We live in a world where we can monitor every aspect of our lives, from the quality of our sleep to how well we drive.
Unsurprisingly, this has spilled over into the classroom with parents / caregivers, school directors and governments all intensely interested in how children are progressing and whether or not targets are being attained.
Busy teachers are expected to spend increasing amounts of time monitoring students, writing reports and reassuring concerned parents. Noticing progress generally leads to celebrating success, which is positive, but are we forgetting the most important people in the equation, the children themselves?
Primary teachers are excellent at catering for the needs of their learners, and plan lessons which include plenty of fun and games, songs and stories, and projects and crafts. So much so, that children are often completely unaware of just how much they are learning.
I'm sure you've all cringed to hear students answer the question 'what did you learn today?' with a resounding 'nothing', which we all know is far from true. We teach grammar and vocabulary. We teach the skills of reading, writing, listening and speaking. We work on behavior management and motor skills. We develop learning strategies and digital literacy. We enable children to work collaboratively and autonomously. The list goes on.
Changing that 'nothing' into an honest reflection of what happened in the lesson is neither difficult nor without benefits for everyone. Research suggests that when children are involved in the learning process their level of achievement increases; this entails knowing what they are learning, how they are learning it and what the teacher expects from them.
Self-awareness is one of the key life skills identified as essential for life in the 21st century. And importantly for us teachers, by helping children to notice, understand and talk about their own progress we reduce the amount of time we need to dedicate to convincing parents and caregivers that their child is on track and learning.
Start and finish each lesson by showing children a lesson menu and using it to discuss the lesson. I like to frame these as Can Do Statements, which work particularly well to highlight the learning that has taken place.
If at the start of the lesson children answer (or indicate non-verbally via thumbs up/down) 'yes', use this opportunity to find out what they already know and where the gaps are in their knowledge. That way you can spend your valuable lesson time on the things your students really need to work on.
By the end of the lesson the children should be able to answer 'yes' to at least some of the statements, and if they can't – you know what to focus on in the next lesson.
Lesson menus are a great way to engage children in the content of the lesson, and are also very reassuring since children can keep track of where they are in the lesson, giving them more autonomy and responsibility for their learning.
Finally, by finishing the lesson by discussing what was learnt, children leave much more able to share this information with their parents or caregivers.
Primary learners tend to take the fastest route to finishing an activity by giving one-word, incomplete or guessed answers. Often this means they do not get the full benefit of the activity, which is where success criteria can be instrumental.
Success criteria can be given for any task, and are essentially an extension of instructions which show children exactly what they need to do to be successful. Ideally students help the teacher formulate success criteria, which means first showing them what they need to produce.
If they are to write a postcard, show them an example and get them to analyze the important features. If they are to give a presentation then think about how you can model this. The model doesn't have to be good – a bad model can work extremely well in highlighting what not to do.
After the activity, students can use the success criteria to reflect on their own progress or peer assess with a partner. Teachers can also use them to give focused feedback which is meaningful to students.
You don't have to wait till the end of semester test to assess your students. As teachers we observe our students all the time, and keeping a record of what you notice provides key insights into student strengths and areas for development, and saves time in the long run.
Where primary learners are concerned, it's not only language we need to be aware of but a whole range of behavioral and developmental goals such as working alone and in a group, thinking creatively and critically, dealing with stress.
Praise, where deserved, is a great motivator and looking at a whole range of criteria means all children can be rewarded in the context of their own learning. Keeping an eye on each child as an individual helps avoid comparing children and inadvertently ranking them on their language abilities.
I hope these ideas for visible learning in the primary classroom are useful!
Hattie, J. (2012). Visible learning for teachers. Maximising impact on learning. Routledge.
Amanda Davies is an experienced teacher, teacher trainer, materials developer, author and editor, who has also worked extensively in Primary ELT academic management. She's passionate about young learner teacher professional development and regularly presents at conferences, writes articles and blogs, and trains teachers both face to face and online. She also works as an international educational consultant advising on young learner foreign language learning programmes. She's worked in the UK, Russia, Spain, Lebanon, Egypt and Turkmenistan, and is based in Poland. Amanda is the publications editor for the IATEFL Young Learners and Teenagers Special Interest Group.


Home / General Health and Well Being / Could This Be A Cure For Diseases Like Alzheimer's?
Nearly everyone would agree that those diseases that cause the most trouble for people seem to be increasing. Diseases like Alzheimer's, Parkinson's, and other forms of dementia. They rob people not only of their ability to do things, but, maybe worst of all, their ability to remember and recognize loved ones.
What if there was a medical treatment that showed promise of changing these kinds of diseases so that the person's physical and mental abilities were returned? What if this same treatment could cure diabetes and repair heart muscles after a heart attack and regrow blood vessels and even help those with severe damage to their brains and spinal cords repair that damage?
Such a medical treatment is being investigated right now.
Ever since the development of the microscope and physicians being able to see cells, germs, bacteria, and viruses, they have been pursuing ways to treat and/or cure these kinds of illnesses and injuries.
In 1960, what has the potential to become a significant medical breakthrough came about. This is the year researchers began harvesting adult stem cells from bone marrow. In 1998, they began cultivating embryonic stem cells.
Stem cells are cells that are able to change into specialized cells in your body. They are initially called undifferentiated, meaning not any specific kind of cell. But with the right kind of stimulation, they can become differentiated, or change into a specific kind of cell, almost any kind of cell your body may need.
Usually, stem cells come from one of two sources: human embryos and adult tissue.
Stem cells from Embryos are formed during a very early stage of development, most of the time about the first 3-5 days after a human egg is fertilized. These stem cells are genetically programmed to turn into whatever type of cell the developing baby needs. The scientific term for this ability is totipotent, the ability to become any type of cell.
Stem cells from adult tissue are found in several places in the body. These stem cells can remain dormant in the body for years until stimulated to begin reproducing by disease or tissue injury. Typically, these stem cells will only reproduce the types of cells in which they are found, an ability called unipotent. But adult stem cells also have the ability to continue reproducing themselves, guaranteeing a continuing supply.
Recently, researchers have been able to genetically reprogram some adult stem cells to act almost like embryonic stem cells. That is, they're able to develop into many other types of cells. These are called pluripotent stem cells.
If this reprogramming is successful, these cells may be used instead of embryonic stem cells and lower the risk of the body's immune system attacking them. Also, using these stem cells would do away with the ethical concerns of using embryonic stem cells.
Some stem cells have been found in the amniotic fluid that surrounds a baby in the mother's uterus, also. These are called perinatal stem cells.
Researchers and scientists are interested in stem cells for better understanding how the human body develops in the womb. While this is a beneficial reason for study, the application of stem cells in humans shows very real promise in the treatment of numerous physical conditions, also.
One of the major ways stem cells can be used for benefit is by rebuilding damaged tissue in the body. For example, for those needing an organ transplant in order to survive, the waiting list is often too long. There are far fewer organs available than are needed.
If stem cells can be stimulated to regenerate the cells needed to grow a new organ, the waiting lists for transplants could be eliminated. And, if the stem cells came from the person's own body, there would be no need for medications to stop the body from rejecting the new organ.
Researchers have been able to stimulate stem cells to grow new blood vessels in experiments with mice. They found the new blood vessels to be as good as the natural ones right next to them. Once this procedure has been perfected for use in humans, it will enable those who have significant blockages in major blood vessels in and to the heart to grow new vessels as good as ones that grew naturally.
For those who have had heart attacks, the use of stem cells to regrow new muscle tissue in the heart has great promise.
In some of the major brain diseases, such as Parkinson's and Alzheimer's, there is significant damage to parts of the brain that lead to the symptoms of the diseases. Using stem cells has the potential to re-grow those brain structures and relieve the symptoms. This use of stem cells could provide these sufferers with much greater quality of life.
Stem cells could potentially be used to help some organs reproduce cells that die or stop working. One example would be injecting stem cells into the pancreas to stimulate it to begin producing insulin in those suffering with diabetes.
For many years, stem cells from bone marrow have been used to regenerate healthy blood cells in people who have leukemia or sickle cell anemia. The procedure needed to harvest these stem cells is invasive and painful. Scientists are hopeful that stem cells from amniotic fluid can be used for this purpose instead.
Stem cells have been used already in the process of testing the effectiveness and safety of new drugs. This allows scientists and researchers to check whether these medications may be more harmful than beneficial for humans.
As in all areas of research that use humans either as providers or recipients of the researched product, there are controversies with stem cells and their use.
One of the concerns of many people centers around the use of embryonic stem cells. There are those who believe life begins at conception. With this in mind, removing the stem cells from even the earliest stage of a fertilized egg is destroying a human being. Thus, this kind of use would be unacceptable.
With the ability to extract embryonic stem cells from the umbilical cord, this concern would be eliminated. It appears these stem cells are the same as those from the fertilized egg. Removing stem cells from the amniotic fluid would also do away with this concern.
Another concern involves the claims that are many times used by those in the market to make money off of other people's problems. With the apparent success of stem cells in the treatment of some conditions, some providers make the case for these cells to be the 'magic bullet' that will cure any and all illness conditions or injuries.
Because people with serious illness conditions may be willing to try anything to get relief or 'cures', they jump on these claims and pay sometimes outrageous amounts for these treatments. Many times, the results are either of no benefit to the sufferer or may even make their conditions worse.
Science in general is making tremendous leaps in research and application. Nowhere is this more apparent than in research involving stem cells. The future of stem cells and their use appears to be an open field.
Recently, researchers in Edinburgh, Scotland, developed and successfully used a 3-D printer to make working stem cells. Living embryonic stem cells were produced by this printer. Over 95 percent of the cells were still alive and able to work twenty-four hours after being printed. Three days later, 89 percent of them were still alive and able to reproduce.
A bioreactor is a device that controls the biological environment of stem cells. Through precise control of this biological environment, researchers can provide the best environment for stem cells to reproduce and differentiate into whatever kinds of cells are needed. The control of differentiation is one of the major problems in using stem cells in medical applications.
A procedure called CRISPR is being used with adult stem cells to stimulate them to become pluripotent, or able to develop into many types of cells. CRISPR is used to prompt the adult stem cells to reprogram into these pluripotent cells. It works at the genetic level to produce stem cells that can be used for multiple purposes.
The results of research into stem cells is promising for application in many biomedical uses. There may come a time when a person's own stem cells can be harvested and programmed to develop the specific types of cells that person needs to overcome an illness or injury. That day is off in the future currently.
Stem cells have been successfully used for some applications for years. This success and the promise of future success has led many people to believe these cells can be the cure for any and all conditions. Unscrupulous providers here and abroad have jumped on the bandwagon to make money with false promises and failed applications.
Those who would hope to benefit from treatment with stem cells should be aware that research is ongoing and nowhere near finished. The federal Food and Drug Administration warns people to use only those providers approved by the FDA for treatment and only for those conditions which research has shown effectiveness.
Ongoing research into stem cells may provide substantial benefits for people who suffer from many serious illness conditions. At this point, the future looks promising. Especially when it is teamed up with advances in bioengineering that will increase the potential benefits for everyone.
Stem cells may not be the 'magic bullet' that people are seeking, but they clearly have great potential for the good of humans.


text:
The Great Furlough Crisis Of 2020: Will The Government Say Hello To Hi?
FAANGS
One of the phenomena of the past decade has been the rise and rise of the so-called FAANGS stocks, so much so that the likes of Apple, Amazon and Google have not only dominated every moment of our lives, their founders now wield more power than many politicians, and indeed, some countries. Most of these companies are consumer focused: swallowing our cash, to enrich the management and their shareholders.
The flow of money and the benefit has been a one-way street in the FAANGS era, with these giants using technology primarily to boost their profits. The cost of course is seen all around us in the pandemic environment, with ghost town city centres, versus an online shopping and delivery boom. All of this is set against an economic slump, driven by the fall of the leisure, travel and hospitality sectors.
Double Pronged Disaster
We are therefore looking at a double pronged disaster, technology companies benefitting from and accelerating the decline of the old economy. Until now, none of the technology has seemingly been unable to do anything beneficial to either reverse the fundamental deterioration due to Covid-19, or even been applied to lessen the blow.
Indeed, if there was a one aspect that needs to be addressed over all others, it would be what is universally forecast to be a tsunami of job losses in the UK once the Government's furlough scheme ends in the autumn.
In fact, we are already at the cliff edge. From the beginning of September employers will have to start topping up furlough contributions, ahead of the end of October when the safety net is removed completely.
Unemployment Armageddon
The problem of course is that there is no November 1 start date for the economy to revive to compensate for employers for having to pay their staff again. As payroll is the biggest drain on a company's finances, it is likely that rather than having to financially jump off a cliff most employers will simply let their staff go, and so we will have unemployment Armageddon on an unprecedented scale – in the millions.
Hi's Pay Asset Finance [PAF]
What can be done to prevent this scenario? Perhaps ironically, and uniquely, we may soon witness a tech company, in this case a fintech company, arrive just in the nick of time. Its mission is not to exploit the nightmare, but actually prevent it happening.
The initiative is the work of Scottish entrepreneur David Brown who has a background in invoice settlement and payment technology. He is CEO of fintech group Hi55, and proposes a Working Capital Jobs Retention Scheme (WCJRS).
Under this scheme the massive payroll burden of corporates would be underwritten by the banks and finance houses, once the Government agrees to WCJRS. The Hi system works because existing legislation already guarantees any arrears are paid in the event of a company's insolvency. Therefore, in theory, any payroll can be financed from that of your local restaurant to blue chip names such as British Airways.
Indeed, BA is certainly a case study for our times, having felt the brunt of the nosedive in travel. If it fell victim to an October 31 / Halloween end of furlough nightmare, the UK taxpayer could be on the wrong side of a £500m hit in the first year, and £300m annually thereafter. Indeed, the 12,000 staff already let go mean that the British public are facing a £124m bill annually, not including welfare benefits and lost taxes.
The difference to a company's balance sheet of not having to set aside payroll expenditure would be analogous to the difference between buying a car outright or leasing it. In current conditions with profits tumbling, the freed-up cash can make the difference between going bust or not, or investing into growing a business, or sitting on hands.
To illustrate the "night and day" difference, of with Hi or without, it may be worth investigating the following example:
Going back to BA a company with 30,000 employees, earning an average of £2,500 a month, would need to have £225m set aside to fund 3 months pay, whilst the future is very uncertain. Using Hi's [PAF], rather than £225m BA would require just £56.25m with finance costs of less than £500,000 a month. As well as the release of £168.75m, BA now has a choice of either just enjoying being under less financial pressure or using it to invest in its future. Clearly, in many cases, given the present environment, Hi could mean the difference between staying afloat or going under. In contrast if BA did check out, not only would a further 30,000 jobs be lost and seeking benefits but also HMRC would also lose circa £300m per annum in tax revenue, the finance costs surely look small in comparison to what's at risk?
Although Hi has both simultaneously captured the zeitgeist with its offering and is in the eye of the furlough hurricane, it is not an overnight sensation. It began in June 2019, with its technology platformed backed by Japanese IT services giant NTT. Hi already has a big chunk of the finance / funding ammunition it is ever going to need: partnerships with top supply chain finance firms which gives Hi access to over 100 financial institutions.
The Big Four accountancy firms were always going to be key, and Hi is already involved in advanced discussions, with regards to working capital / restructuring work. In addition, Hi's infrastructure includes APi's into all major timekeeping platforms such as Kronos, and API's for all payroll providers I.e. Sage in the UK who account for over 8m UK employee payslips per month.
FTSE 250 Client
Hi's first major client is a FTSE 250 company with 20,000 employees, so it has clearly hit the ground running. This is especially so given the way that the foundation work such as building its fintech platform with NTT, securing its legal frameworks, and building a liquidity pool are all in place.
Nevertheless, even though it is clear and logical that Hi is likely to be as significant an entity as the companies it is partnered with or has as clients, the urgency at the moment is all to do with what it could achieve on a practical basis. This is both as far as the UK jobs market in general, and in particular to prevent a surge in unemployment later this year at all.
Sunday Times Article
The Sunday Times has recently reported that Hi has caught the eye of the Bank of England, is being recommended to the Chancellor Rishi Sunak by the SNP, and has the support of former Chancellor Norman Lamont. However, with time rapidly running out until the end of furlough, the luxury of any leisurely consideration of the WCJRS has clearly come and gone. It seems paramount for jobs and the economy that the Government is able to act as quickly as possible to adopt Hi's initiative.
Pay On Demand
Hi with or without an estimated £5bn value in WCJRS, should be just fine in a cash strapped corporate environment with new customers rolling in. It can truly be said that it will be a company which helps, rather than just takes, like the FAANGS brigade.
Going forward we are looking at innovation: Hi's rollout will include weekly payroll, and then pay on demand, which effectively means that it will usurp part of the role and cost of banking services to consumers. Effectively, this will make Hi a challenger bank, but with the foundation of being a punchy financial entity in its own right via its new pay asset finance offering.
Swift Adoption
It is evident that Hi look set to grow rapidly. But without Hi's WCJRS initiative, the Government's finances and the economy could be staring into the abyss. The hope is Hi's current campaign for the adoption of its initiative is successful as soon as possible.

redpajama_set_name: RedPajamaCommonCrawl


Thank you for applying to the 2018 MAP Fund grant cycle!
We're writing to share some data collected from the full pool of MAP applications received this year. We believe this information, in the aggregate, tells an important story about the state of contemporary performance in the U.S. and beyond. Our aim is to use it to better understand the field's areas of heat and energy, its needs, strengths, and challenges, and ultimately to be better advocates. While we want to be careful to create a streamlined, minimalist application, we also welcome your thoughts about new questions we could be asking to get a clearer, more relevant picture.
We hope you'll have a look and respond with your thoughts!
We encourage you to send any additional questions or observations to mapinfo@mapfund.org.
This year, MAP received 839 applications (last year, we received 938 applications). A cohort of reviewers — 53 artists and arts professionals across the country, nominated by MAP's community — is currently evaluating those proposals. All applicants will be notified of Round One results by January 26, 2018. Read more about MAP's review process here.
Of the 839 applications we received, 801 were eligible for this year's grant cycle. The data gathered below is based on the eligible pool of 801 applications.
This year, we asked applicants to provide information about who was initiating and producing the project. 85% of the 2018 applications were artist-initiated, 13% of projects were initiated by institutions, and 2% were initiated by curators.
Applicants have the option to select one or more discipline identifications they would like their work to be reviewed under. 75% of the projects selected one discipline only (34% Theater, 27% Dance, and 14% Music). 21% of the projects identified two disciplines (9% Dance and Theater, 7% Music and Theater, 5% Dance and Music). 4% of the eligible applicants selected all three disciplines.
This year, artists had the option to submit either their artist statements in either video or written format. 88% of the artists submitted written statements, and 12% submitted video statements.
As a reminder, all applicants will be notified of Round One review results by January 26, 2018. Thank you for your application!


text:
On Wednesday, we celebrated the Day of the Finnish Language with a look at Mikael Agricola, the Finnish clergyman who is considered to be the founder of literary Finnish. While the celebration of the day coincides with the death of Mikael Agricola, it also coincides with the birthday of Elias Lönnrot, a Finnish physician and philologist. We feel a birthday is a much better reason to celebrate than somebody's death.
Sammatti, Elias' birthplace.
Elias Lönnrot was born in 1802 in the Grand Duchy of Finland. He studied his first academic year in the very same place that Agricola was acting bishop. However, the fire of Turku destroyed the university, forcing Lönnrot to move to Helsinki and graduate from the newly established university there which replaced the one in Turku.
He studied medicine and became a district doctor in Kajaani, in eastern Finland. Sadly, he was the only doctor for a population of around 4,000 people who lived across the length and breadth of a wide geographical area.
While his work in medicine seems depressing, it was really his work in linguistics that earned Lönnrot his fame. Lönnrot loved the Finnish language and collected folk tales in the language. He was a founder of the Finnish Literature Society in 1831 and as a result received financial support for his work.
He often took leave from his work as a physician to tour areas of Finland, including Lapland (where Santa lives) and part of Russian Karelia. His travels led to the writing of several books, and he was appointed to the Chair of Finnish Literature at the University of Helsinki thanks to his work preserving Finland's oral traditions.
He worked on the the Finnish-Swedish dictionary between 1866 and 1880, compiling over 200,000 entries in the process. Thanks to his experience with Finnish poetry he was considered a respected figure when it came to the Finnish language. Many of his translations had never been seen before and he coined many of the translations seen in the dictionary. Lönnrot also coined a number of neologisms when it came to scientific terminology with Latin or Greek roots.
Lönnrot's work with Finnish language is the second reason Wednesday was the celebration of the Finnish language. The work conducted by both Agricola and Lönnrot has been incredibly influential in the history of the Finnish language, and that is why Finland celebrated both of these great men in their efforts to preserve their mother tongue.
Labels: Finnish, Greek, History, Latin, science


Israeli Prime Minister Bibi Netanyahu is closer to forming a new coalition after the head of the Bayit Yehudi party relinquished his demand for the foreign ministry, political sources said, AFP reports.
Netanyahu, whose Likud party won a surprise victory in a March 17 election, has until May 6 to piece together a new government, after receiving a 14-day extension last week.
Despite a month of intensive negotiations, Netanyahu has not yet managed to form a coalition, expected to comprise six rightwing and religious parties and have 67 of parliament's 120 seats.
Bayit Yehudi leader Naftali Bennett, currently economy minister, had been demanding the foreign ministry, held now by Yisrael Beitenu leader Avidgor Lieberman. But over the weekend Bennett set his sights instead on the education ministry and formally asked Netanyahu for the portfolio.


text:
(function() {
	angular.module("aggstyleapp", ["restangular"]).config(function(RestangularProvider) {
                //set the base url for api calls on our RESTful services
		var newBaseUrl = "";
		if (window.location.hostname == "localhost") {
			newBaseUrl = "http://localhost:8080/api/rest/register";
		} else {
			var deployedAt = window.location.href.substring(0, window.location.href);
			newBaseUrl = deployedAt + "/api/rest/register";
		}
		RestangularProvider.setBaseUrl(newBaseUrl);
	});
}());

redpajama_set_name: RedPajamaGithub


Feasibility studies are our specialty and bring together the depth of skill and experience we offer in both the technical and commercial areas of mine development, mineral dressing, hydrometallurgy and downstream processing and mine production.
We work with clients to guide their projects from initial scoping through prefeasibility to final feasibility assessment. A recent trend, saving both time and resources, is to undertake a more advanced scoping study before proceeding directly to a Definitive Feasibility Study.
Studies are critical decision-making tools, not only shaping the design of a project, but also helping cement it's economics and reduce risk. The objectives of the study determine the scope and level of bankability required. Some are used for internal review and governance purposes, while others are used to attract equity funders or secure bank finance.
BatteryLimits has successfully delivered numerous feasibility studies, particularly for Australian and African resource projects, including graphite, gold, iron ore, vanadium and copper/molybdenum.


House Democrats are barreling ahead with their oversight of the Trump administration at a fiery Intelligence Committee hearing.
"There is a different word for that than collusion, and it's called compromise," Schiff said, as he opened the session. The hearing was called to provide an overview of how Russia in the past has blackmailed Americans.


text:
Clara Guatame, new president of the National Hydrocarbons Agency
This December 7, the Minister of Mines and Energy, Irene Vélez, appointed Clara Liliana Guatame Aponte, as president of the National Hydrocarbons Agency (ANH). The fact is historical because it is the first time that a woman presides over this entity.
(Read: Government launches offensive to monitor gunpowder factories).
Guatame is a geologist from the National University of Colombia, with a Master of Science from the same university. Likewise, He has more than 25 years of experience in the public and private sectors and the hydrocarbons sector.
He has held management positions in the National Hydrocarbons Agency where he was technical vice president in charge and manager of technical information and knowledgein charge of both functions.
He comes from working at the Colombian Geological Service and at the former Colombian Institute of Geology and Mining, Ingeominas.
Among the challenges he encounters upon his arrival is implementing the strategies aimed at ensure energy self-sufficiency, Obtain the feasibility of suspended contracts and support the execution of current contracts, within the framework of the sustainable development of the hydrocarbons sector.
Likewise, it must strengthen the relationship with the communities in the territory and the socialization of the fair, gradual, equitable and safe energy transition.
(In addition: Majorities of Congress sank a motion of censure against Minminas).
"At the ANH we are committed to generating scientific knowledge for strategic decision-making and implementing new hydrocarbon exploration and production technologies, especially gas, to increase current reserves.", affirmed Clara Liliana Guatame, during the ceremony of her possession.
Venezuelan linked to human trafficking network was arrested in Colombia
The Colombian Prosecutor's Office reported that the citizens Berta Ramírez
"Cro-Magnon crossed us all" Y "Music does not kill"the slogans to 18 years of Cromañón
Photo: Raul Ferrari. The group Hacemos Memoria, which brings together
embed note December 30, 2022, 21:12 PM December 30, 2022,
Indigenous federal deputy Joênia Wapichana will head Funai
Federal deputy Joênia Wapichana (Rede-RR) confirmed that she will assume
Former Cuban Major League Baseball Players Criticize the FCB's Call for the World Classic
FGV: rents were 0.36% cheaper in November
Latest from Colombia
Ministry of Health leaves the average UPC at 16.23% for 2023
Through resolution 2809 of December 30, the average Capitation Payment Unit (UPC) for 2023 will rise
Petro will travel to Brazil in possession of Lula da Silva
The Minister of Labor, Gloria Inés Ramírez, will assume presidential functions this weekend, during the trip
King Pele
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"W Contigo", financial education at a single click
The recommendations, articles, experiences and tips on the financial world are available in a digital space,
Why is this not a good time to get into debt?
This Friday, December 30, the Financial Superintendence of Colombia set the usury rate at 43.26% for


text:
/* ###
 * IP: GHIDRA
 *
 * Licensed under the Apache License, Version 2.0 (the "License");
 * you may not use this file except in compliance with the License.
 * You may obtain a copy of the License at
 *
 *      http://www.apache.org/licenses/LICENSE-2.0
 *
 * Unless required by applicable law or agreed to in writing, software
 * distributed under the License is distributed on an "AS IS" BASIS,
 * WITHOUT WARRANTIES OR CONDITIONS OF ANY KIND, either express or implied.
 * See the License for the specific language governing permissions and
 * limitations under the License.
 */
package help.screenshot;

import java.awt.*;
import java.awt.image.BufferedImage;
import java.util.concurrent.CountDownLatch;

import org.junit.Test;

import docking.DialogComponentProvider;
import generic.theme.GThemeDefaults.Colors;
import generic.theme.GThemeDefaults.Colors.Palette;
import ghidra.framework.cmd.BackgroundCommand;
import ghidra.framework.model.DomainObject;
import ghidra.util.task.TaskMonitor;

public class AutoAnalysisPluginScreenShots extends GhidraScreenShotGenerator {

	public AutoAnalysisPluginScreenShots() {
		super();
	}

	@Override
	public void loadDefaultTool() {
		// not tool for this test
	}

	@Test
	public void testAutoAnalysis() {
		Color darkGreen = Palette.GREEN;
		Color darkBlue = Palette.getColor("darkblue");
		image = new BufferedImage(700, 400, BufferedImage.TYPE_INT_ARGB);
		Graphics g = image.getGraphics();
		g.setColor(Colors.BACKGROUND);
		g.fillRect(0, 0, 700, 400);

		drawText("(1) User Disassembles Code", Colors.FOREGROUND, new Point(160, 30), 24);
		drawArrow(darkBlue, new Point(325, 35), new Point(325, 70));
		drawText("(new code)", darkGreen, new Point(270, 90), 24);

		drawText("(2) Function Analyzer", Colors.FOREGROUND, new Point(0, 150), 24);
		drawArrow(darkBlue, new Point(265, 82), new Point(180, 120));
		drawText("(new function)", darkGreen, new Point(100, 190), 24);

		drawText("(3) Stack Analyzer", Colors.FOREGROUND, new Point(10, 230), 24);
		drawArrow(darkBlue, new Point(50, 155), new Point(50, 205));

		drawText("(4) Operand Analyzer", Colors.FOREGROUND, new Point(180, 290), 24);
		drawArrow(darkBlue, new Point(300, 94), new Point(300, 260));
		drawText("(5) Data Reference Analyzer", Colors.FOREGROUND, new Point(280, 350), 24);
		drawArrow(darkBlue, new Point(350, 94), new Point(490, 325));

		Point p1 = new Point(447, 355);
		Point p2 = new Point(447, 395);
		Point p3 = new Point(690, 395);

		drawLine(darkBlue, 3, p1, p2);
		drawLine(darkBlue, 3, p2, p3);
		drawArrow(darkBlue, p3, new Point(404, 88));
	}

	@Test
	public void testCaptureAutoAnalysisOptions() {
		showAnalysisOptions("Data Reference");
		captureDialog(800, 400);
	}

	@Test
	public void testCaptureBackgroundAnalysisTasks() throws InterruptedException {
		CountDownLatch start = new CountDownLatch(1);
		CountDownLatch end = new CountDownLatch(1);
		TestBackgroundCommand cmd = new TestBackgroundCommand(start, end);
		tool.executeBackgroundCommand(cmd, program);
		start.await();
		waitForPostedSwingRunnables();
		captureWindow();
		end.countDown();
		int width = image.getWidth(null);
		int height = image.getHeight(null);
		crop(new Rectangle(width - 400, height - 120, 400, 120));
	}

	@Test
	public void testCaptureProgramOptions() {
		showProgramOptions("Analyzers");
		DialogComponentProvider dialog = getDialog();
		Component comp = findComponentByName(dialog.getComponent(), "Analysis Panel");
		setSelectedAnayzer(comp, "Reference");
		captureDialog(1000, 600);
	}

//==================================================================================================
// Inner Classes
//==================================================================================================

	class TestBackgroundCommand extends BackgroundCommand {

		private CountDownLatch start;
		private CountDownLatch end;

		TestBackgroundCommand(CountDownLatch start, CountDownLatch end) {
			super("Test", true, true, false);
			this.start = start;
			this.end = end;
			setStatusMsg("Applying Function Signatures");
		}

		@Override
		public boolean applyTo(DomainObject obj, final TaskMonitor monitor) {
			monitor.initialize(100);
			monitor.setProgress(65);
			monitor.setMessage("Applying Function Signatures");
			runSwing(() -> invokeInstanceMethod("update", monitor));

			start.countDown();
			try {
				end.await();
			}
			catch (InterruptedException e) {
				// so what?
			}
			return true;
		}
	}

}


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Hi, just a reminder that you're receiving this email because you have expressed an interest in Deborah Wilder, CCMI. Feel free to unsubscribe if you are no longer interested or have received this email in error. Thank you!
You may unsubscribe if you no longer wish to receive our emails.
Welcome to our newsletter! You will find important updates and industry related news, along with upcoming speaking events and educational opportunities. Thank you for your interest in CCMI.
Deborah Wilder
CCMI President
California Supreme Court Expands Definition of Prevailing Wages for Special Districts
The California Supreme Court recently ruled March 29, 2021 that prevailing wages are not limited to just construction related projects when it comes to public utility, reclamation and other special districts. Kaanaana v. Barrett Business Systems. The Court essentially ruled that any contracts Special Districts entered into must be paid at prevailing wages.
The court reasoned that the language in Labor Code Section 177(a)(2) specifically referencing special districts was different than the language relating to other agencies engaged in "public works". For the last 90 years prevailing wage or public works projects have been limited to construction or construction related projects, including construction, repair, remodeling, alternation, maintenance, emergency work and warranty work. Even though the California Department of Industrial Relations has continued to define the work performed under Labor Code Section 1720 et seq as restricted to construction related work, the court ruled, Section 1720(a)(2) provides that prevailing wage includes "work done for irrigation, utility, reclamation, and improvement districts, and other districts of this type." The court stated because this particular section of the code did not specifically call out construction and related work, that the interpretation was to expand the definition relating to Special Districts to include ALL work awarded by a public agency and paid for in whole or in part from public funds.
That means that contracts with a Special District will require prevailing wage for sorting recycling, computer consulting, computer technician work, janitorial services and more. This is a big financial hit for Special Districts.
So, what is the solution? ACWA, CASA and CSDA are working on a legislative correction. In the meantime, there is a provision in the California Labor Code and regulations that allow an Awarding Agency to request a wage classification and wage rates from the Director. The provision requires providing the DIR with 45 days notice before the Bid Date. If you need more information on this topic, please contact CCMI. dwilder@ccmilcp.com
UPCOMING SEMINARS AND SPEAKING OPPORTUNITIES
Upcoming Training: There is currently no in person training taking place due to COVID-19. However, here is where you can still get some prevailing wage training with Deborah Wilder and CCMI.
Want On-Demand Prevailing Wage Training in California? Contact LCPtracker Academy www.lcptracker.com
Join us virtually at ACWA's Semi Annual conference May 12th and 13th. Contact www.acwa.org for more details
Prevailing Wage Training for Public Agencies in California; May 26th 9 a.m. -11 a.m. Zoom Training For more information,. Contact Matt Morley at the City of Los Gatos MMorley@losgatosca.gov
Stop by and see us IN PERSON at the CSDA General Manager's Conference at Squaw Valley June 27-June 29. For more information, contact www.csda.net
Want to schedule your own prevailing wage workshop?
We will customize a workshop or webinar for you and your Agency/Company. Contact us at: info@ccmilcp.com
NEW BOOK UPDATE
What Every Contractor Should Know About Prevailing Wages, 3rd Edition.
Available through www.ccmilcp.com $45 inclusive of tax and shipping.
FROM THE INBOX....
You asked, we answered!
QUESTION: My workers are installing a granite countertop on a federally funded prevailing wage project. How do I know if this is carpentry work or stone mason work?
ANSWER: The federal Davis Bacon prevailing wage determination does not include a description of work or scope of work for many of the trades. As such, the DOL classifies workers based on the prevailing practice in the area where the project is located. While you may be able to ask a contracting officer (if your project is directly with the federal government), the U.S. DOL has said that a contracting officer's determination relating to classification of workers is not binding on the DOL. So, the best solution is to contact the Department of Labor's Government Enforcement Coordinators for the specific region in which the project is located. Find your contact at this link https://www.dol.gov/agencies/whd/government-contracts/contacts. Send them an email so that you can have their answer in writing. The answer may be different if your project is in California or New York or Georgia or Alaska.
Feel free to send your questions to info@ccmilcp.com
CCMI is not just another firm....
We are not merely a "consulting" firm, but rather a team of individuals who understand the needs of the Public Entity and contractors to "get the project done." Our staff includes retired contractors, auditors, attorneys and industry veterans.


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Yacht shipping versus yacht delivery under sail – which method really costs more and why?
Will Bruton
Depending on the size of your yacht and the distance between ports, the difference in price between yacht delivery and yacht shipping may be smaller than you think.
TAGS: Premiumyacht shipping
A transocean passage can be a cruising delight, but it can also represent a logistical challenge. Owners who are constrained by time through work and family commitments, or who need to have their boat in a certain place at a set time, be it for a regatta or a charter, may not be able to sail their own yacht to its next destination.
Over the past ten years the business of moving yachts has seen significant developments. Several delivery companies now offer the services of qualified crew, 24-hour engineering support and satellite tracking as standard. In parallel, global yacht shipping has expanded vastly, resulting in faster deliveries and more destinations covered.
What is the difference in price between yacht delivery by sail and yacht shipping?
We requested a quote to move a Jeanneau Sun Odyssey 44DS with a value of £250,000 from Antigua to Palma following the 2017 ARC.
By ship: we were quoted £12,900, including insurance and cradle rental. However, the shipment offered was later than the departure date we initially requested.
By sail: quoted £8,500, not including fuel (estimated at £1,400), marina fees (est. £250), and return flights for three crew to UK (est. £1,800) giving a total of £11,950.
Jeremy Wyatt, director of World Cruising Club, sees many yachts moved by both methods following events like the ARC.
"In general there are two types of cruisers, the 'traditional' liveaboards who will cruise the Caribbean then sail home to Europe or the US. More recently, though, we have seen more time-poor sailors, usually because they have not retired or are not able to spend extended periods sailing," he comments.
"These are the owners who would be expected to ship back home. The convenience to them is not needing to spend six weeks preparing and sailing a boat back via the Azores and [that convenience] outweighs the cost of shipping.
"There is also the argument that shipping saves wear and tear, which is a hidden cost of sailing it back. Some boats, particularly catamarans, are also not really suited to the North Atlantic route back to Europe."
ARC Europe: Crossing the Atlantic west to east is a very different experience
Trusted hands
Engaging a delivery company involves putting a valuable asset in the hands of a skipper and crew you have probably never met. So how do you decide if they are up to the job?
Simon Weeks is a freelance delivery skipper, based in Hamble, UK, who sails worldwide. "As a minimum, I would always ask for a skipper's CV, verifiable references, and some contact well in advance of the trip," he recommends.
Pete Green, owner of Halcyon Yacht Delivery, has developed clear criteria for both skippers and crew. "We run with a minimum of three crew on short and medium trips and four crew on transocean deliveries," he comments.
"Our minimum skipper qualification is RYA Yachtmaster Ocean with lots of previous experience. In terms of crew, on medium to long trips we insist that one of the two crew must be a RYA Yachtmaster Offshore and, on shorter trips, a Yachtmaster Coastal. The third crew member must have RYA Day Skipper or equivalent experience.
"Anyone going on a Halcyon delivery has to supply two referees who are followed up, plus either a face to face or telephone interview during which a short theory exam is undertaken to assess the extent of the crew's knowledge."
It is perhaps not surprising that, in a market where margins have been squeezed in recent years, not all yacht deliveries go to plan. "There are certainly some cowboys out there," comments Weeks. "We pick up numerous deliveries every year from owners that have been let down."
"There was one yacht we delivered from Spain to the UK that had been left by another skipper who decided he didn't want to finish the trip. We were given a list of defects that the previous skipper had identified."
"We were prepared for some maintenance before setting off but were surprised to discover that the yacht was absolutely fine. It turned out the list had been created so that the skipper could justify going home early."
How yacht delivery companies operate has also been publicly called into question on several occasions. Many operations rely on unpaid volunteer crew keen to build their experience, a practice that not everyone in the industry supports.
There have also been reports of skippers pressured to sail into unsuitable conditions. In 2012, Farnborough-based Reliance Yacht Management was successfully sued for negligence after the deaths of a delivery skipper and two crew.
The wear and tear inflicted on a yacht on a delivery passage is a major consideration. With brand new yachts, the job becomes particularly involved, explains Green.
"It's always a challenge to deliver a brand new yacht thousands of miles in perfect condition. We spend time bubble-wrapping every inch of the interior to protect it. Also, we don't use certain items, including the oven, and we put foil on the top of the hob to make sure it is protected."
"On the exterior, we check all fixtures and fittings before setting off to make sure blocks are secure, winches have been tightened to the deck sufficiently, and sails have been bent on correctly. Lifejackets and harnesses stay on deck to avoid scratching the interior."
At the other end of the scale, some yachts being delivered haven't been sailed in years. "It can be a tricky issue," comments Green.
"Nearly all delivery companies and skippers specify minimum levels of equipment as part of the contract, but boat condition can be more problematic. Contact will be made with the owner beforehand to establish the yacht's age and whether there has been a recent survey, but this only gives half the picture. My checklist includes all the seacocks, the rig, engine and much more."
Shipping routes
Shipping yachts has become an increasingly popular option for many owners in recent years. It's an appealing prospect, largely due to the inherent predictability of an operation that relies on big ships that can handle all but the worst weather with ease.
Credit: William Bruton
Shipping companies increasingly charter purpose-built vessels that speed up the operation further.
"It's possible to ship with the mast left up, the shore power connected and crane the boat straight into the water at the other end," explains Josh Flavell, a former delivery skipper who now works for Peters & May.
The list of destinations covered has also grown. "Whilst routes used to be dictated by the traditional yachting seasons and its major events, such as the ARC, today we are delivering to some of the world's remote cruising grounds as well. Alaska and Tahiti are two of the more far-flung places we sailed last year," reports Sander Shuurman from Sevenstar Yacht Transport.
The Oyster Yachts team in Palma manages many yacht handovers to and from shipping companies on behalf of owners. "It's a very popular option," explains Mark Durham, Oyster Palma's operations manager.
"Although the shipping fees appear higher than the professional delivery companies, higher wear and tear heading east across the Atlantic means many are choosing what is a much more predictable option.
"There are some downsides. One is [to do with] the vagaries of loading dates. It can lead to multiple rescheduling, both of the loading and offloading team's plans, and of course the planned program after arrival.
"Although the passage time will almost always be shorter than the own-hull sailing time, the additional costs incurred at each end due to delays can add substantially to the basic charges, so they should always be budgeted for as well."
Whilst yachts won't incur sail or motor maintenance issues, Hamish Burgess-Simpson, project manager from Oyster, warns that shipped yachts can arrive "truly filthy", depending on their loaded position on deck.
"The dirt washes off the topsides with a bit of effort, but it can be permanently ingrained in the canvas work," he adds. This dirt, generated largely by the ship's stacks, can be mostly avoided by ensuring your yacht is placed forward of the exhaust system, but it's still advisable to stow all canvas.
The price of moving a boat, whether by ship or delivery crew, can be hard to estimate. "In recent years the bottom line for owners has become increasingly price driven, so we try to provide quotes that include all of the major expenses, including cradle hire and insurance whilst the boat is in our hands," says Josh Flavell from Peters & May.
"Our costs vary quite significantly. If we are utilising a scheduled 'liner' service, then the cost can be higher as the ship sails whether it is full or not.
"However, where we are using a chartered service ship, [which accounts for] about 70 per cent of our shipping, we can often offer a much lower price."
Despite an ever-increasing choice of routes, some destinations will always require a delivery crew, or a combination of shipping and delivery. "We recently delivered a yacht to her owner's private island in the Western Isles," says Pete Green of Halcyon Yacht Delivery.
Photo Wayne Larris Photography/Peters&May
Hidden costs of yacht delivery and yacht shipping
Both shipping and sailing a yacht can potentially incur hidden costs:
Cradle hire: yachts being shipped are secured to the deck in cradles. Whilst you may own one, it may not be suitable for shipping. If it is, there will also be an additional cost of shipping the cradle itself or storing it ashore.
Insurance: many shipping companies include insurance from when the yacht goes into the ship's crane to when it comes out, but not all – check with your insurer in advance.
Berthing: ships are delayed sometimes, particularly due to loading and unloading.
Satellite communications: one owner we spoke to reported a satellite phone bill in excess of £15,000 following a transatlantic delivery. The data connection had been left open by accident by the delivery skipper. If allowing use of your own satellite communication equipment, agree terms in advance in writing.
Wear and tear: on long passages, particularly heading into prevailing weather systems, some wear and tear on equipment should be expected. Consider timing of cosmetic work to the yacht carefully and ensure running gear works freely before handing over to a delivery company.
Insurance: again, check your policy. Your insurer may specify requirements for the delivery which may go beyond the skipper's qualifications. Crew may also need to meet certain requirements.
William Bruton, 27, grew up in Lancashire and learned to sail in 2012. He now works as a freelance skipper all over the world, specialising in Oyster yachts. He is currently based in Japan.
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text:
Search Google for pictures, maps, or other visuals to supplement your speech. Tip: You can also try an Advanced Google Image Search. By selecting "Labled for Reuse" in the Usage Rights drop-down box, you'll ensure the images you use are not violating copyright licenses.
Images in Speeches
Adding visual elements (such as pictures, maps, or charts) can really enhance your speech. Make sure to always pay attention to copyright restrictions and give credit to the source for all images you use.
"Wikimedia Commons is a media file repository making available public domain and freely-licensed educational media content (images, sound and video clips) to everyone, in their own language. It acts as a common repository for the various projects of the Wikimedia Foundation, but you do not need to belong to one of those projects to use media hosted here. The repository is created and maintained not by paid archivists, but by volunteers."
Lynda.com Online video tutorials & training
Mac Lab
Did you know there is a Mac lab on the second floor of Newton-Hobson? It is mainly for media communication students, but you can use it for your presentations. See Prof. Lewis Knight for more information.
Video Editing on Mac
Apple - Final Cut Pro X
"Revolutionary video editing. Powerful media organization. Incredible performance. The future of post-production is here."
Presentations on Mac
Apple - Keynote for Mac
"Keynote for Mac makes it simple to create and deliver beautiful presentations. Powerful tools and dazzling effects bring your ideas to life. You can work seamlessly between Mac and iOS devices. And work effortlessly with people who use Microsoft PowerPoint."
This site has five different graphs and charts you can customize for your speeches. Once you choose a graph, you set the design, input the data, and add labels. Graphs can be printed, downloaded/saved, or emailed.
Create a Graph
Prezi is a virtual whiteboard that transforms presentations from monologues into conversations: enabling people to see, understand, and remember ideas.
Wordle is a free site that lets you input text (such as President Obama's acceptance speech, seen below) and generate a "word cloud." Words appearing more frequently receive greater prominence in the cloud.
This Creative Commons photo courtesy of http://www.flickr.com/photos/52473526@N00/3004046717/
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25th April 2018 1st November 2019
The Leisure Seeker (dir. Virzi)
Image: Donald Sutherland and Helen Mirren in The Leisure Seeker © Property of Sony Pictures Classics [Source: IMDB]
These two titans of the performative arts bring to life a runaway couple setting out on a voyage in their trusty old RV called The Leisure Seeker. What starts as an expedition of fun turns quickly into a bittersweet exploration of love and memories.
Director: Paolo Virzi. Starring: Donald Sutherland, Helen Mirren [15]
By far the greatest moments in The Leisure Seeker are when Donald Sutherland and Helen Mirren are flaunting their talents and sinking their teeth deep into their characters. To which are grounded but somewhat fluffed up representations of the reality, none the less they are resonating depictions and still hold some honesty towards the harshly real effects that dementia has. It's through this exploration of dementia that the film achieves its most heartrending moments, delivering touchingly melancholic lines of dialogue, punched home by the effective subtleties of the winning performances from Mirren and Sutherland. Both convey the love and challenging nature of this sort of relationship and help bolster the poignancy of this story, even though it is certainly one that has been explored with more finesse.
Sutherland's character is key to understand the messages behind the films normality, as he speaks of Hemingway and the falsely perceived banality of his simple writing technique. There is certainly a case to be made here for that perceived banality of these characters, challenged by the show of memories and John's (Sutherland) life before the illness. Mirren's cartoon accented Ella still holds all the complexity that drives the plot forward but stifling the growth and journey of the two leads is the uneven direction. As though the film is caught between arthouse deeply personal story of dementia and Adam Sandler's latest flick. It's never quite sure of what it wants to be, and the feel-good tone makes it all the more confusing, resulting in a unengagement with a good portion of the film.
This unengagement leads to a natural sigh of boredom as you watch the film push its clumsy emotional manipulation, but none of it lands or swoons. Thankfully there are certainly a few select moments that truly are tear-jerking, saved by an enthralling ending that leaves the film on a high note at the least. While The Leisure Seeker is unsure if it's seeking leisure or something more insightful, it does deliver on the most part in being a touching exploration of love and more importantly dementia and the effects it has, with two outstanding performances that are wasted on stale direction.
Posted in Film, ReviewsTagged 2018, Donald Sutherland, Helen Mirren, Paolo VirziBy Jake YoungLeave a comment
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The B&B is in the countryside on the outskirts of Burgos. There are 2 guestrooms, classical in style, in this sober and cosy house, and it is the ideal destination for anyone who wants to enjoy an unforgettable holiday close to nature. Burgos forest is quite near, as are the ruins of the beautiful Castle of Burgos, which was built around 1300.


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GENES EXPRESSED IN THE EMBRYO BRAIN RESPONSIBLE FOR DEVELOPMENT OF HIGHER CORTICAL REGIONS
Created: Monday, 29 October 2018 03:34
You will see from the posts below that there is only a 1-2% difference in DNA sequence between human and chimpanzee and 80% of the proteins of human and chimpanzee are different. The burning question is what are the differences (if any) between the genes expressed in embryogenesis, because these are the genes most likely responsible for the radical phenotype differences between human and chimp. The next step for me is to go to the gene databases and compare the genes below in human and chimp. These genes are all different from the 10 genes listed in the post below this one.
1. Changes in cerebral cortex size are governed by fibroblast growth factor during embryogenesis - We show that fibroblast growth factor 2 (FGF2) and FGF receptors are transiently expressed by cells of the pseudostratified ventricular epithelium (PVE) during early neurogenesis. A single microinjection of FGF2 into cerebral ventricles of rat embryos at E15.5 increased the volume and total number of neurons in the adult cerebral cortex by 18% and 87%, respectively. Microinjection of FGF2 by the end of neurogenesis, at E20.5, selectively increased the number of glia. Mice lacking the FGF2 gene had fewer cortical neurons and glia at maturity. BrdU studies in FGF2-microinjected and FGF2-null animals suggested that FGF2 increases the proportion of dividing cells in the PVE without affecting the cell-cycle length. Thus, FGF2 increases the number of rounds of division of cortical progenitors.
2. Ventricular zone gene-1 (vzg-1) encodes a lysophosphatidic acid receptor expressed in neurogenic regions of the developing cerebral cortex. - Neocortical neuroblast cell lines were used to clone G-protein-coupled receptor (GPCR) genes to study signaling mechanisms regulating cortical neurogenesis. One putative GPCR gene displayed an in situ expression pattern enriched in cortical neurogenic regions and was therefore named ventricular zone gene-1 (vzg-1). These analyses identify the vzg-1 gene product as a receptor for LPA, suggesting the operation of LPA signaling mechanisms in cortical neurogenesis. Vzg-1 therefore provides a link between extracellular LPA and the activation of LPA-mediated signaling pathways through a single receptor and will allow new investigations into LPA signaling both in neural and nonneural systems.
3. An RNA gene expressed during cortical development evolved rapidly in humans - The developmental and evolutionary mechanisms behind the emergence of human-specific brain features remain largely unknown. However, the recent ability to compare our genome to that of our closest relative, the chimpanzee, provides new avenues to link genetic and phenotypic changes in the evolution of the human brain. We devised a ranking of regions in the human genome that show significant evolutionary acceleration. Here we report that the most dramatic of these 'human accelerated regions', HAR1, is part of a novel RNA gene (HAR1F) that is expressed specifically in Cajal–Retzius neurons in the developing human neocortex from 7 to 19 gestational weeks, a crucial period for cortical neuron specification and migration. HAR1F is co-expressed with reelin, a product of Cajal–Retzius neurons that is of fundamental importance in specifying the six-layer structure of the human cortex. HAR1 and the other human accelerated regions provide new candidates in the search for uniquely human biology.
4. Neuronal Subtype-Specific Genes that Control Corticospinal Motor Neuron Development In Vivo - Within the vertebrate nervous system, the presence of many different lineages of neurons and glia complicates the molecular characterization of single neuronal populations. In order to elucidate molecular mechanisms underlying the specification and development of corticospinal motor neurons (CSMN).. Loss-of-function experiments in null mutant mice for Ctip2 (also known as Bcl11b), one of the newly characterized genes, demonstrate that it plays a critical role in the development of CSMN axonal projections to the spinal cord in vivo, confirming that we identified central genetic determinants of the CSMN population.
5. Functional and Evolutionary Insights into Human Brain Development through Global Transcriptome Analysis - Our understanding of the evolution, formation, and pathological disruption of human brain circuits is impeded by a lack of comprehensive data on the developing brain transcriptome. A whole-genome, exon-level expression analysis of 13 regions from left and right sides of the mid-fetal human brain revealed that 76% of genes are expressed, and 44% of these are differentially regulated. Of particular relevance to cognitive specializations, we have characterized the transcriptional landscapes of prefrontal cortex and perisylvian speech and language areas, which exhibit a population-level global expression symmetry. We show that differentially expressed genes are more frequently associated with human-specific evolution of putative cis-regulatory elements. These data provide a wealth of biological insights into the complex transcriptional and molecular underpinnings of human brain development and evolution.
6. Genomic imprinting and the differential roles of parental genomes in brain development - Certain genes are expressed either from the maternal or the paternal genome as a result of genomic imprinting, a process that confers functional differences on parental genomes during mammalian development. In this study we focus on the cumulative effects of imprinted genes on brain development by examining the fate of androgenetic (Ag: duplicated paternal genome) and parthenogenetic/gynogenetic (Pg/Gg: duplicated maternal genome) cells in chimeric embryos. Striking cell autonomous differences in the phenotypic properties of the uniparental cells were observed. Ag cells contributed substantially to the hypothalamic structures and not the cortex. By contrast, Pg/Gg cells contributed substantially to the cortex, striatum and hippocampus but not to the hypothalamic structures. Furthermore growth of the brain was enhanced by Pg/Gg and retarded by Ag cells. We propose that genomic imprinting may be responsible for a change in strategy controlling brain development in mammals. In particular, genomic imprinting may have facilitated a rapid non-linear expansion of the brain, especially the cortex, during development over evolutionary time.
7. Cell-cycle control and cortical development - The spatio-temporal timing of the last round of mitosis, followed by the migration of neuroblasts to the cortical plate leads to the formation of the six-layered cortex that is subdivided into functionally defined cortical areas. Whereas many of the cellular and molecular mechanisms have been established in rodents, there are a number of unique features that require further elucidation in primates. Recent findings both in rodents and in primates indicate that regulation of the cell cycle, specifically of the G1 phase has a crucial role in controlling area-specific rates of neuron production and the generation of cytoarchitectonic maps… Embryonic thalamocortical projections are likely to influence areal specification during early stages of corticogenesis by modulating proliferation.
8. Embryonic signaling centers expressing BMP, WNT and FGF proteins interact to pattern the cerebral cortex - Because noggin can induce Fgf8 expression, we examined noggin and BMP signaling in the Emx2 mutant. As the telencephalic vesicle closed, Nog expression was expanded and BMP activity reduced, potentially leading to FGF8 upregulation. Our findings point to a cross-regulation of BMP, FGF, and WNT signaling in the early telencephalon, integrated by EMX2, and required for normal cortical development. When endogenous BMP signaling is inhibited by noggin, robust Fgf8 expression appears ectopically in the cortical primordium.
9. Regional and Cellular Patterns of reelin mRNA Expression in the Forebrain of the Developing and Adult Mouse - The reelin gene encodes an extracellular protein that is crucial for neuronal migration in laminated brain regions. During embryogenesis,reelin was detected in the cerebral cortex in Cajal-Retzius cells but not in the GABAergic neurons of layer I. At prenatal stages, reelin was also expressed in the olfactory bulb, and striatum and in restricted nuclei in the ventral telencephalon, hypothalamus, thalamus, and pretectum. At postnatal stages, reelin transcripts gradually disappeared from Cajal-Retzius cells, at the same time as they appeared in subsets of GABAergic neurons distributed throughout neocortical and hippocampal layers. In other telencephalic and diencephalic regions,reelin expression decreased steadily during the postnatal period.
10. Independent Expression of the α and β c-erbA Genes in Developing Rat Brain - Thyroid hormone is important for normal brain development. Cellular responses to thyroid hormone are mediated by multiple nuclear receptors, classified into α- and β-subtypes. In the rat, expression of both the α and β genes results in several translation products. The differential temporal and spatial distribution as well as coexpression at comparable levels in certain brain regions suggest different roles for the c-erbA proteins during brain development and in the mature animal.


Veterinary infectious diseases is a module aimed at providing the student with in-depth knowledge of all aspects of diseases of food-producing and companion animals caused by viruses, bacteria, fungi and prions. The module is structured to enable students to discern which infectious diseases of animals are high impact diseases and which are of lesser significance in order of importance. The module covers the morphological and physico-chemical characteristics of the causative organisms and the epidemiology and pathogenesis of the diseases caused by them. Course candidates will also learn how to diagnose these diseases in both the living and dead animal, and the control strategies applicable, including control at the livestock/wildlife/human interface. Finally, course candidates will learn about the socio-economic importance of infectious diseases of animals with special reference to transboundary spread.


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Ralph John Cicerone (* 2. Mai 1943 in New Castle, Pennsylvania; † 5. November 2016) war ein US-amerikanischer Klimatologe, der sich mit der Chemie der Atmosphäre und dem Klimawandel befasste. Er war von 2005 bis 2016 Präsident der National Academy of Sciences und Vorsitzender des National Research Council.

Leben
Cicerone studierte am Massachusetts Institute of Technology (Bachelor-Abschluss 1965) und der University of Illinois at Urbana-Champaign mit dem Master-Abschluss als Elektroingenieur und Physiker 1967 und der Promotion 1970. Danach war er bis 1978 am Space Physics Research Lab der University of Michigan in Ann Arbor, wo er auch Assistant Professor war. Ab 1978 war er in der Abteilung Ozeanographie der University of California, San Diego und 1980/81 als Forschungschemiker am Scripps Research Institute tätig. Von 1980 bis 1989 war er Senior Scientist und Direktor für Atmosphärische Chemie am National Center for Atmospherical Research in Boulder. 1989 wurde er Professor in der Abteilung Geowissenschaften der University of California, Irvine, der er vorstand. 1994 wurde er Dekan der Fakultät für Physikalische Wissenschaften und von 1998 bis 2005 Kanzler der UC Irvine.

Forschungen zum Ozonloch
1973 wurde er mit Richard S. Stolarski von der NASA beauftragt, die mögliche Schädlichkeit von Chlor, das über die Abgase des geplanten Space Shuttle als HCl in die Stratosphäre gelangt, zu untersuchen. Dabei entdeckten sie die Wirksamkeit von Chlor-Radikalen als Katalysatoren beim Abbau der Ozonschicht. Unabhängig erforschten das Michael McElroy und Steven Wofsy in Harvard, ebenfalls in Zusammenhang mit dem Space Shuttle. Bei der Präsentation ihrer Ergebnisse 1973 in Kyoto auf der IAGA-Konferenz wurden ihre Beiträge aber kritisiert, da sie es vorzogen, das Space Shuttle als Quelle zu verschweigen und stattdessen Vulkanausbrüche heranzogen, die als Chlorquelle aber eine untergeordnete Rolle spielten. 1974 erschienen dann Artikel sowohl von Mario J. Molina und Sherwood Rowland (Nature) als auch von Stolarski, Walters und Cicerone (Science), die Fluorkohlenwasserstoffe als Quelle in den Blick rückten und das Thema wurde auch von der Presse aufgegriffen, so 1974 von der New York Times. Molina und Rowland, die von James Lovelock angestoßen 1973 mit der Forschung begannen, sowie Paul J. Crutzen erhielten dafür 1995 den Nobelpreis für Chemie.

Auszeichnungen und Mitgliedschaften
1979 wurde er mit der James B. Macelwane Medal ausgezeichnet, 1999 mit dem Bower Award and Prize for Achievement in Science. 2002 erhielt er die Roger Revelle Medal der American Geophysical Union. 2004 erhielt er den Albert Einstein World Award of Science.

Er war Fellow der American Association for the Advancement of Science, der National Academy of Sciences, der American Chemical Society, der American Meteorological Society, der American Geophysical Union (und von 1992 bis 1994 deren Präsident), der American Philosophical Society und der American Academy of Arts and Sciences.

Von 1977 bis 1979 war er Mitherausgeber des Journal of Geophysical Research.

Literatur
 Mario Molina und Kenneth Janda: Ralph J. Cicerone (1943–2016). In: Nature. Band 540, Nr. 7633, 2016, S. 342, doi:10.1038/540342a
 John P. Holdren und Marcia K. McNutt: Ralph J. Cicerone (1943–2016). In: Science. Band 354, Nr. 6316, 2016, S. 1107, doi:10.1126/science.aal4054

Weblinks

 InterViews: Ralph J. Cicerone. National Academy of Sciences, April 2004 (englisch; mp3, 68 Minuten, 57 MB).

Einzelnachweise

Klimatologe
Hochschullehrer (University of California, Irvine)
Fellow der American Association for the Advancement of Science
Mitglied der National Academy of Sciences
Mitglied der American Geophysical Union
Mitglied der American Academy of Arts and Sciences
Mitglied der American Philosophical Society
US-Amerikaner
Geboren 1943
Gestorben 2016
Mann

redpajama_set_name: RedPajamaWikipedia


text:
package org.lambda4j.consumer.tri.obj;

import org.junit.jupiter.api.Assertions;
import org.junit.jupiter.api.Test;

class ObjBiDoubleConsumerTest {

    @Test
    void of_givenExpression_returnsFunctionalInterface() {
        ObjBiDoubleConsumer<String> consumer = ObjBiDoubleConsumer.of((t, value1, value2) -> {
            Assertions.assertNotNull(t);
            Assertions.assertNotNull(value1);
            Assertions.assertNotNull(value2);
        });
        Assertions.assertNotNull(consumer);
    }

    @Test
    void of_givenNull_returnsNull() {
        ObjBiDoubleConsumer<String> consumer = ObjBiDoubleConsumer.of(null);
        Assertions.assertNull(consumer);
    }
}


The X-mas hacking sessions began with fast food. "Fast", because we went straight into hacking.
Thomas showed his progress with the software behind his Roboshock project, a bi-pedal robotics project. He has built an impressive UI to transform raw deta from different sensors into artificial "senses". Besides, he recently started on another project, a blood pressure sensor based on OpenCV.
At a different table, Michael was working on J5 for the Arduino Yun. While the Arduino community seems to be rather silent about this combination, there is a nice how-to of combining Cylon.js with the Arduino Yun.
Next, Kresimir and me were working on a basic starter project: An Arduino based alarm clock. Since I forgot my DS1307 RTC chip, we "simulated" the time with counters on the Atmega328. A separate blog post on the clock will follow. At this point, it is maybe interesting to mention the Tinyduino RTC shield.
Measuring time with an Arduino is rather easy, so, we progressed towards mounting an old Nokia 5110 display on an Arduino. This was great fun too, and is a topic for a different blog post too. By the way, if you are interested in professional Drone technologies, take a look at Ascending Technologies where Kresi works.
Then, we had the pleasure to welcome Martin Laarmann of the Munich Make team. After a great Make Munich 2014, Martin has started already preparing Make Munich 2015. Martin also mentioned the Modularis board (made in Munich), and a hacking project to make dispenser machines more fun.


text:
Jean Joseph Louis de Maleteste est un homme politique français né le  à Paris et décédé le  à Florence (Italie).

Secrétaire général de l'administration des contributions indirectes, il est député de la Côte-d'Or de 1815 à 1816, siégeant dans la majorité de la Chambre introuvable.

Sources

Naissance en mars 1781
Naissance à Paris
Décès en février 1861
Décès à Florence
Député de la Côte-d'Or
Député de la Restauration
Décès à 79 ans


What a little gem The Flint Barns is!
The Flint Barns has been stunningly restored from dereliction after the storm of 1987 and is truly a "home away from home", available to stay at on a catered basis, or to hire for functions, throughout the year. This is an ideal venue for all kinds of rural retreats, from family get togethers and reunions, school and educational trips, and business meetings and functions as well. A fantastic setting for celebrating a special occasion, or relaxing with friends.
All of the bedrooms, which vary from double through to 8 bedded shared rooms, are en suite and there are extra showers and toilets in the corridors if needed. There is disabled access on the ground floor with no stairs. The building can accommodate up to 45 people but is also available to smaller groups if required.
Full catering is provided on site by our resident chef, all produce is locally sourced and everything is prepared and cooked on site - so if you fancy just sitting with your feet up enjoying the wood burner and a glass of wine whilst we prepare all of the meals, then this is the place for you. Why not enjoy a big family roast, summertime barbecue or a group hog roast outside in the lovely courtyard.
The Barns is located in the perfect situation for lovers of the South Downs Way just a mile away, great countryside and also the seaside. A huge variety of walks and enjoyment await you. Set in the middle of the Rathfinny vineyard, it's just 1 mile to the idyllic village of Alfriston in the South Downs National Park, only 5 miles from the beach & Seven Sisters Country Park, and 30 minutes drive to Brighton.
Nestled in the far west of the Estate, The Flint Barns is where the old world meets the new. A stroll through the vines will allow you to fully appreciate the position Rathfinny holds in this iconic landscape. Learn about our vineyard and the way in which we will create our Sussex Sparkling. Explore the vineyard, the history and wildlife of Rathfinny Wine Estate.


Turntables are back with a vengeance, but time doesn't stand still. Technology's pace allows us to revisit problems and solutions of the past with new eyes and new means. Sempersonus looked at one of the older and most cherished drive systems – idler drives – and proceeded to iron out its kinks and foibles with modern technology and materials. The result surprised them and will surprise you. Starting with the drive system, motion is supplied by a 10-pole BLDC motor, epicyclically driving the aluminum platter through a low-elasticity rubber drive wheel. The motor is attached to a telescopic cradle using sorbothane rings for vibration decoupling.
The platter of the Sempersonus TE1, of medium weight (3.3Kg), is constructed from aluminium and acrylic with the major mass around its circumference for a greater Moment of Inertia. Its underside is covered in butyl rubber to quell any 'ringing'. It rotates on an inverted bearing design, its weight supported by opposing neodymium magnets. To top it off, we use a two layer rubber / cork mat, for further isolation. Everything ties together at an aluminium / acrylic composite chassis X-frame, for rigidity and vibration damping. The frame itself, bolts onto a plinth made from steel reinforced concrete, where all other parts – armboard, sideboards, power and control electronics – are also bolted to, on precision located mounting points. The inboard power supply, line filters the mains supply before converting it to 12V DC and stabilizing it. It then feeds the motor controller, which features electronic speed switching (33/45), along with quick spin-up and quick stop characteristics. The correct speed is constantly monitored and accurately maintained thanks to feedback from a 1000-step optical encoder. At the same time, the right amount of torque provided – i.e. the absolute minimum required at all times – is continually adjusted based on feedback from the current levels required by the motor.
Complexity is hidden, or rather function doesn't dictates form. Sempersonus strived for a classical, contained appearance, able to subtly fit into any decor and not scream about itself. Beautiful wood panels side frame the turntable, while all other surfaces are covered in Alcantara for a truly 'no-fingerprints left' finish and, if being honest, for a difference! The standard combination includes a Jelco SA-750EB arm and a Denon DL-110 cartridge. However, armboards for other arms can be supplied instead, with no additional charge. For protection from dust – and little fingers – an optional dust cover is available. It features a novel tilt/slide damped hinge that allows for a more compact vertical footprint. Also included is a useful holder for LP covers, enabling their display while the record is spinning.


In some ways, Óin was lucky. When Smaug fell upon the Lonely Mountain, the old dwarrow was not there. He had spent several weeks traveling to the Iron Hills to visit his mother's kinfolk and on his return, Óin camped a day's trek out.
The dwarf saw no reason to rush his journey when the weather was delightful and he was quite enjoying his own company. Although he loved his home, Erebor was a bustling kingdom and the healer could use a break from the many demands upon his time. There were always sick and injured to be seen to, often more than he could manage in a day.
So Óin was content with the knowledge that his apprentices were well-trained, both dwarves near to reaching a healer's mastery. His patients would be well taken care of with Brigda left in charge and the dwarf felt no guilt about allowing his feet to dawdle on the path.
However, when the healer crested the last rise, his sense of contentment vanished instantly. There should have been lights to greet him, the torches by the gates of Erebor ignited every evening when dusk began to fall. There should have been farmers rushing home and hunters carrying game back to their families while trading caravans camped outside the walls of Dale.
But Óin saw only death. He saw soot-covered ruins and charred corpses on the plain and his heart trembled in his chest.
The healer wandered through the valley in a state of shock, unable to comprehend how such utter destruction could have occurred while he was gone. It took him days to track down the survivors, days of worry and self-recrimination. Because the healer should have been there to help his kinsfolk; he should have been there to treat the injured and indeed, he was conscripted into duty as soon as he arrived. There were so many wounded and so few supplies with which to heal them. There were few who had the knowledge, the weight of Óin's grief growing deeper when his brother told him that both of his apprentices had died.


and give some good examples of the most popular beads.
The Multi-Faceted, Round, and Bicone Shapes are the most popular for making rosaries which may be offered for sale or for gifts. Most of the shapes are widely available in plastic, glass, and crystal.
Heishi (hee-shee) The literal meaning of heishi is "shell" and specifically refers to pieces of shell which have been drilled and ground into beads.
Rondelles and Seed Beads Used as separators between beads, these comes in a wide variety of shapes, sizes and colors.
Crimp Beads Tiny metal, hollow beads, used to separate beads and finish off ends on bracelets and cord rosaries. A special Tool is required for applying Crimp beads.
Aurora Borealis is a sparkling finish usually applied to crystal beads, but may also be found on some glass beads.
Fiber Optics are beautiful beads, and the name refers to the process of blending the colors. They have almost a pearly sheen to them. They are available in glass and Lucite, a very hard plastic. These are sometimes mistakenly referred to as "cat's eye" when offered in brown or a darker color.
Fire Polished beads give the same appearance as the aurora borealis but are usually less costly; the beads sparkle and shine and reflect light more readily than plain glass beads.
Metal Beads come in a variety of finishes, from glossy to matte, silver, gold and platinum. Some are made from actual precious metal over brass, but metal-look beads are also widely available in plastic. Beware of what you are buying as prices will vary drastically.
Miracle Bead - A heavy coat of lacquer makes these beads appear to glow from within. Usually more costly than Fiber Optic beads.
Vitrail is the appearance of a bead after a metal sulphate has been applied to the surface. Often called "stained-glass," vitrail beads give off a multi-colored sparkling sheen.
Wood Beads come in a variety of colors and finishes, the most popular and affordable being olive wood beads. Note: the holes drilled in wooden beads is often larger than that of plastic or glass beads. You will have to adjust the size of your eye pin closure accordingly.
Crystal is defined as a solid formed by the solidification of a chemical and having a highly regular atomic structure, while glass is a brittle transparent solid with irregular atomic structure. The key to crystal is it's perfect shape, and weight. For more than 100 years Swarovski crystals have been famous for their exceptional quality and clarity. Swavorski is a brand-name of Austrian Crystal. Both the Czech crystal and the Austrian crystal are equally as bright. The Austrian colors are more intense. The Austrian facets have sharper edges. Crystal beads cost more than glass, but if you are looking to create a fine rosary, weighty, and with perfect clarity, choose crystal over glass.
Lamp Beads are hand-made and will be among some of the most expensive beads you will find, 50 cents to $1.00 plus, per bead. These beads are usually made of glass, and are hand-painted, but give the appearance of a precious stone, such as the cats eye shown above. Use 6 of these beads for the Paters to make a truly special rosary.
Oval and other oblong shaped beads are offered in " W x L " sizes such as 4 x 7 mm. The first number is the width; the second the length. Order your beads by length size. Round beads and near-round beads are offered in "X" size mm. Order your round beads by diameter size, such as 8mm.
Sometimes, beads are sold by the strand. For best value, buy your beads by the stand.
Enamel Colored, opaque glassy material fused onto metal, pottery or glass. In its simplest terms, all enamel is produced by fusing colored powdered glass to metal to produce a vitreous or glass-like, decorative surface.
Etched Very faintly carved decoration scratched onto the surface of a piece.
Facet Facets are the small flat surfaces of a glass, crystal or gemstone bead. These polished, flat planes are a major determining factor in enhancing the bead's ability to sparkle or reflect light. A Faceted bead or gemstone carved with a regular pattern of many planes, or "facets".
Gemstone A precious or semiprecious stone that may be used as a jewel when cut and polished. Include diamond, beryl, emerald, chalcedony, agate, onyx, tourmaline, chrysolite, sapphire, ruby, spinel, topaz, turquoise, zircon, cubic zirconia, jacinth, hyacinth, carbuncle, amethyst, alexandrite, cat's eye, bloodstone, hematite, jasper, moonstone, sunstone, and many others.
Laminated An object coated with a thin layer of plastic is said to be laminated.
Opaque A substance which is not transparent or translucent. i.e. a substance that does not allow light to pass through it.
Precious Stones Rare and costly gems such as diamonds, emeralds, rubies, and sapphires.
Retail You pay a merchant's full retail price for beads and supplies.
Semi-Precious Stones They are natural stones including amethyst, aventurine, carnelian, garnet, opal, rose quartz, and so on. . . used in fine rosaries, and may be referred to as Gemstones.
Translucent Allowing light to pass through, but not transparent.
Transparent A substance that allows light to pass through it easily and objects placed on the back can be fully seen through the substance.
Wholesale The sale of goods in large bulk or quantity for resale by a retailer or jobber rather than directly to consumers. A Rosary makers best value for beads and findings.