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AOR and Melodic Rock News on 13/05/2014 Part I
ARENA ROCKERS NIGHT RANGER'S NEW TRACK HAS EXCLUSIVE WORLDWIDE PREMIERE ON MELODICROCK.COM TODAY :
(New York, NY) – Night Ranger fans around the globe check out the exclusive worldwide premiere of the new track "I'm Coming Home" on MelodicRock.com. The hook-laden song, featuring lead vocals by drummer Kelly Keagy, is taken from the band's forthcoming album,High Road.
Due out on June 10 in North America via label home Frontiers Records, High Road is produced by the band itself and will be available in two formats – a standard CD version and a deluxe version which includes a bonus track and a DVD featuring a background look at the making of the album along with video clips. High Road can be pre-ordered now at Amazon as the standard and deluxe version below. For fans who order the album via iTunes, the title track "High Road" and "I'm Coming Home" are available as 'instant grat' tracks.
In other Night Ranger news, the band recently delighted huge audiences at both the M3 Festival in Columbia, MD and the Frontiers Rock Festival in Milan, Italy. Look for them to tour North America this summer in support of High Road. In the meantime, the first single from the album, also entitled High Road, has just gone for adds at radio. Singer/bassist/songwriter Jack Blades' craftsmanship as a songwriter is also featured on Journey guitarist Neal Schon's upcoming album, So U, due out in North America on May 19.
Night Ranger's legendary hits "Sister Christian," "(You Can Still) Rock in America," and "Don't Tell Me You Love Me" are songs that have each significantly impacted popular culture and expanded their ever-growing fanbase since the band's inception thirty years ago. Over the years, the band's music has made notable contributions to and been featured in many different areas of media and popular culture. Night Ranger's songs can be heard in the Rock Band and Guitar Hero video games; Rock of Ages hit Broadway musical and film; the Oscar-nominated film Boogie Nights; Fox's hit TV Show American Dad; JBL's "Hear The Truth" campaign; and many more! To date, Night Ranger has sold 17 million units worldwide and boasts several platinum- and gold-certified albums.
Night Ranger is Jack Blades (bass guitar, vocals), Kelly Keagy (drums, vocals), Brad Gillis (lead & rhythm guitars), Joel Hoekstra (lead & rhythm guitars) and Eric Levy (keyboards).
For more information please visit: www.nightranger.com / www.frontiers.it.
ICONIC ROCK BAND CHICAGO TO RELEASE 36th ALBUM "NOW" IN JULY VIA FRONTIERS:
Chicagoone of the longest running, successful and iconic rock bands in American musical historyis set to release their 36th album "Now" – Chicago XXXVI in Europe on July 4 and in the U.S. July 8 via Frontiers Records. Featuring 11 brand-new, original songs from the group known for their groundbreaking rock-with-horns sound, "Now" Chicago XXXVI was written and recorded on the road during the band's rigorous, never-ending tour schedule, playing for fans who have supported them since they formed in 1967.
Putting aside an awesome accumulation of honors, awards, accomplishments, numbers and peer respect, this remarkable group of talented musicians continues to make history with a new recording process geared towards musical excellence, doing the business of music "NOW," while reckoning with the logistical realities of a world-wide touring band. Produced by Chicagofounding members Robert Lamm (keyboard, guitars, vocals), Lee Loughnane (trumpet, guitar, percussion, vocals), James Pankow (trombone, percussion, keyboards, vocals), Walter Parazaider (woodwinds, backing vocals) along with Jason Scheff (bass, vocals), Tris Imboden (drums, percussion), Keith Howland (guitars, vocals), Lou Pardini (keyboards, vocals) and Walfredo Reyes, Jr., (percussion)the album was recorded on "the Rig," the band's customized mobile recording system. Each songwriter oversaw the production of their compositions, and the band collaborated as a cohesive unit throughout the writing and recording process.
Pre-orders for "Now" Chicago XXXVI are available on the band's website here: chicago-now.com/ and will also be available soon via Amazon and iTunes.
Of the new album and the band's continued growth and evolution, Lamm says, "There's certainly more context, and there's certainly more musical ability, and perception rather than youthful naivetй that we had when we started." Loughnane says, "Thank goodness, we have 46 years of track record behind us. We're just trying to grow the legacy even more." The bandas alwayswill tour heavily in 2014 to support the new album. "Outside of being creative and making new music, going out, doing even better shows, I think we've put together a show right now that's the best one we've ever had out there, which, as long as that curve is going up, I don't think we have to sit back and re-assess things," says Parazaider. Check out the album's EPK:
Originally formed as the Chicago Transit Authority in 1967, the band found almost immediate success and have become a bona fide institution of American music. Their signature sound of solid rock songs augmented by the best horns in the business has endeared them to several generations of music fans. Hit singles include "If You Leave Me Now," "Saturday In The Park," "Does Anybody Really Know What Time It Is," "Feelin' Stronger Every Day," "25 or 6 to 4," "Beginnings," "I'm A Man," "Hard To Say I'm Sorry," "(I've Been) Searching So Long," "Look Away," "Just You And Me" and "Old Days," among others. The band has accumulated a total of 47 gold and platinum records awards.
"47 years later and to think that people – young people especially, but all ages, are actually still discovering Chicago's music!," says Pankow. "People have become fed up with all of the robotic programmed junk and they come to our shows to hear and witness the real thing – gifted veteran musicians with serious chops – no smoke and mirrors or lip-syncing. Wow, what a concept!"
Here's the "Now" Chicago XXXVI track listing: Now, More Will Be Revealed, America, Crazy Happy, Free At Last, Love Lives On, Something's Coming I Know, Watching All The Colors, Nice Girl, Naked In The Garden of Allah, Another Trippy Day.
Chicago is on the road now and will tour throughout the rest of the year. They will be in the U.S. through early June, and kick off a European tour June 26 in Paris, France before hitting Italy, Spain, Germany, Austria and Norway. They return to the U.S for an August 1 date at Los Angeles' Greek Theatre and have New York-area shows August 16 at PNC Bank Arts Center in Holmdel, NJ and August 17 at Jones Beach in Wantagh, NY. Tour dates can be found here: www.chicagotheband.com/tour.html.
TESLA NEW DIGITAL SINGLE "SO DIVINE…" AVAILABLE NOW:
Frontiers Records is pleased to announce the digital release of US multi-platinum selling Hard Rock act Tesla all new single titled "So Divine…". The song is lifted off the forthcoming album "Simplicity" which will be released on Frontiers in Europe on June 6.
Simplicity will be the band's seventh studio full length LP and fifteenth release overall. The new effort will be the follow-up to "Forever More", which was released in October 2008 and featured the single "I Wanna Live."
The new single is available for download and streaming on all digital outlets including iTunes, Amazon, Spotify, Deezer etc.
xx xx
THREE LIONS "HOLD ME DOWN" LYRIC VIDEO:
"Three Lions" is the sensational eponymously titled debut album from this new British 3 piece rock band. The band consists of Vinny Burns (Dare, Ten, Asia) on guitar, Greg Morgan (Dare, Ten) on drums and introduces Nigel Bailey on vocals and bass guitar.
Three Lions' debut features 12 brand new tracks, written by the band and also in collaboration with producer Alessandro Del Vecchio on 2 songs. Recorded at The Viper Room, Coil Tap Studios in the UK and Ivory Tears Studio in Milan, this album combines massive guitar riffs and great hooks alongside driving rhythms and powerful, yet emotional vocals.
The band was formed when Vinny, Greg and Nigel were introduced by Serafino and Alessandro at Firefest in October 2012. The guys hit it off straight away and immediately set about writing new material for the album. The first single, Trouble In A Red Dress, captures the energy of the band and is a classic foot stomping rock song with an infectious groove, soaring guitars and a chorus you have to sing along with.
The album is made up of songs that were written without an agenda. "We set out to write good songs, the only criteria was that all of us liked them" said Nigel, "Working with Vinny and Greg has been a blast and we were all determined to make the best album possible and are immensely proud of the songs that have made it onto the final record". From the eastern influenced Kathmandu, to the driving power of Hellfire Highway and Twisted Soul, to the heartfelt ballads Made For One Another and Don't Let Me Fall. This album delivers passionate performances from the guys. Vinny's trademark guitar work is, as you would expect, filled with emotion and feel. "I wanted to start with a blank canvas for the guitars" says Vinny. "This album allowed me to show a different side to my playing whilst retaining the familiar sound and feel fans of Dare and Ten will recognise". "Working with Vinny again has been great fun and Nigel brings something new to the table" said Greg. "This is definitely a record made by a band, not just a studio project, and that really comes across in the songs. We had an instant connection as musicians but also as people and we cannot wait to get out and perform these songs live soon".
A BRAND ENW BRIAN HOWE CUT:
A new Brian Howe song titled Cut is available for advance purchase now via bandcamp. The track is from the singer's upcoming solo album, the funds from the sale of the single go towards the recording effort.
MITCH LAFON TALKS TO GLENN HUGHES:
In Episode 11 of One On One With Mitch Lafon, Mitch welcomes singer Glenn Hughes who talks about his new band and album, California Breed. The band was formed from the ashes of Hughes' previous outfit Black Country Communion and Glenn addresses the issues faced by that band and why they couldn't tour more often. Glenn also talks about joining forces with upcoming guitarist, Andrew Watt, and his continued work with Jason Bonham. The chat ends with Glenn discussing his need to make and perform new music as well as his involvement with animal shelters. Joining Mitch as co-host this episode is Mark Strigl of the Talking Metal Podcast. www.spreaker.com/user/talkingmetal/one-on-one-with-mitch-lafon-episode-11.
For more about California Breed visit: www.californiabreed.com.
This Episode of One On One With Mitch Lafon is brought to you by the Heavy Montreal Festival taking place August 9th and 10th at Parc Jean Drapeau in Montreal (Quebec) Canada and this year Features performances by Metallica, Slayer, The Offspring, Lamb of God, Twisted Sister and many more! Listen to the One On One With Mitch Lafon Podcast on iTunes & Spreaker. www.twitter.com/1On1WithMitch / www.facebook.com/OneOnOneMitchLafon.
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Night Ranger's New Studio Album "High Road" Confirmed For June Release Via Frontiers Records
Iconic arena-rockers Night Ranger are set to release their new studio album, High Road, on June 6 in Europe and June 10 in North America via label home Frontiers Records. Produced by the band itself, High Road will be available in two formats – a standard CD version and a deluxe version which includes two bonus tracks and a DVD featuring a background look at the making of the album along with video clips. To access the full size cover art for High Road, which incorporates elements of the artwork from the band's previous releases, pleaseclick here and see below for the full track listing.
High Road can be pre-ordered now at Amazon as the Standard Version , and as the High Road (CD/DVD Deluxe Edition) . The album's full track listing can be seen below. Look for the band to tour North America and around the globe this year in support of High Road.
Of the new album, frontman/bassist/songwriter Jack Blades commented, "It's almost summer and a great time to take a trip down the High Road! Our new record features classic Night Ranger feel-good, high-energy kick-ass rock n' roll. We can't wait for our fans to hear."Drummer/singer Kelly Keagy added, "We're so proud of this new record and excited to get back on the road to bring the new music to our fans."
Night Ranger High Road track listing: 1. High Road 2. Knock Knock Never Stop 3. Rollin' On 4. Don't Live Here Any More 5. I'm Coming Home 6. X Generation 7. Only For You Only 8. Hang On 9. St. Bartholomew 10. Brothers 11. L.A. No Name* 12. The Mountain Song* *only available on deluxe edition.
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Top Melodic Rock News On 09/04/2014
GUITAR LEGEND NEAL SCHЦN'S VIDEO "EXOTICA" HAS EXCLUSIVE WORLDWIDE PREMIERE:
Neal Schцn fans can click here to check out the exclusive worldwide premiere of the video for "Exotica" on Vintage Guitar. The psychedelic video, which includes commentary from Schцn, Mendoza and Castronovo, is the first from the forthcoming jazz and blues-inspired hard rock studio album, SO U, and is one of two instrumental tracks from the effort. SO U features Schцn along with bassist Marco Mendoza (Black Star Riders, Ted Nugent, Whitesnake, Thin Lizzy) and drummer Deen Castronovo (Journey, Ozzy Osbourne, Steve Vai, Hardline) splitting vocal and writing duties, with many of the tracks also co-written by Night Ranger/Damn Yankee's songwriter, singer and bassist Jack Blades. SO U will be available on May 16 in Europe and May 19 in North America via Frontiers Records. The album can be pre-ordered now via iTunes, Amazon and via the Journey online store; those who purchase SO U now via iTunes will receive "Exotica" as an instant gratification track.
Best known as founding member and lead guitarist of Journey, Neal Schцn has enjoyed a remarkable career as one of rock n' roll's top virtuosos, with a hand in creating some of the most popular songs of all time. Beginning his career more than 35 years ago in the San Francisco Bay area, the 15-year-old guitar prodigy left home to join Santana. Schцn moved on in 1973 to form Journey. With Journey and other projects, he has earned 19 Top 40 singles and 25 platinum and gold albums, was awarded the prestigious "Legend Of Live Award" at the 2011 Billboard Touring Awards, received a star on the Hollywood Walk of Fame in 2005 and was individually inducted into the Oklahoma Music Hall Of Fame in 2013. As the only member to record on all of Journey's albums, Schцn continues with the band today in its latest incarnation.
In addition to 6 solo albums and 14 studio albums with Journey, Neal Schцn has also performed with Joe Cocker, Sammy Hagar, Paul Rodgers, Larry Graham, Betty Davis, Michael Bolton, fusion legend Jan Hammer, Hardline and supergroup Bad English, as well as a variety of side projects. His latest instrumental solo album, The Calling, released in 2012 via Frontiers Records, won rave reviews from fans and the media alike, with Vintage Guitar declaring "The Calling is a fine piece of work demonstrating that Schцn still has it going on – and then some…The songs are strong and his guitar tones are absolutely luxurious." In demand as one of the leading guitarists of his generation, Schцn also worked with Gibson to manufacture his own limited edition "Neal Schцn Signature Model Custom Les Paul" guitar, but now uses custom PRS Neal Schon LTD Private Stock guitars, made especially for Neal by Paul Reed Smith.
For more information please visit: www.schonmusic.com.
LANEY'S LEGION – POPTASTIC VIDEO AND DIGITAL RELEASE:
The Godfather of Swedish Glam and Sleaze Chris Laney's band Laney's Legion has released the second digital single Poptastic on iTunes, Spotify, Amazon today. The band has also release their first video from the "Self Titled" release. The "Self Titled" full length CD will be released April 22 worldwide. YouTube link: youtu.be/CDbCkk2NPyA.
Laney's Legion features Chris Laney (Zan Clan, Randy Piper's Animal), Rob Marcello (Danger Danger), Mats Vassfjord (Grand Design, Impera) and Patrik Jansson (Helsingland Underground).
How can you be truly unique in music today? Well, it's hard. Many bands focus too much on image, attitude or whatever and forget about the music. At the end of the day, the only thing that matters is the song: The Song Is King! Laney's Legion deliver a debut album full of surprises. Chris Laney has made a name for himself in the hard rock world writing, producing, mixing and winning Grammy awards with bands like Candlemass, Dynazty, Europe and H.E.A.T. After two successful and critically acclaimed solo albums "Pure" (2009) and "Only Come Out At Night" (2010) he's now back with a new album. But instead of returning with a third solo album, the forthcoming full-length feature will be the debut album for his new band: Laney'sLegion. "I really missed the feeling of having a real band. I wanted to go back to the basics", says Chris. Laney is of course still handling lead vocals and rhythm guitars. Joining him is drummer Patrik Jansson (Hellsingland Underground) and bass player Mats Vassfjord (Grand Design, Impera).
They are both sought after session players in the Swedish music circuit, and toured with Laney on his last tours. Last but not least, the brand new quartet is complete with the highly acclaimed guitar virtuoso Rob Marcello (Danger Danger). This time, it's all about the music:"My solo albums were pretty much recorded and written in a rush. This time I didn't wanna stress anything. This time I only wanted the best songs possible". In order to achieve this, he brought in longtime partner Anders Ringman to help out with writing and producing. The multi-platinum songwriting duo, aka Platform, has a 15-year collaboration history featuring work with Crashdпet, Crucified Barbara, Steevi Jaimz and others. "It was the natural choice. We work so well together", Chris says. And with contributions from everybody in the band, Laney's Legion have produced an album containing nothing but solid, melodic sing-along tunes. "We're not trying to reinvent the wheel here. What it all come downs to is the music. And there are surprises. We're not just doing the normal hard glamrock our fans might expect, we rock, we pop and no one can stop us now!"
WebLinks: www.facebook.com/laneyslegion / www.chrislaney.com / www.perrisrecords.com.
RED DRAGON CARTEL ADD UK DATE:
Former Ozzy Osbourne guitarist Jake E. Lee has today announced that his new band Red Dragon Cartel will play The Tivoli, Buckley on Friday June 13 as part of their forthcoming UK Tour. The tour follows Red Dragon Cartel's eponymous debut album, released by Frontiers Records earlier this year. Special guests on all UK dates are Syron Vanes and Jupiter Falls. Red Dragon Cartel will also play Download Festival on Sunday June 15. Their new single "Shout It Out" is out now.
Red Dragon Cartel – June 2014 UK Tour:
London's O2 Academy Islington Friday June 6
Nottingham Rescue Rooms Saturday June 7
Wolverhampton Slade Rooms Sunday June 8
Glasgow Classic Grand Tuesday June 10
Newcastle O2 Academy 2 Wednesday June 11
The Tivoli, Buckley Friday June 13
Download Festival Sunday June 15
THE WILLIE HINES BAND SAYS "WHATEVER":
After Jet Red drifted apart in the early 90's, Willie Hines focused on writing songs that led to his first solo album "Yeahright" in 2000. After several years of trials and tribulations that included some medical issues and dealing with the lovely global economic downturn that we all experienced, Willie Hines has resurfaced with the Willie Hines Band. Their recent release, "Whatever", is a labor of love that was put together over several years culminating in an eclectic 12 song album that emerged as an unofficial "homage" to the rock music and musicians who've inspired Hines since the 1960s.
Hines notes: "I think it's the music that gets you through. No matter how bad a day you have, you get to pick up your guitar. Everybody gets beat down. Life does that. You just pick yourself back up."
Where does one start? The latest release from the Willie Hines Band covers a tremendous amount of territory. If you want pop sensibility, you get it in songs like "Say Hello", "Hippie Chick", and "Downtown". If you want a straight ahead rock tune, then "Boyd's Party" is definitely in the sweet spot along with "Solitare" not far behind. If you want circa Led Zep sound, then "The Drift" is right there with big time nods to the mighty Plant/Page machine. If you want power-pop-rock, then "Smile" is the song that will get you singing the chorus immediately and wanting more! There is not a dull moment of sound on this album.
Much has changed musically since Willie Hines was singing for The Lights and Jet Red but one thing remains constant- Willie Hines continues to bring finely crafted music to those who are willing to find it. With the input of Jeffery Babineau (guitar, backing vocals, and much more!), John Wise (bass, keys, backing vocals), and Michael "Fro" Frowein (drums, backing vocals; ex- George Lynch, Jeff Pilson's War & Peace), the album sparkles with talented musicianship including appearances by Brad Lang (current Y&T bassist, Jet Red) and Steve Brown (drums for Montrose, Oleander, Jet Red).
Will this album make the charts? Not likely due to the state of the fractured music industry today where great talent is overlooked while posers somehow get a seat in the spotlight. Nonetheless, if you are a fan of real music being made by real people, then this album is for you. Rock on!!
Track listing: Say Hello, Solitare, Downtown, The Drift, Honeymoon Junkie, Greta Garbo, Everybody Else, Smile, Gypsy's Gift, Hippie Chick, Boyd's Party, Goodbye.
The CD is available via www.williehinesband.com or Amazon: tinyurl.com/WHB-Whatever.
THE VEER UNION TO RELEASE DELUXE EDITION:
The Veer Union will release the Deluxe Edition of Divide The Blackened Sky which includes three new songs and re-mastered tracks. The album will be released on June 10, 2014 through Pavement Entertainment and distributed by MRI/Sony RED. Frontman Crispin Earl gives us his take on the album, "Divide The Blackened Sky, is a much darker and heavier effort than our previous works. It depicts all the hard times we have been through over the last couple of years".
The band will be supporting this effort with a full tour, with a new single and video "Borderline" featuring (Jonny Hetherington) from the band Art of Dying. The Veer Union was founded in 2004 by singer/songwriter Crispin Earl in Vancouver, Canada. The band made their mark in 2009 with the top 10 hit single "Seasons" off their debut album "Against The Grain", which peaked at #7 and was the longest charting rock song for a new artist that year. It became the theme song for the 2009 Stanley Cup winners, the Pittsburgh Penguins. "Seasons" was also featured in all Major League Baseball postseason telecast as well as NFL, NASCAR, ESPN, WWE, NHL and more.
Look out for a brand new studio album from The Veer Union in 2015.
LabelLink: www.pavementmusic.com.
WILLIAMS/CHAMPLIN/FRIESTEDT UPDATED LIVE IN CONCERT DVD:
TOTO singer Joseph Williams and Bill Champlin formerly of the band Chicago joins forces with renowned guitarist and songwriter Peter Friestedt. Together they did a European Tour in 2012 with an all-star band featuring Bill's wife Tamara Champlin and Herman Matthews – known for his work with Tower Of Power and Kenny Loggins. The tour was a huge success with sold out venues and great reviews. One of the concerts was filmed and recorded, and here we have the magic captured on stage. Bill Champlin is a two time Grammy award winning Artist that is well known for his 28 years with the group Chicago. Bill has appeared on countless of records and is also a founding member of the group Sons Of Champlin. Bill has sung on many major hit songs such as the #1 Billboard song "Look Away".
Joseph Williams is the lead singer of Toto. He is featured on the hit albums "Fahrenheit" (1986) and "The Seventh One" (1988). He has also written extensively for films and been a session singer. He can also be heard on the blockbuster soundtrack to Disney's "The Lion King" where he is the singing voice of the adult Simba with songs like "Hakuna Matata" and "Can You Feel The Love Tonight".
Guitarist, composer, producer and major-label artist Peter Frienstedt has released two own acclaimed albums "LA Project" (2002) and "LA Project II" (2008). The album received top reviews and was called 'best Westcoast records in years. "Peter has recently toured with Chicago singer Bill Champlin, Joseph Williams and Artist Michael Ruff. In 2011 Peter and Joseph Williams released the Top charting and critically acclaimed album Williams/Friestedt.
The Japanese DVD release of this concert features an improved footage edit and a Bonus track – Tamara Champlin's You wont get to heaven alive.
LIVE4AOR, TRUE METAL & IZKAR PRODUCCIONES PRESENT: A HARD ROCK NIGHT FESTIVAL 2014 SPAIN:
Live4aor, True Metal & Izkar Producciones Present: A Hard Rock Night Festival 2014 Spain featuring the following bands:
23rd. May Madrid Sala We Rock
Grand Design (Sweden), Degreed (Sweden), Airless (Spa), Tokio (Spa), Bon Vivant (Spa) Tickets: www.ticketea.com/a-hard-rock-night-madrid/
24th May Zaragoza La Casa del Loco
Grand Design (Sweden), Degreed (Sweden), Airless (Spa), Hardreams (Spa), Bon Vivant (Spa) Tickets: www.ticketea.com/a-hard-rock-night-zaragoza/
Info: www.facebook.com/events/216173171906613/
CAPTAIN BLACK BEARD REVEAL BEFORE PLASTIC:
Dead End Exit Records (a division of RoastingHouse) will the new Captain Black Beard album Before Plastic on May 23. The video clip for the track "Somebody" can be found here: youtu.be/vtHXEnYSN4U.
Captain Black Beard made it's live debut on the 31st of October 2009 and has since been playing most of the clubs in Stockholm. At the end of 2010 the band decided to pick it up a notch and record a full length album. Having been in talks with the biggest rock producers in Sweden – Chips Kiesbye (Sator, The Hellacopters), Tobias Lindell (Europe, Mustasch), Patrik Frisk (Takida, Corroded) – the band chose to work with David Castillo (Opeth, Katatonia) who had already shown himself capable when working on the bands single "Rock Is My Life". The completion of the CD was celebrated together with hundreds of friends and fans at Gцta Kдllare in Stockholm on the 28th of May, 2011. In the fall the band made their first concerts abroad as they did a short tour of the U.S.
Captain Black Beard's debut CD has been hailed in the press with tons of great reviews all over the world, from Australia to Brazil, in magazines such as Classic Rock, Classic Rock AOR, Sweden Rock, Fireworks, Power Play, Black Velvet and Red Hot Rock. It was also named one of the "Albums Of The Year So Far" by legendary journalist Geoff Barton of Classic Rock. 2012 saw the band playing in the U.K. for the first time, headlining Summer Nights Rock Fest and gearing up for the next album, among other things.
Most of 2013 has been dedicated to the making of the bands second album, and they signed a deal with Dead End Exit Records in the beginning of 2014. "Before Plastic" will be released in May 2014 with lots of live performances to follow.
Line-up: Sakaria Bjцrklund – vocals/guitar, Victor Hцgberg – drums, Robert Majd – bass, Christian Ek – guitar
Guest guitar solos: Bruce Kulick (Kiss), Mats Karlsson (220 Volt, The Summit)
Tracks: 01 – Please Come Home, 02 – Somebody, 03 – New York City, 04 – Bad Girl, 05 – Music Man, 06 – Aiming For Love, 07 – Keep On Drivin', 08 – Shout, 09 – Life's What You Make It, 10 – Takin' You Out, 11 – Listen Up.
"Captain Black Beard have guts and glory written all over them. Their melodic vocals and guitars, make them stand out above the rest in the genre of AOR Rock". Bruce Kulick (Kiss)
"Ill-mannered and charming hitseeking rock like it was made by KISS, Billy Idol and Pat Benatar – together and in their prime." Sweden Rock Magazine (rating 8/10)
WebLink: www.captainblackbeard.net.
REBELLIOUS SPIRIT PREP SECOND ALBUM:
Rebellious Spirit will release a new studio album in September 2014. Support slot on the second leg of the Axel Rudi Pell European Tour also confirmed.
The german Hard Rock newcomer Rebellious Spirit will enter the studio in May/June to record their new studio album. It will be released in September 2014 directly for the start of the second part of the Axel Rudi Pell Tour, where Rebellious Spirit will be the special guest again. Stay tuned for more info about the new album. On the first part of the Axel Rudi Pell-Tour in February the four young hopefuls got great reactions which you can see in a video here: www.youtube.com/watch?v=hWK1HbhrM_Y.
Rebellious Spirit live 2014:
19.04. CH-Uster – Star Club
26.04. D-Villingen-Schwenningen – K3
14.06. D-Schmittweiler – Rock am Bunker
04.07. D-Euro Run 2014 – Gremium MC World
06.09. D-Gruol – Motorradtreffen
02.10. D-Metzingen – Stadthalle
Rebellious Spirit as special guest on the Axel Rudi Pell-Tour:
"Into The Storm"-Tour 2014 Part 2 Axel Rudi Pell special guests: Rebellious Spirit
19.09. CH-Pratteln – Z7
20.09. NL-Zoetermeer – Boerderij
21.09. D-Cologne – Essigfabrik
23.09. D-Aschaffenburg – Colos-Saal
24.09. D-Munich – Backstage
26.09. A-Vienna – Szene
27.09. CZ-Zlin – Masters of Rock Cafe
28.09. CZ-Prague – Matrix Music Club
30.09. D-Berlin – Huxleys
01.10. D-Bremen – Aladin
03.10. D-Karlsruhe – Substage
04.10. B-Vooselaar – Biebob
05.10. D-Bochum – Zeche
Ticket-Hotline Germany: METALTIX +49-(0)4627/183838, www.metaltix.de Touragency: Continental Concerts
WebLinks: www.rebelliousspirit.de / www.spv.de.
NEW FROM INTHESTUDIO: THE STORIES BEHIND HISTORY'S GREATEST ROCK BANDS:
Dallas, TX – April 8, 2014. North American syndicated Rock radio show and website InTheStudio: The Stories Behind History's Greatest Rock Bands celebrates the 40th anniversary of Lynyrd Skynyrd's career-breaking 1974 classic Second Helping.
Lynyrd Skynyrd was a welcome dose of danger in a musical scene gone soft by the early '70s. The Lynyrd Skynyrd legend inevitably circles back to their first album Pronounced and the epic "Free Bird", but the April 1974 follow-up Second Helping is the incredibly strong album which busted the band wide open, producing the rebel singalong Top 10 hit "Sweet Home Alabama" and a stack of southern rock classics including "Don't Ask Me No Questions", "Workin' for MCA", "The Needle and the Spoon", their definitive version of the late J.J. Cale's "Call Me the Breeze", and two songs unlike anything on the first album, "The Ballad of Curtis Loew" and the achingly bluesy "I Need You".
Original guitarists Gary Rossington and Ed King tell the story of the Jacksonville, Florida "band of brothers" with nothing but dreams, making it big and spreading the love of Southern Rock across to the globe. Gary Rossington sums up, to InTheStudio host Redbeard, what Rossington believes was the secret to Lynyrd Skynyrd's musical identity.
"In those days it was the Alice Coopers and Kisses and all the make-up. That's who was making it. We were kinda REAL. We wore blue jeans and T-shirts. Our music was our gimmick."
This program also contains Skynyrd bassist the late Leon Wilkeson's final national radio interview. Lynyrd Skynyrd 'Second Helping' /InTheStudio interview is available now to Stream at: www.inthestudio.net/redbeards-blog/lynyrd-skynyrd-second-helping-40th-anniversary-gary-rossingtoned-king.
(Dallas, TX) – InTheStudio.NET, the web home for North American syndicated rock radio show InTheStudio: The Stories Behind History's Greatest Rock Bands celebrates the 40th anniversary of Aerosmith's second album Get Your Wings. New England quintet Aerosmith hatched in January 1973 with their self-titled album, but it wouldn't be until the release of their sophomore effort Get Your Wings in Spring 1974 that Aerosmith would take off by defining the sound that would soon become America's premiere hard rock band.
For Get Your Wings, Aerosmith enlisted the talents of producer Jack Douglas, whose crystal clear production provided a much needed boost sonically, as proof on the Aerosmith classics "Same Old Song and Dance", "Lord of the Thighs", "S.O.S. (Too Bad)", "Seasons of Wither", "Pandora's Box" and the all important matrix that gave New Yorker Steven Tyler common ground with New Hampshire boys Joe Perry and Tom Hamilton, The Yardbirds' "Train Kept A Rollin' ".
It is the solid bottom end provided by drummer Joey Kramer and bassist Tom Hamilton with Joe Perry's stiletto guitar licks a top the weaving three dimensional rhythm guitar play of Brad Whitford that makes Aerosmith's instrumentation so alluring. Steven Tyler's distinctive voice seduces the ears of listeners, and together the band would explode a mere album later with Toys In The Attic.
Joey Kramer tells InTheStudio host Redbeard how the hard work put into the band in those early years has been the reason Aerosmith's sound remains timeless today.
"An album like this (Get Your Wings) is what it is because of how it was made, and the amount of time that was spent on those songs and recording this record is the reason … why it will stand up ten years from now."
Stream the complete Aerosmith program as part of InTheStudio's Medium Rare "online-only" rockumentary series www.inthestudio.net/online-only-interviews/aerosmith-get-wings-40th-steven-tyler-joe-perry-tom-hamilton
Dallas, TX – April 1, 2014. North American syndicated Rock radio show and website InTheStudio: The Stories Behind History's Greatest Rock Bands celebrates the 'Best of' KISS on the eve of their induction into the Rock & Roll Hall of Fame. There are a flurry of new developments in the now forty year saga of KISS,including new catalog albums being released, a 40th anniversary tour starting this Summer, and finally the long-awaited induction into the Rock and Roll Hall of Fame. Regardless of whether you think the frottage foursome are rock gods or demons doesn't change the fact that KISS have been, and continue to be, enormously successful. Selling over 100 million albums, KISS together with their music, make-up, and elaborate stage show pioneered a generation of outsized arena rock.
Unfortunately, KISS is not the first Hall of Fame inductee to weather controversy regarding personnel changes over a four decade career. Bassist/singer Gene Simmons speaks frankly to InTheStudio host Redbeard about the work ethos of KISS.
"We never bought into the 'I want to get high and stoned and just get up on stage and do whatever the hell.'.. We're closer to an Olympic team. We take it deadly seriously. Being in KISS in not a birthright. It's a privilege."
Singer/guitarist Paul Stanley states: "God knows we make mistakes, but that's the beauty of KISS. We do things the way we see fit, and we live and die by the sword."
Gene and Paul discuss their earliest musical influences, the state of music today, and chronicle some important KISS career highlights in this hour long radio special. KISS 'Best of/ Rock Hall Induction' /InTheStudio interview is available now to Stream at:www.inthestudio.net/redbeards-blog/kiss-best-of-rock-roll-hall-fame-paul-stanley-gene-simmons/
Hot News	Aerosmith, album, aor, Axel Rudi Pell, best, Betty Davis, Bill Champlin, Billy Idol, BLACK STAR RIDERS, Chicago singer Bill Champlin, Chris Laney, classic rock, Danger Danger, Deen Castronovo, eponymous debut album, European tour, fresh, Frontiers Records, full length album, Gary Rossington, glam rock, Greta Garbo, hard rock, heavy metal, hits, Hollywood Walk of Fame, hot, instrumental solo album, Jan Hammer, Joe Cocker, Joseph Williams, Kenny Loggins, KISS, Laney's Legion, Les Paul, Lynyrd Skynyrd, Major League Baseball, Marco Mendoza, Mats Vassfjord, melodic rock, metal, Michael Bolton, music, Neal Schon, news, North America, North American syndicated Rock radio show, Ozzy Osbourne, Pat Benatar, Patrik Jansson, Paul Rodgers, Paul Stanley, Peter Frienstedt, Pittsburgh Penguins, Red Hot Rock, rock, Rock and Roll Hall of Fame, Sammy Hagar, Sons Of Champlin, Steve Brown, Steve Vai, Steven Tyler, studio album, Sweden Rock, Tamara Champlin, Ted Nugent, The Lion King, The Veer Union, Thin Lizzy, Tower Of Power, Willie Hines, Willie Hines Band	0 Comments
Queen + Adam Lambert Announce 2014 North American Tour
As we hinted last week, Queen and Adam Lambert will tour North America this summer. The complete list of dates can be found below.
Lambert, Brian May, Roger Taylor and supporting musicians will play 19 dates over the course of a month beginning June 19 at Chicago's United Center. They will have hit major venues in 18 cities (Las Vegas gets two shows) across the United States and Canada by the time they wind it up on July 20 at Merriweather Post Pavilion in Columbia, Md., which is located between Washington, D.C. and Baltimore.
"I'm completely in awe of the Queen phenomenon," Lambert said via press release. "The thought of sharing the stage for a full set in North America is so beautifully surreal. I'm honored to be able to pay my respects to Freddie's memory; he's a personal hero of mine, and I am deeply grateful for the chance to sing such powerful music for fans of this legendary band. I know this tour will be a huge milestone for me, and with the support of Brian, Roger and the rest of the band, I feel like magic will be on display."
"Let's rock those beautiful arenas just one more time," May added.
Tickets go on sale March 14 at Livenation.com and through their mobile platforms. American Express card members will have access to a pre-sale beginning March 10 at 10:00AM for the U.S. dates and March 11 at 10:00AM for the Canada dates.
Queen + Adam Lambert 2014 North American Tour
6/19 — Chicago, Ill.
6/21 — Winnipeg, Manitoba
6/23 — Saskatoon, Saskatchewan
6/24 — Edmonton, Alberta
6/26 — Calgary, Alberta
6/28 — Vancouver, British Columbia
7/1 — San Jose, Calif.
7/3 — Los Angeles, Calif.
7/5 — Las Vegas, Nev.
7/9 — Houston, Texas
7/10 — Dallas, Texas
7/12 — Detroit, Mich.
7/13 — Toronto, Ontario
7/14 — Montreal, Quebec
7/16 — Philadelphia, Pa.
7/17 — New York, N.Y.
7/19 — Uncasville, Ct.
7/20 — Columbia, Md.
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Asia – Valkyrie – Official Video / New Studio Album
Asia Gravitas – Release date March 21 (Europe) / March 25 (North America). Order on iTunes: smarturl.it/GravitasiTunes and Amazon: Gravitas (Reg) or Gravitas CD/DVD (Deluxe). Plus – new Frontiers promo spot.
Hot News	album, Amazon, aor, Asia Gravitas, best, classic rock, fresh, glam rock, Gravitas, hard rock, heavy metal, hits, hot, melodic rock, metal, music, news, North America, rock	0 Comments


The National Australia Bank has been Peet's principal banker since 1895 – a partnership of more than 125 years that, through innovation, is helping Australians realise their dream of home ownership.
Peet has always been committed to delivering housing that is both affordable and sustainable. The flexible and innovative approach by NAB to debt funding has enabled Peet to continually acquire and develop land and to release products to market in the style, timeframe and cost that meets customer demand.
In the early days of Peet, basic terms of sale were a two pound deposit and monthly repayments of a pound with no interest! Over the past 125 years, the property sector has changed substantially as the country has grown and new technologies and innovations have shaped the Australian way of life.
A few years ago, NAB and Peet pre-empted the tightening of the credit cycle and were proactive in accessing capital markets to be more in control of the company's funding.
Today, Peet accesses the corporate bond market which has enabled the company to develop and grow its business model.
The NAB relationship has been critical for Peet in achieving its ongoing acquisition strategy – whether it is an outright acquisition, joint venture or funds management – NAB understands that one size doesn't fit all with debt funding.


I like the consistent lines and colors of the tables and chairs contrasted with the captured movement of the card players. Nice foray into people pictures!
Woot! Thanks Johanna. It's a bit more challenging.
Cool! 🙂 Love this. Thanks and blessings.


text:
Requirement of Translation But Not Transcription for the Maintenance of Long-Term Depression in the CA1 Region of Freely Moving Rats
Denise Manahan-Vaughan, Alexander Kulla and J. Uwe Frey
Journal of Neuroscience 15 November 2000, 20 (22) 8572-8576; DOI: https://doi.org/10.1523/JNEUROSCI.20-22-08572.2000
Denise Manahan-Vaughan
1Johannes Mueller Institute for Physiology, Synaptic Plasticity Research Group, Humboldt University Medical Faculty (Charité), D-10115 Berlin, Germany, and
Alexander Kulla
J. Uwe Frey
2Leibniz Institute for Neurobiology, Department of Neurophysiology, D-39008 Magdeburg, Germany
Hippocampal long-term depression (LTD) comprises a persistent reduction in synaptic strength that can be induced in the CA1 region by repeated low-frequency stimulation (LFS). Previous studies have demonstrated that hippocampal long-term potentiation requires de novo protein synthesis. Whether hippocampal LTD is also protein synthesis-dependent is not known. In this study, we investigated if the previous administration of translation inhibitors (anisomycin or emetine) or a transcription inhibitor (actinomycin-D) influenced the profile of LTD in freely moving adult Wistar rats. Seven- to 8-week-old animals underwent chronic implantation of a recording electrode in the CA1 stratum radiatum and a stimulation electrode in the Schaffer collateral/commissural fiber pathway. A cannula was implanted in the ipsilateral cerebral ventricle to enable drug administration. Experiments were commenced 10 d after the implantation procedure. Immediately after application of LFS (1 Hz, 900 pulses) robust LTD was seen that persisted for >8 hr in control animals. Application of anisomycin (240 μg/5 μl) emetine (240 μg/5 μl) before LFS prevented the expression of LTD or ∼4.5 hr after LFS. Previous administration of actinomycin D (72 μg/12 μl) had no effect on the expression of LTD. None of the compounds elicited significant effects on basal synaptic transmission when administered in the absence of LFS. These data suggest that LTD in the CA1 region in vivo is protein synthesis-dependent. Furthermore, persistent LTD can be established through the translation of existing mRNA, whereas de novo mRNA transcription does not appear to be necessary.
actinomycin D
anisomycin
long-term depression
Wistar
Hippocampal long-term depression (LTD) comprises a persistent functional decrease in synaptic transmission that occurs as a consequence of patterned stimulation of afferent fibers (Bear and Malenka, 1994). As is the case with hippocampal long-term potentiation (LTP), it is dependent on intracellular calcium mobilization, through for example, calcium entry via NMDA receptor channels (Dudek and Bear, 1992; Mulkey and Malenka, 1992) and activation of metabotropic glutamate receptors (mGluRs) (Huang et al., 1997; Manahan-Vaughan, 1997). The relative intracellular concentration of calcium is likely to be a crucial determinant of the form of synaptic plasticity subsequently expressed (Artola and Singer, 1993).
It has been suggested that the mechanisms underlying LTD expression, in conjunction with the mechanisms of LTP, are responsible for information storage by the hippocampus (Bear, 1996). Furthermore, hippocampal LTP and LTD may be associated with specific forms of explicit memory in the cerebral cortex. It has been demonstrated that distinct hippocampus-associated memory storage occurs in phases (Grecksch and Matthies, 1980; Grecksch et al., 1980). This has also shown to be the case with regard to hippocampal LTP, in which late LTP can be dissociated from short-term potentiation (STP) (which lasts for minutes) and early LTP (which lasts for up to 4 hr) by means of protein synthesis inhibitors or inhibitors of protein kinase A (Krug et al., 1984; Frey et al., 1988, 1993, 1996; Otani et al., 1989; Matthies et al., 1990). Recently, hippocampal LTD, which endures for many days, has been demonstrated in freely moving rats (Manahan-Vaughan and Braunewell, 1999). This form of LTD also exists in phases: an NMDA receptor-dependent phase of short-term depression (STD), which lasts for ∼1 hr, and an mGluR-dependent phase, which becomes evident immediately after the NMDA receptor phase and which might resemble the stage of early LTP (Manahan-Vaughan, 1997).
Information storage in the form of a long-term reduction in synaptic plasticity may be accompanied by protein synthesis-dependent synaptic modifications. First, indications that the maintenance of LTD may depend on protein synthesis came from studies in the cerebellum, in which the application of protein synthesis inhibitors prevented late LTD (Linden, 1996; Levenes et al., 1998). Whether hippocampal LTD also has a protein synthesis-dependent phase has not been established to date. This study therefore set about to examine whether inhibitors of mRNA translation and transcription influence the expression of hippocampal LTD in freely moving rats.
Surgical preparation. Seven- to 8-week-old male Wistar rats were prepared as described previously (Manahan-Vaughan, 1997). Briefly, under sodium pentobarbitone anesthesia (Nembutal; 40 mg/kg, i.p.), animals underwent implantation of a monopolar recording and a bipolar stimulating electrode (made from 0.1 mm diameter Teflon-coated stainless steel wire). A drill hole was made (1-mm-diameter) for the recording electrode (2.8 mm posterior to bregma, 1.8 mm lateral to the midline), and a second drill hole (1 mm diameter, 3.1 mm posterior to bregma, 3.1 mm lateral to the midline) was made for the stimulating electrodes (coordinates based on Paxinos and Watson, 1986). The dura was pierced through both holes, and the recording and stimulating electrodes were lowered into the CA1 stratum radiatum and the Schaffer collaterals, respectively. Recordings of evoked field potentials via the implanted electrodes were taken throughout surgery. A cannula was implanted in the lateral cerebral ventricle (0.08 mm posterior to bregma; midline: 1.6 mm lateral to the midline). Once verification of the location of the electrodes was complete, the entire assembly was sealed and fixed to the skull with dental acrylic (Paladur; Heraeus Kulzer, GmbH, Wehrheim, Germany). The animals were allowed 10 d to recover from surgery before experiments were conducted. Twenty-four hours before the commencement of the experiments, animals were placed in the recording chamber withad libitum access to food and water, to allow familiarization to occur. Throughout the experiments the animals could move freely within the recording chamber (40 × 40 × 40 cm), as the implanted electrodes were connected by a flexible cable and swivel connector to the stimulation unit and amplifier. Aside from the insertion of the connector cable and injection cannula at the start of the experiment, disturbance of the animals was kept to an absolute minimum. Throughout the experiments the electroencephalogram of each animal was continuously monitored.
Measurement of evoked potentials. The field EPSP (fEPSP) slope was used as a measure of excitatory synaptic transmission in the CA1 region. To obtain these measurements, an evoked response was generated in the stratum radiatum by stimulating at low frequency (0.025 Hz) with single biphasic square wave pulses of 0.1 msec duration per half wave, generated by a constant current isolation unit. For each time point measured during the experiments, five records of evoked responses were averaged. fEPSP was measured as the maximal slope through the five steepest points obtained on the first negative deflection of the potential. By means of input–output curve determination, the maximum fEPSP was found, and during experiments all potentials used as baseline criteria were evoked at a stimulus intensity that produced 40% of this maximum. LTD was induced by low-frequency stimulation (LFS) at 1 Hz (900 pulses). Only fEPSPs in which 40% of the input–output maximum could be evoked using a stimulation intensity of ≤150 μA were used for this study. If the fEPSPs fulfilled this criterion, LTD was consistently evoked throughout the experiments. Ambient conditions were kept constant to prevent environmental influences on behavioral state that might affect the LTD expressed (Manahan-Vaughan and Braunewell, 1999; Manahan-Vaughan, 2000a).
Compounds and drug treatment. For injection, anisomycin and emetine (2.4 mg; Sigma-Aldrich) were first dissolved in 15 μl of HCl solution (1 N) and then treated with 1 N NaOH to create a pH of 7.0. The solutions were subsequently made up to a 50 μl volume with 0.9% sodium chloride. The animal was injected with 5 μl of this solution (240 μg) over a 6 min period via a Hamilton syringe. Actinomycin-D (Sigma-Aldrich) was fully dissolved in 0.9% sodium chloride. A pH of 7.0 was established using 1 N NaOH. The total amount injected was 72 μg/12 μl over a 6 min injection duration. Throughout the experiments, drugs or vehicle were applied into the lateral cerebral ventricle via an injection cannula that was inserted through the surgically implanted outer cannula. In all experiments, drug or vehicle injection was administered after the observation of basal synaptic transmission for 30 min. Two hours later LFS was applied. Evoked responses were then monitored for a further 8 hr. In case of control experiments in which no LFS was given, evoked responses were monitored for a total of 10 hr after drug or vehicle injection.
Data analysis. The baseline fEPSP data were obtained by averaging the response to stimulation of the Schaffer collaterals, to obtain five sweeps at 40 sec intervals, every 5 min over a period of 30 min. Drug or vehicle injections were then applied, and three further measurements at 5 min intervals were taken, followed by recordings at 15 min intervals for 2 hr. At this point LFS was given, and three measurements at 5 min intervals were then taken and followed by recordings at 15 min intervals for 8 hr. The same protocol for observation of evoked potentials was followed in which no LFS was given. The data were then expressed as mean percentage of preinjection baseline fEPSP reading ± SEM. Statistical significance was estimated using the Mann–Whitney U test. The probability level interpreted as statistically significant was *p< 0.05.
Hippocampal long-term depression in freely moving rats requires protein translation
When LFS (900 pulses at 1 Hz) was applied via the Schaffer collateral- commissural pathway to the stratum radiatum of the CA1 region, an LTD of the fEPSP was generated that was still present 8 hr after LFS was given (data not shown). No change in the profile of LTD was seen when a vehicle injection was applied 2 hr before LFS via a cannula implanted in the lateral cerebral ventricle (n= 6; Fig. 1A). The fEPSP 5 min after LFS was 42 ± 6% of preinjection fEPSP baseline values, and LTD was still present after 8 hr. This type of LTD has been shown to persist of over 7 d in this rat strain (Manahan-Vaughan and Braunewell, 1999).
LTD in the CA1 region in vivo is dependent on protein translation. A, A low-frequency train (LFS) in the presence of a vehicle injection (n = 6) results in a robust LTD that persists for >8 hr. Injection of the protein translation inhibitors anisomycin (240 μg/5 μl; n = 10) or emetine (240 μg/5 μl;n = 7) 2 hr before LFS completely inhibits the expression of LTD from ∼4.5 hr after LFS. B,Anisomycin (240 μg/5 μl; n = 6) or emetine (240 μg/5 μl; n = 7) have no effect on basal synaptic transmission compared to vehicle-injected controls (n = 6). C, Original analog traces showing evoked responses in the CA1 region at three time points: preinjection, t = 5 min and t = 8 hr after LFS, in (i) a vehicle-injected animal and (ii) an animal injected with anisomycin (240 μg/5 μl). Calibration: 5 msec, 5 mV. Line breaks indicate change in time scale.
The involvement of protein translation in the induction of hippocampal LTD in vivo was examined using the reversible translation inhibitor anisomycin, and emetine. When anisomycin was applied 2 hr before LFS, in a concentration that effectively blocked LTP in vivo (240 μg/5 μl injection volume; data not shown), a significant inhibition of LTD occurred (Fig. 1A). Five minutes after LFS, the fEPSP in the anisomycin group was 48.8 ± 4.54% of preinjection fEPSP baseline values (n = 10). This depression was maintained until t = 270 min after LFS when a significant recovery of fEPSP values in the anisomycin group was noted. Thus, at t = 270 min after LFS, the values of the control group were statistically different when compared with anisomycin-treated animals (60.8 ± 5.99% vs 91.7 ± 9.52% (U test, p < 0.05).
The same concentration of anisomycin (240 μg/5 μl injection volume;n = 6) had no significant effect on hippocampal basal synaptic transmission when compared to vehicle-treated control animals (n = 6; Fig. 1B).
When emetine was administered 2 hr before LFS, in a concentration which was reported to significantly block hippocampal LTP in vivo(240 μg; Otani et al., 1989), a significant inhibition of LTD occurred that was similar to that seen with anisomycin (Fig.1A). Five minutes after LFS, the fEPSP in the emetine group was 54.9 ± 3.74% of pre-injection fEPSP baseline values (n = 7). This depression was maintained untilt = 255 min after LFS when a significant recovery of fEPSP values in the emetine group was observed. Thus, att = 255 min after LFS, the values of the emetine-treated group (90.8 ± 3.77%) were statistically different when compared to controls (67.8 ± 4.64%;n = 6; U test, p < 0.05).
Emetine (240 μg/5 μl injection volume; n = 7) had no significant effect, however, on hippocampal basal synaptic transmission when compared to vehicle-treated control animals (n = 6; Fig. 1B).
Hippocampal long-term depression in freely moving rats does not require transcription
To investigate the involvement of transcription in hippocampal LTDin vivo, the transcription inhibitor actinomycin-D was used. This concentration significantly inhibits hippocampal late LTP in vivo with regard to population spike amplitude (whereas fEPSP slope remains largely unchanged) (Frey et al., 1996). Furthermore,Otani et al. (1989) demonstrated a 95% inhibition of hippocampal mRNA synthesis when 60 μg of actinomycin-D was injected into the lateral cerebral ventricle. Thus, an effective inhibition of transcription can be expected at the higher dose, 72 μg, used in our study.
When actinomycin-D (72 μg/12 μl injection volume) was administered 2 hr before LFS, no significant modification of the profile of LTD occurred (Fig. 2A). Five minutes after LFS fEPSP values were 38.8 ± 6.47% of preinjection fEPSP baseline values in controls (n = 6) and 46.3 ± 6.52% in actinomycin-D-treated animals (n = 6). Eight hours after administration of LFS, fEPSP values were 59.5 ± 3.22% and 61.8 ± 4.23% in vehicle- and actinomycin-treated animals, respectively.
LTD in the CA1 region in vivo is not dependent on transcription. A, A low-frequency train (LFS) in the presence of vehicle (n= 6) results in a robust LTD that persists for >8 hr. Injection of the protein transcription inhibitor actinomycin-D (72 μg/12 μl;n = 6) 2 hr before LFS has no effect on the expression of LTD compared to vehicle-treated animals.B, Actinomycin-D (72 μg/12 μl; n= 6) has no effect on basal synaptic transmission compared to vehicle-injected controls (n = 6).C, Original analog traces showing evoked responses in the CA1 region at three time points: preinjection,t = 5 min and t = 8 hr after LFS, in (i) a vehicle-injected animal and (ii) an animal injected with actinomycin-D (72 μg/12 μl; n = 6). Calibration: 5 msec, 5 mV.Line breaks indicate change in time scale.
The same concentration of actinomycin (72 μg/12 μl injection volume) had no effect on hippocampal basal synaptic transmission when compared to vehicle-treated control animals (Fig.2B).
The data from this study support the hypothesis that LTD in the CA1 region of freely moving rats is dependent on protein synthesis. Furthermore, the protein synthesis concerned appears to be performed using existing mRNA, whereas transcription of new mRNA does not appear to be necessary for the time period investigated (8 hr). The possibility that the transcription and translation inhibitors used had toxic effects within the experimental time course studied can be minimized because no significant effect on basal synaptic transmission elicited by test-pulse stimulation was noted for either anisomycin, emetine, or actinomycin-D. However, subtle unspecific effects, which are not expressed as immediate changes of electrophysiological responses, cannot be excluded.
Interestingly, as is the case with hippocampal LTP, LTD appears to be characterized by distinct phases that mechanistically mirror those described for memory formation in mammals (Matthies et al., 1990). Thus, together with the previously described NMDA receptor and mGluR-dependent STD (Dudek and Bear 1992; Mulkey and Malenka, 1992;Huang et al., 1997; Manahan-Vaughan, 1997, 1998, 2000b), which is associated with subsequent activation of calcium calmodulin kinase II, activation of calcineurin, and disinhibition of protein phosphatase 1 (Bear and Malenka, 1994), hippocampal LTD is also accompanied by a protein synthesis-dependent phase that becomes evident ∼4 hr after LFS. Given NMDA receptor-dependent kinase regulation (Norman et al., 2000) and the mGluR-dependent involvement of protein kinase A, C (Kameyama et al., 1998; Huang et al., 1999a,b), and G (Wu et al., 1998) in hippocampal LTD, together with the reported requirement of kinases such as protein kinase A for protein synthesis in other forms of hippocampal plasticity (Frey et al., 1993; Nayak et al., 1998), it is quite possible that these LTD phases are interrelated. Recently, it was shown that the chemical induction of CA1 LTD in vitro by application of a group I mGluR agonist depends on protein synthesis in the form of mRNA translation (Huber et al., 2000). LFS-induced CA1 LTDin vivo is dependent on mGluR activation (Manahan-Vaughan, 1997), suggesting a further link in these processes.
Hippocampal LTD, as determined by changes in fEPSP, i.e., the synaptic response, does not appear to require de novo RNA synthesis. Thus, application of actinomycin-D did not alter the profile of LTD subsequently expressed. Within the present study a comparison was not made with the effectiveness of actinomycin-D in blocking CA1 LTPin vivo. Thus, one cannot rule out the possibility that the failure of actinomycin-D to block LTD arose as a result of insufficient drug concentration. However, Otani et al. (1989) reported a 95% inhibition of hippocampal mRNA synthesis when 60 μg of actinomycin-D was injected into the rat lateral cerebral ventricle. Thus, an effective inhibition of transcription should be expected at the higher dose, 72 μg, used in the present study. Interestingly, our data are in accordance with our earlier report showing that LTP in the CA1 region, if determined by changes in fEPSP responses, seems not to require transcription during the first 8 hr after LTP induction (Frey et al., 1996). This finding indicates that LTD and LTP may use common mechanisms for consolidation. However, the latter results are in contrast to similar experiments in the hippocampal CA1 in which the application of mRNA synthesis inhibitors blocked the induction of late LTP when also measured as changes in fEPSP responses (Nguyen et al., 1994). These contradictory findings could be attributable to nonspecific effects of actinomycin-D caused by the presence of the drug during induction of LTP in the latter in vitroexperiments.
The finding that transcription-dependent protein synthesis is not required for LTD in vivo suggests, however, that mRNA that is already present within the dendrite of the activated synapses is used to encode the proteins that enable persistent LTD. Dendritic protein synthesis has been described for hippocampal neurons (Steward, 1994, 1997). Furthermore, mRNA has been localized at the base of hippocampal dendritic spines (Steward and Levy, 1982; Kleiman et al., 1990; Martone et al., 1996; Tiedge and Brosus, 1996). Recently, chemical induction of CA1 LTD via a group I metabotropic glutamate receptor agonist was shown to depend on dendritic mRNA (Huber et al., 2000). Thus, the possibility that hippocampal LTD uses local mRNA for protein synthesis exists. Indeed, mRNA for proteins that are postulated to play a role in LTD have been identified near dendritic spines, such as certain subunits for the glutamate receptor and αCAMkinase II (Steward, 1997).
It cannot be ruled out of course, that proteins essential for LTD are synthesized either in the soma and then transported along the dendrite to the activated target synapses, or synthesized in specific dendritic compartments that are relatively far away from the activated synapse. A corollary of this is the possibility that a synaptic tag (Frey and Morris, 1997, 1998) is involved in the consolidation of LTD. It has already been demonstrated for hippocampal LTP that synapses activated by tetanic stimulation can recruit proteins, whose synthesis has been initiated at other sites within the neuron, and thereby enable stabilization of long-term potentiation. A similar mechanism may be used in LTD. Translation of mRNA at the soma could then result in protein transport through the neuron that would then be sequestered by the synapses that were activated by LFS.
Recently it was demonstrated that hippocampal LTD may be associated with novelty acquisition and recognition in rats (Manahan-Vaughan and Braunewell, 1999), this finding adds weight to earlier postulations that hippocampal LTD may be associated with learning and memory in mammals (Bear, 1996; Bear and Abraham, 1996). Given existing evidence for a role for protein synthesis in hippocampus-based learning phenomena (Grecksch and Matthies, 1980; Grecksch et al., 1980; Mizumori et al., 1985; Quevedo et al., 1999), these findings, together with the current data supporting the involvement of protein synthesis in LTD consolidation, prompt a revision in current thinking that favors LTP as the cellular basis of learning and memory. Rather it may be the case that both forms of synaptic plasticity serve different forms of learning and memory.
In conclusion, the current data show that, as is the case with LTP, LTD in the CA1 region of freely moving rats is protein synthesis-dependent. Transcription of new mRNA is apparently not necessary for LTD consolidation within the first 8 hr after its induction, rather existing mRNA is translated to create the proteins required. These data offer the first evidence to demonstrate a role for protein synthesis in hippocampal LTD, and given the role of protein synthesis in learning and memory phenomena, point to a significant involvement of this form of synaptic plasticity in information storage in the mammalian brain.
This work was supported by Deutsche Forschungsgemeinschaft Grant SFB 515/B8 to D.M.-V. We acknowledge the back-up support of Ms. S. Vieweg, Dr. K.-H Braunewell, and Ms. K. Schuetz.
Correspondence should be addressed to Dr. Denise Manahan-Vaughan, Johannes Mueller Institute for Physiology, Synaptic Plasticity Research Group, Humboldt University Medical Faculty (Charité), D-10115 Berlin, Germany. E-mail: denise.manahan-vaughan{at}charite.de.
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You are going to email the following Requirement of Translation But Not Transcription for the Maintenance of Long-Term Depression in the CA1 Region of Freely Moving Rats
Denise Manahan-Vaughan, Alexander Kulla, J. Uwe Frey
Journal of Neuroscience 15 November 2000, 20 (22) 8572-8576; DOI: 10.1523/JNEUROSCI.20-22-08572.2000
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text:
Samsung Galaxy S22 Ultra leaks in full glory: Galaxy Note-like design, S-Pen support, other details
Samsung is expected to launch the Galaxy S22 series in February, 2022.
Updated: December 31, 2021 10:57:07 pm
The phone is expected to be powered by Qualcomm Snapdragon 8 Gen 1. (Photo credit: @evleaks)
Samsung's next high-end Galaxy S phone, aka the Galaxy S22 Ultra, has leaked in full, courtesy Evan Blass (@evleaks). The serial tipster has shared what appears to be an official-looking render of the phone in question showing it off from every perceivable angle. The render confirms that the Galaxy S22 Ultra will come with a Galaxy Note-like design with a silo to house the bundled S-Pen stylus.
In tune with the expectations and circulations on the internet, the phone is expected to be more of what has already been speculated about. Initially, there was confusion as to how the camera would be arranged on the back side of the phone however that recently got sorted as the new look shows that each lens has been studded separately on the back of the phone.
Among other notable features unveiled in the recent leak of the device are inclusion of an S-Pen and close resemblance with the Note series device. Apart from the design there appear to be other similarities with the Galaxy Note 20 Ultra including the display which looks nearly identical with curved edges on the sides.
On the design front, the phone appears to fit into the classic Note series template with a boxy design. However, the camera module is speculated to have got a revamp in this phone. It has also been speculated that the phone has been designed to operate on the Qualcomm Snapdragon 8 Gen 1. However, there are a series of reports that have indicated that the phone in other markets such as India, UK and EU will be made to operate on the Exynos 2200 SoC.
I-T dept detects evasion worth crores after raids on 'foreign-controlled' mobile companies
Sustainability of business extremely important: CII Southern Region
Bank of Maharashtra Q3 net profit more than doubles to Rs 325 crore on higher NII growth
How this small manufacturer recovered Rs 3 crore pending dues from PSUs
5G services spectrum bands in India will not interfere with aircraft radar altimeters: ITU APT
Healthcare industry urges Government to leverage potenial of telemedicine, home care


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The Mamontov Gallery has just opened a show of works by Vladimir Serebrovsky (1937-2016), an artist known for his set decorations, easel painting, theater posters, and book graphics in the style of the Silver Age. He is perhaps best known for his work at the Moscow Art Theater, where he worked for 30 years.
The Mamontov Gallery specializes in Russian works of the 20th century, including many from the Silver Age. This period in Russian culture is usually dated to 1898, when Sergei Diaghilev and Alexander Benois produced the first edition of "The World of Art," a journal dedicated to ending the age of realism in art and ushering in more expressive and impressionistic art. Art of the Silver Age is hard to define, but is generally characterized by aestheticism, mysticism, decadence, and sensualism, often with romanticized elements of Eastern artistic traditions.
Although the Silver Age came to an end as movement in Russia by the 1930s, the spirit of the age has been kept alive by many artists, included Serebrovsky, who was influenced by such original Silver Age artists as Alexander Golovin, Ivan Bilibin, Mstislav Dobuzhinsky, and Benois. The gallery holds more than 70 paintings of the artist that were painted from 1970 to 2015.
Serebrovsky's mountain landscapes are different. They are lighter in palette and convey a mood of serenity, peace and harmony.
When Vladimir Serebrovsky moved back to Russia, he brought bright Asian colors to the Russian landscape. The artist found special charm in the beauty of Russian nature: chamomile and bay willow fields, ponds, forest paths, peonies and lilac bushes. You can see this in his paintings "Summer. Vladimir region" (2009); "Kuzminki" (2005); "Neskuchny Sad" (2004); and his series of the Andreyevsky Monastery (1995).


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What is sympathy give example?
Admin September 23, 2019 Advice
1 What is sympathy give example?
2 What are the types of sympathy?
3 What is the difference between empathy and sympathy give examples?
4 What are the 3 types of empathy?
5 What is a good sympathy message?
6 What flower symbolizes death of a loved one?
7 What is a person with no empathy called?
8 What is the best condolence message to a friend?
9 What to say condolences examples?
10 What are some words for sympathy?
Sympathy is defined as feeling sadness for other people or the act of expressing such feelings or identifying with a person or an idea. An example of sympathy is the way you feel for your friend when her husband dies. An example of sympathy is what you say to your friend when her husband dies.
What are the types of sympathy?
These include pity, compassion, fellow-feeling, commiseration and empathy.
What is the difference between empathy and sympathy give examples?
Empathy is a term we use for the ability to understand other people's feelings as if we were having them ourselves. Sympathy refers to the ability to take part in someone else's feelings, mostly by feeling sorrowful about their misfortune. …
How do you explain sympathy?
1 : sorrow or pity for another She felt sympathy for the poor lost puppy. 2 : readiness to favor or support He expressed sympathy for the protesters. 3 : a relationship between people or things in which whatever affects one similarly affects the other.
Why do we feel sympathy?
Sympathy acts in a way that provides a means of understanding another person's experience or situation, good or bad, with a focus on their individual well-being. It is often easier to make decisions based on emotional information, because all humans have general understanding of emotions.
What are the 3 types of empathy?
Empathy is an enormous concept. Renowned psychologists Daniel Goleman and Paul Ekman have identified three components of empathy: Cognitive, Emotional and Compassionate.
What is a good sympathy message?
"May you take comfort in loving memory and the friends and family that surround you." "May the pain you feel now be nothing compared to joy found within the memories of (name.)" "I can't express how much we loved and cherished (name). Our deepest condolences for your loss."
What flower symbolizes death of a loved one?
Chrysanthemums, also known as mums, carry several cultural meanings surrounding the death of a loved one.
What is empathy and examples?
When you feel an emotion along with someone, even if you aren't directly affected by whatever is causing their situation, that's empathy. Empathy Example 1: Have you ever felt sad with a friend just because he was sad? That's empathy!
What can I say instead of sorry for your loss?
You are in my thoughts and I am here for you.
Sending you my deepest condolences for the loss of your loved one.
I am so terribly sorry you're having to go through this.
You have the support and love from all those close to you at this time.
What is a person with no empathy called?
Psychopathy is a personality disorder characterized by a lack of empathy and remorse, shallow affect, glibness, manipulation and callousness.
What is the best condolence message to a friend?
Immediate Personal Condolences
I'm so sorry to hear of your loss.
I'm stunned by this news.
My heart aches to hear this news.
I love you and I'm here for you.
Please know that your friends love you and are here for you.
My deepest sympathies to you and your family.
God bless you and your family.
What to say condolences examples?
The definition of condolence is sympathy for someone who is grieving. An example of a condolence is a card you send when a friend's mother dies.
What to say when someone dies condolences?
When writing words of condolence on behalf of someone, you can say it like this, "I am very sorry to hear of your loss and my thoughts and prayers are with you and your family.". Be nice and tender, sensitive, sympathetic and caring. At some point, it may relieve the pain they feel and comfort the bereaved.
How to thank someone for expressions of sympathy?
Express thanks for the expression of sympathy. Sentences Thank you for the beautiful plant you sent while I was in the hospital. If you feel comfortable doing so, comment on how helpful the reader's expression was. Close with a final word of appreciation or anticipation of future relationship.
What are some words for sympathy?
When choosing the words of condolence for sympathy messages stick to comforting and soothing words. The following words are commonly included in sympathy messages: Sorry, Thoughts, Prayers, Miss, Genuine, Strength, Peace, Saddened, Condolences, Loss, Sincerely, Comforted, Memory.
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Command Alkon Inc. has acquired Rosemont, Ill.-based FiveCubits, a [software as a service] SaaS-based fleet management and mobile computing solutions provider for ready mixed and bulk materials producers, trucking and hauling companies, and contractors.
"In joining forces with Command Alkon, we are excited about the many integrated solutions we can offer to our joint customers to meet the evolving needs of the industry," adds FiveCubits Vice President and General Manager Rob Getz.
With offices in Illinois, Utah and California, FiveCubits will operate as a division of Command Alkon. Former CEO John Jazwiec will serve as an advisor to the Command Alkon board, bringing years of entrepreneurial and industry experience.


For better results (yep, you've guessed it…) use with Aussie Miracle Shine Conditioner and 3 Minute Miracle Shine Treatment.
Aussie Shampoo Miracle Shine special formula, with Australian Ginseng extract and Pearl powder, helps to revitalize tired, dull hair leaving it sensationally vibrant and shiny. Now you can just wash & glow.
Inspired by ancient Aussie beauty secrets, we used extracts of Australian Ginseng and Pearl powder in a secret shine formula. Pearls sparkle (duh!), and Ginseng is known for boosting energy (and being generally fabulous).
This miracle shine formula lets you and your hair shine sensationally, full of life and vibrancy. "Killibinbin!" you'll shout. (An ancient Aussie word for uber-shiny).


South Photography equipment is usually one of the biggest economies in the globe having presently already been placed 20th within the last census carried out for the calendar year 2009. But South Africa's plans for further enhancement in the economy are already well beneath way.
The brand-new industrial progress zones Southwest Africa plans to develop are a clear indicator that this government has its sight on pursuing a coverage to improve their world ranking. This really is great news to get both for buyers, (hungry for new business growth opportunities), and also for the local communities of which would benefit from the brand-new job opportunities the fact that these IDZs would offer.
For those of a person who are not really acquainted with term "IDZ", here is some sort of brief overview on precisely what a good IDZ is, precisely what the goals are at the rear of them, and how all these aspirations are going in order to be fulfilled.
The new manufacturing development zones S. africa will be planning to build, (some of which are previously under way), must each fulfill unique criteria like laid along by the Ministry of Industry. To start with the site must become effective at offering a proper financial benefit of some variety. This may be the web-site's location, close by for you to local, national transportation links for example. That should also have the potential to create a lot of new job opportunities. In addition it must end up being ready regarding taking advantage of any natural sources that already exist in the neighborhood, and it should get able to blend throughout with different local companies and processing processes, supporting and helping to expand territorial manufacturing, adding value to the local financial system together with creating new cohesions.
Some sort of great example of this of 1 from the new industrial enhancement areas South Africa presently has ongoing, is the IDZ at Saldanha Clean. One of the instant benefits that this certain IDZ gives you is the particular local, natural deep waters port. It's the perfect center for importing any parts and/or materials equally, whilst also offering a great unrivalled opportunity for volume conveying. There is a excellent freight railway connection via the Saldanha-Sishen railway, and with further developments planned to the existing slot facility, the transfer links will be earth class. Add to that, typically the expansion plans for you to turn the existing Saldanha Steel Plant directly into some sort of important world iron supplier, and you can see this enormous business potential that IDZs like Saldanha own to offer buyers.
In addition to the potential for an superb REVENUE (return on investments), the Industrial development zones S. africa plans to build may offer option traders further rewards by way of taxes concessions. Opportunity Zone Investments in just about all, the plans being supplied make very attractive reading, and the early symptoms can be that these new IDZs might be a huge advantage to the South African economy.
With the basic earth business economy solidly dress the route to be able to healing period, and the enormous potential of which South African-american IDZs present, the time for investment couldn't turn out to be more opportune. Prices continue to be relatively low, so simply by investing off plan nowadays, the returns in the near future can be really spectacular.


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Q: Почему параллельная часть кода работает медленнее последовательной? Пытаюсь разобраться с OpenMP,пробую распараллелить простой цикл for, но по времени параллельная версия работает хуже/одинаково с версией последовательной. Почему так? Понимаю, что есть расход ресурсов на распараллеливание, но вроде должно при таком объеме данных дать хоть какой-то прирост. Компилирую с ключом -fopenmp (g++ -fopenmp filename.cpp). Был бы также крайне благодарен, если бы кто-то посоветовал хороший гайд по OpenMP.
#include <stdio.h>
#include <stdlib.h>
#include <omp.h>
#include <iostream>
#include <chrono>
#define N 100000000
int main(void)
{
    int* a = new int[N]{};
    int* b = new int[N]{};

    auto begin = std::chrono::steady_clock::now();
    #pragma omp parallel
    {
        for (int i =0;i<N;i++)
        {
            a[i] = a[i]+1;
        }
    }
    auto end = std::chrono::steady_clock::now();
    auto elapsed_ms = std::chrono::duration_cast<std::chrono::milliseconds>(end - begin);
    std::cout << "The time: " << elapsed_ms.count() << " ms\n";

begin = std::chrono::steady_clock::now();
        for (int i =0;i<N;i++)
        {
            b[i] = b[i]+1;
        }
end = std::chrono::steady_clock::now();
elapsed_ms = std::chrono::duration_cast<std::chrono::milliseconds>(end - begin);
    std::cout << "The time: " << elapsed_ms.count() << " ms\n";
    return 0;
}

A: В Вашем варианте каждая итерация цикла будет запускаться как бы в отдельным подходом. Сама итерация мелкая, поэтому накладные расходы коллосальные. Что делать? Самому сделать вложенный цикл, что бы обрабатывать блоками или использовать #pragma omp for, которая сделает это автоматом. Ваш случай описан здесь https://habr.com/ru/company/intel/blog/85273/

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text:
I love science, technology, new ideas, and new ventures. For the last 20 years, I have helped early stage start-up companies in Silicon Valley build products customers rave about. My career track record includes over $1.1B in successful acquisitions and IPOs. In the last 5 years, I led 2 startups to successful acquisitions for more than $100M. I am passionate about user experience, software engineering, and lean methodologies. My technology expertise ranges from hardware to software, to large-scale and high-availability internet applications, to infrastructure hosting and service providers. Recently, my technical focus has been on web application development with Ruby on Rails and Java, developing products and solutions for cloud systems management.
Currently, I am the founder and Principal of Rave Media, and the co-founder of Semantiq AI. Formerly, I was a technology strategist in the CTO Office of Dell, where I was Executive Director and CTO of Dell Cloud Marketplace. Previously, I was the CTO of Gale Technologies, acquired by Dell in November of 2012. Before joining Gale, I was the CTO and Founder of Virtiv, acquired by Gale in January of 2011.
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