reasons.
Among the rationales for rejecting requests or redacting documents: classified information or absence of data in Mexico and France; a year-long backlog of requests in the U.S.; lack of staff who can redact sensitive details in Belgium; trade secrets in Japan, Europe, the U.K. and many other countries.
Disclosure and public scrutiny are very important in finding what is wrong in our community
Yasuomi Sawa
When reporters did get data on incident reports, it wasn't always in a format that could be used to do trend analysis or advance any reporting leads.
In France, the list of incidents associated with medical devices that was provided by health authorities looked like "a spreadsheet filled by an intern," said Le Monde's Stéphane Horel. The file didn't include any information on incident outcomes, such as deaths or injuries, and had many empty rows, she said. "That's how we realized the system is broken."
If authorities can't keep track of possibly harmful incidents, who can?
Everything You Need to Know About the Implant Files
Our year-long investigation uncovered the harm caused by poorly-tested medical devices. Here's what we found.
Medical Devices Harm Patients Worldwide As Governments Fail On Safety
Medtech Giant Pushes Boundaries As Casualties Mount And Sales Soar
In Canada, it took two years for David McKie, a data journalist with Canadian Broadcasting Corporation, to obtain adverse event data from the national regulatory agency.
The breakthrough came last summer when a frustrated McKie decided to apply a strategy basketball players use when a victory is uncertain. "I exercised a 'full-court press' where you pull out all the stops in order to achieve success," McKie said. "I complained and inundated [the agency] with requests. I became one of their bigger problems."
Just a few months before publication, his efforts were successful. CBC obtained a copy of Canada's medical device adverse event data since 1977, which went on to become the "heart" of the reporting team's investigation.
"The database gave us an unprecedented window into the medical device regulatory process," McKie said. It also "highlights that lack of transparency is at the heart of the system."
CBC created Canada's first medical device incident database and made it available for the public on its website. ICIJ created another database, also from public records. The International Medical Devices Database permits users to explore more than 70,000 recalls, safety alerts and field safety notices in 11 countries. Users can search by device name, by manufacturer, or by country, and the database will grow as ICIJ acquires and records more information.
More than one hundred countries around the world have legislation on freedom of information, but its application "leaves a lot to be desired," said Toby Mendel, director of Halifax-based Centre for Law and Democracy and specialized in freedom of expression law.
Some reporters also fear that corporations' concerns tend to prevail even when public health is at stake.
Jet Schouten, a reporter with Dutch TV show Radar, who has been covering safety issues tied to medical devices for years, said she was "flabbergasted" when her country's authorities explained the reason they weren't publishing all the adverse event reports they receive.
Their response to Schouten and the daily Trouw put it simply: "The relationship between the inspectorate and manufacturers of medical devices, which is indispensable for the effective monitoring of the profession, will be disproportionately damaged by the disclosure of medical data."
The response from authorities in The Netherlands.
"It's a system based on fear," Schouten said. Regulators "listen to the industry and not to patient safety."
A week after publication, in countries such as France, Spain and Japan, ICIJ's media partners' fight — and long wait — for open records continues.
"Disclosure and public scrutiny are very important in finding what is wrong in our community," said Yasuomi Sawa, a reporter with Japanese news agency Kyodo, who is still waiting for a response to his team's 76 requests. Just because the government has information on medical device safety it doesn't mean the public is safe, he said.
Read (some of) the FOIA responses ICIJ and partners received
Manufacturers Incident Report
FOIA Response, The Netherlands – Ministerie van Volksgezondheid Wlzijn en Sport
DM Retirados Del Mercado Por Cofepris – 2018
Cofepris Retiros Alertas FDA – 2018
Team NB- EC on Notified Bodies – 2012
EC document on Notified Bodies – 2012
EC "revision of MD legislation" – 2012
Draft report of EP on MD regulation – 2013
EC Medtech Europe – 2013
Eucomed – 24 Ares(2013)3050282
EC Mimica's Hearing in the EP – 2018
France NCARs 2012 2018
European Commission's rejection letter
Medtronic FDA Inspection Document – 2013
Baxter Auto Syringe AS50A 501(k) Review – 1994
Response – Infusion Systems LLC Request for Summary of Safety and Effectiveness – 2010
Infusion Systems LLC Request for Summary of Safety and Effectiveness – 2008
FDA Response – University of Washington request for Medtronic SynchroMed research and studies – 2008
University of Washington FDA request for Medtronic SynchroMed research and studies – 2005
Medtronic SynchroMed Recall Action Memo
Covidien pension complaint
Codman Infusion Pump FDA Summary of Safety and Effectiveness – 1991
Medtronic SynchroMed Summary of Safety and Effectiveness – 1988
Medtronic SynchroMed Intraspinal Morphine Supplement – 1991
Medtronic Parmadigm Complaint – 2016
Dexcom Consumer Fraud Complaint – 2008
Recall recommendation review SynchroMed – 2018
CDRH's Health Hazard Evaluation SynchroMed II – 2011SynchroMed II – 2011


text:
Die Posteriore amorphe Hornhautdystrophie (PACD) ist eine sehr seltene angeborene Form einer Hornhautdystrophie mit unregelmäßigen, formlosen (amorph), blattartigen Trübungen im hinteren Teil des Stromas und in der Descement-Membran und nur geringer Beeinträchtigung der Sehschärfe.

Synonym: Posteriore amorphe Stromadystrophie; Chromosom 12q21.33 Deletionssyndrom

Die Bezeichnung bezieht sich auf die Erstautoren der Erstbeschreibung aus dem Jahre 1977 durch den US-amerikanischen Emmett F. Carpel und Mitarbeiter.

Verbreitung
Die Häufigkeit wird mit unter 1 zu 1.000.000 angegeben, die Vererbung erfolgt autosomal-dominant.

Ursache
Der Erkrankung liegen Mutationen auf dem Chromosom 12 Genort q21.33 zugrunde.

Klinische Erscheinungen
Klinische Kriterien sind:
 Krankheitsbeginn meist innerhalb der ersten 10 Lebensjahre
 nicht oder nur langsam fortschreitende diffus grau-weißliche, blattartige Hornhauttrübung, insbesondere im hinteren Stromaanteil
 nur gering eingeschränkte Sehschärfe
Hinzu können Veränderungen an anderen Augenabschnitten kommen wie irido-korneale Adhäsionen, Korektopie und Pseudo-Polykorie.

Differentialdiagnose
Abzugrenzen sind andere Formen der Hornhautdystrophie.

Literatur
 M. J. Kim, R. F. Frausto, G. O. Rosenwasser, T. Bui, D. J. Le, E. M. Stone, A. J. Aldave: Posterior amorphous corneal dystrophy is associated with a deletion of small leucine-rich proteoglycans on chromosome 12. In: PLOS ONE. Bd. 9, Nr. 4, 2014, S. e95037, doi:10.1371/journal.pone.0095037, PMID 24759697, .
 L. A. Oliveira, L. A. Vieira, D. d. Freitas, L. B. Sousa: Distrofia corneana amorfa posterior: relato de caso. In: Arquivos brasileiros de oftalmologia. Bd. 69, Nr. 6, 2006 Nov-Dec, S. 945–947, PMID 17273695.

Einzelnachweise

Seltene Krankheit
Erbkrankheit
Krankheitsbild in der Kinderheilkunde
Krankheitsbild in der Augenheilkunde


Hi all! Happy to share this fun little pocket scrapbooking page with you! I adore this fun little Feel it All mini kit that Tina Azsmus designed. I love the stamps that she came up with and the fun paper sizes are all really pretty too! Because it's December Daily time, I couldn't think of making another little notebook right now but I love that I still have lots left of this kit if I wanted to in the new year. So I went ahead and made a page with my Project Life album.
I used the page with 2x2 pockets and cut out my favorite images. For the pages that had bigger words than the 2x2 pocket size, I just trimmed them to fit next to each other on 2 squares. My favorite stamp is the mood one! I love the outline separate on that.
For the photo of this layout, I chose one of myself in Malibu. It's a pretty important photo to me, not only because I am sure this area was in the fires that took over Malibu recently- and it breaks my heart. So I will treasure this special trip that my husband and I took while we stayed at this most amazing Airbnb Airstream. Also it's super rare of me to have a photo by myself. And it just emulates the whole 'mood' theme, I think!! I love it.
Because this is a 5x7 photo, I didn't have a sleeve to fit it perfectly. I'm going to punch some holes so that it fits like this in this photo. I didn't have the heart to do it right this second but I will for sure be doing it so I can store it properly in my book!
Thanks for stopping by the blog! I hope that you had a chance to snag this awesome set!


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Join Kings of Leon, Mayor Holt & City Council to dedicate Kings of Leon Lane in Bricktown, Sept. 27
Link to story
Join Kings of Leon, Mayor David Holt and the Oklahoma City Council to officially dedicate the newly named Kings of Leon Lane in Bricktown.
"We are thrilled to recognize Kings of Leon for their Oklahoma City roots and their support of our city through the years," said Mayor Holt. "Kings of Leon now joins a constellation of OKC musical stars celebrated in Bricktown, including Charlie Christian, Wanda Jackson, Vince Gill and The Flaming Lips. These namings are our opportunity to remind the world the artistic brilliance that originates in OKC, and remind our young people that they can be anything they want to be."
The dedication is 2 p.m. Friday, Sept. 27, at the corner of California and Joe Carter avenues.
The City Council voted in August to re-name E California Avenue to honor the band, which has Oklahoma City ties. Kings of Leon Lane is the new name of the street for the stretch between Joe Carter and Charlie Christian avenues.
Kings of Leon is a Grammy Award-winning rock band formed in 1999 with four members of the Followill family. Some of the band members lived in Oklahoma City as kids.
Kings of Leon is headlining a free concert later Friday to celebrate the grand opening of MAPS 3's Scissortail Park. The show is on the Love's Travel Stops Stage and Great Lawn in the middle of the park. Visit scissortailpark.org for more information about the show and other events on its opening weekend.
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