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SPINNER GmbH thanks you for visiting this website and for your interest in the products and services of the SPINNER brand. This document informs you in detail about which data SPINNER GmbH captures when you visit our website and how we protect and process this information.
Controller and data protection officer
Data capture in connection with the use of our website
Contact and quotation requests using our form or by email
Data capture when using our online shop
Transfer of data to other parties
Capture and processing of utilization data
Embedded YouTube videos
Usercentrics Consent Management Platform
Video surveillance at the SPINNER sites in Westerham, Munich and Lauenstein
Safeguarding of your personal data
1. Controller and data protection officer
Controller in the sense of Art. 4, No. 7 of the General Data Protection Regulation (GDPR) of the European Union:
SPINNER GmbH,
represented by managing directors Katharina König and Torsten Smyk
Erzgiessereistrasse 33
Phone: +49 89 12601 0
Fax: +49 89 12601 1292
TÜV SÜD Akademie GmbH
Aslihan Kilic
2. Data capture during use of our website
2.1 Data capture
Every time that our website is called, our system―i.e. the webserver―automatically captures information on the computer or other device used to access it.
The browser type and version
The operating system running on the user's device
The user's Internet service provider
The user's IP address
The date and time at which our website is accessed
The website, if any, from which the user has linked to our website
2.2 Purpose of processing
It is necessary for our system to temporarily save your IP address in order to deliver our website to your computer. For this to work, the IP address must remain stored for the duration of the session.
The information listed above is stored in log files to ensure that our website works as intended. In addition, these data allow us to improve the website and protect our IT systems (e.g. by detecting malicious attacks).
2.3 Legal basis
The legal basis for capturing and temporarily storing these data and log files is a weighing of legitimate interests as per Art. 6, Paragraph 1, (f) of the General Data Protection Regulation of the European Union (GDPR). Our legitimate interest is to make our website available..
2.4 Duration of data storage
The above-mentioned data are erased as soon as they are no longer required for the purposes for which they were captured. Data captured to enable you to access our website are deleted at the end of the current session.
3. Contact and quotation requests received via our form or email
You may contact us by using our contact form or sending a message to the provided email address. In these cases, we store the personal data that you provide together with your question or request.
3.2 Purpose of data processing
These personal data are processed by us solely for the purpose of processing your message.
3.3 Legal basis for data processing
The legal basis for processing data that you communicate to us when submitting a question or request is a weighing of legitimate interests as per Art. 6, Paragraph 1 (f) of the GDPR (our legitimate interest is to communicate with external customers and other interested parties), the performance of a precontractual condition, or the fulfillment of a contract as per Art. 6, Paragraph 1 (b) of the GDPR.
3.4 Relaying of data to third countries
The SPINNER Group operates sales branches in various regions worldwide. In the case of requests received from outside the European Union, SPINNER reserves the right to relay your data to a regionally responsible sales branch that is geographically closer to you for processing your request or subsequent orders. Requests received from within the European Union are also processed inside the EU.
To the extent that data are relayed to third countries, this is done strictly in accordance with legal requirements, e.g.:
when there is a legitimate interest in locally processing your request or
when this is required in order to fulfill the contract.
Additional details on relaying data to third countries are provided in the sections on data capture and processing below.
The above-mentioned data are erased as soon as they are no longer required for fulfilling the purpose for which they have been captured. Regarding personal data that are sent to us by email or using the contact form, this is the case when processing of your request has been completed.
You can contact us using our contact form, the provided email address, or our social media pages. In the case of social media, we store the personal data that you send together with your request.
These data are processed exclusively to facilitate the processing your request.
The legal basis for processing the data you send to use with your request is a weighing of legitimate interests as per Art. 6, Paragraph 1 (f) of the GDPR (our legitimate interest is to communicate with customers and interested parties) or the performance of a precontractual measure and/or fulfillment of a contract with you as per Art. 6, Paragraph 1 (b) of the GDPR.
Please note that you use these platforms and their functions at your own risk. The company of SPINNER does not actively relay any data from requests in social media to recipients in third countries. We wish to point out, however, that when using social media your data may be processed outside the territory of the European Union. For obtaining detailed information on how the social media providers process data, section 4.5 below contains a list including contact information and links.
The above-mentioned data are erased as soon as they are no longer required for the purpose for which they have been captured. Regarding personal data that are sent to us by email or using the contact form, this is the case when processing of your request has been completed.
For information on other processing of your data by other providers via their platforms, please consult:
Facebook: (co-)responsibility for data processing in Europe:
Facebook Ireland Ltd., 4 Grand Canal Square, Grand Canal Harbour, Dublin 2, Ireland
Data privacy policy (data guideline): https://www.facebook.com/about/privacy
Twitter: (co-)responsibility for data processing in Europe:
Data privacy policy : https://twitter.com/en/privacy
YouTube: (co-)responsibility for data processing in Europe:
Google Ireland Limited, Gordon House, Barrow Street, Dublin 4, Ireland Data privacy policy : https://policies.google.com/privacy
LinkedIn: (co-)responsibility for data processing in Europe:
LinkedIn Ireland Unlimited Company Wilton Place, Dublin 2, Ireland
Data privacy policy : https://www.linkedin.com/legal/privacy-policy
Xing: (co-)responsibility for data processing in Europe:
XING AG, Dammtorstrasse 29-32, 20354 Hamburg, Germany
Data privacy policy : https://privacy.xing.com/en
5. Data capture during use of our online shop
5.1. Data capture
If you would like to use our online shop, you must register as a user. We capture and store user and company data (name, postal address, email address, payment data etc.) that you enter. We also combine certain information, such as prices and price lists applicable to use, payment terms, Incoterms® 2020 or other conditions, with your profile. In all cases, processing of your personal data explicitly takes place on a voluntary basis, i.e. with your consent.
5.2 Data transfer for payment processing
To enable payment for orders placed in our online shop, we use the products and services of CONCARDIS GMBH at Helfmann-Park 7, 65760 Eschborn, Germany ("Concardis") and Sofort GmbH at Theresienhoehe 12, 80339 Munich, Germany ("Sofort"). If you use a credit card to pay in our online shop, Concardis receives payment data for processing your payment. If you pay by direct bank transfer in our online shop, Sofort receives payment data for processing your payment. More information is available in the data privacy policy of Concardis, which can be viewed at https://www.concardis.com/de-en/protecting-your-data, and in the data privacy policy of Sofort, which can be viewed at https://www.sofort.com/payment/wizard/getCmsContent/data_protection/EN/0/en.
For integrating the services of Concardis and Sofort in our online shop, we use the products and services of Computop Wirtschaftsinformatik GmbH, Schwarzenbergstrasse 4, 96050 Bamberg, Germany ("Computop"). We have concluded an order processing agreement with Computop for this purpose.
5.3 Purposes of data processing
We process the personal data captured by us via our online shop exclusively for the following purposes: for checking your profile (commercial customer, internal compliance, if relevant credit rating), for confirming and processing your order and payments, for delivering merchandise while meeting any applicable customs and export requirements, for providing services, for communicating with you, and possibly for analyzing the use of our online shop.
The legal basis for processing your personal data is a contract with you as per Art. 6, Paragraph 1 (b) of the GDPR and/or a weighing of legitimate interests as per Art. 6, Paragraph 1 (f) of the GDPR.
The above-mentioned data are erased as soon as they are no longer required for fulfilling the purpose for which they have been captured. Regarding data captured during registration in order to perform a contract or precontractual measures, this is the case when the data are no longer needed to perform the contract. After concluding a contract, it can also be necessary to store personal data of the other party for complying with contractual or legal obligations (e.g. the requirement to retain documents and information of relevance to taxation). We may store data relevant to invoices for up to 10 years.
6. Relaying of data
Personal data captured via this website are only transferred to third parties or contractors to the required extent. For example, we pass your address data to shipping and delivery companies in order for you to receive ordered merchandise.
6.1 Recipients and categories of recipients of personal data
The recipients of data are:
Government agencies that are legally entitled to receive data (such as social security bodies and tax authorities)
In-house departments involved in executing relevant business processes (e.g. accounting, invoicing and IT)
External contractors involved in the processing or use of personal data in accordance with Arts. 28 ff. of the GDPR
External contractors hired to perform certain business processes (e.g. shipping companies)
Companies affiliated with SPINNER (e.g. wholly owned subsidiaries)
SPINNER sales partners (e.g. distributors)
6.2 Legal basis for transferring data
Your personal data are transferred on the basis of your consent (Art. 6, Paragraph 1 (a) of the GDPR), either to fulfill a contract with you (Art. 6, Paragraph 1 (b) of the GDPR) or to comply with a legal obligation to which we are subject (Art. 6, Paragraph 1 (c) of the GDPR). Any processing of your data by a recipient at our request is based on an order processing agreement with that recipient.
We publish a newsletter to inform you about us and our offering.
In order to send you the newsletter, we need your email address. When subscribing to the newsletter, you must also give us permission to send it to you. The captured data will only be used to send the newsletter. The opening of emails and clicks made on links are captured in order to provide personalized advertising by email and via our social media channels, to display personalized content in our newsletters, on our own website, in our ProductFinder, or in our online shop, and to provide other services, communicate with you and/or possibly for analyzing the use of our website. The captured data are used only by us and by the recipients named in section 6.1 above.
The legal basis for data processing in this case is Art. 6, Paragraph 1 (a) of the GDPR (by your consent).
Our newsletter is sent via MailChimp. The plugins and functions of MailChimp are an offering of The Rocket Science Group LLC, 675 Ponce de Leon Ave NE, Suite 5000, Atlanta, GA 30308, USA.
If you subscribe to our newsletter, the data you provide are transferred to MailChimp and stored there.
MailChimp then sends you an email asking you to confirm your subscription ("double opt-in"). MailChimp uses the Google Analytics tool. You can find details on Google Analytics in section 12 of this document.
The data privacy policy of Rocket Science Group LLC can be viewed at http://mailchimp.com/legal/privacy/ .
If you subscribe to our newsletter, we also store your IP address and the date and time at which you subscribe. This is necessary in order to demonstrate that you have provided your consent, and since we are obliged under Art. 6, Paragraph 1 (c) of the GDPR to document your consent, we are also entitled to do so.
You may revoke at any time your consent for us to send you the newspaper, along with the associated capture and storage of data. You can do this using a link in the newsletters or by informing us via any of the contact channels given above.
This website uses both temporary session cookies and permanent cookies. Cookies are small text files that your Internet browser stores locally on your computer. They allow us to recognize you if and when you return to our website. This saves you, for example, the trouble of having to register again and helps us recommend relevant products to you. Cookies are a prerequisite for using the shopping basket in our online shop. If you disable cookies in your browsers, you may not be able to fully take advantage of this website's functionality.
We also use cookies to analyze use of our website and display relevant advertising to you. In this data privacy policy, we describe how to use your browser's cookie settings. The following table provides general information on the various cookies used:
Name of cookie
Duration of storage/validity
A session cookie is used to facilitate use of the many services available on this website.
Until end of session
Authentication/login
Sustains the login while you are visiting a page.
Number of products in list
Remembers the number of products to be shown in list or tile views.
Selected product list view
Remembers whether a customer has chosen the list or tile view.
MyAccount panel cookie
Remembers the navigation settings at the lower left in the customer account section.
FileDownload
Remembers PDF documents that have been downloaded.
Statistics Set and then deleted within a few seconds of verification
Google Analytics cookie used to distinguish users
Statistics 2 years
Statistics 24 hours
Used to throttle the Google Analytics request rate
Statistics 1 minute
Contains a token that can be used to retrieve a client ID from the AMP client ID service. Other possible values indicate opt-out, inflight request, or an error retrieving a client ID from the AMP client ID service.
Statistics 30 seconds to one year
gac<property-id>
Contains campaign-related information for the user. When Google Analytics and Google Ads accounts are linked, this cookie is read by Google Ads website conversion tags.
Statistics 90 days
For administering permissions to capture and process data and set cookies
Required 3 years
Newsletter window
Remembers when the newsletter window should stop displaying
Convenience Several years
AddToAny links for sharing content set a cookie for security reasons
Convenience 24 hours
Measurement of the performance of ads and campaign
Marketing 90 days
Set by Google on a test basis for checking whether your browser allows cookies to be set. Does not contain any identification attributes.
Marketing 15 minutes
Contains a randomly generated user ID that enables Google to recognize the user across domains and display personalized advertising.
Marketing 1 year
gcl_au
Contains a randomly generated user ID.
gcl_aw
This cookie is set when a user clicks an ad to go to the corresponding website. It contains information on which ad has been clicked in order to correlate any associated results, such as orders or contact requests, with the ad.
This cookie is used to synchronize the IDs of LinkedIn ads.
AnalyticsSyncHistory This cookie is used to store the time of synchronization with the cookie "lms_analytics" for users in the designated countries. Marketing 30 days
li_oatml This cookie is used to identify LinkedIn members outside of LinkedIn for advertising and analysis purposes outside the designated countries and, for a limited time only, for advertising purposes in the designated countries. Marketing 30 days
lms_ads This cookie is used to identify LinkedIn members outside of LinkedIn in the designated countries for advertising purposes. Marketing 30 days
lms_analytics This cookie is used to identify LinkedIn members in the designated countries for analysis purposes. Marketing 30 days
li_fat_id This LinkedIn cookie is an indirect member identifier used for conversion tracking, retargeting and analytics. Marketing 30 days
li_sugr This cookie is used to identify probabilistic matches of a LinkedIn user's identity outside the designated countries. Marketing 90 days
U This cookie is a browser identifier for LinkedIn users outside the designated countries. Marketing 3 months
_guid This cookie designates LinkedIn members for advertising via Google Ads. Marketing 90 days
BizographicsOptOut This cookie is used to determine opt-out status for tracking by third parties. Marketing 10 years
Consent to cookies that are not required for technical reasons can be viewed and changed at any time online on the platform's consent management platform (CMP).
9. Capture and processing of utilization data
We capture data on use of this website for statistical purposes, for improving our service, for identifying and diagnosing problems with or misuse of our online offering or telecommunications services and systems, and for marketing purposes. What we actually do with this data is described in greater detail in the following sections.
10. Embedded YouTube videos
Videos stored at YouTube are embedded in our website. The provider of the YouTube service is Google Ireland Limited ("Google"), Gordon House, Barrow Street, Dublin 4, Ireland ("YouTube"). Among other things, YouTube uses cookies to maintain the integrity of video statistics and improve the usability of cookies. Videos stored at YouTube are embedded in our website in "extended data protection mode". Cookies are only placed on your computer by YouTube if you play a video that is stored at YouTube and embedded in our website. The effect of "extended data protection mode" is that YouTube only saves cookies on your computer that contain no personally identifiable data. You can completely prevent the use of cookies by disabling them in your browser settings.
To the extent that personal data are processed by YouTube, this is done on the basis of a balancing of interests pursuant to Art. 6, Paragraph 1 (f) of the GDPR (with a legitimate interest in appropriately designing our website to meet needs) and/or on the basis of your consent in accordance with Art. 6, Paragraph 1 (a) of the GDPR.
More information on data protection and the use of cookies by YouTube is available in the data privacy policy of YouTube at https://policies.google.com/privacy?hl=en. You can also manage your cookie-related settings there.
11. Social plugins
Our website uses social plugins, i.e. plugins of social media of the provider AddToAny.
For better protection of your data when visiting our website, these plugins are not fully integrated. Instead, they are only inserted with the aid of HTML links (a so-called "Shariff solution"). This prevents a connection being made to the servers of a social media network when you open a page of our website. If you click on one of the buttons, a new window opens in your browser and calls a page of the other service provider's website, on which you can then (possibly after entering your login data) click the "like" or "share" button, for example.
To the extent that personal data are processed in connection with the use of social plugins, this is done on the basis of a balancing of interests in accordance with Art. 6, Paragraph 1 (f) of the GDPR (with our legitimate interest in designing our website to meet needs).
For information on the purpose and scope of data capture and further processing and use of captured data by other providers on their websites and your rights and possibilities for safeguarding your privacy by changing settings, please consult the data privacy policies of AddToAny (https://www.addtoany.com/privacy) and the social media providers concerned:
Facebook: https://www.facebook.com/about/privacy
Xing: https://privacy.xing.com/en
Twitter: https://twitter.com/en/privacy
LinkedIn: https://www.linkedin.com/legal/privacy-policy
YouTube: https://policies.google.com/privacy
12.1 Data capture and its purpose
This website uses Google Analytics, a web analysis service provided by Google, Inc. ("Google"). Google Analytics uses "cookies": text files that are stored on your device and permit analysis of how you use the website. The information on the use of our services generated by these cookies is typically transmitted to and stored by Google on servers in the United States. If IP anonymization is enabled on this website, Google crops the IP addresses of users in countries that belong to the European Union or have signed the EEA Agreements. Only in special cases is a full IP address first sent to a Google server in the USA and then cropped. At our request, Google uses this information to evaluate your use of this website, compile reports on website activity, and provide us with other services related to use of this website and the Internet. The IP address sent by your browser is not mingled with any other data of Google's. You can prevent cookies from being stored on your device by selecting appropriate browser settings; however, please be advised that if you do this you may not be able to fully take advantage of all of this website's functions. You can also prevent cookie-generated data pertaining to your use of this website (including your IP address) from being captured and sent to Google for processing by downloading and installing the browser plugin available at this address: http://tools.google.com/dlpage/gaoptout?hl=en. It sets an opt-out cookie that suppresses capture of your data while visiting our website.
12.2 Opting out of Google Analytics
For detailed information on the conditions of use of and protection of data by Google Analytics, please go to https://marketingplatform.google.com/about/analytics/terms/us/ or https://policies.google.com/?hl=en&gl=de. On our website, the code "gat._anonymizeIp()" has been added to Google Analytics to ensure anonymized capture of IP addresses. Please note that if you object to the associated tracking, the opt-out cookie may not have the desired effect. One solution is to install an opt-out browser add-on that is available from Google here.
12.3 Legal basis
To the extent that personal data are processed in connection with the use of Google Analytics, this is done on the basis of a balancing of interests in accordance with Art. 6, Paragraph 1 (f) of the GDPR (with our legitimate interest in designing our website to meet needs).
13. Google Ads
13.1 Method and purpose of data capture
To measure the success of ads that we place with Google ("Google Ads", formerly called "Google Adwords"), we use Google Conversion Tracking, an analysis service of Google Ireland Limited ("Google"), Gordon House, Barrow Street, Dublin 4, Ireland ("Google"). Google Ads places a "conversion cookie" on your computer if you reach our website via a Google ad. These cookies expire after 30 days and cannot be used to personally identify you. They merely register the fact that you have clicked on one of our ads and consequently been redirected to our website. This tells us the total number of users that have clicked on an ad of ours and been routed to our website. We do not receive any information that could be used to personally identify users.
The personal data that Google captures in this way are also stored and processed on servers in the United States. At this time the EU Commission has not yet passed a resolution according to which the United States generally provides an appropriate level of data protection. However, Google has committed itself to complying with the provisions of the EU-US Privacy Shield published by the U.S. Department of Trade and Industry on the processing of personal data from the member states of the EU. More information on this is available here: https://policies.google.com/privacy/frameworks?hl=en&gl=de . For more information on data protection at Google, see https://policies.google.com/privacy?gl=de&hl=en.
If you do not wish to participate in this tracking process, you can disable it at https://adssettings.google.com/authenticated. You can also disable cookies for conversion tracking by setting your browser to block cookies of the "googleadservices.com" domain.
The legal basis for processing your data is Art. 6, Paragraph 1(f) of the GDPR (a weighing of interests based on our legitimate interest in being able to measure and thus also improve the effectiveness of our online advertising).
14.Google Tag Manager
Our website uses the Google Tag Manager of Google Ireland Limited ("Google"), Gordon House, Barrow Street, Dublin 4, Ireland ("Google"). The Google Tag Manager lets us centrally insert and manage short sequences of tracking code on our website.
The Google Tag Manager is software that allows us to efficiently manage and update short sections of code called "tags" or "markers" via a user interface without any extra programming work. They are used, for example, to track your activities on our website.
Google Tag Manager does not set any cookies or store any data itself. It is merely a mediating layer that links implemented tags and corresponding scripts. Data are passed to the target systems of implemented tags without being saved.
Google receives anonymized data from us. However, these data only deal with the use of our Tag Manager and do not include any user information saved with the aid the tags. The captured information lets us optimize processes.
15. LinkedIn Insight Tag
The so-called Insight Tag of the LinkedIn social network are used on our website. It is provided by LinkedIn Ireland Unlimited Company, Wilton Place, Dublin 2, Ireland (in the following, "LinkedIn"). The LinkedIn Insight Tag is a short piece of JavaScript code that we have added to our website.
The LinkedIn Insight Tag makes it possible to capture data on visits to our website, including the URL, referring URL, IP address, device and browser attributes, a time stamp and page views. These data are encrypted, anonymized within seven days, and the anonymized data subsequently deleted within 90 days. LinkedIn does not share any data on specific users with us; instead, it provides summarized reports on the website target group as a whole and the performance of ads. LinkedIn also performs retargeting for website visitors, allowing us to use this information to display targeted advertising outside our website without identifying specific members. LinkedIn members can control the use of their personal data for advertising purposes in their account settings.
The LinkedIn Insight Tag is used for the purpose of compiling detailed campaign reports and generating information on visitors to our website to support our advertising and marketing activities. As a customer of LinkedIn's marketing solution, we deploy the LinkedIn Insight Tag to trace conversions, retargeting visitors to our website, and capture additional information on LinkedIn members who view our ads.
For more detailed information on data capture (purpose, scope, further processing and use) and your rights and possibilities for changing settings, please consult the privacy policy of LinkedIn at https://www.linkedin.com/legal/privacy-policy.
15.2 Legal basis for data processing
The legal basis for processing these personal data is Art. 6, Paragraph 1 (f) of the GDPR, and we therefore have a legitimate interest doing so for the above-mentioned purposes.
15.3 Duration of storage
These data are encrypted, anonymized within seven days, and the anonymized data subsequently deleted within 90 days.
16. Usercentrics Consent Management Platform
16.1 Data capture
We are obliged to obtain each website visitor's consent for setting cookies that are not required for technical reasons. To do this, we make use of a so-called cookie consent tool from the company of Usercentrics.
When you visit our website, a cookie banner is displayed in which you may make checkmarks to consent to cookies or cookie-based applications. No cookies requiring consent are set on your device unless you consent to them.
So that a consent or revocation of consent can be unambiguously associated with a given user, the following information is recorded and relayed to Usercentrics for storage:
An anonymized IP address
Opt-in and opt-out data
Date and time of the visit to our website
16.2 Purpose and relay to additional recipients
The purpose of this processing is to obtain the user's effective consent for cookies and cookie-based applications for which such consent is required. We use the tool of Usercentrics GmbH, Senlinger Strasse 7, 80331 Munich, Germany for this. Usercentrics is active for us as a contract processor, and we have concluded a formal agreement with Usercentrics in which it pledges to treat your data confidentially. To read the data privacy policy of Usercentrics, click on this link: https://usercentrics.com/privacy-policy/ No data of yours are provided to any other recipients or sent to any third countries or international organizations.
To the extent that cookies are set for technically required data processing for operating our website, this is done on the basis of our legitimate interest in designing our website to meet needs. Any processing of your personal data in connection with providing or revoking your consent takes place on the basis of a legal obligation as per Art. 6, Paragraph 1, Point (c) of the GDPR.
16.4Duration of storage
Consent-related data (on both consent and revocation of consent) are stored for three years.
17. Salesforce
17.1 Data capture and purpose
We use the CRM platform of the provider http://salesforce.com Germany GmbH at Erika-Mann-Strasse 31, 80636 Munich, Germany. The data processing is required to manage inquiries from interested parties who contact us and to provide customer service according to their needs. Salesforce processes data for us on the basis of an agreement concluded between us and is therefore obliged to treat your data confidentially.
For more information, see Salesforce's privacy policy: https://www.salesforce.com/company/privacy/.
To the extent that personal data are processed in connection with their use by Salesforce, this is done on the basis of a balancing of interests in accordance with Art. 6, Paragraph 1 (f) of the GDPR (with our legitimate interest in processing requests from interested parties and meeting customers' needs).
17.3 Duration of storage of personal data
The above-mentioned data are erased as soon as they are no longer required for the purpose for which they were captured. With regard to data captured during the steps preliminary to concluding a contract carrying out precontractual actions, this is the case when the data concerned are no longer needed to fulfill the contract. Also after concluding a contract, it can be necessary to store personal data of the contractual partner in order to comply with contractual or legal obligations (e.g. the requirement to retain documents and information of relevance to taxation). We may store data relevant to invoices for up to 10 years.
18. Map services
This website uses Google Maps: a map service that visually depicts geographical information. Google Maps is a service of Google Inc., 1600 Amphitheatre Parkway, Mountain View, CA 94043, USA. Google Maps collects, processes or uses personal data according to its own criteria, and SPINNER GmbH therefore accepts no responsibility for the capture, processing or use of data by Google Maps. Please refer to the terms of use of Google Maps at https://www.google.com/intl/en/help/terms_maps/ and the data privacy policy of Google Maps (Google) at https://policies.google.com/privacy?hl=en. SPINNER GmbH does not receive any data from Google Maps or data that may arise from the use of Google Maps.
To the extent that personal data are processed by SPINNER in connection with the use of Google Maps or relayed to Google, this is done on the basis of a balancing of interests in accordance with Art. 6, Paragraph 1 (f) of the GDPR (with our legitimate interest in designing our website to meet needs) and/or on the basis of your consent in accordance with Art. 6, Paragraph 1 (a) of the GDPR.
19.Video surveillance at the SPINNER sites in Westerham, Munich and Lauenstein
Some parts of our company's facilities are continuously monitored by video cameras. The monitored areas are clearly designated by unambiguous signs.
19.1 Purposes for which your personal data are processed and the legal basis for this processing
"Personal data" refers to all information relating to an identified or identifiable natural person. In order to carry out video surveillance, we process personal data of yours for the purposes named in the following on the indicated legal grounds: Exercising legitimate interests for the following purposes: to protect property, defend domiciliary rights, ensure plant security, clarifying cases of theft and incidents relevant to security, using and use recordings as evidence in judicial and extrajudicial proceedings.
The legal basis for video surveillance is Art. 6, Paragraph 1 (f) of the GDPR in conjunction with Section 4, Paragraph 1, Nos. 2 and 3 of the German Federal Data Protection Act.
The monitored areas are clearly designated by unambiguous signs. No automated decision-making with profiling takes place on the basis of your personal data.
19.2 Categories of recipients of personal data
We do not provide or grant access to your personal data to any external parties unless this is necessary to fulfill the purposes for which your personal data are processed or we have contracted other parties to perform certain tasks or provide certain services that require access to these personal data or, at leastas a minimum, if the possibility that they may require such access cannot be ruled out. Currently the external recipients of personal data are the following (at the Westerham site): Bayern Corporate Services GmbH, Arnulfstrasse 50, 80335 Munich, Germany.
In addition, your personal data are communicated to government offices or authorities to the extent that we are required to provide such information by law, by order of a government authority, or by a court decision in order to investigate criminal acts perpetrated against us. In such a case, the legal basis for processing your personal data is the prosecution of criminal acts in the sense of Section 4, Paragraph 3 of the German Federal Data Protection Act.
19.3 Relaying data to recipients in third countries or to an international organization
Your personal data will not be relayed to any recipients in third countries or any international organizations.
Your personal data will only be stored for as long as they are required for purposes for which they were captured. Depending on the site, this can be up to 120 hours. Your personal data will only be kept stored for longer than that if we are required to do so by law, by order of an authority, or by a court decision in order to investigate criminal acts. In such a case, the legal basis for processing your personal data is the prosecution of criminal acts pursuant to Section 4, Paragraph 3 of the German Federal Data Protection Act.
20. Protection of your personal data
SPINNER GmbH protects your personal data from unauthorized access, use or publication. For this purpose, SPINNER GmbH takes appropriate technical precautions based on the current state of the art in technology. If you need to enter account or credit card information in order to make payment, this is stored exclusively with the contracted PCI-DSS-certified payment service provider and not with us. However, SPINNER GmbH calls your attention to the fact that data transmission over the Internet (e.g. when communicating by email) may suffer from security issues. It is therefore not possible to guarantee that all of your personal data will be absolutely safe from unauthorized access by third parties.
Apart from this, we strongly advise you to also protect yourself, for example by keeping your passwords secret.
As a "data subject" in the sense of the GDPR, you have the following rights:
Right of access as per Art. 15 of the GDPR:You have the right to obtain from the controller confirmation as to whether or not personal data concerning you are being processed and, if this is the case, access to the personal data and other information concerning them.
Right to rectification as per Art. 16 of the GDPR:You have the right to obtain from the controller without undue delay the rectification of inaccurate personal data concerning you.
Right to erasure as per Art. 17 of the GDPR: You have the right to obtain from the controller the erasure of personal data concerning you without undue delay.
Right to restriction of processing as per Art. 18 of the GDPR: You have the right to obtain from the controller the restriction of processing of personal data concerning you.
Right to access as per Art. 20 of the GDPR: You have the right to receive from the controller the personal data concerning you that have been processed via our website in a structured, commonly used and machine-readable format.
Right to withdrawal as per Art. 7, Paragraph 3 of the GDPR: You have the right to non-retroactively withdraw, at any time and free of charge, the consent you that have given under Art. 6, Paragraph 1 (a) of the GDPR to process personal data of yours that have been obtained via our website. This will not retroactively affect the lawfulness of any processing of your personal data that has taken place with your consent prior to exercising your right of withdrawal.
Right to object as per 21 of the GDPR: If data are processed on the basis of Art. 6, Paragraph 1 (e) or (f) of the GDPR, you have the right to object at any time against the processing of your personal data for reasons arising from your particular situation.
Exercising your rights to erasure, restriction of processing, objection or withdrawal can prevent you from fully taking advantage of our website.
You can directly exercise any of your above-mentioned rights as a data subject by writing a letter to SPINNER GmbH, Erzgiessereistrasse 33, 80335 Munich, Germany or sending an email to . We will then immediately confirm in writing that you have done so and comply with your wishes. It is not sufficient to notify us by phone.
The right to lodge a complaint with a supervisory authority in accordance with Art. 77 of the GDPR: if you as an affected individual consider that the processing of personal data relating to you via our website violates the GDPR, you have the right to lodge a complaint with the responsible supervisory authority, in particular in the EU member state of your habitual residence, place of work, or place of the alleged infringement.
Responsible supervisory authority in Bavaria: Bayerisches Landesamt für Datenschutzaufsicht, Promenade 27, 91522 Ansbach, Germany, phone: +49 (0) 981 18 00 93-0, fax: +49 (0) 981 18 00 93-800, email: poststelle(at)lda.bayern(dot)de.
Please note that these rights only apply if certain other legal prerequisites are met.
This data protection information reflects the situation as of November 2021.
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The SPINNER GmbH es una empresa líder mundial en el desarrollo y fabricación de componentes de alta frecuencia de alta calidad, tales como empalmes con roscas y adaptadores, atenuadores, conectores de cables, acopladores direccionales, sistemas de combinación, filtros, divisores de frecuencia, divisores de potencia, juntas giratorias y transmisores giratorios, descargadores de sobretensión y protectores contra sobretensión, interruptores, paneles de conexiones, conductores de fibra óptica, accesorios y herramientas de AF. Además, desarrollamos soluciones individuales para sistemas de antenas distribuidas, instrumentos de medición industrial y tecnologías de fabricación y componentes de transmisión para las crecientes aplicaciones con tecnología de sensores (entre otros, el "Internet de las cosas") y las velocidades de transmisión más altas, p.ej., vídeo de 8k.
© 2022 | SPINNER GmbH | Erzgiessereistr. 33 | 80335 Múnich| Alemania | | Reservados todos los derechos.


text:
New bid to thwart shop raiders
Published: 10:32 AM June 28, 2007
A NEW initiative to prevent raids on shops is being introduced in Suffolk.Suffolk Constabulary is working in partnership with the Raid-control Trust, the East of England Co-operative Society and the Suffolk Police Authority to introduce the scheme, which aims to raise security standards in retail premises.
A NEW initiative to prevent raids on shops is being introduced in Suffolk.
Suffolk Constabulary is working in partnership with the Raid-control Trust, the East of England Co-operative Society and the Suffolk Police Authority to introduce the scheme, which aims to raise security standards in retail premises.
Originally introduced by the Metropolitan Police, Raid-control has developed into a package of security measures designed to create a safer retail environment and reduce robbery in retail premises.
It also seeks to generate evidence to convict criminals if a raid does occur.
Measures to be introduced by stores under the scheme include having image capture systems and time delay safes.
Some of the costs of introducing these measures will be met by a grant from Suffolk Police Authority. The first 45 businesses that successfully meet Raid-control standard will be eligible for a £400 rebate.
Cllr Joanna Spicer representing Suffolk Police Authority said: "These businesses are in the heart of our communities and the effects reverberate through the business into those communities, not withstanding the financial costs of police investigating the crime and the direct costs to the businesses.
"The Authority hopes that by providing some funding to businesses, it will encourage them to adopt Raid-control providing a deterrent and reassurance to staff and customers alike."
Raid-control is being launched at police headquarters in Martlesham Heath on Tuesday July 3 at 12noon.
The event is being opened by assistant chief constable Jacqui Cheer and will feature presentations from Alan Townsend from Raid Control Trust, Linda Reakes and Roy Bergernie from the East of England Co-operative Society and councillor Joanna Spicer.

redpajama_set_name: RedPajamaCommonCrawl


If you don't follow up on your posts, we'll do it for you.
When I came home from work that evening, my boyfriend was gone. All of his belongings were gone. He owned most of the furniture so the apartment was almost entirely empty. Sitting in the middle of the bare living room floor was a small box wrapped in shiny metallic pink wrapping paper, with an elaborate bow on top.
I opened the box as nervous, guilty thoughts churned in my head. Inside the box was a single roll of two-ply toilet paper. Written on the first square of tissue in red felt-tip marker was a short message: "It just wouldn't be the same."
It was all a scam. I deposited the check for $4800 and I thought I was sitting pretty. The next day I got a call saying there was a mixup with the PCH accounts and that I had to reimburse them the 4800 bucks. I figured this would happen because I didn't even sign up for the sweepstakes in the first place, so I just wrote the check for 4800 and sent it out to them to clear things up.
It turns out their check bounced, and I just sent them $4800 dollars of my own money. I was furious, but I blamed myself because I walked right into their scam.
Long story short, I spent the next three years tracking down the people responsible and beating them to death with a giant novelty bank check.
Okay, sorry about the long delay. My laptop battery is dying and I don't have much time to write this but I figured I should just post all this in case anything happens.
I finally got the replacement hard drive a few days ago, but I didn't have a day off until today so I didn't do anything with it until earlier today. It took me pretty much all day today but I used it to make an image of the mystery drive that I found sewed into that bag, just like how kd5vmo suggested. I'm normally not tech savvy at all but his instructions were pretty good and I eventually figured it out. I got everything onto the new drive and booted it up.
There was hardly anything on the drive, just four folders with random files in them. All the folders were named by a string of numbers that didn't make much sense. It wasn't a date or anything like that. The numbers were all nine digits long. I don't remember exactly what they were but they were sequential, like 009391213, 009391214, 009391215, and 009391216. That might not be exactly right but it's the best that I can remember. Most of the files were in some weird format that I couldn't open. I tried opening some of them with various programs, even text programs and they were all just a bunch of numbers and letters that didn't make any sense. Again I'm not tech savvy but after I tried to open these files for a while I called one of my friends who is in IT to come by and help me with this thing. He was just finishing dinner but he said he'd head over in a little bit.
So I was looking through the folders trying to see if there was a pattern to the file names, anything like that. I was hoping the numbers were dates but it didn't seem to fit. In each of the folders there was one excel file among all the other weird format files. These were also named with all numbers but it was shorter. I'm pretty sure this one actually was a date, something in 2004. I opened the one in the first folder (I think October 4, 2004) while I was waiting for my friend to show up and that's when things got weird.
The file opened up fine and I could see a bunch of columns. There were dates, dollar values, quantities, and some other stuff but it looked like financial stuff to me, like transaction records. The file was only open for a couple seconds and then my computer crashed. I mean completely crashed. It shut down, power off, everything. I kept trying to turn it on and it wouldn't work. I decided I'd wait for my friend to show up and hopefully he could help me out.
I went down into the kitchen and put a bunch of nachos on a plate with some shredded cheese and put it in the microwave. I was leaning against the counter waiting for my nachos and thinking about the files on the hard drive when I heard a loud static noise. For a second I thought it was something with the microwave but that wasn't it. I realized it was coming from back upstairs. I figured there must be some electrical thing going on, something to do with whatever shorted out my computer. I thought I was about to burn my house down so I ran up the steps and into my bedroom.
My speakers were blasting static and my screen was just black with white text writing over and over on the screen. I knew right away it was GPS coordinates because I do a lot of hiking and I actually just took a land navigation class last summer. So it was pretty easy to tell I was looking at lat/long, degrees, minutes, seconds. It kept refreshing but it was the same numbers over and over again. I pulled the speaker cord out so the static would stop and then I jotted down the coordinates on an old receipt. I sat there for few minutes to see if it would do anything else but it just kept repeating those same numbers. I called my buddy on his cell because to be honest I was kind of freaking out at this point and I told him what was going on. He said I should just unplug the computer so I did, and the thing went dead. He said he was about fifteen minutes away.


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This spring, everything's coming up... floral! - Susan Said... WHAT?!
If you missed the Lilly Pulitzer extravaganza (disaster?) at Target this weekend, don't despair! There's still plenty of splashy, Palm Beach inspired floral out there for all of us.
Here are a few of my personal top picks. But, you can find fabulous floral (and at every price point) at your favorite store!
Separator image Posted in WOMEN'S FASHION and tagged with Lilly Pulitzer inspired floral spring women's fashion, splashy floral for spring 2015, Susan Conforte McNeill, Susan Said...WHAT?! fashion beauty style, Susan Said...WHAT?! low entry giveaways.


text:
respiratory pigment in mollusca
The gill has a greater cohesion than that in the filibranchs. Almost all the members of the phylum (excepting Scaphopoda which lacks a distinct heart) have distinct heart which receives oxygenated blood from the respiratory organs and conveys it to the different parts of the body. In Chactoderma a pair of symmetrical lateral gills are present on each side of cloaca. The respiratory pigment is haemocyanin, which contains both iron and copper. The arrangement of the gills is remarkably uniform. Cilia generate inhalant water current drawing water below the ctenidia and exhalant current expelling water out from above them. It is more concentrated in gastropods and cephalopods. b. In A. castrensis the dissociation products of hemocyanin, characterized by gel … In Mollusca the haemoglobin is found in the plasma of Gastropods (e.g., Planorbis), and in Bivalvia (e.g., Solen, Area, etc.). Molluscs' circulatory systems are mainly open. Privacy Policy3. Molluscs (cephalopods, chitons, some gastropods) Bivalves, Arthropods (decapod crustaceans, horseshoe crabs) blood oxygen utilization coefficient. The gills are more complex, with the surface plicate or thrown into folds and grooves. The blood contains the respiratory pigment hemocyanin as an oxygen-carrier. Who has metanephridia? The aquatic respiratory structures may be placed under two heads—primary and secondary: The primary respiratory structures are ctenidia or gills. In bivalves, the branchial apparatus in addition to respiratory function acts as a food collecting organ. 4. Answered By . In Area, and Solen the pigment is haemoglobin and present in some special corpuscles in the haemolymph. A single gill, feathered on one side and united to the mantle along its whole length. In circulatory system: Blood. TF: molluscs do not have a well developed nervous system. Large pulmonary veins with extensive ramification drain oxygenated blood from lung to auricle. Assumes the shape of a feather. the pallial cavity is incompletely partitioned by a fleshy fold, the epitaenia, into a right branchial chamber and a left pulmonary chamber. It is more concentrated in gastropods and cephalopods. Such movements have been reported from Arion, a slug with a large pneumostome (Runhon & Hunter, 1970). The true ctenidium, when present, is little developed and located on the right side of the body. Narrow spaces are left between the gill filaments to permit free water flow between them but close enough so that cilia on adjacent filaments may operate together in generating water current. Adaptive or secondary gills and integument: Delicate leaflets form a rosette around the anus. Disclaimer Copyright, Zoology Notes | Exclusive Notes on Zoology for Students, Respiratory System of Rohu Fish (With Diagram) | Chordata | Zoology, Gas Exchange in Various Animals | Zoology, Essay on Earthworm: Feeding and Digestion. The most primitive ctenidia are found in zeugobranchiate prosobranchs, which are simple outgrowths of the body. Flattened gill filaments are arranged in a single row (Fig. 2. Aerial respiration takes place during aestivation and when there occurs a depletion of O2 concentration in water. This type is present in Bivalvia, but they are variously modified: ii. The ctenidia do not exist as such, being converted into a horizontal muscular septum running from the base of the foot to the mantle, and extending right back to the siphons. In many opisthobranches the dorsum bears highly vascular appendages called cerata. B. You may need to download version 2.0 now from the Chrome Web Store. Each gill separately forms a 'W' in section-.with long, narrow limbs. Examples: Pila, Triton, etc. Skeletal rods support the gill filaments. Hemocyanins, high molecular weight oxygen-binding proteins, were identified in two species of protobranch bivalve mollusks, Acila castrensis and Yoldia limatula. The following points highlight the top two types of respiration in mollusca. Before publishing your Notes on this site, please read the following pages: 1.
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One sure way to stop all the questions on "Is it a boy?' or "Is it a girl?'.
This 'Hi I'm a girl!" t-shirt lets your little lady let her presence be known before her arrival.
This is a cheeky fun t-shirt which is perfect for out and about, baby announcements and more.
Pair with jeans, shorts, linens or leggings (pretty much anything :-)) and you're set to go.


Bosch, the world's number one automotive supplier, did very well in 2018 but is more cautious about 2019. The company has also announced a push into autonomous driving systems.
The supplier said 2018 sales rose 1.5% to €77.9 billion. Its automotive division, which accounted for 47 billion in sales, performed particularly well, going up 2.3% in sales.
Earnings before interest and tax (EBIT) reached €5.3 billion, which is likely to yield an EBIT margin from operations of 6.9%.
Bosch said it is looking to expand a research alliance on self-driving vehicles by opening up to other partners, besides their current partner Daimler.
By 2025, Bosch plans to achieve €5 billion in sales in electromobility.
Over the next three years, Bosch plans to invest €4 billion to develop self-driving cars. The company is also investing in reservations, payment and parking, recharging, maintenance and infotainment.
Bosch also announced its ambitions to electrify the transportation of goods and to develop expertise in artificial intellingence.
Due to looming Brexit, threats of a trade war between the US and China and other geopolitical factors, Bosch is less optimistic about 2019 but still expects the global economy to grow by 2.3%, adding it hopes to develop better than its markets.


Previously, as a charity we commented and questioned Kenzie's actions as a Facebook sperm donor and the affects that it may have on his children. Kids Need Both Parents commented on the emotional impact on the children. Kenzie stated, meeting his son Tylan was fantastic but had no attachment, Kenzie may have no attachment however, if Kenzie's door 'will always be open to the children he has helped bring into the world', the child may form attachment with his father. Whilst stating this, Kenzie signed an agreement with each couple stating they are not able to ask him for any financial support yet 'his doors will always be open' for his children. It seems as though Kenzie is contradicting himself and may be emotionally attached.
Kenzie said he does not think a man is a necessary ingredient in a happy family. This is an uneducated statement, does Kenzie's own upbringing make it right to not grow up with a father?
If Kenzie was aware of the emotional impact a father could have on a child, he may think twice about donating his sperm on Facebook.
Most importantly, this is not fair on the child as the confusion of having two mother's and a 'special man' in Tylan's life can have a detrimental affect on him. We do not discriminate against lesbian's being mother's however, we are only considering the impact this may have on Tylan in the future.


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text:
Showing posts with label NMMA. Show all posts
Arginine and its Derivatives in Cognitive Impairment
Source: Epiphany ASD Blog
Today's post is very relevant to dementia, relevant to schizophrenia and diabetes and I believe some autism, including that of my son; agmatine is part of his Polypill therapy.
Arginine is highly versatile amino acid and you need the arginine metabolism to be working correctly, particularly in your brain.
Arginine is a widely available from diet and can be produced from citrulline and indirectly from glutamine; so you are unlikely to be deficient in arginine, except in your brain and particularly if you have Alzheimer's.
In Alzheimer's it has been shown that the microglia in effect destroy arginine in the brain and this may play a role in what initiates the disease.
Research has suggested that a deficiency in polyamines, another derivative of Arginine, is a feature of dementia.
A deficiency of arginine in the brain will likely cause a deficiency of polyamines.
Your body needs nitric oxide to maintain a healthy blood pressure and this requires arginine to follow the blue line in the above chart towards citrulline and be converted by eNOS. In most older people this does not happen and oxidative stress appears to be a big part of the problem.
Agmatine – good
Agmatine has been shown in research to have a benefit in Alzheimer's.
This could be due to increased eNOS improving blood flow, an increase in Polyamines, or by reducing insulin resistance in the brain. Recall those studies of intranasal insulin? We had "type 3 diabetes", which was a brain-specific blunting of insulin.
"Agmatine administration rescued the reduction in insulin signalling, which in turn reduced the accumulation of Aβ and p-tau in the brain. Furthermore, agmatine treatment also reduced cognitive decline. Agmatine attenuated the occurrence of AD in T2DM mice via the activation of the blunted insulin signal"
Methylarginines – not good
Two by-products of arginine are bad for you in the way Agmatine is good for you.
Nitric Oxide is produced via iNOS, nNos and eNOS. In simple terms we want nitric oxide to be produced in the endothelium, the name for cells that line the interior surface of blood vessels and lymphatic vessels, To achieve this we needs lots of the enzyme eNOS and not much iNOS or nNOS, this is one of Agmatine's jobs.
Two derivatives of arginine/proteins in the body with very long names are abbreviated to NMMA and ADMA. They both inhibit eNOS and so will restrict blood flow and this will appear as elevated blood pressure.
The methylarginines NMMA, ADMA, and SDMA are ubiquitous constituents of the main vegetables of human nutrition.
Endogenous methylarginines, N(G),N(G)-dimethyl-L-arginine (asymmetric dimethylarginine, ADMA), N(G)-N('G)-dimethyl-L-arginine (symmetric dimethylarginine; SDMA), and N(G)-monomethyl-L-arginine (monomethyl arginine; NMMA) are supposed to be produced in human body through the methylation of protein arginine residues by protein arginine methyltransferases (PRMT) and released during proteolysis of the methylated proteins. Micromolar concentration of ADMA and NMMA can compete with arginine for nitric oxide synthase (NOS) reducing nitric oxide (NO) formation, whereas SDMA does not. Indeed, increased ADMA and SDMA plasma levels or a decreased arginine/ADMA ratio is related with risk factors for chronic kidney disease and cardiovascular disease. To the best of our knowledge the exogenous presence of methylarginines, like that in fruits and vegetables, has never been described so far. Here, we report the finding that methylarginines are ubiquitous in vegetables which represent an important part of human daily diet. Some of these vegetables contain discrete amounts of ADMA, SDMA, and NMMA. Specifically, among the vegetables examined, soybean, rye, sweet pepper, broad bean, and potato contain the highest ADMA and NMMA mean levels. Our results establish that the three methylarginines, in addition to being produced endogenously, can also be taken daily through the diet in conspicuous amounts. We propose that the contribution of the methylarginines contained in the vegetables of daily diet should be taken into account when the association between vegetable assumption and their levels is evaluated in clinical studies. Furthermore, a comprehensive understanding on the role of the digestive breakdown process and intestinal absorption grade of the methylarginines contained in vegetables is now needed.
Asymmetric dimethylarginine (ADMA) is a naturally occurring chemical found in blood plasma. It is closely related to L-arginine. ADMA interferes with L-arginine in the production of nitric oxide (NO), a key chemical involved in normal endothelial function and, by extension, cardiovascular health. ADMA inhibits eNOS, which in simple terms is the good NOS, the other two being iNOS and nNOS.
ADMA is considered a marker for vascular disease.
NMMA (NG-monomethyl-l-arginine, or just called Targinine)
The following study is very interesting for your older relatives. As we already know oxidative stress is a feature of aging. Many people have high blood pressure in old age. Nitric Oxide (NO) is needed keep blood vessels wide open. In old age (>60) oxidative stress reduces NO availability to nothing.
Since oxidative stress is reversible (in this study vitamin C was used) you wonder why more older people, particularly with high blood pressure, do not take entioxidants.
Age-Related Reduction of NO Availability and Oxidative Stress in Humans
A novel finding of the present study is that in normotensive subjects, the reduction in endothelial function associated with aging seems to be mediated by a progressive reduction of NO availability, inasmuch as the inhibiting effect of L-NMMA on acetylcholine-induced vasodilation was progressively impaired by advancing age. It is worth noting that after the age of 60 years, the inhibiting effect of L-NMMA on response to acetylcholine was very weak, suggesting that in aged individuals NO availability is almost totally compromised. To assess the possible role exerted by oxidative stress, we tested the antioxidant vitamin C.19 Up to the age of 60 years, despite the evident decline in endothelium-dependent vasodilation, vitamin C did not modify the response to acetylcholine. In contrast, in the oldest individuals (age >60 years) characterized by a profound alteration in NO availability, vitamin C not only enhanced the response to the endothelial agonist but also restored the inhibiting effect of L-NMMA on vasodilation to acetylcholine. Thus, in the present study, the use of L-NMMA and vitamin C, never tested before in investigating the mechanisms responsible for the previously demonstrated age-related endothelial dysfunction in humans,17 seems to indicate that the progressive impairment in endothelium-dependent vasodilation is caused by a progressive alteration of the l-arginine-NO pathway. Only in old age (after ≈60 years) does the production of oxidative stress appear, leading to the complete compromise of NO availability.
Arginase is an enzyme that acts as the catalyst for the reaction.
arginine + H2O → ornithine + urea
People with schizophrenia and also people with diabetes tend to have high levels of Arginase. This will affect how arginine is metabolized. If arginase is increased there is less arginine that can go towards creatine, citrulline or agmatine.
Going towards citrulline involves the production of nitric oxide NO. Now in schizophrenia we see a reduction in the good type of NO, that produced in the endothelium, the cells that line the interior surface of blood vessels and lymphatic vessels. As a result, we vascular dysfunction in schizophrenia.
Agmatine is also elevated in schizophrenia, which may be one of those feedback loops since agmatine will inhibit iNOS, nNOS while increasing eNOS
So where is there a reduction in Arginine in schizophrenia?
Well it looks like it is creatine which takes the hit.
CREATINE ABNORMALITIES IN SCHIZOPHRENIA AND BIPOLAR DISORDER
"Patients with schizophrenia had a statistically significant reduction in Cr levels as compared with controls; bipolar disorder patients showed no difference in Cr as compared with controls"
In people with elevated arginase a useful strategy might be to use an arginase inhibitor.
Arginase Inhibitors: A Rational Approach Over One Century.
The next paper highlights the arginase inhibitor I favour, which is L-norvaline. The paper is from Kursk university. Kursk gave its name to the nuclear-powered submarine that was lost in the Barents Sea in 2000 and triggered a new international cooperation to rescue stricken submarines. The Battle of Kursk was the largest tank battle of all time and the final major offensive by the Germans against the Russians in World War 2, where Hitler wanted to cut off a large bulge in the front line and trap a lot of Russians. Thanks to some clever English mathematicians, encrypted German communications were readable and the Russians repositioned their forces in advance, allowing them to counter attack. The Allies then invaded Sicily and that was the end for the Germans in Russia.
Arginase Inhibitor in the Pharmacological Correction of Endothelial Dysfunction
The present research shows expressed endothelium-protective property of arginase inhibitor, L-norvaline, characterized by decrease of coefficient of endothelial dysfunction and the approached its application to a group of intact animals. In other words, L-norvaline prevents the development of systemic endothelial dysfunctions in L-NAME- and methionine-induced NO deficiency.
Age-induced memory impairment (AMI)
Now we move to Polyamines that are on the bottom left my graphic at the start of this post. Spermidine and Spermine are very beneficial derivatives of arginine that most older people will be lacking. Autophagy is the cellular garbage disposal service that is dysfunction in many neurological disorders. We generally want more autophagy.
Spermidine-triggered autophagy ameliorates memory during aging
The aging process drives the progressive deterioration of an organism and is thus subject to a complex interplay of regulatory and executing mechanisms. Our understanding of this process eventually aims at the delay and/or prevention of age-related pathologies, among them the age-dependent decrease in cognitive performance (e.g., learning and memory). Using the fruit fly Drosophila melanogaster, which combines a generally high mechanistic conservation with an efficient experimental access regarding aging and memory studies, we have recently unveiled a protective function of polyamines (including spermidine) against age-induced memory impairment (AMI). The flies' age-dependent decline of aversive olfactory memory, an established model for AMI, can be rescued by both pharmacological treatment with spermidine and genetic modulation that increases endogenous polyamine levels. Notably, we find that this effect strictly depends on autophagy, which is remarkable in light of the fact that autophagy is considered a key regulator of aging in other contexts. Given that polyamines in general and spermidine in particular are endogenous metabolites, our findings place them as candidate target substances for AMI treatment.
Spermine and spermidine reversed age-related cardiac deterioration in rats
Aging is the most important risk factor for cardiovascular disease (CVD). Slowing or reversing the physiological impact of heart aging may reduce morbidity and mortality associated with age-related CVD. The polyamines, spermine (SP) and spermidine (SPD) are essential for cell growth, differentiation and apoptosis, and levels of both decline with age. To explore the effects of these polyamines on heart aging, we administered SP or SPD intraperitoneally to 22- to 24-month-old rats for 6 weeks. Both treatments reversed and inhibited age-related myocardial morphology alterations, myocardial fibrosis, and cell apoptosis. Using combined proteomics and metabolomics analyses, we identified proteins and metabolites up- or downregulated by SP and SPD in aging rat hearts. SP upregulated 51 proteins and 28 metabolites while downregulating 80 proteins and 29 metabolites. SPD upregulated 44 proteins and 24 metabolites and downregulated 84 proteins and 176 metabolites. These molecules were mainly associated with immune responses, blood coagulation, lipid metabolism, and glutathione metabolism pathways. Our study provides novel molecular information on the cardioprotective effects of polyamines in the aging heart, and supports the notion that SP and SPD are potential clinical therapeutics targeting heart disease
Spermidine boosts autophagy to protect from synapse aging
Figure 1. summarizes the suggestion that spermidine-triggered restoration of autophagy protects synapses from age-induced changes, and thus delays the normally occurring decline of memory formation. Given that spermidine is a physiologic, easy administrable substance, future research may consider its supplementation to counter age-dependent dementia.
Spermidine operates directly at presynaptic active zone scaffolds (composed of Brp/bruchpilot protein) to allow for an autophagy-dependent homeostatic regulation of these specializations. In effect, spermidine protects learning efficacy from aging-induced decline.
Spermidine in health and disease
Having your longevity and eating too
Although caloric restriction has clear benefits for maximizing health span and life span, it is sufficiently unpleasant that few humans stick to it. Madeo et al. review evidence that increased intake of the polyamine spermidine appears to reproduce many of the healthful effects of caloric restriction, and they explain its cellular actions, which include enhancement of autophagy and protein deacetylation. Spermidine is found in foods such as wheat germ, soybeans, nuts, and some fruits and vegetables and produced by the microbiota. Increased uptake of spermidine has protective effects against cancer, metabolic disease, heart disease, and neurodegeneration.
Although spermidine induces autophagy and autophagy inhibition curtails many of the health-promoting effects of spermidine, additional mechanisms have been proposed to explain the beneficial effects of spermidine on aging. These potentially autophagy-independent mechanisms include direct antioxidant and metabolic effects on arginine bioavailability and nitric oxide (NO) production. However, it has not been formally determined whether these routes act in a completely autophagy-independent manner or are interrelated with autophagy (in an additive or synergistic way) (see the figure), and it will be important to define actionable molecular targets that explain the beneficial effects of spermidine in diverse pathophysiological settings. In this sense, it will also be of interest to explore synergisms of spermidine with other CRMs that initially act through different mechanisms.
It is a surprise that those long-lived Japanese eat Natto? Also, it is a good source of vitamin K2 and importantly it is an estrogen and so an ERβ agonist.
Not all probiotics are helpful to produce polyamines and one well known probiotic, VSL#3, has been shown to reduce their level. Choose your bacteria very carefully.
Here the probiotic strain Bifidobacterium animalis subsp. lactis LKM512 is used to increase polyamine production
Longevity in Mice IsPromoted by Probiotic-Induced Suppression of Colonic Senescence Dependent on Upregulation of Gut Bacterial Polyamine Production
Alzheimer's and Arginine
In a fairly recent study it was suggested that the immune system in the brain is being suppressed and the microglia are slightly mutated along with the over-expression of arginase. Arginase is the enzyme that coverts arginine to ornithine plus urea.
So, in Alzheimer's there will be a lack of arginine available for its other purposes.
So, we would expect a lack of creatine, agmatine and citrulline. Along the way we should see less Nitric Oxide.
Based on my graphic above, it would seem that L-Norvaline should improve the outcome in Alzheimer's mice.
We already know that Agmatine improves Alzheimer's mice, as we now should expect.
So, my cocktail for an aging mouse would be: -
· L-Norvaline (used by body builders)
· Agmatine (used by body builders)
· Creatine (used by body builders)
· Natto/wheatgerm/ LKM512 probiotic
· Vitamin C or NAC
· Citrulline (used by body builders)
· Betanin (an approved food colour additive, see below)
Served with cheese, naturally.
A New Potential Cause for Alzheimer's: Arginine DeprivatiON
Alzheimer's study suggests immune cells chew up an important amino acid
Increasingly, evidence supports the idea that the immune system, which protects our bodies from foreign invaders, plays a part in Alzheimer's disease. But the exact role of immunity in the disease is still a mystery. A new Duke University study in mice suggests that in Alzheimer's disease, certain immune cells that normally protect the brain begin to abnormally consume an important nutrient: arginine. Blocking this process with a small-molecule drug prevented the characteristic brain plaques and memory loss in a mouse model of the disease. Published April 15 in the Journal of Neuroscience, the new research not only points to a new potential cause of Alzheimer's but also may eventually lead to a new treatment strategy. "If indeed arginine consumption is so important to the disease process, maybe we could block it and reverse the disease," said senior author Carol Colton, professor of neurology at the Duke University School of Medicine, and a member of the Duke Institute for Brain Sciences. The brains of people with Alzheimer's disease show two hallmarks -- 'plaques' and 'tangles' -- that researchers have puzzled over for some time. Plaques are the build-up of sticky proteins called beta amyloid, and tangles are twisted strands of a protein called tau. In the study, the scientists used a type of mouse, called CVN-AD, that they had created several years ago by swapping out a handful of important genes to make the animal's immune system more similar to a human's. Compared with other mice used in Alzheimer's research, the CVN-AD mouse has it all: plaques and tangles, behaviour changes, and neuron loss. In addition, the gradual onset of these symptoms in the CVN-AD mouse gave researchers a chance to study its brain over time and to focus on how the disease begins, said the study's first author Matthew Kan, an MD/PhD student in Colton's lab. Looking for immune abnormalities throughout the lifespan of the mice, the group found that most immune system components stayed the same in number, but a type of brain-resident immune cells called microglia that are known first responders to infection begin to divide and change early in the disease. The microglia express a molecule, CD11c, on their surface. Isolating these cells and analyzing their patterns of gene activity, the scientists found heightened expression of genes associated with suppression of the immune system. They also found dampened expression of genes that work to ramp up the immune system. "It's surprising, because [suppression of the immune system is] not what the field has been thinking is happening in AD," Kan said. Instead, scientists have previously assumed that the brain releases molecules involved in ramping up the immune system, that supposedly damage the brain. The group did find CD11c microglia and arginase, an enzyme that breaks down arginine, are highly expressed in regions of the brain involved in memory, in the same regions where neurons had died. Blocking arginase using the small drug difluoromethylornithine (DFMO) before the start of symptoms in the mice, the scientists saw fewer CD11c microglia and plaques develop in their brains. These mice performed better on memory tests. "All of this suggests to us that if you can block this local process of amino acid deprivation, then you can protect -- the mouse, at least -- from Alzheimer's disease," Kan said. DFMO is being investigated in human clinical trials to treat some types of cancer, but it hasn't been tested as a potential therapy for Alzheimer's. In the new study, Colton's group administered it before the onset of symptoms; now they are investigating whether DFMO can treat features of Alzheimer's after they appear. Does the study suggest that people should eat more arginine or take dietary supplements? The answer is 'no,' Colton said, partly because a dense mesh of cells and blood vessels called the blood-brain barrier determines how much arginine will enter the brain. Eating more arginine may not help more get into the sites of the brain that need it. Besides, if the scientists' theory is correct, then the enzyme arginase, unless it's blocked, would still break down the arginine. "We see this study opening the doors to thinking about Alzheimer's in a completely different way, to break the stalemate of ideas in AD," Colton said. "The field has been driven by amyloid for the past 15, 20 years and we have to look at other things because we still do not understand the mechanism of disease or how to develop effective therapeutics
The full study: -
Arginine deprivation and immune suppression in a mouse model of Alzheimer's disease.
The pathogenesis of Alzheimer's disease (AD) is a critical unsolved question; and although recent studies have demonstrated a strong association between altered brain immune responses and disease progression, the mechanistic cause of neuronal dysfunction and death is unknown. We have previously described the unique CVN-AD mouse model of AD, in which immune-mediated nitric oxide is lowered to mimic human levels, resulting in a mouse model that demonstrates the cardinal features of AD, including amyloid deposition, hyperphosphorylated and aggregated tau, behavioral changes, and age-dependent hippocampal neuronal loss. Using this mouse model, we studied longitudinal changes in brain immunity in relation to neuronal loss and, contrary to the predominant view that AD pathology is driven by proinflammatory factors, we find that the pathology in CVN-AD mice is driven by local immune suppression. Areas of hippocampal neuronal death are associated with the presence of immunosuppressive CD11c(+) microglia and extracellular arginase, resulting in arginine catabolism and reduced levels of total brain arginine. Pharmacologic disruption of the arginine utilization pathway by an inhibitor of arginase and ornithine decarboxylase protected the mice from AD-like pathology and significantly decreased CD11c expression. Our findings strongly implicate local immune-mediated amino acid catabolism as a novel and potentially critical mechanism mediating the age-dependent and regional loss of neurons in humans with AD.
So Arginine for Alzheimer's? Not so simple
Eating more arginine is not an effective way to increase the level of arginine in your brain and also the high level of arginase might just soak it all up anyway.
Other science does suggest that there are other ways to increase the amount of arginine in your brain, such as L-citrulline. We have already seen that we can inhibit arginase with L-norvaline among other things.
Betanin for Alzheimer's
Since we are on Alzheimer's, we might as well include another clever idea.
Our reader Tyler highlighted another interesting Alzheimer's study, which suggests preventing/treating Alzheimer's with Betanin, the pigment in beet root.
This might sound mad, but is deadly serious. The research showed that Betanin inhibits the formation of the trademark beta-amyloid plaques that define Alzheimer's. No plaques, no Alzheimer's.
Vegetable compound could have a key role in 'beeting' Alzheimer's disease
Beetroot has already been featured in this blog; it has numerous health benefits.
To lower blood pressure and increase exercise endurance it is the nitrates that are helpful, but beetroot has numerous other effects; it even increases insulin sensitivity, so is a good choice for diabetics and pre-diabetics.
The Potential Benefits of Red Beetroot Supplementation in Health and Disease
Betanin without the beetroot?
Betanin has such a strong colour it is used commercially as a food colourant, it appears as E162 on the label. In Europe it is called Beetroot red E162 and is inexpensive.
Personally, I take my betanin with the rest of the beetroot.
Vascular Dementia - before I forget
Vascular dementia is the easiest type of cognitive impairment to understand. Reduced blood flow to the brain, most likely due to reasons including a loss of endothelial nitric oxide, effectively starves the brain. We saw how cocoa flavanols improve blood flow and hence mild cognitive impairment, this is via an NO-dependent mechanism that nobody fully understands. In autism things get more complicated and we saw in earlier posts that we seem to have unstable blood flow rather than just reduced blood flow. Nonetheless, improving cerebral blood flow may well be useful for some people with autism; so more eNOS and not too much arginase, cocoa flavanols may well be beneficial. Antioxidants are hopefully already being taken.
I was surprised just how much in the post can be implemented today with no prescription medication.
It is no surprise that certain diets (Mediterranean/Okinawan) promote not only longevity but also an extended healthy life expectancy.
I think there are some tips here for fine tuning out of balance brains found in autism, schizophrenia and bipolar.
I hope someone trials my cocktail on an Alzheimer's mouse and a regular older mouse.
· L-Norvaline and Citrulline
· Agmatine
· Creatine
· Betanin
I suspect this cocktail would be more effective than Donepezil or Memantine, neither of which address the underlying cause of Alzheimer's disease. In reality some of the above might not even be needed (e.g. creatine and citrulline).
Agmatine as an alternative for some people who respond to intranasal insulin is an interesting idea. Research seems to have stalled because the preservative in the insulin causes irritation inside the nose.
Note: Creatine deficiency is a known cause of MR/ID/Autism and some types are treatable https://creatineinfo.org/. It is detectable by Magnetic Resonance Spectroscopy or by measuring creatine levels in plasma and urine. Babies born with creatine deficiency may exhibit hypotonia (floppy baby syndrome) due to weak muscles.
Labels: ADMA, Agmatine, Alzheimer's, Arginase, Beetroot, Betanin, Creatine, Dementia, eNOS, L-Arginine, L-Norvaline, LKM512, MCI, NAC, Natto, Nitric Oxide, NMMA, Vitamin C, Wheatgerm


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Posts by Ben
Genesis BBC Recordings Five Cd Box Set out soon!!!!!
We are of course all a little sad not to have the complete recording and remixed at Wembley 75, Knebworth 78 or Birmingham 98. Also, we could have done without the Old Medley from 92.
Nevertheless, Genesis is not the only band to use the fragmentation of its archives for obvious commercial purposes. The Beatles and Led Zeppelin work in the same way among other examples.
2023 - your expectations?
I hope for the new Peter G. before the tour but it seems unlikely.
Quote from Christian
We have the same info in our news linked above.
1970-1998, some specific shows mentioned, but we doubt anything will be complete
also the composition of the artwork is awful. Genesis logos on the CDs don't seem to fit the cover and content etc
I like the artwork : it's an improvement after RKive and The Last Domino…
Tracklist on amazon.com with some mistakes (Mama, live 1980)…
PETER GABRIEL - i/o Full Moon Club subscription on Bandcamp
It's not a good news…
My expectations ?
i/o before Christmas 2023...
PETER GABRIEL - Panopticom (Bright Side Mix) - track discussion
He works on 14 new songs…
The new album will be out for Christmas 2023… 😬
PETER GABRIEL | The Making Of i/o - general info and discussion
It's a pity… isn't it ?
It's a strange communication plan…
If he decides to release a new song every full moon, the album is not ready to be released...
A nice tune but it's too much compressed for the sound. That's awful… I didn't understand his choices. I hope a different mix For the album.
Quote from agentsage
I'm Amazing (2019) is a candidate for being up-tempo.
Yes, but it was an awful track with a strange lead vocal.
I will suppose a March release, two months before the tour in order to make some promo in Europe and in USA.
SIMON COLLINS & KELLY NORDSTORM: emolecule (2023)
Simon has a very weak voice, a sort of pale copy of his father. Without the echo chamber and the reverb of his voice, there is not much left. A not unpleasant timbre but rather anodyne.
PETER GABRIEL - I/O: The Tour 2023 (general info)
I just looked at the level of ticket sales for the UK tour.
The sales are more than average: with the inflation crisis and the poverty that is setting in, the venues are filled to about 60%.
The lack of new material (even if the album is coming) and the very high price of the tickets are an obvious brake. And Peter doesn't have the same impact on the crowds as Genesis.
I think he'll still manage to fill up the venues by May.
Sales are much better on the rest of the European tour.
I'm happy with this tour but I confess that I prefer a news about the new album. No release date at all...
40th Anniversary: "Hello I Must Be Going!" by PHIL COLLINS
Probably one of his best album ! The sound is fantastic : clear and powerful.
i/o The Tour: Setlist discussion
The band is not complete : that's it.
…. Keyboard, back-up singer, another guitarist will be announced soon.
A tour before an album... Money money for Live Nation but I'm glad to see him at Lille next May!
https://www.ticketmaster.ie/ve…57eb275&mc_eid=ca1436bfea


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redpajama_set_name: RedPajamaGithub


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"I can't even see the enemy!"
The Umbarans, also known as the Shadow People, were a near-human species native to the planet of Umbara. They were characterized by their pale, bluish skin and colorless eyes. In the waning decades of the Galactic Republic, the Umbarans were represented in the pan-galactic Senate by Mee Deechi. However, they ended up joining the Confederacy of Independent Systems during the Clone Wars, bringing their extremely advanced technology to the enemies of the Republic.
The Umbarans were a slender near-human species with pale, bluish skin. They had four limbs: two legs, and two arms with five-fingered hands. They had opposable thumbs, essential for the throwing grip and the use of tools. Umbarans had gaunt, emaciated faces with gray markings around the sockets of their colorless eyes. They had a single heart, the stabbing of which was a fatal injury. Although Umbarans did have hair, some of them either were bald or shaved their heads. Because of the species' skill at manipulating others, there were rumors that Umbarans had the ability to control minds. With their colorless eyes, they were capable of seeing in the ultraviolet spectrum.
On their gloomy homeworld of Umbara, the so-called "Shadow People" formed an organized society divided into castes, and they constantly schemed to improve their social rank. Their technology was more advanced than that found in most of the galaxy. Though Umbarans were capable of speaking Galactic Basic, on their homeworld they primarily communicated in their native language, which had an alphabet that consisted of twenty-six letters. A traditional Umbaran garment was the voluminous shadow cloak.
During the Clone Wars, the Umbarans seceded from the Galactic Republic.
Umbarans evolved on Umbara, a foggy and dangerous planet located in the eponymous solar system of the Ghost Nebula. During the last decades of the Galactic Republic, they were members of that democratic government. As such, they were represented in the Galactic Senate by senator Mee Deechi. Ten years after the Invasion of Naboo, an Umbaran female named Sly Moore served as an aide to Supreme Chancellor Sheev Palpatine, leader of the Galactic Senate of the Republic. Around that time, the Sith Lord Dooku created the Confederacy of Independent Systems, an alliance of solar systems that no longer felt in tune with the Republic. During the ensuing Clone Wars, the Umbarans would stay loyal to the Republic. However, after the assassination of Mee Deechi, they chose to secede from the Republic and joined the Separatist Alliance. The advanced weaponry of their militia gave the Confederacy an edge on the battlefield as clone troopers of the Grand Army of the Republic were tasked with conquering Umbara. Despite the betrayal of Jedi General Pong Krell, the Republic got the upper hand when his Jedi colleague Obi-Wan Kenobi managed to take the capital city of Umbara. At the end of the war, Supreme Chancellor Palpatine proclaimed himself Galactic Emperor. In the height of the First Galactic Empire, Umbaran technology had been appropriated for use in the Imperial Military.


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Video: Hamas TV on when it's okay to lie
This is an April Fools Day program from Hamas' al-Aqsa television station on when it's okay to lie. It's the third of the three instances given that is the most problematic, although I have to wonder if the second instance would permit lying about marital infidelity.
Let's go to the videotape. More after the video.
I have to assume that 'lying to the enemy includes more than just saying that a suicide bomber is going to blow up in Jerusalem when he is really going to blow up in Tel Aviv. Presumably, it would also include the whole concept of taqiyya, which would allow - for example - making treaties with the Jews when one has no intention of abiding by them.
What a convenient religion....
At 1:43 AM, NormanF said...
In Islam, its permitted to lie to deceive the infidel so Muslims may gain an advantage. Now that's the hallmark of an ethical religion - one which by the way sees nothing wrong either with committing mass murder - again if is to the benefit of Islam! I think can't of any other religion that grants such convenient permission to engage in what most people think of as evil behavior. We would do well to note how all this fits in with Hamas' own anti-Semitic philosophy.
At 5:59 PM, Mother Effingby said...
Another great use for lying, is when your teenaged daughters, scared that you might kill them, need to be persuaded that you won't kill them, in order to kill them.
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Iranian sanctions, Obama style
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