text:
Single test can predict progression of untreated precancerous cervical disease
Reviewed by Kate Anderton, B.Sc. (Editor)Jul 31 2019
A single test for women has been shown to aid in predicting which cases of precancerous cervical disease will become more serious, helping with decisions on whether or not surgery is needed, according to a study led by Queen Mary University of London.
For thousands of young women who receive a diagnosis of cervical dysplasia, the decision on how to proceed can be uncertain, confusing, and difficult. In the majority of cases, moderate cervical dysplasia (also called cervical intraepithelial neoplasia 2, CIN2) will resolve itself, but some of these women will go on to develop cervical cancer. Women with moderate dysplasia may face a choice between undergoing prompt treatment, or short-term surveillance.
In the UK most women with moderate dysplasia are advised to undergo surgery without delay, but this has a risk for the outcome of future pregnancies, including miscarriages and premature deliveries. Until now there has been no test to show whether or not their cervical disease will progress.
The study, published in the journal of Clinical Infectious Diseases, looked at different options for these young women and found a test that was able to identify which women with moderate dysplasia are actually at high risk of their disease going on to severe dysplasia (CIN3).
The clinical study involved 149 women in Finland aged around 26 with identified CIN2. It showed that the S5 DNA methylation test is the best predictor of whether moderate cervical disease will progress to CIN3. The single test performed much better than the methods currently used to monitor existing disease.
The study shows that most women with moderate dysplasia can be followed without treatment until their disease resolves. This finding has important global implications for the treatment of millions of young women with cervical disease.
The researchers hope that this discovery will lead to a major change in medical practice, with more active surveillance and fewer surgical interventions. This could also bring cost savings, both for the treatment itself, and the possible costs of caring for premature infants.
Author and Emeritus Professor Attila Lorincz from Queen Mary University of London explained:
It is scary for young women with a potentially serious dysplasia to be told that they may get cancer if they do not undergo surgery. Unfortunately, surgery can lead to a painful and distressing recovery period. In future pregnancies there are substantially higher rates of miscarriage, infection, or premature delivery for mothers as well as many risks for the foetus. Our study shows that most women with moderate dysplasia can be followed without treatment until their disease regresses. This gives the women a better chance for easy and safe pregnancies in the future."
The DNA methylation test is currently under development and more studies in different countries will need to take place as the test moves into routine use. If successful, the researchers say that the test is expected to be available next year in Asia. A CE-marked test, indicating conformity with health and safety standards for sale within Europe, could be available in the UK in the next 2 to 3 years at which point it will be eligible for consideration by the NHS.
Louvanto, K. et al. (2019) Methylation in predicting progression of untreated high-grade cervical intraepithelial neoplasia. Clinical Infectious Diseases. doi.org/10.1093/cid/ciz677.
Posted in: Medical Science News | Medical Research News | Women's Health News
Tags: Cancer, Cervical Cancer, Cervical Dysplasia, Cervical Intraepithelial Neoplasia, Dentistry, DNA, DNA Methylation, Dysplasia, Education, Hospital, Infectious Diseases, Medical School, Medicine, Miscarriage, neoplasia, Research, Surgery
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Search Results for "RED AND WHITE"
In Red List white spring daffodil meadow in a bright sunshine. Spring landscape. No people around. Outside shooting, sunlight on the background. Natural, spring atmosphere.
Bread basket with red and white checkered napkin filled with fresh brown pretzels. Top view. Placed on stone table.
Happy young woman making online Christmas purchases using her laptop and credit card as she relaxes in a Santa hat in a festive red and white living room.
Tasty red tomatoes white onions and juicy beefsteak fresh rosemary lying on the kitchen board closeup. The camera moves from left to right.
Tired young woman napping in front of an Xmas tree with a large heap of colorful red and white Christmas gifts on a comfortable sofa in her living room.
Tasty red tomatoes white onions and juicy beefsteak fresh rosemary lying on the kitchen board closeup. The camera moves from right to left.


Me again! This is my part two post, of 'how to take a bright and airy photo'. I promised in my previous post that I'll explain a bit on how I use my manual settings on my Canon EOS 70D. Keep in mind, I am not a professional photographer by any means. I've just watched a few youtube videos and played with the settings. A lot of trial and error.. and a lot of photos! I'll try to keep this very basic!
I like to use the manual setting simply because this lets me bring in lots of extra light, which give you that "bright and airy" look your photos.
I always start with the ISO setting= how sensitive the camera is to light. If it's really bright out I'll leave the ISO nice and low 100 to 400, when I'm in a darker room I'll bring up the ISO accordingly. If you are setting up your baby infant of a window as shown in the #babymoments app, you'll want your ISO to be on the lower end.
Then I liked to think about the Aperture: How much light enters though the lens, which is measured in 'f-stops'.
The lower the 'f-stop', the more light coming through the lens= bright photos. I typically like to have my f-stop low 1.2, 1.4,- 4.0. (Note: A great lens to start is the 50mm or 40mm-that I used in the above photos.) Lower f-stops not only allow for more light to come in, but also gives you that blurry landscape ("broken") behind your subject. This is called depth of field (DOF)- the amount of your shot that will be in focus. Large DOF means that most of your image will be in focus (high f-stop ex: f/22). Small or shallow depth of field means that only a part of your image will be in focus. For example your sweet baby, with all the pillows on your bed blurred out in the background (low f-stop 1.4-4.5). Again, for a blurred background lower your aperture down, ex: f/1.4.
Shutter speed is the length of time that the shutter is open, to expose light into the camera. This is why I like to play around with the SS in terms of controlling the light.
When you look on your camera screen, or the view finder you'll see a scale of numbers will 0 being in the centre. I like to have my exposure set in-between 0…+1….+2, a bit over exposed. Over exposed photos are very light, whereas underexposed are dark- below the "0". Some say to keep the exposure exactly on "0", however as I've mentioned I like them a bit more over exposed.
All that being said, you need light! Shoot your photos with a space that is well lit, and by that I mean NATURAL LIGHT. I can even capture some great shots with my iPhone by simply having natural light!
Okay now all that work to still fix up a photo with a little bit of editing! I do edit my photos either on my computer or on my phone. So not take those amazing photos you just captured an add a little extra to them. Using your smart phone can be really quick and easy, send yourself the photo you jus shot on your SLR and upload it onto your phone. I like to use: Afterlight, Snapseed, PicTapGo which can all be found in your app store.
1. Bring up the brightness/ exposure to brighten your photo a bit more.
2. Bring down the shadows a bit to bring out the colors, incase they washed out a bit with the brightening.
3. Bring down the temperature a tad if you are still finding your photo a bit yellow.
4. Sharpen the photo to make it extra crisp and sharp.
The demo above shows the before and after using the Afterlight app on your smart phone. I love the expression on Liam's face in this image, but as you can see it is not the best quality in terms of lighting. This photo is a more underexposed then most of the photos I edit. But I want to show you the difference of how easy it is to transform a not so great photo, or an okay photo and make it look nice and "bright and airy".
And that's it! Have fun with your camera and settings! And if some of your photos didn't quite turn out the way they you wanted them too, a little editing never hurt!


text:
Storå är en 86 kilometer lång å på västra Jylland,  km väster om Köpenhamn. Den rinner upp vid Gludsted Plantage i Ikast-Brande kommun, rinner genom Hernings kommun och mynnar i Felsted Kog, den sydöstra delen av Nissum Fjord i Holstebro kommun. Strax öster om Holstebro är ån uppdämd och bildar den 3 km långa Vandkraftsøen. Dess större tillflöden är Herningsholm Å, Sunds Nørreå, Røjen Bæk, Råsted Lilleå, Tvis Å, Vegen Å, Grydeå och Idom Å.

Källor
 http://www.denstoredanske.dk/Danmarks_geografi_og_historie/Danmarks_geografi/Jylland/Stor%C3%A5

Noter

Vattendrag i Region Mittjylland
Nordsjöns avrinningsområde

redpajama_set_name: RedPajamaWikipedia


Home » Alphabet Soup Mama in Toledo Parent News » Job Title: WRITER!
This entry was posted in Alphabet Soup Mama in Toledo Parent News, Momness, Toledo Parent News and tagged column, columnist, journalist, Toledo Parent News, writer. Bookmark the permalink.


6 years ago on the night before our wedding we went to see Shakes in the park and we've continued the tradition every year (it's Midsummer's Eve too!). The weather was perfect and the verse was verse-y. We went twice this year for the Scottish Play.
Wish you could have been there! Maybe next year!


text:
unless Rails.env.production? # rubocop:disable Naming/FileName
  require 'haml_lint/haml_visitor'
  require 'haml_lint/linter'
  require 'haml_lint/linter_registry'

  module HamlLint
    class Linter::InlineJavaScript < Linter
      include LinterRegistry

      def visit_filter(node)
        return unless node.filter_type == 'javascript'

        record_lint(node, 'Inline JavaScript is discouraged (https://docs.gitlab.com/ee/development/gotchas.html#do-not-use-inline-javascript-in-views)')
      end

      def visit_tag(node)
        return unless node.tag_name == 'script'

        record_lint(node, 'Inline JavaScript is discouraged (https://docs.gitlab.com/ee/development/gotchas.html#do-not-use-inline-javascript-in-views)')
      end
    end
  end
end

redpajama_set_name: RedPajamaGithub


text:
Lessons From Ronald Knox
by Sohrab Ahmari 7 . 30 . 20
To read the biography of Monsignor Ronald Knox is to risk sinking into despair. The great English Catholic convert, biblical translator, and writer lived such an outstanding life that one can't but feel the utter inadequacy of one's own next to its record.
Knox (1888-1957) was composing decent Latin poetry by age ten. He attended Eton and Oxford, where he was counted among the most promising young scholars of his generation. His gift for friendship made him the toast of many circles. He staked out strong liturgical, ecclesiastic, and theological positions without making enemies in the process—though he certainly had critics, not least in his own family.
As a Church of England clergyman, he was seen as the great hope of Anglo-Catholicism. After he "went pope" (in the expression of his time), his influence as a Catholic convert rivaled that of Newman in the previous century. He was a writer of strikingly warm and precise prose, qualities rarely found together. His books sold out. He was a spiritual confidant of Chesterton, a creative and beloved teacher, a hot-in-demand homilist, an eminently good man.
His only shortcoming, it seems, was his unfortunate physical appearance and the strange vanity associated with it. As Evelyn Waugh tells us in his gorgeous life of Knox, when the would-be churchman first arrived at Oxford he was "a frail, slightly drooping figure with a prominent nose, a heavy underlip which his pipe accentuated, unobtrusive chin, large eyes." He was eighteen years old. Yet despite these features, Knox harbored a "whimsical hope that he might be thought of as good-looking."
As I say, it's hard to read the biography without envy tinging one's admiration. Hard for me anyways, knowing, at age thirty-five, that I won't achieve the ten-year-old Knox's facility with ancient Italian, no matter how much I apply myself to Mr. Gwynne's instruction books. Like Knox, I've staked out strong positions, but have made oodles of enemies in the process. And I fall far short of the man's well-attested goodness and holiness.
And yet, as I spent the summer days with Waugh's biography, I felt constantly as if Knox was inviting me to lift myself up to the level of his natural virtues—and as if he was somehow dispensing his supernatural gifts from Waugh's pages into my mind and soul. Such a man was Knox; such a biographer, Waugh.
The details of Ronald Arbuthnott Knox's life are familiar to fans of English-Catholic lore. He was born in Leicestershire to Anglican evangelical royalty. His paternal grandfather, the Rev. George Knox, was a missionary of austere Calvinist practice; his father, Edmund Knox, the Anglican bishop of Manchester, was a scourge of Tractarians and all things Romish and incensed. His maternal grandfather, on the other hand, was much more the small-c catholic: a mystic, "a Protestant Charles de Foucauld," as Waugh puts it. He died emaciated, tilling the missionary field in Oman.
One of the most delightful aspects of Ronald Knox the adult convert was how he consciously upheld his English and Anglican patrimony even as he discovered the fullness of catholicity in the Roman church. Thus, at the height of the Blitz, he urged the refugee Catholic schoolgirls entrusted to his spiritual care in the countryside to resist any nationalism that might pinch their loyalty to the universal church and put them at odds with the Communion of the Saints. At the same time, as he confided to a friend:
I'm not going to decide whether the average Catholic Mexican is what you call a 'better man' than the average Protestant Englishman. I do not know—I know which I would rather go for a walking tour with, but that is not the same thing. I prefer Englishmen to the natives of any other country in the world, but that is not going to do them much good, poor dears, at the Day of Judgment.
Knox traced his conversion to his teenaged reading of Robert Hugh Benson's The Light Invisible, written while the author himself was still an Anglican—a book packed, as Waugh says, with "aesthetic and emotional appeal of a kind most Catholics would condemn as second-rate" (Waugh, it seems, never had a kind thing to say about one of Pope Francis's favorite authors!). Yet The Light Invisible implanted in the young Knox a love for the Virgin and an awareness of the priesthood "as a peculiar state" with a primarily sacramental role, as opposed to the primarily exhortatory role of his own evangelical father.
The road from that early brush with the sacramental priesthood to being received into the Catholic Church was straightforward but by no means easy; Knox was one of those Anglicans whose crossing of the Tiber appears inevitable to all but themselves until the deed is done.
Along the way, he dabbled in Christian socialism and described himself as a "Tory socialist." But he was "no economist," as Waugh gently puts it, and more than that, Knox wasn't a party man or a full-ticket intellectual (the kind whose views line up just perfectly). He could make lighthearted fun of fellow Oxford Anglo-Catholics who took things a little too seriously, especially given their reluctance to surrender their, er, privilege in the bargain of Christian socialism. Knox ribbed one such friend with a Gilbert-style send-up:
A fight-the-police young man,
A don't-go-to-war young man;
An early-Tractarian
Take-in-the-Clarion
Dine-at-the-Ritz young man
Who wouldn't have been charmed by these lines? Or who could have held them against Knox?
But if he converted to Catholicism without hurting many feelings—except his father's, that is—it wasn't because "going pope" had lost its transgressive dimension. No, it was because he was already mostly friendless by the time he was received. Many of his dearest Anglo-Catholic bosom buddies had died in the trenches of World War I; others had preceded him across the Tiber; and still others had gone pope—and then died fighting.
It is the war-wounded Knox that arouses the most tender sympathy and offers us a model amid our own moment of national crisis. How did Knox handle losing so many friends?
With prayer, is the short answer. Knox didn't see coming, Waugh notes, "the monstrous physical catastrophe that impended, but while his countrymen were singing and waving flags [in the early days of the war], he stood back aghast at the gross dislocation in the moral order, which kept him on his knees, alone, six hours a day for the last three weeks of the month."
By my calculation, that's 126 hours spent on the prie-dieu. Was every minute filled with ecstatic prayer? No. As he wrote to a friend seeking advice on prayer, "it is only by [God's] mercy, I think, that religious practices ever become easy for us. We must expect always to have to set our teeth." In another context: "To be dry in Lent when our Lord fasted, to be feeling irreligious on Good Friday, when our Lord suffered dereliction—all this is quite correct and liturgical." These words, Waugh speculates, "suggest that Ronald's prayer throughout most of his life, was very often dry and laborious."
And yet he spent 126 hours in a month kneeling for the English boys in the trenches, praying that God might use English arms as an instrument of his peace and justice. An observer who had seen him on his knees before the Blessed Sacrament wrote: "I have seen people in love with God"—namely, Knox. And what's more admirably English than to struggle at praying but to keep at it for 126 hours in a month for love of God and one's friends?
A reassuring thought for lesser men: Monsignor Knox wasn't good at everything!
Sohrab Ahmari is the op-ed editor of the New York Post and author of The Unbroken Thread: Discovering the Wisdom of Tradition in an Age of Chaos, which will be published next spring.
Photo by Hugh Llewelyn via Creative Commons. Image cropped.
More on: Religion, British History, Catholicism, Anglicanism, Evelyn Waugh
Articles by Sohrab Ahmari

redpajama_set_name: RedPajamaCommonCrawl


The Civic Analytics Graduate Student Fellowship invites up to four current NYU MS or PhD students for an intensive four-month applied urban data science fellowship program at NYU's Marron Institute. Students are welcome from all disciplines and programs across NYU, and we seek a diversity of disciplinary training, backgrounds, and perspectives. The Fellowship projects are data-focused, so candidates with expertise in data science, machine learning, statistical modeling, spatial analysis and visualization, network analysis, etc. are encouraged to apply. The Fellows, led by Prof. Constantine E. Kontokosta as part of the Civic Analytics Program, will work together, alongside a team of full-time researchers and PhD students in the Urban Intelligence Lab, and directly with city agencies on data analytics projects to address critical operational and policy challenges and drive positive social impact.
Fellows will work with city agencies on operational and policy challenges using data analytics to provide new insight and knowledge. Fellows will: learn about key performance indicators and agency-specific measures of success, scope the data project and determine how data-driven analysis can result in better outcomes, assemble and integrate the data necessary for analysis, deliver outputs that help to achieve the greatest social impact while accounting for resource and institutional constraints. Fellows will work together in small teams on moving projects from alpha to beta/live.
Work on one (and up to three) analytics research projects with city agencies and NGOs, including the Fire Department of New York, the Department of Sanitation, the Mayor's Office of Sustainability, the Trust for Governor's Island, NYC311, and the Mayor's Office of Data Analytics.
Produce data tools, visualization, models, code, and recommendations to city agencies designed to directly impact the challenge identified for a particular project.
Contribute to conference and journal publications and case studies.
Application materials should be sent to bartosz.bonczak@nyu.edu no later than February 1st, 2019.
Fellows will begin mid-February and complete their work by June 15th, 2019. Compensation is $18/hour for up to 20 hours per week. Fellows will be assigned workspace (as available) at the NYU Marron Institute for their Fellowship-related activities.


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