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Business crime and fraud
Cartel or Antitrust
Cash and asset seizure & forfeiture
Corporate manslaughter/health and safety
Dawn raids and searches
Export controls and trade controls
FCA investigations including insider dealing and market abuse
Food safety/environmental health
Police investigations and general defence
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Corker Binning's 'top niche practice' is praised as being 'on a different level'. David Corker 'has the skill and tact to deal with difficult negotiations', and Peter Binning is an 'outstanding tactician' with 'excellent client skills and judgement'. 'Rising star' Andrew Smith represented a former company director in relation to Operation Tabernula. Robert Brown is also recommended, for his 'wealth of experience'.
"They're good at coming up with solutions and strategies for thinking outside the box. They've got strength in depth."
Peter Binning stands out in the UK market for his exceptional work dealing with financial crime matters and related investigation on behalf of both corporates and individuals.
Who's Who Legal: Investigations 2018
"A consummate professional and the complete package."
Peter Binning is "hugely knowledgeable".
Jessica Parker is a well-respected name among peers and clients alike, who praise her expert handling of criminal regulatory matters.
The lawyers are noted for their "extensive high net worth experience."
Chambers HNW 2018
"He is tenacious in representing clients' interests, but does so in an intelligent and extremely effective way."
"Fantastic tactician."
"She is very cool and collected," as well as being "a model of very good client care," known for "rolling up her sleeves and immersing herself in the case."
Peter Binning and Claire Cross are 'brilliant at the interface of insider dealing and market abuse and are able to run rings round the regulator'.
Extradition specialist Edward Grange is praised by sources as "utterly dedicated and incredibly hard-working."
Andrew Smith "has a wisdom beyond his years. He is very thoughtful. He acts on high-profile cases and keeps his cool in any situation."
David Corker has an excellent reputation for advising on cartel defence as part of his white-collar practice.
David Corker is 'a fantastic technical lawyer with extensive experience in the financial services area'.
The Legal 500 UK 2017
Peter Binning is "extraordinarily smooth and unflappable".
"David is quite a cerebral lawyer - he's sort of a lawyer's lawyer. He really understands the law and is quite creative; he spots areas of the law to investigate and challenge," remarks one interviewee.
They are very good and fearless, which is to their credit.
Jessica Parker is "incredibly talented".
Jessica Parker is highlighted for her "phenomenally hard-working" approach and she is "outstanding, pragmatic and personable."
"His knowledge of the law is unparalleled and he has a wealth of hands-on experience."
Founder David Corker is held in high regard. "He is as top-tier as they come", affirms one respondent.
Who's Who Legal 2016
A luminary of British and Russian law, [Robert] Brown has been instructed across a striking diversity of cases.
Spear's 500
"Really solid knowledge of the law and steely determination."
"They've got a real variety of skills between them. They are one of very few firms that can deal with difficult extradition cases that raise political issues."
"The firm has so many partners who are experts in extradition, it gives the team a lot of expertise and experience in preparing cases."
The "absolutely phenomenal" Robert Brown is a criminal defence specialist who is "full of ideas, utterly committed to his clients, realistic in his advice and leaves no stone unturned in preparation."
A peer says: "I would be very comfortable working alongside him or sending a case to him, I would know that it would be looked after. He's very, very smart and clearly does a great job for his clients."
David Corker "has led some big shifts in thinking".
Andrew Smith "is very responsive and very energetic in the way he approaches a problem".
Sources say department head Peter Binning is "very calm and focused in a crisis." He concentrates on regulatory and fraud litigation, and has substantial experience in defending professionals in domestic and international investigations.
"He is a standout because he has the ability to speak to clients in a language they understand."
Sources speak of Peter's "stellar reputation," and describe him as "a real doyen of the corporate criminal area and a senior figure with a huge amount of experience."
David Corker is "absolutely fantastic" according to sources, who particularly commend his impressive work on financial crime and cartel investigations.
[Edward Grange] is always creative and imaginative in his approach and always thinking about new angles for cases. He is a really respected solicitor.
Andrew Smith is highlighted as "extremely clever and tactical."
Peter Binning is recommended by peers for his significant experience in complex extradition matters. Sources say: "He is thorough, intelligent and very skilled."
"Highly skilled tactician with a wealth of experience."
Andrew Smith is 'an excellent lawyer, extremely bright and very efficient and practical in dealing with disciplinary and regulatory issues'.
"She is a class act: measured, practical and highly intelligent."
"They are very informed about this area and understand what it takes to win a case."
'High-quality boutique' Corker Binning is 'a leading firm in this practice area, and is involved in many of the most serious and high-profile cases'.
Peter Binning is 'an outstanding presence in the field of extradition and multi-jurisdictional fraud'.
"They move quickly and with an unprecedented thoroughness."
"The firm is highly efficient, client-conscious, and you just get a great service and great back-up."
"They give their clients a top-notch service and are prepared to go the extra mile."
"They know what they are talking about, they have good ideas and they take the lead."
David Corker 'has the skill and tact to deal with difficult negotiations'.
David Corker "is a very highly respected practitioner."
"Extremely adept and experienced practitioner."
Andrew Smith is well-regarded in Chambers, and notes that he "strategises very well and makes one feel very comfortable with his advice."
Claire Cross 'knows every document in the case'.
Corker Binning has 'huge expertise and experience in advising senior individuals in high-profile, complex and sensitive criminal investigations'.
"Incredibly cerebral and a great strategic thinker when needed for complex criminal cases."
Andrew Smith is 'fiercely intelligent, has great judgement and an established reputation'.
The 'extremely talented' Robert Brown 'always sees the bigger picture'.
Jessica Parker "has complete mastery of her cases and excellent client-handling skills."
David Corker is highlighted in Chambers as "very personally interested in the law," as well as being "sensible, assured and thoughtful" when providing advice.
Gemma Tombs offers expertise in a wide variety of criminal and regulatory matters.
Peter Binning is an 'outstanding tactician' with 'excellent client skills and judgement'.
Jessica Parker is "very hard working and committed to her clients."
Robert Brown is "the master of client management and a pleasure to deal with."
A heavy-hitting firm for extradition. They are a private client firm that carry over standards to legal aid work.
They are highly efficient and client-conscious - you just get a great service there.
David Corker is very highly regarded and able to think laterally, often coming up with surprising solutions to problems.
Peter Binning is right at the top of financial crime.
'First-rate' Corker Binning has 'established an excellent reputation for its quality of work in white-collar crime'.
Peter Binning is 'a major player who is supported by a strong team of junior colleagues'.
Sources find it "enormously valuable" that she is "not afraid to speak her mind and take a dissenting view."
Peter Binning is praised for "In that particular field of representing senior corporate individuals, he is clever, has great judgement and is a really great tactician"
"One of the major players in this field."
The Spear's 500 2019
Peter Binning is well versed in large-scale cartel matters. Sources highlight his pragmatic, commercially aware approach.
"One of the firms at the forefront of the market representing individuals and companies. They are a compact, energetic, entrepreneurial firm who know what they're doing and have good partners."
Corker Binning is 'fast becoming the go-to firm for interesting and complicated criminal cases, particularly those with an international dimension'.
Andrew Smith is recognised as a formidable litigator for white-collar and regulatory matters, on an international scale. Sources praise him as "a very clever practitioner who provides sensible advice" and "a go-to name for individuals who need separate advice in a corporate investigation"
"Very proactive in regard to anticipating their clients' needs."
Jessica Parker "is a class act: measured, practical and highly intelligent."
Jessica Parker "is very cool and collected".
Jessica Parker has 'an impressive capacity to rapidly absorb large volumes of material and identify the key issues'.
Regarded as 'one of the top niche crime firms', Corker Binning offers a service that is 'second to none'. The 'extremely talented' practice head Robert Brown, who 'always sees the bigger picture', acted for a number of clients on the Leveson Inquiry.
David Corker is a seasoned criminal defence partner with extensive experience in domestic and cross-border fraud matters. Sources say he is "very highly regarded and able to think laterally, often coming up with surprising solutions to problems."
"He has a rare combination of strategic 'big picture' instincts with a very detailed knowledge and understanding of the black-letter law."
"The cases that Corker Binning do are exceptionally complex and high value."
They are up to date on the law, they are agreeable and they are responsive. When there is an issue to be addressed, they do it in a timely way and in expert fashion.
Claire Cross is 'a bright new star'.
Founding partner Peter Binning, our reigning Business Crime Lawyer of the Year, is celebrated among peers and clients alike, who take note of his "immense experience" and "impeccable judgement".
A source noted the team is made up of "highly intelligent, sensible and dedicated people, who are also down-to-earth and approachable."
The 'extremely talented' [criminal] practice head Robert Brown, who 'always sees the bigger picture', acted for a number of clients on the Leveson Inquiry
Andrew Smith is praised for his 'great mind' and academic approach. Sources comment that 'he has a very measured and reassuring way about him, and the quality of his work is fantastic.' He is also recognised for his strengths in extradition and international crime cases.
Robert Brown is recognised for his first-rate work in the field.
"Real rigour is applied to the strengths and weaknesses of the case and sensible advice is always given. The firm's client focus is second to none."
Outstanding practitioner Robert Brown is characterised as reassuring and knowledgeable. Commentators report that "he has a great reputation for snuffing out prosecutions before they even begin. He possesses mature judgement and vast experience in all types of criminal cases."
The crime team is led by 'down to earth and pragmatic' Robert Brown, he is supported by the 'astoundingly good, dedicated, hugely experienced, and extremely bright' Andrew Smith and Edward Grange.
"His ability to analyse cases and work out a route to achieve success is remarkable."
The firm is "very attentive to the needs of the client, very thorough and responsive."
"A superb and very academic lawyer" who is "a key name" in the market.
Who's Who Legal: Business Crime Defence 2018
"Very intelligent and works extremely hard."
"David's very much detail-focused, so he's going to reassure a client that he's thought of absolutely everything," says a source.
Peter Binning is celebrated in Chambers HNW as: "He is excellent. He is very clever and a real thinker about legal conundrums. He is proactive, innovative and very professional."
Peter Binning is recommended in Chambers HNW as: "I find him easy to get on with, very personable," reports an observer, adding: "He is very decent and compassionate with individuals in serious trouble. I'm a great fan."
Sources say David Corker is 'the first port of call for individual representation in a corporate crime context.' He has significant experience in cases involving allegations of fraud and corruption, as well as cartel investigations.
"Outstanding, very able and a pleasure to work alongside."
Jessica Parker is 'a dynamic and bright individual who works well with clients'.
The level of preparation is really fantastic. They will look into every possible outcome and research issues, and explain them to the client in a way in which is incomparable.
"He is very highly specialised in business crime work."
Edward Grange is viewed as a leading extradition practitioner. Sources say: "He cares deeply about his clients, he is passionate about the work he does and he is incredibly knowledgeable."
I think they're a great firm for [POCA Work & Asset Forfeiture]. Very boutique-like and dedicated to their clients.
"It's a team effort there. From top to bottom and at every level, they are on top of their game."
Peter Binning is 'a seasoned expert, particularly in the field of international white-collar crime'.
Edward Grange is 'fantastic with clients and meticulous in his preparation'.
Peter Binning is "very good at the strategic aspects and knows how to prepare and marshal evidence for the best forensic effect."
They provide high-quality advice. They are criminal lawyers with a good commercial sense.
"They very much have a good reputation," says an interviewee, adding: "I think that one of the features of this sort of high net worth work in the criminal arena is that the clients are very much looking for someone who is discreet and will shield them from the more unpleasant side of criminal law, and will provide a service which has an eye to the expectations and needs of high net worth clients - I would definitely say that they manage that well."
Andrew Smith has a broad international practice, encompassing extradition and crime. Peers note that he is 'very bright, quick-thinking and ideal with clients: he is a star of the future.'
"Corker Binning are top of the list of go-to firms to represent suspects in large, high-profile SFO criminal investigations."
"Peter has been involved in many of the largest and highest-profile commercial investigations."
Robert Brown is 'calm, authoritative and knowledgeable'.
"An incredibly knowledgeable figure who knows exactly how to deal with the police."
"She is sharp, diligent and much loved by her clients."
Peter Binning is a "highly experienced all-rounder".
At Corker Binning, Andrew Smith 'is a first-class lawyer, and very user friendly'; he leads the [professional discipline] team, which specialises in financial crime.
Jessica Parker is an acute tactical thinker who always keeps the interests and sensitivities of her clients at the forefront of her mind.
Peter Binning has a wealth of experience in extradition law. Peers describe him as a 'heavy hitter' and 'a consumate international criminal lawyers'. He is also praised for his client care and judgement.
Andrew Smith is "extremely clever, realistic and tactical".
"They are one of the premier extradition firms and their solicitors are without doubt leaders in their field - they are all intelligent, hard-working and pragmatic."
[Jessica Parker] is very passionate about her cases, she is realistic, she understands the problems that arise and she is very talented.
David Corker is "a fantastic criminal defence lawyer used to operating in a corporate space."
Corker Binning is 'a very strong law firm and a pleasure to deal with'.
What the firm lacks in size, it more than makes up for in the experience and expertise of its practitioners, who cover all the key areas of financial and regulatory enforcement. Corker Binning regularly represents large corporations and high-profile individuals in FCA and SFO investigations and prosecutions and clients are impressed by the "sensational level of support on offer".
Who's Who Legal 100 2016
Peter Binning is highlighted in Chambers HNW 2016, who is recommended as: "He has exceptional judgement, particularly when defending individuals in big cases. He's an expert tactician and is very easy to work with."
"They're very well respected for their defence work. They provide an approachable boutique service, while also having the flexibility to respond quickly to changing circumstances and the capability to deal with large and complex investigations and prosecutions."
"They are realistic and have their clients' best interests at heart. They are very committed to the work they do and also rigorous."
"Niche and extremely powerful in their field and in everything they do. I think they have some of the leading people."
He has a "great knowledge of international law."
At Corker Binning, Andrew Smith 'is a first-class lawyer, and very user friendly'.
Andrew Smith is "a very accomplished and knowledgeable extradition practitioner." He is recommended for his abilities in politically sensitive matters involving high-profile figures.
"A top-flight firm with the highest standards."
Andrew Smith is "very erudite and savvy".
"Peter is very personable, he's got a warm personality and he's very good with clients," reports an interviewee, adding that "he's very able and an extremely experienced lawyer. He has a wealth of experience."
"A serious firm focused on providing the best advice to clients and which is not afraid to confront the difficult issues."
[Robert Brown] is someone who understands not only law but how it works with business. You feel like you are in good hands and he has a phenomenal track record.
"He takes a client-focused approach" and is "exceptionally personable"
Peter Binning is well-regarded as "very astute - he really identifies legal issues and gives sound advice."
David's innovative in his approach to his cases. He tends to have different ways or new angles to offer on a particular situation.
"They have a high density of the leading players - both David Corker and Peter Binning are very much at the top of the tree."
Peter Binning is 'the godfather of business crime'.
"He has seen both sides and understands what is achievable."
Andrew Smith is described as "a very good technical lawyer" with a "fearsome intellect."
Peter Binning "has that tactical nous as well as the bedside manner – it's a killer combination."
Andrew Smith is "a real pleasure to deal with."
"From the outset they are realistic with their clients and tactically they are very astute."
Corker Binning is "one of the pre-eminent firms in this area at the moment."
Jessica Parker demonstrates "a model of very good client care, rolling up her sleeves and immersing herself in the case."
Edward Grange is "remarkably thorough, inventive and understands clients", he is "everything you'd want in a solicitor."
"An incredibly brilliant lawyer."
Peter Binning has a thriving criminal defence and regulatory practice, regularly providing counsel on complex corruption, revenue fraud and sanctions matters. Observers note: "He has exceptional judgement, particularly when defending individuals in big cases. He's an expert tactician and is very easy to work with."
"He is experienced, goes the extra mile and really engages in a case."
"First-class operator," Edward Grange, comes highly recommended as a "an encyclopaedia of extradition knowledge."
'Pre-eminent boutique' Corker Binning acts in matters of possession and supply of drugs, grievous bodily harm, contempt of court, sexual offences, manslaughter, murder and extradition
"They are among the top few 'big hitter' firms for private crime, and are among the few I would recommend to anyone who needed representation. They give their clients a top-notch service and are prepared to go the extra mile."
Jessica Parker is praised as "clever, efficient and very good at looking after the client's emotional wellbeing."
Andrew Smith frequently advises on white-collar crime and regulatory issues, including SFO, FCA and HMRC prosecutions. He has notable experience in representing individuals in complex extradition cases.
They have got a fantastically strong team.
Robert Brown is celebrated as an "absolutely first-class solicitor" with a "phenomenal criminal practice."
"Bags of experience and he provides great insight into the criminal elements of international fraud cases."
"In financial crime their partners are very, very highly regarded."
He has a "good head for detail."
"They're admirable for being prepared to say 'we don't do everything, but we are completely expert in the things that we do.'"
"They are uniformly easy to work with and a very energetic and smart collection of individuals."
David Corker is 'an innovative thinker, takes nothing for granted, exceptionally perspicacious tactician, modest and very highly-regarded by other lawyers'.
"I really rate them. They are clever, efficient and they work collaboratively."
"The firm has a meticulous approach and in this field of work they provide the highest standard of service to the client."
"David is brilliant on forensic and disclosure issues."
Corker Binning has 'a well-deserved reputation for excellence in the fraud and white-collar crime space', and 'combines hard work, commitment and excellent judgement to provide a through and efficient service'
The team 'brings a strong wealth of experience in dealing with criminal litigation into the complex world of fraud' and the 'talented lawyers demonstrate the highest professional standards'.
"Calm, client-focused and cool-headed."
Jessica is described as "the complete package: bright, decisive and responsive."
Edward Grange is celebrated as "excellent with clients and extremely hard-working," highlighting his expert advocacy skills and "unique insight into how extradition cases work."
The 'exceptionally strong' and 'straightforward' practice at Corker Binning continues to act for corporate and individual clients in the financial sector, with strengths in regulatory litigation, criminal fraud, and corporate crime.
Corker Binning is "a very strong firm in its field."
Andrew Smith is acclaimed in Chambers as "a huge legal brain and a thoroughly nice guy to boot."
Peter Binning is 'exceptional in everything he does'.
[Robert Brown is] a Rolls-Royce solicitor, providing Rolls-Royce services.
As part of Corker Binning's fraud and regulatory practice, our export control lawyers have substantial experience of advising and representing companies and individuals on import/export and other trade control investigations. We have particular expertise where there is a risk of criminal offences being committed or where a criminal investigation has already started. Our export control lawyers have acted in many of the landmark export control and trade control prosecutions listed on the website of the Export Control Joint Unit (ECJU), which is now part of the Department for International Trade. We have also had considerable success in advising companies and individuals on the merits of making voluntary disclosures to Her Majesty's Revenue and Customs (HMRC) with the aim of avoiding a criminal prosecution and negotiating a civil settlement (sometimes called a "compound penalty") instead.
We have dealt with investigations and prosecutions relating to a huge variety of military goods (including body armour, fighter jet and tank components, weapons and ammunition) and dual-use goods (including cryptographic software, aviation parts, cleaning components and chemicals) exported to a large number of destinations (including across the EU, as well as more sensitive destinations such as Iran, Iraq, Israel, Sri Lanka, Peru, Venezuela, Nigeria and, Senegal). Our export control lawyers are well versed in the issues that typically arise in such prosecutions:
the technicalities of the UK's licensing system and the operation of the Export Control Organisation (ECO), including SPIRE
seizures of goods carried out at the UK's borders by HMRC and UK Border Force (UKBF)
raids of a company's premises carried out by HMRC and/or the UK Border Force (UKBF)
the evidence that the Crown Prosecution Service (CPS) rely on to demonstrate an intention to evade the UK's export control or trade control regimes.
For a detailed overview of these issues and the offences that are typically investigated, see our blog here. Our export control and trade lawyers have strong links with experts in this field, including former managers from the Government's export control department and independent consultants who assisted in drafting the relevant UK and EU law regulating the international trade in restricted goods. Expert evidence is often required in criminal cases where issues about the true nature of the goods arise, e.g. whether the goods are on the UK's military list, whether they are dual-use, and the potential end uses for the goods. We are as familiar with the UK's trade control regime (which restricts "brokering" the transfer of goods between two "third countries") as we are with the UK's domestic export control regime.
Our experience is not limited to export control and trade control cases governed by UK law. Any cross-border transfer of goods can trigger obligations under international law or EU law. Working with law firms in the US and Europe, we have advised numerous companies and individuals on the combined effect of these laws and how businesses can make themselves compliant.
Our export and trade controls lawyers have recently advised on the following matters:
A household name business regarding its obligations under the Convention on the International Trade in Endangered Species of Fauna and Flora and the associated EU legislation governing imports of restricted goods into the EU.
A UK company which successfully negotiated a £1,000 compound penalty as an alternative to being prosecuted for alleged breaches of Open General Export Licences arising from the sale of armoured vehicle components within the EU.
Two listed UK companies in the aviation sector seeking advice on whether their export business was being conducted in compliance with UK/EU law.
Two multinational law firms which made voluntary disclosures concerning their unlicensed export of cryptographic software to sensitive destinations including China.
An individual who successfully negotiated a £5,000 compound penalty as an alternative to bring prosecuted for brokering ammunition from Bosnia to Saudi Arabia.
A European multi-national company engaged in the sale of machinery to Iran containing an element of US manufactured software triggering potential offences under US law.
← Environmental crime
→ Extradition
Andrew Smith comments in WorldECR on export and trade controls
Andrew Smith's comments re criminal prosecutions for breaches of export and trade controls published in WorldECR
CAEC report critical of government's record on arms controls
+44 (0)20 7353 6000 (24 hours)
This Thursday at 6.30pm, Partner @JessicaParkerCB is speaking at @FemFraudForum, hosted at @RPCLaw, where she will… twitter.com/i/web/status/12192…
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Role for Caspase-Mediated Cleavage of Rad51 in Induction of Apoptosis
Tag: CS-088
Neonatal encephalopathy (NE) is a leading reason behind childhood loss of
September 10, 2018 September 10, 2018 Hazel Steward	Leave a comment
Neonatal encephalopathy (NE) is a leading reason behind childhood loss of life and disability in term infants. on M1-like and M2-like phenotype using qRT-PCR and Traditional western blotting, like the requirement for the current presence of CS-088 p53 or HSP-70 in these results. We also evaluated phagocytosis and the consequences of PFT- on genes within metabolic pathways linked to phenotype. We observed that PFT- robustly decreased the M1-like (lipopolysaccharide, LPS-induced) BV2 response, spared the LPS-induced phagocytic capability of BV2 and acquired no influence on the genes linked to metabolism which results on phenotype had been partially dependent on the presence of HSP-70 but not p53. This study demonstrates that this neuroprotective effects of PFT- in HI-induced NE CS-088 may include an anti-inflammatory effect on microglia and adds to the evidence that this drug might be of clinical interest for the treatment of NE. (glyceraldehyde 3-phosphate dehydrogenase). Analyses were performed with the Bio-Rad CFX Manager 2.1 software. Table 1 Protein levels in media from BV2 treated with LPS with and without PFT- for 10 min). Cytokine CS-088 and chemokine levels in the microglial media were measured using a Bio-Plex 200 with a 96-well magnetic plate assay according to the manufacturer's instructions (Bio-Rad). Cytokines and chemokines measured included IL-1, IL-1, IL-2, IL-6, IL-10, IL-12 (p70), IL-13, G-CSF, GM-CSF, IFN, TNF, CXCL1 (KC), CCL2 (MCP-1), and CCL5 (RANTES). All samples were run in duplicate and data were analyzed with the Bio-Plex Manager software. Cell Viability (Mitochondrial Activity) Assay Microglial viability was quantified using MTT [3-(4,5-dimethylthiazol-2-yl-)-2,5-diphenyl-2H-tetrazolium bromide; Sigma]. In this assay MTT, a tetrazolium dye, is usually bioreduced by the mitochondria into a formazan product that is insoluble in tissue culture medium [33]. In brief, MTT was added to a final concentration of 250 g/ml to cells at numerous time points following treatment with PBS, LPS or IL-4 with or without PFT-. After 30 min, formazan was dissolved in DMSO and the absorbance was measured at 490 nm using a spectrophotometer (Glomax Multi+; Promega, UK). Phagocytosis Assay Phagocytosis of fluorescently labelled particles by BV2 was assessed using the Vybrant phagocytosis assay (V-6694; Invitrogen) according to the manufacturer's instructions. In brief, 50,000 cells were plated in 48-well plates and after 16 h of incubation with LPS with and without PFT-, the medium was changed to serum-free media containing the recommended suspension of bioparticles. Cells were incubated for 5 h before the particle-containing media was Rabbit Polyclonal to ZNF225 removed, washed twice with serum free media and incubated with a solution of trypan blue for 1 min to quench extracellular fluorescence and 1 ml of serum-containing media added to each well. The absorbance of each well (including cell-free, bead-free and media-free controls) was read. To adjust for cell density, following reading of the plate the cells were used in an MTT assay. The cells were also visually inspected for fluorescence and images were acquired on an EVOS? FL cell imaging microscope (Life Technologies, UK). Gene Silencing Experiments Synthetic RNA duplexes for p53 (AM16708, with siRNA experienced no effect on the expression of COX2 protein by BV2 in response to VEH or LPS in the absence of PFT- (data not shown). The efficacy of PFT- in reducing the LPS-induced COX2 expression was not affected by silencing p53, and the same significant dose-dependent decrease in COX2 was observed (fig. ?(fig.7a).7a). Activation with LPS was associated with a decrease in p53 protein; this was reduced by approximately 50% with siRNA against p53 (fig. 7b, c). Open in a separate windows Fig. 7 a Silencing of p53 expression has no effect on the how PFT- reduces LPS-induced COX2 protein expression CS-088 (quantified by Western blot). b Validation of the effects of p53 siRNA on p53 protein expression. c A representative Western blot. Mean SEM (n = 5). * p 0.05 (one-way ANOVA for effect of LPS and siRNA on expression of p53 protein); *** p 0.001. Silencing HSP-70 ( em Hspa1a /em ) gene manifestation decreased the effectiveness of PFT- to reduce COX2 manifestation from LPS-stimulated BV2 (fig. ?(fig.8a).8a). We mentioned the dose-dependent reduction in COX2 was not observed in HSP-70 siRNA-treated BV2. Activation with LPS was associated with a decrease in HSP-70 protein; this was reduced by approximately 50% with siRNA against HSP-70 (fig. 8b, c). Neither silencing of p53 nor HSP-70 experienced any significant effect on cell health as measured by MTT assay (data not shown). Open.
Purpose This study evaluated the predictive performance of a combination of
November 25, 2017 November 25, 2017 Hazel Steward	Leave a comment
Purpose This study evaluated the predictive performance of a combination of self-report questionnaires, salivary hemoglobin levels, and age as a noninvasive screening method for periodontitis. predicting prevalence of CPI scores of 3C4 and 4 were 0.63 and 0.67, respectively (with sensitivity values of 71% and 60% and specificity values of 56% and 72%, respectively). Two unique units of five questions were associated with CPI scores of 3C4 and 4, with AUROCs of 0.73 and 0.71, sensitivity values of 76% and 66%, and specificity values of 63% and 69%. The combined model incorporating both variables and age showed the best predictive overall performance, with AUROCs of 0.78 and 0.76, sensitivity values of 71% and 65%, and specificity values of 68% and 77% for CPI scores of 3C4 and 4, respectively. Conclusions The combination of salivary hemoglobin levels and self-report questionnaires was shown to be a valuable testing method for detecting periodontitis. test. Next, the validity of salivary hemoglobin levels only (Model 1) and selected questions only (Model 2) in predicting CS-088 the prevalence CS-088 of periodontitis diagnosed by a CPI score of 3C4 or 4 was evaluated, in order to establish a baseline for evaluating the utility of a combined method. Binary logistic regression analyses were performed to confirm the cutoff point and the predictive overall performance of each model. Next, receiver operating characteristic (ROC) curves were constructed and the area under the ROC curve (AUROC), sensitivity, and specificity were calculated. Finally, this study evaluated the validity of a combined model (Model 3), which incorporated salivary hemoglobin levels over the cutoff point confirmed in Model 1 and the questions identified as significant predictors in Model 2, as well as age, to predict the prevalence of CPI scores of 3C4 and 4. All AUROC values were also compared. The maximum point that this sum of the sensitivity and specificity values was established as the cutoff point. All statistical analyses were performed using SPSS 20.0 (IBM Corp., Armonk, NY, USA) and STATA 13.0 (Stata Corp., College Station, TX, USA). P-values <0.05 were considered to indicate statistical significance. RESULTS The general characteristics of the 202 participants are offered in Table 1. A total of 79.7% of the patients were CS-088 diagnosed with CPI scores of 3C4 (24 to 79 years old, mean age=54.3 years), and 46.5% were diagnosed with a CPI score of 4 (24 to 78 years old, mean age=53.1 years). As the age of the participants increased from 20 years to 50 years, the number of periodontitis patients also increased. Overall, more patients were diagnosed with a CPI score of 4 than with a CPI score of 3. The distribution of scores according to sex was relatively equivalent. However, there were more CPI 4 patients than CPI 3 patients among males, whereas both categories of periodontitis were similarly represented among females. Of the participants, 25.7% had systemic disease. Hypertension was the most common systemic disease, followed by diabetes. Table 1 Distributions of study participants by periodontitis category and selected demographic characteristics The salivary hemoglobin levels of the participants were grouped by CPI score (Table 2). The distribution of salivary hemoglobin levels significantly varied among the five CPI groups (P<0.001). The median salivary hemoglobin levels were least expensive Rabbit Polyclonal to TNFAIP8L2 in the CPI 0 group, at 0.29 g/mL (range, 0.11C15.44 g/mL), and highest in the CPI 4 group, at 1.45 g/mL (range, 0C156.24 g/mL). However, the median salivary hemoglobin levels did not uniformly increase as the CPI score increased, because the median score in the CPI 2 group was higher than that of both the CPI 1 and 3 groups. When the CPI groups were divided into two subgroups according to the severity of periodontitis, significant differences were found in the hemoglobin levels between the groups with and without periodontitis as defined by a CPI score of at least 3 (P=0.011), and between the groups with and without CS-088 a CPI score of 4 (P<0.001). Table 2 Distributions of salivary hemoglobin levels by CPI score The correlations between the prevalence of each level of periodontitis severity (CPI scores of 3C4 and 4) and each question are shown in Table 3. The questions were completed by all participants. The following five questions showed significant associations with a CPI score of 3C4: Q1 (the presence of gum disease), Q2 (subjective rating of gum/teeth health), Q4 (the presence of a loose tooth not caused by an injury), Q5 (presence of lost bone), and Q7 (dental floss use). A CPI score of 4 was significantly associated with the following questions: CS-088 Q1, Q2, Q4, Q5, and Q9 (smoking habits) (P<0.05). Thus, these two slightly distinct units of questions were used to predict CPI scores of 3C4 and 4, respectively. Table 3 Distributions of responses to questions and their correlations with periodontitis Table 4 and Physique 1 present the validity of salivary hemoglobin levels (Model 1), self-report questions (Model 2), and a.
Acetylcholine ??7 Nicotinic Receptors
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Serotonin (5-ht1E) Receptors
Sigma1 Receptors
Signal Transducers and Activators of Transcription
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Gastric cancer is the third many common reason behind cancer-related death.
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redpajama_set_name: RedPajamaCommonCrawl


text:
Recreio dos Bandeirantes  és un barri noble de la Zona Oest de la ciutat de Rio de Janeiro. Es un dels barris més joves de la ciutat, localitzat a la zona administrativa de Barra da Tijuca. Té una superfície de 30,655 km² i una població de 82.240 habitants, coneguda per l'ambientalisme, i platges per la pràctica d'esports aquàtics.

Limita a l'est amb Barra da Tijuca, al nord amb Camorim, Vargem Pequena y Vargem Grande, a l'oest amb Barra de Guaratiba, Grumari i Guaratiba, i al sud amb l'Oceà Atlàntic.

Característiques
El barri del Recreio és relativament nou, ocupat principalment per residents de la classe mitjana i alta. Es troba fora dels principals circuits turístics de la ciutat de Rio de Janeiro, encara que té boniques platges per banyar-se i per al surf, així com grans parcs i espais verds lligats a la preservació mediambiental. El barri és també continuació de Barra da Tijuca.

El Recreio és un barri amb un predomini de cases i edificis baixos en el passeig situat davant del mar. Les regles de construcció han estat concebudes per a no cometre els mateixos errors de la zona sud de la ciutat o del barri veí de Barra da Tijuca.

El barri ha estat planificat en acord amb les idees dominants de l'urbanisme i de l'arquitectura moderna del , amb poc component humà, posant el cotxe al primer pla. Així, és gairebé impossible de viure-hi en certes parts sense cotxe. El problema més gros del barri, és la dificultat de desplaçament cap al centre de la ciutat.

El Recreio és també un barri que ha sabut conservar una bona qualitat de vida, davant del progrés desenfrenat dels altres barris de la ciutat.

Història del barri
La zona oest de Rio de Janeiro era ocupada per l'agricultura des de la meitat del , sota la forma de concessions de terres donades als portuguesos després de la fundació de la ciutat. Però Barra da Tijuca i Recreio van ser relegades a un segon pla a causa de les immenses llacunes, manglars i platges que hi havia. L'any 1710, el comandant de marina Jean-François Duclerc, en ocasió d'una expedició organitzada des del port francès de Brest per apoderar-se de la ciutat del Rio de Janeiro, arriba a les platges del barri, llavors sense habitants. L'expedició tenia sis naus i 1.200 homes. Tanmateix, els portuguesos en van ser advertits a temps i l'operació va fracassar.

Es va comencar urbanitzar la zona a principi del . Aleshores, el terreny que avui correspon al Recreio pertanyia a la Banca de Crédito Móvel que el va dividir en dues parcel·les, que tenien un molt baix valor comercial respecte a altres barris de la ciutat. L'estatunidenc Joseph Finch Weslley en va comprar una els anys 1920, i a continuació va començar a promoure visites tots els caps de setmana per als que estaven interessats a la compra de parcel·les. Al cap dels anys, diverses famílies van adquirir un terreny a la vora de la mar i hi van construït cases d'estiu, molt aïllades les unes dels altres, i que no tenien una verdadera estructura urbana. Com a conseqüència, el terreny de Finch va ser conegut amb el nom de Recreio (« lleure » en portuguès), i ha estat registrat com a « jardí » Recreio. Durant molts anys, el barri ha conservat un aspecte rural, per la gran distància al centre de la ciutat, la qual cosa li donava un aïllament geogràfic i social important. La regió era anomenada Sertão Carioca, és a dir, « els confins del Rio de Janeiro ». Allà, l'any 1959, es va trobar per a l'última vegada, un jaguar en estat salvatge a la ciutat.

Tanmateix, després del final de la Segona Guerra Mundial, la ciutat de Rio de Janeiro vva viure una explosió demogràfica, i calia tenir noves zones urbanes per acollir tota aquesta gent, i el sud-oest de la ciutat (és a dir els barris de Barra i Recreio, gairebé buits), era la tria natural. L'any 1953, es va llançar un projecte d'urbanització, redactat per l'enginyer i urbanista José Ribeiro Otacílio Savoia, una disposició urbana que ha promogut la integració mediambiental i comunitària, inspirat pels ideals angloamericans.Hi va combinar la topografia natural amb diverses places i parcs omplerts pel bosc natiu. A la mateixa època, es van construir ponts i carreteres cap a l'Oest de la ciutat, la qual cosa ha reduït considerablement la distància i el temps d'accés al barri. Des de llavors, el barri no ha deixat de desenvolupar-se, com l'últim Eldorado de la ciutat.

Platges, parcs i lleure

Hi ha quatre platges on el sol no es pon darrere de grans construccions: Macumba, Pontal, Recreio i una part de la platja Reserva. Són més netes que la mitjana de la ciutat, i les onades hi són més fortes. La platja del Recreio és freqüentada per molts surfistes, i és sobretot l'escena de molts campionats de bodyboard i enregistraments de la TV Globo, una cadena del Brasil. Un carril bici recorre la platja en tota la longitud i les voreres són adornades de mosaics en pedra calcària amb motius marins d'estil portuguès. A la plaça Tim Maia hi ha també una pista de monopatí. Més enllà d'aquests espais naturals, el Recreio dos Bandeirantes té dos parcs dedicats a la protecció dels entorns naturals: parc Chico Mendes i parc Marapendi.

La zona ofereix una multitud d'activitats nàutiques, esportives i culturals. El barri té una gamma de centres comercials, grans superfícies, sales de cinema, i botigues situades al llarg dels eixos viaris, « a la manera americana ». Hi ha també una gran tria de restaurants gastronòmics que proposen receptes tradicionals, especialitats de carn (churrascarias), mariscos, i especialitats culinàries de diferents països.

Referències

Instal·lacions esportives dels Jocs Olímpics d'estiu de 2016
Barris de la zona oest de Rio de Janeiro

redpajama_set_name: RedPajamaWikipedia


Unemployment is two points below the average of my entire life span. Housing prices continue to rise for the seventh straight year. For an incumbent president winning re-election next year should be a walk in the park.
On the other hand, as I write on a chilly rainy Friday, recession worries took a big chunk out of the stock market indices. Besides, United States greenhouse gas emissions rose in 2018: Florida-drowning and Midwest-flooding calamity beckons. Health care costs continue to rise. Banks' capitalization is dangerously low.
Whereas Bill Clinton famously ran for president in 1992 guided by the mantra that "it's the economy, stupid," in 2008 Obama faced the tsunami of a stupid economy crashing down on nearly every American household. Donald Trump may have a trip to beach in 2020, or his successor may prevail on the Clinton theme. In any case, sooner or later, because history rhymes, a president will face the situation presented to Barack Obama as he competed for the presidency in the fall of 2008.
That president should learn from the history of what candidate and then president-elect Obama decided, as he defined his idealistic, frustrating eight years in office even before he was inaugurated.
My book, A Crisis Wasted, is a tale of success and disappointment, aspiration and heartbreak, partial triumph and tragic conclusion. The protagonists are the brilliant, altruistic, myopic, belatedly informed, and unfortunately cautious team Obama assembled in the fall and winter of 2008.
Che Guevara, who probably for good reasons is not quoted much anymore, wrote in his diary days before his death, "It was a good day, considering the exigencies of the life of the guerilla." Under the immense pressures of the economic exigencies of the fall and winter of 2008, the Obama advisers balanced what they considered the art of the possible against the predictions of economic models. For them, avoiding unstoppable bank runs was a good day.
But the models proved wrong (as was later conceded), and the politically possible proved insufficient to deliver to most Americans the promised hope and change. The problem-solvers brought to the crisis the beliefs and values of neoliberalism: the "theory…that proposes that human well-being can best be advanced by…private property rights, free markets, and free trade," and that government should do little more than create and protect markets. This doctrine barred the decision-makers from exercising the full power of government to do what was needed. As a result, the American people, through the contortions of Electoral College system, chose as the next president the person who was, from Barack Obama's perspective, to the single worst person in the United States to succeed him. Donald Trump portended to reverse Obama's policies, ethical compass, factual assumptions, and even his legitimacy as an American.
From this history, there are five political lessons to be drawn for the next president facing a crisis that resembles even in diminished degree the economic and financial catastrophe that fell upon the United States, as well as the global economy, in 2008.
Each of these maxims is a quote from the legendary Andy Grove, CEO of Intel in its glory days, when the chip undergirded the emergence of the information age.
Don't be surprised that they apply to political decisions. The United States, like every other nation-state since the Protestant Reformation gave birth to that form of social organization, is a mixed economy – the public and private sectors overlap. No one in government or business doubts this much denied truth.
In application to government in crisis mode, point one is that the situation must be clearly understood. From March 2008, when Larry Summers told Treasury Secretary Hank Paulson that Fannie Mae and Freddie Mac were bankrupt, to January 9, 2009, when Obama's advisers misstated the spike in unemployment that was about to occur, neither the Republican nor incoming Democratic advisers to the presidents grasped and explained publicly the dimensions of the great recession. They did understand the risks to the banking system, and they dealt successfully with that sector (no small feat). But they did not inform the presidents accurately about what would happen to the real economy. They can be forgiven, but rule one in decision-making is to "wake up and listen" so that forgiveness is not necessary.
The reason to say "no" is to squeeze from advisers better plans. On December 16, 2008, Obama's advisers gave him four options for his economic strategy. All fell short in scale and scope. None was as large or innovative as the situation demanded. "No" would have been the right answer to all questions put to him that freezing day in Chicago.
The more "lasting solution", rule three to follow, would have been public spending on the infrastructure of the five basic platforms for all social and economic well-being in a modern economy. Obama's advisers should have begged him, and his supporters in Congress should have insisted, in a massive reconstruction of these networks: power, communications, transportation, water, and sewage. In the last decade private savings has exceeded private investment by about four trillion dollars. Government's job was to bring all that money into these platforms – by tax breaks, public-private partnerships, catalytic public spending, research and development money, or whatever it took. Neoliberals could not bring themselves to argue for such measures. Regret came too late.
Fourth, when the economic advisers told Barack Obama's astute councilor David Axelrod about their recommendation that he spend a record-breaking sum just to get unemployment barely under 8% by the mid-terms in 2010, he said, "That's going to be tough to message." Instead of changing the plan, the team changed the topic. No sooner than the stimulus was approved in early February, the Obama Administration turned to health care, reform number one, and emissions reduction, reform number two. Neither produced a compelling narrative. The government's leaders were not well understood. Political gridlock ensued.
Lastly, by early January 2009, all knew that the winds had shifted. At the deepest level, the neoliberal prescriptions, which all had sworn by, were defunct. More immediately, all knew also that the economic recovery plan had little chance of producing happy results. At best, the depression would be avoided. It was. But, as Barack Obama said to his chosen Treasury Secretary, Tim Geithner, "that's not enough." And it was not sufficient to produce the generational change that he so admirably sought as his legacy.
My history, drawn from more than four dozen interviews, percipient observation, memoirs, and other evidence, offers these lessons in regret, not recrimination. I think they will serve better than the maxims of defunct neoliberalism. When the presidential candidates think, in the few small hours they have to themselves in the motel rooms of Iowa and New Hampshire, about what has to be decided by the person who holds the job they are seeking, my book might be worth a skim.
Reed Hundt was a member of the transition teams for the Clinton and Obama presidencies. He was the chairman of the Federal Communications Commission from 1993–97. He has written four books, taught at Yale College, Law School, and School of Management, practiced law in California and Washington, DC, started for-profit and non-profit firms, served as a board member for numerous technology and communications firms, and raised a family with his wife Betsy in Chevy Chase, Maryland. He is the author of You Say You Want a Revolution and In China's Shadow.


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Solution: A balloon containing 0.146 mol Ne gas has a volume of 1.7 L at 2.1 atm and 28 °C. How many grams of neon should be added to the balloon to increase the volume to 3.1 L at the same pressure and temperature?
A balloon containing 0.146 mol Ne gas has a volume of 1.7 L at 2.1 atm and 28 °C. How many grams of neon should be added to the balloon to increase the volume to 3.1 L at the same pressure and temperature?


text:
/* Contains code for handling plugin loading/removing and status management. */

import RG from '../src/rg';
import {ObjectShell} from '../src/objectshellparser';
import {expect} from 'chai';

import * as AllCode from '../src/battles';

export interface PluginData {
    [key: string]: any;
}

export interface GameEntry {
    levels: any[];
    game: any;
}

const PLUGIN_TYPES = [
    'plugin', 'items', 'actors', 'elements', 'system', 'spell'
];

/* Each plugin is associated with an entry which stores the plugin code. */
export class PluginEntry {

    public _enabled: boolean;
    public _type: string;
    public _data: PluginData;
    public _name: string;
    public _description: string;
    public _status: string;
    public _errorMsg: string;
    public _fileType: string;

    public _onLoad: () => void;
    public _onRemove: () => void;
    public _test: (expect: any) => void;

    constructor(json) {
        this._enabled = false;
        this._type = json.type;
        this._data = json.data;
        this._name = json.name;
        this._description = json.description;
        this._fileType = json.fileType;
        this._status = 'UNLOADED';
        this._errorMsg = '';
        this._test = json.test;

        this._onLoad = json.onLoad;
        this._onRemove = json.onRemove;
    }

    public getData(): PluginData {return this._data;}

    public hasError() {
        return (/ERROR/).test(this._status);
    }

    public getError(): string {
        return this._errorMsg;
    }

    public disable(): void {
        if (this._enabled) {
            if (typeof this._onRemove === 'function') {
                try {
                    this._onRemove();
                    this._status = 'UNLOADED';
                    this._errorMsg = '';
                }
                catch (e) {
                    this._errorMsg = e.message;
                    this._status = 'UNLOAD ERROR';
                    throw new Error(`${this._name}: ${e.message}`);
                }
            }
            this._enabled = false;
        }
    }

    public enable(): void {
        if (!this._enabled) {
            if (typeof this._onLoad === 'function') {
                try {
                    this._onLoad();
                    this._status = 'LOADED';
                    this._errorMsg = '';
                }
                catch (e) {
                    this._errorMsg = e.message;
                    this._status = 'LOAD ERROR';
                    throw new Error(`${this._name}: ${e.message}`);
                }
            }
            this._enabled = true;
        }
    }

    public getName(): string {
        return this._name;
    }

    public getType(): string {
        return this._type;
    }

    public isEnabled() {
        return this._enabled;
    }

    public runTest(): void {
        if (this._test) {
            this._test(expect);
        }
    }

    public toJSON() {
        return {
            type: this._type,
            fileType: this._fileType,
            name: this._name,
            data: this._data,
            description: this._description
        };
    }

}

/* Manager contains list of plugins that have been loaded. */
export class PluginManager {

    /* Returns a plugin manager from json. */
    public static fromJSON(jsonArr): PluginManager {
        const pm = new PluginManager();
        jsonArr.forEach(plugin => {
            if (plugin.fileType === 'json') {
                pm.readJSON(plugin);
            }
            else {
                pm.loadScript(plugin.data);
            }
        });
        pm.enableAll();
        /* TODO */
        return pm;
    }

    private _plugins: PluginEntry[];
    private _errorMsg: string;
    private _readCallbacks: {[key: string]: (entry: PluginEntry) => void};
    private _globalRefsWereSet: boolean;

    constructor() {
        this._plugins = [];
        this._errorMsg = '';
        this._readCallbacks = {
            [RG.TYPE_ACTOR]: this.parseShellsOnRead,
            [RG.TYPE_ITEM]: this.parseShellsOnRead,
            [RG.TYPE_ELEM]: this.parseShellsOnRead
        };
        this._globalRefsWereSet = false;
    }

    /* Loads plugin data in JSON format. */
    public readJSON(json): PluginEntry {
        json.fileType = 'json';
        const entry = this.addPlugin(json);
        const type = entry.getType();

        if (this._readCallbacks[type]) {
            this._readCallbacks[type](entry);
        }
        return entry;
    }

    /* Loads a script using eval. */
    public loadScript(text: string): PluginEntry {
        let entry: PluginEntry = null;
        try {
            this.setGlobalRefs();
            /* tslint:disable */
            let pluginData = null;
            // Note that eval'ed text must set the pluginData
            eval(text);
            /* tslint:enable */
            if (pluginData) {
                pluginData.data = text;
                pluginData.fileType = 'script';
                entry = this.addPlugin(pluginData);
                this._errorMsg = '';
            }
            else {
                this._errorMsg = 'no pluginData specified in the script';
            }

            if (this._globalRefsWereSet) {
                this.unsetGlobalRefs();
            }
            /* eslint-enable */
        }
        catch (e) {
            this._errorMsg = e.message;
            if (this._globalRefsWereSet) {
                this.unsetGlobalRefs();
            }
            throw e;
        }
        return entry;
    }

    public loadGameFromScript(text: string): GameEntry {
        const entry = {
            levels: null, game: null
        };
        try {

            /* tslint:disable */
            let game = null;
            let levels = null;
            this.setGlobalRefs();
            eval(text);
            /* tslint:enable */

            if (game) {
                entry.game = game;
            }
            else if (levels) {
                entry.levels = levels;
            }
            else {
                throw new Error('Script must set game or levels!');
            }
            if (this._globalRefsWereSet) {
                this.unsetGlobalRefs();
            }
        }
        catch (e) {
            this._errorMsg = e.message;
            if (this._globalRefsWereSet) {
                this.unsetGlobalRefs();
            }
            throw e;
        }
        return entry;
    }

    /* Returns true if any of the plugins are enabled. */
    public anyPluginsEnabled(): boolean {
        for (let i = 0; i < this._plugins.length; i++) {
            if (this._plugins[i].isEnabled()) {
                return true;
            }
        }
        return false;
    }

    public findPlugin(name): PluginEntry | null {
        return this._plugins.find(p => p._name === name);
    }

    public getPlugins(): PluginEntry[] {
        return this._plugins.slice();
    }

    public getPluginNames(): string[] {
        return this._plugins.map(p => p._name);
    }

    public addPlugin(pluginData): PluginEntry {
        this.validateType(pluginData);
        const entry = new PluginEntry(pluginData);
        this._plugins.push(entry);
        return entry;
    }

    public deletePlugin(name: string): void {
        const index = this._plugins.findIndex(p => p.getName() === name);
        if (index >= 0) {
            this._plugins[index].disable();
            if (this._plugins[index].hasError()) {
                this._errorMsg = this._plugins[index].getError();
            }
            this._plugins.splice(index, 1);
        }
    }

    public disablePlugin(name: string): void {
        const plugin: PluginData = this.findPlugin(name);
        this._errorMsg = '';
        if (plugin) {
            this.setGlobalRefs();
            plugin.disable();
            if (plugin.hasError()) {
                this._errorMsg = plugin.getError();
            }
            this.unsetGlobalRefs();
        }
        else {
            this._errorMsg = 'Could not find plugin ' + name;
        }
    }

    public enablePlugin(name: string): void {
        const plugin: PluginData = this.findPlugin(name);
        if (plugin) {
            this.setGlobalRefs();
            plugin.enable();
            if (plugin.hasError()) {
                this._errorMsg = plugin.getError();
            }
            this.unsetGlobalRefs();
        }
    }

    public enableAll(): void {
        this._errorMsg = '';
        this.setGlobalRefs();
        this._plugins.forEach(plugin => {
            plugin.enable();
            if (plugin.hasError()) {
                this._errorMsg += plugin.getError() + '\n';
            }
        });
        this.unsetGlobalRefs();
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                parser.parseShellCateg(propType, data);
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            msg += ` but got |${pluginData.type}|`;
            throw new Error(msg);
        }
    }

}

redpajama_set_name: RedPajamaGithub


text:
Skiiing/Snowboarding
2018-19 Athletic Physical Forms
2019-2020 Composite Schedule
2018-19 Game Programs
Athletic News
Bobcat Club
Facility Use for Community Member Info
Meet the AD
Remembering Carla
Remembering Megan
2017 EADA
Notice of Athletic Recruitment
Bobcat Walk and Locker Legacy
Bobcat Club Brochure
Nothstein paces Bobcats to strong performance at Track Nationals
COLORADO SPRINGS, Colo. --- Freshman Tyler Nothstein (Orefield, Pa.) finished fourth in the points race and ninth in the overall individual omnium to lead the Lees-McRae College cycling team to a solid performance at the USA Cycling Collegiate Track Nationals this weekend at the Colorado Springs Velodrome.
Marian University claimed the overall team omnium title, taking maximum points from all but two events en route to a total of 1200 points. Fort Lewis College was second with 843 markers, followed by Lindenwood University (768), University of Colorado – Boulder (764), and Midwestern State University (742). Lees-McRae turned in a strong 11th-place performance with 206 points despite only sending three riders to the event.
The Bobcats opened the weekend with a strong day on Friday, as both Nothstein and Cam Mancuso (Greenwood, Pa.) each earned a spot in Saturday's points race final with a pair of impressive runs in the qualifying heats. Nothstein continued his strong weekend in the Flying 200-meter time trial, finishing 14th with a mark of 11.685, as Zachary Houlik palced 31st with a mark of 12.302 seconds.
Nothstein and Houlik added to the Bobcats' point total in Saturday's sprint, placing 15th and 31st, respectively, as Nothstein finished just 16 points out of the top 10. The freshman followed with the performance of the weekend in Saturday evening's points race final, earning a spot on the podium in fourth place just 15 points behind the leader. Mancuso rode to a strong finish as well, cracking the top 20 with a total of 467.20.
The Bobcats continued their run on Sunday, as Nothstein posted his third top-15 performance with a 14th-place finish in the time trial, crossing the line with a mark of 1:09.414. Houlik delivered a strong ride of his own, placing 38th out of over 70 riders with a time of 1:11.570.
The trio took the track together for the first time in Sunday's team pursuit, putting together a strong ride of 5:09.431. The Bobcats then capped the weekend in the scratch race, as Nothstein cemented his spot among the top 10 in the omnium with a 12th-place performance after placing third in his heat. Mancuso closed out the weekend with a solid performance in the minor final, finishing 12th.
Lees-McRae returns to action on Saturday when the Bobcats travel to Seneca, S.C. to take part in Clemson University's Tiger Territory Mountain Race.
- LMC -
191 Main Street | PO Box 128 | Banner Elk, NC | 28604 | 828.898.5241


text:
Favorite Guitarist
http://your-favourite-guitarist-guitar-hero.blogspot.com
ERIC CLAPTON - BIOGRAPHY
Tags: clapton album
Eric Patrick Clapton was born on March 30, 1945, in his grandparent's house at 1, The Green, Ripley, Surrey, England. He was the illegitimate son of Patricia Molly Clapton and Edward Fryer, a Canadian soldier stationed in England. After W.W.II Fryer returned to his wife in Canada, Patricia left Eric in the custody of his grandparents, Rose and Jack Clapp. (The surname Clapton is from Rose's first husband, Reginald Cecil Clapton.) Patricia moved to Germany where she eventually married another Canadian soldier, Frank McDonald.
Young Ricky (that's what his grandparent's called him) was a quiet and polite child, an above average student with an aptitude for art. He was raised believing that his grandparents were his parents and his mother was his sister, to shield him the stigma that illegitimacy carried with it. The truth was eventually revealed to him, at the age of nine by his grandmother. Later, when Eric would visit his mother, they would still pretend to be brother and sister.
As an adolescent, Clapton glimpsed the future when he tuned in to a Jerry Lee Lewis appearance on British television. Lewis's explosive performance, coupled with young Eric's emerging love of the blues and American R&B, was powerful enough to ignite a desire to learn to play guitar. He commenced studies at the Kingston College of Art, but his intended career path in stained-glass design ended permanently when the blues-obsessed Clapton was expelled at seventeen for playing guitar in class. He took a job as a manual laborer and spent most of his free time playing the electric guitar he persuaded his grandparents to purchase for him. In time, Clapton joined a number of British blues bands, including the Roosters and Casey Jones, and eventually rose to prominence as a member of the Yardbirds, whose lineup would eventually include all three British guitar heroes of the sixties: Clapton, Jimmy Page, and Jeff Beck. The group became a sensation for their blues-tinged rock, as did the budding guitar virtuoso Clapton,
who earned the nickname "Slowhand" because his forceful string-bending often resulted in broken guitar strings, which he would replace onstage while the crowd engaged in a slow hand-clapping.
Despite the popularity of the band's first two albums, Five Live Yardbirds and For Your Love, Clapton left in 1965, because he felt the band was veering away from its bluesy bent in favor of a more commercially viable pop focus. He joined John Mayell's Bluesbreakers almost immediately, and in the ferment of that band's purist blues sensibilities, his talent blossomed at an accelerated rate--he quickly became the defining musical force of the group. "Clapton is God" was the hue and cry of a fanatic following that propelled the band's Bluesbreakers album to No. 6 on the English pop charts. Clapton parted company with the Bluesbreakers in mid-1966 to form his own band, Cream, with bassist Jack Bruce and drummer Ginger Baker. With this lineup, Clapton sought "to start a revolution in musical thought . . . to change the world, to upset people, and to shock them." His vision was more than met as Cream quickly became the preeminent rock trio of the late sixties. On the strength of their first three albums (Fresh Cre
am, Disraeli Gears, and Wheels of Fire) and extensive touring, the band achieved a level of international fame approaching that of the Rolling Stones and the Beatles, and Clapton became even more almighty in the minds of his fans. In fact, the "Clapton is God" gospel contributed largely to Cream's disintegration--the band had always been a three-headed beast of warring egos, and their intense chemistry, exacerbated by the drug abuse of all three, inevitably led to a farewell tour in 1968 and the release of the Goodbye album in 1969. Early in 1969, Clapton united with Baker, bassist Rick Grech, and Traffic's Steve Winwood to record one album as Blind Faith, rock's first "supergroup." In support of their self-titled album, Blind Faith commenced a sold-out, twenty-four-city American tour, the stress of which resulted in the demise of the band less than a year after its inception.
Clapton kept busy for a time as an occasional guest player with Delaney & Bonnie, the husband-and-wife team that had been Blind Faith's opening act during their tour. A disappointing live album from that collaboration was released in 1970, as was Clapton's self-titled solo debut. That album featured three other musicians--bassist Carl Radle, keyboardist Bobby Whitlock, and drummer Jim Gordon--from Delaney's band, and yielded a modest pop hit with Clapton's version of J.J. Cale's "After Midnight." The collective proceeded to baptize themselves Derek and the Dominos, and commenced recording Clapton's landmark double album Layla and Other Assorted Love Songs, with the added contribution of slide guitarist Duane Allman. An anguished lament of unrequited love, "Layla" was inspired by a difficult love triangle between Clapton, his close friend George Harrison, and Harrison's wife Pattie (she and Clapton eventually married in 1979 and divorced in 1988). Unfortunately, personal struggles and career pressure on the gu
itarist led to a major heroin addiction. Derek and the Dominos crumbled during the course of an American tour and an aborted attempt to record a second album.
Clapton withdrew from the spotlight in the early seventies, wallowing in his addiction and then struggling to conquer it. Following the advice of the Who's Pete Townsend, he underwent a controversial but effective electro-acupuncture treatment and was fully rehabilitated. He rebounded creatively with a role in the film version of Townsend's rock opera, Tommy, and with a string of albums, including the reggae-influenced 461 Ocean Boulevard, which yielded a chart-topping single cover of Bob Marley's "I Shot the Sheriff." Some critics and fans were disappointed by Clapton's post-rehab efforts, feeling that he had abandoned his former guitar-heavy approach in favor of a more laid-back and vocal-conscious one.
Just One Night, Clapton's galvanizing 1980 live album, reminded devotees just exactly who their guitar hero was, but unfortunately, this period marked Clapton's critical slide into a serious drinking problem that eventually hospitalized him for a time in 1981. He experienced a creative resurgence after reining in his alcoholism, releasing a string of consistently successful albums--Another Ticket (1981), Money and Cigarettes (1983), Behind the Sun (1985), August (1986), Journeyman (1989)--and turning his personal life around. Though some say Clapton never regained the musical heights of his heroin days, his legend nevertheless continued to grow. That he was a paragon of rock became more than apparent when Polygram released a rich four-CD retrospective of his career, Crossroads, in 1988; the set scored Grammy awards for Best Historical Album and Best Liner Notes.
In late 1990, the fates delivered Clapton a terrible blow when guitarist Stevie Ray Vaughan and Clapton road crew members Colin Smythe and Nigel Browne--all close friends of Clapton's--were killed in a helicopter crash. A few months later, he was dealt another cruel blow when Conor, his son by Italian model Lori Del Santo, fell forty-nine stories from Del Santo's Manhattan high-rise apartment to his death. Clapton channeled his shattering grief into writing the heart-wrenching 1992 Grammy-winning tribute to his son, "Tears in Heaven." (Clapton received a total of six Grammys that year for the single and for the album Unplugged.)
In 1994, he began once again to play traditional blues; the album, From the Cradle, marked a return to raw blues standards, and it hit with critics and fans. The fifty-one-year-old Clapton shows no signs of slowing down: in February of 1997 he picked up Record of the Year and Best Male Pop Vocal Performance Grammys for "Change the World," from the soundtrack of the John Travolta movie Phenomenon.
Already a double inductee into the Rock & Roll Hall of Fame as a member of the Yardbirds and Cream, a third nod as a solo artist is an inevitable honor for the legendary guitarist. Until Clapton springs his next album on a waiting world, fans can content themselves with his latest side project, TDF. The band's techno-pedigreed 1997 release, Retail Therapy, represents a marked musical departure from Clapton's blues-rock roots, and he appears on the album with the correspondingly off-the-wall pseudonym "X-Sample."
Next came the acclaimed Pilgrim, which captured the Grammy nomination for Best Pop Album in '98. In 1999 he won a Grammy for his performance on "The Calling" from Santana's Supernatural. Clapton revisited the blues with friend and musical legend BB King in 2000's Riding With The King, garnering the artist more platinum and a Grammy nomination in a career full of chartbusters and precious metal.
The only triple inductee into the Rock & Roll Hall of Fame (as a member of both The Yardbirds and Cream and as a solo artist), Eric Clapton continues to astonish and delight a vast spectrum of music lovers. It's a legacy that continues with the release of Reptile, the latest journey in the lifelong musical odyssey of an authentic musical genius.
Favorite Guitarist popular guitarist
This post first appeared on Favorite Guitarist, please read the originial post: here
THE ENEMY OF THE UNLIVED MEANINGLESS LIFE
New Music: 38 Spesh & Harry Fraud Ft Stove God Cooks "Speshal" & New Album Announcement - @IamSpesh @HarryFraud @Stovegodcooks
Sino Msolo – Fezisa Album
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text:
Q: Infinite loop testing How could I test an infinite loop?
For example:
func.py
def func():
    while True:
        char = input().lower()
        if char == 'q':
            break
        elif char.isalpha():
            print("It's not a number")
        if int(char) == #some_number
            break
        else:
            print('Try again')

test.py
def test_func():
    ???

Is there any solution for testing this?

A: You can use unittest to mock the user's input:
import builtins
from unittest.mock import patch

def func():
    while True:
        char = input().lower()
        if char == 'q':
            break
        elif char.isalpha():
            print("It's not a number")
        if int(char) == 3:
            break
        else:
            print('Try again')

def test_func(inputs):
    with patch("builtins.input") as input_mock:
        input_mock.side_effect = inputs
        func()

test_func(["q"])
test_func(["3"])
test_func(["4", "5", "6"])  # StopIteration error indicates this input is not sufficient for the function to return
test_func(["a", "b", "c", "q"])  # ValueError indicates a bug in the function
test_func(["4", "5", "6", "q"])  # Try again 3 times as expected

EDIT: You could also use unittest to capture the printed output and return it, so that you can check this output systematically against the expected output.
import builtins
from unittest.mock import patch
import io

def test_func(inputs):
    with patch("builtins.input") as input_mock, \
         patch("sys.stdout", new_callable=io.StringIO) as output_mock:
        input_mock.side_effect = inputs
        try:
            func()
        except StopIteration:
            print("FUNCTION DID NOT RETURN")
        return output_mock.getvalue().strip().split("\n")

print(test_func(["q"]) == [""]) # True
print(test_func(["4", "5", "6", "q"]) == ['Try again', 'Try again', 'Try again']) # True

redpajama_set_name: RedPajamaStackExchange


Kids love the delightful purplish color of this refreshing snack! Just add ice to turn it into a delicious sorbet.
Banana Blueberry Orange Smoothie is rated 5.0 out of 5 by 15.
Rated 5 out of 5 by BKCA from Naturally sweet! The orange adds a great natural sweetness that my 6 and 8 year old loved! I used 1/2 cup water with about 1/2 cup ice cubes because my banana wasn't frozen. I would think the fresher your ingredients, the less water and more ice you could change out to increase the thickness. Great easy recipe!
Rated 5 out of 5 by Snelson from Good balanced taste; not too sweet I've always had a love for green smoothies, but I thought about trying some fruit smoothies this week. Tried this simple recipe and I really enjoyed it. Every fruit balances each other. I followed the recipe exactly.
Rated 5 out of 5 by Kdrobs from Smoothie the whole family loves I love this simple all fruit smoothie! The texture is great - and I really like that I don't need to add yogurt. I sometimes add in frozen raspberries to the recipe (handful) for a nice sweet taste (masks the banana taste a bit).
Rated 5 out of 5 by Arri from Great if you like bannanas It is so good! It is great for kids and is healthy too! It has a strong banana taste that might not be for you, if banana is not your thing. However, I love it!
Rated 5 out of 5 by dawndirect from Loved it but added more . . . I didn't know what I wanted for dinner so when it got late I decided to look for a smoothie as an alternative. I followed the instructions but added ice, 1 t. maca powder, 1/2 scoop of vanilla protein powder, about a teaspoon of peanut butter powder, a tablespoon of coconut oil, a large spoon of unflavored Fage yogurt, and a couple of mini ice cubes of beet juice I had in the freezer (from when I juiced them and had too many, I made mini ice cubes for such a reason). It was satisfying and I didn't go to bed hungry . . . nor was my stomach having to work too hard before bed.
Rated 5 out of 5 by Bethany from Super tasty!!! I bought my Vitamix a few weeks ago and have been experimenting with smoothie recipes. This is one of my faves! The flavor is great and it's not too sweet. I used frozen blueberries that seemed to make it even better!
Rated 5 out of 5 by JohnO from Great smoothies I use about 4oz of OJ, a handful of frozen blueberries, 1/2 fresh banana, maybe some pure grape juice or other juice we might have, or peel a tangerine and throw it in the mix, and a handful of ice cubes. Hit the switch and what comes out is a wonderful smoothie, that is healthful, about 150 calories (use only unsweetened fruit juices) and taste great. I have this every morning during my Bible time.
Rated 5 out of 5 by kdishroon from Very simple and tasty I replaced the water with orange juice because I didn't have an orange and I added a few ice cubes because my blueberries weren't frozen...so quick and simple yet very tasty.


Many suggestions to help your career may seem quite obvious, but can often be overlooked or not fully explored.
The career choices you make will become a primary factor in defining your Business Analyst career. No matter how great you think your experience and skill set is, you need to effectively communicate this in your job search. Too many people think they are perfect for a job role or contract, but forget there is a lot of competition out there. Here are 10 tips to help your career and job search, particularly if you live in the UK.
Some of these tips can also be tailored and applied to your job search, regardless of your location.
Job sites are still the number one source for hires in the UK. Utilise specialist niche job sites that have a wide choice of Business Analyst jobs – Examples are Business Analyst Jobs and Technojobs.
This is your most important career tool and you should spend sufficient time on it. So many CVs are either badly formatted, have key information hidden or are too lengthy. Get your CV reviewed by a professional. Highlight the key experience, achievements and qualifications that are relevant to the BA role you are applying for at the top of your CV.
Here is your opportunity to create a public CV. Again, put in some effort here, as this is where employers may view your skills and experience. LinkedIn also provides the opportunity to connect and keep in touch with other BA professionals.
Did you know that approximately 30-40% of all jobs do not get advertised? In most cases, recruiters or employers will use their existing network to shortlist candidates. They will also access CV Databases offered by job sites. Make sure your CV can be found with all the right keywords.
Make the most of the Business Analyst events, conferences or meetings you attend. Networking is a great way to meet new contacts that may be able to refer or recruit you.
Demonstrate your knowledge and passion for business analysis to potential employers. This may be achieved through blogging, conducting research or publishing content on specialist BA websites.
If you have prior experience, broaden your job search to include contracting. There is a massive demand in the Business Analysis field for contractors in the UK and this can be very lucrative financially while providing a platform for you to meet different clients on diverse projects.
Work towards achieving the relevant Business Analyst qualifications or certifications, especially if you are looking at contract positions. The client will expect you to hit the ground running so you need to make sure your skills are up-to-date.
Manage your online profile. Many employers will "Google" you before hiring so always ensure that anything published online or on social media in general, will do you and your career justice without any negativity.
Be confident in following up on job applications or contacting your network on employment opportunities. Really - Don't hold back so that you do not miss out. Chase recruiters so they know how serious you are.
Your Business Analyst career should be driven by you, so maximise any opportunity that comes your way and always be proactive.
This article was written by Anthony Sherick who set up Business Analyst Jobs to provide a job site and career information dedicated to Business Analysts.


Come Kill Lunas for Extra Life.
So November the3rd at 18:00 GMT (14:00EST) Come kill me for Extra Life.
Event will last Four hours, Please use PVP channel for this event.
Held in Shambala, where I will be attempting to discise myself as a remotely competent player.
There will be prizes, random selection from PVP channel at the end of each hour.
and a couple of Random selected caches from SWL past.
Also everyone who donates to my Extra Life page and puts there character name in the comments, enters the draw for One full set of Cyberpunk threads cosmetic Item.
All items from my personal bank space.
Had to postpone this for family reasons.
I am pro-Killing Lunas, for charity.


Hydro is headed into stormy waters, according to a new report that links deforestation to reduced power output for a proposed dam in Brazil. While Amazonian rain forests might seem miles away from your portfolio profits, there are direct impacts and sector-wide implications from these new findings. Here's what you need to know.
The Proceedings of the National Academy of Sciences released a report (link opens a PDF) last week turning power preconceptions upside down. Before this week, commonsense thinking proposed that if forests around a river were chopped down, more water would hit dam reservoirs, increasing capacity and maximizing electricity generation. In reality, although trees do take their fair share of groundwater out of river flow, they play a vital (and relatively larger) role in cloud and rainfall creation.
The study focuses its findings on Brazil's 11,200 MW Belo Monte Dam, currently under construction. According to the report, 40% deforestation in key forested areas could drop capacities by as much as 75% during dry months.
While the second-largest hydroelectric dam in the world is collectively owned by the Brazilian government and local energy corporations, this study is hardly good news for Duke Energy's ownBrazil operations. The North Carolina-based utility owns eight hydro facilities in Brazil with a total generation capacity of 2,300 MW. In its latest earnings report, CEO Jim Rogers noted that low reservoir levels helped knock 5% off the company's adjusted EPS. Rogers assured investors that Duke "will continue to monitor the reservoir levels." Unfortunately, monitoring is all that the company is capable of.
Rain forests aside, this new report is also a reminder that hydroelectric power is hardly a steady source. Belo Monte is expected to hit 85% of its 11,000 MW capacity every April, but plummets to 5% in September. According to the study, the dam's annual generation could average out to just 35% (3,850 MW) of total capacity.
NextEra Energy sold off its last hydro assets in March to "further optimize [our] generation portfolio and concentrate [our] resources." NextEra is the largest renewables energy producer in the United States, and has been adding on heavily to other alternative energies. Just last week, it announced an order for 59 of General Electric's new 1.7 MW wind turbines, the largest and most efficient turbines to date.
FirstEnergy is following NextEra's lead, and plans to sell its 1,240 MW of hydro assets by 2014. The sale will improve FirstEnergy's debt dilemma, but should also help the utility concentrate resources on more stable energy sources.
Hydroelectric power was once espoused as the cleanest, greenest renewable energy around. However, over the decades, its expected efficiency has dropped as environmentalists and economists alike shattered investors' dreams.
Investing in the energy sector is a moving target, and wise investors will keep track of the latest news to make sure that their energy investments' energy portfolios will continue to pump profits for their own portfolios.
Hydro may not hold up, but there's another clean energy source that's making a comeback. As the nation moves increasingly toward environmentally friendly energy, Exelon is perfectly positioned to capitalize on having the largest nuclear fleet in North America. This strength, combined with an increased focus on balance sheet health and its recent merger with Constellation, places Exelon and its resized dividend on a short list of the top utilities. To determine if Exelon is a good long-term fit for your portfolio, you're invited to check out The Motley Fool's premium research report on the company. Simply click here now for instant access.
The article 1 Growing Problem Could Endanger Hydropower originally appeared on Fool.com.
Motley Fool contributor Justin Loiseau owns shares of General Electric Company. You can follow him on Twitter, @TMFJLo, and on Motley Fool CAPS, @TMFJLo.The Motley Fool owns shares of General Electric Company. Try any of our Foolish newsletter services free for 30 days. We Fools may not all hold the same opinions, but we all believe that considering a diverse range of insights makes us better investors. The Motley Fool has a disclosure policy.