text:
The efficacy and safety of thrombolytic agents for patients with prosthetic valve thrombosis
Vinod Sharma1, Brig Y K. Arora1, Lokesh Chandra Gupta1, Amitabh Poonia1, Sukriti Raina1, Uday Singh Yadav1, Ruchi Sharma2, S Dwivedi1
1 Department of Cardiology, National Heart Institute, New Delhi, India
2 Department of Cardiology, Hamdard Institute of Medical Sciences and Research, New Delhi, India
Date of Acceptance 06-Apr-2022
Vinod Sharma
National Heart Institute, New Delhi
DOI: 10.4103/jpcs.jpcs_54_21
Introduction: Prosthetic valve thrombosis (PVT) is a serious complication seen with mechanical prosthetic cardiac valves and is associated with high mortality. Emergency surgery (thrombectomy or valve replacement) had been the traditional treatment, but now with intravenous thrombolytic therapy as an alternative to emergency surgery in patients with PVT has shown excellent success rate and acceptable risk. This study is aimed to determine efficacy and safety of use of thrombolytic agents (tPA or STK) in patients with PVT. Materials and Methods: This was a retrospective, single-center study of patients with PVT admitted between 2004 and 2020 at a tertiary care center in North India. The diagnosis of PVT was based on a history of prosthetic heart valve replacement, clinical presentation, and by diagnostic methods. All patients received either tenecteplase or streptokinase given as a bolus dose of 2.5 lac units over ½ h, followed by 1 lac units/h for 24–48 h depending on clinical response and complication, whereas tenecteplase (1 mg/kg of body weight) was given as bolus. Results: Of 72 patients, 45 patients received t-PA as a thrombolytic drug. Complete success was obtained in 39 patients (86.66%), whereas partial success in 3 (17.77%) and failure in 3 (6.66%). Among the patients who received streptokinase (n = 27), complete success was found in 23 patients (85.19%), whereas partial success was seen in 3 (11.11%) and failure was seen in 1 patient (3.7%). Conclusion: Thrombolysis is a reasonable option in patients with PVT. Our study has reiterated that major factors for PVT are warfarin poor compliance and subtherapeutic international normalized ratio. Postclosure clinical follow-up along with patient education should be followed in patients with mechanical prosthetic valve.
Keywords: Prosthetic valve thrombosis, streptokinase, thrombolysis
Sharma V, K. Arora BY, Gupta LC, Poonia A, Raina S, Yadav US, Sharma R, Dwivedi S. The efficacy and safety of thrombolytic agents for patients with prosthetic valve thrombosis. J Pract Cardiovasc Sci 2022;8:30-4
Sharma V, K. Arora BY, Gupta LC, Poonia A, Raina S, Yadav US, Sharma R, Dwivedi S. The efficacy and safety of thrombolytic agents for patients with prosthetic valve thrombosis. J Pract Cardiovasc Sci [serial online] 2022 [cited 2023 Jan 31];8:30-4. Available from: https://www.j-pcs.org/text.asp?2022/8/1/30/344132
Prosthetic valve thrombosis (PVT) is a serious complication seen with mechanical prosthetic cardiac valves and is associated with high mortality. PVT incidence was reported to be 0.03% in bioprosthetic valve and 0.5%–8% in mechanical valves in mitral and aortic positions.[1] Emergency surgery (thrombectomy or valve replacement) had been traditional treatment, but now with intravenous thrombolytic therapy as an alternative to emergency surgery in patients with PVT has shown excellent success rate and acceptable risk.[2] Ours is a single-center retrospective study aimed to determine the efficacy and safety of use of thrombolytic agents (tPA or STK) in patients with PVT.
Patients selection
This was a retrospective, single-center study of patients with PVT admitted between 2004 and 2020 at a tertiary care center in North India. The study was approved by the Institutional Ethics Committee, All India Heart Foundation, New Delhi, on September 8, 2021 (Ref. No. F.No. 3/9/2021). Informed consent was waived due to the study being retrospective in nature. The clinical profiles, including their demographic characteristics, clinical symptoms on presentations, time of presentation to hospital after onset of symptom, and the interval between valve replacement and onset of symptoms suggestive of PVT, were analyzed. The diagnosis of PVT was based on the history of prosthetic heart valve replacement, clinical presentation, and by diagnostic methods including transthoracic echocardiography (TTE), transesophageal echocardiography (TEE), and fluoroscopy. PVT was considered obstructive if TTE showed a high pressure gradient across prosthetic valve along with reduced or fixed leaflet mobility on fluoroscopy. Patients with infective endocarditis or those with patient's prosthesis mismatch (characterized by high gradient on TTE but normal leaflet motion on fluoroscopy) were excluded from the study. All patients received either tenecteplase or streptokinase given as a bolus dose of 2.5 lac units over ½ h, followed by 1 lac units/h for 24–48 h depending on clinical response and complication, whereas tenecteplase (1 mg/kg of body weight) was given as a bolus. TTE and fluoroscopy were repeated after completion of thrombolysis in all patients [Table 1].
Table 1: Diagnostic modalities subjected to patients
Analyzing outcomes
Postthrombolysis valve function was considered to be normally restored if the TTE revealed 50% or equal or more than 50% reduction in transvalvular gradient as compared to baseline with restoration of normal leaflet motion on fluoroscopy. "Complete success" of fibrinolytic therapy was considered if there was restoration of normal valve function along with clinical improvement in the absence of death, need for surgical intervention, or any major complication including stroke or major bleeding (intracranial bleed or bleeding requiring transfusion or surgical treatment) during the hospital stay. "Partial success" was defined if the restoration of normal valve function was associated with any major complication or incomplete restoration of valve function (characterized by restricted movement of valve leaflets on fluoroscopy despite normalize transvalvular gradient) requires surgical referral. Death or absence of hemodynamic response (after 24 h of fibrinolysis) was considered as "failure of fibrinolysis," whereas near normalization of transvalvular gradient irrespective of leaflet mobility was considered as "hemodynamic success."
Statistical analysis was done using SPSS version 16.0 software (SPSS Inc., Chicago, USA), and the data were presented as mean, standard deviation, and percentages.
During the study, 72 patients were diagnosed with PVT and received thrombolytic treatment with either tenecteplase or streptokinase as first-line treatment. Out of these patients, 29 were male (40.27%) and 43 were female (59.73%) with age group between 19 and 53 years with a mean age of 39 years.
Majority of the patients presented with symptoms of breathlessness and palpitation. While 13 patients (18%) were in NYHA class II, 41 patients (56.94%) were in NYHA class III and 11 patients (15.27%) were in NYHA Class IV. Out of these 11 patients in class IV, 7 patients (9.72%) had hemodynamic instability in the form of blood pressure less than 90 mm of Hg. Majority of the patients (n = 59; 55%) had an international normalized ratio (INR) in nontherapeutic range (<2). Acenocoumarol was the most commonly prescribed anticoagulant (58%), followed by warfarin (42%). Twenty-eight patients (38.80%) received aspirin + coumarin. 79% of patients were poorly complaint with the use of oral anticoagulant drug and monitoring of prothrombin time [Table 2].
Table 2: Clinical characteristics (demographics and other patient related variables)
Of all the valves implanted, almost all were bileaflet tilting disk type (St Jude, Medtronic Hall valve). The average interval following their prosthetic heart valve thrombosis varied from 2 to 5 years with an average of 3.1 years. Seventy-one (98.3%) patients presented with first-time thrombosis after prosthetic valve replacement, whereas 1 had prior history of PVT [Table 3].
Table 3: Time of presentation after valve replacement
The valves affected were mitral valve in 56 patients (77.77%) and aortic valve in 7 patients (9.72%) and mitral and aortic in 9 patients (12.5%) each [Table 4]. Of 72 patients, 56 patients (77.78%) were in atrial fibrillation and 16 were in sinus rhythm (22.22%). The left ventricular ejection fraction was normal (more than 50%) in 53 patients (73.60%) and impaired (<35%) in 19 patients (26.4%). Fluoroscopic findings showed that 58 patients presented with hypomobile leaflets, 12 presented with one completely struck leaflet, and one patient presented with both completely struck leaflet [Table 5]. The mean transvalvular gradient across the thrombosed mitral valve varied from 18 to 28 mm with an average of 24 mm, whereas in aortic prosthesis, the gradient varied from 32 to 58 with an average of 46 mm. Floating thrombus in atria was found in 3 patients on TEE.
Table 4: Patient's characteristics related to valve
Table 5: Fluoroscopic findings
The thrombolytic drug was streptokinase in 27 patients and t-PA in 45 patients as per the dose. All patients received either tenecteplase or streptokinase given as a bolus dose of 2.5 lac units over ½ h, followed by 1 lac units/h for 24–48 h depending on clinical response and complication, whereas tenecteplase (1 mg/kg of body weight) was given as a bolus [Table 6]. The complete success was seen in 39 out of 45 patients (86.66%) in t-PA group, whereas 3 patients out of 45 (6.8%) had partial success. Three patients out of 45 (6.88%) did not have significant fall in gradient nor improvement in the mobility of prosthetic heart valve disk. Of the 27 patients who received streptokinase, 27 (85.18%) had complete success while 3 (11.11%) had partial success. Two patients from t-PA group and one patient in STK group did not have response to the thrombolysis, who were subjected to semiurgent valve replacement. Only one patient in tPA group suffered major bleed (intracranial hemorrhage), whereas minor bleed in the form of gum bleed was seen in 5 patients in tPA group and 3 patients in STK group. Patient in tPA group who suffered intracranial bleed subsequently expired. One patient from tPA group had thromboembolism to the left dorsalis pedis artery which was managed conservatively, whereas 2 patients in STK group had thromboembolism to femoral artery, both required embolectomy.
Table 6: Thrombolytic drugs used
All patients underwent fluoroscopy to ascertain the degree of opening of the valve. Of those who had successful thrombolysis, follow-up echocardiogram after 3 months revealed the adequate opening of prosthetic valve in all patients. They were put on oral anticoagulant with antiplatelet drugs with the strict monitoring of anticoagulation profile and keeping the INR in range of 2.5–3 [Table 7] and [Table 8].
Table 7: Outcomes after thrombolysis
Table 8: Comparison of transvalvular gradient before and after thrombolysis
Mechanical valve thrombosis is a serious complication of valve replacement. It is typically a subacute to acute event, resulting in rapid valve dysfunction and needing urgent diagnostic evaluation and appropriate treatment.
The annual rate of PVT with mechanical valve varies from 0.1% to 5.7%. Mechanical valves in mitral or tricuspid position are more prone to thrombosis compared with aortic position.[3]
In India, the prevalence of prosthetic heart thrombosis within 6 months of valve replacement is 6.1%.[4]
Inadequate anticoagulation, atrial fibrillation, left ventricular dysfunction-associated hypercoagulable state such as pregnancy, and early postoperative period are common risk factors for PHT. A higher rate of mechanical valve thrombosis is seen in old design and secondary to pannus or vegetation.
It has been observed that even with proper anticoagulation, the incidence rate of valve thrombosis is 0.12%–5.7% per patient per year. Even with use of warfarin, the risk of thromboembolism is 1%–2% per year, the risk is considerably high without treatment with warfarin.[5],[6]
A variable time between valve replacement and PHT has been reported from as early as 10 days after replacement to more than 10 years. The mean time interval between valve replacement and thrombosis of 4.3 years (range, 14 days–18 years) was reported in a series of 127 cases by Roudaut et al.[7] In the present study, we found that 37 (51.38%) patients had valve replacement within 3 years, while 28 (38.88%) patients had valve replacement within 3–5 years and 7 (9.72%) had valve replacement above 5 years. Majority of valve thrombosis in our series falls into the category of very late thrombosis.[8] Subtherapeutic anticoagulation was the major (79.17%) risk factor associated with PVT, which was mainly due to a lack of regular follow-up and poor treatment compliance. Similar observations were also found in the study conducted from India, which shows variable rate of inadequate anticoagulation ranging from 41.5% to 90.3%.[9] Mitral valve prosthesis is 2–3 times more frequent than thrombosis in aortic position, which was also found in previous Indian studies.[2],[10] In our study also, 77.7% of PVT episode occurred in mitral position alone, while 12.5% occurred in both mitral and aortic position. The diagnosis of PVT requires clinical suspicion along with investigations such as TTE, TEE showing elevated transvalvular gradient along with reduced or fixed leaflets mobility on echocardiography and/or fluoroscopy. Besides the TTE, TEE is helpful in evaluating thrombus burden and differentiating thrombus from the pannus.
In majority of the patients (49/72), transthoracic echocardiography was reasonably informative in our study to suggest for PVT. However, in 23 patients with a diagnostic doubt, TEE was performed. Whenever there is diagnostic doubt about PVT on TTE and color flow mapping, TEE can be used to confirm the diagnosis and decide the treatment strategies. TEE, besides diagnosing PVT causing obstruction, also helps in assessing the thrombus size, its location, and mobility. Large thrombi can lead to thromboembolic events, heart failure, and even cardiac arrest. Thrombus size measured by transesophageal echocardiogram is crucial in determining the best treatment strategies. Higher success rate with thrombolysis has been reported in cases with prosthetic valve thrombus size <1.0 cm2.[11]
Treatment of prosthetic valve thrombosis
Currently, there is no evidence in the form of results of randomized controlled trials favoring surgery over thrombolysis for the treatment of prosthetic heart valve thrombus. The superiority of surgery or thrombolytic therapy is related to the patients' hemodynamic condition. Thrombolytic therapy for left-sided PVT is associated with bleeding, thromboembolism, and recurrent thrombosis of prosthetic valve, while surgery is associated with high mortality. The mortality of surgery in some of the series is as high as 61% according to the functional class and to the emergency of intervention in these patients.[8]
Thrombolysis has been treatment of choice for prosthetic heart valve thrombosis due to its ease of availability and comparatively low cost. The success rate of thrombolysis for prosthetic heart valve thrombosis has been from 67% to 93.3% in various series.[8] Lim et al.[10] in a systematic review of trials of thrombolytic therapy in PHT reported success rate of 58%–90%, with 30-day mortality rate ranging from 0.8% to 16.7%, thromboembolism from 1.7%–17.6%, and major bleeding ranged from 1.7% to 12%. Similarly, Lengyel and Venderin, a recollection of 10 studies (515 cases), showed a success rate of 84%, mortality of 5%, major bleed in 3%, systemic embolism in 9%, brain embolism in 1.5%, and a recurrence rate of 16%.[12] Gupta et al.[13] in a series of 110 patients reported complete hemodynamic response in 81.1% of patients, partial response in 10%, and failure in 8.2%. Embolic events were seen in 21 (19.1%) cases, out of which 6 (5.5%) had cerebral embolism. In our study, out of 72 patients, 45 patients received t-PA as a thrombolytic drug and complete success was obtained in 39 patients (86.66%), while partial success in 3 (17.77%) and failure in 3 patients (6.66%). Among the patients who received streptokinase (n = 27), complete success was found in 23 patients (85.19%), while partial success was seen in 3 (11.11%) and failure was seen in 1 patient (3.7%). Only one patient in t-PA group had major bleed and of minor bleed was seen in 3 patients of STK and 5 patients of t-PA group. Thromboembolism was seen in 1 patient in t-PA group, while among the group which received streptokinase, 2 patients had peripheral thromboembolism, which requires embolectomy. One patient in t-PA group developed intracranial hemorrhage who subsequently died. The complication rate in our series was comparable with previous studies.
Our study has re-emphasized the fact that poor compliance with warfarin and subtherapeutic INR are still a major factor in the occurrence of PVT and therefore re-emphasizes the fact that patients with mechanical prosthetic valve need a closure clinical follow-up along with patient education.
The limitation of our study is that it is a single-centered retrospective study. It has a reasonable sample size for this specific study population. However, all the patients included in this study were of mechanical valve thrombosis. The applicability of this finding to the bio-PVT may be questionable. Another limitation is being retrospective in nature, and all the patients did not have fluoroscopic and transesophageal imaging, which could help in better definition of PVT and thrombus size.
This study was done in a single center restricting to patients of North India, which was the limitation of the study.
Prosthetic heart valve thrombosis is a common occurrence, especially the left-sided prosthetic heart valve. Subtherapeutic anticoagulation and atrial fibrillation are major risk factors for developing prosthetic heart valve thrombosis, which can be prevented by a close follow-up to ensure the patient's treatment compliance. Thrombolysis is a reasonable option in patients with left-sided PVT with an excellent success rate and acceptable complication.
Ethics clearance
The study was approved by Institutional Ethics Committee, All India Heart Foundation, New Delhi.
Özkan M, Gündüz S, Biteker M, Astarcioglu MA, Çevik C, Kaynak E, et al. Comparison of different TEE-guided thrombolytic regimens for prosthetic valve thrombosis: The TROIA trial. JACC Cardiovasc Imaging 2013;6:206-16.
Cáceres-Lóriga FM, Morais H. Thrombotic obstruction in left-side prosthetic valves: Role of thrombolytic therapy. Indian Heart J 2015;67 Suppl 2:S10-2.
Dangas GD, Weitz JI, Giustino G, Makkar R, Mehran R. Prosthetic heart valve thrombosis. J Am Coll Cardiol 2016;68:2670-89.
Pradhan A, Bhandari M, Gupta V, Vishwakarma P, Sethi R, Narain VS, et al. Short-term clinical follow-up after thrombolytic therapy in patients with prosthetic valve thrombosis: A single-center experience. Cardiol Res 2019;10:345-9.
Grunkemeier GL, Li HH, Naftel DC, Starr A, Rahimtoola SH. Long-term performance of heart valve prostheses. Curr Probl Cardiol 2000;25:73-154.
Cannegieter SC, Rosendaal FR, Briët E. Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses. Circulation 1994;89:635-41.
Roudaut R, Serri K, Lafitte S. Thrombosis of prosthetic heart valves: Diagnosis and therapeutic considerations. Heart 2007;93:137-42.
Cáceres-Lóriga FM, Pérez-López H, Morlans-Hernández K, Facundo-Sánchez H, Santos-Gracia J, Valiente-Mustelier J, et al. Thrombolysis as first choice therapy in prosthetic heart valve thrombosis. A study of 68 patients. J Thromb Thrombolysis 2006;21:185-90.
Nawale JM, Chaurasia AS, Nalawade DD, Abdagire N. Clinical profile of patients with prosthetic valve thrombosis treated with fibrinolysis. J Pract Cardiovasc Sci 2018;4:109.
Lim WY, Lloyd G, Bhattacharyya S. Mechanical and surgical bioprosthetic valve thrombosis. Heart 2017;103:1934-41.
Katz M, Tarasoutchi F, Grinberg M. Thrombolytic therapy in prosthetic valve thrombosis. Arq Bras Cardiol 2005;85:76-8.
Lengyel M, Vandor L. The role of thrombolysis in the management of left-sided prosthetic valve thrombosis: A study of 85 cases diagnosed by transesophageal echocardiography. J Heart Valve Dis 2001;10:636-49.
Gupta D, Kothari SS, Bahl VK, Goswami KC, Talwar KK, Manchanda SC, et al. Thrombolytic therapy for prosthetic valve thrombosis: Short- and long-term results. Am Heart J 2000;140:906-16.
[Table 1], [Table 2], [Table 3], [Table 4], [Table 5], [Table 6], [Table 7], [Table 8]
Sharma V
K. Arora BY
Gupta LC
Poonia A
Raina S
Yadav US
Sharma R
Dwivedi S
Prosthetic valve thrombosis
streptokinase


text:
Eligibility of Capital gains deuction if Assessee failed to deposit unutilized amount of capital gains in capital gains scheme account by date of filing of return of income
Short Overvivew : Where assessee failed to deposit unutilized amount of capital gains in capital gains scheme account by the date of filing of return of income, the assessee would not be entitled to the claim of deduction under section 54F.
Assessee claimed deduction under section 54F on account of investment made in a specified bank/institution. Revenue rejected the said claim of deduction alleging that the assessee did not deposit unutilized amount of capital gains in capital gains scheme account by the due date of filing return of income.
it is held that: Since assessee failed to deposit unutilized amount of capital gains in capital gains scheme account by the date of filing of return of income, the assessee would not be entitled to the claim of deduction under section 54F.
Decision: Against the assessee.
IN THE ITAT, PUNE BENCH
SUSHMA CHOWLA, J.M. & ANIL CHATURVEDI, A.M.
Sameer Vithalrao Ghanwat v. ITO
ITA No. 645/PUN/2018
Appellant by: None
Respondent by: Rajesh Gawali
Sushma Chowla, J.M.
The appeal filed by assessee is against order of Commissioner (Appeals), Pune-5, dated 4-12-2017 relating to assessment year 2013-14 against order passed under section 143(3) of the Income Tax Act, 1961 (in short 'the Act').
2. Despite service of notice, none appeared on behalf of assessee nor any application was moved for adjournment. However, because of the issue involved, we proceed to decide the present appeal after hearing the learned Departmental Representative for the Revenue.
3. The assessee has raised the following grounds of appeal :–
On the facts and in the circumstances of the case and in law, the learned Commissioner (Appeals) has :–
1. Erred in confirming the cost of acquisition of the land sold by the Appellant as on 1-4-1981 at Rs. 10,360 as against Rs. 3,59,648 claimed by the Appellant.
2. Erred in confirming the deduction claimed under section 54F of the Act at Rs. 33,48,003 as against Rs. 45,41,736 claimed by the Appellant.
3. Erred in passing the ex parte order by not granting the Appellant sufficient opportunity of being heard.
In view of the above grounds and on the facts and in the circumstances of the case and in law, the Appellant prays Your Honour to allow the appeal and set aside the orders passed by the lower authorities, being not justified in law and pass any other order which Your Honours may deemed fit in the interest of justice.
4. The first issue raised is against cost of acquisition of the property as on 1-4-1981.
5. Briefly, in the facts of the case, the assessee had filed original return of income of income on 30-7-2013 declaring income at Rs. 2,42,617. For the year under consideration, the assessee had sold his land at Balewadi, Tal. Haveli, Pune Dist. on 27-9-2012. The assessee had shown the cost of acquisition of the said property as on 1-4-1981 at Rs. 3,59,648, whereas the assessing officer had adopted at Rs. 10,360.
6. The perusal of assessment order reflects that the assessee had admitted before the assessing officer to adopt the cost of acquisition at Rs. 10,360. In view of the admission of assessee, there is no merit in the ground of appeal raised by assessee in this regard. Hence, the same is dismissed.
7. Now, coming to the claim of deduction under section 54F of the Act at Rs. 33,48,003 as against Rs. 45,41,736.
8. Brief facts relating to the issue are that the assessee explained that he had purchased a new residential property jointly with his wife on 4-3-2013 for a total consideration of Rs. 53,85,000, out of which an amount of Rs. 33,85,130 has been claimed as deduction under section 54 of the Act by the assessee and the balance has been claimed as deduction under section 54F of the Act by his wife. Further, the assessee had also claimed deduction of Rs. 11,56,606 under section 54F of the Act on account of investment made in a specified bank/institution. Thus, the total deduction claimed under section 54F of the Act by the assessee was at Rs. 45,41,736. However, the assessing officer on verification of the details submitted during the course of assessment proceedings, noted that the entire claim made by assessee could not be allowed in view of the provisions of section 54F(1)(b) and 54F(4) of the Act and the proviso thereof. In the instant case, the net consideration of the original asset was at Rs. 80,48,041, i.e., after considering expenditure by way of cost of selling, whereas the cost of net asset was only Rs. 33,85,130 as claimed by the assessee in the computation. Thus, the proportionate amount of deduction under section 54F of the Act allowable would work out to Rs. 33,48,003 [33,85,130 ÷ 8048041 × 7959774]. Further, the assessee has also claimed an amount of Rs. 11,56,606 as deduction under section 54F of the Act on account of deposit to an account of specified bank or institution. As per the provisions of section 54F(4) of the Act, the amount of net consideration which was not appropriated by the assessee towards the purchase of new asset made within one year before the date on which the transfer of the original asset took place, or which was not utilized by him for the purchase or construction of the new asset before the date of furnishing the return of income under section 139 of the Act, shall be deposited by him before furnishing such return. Such deposits being made in any case not later than the due date applicable in the case of the assessee for furnishing the return under sub-section (1) of section 139 of the Act in an account in any bank or institution as may be specified. In the instant case, the sale of the original asset took place on 27-9-2012 and the due date for furnishing the return under section 139(1) of the Act was 31-7-2013 whereas the assessee has deposited the amount into the aforesaid account on 24-7-2014, i.e., more than one year beyond the due date for furnishing the return. Thus, the authorities below held that the deduction claimed in respect of this amount could not be allowed.
9. The assessee is in appeal against the order of Commissioner (Appeals).
10. Despite service of notice, none appeared on behalf of assessee. However, we find that the issue stands covered against the assessee by the order of the Hon'ble Bombay High Court in the case of Humayun Suleman Merchant v. CCIT (2016) 73 taxmann.com 2 (Bom.) : 2016 TaxPub(DT) 3850 (Bom-HC).
11. Further, the said proposition laid down by the Hon'ble Bombay High Court in Humayun Suleman Merchant v. CCIT (supra) has been applied by the Pune Bench of the Tribunal (where Judicial Member is a party) in ITA No. 923/PUN/2015 relating to assessment year 2009-10 vide Order, dated 20-12-2017. Vide Para No. 7 of the Order, dated 20-12-2017, the claim of deduction under section 54 of the Act was denied to the assessee as he had not deposited the amount in the capital gains scheme account by the due date of filing the return of income.
12. The issue arising in the present appeal is identical to the issue before the Tribunal and following the same parity of reasoning, we hold that the assessee is not entitled to the claim of deduction under section 54F of the Act as the assessee has failed to deposit the unutilized amount of capital gains in the capital gains scheme account by the date of filing of return of income. Since this issue is settled by the Hon'ble Jurisdictional High Court, hence, the matter is being decided ex parte the assessee. The grounds of appeal raised by the assessee are thus dismissed.
13. In the result, the appeal of assessee is dismissed.

redpajama_set_name: RedPajamaCommonCrawl


text:
N.C. State Delays Opener, Closes Campus Residences
Brock Fritz
The NCAA football schedule remains in flux, as North Carolina State and Virginia Tech have officially postponed their season-opening game two weeks.
N.C. State announced the schedule change Wednesday, noting the decision to move the game in Blacksburg, Va., from Sept. 12 until Sept. 26, was made in conjunction with the Atlantic Coast Conference. The ACC is among the six FBS conferences intending to move forward with football this fall. Both Virginia Tech and N.C. State will open the season Sept. 19.
"The ACC created a league schedule with flexibility to adjust games if needed," N.C. State football coach Dave Doeren said in the release. "There are going to be times teams must adjust based on what is best for the health and safety of the players and staffs involved. This move provides our team and staff the time needed to prepare and reacclimate after pausing our practices."
Related content: College Football Practices Adapt, Pause Amid Positives
According to the North State Journal, N.C. State paused football practice, as well as all other athletic activities, Monday after 22 new positive COVID-19 tests in the athletic department. With the ACC requiring a 10-day quarantine for those that test positive and a 14-day quarantine for those in contact with people that tested positive, N.C. State likely wasn't going to be prepared to play Sept. 12.
N.C. State announced Wednesday that the university in Raleigh is closing on-campus residences beginning Thursday, unless an exception is granted.
"Over the past few days, our campus community has experienced a quickly rising number of positive cases of COVID-19 in both on- and off-campus housing," the university's announcement reads. "We hoped and strived to keep residence halls open and safe to best serve our students. However, the rapid spread and increasing rate of positive cases have made our current situation untenable.
"NC State students who occupy university housing are instructed to schedule a time to move out of on-campus residences, beginning tomorrow, unless an exception is granted. To help ensure physical distancing, move-out will occur over an 11-day period, by appointment, beginning Thursday, Aug. 27, and ending Sunday, Sept. 6."
247 Sports also reported that N.C. State has suspended all 2020 season tickets for football.
"Although a final decision has not been made in regards to fan attendance, we know there will be a significantly reduced capacity for at least some of our games at Carter-Finley Stadium this Fall," the letter from N.C. State athletic director Boo Corrigan to season-ticket holders reads. "As proud as we are of our more than 30,000 dedicated, loyal and passionate season ticket holders, it is now unrealistic for us to expect that we would be able to accommodate a crowd of that size for every game this fall. As a result, we have made the difficult decision to suspend season tickets for the 2020 football season."
Related content: Notre Dame, UNC Pause Workouts After Outbreaks
On the other side of the country, the Los Angeles Times is reporting that the University of Southern California has suspended football and men's water polo workouts until at least Monday after eight athletes between the two teams tested positive Wednesday. The USC, along with the rest of the Pac-12, has already postponed fall sports with the hopes of playing in the spring.
Related content: Big Ten, Pac-12 Cancel Fall Sports
Atlantic 10 Seeks Redshirt Waiver to Bolster Thin Rosters
Meyer: Unaware Trayvon Martin Photo Used in OSU Team Meeting
Sports Tournament Planning Oversights: How to Avoid Common Mistakes
Unique Athletic Scholarship Promotes LGBT+ Inclusion at Colorado


text:
"""
Majordomo Protocol broker
A minimal implementation of http:#rfc.zeromq.org/spec:7 and spec:8

Author: Min RK <benjaminrk@gmail.com>
Based on Java example by Arkadiusz Orzechowski
"""

import logging
import sys
import time
from binascii import hexlify

import zmq

# local
import mdp.MDP as MDP
from mdp.zhelpers import dump

class Service(object):
    """a single Service"""
    name = None # Service name
    requests = None # List of client requests
    waiting = None # List of waiting workers

    def __init__(self, name):
        self.name = name
        self.requests = []
        self.waiting = []

class Worker(object):
    """a Worker, idle or active"""
    identity = None # hex Identity of worker
    address = None # Address to route to
    service = None # Owning service, if known
    expiry = None # expires at this point, unless heartbeat

    def __init__(self, identity, address, lifetime):
        self.identity = identity
        self.address = address
        self.expiry = time.time() + 1e-3*lifetime

class MajorDomoBroker(object):
    """
    Majordomo Protocol broker
    A minimal implementation of http:#rfc.zeromq.org/spec:7 and spec:8
    """

    # We'd normally pull these from config data
    INTERNAL_SERVICE_PREFIX = "mmi."
    HEARTBEAT_LIVENESS = 3 # 3-5 is reasonable
    HEARTBEAT_INTERVAL = 2500 # msecs
    HEARTBEAT_EXPIRY = HEARTBEAT_INTERVAL * HEARTBEAT_LIVENESS

    # ---------------------------------------------------------------------

    ctx = None # Our context
    socket = None # Socket for clients & workers
    poller = None # our Poller

    heartbeat_at = None# When to send HEARTBEAT
    services = None # known services
    workers = None # known workers
    waiting = None # idle workers

    verbose = False # Print activity to stdout

    # ---------------------------------------------------------------------

    def __init__(self, verbose=False):
        """Initialize broker state."""
        self.verbose = verbose
        self.services = {}
        self.workers = {}
        self.waiting = []
        self.heartbeat_at = time.time() + 1e-3*self.HEARTBEAT_INTERVAL
        self.ctx = zmq.Context()
        self.socket = self.ctx.socket(zmq.ROUTER)
        self.socket.linger = 0
        self.poller = zmq.Poller()
        self.poller.register(self.socket, zmq.POLLIN)
        logging.basicConfig(format="%(asctime)s %(message)s", datefmt="%Y-%m-%d %H:%M:%S",
                level=logging.INFO)

    # ---------------------------------------------------------------------

    def mediate(self):
        """Main broker work happens here"""
        while True:
            try:
                items = self.poller.poll(self.HEARTBEAT_INTERVAL)
            except KeyboardInterrupt:
                break # Interrupted
            if items:
                msg = self.socket.recv_multipart()
                if self.verbose:
                    logging.info("I: received message:")
                    dump(msg)

                sender = msg.pop(0)
                empty = msg.pop(0)
                assert empty == ''
                header = msg.pop(0)

                if (MDP.C_CLIENT == header):
                    self.process_client(sender, msg)
                elif (MDP.W_WORKER == header):
                    self.process_worker(sender, msg)
                else:
                    logging.error("E: invalid message:")
                    dump(msg)

            self.purge_workers()
            self.send_heartbeats()

    def destroy(self):
        """Disconnect all workers, destroy context."""
        while self.workers:
            self.delete_worker(self.workers[0], True)
        self.ctx.destroy(0)

    def process_client(self, sender, msg):
        """Process a request coming from a client."""
        assert len(msg) >= 2 # Service name + body
        service = msg.pop(0)
        # Set reply return address to client sender
        msg = [sender,''] + msg
        if service.startswith(self.INTERNAL_SERVICE_PREFIX):
            self.service_internal(service, msg)
        else:
            self.dispatch(self.require_service(service), msg)

    def process_worker(self, sender, msg):
        """Process message sent to us by a worker."""
        assert len(msg) >= 1 # At least, command

        command = msg.pop(0)

        worker_ready = hexlify(sender) in self.workers

        worker = self.require_worker(sender)

        if (MDP.W_READY == command):
            assert len(msg) >= 1 # At least, a service name

            service = msg.pop(0)
            # Not first command in session or Reserved service name
            if (worker_ready or service.startswith(self.INTERNAL_SERVICE_PREFIX)):
                self.delete_worker(worker, True)
            else:
                # Attach worker to service and mark as idle
                worker.service = self.require_service(service)
                self.worker_waiting(worker)

        elif (MDP.W_REPLY == command):
            if (worker_ready):
                # Remove & save client return envelope and insert the
                # protocol header and service name, then rewrap envelope.
                client = msg.pop(0)
                empty = msg.pop(0) # ?
                msg = [client, '', MDP.C_CLIENT, worker.service.name] + msg
                self.socket.send_multipart(msg)
                self.worker_waiting(worker)
            else:
                self.delete_worker(worker, True)

        elif (MDP.W_HEARTBEAT == command):
            if (worker_ready):
                worker.expiry = time.time() + 1e-3*self.HEARTBEAT_EXPIRY
            else:
                self.delete_worker(worker, True)

        elif (MDP.W_DISCONNECT == command):
            self.delete_worker(worker, False)
        else:
            logging.error("E: invalid message:")
            dump(msg)

    def delete_worker(self, worker, disconnect):
        """Deletes worker from all data structures, and deletes worker."""
        assert worker is not None
        if disconnect:
            self.send_to_worker(worker, MDP.W_DISCONNECT, None, None)

        if worker.service is not None:
            worker.service.waiting.remove(worker)
        self.workers.pop(worker.identity)

    def require_worker(self, address):
        """Finds the worker (creates if necessary)."""
        assert (address is not None)
        identity = hexlify(address)
        worker = self.workers.get(identity)
        if (worker is None):
            worker = Worker(identity, address, self.HEARTBEAT_EXPIRY)
            self.workers[identity] = worker
            if self.verbose:
                logging.info("I: registering new worker: %s", identity)

        return worker

    def require_service(self, name):
        """Locates the service (creates if necessary)."""
        assert (name is not None)
        service = self.services.get(name)
        if (service is None):
            service = Service(name)
            self.services[name] = service

        return service

    def bind(self, endpoint):
        """Bind broker to endpoint, can call this multiple times.

        We use a single socket for both clients and workers.
        """
        self.socket.bind(endpoint)
        logging.info("I: MDP broker/0.1.1 is active at %s", endpoint)

    def service_internal(self, service, msg):
        """Handle internal service according to 8/MMI specification"""
        returncode = "501"
        if "mmi.service" == service:
            name = msg[-1]
            returncode = "200" if name in self.services else "404"
        msg[-1] = returncode

        # insert the protocol header and service name after the routing envelope ([client, ''])
        msg = msg[:2] + [MDP.C_CLIENT, service] + msg[2:]
        self.socket.send_multipart(msg)

    def send_heartbeats(self):
        """Send heartbeats to idle workers if it's time"""
        if (time.time() > self.heartbeat_at):
            for worker in self.waiting:
                self.send_to_worker(worker, MDP.W_HEARTBEAT, None, None)

            self.heartbeat_at = time.time() + 1e-3*self.HEARTBEAT_INTERVAL

    def purge_workers(self):
        """Look for & kill expired workers.

        Workers are oldest to most recent, so we stop at the first alive worker.
        """
        while self.waiting:
            w = self.waiting[0]
            if w.expiry < time.time():
                logging.info("I: deleting expired worker: %s", w.identity)
                self.delete_worker(w,False)
                self.waiting.pop(0)
            else:
                break

    def worker_waiting(self, worker):
        """This worker is now waiting for work."""
        # Queue to broker and service waiting lists
        self.waiting.append(worker)
        worker.service.waiting.append(worker)
        worker.expiry = time.time() + 1e-3*self.HEARTBEAT_EXPIRY
        self.dispatch(worker.service, None)

    def dispatch(self, service, msg):
        """Dispatch requests to waiting workers as possible"""
        assert (service is not None)
        if msg is not None:# Queue message if any
            service.requests.append(msg)
        self.purge_workers()
        while service.waiting and service.requests:
            msg = service.requests.pop(0)
            worker = service.waiting.pop(0)
            self.waiting.remove(worker)
            self.send_to_worker(worker, MDP.W_REQUEST, None, msg)

    def send_to_worker(self, worker, command, option, msg=None):
        """Send message to worker.

        If message is provided, sends that message.
        """

        if msg is None:
            msg = []
        elif not isinstance(msg, list):
            msg = [msg]

        # Stack routing and protocol envelopes to start of message
        # and routing envelope
        if option is not None:
            msg = [option] + msg
        msg = [worker.address, '', MDP.W_WORKER, command] + msg

        if self.verbose:
            logging.info("I: sending %r to worker", command)
            dump(msg)

        self.socket.send_multipart(msg)

def main():
    """create and start new broker"""
    verbose = '-v' in sys.argv
    broker = MajorDomoBroker(verbose)
    broker.bind("tcp://*:5555")
    broker.mediate()

if __name__ == '__main__':
    main()

redpajama_set_name: RedPajamaGithub


text:
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Wizz Air is closing in on becoming a low-cost market leader
Low-cost airline Wizz Air is making strides to take one of the top spots in what is a competitive market for budget carriers, according to GlobalData.
After picking up another 15 slots at Gatwick due to Norwegian Air declaring bankruptcy in 2020, Wizz Air is closing in on Europe's leading budget carriers as the airline industry prepares to progress into an unpredictable 2022.
While many airlines have looked to scale-back operations during the pandemic downturn, Wizz Air has attempted to expand routes and develop new markets. Since 2020, according to its website, the low-cost airline has developed routes to the Middle East, Italy, Ukraine, Spain, and the UK, from airports all over Europe.
Wizz Air's expansion demonstrates its financial resilience
The budget carrier has been ruthless in its expansion, taking advantage of pandemic-related bankruptcies to Alitalia, Flybe, and Norwegian Air, amongst many others. All in all, 220 new routes were added in 2020, highlighting its ambition.
Wizz Air has not shied away from possible merger and acquisition activity either, after a failed takeover bid of Europe's second-largest low-cost airline, easyJet. Furthermore, in October 2021, Wizz Air CEO József Váradi said that the airline was open to acquisitions.
This announcement provides insight into the carrier's future strategic direction. During times of financial hardship, consolidation is expected in the travel industry. Therefore, we will likely see developments in this area over the next few years.
M&A activity in the airline industry after the 2009 global recession is a recent example of this, where US carriers such as United and Continental Airlines merged in order to strengthen their presence in the market.
Wizz has proven itself to be one of the few financially robust aviation companies throughout the pandemic, allowing it to lay the foundations for future growth. In June 2020, Váradi highlighted that the airline was one of the strongest in the world in terms of liquidity. As a result, it had a large amount of free-flowing capital to tackle the pandemic, enabling it to respond quickly to changes in demand.
The low-cost market is still in high demand
Low-cost travel will be a major trend in travel and tourism as the pandemic eases. According to a GlobalData survey, 53% of respondents said affordability was the biggest influencing factor when choosing a holiday, while 51% said that accessibility was the most important.
Wizz Air's low-cost product and expansive route network are well-positioned to capture future demand.
However, while its future looks positive, it must battle with easyJet and Ryanair, two more experienced players when it comes to weathering unpredictable markets. Furthermore, the launch of new Icelandic budget carrier PLAY Airline, the relaunch of Flybe and the creation of BA's new low-cost airline, Euroflyer (due to begin operations in March 2022) will create a challenging environment for Wizz Air, which could drive down fares even further.
Nevertheless, if Wizz Air continues on its current path and maintains its positive growth strategy, it could emerge as Europe's leading low-cost airline in years to come.
Main image credit: Uhryn Larysa


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text:
Freddy Maertens (nacido el 13 de febrero de 1952 en Nieuwpoort) fue un ciclista belga, profesional entre los años 1972 y 1987, durante los cuales logró 221 victorias. Fue dos veces campeón del mundo y consiguió ganar la Vuelta a España en una ocasión, además de lograr triunfos de etapa en las tres Grandes Vueltas (15 en el Tour, 13 en la Vuelta y 7 en el Giro).

Biografía
Como ciclista amateur logró 51 victorias, entre las cuales destacan el primer puesto en el campeonato de ruta de su país y la medalla de plata en el Campeonato del Mundo, ambos resultados conseguidos en 1971.

Durante sus primeros años como profesional, cosechó gran cantidad de triunfos en competiciones de un día y en carreras de corta duración de mediano prestigio como la Vuelta a Luxemburgo, la Vuelta a Bélgica, los Cuatro días de Dunkerque o la Vuelta a Andalucía. Asimismo, se desveló como un ciclista con un importante futuro por delante al conseguir puestos de honor en algunas de las competiciones más importantes del circuito internacional ya desde el año de su debut, en el que fue segundo en el Campeonato del Mundo y el Tour de Flandes, incluyendo diversas pruebas de reconocido prestigio, como los Monumentos, si bien a pesar de los buenos resultados, nunca logró ganar ningún Monumento en su carrera como ciclista.

En los años siguientes fue destacando también en competiciones por etapas de mayor calibre, como el Dauphiné Libéré o la París-Niza.

En 1972 participó en los Juegos Olímpicos de Múnich. En 1975 consiguió el récord Ruban Jaune otorgado al ciclista más rápido en ganar una prueba de más de 200 km, al ganar la París-Bruselas.

1976 fue su primer gran año, en el cual logró vencer en una serie de grandes clásicas como la Amstel Gold Race, el Campeonato de Zúrich y la Gante-Wevelgem, aparte de muchas otras. Destacó en competiciones por etapas menores como la Vuelta a Suiza y la París-Niza y brilló en el Tour de Francia, donde ganó ocho etapas, la clasificación por puntos y fue 8.º en la general. Ese mismo año, fue campeón de Bélgica y del Mundo de ruta.

En 1977 logró una abrumadora victoria en la Vuelta a España. Fue líder de principio a fin y ganó trece etapas (récord aún no igualado), la clasificación de las metas volantes y la clasificación por puntos . También ganó la París-Niza (cinco etapas y la clasificación por puntos), la Volta a Cataluña (cinco etapas y la clasificación por puntos), la Semana Catalana (cuatro etapas y la clasificación por puntos) y siete etapas del Giro de Italia.

En 1978 volvió a vencer en la clasificación por puntos del Tour de Francia, junto a dos triunfos parciales. Logró buenos resultados en clásicas de un día pero no consigue igualar a los dos fantásticos años anteriores en triunfos.

En general, los resultados son peores que en años anteriores, y 1981 fue su último gran año como profesional, logrando cinco triunfos de etapa y la clasificación por puntos del Tour de Francia y la medalla de oro en el Campeonato del Mundo por segunda vez.

Desde entonces y hasta su retirada, no consiguió ninguna otra victoria de renombre.

Palmarés

Resultados

Durante su carrera deportiva ha conseguido los siguientes puestos en Grandes Vueltas y carreras de un día:

Grandes Vueltas

Clásicas, Campeonatos y JJ. OO.

—: No participa
Ab.: Abandona
X: Ediciones no celebradas

Reconocimientos
 Mendrisio de Oro (1976)
 En 2002 pasó a formar parte de la Sesión Inaugural del Salón de la Fama de la UCI.

Referencias

Bibliografía
 "Fall From Grace", Freddy Maertens y Manu Adriaens, 1993, Ronde Publications.

Enlaces externos

 Página oficial de la clásica Freddy Maertens
Biografía e imágenes de Freddy Maertens
Freddy Maertens gana la Vuelta a España de 1977 y bate todos los registros (crónica)

Campeones mundiales de ciclismo en ruta
Ganadores de la Vuelta a España
Ganadores de etapa en el Giro de Italia
Ganadores de etapa en el Tour de Francia
Ganadores de etapa en la Vuelta a España
Ganadores de etapa en las Tres Grandes Vueltas
Ciclistas de Bélgica en los Juegos Olímpicos de Múnich 1972
Belgas del siglo XX

redpajama_set_name: RedPajamaWikipedia


Asterisk (*) denotes Canadian artists. All !earshot charts in this issue reflect actual airplay on campus/community stations during the month of December 2004. Charts are weighted according to broadcast range and market size. To view older charts from as far back as 1999, go to our charts archive.
125 Sons And Daughters Love The Cup Ba Da Bing!


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text:
Interview with outgoing US ambassador David Reimer | 05 July 2019
'We would like to see better economic relations, more American investors and goods here'
The outgoing United States ambassador to the Republic of Seychelles, David Reimer, has described the relationship between the US government and that of Seychelles as good and getting better.
He said the US
"I think the last year and a half we've really increased the amount of activity we have here in Seychelles and increased our collaboration on a number of areas especially in maritime security apart from other areas as well,"
243rd anniversary of US independence celebrated | 03 July 2019
'Seychelles and the USA nurture a long friendship of shared values and common aspirations,' says VP Meriton "The United States of America and the Republic of Seychelles...
Nation 2019-07-03
243rd independence anniversary of the United States of America | 02 July 2019
US ambassador hosts dignitaries to reception The United States ambassador to the Republic of Seychelles, David Reimer, hosted dignitaries in Seychelles to a reception...
Security standards at Port Victoria to improve | 01 July 2019
"The government of Seychelles remains committed to securing our port and main gateway to the world," Tourism, Civil Aviation, Ports and Marine Minister Didier Dogley has...
Exclusive interview with outgoing Ambassador of the European Union to Seychelles, Marjaana Sall | 26 ...
'I will be leaving Seychelles knowing that the EU-Seychelles friendship is a solid one' Before ending her four-year stint as Ambassador of the European Union to Seychelles,...
Seychelles and US sign Foreign Account Tax Compliance Act | 02 July 2019
American companies and individuals doing business transaction and holding an account in Seychelles will find it harder or impossible to evade paying taxes now that the US and Seychelles governments have signed the Foreign Account Tax Compliance Act (Fatca). The documents were signed on behalf of the Seychelles government by the Minister for Finance, Trade, Investment and...
Correcting a Colonial Injustice: The Return of the Chagos Islands to Its Natives
The correction of this injustice has been achieved through a long drawn fight, somewhat of a David and Goliath contest. The outcome, culminating in a spectacular opinion and vote, has a number of consequences that can impact a rules-based international order, a commitment promoted by the UN Charter which specifically seeks to 'establish conditions under which justice and...
Reception in honour of the Prime Minister of St. Vincent and the Grenadines, Dr Ralph ...
'Our island nations are linked by bonds of our shared history,' says President Faure "Our island nations, although oceans apart, are linked by the powerful bonds of our shared history, our common language, and our strong cultural links." President Danny Faure said this in his speech during the banquet he hosted at State House on Friday in honour of the Prime Minister of St...
State visit of the Prime Minister of St. Vincent and the Grenadines, Dr Ralph Gonsalves ...
'Seychelles is really one of the cleanest places I've ever been to in the world' Invited to Seychelles as guest of honour for the country's 43rd Independence Day anniversary and National Day celebrations, Prime Minister of St Vincent and the Grenadines, Dr Ralph E. Gonsalves described Seychelles as "one of the cleanest places I've ever been to in the world". PM Gonsalves...
Harmony in multi-ethnic Seychelles is threatened | 06 July 2019
Scholars of ethnicity will tell you that a balance of races of people living together is required to ensure peace and harmony prevails in a country. As soon as this balance swings in the direction of one group of nationals living next door to each other, problems begin; the dominant group start to feel high and mighty and the smaller groups feel threatened so they start to...
ISS is the examination test centre for entry into US universities | 12 July 2019
Seychellois and foreigners in Seychelles who aspire to enter into universities in the United States of America (USA) can do their entry exams here now that a test centre has been set up through the International School Seychelles (ISS). The announcement was made with great pleasure by Dr Iqbal Maherally, the education USA advisor based in Mauritius, in a press conference at ISS...


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You are at:Home»Innovative ETFs Channel»Get Low-Cost, Pure-Play Diversification Outside North America With This ETF
Innovative ETFs Channel
Get Low-Cost, Pure-Play Diversification Outside North America With This ETF
The Omicron variant introduced a new challenge for investing into an already-tricky international market outside North America, but it doesn't have to be difficult with the right exchange traded fund (ETF).
Investors will often flock to international opportunities overseas in order to maximize gains while adding more diversification. That said, however, the international markets present their own set of risks that investors must take into account.
"The key to wise investing lies in your ability to minimize risks while maximizing the returns successfully," notes a Finance Magnates article. "It also requires that the diversification of your portfolio involves some stable securities that are balanced by rapidly-developing assets."
"With a proper asset mix, you have an excellent chance of making more money while participating in a thrilling and fast-growing investment space that offers a broad range of options," the article says further. "Geographical diversification is when investors invest across geographic regions to curb risk and boost returns."
Getting that added dose of diversification is key to avoid over-concentrating assets in one specific geographic region. International markets can get volatile, so risk management is always imperative, especially when venturing overseas.
"Such a practice allows you to access and bet on various types of global market investments," the article notes. "It also reduces your exposure to domestic exchanges and expands it across different markets, helping mitigate the impact of volatility."
"ETFs or mutual funds that invest in international funds can indirectly help you invest across world markets," Finance Magnates says. "There are mutual funds that invest in more than one ETF or index funds or securities overseas, which can provide you indirect access to foreign markets."
Pure Play at Low Cost
One such ETF is the Invesco PureBeta FTSE Developed ex-North America ETF (PBDM), which, as the name implies, gives ETF investors exposure to markets outside of North America at a total expense ratio of just 0.07%. The fund seeks to track the investment results (before fees and expenses) of the FTSE Developed ex North America Index.
The fund generally will invest at least 90% of its total assets in common stocks that comprise the underlying index, as well as ADRs and GDRs that represent securities in the underlying index. The index is designed to measure the performance of the large- and mid-capitalization segments of equity markets of countries around the world that are classified as developed markets within the country classification definition of the index provider, excluding the United States and Canada.
For more news, information, and strategy, visit the Innovative ETFs Channel.
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text:
Grant Enfinger, Christopher Bell, Matt Crafton top first Truck practice at Atlanta
By Jerry BonkowskiFeb 26, 2016, 11:36 AM EST
Friday's first NASCAR Camping World Truck Series practice at Atlanta Motor Speedway was a tale of two rookies.
Grant Enfinger, defending ARCA Series champ, and Christopher Bell were fastest in the first of three practice sessions today.
Enfinger had a best run of 179.574 mph to top the field. Bell, who suffered a hard wreck at Daytona last week, was second fastest at 178.816 mph.
Two-time Truck champ Matt Crafton was third fastest at 178.310 mph.
Friday's two other sessions will be at 1:30 p.m. to 2:25 p.m. and 4 p.m. to 5:25 p.m. ET.
Here's how the first session played out:


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Q: for statement (looping calculation priority)*not sure if this is the correct term prices = {
    "banana": 4,
    "apple": 2,
    "orange": 1.5,
    "pear": 3
}

stock = {
    "banana": 6,
    "apple": 0,
    "orange": 32,
    "pear": 15
}
total = 0

for item in prices:
    a=prices[item]*stock[item]
    total=total+a
    print total

so here is my code, i intentionally wrote the print total within the for statement, so it print out the order of calculation for me and the number goes like this 48.0
93.0 117.0 117.0, so after the basic calculation the first value that the statement churns out is the total of orange the second is the total of pear the third is the banana and the last is the apple
now i am curious under what principle is this precedence of calculation carried out cause it seems to me that it started with the largest number in dic_stock and calculated in a descending manner, i do aware this is just a superficial observation,there must be a reason why computer did this
can anyone tell me why :)

A: Dictionaries are not ordered. So, the ordering in which you get the key-value pair is not fixed.
If you need to define insertion order on your dict, you need to use collections.OrderedDict

redpajama_set_name: RedPajamaStackExchange


The main function of spring nurse crops is for weed control. Fall nurse crops, on the other hand, also serve as a buffer against frost and the cold, but in the spring, this is not a threat. Oats or a spring barley are typically used because they jump out of the ground quicker than the perennial species. Nurse crops are recommended for seedings going in the fields especially after winter annuals and even lawns have begun to green up. From this point forward, it is highly suggested. Nurse crops in grazing pastures can add the benefit of more forage for the first grazing as well but be sure to only graze lightly so as not to damage the perennial grasses still developing. Be sure to keep an eye on your nurse crops though. If you feel that the seeding rate turned out a bit heavier than you had hoped and the nurse crop is creating too much competition, clip the oats to the height of the perennial stand coming through to reduce the competition.
Keep in mind that your drill set-up also plays into the need for a nurse crops. 7.5 inch rows leave a large section of unseeded soil vulnerable to weeds. Nurse crops help shade over this area until the perennial stand thickens. 5.5 inch rows are more ideal for perennial grasses since it leaves less space between rows for weeds to germinate. Some farmers will even plant their field in a crisscross pattern to reduce the space between rows even further. If you use this method, make sure to cut the seeding rate in half since you will be making two passes. A mat of burned down rye, wheat, or triticale can also work to control weeds for your new seeding.
EVERLEAF: A true, high quality forage oat with delayed heading. This is an excellent choice to pair with a new alfalfa stand. Seed at 20-25 lbs per acre.
CDC HAYMAKER: A very leafy, high quality oat. CDC Haymaker is a great fit for producers looking for a bit of extra high-quality forage to graze during the first grazing. Seed at 20-25 lbs per acre.
NIAGARA: A tall, western oat with improved rust resistance. A good choice for a standard nurse crop. Seed at 30-40 lbs to the acre.
PROLEAF 234: A medium maturing variety, also a good choice for a standard nurse crop. Seed at 30-40 lbs to the acre.


In this weeks' episode we preview a flavour of the main events on the Isle of Wight in 2016 and what you can look forward to if you live on the Island or are planning to visit.
In our last episode of the Podcast we reviewed a number of Isle of Wight Ale's but completely missed one of the main breweries, the Isle of Wight Brewery, which just happens to make the award winning Wight Christmas. So in the spirit of balance we review the Wight Christmas Ale in today's episode.
In this weeks' super fun Christmas episode we bring you a review of some of the finest real Ale's produced on the Isle of Wight.
In this weeks' episode we bring you a review of the Needles Pleasure Park which we have visited in the summer and for one of their Christmas special weekends.
Ali's News is about success for local businesses at the Beautiful South Awards.
Tony has news about a derelict holiday camp with planning permission for redevelopment, Southern Vectis scoop an award and a charity fund raising attempt to stay awake for 36 hours.
In the food and drink segment we review the End of the Line Cafe, Freshwater a lovely cafe with scenic walks and a garden centre near by.


Color: Grey black and white.
Found in our shared yard. Mostly white with dark grey spots. Female I believe. Very sweet kitty who I can tell is lost. She wants to come inside but we have two already. Left some dry food and water and a crate with the door open for shelter tonight. Will call and attempt to locate owner in the morning.


text:
7 Oscar-nominated films that were also great investments this year
Elena Holodny
Aidan Monaghan/20th Century Fox
FA Insights is a daily newsletter from Business Insider that delivers the top news and commentary for financial advisors.
7 Oscar-nominated films that were the best investments this year (Wealth Management)
"Like art, investing in movies can be a tricky business... but for some high-net-worth individuals, this alternative investment might make sense," writes Diana Britton.
In light of that, Britton shared the top Oscar-nominated films ranked by their return on investment: 1) Star Wars: The Force Awakens, 2) Straight Outta Compton, 3) The Martian, 4) Inside Out, 5) Creed, 6) Brooklyn, 7) The Big Short.
A Brexit "would have ramifications well beyond the UK's borders" (Advisor Perspectives)
"Although the UK is often a difficult bedfellow for its Continental partners, leaving the EU would represent a huge setback for the European 'project,'" writes AllianceBernstein's Darren Williams. "It would embolden populist/anti-EU parties in other countries, and remind investors that EU (and euro-area) countries are still sovereign nations and that nothing is 'irrevocable.'"
"In the wake of the sovereign-debt crisis, and with the migrant/refugee crisis fanning popular discontent and exposing long-buried fault lines across Europe, it could kick off the most challenging period yet for the EU and its French and German leaders," he added.
Rich investors are more familiar with robo advising (IMS Wealth Management)
New data from Investing Media Solutions suggests that many investors still aren't that familiar with robo advisors: 49% of respondents in a survey were not aware of the term "robo advisor" at all despite the fact that major financial brands like Fidelity, Vanguard, and Charles Schwab are entering the space.
However, wealthy investors were more in the know when it came to robo advising: 71% of those with over $5 million in non RE investable assets were aware of the term, and 57% of those with over $250,000 were.
High-Yield bonds may look attractive, but... (Charles Schwab)
"High-yield bonds may look appealing, but they come with additional default and volatility risks. If you decide to invest in high-yield bonds, understand the risks and be sure your bond portfolio is diversified enough to cushion the impact of a default," writes Collin Martin.
"One way to help manage high-yield bond risks is by investing through a professional manager, such as a mutual fund, exchange-traded fund or separately managed account," he suggests.
Raymond James has to pay about $600,000 to a former client (Financial Planning)
An arbitration panel order Raymond James to pay almost $600,000 to a former client, David Silipigno, who sought damages after alleged breach of fiduciary duty, churning, suitability, and other misconduct, reports Andrew Welsch.
Still, this was less than what Silipigno originally sought: $18 million in damages from the firm.
SEE ALSO: The famous last words of 18 famous people
More: Financial Advisor Insights


Our saying this week builds on the sayings we've discussed over the last three weeks: Loving Your Enemies, Renouncing One's Rights, and The Golden Rule.
This week's saying addresses those in Jesus's audience who might have accepted his teaching on the Golden Rule, but only for those who would do the same for them.
These audience members would have reduced the Golden Rule to reciprocity: an exchange between equals for one's own advancement and benefit. For them, the Golden Rule could have been co-opted to mean only "getting ahead" and not a way to make the world a safer, more compassionate world for us all.
This quality of reciprocity is quite different from the ethic we are considering this week. The Sayings Gospel Q teaching is about loving those who cannot offer us anything in return. There is no quid pro quo here.
As we'll see in the weeks to come, Jesus uses the Golden Rule to inspire a domino-effect in those who receive love to then turn and practice that love in their relations with others. The Golden Rule wasn't designed to establish private relationships of mutual benefit between two individuals, but to produce a whole new world where everyone treats everyone as they'd like to be treated even when there's nothing gained in return. Love was to be reciprocated, but more importantly, love was to be shared with other people.
This distinction is foundational to the rest of Jesus's teachings in Sayings Gospel Q. The Golden Rule is not merely or exclusively between a loving person and a loved person. It's between the loved person and another person in need of love, as well. The person who receives this kind of impartial love is called upon to reciprocate by indiscriminately loving a third person, and through their love, what Jesus calls "God's reign" transforms the world and enlarges continuously from each person to the next.
In Sayings Gospel Q, the reign or kingdom of God begins with love even when we have nothing to gain.
I need to say a word about the comparisons in this week's texts and the text references to Gentiles, tax collectors, sinners, and pagans. As we covered last week, when these texts were written, the school of Shammai dominated both the Pharisees and the Sanhedrin. In an effort to strengthen Jewish identity and culture, the School of the Shammai drew a sharp line between Jews and Gentiles, and prohibited the people from crossing that line.
In this 1st Century context, Hillel taught that every person bore the image of the Divine, and worshipping God was revealed in how one treated another regardless of whether they were Jew or Gentile. But Shammai sharply distinguished between Jew and Gentile—we could call it "Jewish pride" or "Jewish Power"—and his school framed it as a matter of Jewish survival while the Jewish self was being denied by Roman oppression. In our time, James H. Cone in his book Black Theology and Black Power, within the context of his own experience, rightly rejects defining Black Power as an effort to "assert their right to dominance over others because of a belief in black superiority . . . Black Power is an affirmation of the humanity of blacks in spite of white racism." (Black Theology and Black Power, p.14-16, emphasis added.) The same could be said regarding LGBTQ Pride as a necessary expression of affirming the humanity of those whose humanity has been denied by the dominant sector of society. Protesting Jewish subjugation in the context of the Jesus story could very easily be seen as a Jewish Lives Matter movement within early first century Palestine.
Jesus does not condemn the School of Shammai's survival technique in our saying this week. His Jewish listeners did not need to have their self further denied: their oppressors were already doing that. They needed their self affirmed and liberated from oppression. While supremacy anywhere in society opposes egalitarianism, feelings of supremacy in the hearts of oppressors are of a markedly different quality than claims of superiority oppressed people might make.
Jesus does push back on his audience's claim to be superior while using the oppressor's ethics. When they loved only those who loved them, Jesus said, their morality was no greater than their oppressors' morality. For Jesus, failing to love people who might never give anything in return negated any claim to moral superiority. If the "Jewish Pride" and "Jewish Power" movements of his day would enter into the new human society they were seeking to establish, it would not be through more disconnectedness, but through endeavoring to embrace humanity's interconnectedness and interdependence. In other words, in response to a "Jewish Lives Matter" statement, Jesus as a fellow Jew is not disregarding their daily struggle to survive by responding, "No, All Lives Matter." To the contrary, he is saying, "Yes, Jewish lives DO matter! And if our liberation is going to made a reality, we must live by set of ethical teachings greater than those presently adhered to by our oppressors!" The teaching we are looking at this week asks us to live from the truth of interconnectedness by taking care of those from whom we will never receive anything in return.
Remember: according to Jesus, the reign of God was shown in people taking care of people.
We have spoken about Hillel's prozbul enough over the last few weeks that I won't detail it this week. Where Jesus mirrors the school of Hillel in their broader interpretation of Torah, Jesus pushes them even further on economics.
Jesus's economics, in harmony with the Deuteronomic code (Deuteronomy 15:9), called the wealthy elite to lend even if the sabbatical year was approaching and to expect their loans not to be repaid.
To lend knowing that all debts would be cancelled in the Sabbatical year and your money would never repaid was a pathway toward wealth redistribution and a way to eliminate poverty among the Jewish people (see Deuteronomy 15:4). Today, some fear "socialism" or "communism" yet wealth redistribution from the wealthy to the poor was central to Jesus's economic teachings in Sayings Gospel Q. He taught his followers to lend even if they would never get their capital back.
In Sayings Gospel Q, we are called to love indiscriminately and impartially. Jesus calls us to love in a way that mimics a God who "raises the sun on bad and good and rains on the just and unjust" (Sayings Gospel Q 6:27-28, 35c-d). Any partiality perpetuates the disconnectedness that pervades our planet.
The answer is to see that we are all interconnected and to love based on that, even if there is no immediate return on our relational investment. The goal is what Jesus called "the reign of God" where people, rather than dominating one another, learn to take care of and provide for one another.
This week I want you to spend some time contemplating the nature of impartial love.
What does it look like for you to love impartially? What does it look like to help others in need when there is no hope of them ever returning the favor? What does it look like to love in moments when the cost of that love will never be repaid? And just because the love is not reciprocally repaid does that mean that the world created by the act has no overall reciprocal value in return?
If you were part of the wealthy elite of Jesus's day, how would you have felt about loaning your wealth even if your loan would be cancelled and never repaid?
Discuss with your HeartGroup relational and economic ways to apply impartial love toward others. Choose to practice one of those applications.
Again, I'm so thankful that you are joining us for this series.
Until next week, keep living in love, till the only world that remains is a world where only love reigns.


text:
Czaplinek  (tyska: Tempelburg) är en stad i nordvästra Polen, belägen i distriktet Powiat drawski i Västpommerns vojvodskap, omkring 140 km öster om Szczecin. Befolkningen uppgår till 7 184 invånare (juni 2013). Staden är huvudort för en stads- och landskommun med samma namn.

Sevärdheter
 Stadens historiska stadskärna.
 Heliga trefaldighetskyrkan från 1200-talet, ombyggd 1725, med en klockstapel från 1700-talet.
 Heliga korsets upphöjelse-kyrkan, uppförd 1829 som protestantisk kyrka, idag katolsk kyrka.
 Rådhuset från 1845.
 Judiska kyrkogården.

Näringsliv
Kabelteknikföretaget KTP är en av regionens största arbetsgivare, och hade 2012 omkring 1 700 anställda. I staden tillverkas framförallt kablar för fordonsindustrin, maskin- och byggsektorn samt kopplingsskåp. Företaget såldes 2015 av Groclin group till finska PKC group.

Vänorter
Staden har följande tyska vänorter:
 Bad Schwartau, Schleswig-Holstein
 Grimmen, Mecklenburg-Vorpommern
 Lychen, Brandenburg
 Marlow, Mecklenburg-Vorpommern
 Ratekau, Schleswig-Holstein

Källor

Noter

Externa länkar

Städer i Västpommerns vojvodskap
Kommuner i Västpommerns vojvodskap


text:
Home AS568 O-Rings (Inch) Buna-N O-Rings 50 Durometer Extra Soft -100 Series - 0.103 - 3/32" CS
50 Durometer, Commercial Grade Soft Buna-N O-Rings
Designed for applications requiring soft O-Ring sealing material. Primarily used as a low pressure static seal or gasket. Buna-N compound materials are "standard" for most O-Ring service. While they are not as strong as other Buna-N O-Rings, Soft Buna-N O-Rings require less force to make an effective seal and conform better to uneven surfaces. They are suitable for a broad range of fluids including oils, water, and mild chemicals.
[ View All ] 1 2 3 [Next »]
AS568-102 B50 (NBR) Buna-N Nitrile 50 Duro O-Ring
1/16"ID X 1/4"OD X 3/32"CS Buna-N O-Rings 50 Duro (NBR): The most commonly used elastomer for sealing products. Nitrile, also known as...
Min Qty: 16,667
16667-21,874 $0.03
21,875-138,888 $0.024
138,889+ $0.018
3/32"ID X 9/32"OD X 3/32"CS Buna-N O-Rings 50 Duro (NBR): The most commonly used elastomer for sealing products. Nitrile, also known...
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34-21,874 $0.03
5/32"ID X 11/32"OD X 3/32"CS Buna-N O-Rings 50 Duro (NBR): The most commonly used elastomer for sealing products. Nitrile, also known...
Buna-N O-Rings 50 Duro (NBR): The most commonly used elastomer for sealing products. Nitrile, also known as Buna-N or NBR, is a copolymer of...
1/2"ID X 11/16"OD X 3/32"CS Buna-N O-Rings 50 Duro (NBR): The most commonly used elastomer for sealing products. Nitrile, also known...
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13,125-83,333 $0.04
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Situated at 600 metres above the s.l. , surrounded by the vineyards of the " Muscat", in a quiet sun place, you will be really in the middle of Aosta valley. We are close to Aosta,Cervinia and Pila sky station,many many mountains, forests and to many medievals castles. Every room has its bathroom and balcony, between 1 and 4 beds and you could stay in the garden having your relax time . For breakfast you will have a large traditional food(our BIO honey, our sweet bread,special Katia's pies...) with an italian coffee or cappuccino.
And you may have restaurants, trattoria or Agritourisms really close to us.


text:
Monte Carlo modeling of the response of NRC's Sr 90 /Y 90 primary beta standard
Monte Carlo modeling of NRC's primary standard
Resolve DOI: https://doi.org/10.1118/1.1997347
Search for: Selvam, ST. Palani; Search for: Saull, P.R.B.1; Search for: Rogers, D.W.O.
National Research Council of Canada
The BEAMnrc/EGSnrc Monte Carlo code system is employed to develop a model of the National Research Council of Canada primary standard of absorbed dose to tissue in a beta radiation field, comprising an extrapolation chamber and Sr 90 /Y 90 beta source. We benchmark the model against the measured response of the chamber in terms of absorbed dose to air, for three different experimental setups when irradiated by the Sr 90 /Y 90 source. For the first setup, the chamber cavity depth is fixed at 0.2cm and the source-to-chamber distance varied between 11 and 60cm . In the other two cases, the source-to-chamber distance is fixed at 30cm . In one case the response for different chamber depths is studied, while in the other case the chamber depth is fixed at 0.2cm as different thicknesses of Mylar™ are added to the front surface of the extrapolation chamber.
09759119-c851-468a-9d08-bde1c72fb1b1


None. Last shown in UK cinemas on 23rd March 2017.
Use our reminder system to get a e-mail when Raees is next showing in a UK cinema near you.
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Click here to review/comment on Raees.


Ragnarok is rated 4.7 out of 5 by 3.
Flexible Character Development System - Characters earn both Status and Skill Points each time they gain a level, and these points can be allocated to customize the skills across a wide range of different job classes such as Swordsman, Thief, and Merchant.
Upgradeable Weapons and Armor - Characters' armor and weapons can be upgraded by a blacksmith, or by affixing effect cards dropped by defeated monsters. Blacksmith upgrades will improve an item's overall stats, while effect cards boost specific features.
Game Play Optimized for Touchscreen - All attacks and commands are performed on the Touchscreen. Slash with the stylus to attack with your sword, and circle or tap the intended target to unleash magic spells.
Wireless Party-based Multiplayer - Players can take on the Tower of Mirages with up to 2 other friends using DS Wireless Play or Nintendo Wi-Fi Connection. With more than 50 floors, randomly generated maps and completion conditions, and the chance to obtain rare items, players can enjoy this feature long after the main story has been completed.


Thank you for your inquiry. This Rare Pear-Shaped Fancy Intense Blue Diamond Ring has been sold. While each One and Only One™ Diamond is incredibly rare, we will make every effort to source a Rare Pear-Shaped Fancy Intense Blue Diamond Ring of similar size for your consideration.


SONGKHLA: Police have arrested a man with 651 kilograms of Malaysia-bound crystal meth (ya ice) worth B520 million in Songkhla province and then caught his accomplice in Phitsanulok province.
Lt Gen Ronasilp Phusara, chief of the Provincial Police Region 9, told a press conference today (Apr 2) in Hat Yai district that police seized the drugs from Samphan sae Harn, 29, and Baramee Yangcharoensap, 37. Both are natives of the northern province of Phrae.
Apart from the drugs, they seized two pickup trucks and three mobile phones from them.
Samphan was arrested in front of a Shell petrol station on Asian Highway in tambon Tha Chang of Bang Klam district in the southern province at about 1am on Saturday (Mar 31). He was driving a pickup truck at the time.
Police later caught Baramee at a checkpoint in tambon Wat Bot of Wat Bot district, the northern province of Phitsanulok, on the same day.
Police Lt Gen Ronasilp said both suspects carried the drugs from the North and were supposed to wait in Songkhla for others in their network to take them to southern border provinces and then Malaysia.
The suspects were part of a major transnational drug network called Phor Liang Tee. The racket involved 12 already identified traffickers in Thailand and Malaysia, the regional commissioner said.
Did anyone actually open the packages, to prove they contained drugs, being slightly suspicious, of thai authorities, these could simply be propaganda packages, same as multiple weapons seized on any crack down, but can't be found any other time.
What is the purpose of let staff putting tables in the street and carry out and show the seized drugs?
I think many people like to see pictures sometimes of drugs destruction happening instead of this street table show.
Convince the public that not a bit of this catch finds it's way to the streets through official 'back doors'.
Wow...good haul!  That is a lot of poison, and Malaysia should be grateful.  These guys should be out of commission for at least 25 years, but doubt that will happen.  Just too much money floating around a trans-national drug network.