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PILATUS ENDS 2021 FINANCIAL YEAR FLYING HIGH
According to the latest press release of the swiss manufacturer, "the 2021 financial year was extremely successful for Pilatus, but also challenging". Despite the difficult circumstances, a new production record of 152 aircraft deliveries was set. Sales of 1.3 billion Swiss francs, an operating result of 210 million and incoming orders worth 1.7 billion francs are a very good result. The Board of Directors also underwent a change and a reinforcement.
Pilatus achieved growth in sales of 19 percent and a 35 percent higher operating result compared to the previous year. The total number of aircraft delivered is impressive: 45 PC-24s, 88 PC-12 NGXs, 17 PC-21s and 2 PC-6s, 152 aircraft all in all.
High demand in both Business Units In the Business Unit Government Aviation, Pilatus succeeded in concluding a follow-up order with France for nine PC-21s. Another highlight was the successful presentation of the PC-7 MKX, the brand-new smart basic trainer for military pilot training. There was a boom in the General Aviation markets, which greatly benefited the PC-12 NGX and PC-24.
Besides the many highlights which shaped the past year, Pilatus also had to contend with some turbulence: disruptions to supply chains and supply bottlenecks had a negative impact on production. The efficiency of the manufacturer's work processes suffered, resulting in higher costs.
Markus Bucher, CEO of Pilatus, takes a positive view of last year's result: "Thanks to a great deal of hard work and flexibility, we achieved a very good result of which the entire crew may be justifiably proud. Demand for our products and services has rarely been so high. Meeting customer expectations despite unreliable supply chains and continuing deglobalisation will, however, ensure our work remains challenging."
Bonus for all staff Once again, the 2100+ employees at the head office in Stans have received a share in the company's profits. An amount equivalent to around one and a half month's salary was paid to all as a bonus. Pilatus has also taken various measures to further enhance its attractiveness as an employer and win the most talented candidates for its future projects.
Change and reinforcement in the Board of Directors Dominik Burkart and Annette Rinck were re-elected and newly elected onto the Board of Directors.
Dominik Burkart served as a member of the Board of Directors from 2014 to 2021 and will now represent the shareholder side on the Board of Directors.
The newly elected 57-year old Annette Rinck is currently President & CEO of Leica Microsystems. Annette Rinck has over 20 years' experience in global industrial companies. She has worked at Honeywell for the past seven years, most recently as General Manager, Global Brands, and in the Building Management Systems Division. She has a PhD in Business Administration/Strategic Marketing.
Gratian Anda, who has served as Vice Chairman of the Board of Directors since 2006, did not stand for re-election. He will remain closely connected with Pilatus as a shareholder. Pilatus thanks him for his constant support and many years of service as Vice Chairman.
Lukas Gähwiler, previously a member of the Board of Directors, was elected as the new Vice Chairman.
With immediate effect, the Pilatus Board of Directors is therefore composed as follows: Hansueli Loosli (Chairman), Lukas Gähwiler (Vice Chairman), Martin P. Furrer (member), Mario Rossi (member) and the newly elected members, Dominik Burkart and Annette Rinck.
Finally, the manufacturer gave some elements concerning the evolution of its market for the current year via Hansueli Loosli, Chairman of the Board of Directors at Pilatus: "We will see further turbulence in 2022. But we have got off to a good start and we look to the future with confidence. Pilatus has a unique product range and quite simply the best products in their respective niches. We also have a good order book, which provides us with a solid foundation. The reinforced Board of Directors, together with the entire Pilatus team, will do all we can to fly Pilatus into a promising future!"
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text:
Hailiang Tang
Department of Neurosurgery, Huashan Hospital, Fudan University, China
Rintaro Hashizume
Feinberg School of Medicine, Northwestern University, United States
Ryota Tamura
School of Medicine, Keio University, Japan
Nora F. Dengler
Charité Universitätsmedizin Berlin, Germany
Front. Neurol., 17 November 2021
Sec. Neuro-Oncology and Neurosurgical Oncology
Volume 12 - 2021 | https://doi.org/10.3389/fneur.2021.769656
How Much Tumor Volume Is Responsible for Development of Clinical Symptoms in Patients With Convexity, Parasagittal, and Falx Meningiomas?
Shuhei Yamada, Noriyuki Kijima*, Tomoyoshi Nakagawa, Ryuichi Hirayama, Manabu Kinoshita, Naoki Kagawa and Haruhiko Kishima
Department of Neurosurgery, Osaka University Graduate School of Medicine, Suita, Japan
Purpose: Meningiomas are the most common primary intracranial neoplasms and clinical symptom appearance depends on their volume and location. This study aimed to identify factors that influence clinical symptoms and to determine a specific threshold tumor volume for the prediction of symptomatic progression in patients with convexity, parasagittal, and falx meningiomas.
Materials and Methods: We retrospectively studied patients with radiologically suspected convexity, parasagittal, or falx meningiomas at our institution.
Results: The data of three hundred thirty-three patients were analyzed. We further divided patients into two groups based on clinical symptoms: an asymptomatic group (250 cases) and a symptomatic group (83 cases). Univariate analysis revealed significant differences between the groups in terms of sex (p = 0.002), age at the time of volumetric analysis (p < 0.001), hyperintense lesions on T2-weighted images (p = 0.029), peritumoral edema (p < 0.001), maximum tumor diameter (p < 0.001), and tumor volume (p < 0.001). Further multivariate analysis revealed significant differences between the groups in terms of age at the time of volumetric analysis (p = 0.002), peritumoral edema (p < 0.001), and tumor volume (p < 0.001). The receiver operating characteristic curve revealed a threshold tumor volume of 21.1 ml for predicting whether a patient would develop symptoms (sensitivity 0.843, specificity 0.880, an area under the curve 0.919 [95% confidence interval: 0.887–0.951]).
Conclusion: We identified factors predictive of clinical symptoms in patients with convexity, parasagittal, and falx meningiomas and determined the first-ever threshold tumor volume for predicting symptomatic progression in such patients.
Meningiomas are the most common primary intracranial tumors, accounting for ~25–38% of all such lesions (1, 2). The number of incidentally discovered meningiomas has increased with the widespread use of neuroimaging modalities such as computed tomography and magnetic resonance imaging (MRI) (3). In fact, radiological studies have revealed that neuroimaging could incidentally reveal suspected meningioma lesions with an incidence ranging from 0.9 to 2.5% in individuals aged in their middle years and older (4, 5). On the other hand, meningiomas are often discovered because of a variety of symptoms, including motor and sensory deficits, cognitive decline, and epilepsy (6–8). However, the factors that determine whether a lesion is symptomatic remain unclear.
Meningiomas are benign neoplasms that can exhibit a variety of growth patterns (9, 10) and, eventually, 67–75% of them enlarge (7, 10, 11). In one study in which the median tumor volume was 35.7 ml (range 1.1–133.1 ml) and 90% (52 patients) were symptomatic, tumor volume was statistically significantly related to the appearance of clinical symptoms (6). In recent meta-analyses, 4.7–8.1% of patients with incidentally discovered intracranial meningiomas developed related symptoms at follow-up visits (11, 12). However, the specific locations of the tumors were not examined in either report. The location of such a tumor is important as it is related to the symptoms a patient will experience (8), as well as the clinical and biological behavior of the tumor (6, 13, 14).
Convexity, parasagittal, and falx meningiomas account for almost 50% of all meningiomas (15). In the report in which the association between tumor volume and clinical symptoms was observed in intracranial meningiomas, nearly half of the cases were skull-base meningiomas (6). Convexity, parasagittal, and falx meningiomas differ from skull-base meningiomas in that they are located in the supratentorial space and do not involve cranial nerves. Thus, the tumor volume that causes clinical symptoms differs between supratentorial and skull-base meningiomas, and it is important to analyze the tumor volume that causes clinical symptoms exclusively for convexity, parasagittal, and falx meningiomas.
The purpose of this retrospective study was to identify factors that influence clinical symptoms and to determine a specific threshold tumor volume for the prediction of symptomatic progression in patients with convexity, parasagittal, and falx meningiomas.
Study Design and Patient Selection
We conducted a retrospective case-control study of patients with primary radiologically suspected convexity, parasagittal, or falx meningiomas. We collected data from patients whose first visit was from 1990 to 2020 at our institution. We excluded patients diagnosed with neurofibromatosis, those for whom MRI Digital Imaging and Communications in Medicine (DICOM) data were not available, and those whose symptoms were unknown due to insufficient medical records of their first visit. When patients had more than one convexity, parasagittal, or falx meningioma, we selected the largest one for analysis. The Osaka University Clinical Research Review Committee approved the study (approval number 14231) and waived the need for written informed consent, as all data were retrospective.
Definition of Symptoms
We determined from their medical records whether patients had clinical findings, which we defined as clinical symptoms. When patients exhibited more than one symptom, we selected the one that mainly interfered with their daily life. We further defined neurological symptoms as excluding epilepsy or non-specific symptoms such as headache.
Volumetric Analysis
We measured the volume of each lesion using the latest MRI DICOM data for asymptomatic patients or the MRI DICOM data at the time of symptom onset for symptomatic patients. We used Horos for macOS to perform the measurements (Horos is a free and open-source code software program that is distributed free of charge under the LGPL license at Horosproject.org and sponsored by Nimble Co LLC d/b/a Purview in Annapolis, MD USA). Using T2-weighed images (T2WIs) or contrast-enhanced T1 weighted images (T1WIs) of ~5 mm slice thickness, we measured the tumor area in each slice by manually tracing the tumor boundary. Thereafter, we multiplied the sum of all the areas by the thickness between slices, including the gaps.
Tumor Diameter
We used the same MRI DICOM data as for volumetric analysis to measure tumor diameter. The maximum tumor diameter was determined using either axial, coronal, or sagittal images.
Tumor Location, Side, and Area
The lead author (SY) carefully determined the locations of the lesions via MRI, which was independently confirmed by the senior author (NKi). We divided tumor location in three ways: convexity, parasagittal angle, and falx cerebri; right, and left; frontal, middle, and occipital area. We used "frontal area" for the anterior one-third, "occipital area" for the posterior one-third, and "middle area" for the rest.
Interpretation of T2-Weighted Images
We classified lesions according to the radiologic characteristics on T2WIs. They were classified as either "T2-hyperintense" or "other" according to the brightness of the lesion. Lesions that were too heterogenous to classify were assigned to the "other" group. One case with a maximum diameter of only 1 mm was excluded from analysis because the lesion was too small to evaluate.
All statistical analyses were performed using R 3.6.3 for Windows (www.R-project.org; R Foundation for Statistical Computing, Vienna, Austria). Statistical differences for categorical variables were examined using a two-tailed Fisher's exact test. Continuous variables were assessed using the Mann-Whitney U test or the Kruskal-Wallis test adjusted by Bonferroni correction. Multivariate logistic regression analysis was performed with variables that were significant in those univariate analyses. The thresholds were calculated by receiver operating characteristic (ROC) analysis using the distance from the upper left-hand corner (16). Probability values <0.05 were considered significant.
Overall Patient Cohort
Figure 1 illustrates the flow of patient selection. The data of 333 patients (84 male and 249 female) were analyzed. The median age at volumetric analysis was 70 years (range 23–90 years). The median tumor volume and the median maximum tumor diameter were 8.2 ml (range 0.1–188.9 ml) and 30 mm (range 5–100 mm), respectively. We further divided patients into two groups based on clinical symptoms: an asymptomatic group (250 cases) and a symptomatic group (83 cases).
Figure 1. Flow of patient selection and classification.
Comparison Between the Asymptomatic and Symptomatic Groups
Table 1 summarizes the characteristics of each group. Univariate analysis revealed significant differences between the groups in terms of sex (p = 0.002), age at the time of volumetric analysis (p < 0.001), hyperintense lesions on T2WIs (p = 0.029), peritumoral edema (p < 0.001), maximum tumor diameter (p < 0.001), and tumor volume (p < 0.001, Figure 2A). For multivariate analysis, the maximum tumor diameter was excluded as it is a similar metric to tumor volume (17). Multivariate analysis revealed significant differences between the groups in terms of age at the time of volumetric analysis (p = 0.002), peritumoral edema (p < 0.001), and tumor volume (p < 0.001). The odds ratio (OR) for peritumoral edema was 5.94 (95% confidence interval [CI]: 2.74–12.86).
Table 1. Characteristics of 333 patients and tumors.
Figure 2. (A) Box-and-whisker plots representing tumor volume of an asymptomatic group and symptomatic group. The median tumor volume of the asymptomatic group and the symptomatic group were 5.0 ml and 45.7 ml, respectively. P-value for the Mann-Whitney U test: <0.001. (B) Receiver operating characteristic curve for predicting which patients will become symptomatic via tumor volume. Area under the curve: 0.919 (95% confidence interval: 0.887–0.951). Threshold for tumor volume: 21.1 ml. Sensitivity: 0.843. Specificity: 0.880.
Thresholds for Predicting Development of Clinical Symptoms
Patients in the symptomatic group experienced motor deficits (37 cases), epilepsy (18 cases), gait disorder (seven cases), visual impairment (seven cases), cognitive decline (six cases), aphasia (four cases), headaches (two cases), sensory deficits (one case), and a subcutaneous mass (one case). The ROC curve revealed a threshold tumor volume of 21.1 ml for predicting whether a patient would develop symptoms, with a sensitivity of 0.843, a specificity of 0.880, and an area under the curve (AUC) of 0.919 (Figure 2B, 95% CI: 0.887–0.951). In addition, a threshold maximum tumor diameter of 40 mm may also be a reliable marker for predicting which patients will become symptomatic, with a sensitivity of 0.819, a specificity of 0.840, and an AUC of 0.893 (95% CI: 0.856–0.930). For 13 patients in the symptomatic group, we obtained MRI DICOM data when they had been asymptomatic at their first visit. Of these, the 21.1-ml and 40-mm threshold correctly predicted the development of symptoms in seven cases (54%).
Threshold for Predicting Development of Neurological Symptoms
When focusing only on neurological symptoms (62 cases), the threshold for tumor volume was also 21.1 ml (sensitivity 0.871, specificity 0.880, AUC 0.937 [95% CI: 0.910–0.965]). The threshold for maximum tumor diameter for prediction of neurological symptoms was almost the same as that for all symptoms: 41 mm (sensitivity 0.839, specificity 0.856, AUC 0.914 [95% CI: 0.880–0.948]).
Comparison by Age at the Time of Volumetric Analysis
When divided into three age groups; <65, 65–74, 75 ≤, the rates of symptomatic patients were 40.7, 24.6, and 9.9%, and the ORs for presenting clinical symptoms were 1 (Reference), 0.47 (95% CI: 0.27–0.84), and 0.16 (95% CI: 0.08–0.33), respectively. In all age groups, the tumor volume was significantly larger in the symptomatic than in the asymptomatic group (p < 0.001, Table 2). The threshold for predicting patients in which symptoms would develop was similar: 21.9 ml for patients <65 years, 19.0 ml for patients 64–74 years, and 21.1 ml for patients ≥75 years.
Table 2. Comparison by age at the time of volumetric analysis.
Comparison by Tumor Location
Tumor volume of the asymptomatic and symptomatic group based on tumor location is shown in Table 3. For all locations, tumor volume was significantly larger in the symptomatic than in the asymptomatic group (p < 0.001). Falx meningiomas had a slightly lower threshold for symptomatic progression than other locations.
Table 3. Comparison by tumor location.
Correlation Between Tumor Volume and Tumor Side/Area
Table 4 displays the difference in tumor volume between the asymptomatic and symptomatic groups, depending on the side or area of the tumor. For all areas, the symptomatic group had significantly larger tumor volume than the asymptomatic group (p < 0.001). The threshold for predicting patients to develop clinical symptoms was also around 21.1 ml for all areas except the occipital area of the left hemisphere.
Table 4. Correlation between tumor side/area and tumor volume (ml).
Comparison by WHO Grade
Thirty-three patients in the asymptomatic and 77 in the symptomatic group received surgical treatment. Of the 110 patients, the meningiomas of 90 (81.8%) were World Health Organization (WHO) grade I, 10 (9.1%) were WHO grade II, 3 (2.7%) were WHO grade III, and 7 (6.4%) were not mentioned in WHO grade. There were no significant differences between patients with WHO grade I and those with WHO grade II/III meningiomas, except in the maximum tumor diameter, which was larger in the latter than in the former (Table 5).
Table 5. Comparison of WHO grade I and grade II/III meningioma.
In the present study, we identified factors that are related to clinical symptoms of patients with convexity, parasagittal, and falx meningiomas, and, to our knowledge, we determined the first-ever threshold of tumor volume for predicting symptomatic progression in such patients. This may allow clinicians to predict when a growing, asymptomatic meningioma will become symptomatic. Currently, observation is the first choice for management of patients with asymptomatic meningiomas (18); these results may be useful to determine the necessity of treatment and its appropriate timing.
In this study, we also determined a threshold maximum tumor diameter of 40 mm for the prediction of symptomatic progression of patients (sensitivity 0.819, specificity 0.840, AUC 0.893). However, a tumor volume of 21.1 ml was a more accurate threshold (sensitivity 0.843, specificity 0.880, AUC 0.919). Maximum tumor diameter and tumor volume are highly correlated (17). However, tumors do not always grow in the direction of their maximum diameter, which may be why we discovered tumor volume to be the more accurate predictive factor. Maximum tumor diameter is one of the most convenient clinical metrics; however, our results indicate that the development and widespread use of a simple method to measure tumor volume is needed.
Meningiomas manifest in a variety of symptoms (8), including non-specific symptoms such as headaches and dizziness (7). Such non-specific symptoms make clinicians wonder if interventions such as surgery or radiotherapy are required for the existing meningioma. In this study, we also calculated thresholds for tumor volume and maximum tumor diameter to predict the development of neurological symptoms. However, the thresholds were similar to those for all clinical symptoms. Therefore, it may be less important for clinicians to examine whether non-specific symptoms are caused by a given meningioma.
The hemisphere in which glioblastomas and strokes occur affects the symptoms that the patient experiences (19, 20); however, in this study of meningiomas, we detected no differences between hemispheres. This may be because few patients presented with cognitive decline (7%) or aphasia (5%). The low threshold of the tumor volume only in the occipital area of the left hemisphere may be due to the small number of symptomatic patients itself. Falx meningiomas also had a lower threshold for symptomatic progression than other locations, but as in previous studies (21–23), the number of cases may not have been sufficient. Therefore, further large-scale studies are needed to validate our location-specific findings.
In multiple meta-analyses (11, 24), a T2-hyperintense sign was correlated with radiological progression, and peritumoral edema was the only imaging metric that correlated with symptomatic progression, which was confirmed in this study. Since T2WIs may be appropriate for follow-up of untreated meningiomas (25), symptom-related radiological indicators that do not require contrast-enhanced T1WIs are needed.
We should note that this study has several limitations. The first is the fact that this was a single-center, retrospective study conducted in Japan. As Japan has the largest number of MRIs per unit population in the world (26), a larger proportion of small, asymptomatic meningiomas may be detected than in other countries. This would have lowered the thresholds of tumor volume and maximum tumor diameter for predicting symptomatic progression of patients in this study. The second limitation is the possibility of errors in volumetric measurements. Volumetric measurement may be inaccurate especially for small tumors (27), and manual segmentation may be inconsistent (28). Finally, this study was conducted on radiologically presumed meningiomas; therefore, 2.9–3.4% of our study population may actually have had other tumors (10, 29).
In the present study, we identified factors predictive of clinical symptoms in patients with convexity, parasagittal, and falx meningiomas and, to our knowledge, determined the first-ever threshold tumor volume for predicting symptomatic progression in such patients. These results may be useful in allowing clinicians to estimate when a growing, asymptomatic meningioma will develop clinical symptoms, thereby improving management of patients with the disease.
The original contributions presented in the study are included in the article/supplementary material, further inquiries can be directed to the corresponding author.
The studies involving human participants were reviewed and approved by Osaka University Clinical Research Review Committee. Written informed consent for participation was not required for this study in accordance with the national legislation and the institutional requirements.
SY and NKi contributed to the concept, drafting, and writing the manuscript. TN contributed to the acquisition of data. RH and NKa contributed to the manuscript editing. MK contributed to the provision of insightful thought and design. HK contributed to the study supervision. All authors contributed to the article and approved the submitted version.
We would like to thank Editage (www.editage.com) for English language editing.
ROC, receiver operating characteristic; OR, odds ratio; CI, confidence interval; AUC, area under the curve; WHO, World Health Organization.
1. Claus EB, Bondy ML, Schildkraut JM, Wiemels JL, Wrensch M, Black PM. Epidemiology of intracranial meningioma. Neurosurgery. (2005) 57:1088–94. doi: 10.1227/01.NEU.0000188281.91351.B9
2. Ostrom QT, Patil N, Cioffi G, Waite K, Kruchko C, Barnholtz-Sloan JS, et al. Statistical report: primary brain and other central nervous system tumors diagnosed in the United States in 2013–2017. Neuro Oncol. (2020) 22:iv1–iv96. doi: 10.1093/neuonc/noaa200
3. Islim AI, Kolamunnage-Dona R, Mohan M, Moon RDC, Crofton A, Haylock BJ, et al. prognostic model to personalize monitoring regimes for patients with incidental asymptomatic meningiomas. Neuro Oncol. (2020) 22:278–89. doi: 10.1093/neuonc/noz160
4. Vernooij MW, Ikram MA, Tanghe HL, Vincent AJPE, Hofman A, Krestin GP, et al. Incidental findings on brain MRI in the general population. N Engl J Med. (2007) 357:1821–8. doi: 10.1056/NEJMoa070972
5. Bos D, Adams HHH, Zonneveld HI, Verlinden VJA, Verbruggen JGJ. Course of incidental findings on brain MR images: the population. Radiology. (2016) 281:507–15. doi: 10.1148/radiol.2016160218
6. Kauke M, Safi AF, Stavrinou P, Krischek B, Goldbrunner R, Timmer M. Does meningioma volume correlate with clinical disease manifestation irrespective of histopathologic tumor grade? J Craniofac Surg. (2019) 30:e799–802. doi: 10.1097/SCS.0000000000005845
7. Kim KH, Kang SJ, Choi J-W, Kong D-S, Seol HJ, Nam D-H, et al. Clinical and radiological outcomes of proactive Gamma Knife surgery for asymptomatic meningiomas compared with the natural course without intervention. J Neurosurg. (2019) 130:1740–9. doi: 10.3171/2017.12.JNS171943
8. Fathi AR, Roelcke U. Meningioma. Curr Neurol Neurosci Rep. (2013) 13:337. doi: 10.1007/s11910-013-0337-4
9. Hashiba T, Moto NH, Izumoto S, Suzuki T, Kagawa N, Maruno M, et al. Serial volumetric assessment of the natural history and growth pattern of incidentally discovered meningiomas: clinical article. J Neurosurg. (2009) 110:675–84. doi: 10.3171/2008.8.JNS08481
10. Behbahani M, Skeie GO, Eide GE, Hausken A, Lund-Johansen M, Skeie BS. A prospective study of the natural history of incidental meningioma-Hold your horses! Neuro Oncol Pract. (2019) 6:438–50. doi: 10.1093/nop/npz011
11. Nakasu S, Nakasu Y. Natural history of meningiomas: review with meta-analyses. Neurol Med Chir (Tokyo). (2020) 60:109–20. doi: 10.2176/nmc.ra.2019-0213
12. Islim AI, Mohan M, Moon RDC, Srikandarajah N, Mills SJ, Brodbelt AR, et al. Incidental intracranial meningiomas: a systematic review and meta-analysis of prognostic factors and outcomes. J Neurooncol. (2019) 142:211–21. doi: 10.1007/s11060-019-03104-3
13. Maiuri F, Mariniello G, Guadagno E, Barbato M, Corvino S, Del Basso De Caro M, et al. grade, proliferation index, and progesterone receptor expression are different according to the location of meningioma. Acta Neurochir (Wien). (2019) 161:2553–61. doi: 10.1007/s00701-019-04084-z
14. Hashimoto N, Rabo CS, Okita Y, Kinoshita M, Kagawa N, Fujimoto Y, et al. Slower growth of skull base meningiomas compared with non–skull base meningiomas based on volumetric and biological studies. J Neurosurg. (2012) 116:574–80. doi: 10.3171/2011.11.JNS11999
15. Sun C, Dou Z, Wu J, Jiang B, Iranmanesh Y, Yu X, et al. The preferred locations of meningioma according to different biological characteristics based on voxel-wise analysis. Front Oncol. (2020) 10:1412. doi: 10.3389/fonc.2020.01412
16. Akobeng AK. Understanding diagnostic tests 3: receiver operating characteristic curves. Acta Paediatr Int J Paediatr. (2007) 96:644–7. doi: 10.1111/j.1651-2227.2006.00178.x
17. Ishi Y, Terasaka S, Yamaguchi S, Yoshida M, Endo S, Kobayashi H, et al. Reliability of the size evaluation method for meningiomas: maximum diameter, ABC/2 formula, and planimetry method. World Neurosurg. (2016) 94:80–8. doi: 10.1016/j.wneu.2016.06.108
18. Goldbrunner R, Minniti G, Preusser M, Jenkinson MD, Sallabanda K, Houdart E, et al. EANO guidelines for the diagnosis and treatment of meningiomas. Lancet Oncol. (2016) 17:e383–91. doi: 10.1016/S1470-2045(16)30321-7
19. Baumann C, Tichy J, Schaefer JH, Steinbach JP, Mittelbronn M, Wagner M, et al. Delay in diagnosing patients with right-sided glioblastoma induced by hemispheric-specific clinical presentation. J Neurooncol. (2020) 146:63–9. doi: 10.1007/s11060-019-03335-4
20. Foerch C, Misselwitz B, Sitzer M, Berger K, Steinmetz H, Neumann-Haefelin T. Difference in recognition of right and left hemispheric stroke. Lancet. (2005) 366:392–3. doi: 10.1016/S0140-6736(05)67024-9
21. Das KK, Gosal JS, Sharma P, Mehrotra A, Bhaisora K, Sardhara J, et al. Falcine meningiomas: analysis of the impact of radiologic tumor extensions and proposal of a modified preoperative radiologic classification scheme. World Neurosurg. (2017) 104:248–58. doi: 10.1016/j.wneu.2017.04.159
22. Zuo FX, Wan JH, Li XJ, Qian HP, Meng XLA. proposed scheme for the classification and surgical planning of falcine meningioma treatment. J Clin Neurosci. (2012) 19:1679–83. doi: 10.1016/j.jocn.2012.01.034
23. Chung S-B, Kim C-Y, Park C-K, Kim DG, Jung H-W. Falx meningiomas: surgical results and lessons learned from 68 cases. J Korean Neurosurg Soc. (2007) 42:276. doi: 10.3340/jkns.2007.42.4.276
24. Sughrue ME, Rutkowski MJ, Aranda D, Barani IJ, McDermott MW, Parsa AT. Treatment decision making based on the published natural history and growth rate of small meningiomas. J Neurosurg. (2010) 113:1036–42. doi: 10.3171/2010.3.JNS091966
25. Boto J, Guatta R, Fitsiori A, Hofmeister J, Meling TR, Vargas MI. Is contrast medium really needed for follow-up MRI of untreated intracranial meningiomas? Am J Neuroradiol. (2021) 42:1421–8. doi: 10.3174/ajnr.A7170
26. Matsumoto M, Koike S, Kashima S, Awai K. Geographic distribution of CT, MRI and PET devices in Japan: a longitudinal analysis based on national census data. PLoS ONE. (2015) 10:e0126036. doi: 10.1371/journal.pone.0126036
27. Pan HC, Cheng FC, Sun MH, Chen CCC, Sheehan J. Prediction of volumetric data errors in patients treated with Gamma Knife radiosurgery. Stereotact Funct Neurosurg. (2007) 85:184–91. doi: 10.1159/000101297
28. Mazzara GP, Velthuizen RP, Pearlman JL, Greenberg HM, Wagner H. Brain tumor target volume determination for radiation treatment planning through automated MRI segmentation. Int J Radiat Oncol Biol Phys. (2004) 59:300–12. doi: 10.1016/j.ijrobp.2004.01.026
29. Jadid KD, Feychting M, Höijer J, Hylin S, Kihlström L, Mathiesen T. Long-term follow-up of incidentally discovered meningiomas. Acta Neurochir (Wien). (2015) 157:225–30. doi: 10.1007/s00701-014-2306-3
Keywords: convexity meningioma, falx meningioma, parasagittal meningioma, symptomatic progression, tumor volume
Citation: Yamada S, Kijima N, Nakagawa T, Hirayama R, Kinoshita M, Kagawa N and Kishima H (2021) How Much Tumor Volume Is Responsible for Development of Clinical Symptoms in Patients With Convexity, Parasagittal, and Falx Meningiomas? Front. Neurol. 12:769656. doi: 10.3389/fneur.2021.769656
Received: 02 September 2021; Accepted: 25 October 2021;
Hailiang Tang, Fudan University, China
Rintaro Hashizume, Northwestern University, United States
Ryota Tamura, Keio University, Japan
Nora F. Dengler, Charité—Universitätsmedizin Berlin, Germany
Copyright © 2021 Yamada, Kijima, Nakagawa, Hirayama, Kinoshita, Kagawa and Kishima. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.
*Correspondence: Noriyuki Kijima, n-kijima@nsurg.med.osaka-u.ac.jp
Meningioma: From Basic Research to Clinical Translational Study, Volume II

redpajama_set_name: RedPajamaCommonCrawl


Items where Subject is "Psychology > Psychology"
Brierley-Jones, Lyn, Crawley, Rosalind, Ayers, S and Lomax, S (2013) Stillbirth and Stigma: the spoiling and repair of multiple social identities. In: BSA 45th Medical Sociology Annual Conference, Wednesday 11th to Friday 13th September 2013, University of York, UK.
Owens, Rebecca (2017) The Role of Life History Variables in Male Competitive Behaviour. Doctoral thesis, University of Sunderland.
Roddy, Jeannette (2016) Principles of counseling and psychotherapy: Learning the essential domains and nonlinear thinking of master practitioners. Counselling and Psychotherapy Research, 16 (1). pp. 74-75.
Wilkie, Stephanie (2008) Atmosphere in English football: Relationships with Stadium Characteristics, supporter demographics and moving to a new ground. In: British Psychological Society Annual Conference, April 2008, Dublin.
Wilkie, Stephanie and Clouston, Laura (2015) Environment Preference and Environment Type Congruence: Effects on Perceived Restoration Likelihood and Restorative Outcomes. In: British Psychological Society Annual Conference, 5 - 7 May 2015, Liverpool.
Wilkie, Stephanie and Stavridou, A (2013) Influence of environmental preference and environment type congruence on judgements of restoration potential. In: Environmental Design Research Association 44th Annual Conference, 29 May - 01 June 2013, Providence R.I., USA.
Wilkie, Stephanie, Tan, Q and O'Lynn, J (2013) More than bricks and mortar: Determining how the psychological qualities of home places influence resident well-being. In: Environmental Design Research Association 44th Annual Conference, 29 May - 01 Jun 2013, Providence R.I., USA.
This list was generated on Thu Apr 18 17:25:28 2019 BST.


Anyone with even the slightest interest in theatre has probably seen a production or two of William Shakespeare's Hamlet in their lifetime. Considered by many to be Shakespeare's – if not the world's – greatest play, it's one-third ghost story, one-third dysfunctional family drama, and one-third revenge tale. It's now the first-ever Shakespeare play to be mounted on the Nellie W. Codding stage at the Spreckels Performing Arts Center. Artistic Director Sheri Lee Miller helms the production which runs through February 17.
Something is rotten in the state of Denmark. A spirit claiming to be the late King has appeared to Prince Hamlet to inform him he was poisoned by his own brother Claudius, who then married the widowed queen Gertrude and usurped the throne. He has one simple request of Hamlet – revenge!
An extremely effective addition is a live music "soundscape" composed and performed by Nancy Hayashibara. Accompanying many scenes, Hayashibara's contribution to this production's success cannot be overstated.


text:
White Guilt–Whips, Chains, And Atonement Are Never Enough
Sheldon Miller signed up for Whiteness – A Penitential Curse And How To Atone For It, a non-degree course at a local university, part of its continuing education program. The program was touted by its administrators, group leaders, and students as one of the most prestigious in the area – taught and attended by PhDs with practical experience in the subjects taught. Courses ranging from literary Naturalism, Advanced Number Theory, the Bach Cantatas, and the genius of Giotto and Machiavelli were all oversubscribed. The retirees who had led lives of intellectual vigor if not virtuosity could not seem to hang up their spurs and clamored for space at the university's academic smorgasbord.
Sheldon had been a regular student of the Arts and Literature curriculum of the program, enjoying the give and take over challenging and often contentious works of fiction. He had been thoroughly engaged by a recent course on Ibsen in which the instructor had deconstructed the major plays through a Nihilistic lens. Hedda Gabler, he contented was the Nietzschean hero, a woman of powerful, amoral, indomitable will. Rebekka West and Hilde Wangel were cut from the same cloth, women of irreconcilable ambition, indomitable will, and amoral purpose.
It was with some some surprise that his fellow students learned that he had signed up for the 'racism course', not only because of Sheldon's lifelong pursuit of literature, but because of his equally long engagement in progressivism and social reform. His colleagues knew and respected him for his Freedom Rides, sit-ins, later support for the more radical civil rights movements of H. Rap Brown and Stokely Carmichael, his association with the ideas of Louis Farrakhan, and his passionate participation in all things Black Lives Matter.
He was especially moved by the contention that America is systemically racist, that white supremacy is the legacy of Western civilization, and that the true revolution of the black man had not yet come. Whites first had to pay their dues for slavery, oppression, racist ignorance, and historical myopia.
How could anyone look at the Palais de Versailles or Westminster without seeing the blood of Africans dripping from the walls. The grandeur of Western civilization, the Renaissance, the Enlightenment, and the revolutionary democracy of France and the United States was nothing but window dressing. The so-called great art and ideas of these eras was no more than a vulgar display of white nationalism, colonialism, and imperialism.
As a Jew, Sheldon could relate to Atonement, an acceptance of guilt and the necessary consequence of punishment. We try to be good, but fall off the moral wagon so easily. Simple atonement for the sins of the past cannot be enough. Christians believe that Jesus Christ, Son of God, came down from his seat at the right hand of his Father to die on the cross for the forgiveness of the sins of mankind. Individual forgiveness was not possible given the magnitude of the sins committed before his coming, their ubiquity, and their desultory treatment.
Easy for them to say, thought Sheldon, have a deus ex machina come down from the clouds, do an Easter Passion, die heroically for all mankind, then go back to his celestial paradise.
We Jews know better, said Sheldon. Sin, guilt, and atonement are never ending. There can be no forgiveness, only acknowledgement of the perpetual indignities against one another for all time. The Wailing Wall is there for a reason. We must wail and rail against injustice, hoping that God will show us a way to make good for our sinful past.
And so it was a given that Sheldon would become a progressive in thought, word, and deed. He was a true believer in the calumny of white supremacy, the innate, inherent superiority of the black man, and the necessity of atoning for the sins of slavery, racism, and oppression.
Sheldon took every opportunity to expose himself to the anger and hatred of black people. He went to Black Lives Matter rallies and demonstrations not only to show support for the movement but to be spat upon, to be called 'racist', to be scorned, tarred, and beaten. He deserved it all. No punishment from former slaves would ever be too harsh.
So when he saw the 'racism' offering in the university catalogue, he was quick to sign up, and looked forward to the class like no other he had ever taken.
On the first day of class he saw that he was in good company. The class was even more Jewish than most (so many Jews in fact were enrolled in the program, that no classes were held on Jewish holidays), and within an hour he knew that he was among the like-minded. The instructor, a well-credentialed older black man recruited from out of bounds – a ringer, for there were scant few black people either in the student body or among instructors.
Yet this departure from protocol was exactly what the students wanted. It was one thing to be reminded of white dereliction by an old Jewish teacher; another altogether to be harangued and verbally abused by a youngish black man.
Leroy P. Jones was just what the doctor ordered – a shiny shaved bald headed, tall, imposing, and vocally impressive black man. No academic trifle he, no on-the-one-hand-on-the-other parsing of the truth. There was no give or accommodation to the man. He was there to abuse, brutalize, and shame the class until they dropped on their knees and begged for more.
One would have thought that with every nook and cranny of American society steaming with racial invective; and where black commentators, journalists, and editors were given their head and used all manner of formerly unconscionable racist language, the last thing that Sheldon or anyone else for that matter would want to hear was more of the same. Yet the desire to be perpetually punished with evermore harsh abuse, to be subject to the righteous tyranny of the black man, to be forced to admit universal crimes against black humanity seemed to have no bounds.
The class was filled to overflowing, camp chairs filled every empty space, and standing room only provided.
The booming voice of Mr. Jones could be heard far down the halls. It rose and fell like that of a Southern preacher, imploring, chastising, beseeching, but above all damning and condemning. "You, white people", he shouted, "are not part of the problem. You are the problem. You are racist to the core, hateful, scornful, dismissive of your black brothers and sisters. You have abused, enslaved, and brutally treated them for centuries and you continue to do so. You cannot stop because your racism is systemic, hardwired into your lily white genes. Make amends! Do it now".
The class filed out of the classroom quietly and pensively. There was none of the usual banter and small talk. They sought shelter, some measure of solace after so much harsh, brutal truth.
Most of the other students, also leaving their classrooms at the end of the hour, were chipper and upbeat as usual. They had been piqued with interest by the lectures and discussions just completed. While most had read of the 'racism' offering in the catalogue, few were tempted. It was enough to see black faces everywhere shouting at them. To money to hear it close up would never happen.
So Sheldon felt good about himself and the class. It was right and just to be confronted head on by his own systemic racism, and to realize the extent of his sin and moral negligence.
Again, one would assume that after such a haranguing, anyone would head to their local bar for some happy talk, but not Sheldon. Mr. Jones had simply stirred the pot of vile things. Sheldon wanted more hurt and pain, and more still. He bowed his head when passing black people on the street, reluctant to look them in the eyes. His shame, his internal pain, his guilt became more a part of him than ever before.
Posted by Ron Parlato at 11:26 AM
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As part of its ongoing digital strategy, The Royal Borough of Kensington, Chelsea and Westminster is increasing efficiency and improving service delivery through the use of innovative mobile apps.
Join us at Kensington Town Hall to discover how officers across planning and environmental services have removed the need to return to the office to rekey information and are now able to carry out more visits and inspections using intuitive mobile apps.
"Having chosen NDL's technology our team created a sandbox environment to create mobile apps, leading to a phased implementation approach with the first apps being for pest control, market inspectors and planning. Although we've experienced some challenges along the way, the outcomes have met the needs of each of the service areas - to be more efficient."
There are two sessions available for this seminar - please register for either the morning or the afternoon option.


text:
'There are a lot of killers'
Day in and day out, Planned Parenthood uses our money to kill innocent babies. When will it stop?
Most of us know that Bill O'Reilly, Fox News commentator, hosted an interview with President Donald Trump prior to the Super Bowl. During that interview, an apparently controversial exchange occurred:
Trump said he would appreciate any assistance from Russia in the fight against ISIS terrorists, adding that he would rather get along with the former Cold War-era foe than otherwise.
"But, [Putin] is a killer," O'Reilly said.
"There are a lot of killers," Trump responded, "We've got a lot of killers. What do you think? Our country's so innocent?"
Most of the public comments about this, at least those that I saw, were nothing less than sanctimonious garbage. After all, there are a lot of killers in this nation, as evidenced by the fact that more than 60 million preborn babies are dead.
Perhaps the only difference between Russian "killers" and our own is that, here in America, the killers are defined as medical professionals who provide a reproductive health service to their customers. Chilling but true.
We see this once again in a recent video released by Live Action. The organization's investigative team called Planned Parenthood affiliates around the nation, asking if the particular Planned Parenthood facility provided ultrasound to its pregnant clients so that the client could learn the health status of her preborn baby. Live Action captured the responses on video, which include the following:
"Oh, we won't be able to tell you if it's healthy or the gender," says a Planned Parenthood staff member in Farmington, New Mexico. "If you're, you know – we specialize in abortions. You know, that's what our ultrasounds are for, to see how far along the, um, patient is."
At Planned Parenthood in St. Paul, Minnesota, a worker states, "We do [ultrasounds] when, um, when performing abor – um, abortion procedures."
In Corning, New York, a Planned Parenthood staff member explains, "No, we only do – we only do ultrasounds if you are terminating."
"We do have to do an ultrasound with an abortion, but we don't offer them for – we can't do anything to make sure that the pregnancy's fine," says a Planned Parenthood employee in St. Louis, Missouri.
The end game for Planned Parenthood is that sonograms are used specifically to assist in the commission of an abortion that renders the child dead. Planned Parenthood is not in the affirmation of life business; it is in the ending of life business.
Lila Rose, founder of Live Action, has uncovered another in a long line of ugly truths about Planned Parenthood's abortion business: Quotas rather than babies matter! In addition, Live Action has captured documented evidence that Planned Parenthood uses incentives to lure expectant mothers into its chambers of horror because its affiliates are under constant pressure to keep the revenue stream up, even if it means encouraging women who might not be thinking of aborting their children to do so.
Trump is right. There are a lot of killers in America.


You're craving acceptance. A place to belong. You've found it, but the expectations of your friends are causing crazy friction with your family. Your social agenda doesn't fit with the rules of home. How far do you go to make your friends happy without completely destroying yourself in the process?


Topics: Conditions Treated, Bunions, Bunionette, Common Nail Problems, and Diabetic Foot Care.
Age: It went live on October 6th 1998, making it over 19 years, 6 months old.
Its local IP address is 64.202.189.170. It is hosted by Godaddy.com Inc (Arizona, Scottsdale,) using Apache web server. There are 2 Nameservers, ns02.domaincontrol.com, and ns01.domaincontrol.com.


text:
Paul Kovacs is the new Junior Heavyweight Australian Boxing Champion after winning his fight in three rounds at the Australian Amateur Boxing Championships in Hobart. Max Fleet
Kovacs monsters his rival
by Vince Habermann
8th Feb 2012 5:00 AM
GIANT Bundaberg 14-year-old Paul Kovacs stood tall and delivered to win the 86kg division of the Australian Boxing Championships in Hobart on Saturday night.
The Shalom College Year 10 student, who is already 189cm tall and is still growing, is known in boxing circles as the "Bundy Bear" and scored a points victory over three rounds against Western Australian Andy Murphy.
His proud father and coach Attila, who established the Attila's Boxing Academy 12 months ago, said points were even after the first round.
"But by the end of the second round he was one in front after he landed a big hit on him that counted. Then, in the third, he really came to power to win the fight," Attila said.
Born in Nambour, Paul has lived in Bundaberg for the past 13 years, but he took up the sport less than two years ago.
A Golden Gloves winner late last year, it was his first shot at a national title and he was very happy.
"I've only had seven fights but I've won five of them. Because of my size it's hard for me to get matches, because hardly anyone wants to fight me and when I do get a fight, it's usually against a 16-year-old or someone older or heavier," Paul said.
"It's all thanks to my dad. He trains me and I couldn't have done it without him."
Paul said he took up boxing for fitness but now it was his passion and his long-term goal was to win gold at the 2016 Olympics.
"I went to box gym at the BYC (Bundaberg Youth Club) and I kept going to every training for a fight coming up in Bundy. (BYC coach) Bob Butler wanted me to train for the fight and I trained and trained and trained but no one would fight me.
"My first fight was back in Toowoomba a year-and-a-half ago and I won by TKO. I fought a guy 10kg heavier than me but I stopped him in the second round and I think the score was 22-2.
"I love boxing."
Attila said his son's potential was unlimited.
boxing championships junior student


text:
package org.rfcx.client_android.adapter;

import java.util.ArrayList;

import org.rfcx.client_android.R;
import org.rfcx.client_android.model.Event;

import android.content.Context;
import android.view.LayoutInflater;
import android.view.View;
import android.view.ViewGroup;
import android.widget.ArrayAdapter;

public class RankingAdapter extends ArrayAdapter<Event> {

	public RankingAdapter(Context context, int resource, ArrayList<Event> radios) {
		super(context, resource, radios);
	}

	@Override
	public View getView(int position, View convertView, ViewGroup parent) {

		LayoutInflater inflater = (LayoutInflater) this.getContext()
		        .getSystemService(Context.LAYOUT_INFLATER_SERVICE);

		View rowView = inflater.inflate(R.layout.adapter_radio_rankingitem, parent, false);

		Event radio = getItem(position);
		return rowView;
	}

	public void addAll(ArrayList<Event> radios) {
		for(int i=0; i<radios.size(); i++) {
			insert(radios.get(i), getCount());
		}
	}
}

redpajama_set_name: RedPajamaGithub


text:
Hundreds arrested in Tunisia protests - Daily News Egypt
Politics Hundreds arrested in Tunisia protests
Hundreds arrested in Tunisia protests
Protests began last week ahead of seven-year Arab Spring anniversary
Daily News Egypt January 13, 2018 Be the first to comment
Tunisian police arrested another 150 people, including some local opposition leaders on Friday, as protests against price and tax rises continue to grow in intensity and numbers.
The latest arrests bring the total number of people detained to nearly 800, raising concerns that people are being arrested arbitrarily, according to several human rights organisations.
"The protests have declined and there was no damage, but last night the police arrested 150 people involved in rioting during the past few days, bringing the total number of detainees to 778," Interior Ministry spokesperson Khelifa Chibani told media outlet Deutsch Welle.
Sixteen "Islamist extremists" were among those arrested, he said.
Clashes earlier in the week were more violent. Dozens of government buildings were set alight and at least one protester was killed, prompting the government to deploy the army to several cities and towns.
The United Nations has called on the government to refrain from arresting people arbitrarily.
The protests began Monday, ahead of the seven-year anniversary of the Arab Spring, the pro-democracy uprising that began in Tunisia on 14 January 2011 which then began a wave of anti-government protests in several Arab countries.
Waving yellow cards, protesters marched toward administrative offices in the capital Tunis on Friday, demanding the government reverse austerity measures implemented at the start of the year.
Human rights organisation Amnesty International has accused Tunisian authorities of using "increasingly heavy-handed methods to disperse rallies and subsequently arrest protesters" during the unrest.
"Tunisian security forces must refrain from using excessive force, and end their use of intimidation tactics against peaceful demonstrators," Amnesty said.
Topics: anniversary Arab Spring protest Tunisia
https://wwww.dailynewssegypt.com/2018/01/13/hundreds-arrested-tunisia-protests/
Protests in Tunisia commemorating Arab Spring uprising continue
Post-Saleh guerrilla conflicts leave scores of civilians dead
20 companies provide insurance to Egyptians abroad
An inadequate order of alliances
Swiss government lifts freeze on Egyptian assets, keeps Tunisian, Ukrainian assets
Egypt's Investments Gatekeeper
We may not attend GCC summit unless Qatar changes its position: Bahraini FM
January 13, 2018 Breaking News


text:
Великі Мошки — село в Україні, в Овруцькій міській територіальній громаді Коростенського району Житомирської області. Населення становить 227 осіб.

Історія
У 1906 році — Мошки, село Гладковицької волості Овруцького повіту Волинської губернії. Відстань від повітового міста 8 верст, від волості 10. Дворів 162, мешканців 926.

У 1923—54 роках — адміністративний центр Великомошківської сільської ради Овруцького району Житомирської області.

До 13 квітня 2017 року село підпорядковувалося Раківщинській сільській раді Овруцького району Житомирської області.

Відомі уродженці
 Стоцький Микола Вікторович (1968—2015) — український військовик, прапорщик, розвідник 8 роти 92-ї окремої механізованої бригади. Кавалер ордена «За мужність» III ступеня.

Примітки

Джерела
 Список населених місць  Волинскої губернії. —  Житомир: Волинська губернська типографія, 1906. —- 219 с.

Посилання
 Погода в селі Великі Мошки

Села Житомирської області

redpajama_set_name: RedPajamaWikipedia


A friend of mine is in the process of doing a routine purge of his liquor cabinet, and I was lucky enough to be around when he was trying to find a new home for some of his bottles. Among the collection was a bottle of Old Forester Statesman, a label that I knew less from its renowned history as a good spirit and more for its prominence in a certain movie franchise.
Old Forester is a bourbon that deserves the name more than any other. The oldest bourbon in continuous production, it was first sold in 1870 (the first bourbon to be sold exclusively in a sealed bottle) and it continued production through prohibition as one of only 10 brands authorized for medicinal production.
Founded by a former pharmaceutical salesman named George Garvin Brown, the original version of Old Forester was sold to pharmacies as a medicinal product. Named after Dr. William Forrester (originally bottled with the double "r" as well) who endorsed its consumption, it is said that the second "r" was dropped to avoid the appearance of a conflict of interest with the doctor.
The original Old Forester bourbon was a mixture of spirits distilled by other distilleries in the Kentucky area, but starting in 1902 they purchased Matingly's distillery in Saint Mary, Kentucky to be the sole source.
While the company went through a series of mergers and acquisitions over the years and is currently a publicly traded company, the original Brown family still owns over 70% of the shares of the company and de facto control of the company.
Old Forester was the company's best selling product prior to prohibition and continued production through that dark time, but once prohibition ended one of the company's other brands, Jack Daniels, took the lead and remains the most popular whiskey in the world to this day. Other spirits produced by the Brown-Forman company (as it is known today) include Woodford Reserve, Early Times, and Herradura Tequila.
In 2017, 20th Century Fox released a sequel to their popular Kingsman film titled "Kingsman: The Golden Circle." The plot of the movie (spoiler alert, I guess) revolved around a group of secret agents within the United States called the Statesman who operated out of a bourbon distillery in Kentucky. As part of the marketing push for the movie, Old Forester partnered with Fox to produce a special bottling of their spirit with the Statesman brand.
According to the marketing materials, this is simply a selection of standard Old Forester bourbon that was selected from the hottest part of the warehouse. As such the grain bill is the typical 72% corn, 18% rye, and 10% malted barley — the same mixture used for Woodford Reserve. The spirit is bottled at the same alcohol content as their Old Forester Birthday Bourbon spirit, 95 proof instead of the typical 86 proof. Although the details of the aging on this spirit aren't listed on the bottle, some other experts state that the spirit is aged between 4 and 6 years.
The most remarkable thing about this spirit is that it is still available on store shelves. I'm not sure whether that's proof that the spirit is doing so well that they still make it — or so poorly that the original bottles are still hanging around, but it sure seems odd to see a specialty spirit created for a movie that came out two years ago still available for sale.
The bottle is a classic liquor bottle design, which I appreciate and like very much. It looks good on the shelf and feels good when pouring.
The label itself uses a more standard design for the Old Forester logo above a stylized Statesman logo, all without the typical white background. It's a good design, mixing the well known brand with a distinctive style that lets you know this is something different.
The thick bottomed bottle is topped with a cork and a wood stopper.
The spirit is a wonderful dark amber color that seems luxurious and deep. It sure looks great in the bottle and in the glass. There is a strong smell of caramel and vanilla, traditional bourbon flavors that you'd expect from a well aged spirit.
Such a shame that none of those flavors come through very well in the tasting.
The first thing you'll notice on sipping the spirit is that it's a little lighter in weight than you would expect from a 95 proof (47.5% ABV) alcohol. That's on the higher side of the spectrum and should provide a nice viscosity to the liquor but instead it's remarkably light.
As the liquid flows over your tongue, you won't notice much. At first there's just a general warmth, followed by a taste that can best be described as licking an oak barrel. On the finish there's a bitterness to the taste that attacks the back of your tongue and wipes out any remaining flavor that might have existed.
Things are a little better here. The ice and the colder temperature counteracts the bitterness in the liquor.
However, despite the reduced bitterness there's still not much flavor. Instead of a nice complex mixture of those caramel and vanilla notes that were in the aroma there's still just that "like licking the decking of the USS Constitution" taste.
It's not terrible. But it isn't very complex either.
Here's where the spirit starts to make sense.
While the oak-y flavor isn't very complex, it definitely is bold. And once you add some orange bitters and an orange peel to the mix, those elements add the necessary depth to make a drinkable cocktail. It isn't something that will blow me away, but I wouldn't turn it down at a bar.
Quick tip here: the sugar is what will ultimately eliminate the last of the bitterness from the spirit. With just the bitters and the orange peel alone there's still that cheek sucking tannin at the end of the taste, a little bit of sugar and it's gone like a magic trick.
If you're making this into a mixed drink, a Kentucky mule might be your best bet. Not only does the sugar in the ginger beer counteract the tannin in the whiskey, but the ginger does a great job balancing with the oak flavor in the spirit.
It's not great, but it's not terrible. If my options were this or Jack Daniels I'd probably pick this due to the way it mixes well in an old fashioned. That said. I'm concerned about the longevity of this label considering the now outdated movie tie in, so if this piques your interest you should probably grab a bottle while you can. For me, I appreciate the uniqueness of the marketing campaign.
It's not a fantastic spirit, but to me there's some value in the rarity of the bottle and the oddity of how it came into existence.


She's not your average yoga teacher. Gretchen is a slightly unconventional, totally real ERYT-200 hour teacher, trained by Marni Task, + a constantly curious student of life who has built a following by teaching directly from her heart. No fronts. No facades. Through laughter or tears she delivers straight-up, damn good yoga experiences to her students.
On top of teaching studio classes & workshops, Gretchen is passionate about hosting local yoga events that incorporate sweating & socializing to build up connections within her community.
I believe yoga can do you a world of good. Whether you prefer a power practice or regrounding with a soulful slow flow, the mental, physical, emotional, & spiritual benefits of being on your mat & in community are extraordinary.
I believe that when you feel good, (you know, that feet on the ground, head in the clouds kind of good) you start living it out in every moment, of all your days. That goodness, resulting from your choice to live fully, from a place of intention, with fearless authenticity, extends to the greater collective of beings that make up your community. When you do good for yourself, you're doing good for others.
I believe YOU can change the world. Join me on this journey to do good, to create positive change within ourselves & our community.
Action | Yep. I embrace the totally radical notion that YOU can create a life you love every minute of living. But, you've got to stop waiting around. There is no magic potion. It requires YOUR active, deliberate, & willful participation in every moment, of every day. If you want things to change in your life & in your world, don't wait. Do good.
Authenticity | I keep it real, real. No matter where you are on this journey called life, I make sure my message & movement is accessible & applicable to your everyday life. I take traditional yogic texts & make the messages modern. I invoke the energy of Kali Ma & bow down to Queen Bey, all in one class. As a teacher + student of life, I promise to always share honest, humble learnings from personal experiences, no pretenses.


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Gadget Tendency
This is how the flagship Samsung Galaxy S21 Ultra shoots. Sample photos in different conditions
Henry Brown
The well-known network informant under the nickname Ice Universe, who often shares exclusive information about new products in the mobile industry, has published high-quality photos taken with the camera of the flagship smartphone Samsung Galaxy S21 Ultra.
The pictures were taken by a professional photographer who confirmed that the Samsung Galaxy S21 Ultra camera performs excellent results at different focal lengths.
Earlier, the same insider confirmed that the extended dynamic range works better on the Samsung Galaxy S21 Ultra than on its predecessor, and the main camera lens has a wider angle of view.
We could also see how the 100x zoom works.
Xiaomi 11, Xiaomi 10S, Redmi K40, Redmi Note 12, Redmi Note 10 Pro and 19 more Xiaomi and Redmi phones will receive the final MIUI 14 by the end of March. Full list of models
Xiaomi today published a list of phone models that make up the second wave of the MIUI 14 update. The list of devices of the first wave, we recall, was presented after the premiere of Xiaomi 13 and Xiaomi 13 Pro, all devices from this list have already received the final MIUI 14 in China. And now the list of devices of the second wave has been published.
Xiaomi:
mix 4;
12X;
11 Ultra;
11 Pro;
eleven;
11 Lite;
10S;
Civi 1S;
Civie 2.
Redmi:
K40 Pro;
K40S;
K40;
Note 12 Pro;
Note 12 Pro+;
Note 12 5G;
Note 12 Explorer Edition;
Note 12 Trendy Edition;
Note 11T Pro;
Note 11T Pro+;
Note 11E;
K40 Gaming Enhanced Edition;
Note11 Pro+.
All these phones will receive the final MIUI 14 before the end of March this year. Moreover, in some cases, the firmware will be built on Android 13 (for fresh models like Redmi Note 12 Pro), in some cases, based on Android 12 (Xiaomi 10S). You also need to understand that the indicated period is valid for China, in other countries the final MIUI 14 will be released later.
As for tablets, the release of the final MIUI 14 for Xiaomi Pad 5 Pro 12.4, Xiaomi Pad 5 Pro 5G, Xiaomi Pad 5 Pro, Xiaomi Pad 5 and Redmi Pad is expected in early April.
Fujifilm is preparing a new camera line X. Fujifilm X-S20 is expected to premiere in April
Jeff Tucker
According to Fujirumors thematic resource, Fujifilm is working on a new X-series camera – X-S20. Moreover, the work is at the final stage, and the premiere may take place as early as April this year at an official Fujifilm event.
Technical details about the Fujifilm X-S20, but it should be better than the X-S10 released in October 2020. It, recall, is equipped with a 26.1 megapixel X-TransTM CMOS 4 sensor, an X-Processor 4 image processor and a built-in 5-axis stabilization system (In-body image stabilization, IBIS). The Fujifilm X-S10 is made in a magnesium alloy body and supports 4K video recording at 30 fps.
The lack of 5G is not a hindrance. Huawei is the only Chinese company that managed to increase sales of phones in the home market in Q4 2022
Analysts at Counterpoint Research have published data on the Chinese phone market for the fourth quarter of 2022.
Only two companies, Huawei and Apple, increased their market share in China in the last quarter of 2022. Moreover, if in the case of Apple, the growth is relatively small, by 0.7%, then Huawei shot by 2.5%. Huawei ranks 6th in the Chinese market, but the gap with Xiaomi has narrowed.
As for the growth in sales of phones, only Huawei has it – the company managed to increase sales by 15% in the last quarter. The rest have a minus, and Realme has a significant one.
Apparently, Huawei's success in the last quarter is due to the Mate 50 line – these phones sell very well in China even despite the lack of an integrated 5G modem.
Four-wheel drive, 7 seats, 6.7 liter diesel engine and a ladder to climb onto the roof. New photos of the gigantic SUV Dongfeng Warrior M20
The Carnewschina resource has published new photos of the Dongfeng Warrior M20 SUV – it has not yet been officially...
Xiaomi today published a list of phone models that make up the second wave of the MIUI 14 update. The...
According to Fujirumors thematic resource, Fujifilm is working on a new X-series camera – X-S20. Moreover, the work is at...
150 hp diesel engine, 6-speed "mechanics" and all-wheel drive for $14,500. Sales of pickup JAC T6 2023 started in China
According to the Autohome resource, sales of the 2023 JAC T6 pickup truck have started in China. The car is...
Phones6 days ago
This is Colaphone. The first image of Coca-Cola's branded smartphone
Is history repeating itself with the iPhone 9? Anniversary Apple Watch X will replace Apple Watch Series 9 this year
Laptops6 days ago
Top laptops Samsung Galaxy Book 3 Pro and Book 3 Ultra declassified before the announcement: up to Intel Core i9-13900H, 32 GB of RAM and Nvidia RTX 4070
Samsung will pay royalties to Nokia for several years. The companies signed a license agreement
© 2023 Gadget Tendency. All Rights Reserved


Silly asteroid, rings are for Saturn! Not anymore. Astronomers have discovered an asteroid hosting a ring system of its very own.
A faraway asteroid named Chariklo is traveling through space with two unusual companions: a couple of dense, narrow rings. The discovery came as quite a surprise. Multiple sites around South America, including the European Southern Observatory's La Silla Observatory in Chile, observed the extraordinary feature.
"This is the smallest object by far found to have rings, and only the fifth body in the Solar System -- after the much larger planets Jupiter, Saturn, Uranus, and Neptune -- to have this feature," the European Southern Observatory noted in a release about the find. There is no definitive answer as to how the rings got there, but scientists speculate they may have been created from a debris field caused by an impact, along with ice.
Icy Chariklo orbits the sun between Saturn and Uranus. One of its rings is just over four miles wide, while the other ring is just under two miles wide, making them quite slim. The rings were found during a routine observation as the asteroid passed in front of a star.
"We weren't looking for a ring and didn't think small bodies like Chariklo had them at all, so the discovery -- and the amazing amount of detail we saw in the system -- came as a complete surprise!" says Felipe Braga-Ribas, the lead author of a paper on the find published in the journal Nature.
Chariklo is named for a mythological nypmh who was married to a centaur. The rings have been given their own nicknames, Oiapoque and Chuí, after two rivers located in Brazil. The presence of the rings may indicate the asteroid also has a small moon, or that the rings could eventually form into a moon. It's likely Chariklo isn't done surprising us yet.


Check out this awesome looking pedicure! The flowers on the toe nails are beautifully layout. Who wouldn't want their toes to look this great.
Cool Pedicure Nail Designs. Pedicure flower designs. Zebra pedicure designs. Pedicure design gallery. Toenail designs. Peticure designs.
checker flag nailart. pedicure nailart. Pinned by ?Tomo?


Each year FutureEverything proposes, develops and responds to particular themes and ideas. These themes are provocations, designed to open up a space for debate and practice, made tangible through art and design projects, and a 'festival as laboratory'. FutureEverything publications seeks to contribute to an international dialogue around these themes and ideas.


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Cycling Training And Fitness Aid Reviews
Aftershokz OpenMove headphones review
Sound transmitted via vibration, as per these AferShokz OpenMove headphones, is ideal for indoor cyclists and those who want to keep their ears open
A lightweight, sweat resistant set of headphones which allow you to enjoy audio without cutting off your connection to the outside world. Sounds outside of the audio were always clear, and the quality of music emitted was always good. The Bluetooth connection would drop out very briefly on occasion, but this wasn't a major concern. Our only quibbles were the fit around the back of the head and slightly odd feel of vibrations through the earpieces.
Ability to hear outside noise
Awkward fit
By Michelle Arthurs-Brennan published 2 November 20
Bone conduction headphones, like these Aftershokz OpenMove headphones, are designed to transmit sound to your auditory nerve via vibration - therefore leaving your ears open to outside noise. This makes them a valid option for cyclists who want to listen to music or podcasts when riding, whilst remaining aware of their surroundings.
Not everyone is comfortable with listening to music whilst cycling outside, but these headphones also have another use: because they don't sit in your ears, and are wireless, they're also less vulnerable to damage from sweat - which, as a regular visitor to the virtual worlds of Watopia and Sufferlandria, was my primary interest.
The OpenMove earphones are a relatively new launch from AferShokz, and they sit at a more entry-level price tag compared to the brand's other offerings (such as the AfterShokz Titanium headphones). However, they're far from basic.
Weighing in at 29g, the OpenMoves are lightweight and flexible, featuring curved ear hooks and lightly magnetic earpieces which snap to meet each other when out of use.
Magnetic earpieces snap together out of use
The loop that sits at the back of the head is made from a malleable plastic, and there is an on/off button on the right hand side as well as volume controls and a charging port which takes a USB C cable. Charing takes two hours. The system is sweat resistant, though you're advised to dry them out before charging if you do get them 'moist'.
These headphones have three modes - standard, vocal booster and ear plug mode.
The first is what you'd expect to use most of the time, using Aftershokz's 7th generation of bone conduction tech to deliver sound. Select vocal booster and higher frequencies enjoy a boost, whilst the 'ear plug' mode is for use alongside supplied foam ear plugs (these are very basic ear plugs you could buy in a pharmacy and replace easily if you have a preferred pair), lowering the volume and bass and effectively returning the sound to a standard in-ear experience. I used the standard mode most of the time.
The headphones use a Bluetooth 5.0 chip, which connects to the audio feeding device. In my case, I mainly hooked them up to my phone - usually featuring playlists from Spotify that allow me to indulge my inner punk and pretend I'm still 16-years-old whilst pounding pavements or pedals. The paired device will stay connected up to 10 metres. The connection was always quick. I did find the sound broke up briefly during some uses - leaving the vocalist omitting staccato oddities into my ears - but this was occasional and always very short-lived (sub 20 seconds).
The battery lasts a claimed six hours of continuous use (10 days on standby), and I never found myself disappointed with the duration between charges. I did manage to run them out accidentally several times - because I'd end the session by closing down the app in use (eg, Spotify), remove the headphones and fail to press the on/off button. Typically I'd realise a few hours later when I could faintly hear them emitting the sound of a phone call or random Facebook cat video at the foot of the stairs where I'd discarded them.
7th generation bone conducting tech provides the sound
The actual audio was always good - always full-bodied and never tinny. I did find that I could sometimes hear it having removed the headphones, more so than with in-ear options, so it is worth testing this to avoid being that anti-social person playing your tunes to the (albeit socially distant) train carriage. Regardless, I was impressed that I could always hear what was going on around me, walking into town to the tune of the raucous Girl Anachronism by my favourite punk cabaret band, for example, I could hear every car from a reasonable distance. This is notable because other bone-conducting headphones tested by the Cycling Weekly team have been less successful - with outside noises not audible over the sound of the music, pretty much defeating the object.
Training indoors the earphones stayed in place despite my sweating profusely, and I also used these for gym sessions without them budging. I'd never be able to complete kettlebell swings in my back garden using wired or in-ear headphones, and I also wouldn't want to force the neighbours to listen to an hour of industrial metal - so these provided a perfect solution.
There's always a "but", and for me it was the fit of the headphones and the feel of the vibrations. I have quite a small head, and the 'loop' behind my neck was quite long. It's not adjustable, leaving a strange overhang. This was particularly irritating on the occasion that I decided to go for a walk wearing my prescription glasses, a winter hat, and the headphones. I kept having to adjust them to keep it all in place. That said, I've never had much luck with in-ear headphones either, and at least in this case I was never at risk of losing the earbud.
The vibration is part and parcel of using bone-conducting headphones. However, I never fully got used to it. This was more noticeable on some tracks than others, the bass booms during the intro to 'London Calling' by The Clash, for example, were particularly disconcerting. If I used the headphones for over an hour, I'd get a nagging niggle approaching the onset of a headache - so I'm not sure I'd want to use them for much longer. However, habitual users might be accustomed to this - and the bone-conducting tech does allow you to remain open to noises outside of your own audio world whilst eliminating the issue of sweat damage.
Tom Pidcock and Zoe Bäckstedt among British Cycling's cyclocross world championships contenders
Performance director looks to 'medal contenders across all categories' for some big results


If you have Health Insurance, Medical Insurance, or Dental Insurance coverage at work, this may be fine, but it pays to check. If you are paying for your own group Health insurance or Medical insurance, let Washington and Co Insurance Agency in Cleveland, OH, 216-691-9227 review your policy. Remember, you may leave that job someday. Will your Health Insurance, Medical Insurance or Dental Insurance coverage follow? Not likely. We also write Group Health Insurance or Group Medical Insurance.
What types of Health Insurance or Medical Insurance plans are available?
The two basic Health insurance or Medical Insurance plans types that you should be aware of are Guaranteed Issue versus Major Medical. (Guaranteed Issue is often called "Mini-Med", or "Defined Benefit") In case of illness, a Guaranteed Issue plan will pay their share of the cost usually upon receipt of the bill, from you. This means that you may have to pay up-front costs, and get reimbursed later-on. A guaranteed issue plan usually has no deductibles. It usually covers pre-existing conditions after a period of 12 months. Guaranteed Issue plans pay only specified amounts for specified procedures. For minor procedures, these plans are often quite cost-effective. However, for major illness, there is nothing to replace a Major Medical plan.
For a personal quote of your Health Insurance, Medical Insurance or Dental Insurance, contact Washington and Co Insurance Agency, Cleveland, Ohio, 216-691-9227.


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Characterization of photodamage in coherent anti-Stokes Raman scattering microscopy
Yan Fu, Haifeng Wang, Riyi Shi, and Ji-Xin Cheng
Yan Fu,1 Haifeng Wang,1 Riyi Shi,1,3 and Ji-Xin Cheng1,2
1Weldon School of Biomedical Engineering,
2Department of Chemistry,
3Department of Basic Medical Sciences, Institute for Applied Neurology, and Center for Paralysis Research, Purdue University, West Lafayette, IN 47907 USA
Y Fu
H Wang
R Shi
J Cheng
Yan Fu, Haifeng Wang, Riyi Shi, and Ji-Xin Cheng, "Characterization of photodamage in coherent anti-Stokes Raman scattering microscopy," Opt. Express 14, 3942-3951 (2006)
Confocal laser scanning microscopy
Four wave mixing
High power lasers
Laser beams
Laser energy
Scanning microscopy (180.5810)
Ultrafast nonlinear optics (190.7110)
Damage (350.1820)
Original Manuscript: January 18, 2006
Virtual Journal for Biomedical Optics Vol. 1, Iss. 6
We report a mechanistic analysis of photodamage in coherent anti-Stokes Raman scattering (CARS) microscopy. Photodamage to the myelin sheath in spinal tissues is induced by using the point scan mode and is featured by myelin splitting and shockwaves with broadband emission. Our measurement of photodamage rate versus the excitation power reveals that both linear and nonlinear mechanisms are involved. Moreover, we show that vibrational absorption induced by coherent Raman processes significantly contributes to the nonlinear damage at high peak powers. For CARS imaging of cultured cells, the photodamage is characterized by plasma membrane blebbing and is dominated by a second order mechanism. Our study suggests that for dense samples such as the myelin sheath, CARS imaging induced photodamage can be minimized by using laser beams with relatively long near IR wavelengths and a repetition rate of a few MHz. For less dense samples such as cultured cells, laser pulses of higher repetition rates are preferred.
©2006 Optical Society of America
Ex vivo and in vivo imaging of myelin fibers in mouse brain by coherent anti-Stokes Raman scattering microscopy
Yan Fu, T. Brandon Huff, Han-Wei Wang, Haifeng Wang, and Ji-Xin Cheng
Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy
Ji-Xin Cheng, Andreas Volkmer, and X. Sunney Xie
J. Opt. Soc. Am. B 19(6) 1363-1375 (2002)
Quantitative myelin imaging with coherent anti-Stokes Raman scattering microscopy: alleviating the excitation polarization dependence with circularly polarized laser beams
E. Bélanger, S. Bégin, S. Laffray, Y. De Koninck, R. Vallée, and D. Côté
Numerical study of effects of light polarization, scatterer sizes and orientations on near-field coherent anti-Stokes Raman scattering microscopy
Jian Lin, Haifeng Wang, Wei Zheng, Fake Lu, Colin Sheppard, and Huang Zhiwei
Polarization coherent anti-Stokes Raman scattering microscopy
Ji-Xin Cheng, Lewis D. Book, and X. Sunney Xie
Opt. Lett. 26(17) 1341-1343 (2001)
W. Denk, J. H. Strickler, and W. W. Webb, "Two-Photon Laser Scanning Fluorescence Microscopy," Science 248, 73–76 (1990).
C. Xu, W. Zipfel, J. B. Shear, R. M. Williams, and W. W. Webb, "Multiphoton fluorescence excitation: new spectral windows for biological nonlinear microscopy," Proc. Natl. Acad. Sci. USA 93, 10763–10768 (1996).
L. Moreaux, O. Sandre, and J. Mertz, "Membrane imaging by second-harmonic generation microscopy," J. Opt. Soc. Am. B 17, 1685–1694 (2000).
P. J. Campagnola and L. M. Loew, "Second-harmonic imaging microscopy for visualizing biomolecular arrays in cells, tissues and organisms," Nat. Biotech. 21, 1356–1360 (2003).
J. X. Cheng and X. S. Xie, "Coherent anti-Stokes Raman scattering microscopy: instrumentation, theory, and applications," J. Phys. Chem. B 108, 827–840 (2004).
M. D. Duncan, J. Reintjes, and T. J. Manuccia, "Scanning Coherent Anti-Stokes Raman Microscope," Opt. Lett. 7, 350–352 (1982).
A. Zumbusch, G. R. Holtom, and X. S. Xie, "Three-dimensional vibrational imaging by coherent anti-Stokes Raman scattering," Phys. Rev. Lett. 82, 4142–4145 (1999).
J. X. Cheng, A. Volkmer, L. D. Book, and X. S. Xie, "An epi-detected coherent anti-Stokes Raman scattering (E-CARS) microscope with high spectral resolution and high sensitivity," J. Phys. Chem. B 105, 1277–1280 (2001).
A. Volkmer, J. X. Cheng, and X. S. Xie, "Vibrational imaging with high sensitivity via epi-detected coherent anti-Stokes Raman scattering microscopy," Phys. Rev. Lett. 87, 023901 (2001).
G. W. H. Wurpel, J. M. Schins, and M. Müller, "Chemical specificity in three-dimensional imaging with multiplex coherent anti-Stokes Raman scattering microscopy," Opt. Lett. 27, 1093–1095 (2002).
J. X. Cheng, A. Volkmer, and X. S. Xie, "Theoretical and experimental characterization of coherent anti-Stokes Raman scattering microscopy," J. Opt. Soc. Am. B 19, 1363–1375 (2002).
N. Dudovich, D. Oron, and Y. Silberberg, "Single-pulse coherently controlled nonlinear Raman spectroscopy and microscopy," Nature 418, 512–514 (2002).
C. L. Evans, E. O. Potma, and X. S. Xie, "Coherent anti-Stokes Raman scattering spectral interferometry: determination of the real and imaginary components of nonlinear susceptibility χ(3) for vibrational microscopy," Opt. Lett. 29, 2923–2925 (2004).
K. P. Knutsen, J. C. Johnson, A. E. Miller, P. B. Petersen, and R. J. Saykally, "High spectral resolution multiplex CARS spectroscopy using chirped pulses," Chem. Phys. Lett. 387, 436–441 (2004).
T. Ichimura, N. Hayazawa, M. Hashimoto, Y. Inouye, and S. Kawata, "Tip-enhanced coherent anti-Stokes Raman scattering for vibrational nanoimaging," Phys. Rev. Lett. 92, 220801 (2004).
J. S. Bredfeldt, C. Vinegoni, D. L. Marks, and S. A. Boppart, "Molecular sensitivity optical coherence tomography," Opt. Lett. 30, 495–497 (2005).
P. D. Maker and R. W. Terhune, "Study of Optical effects Due to an Induced Polarization Third Order in the Electric Field Strength," Phys. Rev. 137, A801–818 (1965).
Y. R. Shen, The Principles of Nonlinear Optics (John Wiley and Sons Inc., New York,1984).
L. Li, H. Wang, and J. X. Cheng, "Quantitative coherent anti-Stokes Raman scattering imaging of lipid distribution in co-existing domains," Biophys. J. 89, 3480–3490 (2005).
G. W. H. Wurpel, H. A. Rinia, and M. Müller, "Imaging orientational order and lipid density in multilamellar vesicles with multiplex CARS microscopy," J. Microsc. 218, 37–45 (2005).
E. O. Potma and X. S. Xie, "Direct visualization of lipid phase segregation in single lipid bilayers with coherent anti-Stokes Raman scattering microscopy," Chem. Phys. Chem. 6, 77–79 (2005).
X. Nan, J. X. Cheng, and X. S. Xie, "Vibrational imaging of lipid droplets in live fibroblast cells using coherent anti-Stokes Raman microscopy," J. Lipid Res. 40, 2202–2208 (2003).
C. L. Evans, E. O. Potma, M. Puoris'haag, D. Côté, C. P. Lin, and X. S. Xie, "Chemical imaging of tissue in vivo with video-rate coherent anti-Stokes Raman scattering microscopy," Proc. Natl. Acad. Sci. USA 102, 16807–16812 (2005).
J. X. Cheng, S. Pautot, D. A. Weitz, and X. S. Xie, "Ordering of water molecules between phospholipid bilayers visualized by coherent anti-Stokes Raman scattering microscopy," Proc. Natl. Acad. Sci. USA 100, 9826–9830 (2003).
E. O. Potma, W. P. D. Boeij, P. J. M. v. Haastert, and D. A. Wiersma, "Real-time visualization of intracellular hydrodynamics in single living cells," Proc. Natl. Acad. Sci. USA 98, 1577–1582 (2001).
A. P. Kennedy, J. Sutcliffe, and J. X. Cheng, "Molecular composition and orientation of myelin figures characterized by coherent anti-Stokes Raman scattering microscopy," Langmuir 21, 6478–6486 (2005).
H. Wang, Y. Fu, P. Zickmund, R. Shi, and J. X. Cheng, "Coherent anti-Stokes Raman scattering imaging of live spinal tissues," Biophys. J. 89, 581–591 (2005).
A. Vogel, J. Noack, G. Huettmann, and G. Paltauf, "Femtosecond-laser-produced low-density plasmas in transparent biological media: a tool for the creation of chemical, thermal, and thermomechanical effects below the optical breakdown threshold," Proc. SPIE 4633A, 1–15 (2002).
K. König, "Laser tweezers and multiphoton microscopes in life sciences," Histochem. Cell Biol. 114, 79–92 (2000).
A. Hopt and E. Neher, "Highly nonlinear photodamage in two-photon fluorescence microscopy," Biophys. J. 80, 2029–2036 (2001).
K. König, T. W. Becker, P. Fischer, I. Riemann, and K.-J. Halbhuber, "Pulse-length dependence of cellular response to intense near-infrared laser pulses in multiphoton microscopes," Opt. Lett. 24, 113–115 (1999).
H. J. Koester, D. Baur, R. Uhl, and S. W. Hell, "Ca2+ fluorescence imaging with pico- and femtosecond two-photon excitation: signal and photodamge," Biophys. J. 77, 2226–2236 (1999).
J. S. Gomez, "Coherent Raman Spectroscopy," in Modern Techniques in Raman SpectroscopJ. J. Laserna, editor. (John Wiley & Sons Inc., New York,1996).
P. Morell and R. H. Quarles, "Myelin formation, structure, and biochemistry," in Basic Neurochemistry: Molecular, Cellular, and Medical Aspects, G. J. Siegel, B. W. Agranoff, R. W. Alberts, and P. B. Molinoff, eds. (Lippincott Williams & Wilkins, Philadelphia,1999).
P. N. Prasad, Introduction to biophotonics. (Wiley Interscience, Hoboken, NJ,2003), pp. 168–175.
J. Diels and W. Rudolph, "Generation of extreme wavelengths," in Ultrashort laser pulse phenomena: fundamentals, techniques, and applications on a femtosecond time scale. (Academic Press, San Diego,1996), pp. 472–475.
H. R. Griem, "Optical radiation," in Plasma physics in theory and application, W. B. Kunkel, editor. (McGraw-Hill, Inc., New York, 1966), pp. 278–280.
K. C. Neuman, E. H. Chadd, G. F. Liou, K. Bergman, and S. M. Block, "Characterization of photodamage to Escherichia coli in optical traps," Biophys. J. 77, 2856–2863 (1999).
B. R. Masters, P. T. C. So, C. Buehler, N. Barry, J. D. Sutin, W. W. Mantulin, and E. Gratton, "Mitigating thermal mechanical damage potential during two-photon dermal imaging," J. Biomed. Opt. 9, 1265–1270 (2004).
Y. Liu, G. J. Sonek, M. W. Berns, and B. J. Tromberg, "Physiological monitoring of optically trapped cells: assessing the effects of confinement by 1064-nm laser tweezers using microfluorometry," Biophys. J. 71, 2158–2167 (1996).
H. Wang, Y. Fu, and J. X. Cheng, "Light-matter energy exchange in coherent Raman microscopy," Phys. Rev. A, submitted (2005).
K. König, H. Liang, M. W. Berns, and B. J. Tromberg, "Cell damage in near-infrared multimode optical traps as a result of multiphoton absorption," Opt. Lett. 21, 1090–1092 (1996).
M. L. Cunningham, J. S. Johnson, S. M. Giovanazzi, and M. J. Peak, "Photosensitized production of superoxide anion by monochromatic (290–405 nm) ultraviolet irradiation of NADH and NADPH coenzymes," Photochem. Photobiol. 42, 125–128 (1985).
Agranoff, B. W.
Alberts, R. W.
Barry, N.
Baur, D.
Becker, T. W.
Bergman, K.
Berns, M. W.
Block, S. M.
Boeij, W. P. D.
Book, L. D.
Boppart, S. A.
Bredfeldt, J. S.
Buehler, C.
Campagnola, P. J.
Chadd, E. H.
Cheng, J. X.
Côté, D.
Cunningham, M. L.
Denk, W.
Diels, J.
Dudovich, N.
Duncan, M. D.
Evans, C. L.
Fischer, P.
Fu, Y.
Giovanazzi, S. M.
Gomez, J. S.
Gratton, E.
Griem, H. R.
Haastert, P. J. M. v.
Halbhuber, K.-J.
Hashimoto, M.
Hayazawa, N.
Hell, S. W.
Holtom, G. R.
Hopt, A.
Huettmann, G.
Ichimura, T.
Inouye, Y.
Johnson, J. C.
Johnson, J. S.
Kawata, S.
Kennedy, A. P.
Knutsen, K. P.
Koester, H. J.
König, K.
Kunkel, W. B.
Laserna, J. J.
Li, L.
Liang, H.
Lin, C. P.
Liou, G. F.
Loew, L. M.
Maker, P. D.
Mantulin, W. W.
Manuccia, T. J.
Marks, D. L.
Masters, B. R.
Mertz, J.
Miller, A. E.
Molinoff, P. B.
Moreaux, L.
Morell, P.
Müller, M.
Nan, X.
Neher, E.
Neuman, K. C.
Noack, J.
Oron, D.
Paltauf, G.
Pautot, S.
Peak, M. J.
Petersen, P. B.
Potma, E. O.
Prasad, P. N.
Puoris'haag, M.
Quarles, R. H.
Reintjes, J.
Riemann, I.
Rinia, H. A.
Rudolph, W.
Sandre, O.
Saykally, R. J.
Schins, J. M.
Shear, J. B.
Shen, Y. R.
Shi, R.
Siegel, G. J.
Silberberg, Y.
So, P. T. C.
Sonek, G. J.
Strickler, J. H.
Sutcliffe, J.
Sutin, J. D.
Terhune, R. W.
Tromberg, B. J.
Uhl, R.
Vinegoni, C.
Vogel, A.
Volkmer, A.
Wang, H.
Webb, W. W.
Weitz, D. A.
Wiersma, D. A.
Williams, R. M.
Wurpel, G. W. H.
Xie, X. S.
Xu, C.
Zickmund, P.
Zipfel, W.
Zumbusch, A.
Biophys. J. (6)
Chem. Phys. Chem. (1)
Chem. Phys. Lett. (1)
Histochem. Cell Biol. (1)
J. Biomed. Opt. (1)
J. Lipid Res. (1)
J. Microsc. (1)
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Fig. 1. CARS images of myelin sheath in spinal tissue. (a) Normal myelin sheath wrapping five parallel axons labeled as "ax". The middle axon displays a node of Ranvier (NR). Bar = 10 μm. (b) A Schmidt-Lanterman incisure. Bar = 5 μm. The images in (a-b) were acquired with the peak pump and Stokes power of 323 W and 129 W, respectively. (c) E-CARS image of a damaged site acquired after x-y scanning for 22 s. (d) E-CARS and (e) F-CARS images of the same damaged site as in (c) acquired after x-y scanning for 25 s. The damage shown in (c-e) was induced with peak pump and Stokes power of 74 W and 60 W, respectively. f = 39 MHz. Bar = 5 μm for images (c-e).
Fig. 2. CARS images of single myelin sheath before and after photodamage induced by point scanning. The x-y imaging and point scanning were carried out at the same condition. (a-b) results with high peak power of the pump (308 W) and Stokes (149 W) beams. f = 0.65 MHz. (e) Intensity trace of point scanning at the position indicated by the red star in (a). (c-d) results with low peak power of the pump (38 W) and Stokes (19 W) beams. f = 15.6 MHz. (f) Intensity trace of point scanning at the position indicated by the red cross in (c). For all images, bar = 5 μm.
Fig. 3. Dependence of photodamage rate on the total excitation peak power on the sample. f = 3.9 MHz. The power ratio of pump to Stokes lasers was kept constant at 3.2. The peak power of the pump and Stokes beams were adjusted from 74 W to 277 W and from 23 W to 86 W, respectively.
Fig. 4. Dependence of photodamage rate on the Raman shift. The pump wavelength was fixed at 701 nm and the Stokes beam was tuned to generate different Raman shifts. (a) Significant dependence observed with high peak powers of pump (338 W) and Stokes (203 W) beams at f = 1.3 MHz. (b) No dependence observed at low peak powers of pump (32 W) and Stokes (19 W) beams at f = 15.6 MHz.
Fig. 5. (a) Dependence of photodamage rate on the pump to Stokes power ratio under the condition of constant CARS signal. f = 3.9 MHz. (b) Dependence of photodamage rate on the repetition rate under the condition of constant CARS signal. The power ratio of pump to Stokes was fixed at 2. f was varied from 0.65 to 39 MHz. To maintain the same CARS signal at different repetition rates, the pump peak power was changed from 286 W to 52 W and the Stokes peak power from 143 W to 26 W accordingly.
Fig. 6. Photodamage in CARS imaging of live KB cells. (a) CARS image of a KB cell under normal conditions. (b) CARS image of the same KB cell after 3min of scanning with the pump peak power 373W and Stokes peak power 101W. Bar = 10 μm. (c) Dependence of photodamage rate on the total excitation peak power. f = 7.8 MHz. The power ratio of pump to Stokes lasers was kept at 3.8. The peak power of the pump and Stokes beams were adjusted from 138.4 W to 373 W and from 36 W to 101 W, respectively.


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