Even bacteria have a kind of "immune system" they use to defend themselves against unwanted intruders – in their case, viruses. Scientists at the Helmholtz Center for Infection Research (HZI) in Braunschweig, Germany, were now able to show that this defense system is much more diverse than previously thought and that it comes in multiple versions. Their goal is to use the various newly discovered versions of the CRISPR-Cas gene for the targeted manipulation of genetic information, particularly for medical purposes.
The human immune system's main function is to protect us against invading bacteria, viruses, and other pathogens. To perform its job, the system has evolved into a highly complex ensemble of cells, messengers, and antibody molecules that is capable of recognizing different pathogens, defending us against them, and storing information about them.
© HZI / RohdeStreptococcus pyogenes, shown here while entering a cell, is one of the germs whose CRISPR-Cas system the scientists from Braunschweig have studied.
Even the bacteria themselves are threatened by pathogens: Certain viruses, the bacteriophages (literally, "bacteria eaters"), have become specialized to invade bacterial cells and proliferate inside of them. In order to get rid of these unwanted guests, many species of bacteria make use of an arsenal of molecules that works according to similar principles as an immune system does.
The Cas enzyme recognizes DNA molecules that contain non-self genetic information, e.g. from bacteriophages, and cleaves them at specific sites. In order to recognize these molecules, a molecular copy of specific, characteristic sections of the foreign DNA is required. This copy, a kind of "molecular profile" of bacteriophage DNA and other foreign genetic material, exists as RNA, an important cellular building block, which is used, among other things, as a temporary storage site of genetic information.
The template for this profile is stored in the bacterium's own genes, specifically in those regions scientists call CRISPR (which stands for "clustered regularly interspaced small palindromic repeats" or, more simply put, the "regular arrangement of small, symmetric repeats" in the sequence of the DNA building blocks). Together, the enzyme and the profile RNA constitute the CRISPR-Cas system.


text:
package.path = "../src/?.lua;" .. package.path
local sandbox = require "sandbox"

local code = [[
stuff = 42

function get_secret()
    return secret
end

function get_globals()
    local res = {}
    for k, v in pairs(_G) do
        res[#res + 1] = k .. "=" .. type(v)
    end
    table.sort(res)
    return table.concat(res, " ")
end

function read_file(filename)
    local file = assert(io.open(filename))
    local data = file:read "*a"
    file:close()
    return data
end

function hack(fn)
    local g
    if getfenv then
        g = getfenv(fn)
    elseif debug and debug.getupvalue then
        local i, n = 1
        repeat
            n, g = debug.getupvalue(fn, i)
            i = i + 1
        until n == "_ENV" or n == nil
    end
    return g and g.secret or nil
end

return stuff
]]

secret = "asdf1234"

local env, ret = sandbox.eval(code)
assert(env, ret)

assert(ret == env.stuff, "return value")
assert(env.get_secret() ~= secret, "get_secret")
assert(env.get_globals() == "get_globals=function get_secret=function hack=function read_file=function stuff=number", "get_globals")
assert(pcall(env.read_file, "./test.lua") == false, "read_file")
assert(env.hack(function() return asdf end) ~= secret, "hack")

print "tests OK"

redpajama_set_name: RedPajamaGithub


Considering its award-winning creative team include American playwright Terrence McNally (Kiss Of The Spiderwoman, The Visit) and dynamic musical duo Lynn Ahrens and Stephen Flaherty (Once On This Island, Anastasia), it came as no surprise when ebullient turn-of-the-century musical Ragtime cleaned up at the 1998 Tony Awards, winning four of the accolades including Best Book and Best Score. Beyond Broadway, the historic rhythms of the production's march, gospel and ragtime-infused song and dance numbers have made it a popular choice for revivals across the US.
Over two decades since its first showing in the City of Angels, Ragtime returns to the Pasadena Playhouse for a strictly limited run this winter. Its thrilling story is set in the melting pot of New York City in the early 20th century, a time of great upheaval and change. Told through the eyes of three very different classes of people, it offers a snapshot of the era's musical evolution and the growing connection between the city's residents.
There's Sarah, a beautiful young woman who lives in Harlem and is at the heart of the neighbourhood's new form of syncopated jazz, pioneered by the likes of Coalhouse Walker Jr. Worlds collide as her story interweaves with that of an upper-class white family from New Rochelle and a community of immigrants of the Lower East Side - such connections are further solidified by famous faces and names like Harry Houdini, Evelyn Nesbit and Booker T. Washington.
Seen Ragtime? Loved it? Hated it?
Sound good to you? Share this page on social media and let your friends know about Ragtime at Pasadena Playhouse.


text:
Q: Xcode error in linker i am new iPhone developer. i got this error.

Ld
  /Users/c4ntechnology/Library/Developer/Xcode/DerivedData/iPatientCare-azwpvvrjjoaoygfcfqiicwkyssya/Build/Products/Debug-iphonesimulator/iPatientCare.app/iPatientCare
  normal i386
      cd /Users/c4ntechnology/Desktop/iPatientCare
      setenv MACOSX_DEPLOYMENT_TARGET 10.6
      setenv PATH "/Applications/Xcode.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/usr/bin:/Applications/Xcode.app/Contents/Developer/usr/bin:/usr/bin:/bin:/usr/sbin:/sbin"
      /Applications/Xcode.app/Contents/Developer/Toolchains/XcodeDefault.xctoolchain/usr/bin/clang
  -arch i386 -isysroot /Applications/Xcode.app/Contents/Developer/Platforms/iPhoneSimulator.platform/Developer/SDKs/iPhoneSimulator5.1.sdk
  -L/Users/c4ntechnology/Library/Developer/Xcode/DerivedData/iPatientCare-azwpvvrjjoaoygfcfqiicwkyssya/Build/Products/Debug-iphonesimulator
  -F/Users/c4ntechnology/Library/Developer/Xcode/DerivedData/iPatientCare-azwpvvrjjoaoygfcfqiicwkyssya/Build/Products/Debug-iphonesimulator
  -filelist /Users/c4ntechnology/Library/Developer/Xcode/DerivedData/iPatientCare-azwpvvrjjoaoygfcfqiicwkyssya/Build/Intermediates/iPatientCare.build/Debug-iphonesimulator/iPatientCare.build/Objects-normal/i386/iPatientCare.LinkFileList
  -mmacosx-version-min=10.6 -Xlinker -objc_abi_version -Xlinker 2 -fobjc-arc -fobjc-link-runtime -Xlinker -no_implicit_dylibs -D__IPHONE_OS_VERSION_MIN_REQUIRED=50100 -lsqlite3 -framework UIKit -framework AVFoundation -framework CoreGraphics -o /Users/c4ntechnology/Library/Developer/Xcode/DerivedData/iPatientCare-azwpvvrjjoaoygfcfqiicwkyssya/Build/Products/Debug-iphonesimulator/iPatientCare.app/iPatientCare
Undefined symbols for architecture i386:
  "_OBJC_CLASS_$_ViewController", referenced from:
        objc-class-ref in AppDelegate.o ld: symbol(s) not found for architecture i386 clang: error: linker command failed with exit code 1
  (use -v to see invocation)
"_OBJC_CLASS_$_ViewController", referenced from:
clang: error: linker command failed with exit code 1 (use -v to see
  invocation)

please help me

A: This compiler error means your AppDelegate class is referencing the ViewController class in your project, but the ViewController isn't currently set up to be compiled and included in the final product.
To make sure the ViewController class is included in the final product, select the blue Xcode project icon in the upper left column like shown in the image below:

Then select your target in the next column over, then select the Build Phases tab, and make sure ViewController.m is included in the list along with AppDelegate.m and others like shown. To add it if it's not currently there, you can drag the icon of it in the very leftmost column and drop it into the Compile Sources table view, or click the + button at the bottom of that table view.

A: The UIKit class is called UIViewController, you are most likely missing the "UI" part. You have to import <UIKit/UIKit.h> to use this class, but it is most likely already included in your MyApp-Prefix.pch. If ViewController is a class of your own, you must:
#import "ViewController.h"

redpajama_set_name: RedPajamaStackExchange


text:
Shares of KOP Up 25.7% Since Uptrend Call on Shares
SmarTrend identified an Uptrend for Koppers Holdings (NYSE:KOP) on October 21st, 2019 at $30.44. In approximately 1 month, Koppers Holdings has returned 25.70% as of today's recent price of $38.26.
Over the past year, Koppers Holdings has traded in a range of $15.00 to $44.28 and is now at $38.26, 155% above that low. Over the past week, the 200-day moving average (MA) has gone up 0.8% while the 50-day MA has advanced 1.6%.
Koppers Holdings, Inc. manufactures carbon compounds and wood treatments. The Company distills coal tar into carbon pitch, creosote, and phthalic anhydride, which are used to produce aluminum, plasticizers, and specialty chemicals. Koppers also manufactures railroad ties.
SmarTrend will continue to scan these moving averages and a number of other proprietary indicators for any shifts in the trajectory of Koppers Holdings shares.
Log in and add Koppers Holdings (KOP) to your watchlist today so you can receive a real-time alert when the shares are about to change trend.
Keywords: spotlights koppers holdings
Ticker(s): KOP

redpajama_set_name: RedPajamaCommonCrawl


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Mexico City is experiencing the worst floods in two decades after 48 straight hours of rain.The government has declared a state of emergency, and the sheer volume of water has completely overwhelmed the city's underground drainage system. Thousands have been effected.
One wonders where Mexican gangsters get such colorful nicknames: Los 20, El Borrado, El ChupA?n. Then again, one is probably safer not knowing.


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California Punitive Damages: Punitive damages for IP suits in the EU?
Punitive damages for IP suits in the EU?
European courts are generally not fans of American-style punitive damages, as we have noted. But the World Intellectual Property Review has an interesting article about a recent decision from the Court of Justice of the European Union: "EU law doesn't prevent punitive damages in IP suits, says CJEU." According to the article, the Polish Supreme Court took the view that punitive damages are not allowed for copyright infringement cases in the EU, but it asked the CJEU for a definite ruling on the issue. The CJEU took up the issue and held that EU member states are permitted to award punitive damages in copyright infringement cases if they so choose.


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text:
Eco Friendly & Sustainable Living
& Info
& Solar
Eco Web
amphitheater, Tag
A forgotten railway takes on new life as a new cultural destination in France Tue, 10 Dec 19, 5:30am
In the Alsace region of eastern France, Oslo-based architectural firm Reiulf Ramstad Arkitekter and French design studio Parenthèse Paysage have teamed up to transform the historic, 11-kilometer-long Rosheim-St Nabor railway...
Lemay injects new life into Montreals Expo 67 site Fri, 8 Nov 19, 2:30am
Canadian multidisciplinary design firm Lemay recently revitalized a core area on the site of Expo 67, the 1967 International and Universal Exposition that was held in Montreal and is considered the most successful World's...
Zaha Hadid Architects undulating riverside promenade doubles as a flood barrier in Hamburg Fri, 23 Aug 19, 4:30am
Zaha Hadid Architects has raised both the cultural cachet and the storm surge barriers in the German city of Hamburg with their recently completed upgrade to the Elbe River promenade and flood barrier at Niederhafen...
MADs ethereal Yiwu Grand Theater will float on Zhejiang waters Sat, 6 Jul 19, 3:30am
Beijing-based architectural firm MAD Architects has won a competition for Zhejiang's Yiwu Grand Theater with a proposal that's stunning, sculptural and site-specific...
Sydneys vibrant Green Square Library and Plaza collects and reuses rainwater Fri, 8 Feb 19, 6:30am
Former marshland in Sydney has been transformed into the new Green Square Library and Plaza, a striking project that's not only revitalizing one of the city's oldest industrial areas but is also a shining beacon for sustainability...
Solar-powered glass cafe overlooks a green lung in Jerusalem Thu, 10 Jan 19, 2:30am
Sacher Park, the largest public park in the center of Jerusalem, Israel, has recently gained a new cafe that embraces its green surroundings with walls of glass and an environmentally sensitive design...
Calgary Central Library is wrapped in a striking, snowflake-like facade Thu, 8 Nov 18, 6:30am
Calgary's new Central Library has just opened its doors to the public — and it's a thing of elegant, energy-efficient beauty. International architecture firm Snøhetta teamed up with North America-based multidisciplinary...
Frank Gehry tops Facebook HQ expansion with a 3.6-acre rooftop park Thu, 20 Sep 18, 4:30am
Facebook recently unveiled a peek inside MPK 21, its newest campus building designed by Frank Gehry and built in less than 18 months. Created as an extension to its headquarters in Menlo Park, California, this striking addition...
Dramatic fountain and plaza define Foster + Partners newest Apple Store in Milan Tue, 31 Jul 18, 4:45am
Foster + Partners has unveiled images of Milan's newest Apple Store—and it's just as strikingly gorgeous as we expected. Building off of Apple's "Town Square" retail store concept and the city's legacy of impressive...
The LEED Gold-seeking Edible Academy teaches urban farming in NYC Sat, 30 Jun 18, 1:00am
New York-based architecture firm Cooper Robertson recently completed the latest addition to the New York Botanical Garden in the Bronx — the Edible Academy, a new LEED Gold-seeking facility that will teach the greater...
This breezy bamboo amphitheater pops up in just 25 days Thu, 22 Feb 18, 8:57pm
A beautiful bamboo amphitheater has risen in the lush tropics of Rio de Janeiro. Brazilian studio Bambutec Design crafted the 2,150-square-foot structure with the help of computer modeling in addition to old-fashioned model...
Proposed Swedish bridge offers stellar river views with amphitheater-like seating Wed, 14 Feb 18, 9:14pm
Erik Andersson Architects has proposed a new type of bridge for Kalix, Sweden that does more than just connect riverbanks—it also doubles as coveted public space...
Tree-topped bridge to double as public space for a historic Chinese town Thu, 8 Feb 18, 9:29pm
MVRDV has won a competition for Dawn Bridge, a new multi-use bridge near Shanghai that will give locals and visitors the chance to experience a historic Chinese water town in a whole new way...
Y-shaped German hostel looks at sustainability from all angles Mon, 29 Jan 18, 9:57pm
A newly opened youth hostel in Bayreuth, Germany offers much more than just a clean bed and shower—the 180-bed Y-shaped building embraces community, holistic sustainability, and a passion for sports...
OMAs MPavilion 2017 with a floating roof opens today in Melbourne Mon, 2 Oct 17, 7:30pm
Melbourne is heating up for the summer with a new OMA-designed amphitheater. OMA founder Rem Koolhaas and colleague Daniel Gianotten just completed MPavilion 2017, a temporary pavilion that opened today in Melbourne's Queen...
Popular Related Tags: amphitheater, gallery, carousel showcase, pavilion, landscape architecture, public space, green building, plaza, adaptive reuse, temporary pavilion
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text:
Synchronicity in Whole Plant Medicine - Cannabis Digest
Synchronicity in Whole Plant Medicine
October 16, 2011 May 3, 2014 Owen SmithComment(0)
By Owen Smith
Abbreviations: D9-THC, D9-tetrahydrocannabinol; D8-THC, D8-tetrahydrocannabinol; CBN, cannabinol; CBD, cannabidiol; D9-THCV, D9-tetrahydrocannabivarin; CBC, cannabichromene; CBG, cannabigerol; D9-THCA, D9-tetrahydrocannabinolic acid; CBDA, cannabidiolic acid; TRPV1, transient receptor potential vanilloid type 1; PPARg, peroxisome proliferator-activated receptor g; ROS, reactive oxygen species; 5-HT1A, 5-hydroxytryptamine receptor subtype 1A; FAAH, fatty acid amide hydrolase.(+), direct or indirect activation; ", increase; #, decrease.
In the last article I discussed how the flowers, stalk, and leaves of the cannabis plant can be used to create a range of edible medical products that offer stimulation for the daytime, and sedation for at night. I began to explore the role of cannabidiol (CBD) in the treatment of many serious medical conditions and in relation to tetrahydrocannabinol (THC) in whole plant cannabis. Also, the synthetic THC pills were discussed, as presently pharmaceutical companies develop synthetic CBD compounds for a wide range of conditions (see Figure 1). As patients in pain lose patience with prohibition, scientists in labs are opening the Pandora's Box of whole plant cannabis, confirming its important role in understanding human health.
To better understand the complexities of cannabis and our health we need to learn about our endocannabinoid system (ECS). "Endocannabinoids are lipid compounds produced in our bodies by burning and making fats."1 These compounds are like keys that fit into neurotransmitter receptor sites, widely distributed throughout our bodies, like specific locks. When a key (ex. 2-AG) binds with a lock (ex. CB1) the site is activated. These ECS receptor sites are activated by synthetic and plant derived phytocannabinoids, as well as by the internally generated endocannabinoids. For example there is a compound produced in the body that is identical to THC called anandamide (AEA) or "bliss within." "These 'endocannabinoids' are released onto their receptors in a manner that appears to maintain homeostasis within the central nervous system."2 The two kinds of endocannabinoid receptor sites are termed CB1 and CB2. CB1 is one of the most ubiquitous neurotransmitters in the human body and is primarily found in the nervous system while CB2 is predominantly found in the lymphatic system.
The discovery of the built in ECS is helping to explain the complex entourage of effects produced by whole plant cannabis. Phyto and endo cannabinoids work together to activate the CB1 and CB2 receptor sites. The CBDiary.com entry on Apr. 20, 2011, explains how "CBD indirectly stimulates the production of anandamide by suppressing the enzyme fatty acid amide hydroxylase (FAAH). FAAH is responsible for breaking down anandamide, less FAAH means more anandamide remains present in the body for a longer duration. More anandamide means greater CB1 activation. CBD also stimulates the release of 2-AG, another endocannabinoid that activates both CB1 and CB2 receptors."3
Cannabinoid receptors represent an exciting new target for medical research, yet only confirm what patients have been saying for decades. Seriously ill people who have run the gamut of conventional medicine to no effect, and have sought to use cannabis through their doctor, have often been prescribed Marinol or Cesamet—the synthetic THC cannabis pills. The THC pills have been used by doctors as a third tier medication, citing a shortage of studies and assuming the limited therapeutic value of cannabis by default. Many doctors who have stayed in the closet about cannabis are only now learning from patients about the effectiveness of whole plant cannabis medicines made by dispensaries. Whole plant cannabis products have distinctive advantages over isolated cannabinoid drugs. In the book Marihuana: The Forbidden Medicine, doctors Lester Grinspoon and James Bakalar found that "whole cannabis causes fewer psychological side effects than synthetic THC, seen as symptoms of dysphoria, depersonalization, anxiety, panic reactions and paranoia."4
One of the most important distinctions between synthetic THC and whole plant cannabis is the presence of CBD. "CBD antagonizes THC and competes with THC to fill the cannabinoid receptor site."5 Drug companies are patenting cannabinoids like CBD as non-psychoactive medications for many conditions. A recently published study in Nature Neuroscience found that a CBD derivative "JWH133, a synthetic drug that activates the CB2 receptor, reduced intravenous cocaine administration in mice by 50-60%."6 This evidence suggests that other than a gateway to drug abuse, cannabis contains compounds that terminate seriously addictive behaviour. JWH133 is currently available online in wholesale for around $5000 a Kilo.7
Canadian companies IntelGenX and Cynapsus (formerly Cannasat) are now developing a synthetic CBD drug for market. "Modulyn is a CBD (cannabidiol) derived product that targets the endocannabinoid system to treat mood disorders such as schizophrenia, anxiety, and depression."8 Modulyn and its synthetic THC accomplice Relivar are delivered by a capsule that melts in the mouth. This provides partial absorption through the oral mucous membrane, quickening the onset of the effects and reducing the amount of drug metabolized by the liver. When swallowed, THC transforms into the metabolite, 11-Hydroxy THC, which is known to be more psychoactive than THC itself yet also "may be necessary for the mediation of analgesic activities."9 Modulyn and Relivar are part of a focus on new medications for the brain to treat neurological diseases such as Parkinson's.
Sativex, which is available in Canada by prescription, has a "1:1 dose ratio combination of CBD:THC."10 Sativex, unlike the aforementioned synthetics, is derived from cannabis plants grown in a laboratory, and is classified as a Botanical Drug Substance. However, Sativex is an alcohol based oromucosal (mouth) spray that has been shown to "cause irritations in the mouth in 20-25% patients in clinical trials."11 In a comparative study, former VICS owner Phillipe Lucas found that although superior to Marinol and Cesamet, Sativex is inferior to inhaled whole cannabis due to the delay of onset, and concluded that "the high cost (my total for this 5-day trial was 45 sprays, or $135 worth of Sativex) is sure to be prohibitive to many who might otherwise benefit from its use."12
Last year GW Pharmaceuticals sold the rights to Sativex to a Japanese company. "Otsuka's willingness to contemplate paying up to a quarter of a billion dollars in royalties and fees for one cannabis-based pharmaceutical with a less than overwhelming efficacy profile indicates that the total market for medical cannabis products is a multi-billion prospect."13
Figure 1. Pharmacological actions of non-psychotropic cannabinoids (with the indication of the proposed mechanisms of action).14
In American states where dispensaries are licensed, Cannabis Based Medicinal Extracts (CBMEs) are screened for safety by certified third party inspectors like steephilllab.com, in Mendocino County. These private laboratories assist dispensaries to ensure that their products maintain high standards. CBDscience LLC has developed three distinct cannabis tinctures: one "High CBD and low THC (4:1 ratio)," one "THC and CBD (1:1 ratio)," and one "high THC and low CBD (20:1 ratio)."15 These organizations are collaborating on "the Great CBD Hunt of 2011," and working together to collect and cultivate CBD rich strains.
Dispensaries often offer cannabis massage oils and salves extolling their anti-inflammatory, analgesic, and localized health benefits. The ECS is present in the skin and responsible for our natural protection from the drying effects of sun and wind. "It seems that the main physiological function of the cutaneous ECS is to constitutively control the proper and well-balanced proliferation, differentiation and survival, as well as immune competence and/or tolerance, of skin cells."16 Following the emergence of exciting research including "the recent discovery that topical cannabis preparations can be effective against MRSI, the deadly antibiotic-resistant flesh-eating disease."17 More interest is forming around the benefits of cannabis for the skin. Members of the CBC of C have reported rapidly healing third degree burns, clearing poison oak, and curing skin cancer.18
In recent years, the whole plant "synergistic shotgun" approach has gained ground over the single ingredient "silver bullet" method. The Aug. 2011 British Journal of Pharmacology: Cannabinoids in Biology and Medicine, Part 1 includes numerous articles exploring the nature of this plant medicines' dynamism.
In the article "Taming THC," reports scientists have discovered more than a hundred terpenes that "may contribute meaningfully to the entourage effects of cannabis-based medicinal extracts."19 The entourage effect of secondary compounds such as terpenes and flavanoids synergize and mitigate the active cannabinoids. The scientist who first isolated the THC compound, Raphael Mechoulam, suggests that "Investigations of the effect of the active component in the presence of its 'entourage' compounds may lead to results that differ from those observed with the active component only."
Cannabis Science Inc. is exploring the possibility that certain terpenes act as building blocks for the production of cannabinoids, with the hope that this will open up to cultivators the opportunity to manipulate cannabinoids to desired ratios. Many plant terpenes act synergistically with other terpenes and some serve to either catalyze or inhibit the formation of other compounds within a plant. Cannabis grown with care and attention to the curing process will contain more terpenes that could play a role similar to CBD in abating the psychoactive side effects of THC.
Anecdotal evidence suggests that the terpene alpha-pinene is alerting, limonene is "sunshine-y," and beta-myrcene is sedating. As the names suggest, pinene is abundant in pine needles and limonene in lemons. Traditional responses to cannabis overdose include pinene-rich black pepper, limonene-rich citrus, and calamus root high in myrcene. Myrcene is also found in hops (Humulus), the only other member of the Cannabaceae plant family. Ed Rosenthal, author of many books on cannabis, relates that the myrcene in mangos can increase the quality of low potency cannabis when eaten one hour before medicating. "Cannabis terpenoids and flavonoids may also increase cerebral blood flow, enhance cortical activity, kill respiratory pathogens, and provide anti-inflammatory activity."20
The rabbit hole gets deeper when we consider beta-caryophyllene (BCP), which is another terpene that contributes to the aroma and flavour. Studies show that this terpene, also found in other legal herbs, spices, and food plants, activates the CB2 receptor and acts as a non-psychoactive anti-inflammatory. Because it binds to a cannabinoid receptor […] and since it is an FDA approved food additive and ingested daily with food, it is the first known dietary cannabinoid.21 Leading the way on terpene identification is Green House Seed Company in Holland who have performed spectral analysis of each of their strains and developed a flavour wheel22 identifying 16 different terpenes to help individuals decide on their strain of choice.
In light of this, scientists isolating cannabinoids into synthetic compounds have to consider the terpene interaction as another variable potentially responsible for the plants therapeutic dynamism. Drug companies have been slow to keep up with this field of research, as many terpenes are FDA approved and therefore easy to obtain for testing.
It is becoming increasingly evident that the complex processes and transformations that occur in our bodies are intimately connected to the complex chemistry of the living cannabis plant, and it is through this complex relationship that comes the extensive list of medical treatments.
The symbiotic relationship between our bodies and this plant presents a natural mystery that is confounding the methods of modern medicines makers. The intimacy of the ECS and our health should not be underestimated and, in some cases, tinkered with. Rimonabant was designed to block the CB1 receptor in an attempt to produce the "reverse munchies" effect. It was released in France as an appetite suppressant named Acomplia, only to be rejected shortly after by the U.S. F.D.A. for causing anxiety, depression, and suicidal thoughts.
While drug companies attempt to patent isolated compounds, patients are better off vaporizing whole plant cannabis for fast relief, eating leaf-based medibles for a long sleep, or applying a massage oil to localize the effects. Cannabis dispensaries offer these options to patients at reduced cost, as they buy bulk ingredients and often receive leaf donations from their caring growers.
Although drug company proponents contest that isolated pharmaceuticals are safer than raw herbs, there has been a genesis of designer cannabinoid drugs that have made it onto the shelves of head shops and gas stations around the world. These compounds were formulated by Dr. John W. Huffman (JWH) in order to conduct experiments with CBD on human subjects without the use of plant derived cannabinoids. The research was funded exclusively by the National Institute of Drug Abuse whose narrow focus on "research to prevent and treat drug abuse and addiction"23 callously blocks whole plant medicine. Dr. Huffman reports that the chemical blueprints of his compounds were stolen and are now being reproduced around the world. JWH has stated publicly that these compounds are unsafe, and reports are emerging of users involved in accidents related to its impairment.
"Spice" smoking blends like K-2 are made into "incense" by spraying JWH compounds soaked in acetone (nail polish remover) onto dried herbs like damiana. At about $420 an ounce, these products are labelled "not for human consumption," yet are marketed as "Legal Weed," sometimes causing anxiety and dizziness while offering no medical value. These synthetic constructs continue to run amuck, as the specific profile of these duplicate cannabinoids are unclassified by the law. "Many of these cannabinoids have been developed specifically so they're not analogues of the other ones […] Theoretically there are thousands that could be developed."24
In light of this, it seems like another backfire of prohibition that synthetic copies of individual compounds originally found in the cannabis plant are being freely and widely distributed. Evidence continues to emerge in favour of whole plant medicine despite the narrowly focussed research approval standards of organizations like the N.I.D.A. that precipitated this legal loophole for opportunistic chemists. Despite the backwards policies of the current era of prohibition, cannabis may have surpassed all other plants in the breadth of its therapeutic value.
Scientists have only been learning about cannabinoid receptors since 1988. The deeper they explore this complex system the more it reveals about cannabis and our health. As patients continue to inform doctors about how cannabis has helped them, scientists arduously attempt to target these previously untreatable conditions. However, today, it seems clear that the synthetic cannabinoid medicines we have available fall short of the miraculous benefits attributed to whole plant products offered by community dispensaries.
While new synthetic cannabis products are tested and approved, the age old herb will continue to help people heal. May the continued vigilance of cannabis activists finally unveil the irrefutable truth that cannabis is indeed greater than the sum of its parts.
1. The Cannabinoid System, Dr. Robert J. Melamede, Ph.D. <www.hampapartiet.se/cb1cb2.htm>
2. Ligands that target cannabinoid receptors in the brain: from THC to anandamide and beyond. <www.ncbi.nlm.nih.gov/pubmed/18482430>
3. projectcbd.org/CBDiary.html#Apr20.114 Grinspoon and Bakalar, 1997 Marihuana: The Forbidden Medicine
5. NELSON, 2000 Hemp Husbandry
<www.rexresearch.com/hhusb/hh6thc.htm>
6. Brain cannabinoid CB2 receptors modulate cocaine's actions in mice <www.nature.com/neuro/journal/vaop/ncurrent/full/nn.2874.html>
7.<rcbuywholesale.com/component/virtuemart/?page=shop.product_details&product_id=180&flypage=flypage.tpl&pop=0>
8. <www.cynapsus.ca/melonhead/media/1255629139.pdf>
9. Analgesic properties of the tetrahydrocannabinols, their metabolites, and analogs <www.ncbi.nlm.nihhow do our bodies make endocannabinoids.gov/pubmed/1151992>
10. <www.hc-sc.gc.ca/dhp-mps/prodpharma/notices-avis/conditions/sativex_fs_fd_091289-eng.php>
12. PharmaCannabis, Lucas 2006 <www.thevics.com/publications/Sativexarticle02-22-06.pdf>
13. <www.cannabisscience.com/corporate-info.html>
14. Chart of the Pharmacological actions of non-psychotropic cannabinoids <http://cannabisinternational.org/info/Non-Psychoactive-Cannabinoids.pdf>
15. <http://cbdscience.com/>
16. The endocannabinoid system of the skin in health and disease: novel perspectives and therapeutic opportunities. <www.ncbi.nlm.nih.gov/pubmed/19608284>
18. Cannabis Salve, Testimony <www.youtube.com/watch?v=49oC_WppadU>
19. Russo, 2011 Taming THC: potential cannabis synergy and phytocannabinoid-terpenoid entourage effects <onlinelibrary.wiley.com/doi/10.1111/j.1476-5381.2011.01238.x/abstract>
20. 2001 McPartland and Russo, Cannabis and Cannabis Extracts: Greater Than the Sum of Their Parts? <www.cannabis-med.org/data/pdf/2001-03-04-7.pdf>
21. Beta-caryophyllene is a dietary cannabinoid <www.ncbi.nlm.nih.gov/pubmed/18574142>
22. <www.greenhouseseeds.nl/shop/flavour-wheel.html>
23. <www.nida.nih.gov/StrategicPlan/StratPlan10/Index.html>
24. Designer drugs a cat-and-mouse game <www.nzherald.co.nz/health/news/article.cfm?c_id=204&objectid=10738810>
Tagged cannabinoid, cannabinoids, ECS, entourage, Medicinal, peroxisome proliferator-activated receptor, plant, terpene, transient receptor potential
Owen has been writing for the Cannabis Digest since 2009, covering a wide range of topics related to medical cannabis. Owen's articles are closely related to his constitutional challenge to legalized cannabis edibles extracts and oils. He is the founder of Ethical Growth Consulting www.ethicalgrowth.ca
Activism Archive Blog Full
'O Cannabis Tree'
December 21, 2014 December 21, 2014 Ted Smith
(Sung to the Tune of O Christmas Tree) by Ted Smith Oh Cannabis Tree, Oh Cannabis Tree, Thy buds are so enlightening You get me high when summer's here, but also when 'tis cold and drear. Oh Cannabis Tree, Oh Cannabis Tree, Thy buds are so enlightening Oh Cannabis Tree, Oh Cannabis Tree, […]
Patients Await Mernaugh Appeal Case
July 10, 2012 May 3, 2014 Al Graham
Matt Mernaugh and Paul Lewin hopefully deliver blow to cannabis laws By Al Graham In early May, I headed to Toronto to attend the Ontario Superior Court case of Matt Mernaugh. This case is about an ill Canadian who proved in an Ontario Court that he could not access the Health Canada medical marijuana program, […]
EDITORIAL: The Clear Green Skies
April 24, 2012 May 3, 2014 Andrew Brown
Andrew Brown Editor It's pretty amazing being able to sit back and watch the wall of prohibition self destruct. Well, perhaps it isn't all self destruction, rather decades of dedicated activism persistently pointing out the deceit that the prohibition of cannabis was built on, but nonetheless it is the bold lies of the past eighty […]
UVic Hempology 101's Letter to VP of Finance
Paving The Way With Hempcrete


SEYMOUR -- Plans are advancing for a new convenience store and gas station at the former Sweets & Eats and Shell sites downtown.
Economic Development Director Fred A. Messore said the two properties on New Haven Road, or Route 67, are under contract with an unnamed developer.
"All the terms of the contract have been agreed upon," Messore said.
An application will soon be filed with land-use boards for review and approvals, Messore said.
"We're very excited about it. Not only will the new business create jobs, but this property is a gateway into the town," Messore said.
Messore said he's been meeting with the developer for several months. The site is a gateway to downtown, off Exit 22 of southbound Route 8.
"We were very cognizant to make it a signature-looking building because the property is so visible," Messore said.
Messore said the store and concrete station will be demolished. The former Shell closed several years ago and is surrounded by a chain-link fence. Sweets & Eats closed around 2011.
Messore said the developer is under contract to combine the two sites. The convenience store will have a drive-through.
In other development news, Messore said plans are moving ahead for the former Seymour Lumber on Bank Street to be sold and demolished.
Owner Tom Tkacz is working with a realty agent in getting the property sold, and has "a couple of interested parties," Messore said.
"The goal is to get the building down, as it's a blighted property," Messore said.
Carolyn's Weenie Wagon, a hot dog spot that moved to the former lumber property in 2010, was given two months by Tkacz to relocate.
Messore said the town is working with owner Carolyn Schumacher to find a new location.


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Jonatan Habib Engqvist
Architecture / Curating / Literature / Performing arts / Research / Visual arts / Writer
29 Mar — 25 Apr 2023
Image: Bjargey Olafsdottir, 2022
Jonatan Habib Engqvist is a curator, author and occasional teacher. He is the Co-editor of Ord&Bild, curator of experimental projects and over 50 exhibitions on 4 continents including international biennales and festivals Art D-0 ARK Underground, VR Pavilion at 58th Venice Biennale, Cycle Music&Art Festival Berlin/Reykjavík, Survival Kit Riga, Sinopale in Turkey, Momentum biennale in Moss, Norway, and Reykjavík Arts Festival. He is Founding director of Curatorial Residency in Stockholm, previously manager of visual art at Iaspis, curator at Moderna Museet and employed at Royal Institute of Art, Stockholm. His writing has been published widely in several languages in books and catalogues around the world.
I plan to update myself on the Finnish art scene, by spending a longer period than just a couple of days in Helsinki. I look forward to making some studio visits at HIAP and in Helsinki, and to organizing a talk/event in Swedish connected to Ord&Bild. I may possibly lecture at KUVA.


At Walnut Mission Control we've got two or three days to go. We're checking equipment, running through protocols and procedures, making sure our supplying of Rooibos tea and moisturiser are stowed.
I personally have also bought an authentic Breton Shirt – while accepting it might be more authentic if I bought it in Breton I was too excited to wait and I'm not sure where Breton is or if we'll be driving through it at a time when the Breton shirt shops will be open.
And as two of my more 'scientific' friends pointed out in different ways we have in the region of 20 billion times (yup 'billion') more computing power on the Walnut's module/motorhome than the Apollo 11's landing module. I know the pedants amongst you will work out, that if you follow the logic, the Walnuts should be a least a billion times more spectacular than Apollo 11. However, if you are familiar with the Walnuts you'll know we're not really astronauts and I don't think we've ever been discribed as spectacular. – some of the walnuts are qualified space cadet but not me.
To the heart of the matter. Me, Buzz Allwright, Donald T Kirk and Yuri GaMuirhead are metaphorically leaving Mission Control and on a buggy out to our ship. We've said our farewells to Planets Berkshire and Glasgow and we're counting down for takeoff which involved leaving a bit early so we don't get stuck on the M25 on our way to Eurostar.
So our bags are packed, we're ready to go and already I'm so lonesome I could cry.


Pop in to our Dundrum branch to find out about our new projects and latest appeals, or have a browse through either of our shops for high quality second hand clothes, shoes, books and toys. Feel free to take a look at our hand made goods made by Syrian women and supporting Syrian refugee micro businesses whom we work closely with. Purchases made at either of our charity shops go to support our latest relief appeals providing humanitarian aid and relief across the world.
All are welcome and will be met with a smile. Clothes donations are accepted in both of our branches as well a our clothes banks which are dotted around the country. Please note all clothes and goods donations are either sold at the shops or become part of a container shipment which are dispatched around the world providing clothing to the needy.


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Home BREAKING NEWS Community activist Ramesh Dalchand Kalicharran passes away
Community activist Ramesh Dalchand Kalicharran passes away
Ramesh Dalchand Kalicharran (Courtesy: Indian Diaspora Council International)
NEW YORK – Community advocate, businessman and philanthropist Ramesh Dalchand Kalicharran passed away on Sunday, December 3, in New York. He is survived by his wife Judy, his children Jagdesh, Nadesh and Romanee, his grandchildren, his siblings, extended family, friends and associates.
The Indian Diaspora Council International (IDC) joined in solidarity with organizations, institutions, agencies, and individuals in the U.S., Guyana and other countries in Kalicharran's mourning, said a press release.
"Ramesh Kalicharran was an outstanding community stalwart. He was a prominent and well recognized cornerstone of the community, having pioneered several programs and events which promoted the interests of Indo-Caribbean people in New York and the Caribbean. He is widely recognized for his advocacy, philanthropy and exemplary contributions to charitable and community causes. Ramesh D. Kalicharran was an active member of IDC and recognized for his exemplary contributions to his community and the promotion of Indian culture and heritage. He was an icon among Indo-Caribbean people with a long lasting legacy of selfless service. He will be greatly missed," IDC said in a statement.
Kalicharran was born on April 7, 1949 in Guyana and was the eldest of eleven children born to Ramdayal and Mangani Kalicharran, the second generation of Indians living in Guyana who trace their roots to the state of Uttar Pradesh in India.
Though he was Indian, Kalicharran saw himself beyond such limits as he continuously and relentlessly promoted the welfare of his Indo-Caribbean community, as well as others.
"Kalicharran excelled in every field of endeavour and became an outstanding role model for our youth, excelling academically as well as in his extra-curricular activities," the release noted.
He immigrated to the United States in 1970 where he married Judy in 1974. They have three children and two grandchildren.
Kalicharran entered the real estate business, started a driving school and then launched an innovative concept called the Kali Bharat Yatra Tours (KBY) for Indians to discover and re-connection with their roots in India.
Popularly known as Kali, Kalicharran has received recognition for his contribution in Guyana, where he was an ambassador, as well as in New York, including several citations, the Asian-Indian Award and the Indo-Caribbean Award.
A citation to Kalicharran from the Queens Borough President best showcases his achievements.
"As an outstanding business and civic leader of the Guyanese community in Queens, you have generously given time, talent, and resources toward the betterment of your community and the preservation of its cultural heritage. I, President Shulman, wish to express my sincere gratitude for your valuable contribution to the cultural richness and vitality of our borough," he said.
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Menzie Chinn reports more dispatches from Wisconsin, this time on recent Congressional testimony by Wisconsin's Governor Scott Walker. It's clear the union-busting efforting in Wisconsin is NOT about the state budget or saving money. It's ideological. It's opposition to unions period. The budget is and was irrelevant. It was pure propaganda by Walker and the Wisconsin Republicans to cover their real objectives. This is shock doctrine stuff. Neo-liberals used to force this kind of undemocratic social change onto third-world and developing nations. Now they do it here.
Kucinich said he could not understand how Walker's bill to strip most collective bargaining rights from nearly all public workers saved the state any money and therefore was relevant to the topic before the committee, which was state and municipal debt.
When Walker failed to address how repealing collective bargaining rights for state workers is related to state debt or how requiring unions to recertify annually saves money — one of the provisions in Walker's amended budget repair bill — Kucinich tried one more time.
"It doesn't save any," Walker said.
"That's right. It obviously had no effect on the state budget," Kucinich replied.


text:
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Also set padding and margin to 0 to remove spaces from the side
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A: If I understand the issue correctly, this might help:
background-size: cover;

A: Add the
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duplicate here


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Kelly Takes Blame For No. 9 Notre Dame's 41-8 Loss At Miami
Filed Under:Brian Kelly, notre dame
By JOHN FINERAN, Associated Press
SOUTH BEND, Ind. (AP) — Notre Dame coach Brian Kelly's worst fear came true Saturday night in the No. 9 Irish's blowout loss at Miami. Miami's 41-8 thrashing of the Irish at Hard Rock Stadium.
The object that left a window damaged on one of the Notre Dame team buses arriving at Hard Rock Stadium didn't bother Kelly as much as what he saw during the game.
"Yeah, if I saw the turnover chain passed around (Miami's) bench like Gatorade, that was probably going to be my biggest concern. Unfortunately, that came to fruition," Kelly said Sunday before his 8-2 team began preparations for its final home game this Saturday against Navy.
The turnover chain — a gold chain with a large orange-and-green "U" hanging from it that is instantly awarded to a Miami player for coming up with a takeaway — was handed out four times to celebrate the three interceptions and fumble recovery that the No. 2 Hurricanes (9-0, No. 7 College Football Playoff) turned into 24 points against the now No. 9 Irish (No. 3 CFP) whose national championship hopes likely ended.
The turnovers — three by starting quarterback Brandon Wimbush before he was replaced in the second quarter by Ian Book, who threw an interception that was returned for a touchdown just before halftime — were more disabling than the hoopla and atmosphere leading up to the game.
"It was a big game," Kelly said. "We play in a big-game atmosphere at Notre Dame but this one was a little different. A number of these kids hadn't played in a game of this magnitude since maybe the Clemson game (a 24-22 loss on Oct. 3, 2015) and I don't know that there were many defensive players on the field for that. I've got to do a better job of making sure that they're in the moment."
The Irish didn't force a turnover Saturday for the first time this season but surrendered 374 total yards, just under the 375.6 yards that had been averaging. It was the turnovers by the offense, which managed just 109 rushing yards, 215 fewer than its average, that proved insurmountable.
"You've got to protect the football and we did not do a very good job protecting the football," Kelly said.
Wimbush, who returned in the third quarter, ended his day with 119 yards and one touchdown (a 14-yarder to tight end Alizé Mack) on 10-of-21 passing and was sacked five times, with Miami recovering a fumble that led to its final touchdown.
"(Brandon) obviously didn't perform at the level that he wants to perform at and that he quite frankly needs to perform at," Kelly said. "I think he gained a lot of understanding of what he needs to do to lead this football team."
The interceptions were Wimbush's first since a 49-20 victory at Boston College that started the seven-game winning streak which Miami ended. The fumble was his fourth and the second straight week he has lost one. Wimbush played the game with a pad and glove to protect a contusion on his left (non-throwing) hand he sustained against Wake Forest that Kelly said wasn't a factor.


Download the latest Tax Organizer below (PDF), which will help aid you in the gathering of your tax information. If you have any quesitons, please do not hesitate to call our office at (586) 204-2020.
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You can download our Tax Organizer by clicking on the "Download (PDF)" button at the top of this page.
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Camshafts & Cam Cores, Cam Misc.
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Cam Shafts For British Sports Car Engines, ALL APT Cams Ground Here In Our Own Shop. Ground Using New CNC Produced Masters Made From Our Own Design Data. WE DO NOT MAKE OUR MASTERS BY COPYING SOMEONE ELSE'S CAM THAT IN ALL LIKELYHOOD IS ITSELF A COPY!
Camshafts : Cam Cores, Cam Misc.
Pin Drive (948-1098) Regrind, 234@0.050" Lobe Lift 0.295"
Nominal Duration 266 Degrees, Lobe Lift 0.270", Large Jrnl.
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2015 - Self Released
Feral are an Oakland, California based trio who formed in late 2013 with Cindy Emch of Rhubarb Whiskey, Vagabondage, Sinners Tonic and Portland Wine Drinkers Union on guitar and vocals Norman Carley from Jerk Church on guitar and vocals and Ed Cagnacci from Officer Down on upright bass.
'Aromatic Bitters' is their first album, at least together, and they have been featured on Couch by Couchwest last year and this, as well as touring the West Coast and Canada. The reference to Couch by Couchwest helps sum up this band that have no airs and graces or pretence at being cod 'rock stars.' C by C is an online music festival for those who don't have the budget for South by Southwest and is an event that is pleasingly starting to catch on. There are no fanfares; just far from plain and even further from simple music by people who feel the music and live their lives far removed from those promoted by record companies. They are described as an 'Americana' band, no bad thing to be placed under this rootsy catch all umbrella, which means they can stretch and twist themselves all over the even broader 'roots' genre!
They have written some unusual but strong catchy melodies for an album that can't really be defined as 'country' or the myriad of other titles that are linked to country but there is a powerful 'rurality' to their music and thematically there are some strong country elements. In some ways this album can be linked to those spooky recordings made in the 1920s that, because they are so far removed from us, take on an added sinister otherworldly atmosphere. That is probably as accurate a summing up of this incredible album as I can come up with and yet after numerous listening sessions Cindy and partners seem to be developing and deepening their sound as I listen to the record! Impossible maybe, but the live feel is so real that you can imagine each play being a new live performance during which they make subtle little changes. In some ways a 21st century update of 'front porch' music!
Whilst much of the album is dark and often surreal, everything about the recording has a powerful integrity, with lyrics that have a potent, if dark, poeticism, strong melodies and vocals that cannot be ignored. They may not always be what many people expect of 'contemporary country' vocals but in my world they are not only welcome but are absolutely necessary to alleviate much of the 'wallpaper' music that passes for heartfelt and rootsy! Whilst Cindy's vocals have an appealing melodicism there is a noticeable underlying strength and determination that helps to root the trio to somewhere close to the contemporary world whereas Norman Carley's vocals are a force of nature that on occasions make Tom Waits sound like one of the Kings College choirboys who are so beloved at Christmas! Don't think though that there is only that rawness. His harmonies with Cindy are clashing but appealing and provide excellent and accurate colour for the lyrical content. He does have that deep, dark and quite incredible rawness but is also capable, as he proves on this recording, of moving into a slightly less raw, Johnny Cash territory. For the two vocalists to be able to project these often dark unsettling songs an incredibly solid foundation is an absolute necessity. They are fortunate to have on board Ed Cagnacci whose bass playing not only supplies that, but also adds to the musicality of these sometimes epic songs.
The instrumentation is all acoustic and there is plenty of edgy punk attitude from this trio who have far more musical ability and much better ideas than most punk bands were ever capable of coming up with. The fourteen songs are all band originals and whilst most of the themes have been explored before very few have told the stories with as much grit and reality as this trio. In fact, I don't think these songs are as much 'stories' as images of the sometimes harshness of life, perhaps on occasions theirs, with no sanitization or polish used to lessen the impact or to smooth the rough edges.
The album gets under way with a nice balanced acoustic guitars intro on Done And Gone before Cindy starts in with her vocal, soon joined by the dual harmonies of the other two band members on a powerfully melodic paean to love on which the suspicion that Norman Carley's vocal style is different to what you may be used to starts to take shape! Loose Ends has another nice guitar sound on the intro with a soft but powerful bass and Cindy's lead vocal before Norman Carley's duet vocal joins her on a song of a past love that definitely wasn't going anywhere despite the desire to have seen it through. Carley's vocal is the perfect counterpoint to Cindy's classic style bringing a depth and even more character to an album that is entirely different to any other country, Americana, etc album I've ever heard. There are not too many vocalists with Carleys whiskey soaked, gravelly voice, but it is not just a 'sound effect,' there is melodicism and character to burn in the vocal pipes of someone who on occasions makes Tom Waits sound like the already mentioned 'choir boy.' On About You there is the usual melodic acoustic guitar sound supported by the dynamic bass foundation for Cindy to lead another song with her evocative vocal style on the story of a couple driven apart and from the vehemence in their vocals, absolutely no chance of redemption! Carleys vocal alongside Cindy's is full of the passion and often scary tone of a mad country preacher who no one is going to argue with, again adding depth to an excellent song. Fluevogs and Bourbon treats the listener to a lead vocal from Carley that leaves Tom Waits in his wake on a melodic but dark tale on which Cindy contributes otherworldly harmonies as a counterpoint to the lead. Doomed Waltz again has Norman Carley on lead vocals with a performance that is almost restrained but still deep and dark, again counterpointing Cindy's vocal style on an 'almost' love song and as with other songs on the album the darkness of the vocals and to a degree the lyrics is countered by the melodic chiming of the acoustic guitars and deepened by the upright bass sound. Final mention has to go to the epic, both musically and time wise (eight minutes!) Holy Man, with Carley's slow moody, deep, dark, lead vocal accompanied by the melodic acoustic guitar, rooted by the powerful deep booming bass on an otherworldly tale that has some of the darkness alleviated by the lightness of the guitar which is never overwhelmed by the bass or vocal. And yet, at the same time that lightness highlights the darkness on a sinister tale that in some ways sums up a band that exists outside of our comfortable contemporary lifestyles, always pushing and nagging at accepted boundaries, perhaps in life as well as their music?
When we talk about 'real country music' or even 'real music,' this band, with their dark yet realistic songs whose power is emphasized by their sometimes uncomfortable attack virtually define both terms. There is no artifice; just fourteen tremendous snippets from life that for some may be hard to take, but none the less is an hour of music that is incredibly rewarding. I wouldn't be a bit surprised if an ever growing cult sprang up around Feral, so buy the album, soak it up and you can be in at the start of something highly original and not manufactured by television!
http://www.musiciansareferal.com/