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Corifollitropin α followed by menotropin for poor ovarian responders' trial (COMPORT): a protocol of a multicentre randomised trial
Nikolaos P Polyzos1,
Michel Camus1,
Joaquin Llacer2,
Konstantinos Pantos3,
Herman Tournaye1
1Centre for Reproductive Medicine, Universitair Ziekenhuis Brussel, Vrije Universiteit Brussel, Brussels, Belgium
2Instituto Bernabeu, Alicante, Spain
3Genesis Athens, Athens, Greece
Corresponding to Dr Nikolaos P Polyzos; n.polyzos{at}gmail.com, nikolaos.polyzos{at}uzbrussel.be
Background Poor response to ovarian stimulation affects a significant proportion of infertile couples undergoing in vitro fertilisation (IVF) treatment. Recently, the European Society of Human Reproduction and Embryology developed new criteria to define poor ovarian response, the so-called Bologna criteria. Although preliminary studies in these patients demonstrated very low pregnancy rates, a recent pilot study has shown promising results in women <40 years old fulfilling the criteria, after treatment with corifollitropin α followed by highly purified menotropin (hpHMG) in a gonadotropin-releasing hormone (GnRH) antagonist setting. Corifollitropin α followed by menotropin for poor ovarian responders' trial (COMPORT) is a randomised trial aiming to investigate whether this novel protocol is superior to treatment with recombinant follicle-stimulating hormone (FSH) in an antagonist setting for young poor responders.
Methods/design COMPORT is a multicentre, open label, phase III randomised trial using a parallel two-arm design. 150 patients <40 years old fulfilling the 'Bologna criteria' will be randomised to corifollitropin α followed by hpHMG (group A) or recombinant FSH (group B) in a GnRH antagonist protocol for IVF/intracytoplasmic sperm injection (ICSI). The primary outcome is the ongoing pregnancy rate (defined as the presence of intrauterine gestational sac with an embryonic pole demonstrating cardiac activity at 9–10 weeks of gestation). Secondary outcomes are clinical and biochemical pregnancy rates and number of oocytes retrieved. Central randomisation will be performed using a computer-generated list and allocation concealment will be secured with the use of sealed-opaque envelopes. A sample size of 150 women is essential to detect a difference of 19.5% in ongoing pregnancy rates between group A (28%) and group B (8.5%) with a power of 85% and a level of significance at 0.05 using a two-sided Fisher's exact test.
poor ovarian responders
Bologna criteria
corifollitropin alfa
hpHMG
This is an open-access article distributed under the terms of the Creative Commons Attribution Non-commercial License, which permits use, distribution, and reproduction in any medium, provided the original work is properly cited, the use is non commercial and is otherwise in compliance with the license. See: http://creativecommons.org/licenses/by-nc/2.0/ and http://creativecommons.org/licenses/by-nc/2.0/legalcode.
Article focus
Recently, the European Society of Human Reproduction and Embryology (ESHRE) developed new criteria to define women with poor ovarian response after ovarian stimulation for in vitro fertilisation (IVF), 'The Bologna criteria'.
Up to date no randomised trial has been published to evaluate the effectiveness of ovarian stimulation protocols in poor ovarian responders according to the new ESHRE definition.
Although poor ovarian responders according to the Bologna criteria have very low pregnancy rates after ovarian stimulation for IVF, recently a pilot study demonstrated that corifollitropin α followed by highly purified menotropin (hpHMG) may result in very promising pregnancy rates.
Corifollitropin α followed by menotropin for poor ovarian responders' trial will provide conclusive evidence regarding the superiority of a novel protocol with corifollitropin α followed by hpHMG versus recombinant follicle-stimulating hormone in a gonadotropin-releasing hormone antagonist setting for the treatment of young (<40 years old) poor ovarian responders according to the Bologna criteria.
This is the first randomised study to examine the efficacy of two stimulation protocols in poor ovarian responders as described by the newly developed ESHRE definition.
To ensure sufficient power, the study's sample size calculation was based on a previous pilot study with the use of corifollitropin α followed by hpHMG in the antagonist setting. A sample size of 150 patients has 85% power to detect significant differences.
The study is focusing only in young poor responders (<40 years). Women of advanced age (≥40 years) were not included in the study.
According to the Human Fertilisation and Embryology Authority, live-birth rate per started cycle after in vitro fertilisation (IVF) has increased fairly consistently from 14% in 1991 to 24.5% in 2010.1 Nonetheless, despite this substantial increase in live-birth rates over the years, specific patient populations experience low-pregnancy rates due to their limited ovarian response after ovarian stimulation for IVF.2 Poor ovarian responders are women who fail to respond to ovarian stimulation treatment and represent up to 20% of the population seeking fertility advice.3
Despite the numerous trials conducted in women with poor ovarian response, pregnancy rates remain low, with studies reporting a live-birth of less than 10% irrespective of the treatment protocol used and the age of the patients.4 ,5 Yet, a considerable limitation of all the randomised trials up to date is the lack of a uniform definition to describe poor ovarian responders. Up to 2011, among 47 randomised trials in women with poor ovarian response, 41 different definitions for poor ovarian response were utilized6; surprisingly, no more than three trials used the same definition, whereas even trials from the same group of investigators used different definitions among different trials.6 Thus, it appears that any effort to identify the most optimal treatment for these women seems to be futile, simply due to the lack of a uniform definition to describe women failing to respond to stimulation.
Recently, the European Society of Human Reproduction and Embryology (ESHRE) developed a new definition in order to select patients suitable for inclusion in future clinical trials as poor ovarian responders, the so-called Bologna criteria.7 However, a limited number of studies has been published to date including patients with poor ovarian response according to the 'Bologna criteria', whereas no randomised trial is published or ongoing for this population.
Preliminary reports in 'Bologna poor responders' highlight the limited prospects for these women. Natural cycle IVF has been shown to result in disappointingly low live-birth rates, regardless of patients' age8; ovarian stimulation with widely accepted treatment modalities, for example, short agonist protocol, did not appear demonstrate substantial benefits,9 while unpublished data from our centre indicate an ongoing pregnancy rate of 8.3% in women less than 40 years old and 7% in women >40 years old. Finally, novel ovarian stimulation agents such as corifollitropin α did not appear to increase pregnancy rates, underscoring their poor prognosis for achieving pregnancy.9
Nonetheless, despite the disappointing results from the vast majority of the preliminary studies in this population, a recent pilot study by our group has shown that a specific protocol may indeed be a promising option for women of younger age fulfilling the 'Bologna criteria'.10 Corifollitropin α followed by highly purified menotropin (hpHMG) in an antagonist protocol demonstrated an ongoing pregnancy rate of 28% in women <40 years, strongly suggesting the conduction of a future randomised trial testing this novel treatment protocol.10
Summary: rationale for COMPORT study
The recently developed 'Bologna criteria' by The ESHRE working group on Poor Ovarian Response Definition represent the first realistic attempt by a scientific community (ESHRE) to standardise the definition of poor ovarian response in a simple and reproducible manner, and randomised trials are needed to test the pregnancy rates in this population. In combination with the existing literature, our previous work indicates that (1) women fulfilling these criteria have very low pregnancy rates, irrespective of age (2) current treatment protocols demonstrate ongoing pregnancy rates that do not exceed 8.5% and (3) corifollitropin α followed by hpHMG might increase ongoing pregnancy rates in young patients (<40 years old) fulfilling the criteria. These findings provide a strong rationale for a definitive large randomised controlled trial. The corifollitropin α followed by menotropin for poor ovarian responders' trial (COMPORT) study will provide conclusive evidence regarding the superiority or not of this novel protocol with corifollitropin α followed by hpHMG for the treatment of young poor ovarian responders fulfilling the Bologna criteria.
The COMPORT is a multicentre, open label, phase III multicentre superiority randomised trial using a parallel group, two-arm design with 1:1 allocation ratio with a primary endpoint ongoing pregnancy rates. Four participating centres in Europe will recruit women less than 40 years who fulfil the Bologna criteria for poor ovarian response. The COMPORT study will compare controlled ovarian hyperstimulation for intracytoplasmic sperm injection (ICSI) with corifollitropin α followed by hpHMG versus recombinant follicle-stimulating hormone (rFSH), in a gonadotropin-releasing hormone antagonist setting.
Study setting
The following three centres from three different countries will be participating in the study:
Centre for Reproductive Medicine, UZ Brussel, Belgium (co-ordinating centre)
Instituto Bernabeou, Alicante Spain
Genesis Medical Center, Athens Greece
Study population and eligibility criteria
Study inclusion criteria
Patients participating in the COMPORT study will be women less than 40 years who are considered as poor ovarian responders according to the 'Bologna criteria'.7 Patients should belong to one of the categories mentioned in table 1.
Young poor ovarian responders according to the Bologna criteria
In addition, women less than 40 years will be considered eligible if they had undergone previous ovarian surgery or chemotherapy (risk factors for poor ovarian response) and have an anti-müllerian hormone (AMH) <1.1 ng/ml or an antral follicle count (AFC) <7, as suggested by the Bologna criteria.
Study exclusion criteria
Uterine abnormalities
Recent history of any current untreated endocrine abnormality
Unilateral or bilateral hydrosalpinx (visible on transvaginal ultrasound (TVUS), unless clipped)
Contraindications for the use of gonadotropins
Recent history of severe disease requiring regular treatment
Recruitment and screening
A responsible investigator will be allocated in each of the recruiting sites in order to hold responsibility of local administration of the trial. The responsible investigator of each centre will identify potentially eligible patients upon fulfilment of the 'Bologna criteria' for poor ovarian response and age <40 years. All potentially eligible patients will be screened and documented as eligible; only if they fulfil the inclusion criteria, they will be included in the study. Each of the responsible investigators in the recruiting centres will obtain informed consents for participation in the study using local IRB-approved Informed Consent forms, which will be submitted to the co-ordinating centre on the completion of the study.
Consent will be obtained at the first consultation upon fulfilment of the criteria prior to random allocation to the treatment arms.
Assignment of interventions
Randomisation and allocation of patients to study groups
Patients will be randomised to either corifollitropin α followed by hpHMG (group A) or to rFSH (group B) only after patient eligibility is established and patient consent is obtained. Actual randomisation will occur after the assessment of eligibility and signing of the informed consents using a computer-generated randomisation list. Allocation concealment will be ensured by the use of sealed opaque envelopes in the co-ordinating centre (no physician will have access in the randomisation list and envelopes will be opened by study nurses) and by central randomisation from the study nurses located in the co-ordinating centre for patients recruited from other centres (table 2).
Investigational group (group A)
On day 2 of the menstrual cycle, a single SC injection of 150 µg corifollitropin α will be administered (Stimulation Day 1). Starting on Stimulation Day 6, the patient will receive a daily SC injection of 0.25 mg ganirelix and including the day of human chorionic gonadotropin (hCG) administration to prevent premature LH surges. If at Stimulation Day 8–10 not at least one follicle ≥11 mm is visible on TVUS, then the cycle should be cancelled due to insufficient ovarian response; if one follicle ≥17 mm is observed, and tubal patency is confirmed, rescue intrauterine insemination will be performed. From Stimulation Day 8 onwards, the treatment is continued with a daily SC dose of hpHMG (300 IU/day) up to the day of hCG administration. Injections may be given by the subject herself, her partner or the medical staff (figure 1).
Schematic presentation of the treatment arms. ET, embryo transfer; OPU, ovum pick-up.
Reference group (group B)
On day 2 of the menstrual cycle, a daily SC dose of rFSH (300 IU/day) is administered up to the day of hCG administration (Stimulation Day 1). Starting on Stimulation Day 6, the subject will receive a daily SC injection of 0.25 mg ganirelix up to and including the day of hCG administration to prevent premature LH surges. If at Stimulation Days 8–10 not at least one follicle ≥11 mm is visible on TVUS, the cycle should be cancelled due to insufficient ovarian response; if one follicle ≥17 mm is observed and tubal patency is confirmed, rescue intrauterine insemination will be performed. Injections may be given by the subject herself, her partner or the medical staff (figure 1).
Both groups
As soon as two follicles ≥17 mm are observed by TVUS, chorionic gonadotropin (uhCG, 10 000 or rechCG 250 μg) has to be administered the same day or the day thereafter to induce final oocyte maturation. About 34–36 h thereafter, oocyte pick-up followed by ICSI will be performed. At day 3 after oocyte pick-up, a maximum of three embryos will be replaced. Luteal phase support with progesterone tablets (200 mg ×3, intravaginally) will be initiated on the day of oocyte pick-up or the day thereafter and continued for at least 6 weeks or either up to menses or up to negative pregnancy test performed at least 14 days after oocyte pick up (figure 1).
Primary efficacy endpoint
The primary efficacy endpoint is the ongoing pregnancy rates, defined as the presence of intrauterine gestational sac with an embryonic pole demonstrating cardiac activity at 9–10 weeks of gestation.
Key secondary efficacy endpoints
The key secondary endpoints are
Clinical pregnancy rates (defined as the presence of intrauterine gestational sac at 7 weeks of gestation);
Biochemical pregnancy (defined as positive pregnancy test 2 weeks after embryo transfer);
Number of oocytes retrieved.
Other efficacy endpoints
Cycle cancellation due to poor-ovarian response;
Number of cycles reaching the stage of embryo transfer;
Number and quality of embryos;
Number of cycles with frozen supernumerary embryos;
Endocrine parameters (LH,FSH, E2, Progesterone) during ovarian stimulation.
Prespecified safety endpoints
The prespecified safety endpoint is the percentage of patients with cycle cancellation due to serious adverse effects s(AE). Serious adverse effects of medication are defined in accordance to FDA guidelines. http://www.fda.gov/safety/medwatch/howtoreport/ucm053087.htm
Assessment of adverse events will be performed 20–25 days after the initiation of ovarian stimulation. All patients will be monitored for the occurrence of any adverse effect and cycle cancellation (during ovarian stimulation) due to a serious adverse effect from medication.
Participants follow-up
Patients will be followed in a uniform manner across recruiting centres with specific interventions at specific time points. Table 2 summarises the procedures during a trial's conduction with detailed description and exact time of assessment.
Trial conduct procedures with detailed description and time of assessment
Participants may withdraw from the study at any time. Patients' follow-up will continue within the participating unit, and no data will be used after the decision of the patient to withdraw from the study. Withdrawals and reasons for withdrawal will be kept and reported.
Criteria for discontinuing or modifying allocated interventions
Participants may discontinue trial at their request or upon the occurrence of a serious adverse event. In case of monofollicular development, per protocol, participants will proceed in rescue insemination if tubal patency is confirmed. However, patients may proceed with stimulation upon their request. In such cases, the cycle will be considered as cancelled. In case of gonadotropins dose modification during treatment, the patient will be excluded from the study as a protocol violation.
Duration of the study
The study duration is estimated to be of 1 year duration with final date of completion of patients' recruitment on February–March 2014.
Analysis will be performed in an intent-to-treat fashion. All patients will be included in the final analysis as long as upon fulfilment of inclusion criteria they were randomly allocated to one of the treatment groups.
Sample size calculation
Sample size calculation was performed after considering results from a pilot study with corifollitropin α followed by hpHMG and results from a large series of young poor responders in our centre.
Based on the fact that our pilot study demonstrated an ongoing pregnancy rate per patient of 28% in young poor responders treated with corifollitropin α followed by hpHMG, whereas standard stimulation (including rFSH in an antagonist setting) in our centre has shown an ongoing pregnancy rate of 8.5%, we hypothesised that a randomised trial is essential to detect a difference of 19.5% (from 8.5% to 28%) between treatment with rFSH in an antagonist setting versus corifollitropin α followed by HMG in an antagonist setting.
Consequently, we calculated that group sample sizes of 75 and 75 patients achieve 85% power to detect a difference of 19.5% in ongoing pregnancy rates between the null hypothesis that in both groups the pregnancy rates are 8.5% and the alternative hypothesis that the pregnancy rates in the corifollitropin αhp-HMG group is 28% using a two-sided Fisher's exact test with a significance level (α) of 0.05.
Statistical methods for analysis primary and secondary outcomes
Descriptive summary measures expressed as mean (SD) or median (IQR) will be used for continuous variables and number (per cent) for categorical variables, in order to provide a summary estimate of patient demographics and baseline characteristics. The analysis and reporting of the results of the clinical outcomes will follow the CONSORT guidelines (http://www.consort-statement.org).
For the primary outcome (ongoing pregnancy rates) and for the other secondary pregnancy outcomes (clinical pregnancy and biochemical pregnancy) results will be analysed by using a two-sided χ² test with a level of significance p<0.05. Results will be summarised with a relative risk and 95% CI.
The mean number of oocytes retrieved will be compared between treatment groups by using parametric (independent t test) or non-parametric (Mann-Whitney test) tests depending on the normality of the distribution of the results with a level of significance p<0.05.
Other secondary outcomes will be analysed with the use of χ² or Fisher exact test if categorical (cycle cancellation due to poor ovarian response, cycles with embryo transfer, number of cycles with frozen supernumerary embryos) or with the use of independent t test or Mann-Whitney test (number and quality of embryos and endocrine parameters (LH, FSH, E2, Progesterone)) during ovarian stimulation. All tests will be two-sided with a level of significance p<0.05. All analyses will be performed in SPSS V.20 Statistical software.
Accounting for missing data
Efficacy analyses will be carried out per randomised patient. If a subject does not reach a certain stage in IVF treatment, zero values will be imputed (eg, pregnancy outcomes will be set to not pregnant).
Additional analyses will be performed for different stages (eg, pregnancy rates will be calculated only for those subjects who had oocyte retrieval or those who reached embryo transfer). As a consequence, patients who discontinue will be part of this analysis until they discontinue.
Missing numbers for subjects who reached a certain stage are not (frequently) expected. Participants who are lost to follow-up before a TVUS assessment will be counted as non-pregnant. For other parameters like oocytes, embryos etc, if missing values occur, then they will not be imputed.
The same extraction form for baseline characteristics, efficacy and safety endpoints will be distributed to each of the participating centres. The leading investigator in each of the recruiting centres will be responsible for the collection of individual patient data, for their accuracy and validity. The principal investigator of the study will have responsibility for the collection of data from each of the participating centres by the end of the study.
Data monitoring
Owing to the short duration of the study and the known minimal risks (extremely low chance of ovarian hyperstimulation in this group of patients and use of all medical products in accordance with the summary products characteristics), no need for data monitoring committee has been considered essential. There will be only one analysis by the end of the study. However, the principal investigator will be in contact with the leading investigators of each centre in order to review safety data and monitor the progress of the trial.
Feasibility of the study
Poor ovarian responders are women who had numerous unsuccessful IVF/ICSI trials, with an established poor prognosis, who are willing to participate in clinical trials. In our centre, approximately 20 poor ovarian responders are seen in outpatient clinic on weekly basis. Among them, around 40–50% (8–10 patients) are poor ovarian responders <40 years and are women suitable for inclusion in the study. The estimated participation rate is >80% (based on participation in ongoing pilot studies in this population in our centre). However, to secure recruitment and completion of the study within a timeframe of 6–12 months, two additional centres will enrol patients in the study (all of the recruiting centres have an annual number of fresh IVF/ICSI cycles between 1000 and –2500 cycles) suggesting that recruitment is likely to be high. In order to ensure adequate participant enrolment, recruiting doctors from participating centres will prescreen all patients' files before their first consultation in order to confirm eligibility.
The authors would like to thank the study nurses and administrative staff of the co-ordinating centre in UZBrussel: Elsie Nulens, Ellen Van Moer, Patricia Ackermans, Nicky Dooms and Saskia Van Ginderdeuren for their invaluable help for the set up of the current randomised trial. The authors would also like to thank Walter Meul for his invaluable help in the preparations of the electronic files.
HFEA. HFEA Fertility Trends and Figures 2011-Annual Register Report, 2011. http://www.hfea.gov.uk/docs/HFEA_Fertility_Trends_and_Figures_2011_-_Annual_Register_Report.pdf
Oudendijk JF,
Yarde F,
Eijkemans MJ,
. The poor responder in IVF: is the prognosis always poor? A systematic review. Hum Reprod Update 2012;18:1–11.
Ubaldi FM,
Rienzi L,
Ferrero S,
. Management of poor responders in IVF. Reprod Biomed Online 2005;10:235–46.
El-Toukhy T,
Khalaf Y,
Hart R,
. Young age does not protect against the adverse effects of reduced ovarian reserve—an eight year study. Hum Reprod 2002;17:1519–24.
Sunkara SK,
Tuthill J,
Khairy M,
. Pituitary suppression regimens in poor responders undergoing IVF treatment: a systematic review and meta-analysis. Reprod Biomed Online 2007;15:539–46.
Polyzos NP,
Devroey P
. A systematic review of randomized trials for the treatment of poor ovarian responders: is there any light at the end of the tunnel? Fertil Steril 2011;96:1058–61 e7.
Ferraretti AP,
La Marca A,
Fauser BC,
. ESHRE consensus on the definition of 'poor response' to ovarian stimulation for in vitro fertilization: the Bologna criteria. Hum Reprod 2011;26:1616–24.
Blockeel C,
Verpoest W,
. Live birth rates following natural cycle IVF in women with poor ovarian response according to the Bologna criteria. Hum Reprod 2012;27:3481–6.
Devos M,
Humaidan P,
. Corifollitropin alfa followed by rFSH in a GnRH antagonist protocol for poor ovarian responder patients: an observational pilot study. Fertil Steril 2013;99:422–6.
De Vos M,
Corona R,
. Addition of highly purified HMG after corifollitropin alfa in antagonist-treated poor ovarian responders: a pilot study. Hum Reprod 2013;28:1254–60.
Contributors NPP is the principal investigator, developed the concept, designed the study and wrote the protocol. MC, JL, KP, and HT were substantially involved in the design of the study and critically revised the manuscript. All the authors gave their final approval of the version to be published.
Funding This research received no specific grant from any funding agency in the public, commercial or not-for-profit sectors.
Competing interests NPP has received honoraria for lectures from MSD.
Ethics approval The COMPORT protocol has been approved by the UZ Brussel Ethics Committee reference number: BUN 143201316398. Strict confidentiality of all personal and research data will be ensured. Principal investigators in all recruiting centres signed a clinical trial agreement document detailing their commitment towards complying with the relevant laws, regulations, codes of practice and obligations to publication. Site-specific institutional review board approval is required for each recruiting unit. COMPORT is registered in the European Union Drug Regulating Authorities Clinical Trials (EUDRACT), reference number 2013-000583-29 and in clinicaltrials.gov, registration number NCT01816321.


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Model Janica Nam Floresca revealed that she tried to save his life during the incident.
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Janica also shared the happy times they were still together.
It's hard to lose someone you love but it is harder when the one you love the most died in front of you.
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Thomson Reuters says it reduced its annual Greenhouse Gas emissions by 93 percent ahead of Schedule
Targeting 65% of suppliers by spend to have science-based targets by 2025
By Derick Lila April 23, 2021 0
#1 Leading Solar Photovoltaic (PV) Industry-Focused Newswire. We Specialize in News Reports/Analysis and Cutting Edge R&D Discoveries.
Ontario — Thomson Reuters announced it has reduced its annual greenhouse gas (GHG) emissions by 93% from 2018 baseline levels.
The reductions are largely the result of investment in renewable power for the company's facilities through the purchase of renewable energy credits that incentivize the addition of more renewable power into the grid. The company is now ahead of its Science Based Targets initiative (SBTi) commitment to reduce annual GHG emissions by 50% by 2030.
The annual emissions reductions of 94,175 metric tons of Scope 1 (direct operations) and Scope 2 (indirect operations related to energy and heat, etc.) are equivalent to removing 20,346 passenger vehicles from the road annually. In addition to the switch to renewable energy, Thomson Reuters is carbon neutral through the purchase of carbon offsets and has committed to achieving net-zero emissions by 2050 or sooner.
"Despite the pandemic, we've seen tremendous momentum in corporate action on climate change and our company is committed to doing its part," said Steve Hasker, President and CEO of Thomson Reuters. "Reducing our GHG emissions is an important part of our ESG commitments. We are pleased to report that our decision to shift to renewable power has already reduced emissions significantly. Through our work across the entire supply chain, we are committed to doing more."
In 2020, Thomson Reuters joined the SBTi, a partnership between the United Nations Global Compact, Carbon Disclosure Project (CDP), World Resources Institute (WRI) and World Wide Fund for Nature (WWF), to drive climate action in the private sector in support of the goals of the Paris Agreement limiting global temperature warming to 1.5 degrees Celsius above pre-industrial levels. The SBTi requires companies make commitments, register their targets for approval, and report on progress. Thomson Reuters has the following SBTi-approved climate change targets:
– Reducing absolute Scope 1 & 2 GHG emissions by 50% by 2030 from a 2018 base year;
– Reducing absolute Scope 3 GHG emissions from fuel and energy-related activities, business travel and employee commuting by 25% by 2025 from a 2019 base year; and
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Frontline | Press Releases | FRO – Notice of Special General Meeting
FRO – Notice of Special General Meeting
Frontline Ltd advises that its Special General Meeting of Shareholders (the "Special Meeting") to approve the previously announced merger transaction with Frontline 2012 Ltd. will be held at Frontline's offices located at Par-la-Ville Place, 4th Floor, 14 Par-la-Ville Road, Hamilton, HM 08 Bermuda, on Monday, November 30, 2015, at 9:30 a.m., local time. Frontline has fixed the close of business on Monday November 2, 2015 as the record date for the determination of the shareholders entitled to receive notice and vote at the Special Meeting or any adjournments or postponements thereof.
A copy of the Notice of the Special Meeting and the associated prospectus can be found on our website at www.frontline.bm and in the links below.
Important Information For Investors And Shareholders
This communication does not constitute an offer to sell or the solicitation of an offer to buy any securities or a solicitation of any vote or approval. In connection with the proposed transaction between Frontline and Frontline 2012, Frontline has filed relevant materials with the Securities and Exchange Commission (the "SEC"), including a registration statement of Frontline on Form F-4 (File No. 333-206542), initially filed on August 24, 2015 and subsequently amended, that includes a joint proxy statement of Frontline 2012 and Frontline that also constitutes a prospectus of Frontline. The registration statement was declared effective by the SEC on November 9, 2015. A definitive joint proxy statement/prospectus has been mailed to shareholders of Frontline 2012 and Frontline. INVESTORS AND SECURITY HOLDERS OF FRONTLINE 2012 AND FRONTLINE ARE URGED TO READ THE JOINT PROXY STATEMENT/PROSPECTUS AND OTHER DOCUMENTS THAT WILL BE FILED WITH THE SEC CAREFULLY AND IN THEIR ENTIRETY WHEN THEY BECOME AVAILABLE BECAUSE THEY WILL CONTAIN IMPORTANT INFORMATION. Investors and security holders will be able to obtain free copies of the registration statement and the joint proxy statement/prospectus (when available) and other documents filed with or furnished to the SEC by Frontline through the website maintained by the SEC at http://www.sec.gov. Copies of the documents filed with or furnished to the SEC by Frontline will be available free of charge on Frontline's website at http://www.frontline.bm. Additional information regarding the participants in the proxy solicitations and a description of their direct and indirect interests, by security holdings or otherwise, will be contained in the joint proxy statement/prospectus and other relevant materials to be filed with or furnished to the SEC when they become available.
Forward -Looking Statements
Matters discussed in this press release may constitute forward-looking statements. Forward-looking statements include statements concerning plans, objectives, goals, strategies, future events or performance, and underlying assumptions and other statements, which are other than statements of historical facts. Words, such as, but not limited to "believe," "anticipate," "intends," "estimate," "forecast," "project," "plan," "potential," "may," "should," "expect," "pending" and similar expressions identify forward-looking statements.
Forward-looking statements include, without limitation, statements regarding:
The effectuation of the transaction between Frontline and Frontline 2012 described above;
The delivery to and operation of assets by Frontline;
Frontline's and Frontline 2012's future operating or financial results;
Future, pending or recent acquisitions, business strategy, areas of possible expansion, and expected capital spending or operating expenses; and
Tanker market trends, including charter rates and factors affecting vessel supply and demand.
The forward-looking statements in this press release are based upon various assumptions, many of which are based, in turn, upon further assumptions, including without limitation, examination of historical operating trends, data contained in records and other data available from third parties. Although Frontline believes that these assumptions were reasonable when made, because these assumptions are inherently subject to significant uncertainties and contingencies which are difficult or impossible to predict and are beyond the control of Frontline, Frontline cannot assure you that they, or the combined company, will achieve or accomplish these expectations, beliefs or projections. In addition to these important factors, other important factors that could cause actual results to differ materially from those discussed in the forward-looking statements, including the strength of world economies and currencies, general market conditions, including fluctuations in charter rates and vessel values, changes in demand for tanker shipping capacity, changes in the combined company's operating expenses, including bunker prices, drydocking and insurance costs, the market for the combined company's vessels, availability of financing and refinancing, changes in governmental rules and regulations or actions taken by regulatory authorities, potential liability from pending or future litigation, general domestic and international political conditions, potential disruption of shipping routes due to accidents or political events, vessels breakdowns and instances of off-hires and other factors. Please see Frontline's filings with the SEC for a more complete discussion of these and other risks and uncertainties. The information set forth herein speaks only as of the date hereof, and Frontline disclaims any intention or obligation to update any forward-looking statements as a result of developments occurring after the date of this communication.
Frontline Ltd.
This information is subject to the disclosure requirements pursuant to section 5-12 of the Norwegian Securities Trading Act.
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text:
CovidCrossBorders → Spain → Visiting Egypt from Spain
When will Egypt open its borders to Spain and during coronavirus (COVID-19) pandemic in 2021?
2019 divided the history of most countries into «before» and «after». We are talking about a pandemic that has swept the whole world. The SARS-CoV-2 virus was first identified among residents of Hubei province (China). In just a few months, a disease called Covid-19 has spread to the inhabitants of the entire planet. Spain and Egypt were not an exception.
According to current data (statistics for Sunday, 20 June 2021), the number of cases in Egypt is 276 756 people, total deaths are 15 829, and 55 770 are sick right now. Such statistics forced the government of the state of Egypt to impose certain restrictions on flights and border crossing.
Is it allowed to enter Egypt from Spain?
Current statistics on the restrictions on entry to Egypt:
Quarantine (lockdown) in Egypt: Partial
During the most «acute» periods of the pandemic, the following restrictions are applied in Egypt:
Foreigners can enter the territory of Egypt only if absolutely necessary: study in Egypt, employment, residence permit. For more information about the conditions of entry, read the official sources of the government: https://www.reuters.com/article/us-health-coronavirus-egypt-idAFKBN2CM1RM
Availability of the test: Negative PCR test is required for all countries.
In this regard, the government acts in accordance with the recommendations of the World Health Association. The distribution of states into separate categories is updated regularly. At the moment, Spain ranks among the states of the «Green» category.
Rules for entering Egypt from Spain in 2021
At the moment, Egypt is opened to foreigners, including s. Quarantine measures are applied to tourism and trade.
Before travelling to Egypt, s must pass the PCR test no earlier than 72 hours in advance and submit a written document of an international standard (in English). Also, at the time of arrival, there should be no signs of SARS (fever, chills, runny nose, cough, etc.).
Is it necessary to comply with quarantine and take a PCR test when entering Egypt?
Negative PCR test is required for all countries.
Quarantine not required
For which countries are the borders with Egypt open?
Today (Sunday, 20 June 2021) the borders of Egypt are fully open for 51/ 32 countries, partially open for 0/ 32 countries. See how we collect data and find out why not all countries are included in the statistics.
In Egypt, bars and restaurants work with restrictions, all shops work without restrictions. Public events (exhibitions, concerts, museums, etc.) are allowed but with restrictions.
Commercial flights and international tourism to Egypt has resumed from 1 July.Starting September 1, all arriving international travellers, including Egyptian citizens, will need to present a negative PCR test certificate for COVID-19 taken prior to arrival. Currently, PCR tests must be taken within 72 hours before arrival, but on September 1 that requirement will change to no less than 48 hours before arrival. Travellers must present paper copies of the test results; digital copies will not be accepted. Children under the age of six of all nationalities are exempt.
At the moment, there are no other restrictions on entering the territory of Egypt. At the same time, the government recommends waiting for travel to countries with extremely high rates of covid-19 spread (red zone).
Today (Sunday, 20 June 2021) Spain's borders are fully open to 5/ 32 countries, partially open — to 46/ 32 countries. See how we collect data and find out why not all countries are included in the statistics.
List of countries for which the borders with Spain are partially or completely open:
At the moment, there are no other restrictions on entry into Spain. At the same time, the government recommends waiting for travel to countries with extremely high rates of covid-19 spread (red zone).
The cheapest flights to Egypt from Spain
The resumption of full-fledged air communication is gradual. At the moment, direct flights to Egypt are limited, so it is possible to get to Egypt with transfers. We offer the best air fares from Spain to Egypt. Today you have the opportunity to book tickets at an affordable price. A pandemic is not a barrier to business and travel.
Actual data of COVID-19 in Egypt
Current coronavirus statistics in Egypt:
Situation with lockdown in Egypt:
The closing hours of Egyptian stores, malls and restaurants will be brought forward to 9 pm (1900 GMT) to help contain the coronavirus for two weeks from Thursday, straddling the last days of the Muslim holy month of Ramadan and Eid celebrations. Large gatherings and concerts will be banned over the same period and beaches and parks will be shut between May 12−16.Mosques have been open for daily prayers with the exception of Friday prayers. A ban on funerals and marriage ceremonies remains in place.Clubs, coffee shops, and restaurants have reopened with preventative measures in place.Hotels are able to open at 25% capacity.Cinemas and theatres are allowed to reopen at a maximum seating capacity of 25% allowedFace masks are mandatory in most public areas.
Source: https://www.reuters.com/article/us-health-coronavirus-egypt-idAFKBN2CM1RM
However, even in a pandemic, you can leave Spain for Egypt with the necessary permits:


text:
New Insights into Disease Mechanisms New Insights into Disease Mechanisms
Inflammatory Processes Drive Progression of Alzheimer's and Other Brain Diseases. Report in "Nature"
Inflammation drives the progression of neurodegenerative brain diseases and plays a major role in the accumulation of tau proteins within neurons. An international research team led by the German Center for Neurodegenerative Diseases (DZNE) and the University of Bonn comes to this conclusion in the journal "Nature". The findings are based on the analyses of human brain tissue and further lab studies. In the particular case of Alzheimer's the results reveal a hitherto unknown connection between Abeta and tau pathology. Furthermore, the results indicate that inflammatory processes represent a potential target for future therapies.
A microscopic view of a neuron (white), - surrounded by deposits of amyloid-beta protein (red). These deposits trigger neuroinflammation and thus drive progression of Alzheimer's disease. © DZNE/Uni Bonn/Heneka Lab
Tau proteins usually stabilize a neuron's skeleton. However, in Alzheimer's disease, frontotemporal dementia (FTD), and other "tauopathies" these proteins are chemically altered, they detach from the cytoskeleton and stick together. As a consequence, the cell's mechanical stability is compromised to such an extent that it dies off. In essence, "tau pathology" gives neurons the deathblow. The current study led by Prof. Michael Heneka, director of the Department of Neurodegenerative Diseases and Gerontopsychiatry at the University of Bonn and a senior researcher at the DZNE, provides new insights into why tau proteins are transformed. As it turns out, inflammatory processes triggered by the brain's immune system are a driving force.
A Molecular Switch
A particular protein complex, the "NLRP3 inflammasome", plays a central role for these processes, the researchers report in "Nature". Heneka and colleagues already studied this macromolecule, which is located inside the brain's immune cells, in previous studies. It is a molecular switch that can trigger the release of inflammatory substances. For the current study, the researchers examined tissue samples from the brains of deceased FTD patients, cultured brain cells, and mice that exhibited hallmarks of Alzheimer's and FTD.
"Our results indicate that the inflammasome and the inflammatory reactions it triggers, play an important role in the emergence of tau pathology", Heneka said. In particular, the researchers discovered that the inflammasome influences enzymes that induce a "hyperphosphorylation" of tau proteins. This chemical change ultimately causes them to separate from the scaffold of neurons and clump together. "It appears that inflammatory processes mediated by the inflammasome are of central importance for most, if not all, neurodegenerative diseases with tau pathology."
A Link between Abeta and Tau
This especially applies to Alzheimer's disease. Here another molecule comes into play: "amyloid beta" (Abeta). In Alzheimer's, this protein also accumulates in the brain. In contrast to tau proteins, this does not happen within the neurons but between them. In addition, deposition of Abeta starts in early phases of the disease, while aggregation of tau proteins occurs later.
In previous studies, Heneka and colleagues were able to show that the inflammasome can promote the aggregation of Abeta. Here is where the connection to the recent findings comes in. "Our results support the amyloid cascade hypothesis for the development of Alzheimer's. According to this hypothesis, deposits of Abeta ultimately lead to the development of tau pathology and thus to cell death," said Heneka. "Our current study shows that the inflammasome is the decisive and hitherto missing link in this chain of events, because it bridges the development from Abeta pathology to tau pathology. It passes the baton, so to speak." Thus, deposits of Abeta activate the inflammasome. As a result, formation of further deposits of Abeta is promoted. On the other hand, chemical changes occur to the tau proteins resulting into their aggregation.
A Possible Starting Point for Therapies
"Inflammatory processes promote the development of Abeta pathology, and as we have now been able to show, of tau pathology as well. Thus, the inflammasome plays a key role in Alzheimer's and other brain diseases," said Heneka, who is involved in the Bonn-based "ImmunoSensation" cluster of excellence and who also teaches at the University of Massachusetts Medical School. With these findings, the neuroscientist sees opportunities for new treatment methods. "The idea of influencing tau pathology is obvious. Future drugs could tackle exactly this aspect by modulating the immune response. With the development of tau pathology, mental abilities decline more and more. Therefore, if tau pathology could be contained, this would be an important step towards a better therapy."
Publication: Christina Ising et al.: NLRP3 inflammasome activation drives tau pathology, Nature (2019), DOI: 10.1038/s41586-019-1769-z
Dr. Marcus Neitzert
DZNE, Communications
Tel. +49-228-43302-267
E-Mail: marcus.neitzert@dzne.de


Havyard Group has now developed its own concept of navigation and communications packages for vessels. Saeborg B102, which is close to completion, is the first vessel with such an equipment package from Havyard.
The Fosnavåg-based company is currently completing the supply vessel Saeborg B102 at Havyard Ship Technology in Leirvik in Sogn, Norway. And this time Havyard can proudly proclaim that the navigation and communications package is provided by the company itself. This includes Radar, Ecdis, Log, Echo sounder, Autopilot, Conning, VDR, AIS, GPS, etc.
- We have worked quite a while in order to develop the concept of NavCom packages and this is the first delivery that shows that we have reached our development goal and can offer a complete and proven concept to our customers, says Executive Vice President of Havyard Global Solutions, Gunnar Larsen.
Havyard also offers this concept within design and system packages being delivered to shipyards and shipowners that are building Havyard designTM at other shipyards in Norway and internationally. Havyard delivers products and services for the entire value chain within ship technology, from design and engineering, shipbuilding competence and expertise, purchasing and logistics, project management and operational support to ships.
And at the shipyard in Leirvik both employees and management are proud to have reached their target.
- Yes, we are definitely a little proud now. The installations are quite extensive in regards to these Naut-ships, and we have done everything from the planning to documentation and implementation, says Svein Olav Tørresdal, Project Manager Nav/Com at Havyard Power & Systems.
Earlier this week Havyard carried out thorough tests of the Saeborg B102 and all of its equipment at sea, in the waters near the Leirvik shipyard.
- It looks very promising, and the plan now is to continue this type of work on all new vessels from Havyard. We have already ordered equipment for the next three vessels 102, 103 and 106, says Tørresdal, and adding that Havyard this spring also performed a successful conversion for Petrobras on B105 in Leirvik. - This was another very successful project of which both Havyard and the shipowners Garware were very satisfied, says Tørresdal, who came to Havyard Group from the company Vico AS in Haugesund one year ago.
The man from Haugesund thrives in his new position in Havyard Group. - It really is such an exciting company to work for. There are constant and endless possibilities and challenges within the Havyard Group. I like things to happen and they certainly do in Havyard, says Tørresdal and smiles.


text:
Q: Making tables with \multicolumn I've made the following table using \multicolumn. Everything looks fine. Unfortunately when I replace A, B or C with some longer text, I get unequal spacing between the three columns below. Can anyone explain me why?
\begin{table}[h!]
  \centering
    \begin{tabular}{|ccc|ccc|ccc|c|}
    \toprule
\multicolumn{3}{|c}{Longer text} & \multicolumn{3}{|c}{B} & \multicolumn{3}{|c}{C} &\multicolumn{1}{|c|}{D} \\
    \midrule
    a & b & c & a & b & c & a & b & c & \multicolumn{1}{c|}{} \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 & \multicolumn{1}{c|}{4}\\
     a & b & c & a & b & c & a & b & c & \multicolumn{1}{c|}{} \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 & \multicolumn{1}{c|}{}\\
\cline{1-9}
    \multicolumn{3}{|c|}{A} & \multicolumn{3}{c|}{B} & \multicolumn{3}{c|}{C} & \multicolumn{1}{c|}{} \\
\cline{1-9}
     a & b & c & a & b & c & a & b & c & \multicolumn{1}{c|}{} \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 & \multicolumn{1}{c|}{}\\
     a & b & c & a & b & c & a & b & c & \multicolumn{1}{c|}{} \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 & \multicolumn{1}{c|}{}\\
    \bottomrule
    \end{tabular}
\end{table}

A: Some propositions: Remove the vertical lines and use a C{0.3cm} etc. columntype in conjunction with the *{3}C{} repetition codes, to ease the use of such column beasts:
\documentclass{article}
\usepackage{array}

\usepackage{booktabs}

\newcolumntype{C}[1]{>{\centering}p{#1}}
\newlength{\stdcolumnwidth}
\setlength{\stdcolumnwidth}{0.3cm}

\begin{document}

\begin{table}[h!]
  \centering
    \begin{tabular}{*{3}{C{\stdcolumnwidth}}*{3}{C{\stdcolumnwidth}}*{3}{C{\stdcolumnwidth}}c}
    \toprule
    \multicolumn{3}{c}{Longer text} & \multicolumn{3}{c}{B} & \multicolumn{3}{c}{C} &D \\
    \midrule
    a & b & c & a & b & c & a & b & c & \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 & 4\\
    a & b & c & a & b & c & a & b & c & \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 & \\
    \midrule
    \multicolumn{3}{c}{A} & \multicolumn{3}{c}{B} & \multicolumn{3}{c}{C} &  \\
    \midrule
    a & b & c & a & b & c & a & b & c &  \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 &  \\
    a & b & c & a & b & c & a & b & c &  \\
    1 & 2 & 3 & 1 & 2 & 3 & 1 & 2 & 3 &  \\
    \bottomrule
    \end{tabular}
\end{table}

\end{document}

A: Your problem arise when the  width of text in multicolumn cell is wider than sum of longest text of belonging columns (see figure below). In this case first two columns have natural width, but third one accommodate its width to width requested by multicolum cell.
This problem can be solved on different ways, among them the following two are relative simple, however both require manual tweaking of columns width. In both the table columns are divided into groups (as suggest Christian Hupfer in his answer). With this you have the columns width in the columns, where arise your problem. Proposed solutions are:

*

*you adjust width of columns in the group where the your problem arise for amount, that widths of all belonging columns are equal

*make text in multicolumn cell narrower with breaking it into more lines so, that it can be fit in available width for multicolum cell.

*of course, both aforementioned approach can be combined in searching a compromise for better looks of table
The problem and first two mentioned solution illustrate MWE below:
\documentclass{article}
    \usepackage{array,booktabs,makecell}
    \usepackage{stackengine}
\renewcommand\theadset{\normalsize\renewcommand\arraystretch{.85}}
\newcolumntype{C}[1]{>{\centering\arraybackslash}p{#1}}

    \begin{document}
    \centering
demonstrate the problem\\
\begin{tabular}{|*{3}{C{4mm}|}*{3}{C{4mm}|}*{3}{C{4mm}|}c|}
    \toprule
\multicolumn{3}{|c|}{Longer text}
            &   \multicolumn{3}{c|}{BBBB BBB BB BBBBB}
                            &   \multicolumn{3}{c|}{C}
                                            & D   \\
    \midrule
a & b & c   & a & b & c     & a & b & c     &     \\
1 & 2 & 3   & 1 & 2 & 3     & 1 & 2 & 3     & 4   \\
    \bottomrule
\end{tabular}

\medskip
first possible solution\\
\begin{tabular}{|*{3}{C{4mm}|}*{3}{C{10mm}|}*{3}{C{4mm}|}c|}
    \toprule
\multicolumn{3}{|c|}{Longer text}
            & \multicolumn{3}{c|}{BBBB BBB BB BBBBB}
                            & \multicolumn{3}{c|}{C}
                                            & D   \\
    \midrule
a & b & c   & a & b & c     & a & b & c     &     \\
1 & 2 & 3   & 1 & 2 & 3     & 1 & 2 & 3     & 4   \\
    \bottomrule
\end{tabular}

\medskip
second possible solution\\
\begin{tabular}{|*{3}{C{4mm}|}*{3}{C{4mm}|}*{3}{C{4mm}|}c|}
    \toprule
\multicolumn{3}{|c|}{Longer text}
            & \multicolumn{3}{c|}{\thead[b]{BBBB BBB\\ BB BBBBB}}
                            & \multicolumn{3}{c|}{C}
                                            & D   \\
    \midrule
a & b & c   & a & b & c     & a & b & c     &     \\
1 & 2 & 3   & 1 & 2 & 3     & 1 & 2 & 3     & 4   \\
    \bottomrule
\end{tabular}
    \end{document}

Package makecell is added for second solution, where is used macro thead from this package. For illustration I consider only first three rows from table.

redpajama_set_name: RedPajamaStackExchange


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text:
Here's Why Google Fiber Could Be Virtually Uncontested in the Fiber Internet Market
Google Fiber, while groundbreaking and high-performing, is by no means the only fiber optic internet service available. However, there's reason to believe Google Fiber will dominate the fiber industry in the future.
Michael Nielsen
(MichaelPNielsen)
Jul 17, 2014 at 7:00PM
Michael is a full-time MBA student and certified stock market junkie. For the Fool, he writes articles about the telecom industry. To see some of his market-beating investment ideas, follow him on twitter Follow @BeatSP500
Google (NASDAQ:GOOG)(NASDAQ:GOOGL) Fiber... What an awesome concept. An Internet connection speed that is up to 100 times faster than today's average broadband.
Google Fiber is pretty awesome -- but it is by no means the only fiber optic Internet service available. Verizon (NYSE:VZ) has FiOS, Comcast offers fiber optic Internet to businesses, and AT&T (NYSE:T) offers a fiber optic based Internet called U-verse with Gigapower. But there is a big difference between Google and traditional Internet service providers, and the difference could serve as a springboard for Google to dominate the fiber optic Internet market in the future.
What separates Google from its fiber competitors?
Let's think about the difference between Google and the big names in the telecom industry. First of all, Google is just entering the Internet service providing (ISP) industry: its first connection was made in 2011. That means the fiber optic cables that were laid down to connect Google Fiber to homes and businesses were on fresh soil untouched by Google.
In contrast, the big players in the ISP industry have huge networks of twisted copper wire sprawling across the country that connect their customers with broadband and DSL. So to build a network of fiber optic Internet, the seasoned ISPs will often drive in equipment, tear up streets, and lay down fresh fiber optic cables right next to their existing network of twisted copper wires.
Lack of ROI for the big ISP players
Obviously, tearing up neighborhoods to install thousands of miles of fiber is an expensive endeavor, an investment that many ISPs are not capable of funding. And in many cases, installing fiber could cannibalize their existing market share. Needless to say, the ROI of a fiber network would be slim to nil for most ISPs.
The ROI conundrum faced by normal ISP's is the reason Verizon shelved its FiOS expansion plans in 2010. And also why Verizon's CFO said "I am not going to build beyond the current LSAs that we have built out" at the Deutsche Bank Media, Internet and Telecom Conference this year.
Unlike Verizon, Google doesn't have a network of twisted copper wires. And Google doesn't have an existing stream of revenue from broadband or DSL. When Google lays down fiber, it doesn't have to worry about cannibalizing its own business. Each new connection results in new revenue -- a sound investment that will generate free cash flow it can use to organically expand its fiber network.
Why ISP investors should pay heed
Google has made some serious headway in the four years it has operated its Fiber service. Google Fiber is currently available in the Kansas City Metro Area, Austin, TX, and Provo, UT. And Google plans to expand its Fiber service to eight new metropolitan areas within the next few years.
Credit: Google Maps
Goldman Sachs projects that Google Fiber could connect 830,000 homes per year and could reach nearly 8 million homes by 2022.
If ISPs aren't careful, Google could dominate the fiber market and take away their existing broadband and DSL subscribers.
Investors' takeaway
The bottom line is, if you're a Google investor, you should be pleased with the Fiber project. It has serious potential to create a large stream of revenue for Google and boost its advertising and merchandise sales. If you're a traditional ISP investor, you should pay attention to what Google does next. Google Fiber truly has the potential to change everything in the ISP market.


text:
PDC Asia
1:49 pm, December 6, 2018
Nitin Kumar looking to "cause trouble" at PDC World Championship
He has yet to step onto the Alexandra Palace oche for the first time. But Nitin Kumar's PDC World Championship chances are already being written off.
Kumar, the World Championship qualifier from India, faces Jeffrey de Zwaan in the first round. Rob Cross awaits the winner. And there is already plenty of buzz surrounding the prospect of the current PDC world number facing renowned giant-killer de Zwaan. But that discounts Kumar – the 33-year-old will be looking to make himself known in London.
"He's a great player," Kumar said of De Zwaan in a Darts Actueel interview.
"I feel that he will become one of the best players in the world in the coming years.
"I do think that if I play at my best and make the most of mistakes he makes, I can cause him trouble. That would be interesting."
Kumar has some stage experience, having appeared at the PDC World Cup of Darts. He also attended two PDC Asian Tour events in 2018. But the Coimbatore-born thrower admits that the World Championship is another matter entirely.
"It's very different from the two PDC World Cups I've played before," he admitted.
"I go there with a mindset that I have to do my utmost. Every game on stage helps me to make mentally better and brings me to a higher level.
"That is what the plan is to do in London."
Kumar confirmed that his post-World Championship plans are already wrapped up, no matter what happens at the Alexandra Palace.
"I'll be participating in Q-School next year.
"I know what the level is to grab a Tour Card during Q-School. I also know that I can play at that level.
"For me it is more to maintain my composure and to throw at a constant level."
Photo: PDC Asia
Tags: Jeffrey de Zwaan, Nitin Kumar, PDC, PDC World Championship 2019
Author: Ed McCosh


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text:
Francis, the people´s Pope
Documentaries • 53m
On March 13, 2013, cardinals stunned the world when they elected Pope Francis, the first Latin American Pope. But why did they see in the 76-year-old Jesuit? Who is Jorge Mario Bergoglio?
ROME REPORTS travels to Argentina to investigate and discover the life that shaped Pope Francis.
Through unedited testimonies, we hear from those who know him best, those who lived with Bergoglio. From his only living sister, Maria Elena, to his successor as superior-general of the Jesuits in Argentina. Hear from a priest who worked with Bergoglio in the country's slums, and from the corner vendor who for years, sold him the daily newspaper. Meet the young man who overcame his addictions with support from the man the world now calls "the Pope".
The documentary begins with the moment a young Jorge Mario discovers his priestly vocation. Decades would pass and a historic conclave would forever change his life, and mark the history of the Catholic Church.
Trailer · Bad apples
Referring to clerical sex abuse, Pope Benedict XVI said, "The greatest persecution of the Church does not come from external enemies, but is born of sin within the Church. Thus the Church has a profound need to relearn penance, purification, forgiveness and justice."
In BAD APPLES, television ...
Bad Apples: Dealing with Sex Abuse in...
In "BAD APPLES", televisio...
Trailer · John Paul the Great
This moving retrospective on John Paul II follows the story of his life, from his youthful days in Poland to his entry into the priesthood to his long and legendary papacy.
Witness highlighted moments that made history and touched millions around the world in this sentimental look at one of th...


text:
And Now … Ireland: Pension Reserve Funds To Be Spent On The Banksters
November 27, 2010 November 27, 2010 by Infinite
Wake up Ireland and watch this:
– Jesse Ventura Conspiracy Theory: Wall Street
UP to €15 billion from the National Pensions Reserve Fund, set aside when the Celtic Tiger was still roaring, is likely to be used to recapitalise three of the country's banks.
Amid speculation last night that the rate of interest to be charged on the EU/IMF bailout could be as much as 6.7%, Fine Gael's finance spokesman Michael Noonan said that kind of rate was "far too high" and unaffordable on any reasonable projection of growth.
The Department of Finance said the interest rate had still not been finalised, but given that much of the loan would be repayable over nine years the rate could be higher than the 5.2% charged to Greece but would not be as high as the 6.7% being quoted by some brokers.
Meanwhile, Anglo Irish Bank, which was downgraded to junk status yesterday evening, is expected to be closed swiftly, together with the Irish Nationwide Building Society, under the EU/IMF loan plan.
Officials hope to finalise the details of the €85bn package later today and have EU finance ministers approve it tomorrow.
The emphasis in the plan is to avoid drawing down money from the bailout and rely in the first place on money from the Pension Reserve Fund for the banks, and on the €20bn the state borrowed earlier this year to part-fund next year's national budget.
Economist at the Economic and Social Research Institute, John FitzGerald, said he believed it would be a good idea to use the money in the pensions fund to recapitalise the banks, and keep the EU/IMF funds in reserve in case they needed further money later.
"Using the €20bn in cash we have first would be good for the country in the short run. It would leave the opening debt for 2012 €20bn lower and interest payments would be €1bn less. It would also leave the national debt lower than forecast at the end of next year," he said.
About €35bn of the total EU/IMF loan was being earmarked last night for the banks.
The Government would prefer not to tap this sum but keep it in reserve for contingencies during the three-year programme.
Instead, they will use the €15bn available to them in the pension fund to recapitalise Allied Irish Bank, Bank of Ireland and the Educational Building Society. They have already used the remaining €10bn from the pension fund to buy shares in AIB and BoI.
The Government had planned to split Anglo Irish Bank, which has already received €22.9bn of state money, into a bad bank destined to be shut down relatively quickly and a good bank that would hold the deposits Anglo still had.
The European Commission, however, said while the good bank could hold the deposits, it could not operate as a bank and must be shut down over the next decade. Now, however, under the terms being worked out with the EU/IMF/ECB team, the entire operation is likely to be shut down but it could still cost several more billions of euro to do so.
The Irish Nationwide Building Society, into which the state pumped €2.7bn, will also shut.
Since Allied Irish Bank has been unable to raise the €10.4bn it needs to recapitalise, the pension fund money will be used instead, while strengthening the also nationalised Bank of Ireland will cost about €1.5bn.
About €50bn is expected to be available from the EU- IMF package to cover the country's funding needs over the next three years. But it is likely that the Government will first use the €20bn it raised on the markets over the summer.
If the markets have calmed and reduced Ireland's borrowing costs closer to the 4.8% it averaged this year and last, the exchequer may decide to return to the markets rather than tap what could be more expensive money from the EU/IMF bailout.
Picture: Fine Gael's finance spokesman Michael Noonan
This story appeared in the printed version of the Irish Examiner Saturday, November 27, 2010
By Ann Cahill, Europe Correspondent
Source: The Irish Examiner
Categories Economy, Global News, Politics, Society Tags Anglo Irish Bank, Bailout, Banking, Economy, EU, Europe, Global News, Government, IMF, Ireland, Pension, Politics Post navigation
US warns Britain over new WikiLeaks revelations that will 'expose corruption between allies'
War Machines: Recruiting Robots for Combat


A load of people faced with a worry about their propeller just take their boat to a machinist or the city distributor where they bought their boat and wind up spending a lot more money than they ought to or wind up getting the wrong pitch prop for their boat. You don't have to if you know what to seek out and where to get it fixed. A highly recommended propeller repair shop is Bobby Soles Propeller 1730 Hill ave. West Palm Beach, Florida 33407 and they offer repair by mail service with quick turn around time to get you back on the water in fast.


This new first edition guide introduces two exotic destinations fast becoming required stops for globetrotting tourists. Through our expert author, readers are exposed to the rich culture and poignant history in Cambodia and Laos. Discover the region's food and gift markets, lovely beaches and islands, colorful temples, and charming villages.
This title covers highlights of both countries, including Cambodia's tourist Mecca and spiritual center Angkor Wat, capital Phnom Penh, and beach resort Sihanoukville. Laos covers the relaxed city Vientiane, Luang Prabang (a UNESCO World Heritage city for its blend of Laotian and European architecture), and top spots for ecotourism. The planning chapter includes extensive information on sustainable development and volunteer vacations. Special features include a Khmer and Laotian language primer and separate history and culture chapters for both nations.


text:
Links
*****

- `Short introduction to log4j`_

Alternatives
============

- `Logback is intended as a successor to the popular log4j project`_.
- `Simple Log is a logging anti-framework`_.

Analyzer
========

- `Real time Java server logs in your web browser`_
- Chainsaw_
- http://mindtreeinsight.sourceforge.net/
- Beanmill_
  A component to visualize Log4J, JSR47 Logging Events (over Sockets) in your
  favourite IDE.
- http://github.com/tobi/clarity
  Web interface for the ``grep`` and ``tail -f`` unix tools.
  Useful for real-time log analysis.

.NET
====

- `log4j for .NET`_

email
=====

- `Sending Email Using Apache Log4J`_

Extras
======

- `log4j - Extras`_
- `LogWeb is a web interface for configuring Log4J at runtime within a servlet container`_.
- http://logdigger.com/

Facade
======

- `Simple Logging Facade for Java (SLF4J)`_
- SLF4J - Getting started, :doc:`../slf4j/getting-started`.

Learning
========

- `Log4j Tutorial: Additivity – what and why?`_
- `Reporting Application Errors by Email`_
- `Build Flexible Logs With log4j`_
- `Effective logging practices ease enterprise development`_
- `Log4j Tutorial`_

Web
===

- `How to setup Log4j in a web app`_
  (includes an example XML configuration).

.. _`Short introduction to log4j`: http://logging.apache.org/log4j/docs/manual.html
.. _`Logback is intended as a successor to the popular log4j project`: http://logback.qos.ch/
.. _`Simple Log is a logging anti-framework`: https://simple-log.dev.java.net/
.. _`Real time Java server logs in your web browser`: http://logdigger.com/solutions/real-time-java-server-logs-in-your-web-browser
.. _Chainsaw: http://logging.apache.org/chainsaw/index.html
.. _Beanmill: http://blogs.cismet.de/gadgets/beanmill/
.. _`log4j for .NET`: http://logging.apache.org/log4net/index.html
.. _`Sending Email Using Apache Log4J`: http://www.hiteshagrawal.com/java/sending-email-using-apache-log4j
.. _`log4j - Extras`: http://logging.apache.org/log4j/companions/extras/
.. _`LogWeb is a web interface for configuring Log4J at runtime within a servlet container`: http://www.codeczar.com/products/logweb/
.. _`Simple Logging Facade for Java (SLF4J)`: http://www.slf4j.org
.. _`Log4j Tutorial: Additivity – what and why?`: http://veerasundar.com/blog/2009/08/log4j-tutorial-additivity-what-and-why/
.. _`Reporting Application Errors by Email`: http://www.onjava.com/pub/a/onjava/2004/09/29/smtp-logging.html
.. _`Build Flexible Logs With log4j`: http://www.onjava.com/pub/a/onjava/2002/08/07/log4j.html
.. _`Effective logging practices ease enterprise development`: http://www-128.ibm.com/developerworks/java/library/j-logging/
.. _`Log4j Tutorial`: http://www.vaannila.com/log4j/log4j-tutorial/log4j-tutorial.html
.. _`How to setup Log4j in a web app`: https://www.burlesontech.com/wiki/display/btg/How+to+setup+Log4j+in+a+web+app+-+fast

redpajama_set_name: RedPajamaGithub


Some things significant you will need initially in order to make a home is really suggestions and inspirations. Mainly because without suggestions and inspirations, the home can be seems to be conceptless and also not appealing. Old Man Praying image gallery will be the correct place for you personally who are searching for inspirations associated with residence creating. Mainly because Old Man Praying photo gallery offers many options of wonderful property as well as interior design principle. It is possible to pick which one that suits you. This Old Man Praying Old Man Praying By Daniphoto ... photos is definitely desired by simply a lot of people. it is not necessarily with out reason, mainly because Old Man Praying Old Man Praying By Daniphoto ... photograph can give you a thought regarding exactly how great houses need to be developed.
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text:
package it.polito.ai.polibox.web.controllers.inputform.validation;

import it.polito.ai.polibox.web.controllers.inputform.SharingInput;

import org.springframework.validation.Errors;
import org.springframework.validation.Validator;

public class SharingInputValidator implements Validator {

	public SharingInputValidator() {
	}

	public boolean supports(Class<?> clazz) {
		return SharingInput.class.equals(clazz);
	}

	public void validate(Object target, Errors errors) {
		SharingInput input=(SharingInput) target;
		if(input == null){
			errors.reject("sharingInput.notnull");
			return;
		}
		if(input.getMode() == null){
			errors.reject("sharingInput.notnull");
			return;
		}
		if(input.getMode().intValue()!=1 && input.getMode().intValue()!=2)
			errors.reject("sharingInput.invalid");
	}

}


text:
Q: "docker run -p" assigned the localhost IP but did not effect on Macos I use the following command to create a container on MacOS,my docker version is "Docker for Mac",
docker run -itd --name dns-mysql1  --network=host  -p 192.168.43.178:53:53 brilliance/dns-mysql:latest

but when it starts,it does not affect,the mapped port and IP address has changed,
As follows:

but it does work on Ubuntu or other Linux system. I want to know why.


Spacious, period, ground floor therapy room with free private parking & near to town centre.
Would suit fully insured and professionally registered Talk and CAM therapists from a wide range of disciplines.
We're specialists in helping people sell homes quickly for the best possible price and we're confident we can do that for you.
Hey Buddy!, I found this information for you: "En Suite Room In Clean Shared House, Botley". Here is the website link: https://oxfordlocals.com/ad/en-suite-room-in-clean-shared-house-botley/. Thank you.


QUICK & EASY TO USE: This instant food chopper will provide you with quick chopped food in seconds, and the best part about it is that it's easy to use.
ERGONOMIC HANDLE: It has been designed to make it 100% Ergonomic for anyone to use.
MILITARY-GRADE PARACHUTE NYLON CORD: This lightweight food chopper has a strong military-grade parachute nylon cord to make sure it's 100 percent durable at all time.
NO LOUD NOISES: Most food choppers are extremely loud, and bother everyone around you. It works it's magic, silently.


The first and most important for the owner of the shop - profits arising from business income.
Currently widely: the highest yield from a square meter of sales area is achieved in the stores with self-supermarkets. Hence the desire of the owner of the shop in this way to organize his work.
1. The server database stores all data on the shop (chain stores). Data are continuously updated, added new - it is important to ensure high performance and reliable access from all the jobs the shop (chain stores). To do this job databases online version TCU organized on the basis of SQL-server (including Microsoft SQL Server). For a store to install MS SQL Express (restriction of the database up to 4 GB), which is distributed free of charge. Provide free version of MS SQL database volume is sufficient to store data for 1 - 5 years, the number of titles in the 5-10 thousand Everything depends on the number of sales (data checks), parishes / expenses, and other things. After filling in all the allowable level of SQL-server, you can remove the (pre-make a backup copy) the old record - a year or more - and continue to work.
Detailed Outline of the database server (hereinafter database) is shown below.
fixed cost savings (low budget) you can combine the database server and workstation. The following is a budget version - both a server job. This allows you to save on the cost of a PC, but reduces the speed of the server - the option of work is avoided!
2. At a regular job (based on TCU version «TCU Network» - «TCU Ultra») can be the introduction of a new product, posting goods received from the supplier, as the mutual interaction with suppliers and any other contractors.
3. workplace cashier (or Cash ) can be organized on the basis of any PC or laptop. It is desirable to equip the workplace of the cashier a special keyboard (keyboard programming). Programmable keyboard is more durable than conventional (it is designed for a long period of intensive exploitation), and may also be reprogramme the commission of various acts in a sequential pressing.
cash job done with the scanning of goods recorded in the "check" and the introduction of quantity, printing checks, receive cash.
Ukraine in small shops and supermarkets, liquor-vodka department, usually reserved for a separate legal entity. It is connected with a particular tax policy. Shop from the main food group is not a VAT payer, a liquor-vodka Division, attached to another entity, is a VAT payer. As is typically solved this problem?
In TCU3 record total food and liquor group and vodka group conducted at selected outlets that entirely legitimate. Each outlet has its own tax details, and often different owners.
Workplace cashier ShopDesk configurable access to both outlets. One of them (liquor-vodka products) is configured as a «tax».
If the buyer acquires only common food products group, only the non-fiscal receipt is printed with the amount of purchase.
If a buyer acquires goods and general food groups, and liquor-vodka products, tax receipt includes only «liquor-vodka», a non-fiscal check includes all the goods - and «liquor-vodka», products and general food groups . In this case, the buyer is a general check (non-fiscal) for the full amount of purchase, and attached to the tax check.
other words for a cashier job (his desk, cash box), it is possible to register the sale as one outlet (fiscal products, fiscal receipts) and the other outlet (non-fiscal products, non-fiscal receipts). When the number of «combined» legal retail outlets is not limited.
only condition (at least in Ukraine): at each outlet with VAT => a fiscal printer (fiscal recorder) - the requirements of the legislation.


text:
MLB stadium workers balk at rule to work through national anthem
Ticket-takers at the home stadium of the Anaheim Angels baseball team have reportedly objected to the team's demand to work through the singing of the national anthem.
ABC7.com reported Thursday that employees of Angel Stadium -- based in Anaheim, Calif. -- were told that the new measure would help keep the crowd moving and improve security. The workers, however, say the directive is disrespectful.
"They've always stopped," Jeff Froehlich, a representative from the Service Employees International Union, with represents the workers, told the station. "They would like to see that tradition continued."
The report said that the Angels agreed to -- at least temporarily -- allow these workers to stop during the anthem and will seek alternative measures.
See the Full Story at FoxNews.com
Woman shot in front of her DC home was unintended target, police say
Teenager shot outside of Northeast DC school


Commercial truck drivers cannot legally drive on public roads until they have successfully completed special safety training. Because a fully loaded commercial truck can weigh 80,000 pounds or more, the slightest error can be fatal. It is easy to see how serious injuries and wrongful death might happen. If you are the driver of an automobile, always use caution when sharing the highway with a big rig.
The Federal Motor Carrier Safety Administration regulates operations for commercial truck drivers, providing comprehensive rules for both drivers and motor carriers to follow. We have identified the regulations that are important in most truck accident cases. Explore the following links for appropriate regulations in your case.
PART 391—QUALIFICATIONS OF DRIVERS AND LONGER COMBINATION VEHICLE (LCV) DRIVER INSTRUCTORS.
This defines the qualifications for drivers. Based on the minimum standards, drivers are not fit in many cases.
PART 392—DRIVING OF COMMERCIAL MOTOR VEHICLES.
This section regulates trip inspections, the physical condition of the driver, and other important standards.
This part deals with necessary safety requirements for the condition of commercial vehicles, including brakes, lighting and warning reflectors.
Here you will find the maximum on duty and driving hours a driver can log.


text:
Pargny-sur-Saulx é uma comuna francesa na região administrativa de Grande Leste, no departamento Marne.

Comunas de Marne (departamento)

redpajama_set_name: RedPajamaWikipedia


About three weeks ago, we brought you all of the details on the DVD and Blu-ray release of director Joss Whedon's record breaking superhero team-up, The Avengers. Now we have the official trailer for the September 25th release, which you can check out below, along with all of the options to pre-order your copy.
Check out the details on the DVD and Blu-ray options for The Avengers below!
Pre-order your Collector's set below, or scroll down for some more financially friendly options!
BURBANK, Calif. June 29, 2012— Coming this fall, the third highest-grossing movie of all time and the #1 movie in the world, "Marvel's The Avengers" assembles as you've never seen it before on Blu-ray 3DTM, Blu-rayTM, DVD, Digital and On-Demand platforms on September 25, 2012. In anticipation of this release, Marvel is also launching an all-new App in July – "The Avengers Initiative: A Marvel Second Screen App" (available for the first time on iPhone) – that gives fans unprecedented access to exclusive content building up to the home entertainment release.
The announcement comes as "Marvel's The Avengers" crossed the incredible $600 million domestic box office threshold on June 26 – only the third film in history to do so. It has now grossed an estimated $1.44 billion globally.
Providing viewers with the ultimate in-home experience, the premium 4-Disc Blu-ray Combo Pack provides 5-unique ways to enjoy "Marvel's The Avengers" (on Blu-ray 3D, Blu-ray, DVD, Digital Copy and Digital Download of "Avengers Assembled" Music from and inspired by the film) and brings to life the Super Hero team-up of a lifetime in a whole new dimension on Blu-ray hi- def with stunning visual effects, superior sound and unparalleled bonus content.
Extras include a gag reel, a first for a Marvel Studios film, the chance to hear from the cast and Joss Whedon on their experiences in bringing these larger than life characters to the big screen, a behind-the-scenes look at the groundbreaking visual effects and stunning cinematography, the creation of S.H.I.E.L.D.'s Helicarrier, Soundgarden's "Live to Rise" Music Video, deleted scenes and more!
Also for the first time ever, fans will be able to enjoy even more of the Marvel Universe via the all-new "The Avengers Initiative: A Marvel Second Screen App." By downloading this onto a secondary device, consumers will be able to gain unprecedented access to exclusive content building up to the home entertainment release on September 25. Pieces will be unleashed bi- weekly in July & August and weekly in September leading up to a full immersive experience accompanying the film on Blu-ray. Content includes special access to the S.H.I.E.L.D. database, becoming a S.H.I.E.L.D. agent, invitations to "special missions" either remotely or in the field, links to character profiles, stories and scenes, interactive Marvel digital reader comic books and more. App owners will receive push notifications whenever new content is uploaded and available for their viewing.
Marvel Studios presents "Marvel's The Avengers"—the team up of a lifetime, featuring iconic Marvel Super Heroes Iron Man, The Incredible Hulk, Thor, Captain America, Hawkeye and Black Widow. When an unexpected enemy emerges that threatens global safety and security, Nick Fury, Director of the international peacekeeping agency known as S.H.I.E.L.D., finds himself in need of a team to pull the world back from the brink of disaster. Spanning the globe, a daring recruitment effort begins.
Starring Robert Downey Jr., Chris Evans, Mark Ruffalo, Chris Hemsworth, Scarlett Johansson, Jeremy Renner and Tom Hiddleston, with Stellan Skarsgard and Samuel L. Jackson as Nick Fury, and directed by Joss Whedon, "Marvel's The Avengers" is based on the ever-popular Marvel comic book series The Avengers, first published in 1963 and a comics institution ever since.
"Marvel's The Avengers" is presented by Marvel Studios in association with Paramount Pictures. The film was produced by Marvel Studios' President Kevin Feige and executive produced by Alan Fine, Jon Favreau, Stan Lee, Louis D'Esposito, Patricia Whitcher, Victoria Alonso and Jeremy Latcham. The story was by Zak Penn and Joss Whedon and the screenplay was by Joss Whedon.
Distributed by Walt Disney Studios Motion Pictures, the film smashed the industry record for the biggest domestic opening of all time with $207.4M, crossed the $1 billion global box office threshold in 19 days, and currently stands as the #3 global and domestic release of all time.
Marvel Entertainment, LLC, a wholly-owned subsidiary of The Walt Disney Company, is one of the world's most prominentcharacter-based entertainment companies, built on a proven library of over 8,000 characters featured in a variety of media over seventy years. Marvel utilizes its character franchises in entertainment, licensing and publishing. For more information visit www.marvel.com.
For more than 85 years, The Walt Disney Studios has been the foundation on which The Walt Disney Company was built. Today, the Studio brings quality movies,music and stage plays to consumers throughout the world. Feature films are released under the following banners: Disney, including Walt Disney Animation Studios and Pixar Animation Studios; Disneynature; Marvel Studios; and Touchstone Pictures, the banner under which live-action films from DreamWorks Studios are distributed. The Disney Music Group encompasses the Walt DisneyRecords and Hollywood Records labels, as well as Disney Music Publishing. The Disney Theatrical Group produces and licenses live events, including Disney on Broadway, Disney On Ice and Disney Live!.
The Avengers directed by Joss Whedon and starring Robert Downey Jr., Scarlett Johansson, Chris Evans, Chris Hemsworth, Mark Ruffalo, Samuel L. Jackson, Jeremy Renner, Clark Gregg and Tom Hiddleston is in theaters now, and available for pre-order on DVD and Blu-ray.