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Centre for Quaternary Research
Book/Report → Book → Commissioned report Non-textual form → Data set/Database Thesis → Doctoral Thesis Contribution to journal → Article → Comment/debate → Book/Film/Article review → Literature review → Editorial → Special issue → Meeting abstract → Review article Contribution to conference → Paper → Poster → Abstract Contribution to non-peer-reviewed publication → Internet publication Chapter in Book/Report/Conference proceeding → Chapter → Entry for encyclopedia/dictionary → Conference contribution → Chapter (peer-reviewed)
Response of Chrysomelidae to Quaternary environmental changes.
Elias, S. & Kuzmina, S., 2008, Research on Chrysomelidae. Jolivet, P., Santiago-Blay, J. & Schmitt, M. (eds.). Brill, Vol. 1. p. 167-186
Setting the context
Lowe, J., Palmer, A. & Macleod, A., 2008, The Quaternary of Glen Roy and Vicinity. Palmer, A., Lowe, J. & Rose, J. (eds.). London: Quaternary Research Association, London, p. 8-35 27 p. (Quaternary Research Association Field Guide).
Synthesis and wider perspective
Lowe, J. & Palmer, A., 2008, The Quaternary of Glen Roy and vicinity: Field Guide. Quaternary Research Association, London., p. 190-196
Tephrostratigraphical investigations of the basal sediment sequence at Loch Etteridge
Lowe, J., Albert, P., Hardiman, M., Blockley, S., Macleod, A. & Pyne-O'Donnell, S., 2008, The Quaternary of Glen Roy and Vicinity. Palmer, A., Lowe, J. & Rose, J. (eds.). London: Quaternary Research Association, London, p. 60-65 6 p. (Quaternary Research Association Field Guide).
Tephrostratigraphy of the Loch Laggan East lake sequence
MacLeod, A., 2008, The Quaternary of Glen Roy and Vicinity. Palmer, A., Lowe, J. & Rose, J. (eds.). London: Quaternary Research Association, London, p. 83-91 9 p. (Quaternary Research Association Field Guide).
The Earliest Hunters
Schreve, D. & Juby, C., 2008, London: The Illustrated History. Ross, C. & Clark, J. (eds.). London: Allen Lane, p. 22-23 2 p.
The landforms and sedimentology of Caol Lairig (NN 227 786)
Palmer, A. & Tye, G., 2008, The Quaternary of Glen Roy and vicinity: Field Guide. Quaternary Research Association, London., p. 174-184
The Tephrochronology of Roman Lode, Exmoor, Devon.
Matthews, I., 2008, English Heritage. 16 p. (Research Department Report Series; vol. 26)
The Thames Valley
Schreve, D. & Juby, C., 2008, London: The Illustrated History. Ross, C. & John, C. (eds.). London: Allen Lane, p. 20-21 2 p.
Distal volcanic ash layers in the Lateglacial Interstadial (GI-1): problems of stratigraphic discrimination
Pyne-O'Donnell, S. D. F., Blockley, S., Turney, C. S. M. & Lowe, J. J., Jan 2008, In : Quaternary Science Reviews. 27, 1-2, p. 72-84 13 p.
Improved age modelling approaches as exemplified by the revised chronology for the Central European varved lake Soppensee
Blockley, S. P. E., Ramsey, C. B., Lane, C. S. & Lotter, A. F., Jan 2008, In : Quaternary Science Reviews. 27, 1-2, p. 61-71 11 p.
Late Pleistocene loess-palaeosol sequences in the Vojvodina region, north Serbia
Marković, S. B., Bokhorst, M. P., Vandenberghe, J., McCoy, W. B., Oches, E. A., Hambach, U., Gaudenyi, T., Jovanović, M., Zöller, L., Machalett, B. & Stevens, T., Jan 2008, In : Journal of Quaternary Science. 23, 1, p. 73-84 12 p.
Geochemical characterization of Quaternary tephras from the Campanian Province, Italy
Turney, C. S. M., Blockley, S. P. E., Lowe, J. J., Wulf, S., Branch, N. P., Mastrolorenzo, G., Swindle, G., Nathan, R. & Pollard, A. M., Feb 2008, In : Quaternary International. 178, p. 288-305 18 p.
Optical dating of abrupt shifts in the late Pleistocene East Asian monsoon
Stevens, T., Lu, H., Thomas, D. S. G. & Armitage, S. J., May 2008, In : Geology. 36, 5, p. 415-418 4 p.
Reply to the comment on "Some numerical considerations in the geochemical analysis of distal microtephra", by Nicholas J.G. Pearce, Charles A. Bendall and John A. Westgate
Pollard, A. M., Blockley, S. P. E., Lane, C. S. & Blockley, S., May 2008, In : Applied Geochemistry. 23, 5, p. 1365-1366 2 p.
Fluvial Geomorphology: A perspective on current status and methods
Thorndycraft, V., Benito, G. & Gregory, K. J., Jun 2008, In : Geomorphology. 98, p. 2-12
Geomorphological and Palaeohydrological Response of Fluvial Systems to Climatic, Human and Tectonic Controls
Thorndycraft, V., Benito, G. & Gregory, K. J., Jun 2008, In : Geomorphology. 98, p. 1-172 172 p.
Research output: Contribution to journal › Special issue
Reevaluating the Age of the Iberomaurusian in Morocco
Bouzouggar, A., Barton, R. N. E., Blockley, S., Bronk-Ramsey, C., Collcutt, S. N., Gale, R., Higham, T. F. G., Humphrey, L. T., Parfitt, S., Turner, E., Ward, S. & Blockley, S., Jun 2008, In : African Archaeological Review. 25, 1-2, p. 319 17 p.
Palaeohydrology of the Fazzan Basin and surrounding regions: The last 7 million years
Drake, N. A., El-Hawat, A. S., Turner, P., Armitage, S. J., Salem, M. J., White, K. H. & McLaren, S., 23 Jun 2008, In : Palaeogeography, Palaeoclimatology, Palaeoecology. 263, 3-4, p. 131-145 15 p.
Palaeoflood and floodplain records from Spain: Evidence for long-term climate variability and environmental changes
Benito, G., Thorndycraft, V. R., Rico, M., Sánchez-Moya, Y. & Sopeña, A., Oct 2008, In : Geomorphology. 101, 1-2, p. 68-77
Temporal patterns in lacustrine stable isotopes as evidence for climate change during the late glacial in the Southern European Alps
Finsinger, W., Belis, C., Blockley, S. P. E., Eicher, U., Leuenberger, M., Lotter, A. F. & Ammann, B., Oct 2008, In : Journal of Paleolimnology. 40, 3, p. 885-895 11 p.
Paleoenvironmental reconstruction of the Last Glacial Maximum, inferred from insect fossils from a tephra buried soil at Tempest Lake, Seward Peninsula, Alaska
Kuzmina, S., Elias, S., Matheus, P., Storer, J. E. & Sher, A., 1 Oct 2008, In : Palaeogeography, Palaeoclimatology, Palaeoecology. 267, 3-4, p. 245-255 11 p.
Improved age modelling and high-precision age estimates of late Quaternary tephras, for accurate palaeoclimate reconstruction
Blockley, S. P. E., Ramsey, C. B. & Pyle, D. M., 20 Oct 2008, In : Journal of Volcanology and Geothermal Research. 177, 1, p. 251-262 12 p.
Hovk 1 and the Middle and Upper Paleolithic of Armenia: a preliminary framework
Pinhasi, R., Gasparian, B., Wilkinson, K., Bailey, R., Bar-Oz, G., Bruch, A., Chataignerg, C., Hoffmann, D., Hovsepyan, R., Nahapetyan, S., Pike, A. W. G., Schreve, D. & Stephens, M., Nov 2008, In : Journal of Human Evolution. 55, 5, p. 803-816 14 p.
The Middle to Upper Paleolithic transition: dating, stratigraphy, and isochronous markers
Blockley, S. P. E., Ramsey, C. B. & Higham, T. F. G., Nov 2008, In : Journal of Human Evolution. 55, 5, p. 764-771 8 p.
The Bering Land Bridge: a moisture barrier to the dispersal of steppe-tundra biota?
Elias, S. A. & Crocker, B., Dec 2008, In : Quaternary Science Reviews. 27, 27-28, p. 2473-2483 11 p.
Calibration commentary
Blockley, S. P. E. & Housley, R. A., 2009, In : Radiocarbon. 51, 1, p. 287-290 4 p.
Excavations outside Church Hole, Creswell Crags: the first three seasons (2006-8)
Pettitt, P., Jacobi, R. M., Chamberlain, A., Pike, A., Schreve, D., Wall, I., Dinnis, R. & Wragg-Sykes, R., 2009, In : Transactions of the Thoroton Society of Nottinghamshire . 113, p. 35-53 19 p.
Late-glacial remains of woolly mammoth (Mammuthus primigenius) from Shropshire, UK: stratigraphy, sedimentology and geochronology of the Condover site
Scourse, J. D., Coope, G. R., Allen, J. R. M., Lister, A. M., Housley, R. A., Hedges, R. E. M., Williams, R. E. G., Jones, A. S. G. & Watkins, R. M., 2009, In : Geological Journal. 44, 4, p. 392-413 22 p.
Non-destructive sampling of ancient insect DNA
Thomsen, P. F., Elias, S., Gilbert, M. T. P., Haile, J., Munch, K., Kuzmina, S., Froese, D., Sher, A., Holdaway, R. & Willerslev, E., 2009, In : PLoS ONE. 4, 4
Reconstructing Quaternary vegetation history in the Carpathian Basin, SE Europe, using n-alkane biomarkers as molecular fossils: problems and possible solutions, potential and limitations
Zech, M., Buggle, B., Leiber, K., Marković, S. B., Glasser, B., Hambach, U., Huwe, B., Stevens, T., Sümegie, P., Wiesenberg, G. & Zöller, L., 2009, In : Eiszeitalter und Gegenwart: Quaternary Science Journal. 58, 2, p. 148-155
Tephrochronology and wetland archaeology in the British Isles: new developments.
Matthews, I., 2009.
The Last Glacial-Interglacial Transition in South Wales: an integrated investigation of the timing of rapid environmental change.
Palmer, A. P., Matthews, I., Carr, S., Humpage, A. & Lowe, J., 2009, British Geological Survey.
Towards development of a broadly-applicable SAR TT-OSL dating protocol for quartz
Stevens, T., Buylaert, J-P. & Murray, A. S., 2009, In : Radiation Measurements. 44, 5-6, p. 639-645 6 p.
Transitions in the Later Palaeolithic
Housley, R. A., 2009, Sourcebook of Palaeolithic Transitions: Methods, Theories and Interpretations. Camps, M. & Chauhan, P. (eds.). London: Springer-Verlag Press, p. 555-560 6 p.
The loess 'cave' near the village of Surduk – an unusual pseudokarst landform in the loess of Vojvodina, Serbia
Lukić, T., Marković, S. B., Stevens, T., Vasiljević, D. A., Machellett, B., Milojković, N., Basarin, B. & Obreht, I., Feb 2009, In : Acta Carsologica. 38, 2-3, p. 227-235 8 p.
The potential of tephrostratigraphy in the investigation of wetland archaeological records.
Matthews, I., 31 Mar 2009, (Unpublished)
Luminescence and amino acid racemization chronology of the loess–paleosol sequence at Süttő, Hungary
Novothny, Á., Frechen, M., Horváth, E., Bradák, B., Oches, E. A., McCoy, W. B. & Stevens, T., Apr 2009, In : Quaternary International. 198, 1-2, p. 62-76 15 p.
Deflation in the dustiest place on Earth: The Bodélé Depression, Chad
Bristow, C. S., Drake, N. & Armitage, S., 1 Apr 2009, In : Geomorphology. 105, 1-2, p. 50-58 9 p.
Terrestrial and Freshwater carbonates in Hoxnian interglacial deposits, UK: micromorphology, stable isotopic composition and palaeoenvironmental significance
Candy, I., 5 May 2009, In : Proceedings of the Geologists' Association. 120, 1
Optically stimulated luminescence dating as a tool for calculating sedimentation rates in Chinese loess: comparisons with grain-size records
Stevens, T. & Lu, H., Jun 2009, In : Sedimentology. 56, 4, p. 911-934 24 p.
The timing of Quaternary calcrete development in semi-arid south-east Spain: Investigating the role of climate on calcrete genesis
Candy, I. & Black, S., 15 Jun 2009, In : Sedimentary Geology. 218, 1-4, p. 6-15 10 p.
A beetle's eye view of London from the Mesolithic to Late Bronze Age
Elias, S. A., Webster, L. & Amer, M., Sep 2009, In : Geological Journal. 44, 5, p. 537-567 31 p.
Implications of new Quaternary uplift models for correlation between the Middle and Upper Thames terrace sequences, UK
Bridgland, D. R. & Schreve, D. C., Sep 2009, In : Global and Planetary Change. 68, 4, p. 346-356 11 p.
The age and stratigraphic context of the Easington Raised Beach, County Durham, UK.
Davies, B., Bridgland, D., Roberts, D., Cofaigh, C., Pawley, S., Candy, I., Demarchi, B., Penkman, K. & Austin, B., 26 Sep 2009, In : Proceedings of the Geologists' Association. 120, 4
The age and stratigraphic context of the Easington Raised Beach, County Durham, UK
Davies, B. J., Bridgland, D. R., Roberts, D. H., Cofaigh, C. Ó., Pawley, S. M., Candy, I., Demarchi, B., Penkman, K. E. H. & Austin, W. E. N., 28 Sep 2009, In : Proceedings of the Geologists' Association. 120, 4, p. 183-198 16 p.
Differentiation of MIS 9 and MIS 11 in the continental record: vegetational, faunal, aminostratigraphic and sea-level evidence from coastal sites in Essex, UK
Roe, H. M., Coope, G. R., Devoy, R. J. N., Harrison, C. J. O., Penkman, K. E. H., Preece, R. C. & Schreve, D. C., Nov 2009, In : Quaternary Science Reviews. 28, 23-24, p. 2342-2373 32 p.
'The potential for developing an annually-resolved chronology of events in Scotland during the last glacial-interglacial transition (16-8 ka BP)'
Macleod, A., 2010, (Unpublished) 514 p.
Advances in Quaternary Entomology
Elias, S. A., 2010, Elsevier. 307 p. (Developments in Quaternary Sciences; vol. 12)
Assessing the provenance of loess and desert sediments in northern China using U-Pb dating and morphology of detrital zircons
Stevens, T., Palk, C., Carter, A., Lu, H. & Clift, P. D., 2010, In : Geological Society of America Bulletin. 122, 7-8, p. 1331-1344 14 p.
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Are head-mounted displays really going to sell in 2021?
Gartner says there will be more than 67 head-mounted displays (HMDs) sold in 2021. A safer bet is that head-mounted displays will be as cringe-worthy as the mullet or fanny pack.
Written by Larry Dignan, Contributor on Aug. 25, 2017
(Image: Sarah Tew/CNET)
If Gartner projections are correct, we'll be purchasing more head-mounted displays in 2021, but a lot needs to happen between now and then to make that prognostication a reality.
Gartner outlined its wearable device forecast and there weren't a lot of surprises. Smartwatches will be popular, but Bluetooth headsets will move the most units today and into the future.
What jumped out at me was the head-mounted display predictions from Gartner. Head-mounted displays (HMDs) will move 22 million units in 2017 and 67 million in 2021. These head-mounted displays are typically used for augmented reality (think Microsoft HoloLens) or virtual reality (think HTC Vive, Oculus Rift).
CNET: Virtual Reality 101 - Your guide to VR
(Image: Gartner)
Gartner noted that the 67-million-unit guess doesn't represent mainstream adoption:
Near-term opportunities for virtual reality HMDs among consumers are with video game players. Workers will also use them for tasks such as equipment repair, inspections and maintenance, but also in warehouses and manufacturing, training, design, customer interactions and more. Theme parks, theaters, museums and sports venues will purchase HMDs to enhance the customers' experience in interactive attractions or movies, and add information and supplemental images at sporting events.
Now, Gartner was quick to add that HMDs have long-term potential.
Maybe. The jury is out on HMDs. I see people wearing HMDs today, fast forward 20 years, and equate the images to:
That cool mullet you had in the 80s.
That first cell phone that was the size of pickup truck.
Hawaiian shirt Friday.
Skinny jeans worn in any decade.
MC Hammer pants.
Fanny packs.
Big hair, Members Only jackets and pagers.
A few points to ponder:
In the enterprise, HMDs will probably fare well. Why? Workers don't have a choice. Employees will have to wear them for certain tasks and companies will save money on training, remote maintenance, and other functions (notably travel). The key point in the enterprise is that a company can add HMDs to job descriptions fashion, headset weight, and inconvenience be damned.
HMDs are heavy, clunky, and beyond gaming don't have much of a function today. Will that reality change in the future? Somewhat, but not let's get crazy.
People don't like wearing bulky items on their head. Aside from neck issues, it's a hard sell to get me to wear a helmet for much of anything. Headsets today look and feel ridiculous. Sure, you can shrink them down to the point where HMDs are like wearing glasses. But glasses suck, too.
Pricing is a big issue. Yes, HTC cut the price of the Vive. Yes, Facebook's Oculus has a sale and when that end will still be cheaper than the Vive. Sony's PlayStation VR is popular, but will still run you $399. Toss in HMDs from Samsung and others and you can get the price lower, but here's the question: If I gave you an HMD for free would you use it once the novelty wore off? Probably not. If free isn't a good price point you really should wonder about the HMD form factor.
Add it up and it's hard to see Gartner's HMD prediction playing out without a new form factor or some great killer app in the next four years. We've tried the Google Glass thing and it'll only work in the enterprise where there's a captive audience.
A far better bet is that people wearing HMDs today will look back at pictures and cringe.
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Why GE's use of Google Glass marks a turning point for AR
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Google Glass Enterprise Edition gets the company into industry-specific use cases and relies on partners. The approach can work in a nascent field.
AR to be key to business, as VR lands with consumers, says IDC
IDC projected that AR and VR headsets will grow from just under 10 million units in 2016 to nearly 100 million units in 2021.
How virtual reality is improving end-of-life care
In the UK, terminally ill patients are being transported from the hospice to other worlds.
Microsoft's HoloLens: How these surgeons can now voyage around patients' organs
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Five ways augmented reality will transform your business
GoInStore uses AR to blur the line between the online and in-store experience
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Apple's AR/VR headset will reportedly feature unique eye, hand tracking
Samsung Display brings advanced smartphone OLED touch tech to notebooks

redpajama_set_name: RedPajamaCommonCrawl


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Hegeman Family History
Hegeman Name Meaning
Dutch: habitational name for someone from a place called Hegge(n) or ter Hegge(n), derived from a word meaning 'hedge'. Altered spelling of German Hegemann, a Westphalian topographic name for someone who lived in an enclosed (i.e. fenced) area, Middle High German hagen + man 'man'.
Similar surnames: Hageman, Hegemann, Hagemann, Begeman, Hagman, Hegman, Helman, Beeman
Hegeman Family Origin
Where is the Hegeman family from?
You can see how Hegeman families moved over time by selecting different census years. The Hegeman family name was found in the USA, Canada, and Scotland between 1840 and 1920. The most Hegeman families were found in the USA in 1880. In 1840 there were 52 Hegeman families living in New York. This was about 96% of all the recorded Hegeman's in the USA. New York had the highest population of Hegeman families in 1840.
Use census records and voter lists to see where families with the Hegeman surname lived. Within census records, you can often find information like name of household members, ages, birthplaces, residences, and occupations.
View Census Data for Hegeman
Hegeman Family Occupations
What did your Hegeman ancestors do for a living?
In 1880, the most common Hegeman occupation in the USA was Farmer. 28% of Hegeman's were Farmers. Farmer, Keeping House and Carpenter were the top 3 reported jobs worked by Hegeman. A less common occupation for the Hegeman family was Laborer.
View Census data for Hegeman | Data not to scale
Census records can tell you a lot of little known facts about your Hegeman ancestors, such as occupation. Occupation can tell you about your ancestor's social and economic status.
Hegeman Historical Records
What Hegeman family records will you find?
There are 8,000 census records available for the last name Hegeman. Like a window into their day-to-day life, Hegeman census records can tell you where and how your ancestors worked, their level of education, veteran status, and more.
Search 1940's US census records for Hegeman
There are 1,000 immigration records available for the last name Hegeman. Passenger lists are your ticket to knowing when your ancestors arrived in the USA, and how they made the journey - from the ship name to ports of arrival and departure.
View all Hegeman immigration records
There are 1,000 military records available for the last name Hegeman. For the veterans among your Hegeman ancestors, military collections provide insights into where and when they served, and even physical descriptions.
View all Hegeman military records
You've only scratched the surface of Hegeman family history.
Hegeman Life Expectancy
What is the average Hegeman lifespan?
Between 1950 and 2004, in the United States, Hegeman life expectancy was at its lowest point in 1950, and highest in 1979. The average life expectancy for Hegeman in 1950 was 26, and 82 in 2004.
View Social Security Death Index (SSDI) for Hegeman
An unusually short lifespan might indicate that your Hegeman ancestors lived in harsh conditions. A short lifespan might also indicate health problems that were once prevalent in your family. The SSDI is a searchable database of more than 70 million names. You can find birthdates, death dates, addresses and more.
Famous Hegeman Family Ancestors


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Home Life Turkish police detain yet another woman shortly after delivery
topheadline
Turkish police detain yet another woman shortly after delivery
Teacher Ü. Monos, who gave birth on Tuesday, was detained shortly after delivery by police who were waiting outside her room at Ankara Ortadoğu Hospital, the Stockholm Center for Freedom (SCF) reported on Tuesday.
According to Turkish media, Monos is an English teacher and has been sought by police due to her alleged links to the faith-based Gülen movement.
The detention of new mothers has been widely criticized in the media. Main opposition Republican People's Party (CHP) leader Kemal Kılıçdaroğlu slammed the practice of detaining new mothers, calling it "an act of vengeance" during a live show on HaberTürk TV in September. "The state does not act out of vengeance. The state does not act with anger, animosity. If there is evidence, you take it and do what is necessary. I have many examples. A woman gives birth. And her 5-day-old baby is taken away. And she is kept at a police station for three days. We object to this. This is wrong. How can something like this happen? Let's say that woman is guilty. What is the child's crime? Let him, at least, suckle at his mother's breast. That baby needs milk. Believe me, we have highlighted similar incidents many times," Kılıçdaroğlu said."
Another opposition deputy from the CHP, Atila Sertel, pointed to extreme measures taken against families detained due to alleged links to the Gülen movement. Speaking during a live show on the pro-CHP Halk TV, Sertel said he visited Şakran Women's Prison in İzmir and witnessed a series of ongoing violations of fundamental human rights. Sertel said a housewife named Fadime and her teacher husband were arrested and put in different sections of the same prison, while their children were sent to Bitlis province. The couple is accused of involvement in a coup attempt on July 15, 2016. Sertel criticized the Turkish government for arresting hundreds of housewives on coup charges, saying that he does not understand "how a housewife can be seen as a coup perpetrator."
Responding to a parliamentary question from pro-Kurdish Peoples' Democratic Party (HDP) İzmir deputy Müslüm Doğan on Oct. 3, Turkey's Justice Minister Abdulhamit Gül said as of April 2017 a total of 594 children under the age of 6 were being kept in Turkish prisons along with their mothers.
It has become a common occurrence that both parents are taken into custody, leaving no one to care for the children. The Turkish government, on many occasions, has detained pregnant women as well.
Turkey survived a coup attempt on July 15, 2016 that killed 249 people and wounded over a thousand. Immediately after the putsch the Justice and Development Party (AKP) government and President Recep Tayyip Erdoğan pinned the blame on the Gülen movement.
Fethullah Gülen, whose views inspired the movement, strongly denied having any role in the failed coup and called for an international investigation into it, but President Erdoğan — calling the coup attempt "a gift from God" — and the government initiated a widespread purge aimed at cleansing sympathizers of the movement from within state institutions, dehumanizing its popular figures and putting them in custody.
Turkey's Justice Ministry announced on July 13 that 50,510 people have been arrested and 169,013 have been the subject of legal proceedings on coup charges since the failed coup.
detained at hospital with newborn baby
police wait outside hospital
post-coup crackdown in Turkey
woman detained after delivery
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Islamist leader says Erdoğan's party luring opposition mayors with budget allocations
6 pilots among 176 TSK officers facing detention warrants over Gülen links
Turkish justice system fails to release purge victim diagnosed with stage 4 cancer


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RARAF
CMCR
RARAF >
Our Research >
Microfluidics >
Ion Beam and Neutron Core Facility
Microbeam
Flow-and-Shoot Technology (FAST)
Optoelectronic Manipulation
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RARAF Publications
Training and Dissemination
Capillary Electrophoresis with Laser Induced Fluorescence - CE-LIF
We have developed a microbeam-coupled Capillary Electrophoresis system with Laser Induced Fluorescence (CE-LIF). The goal is to allow the simultaneous measurement of multiple reactive oxygen and nitrogen species by staining cells with multiple redox-sensitive dyes. As many of these dyes have very similar emission spectra they cannot be separated using imaging techniques but can be separated by CE-LIF.
What is Capillary Electrophoresis?
CE is a separation technique where analytes migrate through a thin glass capillary under high electric field and separated by their electrophoretic mobility differences.
In CE, there are two superimposed flow modalities experienced by the analytes in the sample plug: (1) Electrophoretic flow, responsible for separating the analytes by charge and mobility. (2) Electroosmotic flow, which drives the buffer and analytes (regardless of polarity) toward the outlet of the capillary and the detector. The electroosmotic flow is driven by the interaction of the electrolytic liquid with the capillary walls leading to the formation of a mobile Debye layer of charges and is much stronger than the electrophoretic flow, ensuring that all analytes will reach the detector.
What is Laser Induced Fluorescence?
Laser Induced Fluorescence is consists of using an intense laser as a light source to excite fluorescent molecules. The light emitted by these molecules (at a different color) can then be easily detected and quantified. By using an intense and focused laser the fluorescent molecules can cycle many times as they cross the laser beam, resulting in a strong signal. Coupled with CE, LIF provides highly sensitive detection, particularly for brightly fluorescent molecules. Using LIF, repeatable detection limits on the order of 70 molecules have been achieved.
What do we want to detect?
Within the first few microseconds following a charged particle traversal of a cell, numerous oxygen and nitrogen radicals are formed along the track. In order to detect these transient species (which are not, themselves fluorescent, they can be used to oxidize various chemicals causing those to become fluorescent
The CE-LIF System at RARAF.
Our CE-LIF system is centered on a 70 cm long fused silica capillary, connecting our cell picker to the LIF detection system. As a detector for the light emitted from the fluorophores, we use a spectrometer, which allows identification of different fluorophores based on subtle differences in their emission spectrum.
NewYork-Presbyterian
ColumbiaDoctors
Center for Radiological Research


The Scranton Muslim Community is a vibrant and inclusive community, reflecting the diversity of cultures and traditions of Muslims from around the world. Its mission is to serve Scranton and surrounding communities with programs in education, arts, culture, and recreation. Inspired by Islamic values and Muslim heritage, the Scranton Muslim Community weaves the Muslim-American identity into the multicultural fabric of the United States. The Scranton Muslim Community aims to foster cooperation and understanding between people of all faiths and backgrounds through relevant programs and initiatives. Our community stands firm against terrorism and religious extremism.
Get directions through Google Maps. The Mosque is located on "1509 West Pass Avenue, Scranton, PA 18508". There are limited number of parking spots next to the Mosque. Parking at the adjacent baseball field can also be used. Please, avoid double parking on the street to avoid inconveniencing the local traffic. Please, do not block driveways under any circumstances!


Cousin is star receiver Antonio Brown; nickname is "Hollywood". Originally attended junior college for one season, then transferred to Oklahoma. Started eight of thirteen games played the following year, leading Oklahoma in receiving with 57-1,095-7, then put together a 75-1,318-10 year before declaring for the draft. Shrimpy Sooners slot receiver, the latest in a long line of impressive prospects from the program; also takes plenty of snaps on the outside, but will be viewed as an inside option at the pro level because of his slight frame. Runs a pretty full complement of routes to different levels of the field, primarily working within ten yards of the line of scrimmage in an Oklahoma offense famous for brilliant play designs aimed at giving their receivers room to run after the catch. Forced some defensive backs to respect his speed and play off, but looks surprisingly effective when it comes to his ability to release at the line, using his suddenness to slip past defenders who crowd him. Does a good job of getting separation and working back to the ball; diet is heavy on hitches, curls, and comebacks. Also crosses over the field and gets a lot of opportunities to gain yards after the catch, navigating through picks; very difficult to stick with as he drags across. Not purely an underneath option; also draws some targets near the sidelines and further down the field. Has enough speed to uncover deep, working in some stutter-steps and changing speeds to freeze high safeties; most likely to be targeted on deep posts instead of down the sidelines. Length constrains his catch radius, but has pretty reliable hands and is capable of bringing in passes away from his frame; did let a couple of passes get slapped out of his hands by defenders during the games reviewed. Dangerous with the ball in his hands, getting upfield quickly and maximizing opportunities to weave through traffic for additional gains; good vision and moves to find lanes and make defenders miss. Works to sustain as a blocker, with arm extension and a willingness to engage; makes the most of his physical attributes. A dynamic receiver in a small, thin frame; does just about everything well and makes the most of his skillset, but will face the typical questions about durability, how he'll release at the line against physical cornerbacks, and whether he has any value as a flanker.


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Becky Lynn Lee is a nobody with big dreams. A devastating act of violence forces her to reach for those dreams . . . but the higher she climbs, the closer the terrible secrets of her past seem to get.
"Packed with glamour and romance, Red is a powerful story about trading love for fame."


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Erin Vito News
March 26, 2018 Erin Vito
Tallgrass Energy Announces Agreement for Tallgrass Energy GP to Acquire Tallgrass Energy Partners; Announces Increased Quarterly Distributions at TEGP and TEP
TEP public unitholders will receive 2.0 TEGP Class A shares for each outstanding TEP common unit; the exchange ratio represents an approximate 10 percent premium to the 30-trading day volume weighted average exchange ratio prior to the company's Feb. 7 acquisitions and restructuring announcements
Proposed transaction will result in no distribution cut to TEP unitholders, and will be accretive to TEGP shareholders and TEP unitholders
TEGP Class A share first quarter 2018 dividend increased to $0.4875, or $1.95 annualized
TEP common unit first quarter 2018 distribution increased to $0.975, or $3.90 annualized
Upon closing the proposed transaction, TEGP will change its name to Tallgrass Energy, LP ("Tallgrass Energy") and will trade on the New York Stock Exchange under the ticker symbol "TGE"
Tallgrass Energy continues to expect Adjusted EBITDA1 of between $755 – $835 million for 2018 and expects dividend coverage for Tallgrass Energy in excess of 1.20x for 2018; dividend growth for existing TEGP shareholders expected to be between 38 – 42 percent for 2018
Upon closing, Tallgrass Energy does not expect to pay cash federal income taxes for a period currently estimated to be at least 10 years
LEAWOOD, Kan.–(BUSINESS WIRE)–Tallgrass Energy GP, LP (NYSE: TEGP) and Tallgrass Energy Partners, LP (NYSE: TEP) today announced the execution of a definitive agreement pursuant to which TEGP will acquire the approximately 47.6 million TEP common units held by the public in a taxable stock-for-unit merger transaction at a ratio of 2.0 TEGP Class A shares for each outstanding TEP common unit.
"We are executing this transaction from a position of fundamental business strength, and the result is a win for the TEP unitholders and TEGP shareholders alike. This non-dilutive combination differentiates our transaction from most other recent combinations in the MLP universe," said President and CEO David G. Dehaemers Jr.
"Eliminating TEP's incentive distribution rights will immediately improve our cost of capital and will enhance our ability to compete for, and the returns generated by, acquisitions and organic growth projects," Dehaemers added. "In addition, our single public entity will be more streamlined, simplified and closely align all of our equity holders' future financial incentives. We expect the combined company, which will be taxed as a corporation, will appeal to an even wider set of potential investors. We are looking forward to closing this transaction and focusing on the next chapter of value creation at Tallgrass Energy."
The merger agreement has been unanimously approved by the Board of Directors of TEGP's general partner, the Conflicts Committee of the Board of Directors of TEP's general partner (the "TEP Conflicts Committee") and the Board of Directors of TEP's general partner. Subject to customary approvals and conditions, the merger is expected to close by the end of the second quarter of 2018.
1Adjusted EBITDA is a non-GAAP financial measure. For additional information, please read "Non-GAAP Measures."
Under the terms of the merger agreement, TEGP will acquire the approximately 47.6 million TEP common units held by the public at a fixed exchange ratio of 2.0 TEGP Class A shares for each outstanding common unit. As a result of the proposed transaction, the TEP incentive distribution rights will be cancelled, the TEP common units will no longer be publicly traded and 100 percent of the equity interests of TEP will be owned by TEGP's subsidiary, Tallgrass Equity, LLC ("Tallgrass Equity").
In the proposed transaction, TEGP will issue an aggregate of approximately 95.2 million Class A shares to former TEP common unitholders, representing approximately 62.1 percent of the outstanding Class A shares of TEGP following the transaction. The revolving credit facilities of TEP and Tallgrass Equity, and the senior notes of TEP are expected to remain outstanding following the merger. Assuming the merger closes on or before the record date for the second quarter 2018 dividend, former TEP unitholders holding TEGP Class A shares on the record date would be entitled to receive the second quarter 2018 dividend on the TEGP Class A shares they receive in the merger in accordance with TEGP's agreement of limited partnership.
Completion of the merger is subject to customary closing conditions, including the approval by holders of a majority of the outstanding TEP common units, including common units owned by Tallgrass Equity, and the expiration or termination of all waiting periods under the Hart-Scott-Rodino Antitrust Improvements Act. As part of the transaction, TEGP and certain of its subsidiaries entered into a support agreement agreeing to vote their approximately 25.6 million TEP common units (representing approximately 35 percent of the total outstanding TEP common units) in favor of the merger.
An investor presentation related to the transaction will be posted on the Tallgrass Energy website. TEP unitholders, TEGP shareholders and other interested parties are invited to view those materials under the investor relations sections at www.tallgrassenergy.com.
TEGP
The board of directors of TEGP's general partner has declared a quarterly cash dividend of $0.4875 per Class A share for the first quarter of 2018, or $1.95 on an annualized basis. This represents a 32.7 percent sequential increase from the fourth quarter 2017 dividend of $0.3675 per Class A share and an increase of 69.6 percent from the first quarter 2017 dividend of $0.2875 per Class A share. It is TEGP's 11th consecutive increase since its May 2015 initial public offering.
The board of directors of TEP's general partner declared a quarterly cash distribution of $0.975 per common unit for the first quarter of 2018, or $3.90 on an annualized basis. This represents a sequential increase of 1.0 percent from the fourth quarter 2017 distribution of $0.965 per common unit and an increase of 16.8 percent from the first quarter 2017 distribution of $0.835 per common unit. It is TEP's 19th consecutive increase since its May 2013 initial public offering.
The TEGP and TEP quarterly distributions for the first quarter of 2018 will be paid on Tuesday, May 15, 2018, to shareholders and unitholders of record as of the close of business on Monday, April 30, 2018.
Barclays acted as advisor to TEGP and Evercore Partners acted as advisor to the TEP Conflicts Committee. Baker Botts L.L.P. served as legal counsel to TEGP and Bracewell LLP served as legal counsel to the TEP Conflicts Committee.
About Tallgrass Energy
Tallgrass Energy is a family of companies that includes publicly traded partnerships Tallgrass Energy Partners, LP (NYSE: TEP) and Tallgrass Energy GP, LP (NYSE: TEGP). Operating across 11 states, Tallgrass is a growth-oriented midstream energy operator with transportation, storage, terminal, water, gathering and processing assets that serve some of the nation's most prolific crude oil and natural gas basins.
To learn more, please visit our website at www.tallgrassenergy.com.
Tallgrass Energy Adjusted EBITDA includes the Adjusted EBITDA for the assets owned by TEP as of Dec. 31, 2017, the additional 2 percent of Tallgrass Pony Express Pipeline, LLC (acquired by TEP effective Feb. 1) and the distributions attributable to the additional 25.01 percent membership interest in Rockies Express Pipeline LLC (acquired by Tallgrass Equity on Feb. 7). Tallgrass Energy Adjusted EBITDA does not include our estimate of approximately $15 – $25 million of shipper deficiency payments that would be included in distributable cash flow. Adjusted EBITDA is a non-GAAP measure.
Adjusted EBITDA is a non-GAAP supplemental financial measure that Tallgrass Energy management and external users of our consolidated financial statements and financial statements of our subsidiaries and unconsolidated investments, such as industry analysts, investors, lenders and rating agencies, may use to assess:
our operating performance as compared to other publicly traded partnerships in the midstream energy industry, without regard to historical cost basis or, in the case of Adjusted EBITDA, financing methods;
the ability of our assets to generate sufficient cash flow to make distributions and dividends to our equity holders;
our ability to incur and service debt and fund capital expenditures; and
the viability of acquisitions and other capital expenditure projects and the returns on investment of various expansion and growth opportunities.
We believe that the presentation of Adjusted EBITDA provides useful information to investors in assessing our financial condition and results of operations. Adjusted EBITDA should not be considered an alternative to net income, operating income, net cash provided by operating activities or any other measure of financial performance or liquidity presented in accordance with GAAP, nor should Adjusted EBITDA be considered an alternative to available cash, operating surplus, distributions of available cash from operating surplus or other definitions in our partnership agreement. Adjusted EBITDA has important limitations as an analytical tool because it excludes some but not all items that affect net income and net cash provided by operating activities. Additionally, because Adjusted EBITDA may be defined differently by other companies in our industry, our definition of Adjusted EBITDA may not be comparable to similarly titled measures of other companies, thereby diminishing their utility.
We generally define Adjusted EBITDA as net income excluding the impact of interest, income taxes, depreciation and amortization, non-cash income or loss related to derivative instruments, non-cash long-term compensation expense, impairment losses, gains or losses on asset or business disposals or acquisitions, gains or losses on the repurchase, redemption or early retirement of debt, and earnings from unconsolidated investments, but including the impact of distributions from unconsolidated investments.
Tallgrass Energy is unable to project net cash provided by operating activities or net income attributable to partners to provide the related reconciliation of projected Adjusted EBITDA to the most comparable financial measures calculated in accordance with GAAP, because the impact of changes in operating assets and liabilities and the volume and timing of deficiency payments received and utilized from our customers are out of our control and cannot be reasonably predicted. Tallgrass Energy provides a range for the forecasts of Adjusted EBITDA to allow for the variability in the timing of cash receipts and disbursements, customer utilization of our assets, and maintenance capital spending and the impact on the related reconciling items, many of which interplay with each other. The timing of maintenance capital expenditures is volatile as it depends on weather, regulatory approvals, contractor availability, system performance and various other items. Therefore, the reconciliation of projected Adjusted EBITDA to projected net cash provided by operating activities and net income attributable to partners is not available without unreasonable effort.
Additional Information and Where to Find it
In connection with the transactions referred to in this material, TEGP expects to file a registration statement on Form S-4 with the Securities and Exchange Commission ("SEC") that will include a proxy statement/prospectus for the TEP unitholders. After the registration statement is declared effective, TEP will mail a definitive proxy statement/prospectus to its unitholders. This material is not a substitute for the joint proxy statement/prospectus or registration statement or for any other document that TEGP or TEP may file with the SEC and send to TEGP's and/or TEP's shareholders or unitholders in connection with the proposed transactions.
INVESTORS AND SECURITY HOLDERS OF TEGP AND TEP ARE URGED TO READ THE PROXY STATEMENT/PROSPECTUS AND OTHER DOCUMENTS FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION.
This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities or a solicitation of any vote or approval.
Investors and security holders will be able to obtain free copies of the proxy statement/prospectus (when available) and other documents filed with the SEC by TEGP or TEP through the website maintained by the SEC at http://www.sec.gov. Copies of the documents filed with the SEC by TEGP and TEP will be available free of charge on TEGP's and TEP's website at www.tallgrassenergylp.com, in the "Investor Relations" tab near the top of the page, or by contacting TEGP's and TEP's Investor Relations Department at 913-928-6012.
TEGP and TEP and their respective general partner's directors and executive officers may be considered participants in the solicitation of proxies with respect to the proposed transactions under the rules of the SEC. Information about the directors and executive officers of TEGP's general partner may be found in its 2017 Form 10-K filed with the SEC on Feb. 13, 2018, and any subsequent statements of changes in beneficial ownership filed with the SEC. Information about the directors and executive officers of TEP may be found in its 2017 Form 10-K filed with the SEC on Feb. 13, 2018, and any subsequent statements of changes in beneficial ownership filed with the SEC. These documents can be obtained free of charge from the sources indicated above. Additional information regarding the participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, will also be included in any proxy statement and other relevant materials to be filed with the SEC when they become available.
Cautionary Note Concerning Forward-Looking Statements
Disclosures in this press release contain forward-looking statements. All statements, other than statements of historical facts, included in this press release that address activities, events or developments that management expects, believes or anticipates will or may occur in the future are forward-looking statements. Without limiting the generality of the foregoing, forward-looking statements contained in this press release specifically include the expected consideration to be received in connection with the closing of the merger transaction, whether the merger transaction between TEP and TEGP will be consummated before the end of the second quarter of 2018 or at all, whether the proposed transaction will be accretive to TEGP shareholders and TEP unitholders, the Tallgrass Energy financial guidance for 2018, that Tallgrass Energy upon closing will not pay cash federal income taxes for a period estimated to be at least 10 years, whether the elimination of TEP's incentive distribution rights will improve TEP's and TEGP's cost of capital or enhance TEP's and TEGP's ability to compete for, or increase returns generated by, acquisitions or organic growth projects, and whether the structure resulting from the merger will be more appealing to a wider set of investors. Such statements are subject to a number of assumptions, risks and uncertainties, many of which are beyond the control of TEP and TEGP, which may cause actual results to differ materially from those implied or expressed by the forward-looking statements, and other important factors that could cause actual results to differ materially from those projected, including those set forth in reports filed by TEP and TEGP with the SEC. Any forward-looking statement applies only as of the date on which such statement is made and TEP and TEGP do not intend to correct or update any forward-looking statement, whether as a result of new information, future events or otherwise, except as required by law.
Tallgrass Energy
Investor and Financial Inquiries
Nate Lien, 913-928-6012
investor.relations@tallgrassenergylp.com
Media and Trade Inquiries
Phyllis Hammond, 303-763-3568
phyllis.hammond@tallgrassenergylp.com
Chief Industries, Inc. and Catahoula Resources Announce Agreement to Advance Carbon Capture and Sequestration in Nebraska
Cheniere Announces Collaboration with Natural Gas Suppliers and Academic Institutions to Quantify, Monitor, Report and Verify GHG Emissions
Battelle and Catahoula Resources Forge Partnership to Accelerate Carbon Capture, Utilization and Storage
2229 San Felipe Street, Suite 1300
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Who does He proclaim good news to? Not the rich. Not the famous. Not the Who's-Who. He brings this good exciting news to the desperate, the needy–the poor.
He takes the brokenhearted and binds up their wounds. He pronounces freedom to those held captive. He releases prisoners trapped in darkness.
He turns mourning and grieving into comfort and joy.
He makes a crown of beauty out of ashes.
He takes a spirit clothed in despair and replaces it with a lovely wardrobe of praise.
We serve a God who doesn't just build-He rebuilds. He doesn't just store-He restores. He doesn't just make and use new things-He renews all things. He renews ruined things, devastated things, things that have been devastated for generations.
Our God loves to use messy people. The Bible is full of messed up people who God used in powerful ways. If you think the Bible is all about perfect people, you are reading the wrong Bible.
I am so so thankful for that. We tend to think of Christians as "goodie goodies." We put them on pedestals. We think that they have it all together. Neat, nice, put together people. It's not true. Christians are all just sinners saved by grace.
Here are a few examples in the Bible of some messed up people God chose to use in powerful ways. God used Moses-a murderer. God used Jacob-a manipulator. God used David-an adulterer and murder. God used Paul-He murdered Christians before he got saved. God put the prostitute Rahab in Jesus' birth linage. The list goes on and on.
God doesn't call it like it is. He calls it like it could be. He calls us like how He knows we could be.
If we surrender our lives to Him, yes, all of our lives–our brokenness, our messiness, our sin, If we give it all to Him, He will come into our lives and rebuild, restore, and renew.
Then He will call us oaks of righteousness—a planting of the Lord—a display of His splendor.
Now that is some really good news!
Check out this wonderful song if you have a chance!
Don't you just love this verse?!?! It's like it builds and builds…bigger…stronger…louder, until it's shouting God's power! Such an encouragement! In world so broken God is still in control, He still has a plan, and He WILL accomplish His purposes. AMEN!!!


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Home » Archive by Category
Articles in FEATURE STORY
Garage 56 Le Mans Effort To Feature All-Star Lineup
Saturday, 28 Jan, 2023 – 13:30 | Comments Off on Garage 56 Le Mans Effort To Feature All-Star Lineup
By John Sturbin | Senior Writer
A diverse and experienced driver lineup featuring former 24 Hours of Le Mans winner Mike "Rocky" Rockenfeller will pilot NASCAR's Garage 56 entry during the 100th anniversary edition of the …
Sunday, 15 Jan, 2023 – 12:58 | Comments Off on Seavey Collects His First Chili Bowl Championship
By John Sturbin/Senior Writer
Californian Logan Seavey joined the ranks of dirt track racing royalty Saturday night, holding off reigning event champion Tanner Thorson to win the 37th annual Lucas Oil Chili Bowl Nationals in Tulsa, …
Saturday, 14 Jan, 2023 – 9:36 | Comments Off on Cup Champ Larson Headed To Indy 500 In 2024
NASCAR superstar Kyle Larson will double his Memorial Day weekend workload in May 2024, when he joins Arrow McLaren for the 108th running of the Indianapolis 500.
Larson's Chevrolet-powered Dallara will …
Friday, 13 Jan, 2023 – 8:51 | Comments Off on For Harvick, The 'Right Moment' Has Arrived
It will be Happy Trails for "Happy" Harvick at the end of the 2023 NASCAR Cup Series season.
The 2014 Cup Series champion, Harvick announced Thursday in Kannapolis, N.C., that his …
Thursday, 12 Jan, 2023 – 9:03 | Comments Off on Oklahoma's Davis Stands Tall At Chili Bowl Nationals
Oklahoman Hank Davis proved the underdog still has a shot at victory in the 37th annual Chili Bowl Nationals, fending off Spencer Bayston for his first career preliminary night win.
Andretti and GM's Cadillac Eyeing Entry Into Formula One
Thursday, 5 Jan, 2023 – 15:34 | Comments Off on Andretti and GM's Cadillac Eyeing Entry Into Formula One
Andretti Global and General Motors _ American powerhouses in the automotive and motorsports sectors _ have announced their intention to pursue an opportunity to compete in the FIA Formula One …
Dakar Rally Rocks On In Saudi Arabia
Tuesday, 3 Jan, 2023 – 9:04 | Comments Off on Dakar Rally Rocks On In Saudi Arabia
Nasser Al-Attiyah, Daniel Sanders and Mitch Guthrie excelled over Stage Two's dangerous boulders during the 45th edition of the Dakar Rally in Saudi Arabia.
Jan. 2/Stage 2/Sea Camp-Aluha/Distance-Total/Special: 589.07-kilometers/430- kilometers
_ Over …
Storylines Begin To Emerge At The Dakar Rally
Monday, 2 Jan, 2023 – 17:39 | Comments Off on Storylines Begin To Emerge At The Dakar Rally
Carlos Sainz, Kevin Benavides and Chaleco López were the early headliners during Sunday's tricky Stage One of the 45th edition of the Dakar Rally, motorsport's toughest test of endurance.
Jan. 1/Stage …
Off-Roaders Set To Take On The Desert In Annual Dakar Event
Friday, 30 Dec, 2022 – 9:33 | Comments Off on Off-Roaders Set To Take On The Desert In Annual Dakar Event
Starting field for the annual Dakar Rally has assembled in Saudi Arabia for the event's 2023 edition beginning on Saturday, Dec. 31, with the world's best off-road racers facing 5,000-plus …
Top '22 Pro Stock Rookie Caruso Joins KB Racing
Thursday, 22 Dec, 2022 – 9:53 | Comments Off on Top '22 Pro Stock Rookie Caruso Joins KB Racing
KB Titan Racing has added reigning NHRA Rookie of the Year Camrie Caruso to a 2023 Pro Stock lineup led by five-time world champion Greg Anderson.
KB Titan Racing is the …
Racin' Today – Quote from John Force
"I'm excited to see writers like Jim Pedley, John Sturbin, Rick Minter, and Bill Fleischman, guys who have written about me, working together at www.racintoday.com. The internet is huge and it is giving talented guys like these professionals a place to get their stories out to our fans and the public. The media is changing and I am excited to see writers that have covered me and all of motorsports creating a new way to get our stories to our fans. They can take motorsports journalism to the next level. I've dealt with these guys for over 15 years all across the country."
"As an example of the character of these guys, when Sturbin was with the Ft. Worth Star Telegram and I was racing at the Texas Motorplex, one of my favorite tracks he showed how he is an individual who gets it. He understands the sport and the drivers. Years ago I ran my mouth at the Texas Motorplex saying I was going to go out and set a record and if I didn't I would eat his newspaper column. Well I didn't set the record so I went into the press room and ate his column the next day. He told before I started that I didn't have to follow through but I told him if I say something I am going to back it up whether I win or lose. That is the kind of pro Sturbin is as well as the rest of the writers at racintoday.com are. They will write the truth whether you like it or not."
"You better not blame something on your car because Sturbin will dig and find out whether or not it was the car or you. He gets down in the trenches, tells the truth, and he knows what he is talking about. I am excited for these writers and this new website because I have always loved the media and I know that without the media you don't have much. You have to be able to tell your story and get it right. These guys are guys who will make sure they get it right." - JOHN FORCE
Follow John Force Racing at www.twitter.com/jfr_racing


The façades of Chinatown are vibrant with patina and bursting with stories about the generations of family-run medicinal halls and teahouses that continue to thrive amid a new crop of boutique hotels and cocktail bars.
Singapore is a city of juxtapositions—a compact island nation where breathtaking architectural wonders exist alongside colonial-era structures and the steamy bustle of the city streets are a microclimate away from the cool verdant hills above.
Revel in the dichotomy of the modern and historic, the gritty and polished, the earth's bounty and man's creations. Take time to wander the side streets and back alleys, where you'll come across sumptuous courtyards, historic homes with intricate details, and shops that continue to operate as they did decades ago.
Don't forget to look up when wandering around the Joo Chiat neighborhood, where heritage shophouses with vibrant colors and elaborate tile work represent an eclectic mix of Chinese, Malay, and European influences.
Kampong Glam (named for the gelam tree native to the area), originally a predominantly Muslim community, is now a lively neighborhood where old school street vendors display their wares alongside newly established boutiques.
Masjid Sultan, in the heart of Kampong Glam, mixes traditional Hindu and Islamic details with Gothic and Neo-classical design elements. The surrounding area comes alive during Ramadan, when the fast is broken after sundown and night markets buzz with festive energy.
Many of the best gems are tucked away upstairs instead of on street-level. I wandered up a narrow stairwell and into a lovely conversation with the owner of oh!eaf, a ceramic studio with an extremely high temperature kiln in a Chinese village that has been creating pottery for over 1,700 years.
SaladShop, a contemplative two-story showroom off busy Haji Lane, showcases understated home goods along with refine fashion pieces.
The "black and whites," as they are affectionately called on the island, blend traditional English styles with tropical aesthetics, an architectural nod to Singapore's colonial history.
A dusk cocktail at Coriander Leaf Grill is the ideal way to kick off an evening on the town, barhopping along Ann Siang Road's sophisticated bistros.
Simply wandering down side alleys in some of the older enclaves, such as the Katong District, is an adventure in itself.
The blooming bougainvilleas frame the many condominiums on the island, where limited real estate equates to plenty of vertical living.
Books Actually, in the burgeoning Tiong Bahru neighborhood, highlights local authors and homegrown indie mags. Pick up some solid reads for café hopping in the area or, as I did, for my long flight back across the Pacific Ocean.
Singapore is incredibly green on every corner, every view, every alleyway. The vibrant tropical fauna thrives in the humid climate that comes from its proximity to the equator.
Mount Faber Park, with its dense vegetation and cool air, is the perfect respite from a sweaty afternoon wandering around town. It is the highest peak in Singapore, with sweeping city views of the central business district and Sentosa Island.


Turns out you don't have to be in Venice, California to try to get your hand on Spectacles.
Snap's video-camera product has already hit eBay. The bidding for a black pair reached $553 as of 12 p.m. Thursday, after an hour on the website. That's already a 325 percent markup from the retail price of $130.
A coral pair was going for $175.
Snap unveiled its grand distribution strategy for Spectacles Thursday. The product will be sold via interactive vending machines placed in locations throughout the United States, for one day only.
The first machine landed in Snap's Venice at about 6 a.m. local time. It's down the block from Snapchat's first official office, which was a bright blue beach house in the neighborhood.
Snap isn't saying yet where the next ones are coming, but will announce locations on its website, Spectacles.com, 24 hours ahead of time.


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Q: Ошибка TemplateDoesNotExist at /blog/, как решить? Код Viеws
from django.shortcuts import render, get_object_or_404
from django.core.paginator import Paginator, EmptyPage, PageNotAnInteger

from .models import *

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def post_detail(request, year, month, day, post):
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        published__month = month, published__day = day)
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Код templates/blog/base.html
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Код templates/post/list.html
{% extends "blog/base.html" %}
{% block title %}My Blog{% endblock %}
{% block content %}

My Blog

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A: Скорее всего вы не указали папку с шаблонами, вы не показали файл settings.py, но проверьте, что у вас имеется путь до папки в переменной TEMPLATES файла settings.py.
Путь до неё должен быть указан в значении ключа DIRS.
TEMPLATES = [
    {
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        'DIRS': [os.path.join(BASE_DIR, "templates")],
        ...
    }
]

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text:
Controversy regarding the functional conservation of cereblon CUL4-type E3 ligase substrate receptor
Afua A Akuffo
Department of Immunology, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Cancer Biology Ph.D. Program, University of South Florida, Tampa, FL, USA
Aileen Y Alontaga
Harshani R Lawrence
Chemical Biology Core, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Department of Oncologic Sciences, University of South, Tampa, FL, USA
Nicholas J. Lawrence
Department of Drug Discovery, Moffitt Cancer Center and Research Institute, Tampa, FL, USA
Pearlie K Epling-Burnette
DOI: 10.15761/ICST.1000283
Thalidomide, first developed in Germany in 1956, is infamously known for its teratogenic properties when used for hyperemesis gravidarum and sedation [1]. From the late 1950s until 1962, use of this drug rapidly expanded to 48 countries where it was responsible for birth defects ranging from congenital heart disease, malformations in limb development and ocular abnormalities in thousands of children. While initial preclinical data suggested that thalidomide had an acceptable safety profile in rodents, testing in pregnant animals was not a mandated practice at the time [2]. The tragedy of thalidomide-rapidly led to significant changes in the processes required for medical product development throughout the world with enactment of an amendment to the United States Federal Food, Drug and Cosmetic Act in 1962 requiring more rigorous preclinical testing for new pharmaceuticals [3].
In the early 2000s, thalidomide was repurposed in the clinic as a potent antiangiogenic [4] and immunomodulatory compound [5] for the treatment of multiple myeloma (MM), myelodysplastic syndrome harboring a chromosomal deletion in 5q [del (5q) MDS] and other hematological malignancies [6,7]. The drug was approved for cancer treatment under an FDA directive requiring routine pregnancy testing with distribution of written and verbal warnings to inform patients of the detrimental impact of thalidomide on fetal development [8]. Many studies have confirmed the relationship between thalidomide, and its related class of compounds (also known as immunomodulatory drugs, IMiD®) and teratogenicity in humans, zebrafish, chickens and in rodents when given during specific periods of gestation [1,9-12]
Fifty years after the thalidomide tragedy, Takumi Ito and colleagues revealed the molecular mechanism of this drug through elegant studies conducted in zebrafish and chickens [12]. Cereblon (CRBN) was identified as the direct target of immunomodulatory compounds and one of many DDB1 and CUL4-associated factors (DCAFs) that directs protein turnover by ubiquitination and subsequent proteasome recognition. Cereblon acts as a substrate recruiting module for the DDB1–CUL4A–Roc1–RBX1 E3 ubiquitin ligase complex [12,13] and the immunomodulatory compounds thalidomide, lenalidomide, pomalidomide, and avadomide (Figure 1) alter its recruiting functions by attracting various "neo" protein substrates including Ikaros, Aiolos, [14] and casein kinase 1α (CK1α) [15] to the DDB1-CUL4A-Rbx1 complex (Figure 2). It is now well established that immunomodulatory drug-dependent degradation of Ikaros and Aiolos potentiates human T cells [16] and is responsible for the cytotoxicity of human MM cells [17]. CK1α degradation is selectively targeted by lenalidomide which garners an apoptotic phenotype that is uniquely associated with clinical responses in del(5q) MDS [18].
Figure 1. Structure of thalidomide and related immunomodulatory drug class.
Figure 2. Model of immunomodulatory-drug mechanism of activation by binding Cereblon (CRBN).
Despite advances in our understanding of immunomodulatory drugs and their molecular mechanism, the notion that mice and other rodents are "resistant" to immunomodulatory compounds has been widely circulated due to the initial erroneous safety reports. In the thalidomide binding domain (TBD) of CRBN, examination of the sequences across vertebrate species revealed that CRBN is structurally well-conserved except for three amino acids (Cys366 human to Ser369 mouse, Glu377 to Val380 mouse, and Val388 human to Ile391 mouse) [19]. Interestingly, Ile391 is also present in chicken CRBN and in all non-mammal vertebrates excluding the flying lemur. Structural studies have now demonstrated how immunomodulatory drugs form a molecular bridge between CRBN and its drug-dependent binding partner CK1α [15]. Interestingly, Ile391 introduces a steric hindrance that diminishes the binding of all known neo-substrates that contain a conserved β-hairpin loop in their secondary structure including CK1α, Ikaros and Aiolos [15]. Explicitly, in the lenalidomide-CRBN-CK1α interaction, additional Van der Waals forces are formed at Val388, which stabilizes the complex and enhances the ubiquitin degradation of the substrates [15].
Consistent with the current premise on the role of Ile391, we confirmed that Ikaros ubiquitin-mediated degradation fails to occur in mouse T cells and multiple myeloma tumor cells [19]. We also demonstrated functional resistance of mouse T cells with regard to interleukin-2 production and proliferation. Mouse multiple myeloma cell lines showed no evidence of apoptosis in response to immunomodulatory drug treatment in comparison to potent suppression of several human multiple myeloma cell lines. CRBN protein expression levels were similar in most of the mouse and human cell lines tested which is consistent with the possibility that mouse cells are inherently resistant to immunomodulatory drugs and thus fundamentally different with regard to CRBN function. This is also consistent with the idea that Ikaros/CK1α recruitment is indeed responsible for T cell potentiation [15,19] and responsible for the cytotoxic effects of these drugs in human tumor cells [15,19].
Consequently, the negative impact of Ile391 in response to immunomodulatory drugs raises crucial questions about the physiological performance of CRBN in rodents and in other vertebrates possessing this amino acid variant. If non-drug-induced CRBN substrates (i.e., native substrates) contain a similar β-hairpin conserved structure present in CK1α, Ikaros and Aiolos, then Val388 may represent a functionally inactive variant selected through evolutionary adaptation in mammals. Using theoretical modeling studies and orthogonal drug binding assays to several CRBN TBD sequence variants, we demonstrated that the Ile391 CRBN TBD protein does not alter its binding affinity with immunomodulatory drugs [19] suggesting that this variant may retain at least some of the physiological properties.
Given the conserved immunomodulatory drug binding properties, we then hypothesized that target recruitment may be selectively compromised by Ile391 or other variants of CRBN. Since all known immunomodulatory drug-induced neo-substrate recruitment occurs through an interaction with a conserved β-hairpin-loop structure, we exploited a new technology called proteolysis targeting chimeras (PROTAC) to replace the substrate binding capacity of CRBN [20]. This new technology was first developed more than a decade ago as a means of selectively recognizing intracellular proteins and triggering their destruction for scientific and therapeutic applications. These compounds contain complementary bifunctional components that 1) interact with specific proteins, and 2) engage an E3 ligase to trigger the proteasome-mediated degradation of specified proteins of interest. Thalidomide–related compounds are key components of PROTAC technology due their fidelity in hijacking the CRBN/DDB1/Cul4A/Rbx1 E3 ubiquitin ligase complex (20). Using dBET1, a thalidomide-JQ1 PROTAC, that degrades BET domain proteins [21], we investigated the E3-ubiquitin ligase function of mouse CRBN. Interestingly, we demonstrated that mouse CRBN can bind thalidomide containing PROTACs with similar binding affinity, trigger CRBN-dependent degradation of BRD4, and thus confirmed that the CRBN/DDB1/Cul4A/Rbx1 complex is functional in mouse cells.
It is cogent to postulate that there is a resistance mechanism related to the V388I mutation and reduction in Ikaros, Aiolos, and CK1α degradation. However, chicken CRBN, and other vertebrate species, also exhibit this mutation, but show sensitivity to thalidomide. CRBN-dependent developmental defects after thalidomide treatment have been definitively shown in several Ile391-containing species [12]. Therefore, it is possible that teratogenicity, and perhaps other effects of immunomodulatory drugs, occur through a distinct mechanism. CRBN interacts intracellularly with calcium-activated potassium channels and the metabolic sensor adenosine monophosphate-activated protein kinase (AMPK), which in the latter, suppresses its activation and its downstream target mammalian target of rapamycin (mTOR) [22-24]. Collectively, this data suggests that there may be multiple endogenous substrates of CRBN and that the immunomodulatory drugs may influence its physiological function through different mechanisms. One study in particular proposes a ubiquitin-independent role for CRBN as a chaperon for the plasma membrane glycoprotein, CD147, and the monocarboxylate transporter, MCT1, that transports lactate [25]. In this study, researchers showed that the CD147-MCT1 complex is vital for the regulation of cellular metabolism and expression of fibroblast growth factor 8, which is the transcription factor reported to mediate thalidomide-associated teratogenicity in zebrafish and chickens [12]. Furthermore, through elegantly designed experiments, these investigators showed that thalidomide treatment destabilizes the CD147-MCT1 complex and that a morpholino-induced loss of CD147 suppresses limb development similar to thalidomide. Collectively, this study suggests that destabilization of the CD147-MCT1 complex is responsible for immunomodulatory drug-induced teratogenicity rather than degradation of the established neo-substrates [25].
Few medical disasters have reached the level of thalidomide-associated teratogenicity and had such prevailing consequences in its aftermath. Elucidation of thalidomide's molecular target has been widely applauded as a major scientific breakthrough. Insights into aspects of CRBN biology relevant for the preclinical development of PROTAC compounds in humans are likely to continue for decades. However, we highlight the potential disadvantages of using CRBN-targeting PROTAC compounds as they all may harbor teratogenic potential, but should be tested in rodents and other relevant animal models during pre-clinical development. Using these new agents, it may be possible to appreciate the physiological roles for CRBN in protein regulation since it is evident that it plays a fundamental role in both proteasome and non-proteasome-related cellular regulation as well as in fetal development.
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Hiroshi Miyamoto
University of Rochester Medical Center
Received date: July 28, 2018
Accepted date: August 18, 2018
Published date: August 22, 2018
© 2018 Akuffo AA. This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited.
Akuffo AA, Alontaga AY, Lawrence HR, Lawrence NJ, Epling-Burnette PK (2018) Controversy regarding the functional conservation of cereblon CUL4-type E3 ligase substrate receptor. Integr Cancer Sci Therap. 5: DOI: 10.15761/ICST.1000283
PK Epling-Burnette
Immunology Department, Moffitt Cancer Center, Tampa, FL 33543, USA.


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