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Home > Formula One > Sainz targets top 10 finish in first Abu Dhabi race
Sainz targets top 10 finish in first Abu Dhabi race
Having lost out to Force India for fifth place in the constructors' championship and left to fight Lotus for sixth, Carlos Sainz Jr. wants Toro Rosso to be on the heels of the front-runners this weekend at the Yas Marina circuit.
Sainz failed to start the Brazilian Grand Prix a fortnight ago due to an electrical problem, so he is keen to make up for lost points.
"I think the realistic expectation is to be the fifth car. The other cars obviously they have had a massive step forward during the season and they look to be one step ahead of us now. But to be in the top 10/top 9 would be the objective," Sainz said.
"Last year the car here was quite strong, looking at the results and the pace of [Daniil] Kvyat, they were quite strong, even though this year the power deficit is bigger and the straights are quite long. I think we can challenge in the first and last sector to get back the time we lose in the second sector," he added.
Although this is Sainz's first full season in Formula 1, the Yas Marina circuit isn't an unfamiliar track for the Spaniard, as he tested here 12 months ago for Red Bull Racing which propelled his career forward into F1.
"The year has gone by really, really quick. It's incredible that we're in Abu Dhabi now, its eight months since the first race and it's exactly 12 months since my test with Red Bull that changed my life. So it's incredible to be here with a smile on my face after a very decent year, I'm a very happy guy to complete my first year in Formula 1."
Sainz, along with his team-mate Max Verstappen, have been outstanding additions to the Formula 1 roster in their rookie seasons. Never mind the amount of points finishes both have scored and pure pace they have displayed over the weekends, but both have proven themselves worthy racers with their impressive overtakes over the season.
So it doesn't come as much of a surprise that Sainz isn't fazed by the task over making his way through the field if he fails to reach Q3 on Saturday.
"Looking at last year, the guys who didn't start in the top ten had a massive advantage by not starting on the super softs and by having an alternative strategy, a bit like what could have happened in Brazil when there's such a big difference, but when the option tyre doesn't work so well it gives you a big advantage.
"You can start on a new tyre, even if you are 11th or 12th, so if you are following other cars you have the opportunity to change the strategy. Personally, it's always nicer to go into Q3, the feeling of that, even if you start 10th or 9th instead of 11th, to go into Q3 is always better."
Image via Red Bull Content Pool
Josh Kruse
Latest posts by Josh Kruse (see all)
Join our writing team! - 20 February, 2017
Manor F1 team folds after no buyer found - 27 January, 2017
Formula 1 amends on-track collision penalties - 25 January, 2017
Brawn returns to F1 in senior Liberty role - 24 January, 2017
Ecclestone removed as F1's CEO - 24 January, 2017
Pitlane start for Sainz Jr
Force India targets points with race pace
Sainz Jr gets the nod for STR drive
Sainz Jr set for Caterham debut?
Sutil targets a top-six finish in Melbourne
Carlos Sainz Jr Max Verstappen Toro Rosso
« GP2: 2015 Abu Dhabi Preview
V8s: Super Black Racing confirms Pither »


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Q: How to instantiate groovy.sql.Sql with parameters from spring datasource setup from test application.yml in a SpringBoot application test context? I have a SpringBoot maven project, and it has a repository related jar sub-module, which stores the DB related executions, the repository classes with JdbcTemplate and etc.
I want to test the database with Spock Groovy.
This is my pom.xml:
...

<dependencies>
    <dependency>
        <groupId>org.springframework.boot</groupId>
        <artifactId>spring-boot-starter-web</artifactId>
        <exclusions>
            <exclusion>
                <groupId>org.springframework.boot</groupId>
                <artifactId>spring-boot-starter-logging</artifactId>
            </exclusion>
        </exclusions>
    </dependency>
    <dependency>
        <groupId>org.springframework.boot</groupId>
        <artifactId>spring-boot-starter-jdbc</artifactId>
    </dependency>
    <dependency>
        <groupId>org.springframework.boot</groupId>
        <artifactId>spring-boot-starter-test</artifactId>
        <scope>test</scope>
    </dependency>
    <dependency>
        <groupId>org.springframework.boot</groupId>
        <artifactId>spring-boot-configuration-processor</artifactId>
        <optional>true</optional>
    </dependency>

    <dependency>
        <groupId>org.springframework</groupId>
        <artifactId>spring-tx</artifactId>
    </dependency>

    <dependency>
        <groupId>com.microsoft.sqlserver</groupId>
        <artifactId>mssql-jdbc</artifactId>
    </dependency>

    <!-- Spock Dependencies -->
    <dependency>
        <groupId>org.spockframework</groupId>
        <artifactId>spock-spring</artifactId>
        <scope>test</scope>
    </dependency>
    <!-- enables mocking of classes (in addition to interfaces) -->
    <dependency>
        <groupId>cglib</groupId>
        <artifactId>cglib-nodep</artifactId>
        <scope>test</scope>
    </dependency>
    <!-- enables mocking of classes without default constructor (together with CGLIB) -->
    <dependency>
        <groupId>org.objenesis</groupId>
        <artifactId>objenesis</artifactId>
        <scope>test</scope>
    </dependency>
    <dependency>
        <groupId>org.codehaus.groovy.modules.http-builder</groupId>
        <artifactId>http-builder</artifactId>
        <scope>test</scope>
    </dependency>
    <!-- Spock End -->
</dependencies>

<build>
    <finalName>${project.artifactId}</finalName>
    <plugins>
        <plugin>
            <groupId>org.apache.maven.plugins</groupId>
            <artifactId>maven-surefire-plugin</artifactId>
            <configuration>
                <includes>
                    <include>**/*Spec.*</include>
                    <include>**/*Test.*</include>
                </includes>
            </configuration>
        </plugin>
        <plugin>
            <groupId>org.codehaus.gmavenplus</groupId>
            <artifactId>gmavenplus-plugin</artifactId>
            <version>1.5</version>
            <executions>
                <execution>
                    <goals>
                        <goal>compile</goal>
                        <goal>testCompile</goal>
                    </goals>
                </execution>
            </executions>
        </plugin>
        <plugin>
            <groupId>org.apache.maven.plugins</groupId>
            <artifactId>maven-jar-plugin</artifactId>
            <executions>
                <execution>
                    <goals>
                        <goal>test-jar</goal>
                    </goals>
                </execution>
            </executions>
        </plugin>
    </plugins>
</build>

...

This is the application.yml from test/resources:
spring:
  datasource:
    platform: sqlserver
    driver-class-name: com.microsoft.sqlserver.jdbc.SQLServerDriver
    url: jdbc:sqlserver://localhost;databaseName=mydatabase;integratedSecurity=true

server:
  address: 127.0.0.1
  port: 9000

This is the application config in main/java/mypackage:
@Configuration
@ComponentScan
@EnableAutoConfiguration
public class RepositoryConfig {

}

This is the groovy test spec which should setup the groovy.sql.Sql:
@SpringBootTest(classes = RepositoryConfig.class, webEnvironment = WebEnvironment.MOCK)
@Configuration
@EnableConfigurationProperties
@Transactional
class BaseSpringBootTestSpec extends Specification {

    String url
    String username
    String password
    String driverClassName

    protected groovy.sql.Sql sql

    def setup() {
        sql = groovy.sql.Sql.newInstance(url, username, password, driverClassName)
    }

    def cleanup() {
        sql.close()
    }

}

But here I get NullPointerException because the properties are all null (url, driverClassName, etc).
And I don't know how to get them from yml properties in text context.
Any idea? Thanks.
Blockquote

A: You're never telling Spring to actually inject those values. Adding @Value annotations to your fields should fix your problem. E.g.:
@Value("#{spring.datasource.url}")
String url

A: Probably easiest to use theSql.newInstance(...) constructor, passing along a DataSource automatically injected from your Spring Boot config.
@Autowired
DataSource apexDatasoure

...And later when you want to perform some Sql:

Sql.newInstance(apexDatasoure).with { db ->
   ...
}

redpajama_set_name: RedPajamaStackExchange


From the first moment I saw Koreatown: A Cookbook it spoke to me. Not because I'm Korean or speak Korean, but because I live in Los Angeles – home to one of the largest, most vibrant Koreatowns in the United States. Our Koreatown occupies a sprawling swath of amorphous turf between Hollywood and DTLA. It's one of the most interesting neighborhoods in the city. This is no Chinatown in the San Francisco tradition. It's K-town. There are few concessions to the uninitiated. It can seem as foreign as Seoul itself. You'll find herbalists, karaoke bars, grocery stores, even churches. The sheer size and vitality of the metro scene is astonishing – so are the restaurants.
One thing you'll notice about this city within a city is just how dense it is with eateries. Some serving famous Korean dishes: Bulgogi, BBQ and Soontofu. I'm comfortable ordering these well-traveled favorites. However, for people like me who don't speak Korean, the more obscure dishes can present some challenges. You see, language isn't the only obstacle to eating well in K-town. First you must figure out where to go for which type of food. When Koreans eat out, they often first decide what dish they're in the mood for then choose a restaurant that specializes in that dish.
Which can be intimidating for folks like me.
I consider myself an adventurous eater and there's nothing I enjoy more than trying new restaurants, exotic cuisines and unfamiliar flavors. With Koreatown so close to my home, it's easy for me to make semi-regular visits. Yet I balk sometimes because I feel some slight trepidation when faced with an untranslated menu in a bustling Korean restaurant. I'm sometimes too intimidated to do anything but point at pictures.
Well I'm tired of limiting myself to Korean menus with pictures!
The answer to this dilemma is of course education. As a cook I'm of the strong opinion that the best way to understand a culture is to understand its cooking – making Koreatown: A Cookbook more than a collection of recipes. For me it's a textbook in understanding (and recognizing) the menu items that, until now, have seemed like an unpronounceable collection of odd-looking words.
The book gets going with an explanation of ingredients and tools. Consider it a Korean Cooking 101 syllabus. These straightforward explanations are important for the home cook, but if your goal is to simply develop some confidence on your next trip to Koreatown – you'll appreciate this section too.
Which makes this chapter a delight. I'm a cook that appreciates variety. Banchan makes every meal in Koreatown perfectly customizable (with every single bite). I'll never again have to wonder which banchan goes with which dish. I've thrown those worries out the window (along with the rules).
The book continues with the classic foods you'd expect and may have had some experience with. However, there are plenty of other dishes that seem more challenging. These are the exciting recipes. The recipes that cause me to gleefully flip back and forth to the (much appreciated) glossary in the back. I'll be excited to tackle some of these delicacies as my education continues.
There's also a section of "guest recipes". These are often creative takes on Korean food or Korean cooking styles from chefs whose work is "informed by Asian flavors" in "both traditional and nontraditional ways".
I was sent a review copy of Koreatown: A Cookbook by Deuki Hong and Matt Rodbard. All opinions are my own. Blogging for Books.
Slice the meat into batons about ¼ inch wide. Reserve in a bowl.
Place the meat in a freezer, along with an empty serving bowl, and chill until the meat is firm and just beginning to freeze, about 20 minutes. The thinner you slice the meat, the quicker it will freeze.
While the meat is freezing, make the marinade by combining all the ingredients in a bowl.
Remove the meat from the freezer right before you are going to serve and toss it in the marinade. The meat should still remain very cold, so do not over-toss.
Place the meat in the center of the chilled serving bowl. Garnish with the Asian pear, cucumbers, pine nuts and egg yolk. Season with salt and pepper and serve immediately, mixing the yolk into the meat at the table.
We too, have quite the bustling Korean-town in Toronto but I've not ventured to a restaurant yet for many of the same reasons you haven't. Steak tartare is by far, one of my most favourite beef dishes. I love the traditional French version with the chopped capers or cornichon and grainy mustard but this version also looks intriguing. Sadly, it's not something I would make at home because I am the only one who eats it. I do like a coarser chop than a grind or a fine chop. The cookbook looks interesting too and a great intro into Korean Cuisine.
Raw, cooked, or pickled, I love meat any what you can slice it. And the book looks great, too. I grew up with a Korean family in the 'hood and used to hang out all the time just to see what their cook was making.
I'm not a fan of raw meat, but that cookbook looks interesting.
It has to be a delight to live in a city where so many ethnic restaurants are made available to try. I've not had any Korean food and the book sounds like a great introduction.
This sounds amazing, Greg! Sounds like this would also be a great way to use up the chain from a beef tenderloin, too.
The Germans love their Gehacktes ( ground pork) on a roll with onions. That's raw pork. I am not a fan of raw meets , pork or beef.
With the pine nuts and raw egg, this one looks a lot like what Armenians call chi-kufte.
I don't eat raw beef, but I'll bet it's SO delicious!


text:
Purdue Pharma L.P. v. Varam, Inc.
Patent-in-suit not invalid, particularly in view of the same or similar arguments being raised, and rejected, in previous actions.
Case Name: Purdue Pharma L.P. v. Varam, Inc., Civ. No. 04 Md. 1603 (SHS), 2013 U.S. Dist. LEXIS 58592 (S.D.N.Y. Apr. 15, 2013) (Stein, J.)
Drug Product and Patent(s)-in-Suit: OxyContin® (oxycodone); U.S. Patent No. 5,508,042 ("the '042 patent")
Nature of the Case and Issue(s) Presented: Varam brought summary-judgment motions of invalidity and noninfringement of the '042 patent. Varam relied principally on the '598 patent, which claimed a particular formulation to be used for controlled-release oral administration of drugs, not just oxycodone. But twice before, the court had issued opinions concerning the '042 patent. On one occasion, Purdue moved for a preliminary injunction and the court found that (i) it was likely to succeed on the merits of its infringement claim and (ii) the '042 patent was not anticipated by the '598 patent. In a separate action, three years after the preliminary injunction hearing referenced above, the court held a trial and found the patents (including the '042 patent) infringed, but invalid due to Purdue's inequitable conduct during prosecution. The Federal Circuit affirmed the infringement ruling, and ultimately vacated the inequitable conduct finding. The court denied Varam's instant motion.
Why Purdue Prevailed: The district court and Federal Circuit have already construed the two claims of the '042 patent at length. Varam argued that the court should reevaluate its conclusion that the preambles do not limit the '042 patent's claims. But the court found that the Federal Circuit explicitly held that the prosecution history did not limit the substantive terms of the asserted claims, and therefore would not "smuggle" that language back into the claims. Next, Varam argued that the '598 patent anticipates the '042 patent because "all prior art controlled release oxycodone-containing tablets that have been taught by the '598 patent and which were analyzed for their clinical properties have been found to inherently anticipate the '042 patent claims." Varam's argument ignores the first court decision referenced above when Purdue sought a preliminary injunction against Boehringer. The court held that Varam presented considerably less evidence than the court considered during the Boehringer proceeding, yet Varam seeks a more favorable result for itself. Because the court already considered this evidence once before, it found that a material question of fact existed as to whether the in vitro teachings of the '598 patent anticipate the in vivo limitations of the '042 claims.
By relying on the same prior art in support of its obvious defense, the '598 patent, the court found the genuine issues of material fact remain as to the scope and content of the '598 patent's teachings.
The court equally disposed of Varam's contention that the '042 patent fails to satisfy the written description requirement. Example 18 of the '042 patent describes an in vivo study of a 10 mg controlled-release oxycodone tablet that produced plasma concentrations and time ranges that fall within the scope of the asserted claims. In addition, the '042 patent details repeated dose studies that conform to the claimed invention. That alone precluded the court from granting Varam's summary-judgment motion for failure to meet the written description requirement.
Finally, Varam argued that the asserted claims are invalid on double-patenting grounds. Varam relied on three patents in support of its argument. The first patent claims in vitro characteristics of oxycodone. The court cannot evaluate whether in vitro teachings make in vivo limitations in the '042 patent obvious, therefore, Varam has not met its clear and convincing burden as to its double-patenting argument in this first instance. The second patent covers inventions that are the different from the '042 patent—as evidenced by the restriction requirement raised by the USPTO, thus, there is no same-invention type double patenting. Finally, the third patent issued almost a year after the '042 patent was approved. Because Varam cannot turn back time to find a way to use the third patent to invalidate the earlier-applied-for and earlier-issued '042 patent, there cannot be double patenting.
GENERICally Speaking Summer 2013
Jeffrey Alan Hovden
Oren D. Langer
Ryan M. Schultz
Allergan Sales, LLC v. Sandoz, Inc
GENERICally Speaking Fall 2019
Amgen Inc. v. Amneal Pharms. LLC
ANDA Approvals
ANDA Litigation Settlements
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Jake Holdreith and Ronald Schutz Named 2018 "Life Sciences Stars" by LMG Life Sciences
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Robins Kaplan LLP Named a Recommended Firm for Hatch-Waxman by LMG Life Sciences
Federal Circuit Upholds Ruling in Favor of Novel Laboratories, Inc. in Sleep Aid Patent Case
LMG Life Sciences Names Robins Kaplan Partner Jake Holdreith 'General Patent Litigator of the Year'

redpajama_set_name: RedPajamaCommonCrawl


text:
Prevalence, Risk Factors, and Antimicrobial…
Prevalence, Risk Factors, and Antimicrobial Resistance Profiles of Thermophilic Campylobacter Species in Humans and Animals in Sub-Saharan Africa: A Systematic Review
Noel Gahamanyi, Leonard E. G. Mboera, Mecky I. Matee, Dieudonné Mutangana, and Erick V. G. Komba
Thermophilic Campylobacter species are clinically important aetiologies of gastroenteritis in humans throughout the world. The colonization of different animal reservoirs by Campylobacter poses an important risk for humans through shedding of the pathogen in livestock waste and contamination of water sources, environment, and food. A review of published articles was conducted to obtain information on the prevalence and antimicrobial resistance (AMR) profiles of thermophilic Campylobacter species in humans and animals in sub-Saharan Africa (SSA). Electronic databases, namely, PubMed, Google Scholar, Research4life-HINARI Health, and Researchgate.net, were searched using the following search terms "thermophilic Campylobacter," "Campylobacter jejuni," "Campylobacter coli," "diarrhea/diarrhoea," "antimicrobial resistance," "antibiotic resistance," "humans," "animals," "Sub-Saharan Africa," and "a specific country name." Initially, a total of 614 articles were identified, and the lists of references were screened in which 22 more articles were identified. After screening, 33 articles on humans and 34 on animals and animal products were included in this review. In humans, Nigeria reported the highest prevalence (62.7%), followed by Malawi (21%) and South Africa (20.3%). For Campylobacter infections in under-five children, Kenya reported 16.4%, followed by Rwanda (15.5%) and Ethiopia (14.5%). The country-level mean prevalence in all ages and under-five children was 18.6% and 9.4%, respectively. The prevalence ranged from 1.7%–62.7% in humans and 1.2%–80% in animals. The most reported species were C. jejuni and C. coli. The AMR to commonly used antimicrobials ranged from 0–100% in both humans and animals. Poultry consumption and drinking surface water were the main risk factors for campylobacteriosis. The present review provides evidence of thermophilic Campylobacter occurrence in humans and animals and high levels of AMR in SSA, emphasizing the need for strengthening both national and regional multisectoral antimicrobial resistance standard surveillance protocols to curb both the campylobacteriosis burden and increase of antimicrobial resistance in the region.
Seroprevalence and associated risk factors of Dengue fever in Kassala state, eastern Sudan
Knowledge, attitudes and practices regarding antimicrobial use and resistance among communities of Ilala, Kilosa and Kibaha districts of Tanzania
Persistent domestic circulation of African swine fever virus in Tanzania, 2015–2017
Antimicrobial use and resistance in food-producing animals and the environment: an African perspective
Seroprevalence of human Brucellosis and associated risk factors among high risk occupations in Mbeya Region of Tanzania


text:
Visiting Europe? Get Your Measles Shot
Record-High Number of Cases in France, Italy, Greece, Other Locations
Measles cases throughout Europe are at a record-high level, and U.S. travelers should make sure they are up to date with measles immunization, and other recommended vaccines, say the Centers for Disease Control and Prevention.
As of March 28, 2019, the World Health Organization European Region reported a total of 83,540 measles cases and 74 related deaths for 2018, the highest incidence since the 1990s.
France, Italy, and Greece, which are favorite destinations for U.S. travelers, have particularly high numbers of cases, as do Georgia, Russia, Serbia, and Ukraine, which has the highest number of cases. Italy is the 10th most popular destination for American visitors and approximately 2.5 million Americans traveled to the country in 2015.
Officials are concerned because many people do not consider Europe as a place with infectious-disease risk. But the large number of measles infections in the region underscore the need for people to consult with their doctor before traveling.
Also, health care providers should be rigorous in checking for symptoms of measles among people who have recently been abroad. As measles is highly contagious, unvaccinated/under-vaccinated travelers to Europe are susceptible to infection; if travelers return home sick, they also increase the risk of infection for anyone they come across once they are back in the U.S.
Although measles was eliminated in the U.S. in 2000, that status is under threat. As of June 13, the number of domestic measles cases has reached 1,044, which is the highest count since 1992.
In Europe, measles remains endemic in Belgium, Bosnia and Herzegovina, France, Georgia, Germany, Italy, Romania, the Russian Federation, Serbia, and Ukraine.
A 2017 study revealed that one-third of U.S. travelers to Europe visited the region without being fully vaccinated against measles.
Source: MDedge, June 17, 2019
Vaccine Market Overview & Potential Growth Opportunities, 2011-2022 | Key Players Analyzed: Johnson & Johnson, Merck, Pfizer, Sanofi, GlaxoSmithKline, & Bavarian Nordic | Radiant Insights, Inc.
How much does the world trust medical experts and vaccines?
Antibiotic Market Analysis - New Opportunities Explored, High CAGR & ROI Anticipated Till 2028: Radiant Insights, Inc.
Insulin Market Report Puts Limelight on Historical Development, Current Market Scenarios and Situations & Future Outlook by 2022: Radiant Insights, Inc.
CDC Report: Measles Cases in U.S. Reach 20-Year High
First-Ever State Regulation on Sepsis Tied to Lower Death Rates
NY Hospitals Required to Implement Protocols in Suspected Cases
Unlocking Cancer's Chemo-Resistance
Presence of BOK Protein Key for Positive Treatment Response
First Contrast Agent for Cardiac MRI in Cases of Known/Suspected Heart Disease
Gadavist® Injection Use Enables Fast Assessment
Digital Inhaler Approved for Asthma Treatment
Patient Access to Inhaler Use Data Could Improve Asthma Management
Common Cold Virus Completely Eliminates Bladder Cancer in Patient
Attacks Cancerous Cells, Leaves Healthy Tissues Alone
Triple-Combination Therapy Significantly Improves Colorectal Cancer Outcomes
Overall Survival 4.3 Months' vs. 1.5 Months for Traditional Regimens
Xembify Approved to Treat Chronic Immune System Disorders
Primary Immunodeficiencies Affect 250,000 People in U.S.
FDA Approves New Treatment for Refractory Multiple Myeloma
More Than 25% of Patients Responded to Xpovio/Dexamethasone Combo
Bacterium Limits Cardiovascular Risks of 1 in 2 People
Moderates Pre-diabetes Progression, Reduces Cholesterol Levels


About 132 thousand cases of melanoma (more severe type of skin cancer) were registered in 2014 according to the World Health Organization. This type of cancer significantly affects the quality of life of individuals. Caffeine has shown potential inhibitory effect against epithelial cancer. In this study, it was proposed to obtain new caffeine-based molecules with potential epithelial anticancer activity. For this, a training set of 21 molecules was used for pharmacophore perception procedures. Multiple linear regression analyses were used to propose mono-, bi-, tri-, and tetra-parametric models applied in the prediction of the activity. The generated pharmacophore was used to select 350 molecules available at the ZINCpharmer server, followed by reduction to 24 molecules, after selection using the Tanimoto index, yielding 10 molecules after final selection by predicted activity values > 1.5229. These ten molecules had better pharmacokinetic properties than the other ones used as reference and within the clinically significant limits. Only two molecules show minor hits of toxicity and were submitted to molecular docking procedures, showing BFE (binding free energy) values lower than the reference values. Statistical analyses indicated strong negative correlations between BFE and pharmacophoric properties (high influence on BFE lowering) and practically null correlation between BFE and BBB. The two most promising molecules can be indicated as candidates for further in vitro and in vivo analyzes.
Keywords: Epithelial cancer, caffeine, Chk1, Molecular modeling, multiple linear regression, Pharmacokinetic and toxicological properties.
Keywords:Epithelial cancer, caffeine, Chk1, Molecular modeling, multiple linear regression, Pharmacokinetic and toxicological properties.
Abstract:About 132 thousand cases of melanoma (more severe type of skin cancer) were registered in 2014 according to the World Health Organization. This type of cancer significantly affects the quality of life of individuals. Caffeine has shown potential inhibitory effect against epithelial cancer. In this study, it was proposed to obtain new caffeine-based molecules with potential epithelial anticancer activity. For this, a training set of 21 molecules was used for pharmacophore perception procedures. Multiple linear regression analyses were used to propose mono-, bi-, tri-, and tetra-parametric models applied in the prediction of the activity. The generated pharmacophore was used to select 350 molecules available at the ZINCpharmer server, followed by reduction to 24 molecules, after selection using the Tanimoto index, yielding 10 molecules after final selection by predicted activity values > 1.5229. These ten molecules had better pharmacokinetic properties than the other ones used as reference and within the clinically significant limits. Only two molecules show minor hits of toxicity and were submitted to molecular docking procedures, showing BFE (binding free energy) values lower than the reference values. Statistical analyses indicated strong negative correlations between BFE and pharmacophoric properties (high influence on BFE lowering) and practically null correlation between BFE and BBB. The two most promising molecules can be indicated as candidates for further in vitro and in vivo analyzes.


text:
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Area scoreboard: Results for Wednesday, Oct. 3, 2018
Area results Wednesday
College volleyball
MIAC:
St. Benedict 3, Carleton College 0 (25-8, 25-6, 25-22)
Central Lakes:
ROCORI 4, Sauk Rapids 1
Sauk Rapids 4, ROCORI 0
Adapted soccer
Nonconference:
St. Cloud Area 7, Columbia Heights 1
Litchfield invitational with Holdingford, Eden Valley-Watkins, Sauk Rapids, Albany and St. Cloud Christian, 4 p.m.
Perham invitational with Little Falls, 4 p.m.
BOLD invitational with Paynesville, 4:15 p.m.
Girls swimming and diving
Central Lakes — Alexandria at ROCORI, 6 p.m.; Brainerd at Sartell, 6 p.m.; Sauk Rapids at St. Cloud Tech, 6 p.m.; St. Cloud Apollo at Willmar, 6 p.m.
Granite Ridge — Albany at Mora, 6 p.m.; St. Cloud Cathedral at Becker, 6 p.m.; Milaca at Foley, 6 p.m.
Nonconference — Little Falls at Sauk Centre, 6 p.m.
Central Lakes — St. Cloud Apollo at Sauk Rapids, 5 p.m.; St. Cloud Tech at Willmar, 5 p.m.; Sartell at ROCORI, 5:30 p.m.
Granite Ridge — Zimmerman at St. Cloud Cathedral, 5 p.m.; Little Falls at Becker, 7 p.m.
Nonconference — St. John's Prep at Melrose, 5 p.m.
Central Lakes — ROCORI at Sartell, 5 p.m.; Willmar at St. Cloud Tech, 7 p.m. at SCSU; Sauk Rapids at St. Cloud Apollo, 7 p.m.
Granite Ridge — Becker at Little Falls, 5 p.m.
Nonconference — St. Cloud Cathedral at Minnewaska, 5 p.m.; Melrose at St. John's Prep, 5 p.m. at SJU
Central Lakes — Sauk Rapids at Fergus Falls, 7 p.m.; Sartell at St. Cloud Apollo, 7 p.m.; ROCORI at St. Cloud Tech, 7 p.m.
Granite Ridge — St. Cloud Cathedral at Little Falls, 7 p.m.; Becker at Mora, 7 p.m.; Albany at Foley, 7:15 p.m.; Milaca at Zimmerman, 7:15 p.m.
Central Minnesota — Holdingford at Belgrade-Brooten-Elrosa, 7:15 p.m.; Kimball at Maple Lake, 7:15 p.m.; Eden Valley-Watkins at Paynesville, 7:15 p.m.; Howard Lake-Waverly-Winsted at Pierz, 7:15 p.m.
West Central — BOLD at Melrose, 6 p.m.


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Jet Aire Has Recently Appointed Simon Lawton to Their Board
Jet Aire, the Leeds based company has recently appointed Simon Lawton to their board as a non-executive chairman. Simon has been working with the drainage contractors since 2014 on a number of different ad hoc projects. Over the course of the past six months, Simon Lawton has been working with the directors and the senior management team in order to lay foundations for the next stage of the company's growth. The company is looking to expand their presence in the provision of professional drainage solutions to the company's commercial, industrial and domestic clients.
Simon Lawton has a great track record as a finance director for a number of rapidly expanding entrepreneurial businesses. Most notably, Simon worked for Tribal Group Plc and managed to help the company grow from a start-up company to a business with sales of over £250 million over the course of 10 years. Simon is a founder trustee for the Tribal Group Foundation which works to raise money and fund different health and education projects in Africa, India and Nepal. Simon spent two year working on a variety of different investment projects in Sub-Saharan Africa. These investment projects include a 5-star island tourist resort which is located in the Indian Ocean near Mozambique.
In 2013, Simon worked to help co-launched a new start up support services business which is called Benula Capital Limited. This support services company works within the recruitment and HR market and currently holds a number of equity stakes in several different companies around the UK and Internationally. Benula looks to help companies carry out an accelerated growth strategy through strategic financial and development advice for owners and managers.
As part of Jet Aire, Simon will be offering the Leeds based drainage contractor advice on the best ways to push the business forward. Jet Aire has been benefitting from a sustained period of growth and plans to extend further over the next five years.
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Dragon Ball: The Road to Film 20 – Part I
December 15, 2018 Deshawn Vasquez 7 comments
Toei Animation seems to be pooling every available resource to make Dragon Ball Super: Broly the most action-packed, visually stunning film in the franchise to date, marking the 20th Dragon Ball film. I've been foaming at the mouth over the project since it was first announced, and it seems as good a time as any to look at the movies and TV specials leading up to this point. I will be covering every one to date, including two OVAs. I will however, be excluding the Toriko and One Piece crossover special as it's focus is split between two other franchises. I will also be covering each in release order rather than where it may or may not fit arc-wise. For consistency's sake, I'll also be using dub terminology and names across the board, despite knowing the franchise in and out in both languages. These are less reviews and more quick reflections on what we've had up to this point.
Curse of the Blood Rubies
(Legend of Shenlong)
Original release: December 20, 1986
Now, the first three films are abridged reimaginings with changes made to conform to the new medium. They were made as more or less an outlet for newcomers to get a streamlined version of the story in order to boost interest in
the series. In this case, this is a retelling of first arc with a few changes. A mountain boy named Goku lives alone in the wilderness and a sixteen year old girl named Bulma runs into him while searching for Dragon Balls. Same old, same old. What does change is some of the circumstances. Pilaf has been switched out for Gurumes, a king cursed with an unending hunger, laying waste throughout the land with a clear stand-in for the Red Ribbon Army at his disposal, who are searching for the Dragon Balls as well. Because this is meant to bring in newcomers to the series, the film spends half of its runtime reestablishing the premise and cast. Bulma hitting Goku with her car, Yamcha and Puar starting out as bandits and quickly becoming allies, and the altercations at the castle. It's really just the first 13 episodes of the anime with a bit of the Red Ribbon Army arc sprinkled in.
While the film invokes pure Dragon Ball, it's not going to do much for established fans. That being said, as an introduction to the franchise's inception, it's an enticing one-and-done with crisp animation. Depending on how you feel about the franchise in any given language however, you may not be a fan of the 2010 re-dub, which utilizes Colleen Clinkenbeard as Goku (replacing Stephanie Nadolny from the series) and Monica Rial as Bulma (replacing Tiffany Vollmer) as a precursor to the Kai dub which was in production at the time. I know Kai is divisive among fans, so it's worth noting.
Sleeping Princess in Devil's Castle
Original release: July 18, 1987
In proper sequel form, we follow the next piece of source material to cherry pick. In this case, Goku finds Master
Roshi after their first meeting and begs for his tutelage. The old lech is hesitant about taking on a student, though. A young martial artist named Krillin then arrives at Kame House with the same intention, and acts a foil to Goku from that point. Roshi recounts the legend of the titular princess, held captive in the Devil's Hand mountains by a vampiric count named Lucifer. Roshi poses a challenge to the boys: whoever can save the princess is worthy of his training.
And so they travel to the mountains and battle their way through monsters of the underworld in order to save what ends up being a clever inserted character from the series proper. Ironically, this is the most original of the three films, as it changes quite a bit, so it should be the freshest for both newcomers and longtime fans. Sadly, no. This is not only the weakest of the three here, but one of the weakest of the franchise.
In spite of its more original narrative, the entire production is drab, the enemies are uninspired and the fights are poorly animated. It was the first film to feel distinctly unfitting for the franchise, something that wouldn't end here. I appreciate it for separating itself from the source a little more, making it a little more memorable than the other two in certain places, but it's a chore to get through, despite most of the films only having about a 50 minute runtime at best.
Mystical Adventure
Original release: July 9, 1988
Retread: Part III. Except it's good this time. This is a hybrid between the 21st and 22nd World Martial Arts Tournaments in the series, with more direct tie-ins to the Red Ribbon Army arc, both to it's advantage and detriment.
Having trained for some time, Roshi signs Goku and Krillin up for the World Martial Arts Tournament, held in the country of Mifan. The emperor of Mifan is a young boy named Chiaotzu, who is searching for his lost doll "Ran Ran", going so far as to send his subordinates searching for the Dragon Balls in order to find it. This is a ruse from the Minister, who's planning to assassinate the emperor and take over the country. Of course, Goku just somehow manages to get involved and what should have been a simple competition gets a lot more complicated. Too complicated, in fact.
It's an interesting take on the arcs, particularly since one of my personal gripes with the Red Ribbon Army arc is its
length. However, the project undermines itself in the third act by trying to fit Korin's Tower, Mercenary Tao and Penguin Village in what is already a movie filled to the brim. Combining the two tournament arcs makes sense, even sprinkling aspects of one of the franchise's longer arcs is risky but it works for most of the movie. Waiting until the third act to then retroactively fit three arcs into one film is messy.
Had they kept the focus straight, this would be one of the best films, and a welcome adaptation of the aforementioned plotlines, but it gets sloppy by the end. There's a lot of character here, though. The animation is a notable improvement from the last and there's a genuine sense of scale and tension this time. The positives are so great that it's actually better than Curse of the Blood Rubies. But, there are better to come.
(Return my Gohan!!)
Original release date: July 15, 1989
It's fitting to talk about this alongside the previous three, as despite this being the first Z film, it still retains the character of the series predecessor. This film was produced in that perfect window where the franchise as a whole was transitioning to a more battle-centric focus with a lean towards sci-fi, but still maintained the mysticism and adventure (or mystical adventure, if you will). It's a perfect balance. This was also before fights tended to rely on spectacle, so the choreography is more fluid and traditional, Goku still utilizing the Power Pole in addition to astonishing hand-to-hand combat before they used fast-paced, blurry clashes as a crutch.
Garlic Jr. is the son of… well… Garlic. Garlic fought with Kami for rank of Guardian of the Earth (God in the sub), and
their master sealed his power away for his evil intentions and eventual revolt. Garlic Jr. continues his father's ambition for conquest by gathering the Dragon Balls, kidnapping Gohan in the process due to the Four-Star Ball on his hat. In an interesting turn of events, Garlic Jr. actually successfully wishes for immortality (unlike King Piccolo who wished for his youth back) just before Goku and Kami arrive to stop him.
I love that Garlic Jr. is a villain rooted in the series lore, and his design not only in literal appearance but purpose in the story is genuine and cunning. It's a shame that his ultimate hubris by the end as well as the much hated Garlic Jr. mini-arc (saga if you're a dubbie) later on undercuts him. Although in the former's case, they had to find a way to get around the immortality somehow. Not only was this the most well-animated product for the franchise at the time, but it actually used transformation as a plot device well before the canon dipped its toe in that pond. Same goes for a villain successfully gaining immortality via the Dragon Balls. Sorry, [insert Dragon Ball Super villain here]. I love this movie, and it's a damn shame we're about to hit a rough patch.
tagged with Akira Toriyama, broly, curse of the blood rubies, dead zone, dragon ball, fuji tv, funimation, masako nozawa, Movies, mystical adventure, retrospective, sean schemmel, shueisha, sleeping princess in devil's castle, specials, super, the road to film 20, toei animation
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Category: Rings. Tags: Amethyst, Blue, Citrine, Garnet, Orange, Purple, Red, Ring, Sterling Silver, Yellow, Zircon.
Give your Mom a Sterling Silver ring containing all the Birthstones of you and your siblings. The ring can be customized for 3 to 7 gems. Here we've used a blue Zircon, Garnet, Citrine and Amethyst. This particular ring is priced at $ 84. Other 3.5mm gemstones are available at various prices.
If you like the setting, you could alternatively use the same gemstone in all 3 to 7 gem positions.
Ring finger size made to order.


It is the holiest day of the year in Judaism.
Its central themes are atonement and repentance.
Jewish people traditionally observe this holy day with an approximate 25-hour period of fasting and intensive prayer, often spending most of the day in synagogue services.


text:
'''
	This is where we want to go through and check for any updates to the remote data sets that we're using.
	If a remote data set has been updated, we will fetch it and populate the updates to our database.
'''
import os
import urllib2
from datetime import datetime

from HTMLParser import HTMLParser
from sqlalchemy import create_engine
from farmsList.settings import ProdConfig, DevConfig
from updaters import WestSacParcelUpdater, WestSacWaterUpdater, SoilUpdater, FoodDesertUpdater

# establish connection with the database we want to be using
if os.environ.get("FARMSLIST_ENV") == 'prod':
	engine = create_engine(ProdConfig().SQLALCHEMY_DATABASE_URI)
else:
	engine = create_engine(DevConfig().SQLALCHEMY_DATABASE_URI)
connection = engine.connect()

# create a subclass and override the handler methods
class WestSacUpdateHTMLParser(HTMLParser):
	foundUpdateTag = False
	foundUpdateInstant = False
	updateInstant = datetime.min

	def handle_starttag(self, tag, attrs):
		if ('class', 'aboutUpdateDate') in attrs:
			self.foundUpdateTag = True
		elif self.foundUpdateTag and not self.foundUpdateInstant:
			self.foundUpdateInstant = True
			for attribute in attrs:
				key, value = attribute
				if (key == 'data-rawdatetime'):
					self.updateInstant = datetime.fromtimestamp(int(value))

# create a subclass and override the handler methods
class USDAEconomicResearchServiceParcer(HTMLParser):
	foundUpdateTag = False
	foundUpdateInstant = False
	dataBuffer = ''
	updateInstant = datetime.min

	def handle_starttag(self, tag, attrs):
		if ('id', 'UpdateContact') in attrs:
			self.foundUpdateTag = True

	def handle_endtag(self, tag):
		if tag == 'p' and self.foundUpdateTag and not self.foundUpdateInstant:
			self.foundUpdateInstant = True
			timeString = self.dataBuffer.strip()
			self.updateInstant = datetime.strptime(timeString, '%A, %B %d, %Y')

	def handle_data(self, data):
		if self.foundUpdateTag and not self.foundUpdateInstant:
			self.dataBuffer = data

# create a subclass and override the handler methods
class UCDavisSoilsHTMLParcer(HTMLParser):
	soilRegionCode = ''
	foundYoloSoil = False
	foundUpdateInstant = False
	updateInstant = datetime.min

	def handle_data(self, data):
		if data == self.soilRegionCode:
			self.foundYoloSoil = True
		elif self.foundYoloSoil and not self.foundUpdateInstant and data.strip():
			self.updateInstant = datetime.strptime(data, '%Y-%m-%d')
			self.foundUpdateInstant = True

	def __init__(self, code):
		self.soilRegionCode = code
		HTMLParser.__init__(self)

# for each dataset in the database, we need some special code to check for updates (parcer), and to run new updates when needed (updater)
# this maps the dataset named in the database to a give updater and parser for maintaining the data in our database
def getToolsForDataset(name):
    return {
        'elDoradoSoil': (UCDavisSoilsHTMLParcer('ca624'), SoilUpdater('ElDorado')),  # ca724,ca693 are also technically required for el dorado county soil mapping
        'foodDesertSACOG': (USDAEconomicResearchServiceParcer(), FoodDesertUpdater()),
        'placerSoil': (UCDavisSoilsHTMLParcer('ca719'), SoilUpdater('Placer')),
        'sacramentoSoil': (UCDavisSoilsHTMLParcer('ca067'), SoilUpdater('Sacramento')),
        'sutterSoil': (UCDavisSoilsHTMLParcer('ca101'), SoilUpdater('Sutter')),
        'westSacParcels': (WestSacUpdateHTMLParser(), WestSacParcelUpdater()),
        'westSacWater': (WestSacUpdateHTMLParser(), WestSacWaterUpdater()),
        'yoloSoil': (UCDavisSoilsHTMLParcer('ca113'), SoilUpdater('Yolo')),
        'yubaSoil': (UCDavisSoilsHTMLParcer('ca618'), SoilUpdater('Yuba'))
    }[name]

def every_night_at_1am():
	print 'Starting the 1am job.'
	# Important to note that the order of the updates in the database matters
	# For example, the soil of the imported parcels is based on soil data already being present
	remoteDatasets = connection.execute("SELECT * FROM remote_datasets ORDER BY id")
	for dataset in remoteDatasets:
		name = dataset.name
		print 'Checking for update to dataset: ' + name
		responseHtml = urllib2.urlopen(dataset.url).read()
		parser, updater = getToolsForDataset(name)
		parser.feed(responseHtml)
		updateInstant = parser.updateInstant.strftime('%Y-%m-%d %H:%M:%S')
		print 'Last Updated Locally: ' + dataset.lastUpdatedLocally.strftime('%Y-%m-%d %H:%M:%S')
		print 'Last Updated Remotely: ' + updateInstant
		if parser.updateInstant > dataset.lastUpdatedLocally:
			print 'Updating dataset: ' + name
			updater.update()
			print 'Finished updating dataset: ' + name
			connection.execute("UPDATE remote_datasets SET \"lastUpdatedLocally\"='{}' WHERE id={}".format(updateInstant, dataset.id))
		else:
			print 'No update required for dataset: ' + name
	print 'Finished the 1am job.'

redpajama_set_name: RedPajamaGithub


A small battle just ended in the airways of Canadian broadcast television. It was around a form of ad blocking.
You see, when Canadian TV simulcasts an American program the US-based ads get swapped-out for Canadian ads. It's a process call simultaneous substitution, or simsub.
Think about it. It's a form of ad blocking that's being REMOVED.
Why? Because those US Super Bowl ads are relevant while we watch the big game. We're in an entertainment frame of mind. We perceive those ads as another form of entertainment. They're usually interesting and unique. That makes them relevant to our viewing experience. So bring it on we say!
The matter at hand will be my own concerns, needs and interests. These get stirred by what I'm reading or watching or listening to.
Put all those matters together and show me relevant ads, I say. So when I'm ready to buy, I know where to shop.
Because there will come a time when I'll be ready to shop. I don't deny it. I'm a consumer. Make it easy for me to make my best consumption choice.
Currently, ad-serving systems make educated guesses to serve us relevant ads. For example, Google began with your search keywords. Now they can add your browsing history and even mine your Gmail account. It's all about building a profile of relevancy about you. But it's still just educated guessing.
Relevant ads to me are helpful ads. Educational ads. And I'll be pleased to see ads like that all day long.
But in my opinion, ad blocking is using a sledge hammer to do a tack hammer's job. An ad blocker is a broad statement saying nothing is relevant. Really? Are you sure?
I don't need everything blocked. Just don't show me ads that are irrelevant to my concerns, needs or interests.
I'm okay with ads that are specific to my frame-of-mind when I'm currently engaged on a website.
As readers we can all help move the relevancy filter along by participating in AdChoices. If you haven't realized, AdChoices is that little blue triangle icon appearing in the corner of many online ads. Click the little icon and you can explore ways to help improve your relevancy journey.
Even so, you may be left wondering, "How can I remove ads from Firefox (or Chrome, or Edge)?"
That's okay. It's your web browsing experience.
AdChoices only covers participating AdChoices ads. There are other ad services out there not participating. And many of them either fail at relevancy or appear annoyingly as GIFs and intrusive pop-ups.
If you've got a favourite ad blocker that I've missed, please share it below with a comment.
Do you realize that the Internet of Things (IoT) is no longer on the horizon, but literally at our feet now?
The IoT will become a world of 100 billion connected devices. Imagine the massive amounts of data generated. It'll be loaded with insights, but how do you discover them all?
Machine Learning (ML) is the first answer to all the questions you can ask.
Imagine a computer program that re-organizes itself to deal with new data. That's the definition of ML. It belongs inside the computing domain of Artificial Intelligence.
If you're new to computer programming, then ML is where you want to be. You should have lifelong employment opportunities.
The blogger shares ML knowledge and helps you see trends.
It has ML use-cases and tutorials.
It has an active community of followers - look for lots of post comments.
The blogger has an accessible, readable style.
Here are 5 ML blogs you can start with. You'll find brief introductions to ML, including important concepts, applications and challenges.
Have I missed your favourites? Let me know by posting your comment.
"Kevin put together the foundation of my web presence, delivering creditability, reference showcases and an avenue for customer interaction all in one place. He did this with personal dedication to ensure my business got more than I asked for. I'm excited to share my website with potential clients."
"Kevin writes clearly and has a knack for telling stories. He hits a very good tone for his audience. It feels relaxed and friendly."
"If it's worth doing, it's worth doing well!"
COPYRIGHT © 2013-2017 - Kevin Rokosh. All rights reserved world wide. Awesome Inc. theme. Powered by Blogger.


The group informally meet on the second Monday of every month in the Keys in Yarm, 10:30am - 11:30am.
We also meet every Friday 10:30am -11:30am in the Lotus Lounge in Yarm. This is an informal "get together" over a cup of coffee.
We welcome widowers and men who live alone. Loneliness is an awful situation that doesn't have to be. Come along to our group meeting coffee morning and enjoy a cup of tea/coffee in a friendly and welcoming environment. We have all gone through a similar experience but we now value and enjoy each other's company.
As a relatively new group we are open to suggestions for other activities.
As we function under the umbrella of YAW (Yarm association for the widowed) we are invited to their monthly meeting and regular coffee mornings. we are also invited to attend any excursions or events they arrange.


text:
3.38 Pamela DARWIN
Personal Information | Media | Sources | Event Map | All | PDF
Name Pamela DARWIN
Title 3.38
Born 14 Aug 1803 York County, South Carolina, USA [1]
Census 1810 York County, South Carolina, USA [2]
Pamela Darwin (age 7) presumed in household of father, John Darwin
Pamela Darwin (age 17) presumed in household of father, John Darwin
Pamela Darwin (age 27) presumed in household of father, John Darwin (with daughter Elizabeth M. Darwin)
Slave Transaction 22 Nov 1836 York County, South Carolina, USA [5]
"Nan" bequeathed to Pamela Darwin (age 33) in father's Will
Will 22 Nov 1836 York County, South Carolina, USA [6]
Pamela Darwin (age 33) named a beneficiary in her father's Will
Pamela (Darwin) Summerford (age 37) presumed in household of husband, Isaac Summerford
Pamela (Darwin) Summerford (age 47) in household of husband, Isaac Summerford
Died 12 Jan 1880 York County, South Carolina, USA
Buried Sharon, York County, South Carolina, USA
Commentary: DWD 3.38
Originally, I did not show the children of Pamela (Darwin) Summerford on my family chart but next to them I showed Elizabeth M. Darwin (1822-37) and Sarah Ann Darwin (1929-30), whose data was obtained from the tombstone inscriptions at the Darwin Burial Ground in York County, as the children of Peyton Bland Darwin since I was unable to see them fitting into any other family in S. Carolina.
However, I was in error because the 1830 census for S. Carolina indicated that Peyton Bland Darwin had only one child, John Asbury Darwin, at home in 1830 and was therefore unlikely to be the father of Elizabeth. The identity of the parents of Elizabeth and Sarah Ann became revealed when it was noted that the Darwin/Bland bible record showed that they also had two brothers, John and James:
1. Elizabeth M. Darwin	born Aug 27th 1822
2. Sarah Ann Darwin	born Jan 20th 1829
3. John Darwin Jun.	born Feb 18th 1831
4. James Darwin	born April 13th 1833
I have always regarded the Darwin/Bland bible record as a fundamental document in the research of the early Darwin history and have considered its data reliable especially as spaces have been left where the dates were uncertain and presumably were intended to be added at a later date. It can be seen clearly that the above four children cannot be dovetailed into Peyton Bland Darwin's family as there were two contemporary children, both named John Darwin, living in 1831 and I did not see the obvious answer to the parentage until Tim Grana pointed out to me that the list shown above had a remarkable similarity to the list that I had drawn up for the Summerford children, which was constructed from the records shown in Gayle Blankenship's book along with the 1837 Will of John Darwin Senior, that links together Pamela Summerford's daughter, Elizabeth Mourning, with her two brothers, John and James. Acceptance of the Darwin/Bland bible record would imply that all four children were born to Pamela before her marriage to Isaac Summerford as they are all recorded with the Darwin family name and that immediately raises the question as to whether Isaac Summerford was the father of these children.
The Mary Darwin Hope bible record gives a marriage date for Isaac Summerford and Pamela Darwin as January 22, 1822, which would appear to solve all the problems but cannot be correct since the tombstones for Elizabeth and Sarah Ann show that they were buried with the family name of Darwin and not Summerford and would appear to validate the above listing in the Darwin/Bland bible record.
I believe that Gayle Blankenship's records came via the family of the son James and gives a marriage date of 2 May 1825; John Summerford's birth date as ca 1831; and James Thomas Summerford's birth date as 1 May 1833 (which can be seen to disagree by some two weeks from the 13 April 1833 date given in the bible record). Again I would question this marriage date for the same reasons given above and would place Pamela's marriage between April 1833 and 1837, when her father John Darwin made his Will and references her as Pamela Summerford. The marriage dates offered may have been given for the sake of respectability but lacking further information, I am going to accept the implication that Isaac Summerford was the father of all the children.
VFL
Frances Corcoran
Person ID I2708 DARUSA | Descendants of William Darwin
Father John DARWIN, b. 19 Mar 1755, Darwin Home (Hollowing Creek), Louisa County, Virginia, USA , d. 13 Jul 1837, John Darwin Home (Stooping Pines), York County, South Carolina, USA (Age 82 years)
Mother Jane BLAND, b. 02 Jan 1762, Edgefield County, South Carolina, USA , d. 10 Mar 1827, York County, South Carolina, USA (Age 65 years)
Married 11 Mar 1783 [10]
Place unknown for certain, but probably York SC (where John was fighting as a partisan). A number of secondary sources cite Maryland as marriage venue, but primary source for this assertion is unknown.
Family Isaac SUMMERFORD, b. Abt 1796, d. After 1860, Alabama, USA (Age ~ 65 years)
Married York County, South Carolina, USA [11, 12]
1. Elizabeth Mourning DARWIN, b. 27 Aug 1822, York County, South Carolina, USA , d. 22 Oct 1837, York County, South Carolina, USA (Age 15 years)
2. Sarah Ann DARWIN, b. 20 Jan 1829, York County, South Carolina, USA , d. 02 Jan 1830, York County, South Carolina, USA (Age 0 years)
+ 3. John S. Darwin SUMMERFORD, b. 18 Feb 1831, York County, South Carolina, USA , d. 1857, Tennessee, USA (Age 25 years)
+ 4. James Thomas Darwin SUMMERFORD, b. 13 Apr 1833, York County, South Carolina, USA , d. 04 May 1900, York County, South Carolina, USA (Age 67 years)
5. Lucinda SUMMERFORD, b. 07 Jul 1837, York County, South Carolina, USA
Born - 14 Aug 1803 - York County, South Carolina, USA
Census - Pamela Darwin (age 7) presumed in household of father, John Darwin - 1810 - York County, South Carolina, USA
Census - Pamela Darwin (age 17) presumed in household of father, John Darwin - 1820 - York County, South Carolina, USA
Census - Pamela Darwin (age 27) presumed in household of father, John Darwin (with daughter Elizabeth M. Darwin) - 1830 - York County, South Carolina, USA
Slave Transaction - "Nan" bequeathed to Pamela Darwin (age 33) in father's Will - 22 Nov 1836 - York County, South Carolina, USA
Will - Pamela Darwin (age 33) named a beneficiary in her father's Will - 22 Nov 1836 - York County, South Carolina, USA
Census - Pamela (Darwin) Summerford (age 37) presumed in household of husband, Isaac Summerford - 1840 - York County, South Carolina, USA
Census - Pamela (Darwin) Summerford (age 47) in household of husband, Isaac Summerford - 1850 - York County, South Carolina, USA
Died - 12 Jan 1880 - York County, South Carolina, USA
Buried - - Sharon, York County, South Carolina, USA
Married - - York County, South Carolina, USA
The Family Secret of Isaac and Pamela Summerford
Who was the father of Pamela Darwin Summerford's children?
[S20] BIB: 1880: Mary Darwin Hope Bible.
"Pamela Darwin b. 8-14-1803 d. 1-12-1880"
[S72] CEN: 1810 SC York.
[S133] WIL: SC-YO: 1836 Will of John Darwin, York County Will Book G, p. 544, July 1837.
"I will to my Daughter Pamela one Negro woman named Nan to belong to her and her children during their natural lives, Nan and her increase shall belong to Pamela and her heirs forever"
Pamela Darwin (age 33) named for an equal share with named siblings of balance of father's estate.
[S113] CEN: 1840 SC York.
"Pamelia Summerford, 48, F, b. York SC"
"Permelia Suferford, 57, F, b. York SC"
"John Darwin, b. 3-19-1755, d. 7-13-1837, and Jane Bland, b. 1-2-1762, d. 3-10-1827, m. 3-11-1783"
[S1] BIB: 1837: Darwin/Bland "Bible", Quarto Page Q.
"Isacc Summerford and Pamelia Darwin was Maried" (no date given)
"Isaac Summerford and Pamelia Darwin, 1-27-1822"
This date is likely a polite fiction: see article, The Summerford Secret.


Any dog can get lost... and some dogs just seem to have a natural proclivity to wander off!
In this post, we will explore a new way you can find your lost dog more easily and quickly with a nifty little gizmo called a Bluetooth Tile Mate (tile for dogs)!
Currently, the Bluetooth Tile Tracker comes in two styles. One is simply perfect in size and weight for attaching to your dog's collar.
Specifically, it's called a "Tile Mate" and Amazon sells them for $22.46 each. In fact, you can get a deep discount on Amazon if you buy a pack of four of them for Check on Amazon, bringing the price per Tile Finder down to about $15 each.
If you don't have multiple dogs and or don't want to give the extras away for holiday gifts (although they make the perfect give for other dog people!), you can also use them to find lost or stolen items such as your keys, laptops, cell phones, purses, and backpacks.
What Is The Tile For Dogs?
The Tile Mate has a thin square (or diamond) shape and it even has a little cutout hole on one of the corners making it easy to attach the tile mate to your dog's collar.
Each side is a little under one and one-half inches (37 millimeters precisely) and weighs about one-third of an ounce (9.3 grams precisely).
How Does The Tile For Dogs Work?
The Tile Tracker uses wireless BLE technology. BLE stands for Bluetooth Low Energy technology.
This has become a universal standard way of connecting devices together wirelessly. It uses shortwave radio waves to communicate inside the actual Bluetooth Tile Tracker.
Inside, is a Bluetooth transceiver that can both transmit and receive these shortwave radio wave signals with another device. In this case with your smartphone and or tablet.
You also get a very visual and easy to use smartphone app that makes it easy to wirelessly connect your smartphone to the Tile for pets you put on your dog's collar.
In this way, you can use several features in the app to find your dog if he or she should get lost.
There's a locate feature that allows you to see how close you are to your dog if he or she is still within a range of at least 100 feet.
The app will even display a map with a marker on it to show the last place your dog was if he or she gets out of range.
You can then go to that spot and try the locator feature again. You can also make the Tile for dogs play a tune so you can hear where your canine is. Even is he or she is hiding under a big pile of fall leaves!
Perhaps most amazing, you can activate a "LOST" signal if, you can't find your dog with the other features on the Bluetooth Tile Tracker.
This will send you an instant alert and an email when another user who has the Tile app running on their device comes within range of your dog!
The best part is, they won't even know they triggered this because it's 100 percent anonymous!
When this happens, you'll see the approximate location of your dog drawn on a map!
You can go to that spot to find your dog and or you can call someone in that vicinity for help. Example, a park ranger, a family member, a friend, or a business person closer to that area.
The primary reasons tile for dogs has quickly grown by far the largest global network of any Bluetooth tracking device is that their app is free to download and run!
They also encourage their users to get people to download and run the app as it increases the effectiveness of finding lost items (dogs!).
So, if you can get some of your neighbors in every direction from your home to download and run the app on their phone, you will very quickly increase your ability to find your dog should he or she run away.
You can also ask all your friends on social media to do the same and encourage those at shelters and dog events to encourage this too.
Tile Mate For Dog Walkers?
You can also chat this idea up with all the dog walkers in your neighborhood and in the park(s) where you walk your dog.
It's a mutually beneficial win win so most people will be very interested to hear what you have to say.
You can even demon state your little gizmo to them on the spot.
You can also talk with postal workers, UPS guys, FEDEX guys, pizza delivery people, and anyone else who travels through your vicinity about adding the app to their smart phones.
This is crowed-souring at its best and it truly works!
A road trip with your pooch -- what fun! A family vacation without the family dog would be, well.... less enjoyable, to say the least.
Dogs enrich our lives in so many ways and there's no better way to spend quality time when them than taking them with us when we travel... but there's a downside.... in these unfamiliar settings, they are much more likely to get lost.
If your dog gets lost away from, it can be much harder to find them. Tile Mate can be a solution to this.
Even if you don't want to have a Tile Mate hanging off your dog's collar all the time, you may want to consider adding one when you travel. Independent testing has shown that this Bluetooth tracker works for about a 120 feet radius (they advertise it to 100 feet radius).
So, if you stop at a rest stop and your dog scampers off and gets lost, you can whip out your smartphone and track that pooch for about forty yards in every direction and still be within range to use the hot and cold feature to pinpoint where your capering canine has gotten to!
If you dog manages to get out of range, you'll likely be in an area when traveling where there is a higher than normal concentration of cell phones connected to the Tile network.
You can mark your dog as "LOST" and get an instant alert, complete with a pointer on a map, to hone in on where your dog has gotten to!
Taking your dog along on a hike or when camping can amplify the fun many times over. It's fun to watch their canine nose go into overdrive and their tail happily wag as they trot along with you.
However, the downside can be that they get so excited by a squirrel, chipmunk, raccoon, rabbit, skunk, deer, or (you can fill in the blank here) that they get so excited they go off on a chase only to get lost in the process.
If this happens, you can easily use the green circle locate tool to quickly zero in on which direction your canine has gone, if she or he has turned in another direction, and how far they've gone.
Your odds of finding your dog before something bad happens (like a raccoon bites her) goes way up with such a powerful tool!
The Bluetooth Tile tracker (Tile Mate For Dogs) is an inexpensive and very effective tool for finding your lost dogs. The Tile global network already has tens of thousands of users and it continues to grow much larger every day.
Therefore, it's already a powerful crowd-sourcing technique to find lost dogs and it will only get better over time. You can also increase its power and usefulness by adding more people (for free) to the network, especially in the areas where your dog is more apt to be when they get lost!
We want to hear from you in the comments below... do you use the tile for dogs?