text:
Home Books Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e
Chapter 7: Pharmacogenetics
Dan M. Roden
Roden DM. Roden D.M. Roden, Dan M.Pharmacogenetics. In: Brunton LL, Hilal-Dandan R, Knollmann BC. Brunton L.L., & Hilal-Dandan R, & Knollmann B.C.(Eds.),Eds. Laurence L. Brunton, et al.eds. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e. McGraw Hill; 2017. Accessed January 27, 2023. https://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=2189&sectionid=167889559
Roden DM. Roden D.M. Roden, Dan M. (2017). Pharmacogenetics. Brunton LL, Hilal-Dandan R, Knollmann BC. Brunton L.L., & Hilal-Dandan R, & Knollmann B.C.(Eds.),Eds. Laurence L. Brunton, et al. Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e. McGraw Hill. https://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=2189&sectionid=167889559
Roden DM. Roden D.M. Roden, Dan M. "Pharmacogenetics." Goodman & Gilman's: The Pharmacological Basis of Therapeutics, 13e Brunton LL, Hilal-Dandan R, Knollmann BC. Brunton L.L., & Hilal-Dandan R, & Knollmann B.C.(Eds.),Eds. Laurence L. Brunton, et al. McGraw Hill, 2017, https://accessbiomedicalscience.mhmedical.com/content.aspx?bookid=2189&sectionid=167889559.
IMPORTANCE OF PHARMACOGENETICS TO VARIABILITY IN DRUG RESPONSE
PRINCIPLES OF PHARMACOGENETICS
PHARMACOGENETIC STUDY DESIGN CONSIDERATIONS
PHARMACOGENETICS IN CLINICAL PRACTICE
It is a given that patients vary in their responses to drug therapy. Some patients derive striking and sustained benefits from drug administration; others may display no benefit, and still others display mild, severe, or even fatal adverse drug reactions (ADRs). Common sources of such variability include noncompliance, medication errors, drug interactions (see Chapter 4 and Appendix I), and genetic factors. Pharmacogenetics is the study of the genetic basis for variation in drug response and often implies large effects of a small number of DNA variants. Pharmacogenomics, on the other hand, studies larger numbers of variants, in an individual or across a population, to explain the genetic component of variable drug responses. Discovering which variants or combinations of variants have functional consequences for drug effects, validating those discoveries, and ultimately applying them to patient care and to drug discovery are the tasks of modern pharmacogenetics and pharmacogenomics.
ABCB1: multidrug resistance transporter (P-glycoprotein)
ACE: angiotensin-converting enzyme
ADR: adverse drug reaction
AUC: area under the curve
CBS: cystathionine β-synthase
CF: cystic fibrosis
CNV: copy number variation
cSNP: coding SNP
CYP: cytochrome P450
EGFR: epidermal growth factor receptor
EMR: electronic medical record
FDA: U.S. Food and Drug Administration
FH: familial hypercholesterolemia
GI: gastrointestinal
G6PD: glucose-6-phosphate dehydrogenase
GST: glutathione-S-transferase
GSTM1: glutathione-S-transferase M1
GWAS: genome-wide association study
HIV: human immunodeficiency virus
HMG-CoA: 3-hydroxy-3-methylglutaryl coenzyme A
5HT: 5-hydroxytryptamine, serotonin
indels: insertions or deletions
INR: international normalized ratio
iPSC: induced pluripotent stem cell
LDL: low-density lipoprotein
MAF: minor allele frequency
MDR1: multidrug resistance protein 1
mRNA: messenger RNA
MTHFR: methylenetetrahydrofolate reductase
nsSNP: nonsynonymous SNP
PharmGKB: Pharmacogenomics Knowledgebase
PheWAS: phenome-wide association study
PM: poor metabolizer
RCT: randomized clinical trial
SNP: single-nucleotide polymorphism
SNV: single-nucleotide variant
sSNP: synonymous or sense SNP
TPMT: thiopurine methyltransferase
TYMS: thymidylate synthase
UDP: uridine diphosphate
UGT: UDP-glucuronosyltransferase
UTR: untranslated region
VKORC1: vitamin K epoxide reductase
An individual's response to a drug depends on the complex interplay among environmental factors (e.g., diet, age, infections, other drugs, exercise level, occupation, exposure to toxins, and tobacco and alcohol use) and genetic factors. Genetic variation may result in altered protein sequence and function or in altered protein levels through regulatory variation. Key genes involved in driving variable drug actions include those encoding drug-metabolizing enzymes, drug transport molecules, the molecular targets with which drugs interact, and a host of other genes that modulate the molecular context within which drugs act, notably genes dysregulated in the disease for which the drug is administered. In some situations, variation in nongermline genomes (e.g., in cancers or in infectious agents) can be critical determinants of variable drug responses.
Drug metabolism is highly heritable, as assessed using drug exposures in monozygotic versus fraternal twins, drug exposures in cell lines from related subjects, or analysis of very large data sets ...


Discuss football, American football, cycling, tennis, golf, or anything sporty!
Poll: Will Tiger catch or surpass Nicklaus' 18 major championship victories?
Who is watching Wrestlemania 35?
Wouldn't have given up a old toilet for Jimmy Butler.
Football team with hottest cheerleaders?
Sports gaming, simulations, what-ifs, etc.
Any thoughts on WWE Evolution?
Baseball is Back! - the 2018 Season.
Anyone watch the AJ Styles vs Samoa Joe match on Summerslam?


text:
Political Gabfest
COVID Tsunami
Play • 1 hr 20 min
As part of our 15th anniversary celebration please share an original political cocktail recipe with us. Visit www.slate.com/cocktail to submit your recipe!
Here are some notes and references from this week's show:
Emily Bazelon for The New York Times Magazine: "The Pandemic Election"
Isaac Chotiner for The New Yorker: "How We Can Contain the Second Wave of the Coronavirus"
Mike Pence for The Wall Street Journal: "There Isn't a Coronavirus 'Second Wave'"
Between the World and Me on HBO
Ta-Nehisi Coates for The Atlantic: "The Case for Reparations"
The Water Dancer by Ta-Nehisi Coates
Josie Duffy Rice for Vanity Fair: "The Abolition Movement"
Barack Obama for The Atlantic: "I'm Not Yet Ready to Abandon the Possibility of America"
Jed Sugerman for The Washington Post: "Trump's Legal Challenges to the Election Will Help Democrats"
Here are this week's cocktail chatters:
Emily: Blood Runs Coal: The Yablonski Murders and the Battle for the United Mine Workers of America by Mark A. Bradley
John: John's fundraising page for Covenant House's Virtual Sleep Out; Charlotte Regan's short documentary, "No Ball Games: Life and Play Through the Eyes of Children Across the UK"
David: Washington Post: "Fort Hood is named for a Confederate traitor. Is it time for 'Fort Benavidez'?"
Listener chatter from Mike @rifenbury: Kanazawa Kenichi video
For this week's Slate Plus bonus segment David and John discuss the holiday movies they'd like to see made.
You can tweet suggestions, links, and questions to @SlateGabfest. Tweet us your cocktail chatter using #cocktailchatter. (Messages may be quoted by name unless the writer stipulates otherwise.)
The email address for the Political Gabfest is gabfest@slate.com. (Email may be quoted by name unless the writer stipulates otherwise.)
Podcast production by Jocelyn Frank.
Research and show notes by Bridgette Dunlap.
Why Is This Happening? with Chris Hayes
Chris Hayes, MSNBC & NBCNews THINK
The Attack on the Capitol with Ta-Nehisi Coates
One day after the attack on the Capitol, Chris Hayes and author Ta-Nehisi Coates sat down to process what we witnessed as a nation and what it reveals about the fragility of American democracy. RELATED READING: Twilight of the Elites: America After Meritocracy by Chris Hayes We Were Eight Years in Power: An American Tragedy by Ta-Nehisi Coates The Water Dancer by Ta-Nehisi Coates
Stay Tuned with Preet
Policing the Capitol (with Scott Thomson & Charles Ramsey)
In this special episode of Stay Tuned, "Policing the Capitol," former New Jersey Attorney General and CAFE Insider co-host Anne Milgram interviews former Camden, NJ Police Chief Scott Thomson and former D.C. Police Chief Charles Ramsey, both of whom have had influential careers in law enforcement and championed blueprints for police reform. They discuss the police response to the attack on the Capitol on January 6th, how to prepare for the worst, and why departments need to address the problem of officers having ties to hate groups. For show notes and a transcript of the episode, head to: https://cafe.com/stay-tuned/policing-the-capitol-with-scott-thomson-charles-ramsey To listen to Stay Tuned bonus content, become a member of CAFE Insider at: CAFE.com/Insider Sign up to receive the CAFE Brief, a weekly newsletter featuring analysis by Elie Honig, and features by CAFE staff: CAFE.com/brief And if you haven't already, sign up to receive a link to this week's election focused episode of CAFE Insider: cafe.com/preet As always, tweet your questions to @PreetBharara with hashtag #askpreet, email us at staytuned@cafe.com, or call 669-247-7338 to leave a voicemail. Stay Tuned with Preet is produced by CAFE Studios. Executive Producer: Tamara Sepper; Senior Editorial Producer: Adam Waller; Technical Director: David Tatasciore; Audio Producer: Nat Weiner; Editorial Producer: Noa Azulai. See omnystudio.com/listener for privacy information.
The Next Four Years: Fighting tech monopolies
Matt is joined by antitrust and competition policy expert Charlotte Slaiman to discuss the ongoing antitrust cases against Google and Facebook, the basics of antitrust litigation, and their outlook for the future of regulatory efforts to rein in the power of Big Tech through pro-competition policy. Resources: "Only Regulation Can Jumpstart Competition in Big Tech" by Gene Kimmelman and Charlotte Slaiman, Fortune (July 16, 2019) "FTC Sues Facebook for Illegal Monopolization" (December 9, 2020) "Colorado Attorney General leads multistate lawsuit seeking to end Google's illegal monopoly in search market" (December 17, 2020) Guest: Charlotte Slaiman (@CharlottesWWWeb), Competition Policy Director, Public Knowledge Host: Matt Yglesias (@mattyglesias), Slowboring.com Credits: Erikk Geannikis, Editor and Producer. The Weeds is a Vox Media Podcast Network production. Want to support The Weeds? Please consider making a contribution to Vox: bit.ly/givepodcasts About Vox Vox is a news network that helps you cut through the noise and understand what's really driving the events in the headlines. Follow Us: Vox.com Facebook group: The Weeds Learn more about your ad choices. Visit megaphone.fm/adchoices
Trumpcast
Slate Podcasts
The Former MAGA Soldier Who Skipped the War
Virginia Heffernan talks to former Trump troll David Weissman about his experiences overcoming trauma as a war veteran, his relationship with white supremacist personality Baked Alaska, the right-wing calls for civil war, the different factions of MAGA, and what's going on in the minds of the insurgents. Learn more about your ad choices. Visit megaphone.fm/adchoices
Pod Save the World
Crooked Media
Samantha Power's point
Tommy and Ben discuss last week's violent coup attempt and the call for new domestic terrorism laws, how world leaders are reacting to Trump's Twitter ban, Netanyahu's announcement of new Israeli settlements and how Biden should handle it, and all the things Mike Pompeo is trying to screw up for the incoming Biden administration. Then former US ambassador to the UN Samantha Power joins to talk about how to restore American credibility at international organizations, Bill Burns as CIA director, last week's mass arrests in Hong Kong and refugee policy. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Trump, Inc.
WNYC Studios
Nobody Wants To Work With The Trumps Anymore
In the wake of the Jan. 6 insurrection at the Capitol and an unprecedented second impeachment, a growing number of businesses, governments, and financial institutions are severing ties with President Trump. David Fahrenthold is a Pulitzer Prize-winning reporter who covers the Trump family and its business interests for The Washington Post. Zach Everson reports on who patronizes the Trump family businesses for the newsletter 1100 Pennsylvania. Next week's Trump, Inc. will be the final episode of the series. Subscribe to our newsletter for updates on what we're doing next. Show your support with a donation to New York Public Radio.
Left, Right & Center
President Trump is the first president to be impeached twice. What does it mean to hold him accountable? And what should be done about the Republicans who voted to throw out the results of the election? Some Republicans are saying impeachment is divisive and the country needs to move on, but what about the lies the party has tolerated and fomented about the election for months and months. Weren't those divisive too? Josh Barro talks with panelists K. Sabeel Rahman and Lanhee Chen and special guest Zeynep Tufekci about the role social media played in spreading conspiracy theories that led to the riot. Do recent actions by Amazon and Facebook and Twitter reduce the risk of future unrest? And should we worry about the role these large private firms play in shaping the rules of our discourse? President-elect Biden is preparing to take office as his predecessor's impeachment trial begins. He wants another $1.9 billion relief package — and bipartisan support for it. Can he get that?
LRC Presents: All the President's Lawyers
One week after a pro-Trump mob stormed the U.S. Capitol, interrupting the congressional proceeding that affirmed Joe Biden's defeat of President Trump, officials from the FBI and the Department of Justice have made some arrests and have promised more are on the way. What are the charges we know about right now, and what do they mean? Are there other possible charges? And is President Trump in legal trouble for his words and conduct in support of the insurrection? Josh Barro and Ken White talk about possible legal problems President Trump could face, and the political consequence: impeachment. As we recorded this episode, the House was moving closer to a vote on one article of impeachment (that has since passed). What are the other political remedies for President Trump besides impeachment? Can a twice-impeached president still exercise his pardon power, have Secret Service protection, and run for office again?
The New Abnormal with Molly Jong-Fast & Rick Wilson
MAGA Riot's Chilling Reality: Regular Folks, Ready to Kill
One of the most frightening aspects of the assault on the U.S. Capitol was how, well, normal some of the participants seemed—and how openly they spoke of their willingness to murder other Americans if President-elect Joe Biden's electoral victory was certified. The Daily Beast's Will Sommer was outside the Capitol on Jan. 6 and described his conversations with the rioters to co-hosts Rick Wilson and Molly Jong-Fast on the latest episode of The New Abnormal. "I was really struck by the people I talked to who were not necessarily crazed QAnon people... but kinda just like people you might think of as your neighbors, your grandparents," Sommer said. "And just almost to, to a person, they were all just like, 'Well, if Joe Biden gets his votes certified today, there's going to be violence and we're going to kill people, and there's gonna be a civil war. Then, Rep. Eric Swalwell (D-CA) joined Wilson and Jong-Fast to talk about what happened after he was told to "take out a gas mask and get ready to duck" inside the Capitol. For a while, Swalwell said, the reality of the danger just was not sinking in. "I still thought, there's no way they're coming in here—until the house chaplain went up to the podium where the president usually speaks for the State of the Union," he said. "And she started offering a prayer and I thought, OK, they're going to get in here. This is not good." Sommer said he was struck by the "huge amount of entitlement" among the MAGA rioters. "I do feel like so much of the reaction, both from the rioters and the people who were there at the protest in general, was this shock that laws would apply to them," he said. "...A weird thing I heard a lot at the Capitol was this idea that if you pay taxes, you could just break into whatever federal building you feel like. And because your taxes in an indirect way pay for the Capitol Police that... you're their boss." When the conversation shifted to President Donald Trump's impeachment in the House, Wilson said more Republicans would have voted to impeach if the vote hadn't been public. "One of the guys that voted in favor of impeachment told me… if it was a secret ballot, Trump would have been impeached with 50 percent or more of the caucus voting against him." "They're fucking petrified," Wilson said. "Well, guess what? You created this monster and you kept feeding it. You kept it in the basement. You hauled it out to vote every two years, but you kept feeding it and now it's loose and it hates you more than it hates anything. I say this a lot: There's nothing a Trump voter hates more than a Republican that doesn't support Trump." Want more? Become a Beast Inside member to enjoy a limited-run series of bonus interviews from The New Abnormal. Guests include Cory Booker, Jim Acosta, and more. Head to newabnormal.thedailybeast.com to join now. See acast.com/privacy for privacy and opt-out information.
The Al Franken Podcast
District Productive
Rick Wilson, Co-Founder of The Lincoln Project
A wide-ranging conversation and Al's opening monologue on this week's events
The Lincoln Project
Trump vs Democracy Revisited: Anne Applebaum on Authoritarianism
After the violent mob attacked the U.S. Capitol at the direction of the president last week, we decided to resurface a conversation from August between host Ron Steslow and Anne Applebaum about her book, Twilight of Democracy, and the warning signs of authoritarianism we were witnessing.
FiveThirtyEight Politics
FiveThirtyEight, 538, ABC News, Nate Silver
On Wednesday, the U.S. House of Representatives voted 232-197 to impeach President Trump a second time. In this installment of the podcast, HuffPost's polling editor, Ariel Edwards-Levy, joined Galen and Perry to discuss why the vote broke down the way it did, what the different camps within the GOP are and what happens next.
You Missed a Spot
Evidence shows that insurrectionists used the walkie-talkie app Zello to help organize the riot at the capitol. On this week's On the Media, a look at how the platform has resisted oversight, despite warnings that it was enabling right-wing extremism. Plus, how to sniff out the real corporate boycotts from the PR facades. And, how to build social media that doesn't exploit users for profit. 1. OTM reporter Micah Loewinger [@MicahLoewinger] on Zello's role in last week's insurrection, and what the app is finally doing about its militia members. Listen. 2. Casey Newton [@CaseyNewton], writer for Platformer, on why this wave of social media scrubbing might not be such a bad thing. Listen. 3. Siva Vaidhyanathan [@sivavaid], professor of media studies at the University of Virginia, and Americus Reed II [@amreed2], professor of marketing at the Wharton School of Business, on the true costs of corporate boycotts. Listen. 4. Eli Pariser [@elipariser], co-director of Civic Signals, on how to build digital spaces that do not monetize our social activity or spy on us for profit. Listen. Music from the show: Fallen Leaves — Marcos Ciscar The Hammer of Loss — John Zorn — A Vision in Blakelight Hard Times — Nashville Sessions — Songs of the Civil War What's that Sound? — Michael Andrews In the Bath — Randy Newman Boy Moves the Sun — Michael Andrews Ain't Misbehavin' — Hank Jones
Origins of a 6' 9" Candidate
On the Gist, the QAnon Shaman's lawyer. In the interview, John Fetterman, also known as Lieutenant Governor Stone Cold, talks to Mike about his potential Senate run. The Pennsylvania native talks about his origin story from son of teenagers to Harvard graduate, his thoughts on gun control and incarceration, and the woes of being six-foot-nine. (Not enough suits.) In Remembrances of Things Trump: so many Seans, so little time. In the spiel, supposed contradictions of pro-free speech. Email us at thegist@slate.com Podcast production by Margaret Kelley, Cheyna Roth, and Jasmine Ellis. Slate Plus members get bonus segments and ad-free podcast feeds. Sign up now. Learn more about your ad choices. Visit megaphone.fm/adchoices
Hacks on Tap with David Axelrod and Mike Murphy
2020: Extra Innings (with John Heilemann)
Axe and Murphy sit down with the one and only John Heilemann to try to make sense of this moment. The Hacks discuss some of the dynamics that contributed to the insurrection, the politics of a second impeachment trial, and Trump's unwillingness to accept any responsibility for the mob he helped incite. But, it's not all doom and gloom: The Hacks also discuss the rounding out of Biden's cabinet, including the one and only Gov. Gina Raimondo. Learn more about your ad choices. Visit podcastchoices.com/adchoices
Amicus With Dahlia Lithwick | Law, justice, and the courts
The Domestic Terror Arm of MAGA
Dahlia Lithwick is joined by Juliette Kayyem, former assistant secretary at the Department of Homeland Security under President Barack Obama, currently serving as the faculty chair of the homeland security program at Harvard's Kennedy School of Government, to look at the violent extremist elements of the MAGA movement and how counterterrorism tools can inform the response to the attack on the Capitol and President Trump's "stochastic terrorism." In our Slate Plus segment, Mark Joseph Stern joins Dahlia to discuss developments in the judiciary in North Carolina and Pennsylvania, the high court's decision to greenlight more federal executions in the last days of the Trump administration, and the first abortion case of the Amy Coney Barrett era. Sign up for Slate Plus now to listen and support our show. Podcast production by Sara Burningham. Learn more about your ad choices. Visit megaphone.fm/adchoices
Vox Conversations
Sam Sanders and Olivia Nuzzi on President Trump's last days
New York magazine's Washington correspondent Olivia Nuzzi spent the past four years covering the Trump White House. In this inaugural episode of Vox Conversations, Nuzzi talks to guest host Sam Sanders, host of NPR's It's Been a Minute, about the perils of anonymous sourcing, some unexpected job hazards (self-loathing), and why Trump didn't ultimately create, but instead activated, the crowd of insurgents that breached the Capitol last week. Learn more about your ad choices. Visit megaphone.fm/adchoices
What Next | Daily News and Analysis
TBD | Where the Far Right Is Meeting Now
After Facebook and Twitter banned thousands of accounts in the wake of the Capitol riots, fringe groups are flocking to platforms like Signal and Telegram. With the inauguration just days away, and government officials warning of violence, QAnon believers and Stop the Steal protesters are now communicating in encrypted spaces. What, if anything, is being planned? Guest: Will Sommer, politics reporter at the Daily Beast Host Lizzie O'Leary Learn more about your ad choices. Visit megaphone.fm/adchoices
Lovett or Leave It
Good Riddance (Crime of Your Life)
Wednesday is the day Trump finally becomes not president. Kara Swisher joins to talk about social media companies facing hate and incitement on their platforms and what a Democratic Congress can do (and Kara learns some breaking Ivanka/Jared news on the spot). Then Lovett quizzes Favreau and Tommy on four years of scandal and their awesome tweets. And we're back on omegle to tell listeners jokes at random and it went pretty well! Learn more about your ad choices. Visit podcastchoices.com/adchoices
Michael Isikoff & Daniel Klaidman
The Ordeal of Jamie Raskin
Jamie Raskin, U.S. Representative from Maryland, joins Michael Isikoff and Daniel Klaidman on "Skullduggery." On New Year's Eve, Raskin learned that his son had taken his own life. While grieving, Raskin, a constitutional law professor and member of the House Judiciary Committee, was determined to do his duty to uphold American democracy. He helped draft two resolutions that passed the House this past week. One to invoke the 25th Amendment. And the other, to impeach President Trump for violating his oath of office. See acast.com/privacy for privacy and opt-out information.
More episodes from Political Gabfest
The Greatest Betrayal
Emily, David and John talk about impeachment, whether Americans can be deradicalized, and guest Juliette Kayyem joins in to discuss vaccine distribution. Here are some notes and references from this week's show: Emily Bazelon for the New York Times Magazine: "People Are Dying. Whom Do We Save First With the Vaccine? Identity Crisis: The 2016 Presidential Campaign and the Battle for the Meaning of America by John Sides, Michael Tesler, and Lynn Vavrek Amarnath Amarasingam's Twitter thread on de-platforming extremists. Amarnath Amarasingam, Shiraz Maher, and Charlie Winter for the Centre for Research and Evidence on Security Threats: "How Telegram Disruption Impacts Jihadist Platform Migration" The music of Ludovico Einaudi The music of Joan Armatrading The music of John Prine The music of M.I.A. The music of Joan Jett The music of Maren Morris The music of Joni Mitchell The music of Bob Mould and Husker Du The music of Nick Thompson Nicholas Thompson for Wired: "To Run My Best Marathon at Age 44, I Had to Outrun My Past" "Iko Iko" performed by the Grateful Dead "You'll Never Walk Alone" performed by Gerry and the Pacemakers Tusk by Fleetwood Mac Desire by Bob Dylan In Search of Lost Time by Marcel Proust Here are this week's cocktail chatters: John: Nathaniel Popper for The New York Times: "Lost Passwords Lock Millionaires Out of Their Bitcoin Fortunes" Emily: Hamnet by Maggie O'Farrell David: The Dancing Bird of Paradise Scene from "Our Planet" Listener chatter from Richard Medlicott: Steven Levy for Wired: "A 25-Year-Old Bet Comes Due: Has Tech Destroyed Society?" Slate Plus members get a bonus segment on the Gabfest each week, and access to special bonus episodes throughout the year. Sign up now to listen and support our show. For this week's Slate Plus bonus segment David, Emily, and John talk about the music they turn to in order to clear their heads. You can tweet suggestions, links, and questions to @SlateGabfest. Tweet us your cocktail chatter using #cocktailchatter. (Messages may be quoted by name unless the writer stipulates otherwise.) The email address for the Political Gabfest is gabfest@slate.com. (Email may be quoted by name unless the writer stipulates otherwise.) Podcast production by Jocelyn Frank. Research and show notes by Bridgette Dunlap. Learn more about your ad choices. Visit megaphone.fm/adchoices
Reaping the Whirlwind
Emily, John and David discuss the invasion of the U.S. Capitol and Democrats' historic win in Georgia. Here are some notes and references from this week's show: Yuval Levin for the National Review: "Failures of Leadership in a Populist Age" Anne Applebaum for the Atlantic: "History Will Judge the Complicit" Emily Bazelon for the New York Times Magazine: "The Pandemic Election" Emily Bazelon for Slate in 2013: "Voting Rights 2.0" Steven Lance for Atavist: "The Secret Formula: Could Shrunken Heads From the Amazon Hold the Key to Curing Cancer? One Man Thought So—and Spent a Lifetime Trying to Prove It." A Midwife's Tale: The Life of Martha Ballard, Based on Her Diary, 1785-1812,by Laurel Thatcher Ulrich Here are this week's cocktail chatters: John: Agence France-Presse, "Exceptionally Well-Preserved Snack Bar Unearthed in Pompeii" David: David Segal for the New York Times: "It's Mother vs. Son in Britain's Priciest Divorce War" Emily: Tweet by Kyle Machulis @qDo of the most important competitive dog dancing video Listener chatter from Cyrus Farivar @cfarivar: Jason Kottke for Kottke.org: "The Last Documented Widow of a Civil War Veteran Has Died at the Age of 101" Slate Plus members get a bonus segment on the Gabfest each week, and access to special bonus episodes throughout the year. Sign up now to listen and support our show. For this week's Slate Plus bonus segment David, Emily, and John consider in what time period they would first go to see a doctor, given what we know now about the history of medicine. You can tweet suggestions, links, and questions to @SlateGabfest. Tweet us your cocktail chatter using #cocktailchatter. (Messages may be quoted by name unless the writer stipulates otherwise.) The email address for the Political Gabfest is gabfest@slate.com. (Email may be quoted by name unless the writer stipulates otherwise.) Podcast production by Jocelyn Frank. Research and show notes by Bridgette Dunlap. Learn more about your ad choices. Visit megaphone.fm/adchoices
Emily Bazelon, John Dickerson and David Plotz reminisce about 15 years of podcasting together. They look back on past mistakes and deliver fresh kindnesses. This live show was recorded on Dec 9, 2020. You can watch a special tribute video here and a video of the entire 15th Anniversary Show is here. Here are some references from this week's show: Jonathan Rauch for the Atlantic: "How American Politics Went Insane" Conor Friedersdorf for the Atlantic: "Working Mom Arrested for Letting Her 9-Year-Old Play Alone at Park" Here are this week's cocktail chatters: John: The Washington Post: "Sept. 8 in History: Evel Knievel's Canyon Jump, Nixon Pardon" Emily: Catrin Einhorn and Christopher Flavelle for The New York Times: "A Race Against Time to Rescue a Reef From Climate Change" David: Washington Post: "Plastic Surgeons Say Business Is Up, Partly Because Clients Don't Like How They Look On Zoom" Slate Plus members get a bonus segment on the Gabfest each week, and access to special bonus episodes throughout the year. Sign up now to listen and support our show. For this week's Slate Plus bonus segment David, Emily, and John share politically-themed cocktail recipes from listeners and of their own. You can tweet suggestions, links, and questions to @SlateGabfest. Tweet us your cocktail chatter using #cocktailchatter. (Messages may be quoted by name unless the writer stipulates otherwise.) The email address for the Political Gabfest is gabfest@slate.com. (Email may be quoted by name unless the writer stipulates otherwise.) Podcast production by Jocelyn Frank. Research and show notes by Bridgette Dunlap. Learn more about your ad choices. Visit megaphone.fm/adchoices

redpajama_set_name: RedPajamaCommonCrawl


We Saved You A Seat! The Women's Ministry is hosting their annual conference on Saturday, April 27 from 9:00 am – 3:00 pm. This will be a time of Bible study and fellowship and a celebration of friendship. Light morning snacks, lunch and drinks will be provided. The conference is based on We Saved You a Seat: Finding and Keeping Lasting Friendships by Lisa-Jo Baker. Registration is $20 until April 18, and increases to $25 after April 18 and at the door. We encourage you to bring a friend for free with your paid registration. A registration form is requested for each guest to allow for planning. Click here to find printable registration forms on our website.


text:
The Gift of Teaching and Coaching Tuesday, July 18, 2017
The Gift of Teaching and Coaching
Hosted by The Express Yourself! STAR On-Air Teen Team
Natalie Mitchell
Teachers are some of the greatest people with whom we will ever cross paths. Hosts Zahra Hasanian and Brigitte Jia interview triple threat actor, producer, and coach, Natalie Mitchell about her evolution from working as a child actor in the movie Jack with Robin Williams to becoming an acting coach, producer, director, and founder of her own production company, Emergence Films. Her insights on teaching and the entertainment industry are grounded in values and empowerment. Report of Music Magic, Seo Young Kim discusses how music fits as a unique type of strategy for teaching because it's collaborative, offering the opportunity to express opinions and relate to the listener. First time reporter of Ode to Literature, Caitlin Sim shares a very point that not every book that teaches is a philosophical or a political book. Many fiction novels are more frequently read than "non-fiction" books. Several book are discussed including Mitch Albom's book, Tuesdays with Morrie. Teach On!
Sunday at 3 PM Pacific Time on VoiceAmerica Empowerment Channel
Express Yourself! is an entertaining adolescent fusion program where passion, productivity, and possibility populate the airwaves. Produced by Starstyle Productions, LLC as an international outreach program of Be the Star You Are! charity, the radio program, Express Yourself! is a show for, by, and about teens. Hosted by teens and teenage field reporters from around the country, Express Yourself! is THE destination for teens to be heard. Within the walls of the young adult community, listeners are uplifted and encouraged to be the stars of your own life. Through collaboration and conversation, a global campus of young people express their views. Topics include anything that kids talk about-books, music, making a difference, technology, school, art, humor, writing, tough talks, health, sports, films, family, friends, foes, fashion, and fun. Come play in STAR country and Express Yourself!, Sundays at 3 PM Pacific on VoiceAmerica Empowerment.
The Express Yourself! STAR On-Air Teen Team
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ICTV doesn't have a licence, but it does have a website, where it lays out its plans. It is not yet incorporated, but it already has both a founding board and a steering committee.
Sabine Friesinger (the name under which the complaint was filed) and Laith Marouf are left-wing activists and former administrators at Concordia University Television and its parent the Concordia Student Broadcasting Corporation. They were instrumental in CUTV's coverage of the student strike in 2012. Previously, they were heavily involved in student politics at Concordia. Friesinger is a former president of the Concordia Student Union and Marouf is a former vice-president — and this dates back more than a decade.
Abby Lippman and Yakov Rabkin are professors. Lippman is on sabbatical retired from the faculty of medicine at McGill and is a research associate at Concordia's Simone de Beauvoir Institute. She's a self-described feminist and an activist on women's health issues. Rabkin is Professor of Contemporary History at Université de Montréal, and an expert on Zionism (which, based on his writings, he's pretty well against).
Jooneed Jeeroburkhan is a retired La Presse journalist and a human rights activist who has been accused of pushing at least one anti-Israel conspiracy theory.
Cathy Edwards, the executive director of the Canadian Association of Community Television Users and Stations (CACTUS), would be an advisor to the group, according to some documents.
Math whizzes out there might note that the numbers add up to 18, not 19. They should probably fix that before incorporating.
The group has a series of issues with MAtv, mostly related to aspects of the CRTC's community television policy that it has failed to meet.
CRTC policy requires that community channels like MAtv ensure that at least 45% of programming aired be "access" programming. On Sept. 1, that rises to 50%.
"Videotron fails to meet its minimum requirement for access programming within the Greater Montreal licence area" ICTV says. In fact, it says, its analysis of a week of broadcasting last fall shows MAtv didn't air a single program that qualifies as "access".
Videotron says that's nonsense, and its own analysis shows the same week had 59% of the programming qualify as access under the CRTC's guidelines, slightly higher than its average for the broadcast year of 57%.
So who's right? Well, the CRTC gets to decide that, of course. But ICTV's analysis shows where the two seem to disagree. The group disqualifies as "access programming" any show that has ties to any commercial entity or is produced by MAtv, neither of which would seem to disqualify it under the CRTC's criteria.
Exercise shows like Absolument Yoga, Pilates and Bébé Cardio are not access programs because they're hosted by people who run private fitness centres. ICTV considers that to mean their relationships with MAtv are commercial.
Selon l'opinion comique, the comic talk show produced by Juste Pour Rire TV, is commercial, employs unionized on-air personalities and receives government production tax credits, which disqualifies the show from being considered as an access program.
All other programs in Montreal are produced by MAtv and carry MAtv copyright, suggesting the shows are "under the creative control of Videotron staffers" and so do not qualify as access programs.
It bases these analyses off of nothing more than watching the shows and their credits, which could possibly be leading them to incorrect assumptions.
The CRTC's rules say there can be no advertising on community television channels. But shows can be sponsored. "Sometimes people bring us projects that involve a lot of advertising and we refuse them," said Steve Desgagné, general manager of MAtv.
The CRTC's community television policy mentions the word "volunteer" 16 times. It's clear that volunteer involvement is a key part of the policy, in spirit if not in rules.
But at least in Montreal, MAtv doesn't have much in the way of volunteering going on. ICTV's back-of-the-envelope calculations based on numbers Videotron submitted for MAtv (showing 103 volunteers contributing 4606 hours of work) suggest that very few volunteer-hours are going into each of the channel's programs. "The ratio of volunteers and their hours worked is extremely low for the number of programs taped," ICTV's complaint says.
In particular, ICTV looks at the behind-the-camera people, noting that it's the same people technically producing each show. These are paid staff of Videotron, not volunteers.
Desgagné didn't deny that there aren't a lot of volunteers at MAtv in Montreal on the technical side, though he pointed out that the show Catherine et Laurent, produced by community radio station CIBL, has "about 20 volunteers" working for it.
Instead, Desgagné said MAtv provides training opportunities to the community through internships.
MAtv currently airs no programming at all in any language other than French. It has no programming targetting the aboriginal community (Videotron supplied a list of only a handful of programs over the past four years that even included a segment dealing with aboriginal issues). And other than Couleurs d'ici, has nothing reflecting various cultural communities.
Not only does having one French channel and one English channel fail to factor in all the communities of people who speak different languages, but it needlessly separates those communities apart.
Here, ICTV is on the same wavelength as CACTUS, which has opposed the creation of multiple community channels to separate programming into two languages.
Videotron doesn't argue that it has failed to represent the anglophone community. But the application to create MYtv was supposed to be the solution to that problem. Once it gets off the ground, there will be plenty of English community programming in Montreal.
He said the anglo time block on MAtv didn't satisfy either language group, and so Videotron decided to go the MYtv route.
ICTV points out, and Videotron confirms, that no such advisory board exists for MAtv. Videotron has proposed one for MYtv, though members of the community were skeptical about this at a meeting in September because the advisory board would have no actual power over programming.
Desgagné said Videotron has committed to creating an advisory board for MAtv by Dec. 31.
Opportunities are useless if you don't know about them, and ICTV has expressed concern that Videotron is not doing enough to promote the access opportunities afforded by MAtv, essentially selling it as a regular television channel.
I get my Videotron bills electronically, so I don't get inserts. I certainly haven't seen one promoting community access on MAtv.
Clearly Videotron has taken note of the complaint here.
Videotron notes that it also promotes MAtv through social media, using Facebook and Twitter, and promotes access opportunities through on-air promos. And when they go to events, "we always take advantage to promote MAtv as community access programming," Desgagné said.
But the biggest way is through the MAtv website, because that's where most of the proposals for programs come from.
To make its case that Videotron is failing to represent the anglophone community, ICTV's complaint includes reference to a complaint written by Jason Gondziola of CUTV in 2009, saying he made proposals to Vox/MAtv that were ignored.
Desgagné said he's been in office two years and can't speak to what happened before he got there, but he hasn't received any proposals from CUTV or ICTV since he started working in his job. He said he's open to receiving them, despite the heated rhetoric in front of the CRTC.
The CRTC asked Videotron to compile a list of all proposals made from Sept. 1, 2013 to Feb. 14, 2014, and say what happened to them, giving reasons for those that were rejected.
The list provided included 37 projects submitted for the island of Montreal. Of them, four were accepted, four others were marked "to be developed", and five were to be combined with other proposals or with existing programs.
Seven others had not yet been evaluated.
Of the remaining 17 that were rejected, the reasons for doing so matched what Desgagné told me: Either they duplicate existing shows, they don't fit the mandate or they're too expensive or impractical to produce.
We shouldn't read anything statistically into the rejections. But they're interesting from a qualitative perspective. Among the series rejected are a documentary series about family life (more suited to Canal Vie, MAtv said), a documentary about aging in Quebec, France and Switzerland (not local and too expensive), a trade-places-with-a-celebrity-for-a-day show (not a community show, too expensive), and shows that MAtv deemed beyond its technical capacity to produce: a show about cultural personalities sitting down to dinner together, an interview show featuring where-are-they-now celebrities, and a vegetarian recipes show. The devil may be in the details about why they can't be produced by MAtv.
Ambitious is putting it mildly. ICTV will commit to a community channel that provides live coverage of events, representation from every community, and 70 hours per week of original programming (more than three times what we see on MAtv). And it would expect to be on the air nine months after getting CRTC approval and funding.
I won't get into too much detail because a lot of it is vague and so much of it seems unlikely to make it to air. But the group is definitely committed to the community programming spirit.
The plan will have to wait, though. Videotron's public process is about the complaint against MAtv, not ICTV's application for a new licence. The course of the latter will undoubtedly be affected by the decision on the former.
Videotron won't say what MAtv's budget is for Montreal. ICTV estimated it at $23 million a year using a very general (and very flawed) calculation based on average cable bills and the population of Montreal. Desgagné said this isn't even close to the real figure.
But we can infer the amount of money involved. Quebecor's report to the CRTC shows $23,371,000 in contributions to its community television channel throughout Quebec. If we assume that, with 23% of the population of Quebec living on the island of Montreal, that 23% of MAtv funding goes to its Montreal channel, that would work out to about $5.4 million.
More telling, at the meeting with ELAN in September, Videotron said the budget for MYtv, which would also operate in he Montreal area, would be about $6 million a year. So it's safe to say that we're talking about a number that is around this figure for each of MAtv and MYtv in Montreal. That number would get bigger if ICTV wants to take over community channels in neighbouring communities like the south shore, Laval, Terrebonne and Châteauguay, though these areas have community television groups operating in them.
One thing I wondered about this group is why it hasn't gone after Bell, which has also proposed a community television service in each language for its Bell Fibe subscribers in Montreal.
Unlike Videotron, Bell's community channel isn't a linear channel. Instead, it's a series of videos made available on its video-on-demand service. The CRTC deemed it acceptable to do it this way, even though not finding a channel on the channel grid will likely mean much less viewership.
ICTV didn't really have an answer to that question. I suspect they haven't really looked into it much yet, having focused so much on Videotron. If this complaint is successful, Bell could easily be their next target.
It seems like a long shot to think that the CRTC will just yank Videotron's licence for MAtv. A more realistic scenario is that the CRTC imposes new conditions on Videotron, or clarifies rules about community television.
ICTV and CACTUS have also left open the possibility of a compromise whereby MAtv would be allowed to continue but ICTV would replace MYtv and get its funding.
Where there is one or more local not-for-profit community television corporations (TVCs) in a given licensed area, up to 20% of the programming aired during each broadcast week by licensees shall be made available for access programs from these TVCs. Where more than one TVC is in operation in a licensed area, each must be guaranteed a minimum of four hours of access programs per broadcast week, upon request. This 20% is considered part of the access program requirements set out above.
So ICTV would be given up to three and a half hours a day (assuming an 18-hour broadcast day) of programming on MAtv.
Funding isn't as clearly spelled out. Rules require at least half of programming expenditures be given to access programming, but it's not made clear that the funding for independent community television corporations should be proportional to their airtime. I would suspect that it would be, though, and another complaint would be forthcoming if Videotron tried to discriminate in its funding allocation. Its report to the CRTC suggests that funding is about proportional to airtime.
MAtv's Desgagné has made it clear he's willing to work together, and said they even approached CUTV to get them involved.
ICTV's willingness to work together this way is unclear, but King said "we would still be interested in pursuing community television licensing for Montreal" even if the complaint is rejected.
What is community TV about?
Reading all these documents, it seems clear to me that this is an argument about the fundamentals of community television. ICTV and CACTUS don't seem to like the rules as they're written now, and have complained even though Videotron is following the letter of those rules.
It's a big question: Is community television about service to a community, providing local information in a professional way with the help of money from cable TV distributors? Or is it about access, giving any guy off the street half an hour a week to talk about whatever he wants?
It's a question I don't have an answer to. But the CRTC is in the process of a wide-ranging review of television policy, and this could be one of the issues it decides to tackle, especially if it finds that cable companies are following the letter of the law while ignoring its spirit.
The CRTC is accepting comments on the ICTV complaint against MAtv (which you can download here) until April 10 April 22. (ICTV had asked for an extension to April 17, since Videotron got a one-week extension on submitting information, but that request was denied. The CRTC later extended the deadline anyway when it decided to seek more information from Videotron, to be submitted by April 7.) The file number is 2013-1746-2. You can submit comments online here. Remember that all information submitted goes on the public record.
ICTV's website is tele1.ca. It includes the individual files submitted to the CRTC as part of the complaint.
I've heard talk alluding to Anglos dumping their Videotron subscriptions in favor of Bell since PKP has joined the Provincial race. Have you heard anything to that?!
At this point there's only anecdotal evidence of this. There would need to be 20,000 people doing this to result in even a 1% drop in Videotron subscriptions.
I dumped mine. so only 19,999 to go!
I get paper statements, and I've never seen an insert.
So after Marouf lost his position at CUTV due to complaints (http://thelinknewspaper.ca/article/3918), he and his radical supporters are trying to find a new source of funding for themselves on the pretext of being better representatives of the "community". How rich.
The real issue here is that a resource that is suppose to be about and for the community looks like more and more it's becoming a profit center for the distribution companies. Basically, they take funds that would be given to others (Canadian production fund) and turn it into internal funds. At bare minimum, it means that 50% of the funds end up back in the company to produce shows inside rather than outside. As this report suggests, the rules from the CRTC do seem to let that number slip even further.
If community TV was a big money loser (and technically it should be), neither Bell nor Videotron would be working to add community programming. When everyone is heading that way, you know there is a bottom line concept in play.
1) have a community programming organization (non-profit) created in each part of the country, generally by city. That group would be funded by funds from distributors and other local stations.
2) This independent group would produce at least 1 channel, and possibly 2 channels of programming. In Montreal, example, they might produce 2 channels, one rooted in english, one rooted in french, with other languages thrown in.
3) Mandate the two largest broadcasters (CTV and TVA) to provide a digital sub-channel each for this service on their broadcast antennas, assuring good coverage to both cable and non-cable users.
5) Free Bell, Videotron, and others from the responsiblity to operate a community channel of their own. They can still do so at their cost, but they can no longer divert funds from other commitments to support it.
The problem we face right now is that the community channels are splintered by distributor, and again by language, which means that at best these channels will get very low viewership each. Moreover, with no OTA presence, these channels are essentially unknown beyond their cable systems, and generally not promoted unless forced by the CRTC.
it's time for the CRTC to serious look at mandating certain public service uses for sub-channels on major broadcasters. The technology exists to give Canadians much more, time to move forward if you want to keep OTA relevant and keep community channels actually serving the community.
It's not that community TV makes money for them, it's that they have to spend the money anyway, and they prefer to keep it in-house and give their customers some added value than simply hand over the money to the Canada Media Fund.
have a community programming organization (non-profit) created in each part of the country, generally by city. That group would be funded by funds from distributors and other local stations.
CACTUS certainly leans in that direction, and wants non-profit independent community TV producers. But what about cities where you can't find someone to run a community TV station? What do you do about the inevitable loss of quality or failure to meet regulatory obligations because the station employs volunteers instead of professionals?
Mandate the two largest broadcasters (CTV and TVA) to provide a digital sub-channel each for this service on their broadcast antennas, assuring good coverage to both cable and non-cable users.
Both CTV and TVA would strongly object to such an imposition. Plus, the signals would only be available in Canada's largest cities, which already have a local TV station. Community television is more important in smaller regions than big cities. Considering 90% of Canadians have a TV subscription, I think the current system works pretty well.
Did you have a straight face when you said that? It read like a press release.
It's all about keeping control of the money, and having it "leak" to the bottom line. Keeping it in house has significant enough impact for larger cable companies that they are tripping over themselves to find ways to double their community channels.
For those places where there is no OTA broadcaster, the "community" aspect is pretty weak anyway. Bell isn't going to make a new community channel for each berg in Canada, are they? They would make a limited number to cover large areas. Also, many of the small cable systems are exempt from community channel requirements anyway, and generally don't have them.
yes, it works very well. The average person doesn't know about the community channels, won't know what's on, and is equally likely not to have the right system (Bell, Videotron) to view a specific program. Massive fragmentation, 100% duplication of efforts… basically twice the staff for half the coverage. If by "working well" you mean "totally obscure and unwatched" then you are about right. Does Montreal really need 4 different community channels on two different distribution systems that aren't shared? Would it not be better at bare minimum for Bell and Videotron to share the community channels so that the programming gets a wider audience?
Nahh, we don't want people watching commuinity programming, we just want to go through the motions and keep the money in house.
It's all about keeping control of the money, and having it "leak" to the bottom line.
MAtv lost money last year. I don't see how that improves Videotron's bottom line.
Keeping it in house has significant enough impact for larger cable companies that they are tripping over themselves to find ways to double their community channels.
Well, not exactly tripping over themselves. They've done it in Montreal and Ottawa, and Rogers has done it in Moncton. These are the country's most bilingual areas. If this was really some super-evil secret slush fund as you're implying, we'd probably see Rogers with a French channel in Toronto, or Shaw with a French channel in B.C. and Alberta.
There's obviously an incentive to keep community television in-house, but there isn't yet any incentive to provide community television service to communities without enough population to supply programming.
For those places where there is no OTA broadcaster, the "community" aspect is pretty weak anyway. Bell isn't going to make a new community channel for each berg in Canada, are they?
Bell is starting with Canada's largest cities in rolling out its Fibe network, so it's not going to have community channels in small cities yet. But Videotron, Cogeco and Rogers have plenty of community channels in small areas. Videotron alone has 35 community channels.
If by "working well" you mean "totally obscure and unwatched" then you are about right.
Show me somewhere where a public-access community television channel is popular.
Does Montreal really need 4 different community channels on two different distribution systems that aren't shared? Would it not be better at bare minimum for Bell and Videotron to share the community channels so that the programming gets a wider audience?
Probably. CACTUS has argued to the CRTC that we shouldn't have community channels run by cable companies for that reason. We'll see if the CRTC looks into that in its review of the television system.
If by popular you mean "pulls like CSI or Greys Anatomy" then no, they aren't popular. However, taking a small audience and making the channels unavailable to more than half of the people up front is pretty much a way to assure that your audience is small. Give it no promotion, give it no exposure, and yup, few people watch.
Well, it depends on the scope of how you look at it. You always have the question of what proportion of shared expenses (studio space, office space, etc) are pushed onto the stations from the parent. It's a pretty big issue, because a community channel saving pennies might not be located in prime real estate, whereas Videotron may be just that. It's hard to break down because you would have to look at each line expense to see how much ends up back in the pocket of Videotron to pay for overall operating expenses. Is MaTV an actually seperate company, or just part of the whole? Do they actually report their individual line item expenses, or is it just rolled up into Videotron itself?
I really appreciate the coverage that Steve has provided to this important issue in the Montreal Gazette, as well as the thorough consideration he has given to TVCI-ICTV's application.
1) Videotron is not just in violation of the "spirit" of community TV policy, but the "letter" too. Make no mistake. Virtually every program in the week examined by TVCI-ICTV gives a Videotron's staffer's name as the producer, OR the name of a Union des Artiste or Fédération des Journalistes de Québec member with a long history of work in broadcasting as the host, and is surely paid. The CRTC's community TV policy is very clear that it is the ordinary citizen's participation on the channel that makes 'community TV' what it is, and that creative control is to be in the hands of community members who are VOLUNTEERS. If a program host merely being resident in the city (aka a "community member") were the criterion for access, every program locally produced on most stations (e.g. news) would be "community programming" and that is just not so.
Furthermore, the Code of Access Best Practices that governs the CRTC's community channel policy states the community producer for each "access" program retains control of the program's copyright. As Steve acknowledges, almost every single program aired on MAtv ends with the MAtv logo, with a couple of exceptions, such as the Just for Laughs-produced program, which is produced by a fully professional entity and an all-paid staff.
Aside from the requirement that at east 45% of MAtv's programming be genuinely be under the creative control of volunteers, MAtv is also supposed to reflect the multicultural and multilingual character of the licence area, giving special consideration to Aboriginal programming (an explicit CRTC request at the time of MAtv's last licence renewal in 2006). The fact that it does not do so (as Steve acknowledges) also puts Videotron in non-compliance with the conditions of its licence.
2) Steve appears to be calling into question the professionalism of the ICTV-TVCI team and its proposal. He says that the proposal is "ambitious" and concludes by saying "Is community television about service to a community, providing local information in a professional way with the help of money from cable TV distributors? Or is it about access, giving any guy off the street half an hour a week to talk about whatever he wants?" The implication is that if you let "any guy off the street" have "have an hour to talk about whatever he wants" that the results won't be professional (and furthermore, that this is what ICTV-TVCI is proposing).
In fact, if you compare ICTV-TVCI's detailed supplementary brief (with 25 pages about how it would handle everything from language, to volunteers, training, and programming) to Videotron's four-page proposal for an English clone of MAtv (with no description of training, volunteerism, nor programming plan), ICTV-TVCI looks by far the more professional of the two. In fact, there's no comparison.
Many people seem to think that 'community TV' means amateur. It doesn't. In fact, it's a highly skilled sector where the employees of a community TV channel have the challenge of taking the raw ideas of the public, and helping that public develop those ideas and make them accessible for TV. Cable companies over the last decade have been showing that they're not very good at doing that, and seem to have no confidence that it can even be done, which is why they have systematically taken over control of these branded, sponsorship-riddled platforms. What community programming practitioners from around the globe know (you can take advanced degrees in how to promote and manage citizen media) is that it can be done, to the benefit of both audiences and to the enormous and lasting benefit of all parts of the community involved in the process. It's not about entertainment as a deliverable, it's about dialogue as a process. This is what cable companies have forgotten. The TVCI-ICTV team are full professional in this field, with many combined years of both practical and theoretical experience. They're the right team to fulfill this important mandate in Montreal and the city is very lucky to have them in my view.
If community TV were managed by communities themselves, they would be accountable and answerable to their own boards of directors, which by CRTC mandate, would be open to all. This is how community radio works in Canada, and how community TV works in every other developed and developing country that has it. The transition to this model should have happened in 1991 when the Broadcasting Act was written. It's a change that's long overdue, and then we wouldn't have to be spending taxpayer and subscriber dollars squabbling about. We could just get on with letting ordinary citizens participate meaningfully in public discourse. Don't we deserve it?
Videotron is not just in violation of the "spirit" of community TV policy, but the "letter" too. Make no mistake. Virtually every program in the week examined by TVCI-ICTV gives a Videotron's staffer's name as the producer, OR the name of a Union des Artiste or Fédération des Journalistes de Québec member with a long history of work in broadcasting as the host, and is surely paid.
I've read the CRTC community television policy a few times, and can't find anywhere where it says that people can't be paid for community access programming, or that such programming can't come from people who are professional artists.
The CRTC's community TV policy is very clear that it is the ordinary citizen's participation on the channel that makes 'community TV' what it is, and that creative control is to be in the hands of community members who are VOLUNTEERS.
It is indeed very clear on the first part. It is not clear on the second. I can't find a regulation that requires that the people with creative control over access programs must all be volunteers, only that they come from the community and are not employed by the distributor.
Furthermore, the Code of Access Best Practices that governs the CRTC's community channel policy states the community producer for each "access" program retains control of the program's copyright.
Indeed. MAtv confirmed to me today that the creators of MAtv's access shows retain copyright to them.
That could mean a lot of things though. MAtv tells me that they will be making changes to their end-of-show credits to make things clearer.
MAtv is also supposed to reflect the multicultural and multilingual character of the licence area, giving special consideration to Aboriginal programming (an explicit CRTC request at the time of MAtv's last licence renewal in 2006). The fact that it does not do so (as Steve acknowledges) also puts Videotron in non-compliance with the conditions of its licence.
Since the CRTC doesn't set any quantitative measure for this, it will be up to the commission to decide if MAtv is in non-compliance. Its case is certainly somewhat weak in this regard based on what I've seen so far.
Steve appears to be calling into question the professionalism of the ICTV-TVCI team and its proposal. He says that the proposal is "ambitious" and concludes by saying "Is community television about service to a community, providing local information in a professional way with the help of money from cable TV distributors? Or is it about access, giving any guy off the street half an hour a week to talk about whatever he wants?" The implication is that if you let "any guy off the street" have "have an hour to talk about whatever he wants" that the results won't be professional (and furthermore, that this is what ICTV-TVCI is proposing).
The basis for ICTV's complaint is that Videotron is not providing access programming and is run by professionals. Presumably this means that ICTV's programming will be produced by non-professionals.
I'm not saying that ICTV's programs will be of poor quality. I'm asking what barrier we should set to access programming. Should we set it high, requiring a high quality of production, or low, ensuring as much access as possible? There are arguments for both.
Many people seem to think that 'community TV' means amateur. It doesn't.
I think the very definition of amateur references the fact that it means non-professional and unpaid. Since ICTV says community television shouldn't be done by professionals and shouldn't be paid, how is that wrong?
Maybe there's some distinction to be made between the ICTV team itself and the community it serves. But since ICTV wants community volunteers to be involved in all aspects of the organization, from being on the board of directors to working technical jobs, I don't see where I can draw a line here.


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Welcome to the Cochrane restaurant dining guide! Here you'll find the best Cochrane restaurants, as well as the newest and most recently reviewed Cochrane-area restaurants.
Dine out using the Cochrane restaurant reservations list or order in from Cochrane food delivery restaurants.
A diner from Calgary, AB tried Olive R Twist.
A Pizza chowhound from Edmonton, AB tried Boston Pizza, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
A dining patron from Cochrane, AB tried Ducks on the Roof, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
A diner from Seattle, WA tried Ducks on the Roof.
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A Canadian chowhound from Seattle, WA tried Prairie Smoke Country Kitchen.
A food lover from Burnaby, BC tried Ducks on the Roof.
A chowhound from CA tried Ducks on the Roof, liked it, and rated it . They liked the food, liked the service, and liked the ambiance.
A food lover from Taber, AB tried Ducks on the Roof and liked it. They liked the food.
A chowhound from Calgary, AB tried Ducks on the Roof, liked it, and rated it . They liked the food and liked the ambiance.
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George T. Stayton of Delanco passed away on Thursday, March 28, 2013. He was 50.
He was an equipment operator and truck driver for various companies.
He was a member of the Brotherhood Local 676 of N.J. Operating Engineers of Collingswood, N.J.
He loved to play pool and enjoyed being around people.
He was the beloved father of Bryan Stayton of Kansas; son of Ruth (Stockdale) Stayton of Delanco and the late Lewis J. Stayton; and the brother of William 'Pete' Stayton of Delanco, Lewis J. Allen Stayton of Ohio and Thomas Stayton of Riverside, Rosemary Williams (Douglas) of San Diego, Calif., and Luanne Butler of California.
Friends of the family are cordially invited to celebrate George's life in a visitation 10 to 11 a.m., Saturday followed by a memorial service at 11 a.m., at Chadwick Memorial Home, 154 Webster St., Riverside. Interment will be private.


text:
Jerusalem Township ist der Name folgender Townships in den Vereinigten Staaten:

 Jerusalem Township (North Carolina)
 Jerusalem Township (Ohio)

redpajama_set_name: RedPajamaWikipedia


text:
Q: How can I attach the scroll function to the views in SAPUI5? This is what I am doing in the controller.
onAfterRendering: function(){
   this.getView().attachBrowserEvent("window.onscroll", function(){
        alert('scrolled');
   });
}

It does nothing. Want to know what I am doing wrong.

A: Hi you can use a scroll container instead of event if that is your requirement, look at the link below for api
https://sapui5.hana.ondemand.com/#/api/sap.m.ScrollContainer
example
https://sapui5.hana.ondemand.com/#/sample/sap.m.sample.ScrollContainer/code
You can put n number of content in the scroll container.
Hope this helps.

redpajama_set_name: RedPajamaStackExchange


text:
Profitroom backs Boutique Hotelier Awards 2021 in General Manager of the Year sponsorship
EVENTSTECHNOLOGY by Zoe Monk	on August 19, 2021
Booking system software company Profitroom has come on board to sponsor the first Boutique Hotelier Awards 2021, taking place this October in London.
New for this year, The Boutique Hotelier Awards will reward the best hotels in the country, recognise the most innovative new products and mark the achievements of excellent staff and employers in the hospitality sector, after an incredibly challenging year.
Now Profitroom will support the General Manager of the Year category and present the award to the winner on the night of October 4, at the event held at Chelsea Harbour Hotel.
The team at Profitroom, which is known in the hospitality sector for its booking engine 360 and other technologies to help hoteliers streamline services, said they were 'excited' to support the awards this year and 'shine a light on the incredible achievements of the UK hospitality industry'.
A spokesperson said: "Profitroom have a renewed focus to build long term partnerships with hotels and hoteliers.
As an organisation Profitroom has an array of hospitality talent including former revenue managers, sales and marketing directors, operations managers and of course, general managers. With this extensive hospitality industry knowledge, the organisation is in a unique position to not only provide the technological solutions to help hoteliers reach the next level, but also the knowledge and understanding to help across all areas of a hotel business.
"As a result of this renewed focus, Profitroom felt the chance to support the General Manager of the Year award was the natural conclusion.
"Listening to the needs of hoteliers, Profitroom has developed an entire hotel technology ecosystem that is easy to use, reliable and hassle free. Effortlessly connecting sales, marketing, revenue and the overall guest experience, all in one place."
The Boutique Hotelier Awards 2021 will be black tie and will include a sparkling champagne reception and three-course dinner, as well as the presentation of awards to the country's best hotels and spas, alongside the greatest brands they sell.
Key members of staff and teams will also be applauded.
The event will be a fantastic opportunity to catch up and socialise with colleagues and peers as well as meeting new faces for the first time in over a year.
During the ceremony we will present awards across 12 dedicated hotel and supplier categories, as well as a special Lifetime Achievement Award.
For tickets and sponsorship opportunities, contact Richelle Rimmer Richelle.rimmer@itppromedia.com
Tags : Boutique Hotelier Awards 2021eventsTECHNOLOGY
The Cloud Hotel in the New Forest comes to market with £2.35m price tag
House of Gods in Edinburgh pays homage to 'club scene of LA' with launch of new cocktail club
How to make your guests feel safe this season
Hotel technology roundtable: How to keep your hotel on track with tech
Annual Master Chefs of Great Britain charity lunch to return in 2022
Hotel technology trends: The best software for hoteliers


text:
Q: How to make next step of a string. C# The question is complicated but I will explain it in details.
The goal is to make a function which will return next "step" of the given string.
For example
String.Step("a"); //  = "b"
String.Step("b"); //  = "c"
String.Step("g"); //  = "h"
String.Step("z"); // = "A"
String.Step("A"); // = "B"
String.Step("B"); // = "C"
String.Step("G"); // = "H"

Until here its quite easy, But taking in mind that input IS string it can contain more than 1 characters and the function must behave like this.
String.Step("Z"); // = "aa";
String.Step("aa"); // = "ab";
String.Step("ag"); // = "ah";
String.Step("az"); // = "aA";
String.Step("aA"); // = "aB";
String.Step("aZ"); // = "ba";
String.Step("ZZ"); // = "aaa";

and so on...
This doesn't exactly need to extend the base String class.
I tried to work it out by each characters ASCII values but got stuck with strings containing 2 characters.
I would really appreciate if someone can provide full code of the function.
Thanks in advance.
EDIT
*I'm sorry I forgot to mention earlier that the function "reparse" the self generated string when its length reaches n.
continuation of this function will be smth like this. for example n = 3
String.Step("aaa"); // = "aab";
String.Step("aaZ"); // = "aba";
String.Step("aba"); // = "abb";
String.Step("abb"); // = "abc";
String.Step("abZ"); // = "aca";
.....
String.Step("zzZ"); // = "zAa";
String.Step("zAa"); // = "zAb";
........

I'm sorry I didn't mention it earlier, after reading some answers I realised that the problem was in question.
Without this the function will always produce character "a" n times after the end of the step.

A: Quite collection of approaches, here is mine:-
The Function:
private static string IncrementString(string s)
{
  byte[] vals = System.Text.Encoding.ASCII.GetBytes(s);
  for (var i = vals.Length - 1; i >= 0; i--)
  {
    if (vals[i] < 90)
    {
      vals[i] += 1;
      break;
    }
    if (vals[i] == 90)
    {
      if (i != 0)
      {
        vals[i] = 97;
        continue;
      }
      else
      {
        return new String('a', vals.Length + 1);
      }
    }

    if (vals[i] < 122)
    {
      vals[i] += 1;
      break;
    }

    vals[i] = 65;
    break;
  }

  return System.Text.Encoding.ASCII.GetString(vals);
}

The Tests
Console.WriteLine(IncrementString("a") == "b");
Console.WriteLine(IncrementString("z") == "A");
Console.WriteLine(IncrementString("Z") == "aa");
Console.WriteLine(IncrementString("aa") == "ab");
Console.WriteLine(IncrementString("az") == "aA");
Console.WriteLine(IncrementString("aZ") == "ba");
Console.WriteLine(IncrementString("zZ") == "Aa");
Console.WriteLine(IncrementString("Za") == "Zb");
Console.WriteLine(IncrementString("ZZ") == "aaa");

A: public static class StringStep
{
    public static string Next(string str)
    {
        string result = String.Empty;
        int index = str.Length - 1;
        bool carry;
        do
        {
            result = Increment(str[index--], out carry) + result;
        }
        while (carry && index >= 0);
        if (index >= 0) result = str.Substring(0, index+1) + result;
        if (carry) result = "a" + result;
        return result;
    }

    private static char Increment(char value, out bool carry)
    {
        carry = false;
        if (value >= 'a' && value < 'z' || value >= 'A' && value < 'Z')
        {
            return (char)((int)value + 1);
        }
        if (value == 'z') return 'A';
        if (value == 'Z')
        {
            carry = true;
            return 'a';
        }
        throw new Exception(String.Format("Invalid character value: {0}", value));
    }
}

A: NOTE: This answer is incorrect, as "aa" should follow after "Z"... (see comments below)
Here is an algorithm that might work:
each "string" represents a number to a given base (here: twice the count of letters in the alphabet).
The next step can thus be computed by parsing the "number"-string back into a int, adding 1 and then formatting it back to the base.
Example:
"a" == 1 -> step("a") == step(1) == 1 + 1 == 2 == "b"

Now your problem is reduced to parsing the string as a number to a given base and reformatting it. A quick googling suggests this page: http://everything2.com/title/convert+any+number+to+decimal
How to implement this?

*

*a lookup table for letters to their corresponding number: a=1, b=2, c=3, ... Y = ?, Z = 0

*to parse a string to number, read the characters in reverse order, looking up the numbers and adding them up:

*

*"ab" -> 2*BASE^0 + 1*BASE^1

*with BASE being the number of "digits" (2 count of letters in alphabet, is that 48?)

EDIT: This link looks even more promising: http://www.citidel.org/bitstream/10117/20/12/convexp.html

A: Split the input string into columns and process each, right-to-left, like you would if it  was basic arithmetic.  Apply whatever code you've got that works with a single column to each column.  When you get a Z, you 'increment' the next-left column using the same algorithm.  If there's no next-left column, stick in an 'a'.

A: You need to account for A) the fact that capital letters have a lower decimal value in the Ascii table than lower case ones. B) The table is not continuous A-Z-a-z - there are characters inbetween Z and a.
public static string stepChar(string str)
{
  return stepChar(str, str.Length - 1);
}

public static string stepChar(string str, int charPos)
{
  return stepChar(Encoding.ASCII.GetBytes(str), charPos);
}

public static string stepChar(byte[] strBytes, int charPos)
{
  //Escape case
  if (charPos < 0)
  {
    //just prepend with a and return
    return "a" + Encoding.ASCII.GetString(strBytes);
  }
  else
  {

    strBytes[charPos]++;

    if (strBytes[charPos] == 91)
    {
      //Z -> a plus increment previous char
      strBytes[charPos] = 97;
      return stepChar(strBytes, charPos - 1);                }
    else
    {
      if (strBytes[charPos] == 123)
      {
        //z -> A
        strBytes[charPos] = 65;
      }

      return Encoding.ASCII.GetString(strBytes);
    }
  }
}

You'll probably want some checking in place to ensure that the input string only contains chars A-Za-z

Edit Tidied up code and added new overload to remove redundant byte[] -> string -> byte[] conversion
Proof http://geekcubed.org/random/strIncr.png

A: I'm sorry the question is stated partly.
I edited the question so that it meets the requirements, without the edit the function would end up with a n times by step by step increasing each word from lowercase a to uppercase z without "re-parsing" it.
Please consider re-reading the question, including the edited part

A: This is what I came up with.  I'm not relying on ASCII int conversion, and am rather using an array of characters.  This should do precisely what you're looking for.
    public static string Step(this string s)
    {
        char[] stepChars = "abcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZ".ToCharArray();

        char[] str = s.ToCharArray();
        int idx = s.Length - 1;

        char lastChar = str[idx];

        for (int i=0; i<stepChars.Length; i++)
        {
            if (stepChars[i] == lastChar)
            {
                if (i == stepChars.Length - 1)
                {
                    str[idx] = stepChars[0];
                    if (str.Length > 1)
                    {
                        string tmp = Step(new string(str.Take(str.Length - 1).ToArray()));
                        str = (tmp + str[idx]).ToCharArray();
                    }
                    else
                        str = new char[] { stepChars[0], str[idx] };
                }
                else
                    str[idx] = stepChars[i + 1];

                break;
            }
        }

        return new string(str);
    }

A: This is a special case of a numeral system. It has the base of 52. If you write some parser and output logic you can do any kind of arithmetics an obviously the +1 (++) here.
The digits are "a"-"z" and "A" to "Z" where "a" is zero and "Z" is 51
So you have to write a parser who takes the string and builds an int or long from it. This function is called StringToInt() and is implemented straight forward (transform char to number (0..51) multiply with 52 and take the next char)
And you need the reverse function IntToString which is also implementet straight forward (modulo the int with 52 and transform result to digit, divide the int by 52 and repeat this until int is null)
With this functions you can do stuff like this:
IntToString( StringToInt("ZZ") +1 ) // Will be "aaa"

A: This is a lot like how Excel columns would work if they were unbounded.  You could change 52 to reference chars.Length for easier modification.
static class AlphaInt {
    private static string chars =
        "abcdefghijklmnopqrstuvwxyzABCDEFGHIJKLMNOPQRSTUVWXYZ";

    public static string StepNext(string input) {
        return IntToAlpha(AlphaToInt(input) + 1);
    }

    public static string IntToAlpha(int num) {
        if(num-- <= 0) return "a";
        if(num % 52 == num) return chars.Substring(num, 1);
        return IntToAlpha(num / 52) + IntToAlpha(num % 52 + 1);
    }

    public static int AlphaToInt(string str) {
        int num = 0;
        for(int i = 0; i < str.Length; i++) {
            num += (chars.IndexOf(str.Substring(i, 1)) + 1)
                   * (int)Math.Pow(52, str.Length - i - 1);
        }
        return num;
    }
}

A: LetterToNum should be be a Function that maps "a" to 0 and "Z" to 51.
NumToLetter the inverse.
long x = "aazeiZa".Aggregate((x,y) => (x*52) + LetterToNum(y)) + 1;
string s = "";

do { // assertion: x > 0
    var c = x % 52;
    s = NumToLetter() + s;
    x = (x - c) / 52;
} while (x > 0)

// s now should contain the result