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Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy
Karson S Putt1,
Grace W Chen2,
Jennifer M Pearson2,
Joseph S Sandhorst2,
Martin S Hoagland3,
Jung-Taek Kwon4,
Soon-Kyung Hwang4,
Hua Jin4,
Mona I Churchwell5,
Myung-Haing Cho4,
Daniel R Doerge5,
William G Helferich3 &
Paul J Hergenrother1,2
Nature Chemical Biology volume 2, pages543–550(2006)Cite this article
Mutation and aberrant expression of apoptotic proteins are hallmarks of cancer. These changes prevent proapoptotic signals from being transmitted to executioner caspases, thereby averting apoptotic death and allowing cellular proliferation. Caspase-3 is the key executioner caspase, and it exists as an inactive zymogen that is activated by upstream signals. Notably, concentrations of procaspase-3 in certain cancerous cells are significantly higher than those in noncancerous controls. Here we report the identification of a small molecule (PAC-1) that directly activates procaspase-3 to caspase-3 in vitro and induces apoptosis in cancerous cells isolated from primary colon tumors in a manner directly proportional to the concentration of procaspase-3 inside these cells. We found that PAC-1 retarded the growth of tumors in three different mouse models of cancer, including two models in which PAC-1 was administered orally. PAC-1 is the first small molecule known to directly activate procaspase-3 to caspase-3, a transformation that allows induction of apoptosis even in cells that have defective apoptotic machinery. The direct activation of executioner caspases is an anticancer strategy that may prove beneficial in treating the many cancers in which procaspase-3 concentrations are elevated.
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Figure 1: PAC-1 activates procaspase-3 in vitro.
Figure 2: PAC-1 induces apoptosis in HL-60 cells.
Figure 4: PAC-1 induces death in cells isolated from freshly resected colon tumors.
Figure 5: PAC-1 significantly retards tumor growth in three mouse models of cancer.
Hanahan, D. & Weinberg, R.A. The hallmarks of cancer. Cell 100, 57–70 (2000).
Lowe, S.W., Cepero, E. & Evan, G. Intrinsic tumor suppression. Nature 432, 307–315 (2004).
Vogelstein, B. & Kinzler, K.W. Achilles' heel of cancer. Nature 412, 865–866 (2001).
Traven, A., Huang, D.C. & Lithgow, T. Protein hijacking: key proteins held captive against their will. Cancer Cell 5, 107–108 (2004).
Soengas, M.S. et al. Inactivation of the apoptosis effector Apaf-1 in malignant melanoma. Nature 409, 207–211 (2001).
Wajant, H. Targeting the FLICE inhibitory protein (FLIP) in cancer therapy. Mol. Interv. 3, 124–127 (2003).
Okada, H. & Mak, T.W. Pathways of apoptotic and non-apoptotic death in tumour cells. Nat. Rev. Cancer 4, 592–603 (2004).
Denicourt, C. & Dowdy, S.F. Targeting apoptotic pathways in cancer cells. Science 305, 1411–1413 (2004).
Green, D.R. & Kroemer, G. Pharmacological manipulation of cell death: clinical applications in sight? J. Clin. Invest. 115, 2610–2617 (2005).
Vassilev, L.T. et al. In vivo activation of the p53 pathway by small-molecule antagonists of MDM2. Science 303, 844–848 (2004).
Degterev, A. et al. Identification of small-molecule inhibitors of interaction between the BH3 domain and Bcl-XL. Nat. Cell Biol. 3, 173–182 (2001).
Becattini, B. et al. Rational design and real time, in-cell detection of the proapoptotic activity of a novel compound targeting Bcl-XL. Chem. Biol. 11, 389–395 (2004).
Wang, J.-L. et al. Structure-based discovery of an organic compound that binds Bcl-2 protein and induces apoptosis of tumor cells. Proc. Natl. Acad. Sci. USA 97, 7124–7129 (2000).
Li, L. et al. A small molecule Smac mimic potentiates TRAIL- and TNFalpha-mediated cell death. Science 305, 1471–1474 (2004).
Nguyen, J.T. & Wells, J.A. Direct activation of the apoptosis machinery as a mechanism to target cancer cells. Proc. Natl. Acad. Sci. USA 100, 7533–7538 (2003).
Jiang, X. et al. Distinctive roles of PHAP proteins and prothymosin-α in a death regulatory pathway. Science 299, 223–226 (2003).
Boatright, K.M. & Salvesen, G.S. Mechanisms of caspase activation. Curr. Opin. Cell Biol. 15, 725–731 (2003).
Roy, S. et al. Maintenance of caspase-3 proenzyme dormancy by an intrinsic "safety catch" regulatory tripeptide. Proc. Natl. Acad. Sci. USA 98, 6132–6137 (2001).
Nakagawara, A. et al. High levels of expression and nuclear localization of interleukin-1 β converting enzyme (ICE) and CPP32 in favorable human neuroblastomas. Cancer Res. 57, 4578–4584 (1997).
Izban, K.F. et al. Characterization of the interleukin-1β-converting enzyme/Ced-3-family protease, caspase-3/CPP32, in Hodgkin's disease. Am. J. Pathol. 154, 1439–1447 (1999).
Estrov, Z. et al. Caspase 2 and caspase 3 protein levels as predictors of survival in acute myelogenous leukemia. Blood 92, 3090–3097 (1998).
Fink, D. et al. Elevated procaspase levels in human melanoma. Melanoma Res. 11, 385–393 (2001).
Persad, R. et al. Overexpression of caspase-3 in hepatocellular carcinomas. Mod. Pathol. 17, 861–867 (2004).
Svingen, P.A. et al. Components of the cell death machine and drug sensitivity of the National Cancer Institute Cell Line Panel. Clin. Cancer Res. 10, 6807–6820 (2004).
Pop, C., Feeney, B., Tripathy, A. & Clark, A.C. Mutations in the procaspase-3 dimer interface affect the activity of the zymogen. Biochemistry 42, 12311–12320 (2003).
Stennicke, H.R. et al. Pro-caspase-3 is a major physiologic target of caspase-8. J. Biol. Chem. 273, 27084–27090 (1998).
Denault, J.-B. & Salvesen, G.S. Human caspase-7 activity and regulation by its N-terminal peptide. J. Biol. Chem. 278, 34042–34050 (2003).
Putt, K.S., Beilman, G.J. & Hergenrother, P.J. Direct quantitation of poly(ADP-ribose) polymerase (PARP) activity as a means to distinguish necrotic and apoptotic death in cell and tissue samples. ChemBioChem 6, 53–55 (2005).
Liang, Y., Nylander, K.D., Yan, C. & Schor, N.F. Role of caspase 3-dependent Bcl-2 cleavage in potentiation of apoptosis by Bcl-2. Mol. Pharmacol. 61, 142–149 (2002).
Fujita, N., Nagahashi, A., Nagashima, K., Rokudai, S. & Tsuruo, T. Acceleration of apoptotic cell death after the cleavage of Bcl-XL protein by caspase-3-like proteases. Oncogene 17, 1295–1304 (1998).
Earnshaw, W.C., Martins, L.M. & Kaufmann, S.H. Mammalian caspases; structure, activation, substrates, and functions during apoptosis. Annu. Rev. Biochem. 68, 383–424 (1999).
Koty, P.P., Zhang, H. & Levitt, M.L. Antisense bcl-2 treatment increases programmed cell death in non-small cell lung cancer cell lines. Lung Cancer 23, 115–127 (1999).
O'Donovan, N. et al. Caspase 3 in breast cancer. Clin. Cancer Res. 9, 738–742 (2003).
Vakkala, M., Paakko, P. & Soini, Y. Expression of caspases 3, 6 and 8 is increased in parallel with apoptosis and histological aggressiveness of the breast lesion. Br. J. Cancer 81, 592–599 (1999).
Devarajan, E. et al. Down-regulation of caspase 3 in breast cancer: a possible mechanism for chemoresistance. Oncogene 21, 8843–8851 (2002).
This work was supported by the National Science Foundation (NSF CAREER award to P.J.H., CHE-0134779), the University of Illinois (to P.J.H.) and the National Institutes of Health (Grant CA77355 to W.G.H. and AG024387 to W.G.H. and D.R.D.). K.S.P. is supported by a fellowship from the American Chemical Society Division of Medicinal Chemistry. M.S.H. was supported by National Institute of Environmental Health Sciences Training Grant 5T32ES007326-05. J.T.K., S.K.H. and H.J. are recipients of a Brain Korea 21 fellowship. M.H.C. is supported by a Korea Science and Engineering Foundations (KOSEF), Ministry of Science and Technology (MOST) grant (550-20060062). We thank P. Tender and L. Tangen (Carle Foundation Hospital) for the primary colon cancer samples. We thank R. Hoffman (University of Illinois-Chicago Cancer Center) for the generous gift of human bone marrow. We thank G. Salvesen (Burnham Institute) for the gift of the procaspase-3 and procaspase-7 expression vectors. We thank D. Goode and A. Sharma (University of Illinois) for synthesis of the peptidic caspase substrate. We acknowledge the assistance of the Flow Cytometry Facility of the Biotechnology Center at the University of Illinois.
Department of Biochemistry, University of Illinois, Urbana, 61801, Illinois, USA
Karson S Putt & Paul J Hergenrother
Department of Chemistry, University of Illinois, Urbana, 61801, Illinois, USA
Grace W Chen, Jennifer M Pearson, Joseph S Sandhorst & Paul J Hergenrother
Department of Food Science and Human Nutrition, University of Illinois, Urbana, 61801, Illinois, USA
Martin S Hoagland & William G Helferich
Laboratory of Toxicology, College of Veterinary Medicine and Nano Systems Institute-National Core Research Center (NSI-NCRC), Seoul National University, Seoul, 151-742, South Korea
Jung-Taek Kwon, Soon-Kyung Hwang, Hua Jin & Myung-Haing Cho
US Food and Drug Administration, National Center for Toxicological Research, Jefferson, 72029, Arkansas, USA
Mona I Churchwell & Daniel R Doerge
Karson S Putt
Grace W Chen
Jennifer M Pearson
Joseph S Sandhorst
Martin S Hoagland
Jung-Taek Kwon
Soon-Kyung Hwang
Hua Jin
Mona I Churchwell
Myung-Haing Cho
Daniel R Doerge
William G Helferich
Paul J Hergenrother
K.S.P. and P.J.H. were responsible for designing the experiments and writing the manuscript. K.S.P. conducted the high-throughput screen, all in vitro and all cell culture experiments with PAC-1, and all experiments with the primary colon tumors. G.W.C. and J.M.P. assisted with the high-throughput screen. J.S.S. was responsible for the synthesis of PAC-1 and its derivatives. M.S.H. and W.G.H. evaluated PAC-1 in the ACHN xenograft model. J.T.K., S.K.H., H.J. and M.H.C. evaluated PAC-1 in the NCI-H226 xenograft models. D.R.D. and M.I.C. determined the concentrations of PAC-1 in mouse serum.
Correspondence to Paul J Hergenrother.
The authors declare no competing financial interests.
Supplementary Fig. 1
Western blot showing PAC-1 efficacy at 5 μM. (PDF 66 kb)
Flow cytometry data showing PAC-1 efficacy at 5 μM. (PDF 75 kb)
Graph showing that Z-VAD-FMK inhibits cell death induced by PAC-1. (PDF 22 kb)
Graph showing that PAC-1 does not inhibit PARP-1. (PDF 19 kb)
Graph showing etoposide-induced cell death does not correlate with cellular procaspase-3 concentrations. (PDF 20 kb)
Primary data showing procaspase-3 concentrations in cancerous and noncancerous colon tissue taken from 23 people. (PDF 312 kb)
Graph showing the concentration of PAC-1 in serum. (PDF 19 kb)
Supplementary Methods
All chemical and biological protocols. (PDF 202 kb)
Putt, K., Chen, G., Pearson, J. et al. Small-molecule activation of procaspase-3 to caspase-3 as a personalized anticancer strategy. Nat Chem Biol 2, 543–550 (2006). https://doi.org/10.1038/nchembio814
Accepted: 27 July 2006
Issue Date: October 2006
DOI: https://doi.org/10.1038/nchembio814
Induction of apoptosis in breast cancer cells by naphthylisoquinoline alkaloids
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In an era of less seems best and minimalism in the home, it's often nice to look back to when things were a little more lavish, a little softer and perhaps, a little warmer to the eye.
At The Roman Empire, we are proud to offer an array of custom made curtain styles such as pinch pleat, pencil pleat, gathered and the popular S-fold to fill that void, with all of our drapery manufactured using only the best fabrics and linings.
With many stunning fabrics on show, we are sure that we can not only create a visual masterpiece for your home, but we can do it to your budget.


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News, stories, and updates from Hillel communities worldwide
Anne Frank tree takes root at University of Iowa
A piece of Jewish history has been uprooted from Amsterdam and planted in Iowa City. One sapling grown from an old chestnut tree — which stood outside of the secret annex where Anne Frank wrote her famous diary — was planted at University of Iowa.
Discover the Crew that's Right for You
Search colleges and universities for all kinds of Jewish experiences

redpajama_set_name: RedPajamaCommonCrawl


Meticulously crafted, each Grizas dress from the Grizas womenswear collection displays contemporary and effortless design. A stand out label in our selection of dresses the collection features silk dresses complete with the label's signature crinkle effect and lightweight breathable linen dresses to create a stunning drape. The voluminous shapes and cuts allow for an offbeat layered look, explore our selection of Grizas skirts, tops and knitwear to discover new outfits for this season.


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Q: Accessing Video Content ONLY through an iOS App - How would I do that I've got a client that wants to have a paid app providing his video instructional content on iOS, but of course we dont want people simply getting the video content directly without paying for the app.
Is there some simple way of doing this that I'm overlooking? He wants the content streamed so he can add content easily and periodically without app updates.
Perhaps using Youtube but having the videos password protected? Is there a service anyone has used with an appropriate iOS API that anyone has heard of?

A: I've never done this before, but you could do some kind of token exchange based on the device ID. When the app is first used, register the device ID with the content server, and use that in combination with a salted hash of some kind to identify the device when requesting the media from the server.

A: I'm considering two options right now.
1- Following this post (roughly) In iOS, how would you programmatically pass a username / password to a secure site and essentially doing a combination of .htaccess for password protection,  leveraging robots.txt to prevent search engines from indexing the videos, and obfuscating the video names. I've got to research the password protection of the video directory and how exactly to do that... but it seems the simplest. The downside is the clear text password.
2- A slightly more sophisticated method where I use oAuth to authenticate against but really following the first path, and  potentially leveraging http://maniacdev.com/2010/09/new-open-source-oauth-library-for-easy-authentication-on-ios-devices-from-google/  to help in writing the oAuth piece.
a third possibly prohibitively expensive option is to look at the HTTP live streaming in OSX server https://developer.apple.com/streaming/
How do you guys think these options sound? Are there others I'm not considering?

redpajama_set_name: RedPajamaStackExchange


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Sony Xperia Sola – Newest Xperia Family Member
Voltage drop or'volt drop' happens in all types of electrical installations. When bigger power cables are being set up more intricate calculations must be made to counteract the problem. But when LED strips or tapes are concerned there are a couple of simple guidelines to follow.
For any best led strip lights sync with music strips over 2 metres in length it's possible to provide a 12volt feed to both ends of this strip or one feed in the center, by cutting the strip into two and connecting the power supply to both strips. This provides a more even power distribution and should offer a more consistent lighting.
It wasn't until 1910 that in Paris a, man called Georges Claude came up with the idea for neon signs. His first effort was a sign for a barber shop in that city. How and when did they first come to the United States. Earle Anthony, the owner of an auto dealership in Los Angeles, apparently heard about neon signs and visited Paris. The end result was two Packard neon signs which he purchased for $1,250. The year was 1923. The idea spread quickly because both businesses and the public took hold of this new concept in advertising. Traditional sign advertising was hit with the brilliant explosion of neon signs. These initial signs were called"liquid fire" no doubt due to the bright red light they emitted seem to signify danger.
What is Vegas without some magic? In 1973, Illusionists Sigfried and Roy started their famous white tigers and lions shows. These shows were a massive success and placed these 2 gentlemen in the group of Legends of Las Vegas. This was also a bad time for Vegas because it had been struck by a flash flood that resulted in damages amounting to over $1 million. On top of that another American town, Atlantic City, legalized gambling which diverted tourists away from Las Vegas.
Beam Lights. The Beam Light is a bit different as each of the optics are contained in the bulb. This approach brings the cost of the fixture down although the lamps are a bit more expensive. The most commercial electric led tape light typical tyoe of the fixture are the Parcan. Such lamps deliver a very intensive beam of light which can be particularly effective except that there is no control with the beam therefore the spread is a touch uneven. Used widely in Rock'n'Roll due to the intensity of the light which works nicely along with strong colors.
As soon as you have decorated the walls and the structure of the venue you then need to begin looking at the furniture at the venue. You will likely want it to match the rest of the venue and it will make the venue look much better. Most companies that do provide venue dressing are likely to groom the furniture but you can do it yourself. All you need is a substance like the stuff use on the walls and then drape it on the seats and then tie it back.
Turning our attention from both of these neon showcases there are other areas in the Us that have noteworthy neon signs. However, they're naturally not on exactly the exact same level as the previously mentioned giants of neon signage. In Elk City, Oklahoma at the National Route 66 Museum proudly displays the giant iconic Route 66 neon sign. The town of Saginaw, Michigan asserts it's the largest neon sign in the state an d the biggest figural sign in the nation. Figural neon signs show people and animals. This neon sign is 35 feet high and fifty feet long.
So how do we make a great such light? We utilize SMD led as the light source, which usually be SMD5050 and SMD3528 Led. SMD5050 and SMD3528 are also the primary light source of LED strip lighting.
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Kate Henshaw, Juliet Ibrahim, others discussed the growth of Nollywood at community meeting
The second edition of the Vibe.NG forum, Community meeting with Nollywood, with the theme, From Script to Screen and Everything in-between, held at the Didi Art Museum, Lagos.
The panelists consisted of veterans and new age entertainers, who came together to discuss the Nigerian movie industry.
Adunni Ade took centre stage as the panel moderator; she asked questions ranging from classic Nollywood to the new Nollywood.
Veteran actress and movie producer, Kate Henshaw talked about how the industry has grown from the early stages to the new age Nollywood; how distribution and piracy is still a major problem; how social media is a very effective tool for marketing in this new age and era, and how good content is what will keep impacting the society.
She also spoke on new opportunities available in the Nigerian movie industry.
Movie Producer, Jade Osiberu, who recently produced Isoken: The Movie, spoke on her effective marketing strategies for her latest project, using social media and the internet by extension. She highlighted the benefits of investing in the film industry, noting that investment was still a major challenge. She also gave some key points on why some movies were more profitable to make than others.
Movie producer and actress, Juliet Ibrahim spoke on the challenges of distribution and its consequences on profit, noting that foreign movies were given priority in Nigeria and therefore, limited the growth of the Nigerian movie industry.
Actor Deyemi Okanlawon suggested that the focus should be on movies that positively affect the Nigerian society, stating that there should be better marketing structures, business models and ventures for the Nigerian movie industry.
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A DEITY whose life might in a sense be said to be neither in heaven nor on earth but between the two, was the Norse Balder, the good and beautiful god, the son of the great god Odin, and himself the wisest, mildest, best beloved of all the immortals. The story of his death, as it is told in the younger or prose Edda, runs thus. Once on a time Balder dreamed heavy dreams which seemed to forebode his death. Thereupon the gods held a council and resolved to make him secure against every danger. So the goddess Frigg took an oath from fire and water, iron and all metals, stones and earth, from trees, sicknesses and poisons, and from all four-footed beasts, birds, and creeping things, that they would not hurt Balder. When this was done Balder was deemed invulnerable; so the gods amused themselves by setting him in their midst, while some shot at him, others hewed at him, and others threw stones at him. But whatever they did, nothing could hurt him; and at this they were all glad.
Only Loki, the mischief-maker, was displeased, and he went in the guise of an old woman to Frigg, who told him that the weapons of the gods could not wound Balder, since she had made them all swear not to hurt him. Then Loki asked, "Have all things sworn to spare Balder?" She answered, "East of Walhalla grows a plant called mistletoe; it seemed to me too young to swear." So Loki went and pulled the mistletoe and took it to the assembly of the gods. There he found the blind god Hother standing at the outside of the circle. Loki asked him, "Why do you not shoot at Balder?" Hother answered, "Because I do not see where he stands; besides I have no weapon." Then said Loki, "Do like the rest and show Balder honour, as they all do. I will show you where he stands, and do you shoot at him with this twig." Hother took the mistletoe and threw it at Balder, as Loki directed him. The mistletoe struck Balder and pierced him through and through, and he fell down dead. And that was the greatest misfortune that ever befell gods and men. For a while the gods stood speechless, then they lifted up their voices and wept bitterly. They took Balder's body and brought it to the sea-shore. There stood Balder's ship; it was called Ringhorn, and was the hugest of all ships. The gods wished to launch the ship and to burn Balder's body on it, but the ship would not stir. So they sent for a giantess called Hyrrockin. She came riding on a wolf and gave the ship such a push that fire flashed from the rollers and all the earth shook. Then Balder's body was taken and placed on the funeral pile upon his ship. When his wife Nanna saw that, her heart burst for sorrow and she died. So she was laid on the funeral pile with her husband, and fire was put to it. Balder's horse, too, with all its trappings, was burned on the pile.
Whether he was a real or merely a mythical personage, Balder was worshipped in Norway. On one of the bays of the beautiful Sogne Fiord, which penetrates far into the depths of the solemn Norwegian mountains, with their sombre pine-forests and their lofty cascades dissolving into spray before they reach the dark water of the fiord far below, Balder had a great sanctuary. It was called Balder's Grove. A palisade enclosed the hallowed ground, and within it stood a spacious temple with the images of many gods, but none of them was worshipped with such devotion as Balder. So great was the awe with which the heathen regarded the place that no man might harm another there, nor steal his cattle, nor defile himself with women. But women cared for the images of the gods in the temple; they warmed them at the fire, anointed them with oil, and dried them with cloths.
Whatever may be thought of an historical kernel underlying a mythical husk in the legend of Balder, the details of the story suggest that it belongs to that class of myths which have been dramatised an ritual, or, to put it otherwise, which have been performed as magical ceremonies for the sake of producing those natural effects which they describe in figurative language. A myth is never so graphic and precise in its details as when it is, so to speak, the book of the words which are spoken and acted by the performers of the sacred rite. That the Norse story of Balder was a myth of this sort will become probable if we can prove that ceremonies resembling the incidents in the tale have been performed by Norsemen and other European peoples. Now the main incidents in the tale are two—first, the pulling of the mistletoe, and second, the death and burning of the god; and both of them may perhaps be found to have had their counterparts in yearly rites observed, whether separately or conjointly, by people in various parts of Europe. These rites will be described and discussed in the following chapters. We shall begin with the annual festivals of fire and shall reserve the pulling of the mistletoe for consideration later on.
When you see those Aryanized images of "Jesus" what you are really seeing is Balder surviving as a folk memory.


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If You Haven't Researched Arguments Disputing A Western Narrative, You Don't Understand The Issue
Lately when people react with shock and indignation that I would dare to dispute a claim made by the western political/media class about an empire-targeted government, I've taken to simply asking them what reading they've done on the other side of the issue. What are some articles they've read arguing against the official western narrative about that government?
It's a question that can be applied to any disputed western narrative about any government the US-centralized empire doesn't like. Russia is engaging in aggressive provocations. Assad is using chemical weapons. There's a genocide in Xinjiang. Iran is developing nuclear weapons. Maduro is deliberately starving his people. Whatever's the Official Imperial Line of the Day about the Official Bad Guy of the Day.
What I've found interesting about this exercise is that while I would've correctly predicted that those questioned had done zero research into the opposing viewpoints of the issue they're commenting on, I would probably not have predicted the brazenness with which they'll admit it. Very often they'll come right out and express incredulity at the very idea that any such counter-arguments could even exist, skipping right past any pretense that they may have read them or even made any effort to find them.
When they do this, even before I provide them with links to counter-arguments against whatever issue we're discussing, they have already lost the argument. They have already admitted that they've done no real research into whether or not the western narrative they just swallowed is actually true; they just believed what they were told because someone told them to believe it. They swallowed an imperial narrative about an empire-targeted government with zero gag reflex, just as people did in the lead-up to the Iraq war.
At that point it's been established that, at least as far as the subject under discussion goes, they are no better informed than any average consumer of TV news. Because they have made no effort to find and review arguments and evidence that go against the TV news narrative.
There are always counter-arguments against western criticisms of empire-targeted governments. They are not difficult to find once you've decided you want to find them, as long as you're open to venturing outside your own self-reinforcing echo chamber. They're not always great arguments. They don't always leave the empire-targeted government in question looking perfectly innocent. And they generally won't be found in The New York Times, The Wall Street Journal, or any other western outlet which consistently protects and promotes western imperialist narratives. But they are there, and unless you have reviewed their arguments and evidence and given them a good deal of consideration, you're in no position to pretend you know anything about the subject under discussion.
This same principle applies to "conspiracy theories" as well, both for and against. If you haven't reviewed the evidence for and against a given theory, then unless it's something that's self-evidently absurd at a casual glance it would be silly and asinine for you to take a confident position on it one way or the other. This also applies to arguments for and against measures that have been implemented and could potentially be implemented in response to Covid-19.
If you haven't thoroughly researched the opposite position, you don't understand your own. This is true whether you agree with the official narrative or disagree with it. Oftentimes people of a certain bent will be biased against the mainstream narrative and select for arguments against it which confirm that bias, even when the mainstream narrative is the better-evidenced one. It cuts both ways.
It's very easy to select a position on an issue which conforms to your ideological preferences and your understanding of the world. It's much harder to sincerely dedicate yourself to finding out whether or not something is true, or whether the truth of the matter is a lot less certain than the talking heads in the western news media are making it seem. But it's the only way you can really have a legitimate position on such matters.
This should be a widespread and common sense understanding, and it is to everyone's detriment everywhere that it isn't.
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Zain Ibraheem
Embracing the Real enemy
Bernie Sanders: Marxist or Democratic Socialist?


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Q: Ampscript fallback content for country Canada I have a code in the header which is supposed to give you a fall back content block if the country isn't any of those listed, in this case Canada which has French and English as language.
In the content area of the email which shows content I have a code which pulls a content block that should show for all countries but Canada.
I get an error message saying that it can't find the path for the content block in FR. So it's looking for the block rather than giving it the fallback I specified in the header.
Code in header:


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Actresses / Interviews / Online / Pop Culture / Reality Television / Television
The Merrell Twins – Living in Awesomeness
Posted on February 26, 2020 by popenterta	Leave a comment
Vanessa and Veronica Merrell
The Merrell Twins
Living in Awesomeness
by Kayla Marra
Identical twins and YouTube stars Vanessa and Veronica Merrell have been taking the internet by storm since they began creating videos in 2009. The twins grew up in Kansas City, Missouri and later moved to Los Angeles in 2013 to pursue their YouTube and acting careers. Over the years, Vanessa and Veronica have gained an impressive following of 5.1 million devotees on their YouTube channel "MerrellTwins." Other than gaining huge amounts of dedicated fans, the twins have earned themselves Streamy, Shorty, Cynopsis, and Kids' Choice awards and nominations.
In 2019, the girls teamed up with widely popular AwesomenessTV YouTube channel to star in and produce their very own show Twin My Heart. The YouTube series follows Vanessa and Veronica as they invite seven guys to compete in challenges set up by the twins to see who can win Vanessa's heart. The first season of the show garnered a total of 14.6 million views, which was a surprise to the twins when I shared that stat with them. With the release of the first episode of season two, also on AwesomenessTV, I was able to chat with the girls about everything from their series, to working with AwesomenessTV, and some exciting things for fans to look forward to in the future.
Hi! I'm Kayla with Pop Entertainment and we are so happy to talk with you girls! First and foremost, could you introduce yourselves?
Vanessa Merrell: Hi, I'm Vanessa Merrell.
Veronica Merrell: And I'm Veronica Merrell.
Both: (laughing) We're the Merrell Twins!
Congratulations on your Streamy, Shorty, and Cynopsis Award wins and nominations! What was going through your heads when you ladies got the news that you had won your first Shorty award for "YouNower of the Year" in 2016?
Veronica Merrell: Oh, wow! You're pulling on memories really far in my brain! It was a really awesome, amazing time. It was the first ever award for live streaming, and so the fact that my sister and I won that award, we were very honored. It was a crazy time.
Yeah, that's super crazy and amazing. The Kids' Choice Awards are coming up and you two are nominated, congratulations on that, as well! What does getting nominated for a Kids' Choice Award mean for you ladies, and who and what are you looking forward to seeing at the awards?
Vanessa Merrell: Being nominated for a Kids' Choice Award is absolutely a really big honor. We've been nominated for Teen Choice Awards, but we've never been nominated for a Kids' Choice Award. I guess it just really shows the big impact we have through our channel. We love kids. We love that demographic. We really hope that we're being inspirations to many kids around the world. It's just a really big honor to be nominated. I really can't wait to go to The Kids' Choice Awards. I'm hoping to see the cast of the High School Musical: The Musical: The Series, because I think some of the guys are cute! That's what I'm looking forward to seeing!
Veronica Merrell: We've grown up watching The Kids' Choice Awards, so just to be nominated, like Nessa said, is an amazing honor. I'm looking forward to seeing which celebrities are there and hopefully we might get slimed!
That's the goal!
Veronica Merrell: (laughs) Yes, that's the goal!
In 2019 you worked with AwesomenessTV and released the first season of Twin My Heart. In season one, Veronica, you tried to find a boy for Vanessa through games and challenges. So, could you ladies explain what that whole experience was like on either end?
Veronica Merrell: We've always loved working with AwesomenessTV. They have been such a huge part of our growth on YouTube. The family that is over there, we really enjoy it. There is nothing like it. When we went to AwesomenessTV to pitch the idea for Twin My Heart, we had the idea for a dating show for a long time. We just didn't know which direction to take it in. Nessa and I came up with the Twin My Heart idea where I find my sister a boyfriend, or someone to love. AwesomenessTV is the first place we thought of. We could have done it on our channel, but I don't think we could have done it without the team that AwesomenessTV has. They were so helpful, and the collaborative process was amazing.
Vanessa Merrell: Adding on to what my sister just said, it was absolutely a crazy experience. It's like the weirdest, craziest way to find love. We had a week, and ten boys going after you! I can't even explain it, because I know a lot of people have not experienced this before – very few people have experienced a dating show. It was dramatic, it was stressful, it was fun, exciting, I've never felt that many emotions that fast in a week.
Veronica Merrell: Since we are executive producers, I got to help choose what was going on throughout the episodes and help test the guys. It's very different compared to what we do on our normal channel, where we both write sketches and it's not so much reality. It was very awesome to experience what reality TV is like.
Yeah, I bet! This is a question for both of you: what has it been like working with your twin sister and have so much success with it?
Vanessa Merrell: Working with my twin has been an incredible journey. We've been best friends since we were kids. If you would have told me when we were five years old that we would be working together, making videos, and doing fun skits I would have been like, "What? That's crazy!" I would have been so excited just because we are so close, and we are best friends. It's like a dream job. Honestly in the last few years I have seriously considered YouTube as a job because it's so much fun, especially because we work together, and our parents are involved. Our dad, Paul Merrell, he produces and edits our videos. Our mom, she's like our personal assistant and helps us run our emails and all that stuff. She helps us stay organized. Without her we wouldn't be anything. It's a really cool family thing that we have going on. I wouldn't trade it for anything in the world. We just have so much fun and we laugh pretty much all the time. It's just a crazy thing we've got going on.
Veronica Merrell: I don't know how I can top that answer, but ya know! It's really fun working with your siblings and your family. Some people might see it as a bad thing, but it's really what you make of it, to be honest. I love doing what we do, and I would have never dreamed of it.
I'm an only child so that sounds amazing! Season one of Twin My Heart has gained a total of 14.6 million views, which is insane, congratulations on that!
Both: Wow, thank you!
Veronica Merrell: I didn't even know that!
Did you ladies have a favorite episode, favorite challenge, or favorite date from season one?
Vanessa Merrell: I think my favorite date I went on was with Christian at the Cat Cafe. That was my favorite date!
That was so cute. I watched the show and I was like wow, that's some cute stuff right there.
Veronica Merrell: I think one of my favorite episodes, even though I hated the challenge, it was the twin-swap challenge, where we switched on the guys. Nessa and I have always been that type of twins to not really switch on people. We don't really prank people with our looks, because we're identical, but this is the first time we had ever done that. I was so nervous, but the outcome was so funny to see who would be able to tell us apart and if they could tell the difference.
Vanessa and Veronica Merrell with Nezza and Franny
In season two, you are working with Nezza and Franny Arietta. What has it been like working with them and what can we look forward to in the upcoming season?
Vanessa Merrell: Franny and Nezza are two of our best friends. We thought it would be perfect for us to help them find love. I think the thing that you can look forward to the most is that there's going to be a lot more drama. There's a lot more drama this season and a lot more challenges.
Veronica Merrell: For season one, we're best friends and we get along. We're sisters, at the end of the day we have to be kind to each other because the next day we're seeing each other and we're living with each other. When you add two other girls to the mix, things do get very crazy and dramatic and sometimes you can't overstep boundaries and things like that. The upcoming season of Twin My Heart is very dramatic, and I think there is a big lesson that people can take from it, and it's a positive lesson. That's something to look forward to.
I can't wait to see how season two plays out! Before the release of Twin My Heart in 2019, you launched your clothing line True IMG in 2018. Could you tell us a bit about your line, and can we expect some new pieces in the future?
Veronica Merrell: We started our clothing line called True IMG and it was so much fun. It's a passion for us. As YouTubers, we can pretty much do whatever we want when we set our minds to something. If we want to do this and that, we can. Right now, we're just fixing up holes in our clothing line. We'll have a meeting about it this year and see if we can come up with bigger stuff and things we want to do – maybe jewelry, shoes, more stuff like that. It's still in the talks. Right now, we're focusing on merch, too. It gets confusing when you're promoting so much stuff to your audience!
For sure! Since you're already acting and doing some clothing design, what other career path are you interested in trying in the future?
Veronica Merrell: Nessa and I have been working to really get our production company going. We would really love to create a movie in the future. Right now, we are working on a series on our channel with a production company. All of our videos are technically produced by our production company, but in this series, we are bringing a bunch of crew and props people, we're getting producers, it's a big set! That's what we would like to try and do more of in the future. Focus on making more series and more production, maybe a movie or TV show. It's kind of hard to go to production companies and networks to pitch yourself because sometimes they don't see your ideas – so why not create them yourself?
Vanessa Merrell: I think that's what I want to do, too! We're really excited for our series coming up. I think this year and, in the future,, I want to focus on making more music for me and my sister and focus on acting, as well, along with making YouTube videos every week. We have some big plans for the future.
Veronica Merrell: An example of what we've been doing with our production company is the collaboration with AwesomenessTV, that was such a dream collaboration. They understand our ideas and they get the platform. It was just the perfect way to get our foot in the door with the production company.
Your YouTube channel is very popular. Who comes up with the ideas and what is your creative process like?
Vanessa Merrell: Basically, it's a team effort when it comes to creating ideas. Either Ronnie will think of an idea and be like, "Hey! Let's create a skit around this subject!" and we'll collaborate together. Or maybe one of us comes up with an entire idea and the other one puts in their ideas here and there. For the most part, it's really a team effort. Sometimes our dad pitches in ideas, sometimes they're good and sometimes they're "eh." It is a family effort. We're always looking at what's trending and what's popular. That's how we come up with our parodies sometimes. We take songs and we turn them into silly things.
Veronica Merrell: An example of how our creative process works – we were watching A Double Shot at Love on MTV and we were like "Oh my gosh! What if we did a show like this but on YouTube, for you, Nessa!" So, a month later we came up with the pitch and went to AwesomenessTV and that's how that idea happened. It's literally as little as watching something on TV and going "Oh my gosh, what if we did that?" or looking at the trends as they happen.
Who would you say inspires you ladies the most – whether it be in your personal life, other YouTubers, celebrities?
Vanessa Merrell: There are so many people that inspire us, it's so hard to pick just one person. I believe that we should have a lot of inspirations in life because everyone has different ways they go about their lifestyle. It's always really nice to look and see how people are doing their own thing and get inspiration from that. For the most part, there's so many YouTubers that we look up to, like Liza Koshy, Ryan Higa, Rhett and Link. Mr. Beast is a huge inspiration to watch, too. When it comes to our personal lives, I think our parents really inspire us to be the best people we can be. When it comes to acting and music there's so many other people we love. Meryl Streep, Emma Stone, Vanessa Hudgens has always been a big inspiration, Audrey Hepburn has been a big inspiration, too. The way they live their lives in their career. We're inspired by a lot of people.
That's a very good thing. Could you tell us something about you that even your biggest fans wouldn't know – whether it be a special talent or anything?
Vanessa Merrell: It's kind of crazy because being a YouTuber you put a lot of yourself out there. Especially because we live stream every week, we talk about our lives a lot. It's hard to think of something that our fans don't know about us because they know quite a bit!
Veronica Merrell: Well, Nessa has been learning to produce her own music. Some of our fans know that, only the ones that watch the live stream.
Vanessa Merrell: Thank you! I think something a lot of people don't know about Veronica is that she can crochet! (Both laugh)
Veronica Merrell: My fact about you was so much cooler than that!
Vanessa Merrell: Another fact that people don't know about Veronica is that she is a really, really good writer. She writes amazing poems and lyrics. She is the main writer for our skits and stuff.
Veronica Merrell: Crocheting has been a very neat skillset to have.
It's a useful one! Did you ladies have a message you'd like to say to your fans?
Veronica Merrell: A message I would like to send to our fans, or anyone who is reading this, is just to not give up. Life can be so hard and there's so many things that are sad and depressing in this world. The big thing we can all do is to not give up, try to stay inspired, love everyone and be kind.
Vanessa Merrell: I think the quote "never give up" is kind of cheesy sometimes, but when you actually think about it and not give up, it's more about the payoff in the future rather than the now. When you don't give up and when you look down the road – two, three years from now – and you think "Wow, the fact that I didn't give up on this situation makes me really proud of myself." That's what not giving up is all about, being able to overcome something and looking back and being proud of yourself. Whether it's something as simple as losing or continuing a friendship, or the really big things in life that happen, just always stay positive so in the future you can be proud of yourself and look back and say "I did that and overcame it."
It was awesome getting to chat with Veronica and Vanessa! Be sure to check out season two of Twin My Heart on AwesomenessTV on YouTube, out now!
Copyright ©2020 PopEntertainment.com. All rights reserved. Posted: February 26, 2020.
Photos © 2020. Courtesy of AwesomenessTV. All rights reserved.
Tags: AwesomenessTV, Cynopsis Awards, Franny Arietta, High School Musical: The Musical: The Series, Kayla Marra, Kids' Choice Awards, MerrellTwins, Nezza, Paul Merrell, Shorty Awards, Streamy Awards, Teen Choice Awards, The Merrell Twins, True IMG, Twin My Heart, Vanessa and Veronica Merrell, Vanessa Merrell, Veronica Merrell, YouNower of the Year, youtube. Bookmark the permalink.
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This Small Town in Maine Is Getting a Beautiful New Hotel As Part of a $200-million Revitalization Effort
The revitalization in Waterville, Maine, is a collaboration between Colby College, city leaders, local businesses, and community organizations.
Kristine Hansen
Kristine Hansen is a design, food and drink, and travel writer based in Milwaukee, Wisconsin. She often seeks out wine bars, coffee roasters, cheesemongers' shops, art museums, antiques and vintage stores, yarn shops, and sprawling parks when she travels.
Photo: Courtesy of Lockwood Hotel
College towns often bustle with vibrant arts-and-culture opportunities, a walkable downtown, cute boutique hotels, and an array of restaurants. A $200-million revitalization project — combining public and private investments — aims to transform a historic milling town in Maine to a hip college town rich in arts programming. The initiative includes the debut of a 53-room hotel in August.
Home to Colby College, a liberal-arts institution (and a "little ivy") founded in 1813, Waterville is a town of 16,623 residents. This town's makeover is a collaboration between Colby College, city leaders, local businesses, and community organizations. It aims to boost local economic growth. Colby College's contribution is currently at $85 million.
Named for the former Lockwood textile-mill complex nearby, Lockwood Hotel opens for reservations in August. Front & Main, its on-site restaurant, is already open. Sourcing from both nearby farms and fishermen, the menu hones in on hyper-local seafood specialties like raw oysters, Bay of Fundy salmon and lobster (dishes such as bucatini for dinner or frittata for brunch). It's open for lunch (Wednesday-Friday) and dinner (daily except for Tuesday) as well as Saturday and Sunday brunch. Located on a site that used to be a hotel (the former Crescent Hotel, which opened in 1880), Lockwood Hotel's arrival comes full circle.
Courtesy of Lockwood Hotel
Rooms feature a view of either the Kennebec River or Main Street, and hang-out spots include a terraced patio. Art on exhibit throughout the property is curated by the Colby College Museum of Art. The hotel is also pet-friendly and LEED Silver-certified for its eco-friendly construction.
In addition to the hotel, Colby College spearheaded the arrival of other downtown amenities and attractions, including Bill & Joan Alfond Main Street Commons (student housing open since 2018), Greene Block Studios (arts collaborative directly across from the hotel open since last fall), and the forthcoming $18-million Paul J. Schupf Art Center, a hub for film, arts education, and the performing and visual arts. An opera house is also downtown. By creating places for locals and those affiliated with the college to enjoy and appreciate art, this initiative aims to improve quality of life downtown, while also transforming the city into an arts and culture destination.
In 2014, Colby College president David Greene noted the contrast between what a college town ought to be (vibrant and enticing) and what Waterville actually was (the last mill closed in 2002, leading to a declining population), kickstarting the transformation. In the not-so-distant past, locals can recall boarded-up storefronts and not many reasons to head to downtown Waterville, which is quite the contrast from today when construction activity and places to meet up with friends are in abundance.
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In 1991, the Alaska Center for the Performing Arts and the Anchorage School District were chosen to participate in the first Partners in Education Institute at the John F. Kennedy Center for the Performing Arts. Anchorage-area teachers from all grade levels attended performances, lectures and participatory workshops as part of the Partners in Education program. April 11, 2016 concluded the last Partners in Education workshop at the Alaska Center for the Performing Arts, spanning 25 years.
While there are no plans to continue the Partners in Education Program at the Alaska Center for the Performing Arts, the impacts of the collaborative process between artists and local educators will reverberate for years to come.


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"""matchmaker URL Configuration

The `urlpatterns` list routes URLs to views. For more information please see:
    https://docs.djangoproject.com/en/1.11/topics/http/urls/
Examples:
Function views
    1. Add an import:  from my_app import views
    2. Add a URL to urlpatterns:  url(r'^$', views.home, name='home')
Class-based views
    1. Add an import:  from other_app.views import Home
    2. Add a URL to urlpatterns:  url(r'^$', Home.as_view(), name='home')
Including another URLconf
    1. Import the include() function: from django.conf.urls import url, include
    2. Add a URL to urlpatterns:  url(r'^blog/', include('blog.urls'))
"""
from django.conf.urls import url, include
from django.contrib import admin
from django.conf import settings
from django.conf.urls.static import static

from home.views import HomeView

urlpatterns = [
    url(r'^admin/', admin.site.urls),
    url(r'^$', HomeView.as_view(), name='home'),
    url(r'^accounts/', include('accounts.urls')),
    url(r'^profile/', include('profiles.urls')),
    url(r'^questions/', include('questions.urls')),
    url(r'^dashboard/', include('dashboards.urls')),
]

if settings.DEBUG is True:
    urlpatterns += static(settings.MEDIA_URL, document_root=settings.MEDIA_ROOT)

redpajama_set_name: RedPajamaGithub


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Imran To US Senators: No Talks With India
Press Trust of India | October 8, 2019
Pak PM Imran Khan in a meeting with the visiting US senators. — (Photo: PTI Official Twitter)
ISLAMABAD – Pakistan Prime Minister Imran Khan told a visiting US Congressional delegation on Monday that talks with India were out of question in view of the situation in Kashmir after India revoked Jammu and Kashmir's special status.
Khan said there would be no talks with India during a meeting with US senators Chris Van Hollen and Maggi Hassan, who met to share their observations with the prime minister about their visit to Pakistan-administered Kashmir on Sunday, Geo News reported.
Khan said he was the biggest supporter of Pakistan-India talks; however, it is impossible until the situation is changed for the better in Kashmir.
Khan also thanked the US senators for cooperation on the issue of Kashmir.
Hollen is part of a group of US senators who have expressed concern over the human rights situation in Kashmir, the report said.
US Congress members Tahir Javed and US charge d affairs Paul Jones were also a part of the delegation that met Khan, the report said.
The US delegation also met Pakistan Army chief General Qamar Bajwa at the General Headquarters, said a statement by Inter-Services Public Relations (ISPR), the military's media wing.
The Afghan reconciliation process, as well as issues of mutual interest and overall regional security were discussed with the visiting dignitaries.
https://kashmirobserver.net/2019/10/08/imran-to-us-senators-no-talks-with-india
Bajwa appreciated Washington's understanding and support on resolving the Kashmir issue, as well as, Pakistan's efforts in Afghanistan, The Express Tribune reported.
Both the sides stressed upon importance of strong bilateral relationship between the US and Pakistan in and beyond security cooperation, the report said.
In his maiden speech at the UN General Assembly last month, Khan raised the Kashmir issue and demanded that India must lift the "inhuman curfew" in Kashmir and release all "political prisoners".
Khan devoted half of his address to the Kashmir issue, warning that if there's face-off between two nuclear-armed neighbours, the consequences would be far beyond their borders.
India has been maintaining that the Kashmir issue is a bilateral matter between India and Pakistan and there is no scope for third-party mediation.
Ties between India and Pakistan came under severe strain after New Delhi's decision to revoke Jammu and Kashmir's special status on August 5. Pakistan reacted angrily to the move and expelled the Indian envoy. Since then, Pakistan has been trying to rally international support against India on the issue.


CCD stands for Confraternity of Christian Doctrine. A "CCD" was established in 1562 at Rome to help with the education of Catholics in the faith. In modern times, it has come to mean a program of Catholic education for all parish children.
• To proclaim the Good News of Jesus Christ and encourage students to come to know him and love him personally as they come to know the Church he established.
 • To develop an understanding in our students of what it means to be an intentional disciple of Jesus and then striving to constantly discern and follow the Father's will for their lives.
• To foster reverence for the Church and our Catholic faith.
CCD meets from 10:10-11:05 on Sunday mornings during the school year. See schedule for dates.
To Register for CCD- please utilize the Registration form under "documents" on your left.
At the Cathedral of Christ the King, we recognize and affirm the uniqueness of each individual person. In doing so, we open our doors to the learner with special needs working in partnership with the learners' families to incorporate them into the Body of Christ through parish religious education, sacramental preparation, and all church activities for children. We strive to make our religious education programs accessible and appropriate to all persons and to address the individual and special needs of our children.
Parents of children with a special need should contact Karen Kirkland, Coordinator of Children's Catechesis, to discuss the particular need so that accommodations and modifications may be provided for your child. When appropriate, parents should bring a copy of the child's IEP (Individual Education Plan) to assist with proper planning.
CLOW is geared for young minds and hearts - focusing on children that have not yet made their First Holy Communion.
They learn the traditions and meaning behind our Catholic faith; they listen to the proclamation of the Gospel and share in a discussion designed especially for them. After the prayers of the faithful they process back into church and rejoin their families for the Liturgy of the Eucharist.
Experiencing liturgy adapted for their age and experience teaches children to participate in the liturgy fully, actively, and consciously as they grow.
This ministry can only be offered to the extent that parents and other interested adults and teens volunteer to help make it happen. Please contact Karen Kirkland (ctkccd@cdlex.org) to find out how you can help our children fall in love with Jesus and the liturgy. You will be able to participate as you can and the benefits of doing so are everlasting!
This popular summer program takes place in mid- to late- July every summer. Register for VBS 2019 HERE. In the meantime, enjoy this short video of highlights from VBS 2016 where we had just under 200 children who spent a week drawing close to Jesus Christ!
For more info please email Amy (amwill0@yahoo.com) or visit americanheritagegirls.org.


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Business Valuation: An Analysis of Risk
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Avoiding the Biggest Deal Killer: Time
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Three Ways to Sell a Company
Top Excuses Owners Use to Avoid Exit Planning
Anatomy of a Letter of Intent
Should You Hire a Sell-Side Advisor or Do it Yourself?
Podcast: What an Opportunity Zone Investment Can Do for You and Your Capital Gains, an Interview with Brian Forcier
Life After Selling Your Business
Preventing Seller's Remorse in a Mid-Market Deal
Podcast: What Not Backing Down Can Cost You, an Interview with Michael Dash
Podcast: Planning for Transitional Challenges, an Interview with Jennifer Fondrevay
Private Equity Deal Sourcing Strategies in 2019
Surprises to Watch Out for When Selling a Business
3 Simple Ways to Start an Exit Plan in 2019
Choosing Between Strategic Buyers or Private Equity
Investors' Decision Making Process & Why You Should Know it Before Going to Market
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How Goodwill Impacts Business Value
Podcast: How to Play Defense - Tax Tips and Tricks
Like Rodney Dangerfield, Earnouts Just Don't Get Any Respect
Company Valuations and Why They're the Wrong Metric for Business Owners
The ABCs of Earnouts
Earnouts: The Double-Edged Sword for Sellers
Deal Source
M&A Directory
Sale Process
Maximize Value
Earnouts
Enterprise Value
Definition - What does Secondary Market mean?
Secondary market is the market where previously issued securities, such as stocks and bonds, are traded among investors. It is also the market where investors buy securities from other investors, and not from the issuing organization. The sale proceeds from the secondary market go to the investor, and not the issuing company. A primary market, on the other hand, is the place where the securities are given by the issuing organization for the first time and the proceeds go towards the capital of that organization.
Divestopedia explains Secondary Market
Secondary markets include all stock exchanges where investors buy or sell their securities with other investors. Because investors who deal with securities needed a place to exchange their offerings for money, the stock exchange emerged. Today, it is highly sophisticated and uses advanced technologies to provide real-time prices of any share.
Secondary markets provide the liquidity for investors and even for the economy as a whole. In general, the higher the number of investors, the greater the liquidity for that market. It is also in tune with the investors' preference for liquidity because most investors would not prefer to lock up their funds for long periods of time and the secondary market gives them the platform to have liquidity when they want it.
Besides the widely accepted definition of secondary markets, there also exists private secondary markets that deal with the buying and selling of investor commitments to private equity funds. In this market, the sellers not only sell their investments, but also the unfunded commitments, so that buyers have the choice to take any stake in private equity companies.
Both these types of secondary markets are heavily regulated by the national government of every country because they are an important source of capital formation and liquidity for companies, investors and the economy as a whole. Also, from a company's perspective, these secondary markets are an important way to monitor and control the public perceptions of the company. It helps with crucial management decisions such as incentive-based management contracts and aggregation of information through share prices.
Investment Bank (IB)
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NTM EBITDA
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Story Deal
Return on Data Assets
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Why do deals fall apart?
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Pastry tips attach to the end of pastry bags to pipe frosting, icing, jellies and more into beautiful shapes with precision. Pastry tips come in number of different sizes and shapes to accomplish different piping styles. The smaller the tip number, the smaller the opening size. Consider your piping design when selecting a pastry tip.


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Острова Авес (архипелаг Лас Авес) — ненаселённый архипелаг в Карибском море, принадлежащий Венесуэле. Входит в состав Подветренных островов. Он расположен к северу от венесуэльских штатов Арагуа и Карабобо, между голландским островом Бонайре на западе и архипелагом Лос-Рокес на востоке. Входит в состав Федеральных владений Венесуэлы. Основное экономическое значение островов — рыболовство.

Состав архипелага
Архипелаг состоит из двух атоллов:

 Авес-де-Барловенто, восточная группа, с окаймляющим рифом диаметром 8 км и тремя рифами на юго-западе.
 Исла Авес де Барловенто
 Исла Тесоро
 Кайо Буби
 Кайо-де-лас-Бобас
 Авес-де-Сотавенто, западная группа, с большим островом Исла-Масета,, покрытым мангровыми зарослями, на юге.
 Исла Авес де Сотавенто
 Исла Ларга
 Кайо Тирра
 Исла Сакисаки
 Кайос-де-ла-Колония
 Исла Масета
 Кайо Стерна

Всего в обеих группах 21 островок и один остров.

История
Лас-Авес был местом крупной голландской победы над французами в 1678 году, когда французский флот под командованием адмирала Жана Д'Эстре, направлявшийся к близлежащему голландскому острову Кюрасао, был заманен небольшими силами из трёх голландских кораблей на риф Авес-де-Сотовенто. Когда корабль Д'Эстре врезался в риф, он выстрелил из пушек в качестве предупреждения находящимся позади кораблям. Однако они интерпретировали сигнал как означающий, что он был атакован, поэтому они поспешили ему на помощь — и таким же образом ударились о рифы.

В итоге весь французский флот из 13 кораблей был потерян. Пресной воды на Лас-Авесе выжившие не обнаружили. Они пытались выжить на бочках с вином и соленом мясе, выброшенных на берег. Но эти припасы закончились, и в конце концов почти все погибли. Адмирал был одним из немногих, кого спасли. На Кюрасао вплоть до XVIII века отмечался День благодарения в ознаменование удачного спасения острова от разорения французами.

Острова Венесуэлы
Острова Карибского моря

redpajama_set_name: RedPajamaWikipedia


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Somaliland: Journalists detained in Somaliland for allegedly defaming officials
IFEX
National Union of Somali Journalists
The National Union of Somali Journalists (NUSOJ) is shocked and deeply saddened with the detention of journalists for allegedly "defaming" Somaliland officials and "publishing false Information".
Two journalists, Yusuf Abdi Gabobe, owner and chairman of Haatuf Media Network, and Ahmed Ali Igeh, Editor-in-chief of Haatuf newspaper were arrested by Somaliland police on 10 May 2014 inside the Hargeisa Regional Court after the court ordered their imprisonment.
The Hargeisa court heard complaints by Somaliland's Minister of Minerals, Energy and Water Resources, Mr Hussein Abdi Duale and Somaliland's Minister of Interior, Ali Mohamed Waran Ade who both came to the court and personally spoke to make their case of how Haatuf newspaper wronged them. The two ministers accused Haatuf of spreading false information and defamation, in order to kill their reputation and the one of Somaliland presidency. The hearing continued for five hours. At the end of the hearing, the two journalists were chained and taken to a detention centre.
Two lawyers defending the two journalists complained in the court about bias from the presiding judge whom they accused of siding with the prosecutor and Somaliland officials.
NUSOJ considers the arrest and treatment of Yusuf Abdi Gabobe and Ahmed Ali Igeh as unconstitutional and retrogressive for Somaliland's just rule of law and affront to freedom of expression.
"We find it uncalled for that journalists will be criminalised by writing about Somaliland officials. It is pure and simple harassment," said Omar Faruk Osman, NUSOJ Secretary General.
The arrest of Gabobe and Igeh is based on outmoded pieces of the Somali Penal Code enacted during the military government to suppress dissent and promote authoritarian rule. The prosecutor reportedly refused to base his charges against journalists on Somaliland's press law.
NUSOJ deplores the use of criminal defamation law through the Somali Penal Code, as it is a major obstacle to freedom of expression. This is in light of the fact that there is the option of civil defamation remedies.
The use of the criminal defamation provision in the penal code unnecessarily censures journalists in their work and induces self-censorship, thereby restricting the exercise of the right to freedom of expression.
"Our position is that the pursuit of criminal defamation is tantamount to criminalizing freedom of expression as guaranteed in the constitution of Somaliland and article 19 of universal declaration of human rights," added Osman.
Archaic laws have no role to play in a democracy and we call upon Somali authorities to desist from implementing them and dragging the country to the military era, declared Osman.
NUSOJ is particularly concerned about the threats to freedom of expression in cyberspace and strongly urges the local authorities and telecommunication companies not to set a very bad precedent in light of these developments. Somaliland ordered three telecommunication companies to block access to news sites of Haatuf newspaper and its sister newspaper Somaliland Times, which are currently inaccessible in Somaliland.
On 7 April 2014, a shutdown order against the independent daily newspaper Haatuf was implemented by Somaliland police after being issued by the Marodi Jeeh Regional Court in Hargeisa. Some hundred police forces came to the headquarters of the newspaper and ordered journalists and media workers to vacate. Police still occupy the premises of the newspaper.
Arresting journalists, shutting down independent media houses and blocking access to news sites will only tarnish the image of Somaliland authorities and ruin the benefits of dialogue. Only dialogue between authorities and the media would provide a more enabling environment for media freedom, freedom of expression and ultimately citizen empowerment.
Labels: Freedom of Speech, Media, Somaliland


It was 17 days after you had passed away – just 2 weeks and 3 days since we said our final goodbye and sat with you bedside for the last time before they came and took you away. In that 17 days we had planned a funeral, held a visitation, buried you, hosted a lunch at our home in Cincinnati with a saxophone player you would have loved, planned a vacation, and made our way to Florida for some much needed time away.
My week in Florida was good…I had smooth flights, we did some dinners out to eat, some swimming in the pool, shopping, and went to the ocean off and on during the days when it wasn't raining. On my final night in Florida, Friday the 23rd, the weather just seemed to cooperate and it had been gorgeously sunny all day. I sat on the beach with a Corona, did a workout alone, and came back to meet my mom for dinner by the pool. After dinner I decided I wanted to go on the beach for my last night – for it was really the only day that week we could see the sunset. The other days had been consumed with rain as a hurricane moved it's way through the gulf. I took myself out to the beach, and as I walked onto the sand, I started getting an overwhelming feeling of sadness. I laid my towel out on the sand, and just sat with my arms around my knees for a while. It was the kind of Summer night where you could be comfortable in a light jacket, or comfortable running around in a swimsuit – I'm unable to accurately explain the perfect temperature of that night in the words that it deserves. The humidity from the week had suddenly lifted and the breeze was lightly blowing as the ocean waves rolled in. Families all around me enjoying the sand, the water, and each other's company as the sun set to the right of me, covered the beach. The sky was hazy and the perfect amount of clouds lined the edge of the ocean. Live music was playing up by the pool and you could hear it out onto the beach as the sun got lower and glistened over the water. For the first time since you'd been gone, I felt alone, no longer swept up in the plans of how we'd lay you to rest or planning this glorious week "away" from it all.
Why weren't you there? You used to make my sisters and I get up at the crack of dawn to find the sunrise (I always passed on that) or make us drive to the perfect place on the island after dinner just to catch a small glimpse of the setting sun on our beach vacations. No way would there be this type of weather, this type of sunset and you not there walking the beach to enjoy it. I got that panicked feeling where you keep waiting for something to happen, for someone to come … it never does and they never appear. You keep waiting and hoping, knowing that it's not happening but that there could be a small chance. Finally I came back up to our room…my phone was dead and I needed to capture this sunset, this view in front of me that you weren't able to see from my point of view on earth. Mom reminded me that it was okay to feel sad and so I allowed 17 days worth of tears to come out in one night. I didn't expect this, as we had already spent so many weeks and months grieving prior to the actual day that my Dad had died. I stood on our beachfront balcony for hours and engrained this moment and picture into my mind. As it got darker, I decided to pull out my computer and get my thoughts out in writing before they escaped me forever.
How is it that just 1 year ago (to the week) you were with us on the beach – talking, laughing, swimming. Your incredibly tan toes walking the beach with us as you snapped photos, held your grandson, and gathered the family for what would be our last vacation photo as a family – and our last vacation as a family.
It's crossed my mind often how much I'll miss you on my wedding day in just 4 short months, at the hospital after the birth of my other children, or at our first family Hanukkah without you. It turns out when someone is gone, you can never get "away" – for they are always with you…in the big moments, the mundane moments, and ordinary moments such as a sunset on an otherwise ordinary evening or a neighborhood concert on a hot July night.
It took me 17 days to realize that you are never physically coming back, but that you will never truly be gone.


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Pricing & features
Legal validity
The most user-friendly signing solution in the Benelux
Join over a thousand companies that are using Stiply!
Electronic signatures - are they really valid?
The short answer: absolutely!
In most European countries, a contract is concluded by offer and acceptance. This can be verbal, on paper or electronically via, for example, the internet or e-mail, as long as the parties show that they agree with the content of the agreement. From then on, an agreement is legally valid.
Once everyone agrees to the agreement, it is binding and the parties must abide by its contents. When signatories express their agreement with a digital signature (also known as an electronic signature) from Stiply, a legally binding and therefore legally valid agreement is created.
Different types of electronic signatures
From Europe, three different levels are described. These levels are defined and elaborated in the eIDAS regulation.
This regulation distinguishes three types of digital signatures:
The simple electronic signature (SES);
The advanced electronic signature (AES);
The qualified electronic signature (QES).
In short, the degree of identity verification, also known as authentication, and the assurance of integrity of the document determines the signature level used.
Just as legally valid as a written signature
The 'ordinary' electronic signature (SES) is in principle just as legally valid as a signature made with ink. However, it is important here that sufficient care is taken around the identification of a signatory.
The law states in Article 3:15a of the Civil Code:
"An electronic signature has the same legal effects as a handwritten signature, if the method used thereby for authentication is sufficiently reliable, considering the purpose for which the electronic data was used and all other circumstances of the case."
Authentication is an important part of creating a digital signature. In Stiply's signing solution, various authentication methods are possible in addition to signing via just a mail address. Read more about the various authentication methods Stiply offers to support a legally valid digital signature.
"The rule of thumb is: the more important the contract or document, the better the authentication in the digital signature should be "
Evidential value of documents with a digital signature
So an electronic document with a digital signature is legally valid and parties must comply with its contents. But what if a dispute arises and you end up in court?
In that case, you can submit the digitally signed document combined with the evidence document to the court as evidence. The judge will almost always consider this evidence in his judgement. In the vast majority of disputes, the issue is about what is in the agreement, not whether there is an agreement at all. With a legally valid agreement from Stiply, you will be fine.
When does probative value come into play?
Evidential value comes into play when the other party says: "I have never seen this document and never signed it". Indeed, in these (rare) cases, you may have to prove that the agreement was indeed signed by the counterparty.
Therefore, it is important that you do a proper authentication check when signing a contract digitally. This will provide more evidential value.
The more important the contract the better the authentication.
In such a situation, the probative value of your electronically signed document depends on how the signer identified himself online. The court will therefore determine afterwards whether the identity has been sufficiently established, relative to the importance of the contract.
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"Balmoral", 4-room apartment 110 m2 on 2nd floor, south-east facing position. Bright, comfortable and beautiful furnishings: large living/dining room with open-hearth fireplace, dining table and TV (flat screen), radio, CD-player and DVD. Exit to the balcony, south facing position. 1 double bedroom with 2 beds and TV (flat screen), DVD. Exit to the balcony. 1 room with 2 beds. Exit to the balcony. 1 room, without wardrobe with 2 beds. Large kitchen (oven, dishwasher, 4 ceramic glass hob hotplates, microwave, raclette grill fondue Set (cheese)) with small dining table. Bath/WC, shower/WC, whirlpool. Large balcony 50 m2, east facing position and south facing position. Balcony furniture, barbecue, deck chairs (2). Partial view of the mountains. Facilities: washing machine, dryer. Internet (WiFi, free). Reserved parking space n 7, garage.
Apartment block "Balmoral", 3 storeys. In the centre of Villars, in a quiet, sunny position, in a cul-de-sac, south facing position. For shared use: property. In the house: lift, storage room for skis, washing machine, tumble dryer (for shared use, extra). Motor access to the house. In Winter: please take snow chains. Parking (limited number of spaces). Grocery 200 m, restaurant, bar 150 m, bakery 400 m, café 150 m, 2 minute walk to the centre, bus stop 600 m, railway station "Villars-Bretaye" 600 m, indoor swimming pool 500 m, thermal baths "Lavey-les-bains" 19 km. Sports harbour 25 km, golf course (18 hole) 7 km, indoor tennis centre, sports centre 900 m, mountain railway 600 m, gondola lift 750 m, ski bus stop 150 m, ski school 250 m, children's ski school 900 m, ice field 500 m, children's playground 400 m. Free ski bus service to the ski region de Villars.
très content, nous l avons réservé de nouveau.
Het is een mooi appartement met een mooie ligging. Gezien de prijs mag men verwachten dat alles hierin inbegrepen is. Dat achteraf blijkt dat er bijkomende kosten zijn is vervelend.


Ruark MRx Soft Grey is the latest addition to the award widnning Ruark product range, bringing not only wireless and versatility to high end audio but seamless streaming capabilities to match. The Ruark MRx model features aptX Bluetooth audio processing and a simple LED input indicator.
The Ruark MRx Soft Grey makes full use with the current trend of wireless audio without the compromises. Bluetooth aptX streaming with compatible devices offers a higher quality signal to be received similar to that of CD quality audio.


The shortest player on the floor stood tallest.
QB Jameis Winston back with Bucs, but will he start against Bears on Sunday?
26th September 2018 Ragas Clan Comments Off on QB Jameis Winston back with Bucs, but will he start against Bears on Sunday?


Veterinary specialists have many years of focused education and training for their specific area of expertise so they can determine the best course of action for your specific pet, using a comprehensive knowledge of all options available. ExpertVet.com is designed to give you access to information to let you see if your pet needs the care of a veterinary specialist.
The education of a veterinarian usually consists of 4 years (or a bachelors degree) university education before applying to veterinary school. Accredited US Veterinary School lasts for 4 years. At the end of that time (8 years of higher education) the students that pass receive a Doctorate in Veterinary Medicine (DVM or VMD for U Penn). They then qualify to sit for national and then applicable state board exams. If they pass they are able to practice as a veterinarian.
Some veterinarians decide to take their education even further and apply for a rotating internship with a specialty institution. For a year, these new doctors work extensive hours under the direct tutelage of some of the most highly trained veterinarians that exist, rotating from one area of specialty to the next. After that grueling year, veterinarians can go into practice, but some decide to apply for very competitive focused internships. These yearlong focused internships put the veterinarian in the hands of a specific specialist in a field where he or she wants to specialize. Focused interns get to be involved in advanced casework and often participate in research studies as well.
After a focused internship, the veterinarian can apply for one of the few resident positions available. Residencies last for 3-4 years. These positions provide academic, clinical and research education teaching the resident the most advanced information about all pathologies and treatments within their area of specialty. Residents learn practical realities, and physical skills of treatments alongside the academic details. Residents also have to conduct an original research project that is peer reviewed and accepted.
If the veterinarian completes a residency and submits research that is peer reviewed and accepted, he or she is qualified to take a multi-day examination testing knowledge, skills and the ability to apply them by the specialty college. Not all veterinarians who take the exam are able to pass. If the candidate passes the exam, they are a Board Certified Veterinary Specialist.
Only Board-Certified Veterinary Specialists are trained and certified to provide the best options and plan specifically for your sick or injured pet.


Tim McMillan has been performing his extraordinarily unique style of acoustic guitar based music for well over a decade across the globe. His incredibly lively performances, ability to inspire the audience and warped sense of humour have made him a popular live artist throughout Europe, where he now spends the larger part of the year.
He is joined by ultra-talented violinist Rachel Snow and the duo perform a distinctive mix of musical styles including fingerstyle guitar, Celtic rock, folk, metal & jazz. Tim and Rachels shows are filled with hilarious tales of life in the Australian bush, athletic guitar stunts and melodic songwriting.
In 2015, he was voted by Australian Guitar Magazine as one of the top 25 guitarists.
The past years have seen Tim sharing the stage with guitar legends Al Di Meola, Dominic Miller (Sting), Metallicas Rob Trujillo & Phil Campbell of Motörhead. Most recently Tim and Rachel have toured Europe with 90s rockers Ugly Kid Joe with Tim also joining them on acoustic guitar for the duration of the tour.
In 2017, Tim and Rachel released their fantastic album "Hiraeth" to much acclaim, affirming them as innovative and imaginative songwriters / musicians.
Voted by Australian Guitar Magazine (100th issue) - Top 25 guitarists.
We are delighted to welcome back this world class duo after last year's hugely successful concerts and they will be playing in the beautiful surroundings of Hospitalfield House.


Over the long term, the fact shows that the return is higher as compared to bonds or money equivalents due to its risky or volatile character. As we seen the impact by recent financial crisis, middle east turmoil as well as Japan's earthquake & tsunami tragedies to the stock markets, a lot of fear emotion in the market and people started to panic to sell off their investment holdings and look for safer returns.
Nevertheless, a lot of opportunities arise whenever there is a risk involved. As what Benjamin Graham mentioned, the intelligent investors are those who beat the market by being 'smarter' than other investors by doing a lot of detailed homework and thus enjoyed better returns than the rest.
well above bonds and cash equivalents. However, we should take considerations of how many percentage of equity we can allocate in our portfolio for the needs of different purposes such as retire planning, child education planning, short term emergency planning etc. This can avoid us to be overconfidence of what returns can equity gives to us as the returns always accompanied with the risk.
In next blog I will show you how to create a portfolio suitable to your short term and long term needs. But before that make sure you have basic financial knowledge.


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The TX features an all-new 5-color TD pigment ink set. This ink was formulated to produce fine lines and sharp text on both inkjet and non-inkjet paper. Combine this pigment ink with water resistant media and you have a printed drawing that can withstand the outdoor conditions of a construction site.
The dual-roll feeding mechanism enables users to load a second roll of media allowing for up to 3900 sq ft of continuous uninterrupted printing.
The Multifunction Roll System may also be configured by the operator as a take-up unit to rewind longer printouts. The user can choose to rewind media with the printed surface on the outside or the inside of the roll, thereby supporting "bi-directional rewinding".
The newly designed PF-06 is a 1.07-inch, 6-channel print head with 15,360 nozzles. Combined with the TX's high-speed carriage transfer and ink ejection, this print head allows for ink to be layed down quickly and precisely.


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Q: Accessing 3rd party iOS framework in NativeScript I want to access twilio ios framework in NativeScript project. What are the steps to follow?
Firstly I followed https://www.nativescript.org/blog/using-3rd-party-ios-frameworks-in-your-nativescript-apps
but got to know that "tns library add" do not work anymore.
Then I followed the NativeScript documentation and created the plugin following these steps. https://docs.nativescript.org/plugins/cocoapods
Folder structure of my plugin is also like mentioned in the link. My iOS project workspace have been successfully created.
I have no idea what steps to follow after this to access twilio in nativescipt project. Also twilio is in swift are there any additional steps to make it available. Please add sample code too, if possible.

A: Check out this https://docs.nativescript.org/plugins/Use-Native-iOS-Libraries
And make sure that the Swift-Classes are annotated properly.
i.e.
@objc(MathResult) //<-- This is important! Nativescript needs a named annotation.
public class MathResult {

    @objc
    public let value: Int;
}