text:
namespace Dropbox.Api.Files
{
    using sys = System;
    using col = System.Collections.Generic;
    using re = System.Text.RegularExpressions;

    using enc = Dropbox.Api.Stone;

    /// <summary>
    /// <para>The invalid property group error object</para>
    /// </summary>
    public class InvalidPropertyGroupError
    {
        #pragma warning disable 108

        /// <summary>
        /// <para>The encoder instance.</para>
        /// </summary>
        internal static enc.StructEncoder<InvalidPropertyGroupError> Encoder = new InvalidPropertyGroupErrorEncoder();

        /// <summary>
        /// <para>The decoder instance.</para>
        /// </summary>
        internal static enc.StructDecoder<InvalidPropertyGroupError> Decoder = new InvalidPropertyGroupErrorDecoder();

        /// <summary>
        /// <para>Initializes a new instance of the <see cref="InvalidPropertyGroupError" />
        /// class.</para>
        /// </summary>
        public InvalidPropertyGroupError()
        {
        }

        /// <summary>
        /// <para>Gets a value indicating whether this instance is PropertyFieldTooLarge</para>
        /// </summary>
        public bool IsPropertyFieldTooLarge
        {
            get
            {
                return this is PropertyFieldTooLarge;
            }
        }

        /// <summary>
        /// <para>Gets this instance as a PropertyFieldTooLarge, or <c>null</c>.</para>
        /// </summary>
        public PropertyFieldTooLarge AsPropertyFieldTooLarge
        {
            get
            {
                return this as PropertyFieldTooLarge;
            }
        }

        /// <summary>
        /// <para>Gets a value indicating whether this instance is DoesNotFitTemplate</para>
        /// </summary>
        public bool IsDoesNotFitTemplate
        {
            get
            {
                return this is DoesNotFitTemplate;
            }
        }

        /// <summary>
        /// <para>Gets this instance as a DoesNotFitTemplate, or <c>null</c>.</para>
        /// </summary>
        public DoesNotFitTemplate AsDoesNotFitTemplate
        {
            get
            {
                return this as DoesNotFitTemplate;
            }
        }

        /// <summary>
        /// <para>Gets a value indicating whether this instance is Path</para>
        /// </summary>
        public bool IsPath
        {
            get
            {
                return this is Path;
            }
        }

        /// <summary>
        /// <para>Gets this instance as a Path, or <c>null</c>.</para>
        /// </summary>
        public Path AsPath
        {
            get
            {
                return this as Path;
            }
        }

        #region Encoder class

        /// <summary>
        /// <para>Encoder for  <see cref="InvalidPropertyGroupError" />.</para>
        /// </summary>
        private class InvalidPropertyGroupErrorEncoder : enc.StructEncoder<InvalidPropertyGroupError>
        {
            /// <summary>
            /// <para>Encode fields of given value.</para>
            /// </summary>
            /// <param name="value">The value.</param>
            /// <param name="writer">The writer.</param>
            public override void EncodeFields(InvalidPropertyGroupError value, enc.IJsonWriter writer)
            {
                if (value is PropertyFieldTooLarge)
                {
                    WriteProperty(".tag", "property_field_too_large", writer, enc.StringEncoder.Instance);
                    PropertyFieldTooLarge.Encoder.EncodeFields((PropertyFieldTooLarge)value, writer);
                    return;
                }
                if (value is DoesNotFitTemplate)
                {
                    WriteProperty(".tag", "does_not_fit_template", writer, enc.StringEncoder.Instance);
                    DoesNotFitTemplate.Encoder.EncodeFields((DoesNotFitTemplate)value, writer);
                    return;
                }
                if (value is Path)
                {
                    WriteProperty(".tag", "path", writer, enc.StringEncoder.Instance);
                    Path.Encoder.EncodeFields((Path)value, writer);
                    return;
                }
                throw new sys.InvalidOperationException();
            }
        }

        #endregion

        #region Decoder class

        /// <summary>
        /// <para>Decoder for  <see cref="InvalidPropertyGroupError" />.</para>
        /// </summary>
        private class InvalidPropertyGroupErrorDecoder : enc.UnionDecoder<InvalidPropertyGroupError>
        {
            /// <summary>
            /// <para>Create a new instance of type <see cref="InvalidPropertyGroupError"
            /// />.</para>
            /// </summary>
            /// <returns>The struct instance.</returns>
            protected override InvalidPropertyGroupError Create()
            {
                return new InvalidPropertyGroupError();
            }

            /// <summary>
            /// <para>Decode based on given tag.</para>
            /// </summary>
            /// <param name="tag">The tag.</param>
            /// <param name="reader">The json reader.</param>
            /// <returns>The decoded object.</returns>
            protected override InvalidPropertyGroupError Decode(string tag, enc.IJsonReader reader)
            {
                switch (tag)
                {
                    case "property_field_too_large":
                        return PropertyFieldTooLarge.Decoder.DecodeFields(reader);
                    case "does_not_fit_template":
                        return DoesNotFitTemplate.Decoder.DecodeFields(reader);
                    case "path":
                        return Path.Decoder.DecodeFields(reader);
                    default:
                        throw new sys.InvalidOperationException();
                }
            }
        }

        #endregion

        /// <summary>
        /// <para>A field value in this property group is too large.</para>
        /// </summary>
        public sealed class PropertyFieldTooLarge : InvalidPropertyGroupError
        {
            #pragma warning disable 108

            /// <summary>
            /// <para>The encoder instance.</para>
            /// </summary>
            internal static enc.StructEncoder<PropertyFieldTooLarge> Encoder = new PropertyFieldTooLargeEncoder();

            /// <summary>
            /// <para>The decoder instance.</para>
            /// </summary>
            internal static enc.StructDecoder<PropertyFieldTooLarge> Decoder = new PropertyFieldTooLargeDecoder();

            /// <summary>
            /// <para>Initializes a new instance of the <see cref="PropertyFieldTooLarge" />
            /// class.</para>
            /// </summary>
            private PropertyFieldTooLarge()
            {
            }

            /// <summary>
            /// <para>A singleton instance of PropertyFieldTooLarge</para>
            /// </summary>
            public static readonly PropertyFieldTooLarge Instance = new PropertyFieldTooLarge();

            #region Encoder class

            /// <summary>
            /// <para>Encoder for  <see cref="PropertyFieldTooLarge" />.</para>
            /// </summary>
            private class PropertyFieldTooLargeEncoder : enc.StructEncoder<PropertyFieldTooLarge>
            {
                /// <summary>
                /// <para>Encode fields of given value.</para>
                /// </summary>
                /// <param name="value">The value.</param>
                /// <param name="writer">The writer.</param>
                public override void EncodeFields(PropertyFieldTooLarge value, enc.IJsonWriter writer)
                {
                }
            }

            #endregion

            #region Decoder class

            /// <summary>
            /// <para>Decoder for  <see cref="PropertyFieldTooLarge" />.</para>
            /// </summary>
            private class PropertyFieldTooLargeDecoder : enc.StructDecoder<PropertyFieldTooLarge>
            {
                /// <summary>
                /// <para>Create a new instance of type <see cref="PropertyFieldTooLarge"
                /// />.</para>
                /// </summary>
                /// <returns>The struct instance.</returns>
                protected override PropertyFieldTooLarge Create()
                {
                    return new PropertyFieldTooLarge();
                }

                /// <summary>
                /// <para>Decode fields without ensuring start and end object.</para>
                /// </summary>
                /// <param name="reader">The json reader.</param>
                /// <returns>The decoded object.</returns>
                public override PropertyFieldTooLarge DecodeFields(enc.IJsonReader reader)
                {
                    return PropertyFieldTooLarge.Instance;
                }
            }

            #endregion
        }

        /// <summary>
        /// <para>The property group specified does not conform to the property
        /// template.</para>
        /// </summary>
        public sealed class DoesNotFitTemplate : InvalidPropertyGroupError
        {
            #pragma warning disable 108

            /// <summary>
            /// <para>The encoder instance.</para>
            /// </summary>
            internal static enc.StructEncoder<DoesNotFitTemplate> Encoder = new DoesNotFitTemplateEncoder();

            /// <summary>
            /// <para>The decoder instance.</para>
            /// </summary>
            internal static enc.StructDecoder<DoesNotFitTemplate> Decoder = new DoesNotFitTemplateDecoder();

            /// <summary>
            /// <para>Initializes a new instance of the <see cref="DoesNotFitTemplate" />
            /// class.</para>
            /// </summary>
            private DoesNotFitTemplate()
            {
            }

            /// <summary>
            /// <para>A singleton instance of DoesNotFitTemplate</para>
            /// </summary>
            public static readonly DoesNotFitTemplate Instance = new DoesNotFitTemplate();

            #region Encoder class

            /// <summary>
            /// <para>Encoder for  <see cref="DoesNotFitTemplate" />.</para>
            /// </summary>
            private class DoesNotFitTemplateEncoder : enc.StructEncoder<DoesNotFitTemplate>
            {
                /// <summary>
                /// <para>Encode fields of given value.</para>
                /// </summary>
                /// <param name="value">The value.</param>
                /// <param name="writer">The writer.</param>
                public override void EncodeFields(DoesNotFitTemplate value, enc.IJsonWriter writer)
                {
                }
            }

            #endregion

            #region Decoder class

            /// <summary>
            /// <para>Decoder for  <see cref="DoesNotFitTemplate" />.</para>
            /// </summary>
            private class DoesNotFitTemplateDecoder : enc.StructDecoder<DoesNotFitTemplate>
            {
                /// <summary>
                /// <para>Create a new instance of type <see cref="DoesNotFitTemplate"
                /// />.</para>
                /// </summary>
                /// <returns>The struct instance.</returns>
                protected override DoesNotFitTemplate Create()
                {
                    return new DoesNotFitTemplate();
                }

                /// <summary>
                /// <para>Decode fields without ensuring start and end object.</para>
                /// </summary>
                /// <param name="reader">The json reader.</param>
                /// <returns>The decoded object.</returns>
                public override DoesNotFitTemplate DecodeFields(enc.IJsonReader reader)
                {
                    return DoesNotFitTemplate.Instance;
                }
            }

            #endregion
        }

        /// <summary>
        /// <para>The path object</para>
        /// </summary>
        public sealed class Path : InvalidPropertyGroupError
        {
            #pragma warning disable 108

            /// <summary>
            /// <para>The encoder instance.</para>
            /// </summary>
            internal static enc.StructEncoder<Path> Encoder = new PathEncoder();

            /// <summary>
            /// <para>The decoder instance.</para>
            /// </summary>
            internal static enc.StructDecoder<Path> Decoder = new PathDecoder();

            /// <summary>
            /// <para>Initializes a new instance of the <see cref="Path" /> class.</para>
            /// </summary>
            /// <param name="value">The value</param>
            public Path(LookupError value)
            {
                this.Value = value;
            }
            /// <summary>
            /// <para>Initializes a new instance of the <see cref="Path" /> class.</para>
            /// </summary>
            private Path()
            {
            }

            /// <summary>
            /// <para>Gets the value of this instance.</para>
            /// </summary>
            public LookupError Value { get; private set; }

            #region Encoder class

            /// <summary>
            /// <para>Encoder for  <see cref="Path" />.</para>
            /// </summary>
            private class PathEncoder : enc.StructEncoder<Path>
            {
                /// <summary>
                /// <para>Encode fields of given value.</para>
                /// </summary>
                /// <param name="value">The value.</param>
                /// <param name="writer">The writer.</param>
                public override void EncodeFields(Path value, enc.IJsonWriter writer)
                {
                    Dropbox.Api.Files.LookupError.Encoder.EncodeFields(value.Value, writer);
                }
            }

            #endregion

            #region Decoder class

            /// <summary>
            /// <para>Decoder for  <see cref="Path" />.</para>
            /// </summary>
            private class PathDecoder : enc.StructDecoder<Path>
            {
                /// <summary>
                /// <para>Create a new instance of type <see cref="Path" />.</para>
                /// </summary>
                /// <returns>The struct instance.</returns>
                protected override Path Create()
                {
                    return new Path();
                }

                /// <summary>
                /// <para>Set given field.</para>
                /// </summary>
                /// <param name="value">The field value.</param>
                /// <param name="fieldName">The field name.</param>
                /// <param name="reader">The json reader.</param>
                protected override void SetField(Path value, string fieldName, enc.IJsonReader reader)
                {
                    switch (fieldName)
                    {
                        case "path":
                            value.Value = Dropbox.Api.Files.LookupError.Decoder.Decode(reader);
                            break;
                        default:
                            reader.Skip();
                            break;
                    }
                }
            }

            #endregion
        }
    }
}

redpajama_set_name: RedPajamaGithub


ClinAudits employs a team of subject matter expert consultants for regulatory compliance auditing projects of all sizes and scope. Our more than 57 auditors are regionally based throughout the U.S., Canada, South America, Eastern/Western Europe, China, India, Israel, Russia, Australia, Malaysia/Singapore and Japan. For all projects, our team employs quality control measures and follows appropriate SOPs to ensure that our work meets each client's high standards.
Globally experienced, we have conducted audits in Europe (East and West), Australia, New Zealand, Russia, China, Asia, Canada, Mexico, South America (Chile, Argentina, and Brazil), Latin America, the Caribbean, India, South Africa, Israel, and the United States.
Over the past 20-plus years, ClinAudits has amassed competencies a broad range of therapeutic areas including oncology, infectious disease, respiratory disease, central nervous system (CNS), virology, cardiovascular, ophthalmology, and dermatology in Phases I through IV of clinical research.
Domestic and International Clinical Research Trial Audits – established expertise in Good Clinical Practices (GCP) auditing to comply with FDA/EMA/MHRA regulations and other government regulatory authority regulations/guidelines, International Congress on Harmonization (ICH) Guidelines, specific company SOPs/guidelines and local governmental regulations/guidelines.
Contract Research Organization Audits – expertise in auditing CROs for sponsor's pre-qualification consideration and post-capability CRO study management/ CRO managed studies.
Central/Specialty Laboratory Audits – tracking clinical trial laboratory specimens through the laboratory environment to check for compliance with GCP and GLP, if needed.
Clinical Trial Supply/Drug Depot Audits – auditing all aspects of clinical trial supplies in accordance with FDA/EMA/MHRA, GMP, GCP and ICH regulations/ guidelines and other governmental regulatory authorities.
Institutional Review Board Audits/Ethical Committee – perform audits of IRB's (commercial, academic, private and hospital) and EC's in accordance with FDA/ OPHR guidelines/regulations and other international, local regulations/guidelines.
Audits of Final Study Reports/NDA submissions/Safety Reports/IND updates – audits of database in comparison to reports/ submissions to FDA or other governmental authorities.
Adverse Event Reporting System/Pharmacovigilance Audits – process audit of AERS, SAES, IND Safety report procedures within a country or between countries/ subsidiaries.
Computer Systems Validation Audits – process audit of software and hardware for GCP, GMP, GTP or GLP settings to guarantee security and consistency of data.
System/Process Audits, e.g., Mock-FDA, EMA, MHRA and other governmental authorities audits, electronic submission audits, clinical operations and monitoring, data entry and data management, biostatistical, and medical writing departments.
Training of Quality Assurance and Clinical Research Personnel – customized training to your SOPs.


I'm currently reading Emotionally Healthy Spirituality, and the author comments that we tend to define ourselves by our accomplishments. I certainly do. Specifically, I find a deep desire to do something truly great, to make a big difference. I want to look back at my life and see at least one giant contribution that made this world a better place, that helped many people.
Before I go any farther, I must clarify that I love Star Wars. I mean to criticize not the movie, but my own idolatry, or as Yoda would say "attachment". When I was a toddler, my mom would put the original Star Wars on for me. At the end, I would cry because it ended, so she put it on a second time. Same result, and a third time. This happened for about a month, and each viewing culminated in the throne room ceremony.
Putting these points together, I realized my life goal, my deep desire is to destroy a Death Star. Now, that is an incredible feat, a significant accomplishment. It is huge, decisive, and easily noticeable. This work has a clear beginning and end, and a few individuals can take the credit. It even results in recognition by a hundreds of people! While I doubt my repeated watching resulted in this desire, the film really portrays it well.
Clearly, Luke and Han play an indispensable role in destroying the Death Star. But in C.S. Lewis's The Lion, the Witch, and the Wardrobe, which also ends in a throne room, what incredible feat do the children accomplish?
Peter, Susan, Edmond, and Lucy defeat the white Witch. Sort of. They may have had clever tricks and brave moments, but they would have lost without Aslan. None of the four can take any credit for Aslan's resurrection or victory.
If not military success, what did they do worthy of reward? They stick close to Aslan, and they seek to help others. Of course, Edmond nearly ruined everything, but he still finds himself on the stage. Disregarding accomplishments, Aslan crowns them as kings and queens because they are "sons of Adam and daughters of Eve". Simply put, they are people, and people have value.
Even better than metals, they receive crowns. © Walt Disney Pictures.
Which Throne Room Do You Seek?
In Aslan, we find a picture of Jesus Christ who honors us, not because of what we do, but because of who we are.
This is not to say our actions don't matter. Surely, Edmond's treachery, which included his desire to rule over his brother and sisters, deserved punishment. He would not have become king had Aslan not sacrificed himself on Edmond's behalf, which symbolizes Christ's death for us.
Furthermore, our actions matter to others. The galaxy needed the heroic works of Luke and Han, and in Aslan's plan, Narnia needed the leadership of Peter, Susan, Edmond, and Lucy.
But, if God deems us valuable, worthy of love and honor, simply due to our being people made in His image, can I tell him, "You're wrong. I don't matter until I accomplish something significant."? I must not consider myself or my life incomplete until I destroy a Death Star.
Both Star Wars and The Chronicles of Narnia highlight a related fallacy. While I've already pointed out how the Pevensies could not take credit for Narnia's liberation, Rogue One emphasizes how many people play a crucial role in the destruction of the Death Star. It is not the work of two brave heroes, but the achievement of many.
Hence, hubris makes it my goal to do something great, at least in a way I could take the credit. In Star Wars, the will of the Force destroys both the Death Star and the Sith, bringing balance to the galaxy. In The Lion, the Witch, and the Wardrobe, Aslan saves the children and Narnia. In the real world, Jesus rescues us from our brokenness and will transform the world into utopia.
What life goal shall I pursue? From a desire to prove myself, shall I seek a great accomplishment? Instead, I must humbly do my role, which might appear small or big, in the great work that God is orchestrating. At the same time, I can rest in the knowledge that I already have immeasurable value.
What goal will you strive after? Are you enslaved to the illusory pursuit of the throne room of accomplishment, or do you receive honor from Jesus for simply being you?
Next Next post: Does Jesus follow Joseph Campbell's Hero's Journey?


If you become totally and permanently disabled, you may be eligible for a Disability Pension. You are considered totally and permanently disabled if you are totally unable, as the result of bodily injury or disease, to work as a Sheet Metal Worker or in other employment in the construction industry. You can be considered disabled and perform other types of work if you earn $35,000 or less per year. Your disability must be permanent for the remainder of your life.
You must file an application for a Disability Pension immediately upon medical confirmation of a total and permanent disability so you can begin receiving payments on a timely basis.
Medical evidence of total and permanent disability is required, and can consist of a Social Security Disability Award or other medical evidence acceptable to the Trustees. In most cases, you will be required to be examined by a physician or physicians selected by the Trustees.


As one of our newest agents, Brent has started his real estate career with great enthusiasm! Brent is a native of Birmingham, but has lived in several cities throughout Alabama. This gives him a unique perspective of our state and the clients that he encounters. Being one of the youngest team members (he's not even 30 yet!), he brings a fresh take to the home buying process and attracts many millennials who are looking to buy a home for the first time.
Why do you enjoy working with first time home buyers?
When I was a first time home buyer, I purchased my home through The Graham Group and had a great experience from beginning to end! I wanted to give that same experience to other first time home buyers. I know that homeownership was a big goal for me and want to help other first timers conquer that big goal for themselves.
Sellers- Be the Hero of Your Own Story!
A Birmingham native, Darius King has discovered that his passion for real estate sales goes far beyond loving real estate itself, but extends into loving the people that he's able to help on a daily basis. Darius started his real estate career in 2012 as an independent agent. After, doing that for a while he decided that the camaraderie and accountability that is provided on a real estate team is exactly what he wanted. Therefore, he joined the Graham Group in August of 2014.
Since joining the team, he has worked in a dual capacity role- as a buyers and listing agent. However, working with buyers is his greatest joy! Most agents know that working with buyers can sometimes be taxing, with constantly showing them homes. However, Darius loves helping buyers find the home of their dreams- no matter the time it takes to find it.
Clarence started his real estate career in 2005 as an investor! He bought and sold properties throughout Northwestern Birmingham, eventually venturing into multi-family units in the Avondale area. His love for all aspects of the real estate process prompted him to become a licensed agent in 2007, first working with Remax, then moving on to Keller Williams and he's never looked back!
Clarence is currently the founder and CEO of The Graham Group Real Estate Team at Keller Williams Vestavia. The team began in 2013, when his wife decided to leave her career as an educator and join forces with him. Since then the team has grown to include 4 other agents and 1 administrative assistant.
Warmer weather, spring break, and people are out and about! Yep, this sounds like the perfect time to sell your home! But is it?
In the world of real estate we call this the "real estate rush hour" and it begins in Spring. There are pros and cons to putting your home on the market at this time and we are here to help you weigh your options.
1. More competition. You're not the only person on the block who will consider testing the waters of the market during this time. If you know for sure you want to sell, go ahead and place your home on the market in Feb./or early March to bet the rush.
2. Availability: Service providers such as mortgage lenders, title and settlement companies, home inspectors and attorneys are more available during the off-season.


My level u starts to cut out after five minutes when connected to my Samsung chromebook and then it totally disconnects.
I don't think there's a problem with my chromebook. I really need a fix for this.
Hi Ahsonli. Have you tried using the device with other phones? Just to confirm it's working properly.


In the end result, PMG's SMO strategic orientation, as symbolized by the ballerina linebacker iconic imagery, is intended for the efficient attainment of goals. These vary widely in specificity from client to client, business to business, and from situation to situation. PMG sees things differently™, creates differently and deploys differently, all born of a dedicated governing strategy imbued with the finesse of a ballerina and the impact of linebacker…from Identity and Positioning through Messaging and Branding.
Positioning: Positioning is the logical foundation of all promotion and outreach…or it should be. PMG's Positioning services assist clients in determining the most precise and realistic bases for promotion and outreach…before Messaging and Branding efforts begin…thereby assuring the best potential for success. No major branding or sales effort can be successful over time without a distinct, well-honed and well-articulated position.
Identity: In strategic marketing, the word Identity begins with "W"… for who, what, when, where & why…the volcanic criteria of creation that must be rock solid to successfully navigate the minefield that is modern business in a highly competitive world.
Identity is multi not mono, broadband not linear. In PMG's world, Identity must be applied with laser precision…visually, in logos, color palettes, style guides…verbally, in taglines, sales positions, boilerplates…and virtually, in transferable platforms and translatable languages.
PMG creates the who, what, when, where & why of Identity for you.
Messaging: Messaging is both conduit and content in one, and it carries your values to the target audiences. Messaging is very often the make-or-break tipping point for a campaign or initiative. Those who utilize Messaging well and crystallize their thinking and expression are on the highway to success, while those who come up short have missed the bus.
PMG applies 40+ years of Messaging expertise every time we approach a program or a project. We are experts at conceiving, addressing, distilling, creating, clarifying, articulating, polishing, disseminating, managing and supervising all components of Messaging. That's a lot of "ings!" Heavy duty past perfect progressive tense! But it underscores the depth of thinking and scope of services involved in all PMG Messaging.
Branding: PMG's body of Branding work is exceptional and incorporates B2B, B2C and virtually all business models. As an SMO, we do the heavy lifting. Our solutions in industry-specific Branding efforts range from consumer and commercial to high-techs, uber-techs and non-techs…from defense, military and government to public services and private companies…for profit and not-for-profits.
Our Branding expertise is viable at all levels…OEMs, distributors, retailers, resellers, professional services, and compliance organizations…international and domestic.


The root of Panax quinquefolium L. (Fam. Araliaceae).
Originated in Canada and the U.S.A; introduced and cultivated successfully in northeastern, northern and northwestern China.
Dig out roots in autumn; remove above-ground parts and soil; remove rootstocks, lateral roots and rootlets; wash roots clean; dry under the sun or at low temperatures.
Spindle-shaped, cylindrical or conical. Outer surface light yellowish-brown or yellowish-white; marked with transverse annulations and linear (long and narrow) lenticels, and with fine, dense, shallow longitudinal wrinkles and scars of rootlets. Lower middle part of axial root with one to several lateral roots, mostly broken. In some cases upper end with rhizome; annular (ring-like) nodes prominent; stem scar orbicular (round) or semi-orbicular, with adventitious roots remaining or already broken. Heavy; hard and solid, does not break easily. Transverse section even, light yellowish-white, slightly starchy; cortex with yellowish-brown punctiform (dot-like) resin ducts; cambium ring brownish-yellow; xylem arranged roughly in a radial pattern. Odour: faint but distinctive; taste: slightly bitter, gradually sweet.
Mainly contains triterpene saponins such as ginsenosides Rb1,Rb2, Rc, Rd, Re.


Vegan Beet and Carrot Fritters - Eat. Drink. Shrink.
I don't know about you, but I love all things beets and fritters! Beets pack nutrients, a natural sweetness, and of course a gorgeous hue. Fritters on the other hand are this magical concept that has never ending combinations to keep your tastebuds on their toes.
What's fab about fritters ss that while they typically utilize egg as a binder, you can throw in a vegan egg without any issues. Fritters are a blank canvas so you can pair countless veggies and spices together and create the perf nutrient dense side dish or simply throw on a bun and make a slider if you're craving some carbs.
What's fab about this Beet & Carrot Fritter, is everything! It's quick, easy, affordable, nutrient packed, has a natural sweetness due to the natural sugar in both carrots and beets, perf for any season, have aesthetic appeal, can be thrown on bread to be more filling, can be made into smaller portions for more of a small bite appetizer, and non vegan approved!
If you love all things beets and or fritters, you have to try my recipe for vegan Beet Carrot Fritters!
Heat 1/2 tablespoon of oil in a large nonstick skillet and gently sauté the onion until it is soft but not browned. Add the garlic and cook for another two minutes. Set aside in large bowl.
Coarsely shred the boiled carrots and beets with a grater. Throw in the bowl. You can skip boiling the carrots if you don't mind texture, however I prefer a soft texture!
Combine the almond milk with the egg powder and add to the bowl with the remaining ingredients and combine well. Make the sauce by mixing all the ingredients together.
Heat 1 tablespoon of oil in a skillet. Cook fritter over medium heat until a crust forms on one side, then carefully turn each over and cook on the other side again until a crust forms. After the crust forms, reduce the heat and cook for four to five minutes on each side, or until the vegetables are cooked through.


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text:
'An absolute ad-lib from the start': the birth of Tom Petty's masterpiece Wildflowers
The late rocker's 1994 album is so heartbreakingly perfect, his band mates can't bear to listen to it today. They reveal how it was made
By Ian Winwood 28 Oct 2020, 12:53pm
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Tom Petty: his 10 best songs
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Fans share footage from Tom Petty's final concerts: 'I'm so glad I got to experience this'
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redpajama_set_name: RedPajamaCommonCrawl


How to Apply : The application is to be applied on line from02/04/2012 to 16/05/2012 at NBPPL website only. On submission, the system would generate an acknowledgement slip, the same is to be sent along with documents (i.e. self attested copies of mark sheet, Professional Degrees, Proof of date of birth, documents certifying the experience, NOC etc.) by speed post / Courier to The Recruitment Cell, HR Department, NBPPL, "The Corenthum", 6th Floor, Tower-B, A-41, Sector-62, Noida-201301 (U.P) on or before 23/05/2012.
Please visit Career section at NBPPL website athttp://www.nbppl.in/recent-opening for details and Online submission of application.


The idea of the project «The Fourth Entrance» has originated in 2008 and is associated with a place I used to live in. I did not analyze the reason, but I felt some features of the Middle Ages in that area. They are obviously the same for most similar residential districts: great concentration of depression, evil, and forced residence of people. Soviet panel skyscrapers reminded me of the Roman insulas – houses for poor people without any sewage. In our reality we have buildings with no light in corridors, burnt trashes, narrow and dirty elevators, and also neighbors, whom we never meet.
Now, I think, a kind of paradox has occurred – the past is ahead of the future. There is a theory in kabbalah, according to which there is no time. Namely all the events are on a huge chessboard and in parallel to each other. I did not know it before, but I imagined how different episodes, people and things could overlap.
That is how the images from other times appeared in ceremonial entrances of living blocks. It is a kind of the Medieval period which never ends.
Taras Shevchenko National Museum. Kiev, Ukraine.


text:
Being supportive
June 26, 2015 June 26, 2015 · 8 Comments ·
Yesterday, Trion Worlds teased a new game. If you go and take a look at the comments on Massively Overpowered, as well as on mmorpg.com, you'll see a lot of negative comments for a game that's only been teased as of right now. We don't know anything besides some art piece that serves as a background for a homepage. Of course, these comments don't attack the game, they attack Trion Worlds- and it makes me sad. Compare that to the positivity we saw when it was announced Trion would publish ArcheAge and you'll see Trion has a problem on its hands there.
But it's not only Trion. Daybreak can't get a break, as well, especially since it was announced that the dev priority is now in EQ Next and not Landmark anymore– but it's been negative ever since they went from being SOE to being Daybreak and a few high-profile employees left- or had to leave – the company.
Of course, Blizzard is making us pay subscriptions and for mounts in their cash shop while delivering content at a very slow pace and taking away flying for most people. We don't like Perfect World because of their monetization schemes. We dislike NCSoft for closing City of Heroes and/or Tabula Rasa (this is the one i miss dearly). Carbine is quite bad for delivering a raid endgame, ArenaNet has lost goodwill, as well, maybe since the perceived lack of delivering something akin to their design manifesto, maybe for overprizing HoT or something else entirely. Bioware turns SWTOR into a single player game and uses a f2p model where they make the customers pay and Funcom overpromises and does launches bad.
I think, right now, the only company who's somewhat seen in a positive light is Square for closing and reopening Final Fantasy XIV. While i think they deserve the praise, i think we shouldn't behave like that.
In defense of ArcheAge
I don't really see Trion at fault here- i mean, one could say that they should have looked at how exploits, hacks and so on work in that game- but in the end, they delivered a product we were wanting very badly. I think the hacking/exploiting was the main problem in AA, this is what sucked the fun out of it for me- because i felt that crafting and so on was made worthless if someone else could just cheat his or her way out of the system, especially with housing spots. But this stuff isn't really in Trion's hands.
Something tells me i'm going to take another look at this game
As for the cash shop? I don't know. Yes, selling Labor point potions might be a bit much, but i don't see it as critical- first of all, the labor point system was in place since before the game went free-to-play. Personally, i like a system like that, because there's a stop gap on what one account can do each day. It allows dirty time casuals like myself to not lose contact to others so quickly and it also makes players prioritize what they spend their LP on. You can learn and level all crafting professions in AA- labor points is used to maintain interdependancy in the game. If they didn't have that, crafters could just craft everything by themselves instead of trading with other players. This might be what we want, but in my opinion, this takes away some of the fun that is to be found in MMORPGs.
In defense of Trion
Myself, i really like Trion. I still do, even if i was quite disappointed at how ArcheAge turned out to be, as well. But if you'd take a look at their other games- you know, those they actually developed, namely Rift, Defiance and Trove, i think they are doing a decent job, especially with Rift and Trove. If you think Trion is a company desperately trying to "steal" your money, you should take a look at Trove. Regular, meaty updates that take player feedback into account and a monetization that is quite fair. I don't begrudge anyone trying to sell me something, i simply decide whether the game is fun to play and if what is offered/the prize it's asking is worth it to me.
We are customers, not fans
Massively Overpowered had this article about MMO terms that should just go away- for me, there are two terms that rub me the wrong way- first, it's when someone calls playing an MMO "work", as in "i worked so hard to get gear x,y and now they're nerfing it"- you're not working, you're playing a game. The second one is "fans". While it might be true in some ways, i think it creates a slightly off mindset. If you think about "fans", the first thing that comes to mind are sport teams- for us over here it's soccer/football, for north americans it might be american football/baseball and so on.
Now, fans of teams get passionate, they do. When things aren't looking so good for their team, they'll look for someone to blame, will probably find someone and will want him or her gone. But these fans always want the best for their team.
In the other direction, i think it makes devs feel to safe when they think about us, the players, the customers, as fans- there might be some fans to each games- i think all those who create fan sites should be considered fans- but the main body of us? We're customers- devs/publishers will have to offer a product that's worth its prize.
We should be more fan-like
I've stated before that in my personal opinion, MMORPGs are in a decline. It's not the license for printing money everyone thought it to be in 2006 to 2010. MOBAs used to be it, but i guess that time's over now, as well. Maybe survival is next (i think we've only seen indie survival games up until now). 2015 turned out to be a better year for MMORPGs than i thought when it began, but this is for existing MMORPGs, mostly. There are quite a few indie MMORPGs in development, and some of them might even be great (Repopulation and Shroud of the Avatar, looking at you here), but if we are honest about it, few of them, if any, should be considered Triple A. Those times seem to be gone.
I think we should be more positive with the people/devs who provide us with games from our favourite genre. I think especially developers, so those guys actually creating these games for us, are very enthusiastic about what they're doing- because frankly, i think there's more money to be made elsewhere with the skillset they have. I have little doubt, as well, that people like Scott Hartsman, Joel Bylos, John Smedley and so on love what they're doing. Maybe sometimes they'll make tough decisions we don't like, but they're doing this with the best intentions for their company, even if it might seem that it isn't in our- the customer's – best interest. But i don't think we can blame them for that- making games is also a business.
We might not be "fans" of certain games or certain companies, but we are fans of the genre and would benefit greatly if the genre was doing fine- in quality and quantity.
If all these companies we "don't like" are gone- who will provide us with the games we love to play?
So i'm looking forward to seeing what this new Trion game is, give them credit for what they've done with Rift and Trove, at least, and just hope it's something ambitious- either self-developed or published- we need that.
By the way, the best guesses i've seen so far seem to indicate it's possible that Trion might be publishing Lost Ark in NA/EU.
Edit: It looks like Devilian Online is a better guess.


Becoming a police officer in California requires formal training and may also require experience. Age requirements vary from one jurisdiction to another. A high school diploma is the minimum educational qualification, and some organizations prefer or require a college education. Police officers in California include the members of the California Highway Patrol as well as local police. The CHP may have different requirements than a local police force. Bilingual candidates may have an advantage in some areas of California.
All police officers need specific skills to be successful at their jobs. The U.S. Bureau of Labor Statistics notes that two important qualities are communication skills and empathy. Good judgment is necessary for high-stress or dangerous situations. Police often fill a leadership role in the community and must be comfortable with being highly visible to the public. A police officer should be able to anticipate what another person is likely to do and to understand people's motivations. Physical stamina and strength are necessary both to pass the entry tests and to perform many of the daily tasks involved in being a police officer.
California police officers must complete training at the police academy; CHP cadets attend the CHP academy. Training typically covers topics such as criminal law, cultural diversity, investigative procedures, defensive tactics, firearms, traffic enforcement, accident investigation and first aid. Prerequisites for the programs include a high school diploma or GED and the ability to pass physical agility tests. Police academy training takes about six months, and CHP academy training takes about a year.
Most police departments post their open positions locally, although some may also use online posting services and print publications to disseminate information. The CHP has a recruiting division, and applicants can obtain information there. Once an applicant completes the application, one or more interviews are typical. Some police departments may give preference to veterans. In addition, applicants can't have a felony conviction and must be citizens or permanent resident aliens who are eligible and have applied for citizenship. CHP officers must be citizens at the time of appointment. Applicants must also pass a background check that includes a criminal record review and check on their moral character. A polygraph test may also be mandatory.
Each police department may have specific requirements or preferences that a candidate must meet to become a police officer. For example, in Los Angeles, permanent resident aliens must not only apply for U.S. citizenship but become citizens within three years of their application date. Los Angeles also conducts financial background checks prior to hire. The Fresno Police Department specifically targets hiring members of minority groups, as long as they meet requirements. In San Francisco, people previously restricted from employment with the city or county of San Francisco can't become police officers. In the far northern California town of Redding, a prospective police officer must have completed at least 30 semester college units and have up to one year of street experience with a municipality, sheriff's office or the equivalent.
Greenwood, Beth. "How to Become a Police Officer in California." , https://careertrend.com/how-4488595-become-police-officer-california.html. 05 July 2017.


Guarding their time – Venessa Knizley "Author Mama"
This post has to do with a conversation I had with a friend. Last night, the thoughts were hers, but they're one's I've had before, and appreciated having to think about again.
One of the things that I've enjoyed the most about homeschooling is the freedom I've had to do life with people. If someone called and invited us over, dropping what we were doing or putting it off till later that day seemed an easy enough thing to do.
…only we usually didn't get around to doing it later, and then we'd lost a day of study. Well, no matter, right? Like most years, I'd just planned on homeschooling through the summer to catch up. It's not like you can do much else outside in 120 degrees. Except, I'm not homeschooling through the summer this year. Being unexpectedly pregnant and nauseous has changed all those plans. *sigh* Reminds me of that verse that says instead of us saying with certainty what we're going to do in the future, that we should instead be saying "As the Lord wills…" we shall do this or that.
So, the plans of this woman have been thwarted… and rightly so. It was pure lack of resolve that got me here. Resolve to finish what we'd started for the school year in a timely manner. And I'm really not a stickler for getting all the way through text books, but trust me… I had more to do. So, what my friend said to me yesterday finally hit home.
It's not fair to my kids to put off what is so important to their education… not even for some social interaction (and if I'm honest, it was always as much for me as for them. I need to see another adult now and again 🙂 ).
So this year, I'm going to guard their time. I'm going to be jealous for their education until they know enough to be so for themselves. I will set aside certain hours in the day for school and protect them. I will not multitask during this time period by doing housework, working on my book, or checking fb. I have a whole semester to set the tone before the baby comes. There again will be a time of change, but not in my resolve. I may be cuddling, nursing or toting around a newborn, but I won't give up their time… I mean, if the Lord wills, I will set aside the time He directs me to set aside 😉 and then guard it like a she-wolf!
Momma, be that she-wolf and write and tell us about it. I enjoyed your story, your dedication, and the words of strength.
Oh my goodness, thank you! Let me know what you think 🙂 and leave a review for me on Amazon if you think of it.
Yeah, I've been haVing the same thoughts as I plan for this coming school year. It's been easier with only one of my kids in school, but with my middle now starting officially, it's time to buckle down. It won't be as easy to Find time to catch up on two lessons instead of one. Like you said, gotta be a she-wolf. For me, it's an issue of planning ahead, instead of doing everything on the fly. It's not easy for me. Doesn't come naturally, but it's got to be done.


The popular notion of an antithesis between appearance and reality has exercised a very powerful influence on scientific and philosophical thought.
Guido clung to this thought like a drowning man clutching at a straw. He was rich and famous now, he told himself, and wasn't that what he'd always dreamed of?
I loved Old School. I thought Old School was very different than a lot of the comedies that had come out. And that character I liked. I tried to ground him very much in reality and play him very much finding things important to him that are somewhat ridiculous.


Background: Sputum analysis is used increasingly to assess airway inflammation in patients with chronic obstructive pulmonary disease, including those with chronic bronchitis and bronchiectasis. However, it is not known whether dithiothreitol (DTT), a reducing mucolytic agent regularly used to homogenise sputum, affects the detection of inflammatory mediators in the sputum soluble phase from such patients.
Methods: Thirty two spontaneous sputum samples were collected from 13 patients with chronic bronchitis and 17 with bronchiectasis. An aliquot from each sample was treated with either freshly prepared 0.1% DTT plus normal saline (NaCl) or NaCl alone, then ultracentrifuged to obtain the sputum sol phase. Interleukin (IL)-1β, IL-6, IL-8, leukotriene B4 (LTB4), secretory leukoprotease inhibitor (SLPI), alpha-1-antitrypsin (α1-AT), and tumour necrosis factor alpha (TNFα) were measured by ELISA, and neutrophil elastase (NE) and myeloperoxidase (MPO) by chromogenic substrate assay. The effect of DTT on the detection of assay standards was also determined.
Results: Median levels of IL-1β, IL-6, IL-8, SLPI, and NE were similar in the DTT and NaCl treated samples. There was a significant reduction in median (IQR) levels of detectable TNFα (0.07 (0.00–0.47) pM v 0.90 (0.06–6.98) pM, p<0.001), LTB4 (1.67 (1.31–2.64) nM v 2.29 (0.95–4.22) nM, p<0.05) and MPO (0.00 (0.00–0.00) mg/l v 4.48 (0.00–33.66) mg/l, p<0.001) and a small increase in the median α1-AT concentration (0.05 (0.03–0.08) nM v 0.03 (0.02–0.08) nM, p<0.01) in the DTT treated samples. DTT had no effect on the assay standards for IL-1β, IL-8 or TNFα, but at higher concentrations it did affect IL-6, SLPI, NE, and LTB4 standards (43%, 70%, 76% and 643% of control value for top standard, respectively) and at all concentrations DTT completely abolished MPO activity.
Conclusions: Sputum processing with DTT significantly reduces the detectable concentration of TNFα, LTB4 and MPO, and produces a small but significant increase in median α1-AT levels. To avoid this problem we recommend that an untreated aliquot of sputum be retained for cytokine analysis, unless the assay has been specifically validated.
Sputum analysis is used increasingly as a non-invasive method of assessing airway inflammation, both in terms of cellular indices and soluble mediators of inflammation.1–3 However, different methods of sputum processing—for example, the use of mucolytic agents such as dithiothreitol (DTT)—may influence the detection of these soluble mediators. Studies have confirmed that sputum treatment with DTT, and its optical isomer dithioerythritol (DTE), significantly improves total cell counts and cytospin quality.4,5 However, DTT also has the potential to interfere with the detection of inflammatory mediators in the sputum sol phase, either by affecting the three dimensional structure of proteins causing the release of mucus bound molecules, or by interfering directly with the immunoassay.
To our knowledge there have been no previous studies of the effects of sputum processing with DTT on the detection of the relevant inflammatory mediators in sputum from patients with chronic bronchitis and bronchiectasis. The comparison is important given that sputum processing protocols often include treatment of the sputum sample with DTT before cytokine analysis.8 We have therefore investigated the effect of sputum processing with DTT on the soluble phase concentrations of IL-1β, IL-6, IL-8, leukotriene B4 (LTB4), secretory leukoprotease inhibitor (SLPI), alpha-1-antitrypsin (α1-AT), tumour necrosis factor alpha (TNFα), neutrophil elastase (NE), and MPO. We have also examined the direct effect of DTT on the immunoassay for each mediator.
Thirty two spontaneous sputum samples were collected over 4 hours (from rising) from 17 patients with clinical and radiological evidence of bronchiectasis (mean (SD) age 64 (14) years, forced expiratory volume in 1 second (FEV1) 66.7 (24.7)% predicted, forced vital capacity (FVC) 87.2 (21.4)% predicted, FEV1/FVC 60.6 (14.0)%) and 13 patients with chronic bronchitis as defined by daily sputum production for at least 3 months of 2 consecutive years9 (mean (SD) age 60 (12) years, FEV1 40.2 (24.0)% predicted, FVC 71.4 (29.7)% predicted, FEV1/FVC 45.6 (16.2)%).
The protocol for sputum processing was modified from that recommended by Pavord et al.1 Two aliquots of whole sputum weighing approximately 1 g were taken from each sample. One was treated with freshly prepared 0.1% DTT (Sputolysin; Calbiochem Corp, San Diego, CA, USA) at a ratio of 4:1 (v/w) and the other with four volumes of normal saline (NaCl) as a control. After treatment each aliquot was briefly vortexed then rocked for 15 minutes at room temperature. An additional 4 volumes of NaCl was added to each aliquot which was then rocked for a further 5 minutes. The sputum sol phase was then obtained by ultracentrifugation (50 000g for 90 minutes at 4°C) and the supernatant stored at –70°C until required.
We have previously reported the validation of the IL-8, LTB4, SLPI, NE, and MPO assays for use with untreated sputum samples from patients with chronic bronchitis and bronchiectasis.12 The remaining assays (α1-AT, IL-1β, IL-6 and TNFα) were also validated using the same methods to ensure good recovery before the study reported here. The lower limit of mediator detection in sputum (which is greater than the lower limit of the assay due to the sample dilutions required to achieve mediator levels within the working range of the assay and to remove interference from elastase), intra-assay coefficient of variation, and the recovery of mediator from untreated sol samples spiked with a known amount are shown for each assay in table 1. Sol phase measurements were performed blind on coded supernatants and mediator concentrations below the lower limit of detection of the assay were taken as zero for statistical purposes.
To determine the possible effect of DTT on each assay, one volume of assay standard (at nine times the usual concentration of the top standard) was mixed with four volumes of DTT and four volumes of NaCl. The final concentration of the assay standard in the mixture was therefore equivalent to the concentration normally used for the top standard. For comparison, a set of standards was prepared without DTT—that is, one volume of assay standard (at nine times the usual concentration of the top standard) diluted with eight volumes of NaCl. Doubling dilutions were performed on each mixture to produce the recommended range of standards for each assay.
The median levels of IL-1β, IL-6, IL-8, SLPI, and NE were similar in samples processed with DTT and NaCl (table 2). However, the median levels of detectable TNFα, LTB4, and MPO were significantly lower in the DTT treated samples and there was a small but significant increase in the median α1-AT concentration in the DTT treated samples (table 2).
Agreement between the two methods of sputum processing for the detection of each mediator is shown in fig 1, according to Bland and Altman. As recommended by these authors, the data have been log transformed before analysis to produce differences that are unrelated to the mean. The mean difference, with 95% limits of agreement, for the log data is shown on each figure. The antilogarithms of these values—that is, the ratios of measurements by the two methods—are shown in table 3. Thus, the levels of IL-1β measured in NaCl treated sputum differed from that measured in DTT treated samples by 0.204–3.408 times that detected in DTT treated samples for most measurements. These limits of agreement were marginally narrower for α1-AT but were wider for the other mediators, particularly SLPI, TNFα, and MPO (table 3).
Mean differences ±2SD in (log transformed) levels of inflammatory mediators between sputum treated with dithiothreitol (DTT) and NaCl plotted against the mean of the two values for IL-1β, IL-6, IL-8, LTB4, SLPI, α1-AT, TNFα, NE, and MPO.
The addition of DTT did not influence the detection of the assay standards for IL-1β, IL-8, or TNFα. However, DTT did have an effect at higher concentrations on IL-6, SLPI, and NE standards (43%, 70%, and 76% of control value for top standard, respectively). This effect diminished with increasing dilution so that the measurement of the DTT treated standards was greater than 85% of the control value at a 1:32 dilution for IL-6 and SLPI, and at a 1:2 dilution for NE (fig 2A–C). Leukotriene B4 measurements were markedly increased in the DTT treated standards. The top standard was 643% of the control value and, although this effect again lessened at lower dilutions, the DTT standard remained 120% higher than the control at a 1:64 dilution (fig 2D). There were some differences in the two sets of standards for the α1-AT assay at higher concentrations of DTT, although the pattern was not consistent and beyond a 1:32 dilution the DTT standard was within 15% of the control value (fig 2E). Finally, DTT completely abolished the detection of MPO standards at all dilutions (fig 2F).
Results for assay standards treated with dithiothreitol (DTT) plotted against standards treated with NaCl for IL-6, SLPI, NE, LTB4, α1-AT and MPO. Dashed line indicates line of equality.
In this study we found that the median levels of the inflammatory mediators IL-1β, IL-6, IL-8, SLPI, and NE were similar in saline and DTT treated sputum. However, DTT treatment resulted in significantly lower median levels of TNFα, LTB4, and MPO, and a small but significant increase in median levels of α1-AT. Furthermore, agreement between the two methods of sputum processing was poor with wide 95% limits seen for all mediators measured.
There are a number of possible mechanisms whereby sputum processing with DTT could have affected the detection of inflammatory mediators in the soluble phase. The effectiveness of DTT as a mucolytic agent arises from the fact that, as a potent reducing agent, it is able to split the disulphide bonds present in mucus glycoproteins and thus release sputum cells for analysis.14 However, by the same mechanism as for mucus glycoproteins, DTT could also affect the three dimensional structure of the mediators or the antibodies to which they are bound and measured in enzyme linked immunoassays. We examined this possibility in the second part of the study by comparing the detection of assay standards that had been "treated" with DTT or saline at similar concentrations to that used for sputum processing. We found that DTT completely abolished MPO activity at all dilutions and at higher concentrations it significantly reduced the detection of the assay standards for IL-6, SLPI and NE, but produced spuriously high levels of LTB4 and, to some extent, α1-AT. The marked increase in LTB4 measured in DTT treated standards is probably the result of the competitive nature of this assay. The LTB4 present in the sample competes with a fixed quantity of peroxidase labelled LTB4 for a limited number of binding sites on a specific antibody. The amount of peroxidase labelled ligand bound by the antibody, determined by the colour reaction following the addition of tetramethylbenzidine (TMB), is inversely proportional to the concentration of unlabelled LTB4 in the sample. Therefore, if DTT interferes with antibody-ligand binding, neither the labelled nor unlabelled LTB4 will bind to the plate so there will be no colour change following the addition of TMB which would be interpreted as being due to high levels of unlabelled LTB4 in the sample. Alternatively, the peroxidase label of the antibody could be inhibited by DTT, but this would seem unlikely as peroxidase labelled antibodies are also used in the IL1-β and IL-8 assays and neither of these two assays were affected by DTT, presumably because the washing process removes any remaining DTT before the addition of the substrate. For the measurement of MPO we used a chromogenic substrate activity assay, as we have previously shown that the immune assay for this mediator gives poor recovery and is dependent on the degree of sample dilution and elastase content.12 However, the MPO activity assay was particularly susceptible to interference from DTT, which probably relates to reduction of either the reactive oxygen species generated by MPO in this assay or the hydrogen peroxidase substrate itself.
The effect of DTT on the measurement of assay standards did not always correspond to its effect on the detection of the mediators in sputum samples. This may relate to the sample dilution required to achieve mediator measurements within the working range of the assay (as for SLPI and NE), which may be sufficient to remove any interference from DTT on the assay performance. However, the dilutions at which the samples were assayed for IL-6 and LTB4 were within the range where DTT did affect these assays, yet the median levels of IL-6 were similar in the DTT and saline treated samples and the median level of LTB4 was reduced—not increased—in DTT treated samples. This suggests that, during the process of mucolysis, the activity of DTT is likely to be neutralised to some extent, thus reducing its consequent effect on the immunoassay. However, mucolysis with DTT may also cause the release of mucus bound molecules from the sputum. These may include binding molecules such as soluble receptors, carrier proteins, and autoantibodies, all of which have the potential to interfere with the detection of inflammatory mediators in immunoassays.15 This may explain the significantly lower median LTB4 and TNFα levels in DTT treated sputum samples despite the predicted effects of DTT on the assays (increased detection in the former and no effect in the latter). Finally, mucolysis with DTT could also release mucus bound mediator which may explain the small but significant increase in α1-AT seen in DTT treated sputum samples which were diluted sufficiently to remove any direct interference from DTT on the assay performance.
It could be argued that the reduced concentrations of TNFα, LTB4, and MPO in DTT treated sputum are not relevant when measuring these mediators in paired samples that have both been processed with DTT—for example, when comparing airway inflammation at the start and end of a treatment period. However, the effect of sputum processing with DTT on TNFα and MPO was to reduce measurable concentrations of these mediators to levels that were near to, or below, the lower limit of detection for the assay, thus reducing the likelihood of detecting any significant difference between two samples that have been processed in this way. Furthermore, the fact that DTT affects the detection of some mediators, and not others, would also make it difficult to relate the concentration of a mediator to its function when the whole sample has been processed with DTT.
This study has shown that the treatment with DTT of whole spontaneous sputum from patients with chronic bronchitis and bronchiectasis does not significantly affect median levels of IL-1β, IL-6, IL-8, SLPI, and NE, but does significantly reduce the median levels of detectable TNFα, LTB4, and MPO and produces a small but significant increase in the median α1-AT level. Furthermore, agreement between the two methods of sputum processing is poor, which suggests that they should not be used interchangeably for the measurement of inflammatory mediators. To avoid these problems we recommend that an untreated aliquot of sputum be retained for the measurement of inflammatory mediators unless the assay has been specifically validated.
Magnussen H, Hargreave FE. Noninvasive monitoring of airway inflammation. Eur Respir J2000;16:1–2.
Maestrelli P, Richeldi L, Moretti M, et al. Analysis of sputum in COPD. Thorax2001;56:420–2.
Efthimiadis A, Pizzichini MM, Pizzichini E, et al. Induced sputum cell and fluid-phase indices of inflammation: comparison of treatment with dithiothreitol vs phosphate-buffered saline. Eur Respir J1997;10:1336–40.
Louis R, Shute J, Goldring K, et al. The effect of processing on inflammatory markers in induced sputum. Eur Respir J1999;13:660–7.
Grebski E, Peterson C, Medici TC. Effect of physical and chemical methods of homogenization on inflammatory mediators in sputum of asthma patients. Chest2001;119:1521–5.
Anon. Definition and classification of chronic bronchitis for clinical and epidemiological purposes. A report to the Medical Research Council by their Committee on the Aetiology of Chronic Bronchitis. Lancet1965;i:775–9.
Morrison HM, Kramps JA, Burnett D, et al. Lung lavage fluid from patients with alpha 1-proteinase inhibitor deficiency or chronic obstructive bronchitis: anti-elastase function and cell profile. Clin Sci (Colch)1987;72:373–81.
Bland JM, Altman DG. Measuring agreement in method comparison studies. Stat Methods Med Res1999;8:135–60.
Wooten OJ, Dulfano MJ. Improved homogenization techniques for sputum cytology counts. Ann Allergy1978;41:150–4.
Mire-Sluis AR, Gaines-Das R, Thorpe R. Immunoassays for detecting cytokines: what are they really measuring? J Immunol Methods1995;186:157–60.
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Funding: I Woolhouse is funded by a Boehringer Clinical Fellowship.


Restricting the Command Line Could This Work ?
Discussion in 'other security issues & news' started by Ranget, May 4, 2012.
You could always restrict permissions by right clicking on CMD, selecting properties and then selecting the security tab. From there you can Allow or Deny permissions for system and your user account. If you deny, you can always revert back to allow if you need to.
You can lock down CMD through group policy.
In theory, setting restrictions for CMD should deny access to attacks accessing CMD as well.
I have it blocked with ProcessGuard, but other HIPS etc should be able to also.
But it's good in defending against Metasploit Like attacks ?
by Using Hips or group policy ?
I can't speak for how well it works on Win7 or 64 bit, but on XP and older I block user mode access to command line via classic HIPS. With Win 7 and 64 bit restricting how much kernel access HIPS can have, the control might not be as complete. The only way to know for sure is to test it.


Asden Development's taint ha befouled high office.
Criticised by judge – Legal Services Commissioner Paul Clauson.
Is Asden Developments the insolvency equivalent of an A-bomb? Its ex-director and her advisor were bankrupted, its first liquidator was admonished by the courts, and when the second liquidator tried to turn his predecessor's humiliation into recoveries and fees, he lost.
That was the initial fallout after Asden was placed into liquidation by its director back in late 2010. Now it seems even parties somewhat removed from ground zero are displaying signs of exposure.
According to the judgment of Queensland Supreme court Justice James Douglas in Nichols v Legal Services Commissioner  QSC 175 (15/3668) Douglas J 29 August 2017, Queensland's Legal Services Commissioner (LSC) has twice failed to adequately investigate or correctly rule on complaints about lawyers engaged by Asden's ex-director Melinda Nichols.
In case you're wondering, it's not actually clear whether Justice Douglas is referring to the current LSC, the former Corrective Services minister Paul Clauson or his predecessor, John Briton. The complaints that the LSC was found to have dealt with inadequately were initially submitted in 2013 but Clauson took over from Briton in 2o14.
That said, this judgment refers to more than one perceived lapse and there's no doubting the most recent took place on Clauson's watch, though it would appear that one of his senior investigators must also bear the burden of blame.
The allegation giving rise to the complaints to the LSC was made by Melinda Nichols's ex-father-in-law, George Nichols.
Justice James outlines how in late 2010 George Nichols transferred $270,000 to Asden in answer to Ms Nichols' request that she be provided with money to pay Asden's creditors.
The company was responsible for paying the suppliers to the Nichols' family's various property developments. Melinda Nichols was sole director. Simultaneously her ex-husband Phillip Nichols was suing her in the Family Court following the break up of their relationship. Before the year was done George Nichols' lawyers were demanding the $270,000 be repaid.
To assist her in dealing with the Family Court proceedings Ms Nichols engaged Doyle Keyworth Harris Family Lawyers. Between 8 February and 11 May 2011 $173,831.53 was transferred to her solicitors. Thereafter approximately $92,000 was transferred from a trust account to the firm for legal fees.
Unfortunately a Federal Magistrate presiding over the matrimonial proceedings later ruled that the $270,000 transferred to Asden had the character of Quistclose trust meaning the solicitors were not entitled to apply it to the payment of their fees. They were forced to withdraw from the matrimonial proceedings and in 2013 consented to judgment against them.
But George Nichols wasn't letting the matter rest there. On 9 August 2013 he lodged a complaint with the LSC in relation to the conduct of a specific lawyer working for Doyle Keyworth Harris in applying the relevant funds towards payment of legal fees when, it was alleged, the solicitor knew that the funds had been provided for the purposes of paying creditors of Asden.
An investigation was undertaken and in December 2014 the LSC advised George Nicholls that no further action would be taken. In April 2015 Mr Nichols applied to have that decision reviewed. A senior LSC investigator undertook that review and has apparently overlooked the Federal Magistrate's determination that the $270,000 was trust property.
Justice James quoted the LSC investigator as saying, " … in this matter, there has been no determination made by the Court as to whether or not the moneys paid to [the daughter-in-law] were 'impressed with a trust' or formed part of the 'matrimonial' property".
"Unfortunately, however, for her proper consideration of the issue, there had been a determination made by the Federal Magistrates Court of this very issue albeit after the judgment by consent had been entered against the solicitors," Justice James went on.
"In his decision Federal Magistrate Jarrett made it clear that he was satisfied that the funds paid to the daughter-in-law were paid for the specific purpose of paying the creditors of Asden.
The LSC then compounded its blunder by arguing that its investigator's conclusions were justified on the basis that the Federal Magistrate's reasons weren't available to her. Justice James was having none of it.
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Did you know that Sanitas clogs are the original clogs from 1907? When you buy a Sanita Original Fenja clog, you will get a red, dotted open clog made in PU leather.
The clog is made with a black PU (Polyurethane) sole, which together with the soft onSteam insole provides maximum comfort, shock absorption and good durability. The clogs are made of pure materials and is practical for multiple purposes; fashion as well as professional use.


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Browse: Home / 2005 / August / Comic Images to create Stargate card game
Comic Images to create Stargate card game
Products | August 2, 2005
Comic Images has acquired the license to create a collectible card game based on the hit Stargate franchise, ICv2 News is reporting. The company plans to unveil the game at Gen Con Indy in August, 2006.
It is not yet known when the series will hit the shelves, or whether it will include both SG-1 and Atlantis.
The New Jersey-based company has published trading card series based on such properties as 24, "Madagascar," "Shrek 2," and The Apprentice, and games for World Wrestling Entertainment. They are also currently developing collectible card games for "Godzilla" and "Conan."
Stargate was originally slated to have a trading card game published this past spring by Genio (story), but the company went out of business last fall amidst an avalanche of product returns and an egress of its top executives.
(Thanks to Eva B for the tip!)


Would you have waited for the 6+ if the 2015 launch rumor was true?
Discussion in 'iPhone' started by urkel, Sep 14, 2014.
The rumor going for months was that the 6 Plus was going to come out late (Early 2015). IF that happened then would you have skipped tr iPhone 6 and waited for the 6+?
Inventory issues seem to be real so I think a lot of people are going to see delays in their 6+ Preorders (including me). So to put things in perspective I'm thinking that at least I'm lucky it wasn't a 2015 release. Sure I have to wait 3wks but it would've been worse if it were a staggered release because I definitely would've got the 4.7" and then felt buyers remorse when the phone I "want" came out 6mo later.
No, I would have got the 6 and waited to get the Plus for the 6S Plus.
Yeah, mostly because I'm not seeing a huge difference between my 5c and the iPhone 6. I'm happy with the 5c, and so I would be content in waiting.
Nah, I'd have had a go at the Samsung Note 4 which is out next month I think. Been eyeing up Samsung phones all year after toying around with a friends Galaxy 5 inch something. Really sweet phone, but I hung in there as long as possible to see if Apple would pull through on the phablet thing.
Time waits on no one. I would've bought the 4.7" phone if the 5.5 wasn't ready and then gotten the 5.5" phone when it was ready.
I would have waited. I don't like to buy a phone more often than every two years. Of course that would probably change if Apple did major releases every year.
I've had my iphone 5 for almost 2 years and just had my sleep button fixed along with a new battery put in. I have it jail broken and it's still fast and does what I need it to do! I see no point in upgrading. I really like to get my bang for my buck! The new screen size doesn't make me too excited. (I have an iPad too.) What I would be excited about it a sapphire screen on the iphone 6s. That will be when I upgrade!!
I was pretty much ready to pull the trigger on the 4.7 iPhone 6 so I would have just jumped on it and later regretted it later when the 5.5 was out.
I would have gotten the 6 then the 6+ when released.
Yep. That was my plan.
No, my iPhone4 is really showing it's age. Actually, I only switched to the 6+ after seeing the announcement and assembling a mock-up.
No, I can't stand my galaxy. I prefer the plus, but not to the point where I would have waited months for it.
The way things are going, the 2015 launch may still be right.


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We talk the films of Martin Scorsese!
Rochelle and Lee are joined by original co-host Paul Anthony Nelson to talk about some big news regarding the future of the show.
They then dive into what is without a doubt the biggest episode of Hyphenates to date, as they look back at the films of the great filmmaker of the American New Wave, Martin Scorsese (08:35). Does Scorsese really lay a claim to the title of Greatest Of All Time? To figure it out, they're joined by a swathe of alumni from the show's past, who each pick a favourite film, scene, or moment to talk about.
Ozploitation legend Brian Trenchard-Smith and Dark Horizons editor Garth Franklin kick things off by talking about Scorsese's preoccupation with moral dilemmas, and his filmmaking pragmatism (16:27).
Critic Alexandrea Heller-Nicholas looks back at his early short film The Big Shave (19:52).
Actor Perri Cummings and filmmaker David Caesar talk Mean Streets (27:03).
Filmmaker and lecturer George Viscas discusses the realism and roots of Scorsese's gangland fixation (31:57).
Actor Pollyanna McIntosh talks Alice Doesn't Live Here Anymore (35:10).
Actor Cate Wolfe, film critic Ian Barr, writer Josh Nelson, and screenwriter Andrew Kevin Walker talk the seminal Taxi Driver (43:19).
Critic Glenn Dunks and film programmer Eloise Ross discuss New York, New York (54:50).
Filmmaker Briony Kidd examines Scorsese's work as the producer of other director's films (59:30).
Director Rohan Spong, comedian Chris Taylor, and critic Simon Miraudo look at The King of Comedy (1:08:39).
Film critic Scott Weinberg talks After Hours (1:20:34).
Journalist Guy Davis, director Kriv Stenders, and film critic Drew McWeeny look at the controversial The Last Temptation of Christ (1:25:42).
Critic Jeremy Smith looks at the difficulties and rehabilitation of Scorsese's 1980s period (1:32:17).
Actor Rhys Muldoon discusses Scorsese's cameo in After Hours (1:38:27).
Film critic Richard Gray and filmmaker Abe Forsythe pay tribute to the performances of Martin's mother, Catherine Scorsese (1:40:10).
Filmmaker Jon Hewitt, comedian Chris Taylor, presenter Marc Fennell, and critic Zak Hepburn look at Scorsese's obsession with food and garlic slicing (1:44:52).
Critic Blake Howard praises the closeups of Goodfellas (1:55:29).
Writer Emma Westwood looks at the impact of Goodfellas and Cape Fear (1:59:12).
Former Hi4H co-host So Mayer and author Mel Campbell discuss The Age of Innocence (2:07:07).
Critic Anthony Morris and exhibition registrar Sarah Caldwell talk Casino (2:13:58).
Writer Shannon Marinko salutes Scorsese's long-time collaborator, editor Thelma Schoonmaker (2:20:15).
Filmmaker Rhys Graham discusses Scorsese's seminal documentary series My Voyage to Italy (2:25:22).
Film reporter Alicia Malone and critic Hayley Inch pay tribute to Scorsese's film preservation and restoration work (2:30:05).
Filmmaker Tim Egan looks at Scorsese's concert film Shine a Light (2:37:20).
Festival programmer Thomas Caldwell and film critic Drew McWeeny talk Kundun (2:40:14).
Film critic Sarah Ward discusses Bringing Out the Dead (2:48:19).
Critic Stephen A Russell talks The Aviator (2:51:41).
Author Maria Lewis discusses being won over by Boardwalk Empire (2:55:17).
Entertainment reporter Giles Hardie talks The Audition (2:59:17).
Filmmaker Jennifer Reeder discusses The Departed (3:03:39).
Critics Alexandra Heller-Nicholas and Tom Clift talk Shutter Island (3:06:35).
Festival director Cerise Howard talks Hugo (3:12:12).
Comedian Tegan Higginbotham and director Brian Trenchard-Smith discuss The Wolf of Wall Street (3:21:08).
Actor Michael Ian Black and author Christos Tsiolkas talk Silence (3:25:43).
http://www.podtrac.com/pts/redirect.mp3/www.hellisforhyphenates.com/podcasts/Episode107-April2019.mp3
This entry was posted in podcasts and tagged a letter to elia, a personal journey with martin scorsese through american movies, abe forsythe, after hours, alexandra heller-nicholas, alice doesn't live here anymore, alicia malone, andrew kevin walker, anthony morris, blake howard, boxcar bertha, brian trenchard-smith, bringing out the dead, briony kidd, cape fear, casino, cate wolfe, cerise howard, chris taylor, christos tsiolkas, david caesar, drew mcweeny, eloise ross, emma westwood, feel like going home, gangs of new york, garth franklin, george harrison: living in the material world, george viscas, giles hardie, glenn dunks, goodfellas, guy davis, hayley inch, hugo, i call first, ian barr, it's not just you murray, italianamerican, jennifer reeder, jeremy smith, jon hewitt, josh nelson, kriv stenders, kundun, lady by the sea: the statue of liberty, life lessons, made in milan, marc fennell, maria lewis, martin scorsese, mean streets, mel campbell, michael ian black, mirror mirror, my voyage to italy, new york city... melting point, new york new york, new york stories, no direction home, perri cummings, pollyanna mcintosh, public speaking, raging bull, Remove term: american boy: a profile of steve prince american boy: a profile of steven prince, rhys graham, rhys muldoon, richard gray, rohan spong, sarah caldwell, sarah ward, scott weinberg, shannon marinko, shine a light, shutter island, silence, simon miraudo, so mayer, stephen a russell, street scenes, taxi driver, tegan higginbotham, the 50 year argument, the age of innocence, the audition, the aviator, the big shave, the color of money, the departed, the key to reserva, the king of comedy, the last temptation of christ, the last waltz, the neighborhood, the wolf of wall street, thomas caldwell, tim egan, tom clift, vesuvias vi, what's a nice girl like you doing in a place like this, who's that knocking at my door, zak hepburn on April 30, 2019 by The Hyphenates.
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1 thought on "Hell Is For Hyphenates – April 2019"
The Hyphenates Post author May 1, 2019 at 2:14 pm
Everyone On Scorsese: click to read this episode's show notes!
Plus this episode's announcement and the Martin Scorsese Cheat Sheet.


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History of Lottery Games
Lotteries are games that allow people to participate in a random draw. This form of gambling is popular in many parts of the world, and is a major source of money for public projects. There are over 100 countries worldwide where lottery games are played. They are popular in Canada, Mexico, and the United States, but also play a role in the Middle East and Asia Pacific.
The history of lotteries dates back to ancient China. In 205 BC, the Chinese Book of Songs mentioned a game of chance known as the "drawing of wood and lots." It is believed that the Han Dynasty used this game to finance important government projects.
The Roman Empire also used the lottery as a way to fund major government projects. Some records from the Roman era indicate that emperors gave away slaves and property in lotteries. As the popularity of lotteries grew, some criticized them as a form of exploitation of the poor.
After the French and Indian War, lotteries were used to raise funds for local militias, bridges, libraries, and schools. Several colonies in North America also had their own lotteries, and some of the money was used to finance local colleges. During the early 18th century, lotteries were the primary funding source for religious congregations in Europe and the US.
By the 19th century, private lotteries were legalized in the US. Some bishops complained that lotteries exploited the poor, and others favored them. Others argued that lotteries were a form of hidden tax. However, the popularity of lotteries grew in the 18th and 19th centuries, and they became popular entertainment at dinner parties.
The first documented European lottery was held during the Roman Empire. It was a source of amusement at Saturnalian revels. Originally, lotteries were organized for the wealthy by wealthy noblemen, who distributed tickets to guests at their dinner parties. Eventually, the lottery grew in popularity and became the main source of revenue for many towns and cities.
The United Kingdom and the United States also had private lotteries. They were considered illegal in most of Europe until the late 18th and early 19th centuries, but the popularity of lotteries grew. Among other reasons, lotteries were viewed as an unfair method of taxation, and some jurisdictions banned them.
Many states in the US used lotteries to raise funds for public projects. These included colleges and universities, local hospitals, and roads. During the 1740s, Princeton and Columbia Universities were financed by lotteries. Later, the University of Pennsylvania was financed by the Academy Lottery in 1755.
As the popularity of lotteries grew, they became more and more popular in the United States, but many people were not willing to take part in such activities. The United States had over 200 lotteries between 1744 and 1776. Throughout that time, some of the profits were given to the state, but the majority was spent on public projects.
The lottery industry in the United States grew after World War II, and by 1950 it was selling over $71 billion a year. Until then, it was considered a scam, and some jurisdictions outlawed it. Despite these problems, the lottery has continued to grow, and is one of the most profitable types of gambling in the world.
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