I wanted to include this story from The New York Times last month, but it came to me late in the month and I didn't think there was room. It deserves room.
For her first appointment with Dr. Daniel Simon, Neelima Raval showed up with a rolling file cabinet full of documents. She had downloaded every word written by or about Dr. Paolo Zamboni, a vascular surgeon from Italy with a most unorthodox theory about MULTIPLE SCLEROSIS.
Dr. Zamboni believes that the disease, which damages the nervous system, may be caused by narrowed veins in the neck and chest that block the drainage of blood from the brain. He has reported in medical journals that opening those veins with the kind of balloons used to treat blocked heart arteries -- an experimental treatment he calls the "liberation procedure" -- can relieve symptoms.
The idea is a radical departure from the conventional belief that multiple sclerosis is caused by a malfunctioning immune system and inflammation.
The new theory has taken off on the Internet, inspiring hope among patients, interest from some researchers and scorn from others. Supporters consider it an outside-the-box idea that could transform the treatment of the disease. Critics call it an outlandish notion that will probably waste time and money, and may harm patients.
These critics warn that multiple sclerosis has unpredictable attacks and remissions that make it devilishly hard to know whether treatments are working -- leaving patients vulnerable to purported "cures" that do not work.
The controversy has exposed the deep frustration of many people with this incurable, disabling disease, who feel that research has let them down. It is a case study in the power of the Internet to inform and unite angry patients -- which may be a double-edged sword. Pressure from activists helped persuade the Multiple Sclerosis Society to pay for studies of Dr. Zamboni's theory, but the Internet buzz has also created an avid market for a therapy that is still unproved.
"It's eye-opening the way this group of patients has grabbed hold of the social-networking technology," said Dr. Simon, an interventional radiologist at JFK Medical Center in Edison, N.J. "They've taken this to a level I've not seen in other patients. Patients used to read an article or two. Now, they're actually seeing procedures on YouTube. Is this the future of medicine?"
Scientifically, the jury is out: Dr. Zamboni's hypothesis is being studied. It is not known whether narrowed veins are more common in people with multiple sclerosis than in others, and even if they are, whether the narrowings are a cause, or an effect, of the disease. There is no solid proof that opening the veins can help. There have been no studies with control groups -- the only way to find out whether a treatment works.
"In my view the evidence is quite scanty and the biological plausibility is low," said Dr. Stephen L. Hauser, the chairman of neurology at the University of California, San Francisco. Many neurologists agree. Dr. Hauser said there was much stronger evidence that they disease arose from genetic variations affecting the immune system.
But Dr. Adnan H. Siddiqui, part of a team at the University of Buffalo that has been studying Dr. Zamboni's theory, said that it made sense and that the data from Italy was encouraging. Still, he emphasized that more study was needed, and that patients should not be treated until the research was done.
Despite the lack of proof, many patients are captivated by the idea that multiple sclerosis might turn out to be a vascular disease. They want to believe it can be fixed with a relatively simple procedure, and they want to be tested and treated. Now.
These patients say they cannot afford to wait for research results because they will wind up in wheelchairs before the studies are done. Their only option so far has been a lifelong course of drugs with limited benefits and harsh side effects. To some, balloon treatment seems no riskier than those drugs.
Dr. Zamboni himself has said that the procedure should not yet be done outside of studies. He said in an interview that he was conducting research only and had turned down thousands of requests from people wanting to go to his clinic at the University of Ferrara.
But other doctors have set up shop. A clinic in India with a toll-free American phone number has an online advertisement for a "liberation package." Patients are posting testimonial videos and trading tips on clinics in Bulgaria, Poland and Jordan.
In the United States, where many hospitals forbid experimental treatments outside of studies, a "back alley" network of doctors willing to perform the procedure has begun to develop, said Dr. Salvatore J. A. Sclafani, chairman of radiology at Downstate Medical Center in Brooklyn. He said he knew of about a dozen. The doctors try to stay under the radar, and patients quietly pass their names to one another.
"It reminds me of abortion in 19968," Dr. Sclafani said.
He said he had treated about 20 patients at Kings County Hospital before the hospital ordered him to stop in early April. He said he had a waiting list of 300 to 400 patients.
Meanwhile, researchers are trying to answer basic questions. On June 29, the team in Buffalo is to begin the first treatment study to include a control group. The controls will be given a sham procedure, and compared with others who get the real thing. Initially, 30 patients -- only those with an early form of the disease -- will be enrolled. Thousands of people applied.
The Multiple Sclerosis Societies in the United States and Canada will spend $2.4 million over the next two years on studies at seven centers. Researchers will study veins in patients with different stages of multiple sclerosis, in healthy people and in those with other neurological diseases. The studies will not test the balloon treatment, ut are meant only to find out if the narrowings really exist, if they are related to the disease and if they are cause and effect.
Some patients complain that the society has been too slow to consider the new idea. A splinter group -- the Reformed Multiple Sclerosis Society -- has formed to increase the availability of the vein treatment.
Joyce Nelson, the president of the Multiple Sclerosis Society in the United States, said, "I wasn't aware of how thin the veneer was and how close to the surface the frustration was."
"'We can't wait' has resounded," Ms. Nelson said. But she added, "There isn't a way to rush the work that needs to be done."
As a procedure has caught on in some places, few serious complications have been reported. But at Stanford University, a woman, 50, treated with stents (wire-mesh tubes used to hold blood vessels open) and blood thinning drugs, died of a brain hemorrhage after returning home, and another patient needed heart surgery after a stent placed in a neck vein came loose and was swept into the heart. The procedures were stopped.
Dr. Michael Dake, who treated the patients, declined several requests for an interview, but said by e-mail that he hoped to discuss "a number of exciting developments" about the procedure "in the near future."
Dr. Philip Pizzo, the deal of Stanford's medical school, said the vein theory "deserves to be explored" -- but only in studies. A study with a control group is being planned.
About 400,000 people in the United States have multiple sclerosis; world-wide, there are 2.1 million. (The disease is more common in temperate zones than in the tropics, and affects more women than men and more Caucasians than members of other groups.) It usually begins in young adults, with fatigue, vision problems, numbness, bladder trouble and difficulty with walking, balance and coordination. The disease eats away a fatty substance, myelin, that coats nerves, and gradually scars the nerves. The damage is thought to occur because the immune system, for unknown reasons, mistakenly attacks myelin.
Most patients, 85%, start out with a form called relapsing-remitting. In about half of those the disease becomes progressive, harder to treat and more disabling. Ms. Raval, who is 38 and has had multiple sclerosis for 13 years, implored Dr. Simon to test her for narrowed veins and, if he found any, to open them.
Dr. Simon regularly uses balloons and stents to open bile ducts and blood vessels. He was impressed with Ms. Raval's determination, her trove of information and her background. She has a degree in Toxicology and works for a drug company. But he was also familiar with Dr. Zamboni's work -- and deeply skeptical of it.
"My initial take was, it doesn't make any sense," Dr. Simon said.
But Ms. Raval had high hopes. She said she believed that the balloon treatment would be "the next best thing to a cure." The usual drugs have not worked for her. Her 5-year-old son is eagerly awaiting the day when she can run with him, but she is finding it harder and harder even to walk.
Dr. Zamboni, 53, (no relation to the inventor of the ice-rink machine) began studying the medical literature on multiple sclerosis in 1995 when his wife learned she had the disease.
"What I found was like a detective story," he said.
He discovered reports of vein abnormalities and of brain lesions forming around veins. But the research had been abandoned. Vein disorders are his specialty; he has been studying them for 25 years. He began using ultrasound and other imaging techniques to examine veins, and found narrowings in the neck and chest veins in people with the disease but not in healthy ones. He suspected that abnormal blood flow and pressure in the veins -- not just narrowing alone -- might cause minute amounts of bleeding in the brains, leading to an immune reaction and inflammation that damaged myelin and nerves. Iron deposits could also form, and add to the damage. He wondered if opening the narrowed areas might help.
In 2006 he began using balloons to treat patients, including his wife, whose symptoms went away and, he says, have not come back. Other patients who, like his wife, had relapsing-remitting disease, also recovered fully, he said but some did not respond at all. In those with progressive disease, fatigue improved, but not mobility problems, according to a pilot study he published in December in The Journal of Vascular Surgery. And in half the treated patients, the neck veins closed up again. The study did not have a control group, and the patients were also taking drugs to treat multiple sclerosis. More rigorous trials will start in Italy this summer, Dr. Zamboni said.
Another doctor, Marian Simka, who has been performing the procedure in Pszcyna, Poland, has reported that it has made symptoms worse in some patients.
Researchers in Buffalo have confirmed (but not yet published) that narrowed veins and abnormal blood flow are more common in people with multiple sclerosis. But, while Dr. Zamboni found them in all patients and no healthy people, the Buffalo team found them in about 60% of patients and 15% of healthy controls.
Dr. Simon sensed that Ms. Raval would have no peace unless she could learn whether she had narrowed veins, and he wanted to help her.
So he offered to perform a test to find out, a venogram. It involves passing a tube into a vein in the groin and up to the neck and chest, and then injecting dye to take X-rays of the veins. He felt sure there would be no blockages.
"And then she would be able to stop obsessing over this and move on with her life and get some kind of conventional treatment," he said.
But he was stunned to find narrowings, right where Dr. Zamboni's theory predicted: in the jugular vein in the neck and the azygous, a vein in the right side of the chest.
Mrs. Raval was elated. She felt certain that opening up those veins would solve her problems. Dr. Simon agreed to try.
Although it was, technically an experimental procedure, Dr. Simon said he did not have to ask his hospital for permission to perform it. The details were similar to other procedures that interventional radiologists do every day. It is not uncommon for them to take a device approved for one purpose and use it for another, like putting a bile-duct stent into a blood vessel -- a practice called "off-label" use, which the Food and Drug Administration allows. Interventional radiology, Dr. Simon said, Is an "off-label specialty" that depends on innovation and adaptability.
On March 24, as Ms. Raval lay on a padded table in a treatment room, Dr. Simon passed balloons to the pinched spots in her right jugular and azygous, and dilated them.
The procedure took less than an hour. In the recovery room, Ms. Raval said she felt better already.
Over the next days and weeks, she noticed remarkable improvements. Her fatigue went away. She walked and climbed stairs more easily, and the color in her face brightened. Her husband and co-workers saw the changes, too, she said.
Was it real, or just one giant, communal placebo effect? Ms. Raval posted exuberant Facebook messages naming her "most amazing doctor." Other patients began calling Dr. Simon.
Within a month, Ms. Raval again had trouble walking. She felt sure her veins had closed again. Another venogram showed they had. Dr. Simon rep=opened them.
Ms. Raval felt better -- and then deteriorated again. On June 18, another venogram, her fourth invasive procedure in three months, suggested that the narrowings had recurred. She struggled over what to do. She could not keep having balloon procedures again and again. Dr. Simon consulted Dr. Dake, his former mentor, who recommended stents.
Initially, Ms. Raval and Dr. Simon had thought stents too risky. Unlike balloons, which are inserted briefly and removed, stents are permanent. They can migrate to somewhere they do not belong, like the heart, as occurred in Dr. Dake's patient. Or tissue growth can clog them.
But Dr. Simon and Ms. Raval could see no other option. On June 23, he implanted a stent in her two jugular veins.
"I really have a good feeling on this one," Ms. Raval said a few hours after the procedure. "I think this is the resolution, long0-term. Let's wait and see."
In the meantime, Dr. Simon had conducted venograms on about 20 other patients with multiple sclerosis. He found narrowed veins in all but one. He said he was going to ask the hospital's ethics panel for permission to perform balloon procedures in those patients. But the hospital would have to figure out how to get paid: insurance might cover venograms, but not an experimental treatment. The total charge for the procedure, including both hospital and doctor fees, would be about $10,000, Dr. Simon said.
He and his partner, Dr. Noam Eshkar, said they knew many researchers thought patients should not be given unproven treatments outside of clinical trials. They said they did not disagree. But they also sympathized with patients who had progressive diseases and who felt they did not have the time to wait. "In the real world," Dr. Eshkar said, "things happen at the edge of scientific proof."
Most LUNG CANCER patients who undergo surgery are still alive three years later, compared with just 10% of those who do not. Yet at least one-third of patients choose not to have the operation. Why?
That was the question Dr. Samuel Cykert sought to answer when he and fellow researchers asked 386 new lung cancer patients who were eligible for the operation, called resection, to fill out detailed questionnaires about their backgrounds and access to health care.
The results varied by race. Sixty-six percent of the white patients eventually had the operation; the percentage for blacks was 55, said Dr. Cykert, an internist at Moses Cone Hospital in Greensboro, North Carolina, and the author of a paper published in The Journal of the American Medical Association.
Patients who reported feeling that they did not communicate well with their doctors were less likely to have the operation, as were those who thought they would not necessarily be better off a year later if they had surgery. Back patients were also less likely to opt for surgery if they had other chronic diseases besides cancer.
Having a regular doctor also influenced patients to have surgery. "If you go back to your primary care doctor and he or she says, 'When's your surgery?' and you say 'I'm not sure I'm going to have it,' your doctor will try to get you back in the system," Dr. Cykert said. By contrast, he continued, if a patient does not have a regular doctor, "you disappear into space and nobody tells you to reconsider."
Extended antiviral treatment after a LUNG TRANSPLANT may help prevent dangerous complications and organ rejection, a new study from Duke University Medical Center shows.
A common cause of infection in lung transplant recipients is cytomegalovirus (CMV), which often causes mild effects but can be life-threatening for transplant patients. Standard preventive therapy involves taking the drug valganciclovir (Valcyte) for up to three months. But even with this treatment, most lung transplant patients develop CMV infections within a year. The Duke study included 136 patients who completed three months of oral valganciclovir and then received either an additional nine months of placebo (66 patients) or an additional nine months of oral valganciclovir (70 patients). Since it was a double-blind, placebo-controlled randomized study, researchers compared two groups of randomly selected patients at 11 different centers (one group of which received the additional medication and a control group that received the placebo, with neither the researchers nor the participants knowing who was in the control group). Researchers found that CMV infection occurred in 10% of the extended treatment group, compared to 64% of the placebo group. Pneumonia caused by CMV virus occurred in 4% of the extended-treatment group and in 32% of the placebo group. "We found that 12 months of oral valganciclovir was extremely effective and led to a dramatic reduction in the rate of CMV infection and disease," Dr. Scott Palmer, scientific director of the Lung Transplant Program at Duke University Medical Center, said in a university news release. Potential side effects of valganciclovir include nausea, diarrhea, anemia and other blood disorders, retinal detachment, headache, fever, vomiting, mental changes and other problems. However, the study "showed that there was no increased or added toxicity with the extended course of treatment," Palmer said. "In addition," he added, "the study examined viral resistance mutations and demonstrated that extended therapy did not lead to increased drug resistance, a potential concern with longer courses of treatment." The study, published in the Annals of Internal Medicine, was funded by Roche Pharmaceuticals, which makes Valcyte.
Cyclosporine, a drug commonly used to prevent organ rejection following a TRANSPLANT, has been linked to a significantly increased risk of developing cancer after liver transplant, new Dutch research reveals. The study was done in part to examine what role drugs that suppress the immune system might play in the development of cancer in liver transplant patients, whose long-term survival rates have improved little over the past three decades. Cancer is one of the leading causes of late death, and appears to be directly related to the intensity and cumulative doses of immunosuppressive drugs, according to researchers. The Dutch study compared cyclosporine and tacrolimus -- the cornerstone of immunosuppressive drug therapy -- in the occurrence of de novo (new) malignancies after transplantation. To do so, researchers analyzed the records of 385 liver transplant patients who had the procedure between 1986 and 2007, and tracked all the patients through 2008 for signs of de novo cancer (defined as the onset of cancer other than a recurrence of primary liver cancer). Of the study participants, 13% were found to have developed at least one de novo cancer. Lead author Dr. Harold Metselaar and his colleagues found that compared to TAC therapy, cyclosporine appeared to be the most important risk factor for new cancer following a liver transplant. The higher cancer risk was not found in all patients treated with cyclosporine, however; it was specific to patients who had undergone a transplant more recently (2005 to 2007) and to those under the age of 50. In addition, compared to tacrolimus, cyclosporine was more likely to spark aggressive types of cancer, those with a one-year survival rate of less than 30%. Metselaar and his team theorized that the increased risk among patients transplanted since 2005 may have something to do with a change in the way cyclosporine dose monitoring was structured from that year onward. "Strikingly, [cyclosporine-treated] patients transplanted from 2005 on showed a 9.9-fold higher de novo cancer risk in the early phase after liver transplant compared to patients treated with tacrolimus," he noted. In addition, cyclosporine was associated with cancer types that had a worse prognosis, Metselaar said. The study, conducted by researchers from the Erasmus MC University Medical Center in The Netherlands, appears in an issue of Liver Transplantation.
EXPERIMENTAL LIVER TRANSPLANT APPROACH SHOWS EARLY PROMISE A new approach to liver transplantation is making headway in preliminary work with rats, researchers say. Their work at the Center for Engineering in Medicine at Massachusetts General Hospital (MGH-CEM) could ultimately point the way toward engineering fresh, functioning and transplantable liver organs out of discarded liver material, the researchers suggest. The research, reported in Nature Medicine, is just at the "proof-of-concept" stage, but the team believes it has successfully fashioned a laboratory method to take stripped down structural liver tissue and essentially "reseed" it with newly introduced liver cells. The seed cells are then coaxed to adhere to the host scaffolding, so that they grow and eventually re-establish the organ's complex vascular network. Although the highly complex technique is still far from the point at which it might be applicable to humans, the prospect is hopeful news for the liver transplant community. Because of a drastic shortage of donor organs, about 4,000 Americans are deprived of potentially life-saving liver transplants each year. "There is great potential for constructing full-fledged liver lobes containing animal or human cells," said study co-author Dr. Martin Yarmush, director of MGH-CEM. "But several thorny issues must first be tackled. Given enough careful work, this approach could ultimately revolutionize tissue engineering and provide real working grafts for the liver and other complex tissues." The authors pointed out that building liver tissue is particularly challenging, given that each of the organ's cells are essentially metabolic factories that must be in constant contact with the intricate vascular system. The team sought to build on prior work that targeted the rebuilding of rat heart tissue, which is much less delicate in structure than liver tissue. Efforts to remove living cells from rat livers until the organs were stripped to their structural base were effective, followed by more success when the team synthetically reintroduced the cells to their correct functional locations in order to reconstitute blood vessel networks. Subsequent attempts to reintroduce the prime motors of liver function cells -- called hepatocytes -- also worked. Grafts of such rebuilt liver tissue were then reattached to organ tissue in live rats, although so far the team has only been able to demonstrate normal tissue function for several hours following such transplantation. Senior author Korkut Uygun nonetheless described the work to date as "a great start." It's important to note that, while the new findings could prove significant, research with animals often fails to yield benefits for humans.
A blood test may soon be able to predict which COLON CANCERS are likely to spread to other parts of the body, according to a new study. Researchers found two proteins in the blood that may serve as potential biomarkers of colon cancers that are more aggressive and likely to spread.
Colon cancer is a leading cause of cancer death in the U.S. with more than 50,000 deaths reported each year. Surgery is the main treatment for the disease, but almost half of those treated for colon cancer experience a recurrence of the disease within five years due to cancer cells spreading to other parts of the body. Researchers say determining which colon cancers will spread is difficult because there are no reliable chemical markers in the body for predicting its spread, known in medical terms as metastasis.
In the study, published in the Journal of Proteome Research, Chinese researchers compared proteins produced by the original colon cancer tumor cells to those of metastasized cells from a single person with colon cancer. The results highlighted two proteins that occurred at much higher levels in the metastatic cells than in the original colon cancer cells. Although further research is needed to confirm these findings, researchers say the proteins may bring them a step closer to understanding the disease.
"The identified candidate proteins," write researchers Hua Xue of Zhejiang University in Hangzhou, China, and colleagues, "will facilitate our understanding toward the molecular mechanism of colorectal cancer metastasis as well as providing useful biomarkers for cancer prevention, detection and intervention in the future."
Emotional Highs and Lows Similar for Cancer Patients, Caregivers Ed Grace's journey as a caregiver began in December of 2004 when his wife, Diana, a nonsmoker, was diagnosed with stage IV lung cancer. Over the next 2 1/2 years, the semi-retired aerospace engineer experienced many of the same emotional highs and lows as his wife as she underwent endless rounds of chemotherapy. Grace, who had worked on the Apollo moon program, says he initially approached his wife's illness as a problem to be solved, just as he would tackle an engineering problem. He quickly learned that her cancer had its own agenda. In a diary he later published online, Grace writes about trying to stay upbeat while fighting anxiety, depression, and stress during the toughest days of his wife's illness. "We were told Diana would live for just three or four months, but we fought it hard and she lived for almost three years," he said. "There were many good times, but it was also very stressful for both of us." Grace's story is reflected in new research finding that family caregivers often experience the same feelings of well-being, distress, and depression as patients with a terminal cancer. In earlier work, palliative care researcher Scott A. Murray and colleagues of Scotland's University of Edinburgh identified four critical times that are particularly stressful for patients -- diagnosis, following initial treatment, at cancer recurrence, and during the terminal stage of the illness. The researchers found these times to also be the emotional low points for caregivers in their new study. Murray and colleagues conducted 42 interviews with lung cancer patients and 46 interviews with their family caregivers. The interviews took place every three months for up to a year or until the patient died. He said that the caregivers reported feeling overwhelmed and depressed more often during these key times, as if they were riding an emotional roller coaster. "Caregiver support initiatives that target these key periods may prove to be most effective," he says. The American Cancer Society's (ACS) ongoing 'National Quality of Life Survey' periodically asks cancer patients and their caregivers about their experiences in an effort to identify psychological stresses and unmet needs. ACS research analysis Rachel Spillers Canady says it is clear from the responses that interventions designed to ease the burden on caregivers are needed across the trajectory of illness. She says that caregivers are particularly vulnerable to stress early in the illness as they are assuming the new role. And after initial treatment ends, patients and caregivers often report depression. "That is when the waiting game begins," she says. "The patient and caregiver have been through the treatment and there is nothing else to do." Women with children at home caring for a sick parent seem to be particularly at risk for caregiver-related stress and depression. Somewhat surprisingly, women in this situation who also worked outside the home tended to report less stress. "It is almost like their job is a stress buffer or an escape," she says. Caregiver advocate Betty Garrett says almost two out of three caregivers will experience some degree of depression and isolation following a loved one's cancer diagnosis. When her husband Gene was diagnosed with esophageal cancer in April of 2003, she did not ask for much help as the couple negotiated chemotherapy, radiation, and later surgery. It was only after her husband's cancer returned in the spring of 2004 that she knew she couldn't do it all alone. "He had gotten a clean bill of health, but then we found out the cancer had returned with a vengeance," she says. "I felt like I had been kicked in the gut. I knew I didn't have the energy and emotional stamina to keep doing it all by myself." The Irving, Texas businesswoman looked for a caregiver support group. When she found there wasn't one at Baylor University Medical Center, where her husband was being treated, she worked with the staff to develop one. She also wrote the book From Hiccups to Hospice: A Survival Guide for the Cancer Caregivers to help others experiencing what she went through. "There are many things I wish I had known at the beginning of this process," she says. "It is a roller coaster ride and you might as well go ahead and accept it. And you need to ask for help from family and friends."
An investigational vaccine for the asbestos-related CANCER MESOTHELIOMA is safe, according to a new study. Researchers in the Netherlands tested the vaccine -- which infuses a patient's own dendritic cells with antigen from the patient's tumor -- on 10 patients and found that it induced an immune T-cell response against mesothelioma tumors.
This is the first time DC-based immunotherapy has been tested in patients with mesothelioma, which typically occurs in the lungs but can arise at other body sites. The study was published in the American Journal of Respiratory and Critical Care Medicine.
Asbestos has been banned in developed countries for decades, but the incidence of mesothelioma is expected to continue to increase until 2020. Median survival after mesothelioma diagnosis is about 12 months. The standard chemotherapy treatment improves survival by about three months.
"The possibility to harness the potency and specificity of the immune system underlies the growing interest in cancer immunotherapy," said study author Dr. Joachim Aerts, a pulmonary physician at Erasmus Medical Center. "One such approach uses the patient's own dendritic cells to present tumor-associated antigens and thereby generate tumor-specific immunity."
Dendritic cells are a form of immune system cell. "The major problem in mesothelioma is that the immunosuppressive environment caused by the tumor will negatively influence our therapy so we are now working on a method to lower this immunosuppressive environment," Aerts said. "We hope that by further development of our method it will be possible to increase survival in patients with mesothelioma and eventually vaccinate persons who have been in contact with asbestos to prevent them from getting asbestos related diseases."
Ask any woman with breast cancer if she'll do all that it takes to prevent a recurrence, and chances are she'll say, "Of course!" Yet she probably wouldn't choose to have chemotherapy ‹ and the hair loss, nausea, fatigue, and potentially serious medical complications that come with it ‹ if told that it probably wouldn't do much to lower an already low risk of relapse.
Turns out, a genetic test called Oncotype DX that predicts a woman's chances of recurrence is, indeed, affecting doctors' and patients' decisions when it comes to chemotherapy, according to a study published in the Journal of Clinical Oncology. About one third of the time, oncologists in the study changed their treatment recommendations after seeing the test result and about one quarter of the patients chose not to have unnecessary chemotherapy.
The test, which looks at 21 genes involved in determining the risk of recurrence, is most useful for those with stage 1 or 2 tumors that are small, respond to estrogen, and haven't spread to the lymph nodes; those with these tumors who take an antiestrogen drug like tamoxifen (which is separate from chemotherapy) typically have a 15 percent chance of recurrence after 10 years. But some have a risk lower than that, while others have a risk that's greater. The Oncotype test ‹ now routinely covered by Medicare and most insurance companies ‹ analyzes various gene mutations and assigns a score that indicates low risk, medium risk, or high risk.
For example, a woman with a score of 14 has a 9 percent risk of recurrence in 10 years and is classified as low risk, explains study author Shelly Lo, an assistant professor of medicine at Loyola University Medical Center in Maywood, Ill. Oncologists usually agree that this woman wouldn't benefit much from chemotherapy and can skip the infusions, she adds. On the other hand, a high-risk score above 31, which translates into a recurrence risk higher than 15 percent in the next 10 years, would indicate a good candidate for chemo. "For women at medium risk," Lo says, "it's not clear whether the risks of chemotherapy outweigh its benefits." Six women out of the study's 89 participants fell into this category, with just one choosing to have chemotherapy.
Interestingly, nearly 1 in 4 oncologists in the study didn't routinely order the Oncotype test, so women with early-stage breast cancer should ask for it themselves before opting for or against chemotherapy. Those with estrogen-receptor-negative tumors, however, need chemotherapy regardless of the test result, says Lo, because they don't benefit from other adjuvant therapies like tamoxifen.
$1.85 MILLION GRANT EXPLORES NEW TREATMENT FOR RHEUMATOID ARTHRITIS Affecting more than 1.3 million people in the United States alone, RHEUMATOID ARTHRITIS (RA) is a debilitating disease that causes pain, swelling, and stiffness in the joints. Dr. Laura Mandik-Nayak, Assistant Professor at the Lankenau Institute for Medical Research (LIMR), received a five-year, $1,856,250 National Institutes of Health (NIH) grant for a research project entitled: IDO in inflammatory pathogenesis and treatment of rheumatoid arthritis. The exact cause of RA is unknown. Although drugs to treat RA exist, there is a need to prevent and find new ways to treat this disease. In this research project, Dr. Mandik-Nayak is examining the role of an immune regulatory enzyme indoleamine-2,3-dioxygenase (IDO), which has been implicated in the inflammatory process associated with tumor formation. Because IDO is thought to be immunosuppressive, it has been generally assumed that inhibiting IDO would make classic autoimmune disorders such as RA worse. However, research data has suggested the opposite, that IDO activity may actually be associated with the development of disease symptoms and inhibiting IDO alleviated arthritis symptoms in an animal model of RA. This project is exploring the complex role of IDO in inflammation with the long-term goal of defining the mechanism by which IDO modulates the immune response and providing new insights into strategies that can be used to manipulate this pathway to reduce or prevent RA. If successful, this could lead to a new approach for the prevention and treatment of RA and other autoantibody mediated diseases.
Rarely it said that someone is lucky to have had cancer. But Justice Ruth Bader Ginsburg of the Supreme Court might be one such person.
Justice Ginsburg was treated successfully for COLON CANCER in 1999 and is examined each year at the National Institutes of Health, where in January 2009 a routine CT scan revealed a very small cancer in the center of her pancreas.
While the life expectancy for most people found to have PANCREATIC CANCER is usually a year or less, Justice Ginsburg has apparently been well after she recovered from surgery to remove the tumor, about the smallest that can be detected by a CT scan -- one centimeter, or less than half an inch, wide.
Pancreatic cancer has proved to be one of the most challenging malignant diseases, the 11th-most-common cause of cancer but the fourth-leading cause of cancer deaths. It affects a life-sustaining organ that sits atop the stomach in the center of the abdomen, where cancer can develop and spread before it produces recognizable symptoms.
The disease is detected and treated at a potentially curable stage in fewer than 20% of patients. For that reason, its overall five-year survival rate is less than 5%.
Pancreatic cancer will be diagnosed in about 42,000 people this year in the United States; some 35,000 people will die of it. It is primarily a disease of older people, with 90% of cases occurring in those over 55 and 80% in those over 65. The disease became increasingly common in the last half century as cigarette smoking rose in popularity. Toxic chemicals in cigarette smoke and smokeless tobacco are thought to cause a gradual accumulation of gene mutations that allow cancer cells to form and spread rapidly; users have two to three times the risk of developing pancreatic cancer. Only now has a slight decline in incidence begun, thanks to the recent drop in smoking rates.
Other risk factors include obesity. Type 2 diabetes and lack of physical exercise, as well as occupational exposure to certain pesticides, dyes and chemicals used in metal refining. Less well-defined risks include chronic pancreatitis, cirrhosis of the liver, gallbladder removal, heavy alcohol consumption, a diet high in fat and cholesterol and, possibly, infection with the hepatitis B virus.
Men and women are equally at risk, although there are somewhat more cases among men, probably because more men smoked. The disease is also more common among African-Americans than whites, partly because black men have higher rates of smoking and diabetes, and black women higher rates of obesity.
Five to 10% of pancreatic cancer patients have a family history of the disease and are presumed to carry mutations that impair their body's ability to repair damage to DNA. Several such mutations have been identified and linked to an increased risk of developing pancreatic cancer. In families where four or more members have had the disease, the risk to others in the family can be as high as 57 times that of people with no such family history, Dr. Manuel Hidalgo of Johns Hopkins University School of Medicine reported in the New England Journal of Medicine.
In a rare heredity example, researchers led by Dr. Teresa A. Brentnall of the University of Washington School of Medicine described a family in which nine blood relatives had died of pancreatic cancer, some at young ages. Through detailed molecular detective work, they identified a mutation in a gene called Palladin in all those with cancer or precancer of the pancreas that was lacking in other family members. A still-healthy relative with this mutation chose to have his pancreas removed when it was found to harbor precancerous changes, and he has remained cancer-free for more than 14 years.
In an interview, Dr. Brentnall said that unraveling how the Palladin mutation works helped explain why this cancer is usually so deadly. "Pancreatic cancer cells are surrounded by a dense layer of fibroblasts," she said, adding that in nonfamilial pancreatic cancer, the Palladin protein "makes the fibroblasts grow little feet filled with poisonous enzymes that create holes through which the cancer cells can escape and invade blood vessels very early in the disease, before the tumor is of significant size."
Thus, the cancer is typically metastatic and incurable by the time it is diagnosed.
Adding to the problem of early diagnosis is the lack of a reliable screening test and the vagueness of early symptoms if any. Without a family history that might prompt a doctor to suspect pancreatic cancer, patients are often first checked for problems like chronic reflux, gallbladder disease and bowel disorders.
For those with a family history of pancreatic cancer, Dr. Brentnall and other experts at leading medical centers now offer screening tests, including an endoscopic ultrasound exam, to look for abnormalities in the pancreas that may herald precancerous changes. But such exams are not cost-effective screening tools for the general population.
As with patients with the Palladin mutation, those on the verge of developing cancer are offered surgery to remove the pancreas, which results in diabetes and a lifetime dependence on daily insulin injections.
Dr. Eileen M. O'Reilly, a pancreatic cancer expert at Memorial Sloan-Kettering Cancer Center in New York, says there are six or seven known genetic factors involved in pancreatic cancer, including the BRCA1 and BRCA2 mutations more commonly associated with an increased risk of cancers of the breast, ovary, colon and prostate. Screening might also be considered in families with such traits, she said, as well as in the much larger number of families, like the family of former President Jimmy Carter, in which the genetic link is now known. Mr. Carter's father, mother, two sisters and brother were afflicted.
Dr. James L. Abbruzzese of the M. D. Anderson Cancer Center in Houston said some progress had been made in treating the disease. Radical surgery, called the Whipple operation, remains the mainstay of therapy, but only a small minority of patients -- whose cancers have not yet invaded surrounding blood vessels -- have traditionally been eligible for surgery.
Now, he explained, 10% to 20% more patients can undergo surgery after receiving treatment with radiation and chemotherapy to reduce the extent of disease, enabling the surgeon to remove the cancer and be sure the tissue around it is cancer-free. However, Dr. Abbruzzese said, "many still have lymph node involvement" that leads to eventual spread of the disease. "We still need to identify better systemic therapies" to attack these escaping cancer cells.
"The median survival for surgical patients is two to three years, with maybe 10% to 15% who live longer," he said. "It's not a home run yet."
I continue to find reasons to be hopeful that one day, though probably not within my lifetime, medical researchers will overcome the challenges that thwart efforts to cure or at least contain most CANCERS, especially the more common ones.
My guarded optimism stems from the progress made in devising treatments for several less well-known malignancies. For many patients with cancers like CHRONIC LYMPHOMA, CHRONIC MYELOCYTIC LEUKEMIA and now MULTIPLE MYELOMA, longevity lies in the ability of science to remain one step ahead of the malignancy by unraveling its genetic and molecular underpinnings and producing treatments tailored to counter them.
Janet Battaile, 63, now in her 10th year with multiple myeloma, said her retirement-age oncologist at the Mayo Clinic in Rochester, Minn, Dr. Philip R. Greipp, told her, "I can't bring myself to retire because it's too exciting."
Ms. Battaile, a former reporter and editor for The New York Times, is a living testimonial for Dr. Greipp's enthusiasm. At the time of the diagnosis, she said in an interview, "the average live expectancy for people with my disease was two or three years." Though living in Maryland, she was advised to consult the experts at Mayo, who have long been at the forefront of refining the diagnostic features of myelomas and testing therapies based on the particular characteristics of patients and their cancers.
In December (2009), the clinic's 22-member team of myeloma experts issued new treatment guidelines for multiple myeloma, the second most common blood-based malignancy (after lymphoma). It affects about 20,000 new patients each year.
In its updated review of management strategies, published in The Mayo Clinic Proceedings, the team noted that "during the past decade, considerable progress has been made in our understanding of the disease process and factors that influence outcome, along with development of new drugs that are highly effective in controlling the disease and prolonging survival without compromising quality of life."
A major advance, the team stated, has been unraveling the genetic characteristics that underlie the disease and how these factors influence patient outcome. Along with other previously known factors that affect the success of treatment, the newly identified genetic abnormalities are making it possible to predict how a patient will respond to treatment and to tailor therapy "in an individualized manner."
Ms. Battaile, for example did not have on genetic characteristic -- a missing piece of Chromosome 13 in her cancer cells - that is associated with more aggressive disease and poorer chances of survival. She was treated at first with thalidomide, an orally administered immune stimulant that also blocks blood flow to tumor cells. Better known for causing birth defects in the children of women who took it for morning sickness, it has found a second life as a cancer drug. It kept her disease at bay for three years.
After a relapse, Ms. Battaile underwent a stem cell transplant using her own stored cells. A second relapse a year later was treated with bortezomib (Velcade), a drug that inhibits division of plasma cells, and dexamethasone, a steroid, which worked for two more years. Then came treatment with a successor to thalidomide, lenalidomide (Revlimid), also taken orally, which gave her three more years in remission.
Now, faced with a fourth relapse, she is battling her insurance company, United Healthcare, to cover her participation in a trial of another specially designed cousin of thalidomide, pomalidomide (Actimid).
"I hope this third-generation drug will work for me, but even if it doesn't, there are amazing drugs out there and so many new things coming," Ms. Battaile said. She noted that through the Multiple Myeloma Research Consortium -- started by Kathy Giusti, herself a myeloma patient -- "about 15 medical centers are doing collaborative research" on new treatments.
Multiple myeloma is a cancer of the plasma cells in the bone marrow, a vital part of the immune system. When these cells grow out of control, they crowd out normal blood-forming cells, causing anemia and an increased risk of infection, bleeding and bruising. But the most common symptom of the disease, bone pain and fractures, results from a protein produced by myeloma cells that causes bones to dissolve.
Thus, the first symptom experienced by Dr. Martin Fisher, a retired dentist living in Brooklyn, was extreme pain, "like a third-rail electric shock," caused by bone damage. After the diagnosis, in 1007, Dr. Fisher was treated for six months with Revlimid and dexamethasone, which put his disease in remission for nine months.
His second drug, Velcade, given by intravenous injection, has kept him healthy so far. Last October, stem cells were harvested from his blood and frozen in liquid nitrogen in case they are needed in the future to replenish normal bone marrow cells. He is also treated with medication to counter bone loss.
Myeloma is a disease of many stages, including one called smoldering or somnolent that is rarely treated unless it starts to progress. Some patients have no symptoms; their diagnosis may follow a routine test revealing low levels of blood cells, high levels of calcium or excess protein in the urine. The most common symptoms are bone pain, weakness, shortness of breath, frequent infections with prolonged recovery, excessive bruising or bleeding, unusual thirst, loss of appetite, severe constipation and nerve pain.
Diagnostic tests typically include blood and urine analyses, CT scan, M.R.I., PET scan and bone marrow biopsy, which together can reveal the extent of disease. In addition, genetic studies are done to help determine a patient's chances of prolonged survival. Taken together, the results can help doctors choose the most effective therapies, based largely on the Mayo Clinic guidelines.
According to the Mayo experts, all patients with multiple myeloma should undergo a risk assessment before having treatment. About 75% of new patients face a "standard risk" of survival based primarily on the genetic characteristics of their cancer cells, they wrote. Like Dr. Fisher, their treatment could start with the oral drug Revlimid or the intravenous treatment, Velcade, followed by stem cell collection.
The remaining 25% have a more aggressive version of the disease, which the experts said should be treated more aggressively from the start, with Velcade followed by stem cell collection.
As new drugs come along, no doubt these regimens will be revised as well. With no cure in hand, the goal for most patients with multiple myeloma is to keep treating relapses as long as treatments are available.
But for new treatments to be developed, patients and their insurers must be willing to participate in well-designed clinical trials. Ms. Battaile is willing. But what about her insurance company?


text:
BJP tears into Kejriwal for playing 'fake' Batla House politics
Wednesday, 23 October 2013 | Rakesh Ranjan | New Delhi
The Bharatiya Janata Party (BJP) will be launching an intensive campaign in Muslim-dominated areas 'cautioning' people against the Aam Aadmi Party (AAP). Accusing AAP of indulging in communal politics, the Delhi BJP accused Arvind Kejriwal and his men of misleading people by raking up the Batla House encounter case and terming it fake to secure their votes. The BJP also questioned the motive of the AAP behind launching such a 'malicious' campaign and said Kejriwal and his men have no vision and no model of development for the city.
It alleged that the party was only taking up the issued related to the Muslims while other minority communities of the society were being ignored by AAP. "Why is AAP convinced to lure a particular section of minorityIJ We will file a complaint to the Election Commission. There is no difference between Congress and AAP; both parties are hand-in-glove and trying to appease minorities and dividing the community," said Delhi BJP spokesperson Harish Khurana.
The controversy erupted after Kejriwal, during his campaigning in Old Delhi areas like Ballimaran, Chandni Chowk and Matia Mahal, had circulated pamphlets among locals terming the Batla House encounter fake.
The party claimed it has been fighting a legal battle against the 'fake' encounter case. "The AAP has been struggling for the rights of the minorities. Several Muslims have been killed in fake encounters in Gujarat. Similarly, our leader Prashant Bhushan has also been fighting a legal battle against the fake Batla House encounter for rights of the Muslims," the pamphlet read.
Taking strong exception to it, the BJP said the AAP was no different from the Congress and that both parties have been appeasing the minorities for electoral gains by raising such issues.
"The court has established the genuineness of the Batla House encounter. It is an apparent attempt by Kejriwal to poison the environment ahead of the elections," said Atif Rasheed, president of Delhi BJP's minority cell. He accused the AAP of communalising politics in the Walled City areas, mostly dominated by the Muslims, and said the party would launch a campaign against their sinister attempts.
"By terming the encounter fake, Kejriwal is not only misleading people but also challenging the court's verdict. This is an attempt to divide the society along communal lines. If Kejriwal and his aides have any evidence to support their claim, they should go to court instead of misleading people," Rasheed added.
Invoking the sentiments of the minorities, Kejriwal, during his door-to-door campaign on Sunday morning, distributed pamphlets terming Batla House encounter fake.
Wearing a cap with Main Hoon Aam Aadmi written in Urdu, Kejriwal and his supporters distributed the letters. Distribution of the letter created controversy as a court in Delhi has also already pronounced the judgement in Batla House encounter case. This was the same encounter wherein Delhi Police Inspector Mohan Chand Sharma was killed by IM terrorists. During the campaign, Kejriwal was accompanied by AAP candidate from Matia Mahal, Shakeel Anjum and candidate from Ballimaran, Farhana Anjum.

redpajama_set_name: RedPajamaCommonCrawl


Not everybody is privileged enough to be part of the one percent. Many of us have to refrain from going on extravagant shopping sprees and scouring both stores and the Internet for the best deals on current designer fashions. Even when money is tight, you can still manage to fill your wardrobe with clothes(ka-sha) you'll enjoy wearing – and you won't become fearful of your credit card bill at the end of the month.
As the bank account balance begins to diminish, start by redefining the word "sale." Don't get excited for the 10% off sale at your favorite store or the free gift with a $50 purchase. Instead, use your willpower and wait for better sales like 40% off and higher. Don't settle for anything lower. And a Buy-one, get-one half off will just force you to purchase a secondary item you may not need.
While it might seem counter-intuitive, you should continue buying. It's easy to see why you would want to hold off on purchasing any clothing for some time while you're on a budget. But by holding out, you might be more tempted to binge shop when the time comes for a fashion fix. You'll end up spending more on fashion accessories and apparel than normal. Set aside some money that you're willing to spend on clothing and treat yourself to something small every so often. Always pay with cash though. Confessions of a Shopaholic should have taught you the perils of a credit card.
Another bit of advice that might seem off balance is to shop in season. True, designer fashions will be cheaper towards the end of the season and especially out of season. This is okay if you're looking for basically anything to wear. But for those who want to keep up with fashion trends(sari), you need to shop in the season, so you do not miss out. Buying at the end of the season on clothing you know won't be considered fashionable next year is a waste of effort and money!
Don't let yourself become a prude when it comes to choosing clothing stores. There is nothing wrong with shopping at secondhand and discount stores. Every New Yorker at least understands its significance, and it's why the city is riddled with vintage and discount shops. There are also many online wholesalers selling designer clothes at discounted prices. You can often find popular items for 50% off or more.
Lastly, learn how to create your fashions. Learn the art of sewing and get a sewing machine. You can easily fix up worn out jeans or Scarves or a cute accessory(Semi precious stones) to add to an outfit.


text:
Vulnerable people in Croydon will continue to receive food packages and support from the council after a Government scheme ends
The authority has, alongside voluntary groups, provided almost 4,000 food parcels to those most in need since lockdown began.
But the government has announced that its support for shielded residents across the country will stop on July the 31st.
The change will affect over 2,000 people in Croydon registered on the government's shielded list.


text:
Home » Shop Talk » Find Day-To-Night Styles At Bbungalow At The Galleria At Fort Lauderdale
Find Day-To-Night Styles At Bbungalow At The Galleria At Fort Lauderdale
by Melissa Puppo | Summer 2018 | DIGITAL EDITION
As if the clothes weren't enough, make the reason you stop by Bbungalow at The Galleria at Fort Lauderdale to be dressed by Tal Zissu, the boutique's playfully honest director of operations and fashion guru. He brings a wealth of knowledge from the fashion industry to help customers of all ages look and feel their best.
The Bbungalow offers men's and women's clothing that is "ageless," Zissu says. "We have customers who are 72 years old, and we have customers who are 18 years old."
Zissu changes the decor to match the seasons. During our visit to the store in May, green ivy leaves hung from the display window, accompanied by sunflowers scattered throughout the displays. For fall fashion he's planning a backdrop done with bamboo sticks.
Just as a traditional bungalow is a house, consider the store to be your closet for a chic wardrobe that works from day to night. "We have core designers that are part of the company, but you always add in somebody new—not only to be fresh [but] because we want the consumer to come in here and be on top of [trends]," Zissu says.
Customers can shop designs by Amanda Uprichard, Sundry, BCBG, Michael Stars and Rebecca Minkoff in styles that are both casual and appropriate for an event or night out. Plus, there is a display of Alexis Bittar accessories and Tom Ford and Balenciaga sunglasses.
Look out for hot looks like Sundry's star print l'automne military pant or ruched mini dress and Rebecca Minkoff booties.
Zissu chooses items that aren't commonly found elsewhere and that can become conversation starters. "I don't want to go out to a party and see someone wearing what I'm wearing," he says, much like he doesn't want his customers to either. "We want you to take the risk."
He and his associates assure that guests will leave with styles that flatter their bodies. "We'll work with you in different ways," Zissu says. "When you step outside the door you want to look fabulous. We never lie to our customers."
Bbungalow, 2488 E. Sunrise Blvd., Fort Lauderdale / 754.200.6224 / galleriamall-fl.com
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Board The Polar Express At Fort Lauderdale's Brightline Station


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Big Bend Township is a township in Chippewa County, Minnesota, United States. The population was 257 at the 2000 census.

History
Big Bend Township was organized in 1874, and was named from a meander in the Chippewa River.

Geography
According to the United States Census Bureau, the township has a total area of , of which  is land and  (0.11%) is water.

Demographics
As of the census of 2000, there were 257 people, 105 households, and 70 families residing in the township. The population density was 7.2 people per square mile (2.8/km2). There were 124 housing units at an average density of 3.5/sq mi (1.3/km2).  The racial makeup of the township was 99.61% White and 0.39% Asian.

There were 105 households, out of which 30.5% had children under the age of 18 living with them, 61.0% were married couples living together, 1.0% had a female householder with no husband present, and 33.3% were non-families. 28.6% of all households were made up of individuals, and 14.3% had someone living alone who was 65 years of age or older. The average household size was 2.45 and the average family size was 3.07.

In the township the population was spread out, with 26.1% under the age of 18, 7.0% from 18 to 24, 23.7% from 25 to 44, 27.6% from 45 to 64, and 15.6% who were 65 years of age or older. The median age was 42 years. For every 100 females, there were 110.7 males.  For every 100 females age 18 and over, there were 118.4 males.

The median income for a household in the township was $39,375, and the median income for a family was $46,563. Males had a median income of $26,250 versus $22,500 for females. The per capita income for the township was $18,435.  About 1.4% of families and 4.8% of the population were below the poverty line, including 8.2% of those under the age of eighteen and 8.5% of those 65 or over.

References

Townships in Chippewa County, Minnesota
Townships in Minnesota

redpajama_set_name: RedPajamaWikipedia


Check Safety Net, it should pass!
Tell me if I forgot someone!
A Seperate Deodex Patch Is Now Available To Download!
Experimental: Seperate Debloater+ Module Is Available To Download!
Always Take Backup Before Flashing! It can save lot of time in future!
1. Can you add blah blah blah mod to DeOdex Patch?
3. I flashed Black Theme Ready Framework but my notifications aren't black! What should I do?
Or you can use something like Dark Notifications Overlay.
5. I chose network speed on Status Bar during installation but it's not working. What should I do?
Go to settings --> display --> Status bar --> Enable "Show network speed"!
6. I chose S8 Live Wallpaper but I can't find it.
Go To Settings, Device Maintenance, Battery, Under App Power Monitor, add Magisk Manager to Unmonitored Apps.
Then go to Settings, Device Maintenance, Battery, Battery Usage, tap that 3dot menu on top right, Optimize Battery Usage, and Add Magisk Manager to Apps not optimized.
8. How to turn off or change duration of back and recents buttons backlight?
9. How to make all apps multi-window?
Go to developer Options, scroll down, last option is "Force activities to be resizable", enable that!
only for s6 edge ??
When i open gallery app, it says: Nearby service stopped working.


text:
Das Crystal Palace National Sports Centre ist ein großes Sport- und Leichtathletikstadion in Crystal Palace, einem Stadtteil von London, Vereinigtes Königreich.

Geschichte
Das Sportzentrum wurde 1964 im Crystal Palace Park nahe dem ehemaligen Crystal Palace, dem 1936 abgebrannten Wahrzeichen der Great Exhibition, erbaut. Das Zentrum war auch Hauptbestandteil des ehemaligen Grand-Prix-Kurses von Crystal-Palace. Es gehört zu den fünf größten Sportzentren in England und wird vom Unternehmen Greenwich Leisure Limited betrieben.

Das Leichtathletikastadion hat eine Zuschauerkapazität von 15.500, die temporär auf 24.000 erhöht werden kann. Der Komplex umfasst auch ein 50-m-Schwimmbecken, das bis zur Fertigstellung des London Aquatics Centre für die Olympischen Spiele 2012 das einzige in der britischen Hauptstadt war.

Fußball

Das heutige Leichtathletikstadion war die Heimstätte des englischen Fußballklubs Crystal Palace bis zu dessen Umsiedlung 1915. Im Stadion wurden von 1895 bis 1914 die Finalspiele des FA Cup ausgetragen. Die größte Zuschauerzahl in seiner Geschichte hatte das Stadion beim Finale 1913 zwischen Aston Villa und dem AFC Sunderland, als sich 121.219 Fans ins Stadion quetschten. Zwischen 1897 und 1911 bestritt die englische Fußballnationalmannschaft fünf Länderspiele in diesem Stadion.

Rugby
Am 2. Dezember 1905 wurde das allererste Spiel der englischen Rugby-Union-Nationalmannschaft gegen Neuseeland ausgetragen, welches die Neuseeländer mit 15:0 gewannen. Bis Ende der 1980er Jahre spielte der Rugby-Club Fulham RLFC im Sportzentrum.

Cricket
Von 1898 bis 1908 trug der in diesen Jahren existente London County Cricket Club seine Spiele im Stadion aus. Der Verein hatte viele damalige Weltklassespieler in seinen Reihen und spielte von 1900 bis 1904 in der ersten englischen Cricket-Liga. Nachdem die Geldgeber ausstiegen, wurde der Klub 1908 aufgelöst.

Basketball
Im Sportzentrum befindet sich eine Basketball-Halle für 3.500 Zuseher. Derzeit spielt die Mannschaft London City Royals aus der höchsten britischen Liga in der Halle. In früheren Jahren war sie auch die Heimspielstätte der London Towers sowie der Basketball-Mannschaft von Crystal Palace.

Motorsport
Der Crystal Palace Race Circuit war Hauptbestandteil des heutigen Areals. Teile der Rennbahn sind heute noch im Areal sichtbar. Die Rennstrecke wurde 1927 eröffnet. Das erste Rennen für Motorräder fand am 21. Mai 1927 statt. Die Strecke war 1,6 km lang und ging durch den Park. Bis zum Abriss 1974 wurden Formel 2, Formel 3 und nicht zur Weltmeisterschaft gehörende Formel-1-Rennen auf der Strecke ausgetragen.

Weblinks

 visitlondon.com: Crystal Palace National Sports Centre (englisch)

Einzelnachweise

Leichtathletikstadion im Vereinigten Königreich
Fußballstadion in London
Fußballstadion in Europa
Rugbystadion in England
Cricketstadion in England
Sporthalle
Sportstätte in London
Grade-II*-Bauwerk in London
Bauwerk im London Borough of Bromley
Umgenutztes Bauwerk in London
Sportpark
Sportstätte für Badminton in England
Baugruppe (Städtebau) in England
Baugruppe (Städtebau) in Europa
Sport (London Borough of Bromley)
London Monarchs
American-Football-Stadion in England
Sportstätte für Basketball im Vereinigten Königreich


We are India's leading Exporter and Manufacturer of Chicory & Malt Products and its Value added products. These products are known for their purity, freshness and long shelf life.
Originated in the year 2011, in Atrauli, (Uttar Pradesh, India), We "RK Agroexport Private Limited" are engaged in manufacturing & Exporting the finest quality range of Value added Chicory products like Chicory Powder / Instant Chicory Powder, Liquid Chicory/ Roasted Chicory Extract, Dried Chicory Cube, Roasted Chicory Cubes, Roasted Chicory Grains. Our Product Range also includes Malt Extract Powder & Malted Milk Food Manufactured at our state of art Vacuum Drying Plant. The offered range of products is processed using the advanced technology under the guidance of our skilled professionals in strict conformity with the international quality standards and high hygiene levels. We have a team of quality control experts who deeply analyze our entire range on various parameters to make sure that we are offering the best products. Our products are highly appreciated among our clients for their precise composition, purity, long shelf life, freshness, high nutritional value and rich in taste. In addition to this, our products are provided in varied packaging options as per the diverse requirements of clients. We also have a facility of Contract Manufacturing for Spray Dried & Vacuum Dried food Powders.
Certificate of Recognition. GOVERNMENT OF INDIA Recognized One Star Export House.
Member of Indian Industries Association.


text:
Q: Append same number of
* as the value of variable In my case i have a mysql database with some content from a page. I have function on a page to add more
 to the database, basically it just add 1 to the number in database.
On another page i would like to display the list, how do i add the same number of
as the number of a variable made by the php?
var number_of_items = 6; // Printet by the php

$('.list_container').append('

'); // 6 times

I then want to append 6 times or what wver the number is.
How do i do this?

A: Try a neat little hack using Array.join()
$('.list_container').append(new Array(number_of_items + 1).join('

'))

Demo: Fiddle

A: try
for(i=0;i<number_of_items;i++)
{
  $('.list_container').append('

');
}

A: use:
var html = [];

for (i = 0; i < 5; i++) {
   html.push('

');
}

$(".list_container").append( html.join('') );

A: Try with the easiest way.
for(var i=1; i <= number_of_items; i++)
{
  $('.list_container').append('

');
}

A: A for loop it's the simplest approach:
for(var i = 0; i < number_of_items; i++)
    $('.list_container').append('

');

By the way, you have a lot of options, for example while loops and array joining.
Take a look to other answers

redpajama_set_name: RedPajamaStackExchange


text:
While buying tomatoes today at the FRESHFarm market near the White House, I met a homeless man named Martin, who was selling newspapers and waiting to go to a drug and alcohol treatment program in West Virginia.
I had seen Martin on previous trips to the market but didn't say more than "Hi!" or smile at him. Today, I bought a newspaper from him and we started talking. Martin told me that as a vendor for Street Sense newspapers he is similiar to a self-employed subcontractor. That means that when I buy a newspaper I am investing in him and Street Sense.
I told him I had seen other people around town, especially near the Metro stops, selling Street Sense, but I didn't really know much about it. Martin said that people usually think that he and others selling the newspapers go to a central office somewhere in DC to pick up free newspapers and then the homeless people sell them to make money. That's not the whole picture.
Martin purchases his own newspapers upfront for 35 cents/an issue to cover publishing costs and he sells the papers for a suggested donation of $1. This means that when a newspaper is bought for $1, that 35 cents of it repays Martin for his initial purchase. The remaining 65 cents is Martin's profit that he uses to support himself. The average vendor can earn about $45 a day.
I was curious about Martin's story because I know life can present changes quickly and I wondered how he had gotten to this place. I also know it takes an inner strength to live life on the streets and to stay clean and heal yourself of drugs and alcohol.
Martin said he is 40 years old and has a 20-year-old son. He said he has a mother, a brother and a sister who live in the area "but they have lives of their own." He told me he once worked in a law firm many years ago as the company's debt collector. He was hurt in a car accident and wanted to take more time off than the company allowed, so he was laid off. Martin said that's when his life totally unraveled and the drinking and drugs "helped me forget reality."
He has lived in shelters for years, just finished a 30-day rehab program at another facility and is now enrolled in a another program at So Others Might Eat (SOME). The SOME program involves Martin going to West Virginia for 90 days of drug and alcohol rehabilitation and extensive support treatments. He was supposed to leave for West Virginia this week but he had to go to the dentist today to have a tooth removed. Martin said he is grateful to be in the SOME rehab program (which paid for his dental work) because after he completes the rehab program, SOME will also help him find transitional housing and then eventually his own apartment.
I asked him what keeps him going when times get really tough. "I have discouraging moments," Martin said, "but I really can't imagine quitting on life itself."
Martin quietly added: "When people consistently see a person living on the streets, don't assume that it is easy to get it back together. Once you have lost everything it is very difficult to get back to mainstream living."
I thanked Martin for his time and wished him good luck. I told him when I come to the market next week that I hoped I wouldn't see him here. He said next week he hoped to be in the mountains of West Virginia following his rehab program.
On the way back to my office I thought about how I had gone to buy fresh veggies but learned about another person's journey. Martin is remarkably resilient, constantly trying to stay clean and never giving up on himself. I hope his life continues on its present course.
Now when I see someone in a neon vest selling Street Sense newspapers on the streets of Washington, DC, I'll know how these people are working a program and that buying a newspaper can help change a life.
Labels: alcohol, drugs, homeless, jobless, martin walker, rehab programs, selling newspapers, shelters, so others might eat, some, staying clean, street sense, vendors, west virginia


Certified copies of birth certificates are available through this office for all Montana Counties. Genealogy copies are available for Flathead County only. Certified copies are $5.00 each, and may be obtained at the Clerk and Recorder's Office in the old Courthouse, at 800 So. Main Street , or by mail. Anyone requesting an informational or certified copy of a vital record must present a valid ID.
The application to request a birth certificate thru the mail is available at the link below. Please complete the application and mail it to 800 S. Main - Room 114, Kalispell, Montana 59901.


BALTIMORE – UMBC softball launched three home runs in a 6-1 victory against Hampton in the final game of the 10th annual UMBC Dawg Pound Invitational at the UMBC Softball Stadium on Sunday afternoon. The Retrievers' head coach Joe French earned his 800th career coaching victory with the win.
The Retrievers took three-of-four on the weekend to improve to 17-6 on the year, French's second best start to a season during his tenure with the Retrievers, behind only the 2006 season. Hampton falls to 9-12.
UMBC jumped out in front 1-0 in the bottom of the first with a two-out solo home run to left center from junior Taylor Hall (Cosby, Va./Cosby). The round tripper was the 19th of her career, moving her into a tie for ninth with Stevie Shore ('06) on UMBC's career home run list.
The Retrievers posted back-to-back singles from Hall and senior Chelsea Bertoglio (Laguna Hills, Calif./Laguna Hills/Saddleback College) in the bottom of the fourth inning. Freshman Jaclyn Buckley (Voorhees, N.J./Eastern Camden Regional) launched her second home run of the season with two outs to extend UMBC's advantage to 4-0.
The Retrievers used their third long ball of the day to add two more runs to their advantage in the bottom of the fifth. Freshman Kelly Lane (Albany, N.Y./Colonie Central) led off the inning with a single and pinch hitter Megan Sauble (Glen Burnie, Md./CCBC-Catonsville) drilled her second blast of the year over the fence in right center.
Hampton posted three hits in the first six innings of the contest, but were able to string together three hits and a fielder's choice in the final frame to score its only run of the contest against starting pitcher Jessica Holte (Ashland, Va./Atlee). Holtee struck out a season-best seven batters en route to her 11th victory of the season, becoming the fastest Retriever in program history to reach 11 collegiate victories. She is now tied for seventh with Melanie Scharf ('94) on UMBC's freshman wins list.
The black and gold score six runs on seven hits versus Hampton's pitcher Jecholia Pratt.
The Retrievers return to action on Friday, March 21 for the first day of the UMBC Spring Classic at the UMBC Softball Stadium.
-Head coach Joe French has been a head coach in softball, women's basketball and tennis during his 24 year career. French continues his quest for his 600th victory at the helm of UMBC, he currently sits at 588.


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Featured Reviews, VOLUME 3
Featured: Oxford International Encyclopedia of Peace [Vol. 3, #10]
March 19, 2010 5:12 pm Views: 39
The Oxford International Encyclopedia of Peace.
Nigel Young, Editor.
Reviewed by Chris Smith.
The Oxford International
Encyclopedia of Peace.
Hardback: Oxford UP, 2010.
Buy now: [ Amazon ]
As followers of Christ, we are called to be peacemakers, and part of our education as disciples of Jesus is learning the things that make for peace. Thus, it has been exciting to see Peace Studies emerge as an academic discipline over the last three decades, and with the rise of Peace Studies come reference works that assist and propagate research. And now The Oxford International Encyclopedia of Peace (OIEP), published earlier this year by Oxford University Press, will undoubtedly reign supreme for many years as the key reference work for Peace Studies.
The four volumes of the OIEP represent a mammoth undertaking; its 850+ articles span over 2700 pages and were collected over a period of more than five years. The work begins with a brief foreword by the Dalai Lama who praises the work as a "scholarly but accessible reference work [which] will enable many of us to learn from the great ideals and struggles for peace over past centuries, and it will be a valuable resource for teachers of peace and for policy makers" (xix).
Also, included in the prefatory materials is a twenty page timeline of "Peace in History" – stretching from the Treaty of Kadesh, "the first recorded peace treaty" between The Egyptians and the Hittites in 1258 BCE, all the way through Barack Obama's recognition as the Nobel Peace Prize winner in 2009. Each entry in the encyclopedia is complete with a hefty list of works for further reading on that topic. The OIEP concludes with almost 100 pages of key documents on peace from the modern era (all but three of these documents were penned within the last 100 years), and a thorough index of key terms and people.
Editor Nigel Young observes in the encyclopedia's introduction that this work intentionally includes "both 'negative' entries (on preventing or ending war or violent conflict) and 'positive' entries (on achieving a more cooperative, harmonious community)." Negative entries in the OIEP include topics such as "Arms Control and Disarmament," "Conscientious Objection" and "Women Strike for Peace," while positives entries include "Deep Ecology," "Open Space Technology" and "Sustainable Development." Young also notes that the editorial team has intentionally limited the number of biographical entries, as well as those on specific organizations – choosing instead to describe persons and organizations within more general entries (e.g., the civil rights movement). Thus, I found the index to be an invaluable tool in searching for references to specific individuals and organizations.
Although the OIEP takes a broad and pluralist approach, the Christian tradition of peace is well-represented here. There are, for instance, entries on all three of the major "peace church" traditions: Church of the Brethren, Mennonites, and the Society of Friends (Quakers), as well as entries on individual Christian peace advocates like Dorothy Day, Lucretia Mott, Leo Tolstoy and Martin Luther King, Jr. One also finds several historical entries related to Christianity (e.g. a brief entry on "Early Christianity and Antimilitarism"), as well as superb introductory pieces on "Christian Ethics and Peace" and "The Christian Peace Testimony." Although they did not merit their own entry, I was pleased to find a handful of references throughout to the Christian Peacemaker Teams.
The OIEP offers a powerful reminder that there are a host of ideological motivations for pursuing peace. Peacekeeping, for instance, is very different from peacemaking, and there are a host of political, social or religious narratives that undergird the pursuit of peace. Church communities shaped by the sacrificial love of Jesus Christ, are very different than the idealistic vision of modern liberalism, through which peace is believed to be attainable through reason and rational behavior. Some forms of peace are more sustainable than others, and in our fallen world most, if not all, movements toward peace eventually get corrupted, but the stories of such movements live on long after they have died off or become irrelevant, and these stories serve to inspire new generations of peacemakers in ways that often expand the scope of the original peacemaking vision. As people who believe that God is at work restoring shalom to all parts of creation – human and otherwise – works like the OIEP can be understood as painting a broad picture of God's work within human history toward the restoration of shalom.
Therefore, I highly recommend the OIEP, as an invaluable resource for church, school, university or seminary libraries; it is the sort of resource that not only reminds us of the manifold ways in which God is guiding humanity and all creation toward shalom, but it also energizes our imaginations toward faithfulness to our calling as peacemakers. Not only does it introduce a vast number of peace-related movements and ideologies, it also points us in the direction of other pertinent resources for us to seek out in order to assist our reflection on any given topic. The OIEP is the essential reference work in the area of peace studies, and as such it should be kept close at hand by those of us who seek to follow Jesus as peacemakers in a world that is still very much ensnared by the myth of redemptive violence and in which war, social, ecological and other sorts of conflict are still prevailing and defining forces.
vanThanh Nguyen - What Does the Bible Say About Strangers,…
A Just Peace Ethic Primer - Eli McCarthy, Editor - Review
Lorna Gold - Climate Generation - Review
Henry Vaughan - Seven Favorite Poems !
Tags: History, Oxford University Press, Pacifism, Peace, Peacemaking
← Review: Writings on Reconcilia ...
Poem: "Easter Wings̶ ... →
todd walters
Can't wait to get my hands on a copy.
Congratulations to Nigel and Antonia, and all who have helped in the successful completion of this endeavor. peace – todd


James Maynard Nelson III passed away on Thursday, April 11, 2019 at the age of 67. James was born on May 2, 1951 in Helena, Montana. He was the oldest of eight children born to James and Patricia Nelson. He graduated from Helena Senior High in 1969 and attended the University of Montana studying business and accounting. He worked as a glazier at the family owned glass business. In his spare time he enjoyed writing and reading and spent many hours at the library. He had a great sense of humor and enjoyed the company of family and friends.
He is preceded in death by his parents James and Patricia Nelson. He is survived by his seven siblings; John Nelson, Mike (Stephanie), Mari Holms, Julie (Brett) Albertson, Catherine (Jack) Dartman, Stephen (Lynn) Nelson and Johanna (Andrew) Steele. He is also survived by an aunt in Butte, Marie Hubley and cousins Bernie (Kathy) Hubley, John (Becky) Hubley, Mary (Mark) Berg, Melody and Ralph Eisenbise.
A private family service is being planned at this time.
Miss Mari, I am sad to hear of your brothers passing.
So sorry to hear of Jim's death. Losing a sibling is so hard. Just seeing his picture brought back memories of times at your home…just like ours there was always lots going on between everyone. I know Jim will be missed by you all. Sending a hug and wishes for comfort yo you.
I had many good times –and of course good laughs — working with Jimmy and all of the Nelsons in the late 70s and early 80s at the Helena Glass.
To Kate and other family members, So sorry for your loss, Jim had such a good sense of humor, It was a pleasure to be able to work with Jim when he was going through a difficult time, And to be able to be there for Kate as well. You Both will be forever in my heart.
Please accept my condolences and my prayers as you proceed through this difficult time. May the love of God, friends, and family continue to keep you supported and strong. Your are loved.
So very sorry to hear of Jim's passing. I remember sharing fun times with your family as we were growing up, and I send my sympathy to all of you.
So sorry to hear about Jimmy's passing. I haven't seen or heard much from him over the last few years, but will never forget our High School and College days. I am sure he will be missed. By the way, when did he sleep? As a college roommate he just paced floor all night long.


Shivani Dogra has a wonderful eye for all things interior. Her deep knowledge and respect for India's artisan traditions with a nod to our modern lives is a combination that makes for unique spaces to be proud of and to be lived in. She's a joy to work with and I recommend her design services wholeheartedly.
Our new office in Bangalore was both lovely and odd. We had found an old but beautifully preserved bungalow with ivy covered walls overlooking a beautiful garden. The rooms, however, were several, and smallish.
My brief to Shivani was a reflection of how we thought of ourselves as a company. We did not want a very corporate look. On the other hand, we also did not want to go the ultra-casual, bean-bags-and-TT-table-route. We took beauty very seriously, but we had a limited budget. We love what Shivani has done. We love it each day that we work in this office. And invariably, visitors to our office have loved it too. The pictures are proof. What the pictures don't show is all the effort and toil that Shivani put into making this happen. The obsessive attention to detail, the endless hours supervising the contractors to get just the right colour on a wall, and the miles of trudging up and down second hand furniture markets to choose chairs and desks that would suit her vision. When we do move to a larger space, as we must at some point, I have no doubt as to who my first choice will be for designing the interiors.
We wanted a quick makeover for our Living and Dining space and hired Shivani and her team to do the job. The transformation in just a month was incredible and surpassed our expectations! The colours were perfectly balanced and we love all the pieces of furniture and art that were sourced specially for us. There was so much attention to detail– every picture frame and piece of art in our house was carefully selected, the fabric was specially bought from a variety of places all over the city, because every thing in the space had to go perfectly together. We were happy to have someone pay so much attention and take so much effort to do our place. We continue to enjoy the beautiful and functional space they worked so hard to give us. Our guests love visiting!!
4) complete the project on time and within budget.
Shivani brought a tremendous amount of creativity and suggested ideas/layouts/colors that we never thought of or imagined before….and these out-of-the-box ideas were comfortable, that we never regretted implementing any of them. It's very satisfying to walk into our house and feel like the space truly reflects our unique personalities, and not some design catalogue.
All our friends/visitors immediately comment on the beauty , elegance and richness of our interiors, ask how it all came together and start considering hiring a designer themselves. Shivani was incredibly patient with me to make decisions, find a time to meet, and even helped oversee furniture deliveries, paint jobs, handled tailoring, returns, and installations. Honestly, we couldn't do it on our own without her expertise, hard work, professionalism and kindness. She knew where to push and where to evolve her own creativity to fit our interests and taste. AND we stayed within budget. We now LOVE every room in the house and highly recommend Shivani Dogra to anyone looking for creative, vintage and unconventional interpretations of space.
Shivani has impeccable sense of aesthetics and colour combinations. With knowledge and an eye for sourcing furniture and soft furnishings, she was able to give our home the warm rustic natural look that we wanted. Her sincere and hardworking nature make her an ideal choice to give your home a whole new look.
It was a first time that we used an interior decorator. Our brief was to re do our living room with bright colours and the other rooms would complement them with bright colours. We wanted colour and comfort and dressing up of the bare walls. The design involved replacing an older floor, painting, minor changes to the structure and decoration. Shivani was steadfast and firm and she patiently listened to our fears and constrained herself to our budget. Shivani was very patient in each decision taken and made as aesthetic and comfortable a space as she could. She detailed all the additional pieces we could buy to enhance the home. Her aesthetic sense is very gracious and reflects beauty and life into her work. She is very passionate and is generous with telling us about her special places to buy additional pieces. Her judgement made a big difference it streamlines our thinking and helped us to build a home on a budget. I would definitely recommend her work as its t's very workable and she guides you expertly if you are confused.
Shivani worked on two Briar Tea Bungalows, Stanmore and Sirukundra. Both Bungalows had different styles of architecture which her designs did credit to. In Sirukundra Bungalow she created an ambience inspired by botanicals and the natural history of Valparai. Sirukundra is now filled with colours in every hue, florals and natural materials– a delight to all that visit! In the other, Stanmore she decorated the space with well researched historical plantation influences. She recovered old painted wood fireplaces and mouldings to reveal the wood underneath and used utmost care to look into small details such as switch boards and accessories. From cutlery to crockery and wall hangings every details was carefully looked into and chosen. The hard work and the transformation behind these bungalows was extraordinary. All our visitors and guests enjoy their stay and compliment the beautiful ambience created. We look forward to future collaborations with Shivani.
Shivani was part of a team that helped decorate 6 old classroom blocks on the Scindia School Campus. Each block was first restored by Ajaydeep Singh Jamwal and Neeraj Bhagat to whose meticulous work, she added another dimension. Her designs added colour, style, life into the old buildings in keeping with their stately structure. The transformation from old to new was tremendous and hard work executed by the three is evident in every studio. The work received great deserved praise during the inauguration– appreciated by visitors, guests, students and staff alike. Today they offer a comfortable and beautiful stay to all who visit.


text:
Q: Uploading files to the server using HTML5 I would like to know how can I upload a file after selecting it using HTML5 in that way:
<input type="file" .... />

The line above gives you the option to SELECT a file, now I need to upload it to the server.
Since I don't know the answer I'll tag both php and Javascript.

A: Here is the code of Upload file in PHP
index.php

<form action="upload_file.php" method="post"
enctype="multipart/form-data">
Filename:
<input type="file" name="file" id="file">

<input type="submit" name="submit" value="Submit">
</form>

upload_file.php
<?php
if ($_FILES["file"]["error"] > 0)
  {
  echo "Error: " . $_FILES["file"]["error"] . "
";
  }
else
  {
  echo "Upload: " . $_FILES["file"]["name"] . "
";
  echo "Type: " . $_FILES["file"]["type"] . "
";
  echo "Size: " . ($_FILES["file"]["size"] / 1024) . " kB
";
  echo "Stored in: " . $_FILES["file"]["tmp_name"];
  }
?>

A: You need an upload script like this one :
<?php
if ($_FILES["file"]["error"] > 0)
  {
  echo "Error: " . $_FILES["file"]["error"] . "
";
  }
else
  {
  echo "Upload: " . $_FILES["file"]["name"] . "
";
  echo "Type: " . $_FILES["file"]["type"] . "
";
  echo "Size: " . ($_FILES["file"]["size"] / 1024) . " kB
";
  echo "Stored in: " . $_FILES["file"]["tmp_name"];
  }
?>

Check this link (http://www.w3schools.com/php/php_file_upload.asp)


text:
DeMar DeRozan Admits It Was Hard To Pass On Signing With Lakers
Kelvin Kuo-USA TODAY Sports
VIDEO: I'm Thankful For ________ (Lakers Edition!)
One of the most sought-after free agents on the open market was Los Angeles native DeMar DeRozan. The former USC star had made a name for himself as the face of the Toronto Raptors franchise and had the opportunity to return home to play for the team that he loved growing up, the Los Angeles Lakers.
With the Lakers hoping to land a big-name free agent, DeRozan fit the bill as a hometown player and a two-time All-Star. Although there were rumors of DeRozan strongly considering returning to Los Angeles to sign with the Lakers, the then-26-year-old quickly re-signed with the Raptors after hitting free agency.
Although DeRozan decided to stay with the team he's played with throughout his entire NBA career, the NBA veteran from Compton admitted it was difficult not to return home in an interview with Marc J. Spears of The Undefeated:
You could have gone home in free agency. You could have gone to the Lakers or the Clippers. Was it hard for you to say no to going home?
Yeah, of course. At the end of the day, the Lakers are the Lakers. I grew up a Lakers fan. Kobe [Bryant] was my favorite player growing up. I didn't miss a game as a kid. Just to have the opportunity was amazing. I watched one of my favorite players create a legacy of his own and leave his mark there.
He left his own mark there. It will always be there. I want to leave my own mark in Toronto.
Since making his decision to stay in Toronto, DeRozan has been a man possessed for the Raptors during the 2016-17 NBA season. DeRozan has taken his game to the next level averaging 30.9 points per game ahead of the Raptors' showdown with the Houston Rockets on Wednesday.
DeRozan sits only behind superstar Russell Westbrook (31.8) of the Oklahoma City Thunder in the race for the scoring title. Ironic considering both players are from Los Angeles, have both been linked the Lakers consistently over the past few years, and went to USC and UCLA respectively.
Regardless of DeRozan's decision to remain with the Raptors, the Lakers have gotten off to an impressive start to the season. New head coach Luke Walton has this team back on track with the entire team buying into his system with a resilient spirit that hasn't been seen from this team in years.
Byron Scott On Jason Kidd: 'He Was Kind Of Known As Being An A–hole'
Los Angeles Lakers head coach Byron Scott's first head coaching tenure was…
VIDEO: Lakers PG D'Angelo Russell Working On His Handles With Robbie Haught
The Los Angeles Lakers have an exciting offseason approaching, starting with the NBA Draft on June 23 and NBA free agency beginning on July 1…
Nathaniel Lastrapes
Lakers Rumors: Dennis Schroder Trade Completed With Future Contract In Mind
Los Angeles Lakers vice president of basketball operations Rob Pelinka made it clear the organization would not…
Matt Peralta
VIDEO: Byron Scott's 3 Favorite Things About Kobe Bryant
http://youtu.be/6uea8Uemaus Head coach Byron Scott has a tough task ahead of him…


text:
OK Go releases colorful new music video for "The One Moment"
By Ned Ehrbar
November 23, 2016 / 2:32 PM / CBS News
Viral video maestros OK Go have one-upped themselves once again with their latest on-camera stunt, a super-slow-motion video for the song "The One Moment."
The clip, released Wednesday on the band's Facebook page, took just 4.2 seconds to film -- but when it's slowed down it reveals action and colorful explosions timed to the song's tempo and changes.
OK Go defies gravity in new video "Upside Down & Inside Out"
"The song 'The One Moment' is a celebration of -- and a prayer for -- those moments in life when we are most alive," a statement from the band posted to its official website read. "Humans are not equipped to understand our own temporariness; it will never stop being deeply beautiful, deeply confusing and deeply sad that our lives and our world are so fleeting.
"We have only these few moments. Luckily, among them there are a few that really matter, and it's our job to find them. We had no idea when we wrote the song that we'd be releasing its video in such a critical moment for our nation and the world. It's one of those moments when everything changes, whether we like it or not, so the song feels particularly relevant."
OK Go - The One Moment - Official Video
Ladies and gentlemen, please enjoy our new video for "The One Moment." A million thanks to our partners at Morton Salt #WalkHerWalk.
Posted by OK Go on Wednesday, November 23, 2016
First published on November 23, 2016 / 2:32 PM
Ned Ehrbar
Ned Ehrbar is an entertainment producer for CBS News.
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People who love history just always seem to Babylon.
One of the amazing parts of travel is that wherever you go it brings you closer to history. At Trepic we've gathered some of the most unique traces of famous empires to explore on your adventures.
El Tepozteco temple stands the test of time as a hidden gem of the Aztec Empire. Drive three hours outside of Mexico City through the mountains and you'll arrive at Tepoztlan. Regarded as a magical city walk through the cobblestone streets and covered markets to end at the base of the crumbling stairs snaking up to the Aztec temple. Upon arrival you'll be able to survey the entire valley. After you head down sooth your tired soul with a blended mojito, a speciality of the area.
Visit Berlin to get a chance to see the reconstructed Babylonian Isgar Gate, complete with stunning blue and gold tiles. Excavated in the 1930's and brought to Berlin to be reconstructed the Ishtar Gate found its new home at Pergamon Museum in Berlin. You can imagine walking along the hall lined with fearsome creatures like lions and dragons up to the Babylonian Empire. Constructed by King Nebuchadnezzar II in 575 BCE, it is the eighth gate to the city of Babylon. You can also find a reconstruction in Iraq in a near to where it was originally built.
The Taj Mahal is an iconic feat of architecture created by Shah Jahan in 1632 as a memorial for his wife who died in childbirth. It stood the test of time to become a beacon of the Mughal Empire in Agra. Built of white marble and covered in precious gems the Taj sits at the end of a four part garden, symbolic in Islam as paradise. One of the wonders of the world, the Taj Mahal attracts romantics and history buffs alike from all over the world to take in the transcendent beauty first hand.
Possibly the most well known empire, the Roman Empire, has remnants of its conquests scattered across Europe, the Middle East, and Northern Africa. With classics like the Colosseum and the Pantheon, The Library of Celsus in Turkey is one of their more under the radar architectural gems. However at the time (completed in 117 CE) the Library of Celsus was one of the largest and most impressive libraries in the world. Spend an afternoon learning about life during its success and viewing the crumbling architecture.
To discover more exciting destinations personally curated for you, download the Trepic app from the app store today.
Sign up to be one of the first notified of our much anticipated launch!


Gardner Elliot (Asa Butterfield) just wants to be on Earth. Gardner is a 16-year-old boy who lives on Mars. His mother, Sarah Elliot (Janet Montgomery), an astronaut on a four-year trip to Mars, finds out she's pregnant shortly after they arrive. When she dies during childbirth, Gardner is left in the care of a team of scientists. We never learn what became of the other astronauts on the trip who knew the truth about how Sarah died, a truth NASA kept from the public citing a malfunction instead. After we learn of her passing, the movie cuts to Gardner at 16 who is a bit mischievous and desperate to be around someone who is his own age.


text:
Frank Andy Montieth Herrera, född den 11 januari 1985 i Palma Soriano, är en kubansk basebollspelare (pitcher) som tog guld för Kuba vid olympiska sommarspelen 2004 i Aten.

Referenser

Noter

Kubanska basebollspelare
Kubanska idrottare under 2000-talet
Spelare i Serie Nacional de Béisbol
Kubanska olympiska guldmedaljörer
Olympiska guldmedaljörer 2004
Tävlande vid olympiska sommarspelen 2004 från Kuba
Tävlande i baseboll vid olympiska sommarspelen 2004
Födda 1985
Levande personer
Män