text:
Cleveland SOHO Media
"The Witchy Witch of Rolling Oaks Farm"
by Allen Leonard
Rolling Oaks Farm spread peacefully near a wide valley beyond the quaint town of Anderville. Rustic and weathered, the old farm nestled among tall trees that provided shade from hot summer days and protection from cold winter breezes. Nearby wide fields bordered a creek that meandered through the expansive property. For years the spacious old homestead with rows and rows of colorful flowers growing beside the long driveway had been the base of stories from the gossip-ridden community. Olga Landsworth, the old woman who lived there, was often the subject of whispered rumors of witchcraft and religious cults on the farm. "That's where the Witchy Witch lives!" Crissa said as she walked home from school with two friends. "How do you know?" Sarah, one of her friends asked. "Well it's true, she's a witch!" Argued Crissa. "We should never spread rumors about someone." Sarah answered politely. "Everyone says it's true!" Crissa responded raising her voice. "Such as?" Questioned Sarah. "Kelly and Francine and Amanda!" "That's who!" Crissa added sarcastically. "The whole town has known it for years!" She defended her accusation as they walked past the expansive farm. "This town gossips about everything, even you and I!" Sarah exclaimed. "Well I'm gonna find out right now!" Sarah Said. "For once and for all!" She crossed a ditch and headed towards the yard leading to the old house, walking past a rock garden and some rose bushes that had not been pruned in years.
A picket fence lay broken near the house and the late afternoon sun pushed shadows through the tall trees in the yard. Sarah slipped between some bushes and boldly approached a latticed window. "Ouch!" She whispered as a rose thorn pricked her hand. "Oh darn!" She whispered nervously as her cotton shirt became entangled in the sharp branches. She pushed the prickly bushes away and peered cautiously into the window. In front of her lay the answer to thousands of whispered stories that had echoed around the little town for years. Inside, an old woman knelt before a small painting that was highlighted only by candles. Sarah took a deep breath as she peered in quietly at the mysterious scene. From the room came a soft melody sung faithfully by the praying woman. It was harmonic and serene, almost mysterious and from time to time she would look upward asking for recognition from the heavens. Sarah watched the woman paint for several minutes and then slipped silently away and walked quickly across the un-mown yard. "Well?" Asked Crissa as Sarah caught up with her friends. "It looked like she was praying." Sarah answered out of breath as they walked quickly down the long dusty road. "She was what?" Crissa demanded. "Kneeling and praying and painting." Sarah answered. "Praying and painting?" Crissa said attempting to lend credibility to the rumors. "And kneeling?"
"Yes, and singing or something!" Sarah continued catching her breath. "Praying or something...Hmmmm!" Crissa said. "Then she is a Witchy Witch!" She continued. "Just as everybody says!" Sarah remained quiet as they walked, thinking about what she had just seen in the old farmhouse. "Let's not rush to any conclusions." She said solemnly. "But you just said she was a witch!" Crissa snapped back. "I said she was praying!" Sarah replied a little angry at the accusation. "Well everyone says she's strange." Crissa argued. "She's a witch!" The girls continued walking, each containing their thoughts without speaking. Then Crissa started walking slower and finally stopped. "You've just been cursed by a witch!" She stared at Sarah. "Oh come on! Get real!" Sarah said surprised at the accusation. "No, I mean it!" Crissa yelled. "Don't come near me!" "What are you saying?" Sarah asked totally surprised. "You've got the curse of a witch in your heart." Crissa said backing away. "You shouldn't have gone in there." "Don't start that kind of rumor!" Sarah exclaimed. "I'm telling everyone!" Crissa yelled as she ran from Sarah. "Go ahead, see if I care!" Sarah hollered as Crissa ran away down the road.
The next day in school Sarah was surprised at the distance her friend kept from her.	When she walked over to her she backed up and quickly walked away. Sarah went alone to homeroom and sat quietly while everyone seemed to buzz with conversation.	"Hey Witchey!" Said Jason who sat in the next row. "Heard you're the new witch in town." "I guess I am!" Sarah answered quietly. "Don't pay any attention to it." Jason whispered. "Crissa's just jealous of you." "It still hurts!" Sarah said somberly. "We've been friends since grade school, and she's never acted like this before!" "Friends don't spread rumors about someone!" She added. Sarah walked home alone that afternoon, while Crissa and some other girls had a good laugh on her. They yelled, and hollered and called her "Sarah Witchy Witch." It was very disappointing and Sarah became determined to fight back. "If I'm Sarah Witchy Witch, then I'm going to be a real witch." She walked to the old farmstead beyond the edge of town. "I'm going to find out just what it takes!" She whispered to herself. The lilac bushes lining the driveway were in full bloom of violet and white flowery sprays that filled the air with a sweet scent.	"Mmmmmmm." She whispered as she inhaled a deep breath of the fresh flowery fragrance. "I don't remember any lilacs last night." Bam Bam Bam...she knocked loudly on the door.
She waited for a few moments, and then knocked again. Slowly the huge door swung open and a frail old woman peered out. "Hello, I'm Sarah Johnson. I came to ah, learn about being a ...!" "Yes child, what is it you want?" The old woman asked in a soft frail voice. Sarah caught herself and changed her question. "I was wondering if you needed any yard work done?" She said half apologizing. "Oh yes, my dear! My yard is a mess!" The old woman smiled. "And no one seems interested in a little work here." Sarah was invited in and offered fresh chocolate cake. "So your Sarah Johnson!" The old woman asked. "From down the road?" "Yes!" Sarah said as soft cake was sliced. "Such a nice name dear!" "And your Olga Landsworth." "Yes!" "You have a strong accent." Sarah said amused. "I was born in Poland." Olga answered with a somber tone in her voice. Sarah got along good with the old woman, and they walked out to the yard where Olga pointed out what she wanted done. The following Saturday Sarah returned and worked hard cleaning the yard. From time to time Olga peered from a window and watched the industrious girl busy trimming rose bushes.
"Come and have a fresh roll." Olga called from the doorway. "You must be hungry my dear." Soon Sarah and Olga were visiting over fresh rolls covered with warm butter. It gave the young woman a chance to learn more about the person everyone considered a witch. "Do you know anything about witchcraft?" Sarah finally asked boldly. "Witchcraft?" Asked Olga somewhat surprised. "Yes, witchcraft!" Sarah answered. "Not really, I'm an artist." Olga said with a slight smile. "Painting is my passion." She added. "My writings are my life." "But you just said you were an artist." Sarah asked. "I write Icons." Olga said taking a sip of hot coffee. "I don't understand?" Sarah questioned. "You don't paint Icons my dear, you write them!" Olga smiled proudly. She led Sarah to the den, where a row of mysterious paintings rested on a long shelf. "These are some of my writings!" The old woman said proudly. Sarah looked closely at several of the Icons, carefully noting the solemn expression on the faces and the innocence of the paintings. "These are fantastic!" She exclaimed. "Thank you dear!" "I take art in school." Sarah added as she looked over more of Olga's work. "But these, why...they reach out and appeal to you."
"That's the intention." Olga smiled. "They must be genuine." Sarah listened while the old woman explained more about the Icons she had written. The patience needed to complete an authentic writing required sincere dedication, and Sarah was beginning to understand the rumors surrounding the quiet woman. "Where did you learn all of this?" She finally asked. "It's a long story dear." Olga said as she carefully straightened one of her unique creations. Sarah went back to work in the yard with a new opinion of the quiet old woman. Her thoughts roamed at the brief exposure to the art form she had just seen. The yard work became suddenly enjoyable and time passed quickly. The following week in art class she was greeted rudely by Crissa. "Is the Witchy Witch going to paint with her broom today?" Crissa asked with a laugh. "I might!" Sarah answered sarcastically. "My! We have a snippy witch." Crissa responded. "Yes, you do!" A very snippy witch." Sarah smiled as she walked past and went to her drawing table. That day a contest was announced for art students, and the prize was three hundred dollars and a scholarship to a prestigious college. Sarah knew everyone in class would participate, as well as students from around the region.
"Now you can put your broom to good use!" Crissa laughed as they walked from the room. Sarah did not reply, for she knew what she was going to do for the contest. Over the next several weeks she worked very hard cleaning Olga's yard. She asked the patient woman for advice on how to complete a writing for her art project. "Everything's done! I even pruned the roses." She said to Olga on a warm evening. "The yard looks wonderful dear." Olga answered. "You promised you would show me how to write an Icon." Sarah asked. The two of them walked into the ornate den and sat for a moment while Olga gathered her thoughts. The old woman was precise, and carefully explained the discipline and regimen needed to complete an Icon. It would require a dedicated spiritual effort and a special attention to detail. "Your spiritual life must be in place." Olga said. "And you must above all be genuinely humble!" "Your writing must reflect a caring heart and great simplicity." Sarah listened intently as Olga described the regimen and discipline needed to write an Icon. Now she understood what was happening when she had seen the woman kneeling in prayer through the window. Over the next few weeks Sarah worked hard on her writing. She ate very little, and then only cheese and some homemade wheat bread prepared from one of Olga's recipes.
During the day she greeted everyone with kindness, including the often-rude Crissa. Olga had given her an Akathist to memorize, which was to be sung over and over as she created. Each morning Sarah rose early, and prayed for one hour before starting her work. From time to time she went outside and whispered softly to the early morning sun. In time, her writing took form and reflected the sincere effort and hard work that was put into it. When she finished, she proudly took it to Olga. "It's truly genuine!" The old woman smiled. "It's not just a simple painting, but a reflection of your sincerity. It comes deep from your soul!" "Very well done for your first writing!" "I'm very proud of you." Sarah humbly accepted the praise, but she needed to know more about Olga and her Icons. "They should reflect hunger and innocence in their expressions." The old woman said in a sincere voice. "I tried my very best!" Sarah answered. "But I could not match the quality of your work." She added. Olga sat down and looked at the writing. She was still for several moments, and finally a tear slipped over her cheek.
"When I was five years old my family was taken to a prison camp." She looked over at one of her writings and then back at Sarah. "My dear father was torn from me by soldiers and I never saw him again." Olga walked to an Icon and briefly touched it. "This one is my tribute to my father!" She said with tears slipping down her face. "My sister and I stayed as close as possible to our mother." She continued. "But one day..." The old woman could not continue, but walked to a painting she picked up and held in her arms. "This one is for my mother!" She said through sniffles. "The last time I ever saw her a soldier was shoving a gun at her and calling her a "Witchy Witch." "A Witchy Witch?" Sarah asked surprised. "Yes, my loving mother was called a "Witch!" "Hmmmm!" Sarah thought to herself. Olga explained how soldiers dragged her mother away as she fought bravely to cling to her children. Her sister ran to help her mother, and neither of them were ever seen again. "An old woman wrapped a coat around me and held me in her arms for days." She said through choked emotions. "We nearly froze in a cold building." "She took charcoal and etched a writing of a Madonna on a wooden wall." Olga sighed. "Some how we survived." "I listened as she taught me about kindness and respect, and being humble!" She paused for a moment and then continued.
"I never forgot what she said to me!" "Even in those desperate moments she offered kindness and hope." "I painted these when I was just a little girl." She added somberly. Sarah remained quiet and listened. Olga had answered her questions about the old woman's quiet lifestyle. She was not a mean old witch as everyone claimed. The following day Sarah took her writing to the art contest where she proudly entered her Icon. "Look what the Witchy Witch dragged in!" Crissa loudly proclaimed. "It looks like it's been painted with a broom!" She laughed boastfully. Soon however, something happened, and the writing drew the attention of the judges, and many of the contestants. The painting immediately became the focus of the event. "This is incredibly well done!" Said one of the judges. "It's been some time since I've seen a work of this quality!" "It is indeed unique!" Added another official. "Whose initials are W.W.?" "The panel is going to award you three hundred dollars and an art scholarship." "It's my writing." Sarah said somewhat surprised as she stepped forward. "The Witchy Witch of Anderville High!" The judges and audience marveled over the unique artwork. "Do you have plans for the prize money?" A judge asked.
"Yes I do!" Sarah smiled. "I have a friend who needs her house painted!" She walked past everyone accepting congratulations. She could hardly wait for the ceremony to end so she could go to Rolling Oaks Farm and tell her good friend Olga what had happened.
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Business Finance - Banking - Money Investments Lao Economy Latest News
Unemployment Spirals Due To Covid-19 Outbreak
18/05/2020 18/05/2020 J&C Admin 757 Views
Source: Vientiane Times
The perennial challenge of unemployment in Laos has been further exacerbated by the Covid-19 outbreak as large numbers of people have been laid off from their jobs.
This has caused the unemployment rate to surge from the normal average of 2 percent to 25 percent at present. The unemployment rate measures the number of people actively looking for a job.
Many businesses ceased operation during the recent lockdown and some are still shuttered. These include processing and garment factories, construction material manufacturers, restaurants, shops, and businesses operating within and outside of special and specific economic zones.
This information was relayed by the Minister of Labour and Social Welfare, Dr Khampheng Saysompheng, on Thursday when speaking at a meeting of Asean labour ministers on the response to the impact of Covid-19 on labour and employment.
Although Laos has recorded only 19 confirmed cases of the virus, the risk of a widespread and severe outbreak still exists. Against this backdrop, the government has laid out measures to prevent the spread of the virus as specified in Prime Minister's Order No. 6 on increasing prevention and control measures and comprehensive preparedness to deal with Covid-19.
The global pandemic has severely impacted the economies of many counties, including Laos.
In addition to prevention and control measures, the government has introduced short- and long-term policies aimed at minimising the damage caused to the economy. This is intended to help businesses, especially small and medium enterprises, to continue their operations and drive the economy forward.
The ministerial meeting discussed efforts to ensure that all workers, including migrant workers, those laid off or furloughed by employers affected by the pandemic, are compensated appropriately by their employers and receive social assistance or unemployment benefits from the government where appropriate, in line with the laws, regulations and policies of respective Asean Member States.
It was agreed to help all workers infected with the virus to access essential healthcare and other medical support as necessary, and to prevent discrimination against infected workers.
The meeting also resolved to use digital technology for communication and consultation media amidst temporary restrictions of movement, so as to further regional cooperation and national responses to the impact of the pandemic on labour and employment.
Meeting participants agreed on the need to provide assistance to Asean migrant workers affected by the pandemic in each other's country or in third countries. This includes effective implementation of the Asean Consensus on the Protection and Promotion of the Rights of Migrant Workers, working towards their health, well-being and safety, as well as facilitating their movement and reuniting them with their families.
It was also agreed to further strengthen the effectiveness of active labour market policies at national and regional levels, occupational safety and health standards, and social protection systems through productive and harmonious social dialogue to retain employment, reduce the vulnerabilities of at-risk workers, and improve their resilience.
Pay Road Tax Or Get Stopped At The Border
Mining Slump, Improper Planning Blamed For Budget Tensions
← Travel Restrictions Lifted As More Lockdown Measures Eased
Students Return To School As Covid-19 Restrictions Ease →
ATMs in Laos
Foreigners To Pay More Income Tax
08/06/2011 30/07/2018 Stephan
Foreign Investors Allowed To Own Land in Laos

redpajama_set_name: RedPajamaCommonCrawl


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This clinic operates under a SLIDING SCALE model. This means that it MAY NOT be free depending on your income. You will be required to prove financial need in order to receive free services or services at a reduced cost. This is a health care center funded by the federal government. This means even if you have no insurance you can be covered. The center is also income based for those making an income. This health center can cover services such as checkups, treatment, pregnancy care (where applicable), immunizations and child care (where applicable), prescription medicine and mental and substance abuse where applicable. Contact them at the number provided for full details. Aaron E Henry Community Health Center Clarksdale is a Community Health Center. In order to get more information on this clinic, click on the icons below. You may be required to join for free in order to access full contact information.
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Aaron E Henry Community Health Center Clarksdale is a Community Health Center.
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Carl Friedrich started to program C++ when he was 16, couldn't stand it and turned to Python soon afterwards. He is a PyPy developer since the beginning of 2005. He studies mathematics, computer science and physics at the University of Heidelberg and works for merlinux on PyPy and other projects.


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Investing in 2019 means looking for growth at a late stage of the economic cycle. Our Investment Outlook 2019 identifies six key market drivers and risks that will be particularly important for investors next year.
The past year has been significantly tougher for investors than expected. A combination of economic and political disruptions boosted market volatility. In early 2018, fears of rising US inflation led to an upward shift in interest rate expectations which boosted the US dollar but put pressure on emerging markets in nations that depend on US dollar liquidity.
Trade tensions also escalated. Later in the year, worries over flagging growth in China and the Eurozone further increased risk aversion. Finally, earnings expectations declined in key sectors, a setback to the leading technology sector.
Going into 2019, we believe there are good reasons to believe that risk assets will once again find their footing. In our latest Investment Outlook, we argue that there are at least six key factors that should provide support.
Inflation should remain moderate, reducing the risk of major interest rate shocks while also suggesting the US dollar and other currencies should be more stable than in 2018.
Supported by limited policy easing, China's growth should prove resilient in the face of trade tensions while the more fragile EM correct their imbalances. Finally, we also expect political tensions in Europe to subside while technology and health care innovations continue to drive long-term growth and equities.
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text:
import Ember from 'ember';

import QueryBuilder from '../query/builder';

/**
 * Mixin for {{#crossLink "DS.Store"}}Store{{/crossLink}} to support
 * fetching models using projection.
 *
 * @module ember-flexberry-data
 * @namespace Projection
 * @class StoreMixin
 * @extends Ember.Mixin
 */
export default Ember.Mixin.create({
  /**
   *
   * @method query
   * @param {String} modelName
   * @param {any} query an opaque query to be used by the adapter
   * @return {Promise} promise
   */
  query(modelName, query) {
    Ember.debug(`Flexberry Store::query ${modelName}`, query);

    let promise = this._super(...arguments);
    return new Ember.RSVP.Promise((resolve, reject) => {
      promise.then((results) => {
        if (results && Ember.isArray(results)) {
          results.forEach((result) => {
            result.didLoad();
          });
        }

        resolve(results);
      }, reject);
    });
  },

  /**
   *
   * @method queryRecord
   * @param {String} modelName
   * @param {any} query an opaque query to be used by the adapter
   * @return {Promise} promise
   */
  queryRecord(modelName, query) {
    Ember.debug(`Flexberry Store::queryRecord ${modelName}`, query);

    return this.query(modelName, query).then(result => new Ember.RSVP.Promise((resolve) => resolve(result.get('firstObject'))));
  },

  /**
   * Finds all records for the given model type.
   *
   * See {{#crossLink "DS.Store/findAll:method"}}{{/crossLink}} for details.
   *
   * @method findAll
   * @public
   *
   * @param {String} modelName The name of the model type.
   * @param {Object} [options] Options.
   * @param {String} options.projection Projection name.
   * @return {DS.AdapterPopulatedRecordArray} Records promise.
   */
  findAll(modelName, options) {
    Ember.debug(`Flexberry Store::findAll ${modelName}`);

    let builder = new QueryBuilder(this, modelName);

    if (options && options.projection) {
      Ember.debug(`Flexberry Store::findAll using projection '${options.projection}'`);

      builder.selectByProjection(options.projection);
      return this.query(modelName, builder.build());
    }

    let queryObject = builder.build();

    // Now if projection is not specified then only 'id' field will be selected.
    queryObject.select = [];
    return this.query(modelName, queryObject);
  },

  /**
   * Returns a record for a given type and id combination.
   *
   * See {{#crossLink "DS.Store/findRecord:method"}}{{/crossLink}} for details.
   *
   * @method findRecord
   * @public
   *
   * @param {String} modelName The name of the model type.
   * @param {String|Integer} id Record ID.
   * @param {Object} [options] Options.
   * @param {String} options.projection Projection name.
   * @return {Promise} Record promise.
   */
  findRecord(modelName, id, options) {
    Ember.debug(`Flexberry Store::findRecord ${modelName}(${id})`);

    let builder = new QueryBuilder(this, modelName).byId(id);

    if (options && options.projection) {
      Ember.debug(`Flexberry Store::findRecord using projection '${options.projection}'`);

      builder.selectByProjection(options.projection);
      return this.query(modelName, builder.build()).then(result => new Ember.RSVP.Promise((resolve) => resolve(result.get('firstObject'))));
    }

    let queryObject = builder.build();

    // Now if projection is not specified then only 'id' field will be selected.
    queryObject.select = [];
    return this.query(modelName, queryObject).then(result => new Ember.RSVP.Promise((resolve) => resolve(result.get('firstObject'))));
  }
});

redpajama_set_name: RedPajamaGithub


text:
CSEM article on Innosuisse Grant
News / By viko
Swiss researchers want to develop the first-ever automated machine to bioengineer personalised skin grafts for therapy. The denovoCast project, a collaboration between life science start-up Cutiss AG and CSEM, has been awarded a grant of more than CHF 800'000 by Innosuisse.
CUTISS AG and CSEM receive Innosuisse Grant
Leave a Comment	/ Press release / By Cutiss
Zurich/Alpnach, 19 August 2019 – Swiss researchers want to develop the first-ever automated machine to bioengineer personalised skin grafts for therapy. The denovoCast project, a collaboration between life science start-up Cutiss AG and CSEM, has been awarded a grant of more than CHF 800'000 by Innosuisse.
50 million people who suffer a large skin defect every year, including burn injuries, are treated with autografting, a skin grafting method older than modern medicine, that too often leaves these patients with disfiguring and debilitating scars. Scars can impair mobility and growth and require follow-up surgeries, intense homecare and psychosocial rehabilitation.
Zurich-based Cutiss AG, a spinoff of the University of Zurich, wants to offer an alternative by bio-engineering a personalized, permanent skin graft that will minimally scar after transplantation. The company has developed denovoSkin™, which is now being tested in a multi-centric phase II clinical trial.
Produce personalized skin grafts
Using a stamp sized biopsy of the patient's own healthy skin, Cutiss is able to produce several denovoSkin™ grafts in the good manufacturing practices (GMP) facility of Wyss Zurich in a fully manual process. The next step in tissue engineering is now to move from the time-consuming manual production process to automated production in order to minimize costs, ensure robustness and scale up the process. Automation is the only way to make denovoSkin really accessible to patients in need.
To support this project, the federal innovation promotion agency, Innosuisse, has awarded a grant of CHF 826'000 for the denovoCast project, a Cutiss collaboration with the Swiss research and technology organization CSEM. Over 18 months, the project will develop an innovative approach for automating the skin engineering process while preserving the quality of the tissue.
"At Cutiss, we are proud to receive this support from the Swiss government. We have a great chance to develop and bring to market the next excellent Swiss-made innovation product," Cutiss CEO and Co-Founder Daniela Marino said. The Swiss grant comes on top of funding received from the European Union's Horizon 2020 Program.
The bioengineered skin developed by Cutiss is unique in its biological characteristics. With its strong combination of advanced skills in automatization and bioengineering, Marino sees CSEM as the ideal partner to make this critical advance in scalability for an unmet medical need.
The global burn market alone is estimated to be worth at least one CHF billion. "We want to reach out globally, ensuring personalized skin graft production as close to the patient as possible. For that, we need to have a manufacturing process which is automated, quick, robust and standardized so that it can be easily transferred allowing the de-centralization of the manufacturing. The machine developed by CSEM will bring us one step closer to this goal," Marino added.
Vincent Revol is the head of the CSEM team working on denovoCast. "The cutting-edge technology we are developing in this project has the potential to significantly increase the quality of life of millions of patients who suffer from skin defects, and, over the long term, may also be applied to other tissue engineering processes such as cornea or mucosa," he said.
A Swiss made solution
The end result envisaged by Cutiss is a skin-tissue producing machine that will be placed in multiple manufacturing facilities, starting off with Zurich. The machine, made in Switzerland, would require minimal user interaction.
"The main challenge will be to produce skin tissues on a larger scale, on a commercially relevant scale. Burn patients need a lot of new skin, as quickly as possible. We have a team working on automation and liquid handling, and another team working on the customized labware where the skin graft will be engineered." Revol said.
Cutiss AG, with a team of 19 people, has excelled on the start-up circuit, winning several awards and the backing of major investors. The company has secured 17 million CHF in funding since its founding in 2017.
Interview with Daniela Marino on CNN Money Switzerland
Media / By viko
Switzerland is perfect for Startups, but… Switzerland boasts some of the best skills in the world, according to Daniela Marino. The Cutiss CEO says Switzerland is also the "perfect place" to be an entrepreneur. So what's the catch? When it comes to money, Swiss investors aren't as willing to take risks as their American counterparts.
Interview mit Daniela Marino auf CNN Money Switzerland.
Swissmedic grants CUTISS certificates of Good Manufacturing and Distribution Practices
Swiss RTS television reportage for T.T.C.
RSI La 1, Come va? episode on skin
Journal of Wound Care: The future of bioengineering personalized skin
CUTISS's skin tissue graft is granted US patent


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INSIDE BLOOD| January 15, 2005
The more the better?
Andreas Greinacher
ERNST-MORITZ-ARNDT UNIVERSITY GREIFSWALD
Blood (2005) 105 (2): 442.
https://doi.org/10.1182/blood-2004-10-4019
Andreas Greinacher; The more the better?. Blood 2005; 105 (2): 442. doi: https://doi.org/10.1182/blood-2004-10-4019
blood platelets, platelet transfusion, autologous stem cell transplant, hemorrhage, leukemia, myelocytic, acute, transfusion, platelet count measurement
Comment on Sensebé et al, page 862
Sensebé and colleagues found that a transfused platelet dose of 1 × 1011/10 kg body weight compared with 0.5 × 1011/10 kg in patients receiving treatment for acute leukemia or autologous stem cell transplantation results in a prolongation of the time until platelet counts decline again to 20 000/μL, by 40% (from 63 hours to 95 hours) (Figure 1).
Together with the results of previous trials,1-3 this study provides further evidence that the empirically defined standard dose of a therapeutic unit of platelets may be suboptimal in some patient groups. Interestingly, at the end of the study, patients in the high-dose treatment arm received a mean of 25% more platelets than patients receiving the standard dose (18.5 × 1011 vs 14.9 × 1011). Although this did not reach statistical significance, the study seems to be underpowered for this end point. As prophylactic platelet transfusions have a major impact on hematology budgets and workload, the benefits of higher dose treatment should be balanced against any potential cost increases. In any outpatient setting of platelet transfusion–dependent patients, prolongation of transfusion intervals would have major relevance for improving quality of life. However, precaution should be given to the role of platelets as a scavenger of thrombopoietin.4 Giving more platelets may reduce patients' own thrombopoietin levels, resulting in a negative feedback on thrombopoiesis. As patients in the study of Sensebé and colleagues were followed for 336 hours only, no clear conclusion can be drawn about the long-term effect on thrombocytopenia, and results of the present study may not be generalizable to other patient populations.
The study design also followed a strategy of prophylactic platelet transfusion using a threshold of 20 000 platelets/μL; whereas, a trigger of 10 000 platelets/μL seems to be safe for platelet transfusions.5 However, it is still questionable whether an approach using any prophylactic platelet count trigger is superior to a strategy of transfusing platelets only when bleeding symptoms are present.FIG1
View largeDownload PPT
Platelet transfusion in AML and autologous stem cell transplantation. Schematic presentation of the randomized platelet transfusion trial and its major outcomes. Patients with acute myeloid leukemia or autologous stem cell transplantation received either the standard dose of 0.5 × 1011 platelets/10 kg b.w., or a higher dose of 1 × 1011 platelets/10 kg b.w. The high dose group had longer periods until the trigger of 20 000 platelets/μL was reached but received numerically more platelets.
Many resources in transfusion medicine have been used to improve the safety of blood products with impressive achievements, especially in regard to the transmission of HIV and hepatitis C. In fact, the new approaches to increase safety of blood products such as pathogen inactivation cannot be assessed in clinical trials using the most clinically important end point (reduction in pathogen transmission), because of its very low incidence. In contrast, data from the 101 patients randomized by Sensebé et al suggest that a higher dose of platelets might have an impact on bleeding complications. This raises the question how to use resources, i.e., whether a patient with acute myeloid leukemia is more threatened by viral or bacterial contamination associated with not-pathogen inactivated platelet transfusions or by major hemorrhage, which may be prevented by a higher dose of prophylactic platelet transfusions.
Finally, if dose adjustment to the patient's body weight proves to be a better platelet transfusion approach, this may have an impact on the type of platelet concentrates needed. Further studies would be required to determine whether weight-adjusted platelet dose could best be achieved using apheresis platelets or whole blood–derived platelets using the buffy coat or platelet-rich plasma technique. ▪
Norol F, Bierling P, Roudot-Thoraval F. et al. Platelet transfusion: a dose-response study.
Klumpp TR, Herman JH, Gaughan JP, et al. Clinical consequences of alterations in platelet transfusion dose: a prospective, randomized, double-blind trial.
-681.
Goodnough LT, Kluter TJ, McCullough J, et al. Prophylactic platelet transfusions from healthy apheresis platelet donors undergoing treatment with thrombopoietin.
Stefanich E, Senn T, Widmer R, Fratino C, Keller GA, Fielder PJ. Metabolism of thrombopoietin (TPO) in vivo: determination of the binding dynamics for TPO in mice.
Rebulla P, Finazzi G, Marangoni F, et al. The threshold for prophylactic platelet transfusions in adults with acute myeloid leukemia.
N Engl J Med.
Copyright © 2005 by The American Society of Hematology


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text:
Mickaël Bessaque (born 23 October 1975), is a French former footballer and football manager, most recently head coach at Montluçon.

Club career
Spending his entire career in the lower division of France, Bessaque played one full season in Ligue 2 with Rouen.

Managerial career
Having managed lower league sides Guérêt and Domerat, Bessaque was manager of Montluçon between 2018 and 2021.

References

1975 births
Living people
French footballers
French football managers
Association football midfielders
Championnat National players
Championnat National 2 players
Ligue 2 players
Stade de Reims players
Louhans-Cuiseaux FC players
Clermont Foot players
FC Rouen players
Rodez AF players
Montluçon Football players

redpajama_set_name: RedPajamaWikipedia


ProClinical is recruiting for an exciting new opening as a recruiting coordinator, based in Princeton, NJ. This role will be contracted on a six-month basis.
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The trial is limited to eight patients with newly acquired spinal-cord injuries who will receive injections of the cell therapy, called GRNOPC1, within two weeks of their accident. GRNOPC1 is made by transforming embryonic stem cells into oligodendrocytes–a type of brain cell that wraps itself around neurons, forming a fatty insulation layer that allows electrical messages to be conducted throughout the nervous system. In many spinal-cord injuries, these cells are damaged, but the underlying nerve cells remain intact. These cells are then injected into the site of the injury, coating exposed nerves and restoring communication to the nervous system.
Scientists published the results of a successful study testing the therapy in animals in 2005, showing that paralyzed rats injected with the cells were able to walk again. Since then, Geron has been conducting numerous studies intended to show the safety of the cell-based therapy, as well as developing production methods that would make the cells as easy to use as more traditional treatments. Geron researchers have also developed a way to reliably freeze and thaw brain cells, so that they can be manufactured in a central location, and then shipped to the hospitals where they will be used.
Because embryonic-stem-cell-based therapies are so new, the FDA has had trouble deciding how to evaluate new drug applications. (Geron's president and CEO, Thomas Okarma, thought approval was imminent when I spoke with him in 2006. See "Human Tests of Embryonic Stem Cell Treatments Planned.") The initial trial is designed to assess safety, but doctors will also measure its effectiveness, such as improved neuromuscular control or sensation in the trunk or lower extremities.
Geron has been undertaking studies to enable dose escalation of its spinal cord injury product, and has been investigating application of the product to other neurodegenerative diseases. The company has also been performing additional product characterization and conducting further animal studies. Data from this work has been submitted to the FDA. Geron will work closely with the FDA to facilitate their review of the new data and to release the clinical hold. No patients have yet been treated in this study.


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Our Paris office is led by a dynamic, growing team, covering a wide range of business-law specialisms.
We deliver insight and practical advice around the digital economy for French and international businesses, as well as focusing on our firm's core sectors of Retail, Transport & Automotive, Life Sciences and Health, and Energy. Main areas of expertise are mergers and acquisitions (concentrating on restructuring, venture-capital and trading transactions), tax, real estate, employment, competition and distribution, and commercial law.
Naturally, as technology-savvy lawyers, we're also strong on IP, publicity and marketing law, internet, e-commerce, information technology and data privacy.


Projecting a 2018 Opening Day roster in November is a fool's errand. There are so many variables in the MLB offseason that the armchair GMs around the country can do try as they may, but they'll never nail to a T.
Still, with free agency open and the offseason officially underway, I've taken up the task of throwing together a plan for Sandy Alderson and his lieutenants to return the Mets to contender status in 2018.
Will it go down this way? Probably not. But here's a plan that would put together a team Mets fans would be excited about on March 29. All estimated arbitration figures are courtesy of MLB Trade Rumors. All projected contracts are culled together from expert projections and adjusted based on my personal inferences.
Alderson has basically told Mets fans to expect this duo back this year, and frankly, the Mets could do worse.
I know d'Arnaud has worn on a lot of fans' patience, but there was enough about his 2017 campaign to be encouraged by, like his career highs in homers (16) and RBIs (57). A lot of that came in September (six homers, 19 RBI, .297/.343/.656), so maybe some of it was piling on against call ups, but with no discernibly better options available in free agency, I'd like to see these two push each other in a true platoon.
I know it feels like Plawecki has been around forever, but he'll be just 27 on Opening Day and is a former first round pick. He was worth 0.6 WAR in just 100 at bats last year, and was 23-for-76 with seven extra base hits after his second half recall.
More than any other area of this team, the Mets desperately need to address the infield. The defense was absolutely abysmal last year, and when you have a team built around young pitching, you're not doing it any favors fielding this nightmare. As a team, the Mets were worth -47 defensive runs saved in 2017. Jose Reyes (-25), Asdrubal Cabrera (-13), and Wilmer Flores (-12) were the worst offenders.
Having an actual shortstop on the roster will help, but the Mets should find a way to upgrade on both offense and defensive at second and third base. At this point in his career, Cabrera needs to be the "super sub" teams have begun to covet, and as much as Reyes has something left to give offensive (2.1 oWAR), his defense makes it that the Mets might be better off not bringing him back.
I know a lot of people are going to point to Frazier's batting average decline (.225 in 2016, .213 in 2017) as a reason to steer clear, but when I look closer, there is plenty to be optimistic about.
First, Frazier had a comically-low BABIP the past two seasons (.236 and .226, respectively), while the percentage of balls he hit hard was right around his career average (31.3% and 32.2%. His career average is 33%). What does that mean? That he's hitting the ball hard just as often as the years he hit .250 or higher, but he's getting less hits on those balls in play, which implies some really bad luck. What's more, Frazier's chase rate was the lowest of his career last season. He swung at just 25.1% of pitches out of the strike zone (32.3% career average), which resulted in his a career-best walk rate (14.4 walk percentage) and on-base percentage (.344).
Defensively, there is no comparison to Frazier and mish mash the Mets fielded there in 2017. In 1107.2 innings at third base, Frazier was worth 10 defensive runs saved, the best of his career (30 DRS over the course seven seasons). Add it all up and, low average and all, Frazier was worth 3.4 WAR last season. Only two Mets were worth more in 2017: Jacob deGrom (5.0) and Michael Conforto (3.6). He'd be a huge upgrade.
Gordon would be added in a trade with the rebuilding Marlins. For the sake of the argument, let's say the Mets send Steven Matz and a prospect back the other way. It would allow Miami to get a team-controlled pitcher with upside and shed Gordon's deal (he's due $51.9 million through the 2021 season, which includes a team option that can automatically vest based on plate appearances from 2019-20, or 2020 alone). In Gordon, the Mets get a true leadoff man, break away from the station-to-station style of play they've relied on for the better part of the Alderson era, and add some range to the infield.
That would leave Cabrera as your primary infield reserve. His best position at this stage in his career, by far and away, is third base (1 DRS in '17). Flores will play against lefties (primarily at first), with Smith easing his way into a full-time role. Rivera fills out the rest of the infield bench, while T.J. Rivera and Gavin Cecchini play the Matt Reynolds frequent flier role between Vegas to Flushing. The financial burden of the acquisitions is offset by recouping 75 percent of Wright's salary, should he endure another lengthy stint on the DL (which seems like a given). Also, get the captain a first baseman's glove for Spring Training, please.
Here's the most challenging part of this plan: Entering the season with the assumption that Conforto won't miss too much time. If he's ready to go on Opening Day, or even in early May, it's fine. He'll come back, assume right field, and the Mets will have mashers at the corner outfield positions. But what if May turns into Memorial Day, then June, then suddenly, the All Star break? Shoulder capsule surgery in a hitter is pretty rare, and no one knows for sure how long it will take Conforto to round back into form. So how can the Mets safeguard against a Conforto injury?
There are a few outfielders out there than can make a difference, but Jay jibes with what the Mets like to do offensively: He gets on base. Jay's .374 OBP (over 433 plate appearances) last season for the Cubs would be perfect to slot into the lineup while the Mets wait on Conforto. It leaves the Mets a little drained of power until Conforto returns, and if the Mets want a little more pop, they could opt to bring back old friend Curtis Granderson. Grandy's market will probably be softer than Jay's, and as lost as he looked in the postseason, Granderson was worth 1.7 WAR last year, is still an above average right fielder defensively, and could slide nicely into a mentor role similar to the one Carlos Beltran played for the world champion Houston Astros.
Lagares is free to roam the outfield and take extra base hits away from opposing batters, and the Mets (with the upgrades in the infield and the assumption that Conforto doesn't miss much time) should be able to live with him offensively. On the other side of the CF coin, Nimmo is serviceable defensively in center, but it's tantalizing to find out if that .379 OBP in 215 PA in 2017 can translate over a full season. The Mets could get creative here, and package Lagares to a team that has enough offense and wants a center fielder that can just go get it. But I think he has a lot more value to the Mets as they try to find ways to put less stress on the rotation by upgrading their defense.
Sure, the Mets can explore the free agent market and flirt with the likes of Jason Vargas, or explore another roll of the dice on Bartolo Colon. But even if the starting staff isn't the "Five Aces" we've been promised, based on the law of averages alone, they should be in line for a bounce back. DeGrom is a legitimate ace, as is Syndergaard. Trading Matz would mean more pressure on Wheeler to stay healthy, but it's time to get a definitive answer to that question anyway. And Lugo sets the nod here as the fifth starter over Gsellman thanks to Lugo's ability to thrive later in games. Opponents have his .329 against Gsellman the third time through the order throughout his career, and Lugo's elite spin rate on his curveball probably allows him to get away with more a little later in starts.
Trading Matz would also mean no lefty in the rotation, and that might not be preferable, especially with the reigning NL East champions boasting two pretty big bats you may have heard of: Bryce Harper and Daniel Murphy. But I'd rather spend the money on a lefty for the bullpen for high leverage spots to take some of the wear and tear off Jerry Blevins.
We know all the caveats that exist with sticking with the same group: They need to stay healthy, and make sure to avoid Cinco de Mayo ragers. But one thing is near-certain: After turning in their worst staff ERA in 2017 since their inaugural, 120-loss 1962 season, the Mets' pitchers have to be better.
Familia, Ramos, and Blevins are a fantastic starting point, but the Mets are still in the market for back end help, and they need another lefty for Callaway to turn to. Once a very good starter in Atlanta, Minor remade himself post-Tommy John with the Royals, as he hurled 77.2 innings last season en route to a 2.55 ERA and a 1.017 WHIP. A three-year deal may seem like a lot, but the way bullpen help is valued nowadays, it's a sound investment. If they whiff on Minor, I'd check in with Tony Watson, a former closer in Pittsburgh and a bit of a forgotten man in the Dodgers' pen.
Montero is the long man, and Gsellman is the swing man, who can be used in either high leverage spots or for multiple innings. I know people will shake their head at Robles' inclusion, but he was actually much better from August on (.205 opposing batting average in the second half) with a still has the stuff to succeed. If Callaway can make a big difference with someone, it could be Robles.
The Mets would take on roughly $40 million in new player salaries (Gordon, Frazier, Jay, Minor). Add up all the raises in arbitration, the new salaries, and existing contracts (while taking a $550,000 average for all pre-arbitration players), and you have an Opening Day payroll of $159.1 million, but that includes Wright's salary. If he isn't able to go and misses more than 60 games, the Mets collect 75 percent of his pay until he returns. So if insurance paid out $15 million, you're looking something in the neighborhood of $145 million.
Will the Mets land everyone on my wish list? I'd assume not. And if it's because the ask from Miami is too high for Gordon, or Frazier decides to take a one year deal and test free agency again next year, so be it. But these are not massive money moves. It's tweaking around the edges of a team that is in a rare window of team-controlled, young starting pitching at affordable prices. That doesn't last forever. By building this team, I think the Mets could very easily be contenders next year. Whether they will or not remains to be seen.


As BIA members, you are all invited to BEER and TAXES, a special event presented in partnership by the Ryerson City Building Institute, Toronto Region Board of Trade and TABIA.
On November 13, local beer from Great Lakes Brewery and light refreshments will be served at Urbanspace Gallery in 401 Richmond. See the Ryerson CBI's exhibition, TAXED OUT, on the threat of current commercial tax policy to small business and culture, enjoy a drink with members of TRBOT and TABIA, and talk property tax.


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The Chappaqua Library in New York has launched PrinterOn mobile printing. Patrons can print while at the library, or send a document for printing from home or wherever they may be then pick it up at the library.
The deployment was done through EnvisionWare, a PrinterOn partner.


text:
mazuz 248.88.(Photo by: Ariel Jerozolimski [file])
Attorney General won't charge Eitam with incitement
JPost.com Staff
NRP-NU MK had called for the expulsion of Arabs from the W. Bank, Knesset.
Attorney General Menahem Mazuz decided on Thursday that criminal charges would not be brought against MK Effi Eitam (NRP-NU) or inflammatory comments he made during the summer in which he called for the expulsion of Arabs from the West Bank and the Knesset. Eitam's comments were made in July at a memorial service for First Lieutenant Amitai Merchavia, a resident of the Eli settlement, near Ramallah in the West Bank. Merchavia had been killed days earlier in fighting with Hizbullah in southern Lebanon. "We will have to expel most of the Judea and Samaria Arabs from here. We cannot live with all these Arabs. We will have . . . to remove the Israeli Arabs from the political system," Eitam said during the service. Arab MKs immediately turned to the attorney general and demanded a criminal investigation be opened against Eitam for incitement and racism. State prosecutors weighed whether or not to bring Eitam up on charges until Thursday when Deputy State Attorney Shai Nitzan sent Eitam a letter notifying him that no criminal investigation would be opened against him. "After examination, the attorney general has come to the conclusion that your remarks seem to constitute a criminal offense," the letter reportedly said. "Nonetheless, despite the severity of the situation, the attorney general has decided that this is not the time to open a criminal investigation on the matter. This is due to the very minimized prosecution policy on such matters, especially when it comes to remarks made by MKs." The letter concluded with a warning to Eitam against further anti-Arab rhetoric that may be deemed as incitement: "The attorney general requested I inform you that future repetition of similar statements may lead to criminal procedures against you." "The prosecution system would be better off dealing with investigating and prosecuting Arab MKs who visited enemy states at a time of war and expressed support and empathy for acts of terror against Israel's citizens," Eitam said in response to the letter.
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Wade has entered the NCAA's transfer portal, Theo Lawson of the Spokesman-Review reports.
Washington State is facing some roster attrition in the wake of its offseason coaching change. Wade started just two of 29 games last season, averaging 14.4 minutes for the Cougars. He will have one year of eligibility remaining regardless of whether he transfers or returns to Washington State.
Wade is in the starting lineup for Saturday's game against Utah.
Wade (ankle) scored three points (0-1 FG, 0-1 3Pt, 3-6 FT) in 16 minutes in the win over Idaho on Wednesday.
Wade (ankle) participated in warmups and is dressed to play Wednesday against Idaho, COUGFAN.com reports.
Wade (ankle) is out Saturday against New Mexico State, play-by-play analyst Matt Chazanow reports.
Wade (ankle) isn't expected to return to the floor Tuesday against Cal State-Northridge, Dylan Haugh of 247 Sports reports.


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Home>Books>Best Books of 2019
Terri Schlichenmeyer December 30, 2019
So many books, so little time.
That's what they say, and in 2019, it was the truth. Here are the can't-miss, shouldn't-skip books of the past 12 months:
If the subject of death can be taken lightly, there's no better way than in "How Not to Die Alone" by Richard Roper. It's the story of a man who works in London as a finder: when someone dies, the people in his office are tasked with locating the survivors of the deceased. That's not the funny part; the humor comes in a blurted statement that literally takes on a life of its own, and the lengths to which the man goes to perpetuate it. Clever, witty, perfect.
Lovers of Mark Twain's adventure books will relish "This Tender Land" by William Kent Krueger, the story of two boys who run away from an Indian Training School in 1932, and they head down the Mississippi to escape the adults who want them back. Lush, exciting, and irresistible, this novel will fill a good evening or two.
What can you say about a book that starts off with an attempted suicide? That's "Talk to Me" by John Kenney, and that's what happens after a TV newscaster insults a temporary worker and because of it, his life falls completely apart. Media folks will particularly enjoy this story, but if you're a news junkie or a hardline TV watcher, you'll love it, too.
If you've already seen the movie about Harriet Tubman, then you know the kind of treat you're in for when you read "The Tubman Command" by Elizabeth Cobbs. Taking one small event from Tubman's life, this novel blows it up big and makes it exciting, while reminding readers that Tubman was a woman, first and foremost. For readers who need a novel that means something, this is it. (Tip: Get it in an audiobook for the full effect.)
And, last but not least in the fiction category, "American Pop" by Snowden Wright is a sweeping, multigenerational novel about a family who's patriarch creates a drink sensation. When he passes the business down to his scheming children, interesting — and heart-wrenching — things begin to happen …
For political animals and those who are tired of politics as usual, "Palm Beach, Mar-a-Lago, and the Rise of America's Xanadu" by Les Standiford is a book to read. It's a biography of a place and the people who made it, and it's also a history of us, our need to explore, our adventurous spirit, and our forever fascination with celebrities.
Expect something a little different in "Toil & Trouble" by Augusten Burroughs, who reveals in this book that he's a witch. Not the bubbling cauldron type, but one who knows things but can't explain why, but who still has to work to find love, home, and happiness just like the rest of us. This book is sweet and quirky and perfect.
You don't have to have visited Las Vegas, nor do you have to remember the Rat Pack to enjoy "Elvis in Vegas" by Richard Zoglin. Sure, it helps, but loving glitz, glamour, entertainers and scandal is really all you need to want this book.
It's not cheating to put together "Bitten" by Kris Newby and "Mosquito" by Timothy C. Winegard in one best-of list, because they really belong side by side on your shelf. Newby's book is about all the things that can bite you and maybe kill you. Winegard's book is about one thing that bites and kills more humans than any other creature. How can you resist books like those?
And then there's "The League of Wives" by Heath Hardage Lee, a book about the wives of the men who served in Vietnam and were captured, and what these brave women did for themselves, their husbands, and others to bring their men home. If you remember the war — or if you didn't — you owe it to yourself to read this hidden history.
It's going to be hard to decide if the story in "Sulwe" by Lupita Nyong'o is the better part of the book, or if the illustrations by Vashti Harrison are the better reason to have it. Either way, this beautiful book is about a little girl who learns to come to terms with the tone of her skin in a way that's magical. Story or illustrations? Both.
Kids ages 7-12 will love the slightly creepy story of friendship in "The Afterwards" by A.F. Harrold, illustrated by Emily Gravett. It's the story of a girl who finds a garden in which things that are dead, aren't quite dead. When she discovers her best friend in the garden, she must make a hard, hard decision. Bonus: borrow it back for a wonderful reminder of childhood friendships.
And rounding out the Best of Children's Books for 2019 is "Fraternity" by Alexandra Robbins, who takes a look at college fraternities and some young men who joined them. It's an eye-opener for teens who are heading to college soon, and it'll give parents something to think about and discuss.
And now for the housekeeping …
Some of these books are from earlier in the year, so they might be out in paperback soon. Check with your local librarian or bookseller. They're the rock stars of the book world, and they won't steer you wrong. Season's readings!
A.F. Harrold Alexandra Robbins American Pop Augusten Burroughs Bitten book reviews Elizabeth Cobbs Elvis in Vegas Fraternity Heath Hardage Lee How Not to Die Alone John Kenney Kris Newby Les Standiford Lupita Nyong'o Mosquito Palm Beach Mar-a-Lago and the Rise of America's Xanadu Richard Roper Richard Zoglin Snowden Wright Sulwe Talk to Me Terri Schlichenmeyer The Afterwards The League of Wives The Tubman Command This Tender Land Timothy C. Winegard Toil & Trouble William Kent Krueger
Terri Schlichenmeyer
Jamaica Anticipates Increased Revenue from Overflight Services
Grace Mugabe Banned from New Zealand
BOOK REVIEW: 'Mediocre: The Dangerous Legacy of White Male America' by Ijeoma Oluo
BOOK REVIEW: 'Cheeky: A Head-to-Toe Memoir' by Ariella Elovic
BOOK REVIEW: 'Everybody's Tree' by Barbara Joosse, illustrated by Renée Graef
BOOK REVIEW: A Little Christmas Romance
BOOK REVIEW: 'Dear Justyce' by Nic Stone
New & Noteworthy Books about Gastro Health


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11:00 am10 Nov 2010
We Love Arts: House of Gold
Images taken by Stan Barouh, courtesy of Woolly Mammoth
Woolly's House of Gold succeeds spectacularly at creating a unique experience in the theater that couldn't be replicated in another medium. Whether it succeeds in any other way is a difficult question.
I've spent much of the last year concerned about whether the theater experiences available to us really make use of the format. I won't rehash the same issues I wrote about in August; I'll simply say that House of Gold makes use of the space and stage design in a way that's unique, compelling, and attention-grabbing. The action takes place on multiple physical levels and, at one point, uses live video and projection. Director Sarah Benson, set designer David Zinn and everyone else involved in putting this visual together deserves a pat on the back and perhaps an award or three.
Whether the play itself works? Honestly, two days later I'm still trying to decide.
House of Gold purports to be about murdered child pageant contestant JonBenet Ramsey and our society's obsession with her. The Woolly team goes the full distance in selling this concept; the programs are fashioned as tabloid newspapers, the music playing till the second the lights go on and the action starts is a pumping mix evocative of a beauty contest. The opening scene establishes two people whose priority is performing and being heard first, everything else second. When the unnamed Man asks what's in the breakfast sausage the Woman says "JonBenet Ramsey."
"It's delicious!" Man exclaims.
It's about as subtle as a heart attack, but gets the point across pretty clearly: society craves JonBenet and doesn't care how ground up and processed she is – just give us more details about that dead white girl, and hurry up.
Unfortunately the scene is performed by the same two actors who serve as JonBenet's parents in the same costuming and setting as they'll be in later. So it's a shift to view them as other consumers rather than the directly involved people who lost a child. Is it worth it for that opening scene? I'm unsure. I know it took me out of the flow a bit.
Have no doubt: "flow" is the right word here. House of Gold is a production that intends to evoke feelings in you and create impressions. While there's a more of less linear progression in the action it's not meant to be an examination of the mystery of Ramsey's death or an accurate representation of her life. Playwright Gregory Moss says so in one of the faux articles in the tabloid program but the casting of an African-American actress to play the little blond girl should tip you off even if you don't read the interview.
Moss claims he wanted to explore why Ramsey caught the public's attention in a lasting way when so many other children haven't. I'm not sure I got that sense from the play. Ramsey as a plaything for people both in life and death, however, came through well. It succeeds best when it's being more subtle, letting the excellent Kaaron Briscoe as JonBenet interact with people who are more interested in her for how they can make them feel than as an actual person. Moss pulls out some more gasp-worthy insinuations of sexual abuse at other times and the production suffers for it.
I walked out of House of Gold strongly reminded of a musical group I'm fond of: Negativland, who are referred to as a "experimental music and sound collage band." Perhaps a less contemporary comparison would be to say it was like a news story written by James Joyce on one of his more cogent days. However you choose to think of it, walk into House of Gold prepared to absorb something in an unusual way. It may very well be the anti-Oklahoma! in this sense.
House of Gold runs at Woolly Mammoth through November 28th.
Woolly Mammoth Theater
This entry was posted in: We Love Arts


On Wednesday, August 11, 2004, an european community trademark registration was filed for LUX GLOWING TOUCH by Unilever N.V. . The OHIM has given the trademark application number of 003979549. The current status of this trademark filing is Registered. The correspondent listed for LUX GLOWING TOUCH is BAKER & MCKENZIE LLP of 100 New Bridge Street, London, GB EC4V 6JA . The LUX GLOWING TOUCH trademark is filed in the category of Cosmetics and Cleaning Products .
Goods & Services: Soaps; detergents; bleaching preparations, cleaning preparations; perfumery, toilet water, aftershave, cologne; essential oils; aromatherapy products; massage preparations; deodorants and antiperspirants; preparations for the care of the scalp and hair; shampoos and conditioners; hair colourants; hair styling products; toothpaste; mouthwash; preparations for the care of the mouth and teeth; non-medicated toilet preparations; bath and shower preparations; skin care preparations; oils, creams and lotions for the skin; shaving preparations; pre-shave and aftershave preparations; depilatory preparations; sun-tanning and sun protection preparations; cosmetics; make-up and make-up removing preparations; petroleum jelly; lip care preparations; talcum powder; cotton wool, cotton sticks; cosmetic pads, tissues or wipes; pre-moistened or impregnated cleansing pads, tissues or wipes; beauty masks, facial packs.


Don't forget to sign up for our Kids Bowl Free program that runs May-August EVERY YEAR! We now added SATURDAY to our KBF! Our KBF is for kids up to 17 years of age.
Two free games of bowling, all summer long! Subject to times and availability.
WE ADDED SATURDAY TO OUR KIDS BOWL FREE!
We can't wait to see you and meet new faces! Family Fun for the whole Family.


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Tuscaloosa, Alabama
What is Tuscaloosa, Alabama known for?
the conference voted to ban any team from having a bye in its schedule before the league championship game, returning the game to its traditional Thanksgiving weekend spot. Game results Since 1893, the Crimson Tide and Tigers have played 76 times. Alabama leads the all-time series, with 41 wins to Auburn's 34, with one tie. The game has been played in four cities: Auburn (Auburn, Alabama), Birmingham (Birmingham, Alabama), Montgomery (Montgomery, Alabama), and Tuscaloosa, Alabama
Chimes * Gorgas House * Jemison-Van de Graaff Mansion * Moundville Archaeological Park * University of Alabama Arboretum Sister cities The Tuscaloosa Sister Cities Commission was formed in 1986. The city currently has sister city relationships with cities in three countries: <
line people
found to have survived. During this period, ''The Tuscaloosa News'' posted an on-line people finder to aid loved ones and friends in finding one another and to determine who was still missing. "Help us locate loved ones". tuscaloosanews.com, 29 April 2011, Retrieved April 29, 2011 Two days after the storm, US president Barack Obama and Alabama governor Robert Bentley, and their spouses, Michelle Obama and Diane Bentley, respectively, accompanied Mayor Maddox on a tour of the damage and the recovery efforts, along with FEMA Administrator Craig Fugate and several Congressional dignitaries. Remarking about the scale and severity of the damage, Obama stated, "I've never seen devastation like this, it's heartbreaking" after touring the damaged areas. '''Pain''' was an American (United States) rock (rock music) band from Mobile (Mobile, Alabama) and Tuscaloosa (Tuscaloosa, Alabama), Alabama. The main songwriters Dan and Pose, grew up in Mobile and graduated from Mcgill Toolen High school in midtown Mobile. Though they have not produced any chart-topping hits, the band enjoyed a semi-mainstream following after touring relentlessly. Cartoon Network also aired a short two-minute music video set to their song "Jabberjaw (Running Underwater)", featuring the cartoon character of the same name along with "updated" versions of the rest of the show's characters. YouTube.com, "Jabberjaw (Running Underwater)" music video featured on Cartoon Network - Retrieved January 6, 2011 The corpse Hazel's body was taken to Adams Vermillion Furniture which also sold caskets and functioned as a funeral parlor. No one showed up to claim her, but the body wasn't decomposing, either—supposedly an effect of the poison. With an endless supply of curious visitors the proprietor started charging 10¢ a gander to see the notorious outlaw. The corpse was later loaned out to various exhibitors, including Adams' brother in Tuscaloosa (Tuscaloosa, Alabama), and Captain Harvey Lee Boswell, before it came into the possession of O. C. Brooks in 1907. He featured the well-preserved remains in his traveling show for 40 years. When he died, Brooks left Hazel to his nephew, on the condition that any money raised from displaying her be donated to charity. '''DS: That would seem like racy material for grade school or high school. :'''EW:''' I don't mean in Alabama; in America the curriculum is determined by each community, which is unlike every other country in the western world. So, in Tuscaloosa (w:Tuscaloosa, Alabama) they are not going to teach something racy, but in Darien, Connecticut (w:Darien, Connecticut) they are.
numerous water
the home of the University of Alabama, Stillman College and Shelton State Community College. While the city attracted international attention when Mercedes-Benz announced it would build its first automotive assembly plant in North America in Tuscaloosa County, the University of Alabama remains the dominant economic and cultural engine in the city. Tuscaloosa has been traditionally known as the "Druid City" because of the numerous water oaks planted in its downtown
site local
, the three stations provide at least secondary coverage from the Alabama-Georgia (Georgia (U.S. state)) state line westward to Columbus, Mississippi. WBMA WCFT WJSU operates a number of SkyCams throughout the state which send a live shot and weather information from that site. Local insurance company Alfa Insurance sponsors the network. There are SkyCams in Downtown Birmingham, Inverness (Hoover, Alabama), Gadsden (Gadsden, Alabama), Demopolis (Demopolis, Alabama), Hamilton
significant attention
University in Birmingham (Birmingham, Alabama), and George Washington University in Washington, D.C.; however he never obtained a college degree. Education and internal improvements received significant attention during Moore's first term. Construction was completed on the Alabama Insane Hospital (Bryce Hospital) at Tuscaloosa (Tuscaloosa, Alabama) and Dr. Peter Bryce was appointed its first superintendent. The Institute for the Deaf and Blind was established at Talladega
football wide
Interstate 20 (Interstate 20 (Alabama)) Interstate 59 (Interstate 59 (Alabama)) east of Tuscaloosa and US-82 (U.S. Highway 82 (Alabama)) west of Tuscaloosa - '''Johnny Lee Stallworth''' (born July 15, 1952, in Tuscaloosa, Alabama) is a former American football wide receiver who played fourteen seasons in the National Football League for the Pittsburgh Steelers. He played college football at Alabama Agricultural and Mechanical University Alabama A&M
success writing
Wilson College and after graduation in 1983, he spent four years as a reporter in North Carolina, first as a general assignment reporter for ''The Thermal Belt News Journal'' in Columbus (Columbus, North Carolina), and then as sports editor and feature writer at ''The Daily Courier'' in Forest City (Forest City, North Carolina). Later he attended the University of Alabama in Tuscaloosa (Tuscaloosa, Alabama), where he received an MFA in creative writing. He quickly found success
writing short stories, first with smaller literary magazines, then with ''Harper's (Harper's Magazine)'', which published two of his stories: "Charlotte" in 1992 and "The Prophet From Jupiter" in 1993. The latter story helped ''Harper's'' win a National Magazine Award for fiction in 1994. After high school, Black attended the University of Alabama in Tuscaloosa (Tuscaloosa, Alabama) majoring in political science. He took Army ROTC classes and finished
hits quot
on the station altogether to make way for WJOX-FM, which moved from the AM dial to become Birmingham's first FM sports talk station. On the same day, '''WUHT''' "Hot 107.7" debuted, branding itself as "Birmingham's New #1 for R & B Hits". The station now broadcasts at slightly reduced power from an antenna atop Birmingham's Red Mountain. Its musical presentation places it squarely between Cox Radio's stations, urban contemporary WBHJ (95.7 Jamz) and adult
acts performing
Northport. This nationally recognized event brings in visitors and artists from all over the United States. As several hundred talented artists bring their creations, several thousand visitors come to pay tribute to their skills. Those crowds come not only for the art, but also for the artistry of the days of old. Several artisans provide live demonstrations of blacksmithing, furniture making, quilting, and potting. There are music acts performing on stages and many varied foods available
'''Tuscaloosa''' ( Located on the Black Warrior River, it is the fifth-largest city in Alabama, with an estimated population of 95,334 in 2013. Founded in 1819, the city was named after Tuskaloosa (Chief Tuskaloosa), the chieftain of a Muskogean (Muskogean languages)-speaking people who battled and was defeated by Hernando de Soto (Hernando de Soto (explorer)) in 1540 in the Battle of Mabila (Mabila), "Tuscaloosa", ''Encyclopedia of Alabama'' and served as Alabama's capital city from 1826 to 1846.
Tuscaloosa is the regional center of industry, commerce, healthcare, and education for the area of west-central Alabama known as ''West Alabama''. It is the principal city of the Tuscaloosa Metropolitan Statistical Area, which includes Tuscaloosa, Hale (Hale County, Alabama) and Pickens (Pickens County, Alabama) counties and has an estimated metro population in 2013 of 235,628. Tuscaloosa is also the home of the University of Alabama, Stillman College and Shelton State Community College. While the city attracted international attention when Mercedes-Benz announced it would build its first automotive assembly plant in North America in Tuscaloosa County, the University of Alabama remains the dominant economic and cultural engine in the city.
Tuscaloosa has been traditionally known as the "Druid City" because of the numerous water oaks planted in its downtown streets since the 1840s. Hubbs, Guy (Spring 2009). "Tuscaloosa on My Mind", ''Alabama Historical Association newsletter''. Vol. 24, No. 1, pp. 4–5. The city has also become well known nationally for the University of Alabama's success in sports, and particularly in football. City leaders adopted the moniker "The City of Champions" after the Alabama Crimson Tide football team (Alabama Crimson Tide football) won the BCS National Championship game in 2010 (2010 BCS National Championship Game), 2012 (2012 BCS National Championship Game), and again in 2013 (2013 BCS National Championship Game). In 2008, the City of Tuscaloosa hosted the USA Olympic Triathlon (United States at the 2008 Summer Olympics) trials for the Beijing Games (2008 Summer Olympics). http: continuingstudies.ua.edu IFES ifes-tuscaloosa.html


A study to evaluate the effectiveness of condom promotion and counseling messages on uptake of condoms as a means to prevent HIV transmission in women attending postnatal and family planning clinics in Malawi and Zimbabwe.
3,000 women, regardless of HIV serostatus, attending postnatal and family planning clinics in Blantyre and Lilongwe, Malawi, and Harare, Zimbabwe.
Behavioral counseling messages for five visits over two months; subsequent quarterly visits with HIV pre-test, risk reduction, and post-test counseling.
A total of 2016 HIV-negative women from Malawi and Zimbabwe were enrolled in the condom promotion and counseling phase of the study. Of these, 1679 were tested for HIV during follow-up and 113 seroconverted, resulting in overall HIV incidence rate of 4.7 per 100 women-years (95% CI 3.8-5.6). Incidence rates were similar across sites. The major predictors of HIV acquisition were young age, presence of STIs, being unmarried, and higher educational level.


This post lists my favorite top 10 anime series. (Do not get confused with the on-going series, this list is a set of completed series).
NOTE: The ratings were based on personal opinion. I may not have watched series better than these and if I do, the list will be updated. If you feel anything is inappropriate, leave them in the comments below.


The Boxford Police Department has received a number of complaints regarding aggressive drivers around and near school busses and bus stops.
To address these concerns the Boxford Police Department's Traffic Safety Vehicle will be selecting several routes a week to follow behind a school bus both morning and afternoon, in an effort to deter this behavior.
If you see the blue semi-marked vehicle following behind a school bus please do not be concerned. The Traffic Safety Officer will follow behind school busses primarily on the main roads. If you are on a secondary roads and you have concerns please let us know.


step on the holly island of Patmos, a well preserved beauty, discover the island of Crete, largest island of Greece and birth land of one of the most prominent archaic civilizations, explore the cosmopolitan Mykonos. Visit Santorini the most spectacular of the Greek Islands.
this 8-day cruise combines everything : not only the highlights of the Turkish riviera but most of all this is the only cruise offering you the chance to marvel the most popular Greek islands including a stop to the Greek capital, mother land of the democracy and hosting city of the world famous Acropolis.


The United Arab Emirates Mubadala wealth fund is reportedly nearing a deal to invest in a Gazprom Neft subsidiary based in Western Siberia. The transaction, if closed, would mark the Abu Dhabi investment vehicle's foray into Russia's upstream sector.
Russian business daily Kommersant reported last week that Mubadala and the Russian Direct Investment Fund (RDIF) were eyeing a 49% stake in Gazpromneft-Vostok, the owner of oilfields in the Tomsk region. The pair agreed on the main terms of the purchase, valued at US$325 million, in December, the sources said. RDIF is expected to contribute US$14 million of this sum, with the remainder covered by Mubadala.
Gazpromneft-Vostok controls seven subsoil licenses in Tomsk and the neighboring Omsk region, containing both mature and undeveloped oilfields. Its proven and probable reserves stand at 296 million boe, of which over 80% is crude oil. According to the Russian energy ministry, the company produced 1.64 million tonnes (33,000 bpd) of oil in 2017, down 3% year on year.
Mubadala has made several unsuccessful attempts to enter the Russian upstream sector. In 2016, it teamed up with RDIF, Gazprom Neft, and Gazprombank to bid for the Nazymsky block in Western Siberia's Khanty-Mansiysk region, but the license was handed instead to Russia's largest oil company, Rosneft.
The following year, reports emerged that Mubadala had partnered up with Gazprom Neft once again to secure rights to the giant Erginskoye oilfield, also in Khanty-Mansiysk. However, foreign investors were barred from participating in the auction at the request of Rosneft, which later acquired the field for 20.7 billion rubles (US$367 million).
Gazprom Neft, the oil arm of Russia's state gas giant Gazprom, has sought a partner at Gazpromneft-Vostok since 2016. According to Kommersant, talks have been held with a number of investors since then, including companies from Japan and South Korea. But the highest offer came from Mubadala, sources said.


text:
Mind of an Outlaw: Selected Essays
Okla Elliott
More Online by Okla Elliott
A Book of American Martyrs
Echoes of Tattered Tongues
A Kind of Dream
Last Stories and Other Stories
The Collected Stories of Stefan Zweig
by Norman Mailer
reviewed by Okla Elliott
Whatever one's assessment of Norman Mailer's prodigious output—and the opinions on this matter are as contentious as they are varied—it can be safely said that few writers' careers match the historical span of Mailer's. His first novel, The Naked and the Dead, was published in 1948 and his last title appeared in 2007, with over thirty books and myriad shorter pieces in the intervening years. He therefore produced work in seven different decades. But what lends Mailer's career its historical sweep is not merely its longevity; his subject matter was American culture and history, and he anointed himself the chief chronicler of his nation, which he loved and criticized in equal measure.
Phillip Sipiora has usefully organized Mind of an Outlaw by decade, starting with the 1940s, which are represented by a lone essay on Mailer's choice to support the Progressive Party over the Communist Party. The following decades are more fully represented, with perhaps the 1950s and 1960s being the most interesting, since those were Mailer's most prolific years in terms of the essay form. This was also when he was helping to invent New Journalism and what we today call creative nonfiction.
From those two decades we get Mailer's two best-known essays, "The White Negro" and "Superman Comes to the Supermarket." But the collection also includes his excellent piece "Clinton and Dole: the War of the Oxymoron" about the 1996 presidential election, as well as his assessment of recent writers like Bret Easton Ellis and Jonathan Franzen—both of whom he finds admirable and lacking in various ways. As Jonathan Lethem writes in his introduction, Mailer was a writer "moving through American history as a kind of disastrous recording angel." After reading these essays in chronological order, that seems like an accurate assessment.
But what makes Mailer such a first-rate essayist? William H. Gass defines an essay by telling us what it is not.
An article is not an essay. Articles lie about the lay of their land. An article pretends to be clear about its objective and then must pretend to reach it . . . Moreover, the article does not halt at any point along the way to confess that its author is lost, or that its exposition has grown confused, or that there are attractive alternatives here and there, that its conclusions are uncertain or unimportant, that the author has lost interest; rather, the article insists on its proofs; it will hammer home even a bent nail.
The word essay comes from the French verb essayer (to try, to attempt). Mailer follows Gass's dicta about what an essay must do; he tries to enter into the mystery of his subject matter—admitting his limitations, prejudices, and predilections along the way—and he attempts to bring the reader along with him on his exploration. In Mind of an Outlaw, we see a capacious and unusual intelligence in deadly serious meditation on everything from counterculture to literature to masturbation to philosophy to race relations—and all this in a prose that never resorts to ossified thought but insists on dynamic thinking.
Mind of an Outlaw is at once a master class in the essay form, a detailed look at the cultural and political life of seven decades in American history, and a fascinating chronicle of the development of a great and controversial writer. In "First Advertisement for Myself," Mailer writes: "I am imprisoned with a perception which will settle for nothing less than making a revolution in the consciousness of our time." In "Raison d'Être," his first piece for the Village Voice, he writes: "the only way I see myself becoming one of the cherished traditions of the Village is to be actively disliked each week."
That ego, which could pendulum from grandest self-glorification to the most abject desire to be hated, is fully on display in Mind of an Outlaw, as are a dozen stations in between. The book's reception will undoubtedly be like that for most of Mailer's books: derision and praise, dismissal and flash-canonization, and, since it is nonfiction, favorable comparison with his fiction. I wish I could offer something that falls outside the usual reactions, but I have to say that while his novels are far better than some critics give them credit for, Mind of an Outlaw gives the final proof that Mailer's greatest contributions to American letters are his innovative and virtuosic forays into literary nonfiction.


The zero-day vulnerability is reminiscent of one Adobe disclosed and patched in July 2009, and comes just days after the company's head of security admitted hackers have its software in their crosshairs.
Danish bug tracker Secunia rated the threat as "extremely critical," the highest ranking in its five-step scoring system. The U.S. Computer Emergency Readiness Team (US-CERT), an arm of the federal Department of Homeland Security, also posted a warning of the vulnerability.
Attackers exploiting the flaw may be able to hijack the targeted computer, Adobe acknowledged.
Last year, hackers exploited the bug in authplay.dll using rigged PDF documents, and also used it in drive-by attacks that enticed users into viewing malicious Flash streaming media on attack sites. Adobe gave no details Friday about the attacks it had spotted -- the first of which it received Friday morning -- but it's likely that attacks will use those same tactics.
Ironically, the newest warning came just days after Brad Arkin, Adobe's director of security and privacy, said the company is in the security spotlight , but had taken several countering steps, including emphasizing development practices that have resulted in more secure code.


text:
Q: Is it possible in Spark to run concurrent jobs on the same SparkSession? I am an amateur Spark user and Scala. Although I did numerous searches, I could not find my answer.
Is it possible to assign different tasks to different executors at the same time on a single driver program?
for example, Suppose we have 10 nodes. I want to write a code to classify a dataset using Naive Bayes algorithm with five workers and at the same time, I want to assign the other five workers a task to classify the dataset with the decision tree algorithm. Afterward, I will combine the the answers.

A: HamidReza,
What you want to achieve is running two actions in parallel from your driver. It's definately possible but it only makes sense if your actions are not using the whole cluster (for a better resource management in fact).
You can use concurrency for this. There are many ways of implementing a concurrent program, starting with Futures (I can't really recommend this approach, but seems to be the most popular choice in Scala), to more advanced types like Tasks (you can take a look to popular functional libraries like Monix, Cats or Zio).

redpajama_set_name: RedPajamaStackExchange


Chicken Kitchen creates delicious healthy food from all natural, minimally processed ingredients. Our fast-casual restaurant is family, budget and waistline friendly. We pride ourselves on not using any artificial ingredients and no fryers in any of our restaurants. Chicken Kitchen is the original innovator of the chicken chop chop – juicy all-white breast meat and served with yellow rice and pita bread. Pro-tip: pair it with our signature, savory curry mustard sauce, or upgrade to a deluxe to add lettuce & tomato. We offer hearty meals for lunch and dinner. Feed your healthy addiction at our Pinecrest location on 114th & S.Dixie Hwy (US-1).