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Brightsurf
An example is a study published in PLOS Pathogens describing how Brazilian researchers analyzed blood cells from patients infected with chikungunya virus. With the aid of techniques such as complex network analysis, artificial intelligence and machine learning, the group identified gene signatures associated with the disease - sets of genes whose expression is altered by interaction with the virus. They then investigated the role played in cells by the involved genes and determined the importance of these genes to efforts to combat the virus.
Conducted in Brazil, the research was supported by São Paulo Research Foundation - FAPESP. The principal investigator was Helder Nakaya , a professor at the University of São Paulo's School of Pharmaceutical Sciences (FCF-USP). Researchers at the same university's Biomedical Science Institute (ICB-USP) and its Ribeirão Preto Medical School (FMRP-USP), as well as colleagues at Butantan Institute and the Public Health Central Laboratory of Sergipe, among others, also contributed.
"We also identified a set of genes that show during the acute phase whether the patient is likely to develop chronic arthralgia [joint pain and inflammation], a relatively common condition in people infected with chikungunya. However, this finding has yet to be confirmed by future research based on a larger number of samples," Nakaya told.
The first step was an analysis of the samples' transcriptomes, comprising all molecules of messenger RNA (which encodes proteins) as well as noncoding RNAs (which do not produce proteins but perform a regulatory role in the genome) expressed in red blood cells, white blood cells and platelets. By quantifying the transcript levels in the samples, the researchers were able to measure the activity levels of 20,000 genes and determine whether their expression increased or decreased during infection; these findings were also compared with results for the control group.
"We focused on protein-coding genes [which express messenger RNA] because their role is easier to interpret. It's relatively easy to know whether they encode cell receptors or transcription factors, for example. In this way, we were able to enhance our understanding of the pathogenesis of chikungunya - how the virus affects cells and which defense systems are activated in response to infection," Nakaya said.
The finding was validated in experiments with mice performed in partnership with Dario Zamboni , Full Professor at FMRP-USP. Both Nakaya and Zamboni are affiliated with the Center for Research on Inflammatory Diseases (CRID), one of the Research, Innovation and Dissemination Centers (RIDCs) funded by São Paulo Research Foundation - FAPESP. The CRID is hosted by FMRP-USP.
"We noticed that the gene signatures of both diseases were similar to a considerable extent but that some genes were specific to chikungunya. These can be explored further in drug development research," Nakaya said.
"In this case, our aim was to discover the difference between arthritis caused by the virus and autoimmune arthritis. We wanted to identify any genes that were specific to the viral infection," Nakaya explained.
The researchers then performed gene coexpression analysis using CEMiTool , a software package developed by Nakaya with FAPESP's support. The aim of this analysis was to understand how the genes interact with each other within the complex network that exists in every cell, forming signaling pathways and metabolic pathways.
"We were able to identify eight main coexpression modules [genes with similar response profiles]. We also identified the network hubs - the genes with the most connections and, hence, the most promising targets to explore for drug development purposes," Nakaya said.
"Our research enabled us to produce a list of potential therapeutic targets, and we're now cross-referencing these findings with a database of active compounds. This cross-referencing is being done computationally but on the basis of experimental data compiled from published studies that have pointed to drugs capable of interfering with these genes of interest," Nakaya said.
Nakaya was supported by FAPESP via a Regular Research Grant and a Young Investigator Grant . The study was also supported via CRID and another RIDC, the Center on Toxins, Immune Response and Cell Signaling ( CeTICS ).
The São Paulo Research Foundation (FAPESP) is a public institution with the mission of supporting scientific research in all fields of knowledge by awarding scholarships, fellowships and grants to investigators linked with higher education and research institutions in the State of São Paulo, Brazil. FAPESP is aware that the very best research can only be done by working with the best researchers internationally. Therefore, it has established partnerships with funding agencies, higher education, private companies, and research organizations in other countries known for the quality of their research and has been encouraging scientists funded by its grants to further develop their international collaboration. You can learn more about FAPESP at http://www.fapesp.br/en and visit FAPESP news agency at http://www.agencia.fapesp.br/en to keep updated with the latest scientific breakthroughs FAPESP helps achieve through its many programs, awards and research centers. You may also subscribe to FAPESP news agency at http://agencia.fapesp.br/subscribe .
Fundação de Amparo à Pesquisa do Estado de São Paulo
Fonte: http://www.brightsurf.com/news/article/091619492276/acute-chikungunya-infection-studied-at-the-molecular-level-in-brazilian-patients.html
Bioquick News (EUA) 7thSpace Scienmag Science Magazine (Reino Unido) Medical Xpress (Reino Unido) Agenparl (Itália) Science Codex All My Family Care


"Haitham Al-Haddad was born in Saudi Arabia"
Haitham al-Haddad was born in Saudi Arabia. Little information is known about the Shaykh but he has got an esteemed title in the United Kingdom's Shariah Council. Haitham is an activist and his presence can be mainly seen in the Board of Shariah. The Shaykh also contributes a lot to the website Islam21c.com where he tries to tackle modern issues in the West and Islam.


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Go to deals
Consumer & Retail | TMT
Paddy Power plc has merged with Betfair Group plc
Two of the fastest growing online betting operators — Paddy Power plc and Betfair Group plc — have merged. The new entity, Paddy Power Betfair plc, is worth c. US$11 billion, making it one of the world's largest public online betting and gaming companies by revenue with enlarged scale, capability and distinctive complementary brands.
Paddy Power is an international multi-channel betting and gaming group, offering online services and a chain of retail outlets throughout Ireland, Northern Ireland and Great Britain.
Betfair is an innovative online betting and gaming operator, which pioneered the betting exchange model in 2000, changing the landscape of the sports betting industry.
Paddy Power Betfair has a market-leading presence in the UK, Ireland, Australia and the USA, as well as a range of B2C and B2B operations across Europe. Since the initial proposed merger announcement, the combined equity value has increased by c. 70%, reflecting the resounding shareholder and market support for the transaction. Paddy Power Betfair will join the FTSE 100 index and will also be a constituent of MSCI European large-cap indices.
The merger was implemented by Paddy Power plc making an all paper offer for Betfair Group plc. Oaklins' team in Ireland advised Paddy Power on, inter alia, negotiation of the merger terms, deal management, financial analysis, development of the investment story and stakeholder management. Our Irish team has been a longstanding advisor to Paddy Power, advising on public offer issues, acquisition strategy and the acquisition of Sportsbet Australia (alongside Oaklins' Australian team) and Cayetano.
M&A buy-side
Talk to the deal team
Tom Godfrey
Oaklins IBI
View profile Get in touch
Ghost has been acquired by Picture Shop
The private shareholders and founders of Ghost A/S have sold the company to Picture Shop.
Liana Technologies has been acquired by Ilkka-Yhtymä Group
The shareholders of Liana Technologies Oy, Finland's largest cloud-based marketing and communications software provider, have sold a majority stake in the company to Ilkka-Yhtymä Group.
LeadDesk has received strategic advice on Nasdaq First North Helsinki
Leaddesk has received strategic advice on Nasdaq First North Helsinki.

redpajama_set_name: RedPajamaCommonCrawl


text:
NewsLaw and Justice
Venezuelan Ex-Magistrate Flees to Miami, Pledges to 'Collaborate' with US Authorities
Venezuela's Supreme Court claims Christian Zerpa fled a sexual harassment investigation.
zerpa.jpg.1180x600_q85_box-0631180663_crop_detail.jpg
Ex-magistrate Christian Zerpa (Reddit.com)
By Paul Dobson
Jan 7th 2019 at 7.11pm
Merida, January 7, 2019 (venezuelanalysis.com) – One of Venezuela's thirty-three Supreme Court magistrates has fled to the United States, despite being named on Washington's sanctions list in 2018, adding to recent pressure against Caracas.
Christian Zerpa, who presided over the Electoral Council of Venezuela's Supreme Court (TSJ), appeared in Orlando, Florida with his wife and daughter Sunday, conceding an interview to right-wing news agency El Venezolano TV Miami (EVTV). Zerpa is a member of the ruling United Socialist Party of Venezuela (PSUV), serving as a leading lawmaker in both the National Assembly and the PARLASUR. Since 1998, he actively campaigned for the election of both ex-President Chavez and current President Maduro.
The defection comes only days before President Maduro is due to be sworn in for his second term by the TSJ on January 10.
In explaining his decision, Zerpa assumed a firm anti-Maduro position, claiming he was not prepared to form part of the institution that swears in the president on the grounds that he deemed the May 20 elections not "competitive."
"I believe (Maduro) does not deserve a second chance because the election he supposedly won was not free and competitive," he told EVTV reporter Carla Angola.
When asked about the timing of his desertion, Zerpa only responded that he had delayed until now in order to "arouse less suspicion."
During the interview, Zerpa took aim at Maduro's government, denouncing alleged abuses of power and persecution. He went on to state that he plans on "collaborating with the US authorities," without offering further details.
Since his interview, Zerpa has been formally dismissed by TSJ President Maikel Moreno, whom Zerpa described as a "criminal."
In a TSJ statement, Moreno revealed that Zerpa, had been under investigation since November 23, 2018 for "sexual harassment, psychological violence, and lascivious acts in the workplace," which had allegedly led to many female employees quitting. These accusations, the court claims, pushed Zerpa to abandon the country "to avoid justice and so that his crimes may remain unpunished."
Appointed to the top court by the outgoing PSUV-majority National Assembly in 2015, Zerpa is most controversially known for authoring the 2016 TSJ ruling which declared the opposition-controlled National Assembly in contempt, temporarily nullifying its mandate over a series of functional irregularities deemed illegal.
Zerpa was alongside other magistrates and Maduro's wife who were personally named as "individuals responsible for the worsening democratic situation in Venezuela" by the US and Canada last year. Under the sanctions, Zerpa and other officials are banned from entering the US and can have their assets frozen there.
He is the latest in a series of high-profile state officials facing criminal prosecution to have fled Venezuela, including former Attorney General Luisa Ortega Diaz and ex-oil czar Rafael Ramirez, both of whom are under investigation as part of an anti-corruption drive.
US authorities have yet to provide any information regarding whether Zerpa will receive political asylum or the status of sanctions against him.
Edited by Lucas Koerner from Philadelphia.
Ex-Oil Czar Threatens Venezuelan Government Following Interpol Capture Order
Rafael Ramirez told right-leaning newspaper La Razon he has "confidential information" about alleged Maduro administration corruption.
Venezuela Probes Ortega's Handling of Financial Crimes amid New Odebrecht Corruption Allegations
Venezuelan authorities unveiled Wednesday a probe into the Public Prosecution's handling of financial crimes under the tenure of Luisa Ortega, as the country's...
Aug 3rd 2016
Venezuelan Supreme Court Blocks Swearing-In of Amazonas Legislators
Venezuela's Supreme Court (TSJ) declared unconstitutional Monday a move by the opposition-led National Assembly to swear-in three lawmakers from Amazonas state...
Venezuelan Supreme Court Blocks Parliamentary Motion to Remove Justices
Venezuela's Supreme Court (TSJ) struck down Tuesday a parliamentary commission seeking to unseat the high court's 13 justices over alleged constitutional...
Venezuelan Supreme Court: "National Assembly is Void"
Venezuela's Supreme Court of Justice (TSJ) has ruled that the country's National Assembly is void, after the legislative body violated a previous court order...
Venezuela Probes Foreign Bank Accounts Amid Corruption Allegations
The Venezuelan public prosecutor's office announced on Tuesday it would probe Venezuelan holdings in offshore accounts, as part of a continued defense effort...


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Armed police evacuate Oxford Circus as people run from the scene
They are treating it as a terrorist attack
Armed police have evacuated people from Oxford Circus tube station in London and reports say people were seen fleeing from the scene.
Witnesses say that gunshots were heard at a nearby pub.
British Transport Police are warning people to avoid the area.
Footage from the scene shows panicked people running down one of London's most packed shopping streets.
Scotland Yard told The Guardian: "Police have responded as if the incident is terrorist related.
"Armed and unarmed officers are on scene and dealing along with colleagues from British Transport Police."
The news comes on one of the busiest days for public transport in not only London but across the world as Black Friday shoppers make their way home.
A Transport for London spokesperson told The Daily Star: "Oxford circus is heavily restricted on all approaches to a police incident. Avoid area if possible."
Musician Olly Murs was in Selfridges at the time and shared updates on his Twitter that he heard gunshots.


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Home >News
KILDARE SCHOOLS ENCOURAGED TO SIGN UP FOR IRELAND'S LARGEST ENTERPRISE PROGRAMME
Secondary Schools across County Kildare are being encouraged to sign up for this year's Student Enterprise Programme. An initiative of the Local Enterprise Offices, the country's largest enterprise programme for second level students begins its 21st year and over 300,000 students have taken part since it began.
Every year around 25,000 students take part from almost 500 schools all across the country, competing in the Junior, Intermediate and Senior categories. Participants learn how to create and run their own business, picking up key skills along the way such as ideation, marketing, finance and sales and it's open to all secondary schools. Recent ambassadors for the programme have included Derval O'Rourke, Josh Van Der Flier and Limerick All-Ireland winner Sean Finn.
The programme is run through the network of Local Enterprise Offices, supported by Enterprise Ireland and the local authorities, with local coordinators in every area to support teachers and students through the year of the programme, which helps foster entrepreneurship in students and gives them key skills they can bring with them into later life. The programme is open to all secondary school students from 1st year through to 6th year.
Kildare has a strong track record in the Student Enterprise Programme, with Students from St.Mary's College in Naas winning an award at the National Finals in Croke Park in 2019 and Kilcock students winning a National Award at the Final in 2018.
Sonya Kavanagh, Chief Executive of Kildare County Council said; "The aim of the Student Enterprise Programme is to instil a little bit of entrepreneurial spirit in every student that takes part. Kildare County Council's Local Enterprise Office works closely with schools around Kildare to help spark ideas but also to keep a focus on what make sales."
She continued "The skills students gain are invaluable and to see the amazing ideas, year on year, many of which go on to become viable businesses, is inspirational not only to fellow students but to anyone involved in business and entrepreneurship."
Kildare county finalists last year were students Mairéad Kehoe, Saoirse Povey & Sarah Girvan-Hendy of St. Wolstan's Community School, Celbridge with their mini company Horseshoes 4 U.
The overall winners at the National Final were Barrelda from Meath in the Senior Category with their business recycling poly drums from the farm for use as meal troughs and calf teat feeders.
Since the Student Enterprise Programme began in 2003, over 300,000 students have taken part, learning key skills on how to create a business idea, start a business and grow a business. The Student Enterprise Programme also has a new range of online resources for 2022/2023 at www.StudentEnterprise.ie, which will feature regular blogs and houses a full range of Student Enterprise resources for students and teachers.
Interested in participating? Contact Us
Image: Kildare County Final Winners, St. Wolstan's Community School, Celbridge with their mini company Horseshoes 4 U Students: Mairéad Kehoe, Saoirse Povey & Sarah Girvan-Hendy


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The New Thai Kid In Town
Twin Kitchen is a Thai restaurant that opened in the building that once housed Greenhouse Grille. I think once people hear about this place, it will need to move to a bigger building.
Playing "What If?" With The American Southwest
Just suppose that all of the southwestern United States had remained in Mexican hands. Would the Mexicans have done any better with it than they have with the present confines of Mexico?
Everybody Wants To Join The Club
Bill Graber from Ohio wants to be a lesbian. Tom MacMaster of Edinburgh Scotland wants to be a lesbian. Both of these fine upstanding literary blogispherical men were recently "outed" for being HETEROSEXUAL men.
Goose Island's Innocuous Beer
Goose Island Honker's Ale is brewed by Goose Island Beer Co. in Chicago. This brewery is one of the latest acquisitions of the Belgian beer giant Anheuser-Busch InBev.
Advice Advice Goddess
The Shopping Cart Before The Horse
It's a really bad idea for a guy to give flowers to a girl he's just meeting, unless she's just won the Kentucky Derby. In that case, he could also slip her a carrot and slap her on the rump.
States Of The Union
Same-sex marriage is now permitted in six states with New York passing the Marriage Equality Act by a vote of 33-29 on June 24.
Cool Off With Hot Summer Jazz
The 13th season of the KUAF Summer Jazz Concert Series kicks off at the Walton Arts Center on July 16.
Desserts and Dessert Wines
What's more American than apple pie? Maybe something is, but to celebrate the Fourth of July holiday, let's talk about the perfect wine pairings for apple pies, apple tarts, chocolate desserts and more.
Big Robots Doing Stuff
I like to think the "Transformers" trilogy exists for the sole purpose of landing the underappreciated Turturro a huge payday. In a strange way helps me sleep a little better at night.
'ZGB" Extra With Jim Goza
Need more "Zombie Go Boom" action? Here's a supplemental Q&A with "ZGB" host Jim Goza to go with the feature on undead butt kickin'


Available as low as $3.71 per oz over spot!
During the first two decades of the 20th century, the United States Mint embarked on a mission to revamp and redesign all of its circulation currency. The drive started in 1905 under the guidance of President Theodore Roosevelt, and reached its zenith in the 1910s with the release of new designs for the half-dollar, quarter, and dime. Today, the 90% Silver Mercury Dime is available to you online at Silver.com in a $5 roll.
Ships to you in a plastic tube containing 50 dimes!
Consists of 90% fine silver content per coin.
Individual face values of $.10 (USD) fully backed by the US government.
The original Mercury Dime was in circulation from 1916 to 1945. It was replaced as the design of the dime quickly following the death in office of President Franklin D. Roosevelt. The dime was chosen by the federal government, Secretary of the Treasury, and US Mint because of President Roosevelt's prominent March of Dimes program.
Weinman's original design featured a left-profile portrait of Liberty wearing the Phrygian cap on the obverse side of the coin. The word "Liberty" was engraved above her head, with "In God We Trust" and the year of issue featured below.
Your purchase of this product today includes a total of 50 US Mercury Dimes from the circulation period of 1916 to 1945. The coins arrive in a plastic tube with a total face value of $5 (USD) backed by the US government.
Mercury Dime coins were originally produced at the Denver Mint, San Francisco Mint, or Philadelphia Mint. Only the Denver and West Point Mint coins had mint marks, and each individual dime contains .07234 Troy oz of silver content. In 2016, the US Mint revived the Mercury Dime in the Gold Centennial Series, a collection of 24-karat gold coins marking the 100th anniversary of the Mercury Dime, Walking Liberty Half Dollar, and Standing Liberty quarter.
Please direct your questions to a Silver.com associate at 888-989-7223, connect with us online using our live chat, or email us directly. You can shop for more junk silver on our website!


With this towel you can not only dry off after a shower or beach day, but you can show off your custom design. The PVA towel offers a breathable, mesh feel and absorbs liquids with ease.
Made of PVA with a mesh feel for softness. Quick-absorbing material dries fast.
Customizable to display personal or professional graphics.
Comes in a plastic case with a carabiner top.


text:
@class TWGradientView;

@interface TCGradientViewDemoViewController : UIViewController {

	TWGradientView *gradientView;
}

+ (NSString *)title;

- (void)changeColor:(id)sender;

@end

redpajama_set_name: RedPajamaGithub


text:
Home /Actor Nikkita Ghag flaunts an orange bikini, says "Colors are not associated with any religion."
EntertainmentJanuary 12, 2023
Actor Nikkita Ghag flaunts an orange bikini, says "Colors are not associated with any religion."
Mumbai (Maharashtra) [India], January 12: Pathaan, starring Deepika Padukone, has sparked a major controversy ever since the release of its first song Besharam Rang. Several political individuals have opposed Deepika Padukone's "saffron" bikini. Actress Nikkita Ghag has come out in support of Deepika. According to her, what women wear is their choice. In a song or movie, costumes are selected as per what looks good in a situation; giving it a religious angle shows the ill intention of those who speak, and it's clear that they just want to create division based on religion. They are acting as if no male-female wears innerwear of any colour that is associated with the different regions.
According to Nikkita, Color has no religion. Sure it has significance in every religion, albeit it depends on where and when it has been used and applied. For example, in Hinduism, Orange signifies sacrifice. It's a sacred and auspicious colour. However, if you want to look for other major uses of the colour, then it has also been used as the Symbol of Swaraj flying over Raigad. There it signifies something else, but that does not mean using it in a bikini or as a tablecloth in someone's home it does not mean the significance of the colour has been demeaned. You can't ask people to undress just because they are wearing a particular colour.
Also, for example, Red signifies danger. In Hinduism, the colour has major significance, like the bindi or sindoor but has ceremonial uses, like the Red Carpet. Someone might take objection to using red on a carpet to walk all over it, and it might hurt religious sentiment. Are we going to adhere to every whim and fancy of a section of people and change or adapt just for their sake? Respecting the colour, in particular, makes sense only when it is used in conjunction with religious or other symbols. Not in itself. In Hinduism, we believe in Vasudeva Kutumbakam. The whole world is one family. So who uses what colour for what reason? If we decide to move forward from Religion, colour or caste-based disagreements and just accept the basic concept of Humanity, then things would probably change for the better. And instead of focusing on Deepika's bikini, let's all direct focus on working on managing major issues like Hunger, Rape and many more important issues.
On a creative note, Nikkita looked nothing less than a seductress in the orange bikini. She is seen on a beach amidst sand flaunting the ensemble and posing for cameras. Here's a glimpse of her video: https://www.instagram.com/reel/CnBD4tkBlzX/
Nikkita Ghag is an actress and animal activist who founded Dawa to raise her voice against animal cruelty and inspire women. She was recently honoured with the Pride of India award at the International Film Festival Organization of India's award ceremony in Mumbai, and she has also received the Dadasaheb Phalke Award for this noble cause. Furthermore, on Diwali, Raj Jagatsinh of Youth The Nation Foundation in Rajkot, Gujarat, started a unique initiative of distributing sweets to slum children, of which Nikkita was also a part, and Nikkita received an award for this noble work. Diwali, Raj Jagatsinh of Youth The Nation Foundation in Rajkot, Gujarat, started a unique initiative of distributing sweets to slum children, of which Nikkita was also a part, and Nikkita received an award for this noble work.
The post Actor Nikkita Ghag flaunts an orange bikini, says "Colors are not associated with any religion." appeared first on City Lights.
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florida va loan requirements on Edtech Startup Bodhi AI raises $200K for connecting students to teachers over a 1-to-1 Video call
professional hackers for hire on Rus Education: Reforming Landscape of Overseas Medical Education For Aspiring Doctors in India
stooneene on CEO's Summit 2023 by Indian Plumbing Association provides impetus for future strategy discussions among stakeholders in the building industry
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Elke on IB topper and Northwestern University alumnus starts CRACK IB – live online tutoring with IB Examiners from around the world


1. CSSU Features Configuration - The CSSU Features Configuration application is a user interface to the configuration of several parameters enabled by the Community SSU updates. It provides the ability to change a number of parameters in the transitions.ini configuration file.


Implement strong internal controls to make sure HIPAA is being followed.
2 What Do Supervisors Need to Know About HIPAA & Cobra?
Clear, well-developed policies and procedures are vital to make sure provisions in the Health Insurance Portability and Accountability Act are being followed by your business. HIPAA security and privacy regulations apply to both employees and customers or clients regardless of whether your business works with information covered under HIPAA laws directly or via third-party outsourcing. There's much you can do to ensure HIPAA compliance is consistent and complete.
Create standard operating procedures for business processes that require dealing with HIPAA information. Make SOPs even more helpful and clear by including not only how-to instructions for completing a task, but also an overview that identifies the procedure as being related to HIPAA regulations. For example, SOPs for office personnel can include instructions for getting written authorization before disclosing private medical information either by mail or electronically, storing employees medical and personnel information in separate locations, instructions for communicating a business policy requiring employees to deal directly with the insurance company during initial or open enrollment and for reminding insurers to remove any information that might personally identify an employee on informational claim reports.
A HIPAA-specific confidentiality agreement is vital to making sure employees understand what HIPAA information privacy regulations entail. Require employees to sign and date the agreement, distribute a copy of the signed agreement to each employee and keep a copy in each employee's file. The agreement should describe what constitutes protected health information, describe constraints to sharing private information and outline steps employees must agree take to safeguard private information. For example, directives can require employees to avoid accessing or viewing private unless they have a definite need to know, double-check contact information before mailing or sending information electronically and agree to respect the privacy rights of employees and clients or customers.
Strong internal controls can prevent unintentional or intentional breaches in security. Keep paper documents and computer printouts in closed, locked files. Provide paper shredders and require employees to properly dispose of hard copies no longer needed. Restrict access to hard copy and computer files to only those employees with a need to know. To secure electronic information, maintain a secure computer password policy and instruct employees to safeguard computer screens and lock computers before leaving their workstation.
HIPAA compliance regulations extend to third parties that you do business with. This applies to outsourcing or contracting with a third party to administer a health insurance plan or conduct an employee wellness program. Make sure HIPAA is being followed by requiring the service provider to sign a mandatory business associate contract. Clauses in the contract must explicitly describe the services the third party will provide, including a clause explicitly requiring the business to adhere to HIPAA privacy and security regulations.
Lohrey, Jackie. "Things to Do to Make Sure HIPAA Is Being Followed." Small Business - Chron.com, http://smallbusiness.chron.com/things-make-sure-hipaa-being-followed-78298.html. Accessed 25 April 2019.


text:
// Template Source: BaseEntityRequestBuilder.java.tt
// ------------------------------------------------------------------------------
// Copyright (c) Microsoft Corporation.  All Rights Reserved.  Licensed under the MIT License.  See License in the project root for license information.
// ------------------------------------------------------------------------------

package com.microsoft.graph.requests;

import com.microsoft.graph.http.IRequestBuilder;
import com.microsoft.graph.core.ClientException;
import com.microsoft.graph.models.DriveItemVersion;
import java.util.Arrays;
import java.util.EnumSet;
import javax.annotation.Nullable;
import javax.annotation.Nonnull;
import com.microsoft.graph.core.IBaseClient;
import com.microsoft.graph.http.BaseRequestBuilder;

// **NOTE** This file was generated by a tool and any changes will be overwritten.

/**
 * The class for the Drive Item Version Request Builder.
 */
public class DriveItemVersionRequestBuilder extends BaseRequestBuilder<DriveItemVersion> {

    /**
     * The request builder for the DriveItemVersion
     *
     * @param requestUrl     the request URL
     * @param client         the service client
     * @param requestOptions the options for this request
     */
    public DriveItemVersionRequestBuilder(@Nonnull final String requestUrl, @Nonnull final IBaseClient<?> client, @Nullable final java.util.List<? extends com.microsoft.graph.options.Option> requestOptions) {
        super(requestUrl, client, requestOptions);
    }

    /**
     * Creates the request
     *
     * @param requestOptions the options for this request
     * @return the DriveItemVersionRequest instance
     */
    @Nonnull
    public DriveItemVersionRequest buildRequest(@Nullable final com.microsoft.graph.options.Option... requestOptions) {
        return buildRequest(getOptions(requestOptions));
    }

    /**
     * Creates the request with specific requestOptions instead of the existing requestOptions
     *
     * @param requestOptions the options for this request
     * @return the DriveItemVersionRequest instance
     */
    @Nonnull
    public DriveItemVersionRequest buildRequest(@Nonnull final java.util.List<? extends com.microsoft.graph.options.Option> requestOptions) {
        return new com.microsoft.graph.requests.DriveItemVersionRequest(getRequestUrl(), getClient(), requestOptions);
    }

    /**
     * Gets the request builder for content
     *
     * @return the DriveItemVersionContentStreamRequestBuilder instance
     */
    @Nonnull
    public DriveItemVersionContentStreamRequestBuilder content() {
        return new DriveItemVersionContentStreamRequestBuilder(getRequestUrlWithAdditionalSegment("content"), getClient(), null);
    }

    /**
     * Gets a builder to execute the method
     * @return the request builder
     */
    @Nonnull
    public DriveItemVersionRestoreVersionRequestBuilder restoreVersion() {
        return new DriveItemVersionRestoreVersionRequestBuilder(getRequestUrlWithAdditionalSegment("microsoft.graph.restoreVersion"), getClient(), null);
    }
}


ALA Granite Girls State The 75th session of ALA Granite Girls State, sponsored by the American Legion Auxiliary Department of NH will be held at Franklin Pierce University in Rindge, NH the week of June 23rd to June 29th, 2019. The program focuses on teaching girls the duties, privileges, rights, and responsibilities of good citizenship. The event is open to girls who are completing their junior year of high school. Home schooled students are also eligible. If you are interested, please see the counseling office for more information.
Hugh O'Brian Youth Leadership: The Hugh O'Brian Youth Leadership of New Hampshire (HOBY NH) is looking for high school sophomores for a 3-day leadership seminar that teaches students about individual, group, and societal leadership. The seminar will take place on May 31-June 2, 2019 at St. Anselm College in Manchester, NH. If you are interested, please see the counseling office for more information.
Employment Opportunity: Clark's Trading Post in Lincoln NH will be holding a job fair on Saturday, April 27th from 9:30-1 pm at the Clark's Trading Post Railroad Station. Many positions are available.
Employment Opportunity: Whitefield Recreation is seeking reliable and responsible individuals to help with their After School Activities Program. The program runs 3:00-5:30 Monday-Friday with the exception of school cancellations, early release and vacations. For more information please contact Melissa 603-616-6012.
Help Wanted- Tri-County Cap/Whitefield Senior Meals of Coos County is seeking an enthusiastic, friendly individual for part-time kitchen work this summer. No evenings or weekends! E-mail resumes to hwill@tccap.org or call Herb at 837-2424 for more information.
Late Bus: "Beginning on Monday, April 8, the late bus will be departing WMRHS at 5:15 to bring students back to Whitefield and Lancaster. The bus will continue to run Monday through Thursday."
HELP SHAWNA FIGHT CANCER Shawna Potter, one of our own WMRHS graduates, is fighting ovarian cancer. To help her with her daily monetary needs, we are selling bracelets for her. There are also a very limited amount of key chains. Both are available for a donation of $5. See Mrs. Scales if you'd like one. Thank you for helping Shawna fight her battle!
Special Note: The cafeteria is missing many, many (30) oval plates. If you have some in your classroom please return them ASAP.
Attention all JUNIORS: Prom is right around the corner and if you are planning on going, dues need to be paid in full. Tickets go on sale on Monday, April 15, $30 for a single ticket or $50 for a couple. Any questions, contact class officers, prom committee members, or class advisors.


text:
19:45:30 Huian ◙ It was quiet. It was quiet and she was alone. Except for the cat lounging around her neck, and purring in her ear. Her hand opened the package, the letter…a locket fell out…she blinked, staring at it, picking it up. It was just a locket. A pretty one, and she set it down, before reading the letter slowly. ◙
20:15:36 [Cyrus'Valen] This is Cyrus's letter to Huian: "I am not sure how much you remember of me, given your lack of recognition that day on the train. But you helped save my life once, and you were very good friends with someone very dear to me, Charlie Gray. Over the last few years of her life, I fell in love Charlie and her with me. But it's neither here nor there, and I wish not to get bogged down in sentimental hogwash when there is a favor I request of you. I realize you owe me nothing, but at the very least, do this for Charlie. By the time you receive this, assuming everything goes to plan, I will be dead. I want you to take the locket enclosed with this and deliver it to Charlie's grave. And tell her that I'm sorry for what I've become, for letting my anger rule me. For disappointing her, and walking away from the Cyrus that she loved. Thank you."
20:31:51 [Xia] There was a crack outside of Huian's front door, followed by the soft sound of shuffling and scuffling and a knock on the door. Xia had never mastered the art of apparating gracefully. Her apparating usually ended with at least a stumble or two, if not her falling flat on her ass. But she kept doing it, mostly in hopes that one day she would get better and wouldn't flail around upon arrival. At least she hadn't been splinched. She waited at the door, looking bright as usual, with rainbow colored hair (yes, rainbow), and a bright blue, flowing tank top over a knee length black skirt. Rainbow tennis shoes and a rainbow waist belt completed the ensemble, as though Xia were the poster child for rainbows and everything they stood for. It wasn't unreasonable to assume that she used color change charms on her belt and sneakers. There was no way someone who had lived as frugally as Xia for the first two years after school had turned into a shoe and belt hoarder (possible, but unlikely). "Huian!"
20:39:13 Huian ◙ She didn't know how to feel about the letter. She reay didn't. Huian read it, red it again, her expression going from confusion, to slowly horrified realizations, to pity and then…nothing, setting it down. Why ask this of her? Just because she had been Charlie's friend? Because she saved him in Hogsmeade? Her hand rubbed her scar absently, and she let out a sigh, before hearing the crack outside her door, and then the knocking. Meiling meowed in complaint as Huian moved to open the door, her hair in a messy braid, laying over one shoulder her tank top bright ombre from blue to green, her shorts and bare feet. "Xia!" This was confusing as a visit. But not unpleasant! Oddly, two people in one day saw her in shorts, and she rubbed her hand on her hip. "Come in!" ◙
20:49:08 [Xia] Xia grinned as Huian answered the door, and she slipped inside as soon as she was invited. "Thanks! I brought you something from one of the Conclave vendors. It's alcohol infused chocolates that do funny things to you for a few minutes!" She grinned as she fished the box from one of two bags she carried with her. "He didn't arrive until today, and he said that the fresher they are the better. So I thought I'd bring them by! I have some for Izzy, too. And Mop. I don't know how much they'll like them. But they're getting them anyway." Always a sudden burst of sunshine when it came to Xia. "How are you?" She asked, finally going quiet and turning to face her friend with a big grin.
21:06:59 Huian ◙ "You didn't have to—" Get her anything. Huian never accepted gifts. Gave them out like nobody's business, but if she didn't have too, she didn't take them. But it was Xia, and Xia was the closest Huian had to a best friend. Well, s far. She knew Xia's best friend was Izzy, Izzy hers (Just make out already, both of you.), Mop's was probably a tie (At the moment) between Gloriana and Noriko (Who seemed to be winning) and…Huian had…Kieran. Who she loved, but sometimes there were things he didn't understand. (Really, she had not one close friend, not like that. It almost made her feel sad, but not for long.) She smiled, widely, and Meiling moved to sniff Xia's foot delicately, before meowing and walking away. "I'm…I'm good." Her leg hurt. That letter made her feel weird. She felt…okay. Just…she looked like she felt. Bothered slightly, but not troubled. ◙
21:12:44 [Xia] A laugh escaped her. "Have to? No. But presents are for good friends! And I like to give them when I can." She studied Huian, considering her reply and the way she looked. "Are you sure?" She asked, one hand coming to rest at her hip as her head tilted to one side, a tuft of red hair drifting over her eyes. She pushed it back, and shifted her weight from foot to foot. "There's been a lot going on. I feel a bit out of the loop."
21:20:27 Huian ◙ Huian had shut the door and gestured t the comfortable looking grey couch… "You can sit if you want…you want something to drink?" She could use another juice box, anyway, walking to the fridge, her scar dark and her tattoos peeking out from her tank top across her shoulders and back. If yes, she'd get her one, if not, Huian would get her own drink…and lean on the white counter… "You know the basics, I'm guessing, eh? Cyrus Valen kidnapped Gloriana. Dropped her in St Mungos. Was captured in the Leaky Cauldron. Used dark magic to restore his arm. Died in custody. If I'm correct, is probably not dead. And Mop might finally have a girlfriend, but he's off doing auror stuff, Izzy is giving me insight to magical theory, and…I'm…" Ding what with her life? Now she looked bothered, before smiling a bit sadly. "I'm just here. Doing my thing." ◙
21:32:13 [Xia] She plopped readily into a seat and settled down comfortably. "Yes please." She said with a grin. "I've been running and doing all day. Barely taken a moment to get a drink or have a seat." She pushed one hand through her hair and exhaled, shifting so she and Huian faced each other comfortably. She took the juice box without hesitation, sipping from it slowly. "Well. That's a lot." She said, when Huian finished filling her in, her eyes a little wide. "I've just been helping Ophelia out and working at Kindlebird's all this time." She said, rubbing the back of her neck and sighing. It felt a little weird to be so out of the loop, but then again she supposed if they really needed her, they would have pulled her in. Not being an auror did mean she technically shouldn't be involved in most of the stuff going on.
21:42:47 Huian ◙ She brought back a glass bottle of iced tea for the other woman, and sat in her seat, pulling her legs up to sit cross legged. "It is a lot. I don't know who Ophelia is though." And while her tone was mild, it really wasn't important that she did know. There were lots of people just…"In any case, we're not in school, so it isn't our business. But it is, so it is. I don't…" She didn't have anything to say. She actually looked uncomfortable in her own home, not knowing what to say. "I think Izzy was looking for you yesterday, but he had a bad day, so I made him flip a table before discussing magical theory with him. I'm sorry."
21:49:53 [Xia] After a moment of consideration and quiet thought, Xia got up and came over to her friend, hugging her. "Are you sure you are okay, Huian?" She brushed aside the comments about Izzy. She could find him and they would catch up and all that, but Huian was her concern right now. The other woman seemed out of sorts and uncomfortable, and that in turn made Xia worried. "What's eating at you?" She asked, eyebrows rising as she bit her bottom lip.
22:00:09 Huian ◙ She blinked when Xia hugged her. Huian just blinked, and relaxed a bit, shaking her head. "I'm processing things. I feel like I have a lot on my plate, and I need to do more, all because of Valen." Her eyes lowered, and she let out a breath. "I keep thinking about Valentine's Day. Just…that day." He had used something very dark to restore something he'd lost. She remembered being covered in blood, smelling burnt flesh, hiding a limp for weeks. "What he did forcibly reminds me. And then I start thinking about…what it could have been, the paths it makes, how magic works and it's just so encompassing, referring to everything but having nothing to…" Her hands rose and fell once. She was looking for answers. Her frustration was stemming from lack of them. "Wo de yisi shi…… Ta ma de, Xia." ◙
22:04:21 [Xia] There was a quiet pause, an uncertainty in what else to say in regards to the situation. She simply hugged Huian again, trying to be reassuring as she did so. She didn't speak for a moment, instead thinking about the things on Huian's mind, what she was looking for and considering. "Pondering questions that may or may not have answers. I can see that being downright upsetting. Takes the comfort away, to be sure." She drew away and peered at Huian for a momnt, listening to her and frowning faintly. "Makes me think you need something a bit stronger than a juice box." This last was said with a slight smile, trying to crack a grin across Huian's face as well.
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Item - The Banner Weekly, v. XII, no. 606, June 23, 1894
The Banner Weekly — v. 12 no. 606
In The Depths (Work, page 1)
Captain Cowl, the White Hood Chief; or, Shadower Jack's Doomed Seven (Work, chapters I-III, pages 1-2)
Chris Crewley's Winning Hand; or, The Rascally Valet's Double Game, A Story of Detective Life in Washington (Work, chapters XXV-XXVII pages 2-3)
Bluffing the Bowery (Work, page 4)
Ballads of History: Napoleon's Tear (1815) (Work, page 5)
Secretary Herbert's Dilemma (Work, page 5)
After Rain (Work, page 5)
The Rancher's Four Millions; or, The San Diego Lawyer's Ruse (Work, chapters X-XII, pages 5-6)
To-Morrow (Work, page 6)
The Gold Witch's Shadower, or, The Lone Mascot of Deadman's Den (Work, chapters XIX-XX, page 6)
The Gold Brick Sharps; or, The Arch Schemer's Jugglery, A Story of the Mystic Brotherhood (Work, chapters XX-XXI, pages 6-7)
Your Songs (Work, page 7)
The King-Pin Sport; or, The Missing Miner's Double Claimants (Work, chapters XXX-XXXII (conclusion), page 7)
The Weed Divine (Work, page 8)
The "Rough Riders" as They Are (Work, page 8)
How John Won His Wife (Work, page 8)
The Stolen Will (Work, page 8)
Beadle and Adams (1872-1898) (New York (N.Y.): No. 98 William Street) -- United States
Also includes: Happy-Go-Lucky Papers (department), Bannerettes (department), Letter-pad Papers (department), Wine of the Wits (department), Correspondents' Column (department), Telephone Echoes (department); plus mission and editorial, publisher's advertisements, and short filler items (including "A Straight Shot", "Their Death Song", and "Judge Jesse's Banner Maxims").


Next week we want to make sure everyone on Grand Street is talking about our campaign for new Democratic leadership. We're having a neighborhood outreach marathon on Wednesday, August 9 from 6pm to 9pm, and we want to meet every single Grand Street Democrat in one night. Will you join us?
We want all our neighbors to know what you know: that this hyper-local campaign for two Democratic District Leaders is our best chance to make local elected officials engage directly with Grand Street constituents on a regular basis. If we win on September 12, you and your neighbors can impact decisions made in City Hall, Albany, and Washington.
But without your help, your neighbors might not even know they have a choice this year. Please volunteer for this one evening – Wednesday, August 9 from 6pm to 9pm – to help the campaign.
Yesterday's news of Sheldon Silver's appellate court reprieve is a tough reminder of Silver's dark legacy in our neighborhood. Consider that the Truman Club — Silver's "base of operations" where he "appears to still be pulling strings" — still controls political endorsements, judgeships, and access to local officials. Or consider that the Truman Club's Democratic District Leaders have never condemned Silver's behavior.
We know that many Democrats on Grand Street are as appalled as we are by Silver's history of corruption as a trusted elected official, and that's why we are more determined than ever to campaign for new Democratic leadership on Grand Street.
Personally, we wish no hardship on Sheldon Silver. We're his neighbors too, and are glad for his family at their good news yesterday. But his legacy haunts Grand Street. It's time to turn the page on Silver and his political allies in the Truman Club.
More than 1,200 Democrats signed petitions over the past four weeks to put two new progressive candidates on the ballot for Democratic District Leaders on the Lower East Side. This represents the first real challenge to former Assembly Speaker Sheldon Silver's political club following his conviction on federal fraud, extortion, and money laundering charges.
Caroline Laskow, a documentary filmmaker and author (she co-wrote The Soup Club Cookbook with three neighbors), has lived in Seward Park Cooperative since 2003 with her husband and two children who attend public school. Lee Berman, a lifelong East River Cooperative resident, has been an active public school parent in the district, serves on the board at East River, and was recently appointed to Community Board 3.
They are challenging the incumbent District Leaders, Karen Blatt and Jacob Goldman, who are the candidates of the Truman Democratic Club, "a longtime base of support for Mr. [Sheldon] Silver" (WSJ, 4/12/16 link). The Daily News says that even after his conviction on federal corruption charges in 2015, "Disgraced former Assemblyman Sheldon Silver appears to still be pulling strings" (link).
Laskow and Berman also lead a full slate of challengers for the Democratic County Committee in Assembly District 65 Part A. Last year the Truman Club's County Committee members were criticized for selecting a candidate to succeed Silver based on that person's long, friendly ties to Silver; when Democratic voters weighed in a few months later, the Truman Club candidate came in fourth in a six-way primary.
After this year's election on September 12, these new County Committee candidates, along with Laskow and Berman, plan to form a new Democratic club called Grand Street Democrats in order to further reduce the influence of Silver's Truman Club on local politics.
This summer, Caroline and Lee want to meet every single voter they can before September 12 — and they'd like to do that with you. Will you sign up below to walk with the candidates through your building for one or two evenings this summer?
Voter turnout in local elections is always very low. Caroline and Lee want to change that by encouraging Democrats one by one that this race is important in many ways.
Please sign up below with three dates when you are available, and the campaign will be in touch to settle on a schedule.
When Councilmember Margaret Chin called on Tommy Loeb last night at the mayor's town hall she called him "The man with the pink sticker." That's because Tommy — a long-time resident of East River Coop — was there at Caroline and Lee's request to ask the Mayor for a traffic agent to be stationed at the intersection of Grand and Clinton to help alleviate the dangerous driving and incessant honking that comes from this access route to the Williamsburg Bridge.
This is what can happen when everyone works together — local elected officials who have already raised the issue with the Department of Transportation, almost 600 local residents who have signed a petition to close the Clinton Street approach to the bridge, and then one local resident to push the issue right to the mayor.
DOT Commissioner Polly Trachtenberg acknowledged there is a broader study underway to examine the entire traffic pattern from the FDR to the Williamsburg Bridge, which is absolutely necessary. But that sort of study and implementation can take years. It's already been years since the traffic on Grand became intolerable. Caroline and Lee thought there was something that could be done right now, and asked Tommy to bring their request to the mayor.
At tonight's District One town hall with Councilmember Margaret Chin and Mayor de Blasio, the Mayor pledged to dispatch a traffic agent to the Clinton-Grand intersection to alleviate the problems of pedestrian safety, congestion, and incessant honking while a Department of Transportation traffic study gets underway on this over-used approach to the Williamsburg Bridge.
Last night's action was prompted by a question at the Town Hall by East River cooperator Tommy Loeb, representing Grand Street Democrats at the town hall. The Mayor, Steve Hellman from NYPD's 7th Precinct, and DOT commissioner Polly Trottenberg all agreed with Tommy's suggestion.
This troubled intersection has been the focus of a local petition that now has almost 600 signatures and a letter from local representatives urging the DOT to study the issue.
The traffic issue at Grand & Clinton — resulting in grid lock all the way east on Grand Street, with cars honking and jockeying for position — has a been a problem for years. In 2012 the street patterns were changed to alleviate congestion on Delancey that had resulted in serious pedestrian accidents. Since then, Grand Street residents have been saying that Clinton Street was never designed to be a major approach to the Williamsburg Bridge, which is what it has become. With Essex Crossing construction, the problem has become more acute and is likely to get worse.
Pressure needs to be maintained on city officials and local representatives to make sure this problem finally gets solved.
Brian Lehrer of WNYC had a segment of his show Tuesday devoted to new candidates for public office … and Caroline was in the audience to tell Brian and his listeners why she's running for Democratic District Leader.
To get Caroline Laskow and Lee Berman elected to Democratic District Leaders in September election, first we need 500 registered Democrats to sign our Designating Petitions. That means we need an active volunteer corps to knock on doors and stand on street corners getting those signatures. This is one of the most important things you can do for the campaign! Please sign up for as many volunteer slots as you can, and encourage your friends to join you.


Brown rice syrup has been on my "to try" list for some time. I have seem it used in many vegan recipes and I love trying out new natural sweeteners. I haven't been able to find some at any health food stores so when Tropical Traditions asked if I would like to review it, I happily said yes!
Brown rice syrup is a natural sweetener it is made by steeping whole brown rice with an enzyme. It is great for cooking and baking. It is also gluten free and easily digestible.
For my first experience tasting brown rice syrup, I was surprised by how thick it is. It is thicker than honey and has a mild sweet taste. I enjoyed it in a cup of tea but I've heard that it is great for baking and is almost caramel like. I have big plans for this bottle!
Have you ever had brown rice syrup?
Do you any favourite ways to use it?
I've never heard of it...it looks just like honey! I'm SO going to have to get some! I'm thrilled you were asked to try it....I would never have come across it if you hadn't!
I've been really curious to try this. I usually use agave or honey because I buy them in bulk from Costco, but brown rice syrup is a lot cheaper than agave at my Whole Foods! I would like to put it in granola bars- I have a recipe that calls for it.
I've heard that brown rice syrup works like a charm in granola bars. I've never tasted it on it's own - I'm so curious! You'll have to concoct something awesome to give me an excuse to buy it.
Interesting! I've never tried sweetening anything with brown rice syrup. I did recently try date sugar though! It was an interesting sweetener!
Just wanted to let you know you won my NutraCleanse Giveaway! Congratulations!!!
I've never heard of brown rice syrup, but I think I may give it a try in granola bars. Thanks for sharing!
I've also used it to make granola bars. It was really good. Reminds me I should do it again soon!
Ive been looking for a different kind of sweetener recently - i must try this!


When you drink alcohol heavily for many weeks or months, then your nervous system adjusts to alcohol effect. When you stop using alcohol, the alcohol level lowers and that raises withdrawal. You might observe some early symptoms such as shaky heads, insomnia, nausea, vomiting, headache, and sweating. After some days of stopping alcohol, you may have a hallucination. You may feel or hear things that are not present there.
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A muscle cramp or muscle spasm is a common problem which you might face anytime. It is normal to face muscle pain when you get indulged in something you have not done for so long such as jogging, your exercise intensity level has suddenly increased, heavy workouts or house work. Anyone can get affected by muscle pain may be a child or an old man.
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You have to take 250 to 350 mg three times per day through orally and also at bedtime in the case of adults. You can have this with a good quantity of water. If you skip the dose take it as soon as you remember or restart the dose from the next day. In the case of overdose, you might observe symptoms such as vision problem, shallow breathing, irregular heartbeat, confusion, and hallucinations etc, so convey your doctor about these symptoms.
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In adults the initial dose to be taken is 50 to 100 mg; it should be taken after an interval of four to six hours through the oral route. For relief from chronic pain in adults, the recommended dose should be 25 mg per day through the oral route. The maximum dose can be increased up to 400 mg once per day or 200 mg twice in a day. Swallow the tablet as a whole with a good quantity of water, do not break or crush the tablet. Do not double up the dose as it may cause serious side effects. If in case the dose is missed, take it as you remember or start the regimen from next day.
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Overuse of Ultram may be fatal to health, it may lead to addiction. Strictly banned for pregnant ladies as there are chances of withdrawal symptoms in newborn. Some people are allergic to Tramadol, avoid in those patients. Tramadol should not be used in patients who are below 18 years. Briefly explain to your doctor if you have symptoms of a migraine headache, epilepsy, asthma, alcoholic addiction, vomiting, muscle spasms, nausea, or depression etc. Alcohol, tranquilizers, narcotic drugs, and sedatives potentiate dizziness.
In medical science, pain is the initial stage of any disease or you can say that pain is a startling and alarming sign of any type of disease in our body. Pain can affect every area of the body like head, stomach, back, muscle, eye, legs, and much more. Pain is classified into two parts- acute pain and chronic pain. Acute pain may last for a short time whether chronic pain may last for a long time.
In spite the sensation of pain, you may also feel the symptoms of fatigue and sleep disturbances in your daily schedule. Pain can occur from the various reasons like jerks, accidents, sprain in muscles, fractures, dislocation of bones, and much more. You can follow the other techniques of pain management like various muscles strengthening exercises and stretching of muscles, physical or occupational therapy, acupuncture or acupressure, chiropractic care, and various types of massages are obtainable to provide relaxation from pain.
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The most recommended dose of generic Carisoprodol is 350mg. You can consume it three times in a day via the oral route. The duration of this medication should be up to two to three weeks. This dose may depend on some parameters like age, medical conditions, and tolerance of an individual person. You should take it as per prescribed by your medical practitioners.
You may feel some undesirable effects after consuming the dose of generic Carisoprodol such as drowsiness, dry mouth, heartburn, angioedema, nausea or vomiting, headache, and irritation.
If you are allergic or hypersensitive to generic Carisoprodol, do not consume it and ask your physician for the substitute before using it. Under medical conditions such as epilepsy, heart disease, liver and kidney disease, do not consume it. In the state of pregnancy and breastfeeding, you should not consume generic Carisoprodol as it may become harmful for the fetus and the infant. You may addict to generic Carisoprodol so take it as per prescribed by the medical practitioner.
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Mild pain is normal but it gives an abnormal sense when becomes unbearable. Pain can occur anywhere in the body part and is of various types that can affect the daily life regimen of an individual. Along with the injury, sense of pain and its intensity sometimes depend on the person's mental and emotional stress due to pain. A person may have mild, moderate or severe pain intensity. Every therapy, whether it is medical, rest or physical exercise takes the time to provide a response. Musculoskeletal pain is the most common pain that generally happens with the overuse of a muscle or a body part. Pain is a consequence of an injury, sprains, dislocations, jerking movements, accidents or any other. Bones, muscles, ligaments, tendons or nerves are the main affecting areas of pain. The sense of pain generally travels from the site of injury to the brain through various nerve signals.
Whenever you want to get relieve from your pain problem, then take Pain-O-Soma remedy for the treatment. Pain-O-Soma is an oral preparation that constitutes Carisoprodol as its major working component. Carisoprodol comes in the category of muscle relaxant medication that is helpful in relieving the agony of muscle contractions or spasm. Pain-O-Soma (Carisoprodol) being a muscle relaxant drug acts by breaking the pain signals travelling from the pain site to the brain via spinal cord through the nerves. Thus, Pain-O-Soma acts indirectly on the brain to relieve pain. The onset of action of Pain-O-Soma is 30minutes while the duration of response is for 4-5 hours.
Pain-O-Soma 500mg is available in oral form. An adult patient when to take Pain-O-Soma 500mg dose, then the patient has to consume the dose for 1-2 times in a day with one dose at bedtime. Duration of treatment with Pain-O-Soma is generally for the 2-3weeks duration. Elderly patients need to take the half dose of an adult patient's dose. The maximum dose that an adult patient can take in a day should not be more than 1400mg. Carisoprodol is converted into Meprobamate, the active metabolite of Carisoprodol that has the traits of anxiolytic and sedative.
With prolonged use of Pain-O-Soma and sudden withdrawal of medication, there are chances of drug abuse and withdrawal symptoms. Thus, the user has to reduce the dose first gradually before he or she needs to stop the medication completely. Use of Pain-O-Soma is unsafe to be consumed during an allergic reaction because of Carisoprodol or any ingredient of Pain-O-Soma. Before taking Pain-O-Soma, make sure that your health condition is fine in respect of heart, liver, kidney, blood pressure or bleeding disorder. A patient can take the medication with water irrespective of food but alcohol consumption should be inhibited while taking Pain-O-Soma. Increase or decrease of the dose is never advised as it can lead to other health problems. Use of Pain-O-Soma in patients may cause some negative effects such as extreme weakness, loss of vision, dizziness, or stomach upset. Pain-O-Soma medication therapy is helpful with rest and some light physical exercise therapy. Pregnancy, breastfeeding, and the age below than 17 years are contradictory states for the use of Pain-O-Soma.
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Ultram 200mg is a great extent utilized medication used to combat moderate to severe pain condition. It is helpful to deal with pain associated with surgery, injury, vascular disorder, inflammation, trauma, laboratory or clinical diagnostics, etc. Ultram contains Generic Tramadol, an outstanding pain reliever that falls under the category of drugs called "Narcotic analgesics" that offers the benefit of fast onset action.
You can come across the sign of pain at any instance or after experiencing any blunt thrust; you may scream out and made you stunned for a moment. The pain shivered you like a thunder shatters you down and makes you motionless, no change of direction, no movement, nothing. Pain is nothing but an annoying feeling that is sent from one site to another and finally affects the whole body. Pain is an unwanted symptom that can be experienced at any point in life and by anybody. On may face pain either due to emotional stress, physical injury or medication condition, disease or disorder.
There are numerous pain killers available in the market to manage pain, but most of these pain killers have a big risk of using them because they develop habituation. Ultram 200mg is an effective pain killer that helps to manage both mild to severe pain without causing any habituation. Use Ultram 200mg to manage various pain conditions.
Generic Tramadol treats both moderate to severe pain by reducing pain in 2 unique ways. First, it inhibits the reuptake of norepinephrine and serotonin in post-neural synapse that finally helps to reduce pain signal. On the other hand, Tramadol it acts on the M-opioid receptor and hence lessens pain intensity.
Ultram 200mg is a solid dosage form that needs to be consumed via the oral route with a full glass of water. The measurement of this drug ought to be taken 2 events in a day after each 4 to 5 hours, with or without food. The recommended dose for adults in a day is 400mg in a divided dose while in the case of elderly patients, its 300mg in a divided dose.
Do not use this drug for a longer period of time, as you may develop habituation towards it. Confirm with your doctor before you stop using this medication.
Intake of Generic Tramadol may lead to cause some undesirable side effects that include dizziness, mild headache, difficulty in urination, confusion, vomiting, constipation, twitching in the muscles, nausea, stomach upset, etc.
Warning and precautions while using Ultram 200mg!!!
Pregnant and breastfeeding women should not consume this medication as it gets mix with the milk and causes severe harm to the developing baby.
Use of this drug is contraindicated in case you are allergic to it or any of its other non-active components.
Ultram is a habit forming medicine, even at the fixed doses. It is always advisable to take it as recommended. Never modify its dose as per your wish.
Do not consume alcohol while using this medication.
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Regardless of the vintage, Fattoria Le Terrazze seems to shine, due in no small part to the Ternis' strict crop selection and low yields, so it should come as no surprise that the 2001 Le Terrazze Rosso Conero is delicious. It reveals an elegant soft perfume, redolent with the scents of cherry, rose and violet. Wedded to the wine's seductive floral components is a sensual, earthy aroma that exudes the essence of spring and captures the fecundity of the awakening land. Furthermore, the 2001 Le Terrazze is rich, warm and velvety in the mouth, and it offers up copious quantities of ripe black cherry and cola that mingle with subtle complex tones. Medium to full-bodied, Le Terrazze's ripe sweet tannins provide structure as well as an appropriate framework to highlight the wine's plush elegance. We suggest that you allow this lovely Rosso Conero at least 15-30 minutes to breathe before serving it at cool room temperature (about 66° F). Due to the Terni's natural methods of production and the nature of the Montepulciano varietal, the Le Terrazze may precipitate a harmless, tasteless sediment.
Rosso Conero is the Adriatic's most illustrious wine and Fattoria Le Terrazze is the region's leading producer, so when the crowds leave the area's pretty beach resorts and the tourists take leave of the countless seafood restaurants that anchor the breathtaking Marchesan coastline, rife with cliffs that plummet hundreds of feet straight into the gleaming Adriatic Sea, the local cognescenti put aside the region's Verdicchio and break out the Marches' most serious and compelling red wine - Fattoria Le Terrazze Rosso Conero. A robust, hearty red that possesses both flavor and charm, Rosso Conero is a delicious wine, equally fit for a cold winter night as well as the seductive fecundity of a warm spring evening. It draws its strength and vigor from the flavorful Montepulciano grape, and when blended with up to 15% Sangiovese (the great Tuscan varietal) Rosso Conero combines strength and finesse, resulting in a plush wine of subtle complexity. Antonio and Georgina Terni are the dedicated proprietors of Le Terrazze, where they produce a meager 2000 cases of wine each year from a small, well-situated 15 acre vineyard. Their sole aim is produce the Marches' finest Rosso Conero, a goal many critics and consumers alike believe Antonio and Georgina have already achieved. In order to produce their beautifully wrought wine, they must drop a sizeable portion of each vintage's purple grape clusters onto the meticulously tended vineyard, thereby radically reducing their yield but heightening the flavor and intensity of the resulting wine. Once one of Italy's best-kept secrets, the word is now out; Fattoria Le Terrazze produces compelling Rosso Conero and its wines are becoming increasingly difficult to find. Consider yourself forewarned.


The majority of firms offering unbundled fees find they're helping them to attract more business, according to a Law Times poll.
'Sometimes there's more time spent on it than makes sense,' says Kumail Karimjee.
But the time-consuming nature of the increasingly in-demand work is sometimes proving to be a false economy for lawyers balancing a desire to improve access to justice with the need to run busy practices.
Almost 100 firms took part in the survey and about two-thirds of them offer unbundled fees, also known as limited-scope retainers, that allow clients to take on some of the work themselves. The biggest proportion (45 per cent) of those offering unbundling have done so for between two and five years, although 37 per cent have done it for more than five years and 18 per cent for less than a year.
More than half (55 per cent) of those offering unbundled services say it has helped them to attract more business.
But a quarter of respondents said unbundling hadn't helped to attract more business at all and a fifth didn't know whether it had or not.
Almost half of respondents work in litigation and more than a third in family law, followed by trusts and estates, corporate/commercial, real estate, and alternative dispute resolution. The majority are sole practitioners or at firms with between two and 10 lawyers.
Demand for unbundling has grown along with the increase in self-represented litigants. But while it may be attracting new clients, this isn't necessarily translating into increased revenues.
His firm usually offers unbundled services to people of limited financial means but also sometimes because clients feel they're better off strategically with a lawyer who stays behind the scenes.
Clients are also increasingly contacting Karimjee halfway through a case that has started to heat up. While picking up a file from a self-represented litigant is "very challenging," being able to offer unbundling at an early stage means a lawyer can advise clients on how to gather evidence and reduces the risk of the case becoming messy and unmanageable, he says.
A number of survey respondents who didn't offer unbundled services cited the risk of additional costs. Others expressed concerns about people without legal training carrying out the work or said their firms' partners weren't eager to change traditional fee structures. The biggest worry, mentioned by one in five respondents whose firms didn't offer unbundling, was the risk of a lawsuit.
The possibility of disputes over the agreed scope of the work sparking malpractice claims is one reason why unbundling "scares" LawPRO, says Dan Pinnington, vice president of claims prevention and stakeholder relations.
Lawyer and client communication issues have represented a third of LawPRO claims and costs over the past decade, an issue that's particularly likely to arise as a result of unbundling, says Pinnington. "I'm pleased to see that people seem to be aware of and appreciate the issues," he says in commenting on the survey results.
In an attempt to minimize the likelihood of claims, the Law Society of Upper Canada issued guidance in 2011 requiring lawyers to provide written confirmation of any limited-scope retainer.
Family lawyer Andrew Feldstein says he's careful to provide retainer agreements setting out the full scope of the work and clearly stating the firm won't be charging a block fee. He reiterates those facts in e-mails and letters. "It's always good to remind the client of the details," he says.
About 10 per cent of Feldstein's practice involves unbundled services but he expects the demand to grow in the future. "It's absolutely an access to justice issue," he says.
Grey areas remain, however. It's not always possible to "draw a box" around a service that lawyers have pledged to provide, says Pinnington.
For example, a lawyer may agree to appear at a preliminary hearing, but it may not be obvious whether it commits them to dealing with questions arising from any order made on that day. Despite the concerns, LawPRO hasn't seen a significant rise in claims related to unbundling.
Pinnington advises lawyers to interview prospective clients as carefully as if they could afford full representation. "Lawyers providing unbundled legal services owe the same duties of competence, diligence, loyalty, and confidentiality to limited-scope clients that they owe to full-service clients," he warns.
Our profession lacks imagination and creativity - and this has greatly contributed to the access to justice issue, and is apparent in this article.
I have engaged several Judges in discussion who have, unanimously, suggested that if the scope of retainer is clearly limited - they are not likely to look beyond it to find obligations extending beyond the terms of the retainer - because THEY need the assistance of lawyers with Self-Represented litigants as well.
With some vision and re-arrangement of practice models, including clear value-based billing marketing, with a reduction in the paternalistic view of our job as requiring "control" of our clients, and with a vision as to just how massive the potential market is for LSR, the profession could not only greatly improve access, but could do so very profitably.


Yesterday, we reported on the The Bachelor's Degrees With The Highest Salary Potential, but many careers today require a master's degree, particularly for those who wish to advance or earn more money.
Which of those graduate-level degrees are worth the staggering pricetag? As part of their 2016 - 2017 College Salary Report, PayScale combed data for nearly 200 graduate-level degrees and ranked them according to the mid-career salaries of full-time U.S. employees who hold those degrees.
Employees surveyed for this report graduated from schools in the U.S. and are not currently on active military duty. The list does not include MBAs.
At the top of this ranking is Nurse Anesthesia. Careers associated with this degree, described by the Bureau of Labor Statistics as belonging to those who "administer anesthesia, monitor patient's vital signs, and oversee patient recovery from anesthesia" pay early career wages of $140,000 and mid-career wages of $156,000.
Computer Science and Engineering comes in second, with mid-career wages of $134,000. Operations Research and a tie between Electrical and Electronics Engineering and Taxation round out the top five. Each offers mid-career compensation upwards of $129,000.
Further down the list a wealth of engineering-focused degrees–including Chemical Engineering, Biomedical Engineering, and Industrial Engineering– as well as degrees in Applied Mathematics, Finance, and Economics all make the cut with mid-career wages between $115,000 and $121,000.


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text:
Wofford's Hannah Steelman running for a pair of national championships
Todd Shanesy Staff Writer @TerrierTracker
Jun 7, 2019 at 8:45 PM Jun 7, 2019 at 11:19 PM
Hannah Steelman, who approaches long-distance races analytically as much as athletically, was concerned about coming from behind in her 3,000-meter steeplechase preliminary qualifier for the NCAA championship.
So she just stayed in front.
Well, now, that didn't take too much logical thought.
The Wofford sophomore won her heat Thursday and finished with the third-fastest overall time among 24 competitors in Austin, Texas. She will be in the final scheduled for 6:54 p.m. Eastern (ESPN2) as well as the 5,000-meter event at 8:25 p.m. Steelman had already qualified for the latter because there are no preliminaries, so her focus this week has been more on the 3,000 with its hurdles and splash-filled landings.
"Honestly, I trust my ability to stay in the lead more than I trust my kick," she said. "Those girls have really quick finishes. I didn't want to put myself in a position where I got outsprinted at the end and didn't qualify."
Steelman (Orono, Maine) led nearly her entire heat, briefly falling behind Brianna Ilarda of Providence, who faded and had the 12th–best overall. The No. 1 was Allie Ostrander of Boise State, five seconds better than Steelman, who set a school record and already owned the Southern Conference record.
"This is what I've been focusing on all year, steeplechase at nationals," Steelman said. "I'm very excited to have made the final, but that was just part of the plan. I can't act like winning a heat in the prelims is like winning a national championship.
"The PR (personal record) makes me feel good. I don't think that's the fastest I can go. I still feel like there's more in me. That's kind of exciting."
Steelman last year became the first Wofford track and field athlete to qualify for the national championships. And she never felt more like a freshman.
"I had never experienced the amount of nerves on a starting line as I did last year at nationals," she said. "You walk out and you see the crowd. The bleachers are full, something we don't often experience in the track and field world. I think I let the large-scale competition get to me. It was super-intimidating. I think I had it in my head that all these girls were better than me. I was just there for the experience. I don't think I took it as seriously as I should've."
She didn't make it to the finals.
"I don't see last year as anything I dwell on," she said. "But it does motivate me to try to be more confident and prove to myself and others that I do belong here."
Wofford head coach Johnny Bomar said he believes Steelman can win a national championship, even as a sophomore.
"She's ready," said Bomar, an Inman native and former multi-sport talent at Chapman High School. "She's worked really hard and I think this is as good as she's felt. She wants to be great. That's the main thing. I think she will do really well."
There won't be much time between races, the 3,000 and the 5,000, only about an hour. Steelman said she likes that the 3,000 will be first but would've planned to go just as hard if the situation had been reversed.
"They are both national championship races. You can't tell yourself you'll go harder in one," Steelman said. "The 5K is not really on my mind right now only because I'm focusing on what's next and that is the steeplechase. It will be a quick turnaround, but I'm just hoping that the steeple goes well and my adrenaline will get me through the 5K."


Kyle Busch was fastest in first practice followed by Denny Hamlin, last weekends winner Paul Menard, Joey Logano, Ty Dillon.
Joey Logano paced Final Practice with First Practice Winner Kyle Busch closely behind in 2nd. Ty Dillon, Kyle Larson, and Daniel Suarez rounded out the Top 5!


VE3WDM's Elecraft k2 build: A way to mount control knobs right the first time!
A way to mount control knobs right the first time!
The front panel is now complete I mounted the VFO without any problems...but...On page 32 you are asked to secure the front plate and PC board (via a standoff) with a 4-40x 3/16 flat head screw. According to the front plate you will see this screw should be beveled. I used the 4-40 82 degree flat head screw here. Once the front plate and front panel are together the radio starts to take some shape. It's now time to add the control knobs and I am a fuss pot and want the knobs to be the same height off the front panel plate. I have found a sure way of doing this and it adds a nice finish to the radio when all the knobs are placed the same distance off the front plate. Here is how I do it and it's simple, cheap and works every time!
1. Set the pots to either fully clockwise or counter clockwise, on some pots one position is better than the other for tightening the set screws. Test it out and see, also I know the manual says mid position all pots but I have found this is not great for securing the set screws with the Allen key.
2. Place the washer around the "Keyer" pot.
3. Now put the plastic keyer knob on (with set screws loosened) until it rests against the washer.
5. Tighten up both set screws on the keyer knob and then remove the washer.
Note: Put the knobs on in the following order Keyer, Power, AF gain and RF gain. If not you may run into trouble removing the washer.
6. Now do the same to the RIT plastic control knob.
The VFO knob is not to be installed this way as it has a felt washer put between the VFO knob and front plate. This is to allow the user to adjust the VFO knob resistance, by moving the VFO knob closer or further away from the felt washer.