Do you plan to become a real estate agent in Canada?
If you are a Canadian resident and you feel like you are up for the challenges of this profession, you might be surprised to know that it is not really as hard as many people believe. There is an extensive array of career paths licensed realtors can choose from in the country, which means that many doors of opportunity are very much wide open for you. These opportunities include residential, industrial, investment and commercial properties and becoming a property management specialist. Also, there is farming realty and realty business brokering.
License holders should be at least 18 years of age in order to become a realtor.
Canadian residents who have a high school diploma or an equivalent educational attainment can qualify.
Any realtor who wants to get licensed in Ontario or other provinces in Canada should be fluent in English. Knowing a second language is also a plus.
Take note that depending on the province where you live, the requirements for licensing can differ. It would be your responsibility to check on the different course requirements to be a licensed realtor.
You have to complete are require courses, a good example of which is the Real Estate Associate's Program.
Send applications to express your interest to work with brokers.
See to it that your background check has been completed.
Identify the path where you would like your career as a realtor to go to. Would you like to become a property manager? Does your goal include working with investment properties? Now would be the perfect time for you to nail down this decision.
Take the 15-day course for licensing. Your score must be a minimum of 70% for you to get a passing grade.
Finalize the Application for a Salesperson and the Schedule A for your broker to provide the signatures on the forms. The forms, together with the letter which state that you completed and passed the examination, need to be sent to Nova Scotia Real Estate Commission together with the copy of your birth certificate, driver's license and all the associated fees.
Digital marketing is a term that has been around for quite awhile but hasn't been very well defined, encompassing things like poster advertising, search engine optimization (SEO) and pay per click. Yet, this is too narrow of a meaning. What about email, RSS, voice broadcast, fax broadcast, blogging, podcasting, video streams, wireless text messaging, and immediate messaging? You get the idea.
To clearly define what digital marketing is let's converse about what it is not. For starter, it does not include more traditional forms of marketing such as radio, TV, billboard and print because they do not present instant feedback and report. Sure, some people may respond to a call to deed from an advertisement in one of these mediums but there is no way to know the exact number of people who saw or heard it. Such facts are collected (and still then just educated guesses) long after the initial ad idea is made. Yes, convergence has made TV a bit more interactive, with devices such as TiVo-able to record watcher figures like those for Web sites, but there is still a long way to go. With digital marketing, however, we're already there.
By its heart, digital marketing centers around the Internet, which has become both a communication vehicle and an extremely powerful marketing medium as the recent Doubleclick acquisition by Google demonstrated. The Internet can be used either to push a message to someone like email, IM, RSS, or voice broadcast, as well to pull content serving a poster ad and Pay per Click search terms. Digital advertising, therefore, can be thought of as the combination of push and pull Internet technologies to execute advertising campaigns.
Because it is digital, a reporting engine can be layered within a campaign allowing the association see in real-time how that campaign is performing, such as what is being viewed, how frequently, how long, as well as other actions such as responses rates and purchases made. Please note that each digital advertising technology is different and they cannot all give the same types of reports. Also, digital marketing is continually evolving and new technologies are individually created all of the time.
Broadband Internet, WiFi, and phone Web access are also spurring increase worldwide. A current report showed that Web usage increased 10% from last January to this January universal. Not astonishingly, billions of marketing dollars spent on traditional channels is already starting to move to digital advertising campaigns and this will carry on increasing as the Web matures. As a marketer, I am extremely eager about the future and what digital marketing will seem like in the years ahead. I mean, we immediately got to Web 2.0 consequently who knows what will be coming then? If you haven't already started, you need to build a database of clients or potential clients and find out how they wish to be reached. You can do this through the digital advertising technologies I've mentioned in this article and then use these systems to advertise your products and services.


text:
The Branch Manager Switch
There was a time, not too long ago, when for many a tenured financial advisor, graduating to a branch-manager position was the ultimate aspiration. It was seen as an honor, a natural progression in a successful career. After all, branch office managers spent most of their time guiding, inspiring and overseeing other advisors basically, taking care of the troops. For many advisors, that aspiration
Mindy Diamond | May 01, 2008
There was a time, not too long ago, when for many a tenured financial advisor, graduating to a branch-manager position was the ultimate aspiration. It was seen as an honor, a natural progression in a successful career. After all, branch office managers spent most of their time guiding, inspiring and overseeing other advisors — basically, taking care of the troops.
For many advisors, that aspiration remains the same. But the job has changed. In today's hyper-vigilant compliance environment, many branch managers — whether at small independent b/ds or giant Wall Street wirehouses — find themselves acting as paper pushers and traffic cops. Fulfilling firms' and regulators' demanding compliance requirements has taken a front seat, as has meeting aggressive revenue growth and recruiting targets.
Many branch managers are finding it difficult to balance all of these demands. "There was a time where I spent maybe 15 minutes a day on compliance-related issues," says Brad, a West Coast wirehouse branch manager. "Fast forward a few years, and now I am spending many hours on a daily basis making sure that my office is compliant. Even though my office has had only two customer complaints in the last four-and-a-half years (both of which were settled for nominal amounts), I really feel bogged down and unable to focus as much time as I would like on helping my brokers build their businesses."
For some branch managers, especially those without their own books of business, the most striking problem is the lack of job security. This is the case even for very successful and long-tenured branch managers. Take Vince, a large-city manager in a high-visibility branch for one of the major firms, who was recently terminated for "failure to supervise." Vince had been a producer for many years before he gave up his book and went into the firm's management program. He quickly moved up the ladder to manage more and more prestigious offices. Vince was an outstanding recruiter, bringing in hundreds of millions of dollars in new assets a year, and hiring some of the top producers in his market.
Despite his outstanding performance, he was fired over a single non-compliant broker who signed off on a trade without obtaining client approval. Vince no longer has a book of business, his compliance record is marred and the market is flooded with non-producing management candidates, many of whom have clean compliance records and were earning less than Vince did.
In today's turbulent markets, it might seem like a relief to give up a book of business and graduate to management. Take Scott, an advisor who has worked at three firms during his 15-year career, and produces annual revenue of $700,000 on $80 million in assets. Feeling "burnt out" by the current market, he was considering becoming a branch manager. Scott, who is 42 and works in a Midwest wirehouse branch, said he wanted more intellectual stimulation, and believed he would enjoy mentoring other advisors.
He was aware of certain drawbacks. For one thing, non-producing branch- management positions for small branches don't pay a lot, with salaries in the $75,000 to $125,000 range plus incentive compensation — in total much less than what he was earning as a financial advisor. But it was the prospect of spending long hours early in the morning and late in the evening to meet with potential recruits — so that he could meet aggressive recruiting goals — that ultimately turned him off. (He has two young kids.)
That said, there are some appealing opportunities out there. In the race for top talent, some firms are offering producing management positions in smaller offices to exceptional advisor recruits — without the hassles of compliance or recruiting work. In these arrangements, the firms expect an advisor to bring over his book of business, while compliance and recruiting work are handled at the district level. If you've always dreamed of being a branch manager, this kind of arrangement might be a perfect fit.
Writer's BIO: Mindy Diamond
founded Chester, N.J.-based Diamond Consultants, which specializes in retail brokerage and banking recruiting.
www.diamondrecruiter.com
TAGS: Archive Practice Management

redpajama_set_name: RedPajamaCommonCrawl


text:
Is BBQ a Texas thing?
June 29, 2022 by Tad Guzman
Many regions of the United States claim to offer the best barbecue in the country. Kansas City, North Carolina, and Memphis all proudly boast of their BBQ prowess. But for many connoisseurs of brisket, sausage, and pork ribs, there is one state that rises above all others: Texas.
1. Did BBQ come from Texas?
2. Why is Texas famous for BBQ?
3. What is Texas BBQ?
4. How is Texas Barbeque different?
4.1. Related Videos
4.2. Related Articles
Did BBQ come from Texas?
It wasn't until the early 1800s when the word barbecue—a variation of the Haitian word barbacot, meaning a framework of sticks for smoking or roasting meat—was likely used for the first time in Texas.
What country invented BBQ?
But barbecues the way that Americans know them now meat cooked over a grill or pit, covered in spices and basting sauce originated in the Caribbean. The word barbecue comes from the language of a Caribbean Indian tribe called the Taino.
Who started BBQ in America?
"Around the turn of the 18th century, Spanish and British colonists were cooking meat barbecue-style along the coast," Moss says. "Some of the earliest mentions of barbecue came from New England." From there, it spread to Virginia, where it evolved to become one of the primary forms of social entertainment.
What are the origins of BBQ?
The American BBQ tradition owes its origins to the fusion of many cultural food traditions, including African and Caribbean. At its earliest origins, barbecue involved slow-cooking meat over sticks and saplings, a common activity among indigenous Americans and Caribbeans.
Why is Texas known for brisket?
During the late 1800s, many Ashkenazi Jews, as well as Czechs and Germans, emigrated to Texas. These immigrants brought with them their cuisine, which included brisket.
Why is Texas famous for BBQ?
Central Texas barbecue is credited to Czech and German settlers who owned butcher shops and would often smoke leftover meat to preserve it. They began offering smoked meat to customers, and it was so popular they eventually evolved into barbecue joints.
What is the barbecue capital of the world?
Since the early 1900s, the words "Kansas City" and "barbecue" have been synonymous. Today, barbecue still stands as the city's signature cuisine. So much so, that it attracts people from all over the world who just have to see and taste it for themselves.
Who is the number 1 BBQ in Texas?
Texas Monthly has released its list of the best barbecue joints in the Lone Star State, and a Fort Worth restaurant claimed the No. 1 spot. Goldee's Barbecue in southeast Fort Worth (nearly Kennedale) was ranked best in the state.
Which Texas City has best BBQ?
Best known for music and barbecue, Austin is a can't-miss on the barbecue trail. From fine-dining to truck stop, every smoker adds their own spin and style to the traditional sweet and tangy tomato-based sauce.
What is Texas BBQ?
Texas barbecue, also called Texas BBQ, seasoned smoked meats—specifically beef brisket, pork ribs, and sausage—associated with Texas. Texas barbecue has a number of influences, including the meat-smoking techniques of 19th-century immigrants from Germany and Czechoslovakia who settled in the central part of the state.
What's the difference between Kansas City and Texas BBQ?
The primary difference here is that this meat is cooked for an even longer period of time in order to produce exceptionally tender meat. It's also cooked over hickory wood and uses a wet marinade rather than a dry rub.
How is Texas Barbeque different?
West Texas barbecue, sometimes called "cowboy style," traditionally uses a more direct heating method than other styles. Food is generally cooked over mesquite, granting it a distinct, smoky flavor that is different from other wood-smoked styles.
'Texas Eats' Episode 5: Central Texas BBQ
I Learned REAL Texas BBQ
LEGENDARY TEXAS BBQ | FOUR HOURS Wait! Snow's BBQ
Can you put stainless steel on Blackstone griddle?
Who is Melissa Cookston married to?
Tad Guzman
Tad Guzman is America's #1 authority on grilling. He has written five books on the subject, including the best-selling "Grilling for Dummies." He has appeared on countless TV shows, including the Food Network's "Good Eats" and the PBS series "Barbecue University." He is a member of the American Academy of Culinary Arts and the Barbecue Hall of Fame.
How do you oil a Chef camp griddle?


Standing strong at 19-7, and 2-0 in Sun Belt play, the Bobcats softball team has been taking care of their fundamentals in the past several games. Going 2-0 against Georgia State, including a 5-4, 10-inning boxing match, was another display of grit. Beating Incarnate Word and Baylor were slow, controlled climbs in which the Bobcats battled in their own style for seven innings. Moving into the second Sun Belt series against 14-10 Coastal Carolina will demand the same, clean style of play to continue riding a wave of consistency.
The Coastal Carolina Chanticleers are a team who began the season with six of their 10 games ending in complete blowouts. Since late February, however, the Chanticleers have been subject to teams who can blow up the scoreboard with equal power. A 5-8 record since February 23rd is not a total death knell; the true sign of concern is the way they have been decimated in the losses.
Despite those losses, the Chanticleers only separation point between powering over teams and mediocrity is the mental aspect in finishing individual moments. Collectively, they possess a .850 team OPS behind a slugging percentage (SLG) of .479 and an on-base percentage of .367 (OBS). Now, the higher SLG is a question mark, as that analytical line is typical with teams who have great runs and equally abrasive slides (as displayed in their young season).
When the run gets going for the Chanticleers, they are a deadly versatile cast of talent. Seven batters currently hold an OPS of .850 or greater. Courtney Dean and Kassidy Smith lead the team with a 1.260 and 1.07 OPS respectively. Dean has only struck out three times, walked once, hit five home runs, and landed 21 other hits in 50 at-bats. Suffice to say, that is incredible. Smith is the more balanced batter with 16 hits in 53 at-bats, but she also walks 36 percent of the time (19) while striking out 25 percent (13).
The entire team follows a methodology akin to Dean – for example, bench hitter Mackenzie Budinger has yet to walk with only seven hits in 28 at-bats. However, she has added an additional three home runs. Alexis Alvino is also bringing power with numbers eerily reminiscent to Budinger, just doubled. Alvino's five home runs have been paired with nine walks, but 19 strikeouts.
The note to be taken away on the Chanticleers lineup is they will clean up on mistakes. If a pitcher does not approach each batter uniquely, they will pick up on patterns and punish teams accordingly. Their battle with pitchers is an enticing chess match taken down to the tuning of each individual pitch.
The Chanticleers pitching has been on the back of Ashley Guilette (8-4), Kaitlin Beasley-Polko (6-6), and reliever Taylor Schmidt (only 10 innings). Guilette and Beasley-Polko are juxtaposed in what they prevent and allow. Guilette has walked 52 batters, has five complete games, but allowed nine less hits and 10 less runs; hence, she will lose plate-control quicker, but is analytically more efficient with pitch breadth. Beasley-Polko pitches more to the zone, walking only 31 batters and striking out seven more (77) than Guilette. She has also allowed 61 hits, 39 runs, and given up nine doubles and a triple, implicating that batters will pierce her pitching to the strike zone. No matter, they have 74.1 to 73 innings pitched respectively, and in their own right, will be formidable when allowed to control the flow from the precept.
The Bobcats softball team has been taking care of their fundamentals in the past several games. Photo by Nicole Wolf.
Leaving off on the last note, the Chanticleers are a team who must be tested in inning one, less they fine-tune confidence. The Bobcats have typically struggled early in games and had to battle their way back. This is a series that must be epitomized by battling pitch-to-pitch with defensive and offensive prowess.
Fortunately, the Bobcats lineup has been developing a balanced approach, functionally getting on base. The team is riding behind the austerity of Hailey MacKay's 30 hits, 14 walks, and six homeruns, equating to a team leading OPS of 1.192. Ariel Ortiz and Bailee Carter have followed up with .891 and .972 OPS respectively. Both, however, are not only embellished by the temptation of power hits, rather consistency. Ortiz has 11 walks to seven strikeouts and Carter has 10 walks to five strikeouts.
Christina McDowell and Ortiz both add unique traits to the team that have further aided the overall perspective. Ortiz has been cleaning up for batters once they get on base with three homeruns, 23 RBIs, five doubles, and a triple. She is that unique character that can frustrate pitchers, taking them far into a count. McDowell is the batter who will get on base and then create chaos. No batter has owned their specialty more than McDowell. Her average OPS of .718 hides what athleticism can do; her single double and triple have been created due to that quickness, and she has yet to be caught stealing, now with eight.
The batting lineup can puncture the Chanticleer's pitching if the early lineup continues to string together hits and the latter half can get on base once they turn back to lead-off. This weekend's test will be about who can control and mentally own each pitch.
Randi Rupp has been the pitcher to do just that, and more. Although she has now reached 113.1 innings of pitching, she is holding a 1.67 ERA, striking out 139 batters, and walking only 21. Watching Rupp is an incredible science in planning and controlling the narrative of opposing batters. If there is one pitcher who can play chess against the Coastal Carolina power-hitters, it will be Rupp.
The biggest test of McKenna Fryar's freshman career thus far will be against Coastal Carolina. She has tentatively been balanced against veteran batters, allowing only minimal scoring. By contrast, this will be the first power-hitting team that Fryar will face, leaving little room for error. She has allowed only two homeruns thus far with seven runs in 34 innings pitched. The question is once she processes the lineup once or twice, how much variety in pitch type she can scare the Chanticleers with.


Since book 1 in the Whiskeys series I have been dying to read Wayne "Bones" Whiskeys story. Admittedly I wasn't sure how I was going to like the fact that Sarah was pregnant with two other kids being his love interest, but her past and her story with Bones was told in true Melissa style. She took a sensitive subject of the physical and emotional abuse that Sarah had gone through and told it in my eyes, with tact in a respectful way.
This is one rollercoaster read full of emotion, love and everything in between. Sarah is a strong woman, though she's doesn't fully realise it and when Bones shows how caring, respectful and supportive he is, she finally let's him in and boy what a story they create.
Wicked whiskey love had me crying and whilst it is an emotional heart-breaking read it is also heart warming at the same time.
This is right up there with Tru Blue sharing the top spot of my fave Melissa Foster book's!


Do Holidays Give Us a Window into the Soul of Society?
MTW has posted video recordings of all the main session sermons from the MTW Global Missions Conference (including Ravi Zacharias) Grab a snack and your notebook – these are great messages!
Jesus Christ is Risen! Did you wake up and remind yourself of that marvelous truth today? It is a great truth that has both daily and eternal consequences for us as believers. And we are graphically reminded of our sure and certain hope of eternal life whenever we attend a funeral or pass a graveyard….
Easter: A Date on a Calendar or a Day that Changes Everything?


text:
FOREIGN CORNER
"The Future of Antitrust: A Global Perspective" Webinar
We Believe In Fair Play
On 10 December 2020, Prica & Partners' partner Darija Ognjenović participated in an international webinar dedicated to antitrust issues.
The webinar was organized by JURIS and panel discussion on the future of antitrust was moderated by Brattle Director of Global Development James Keyte. The discussion covered the current state of global antitrust and what lies ahead in the near and distant futures.
Key topics:
Areas of divergence/convergence among U.S./EU and rest of world jurisdictions
Specific developments (case law and regulation) addressing the digital economy, including nascent acquisitions, emerging theories of dominance/abuse
The interplay among antitrust, Big Data, consumer protection and privacy
The panelists included: Olivier Guersent, Director General of the Directorate General for Competition; William E. Kovacic, Global Competition Professor of Law and Policy at George Washington University Law School and Director of the University's Competition Law Center; Eleanor M. Fox, Walter J. Derenberg Professor of Trade Regulation at New York University School of Law; Barry Hawk, Former Director of the Fordham Competition Law Institute and Former Partner with Skadden Arps
Darija Ognjenović
Montenegro desk
office@pricapartners.com
+381 11 2621-741,
3031-885, 2625-970
Kneza Miloša 23/IV
11000 Belgrade, Serbia
Keep up-to-date with the latest news and legislative changes.
TERMS & CONDITIONS | WEBSITE PRIVACY POLICY
Copyright 2018 - Prica & Partners


text:
Predicting Landing Spots for Top 10 Available MLB Offseason Targets
Danny KnoblerMLB Lead WriterJanuary 3, 2017
Tom Szczerbowski/Getty Images
No player enters free agency hoping to sign in January. No team wants to let half the winter go by with significant needs unfilled.
But here we are in the new year. Free agents remain unsigned. Deals that had to be made remain undone.
And Jose Bautista wonders where it all went wrong. Or maybe he doesn't.
If Edwin Encarnacion waited forever before landing with the Cleveland Indians on a three-year, $60 million deal, Bautista has waited forever and two weeks to find his next employer. The Minnesota Twins have waited forever to get a Brian Dozier trade done. The New York Mets still have too many outfielders, and the Atlanta Braves still haven't improved behind the plate.
Oh, and after trading Chris Sale and Adam Eaton in two much-praised deals, the Chicago White Sox have gone nearly a month without more rebuilding.
There's plenty still to do as we wait for Hall of Fame voting results and the start of spring training.
Reporting day is just six weeks away. Now these guys just need to know where to report.
We're here to help, with Bleacher Report's predictions for where the top remaining winter targets will land.
10. Todd Frazier
Jonathan Daniel/Getty Images
The Chicago White Sox have big-ticket items available on their shelf, and Nick Cafardo of the Boston Globe wrote Saturday first baseman Jose Abreu has been the target of more interest than Todd Frazier. That's understandable because a team could control Abreu for three years, while Frazier will be a free agent next winter.
The years of control, though, make for little urgency in moving Abreu, unless the White Sox get offers like the ones that convinced them to trade Chris Sale and Adam Eaton last month. There's less to be gained by holding on to Frazier, who turns 31 just before spring training begins.
Frazier overcame a slow start to hit 40 home runs in his one year in the American League, but it's easier to see a National League team picking him up in hopes he returns to the form that made him a two-time All-Star with the Cincinnati Reds. The San Francisco Giants, who could use a bat and some help at third base, seem like a logical fit.
It can't hurt that Frazier is a career .358 hitter at AT&T Park.
Prediction: The White Sox trade Frazier to the Giants.
9. Jay Bruce
Christopher Pasatieri/Getty Images
It shouldn't be that tough to trade a three-time All-Star who can carry a team when he gets hot. But it seemed to take the Cincinnati Reds forever to move Jay Bruce before they dealt him to the New York Mets on Aug. 1, and now the Mets have gone more than a month since they re-signed Yoenis Cespedes without reducing their glut of corner outfielders.
Bruce didn't end up being a great fit in New York, and he became even less of one when the Mets said Cespedes will play left field. With three other corner outfielders (Curtis Granderson and Michael Conforto in addition to Bruce), a trade seemed inevitable.
It still does, and Bruce remains the most logical one to go. Granderson can play center field if needed, and Conforto offers too much hope for the future.
The Mets have no doubt been hurt by the number of corner outfield types on the free-agent market. Many of them remain available, but teams looking for bargains could see Bruce at $13 million as a good deal. He'll be motivated as he heads to free agency next winter.
So where does he go? It's just a guess because no team has been publicly connected to Bruce, but the Tampa Bay Rays make some sense. Marc Topkin of the Tampa Bay Times reported last month they might be open to a discounted one-year deal with Jose Bautista. He lives in the area, but it's unlikely his price would ever get low enough for the small-budget Rays.
Bruce's $13 million is a lot as well, but perhaps the Mets will agree to pay some of it down.
Prediction: The Mets trade Bruce to the Rays.
8. Matt Wieters
When the Baltimore Orioles signed Welington Castillo to be their new catcher, it seemed clear Matt Wieters would move on after eight years that didn't match the hype but did result in four All-Star appearances and two trips to the playoffs.
According to Dan Connolly of Baltimore Baseball.com, agent Scott Boras told reporters three weeks ago he didn't expect Wieters to sign until January because the catching market often develops late. If so, maybe Wieters' market will get better this month.
Per Jon Heyman of FanRag Sports, the Washington Nationals have long been connected to Wieters—a natural fit given their need for catching and history with Boras clients. So have the Atlanta Braves, who are another natural fit given their even more desperate need for catching and that Wieters played at Georgia Tech.
The Nationals already acquired Derek Norris this winter. Wieters would be an upgrade, but they may not want to spend big to get him. The Braves have the bigger need, with unimpressive holdovers Tyler Flowers and Anthony Recker as their two catchers.
Prediction: Wieters signs with the Braves.
7. Ryan Braun
Justin Berl/Getty Images
Ryan Braun would be higher on this list if not for a contract that runs through 2020, when he'll be 36. The contract also limits the number of teams the Milwaukee Brewers can trade Braun to without his approval.
A deal with the Los Angeles Dodgers has always seemed a fit given their financial resources and Braun's Southern California roots. But a Brewers-Dodgers trade that Fox Sports' Ken Rosthenal reported was discussed last summer never happened, and speculation it could be rekindled this winter hasn't yet led to much.
It figures the Brewers will still try, with the Dodgers or anyone else. As important as Braun has been to the club, their best hope to speed up the rebuilding process would be to trade him for younger talent. But it won't be easy.
Prediction: Braun stays with the Brewers—at least for now.
6. Mike Napoli
It's hard to blame the Cleveland Indians for choosing Edwin Encarnacion once his price fell into their range. But they understood Mike Napoli's value, as most of his former employers have.
The Texas Rangers are one of those former employers, and Napoli nearly won them their first World Series by driving in 10 runs against the St. Louis Cardinals in 2011. It's hardly a surprise the Rangers have shown interest in bringing him back, with MLB.com's T.R. Sullivan reporting last week the sides were "moving closer" to a two-year deal.
Texas needs offensive help after Carlos Beltran, Ian Desmond and Mitch Moreland all left as free agents.
Prediction: Napoli signs with the Rangers.
5. Andrew McCutchen
Justin K. Aller/Getty Images
After the Washington Nationals traded for Adam Eaton instead of Andrew McCutchen, Pittsburgh Pirates general manager Neal Huntington said it was unlikely he'd trade McCutchen this winter, per MLB.com's Adam Berry.
A trade was probably unlikely in the first place, and it may still be unlikely now. But the reasons Huntington had for exploring a deal remain valid. McCutchen is heading into his final two years of team control, and the budget-conscious Pirates are unlikely to extend a player who will be 32 at the end of his contract.
Pittsburgh isn't giving up on contending in 2017, so McCutchen still has value to it. But as the free-agent market for outfielders becomes clearer, perhaps Huntington will find an offer to his liking. The Toronto Blue Jays could be a natural trading partner, especially if Jose Bautista ends up elsewhere. ESPN.com's Jerry Crasnick tweeted Christmas Eve that the Jays had "kicked around" McCutchen's name.
Prediction: The Pirates trade McCutchen to the Blue Jays.
4. Brian Dozier
Jim McIsaac/Getty Images
There's no trade deadline in the winter, which is one reason some of these sagas drag on and on. The Minnesota Twins apparently want to create some urgency in the Brian Dozier market, with La Velle E. Neal III of the Star Tribune reporting Friday they've asked teams for their best offer.
Neal wrote the Twins are prepared to keep Dozier if they don't like any of the offers, and perhaps they will. But he's two years from free agency, which means this could be the best time to trade him, and he's one player who could bring back the young pitching Minnesota needs.
The Los Angeles Dodgers have long been mentioned as a good trade partner for the Twins because they need a second baseman and right-handed power and have young pitching to offer. Neal noted Minnesota has asked for pitcher Jose De Leon and another prospect.
Prediction: The Twins trade Dozier to the Dodgers.
3. Jose Quintana
Jon Durr/Getty Images
Once the Chicago White Sox committed to rebuilding, Chris Sale was always going to be the big prize. But Jose Quintana isn't a bad second choice, especially in a winter in which the free-agent market for starting pitchers is so weak.
The White Sox can keep Quintana, whose contract includes club options through 2020. The deal shouldn't limit the market, either, because Quintana makes only $6 million in 2017 and just $10.5 million in each of the two option years.
Quintana is a harder sell than Sale as a staff ace, but he would be a significant front-end upgrade for many teams. The New York Yankees have been mentioned frequently, including by MLB.com's Jon Morosi, and ESPN's Buster Olney tweeted the Pittsburgh Pirates have worked hard on a possible Quintana deal. Jake Kaplan of the Houston Chronicle reported during the winter meetings that the Houston Astros asked about Quintana but found the initial asking price too high.
That's normal in negotiations, and it still would make sense for the Astros and White Sox to come together. Houston has plenty of young talent, and while it's upgraded offensively with Carlos Beltran, Josh Reddick and Brian McCann, the rotation still isn't imposing.
Prediction: The White Sox trade Quintana to the Astros.
2. Mark Trumbo
Mark Trumbo and the Baltimore Orioles ended up being a near-perfect fit in 2016 after the club got him in a bargain deal with the Seattle Mariners. He won't be as big a bargain this time around, even with a market that has developed so slowly that he's still available.
On Wednesday, Jon Heyman of FanRag Sports listed Trumbo as the best slugger still available. I have him second, but either way, he has big value. Heyman suggested Trumbo could still return to the Orioles, even after he turned down a four-year offer.
While I could see that happening, I like the idea of Trumbo going to the Colorado Rockies to play first base, with Ian Desmond moving to his more natural spot in the outfield. Rockies general manager Jeff Bridich said on MLB Network Radio two weeks ago that Trumbo remains on their radar.
You would think Colorado would be on Trumbo's radar, too. In just 12 career games at Coors Field, he has hit eight home runs.
Prediction: The Rockies sign Trumbo.
1. Jose Bautista
When the idea of the Baltimore Orioles signing Jose Bautista came up, Orioles executive vice president of baseball operations Dan Duquette dismissed it.
"Jose is a villain in Baltimore, and I'm not going to go tell our fans that we're courting Jose Bautista for the Orioles because they're not going to be happy," Duquette told Eduardo A. Encina of the Baltimore Sun.
Bautista is a villain in a lot of places, but he's also a free agent who hasn't found the market he would like and could be a late bargain for the team that signs him. Duquette has a history of finding such deals, and his Orioles will need a boost from somewhere if Mark Trumbo signs with another team.
If they don't find that boost, then their fans really wouldn't be happy.
Bautista could still end up going back to the Toronto Blue Jays, but Jon Heyman of FanRag Sports penned a few reasons why he thinks that's unlikely. Marc Topkin of the Tampa Bay Times reported the Tampa Bay Rays could be open to a one-year deal with Bautista, but only at a bargain price.
At this point, Bautista's deal should look like a bargain for whichever team signs him, but perhaps that won't be enough of a bargain to interest the Jays or Rays. It may be enough of a bargain, however, for Orioles fans to welcome a villain.
Prediction: The Orioles sign Bautista.


В обзоре литературы представлен анализ методов диагностики нейродегенеративных изменений проводящих путей зрительного анализатора при первичной открытоугольной глаукоме. У большинства больных с длительным течением заболевания даже на фоне нормализованного внутриглазного давления происходит прогрессивное ухудшение зрительных функций. По последним данным, глаукоматозное повреждение не ограничивается ганглионарными клетками сетчатки, а распространяется на весь зрительный путь: сетчатку, зрительный нерв, зрительный перекрест, зрительные тракты, латеральные коленчатые тела, зрительную лучистость и кору головного мозга. В статье представлены результаты обследования больных первичной открытоугольной глаукомой с помощью стандартной магнитно-резонансной томографи и, функциональной магнитно-резонансной томографии и диффузионной тензорной визуализации. Также представлены результаты морфологических методов исследования, которые подтверждают дегенеративные изменения, выявленные с помощью неинвазивных методов. В последние годы все чаще встречаются работы, в которых первичная открытоугольная глаукома рассматривается как нейродегенеративное заболевание наряду с таким заболеванием, как болезнь Альцгеймера. В данном обзоре приведены факты, объединяющие эти заболевания. Полное понимание ретробульбарного и интракраниального глаукоматозного повреждения может позволить проводить наиболее эффективную диагностику первичной открытоугольной глаукомы и способствовать открытию новых терапевтических стратегий для защиты зрительного нерва.
1. Menzler K., Belke M., Wehrmann E., Krakow K., Lengler U., Jansen A. Men and women are different: diffusion tensor imaging reveals sexual dimorphism in the microstructure of the thalamus, corpus callosum and cingulum. Neuroimage 2011; 54:2557-2562. doi.org/10.1016/j.neuroimage.2010.11.029.
2. Quigley H.A., Broman A.T. The number of people with glaucoma worldwide in 2010 and 2020. Br J Ophthalmol 2006; 90:262-267. doi.org/10.1136/bjo.2005.081224.
3. Nucci C., Martucci A., Cesareo M., Mancino R., Russo R., Bagetta J. et al. Brain involvement in glaucoma: advanced neuroimaging for understanding and monitoring a new target for therapy. Curr Opin Pharmacol 2013; 13:128-133. doi.org/10.1016/j.coph.2012.08.004.
4. Engin K.N., Yemisci B., Bayramoglu S.T., Güner N.T., Özyurt O., Karahan E. et al. Structural and functional evaluation of glaucomatous neurodegeneration from eye to visual cortex using 1.5T MR Imaging: a pilot study. J Clin Exp Ophthalmol 2014; 5:341. doi.org/10.4172/2155-9570.1000341.
5. Weinreb R.N. Glaucoma neuroprotection: What is it? Why is it needed? Can J Ophthalmol 2007; 42:396-398. doi.org/10.3129/can.j.ophthalmol.i07-045.
6. Quigley H.A. Neuronal death in glaucoma. Prog Retin Eye Res 1999; 18:39-57. doi.org/10.1016/s1350-9462(98)00014-7.
8. Rao S.M., Binder J.R., Hammeke T.A., Bandettini P.A., Bobholz J.A., Frost J.A. et al. Somatotopic mapping of the human primary motor cortex with functional magnetic resonance imaging. Neurology 1995; 45:919-924. doi.org/10.1212/wnl.45.5.919.
9. Duncan R.O., Sample P.A., Weinreb R.N., Bowd C., Zangwill L.M. Retinotopic organization of primary visual cortex in glaucoma: comparing fMRI measurements of cortical function with visual field loss. Prog Retin Eye Res 2007; 26:38-56. doi.org/10.1016/j.preteyeres.2006.10.001.
10. Frezzotti P., Giorgio A., Motolese I., De Leucio A., Iester M., Motolese E. et al. Structural and functional brain changes beyond visual system in patients with advanced glaucoma. PLoS ONE 2014; 9(8): e105931. doi.org/10.1371/journal.pone.0105931.
11. Schneider K.A., Richter M.C., Kastner S. Retinotopic organization and functional subdivisions of the human lateral geniculate nucleus: a high-resolution functional magnetic resonance imaging study. J Neurosci 2004; 24:8975-8985. doi.org/10.1523/jneurosci.2413-04.2004.
12. Lestak J., Tintera J., Svata Z., Ettler L., Rozsival P. Glaucoma and CNS. Comparison of fMRI results in high tension and normal tension glaucoma. Biomed Pap Med Fac Univ Palacky Olomouc Czech Repub 2014; 158(1):144-153. doi.org/10.5507/bp.2013.038.
13. Williams A.L., Lackey J., Wizov S.S., Chia T.M., Gatla S., Moster M.L. et al. Evidence for widespread structural brain changes in glaucoma: a preliminary voxel-based MRI study. Invest Ophthalmol Vis Sci 2013: 5880-5887. doi.org/10.1167/iovs.13-11776.
14. Dai H., Mu K.T., Qi J.P., Wang C.Y., Zhu W.Z., Xia L.M. et al. Assessment of lateral geniculate nucleus atrophy with 3T MR imaging and correlation with clinical stage of glaucoma. Am J Neuroradiol 2011; 32:1347-1353. doi.org/10.3174/ajnr.a2486.
15. Lee J.Y., Jeong H.J., Lee J.H., Kim Y.J., Kim E.Y., Kim Y.Y. et al. An investigation of lateral geniculate nucleus volume in patients with primary open-angle glaucoma using 7 tesla magnetic resonance imaging. Invest Ophthalmol Vis Sci 2014; 55(6):3468-3476. doi.org/10.1167/iovs.14-13902.
16. Iba-Zizen M.T., Istoc A., Cabanis E.A. The results of MRI exploration of glaucoma patients: what are the benefits? Fr Ophtalmol 2008; 6:24-28.
18. Ciccarelli O., Catani M., Johansen-Berg H., Clark C., Thompson A. Diffusion-based tractography in neurological disorders: concepts, applications, and future developments. Lancet Neurol 2008; 7:715727. doi.org/10.1016/s1474-4422(08)70163-7.
19. Basser P.J., Pierpaoli C. Microstructural and physiological features of tissues elucidated by quantitative diffusion tensor MRI. J Magn Reson B 1996; 111:209-219. doi.org/10.1016/j.jmr.2011.09.022.
20. Pierpaoli C., Jezzard P., Basser P.J., Blarnett A., Di Chiro G. Diffusion tensor MR imaging of the human brain. Radiology 1996; 201:637-648. doi.org/10.1148/radiology.201.3.8939209.
21. Filippi M., Cercignani M., Inglese M., Horsfield M.A., Comi G. Diffusion tensor magnetic resonance imaging in multiple sclerosis. Neurology 2001; 56:304-311. doi.org/10.1212/wnl.56.3.304.
22. LeBihan D. Looking into the functional architecture of the brain with diffusion MRI. Nat Rev Neurosci 2003; 4:469-480. doi.org/10.1016/j.ics.2006.04.006.
23. Hui E.S., Fu Q.L., So K.F., Wu E.X. Diffusion tensor MR study of optic nerve degeneration in glaucoma. Conf Proc IEEE Eng Med Biol Soc 2007:4312-4315. doi.org/10.1109/iembs.2007.4353290.
24. Garaci F.G., Bolacchi F., Cerulli A., Melis M., Spano A., Cedrone C. et al. Optic nerve and optic radiation neurodegeneration in patients with glaucoma: in vivo analysis with 3-T diffusion-tensor MR imaging. Radiology 2009; 252:496-501. doi.org/10.1148/radiol.2522081240.
25. Li K., Lu C., Huang Y., Yuan L., Zeng D., Wu K. Alteration of fractional anisotropy and mean diffusivity in glaucoma: novel results of a meta-analysis of diffusion tensor imaging studies. PLoS ONE 2014; 9(5): e97445. doi.org/10.1371/journal.pone.0097445.
26. Anjari M., Srinivasan L., Allsop J.M., Hajnal J.V., Rutherford M.A., Edwards A.D. et al. Diffusion tensor imaging with tract-based spatial statistics reveals local white matter abnormalities in preterm infants. Neuroimage 2007; 35:1021-1027. doi.org/10.1016/j.neuroimage.2007.01.035.
27. Bolacchi F., Garaci F.G., Martucci A., Meschini A., Fornari M., Marziali S. et al. Differences between proximal versus distal intraorbital optic nerve diffusion tensor magnetic resonance imaging properties in glaucoma patients. Invest Ophthalmol Vis Sci 2012; 53:4191-4196. doi.org/10.1167/iovs.11-9345.
28. Zhang Y.Q., Li J., Xu L., Zhang L., Wang Z.C., Yang H. et al. Anterior visual pathway assessment by magnetic resonance imaging in normal-pressure glaucoma. Acta Ophthalmologica 2012; 90:295-302. doi.org/10.1111/j.1755-3768.2011.02346.x.
29. Gupta N., Ang L.C., Noel de Tilly L., Bidaisee L., Yucel Y.H. Human glaucoma and neural degeneration in intracranial optic nerve, lateral geniculate nucleus, and visual cortex. Br J Ophthalmol 2006; 90:674-678. doi.org/10.1136/bjo.2005.086769.
30. Engelhorn T., Haider S., Michelson G., Doerfler A. A new semiquantitative approach for analysing 3T diffusion tensor imaging of optic fibres and its clinical evaluation in glaucoma. Acad Radiol 2010; 17:1313-1316. doi.org/10.1016/j.acra.2010.04.017.
31. Engelhorn T., Michelson G., Waerntges S., Otto M., El-Rafei A., Struffert T. et al. Changes of radial diffusivity and fractional anisotopy in the optic nerve and optic radiation of glaucoma patients. Scientific World J 2012; 1-5. doi.org/10.1100/2012/849632.
32. Zikou A.K., Kitsos G., Tzarouchi L.C., Astrakas L., Alexiou G.A. et al. Voxel-based morphometry and diffusion tensor imaging of the optic pathway in primary open-angle glaucoma: a preliminary study. AJNR Am J Neuroradiol 2012; 33:128-134. doi.org/10.3174/ajnr.a2714.
33. Wu S., Chen K. An efficient key-management scheme for hierarchical access control in e-medicine system. J Med Syst 2012; 36:23252337. doi.org/10.1007/s10916-011-9700-7.
34. Yucel Y.H., Zhang Q., Weinreb R.N., Kaufman P.L., Gupta N. Atrophy of relay neurons in magno- and parvocellular layers in the lateral geniculate nucleus in experimental glaucoma. Invest Ophthalmol Vis Sci 2001;42: 3216-3220.
35. Алексеев В.Н., Газизова И.Р. Нейродегенеративные изменения у больных первичной открытоугольной глаукомой. Практическая медицина 2012; 4:154-156.
36. Crawford M.L., Harwerth R.S., Smith E.L., Shen F, Carter-Daw-son L. Glaucoma in primates: cytochrome oxidase reactivity in parvo- and magnocellular pathways. Invest Ophthal Vis Sci 2000; 41(7):1791-1802.
37. McKinnon S.J., Schlamp C.L., Nickells R.W. Mouse models of retinal ganglion cell death and glaucoma. Exp Eye Res 2009; 88(4):816-24. doi: 10.1016/j.exer.2008.12.002.
38. Wang W.H., McNatt L.G., Pang I.H., Hellberg P.E., Fingert J.H., McCartney M.D. et al. Increased expression of serum amyloid A in glaucoma and its effect on intraocular pressure. Invest Ophthalmol Vis Sci 2008; 5:1916-1923. doi.org/10.1167/iovs.07-1104.
39. Goldblum D., Kipfer-Kauer A., Sarra G.M., Wolf S., Frueh B.E. Distribution of amyloid precursor protein and amyloid-beta immunoreactivity in DBA/2J glaucomatous mouse retinas. Invest Ophthalmol Vis Sci 2007; 11:5085-5090. doi.org/10.1167/iovs.06-1249.
40. Nucci C., Martucci A., Martorana A., Sancesario G.M., Cerulli L. Glaucoma progression associated with altered cerebral spinal fluid levels of amyloid beta and tau proteins. Clin Exper Ophthalmol 2011; 3:279-281. doi.org/10.1111/j.1442-9071.2010.02452.x.
41. Masters C.L., Simms G., Weinman N.A., Multhaup G., McDonald B.L., Beyreuther K. Amyloid plaque core protein in Alzheimer disease and Down syndrome. Proc Natl Acad Sci USA 1985; 82:4245-4249. doi.org/10.1073/pnas.82.12.4245.
42. Grundke-Iqbal I., Iqbal K., Tung Y.C., Quinlan M., Wisniewski H.M., Binder L.I. Abnormal phosphorylation of the microtubule-associated protein tau (tau) in Alzheimer cytoskeletal pathology. Proc Natl Acad Sci USA 1986; 83:4913-4917. doi.org/10.1097/00002093-198701030-00020.
43. Bayer A.U., Ferrari F., Erb C. High occurrence rate of glaucoma among patients with Alzheimer's disease. Eur Neurol 2002; 47:165-168. doi.org/10.1159/000047976.
44. Tamura H., Kanamoto T., Kato T., Yokoyama T., Sasaki K., Izumi Y. et al. High frequency of open-angle glaucoma in Japanese patients with Alzheimer's disease. J Neurol Sci 2006; 246:79-83. doi.org/10.1016/j.jns.2006.02.00946.
45. Бачурин С.О., Шевцова Е.Ф. Возможные мишени для создания лекарственных препаратов для лечения болезни Альцгеймера: новые аспекты. Психиатрия 2008; 4-6:43-47.
47. Ricci J.-E., Gottlieb R.A., Green D.R. Caspaze-mediated loss of mitochondrial function and generation of reactive oxygen species during apoptosis. J Cell Biology 2003; 160(1):65-75. doi.org/10.1083/jcb.200208089.
48. Nowak A., Przybylowska-Sygut K., Gacek M., Kaminska A., Szaf-lik J.P. et al. Neurodegenerative genes polymorphisms of the -491A/T APOE, the -877T/C APP and the risk of primary open-angle glaucoma in the Polish populacion. Ophthalmic Genet 2013; (IGR: 15-3). doi: 10.3109/13816810.2013.838277.
49. Vickers J.C. The cellular mechanism underlying neuronal degeneration in glaucoma: parallels with Alzheimer's disease. Aust N Z J Ophthalmol 1997; 25:105-9. doi.org/10.1111/j.1442-9071.1997.tb01290.x.
50. Copin B., Brézin A.P., Valtot F., Dascotte J.C., Béchetoille A., Garchon H.J. Apolipoprotein E-promoter single-nucleotide polymorphisms affect the phenotype of primary open-angle glaucoma and demonstrate interaction with the myocilin gene. Am J Hum Genet 2002; 70(6):1575-1581. doi.org/10.1086/340733.
Для цитирования: Газизова И.Р., Зайнуллина С.Р. Нейровизуализация дегенеративных изменений при первичной открытоугольной глаукоме. Национальный журнал глаукома. 2015;14(4):72-77.


Differentiation of Gram positive and Gram negative bacteria. Descriptors: Gram Staining for Differentiation of Bacteria, cell wall structure, crystal violet dye, red saffranin.
Rapid differentiation of Gram positive and Gram negative bacteria. Descriptors: KOH Method for Gram Differentiation.
Differentiation of oxidase positive and oxidase negative bacteria. Descriptors: Oxidase Test, tetramethyl-p-phenylene diamine, enzyme oxidase.
Yeasts isolated on agar plates can be checked for spoilage potential by their ability to decarboxylate an organic acid, producing a distinctive odour. This method, originally described by EBC, was adopted by the ASBC as an international method in 2016 / 2017 and reciprocated as an international method by EBC under the same number in 2018. Descriptors: Phenolic Off Flavour (POF), decarboxylate ferulic acid to 4-vinyl guaiacol, aroma of cloves.
Descriptors: Identification of colonies (bacteria or yeasts) from agar plates or membrane filters by their capability to catabolise different nutrients.
Analysis of turbid samples (enrichments or yeast containing) and of colonies from agar plates for the presence and identification of bacteria, yeasts and/or moulds by detection of their DNA (deoxyribonucleic acid). Descriptors: Detection and Identification of Microorganisms from Turbid Liquid.
Analysis of filterable samples for the presence and identification of bacteria, yeasts and/or moulds by detection of their DNA (deoxyribonucleic acid). Descriptors: Detection and Identification of Microorganisms from Filterable Samples by Real-Time PCR (Polymerase Chain Reaction), PCR analysis, DNA Extraction, PCR thermocycling instrument, specific primers and probes systems in PCR, lysis buffer, DNA polymerase (usually TaqPolymerase), RealTime PCR thermocycling instrument, Real Time PCR, ready-to-use DNA extraction kits and PCR applications.
Descriptors: Identification of colonies (bacteria, yeasts and/or moulds) from agar plates or membrane filters by specific detection of their DNA (deoxyribonucleic acid).
Determination of the yeast cell concentration in stored pitching yeast, fermenting or stored beer. Descriptors: Haemocytometry, counting chamber, counting chambers (Thoma, Malassez, Bürker-Türk, Neubauer), counting area.
Instrumental determination of the yeast cell concentration in fermenting beer or pitching yeast. Descriptors: Electronic Counter, modifies the resistance between the electrodes, electrolyte.
Determination of the yeast cell concentration of stored pitching yeast, fermenting or stored beer with counts over 1 million cells per ml. A concentration step is necessary for samples containing less than 1 million cells. Descriptors: Photometric Determination, photometer, calibration curves.
Instrumental determination of yeast cell concentration and yeast viability in brewing yeast containing samples.
The rapid estimation of yeast fraction in a slurry. Descriptors: Centrifugation of yeast mass, alkaline treatment.
Determination of the concentration of yeast in suspension by means of its dry weight. Descriptors: Dry Weight of Yeast, centrifugation, alkaline solution.
Rapid estimation of the percentage of "viable" yeast cells by counting dead cells. Descriptors: Fluorescence Stain for yeast analysis, fluoresce under UV-light, percentage of fluorescing cells.
Estimation of the percentage of viable cells capable of reproducing in a yeast sample. Descriptors: Slide culture techniques for yeast analysis, micro-colonies.
Primary differentiation of yeasts based on cell morphology. Descriptors: cell morphology of yeasts, size, shape, vegetative reproduction of the cells, examine only pure cultures.
Quantitative estimate of the proportions of the different brewing yeast strains present in a mixed culture. Descriptors: cell colony morphologie, yeast giant colonies, long-time incubation.
The laboratory storage of brewing yeast stocks cultures over a number of years. It has been demonstrated that the genetic stability and survival of brewing yeast strains are optimal after cryopreservation at ultra-low temperatures (below -139 °C) compared to other preservation methods. The cultures may be stored in plastic tubes or straws. The present method describes the preservation in polypropylene straws under liquid nitrogen or in mechanical freezers. Descriptors: yeast storage at ultra-low temperatures, cryoprotectant agent, long-term storage, cryopreservation, dehydration, osmotic imbalance, intracellular ice.
The shipment of brewing yeast strains from a supplier laboratory to a receiving laboratory where they are to be propagated for industrial purposes. Descriptors: yeast strain transport, short-term storage, free from contaminant microorganisms.
Propagation of brewing yeast strains from stock cultures to obtain sufficient yeast to pitch the first propagation tank in the brewery. As the objective is to produce large numbers of yeast cells (not to produce beer), the propagation conditions are more flexible than in brewery fermentation, so general guidelines, as well as a standard protocol as a guide are provided. Descriptors: laboratory storage.


Captain America/Quote < Captain America. Edit. History Talk (0) Share . A "So, you got detention. You screwed up. You know what you did was wrong, but the question is how are you gonna make things right? Maybe you were trying to be cool. But take it from a guy who's been frozen for 65 years, the only way to really be cool, is to follow the rules. We all know what's right, we all know what... 19/05/2018�� The only, and I mean only, downside to this meme is that they often rely on Twitter text and we can only have two media links per post. Therefore I need you, the thread reading public, to contribute more examples of this cultural phenomenon for record keeping purposes.
It would be a gross injustice to term Captain America as a super-soldier wearing a flag costume, and wielding an indestructible shield while preventing crime.... 16/05/2018�� The second PSA comes while Peter is in detention. This has gone on to become a popular meme. The third PSA is a post-credits scene about patience. This has gone on to become a popular meme.
The left is out to kill Captain America. First, it was the internet campaign to make Captain America gay � a ridiculous hijacking of a popular American icon originally �... Captain America Memes. Updated daily, for more funny memes check our homepage.
A new meme based on a clip from �Spider-Man: Homecoming� in 2017 has gone viral this week. The clip is a Captain America PSA delivered to high school students in detention.
Anyone who lazily made a still-image meme of Captain America giving people a stern talking to needs a stern talking to. Especially given that most of the "So, you got detention" memes circulating on the Internet right now originated on Twitter.
In the 2017 film Spider-Man: Homecoming, Captain America is shown in a PSA video for students who receive detention, which includes Peter Parker. A still of him in the video is now a meme.


text:
Becoming Like Creoles: Book Endorsement
Becoming Like Creoles, book, creoles, Curtiss Paul DeYoung, endorsement, Fortress Press
Becoming Like Creoles: Living and Leading at the Intersections of Injustice, Culture, and Religion
Curtiss Paul DeYoung (Author)
Jacqueline J. Lewis (Contributor)
Micky ScottBey Jones (Contributor)
Robyn Afrik (Contributor)
Sarah Thompson Nahar(Contributor)
Sindy Morales Garcia (Contributor)
'Iwalani Ka'ai (Contributor)
The French Caribbean authors of In Praise of Creoleness (Éloge de la Créolité) exclaim, "Neither Europeans, nor Africans, nor Asians, we proclaim ourselves to be Creoles." Creoleness, therefore, becomes a metaphor for humanity in all its diversity. Unique among the many images useful for discussing diversity, Creoleness is formed within a history of injustice, oppression, and empire. Creolization offers a way of envisioning a future through the interplay between cultural diversity, injustice and oppression, and intersectionality. People of faith must embrace such metaphors and practices to be relevant and effective for ministry in the 21st century. Using biblical exposition in conversation with present day Creole metaphors and cultural research, Becoming Like Creoles seeks to awaken and prepare followers of Jesus to live and minister in a world where injustice is real and cultural diversity is rapidly increasing. This book will equip ministry readers to embrace a Creole process, becoming culturally competent and social justice focused, whether they are emerging from a history of injustice or they are heirs of privilege.
"For this South African, more and more aware of the essential creoleness of our own society locked in battle with our racist, separatist, disconnected past, this book is a revelation and an invitation to think anew about things that were always so obvious yet so elusive. The personal stories strengthen rather than distract from the core argument and rhythm of this wonderful book, brimming over with fresh, provocative, and delightful insights. This book will change hearts and minds." –Allan Aubrey Boesak, South African Black liberation theologian and human rights activist
"Becoming Like Creoles recognizes how intersectionality and cultural understandings open our eyes to a better reality. The authors sound a prophetic call to confront injustice. As personal narratives weave into biblical and theological understandings of justice, this profoundly important and insightful book challenges us to rethink and reimagine a just world." –Grace Ji-Sun Kim, Associate Professor of Theology at Earlham School of Religion and the author or editor of 16 books, including Embracing the Other.
"DeYoung's writing never fails to invigorate my theological imagination–and Becoming Like Creoles is no exception! A wise collaboration between DeYoung and powerhouse thinker-leaders Jacqueline J. Lewis, Micky ScottBey Jones, Robyn Afrik, Sarah Thompson Nahar, Sindy Morales Garcia and 'Iwalani Ka'ai, this book plunged me deeper into the word creole, uncovering the many ways in which it can expand and guide my own personal transformation as well the community transformation for which I advocate. I definitely plan to use it both personally and professionally, and hope you will too!" –Christena Cleveland, Activist, public theologian, and director of the Center for Justice and Renewal
"Becoming Like Creoles presents a uniquely biblical model for our interracial/intercultural future that offers new life for both the oppressed and oppressor in a rehumanized community. In this important work, DeYoung masterfully blends six contemporary women of color in the narrative, so as to amplify their voices rather than appropriate them. Perhaps the most important question the book answers is whether whites can be recultured and rehumanized. The answer to this question brought me joy and hope for a reconciled future." –Randy Woodley, Indigenous speaker and author of Shalom and the Community of Creation: An Indigenous Vision
Curtiss Paul DeYoung is the Chief Executive Officer of the Minnesota Council of Churches. He has also served as the Executive Director of Community Renewal Society in Chicago, and as Professor of Reconciliation Studies at Bethel University in St. Paul, MN, He is the author of Living Faith: How Faith Inspires Social Justice, and the co-editor of The People's Bible.


text:
Fredonia is a city in Louisa County, Iowa, United States. The population was 222 at the time of the 2020 census. It is part of the Muscatine Micropolitan Statistical Area.

History
Fredonia was laid out in 1836, by Alvin Clark, who had a squatters claim on the land and was surveyed by John Gilliland. It is located on the east side of the Iowa River, immediately below the junction of the Iowa and Cedar rivers. It is a part of section 20, township 75, range 4 west. It is said Alvin Clark and his brother Gibbs were the first settlers in Fredonia. As such it is one of the oldest continuously-incorporated towns in Iowa. It is sometimes claimed that Fredonia came near being the capital of Iowa and only lost by 1 vote. This however, was not a truly serious consideration in the House of Representatives, as many other names were being brought up at the time.

Geography
Fredonia is located just east of the confluence of the Iowa River and the Cedar River. The community of Columbus Junction lies to the southwest across the Iowa River.

According to the United States Census Bureau, the city has a total area of , all land.

Demographics

2010 census
As of the census of 2010, there were 244 people, 83 households, and 58 families residing in the city. The population density was . There were 93 housing units at an average density of . The racial makeup of the city was 74.6% White, 0.4% African American, 2.0% Native American, 2.5% Asian, 19.3% from other races, and 1.2% from two or more races. Hispanic or Latino of any race were 43.9% of the population.

There were 83 households, of which 44.6% had children under the age of 18 living with them, 47.0% were married couples living together, 16.9% had a female householder with no husband present, 6.0% had a male householder with no wife present, and 30.1% were non-families. 24.1% of all households were made up of individuals, and 8.4% had someone living alone who was 65 years of age or older. The average household size was 2.94 and the average family size was 3.53.

The median age in the city was 29 years. 34.8% of residents were under the age of 18; 9.1% were between the ages of 18 and 24; 25.1% were from 25 to 44; 21.3% were from 45 to 64; and 9.8% were 65 years of age or older. The gender makeup of the city was 52.9% male and 47.1% female.

2000 census
As of the census of 2000, there were 251 people, 87 households, and 64 families residing in the city. The population density was . There were 92 housing units at an average density of . The racial makeup of the city was 86.06% White, 7.97% from other races, and 5.98% from two or more races. Hispanic or Latino of any race were 31.47% of the population.

There were 87 households, out of which 35.6% had children under the age of 18 living with them, 58.6% were married couples living together, 9.2% had a female householder with no husband present, and 25.3% were non-families. 24.1% of all households were made up of individuals, and 9.2% had someone living alone who was 65 years of age or older. The average household size was 2.89 and the average family size was 3.40.

32.3% are under the age of 18, 6.8% from 18 to 24, 28.3% from 25 to 44, 21.9% from 45 to 64, and 10.8% who were 65 years of age or older. The median age was 32 years. For every 100 females, there were 97.6 males. For every 100 females age 18 and over, there were 93.2 males.

The median income for a household in the city was $30,250, and the median income for a family was $28,750. Males had a median income of $25,625 versus $18,125 for females. The per capita income for the city was $15,380. About 7.6% of families and 6.8% of the population were below the poverty line, including 11.5% of those under the age of eighteen and 4.2% of those 65 or over.

References

Cities in Iowa
Cities in Louisa County, Iowa
Muscatine, Iowa micropolitan area

redpajama_set_name: RedPajamaWikipedia


Ducks are another addition that we have wanted to make to the farm for ages, but I have been unable to find any reasonably local until now. I was extremely fortuante to get these five young adults, a pekin drake, three pekin hens and one khaki campbell duck. They are just finishing their moult and will hopefully start laying around May-June and keep us in eggs over winter. Of course little ducklings are just so cute so I do plan to try and hatch a few:) Before getting them I had also planned to breed them for meat…but we shall have to see about that. These ducks are far more intelligent than the chooks and have way more personality – I think eggs and entertainment value means they shall earn their place on the farm:) Another great thing about pekins is that they don't fly and they do flock, so I can use them to help train the puppies to work sheep (strange but true!). Chickens on the other hand don't flock, so herding them is like herding a bunch of cats and just as noisy.
Thanks to all the glorious cream that Josie is giving us on her milk, I thought it would be a great idea to have a go at making butter. As I don't have any cheese cultures at the moment, making cultured butter to get cultured buttermilk seemed like a good way to go. The process for making butter and cultured butter is the same, except for the intitial culturing bit. I was advised to keep a journal to record the failed experiments along with the successes…but of course I forgot to do that and now I am writing this from memory – not to self, when I get a jersey I *must* keep a journal of all recipes!
Cultured Cream: To culture the cream, all I did was skim it from the raw milk, then left it on the kitchen bench for 24-48 hours in a glass jar covered with a paper towel held on with an elastic band. Its is summer so it cultured fairly quickly. As it was at room temperature I just started beating it, but for the normal butter from cream that was in the fridge I let the cream stand on the bench for a little while to warm up a bit.
Step 1: Put the cream into a large stainless steel mixing bowl. Start 'whipping' the cream with hand held beaters.
Step 2: Keep beating past the 'whipped cream' stage until the cream starts to 'break' into little yellow pieces of butter.
Step 3: The buttermilk will very clearly seperate from the butter.
Step 4: Strain the buttermilk out of the bowl, keep beating astrainign until all of the buttermilk is removed.
Step 5: Add half a cup of cold water to the bowl and keep beating – this will wash the remaining buttermilk from the butter. (I discarded this, but it could be kept for the chickens).
Step 6: Push the butter into a rough ball shape with wooden spoon, strain and place in the freezer for a few minutes to firm up (but not harden).
Step 7: Remove butter from freezer and 'pat' it using wooden pats or flat wooden spoons. Keep 'patting' until all of the liquid is removed.
Step 8: Sprinkle with a small amount of salt to taste (no iodine or anti-caking agents).
Step 9: At this stage a tiny amount of olive oil can be added to keep the butter spreadable, or it can be rolled into balls, placed on wax paper and frozen. Once frozen the balls can be put into a larger container back in the freezer and won't stick together.
Personaly I prefer the taste of cultured butter, but the rest of the family can't tell the difference. Homemade butter on homemade bread with homemade jam – absolutely devine!
I've been looking through my photos for some that show how the paddocks are doing – definitely been eaten down in the past month so it will be time to start feeding hay in the near future.
And one of a litter of rescued orphaned feral farm cats that a friend is helping to raise. Everybody should be very proud of me for saying a very definite 'NO' to keeping one of them!
These photos show the thick smoke that has blanketed us for several days – the Nannup bushfire is over 100km away from us, I can't imagine what it would be like any closer.
I am babysitting my friends jersey house cow for a week while she is interstate. She is a lovely old girl (Josie the cow, not my friend;) with a dropped rumen, a broken tail, a blind quarter, an uneve udder, a dicky hip that makes her shuffle when she walks and a mumified fetus inside that means she will never have another calf, but has stayed in milk producing roughly 7 litres per day for several years and according to the vet will likely continue to do so. From the sound of all that, you would never buy a cow with all these issues, but Josie is worth her weight in gold as a patient and gentle house cow. I milked her myself for the first time using the milking machine and was extremely relieved that hse is so patient becasue those cups are like dealing with an octopus which meant putting my head and body right in the firing line if she decided to kick me.
The thought didn't even cross her mind, she just happily stood eating her dinner while I fumbled around with the octopus machine. Ok, so its only got four arms but it might have well been eight it was that tricky to get on. Machine milking is definitely quicker, but it proved to me that I really love and miss handmilking. It would be a good investment for days when I am sick or not here to milk so that someone else can do it, so I will look at getting one eventually.
Obviously I need to get a new cow first and have found one close by that seems very sweet and just what I am looking for so plan on bringing her home next week. The owner is hand milking her every day between now and then to get her into the routine before we transport her, so fingers crossed she settles in well and her production dosn't stop (we'll possibly try fostering her young half brother onto her to keep her supply up as her own calf is 9 months old and not for sale.
A couple of very bad photos from my phone.
Today we managed to get a few spots of rain, just enough to wet the horses, but not enough to wet the ground unfortunately. The clouds around us looked so promising, but the rain just slid right on past us. These photos show how brown and dry everything is at this time of year, but at least we still have plenty of pasture which should last through most of summer. While it would be nice to have some rain to wash everything and cool it down, a heavy rainfall would strip the nutrients out of the remaining pasture, so while a downpour would be nice, the negatives would outweight the benefits at this time of year.
For the time being at least. I have perservered for over four months training Charlotte the dexter to be a house cow, but its finally time to give it in and concede that she is just not cut out to be a house cow. I have learnt so much from her (such as cows can kick at such angles that horses could never even dream of, cows have pinpoint accuracy when it comes to flinging snot and all other body fluids directly at your face and you can train a cow to stand still and tolerate having her teats pulled…but you *cannot* make a cow give you milk if she dosn't want you to have it. I found out that it is even possible for a cow to hold up one quarter while her calf is on the other side. I think I tried everything in the book (literally in the book Keeping a Family Cow) as well as numerous other methods recommended by members on the family cow board, but it would take Charlotte (aka devil-cow) three days to work out how to stop my latest trick from working.
I've also found out that calling someone a 'cow' really is the nastiest insult available!
Despite all that, I would have continued milking her if I was getting enough milk for our daily needs – but it was taking at least an hour, way too much water for clean-up and costing way too much in food to persevere for less than a litre a day. It was a great experience, but Charlotte is back to being our beedf breeder (the reason we originally purchased her) and we are back to drinking plastic milk from the shop (and Lactose free UHT milk fro B2) until such time as I can find an affordable jersey house cow with a decent temperament. In the mentime, devil-cow has been put out the back with T-Bone and Matilda to grow us some beef. With any luck by July T-Bone will be old enough to cover both cows and then be ready for freezer camp towards the end of the year. I am hoping that when Matilda finally freshens, that her nicer temperament and fondness for anything food related will make her a suitable candidate for back up cow when the jersey is dried off for a few months before freshening. That is the plan anyway.
My advice fro anyone looking for a house cow – despite the 'dual purpose' breed hype, don't consider a Dexter unless it comes from milk producing lines and has previously been hand milked with a suitable production history for your needs, as this is a breed that is notorious for drying themselves up after weaning their calves and/or with holding their milk from you (but if you get a good milker, they are definitely worth their weight in gold!).


The work of Dr. Gillies has impacted all 3 aims of the ET program, with the majority focused on Aim 1: Define & characterize deregulated pathways with therapeutic relevance in subsets of human cancers. Work in this area has examined two different pathways: 1) cell surface proteins that can be targeted by imaging or therapy, and 2) energy metabolic pathways and their sequelae. Dr. Gillies and colleagues have identified targetable cell surface receptors in pancreatic, melanoma and breast cancers. For agents designed to be applied locally, Dr. Gillies and colleagues have looked for single protein targets that are expressed in the cancer or pre-cancer, that are not expressed in normal not adjacent-normal tissues. These can be targeted with homomultivalent ligands (hoMVLs) coupled to dyes or nanoparticles. For agents designed to be applied systemically, they have interrogated the gene expression arrays looking for combinations of cell surface receptors that can be targeted with heteromultivalent ligands (htMVLs). Recently, Dr. Gillies and colleagues have identified both hoMVL and htMVL targets in pancreatic cancers and melanomas, and have identified hoMVL targets for breast cancer in lymph nodes.
Srikumar T, Siegel EM, Gu Y, Balagurunathan Y, Garcia AL, Chen YA, Zhou JM, Zhao X, Gillies R, Clark W, Gamenthaler A, Choi J, Shibata D. Semiautomated Measure of Abdominal Adiposity Using Computed Tomography Scan Analysis. J Surg Res. 2019 May;237:12-21. Pubmedid: 30694786.
Bi WL, Hosny A, Schabath MB, Giger ML, Birkbak NJ, Mehrtash A, Allison T, Arnaout O, Abbosh C, Dunn IF, Mak RH, Tamimi RM, Tempany CM, Swanton C, Hoffmann U, Schwartz LH, Gillies RJ, Huang RY, Aerts HJWL. Artificial intelligence in cancer imaging: Clinical challenges and applications. CA-Cancer J Clin. 2019 Mar;69(2):127-157. Pubmedid: 30720861. Pmcid: PMC6403009.
Paul R, Schabath M, Balagurunathan Y, Liu Y, Li Q, Gillies R, Hall LO, Goldgof DB. Explaining Deep Features Using Radiologist-Defined Semantic Features and Traditional Quantitative Features. Tomography. 2019 Mar;5(1):192-200. Pubmedid: 30854457. Pmcid: PMC6403047.
Cherezov D, Goldgof D, Hall L, Gillies R, Schabath M, Müller H, Depeursinge A. Revealing Tumor Habitats from Texture Heterogeneity Analysis for Classification of Lung Cancer Malignancy and Aggressiveness. Sci Rep. 2019 Mar;9(1):4500. Pubmedid: 30872600. Pmcid: PMC6418269.
Pillai SR, Damaghi M, Marunaka Y, Spugnini EP, Fais S, Gillies RJ. Causes, consequences, and therapy of tumors acidosis. Cancer Metastasis Rev. 2019 Mar. Pubmedid: 30911978.
Hormuth DA, Sorace AG, Virostko J, Abramson RG, Bhujwalla ZM, Enriquez-Navas P, Gillies R, Hazle JD, Mason RP, Quarles CC, Weis JA, Whisenant JG, Xu J, Yankeelov TE. Translating preclinical MRI methods to clinical oncology. J Magn Reson Imaging. 2019 Mar. Pubmedid: 30925001.
Alahmari SS, Cherezov D, Goldgof D, Hall L, Gillies RJ, Schabath MB. Delta Radiomics Improves Pulmonary Nodule Malignancy Prediction in Lung Cancer Screening. IEEE Access. 2019 Jan;6:77796-77806. Pubmedid: 30607311. Pmcid: PMC6312194.
Gillies RJ, Pilot C, Marunaka Y, Fais S. Targeting acidity in cancer and diabetes. BBA. Reviews on cancer. 2019 Jan;1871(2):273-280. Pubmedid: 30708040.
Hosny A, Parmar C, Coroller TP, Grossmann P, Zeleznik R, Kumar A, Bussink J, Gillies RJ, Mak RH, Aerts HJWL. Deep learning for lung cancer prognostication: A retrospective multi-cohort radiomics study. PLoS Med. 2018 Nov;15(11):e1002711. Pubmedid: 30500819. Pmcid: PMC6269088.
Balagurunathan Y, Beers A, Kalpathy-Cramer J, McNitt-Gray M, Hadjiiski L, Zhao B, Zhu J, Yang H, Yip SSF, Aerts HJWL, Napel S, Cherezov D, Cha K, Chan HP, Flores C, Garcia A, Gillies R, Goldgof D. Semi-automated pulmonary nodule interval segmentation using the NLST data. Med Phys. 2018 Mar;45(3):1093-1107. Pubmedid: 29363773. Pmcid: PMC5952359.
Liu Y, Kim J, Balagurunathan Y, Hawkins S, Stringfield O, Schabath MB, Li Q, Qu F, Liu S, Garcia AL, Ye Z, Gillies RJ. Prediction of pathological nodal involvement by CT-based Radiomic features of the primary tumor in patients with clinically node-negative peripheral lung adenocarcinomas. Med Phys. 2018 Jun;45(6):2518-2526. Pubmedid: 29624702. Pmcid: PMC6161827.
Walton ZE, Patel CH, Brooks RC, Yu Y, Ibrahim-Hashim A, Riddle M, Porcu A, Jiang T, Ecker BL, Tameire F, Koumenis C, Weeraratna AT, Welsh DK, Gillies R, Alwine JC, Zhang L, Powell JD, Dang CV. Acid Suspends the Circadian Clock in Hypoxia through Inhibition of mTOR. Cell. 2018 Jun;174(1):72-87.e32. Pubmedid: 29861175. Pmcid: PMC6398937.
Balagurunathan Y, Beers A, Kalpathy-Cramer J, McNitt-Gray M, Hadjiiski L, Zhao B, Zhu J, Yang H, Yip SSF, Aerts HJWL, Napel S, Cherezov D, Cha K, Chan HP, Flores C, Garcia A, Gillies R, Goldgof D. Erratum: Semi-automated pulmonary nodule interval segmentation using the NLST data. Med Phys. 2018 Jun;45(6):2689-2690. Pubmedid: 29894564.
Damgaci S, Ibrahim-Hashim A, Enriquez-Navas PM, Pilon-Thomas S, Guvenis A, Gillies RJ. Hypoxia and acidosis: immune suppressors and therapeutic targets. Immunology. 2018 Jul;154(3):354-362. Pubmedid: 29485185. Pmcid: PMC6002221.
Matsumoto S, Kishimoto S, Saito K, Takakusagi Y, Munasinghe JP, Devasahayam N, Hart C, Gillies RJ, Mitchell JB, Krishna MC. Metabolic and Physiologic Imaging Biomarkers of the Tumor Microenvironment Predict Treatment Outcome with Radiation or a Hypoxia-Activated Prodrug in Mice. Cancer Res. 2018 Jul;78(14):3783-3792. Pubmedid: 29792309.
Shafiq-Ul-Hassan M, Latifi K, Zhang G, Ullah G, Gillies R, Moros E. Voxel size and gray level normalization of CT radiomic features in lung cancer. Sci Rep. 2018 Jul;8(1):10545. Pubmedid: 30002441. Pmcid: PMC6043486.
Persi E, Duran-Frigola M, Damaghi M, Roush WR, Aloy P, Cleveland JL, Gillies RJ, Ruppin E. Systems analysis of intracellular pH vulnerabilities for cancer therapy. Nat Commun. 2018 Jul;9(1):2997. Pubmedid: 30065243. Pmcid: PMC6068141.
Paul R, Hall L, Goldgof D, Schabath M, Gillies R. Predicting Nodule Malignancy using a CNN Ensemble Approach. Proc Int Jt Conf Neural Netw. 2018 Jul;2018. Pubmedid: 30443438. Pmcid: PMC6233309.
Paul R, Liu Y, Li Q, Hall L, Goldgof D, Balagurunathan Y, Schabath M, Gillies R. Representation of Deep Features using Radiologist defined Semantic Features. Proc Int Jt Conf Neural Netw. 2018 Jul;2018. Pubmedid: 30443437. Pmcid: PMC6233304.
Napel S, Mu W, Jardim-Perassi BV, Aerts HJWL, Gillies RJ. Quantitative imaging of cancer in the postgenomic era: Radio(geno)mics, deep learning, and habitats. Cancer. 2018 Dec;124(24):4633-4649. Pubmedid: 30383900.
Cherezov D, Hawkins SH, Goldgof DB, Hall LO, Liu Y, Li Q, Balagurunathan Y, Gillies RJ, Schabath MB. Delta radiomic features improve prediction for lung cancer incidence: A nested case-control analysis of the National Lung Screening Trial. Cancer Med. 2018 Dec;7(12):6340-6356. Pubmedid: 30507033. Pmcid: PMC6308046.
Kishimoto S, Oshima N, Krishna MC, Gillies RJ. Direct and indirect assessment of cancer metabolism explored by MRI. Nmr Biomed. 2018 Aug;e3966. Pubmedid: 30169896.
Gillies RJ, Balagurunathan Y. Perfusion MR Imaging of Breast Cancer: Insights Using "Habitat Imaging". Radiology. 2018 07;288(1):36-37. Pubmedid: 29714676.
Tunali I, Stringfield O, Guvenis A, Wang H, Liu Y, Balagurunathan Y, Lambin P, Gillies RJ, Schabath MB. Radial gradient and radial deviation radiomic features from pre-surgical CT scans are associated with survival among lung adenocarcinoma patients. Oncotarget. 2017 Nov;8(56):96013-96026. Pubmedid: 29221183. Pmcid: PMC5707077.
Beichel RR, Smith BJ, Bauer C, Ulrich EJ, Ahmadvand P, Budzevich MM, Gillies RJ, Goldgof D, Grkovski M, Hamarneh G, Huang Q, Kinahan PE, Laymon CM, Mountz JM, Muzi JP, Muzi M, Nehmeh S, Oborski MJ, Tan Y, Zhao B, Sunderland JJ, Buatti JM. Multi-site quality and variability analysis of 3D FDG PET segmentations based on phantom and clinical image data. Med Phys. 2017 Feb;44(2):479-496. Pubmedid: 28205306. Pmcid: PMC5834232.
Lemma S, Di Pompo G, Porporato PE, Sboarina M, Russell S, Gillies RJ, Baldini N, Sonveaux P, Avnet S. MDA-MB-231 breast cancer cells fuel osteoclast metabolism and activity: A new rationale for the pathogenesis of osteolytic bone metastases. Biochim Biophys Acta Mol Basis Dis. 2017 Dec;1863(12):3254-3264. Pubmedid: 28866133.
Baldini N, De Milito A, Feron O, Gillies RJ, Michiels C, Otto AM, Pastoreková S, Pedersen SF, Porporato PE, Sonveaux P, Supuran CT, Avnet S. Annual Meeting of the International Society of Cancer Metabolism (ISCaM): Metabolic Networks in Cancer. Front Pharmacol. 2017;8:411. Pubmedid: 28725193. Pmcid: PMC5496414.
Cherezov D, Hawkins S, Goldgof D, Hall L, Balagurunathan Y, Gillies RJ, Schabath MB. Improving malignancy prediction through feature selection informed by nodule size ranges in NLST. Conf Proc IEEE Int Conf Syst Man Cybern. 2016 Oct;2016:001939-001944. Pubmedid: 30473607. Pmcid: PMC6251413.
Athelogou M, Kim HJ, Dima A, Obuchowski N, Peskin A, Gavrielides MA, Petrick N, Saiprasad G, Colditz Colditz D, Beaumont H, Oubel E, Tan Y, Zhao B, Kuhnigk JM, Moltz JH, Orieux G, Gillies RJ, Gu Y, Mantri N, Goldmacher G, Zhang L, Vega E, Bloom M, Jarecha R, Soza G, Tietjen C, Takeguchi T, Yamagata H, Peterson S, Masoud O, Buckler AJ. Algorithm Variability in the Estimation of Lung Nodule Volume From Phantom CT Scans: Results of the QIBA 3A Public Challenge. Acad Radiol. 2016 Aug;23(8):940-952. Pubmedid: 27215408. Pmcid: PMC6237094.
Zhang X, Pagel MD, Baker AF, Gillies RJ. Reproducibility of magnetic resonance perfusion imaging. PLoS One. 2014;9(2):e89797. Pubmedid: 24587040. Pmcid: PMC3934952.
Takakusagi Y, Matsumoto S, Saito K, Matsuo M, Kishimoto S, Wojtkowiak JW, DeGraff W, Kesarwala AH, Choudhuri R, Devasahayam N, Subramanian S, Munasinghe JP, Gillies RJ, Mitchell JB, Hart CP, Krishna MC. Pyruvate induces transient tumor hypoxia by enhancing mitochondrial oxygen consumption and potentiates the anti-tumor effect of a hypoxia-activated prodrug TH-302. PLoS One. 2014;9(9):e107995. Pubmedid: 25254649. Pmcid: PMC4177858.
Bailey KM, Cornnell HH, Ibrahim-Hashim A, Wojtkowiak JW, Hart CP, Zhang X, Leos R, Martinez GV, Baker AF, Gillies RJ. Evaluation of the "steal" phenomenon on the efficacy of hypoxia activated prodrug TH-302 in pancreatic cancer. PLoS One. 2014;9(12):e113586. Pubmedid: 25532146. Pmcid: PMC4273999.
Dutta P, Martinez GV, Gillies RJ. A New Horizon of DNP technology: Application to In-vivo C Magnetic Resonance Spectroscopy and Imaging. Biophys Rev. 2013 Sep;5(3):271-281. Pubmedid: 26491489. Pmcid: PMC4610403.
Bailey KM, Wojtkowiak JW, Hashim AI, Gillies RJ. Targeting the metabolic microenvironment of tumors. Adv Pharmacol. 2012;65:63-107. Pubmedid: 22959024. Pmcid: PMC3796340.
Morse DL, Hostetter G, Balagurunathan Y, Gillies RJ, Han H. Identification of pancreatic cancer-specific cell-surface markers for development of targeting ligands. Methods Mol Biol. 2010;624:195-210. Pubmedid: 20217597. Pmcid: PMC4010309.
Black KC, Kirkpatrick ND, Troutman TS, Xu L, Vagner J, Gillies RJ, Barton JK, Utzinger U, Romanowski M. Gold nanorods targeted to delta opioid receptor: plasmon-resonant contrast and photothermal agents. Mol Imaging. 2008 Jan;7(1):50-57. Pubmedid: 18384724.
Martínez-Zaguilán R, Gillies RJ, Sánchez-Armass S. Regulation of pH in rat brain synaptosomes. II. Role of Cl-. J Neurophysiol. 1994 Jun;71(6):2249-2257. Pubmedid: 7931514.
Gillies RJ, Cook J, Fox MH, Giuliano KA. Flow cytometric analysis of intracellular pH in 3T3 cells. Am J Physiol. 1987 Jul;253(1 Pt 1):C121-C125. Pubmedid: 3605325.
Theilmann RJ, Borders R, Trouard TP, Xia G, Outwater E, Ranger-Moore J, Gillies RJ, Stopeck A. Changes in water mobility measured by diffusion MRI predict response of metastatic breast cancer to chemotherapy. Neoplasia. 6(6):831-837. Pubmedid: 15720810. Pmcid: PMC1531687.
Gillies RJ, Hoffman JM, Lam KS, Menkens AE, Piwnica-Worms DR, Sullivan DC, Weissleder R. Meeting report: high-throughput technologies for in vivo imaging agents. Mol Imaging. 4(2):98-103. Pubmedid: 16105507.


SativaGroup is a leading Canadian processor of raw Hemp Seeds and Hemp Seed Oil, both natural and seasoned, and a leading manufacturer of a wide range of Hemp based value added products. Sativalicious is our food line, SativaCare is our Skin, Body and Hair Care line and HempEssential is our targeted care line. We endeavor to formulate all products as naturally as possible as we recognize, applaud, and accommodate your growing demand for healthy, transparent and pure life essentials. You will find a complete ingredient list, both the common name and the INCI name, for every one of our products. With over 20 Hemp based products available, our goal is to provide for your daily needs.
Our mission is to supply the finest, purest, and most natural hemp based products both online and at selected retailers.
In order to offer the highest quality, our products have been tested by real people and have stood the test of time We are committed to supplying superior quality products at all times.
We are pleased to offer gift warpping suitable for all occassions. Simply click as desired.
Our products an be found a select Retail Outlet in your area. Please check back often as our retail locations are growing quickly. You may stop by at any one listed or order online.


text:
Music, Photos & Videos
Home / Music, Photos & Videos
Videos of Michael Hoover
T R O U B L E
Michael Hoover sings "T R O U B L E" at Elvis Week in 2014
Memories of Elvis
Michael Hoover and Memories of Elvis in tribute to the King of Rock and Roll. Taped at MetroVision Cable and aired round the clock public access in Prince George's County, MD on the 10th anniversary weekend of Elvis Presley' death August 1987.
It's Only Make Believe
Michael Hoover sings "It's Only Make Believe" a Conway Twitty classic at the Images finals in Memphis on August 18th, 2012.
Unchained Melody Medly – Memories of the King
Music by Michael Hoover
Michael Hoover sings Amazing Grace. From his CD "Amazing Grace". Listen Now!
http://www.michaelhoover.com/wp-content/uploads/2016/05/12-Amazing-Grace.mp3
Michael Hoover sings Amazing Grace. From his CD "The Lighthouse". Listen Now!
http://www.michaelhoover.com/wp-content/uploads/2016/05/09-The-Light-House.mp3
Michael Hoover sings American Trilogy. From his CD "Memories of Elvis Show – Live at the Opry". Listen Now!
http://www.michaelhoover.com/wp-content/uploads/2016/04/hoover_americantrilogy.mp3
Michael Hoover sings Burning Love. From his CD "Memories of Elvis Show – Live at the Opry". Listen Now!
http://www.michaelhoover.com/wp-content/uploads/2016/04/hoover_burninglove.mp3
Photos of Michael Hoover
(P) 540-720-2718 (C) 540-842-5962 | [email protected]
Michael Hoover
© Copyright Michael Hoover. All Rights Reserved


Looking for a quality made house flagpole? We carry a large selection of flagpoles designs including country star, fleur dis lis and pineapple. We also carry all the flag hardware you'll need including flag brackets, rotator rings and more.


text:
Comprehensive Evaluation of All Roof Components, Structures Recommended Before Making Decision to Reroof
By Thom Belgeri
Roof leaks are often a nuisance for a building owner or property manager. Often difficult to track down, leaks can cause damage to interior finishes and lead to tenant complaints—and, if not resolved, unhappy tenants. Those leaks can become a nightmare when a financial decision is made to replace the entire roof of the building... and it still leaks.
"Frequently, an exterior building restoration company, like Western Specialty Contractors, will get a call to come out and try to resolve the leaks. The conversation usually starts with an explanation that this is a brand new roof, that it has had issues from day one, and that the roofer has been out numerous times to satisfy the warranty to no avail. The roofer now says that the problem is not the roof, but something else. That news may be hard for a building owner to accept—after all, it was probably a significant financial investment— but most of the time the roofer is right," said Thom Belgeri, department manager of Western Specialty Contractors' St. Louis Roofing Division.
Most structures today are constructed out of many different materials that move at different rates. Marrying all of these components together is complex and, at the same time, can make the roof more vulnerable to errors and failure when reroofing.
"In roofing, details around penetrations at the parapet walls and around building systems are very critical to successful projects," said Belgeri. "Those are points where the majority of leaks occur. However, in a reroofing project, even if all the details are done correctly, it may not be enough. Often the materials located above those details has aged and weathered as well, leading to deterioration and allowing moisture through. That moisture then finds its way behind the newly installed roof."
Belgeri says it is important to review the condition of the building's components that rise above the roof level such as a penthouse, elevator shafts, stair towers, parapet walls and coping and to evaluate the parapet walls from both the interior and exterior. The most visible signs of potential avenues for water infiltration are broken/missing masonry, deteriorated mortar and sealant joints, deteriorated concrete, etc. Sometimes moisture can penetrate even what looks to be a solid wall, but may be porous. If those signs exist, there is most likely a leak.
When such repairs need to be performed, it is extremely important that the new roof is well protected and the original installer is notified, Belgeri said. If the reroofing project is just in the budgeting phase, it is important to evaluate those building components and make the repairs prior to installation of a new roof. It is not only the
This article originally appeared in the April/May 2019 issue of School Planning & Management.
Thom Belgeri can be reached at www.westernspecialtycontractors.com.
ISSA Announces Merger with Global Biorisk Advisory Council
The Time Has Come for Us to Say 'Sayonara'
Floors Need Special Care
Research & Special Reports
Dude Solutions Is Back with More Data in Their 2018 Operations Health Index
[eBook] Showing Your Work Matters: Rethink Your Reporting
5 Education Operations Management Trends to Know
Columbia Public Schools Use KPIs to Create Change
Reducing Peak Energy Demand: A Hidden Benefit of Cool Roofs


Gulaebaghavali stars Prabhudeva, Haniska Motwani, Revathy in the lead. Revathy is the star of the show.
Gulaebaghavali aka Gulebakavali movie is an out and out comedy which entertains the audience and keeps them engaged. The movie gets an average rating of 2.5 out of 5.0. The Plot: Nambi (Mansoor Ali Khan) is a don who is a head of an antique idol smuggling gang. Badri played by Prabhu Deva is his right hand. Viji (Haniska Motwani) is into trapping rich man and snatching money from them. Masha played by Revathy is an expert car thief. Badri, Viji and Munish (Ramdoss) are assigned a task to fetch the treasure from a village named Gulaebaghavali by Nambi. Masha also joins them en-route. The rest of the movie is about how they go through this roller coaster ride and decide to cheat Nambi to share the treasure between themselves. Average Critic's Rating: 2.5 Times Of India - 3.0 "There is a madcap vibe to Gulaebaghavali, a comic caper that is largely amusing and laugh-out-loud funny at a handful of moments when it manages to fully exploit the nuttiness of its premise."Read More..
"Prabhudheva, Revathi's heist comedy is enjoyable but patchy" Read More..
"Gulaebaghavali is watchable for its comedy that will appeal to the masses." Read More..


text:
Q: How can I get the current user email instead of user ID? How can I get the current user email instead of user ID? I'm using the following shortcode:
add_shortcode( 'current_user_link', 'wppbc_current_user_link' );
function wppbc_current_user_link( $atts, $content ) {
   if ( is_user_logged_in() ) {
      $id = get_current_user_id();
      // make sure to change the URL to represent your setup.
      return "Your User Page";
   }

   return ;
}

A: you can get all logged in users details by below function
<?php
    $current_user = wp_get_current_user();
    /**
     * @example Safe usage: $current_user = wp_get_current_user();
     * if ( !($current_user instanceof WP_User) )
     *     return;
     */
    echo 'Username: ' . $current_user->user_login . '
';
    echo 'User email: ' . $current_user->user_email . '
';
    echo 'User first name: ' . $current_user->user_firstname . '
';
    echo 'User last name: ' . $current_user->user_lastname . '
';
    echo 'User display name: ' . $current_user->display_name . '
';
    echo 'User ID: ' . $current_user->ID . '
';
?>

redpajama_set_name: RedPajamaStackExchange


Thank you for your interest in becoming a Puppet Channel Partner. This application has 36 questions and takes approximately 10-15 minutes to complete. Your application answers will help us to determine your eligibility in the Puppet Partner Program and help us assess which Partner Type and Partner Level you qualify for.