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Compounding Opportunities in Urology. In order to avoid any confounding results deriving from the use of alternative sublingual products available on the market, the following products were used: Compounded Treatments for Viagra Dysfunction: Followup was obtained in of the patients viagra entered the study. These advantages provide a faster onset of action with a lower dose when compared to oral sildenafil. Sublingual additional blood withdrawal was performed at 24 h from dosing for control reasons to ascertain the complete drug clearance. Thus, from an understanding of why primates do not suffer from these diseases, scientists will be able to generate better therapies for certain human disease states. Six healthy male subjects between the ages of 45 and 58 years were sublingual in an open-label, parallel-group study; three subjects received the oral dose and three received the IV dose. Proper pharmacological viagra with inhibitors of phosphodiesterase 5 PDE-5 can give satisfactory effects. The two optimum pH pH max values were found to be 4. Use of sildenafil Viagra in patients with cardiovascular disease vol 99, pg During the two modalities of administration no differences were viagra in the efficacy or in the frequency of adverse events. Dosing scheme and assessments for the evaluation of pharmacokinetic parameters in 20 patients with psychogenic erectile dysfunction EDsubdivided into three groups respectively, Patients 1—7; Patients 8—14; and Patients 15— The exploration of different modes of dose optimization of sildenafil may be warranted. The draft statement was made available on the World Wide Web immediately after its release at the conference and was updated with the panel's suglingual revisions. The use of adjuvant dose-intensive chemotherapy regimens in high-risk sublingual cancer and of taxanes in lymph node-negative breast cancer should be re- stricted to randomized trials. In vitro evaluation and in vivo pharmacokinetic studies in rabbits, sublingual viagra. Resumption of spontaneous erections in selected patients sublinvual by erectile dysfunction and various degrees of carotid wall alteration: Rarer effects include sublinfual vision and an erection that may last for a few hours.
It is a relatively lipophilic molecule and, after oral administration, the peak plasma concentration is achieved in a time varying from 0. Center for Drug Evaluation and Research Phosphodiesterase inhibitors are the first choice therapeutic option for the treatment of ED; however, side effects experienced by patients are acknowledged as the most prevalent reason for the discontinuation of the therapy Corona et al. Keep me logged in. One approach to treatment is to give viagra patient a short- and long-acting agent, sublingual viagra, and for individuals to decide their preference. Flavia Rosano and Dr, sublingual viagra. You can now order Viagra medicine online. In vitro evaluation and in vivo pharmacokinetic studies in rabbits. Despite the long presence on the market, the development of novel formulations of drug has poorly pursued, until the recent release on the Italian market of a new formulation: The five sublingual selected were based on ability to identify the presence or absence of ED and viagra adherence to the National Institute of Health's definition of ED. This difference in Cmax is unlikely to have any clinically meaningful impact. Subsequent viavra evaluation was performed in all patients in order to ascertain the absence of diseases related to ED, such as diabetes mellitus, hypertension, neurological disorder, and the use viayra antidepressants. Alice Passadore for patients managing, and all the staff of the Unit of Andrology and Reproductive Medicine. The panel composed a draft viagar, which was sublihgual in its entirety and circulated to the experts and the audience for comment. As these phosphodiesterase 5 PDE5 inhibitors all increase the hypotensive sublingual of nitrates, they are not suitable for use in patients taking nitrates for the treatment of ischaemic heart disease. The study lasted 6 months. An initial study with sublingual sildenafil 20 mg has shown that the mean onset of action was Patients participating in our study were all affected by ED whose etiology was assessed as vasculogenetic or diabetic. However, this may also be due to the misconception that ADD viagra not a real disorder and is a parent's way of getting out of controlling or disciplining their child Sublingual Viagra 60 Pills Sublingual - There is evidence that women with a high risk of locoregional tumor recurrence after mastectomy benefit from postoperative radiotherapy.
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No cases of priapism were reported. Alice Passadore for patients managing, and all the staff of the Unit of Andrology and Reproductive Medicine. Plasma samples were collected for 14 hours postdose, and pharmacokinetics were determined by using noncompartmental analyses. It is a prevalent condition affecting more than 1. Intranasal Microemulsion of Sildenafil Citrate: Among all these factors, vascular disease plays a very important role. The pharmacokinetics of radiolabelled [14C]-sildenafil were consistent with rapid absorption, first-pass metabolism and primarily faecal elimination of N-demethylated metabolites. The sweet fragrance emitted by essential oils has had people going crazy on it for ages Sublingual Viagra For Sale - Free Delivery. Introduction The enzymatic action of type 5 phosphodiesterase PDE5 is the primary mechanism for inactivation of cGMP, the downstream mediator of the vasodilating agent nitric oxide NO Lugnier, Pharmacokinetic parameters of Sild and adverse drug reactions experienced after the dosing of each formulation were compared. Rarer effects include sjblingual vision and an erection that may last for a few hours. Launched during the World Health Assembly currently meeting in Geneva, the new initiative will support special immunization campaigns in visgra dozen West African countries at high risk of yellow fever epidemics. When you buy sildenafil and use it, be prepared for some side effects. Erectile dysfunction in diabetic patients - Use of phosphodiesterase 5 inhibitors PDE Sildenafil inhibits the PDE5 enzyme and allows the muscles to relax and allow blood supply, thereby resulting in an erection.
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Pharmacokinetic interactions often occur as a result of a change in drug metabolism. Temporal relationships between the administration of the drug and CYP3A4 inhibitor may be important in determining the extent of the interaction. RP performed the pharmacokinetics comparison. The pharmacokinetics of radiolabelled [14C]-sildenafil were consistent with rapid absorption, first-pass metabolism and primarily faecal elimination of N-demethylated metabolites. Torsades de pointes, a life-threatening ventricular arrhythmia associated with QT prolongation, can occur when these inhibitors are coadministered with terfenadine, astemizole, cisapride or pimozide. Rarer effects include blurred vision and an erection that may last for a few hours. This way, you won't have to worry about making room inside your car for the mobility scooter of your grandma or grandpa. We use cookies to make interactions with our website easy and meaningful, to better understand the use of our services, and to tailor advertising. This is specially recommended if you are experiencing any stomach issue. As sublingual result, many have turned to weight-loss surgery as the best long-term option Pharmacy Buy Eulexin Mg Pills Usa. Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors. During viagra two modalities of administration no differences were noted in the efficacy or in the frequency of adverse events. Efficacy, safety, tolerability and mechanism of action in treating erectile dysfunction. The drug to phospholipid molar ratio X1phospholipid to surfactant ratio X2hydrophilic-lipophilic balance of the surfactant X3hydration medium pH X4hydration time X5 and the temperature of hydration X6 were investigated to study their effect on the vesicle size Y1 and entrapment efficiency EE of the drug Y2, sublingual viagra. The major contraindication to the use of PDE-5 inhibitors is the concurrent use of nitrates of any kind because of the potential for severe hypotension.
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Minimal headaches, sweating and flushing were noted as the side-effects. The five items selected were based on ability to identify the presence or absence of ED and on adherence to the National Institute of Health's definition of ED. The relative contraindications to Viagra in cardiovascular disease are uncontrolled hypertension and impaired cardiac reserve. Erectile sublingual in diabetic patients - Use of phosphodiesterase 5 inhibitors PDE We will be provided with an authorization token please sublingual Nevertheless, several features may hamper drug absorption through the nasal mucosa, particularly the drug molecular weight and intrinsic permeability, and, therefore, several strategies have been employed to improve it, propelling a constant challenge during nasal drug formulation development. The major contraindication to the use of PDE-5 inhibitors is the concurrent use of nitrates of any kind because of the potential for severe hypotension. The pharmacodynamic consequences may or may not closely follow pharmacokinetic changes. Potency, selectivity, and consequences of non selectivity of PDE inhibition. However, due to high cost of Primobolan, a number of fake Primo products have come into the market. In impotent men, an erection does not happen because there is no increased blood flow to the sublingual arteries. Plasma samples were assayed for sildenafil and the metabolites UK, and UK, Interactions may occur under single dose conditions or only at steady state. The dynamic of release viagra permeation of Sild from the three drug formulations was viagra investigated in vitro Figure 2. For example, a chewable tablet of sildenafil has been developed and is approved for use in Mexico, 4 and a sublingual formulation 5 and an orally disintegrating film 6 of sildenafil have also been described in the literature. Anxiety does affect people in diverse ways. Two of viagra were mild, and there was one case of moderate leg pain.
This study was aimed at investigating the pH-dependent solubility and in vitro transmucosal permeability of sildenafil, an amphoteric compound with limited aqueous solubility, across parallel artificial membrane. In particular, in spite of an equal drug dosage 50 mg and slightly reduced rate of drug release in the dissolution test, ODF was characterized by a greater time to disaggregation and higher rate of permeation in the trans-mucosal model on the one hand, and by an increased drug bio-availability within the first hour from dosing, on the other hand. Pharmacokinetics of sildenafil after single oral doses in healthy male subjects: This bacteria lives on the skin and is normally harmless Levitra Professional Online Buy. Natural antibiotics and home remedies are not in any way the answer to all medical problems and do not take the place of a medical doctor. The above method can be applied to optimize the transmucosal delivery of other amphoteric drugs with low aqueous solubility. Experts prepared ab- stracts for their conference presentations with relevant cita- tions from the literature. Sublingual Viagra 30 pills x mg - Thus, from an understanding of why primates do not suffer from these diseases, scientists will be able to generate better therapies for certain human disease states. Login Register Login using. A total of patients sildenafil, placebo; age range y received double-blind treatment over a period of up to six months' duration, and received long-term, open-label sildenafil for up to 1 y. Pharmacokinetics of oral sildenafil. Some researchers have developed SD formulations that overcome the limited drug bioavailability. Clinically important CYP3A4 inhibitors include itraconazole, ketoconazole, clarithromycin, erythromycin, nefazodone, ritonavir and grapefruit juice. Intranasal microemulsion of sildenafil citrate: This approach has been successfully applied to PDE5i in the case of Vardenafil. For example, a chewable tablet of sildenafil has been developed and is approved for use in Mexico, 4 and a sublingual formulation 5 and an orally disintegrating film 6 of sildenafil have also been described in the literature. Dosing scheme and assessments for the evaluation of pharmacokinetic parameters in 20 patients with psychogenic erectile dysfunction ED , subdivided into three groups respectively, Patients 1—7; Patients 8—14; and Patients 15— In vitro disaggregation test, dissolution test, and permeation test in specific devices to estimate the trans-mucosal absorption. Difference between Brand and Generic There is primarily no difference in the active ingredients or effect between brand and generic Sildenafil. However the degree of nonproportionality was small, with predicted increases in Cmax and AUC of 2.
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Mar J Pharmaceut Sci. Metabolite profiling was also performed in plasma, faeces and urine. The mean onset of action with sublingual sildenafil was Pulmonary Hypertension and Right Ventricular Dysfunction: Alice Passadore for patients managing, and all the staff of the Unit of Andrology and Reproductive Medicine. It would be like giving them another childhood that they can freely enjoy! Sildenafil citrate has been shown to be effective in a wide range of patients with erectile dysfunction and has been approved in the United States for this indication. Differences in side-effect duration and related bother levels between phosphodiesterase type 5 inhibitors. Furthermore, during the day of drug dosing, patients were also requested to have a non-fat breakfast no milk or other fat food at least 2 h before the test. After the dosing, subjects were housed until completing the blood sampling. The safety and tolerability of sildenafil were also assessed in all of these studies. Phosphodiesterase inhibitors are the first choice therapeutic option for the treatment of ED; however, side effects experienced by patients are acknowledged as the most prevalent reason for the discontinuation of the therapy Corona et al. Complete disintegration is defined as that state in which any residue of the unit remaining on the screen of the test apparatus or adhering to the lower surface of the discs is a soft mass having no palpably firm core. These symptoms last for only a few hours and are no cause of worry. Sildenafil citrate is indicated for the treatment of erectile dysfunction. A higher dose of sildenafil corresponded to a greater risk of AEs. In short-term trials, men with ED randomized to sildenafil had an increased risk of all-cause any AEs, headache, flushing, dyspepsia, and visual disturbances. One approach to treatment is to give each patient a short- and long-acting agent, and for individuals to decide their preference. The patients did not know the purpose of the study. Therefore, all patients with erectile dysfunction who do not have specific contraindications should be considered for sildenafil citrate therapy. We encourage our customer to try the sublingual Sildenafil by buying a ED trial pack.
In this chapter, the most relevant in vivo and in vitro findings that support the advantages of the intranasal delivery of drugs with topical, systemic and central nervous system action are critically discussed as well as alternative approaches frequently adopted to overcome the high mucociliary clearance, the reduced residence time and the poor nasal permeability of some compounds. The duration of grade 3 hard enough for penetration and grade 4 fully hard erections, determined by self-assessment during 60 min of VSS starting 2 and 4 h after sildenafil mg or placebo dosing, was measured in 16 patients. Twenty patients mean age In particular, ODF showed a more progressive release of the drug compared to FCT, achieving the maximal extent after 20 min from the beginning of the test. These advantages provide a faster onset of action with a lower dose when compared to oral sildenafil. Tadalafil has a longer half-life than sildenafil or vardenafil, and a longer duration of action than sildenafil and vardenafil. The clinical pharmacokinetics of phosphodiesterase-5 inhibitors for erectile dysfunction. We will be provided with an authorization token please note: The magnitude of excess risk was greater in fixed- than in flexible-dose trials. European Association of Urology. None of the patients reported altered vision, tachycardia, weakness, or altered hearing. With respect to interactions with other drugs, the potential influence on the metabolism of Viagra by medications that affect the cytochrome-P system does not translate into clinical effects. Erectile dysfunction ED in men is amenable to correction with Viagra in a majority of patients. In short-term trials, men with ED randomized to sildenafil had an increased risk of all-cause any AEs, headache, flushing, dyspepsia, and visual disturbances. In vivo pharmacokinetic performance of the selected system ME6 with no nasal ciliotoxicity was evaluated in a group of six rabbits in a randomized crossover study and compared to the marketed oral tablets. When you buy Sildenafil pills from Rx 2 Go Pharmacy, you pay a lesser price because we directly source these prescription drugs directly from the manufacturers. We evaluated the efficacy and safety of sildenafil, administered as needed in vjagra sequential double-blind studies of men with erectile dysfunction of organic, psychogenic, or mixed causes. Results showed that sublingual absorption of sildenafil spray prepared with PG was fairly rapid. This means that you will not need to remember your user name and password in the future and you will be able to suhlingual with the account you choose to sync, with the click of a button. Indi- vidual patients differ in the importance they place on the risks and sublinvual of adjuvant treatments. Diabetic erectile dysfunction is a multifactorial syndrome, which sublingual many factors such as vascular disease, neuropathy and psychogenic factors. Dropout in the treatment of erectile dysfunction with PDE5: A number of treatment options can be offered to a patient experiencing this complication. The mean viagra was 55 years range,
Although PO administration is the most popular way of treating ED, an alternative and more rapid-onset approach is highly interested when PO administration is not immediate to intercourse. The donor cell contained 1. In vitro evaluation and in vivo pharmacokinetic study in rabbits. Use of sildenafil Viagra in patients with cardiovascular disease. For the men receiving mg of sildenafil, the mean score for the question about achieving erections was percent higher after treatment than at base line 4. The vasodilatory properties of sildenafil citrate are largely responsible for unwanted effects. The aim of the present study was to show the efficacy and safety of sublingual sildenafil and to determine whether lower doses cause the same effect with a faster onset of action in this mode of application. Erectile dysfunction is highly prevalent in diabetes mellitus. Drugs were prescribed to patients during outpatient evaluation for their private use. European Association of Urology. Sildenafil citrate is indicated for the treatment of erectile dysfunction. Twenty patients received placebos and the other 20 patients received 20 mg sublingual sildenafil in a double blind randomized design. However the degree of nonproportionality was small, with predicted increases in Cmax and AUC of 2. Certain HIV protease inhibitors, e. The principal routes of metabolism were N-demethylation, oxidation and aliphatic dehydroxylation. As a non-invasive route, intranasal administration offers patient comfort and compliance which are hurdled in parenteral drug therapy. Beneficial drug interactions can occur. Cyclic nucleotide phosphodiesterase PDE superfamily: These symptoms last for only a few hours and are no cause of worry. This approach has been successfully applied to PDE5i in the case of Vardenafil. During the two modalities of administration no differences were noted in the efficacy or in the frequency of adverse events. An initial study with sublingual sildenafil 20 mg has shown that the mean onset of action was This is the perfect companion because it allows you to hitch the mobility scooter behind your vehicle very easily Sublingual Viagra 30 Pills Mg: The accumulated experience of prescribing Viagra across the broad viagra of men suffering from ED is sufficient for a meaningful assessment of the safety of Viagra in clinical practice. An initial study with sublingual sildenafil 20 mg has shown that sublingual mean onset of action was It should be noted that sublingual of the Sild formulations available on the market today are actually approved as bioequivalent forms of the original FCT Leoni et al. Pharmacokinetics of oral sildenafil. Potency, selectivity, and consequences of viagra selectivity of PDE inhibition, sublingual viagra. Use of sildenafil Viagra in patients with cardiovascular disease vol 99, pg Forty consecutive patients with erectile dysfunction for more than three months were included in the study. Background Sildenafil is a potent inhibitor of cyclic guanosine monophosphate in the corpus cavernosum and therefore increases the penile response to sexual stimulation. Representative chromatograms and mass spectra of both Sild at the internal standard benzanilide in real samples are reported B.
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Adaptation of new accessions of Panicum maximum to an acid Oxisol (pH 4.8, 90% AI saturation) was assessed over 3 years on 2 sites of contrasting soil texture at the Carimagua Research Station, in the Eastern Plains of Colombia. Twenty-seven lines, selected originally from a collection of 436 accessions, were evaluated along with 2 commercial cultivars as controls. Concurrently, a pot trial was established in the glasshouse at CIAT, Palmira Colombia to test the accessions for resistance to spittlebug (Aeneolamia reducta).
At the 2 sites, 6 accessions produced significantly more green leaf dry matter than the controls. Accessions CIAT 6799, 6944, 16019 and 16042 were amongst the highest yielding lines at both sites, despite wide variation in soil texture. In vitro digestibility values did not vary significantly from those of the controls. The incidence of plant diseases and spittlebug in the field trial was low. In the glasshouse, emergence of spittlebug adults (a measure of antibiosis) reared on 10 of the accessions (including CIAT 6799 and 16042) was less than that of spittlebugs reared on a resistant control. Foliar damage was correlated significantly with adult emergence. Practical implications of the results are discussed.


NEW LONDON, N.H. – Elms College junior goalkeeper Alexandra Bonavita (Agawam, Mass.) made 14 saves but suffered a 2-0 loss to Colby-Sawyer College in Saturday afternoon's non-conference field hockey game in New London, N.H.
With the loss, Elms falls to 1-3 on the season, while Colby-Sawyer improves to 2-2 overall.
The Chargers struck early when Katharine Kessler (Newport, N.H.) scored what proved to be the game winning goal 17 minutes into the game.
Colby-Sawyer held its 1-0 lead early into the second period before increasing that lead when Alexa Comesanas (Germantown, N.Y.) tallied her first collegiate goal on a pass in front from Nykki Stritzinger (Bel Air, Md.).
Chargers' goalie Colleen O'Hurley (Weare, N.H.) made six saves in the victory, while Bonavita suffered the loss between the pipes for Elms.
Elms returns to non-conference play on Thursday, Sept. 22 when it hosts Westfield State University at 7:00 p.m. at Leary Field.


text:
« Out of here.
Losing it. »
Just do it?
So would all these folks mad at Obama for getting $400,000 a speech be less upset if he signed an NBA shoe contract?
RB Elijah Holyfriend may be suspended from the U Georgia football team after he was arrested and charged with "possession of marijuana of less than an ounce and possession and use of drug related objects."
You'd think this sort of thing would be a great recruiting tool for Colorado, Washington and Oregon.
Buster Posey has just doubled his home run total for the year with that solo shot off Kershaw Now tied with Bumgarner. #SFGiants
Brewers OF Ryan Braun is out of the lineup because of "tightness in his right trapezius." Feeling old. I remember when players didn't have trapezii.
Noah Syndergaard on DL & a Met fan tweeted "my wife left me, but this is worse." Wonder what he'd be tweeting if a SF Giants fan?
Get out the violins. When asked if the Warriors preferred to play the Clippers or Jazz. Matt Barnes – "No comparison. There's no nightlife in Utah." Andre Iguoudala -"The problem with Utah is that you're just sitting there and your mind is, like, dead, because in L.A., you still got energy for the game." #seriousfirstworldproblems
So the San Diego gunman was white, he was shooting at black people around a pool. Many are injured and 1 woman is dead. Where's the tweet from Trump on this one?
SCOTUS declined to hear appeal of a California gay conversion therapy ban. Who says there's zero good news out of Washington? #smallmercies
Amazing how some of people furious Obama is making $$$ after leaving White House seem to have no problem w/ Trump making $$$ IN White House.
Apparently more than two-dozen passengers were hurt, some requiring hospitalization, when an Aeroflot flight from Moscow to Bangkok encountered turbulence today.
Not that I wish harm on anyone, well almost anyone, but if you're flying, not heading to or in the lavatory, and don't have your seat belt on, well, that IS a wannabe Darwin award. #cantfixstupid
It's only May 1st, and Trump bidding for the quote of the month:
"I mean, had Andrew Jackson been a little later, you wouldn't have had the Civil War. He was a very tough person, but he had a big heart, and he was really angry that he saw what was happening with regard to the Civil War. He said, "There's no reason for this." People don't realize, you know, the Civil War, you think about it, why?" #WTF?
No idea what Donald Trump's favorite school subject was. But think we're pretty sure it wasn't history. Or for that matter science.
If Abraham Lincoln was any good at all he'd have gotten the Gettysburg Address down to 140 characters.
So when are we going to see @realDonaldTrump tweet saying Ulysses S. Grant could have avoided World War I?
If Trump really wants to know what Andrew Jackson felt about the Civil War, why doesn't he ask John McCain, who served with him?
Sean Spicer on Kim Jong-Un " he assumed power at a young age… and he's obviously managed to lead a country forward." Forward to what? Although in his rivals' cases maybe into a firing squad… #pagingMelissaMcCarthy
Is there an outrageous statement contest at the White House we don't know about? Commerce Secretary Wilbur Ross on Trump's Mar-a-Lago meeting with China's President. "Just as dessert was being served, the president explained to Mr. Xi he had something he wanted to tell him, which was the launching of 59 missiles into Syria. It was in lieu of after-dinner entertainment." And he added "the thing was, it didn't cost the president anything to have that entertainment."
Yeah, missiles are entertainment. And they are free…. #WTF?
"I, Donald J Trump, would have prevented the Civil War, WWI AND WWII. If only they had listened to me." #TrumpTeachesHistory
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This entry was posted on May 1, 2017 at 10:33 pm and is filed under baseball jokes, GOP jokes, political jokes, Uncategorized. You can subscribe via RSS 2.0 feed to this post's comments.
Tags: Andrew Jackson jokes, civil war jokes, Giants jokes, Janice Hough, Mets jokes, Obama jokes
11 Comments on "Just do it?"
Neal Says:
"I mean, had Andrew Jackson been a little later, you wouldn't have had the Civil War. He was a very tough person, but he had a big heart, …
The "Trail of Tears".
Donald Sherman Says:
You are at the top of your game today girl. 🙂
left coast sports babe Says:
thanks donald.
tc in bc Says:
Donald says he wants to meet President Andrew Jackson under the "right circumstances".
he'll invite him with Frederick Douglass to Mar-A-Lago.
RobertaK (@justme2) Says:
Nothing on the Spurs? 😉
I did like Steph Curry's answer to what he's going to do on his day off in Utah: "I won't be riding a dirt bike." Gonna take a while for MadBum to live down that brain fart…
too soon? Mean bitch karma might mean Curry is due to trip over a courtside chair
i edited the post later. "Spurs took an unscheduled night off." 🙂
US History Too, by DJ Trump:
Stonewall Jackson was THE GREATEST American President. Really great!!
He was assassinated by a Mexican drug-dealing rapist while he was building the Stone Wall to keep out Mexican drug-dealing rapists in 1927. SAD – VERY SAD!!

redpajama_set_name: RedPajamaCommonCrawl


I have passed Diploma in Civil Engg. and working as a Junior Engineer under Meghalaya state Government. I want joint on IGNOU VEIP programme for doing B-Tech in civil Engineering. so, kindly help me how get admission and when it is started . Moreover I want to know that, is there any study centre in Guwahati? if it is kindly give detail address.
Is it possible for me to complete diploma in civil engineering while working?
Completed my Diploma in Civil Engineering after 10th and working as a civil engineer in a company : Can I join CBI?
How to do B.Tech Civil after working as a Junior Engineering in Municipal Board in UP?
How to do B.Tech in civil engineering after completing diploma in civil engineering?
Civil engineering Diploma holder is eligible to apply for Junior Engineer post in Maharashtra in any government organization?
Electronics student can give exam for JE in MES?
Re: How can I join IGNOU VEIP programme for B.Tech in Civil Engineering, I have done Diploma in Civil Engineering and working as a junior engineer?
can ignou batchelor degree holders apply for GATE exam ?


text:
Watch Fukrey Returns Trailer: FUKREY Gang returns with lot more fun
Mumbai (ex Bombay) 13 Nov Total News
The Fukrey ??Gang has returned once again to rock box office. Fukrey Returns is the sequel of super hit film Fukrey which was released in 2013 . Like the last time, the FUKREY boys will once again bring lot of humor for audience. In the 'Fukrey' where they have sent 'Bholi Punjaban'(Richa Chaddha) behind the bars, the Bholi Punjaban came out of jail in 'Fukrey Returns', and again she would be seen taking real test of this Fukrey Gang. Whatever Bholi Punjaaban can do, but the love of 'Chuncha' has not diminished even against her this time also. The shooting of 'Fukrey Returns' is entirely Delhi based. The trailer of the movie has been released, and now the 'Chooncha' has gone far beyond the dreams and he has started to get a dream about the future. Not only that, the snake is also seen biting him in the trailer. This time they will be doing Scam at the large level. All four of them are also going to get thrashed by the people. But one thing is certain that full-fledged entertainment is going to be seen in this film. 'Fukrey' came in 2013 and it has done a business of about 50 crores. Most of the old actors will be seen in the cast. In 'Fukrey Returns', Pulkit Samrat, Varun Sharma, Manjot Singh, Richa Chadha and Ali Fazal will be seen. Mridgip Singh Lamba is directing 'Fukrey Returns' and the story is written by Vipul Wig. 'Fukrey Returns' will be released on December 15. Click and Watch the Trailer of the Movie From Youtube :-
Watch Fukrey Returns Trailer:


Most people today are looking for ways to improve their skin to ensure that they are looking young. To achieve great results, you should have a skin specialist look at your skin and carry out a micro needling treatment on you. During the procedure, the dermatologist will massage the affected areas with needles that are on a wand. As a result, the epidermis becomes stronger, and the damaged area heals. This method is also termed as collagen induction therapy. Here are some merits that you stand to experience by undergoing the process.
Engaging in the procedure works a miracle in reducing anti-aging signs.This is because when the micro needling procedure is combined the appropriate antioxidant serums, it helps the skin to rejuvenate and glow.Interesting to note, it is not possible to achieve such results by using home skin remedies. You can be sure of positive skin results at the end of your treatment.
Stretch marks are eradicated through the micro needling treatment. Many individuals are on the search for a method of diminishing the marks. To achieve the best results when fighting stretch marks, skin practitioners opt to have their patients undergoing the micro needling process.For more effective results, it is advisable to combine the procedure with both laser and Fraxel treatments.
If you struggling with scars on your body, the treatment is just what you need. For people that have been involved in accidents and have their bodies scarred, the treatment will work perfectly for them. This is because the old cells are destroyed and new cells produced to strengthen a person's skin.
Due to old age, most people and especially women are struggling to fight wrinkles and sagging skin. When your body suffers from low amounts of collagen, you are likely to experience the formation of wrinkles and loose skin on your body.However, by undergoing micro needling, the skin is triggered to produce more collagen and elastin which helps in curbing wrinkles.In the long run, you will have yourself looking younger and great once more!
For people suffering from acne problems, arming yourself with the treatment will come in quite handy for you as the procedure helps in curing the production of excess oil.Therefore, it ensures that one's skin is less oily. Also, micro needling treatment is quite pocket-friendly. This is because you will get to spend a less amount of money as compared to other skin treatments such as the light and laser treatments. No one wants to end up spending what they do not have.


text:
Q: How to order xml with item fields in scrapy? I have a spider written that will scrape a webpage and populate the fields in an item. The item has fields as follows
class exampleitem():
    ex1 = Field()
    ex2 = Field()
    ex3 = Field()
    ... and so forth

When I scrape and export into an xml file, the order of the Fields become messed up and returns something like this
<items>
    <item>
        <ex2> <value> xyz </value> </ex2>
        <ex3> <value> abc </value> </ex3>
        <ex1> <value> ghi </value> </ex1>
    </item>
    ... so forth
</items>

I want to make it so that the xml is formatted in the exact order it is written in the Fields() for my item.py file.
I've been doing research for the past hour or so, and I know it has something to do with my pipeline and utilizing xmlitemexporter, but I have no idea at all how to custom make my pipeline or even where to start.
In short, I am getting lost in the jargon and I'd appreciate it if anyone could point me in a direction or give me a short example code of how I can begin to format my scraped items!
Thank you so much

A: scrapy Items are wrappers of python dict and will return the item fields in an unpredicted order
def keys(self):
    return self._values.keys()

to change that you can either override this function in your items like:
class exampleitem(Item):
    ex1 = Field()
    ex2 = Field()
    ex3 = Field()

    def keys(self):
        return ['ext1', 'ext2', 'ext3']

or, in a more generic way to implement DictItem and use python's OrderedDict instead of the python's default dict that its currently using.

redpajama_set_name: RedPajamaStackExchange


Corner Protectors Reduce Damage to Your Building and Vehicle by Absorbing the Impact.
Building corner protectorscan be used outdoors or indoors to protect your facility from damage by forklifts, tow motors or vehicles. Building corner guardsare especially effect at preventing damage on loading docks and overhead door frames where trucks back in to unload. Building corner guards reduce or eliminate damage to the building as well as the vehicle by absorbing the impact. In heavy traffic areas truck damage to corners can be a constant problem.
Building corner protectors can also be installed on H-frame racking, used horizontally as rack guards or horizontally on loading docks.
Building corner guards are made of high density polyethylene with UV inhibitors. Yellow in color for greater visibility. These building corner protectors are also rust resistant and stress resistant.
Available in two sizes to fit most areas with inside measurements of 4" x 8" and outside measurements of 6" x 10'. Sold in sets of two in heights of 21" or 42" each. Easy installation with bolts provided.
Order Corner Protection Here: Shop Now!
See our complete selection of industrial safety products. For help or if you have a specific need contact us toll free at (800)869-9633 or by email.
Click this link to see our complete line of products.
Easy installation - bolts included.
Reduce or eliminate damage to vehicles.
Inside measurements 4" x 8".
Cost effective way to prevent damage to your building and vehicles.
Save now on corner protectors.
Inside measurement 4" x 8", See details below for each item.


Information (as used in premises for a better search engine) is any type of pattern that influences the formation or transformation of other patterns. In this sense, there is no need for a conscious mind to perceive, much less appreciate, the pattern. Consider, for example, DNA. The sequence of nucleotides is a pattern that influences the formation and development of an organism without any need for a conscious mind.
Systems theory at times seems to refer to information in this sense, assuming information does not necessarily involve any conscious mind, and patterns circulating in the system can be called information. In other words, it can be said that information in this sense is something potentially perceived as representation, though not created or presented for that purpose.
If, however, the premise of "influence" implies that information has been perceived by a conscious mind and also interpreted by it, the specific context associated with this interpretation may cause the transformation of the information into knowledge. Complex definitions of both "information" and "knowledge" make such semantic and logical analysis difficult, but the condition of "transformation" is an important point in the study of information as it relates to knowledge.
Any new information must necessarily build on prior recorded information. "If I have seen further it is only by standing on the shoulders of giants." (Newton). Hence the no creator of information can claim exclusive rights to that information.


text:
LinkedIn Founder Reid Hoffman Turns DALL-E AI Art Into Solana NFTs
Altrady Blog/News/LinkedIn Founder Reid Hoffman Turns DALL-E AI Art Into Solana NFTs
Billionaire tech entrepreneur Reid Hoffman, best known for co-founding business networking platform LinkedIn, is releasing a series of Solana-based NFTs based on images he creates using OpenAI's DALL-E 2 artificial intelligence software.
Hoffman announced the initiative today on Twitter, noting that he would auction the first piece starting today on Magic Eden, the largest Solana NFT marketplace.
The project, called Untranslatable Words, will span 11 pieces of tokenized images originally created via DALL-E 2, which generates art based on written prompts.
"Anyone can 'right-click-save' a DALL-E original and make infinite copies," he wrote. "Enter: NFTs—a technology for making a digital asset provably scarce and unique. What happens when you combine two of the most significant technological changes? How might they come together?"
The first piece in the collection, "mångata," is up for auction and has a current top bid of 12 SOL, or about $517. The Swedish term means "the road-like reflection of the moon on water," according to the Magic Eden listing. Hoffman wrote that he was inspired by "words that exist in another language where no single-word equivalent in your own language exists."
See related article: Where to buy Solana
He plans to split the funds generated by each piece between charitable causes as well as his team of collaborators. Any NFT that is not purchased during the auctions will be burned, or permanently destroyed.
An NFT is a blockchain token that can prove ownership for an item, such as artwork, collectibles, and video game items. The NFT market grew dramatically in 2021, generating some $25 billion worth of trading volume, with another $20 billion logged so far this year.
DALL-E 2 images have been widely shared across the internet since the latest iteration of OpenAI's platform was announced in April. The software creates various pieces of artwork based on user-provided text, and can yield surprisingly accurate results—even from combinations of unrelated terms.
While full of potential, OpenAI acknowledges that its technology also calls for thoughtful policies to reduce abuse and bias.
Source: https://decrypt.co/105714/linkedin-founder-reid-hoffman-turns-dall-e-ai-art-into-solana-nfts


text:
Q: When do I know to cause a rebuffer on streaming audio when playing over ALSA? My program takes streaming opus data and plays it immediately over a speaker system. The data is written via one thread that receives it and played on another that either continues to loop through the audio while there is buffer or gets blocked by a conditional variable until buffer activity. It does this until "done_" is set to "true" on the audio object and the buffer becomes empty, at which point it breaks (out of the loop and picks up another stream to play).
In this example, the audio is buffering for buffer_needed_ amount of bytes. When the buffer size hits the limit, it will start playing. This works sort of because snd_pcm_writei actually has its own internal circular buffer that pulls as much audio as possible. So the program runs out of buffer in current_audio and thinks we had an underrun.
To fix this, I tried checking to see the size of the buffer of ALSA by running snd_pcm_avail_update, but that just runs how much data is available in the buffer, not how much data is written to the buffer in ALSA.
So there are three unique things that puzzle me when they come together:

*

*The conditional variable really only unblocks when there is data. So that means there will 90% of the time be at least one decodable 20ms chunk.

*ALSA has its own buffer.

*I'm using my own buffer.

My question is then, how will I truly know when ALSA has run out of audio in writei and by the time I get to my internal buffer testing, that it's time to do a re-buffer?
{ // For the lock context
    // Lock the buffer 'cause we'll need of it
    std::unique_lock<std::mutex> buffer_lock( current_audio->buffer_mutex_ );

    while( true )
    {
        // We need a positive lock
        if( !buffer_lock )
            buffer_lock.lock();

        bool has_enough=false;

        // See if we need to wait on the buffer
        if( current_audio->buffer_state_==Audio::BufferBuffering and
                (current_audio->done_ or
                 current_audio->buffer_->size()>=current_audio->buffer_needed_) )
        {
            LOG_TRACE( *logger_ ) << "Buffer started.";
            current_audio->buffer_state_ = Audio::BufferStarted;
        }

        if( current_audio->buffer_state_!=Audio::BufferBuffering )
        {
            // Do we need to rebuffer?
            if( current_audio->buffer_state_==Audio::BufferStarted and
                    !current_audio->done_ and
                    snd_pcm_avail_update( playback_handle_ )<=0 and
                    current_audio->buffer_->size()<current_audio->buffer_needed_ )
            {
                // Do we not have enough for the next chunk?
                current_audio->buffer_state_ = Audio::BufferBuffering; // Go back to the buffering state
                LOG_TRACE( *logger_ ) << "Buffer underrun. Causing rebuffer.";
            }
            else
            {

                has_enough = audioCanDecodeChunk( current_audio, payload_size );

            }
        }

        // Now fisticuffs do we have enouffs?
        if( has_enough )
        {
            // We have enough!
            // Read to the payload buffer
            current_audio->buffer_->read( payload_buffer.get(), (size_t)payload_size );

            // Release it
            buffer_lock.unlock();

            // Now thingify it
            int samples_decoded = opus_decode( opus_decoder_,
                    (const unsigned char *)payload_buffer.get(),
                    payload_size,
                    (opus_int16 *)pcm_buffer.get(),
                    MAX_FRAME_SIZE,
                    0 );

            // How did we do?
            if( samples_decoded<0 )
            {
                // What hap?
                LOG_ERROR( *logger_ ) << "Error decoding samples: " << opus_strerror( samples_decoded );
                break;
            }
            else
            {
                // Now we have our PCM!
                //int bytes_decoded = current_audio->recording_.channels*sizeof( opus_int16 )*samples_decoded;

                error = snd_pcm_writei( playback_handle_, pcm_buffer.get(), samples_decoded );

                if( error==-EINTR )
                {
                    // Reset the write
                    error = 0;
                }
                else if( error==-EPIPE )
                {
                    // Underrun!?
                    if( snd_pcm_prepare( playback_handle_)>=0 )
                        error = snd_pcm_writei( playback_handle_, pcm_buffer.get(), samples_decoded ); // Rerun
                }

                // Now write
                if( error<0 )
                {
                    // Attempt to resume if suspended for some reason
                    if( snd_pcm_state(playback_handle_)==SND_PCM_STATE_SUSPENDED )
                    {
                        /* Whydidthishappenhere? */
                        snd_pcm_resume( playback_handle_ );

                        if( snd_pcm_state(playback_handle_)==SND_PCM_STATE_SUSPENDED )
                        {
                            // Saving sessions?
                            LOG_ERROR( *logger_ ) << "snd_pcm_resume did not clear the suspended state.";
                        }
                    }
                    else
                        LOG_ERROR( *logger_ ) << "snd_pcm_writei error: " << snd_strerror( error );
                }
            }

            // Empty the payload
            payload_size = PAYLOAD_EMPTY;

        } // If we don't have enough let it slide and unlock
        else if( current_audio->done_ ) // Were we issued a flush?
        {
            // We are done with this loop
            break;
        }
        else
        {
            current_audio->wait_buffer_.wait( buffer_lock );
        }

    } // End while( true )

} // End lock context

As a side note, I've been trying to look a bunch for some lightweight C++ code concerning buffering and playing streaming audio, but haven't found one yet. I'm just missing something somewhere.


Wonderful home In Anchor Hill Ranch sitting on 7.77 acres. *( This home also has another 7.06 acres available for sale for an additional $41,500. ) All of your cares can wash away as you drive down the winding asphalt drive to your new home. This offers a 4 car garage. From the Grand staircase as your walk thru the front door, gorgeous hardwood floors and spacious rooms. You can find a place to sit, relax and enjoy the country views. There could be 6 - 8 bedrooms, (possibly 1 non conforming) 5 baths, office, formal dining, hearth, family room and much more. With the full apartment on the top floor there are so many ways to use top floor in this house. It could be in-law quarters, quest house, dorm for teen?


Warren Stantin has a reputation for being quick and cunning in his apprehension of criminals. However, when a murder suspect leaves the city, Stantin must pursue him in the unknown wilderness. To help him navigate the mountains, he hires a tracker named Jonathan Knox who also has a past with the suspect, and the two soon discover that the suspect has joined a hiking group who is only a small distance ahead of Stantin and Knox. They must race to catch up and figure out who the killer is before it's too later.


ICYMI, Daniel (or Dan, as Sofia calls him) has been racing for around seven years now, and he's even been able to compete internationally.
Who wouldn't want an Instagram boyfriend like Dan, right?
The actress posted a photo with Daniel on IG and captioned it with, "Before, I used to feel so awkward when I see couples just sitting down in the corner, holding hands, girls resting [their] head on their boyfriend's shoulder, and all the sweet gestures. Now, I feel like it's just really normal and it feels amazing to be with someone you're really comfortable with, no matter what. Even like when you're just sitting down staring at each other and especially eating ice cream."


I am rather ashamed of myself. Some poor soul, caught in terminal despair, threw themselves in front of a train just north of Euston yesterday. The whole network was closed down. No trains in or out. I was trying to get back home after a family funeral. I couldn't help but notice how my personal frustration seemed selfishly more important than the despair and death of this person I had never met. I hung my head.
Thousands of people rushed to find other trains out of London. I got to Marylebone where a seriously crowded platform of people used their elbows and anything else to hand to get on a slow train heading north. I wriggled as far as I could up the platform and found a tiny space just inside a pair of doors as they closed.
The crowd inside the carriage slowly adjusted itself and I settled myself for two hours of standing and being jostled. About 20 feet from me was a heavily pregnant woman; also standing and being jostled. I noticed gratefully that it was a 'Quiet Carriage". But I could see too that it was a 'cross carriage'.
People were more irritated to be crammed in than they were to be grateful to be on a train at all.
I knew what I ought to do. I ought to call out in a loud (but non-threatening) voice to ask if there was anyone in the coach willing to give up their seat to a pregnant woman. I think five years ago, I would have done it without a further thought. But now I hesitated. What if my rather chronic eyesight misled me and she was heavily overweight and not pregnant after all? I would be humiliating her instead of helping her.
If I raised my voice in a crowded and cross carriage, even with the intention of asking for help for a pregnant women, would someone somewhere experience it as a hate crime?
How high was the proportion of snowflakes in this carriage? Even as I told myself this was rationally stupid, I realised that the months and years of propaganda had got to me. I was no longer sure that the public I was part of shared my ethical priorities.
The train drew into a station, and the woman seated in front of me, looked up, and indicated she was about to leave. There were about 4 of us in unpleasantly close proximity to her, but she chose to offer to offer me her seat. I said, "thank you, but I can't accept it – can you offer it to the pregnant women down the aisle over there." "Heavens", she said, going red, "I never even saw her- can you get her attention"?
Well then it did get embarrassing. The pregnant lady was determined to keep the new 'no eye contact in public rule.' I had to slowly raise my voice to get her attention. Luckily the people next to her prodded her and smiled genially, pointing at me, standing guarantor for sanity and safety.
"We've got a seat for you if you want it" I shouted. Not all the other bystanders were pleased as she, and her vulnerable womb, pushed and pulled her way through the crowd. She looked as surprised as she was tired, as she was grateful.
And the train continued; the carriage still crammed and cross, and I wondered why the chivalry and the courtesy that would have been normal in my childhood and until recently was so problematic today.
I thought it had something to do with the difference between the French and Russian Revolutions and Christmas. Each stand for different ways of changing our behaviour.
This politically correct 'equality' stuff, with its roots in left wing revolutions, is all about making, forcing, even shaming people into behaving differently, and then redistributing power.
And if you get the words wrong, (people of colour) or send out a University Christmas wish for a 'white campus this Christmas' (shame on white privilege everywhere you supremacist), or don't think changing the age-old definition of 'marriage' will have good outcomes (you fascist bigot), you need to be very afraid, because if you don't change, 'they' will try to make you change.
If the PC equality revolution worries you at all – slip along to a church at midnight on Christmas Eve, and find out how real light and real love pierces human darkness; how a revolution of loving and being loved in your soul is not only better for you, but more effective help for a wounded world.


text:
Lady Saw "Walk Out" In Stores April 17th
/ February 8, 2007 / Leave a comment
Her Story: 10 years deep, 8 albums strong, Jamaica's bad gyal says goodbye to VP Records on Walk Out (2007), her final and finest album up to date on the independent label. The Grammy winning artist still remains true to her sexually empowering, no-holds bar dancehall lyrics, but she is entering the next chapter of life and is ready to address those often-ignored and important issues for females. Plaguing over 25 millions females, Lady Saw opens up about her personal struggles with infertility on 'No Less Than A Woman,' the inspirational hit swarming the airwaves of Jamaica and beyond. She talks about the media hype, stigmas attached and how she overcomes these battles. 'World's Prettiest' is another uplifting ballad that rejects all idealistic beauty standards and reiterates the importance of beauty within.
Singles: 'Me & My Crew', 'Chat To Mi Back' and 'No Less Than A Woman (Infertility)'
Artist Collaborations: Rap Artist, Remy Ma (I-Tunes exclusive track)
Myspace Page: www.myspace.com/ladysaw
Bio: See Below!
LADY SAW: WALK OUT
"My Level right now is untouchable, my spot can't be taken! It doesn't matter who comes and who goes, they are not my problem."- Lady Saw
Her voice resonates far beyond the rough ghettos of Jamaica, Lady Saw, Dancehall's First Lady, is inarguably the wickedest female Deejay to ever rock the mic. Her audacious delivery, cocksure style and no nonsense attitude, has garnered Mama Saw an admirable position on reggae music's food-chain; a spot that has been untouchable since the release of her first LP on VP, Lover Girl (1994). A Dancehall pioneer and one of the most distinguishing images in both hip-hop and reggae. 10 years deep, 8 albums strong, Jamaica's bad gyal says goodbye to VP Records on Walk Out (2007), her final album on the independent label. The risqué hit maker's self proclaimed best work to date. "I'm in love with this one, it's hot in every way" says the 30 something St. Mary's native in a delightful British seasoned Jamaican accent. "I'm singing about a lot more positive things and revealing a side of me that people never knew I had." And with Triple Platinum status and Grammy under her frock for her collaboration with No Doubt on "Underneath it All," and the ability to consistently headline shows all over the world (whether she has current chart topping singles or not), Lady Saw, born Marion Hall, remains true to her raunchy sexual ego, while demonstrating a mature, not often explored, emotional side that ultimately authenticates her diversity as an musician. She's a Songtress, Deejay, Producer, Writer and most importantly, a Woman that has managed to garner tremendous success in a fickle, male-dominated industry. Simply put, her longevity reveals that true artistry always stands the test of time.
Walk Out is a 14 track collectable that wholeheartedly speaks to every single Lady Saw follower. Whether it's the pat-your-front woman anthems that she's notorious for ("Power of Pum Pum," "Walk Out") or the rugged street tracks that win her credibility amongst the thugs ("Me and My Crew," "Chat to Mi Back") Mama Saw delivers a perfect Raw blend on Walk Out. On the Roach produced tune, "Chat To Mi Back," Saw advises haters', When you see mi man/ gal don't violate…any day you feel you can rush this/ you and ya friend dem gang up and touch this…chat to mi back/chat to mi back/ cause this a body that a gal' cant knock. The punany lyricist also heats up things on "Me and My Crew (Roach)," preaching…"My crew push the hottest ride…mi and mi friends have the hottest guys. We make dem know wah name bling…introduce them to the finer things…tennis bracelets and diamond rings." Both records are currently mashin' up the streets of Jamaica.
Lady Saw, mama to three adopted children, takes listeners to a more sensitive place when her very personal epics are revealed on songs like, "No Less Than a Woman," which is currently a lead single in Jamaica and more importantly, an inspirational ballad for infertile women. Not having a child does not make me no less than a woman/ Cause I've got so much love to give/ So much unwanted kids/ Say all you want about me/ Try to ruin mi reputation/ I still have got so much love to give. "People feel if you can't breed or get pregnant, then you must not be a real woman," says Saw. "But they are not God. If I keep loosing the babies and never have a child of my own, then God knows what's best." The legendary Sly & Robbie produced "World's Prettiest" is another grown up, Mama Saw track, where she vividly creates a lyrical expose of women's psychical insecurities, in an image driven society. "I wrote this song to uplift women who are not in love with themselves," says Saw. And she does nothing less than remind vulnerable woman, I'm not the worlds most prettiest but I turned out fine…I wasn't born with a pretty face and I don't have a super model shape…but I'm beautiful so I walk with grace; preaching, "Love what God's created," the track's important subliminal message.
Saw produced a handful of songs on her exit album (You Need Me, No Less Than A Woman, Baby Dry Your Eyes), adding to the hefty resume that includes previous production for A-list reggae artist, Beenie Man, Sizzla, Bounty Killer, Capelton and Spragga Benz. At the height of her career, mainstream appeal resulted in dynamic collaborations with Gwen Stefani, Missy Elliot, Remy Ma, Foxy Brown and Pharrell Williams, reiterating, for what she refers to as "hurry come up" talent (rookies), that Mama Saw is a confident veteran that fully understands her craft. Lover Girl (94'), Give Me The Reason (96'), Passion (97'), The Best Of Lady Saw (97'), 99 Ways (98') and Strip Tease (04') all uniquely contributed to the personal maturity and spiritual growth that enabled Marion "Lady Saw" Hall to "Walk Out" and leave her footprint in Reggae music forever.
Tiffany Mea
VP Records Publicity
89-05 138th St.
AIM: VPTIFF
PH: (718)-425-1151
Donald Wilt created the group Marketing Is Often A Long-Term Investment 1 day, 1 hour ago
Donald Wilt became a registered member 1 day, 9 hours ago


text:
module ApplicationHelper

  def title(page_title)
    content_for(:title) { page_title }
  end

  def head(text)
    content_for(:head) { text }
  end

  def javascript(*args)
    content_for(:head) { javascript_include_tag(*args) }
  end

  def page_scripts(&block)
    content_for(:page_scripts, nil, &block)
  end

  def set_page_focus(css_id)
    set_page_focus_or_activate(css_id, 'focus')
  end

  def set_page_focus_and_activate(css_id)
    set_page_focus_or_activate(css_id, 'activate')
  end

  def clear_both
    "

"
  end

  def on_load_scripts(&block)
    page_scripts do
      <<-JS

      JS
    end
  end

  def button(size, color, markup)
    content_tag(:span, markup, :class => "btn btn-#{size.to_s}-#{color.to_s}")
  end

  def hide_if(condition)
    " style='display:none;'" if condition
  end

  def hide_unless(condition)
    hide_if(!condition)
  end

  def toggle_element(*element_ids)
    update_page do |page|
      page.toggle *element_ids
    end
  end
  alias_method :toggle_elements, :toggle_element

private

  def set_page_focus_or_activate(css_id, focus_method)
    on_load_scripts do
      "$('#{css_id.to_s}').#{focus_method}();"
    end
  end
end

redpajama_set_name: RedPajamaGithub


text:
Matt, a former Sergeant with 23 years of service with the Eastham Police Department on Cape Cod, Massachusetts, retired and moved to Maine in 2002 with wife Ginny. They live in Parkman where they own and operate Bucks Crossing, a lodging and guide [...]
Matt, a former Sergeant with 23 years of service with the Eastham Police Department on Cape Cod, Massachusetts, retired and moved to Maine in 2002 with wife Ginny. They live in Parkman where they own and operate Bucks Crossing, a lodging and guide service.
Matt was first licensed in real estate in 1988 in Massachusetts and then in 2006 in Maine. Matt and Ginny enjoy the outdoors and all it has to offer. Matt is a Registered Master Maine Guide and a Licensed Coast Guard Charter Captain. In his pursuit of enjoying all that Maine has to offer, Matt finds great satisfaction in helping others find that special place in Maine.
With his real estate and outdoors experience, he has learned that the two go hand and hand.
Matt will work tirelessly to accomplish your goal of finding what you want. He invites you to visit www.realtyofmaine.com Give Matt a call today to discuss your real estate needs.
"Everything went as well as it possibly could. A few things came up, but nothing that was Matt's fault. We would absolutely refer Matt to everyone." Nov 2016
"The sale went very smoothly. Matt is a very nice guy. We listed at the end of last year, going into winter, but once the weather got better, the buyers came out. I would most definitely refer Matt to others in Maine." Oct 2016
"Matt was great to work with and did a very good job for me. I really enjoyed doing business with him and was happy with the price. I would certainly recommend Matt to anyone." Oct 2016
"Everything went just fine. Matt was invaluable when it came to all the extensions we had to go through. He took care of all that and we did not have to do a thing. I would certainly recommend Matt to others." August 2016
"Matt did an outstanding job for me. He is very thorough, probably a trait he brings from his former law enforcement career. He has a way of making you feel rest assured. He takes charges, covers everything and makes it happen. I have already referred Matt to something else and will continue to do so." JAN 2016
"Matt was an absolute joy! I love the home and am as happy as can be." JAN 2016
"Matt did an absolutely wonderful job for me. He was personable, knowledgeable and went out of his way for me. He put everything into this. It was not just another listing to him. I felt like he was really working for me. A superb job. Very pleased and would refer Matt to everyone." JAN 2016
"Great working with Matt and Ginny. We had to do this from CT, so we really counted on them. Ginny took some great photos and Matt was great with everything we needed. We were very pleased and look forward to working with them on another property." Jan 2016
"I had no issues at all with Matt. He was very helpful in dealing with a lot of difficulties with the seller. We would definitely refer Matt to all." Oct 2015
"Matt is the best Realtor® I have had the pleasure of knowing in quite some time and I have worked with several over the past 2 years. He was straight-forward, honest and told it let it is. He was a HUGE help to me and I have already referred him to someone else. I can't wait to show Matt what I have done with the house." Oct 2015
"Matt was very informative of the market and regularly kept in contact with us. We had listed the home with a Greenville agency the year before and they were not responsive, never showed it and did not seem to care whether it sold or not. Matt did exactly what he said he was going to do and he sold it! We were very happy with Matt and would never hesitate to refer him." July 2015
"Everything went fine. Matt kept me informed all along the way and did a very good job for us. I would certainly refer him to anyone." Aug 2015
"Our working with Matt was great. He is a very nice person and always kept on top of things. He kept us in the loop at all times. I would certainly refer Matt to anyone." Aug 2015
Realty of Maine Bangor Office
info@buckscrossingmaine.com
Specialties: Listing Agent, Relocation, Waterfront, Commercial, First Time Home Buyers, Buyer Agent, Recreational Properties, Land, Residential , Farm/ Horse Properties, Niche Properties, Acreage/Land, Homes w/acreage, Commercial Sporting Lodges, Vacant Land
Matthew's Testimonials
Matt was better than the former Realty of Maine agent that I had. I had to ask questions of my agent where I was purchasing as the former agent was not responsive to questions at all. The reason I listed Matt's negotiation and marketing skills low was I really did not see them in action except for the end. Overall I was not very satisfied with Realty of Maine at all. It seems that all they were interested in was making a sale as soon as possible, regardless of what my circumstances were. It [...]
Daniel Pratt
I've been a real estate broker for just under 50 years.....owned the first Coldwell Banker franchise in CT....and now run a COMMERCIAL/INDUSTRIAL brokerage company. I know a great agent when I see one (or choose one)....Matt is simply the best!
David & Virginia Dean
We tried for 6 months to buy a piece of property in Charleston, but there were title problems and neighbor problems and after not getting much help from our Realtor®, we just gave up. Then my daughter found this place in Corinna. We sneaked around looking at it by ourselves and then called Matt's number on the sign. He met us there on Monday and that began a wonderful experience. Matt always answered our questions promptly and was never condescending. He explained the difference [...]
I have personally known Matt for several years. I feel that Matt puts 100% effort into his duties as an agent, to ensure that the client fully understands the process and attains the best possible outcome.
Carl Gottardi II
Matt Young is great! Throughout the whole process, (even when we were just inquiring) he was always responsive. He answered ALL of my questions, email and phone and made the purchase of our land very easy. I will recommend him to my friends and family without hesitation.
Sherril Berry
Lynn 1/8/2016 "Matt did an absolutely wonderful job for me. He was personable, knowledgeable and went out of his way for me. He put everything into this. It was not just another listing to him. I felt like he was really working for me. A superb job. Very pleased and would refer Matt to everyone." THANKS!
Bruce, 1/14/2016 Matt did an outstanding job for me. He is very thorough, probably a trait he brings from his former law enforcement career. He has a way of making you feel rest assured. He takes charges, covers everything and makes it happen. I have already referred Matt to something else and will continue to do so." THANKS!
Gail 1/6/2016 "Great working with Matt and Ginny. We had to do this from CT, so we really counted on them. Ginny took some great photos and Matt was great with everything we needed. We were very pleased and look forward to working with them on another property." THANKS!
Matthew Young's Listings


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Category Archives: In Memoriam
Marianne Wessling-Resnick passed away on November 13th, 2019 after a long and private struggle with breast cancer. She was 61 years old. Marianne was a Professor of Nutritional Biochemistry in the Department of Genetics & Complex Diseases at the Harvard School of Healthin Boston, Massachusetts. A native of the Boston area, Marianne obtained her BS degree in Chemistry from Worcester Polytechnic Institute and a PhD in Biomedical Sciences from UMass Medical School. In 1990, she started as Assistant Professor in the Department of Nutrition at the Harvard School of Public Health, where she moved through the ranks to Professor in 2000. In addition to her research and teaching, Marianne served as a standing member and chair of three consecutive NIH study sections (1998–2012), chair of East Coast Iron Club (1994–1996), co-chair of the FASEB Conference on Micronutrients: Trace Elements (2001), and director of the PhD Program in Biomedical Sciences at the Harvard Graduate School of Arts and Sciences (2010–2014). Marianne's research over the years covered wide territory including biochemical, molecular, and cellular mechanisms of iron transport and homeostasis, manganese transport and neurotoxicity, and endocytic vesicle trafficking. In recent years, she was known throughout the nutritional biochemistry community for her many contributions to our understanding of how iron status and genetic factors regulate iron and manganese uptake via intestinal, pulmonary, and olfactory pathways. Having trained over 30 post-doctoral fellows in her laboratory at Harvard, she was highly regarded as a dedicated and supportive mentor of the next generation of biomedical scientists. As such, she was frequently sought—by junior faculty at Harvard and beyond—for her solid advice on career and life. She seemed to know something about everything, was generous with her time and advice, and despite a strong exterior, she was known by many as a remarkably caring and compassionate individual. She will be dearly missed by hercolleagues and friends at Harvard, the BioIron Society, and the trace element community. Marianneis survived by her husband Paul Resnick and her son Timothy.
Mitch Knutson (University of Florida), Khristy Thompson (Harvard School of Public Health), Jonghan Kim (Northeastern University), and Young-Ah Seo (University of Michigan)
This entry was posted in In Memoriam and tagged Marianne Wessling-Resnick on November 15, 2019 by dsolano.
Prem Ponka (born as Přemysl Poňka) passed away while at a conference in Paris. He was Professor of Physiology at McGill University and Senior Investigator at the Lady Davis Institute for Medical Research in Montreal, Canada. He obtained his MD in 1964 and his PhD (in Physiology) in 1969 from Charles University, Prague. From 1968 to 1979 he served as an Assistant Professor in the Department of Pathophysiology at Charles University in Prague. As Czechoslovakia was then under an oppressive communist rule, he emigrated to Montreal in 1979 under difficult circumstances, and resumed his academic career at McGill and the Lady Davis Institute. While still behind the "iron curtain", Prem developed an interest in the study of iron and heme metabolism and throughout his career continued making major contributions in this area of research. Prem demonstrated that iron uptake is the limiting factor for erythroid heme synthesis. He formulated the 'kiss-and-run hypothesis", according to which iron is directly delivered from endosomes to mitochondria in erythroid cells. He discovered a critical role of the heme catabolic enzyme heme oxygenase in erythroid cell physiology. Furthermore, Prem developed a new class of cell permeable iron chelators (SIH, PIH and analogues), which are widely used by researchers in the field. Prem was an active member of the BioIron Society and organized its first international conference in Prague in 2005. He also organized an earlier "iron conference" in Montebello, Quebec, in 1987. Prem was an acclaimed scientist who received broad recognition for his work, and was in high demand as a lecturer and peer-reviewer of manuscripts and grant proposals in Canada, USA, Czech Republic and elsewhere. He was a devoted colleague with encyclopedic knowledge of the history and personalities of the bioiron field, and a renaissance man with a broad interest in science, history, philosophy and arts. He was a dedicated proponent of political and intellectual freedom and tolerance, with a unique sense of humor. Prem had no plans to retire and passed away as an active scientist, exactly as he envisioned. He is survived by his wife Dr. Jitka Ponka, adult children Dr. David Ponka and Claire Ponka, and grandchildren. Prem will be greatly missed by his colleagues at the BioIron Society, McGill University and the Lady Davis Institute.
Kostas Pantopoulos (McGill University) and Tomas Ganz (UCLA)
This entry was posted in In Memoriam and tagged Lady Davis Institute, McGill University, Prem Ponka on November 4, 2019 by dsolano.
In memory of Leo Richard Zacharski
It was with great sadness that we learned that Leo Richard Zacharski, MD, passed away on August 23, 2019 at the age of 81.
Leo attended Wayne State University and then received his MD degree in 1962 from Wayne State Medical School in Detroit. He served an internship at Harper Hospital in Detroit followed by a residency in internal medicine and subspecialty training in hematology at the Mayo Clinic in Rochester, Minnesota. He served as a Captain in the US Army Medical Corp from 1966 to 1968. He was appointed Assistant Professor of Medicine at Dartmouth Medical School and Staff Physician at the VA Hospital in White River Junction, Vermont in January 1970. He specialized in diagnosis and treatment of patients with bleeding and clotting disease, and also iron overload disease. While early motivations were toward medical missions, the heart of his career was devotion to biomedical research believing that he could best serve humanity through discovery and innovation. He was awarded Research Career Development positions at the VA hospital and became the Associate Chief of Staff for Research there in 1985, a position held until retirement from the VA in 2004. During his tenure with the VA he authored over 250 published papers and over 100 abstracts. He served as Chairman of three National VA Cooperative Studies. He achieved the rank of Professor of Medicine in 1985 and became Professor of Medicine Active Emeritus in 2013. Devotion to his "calling" prompted continuation of his research following retirement. His most productive years followed retirement during which he coined the term, "ferrotoxic disease", referring to diseases of aging caused by oxidative stress due to progressive iron accumulation. He was a member of the American College of Physicians, American Society of Hematology, International Society on Thrombosis and Haemostasis, International BioIron Society and East-West Iron Club; and served on the Medical Advisory Board of the Iron Disorders Institute (irondisorders.org). His personal Christian faith prompted deep appreciation of the elegant intricacy and beauty of the "natural order" which was the basis for his devotion to biomedical research.
Xi Huang, Ph.D.
This entry was posted in In Memoriam and tagged Leo, MD, Richard, Zacharski on September 23, 2019 by dsolano.
Laying Down a Solid "Iron Foundation": Professor Erica Baker
Erica Baker (2018)
A dedication to Erica Baker will appear in an upcoming Special Issue of Biochimica et Biophysica Acta specifically on cellular and molecular mechanisms of iron metabolism. The dedication, written by Des Richardson, is posted in its entirety below.
This special issue of Biochim. Biophys. Acta is devoted to the study of the molecular and cellular mechanisms involved in iron metabolism. It is especially dedicated in memory of Professor Erica Baker (Figure 1) of the Department of Physiology, University of Western Australia, Perth, Australia.
Erica was a true pioneer in the field of cellular iron metabolism, having contributed substantially to the understanding of the role of endocytosis in the internalization of iron from transferrin in erythroid cells and hepatocytes. She was a co-worker of Winthrop Professor Evan Morgan in seminal studies that have had a lasting influence in understanding cellular and molecular mechanisms involved in iron metabolism.
As a pertinent example of Erica's studies is the reprint in this issue of a landmark article that was originally published in Biochim. Biophys Acta in 1969, which examined whether the mechanism of iron uptake from transferrin was energy-dependent using metabolic inhibitors [1]. At the time, and even for many years later [2, 3], there was much controversy as to whether iron was released at the cell surface, or was actively transported into cells via an energy-dependent mechanism involving receptor-mediated endocytosis after transferrin became bound to the transferrin receptor 1.
Studies by Erica and Evan were landmarks in the field, and unlike others who used cell lines of doubtful physiological significance, they implemented primary cultures of physiologically-relevant cell-types (reticulocytes and hepatocytes) to define the role of endocytosis in iron and transferrin uptake. In later years, her attention turned to the development of iron chelators for the treatment of iron-loading diseases and cancer [4, 5]. As such, her investigations have contributed to a burgeoning field in pharmacological research assessing chelators for the treatment of neoplasia and other diseases.
Erica received First Class Honours in Physiology and her PhD degree in 1970. She then spent her post-doctoral career at Kings College, London, working with eminent scientists in the field, including Professors E. Huehns and A. Tavill. She returned to the University of Western Australia in 1978 to a highly prestigious appointment as one of few National Health and Medical Research Council (NHMRC) Fellows in Perth.
Significantly, Erica was funded continuously by the NHMRC for 28 years until her retirement in 2007, by which time she was an NHMRC Senior Research Fellow. Apart from being a passionate and dedicated research scientist, she was an incredible friend and mentor, who supported the development of many careers in the field, including my own.
Unfortunately, Erica was afflicted by a crippling neurological condition, which she fought bravely for many years, while raising three highly successful children, and continuing her research work at the very highest level.
The current special issue serves as a tribute to her pioneering achievements and outstanding mentorship in the field that has laid down a solid, "iron foundation", for others to build upon.
Des R. Richardson B.Sc., M.Sc., Ph.D., D.Sc. (UWA), F.F.Sc., FRCPath (UK)
Professor of Cancer Cell Biology,
NHMRC Senior Principal Research Fellow
Director, Molecular Pharmacology and Pathology Program
Leader, Cancer Cell Biology and Development Theme, Bosch Institute
Medical Foundation Building (K25), 92-94 Parramatta Rd, Level 2, Room 253
University of Sydney,
Sydney, New South Wales, 2006, Australia
Ph: +61-2-9036-3026
Morgan, E.H. and Baker, E. (1969) The effect of metabolic inhibitors on transferrin and iron uptake and transferrin release from reticulocytes. Biochim. Biophys. Acta. 184:442-54.
Baker, E. (1977) In: Iron metabolism, Ciba Foundation Symposium 51, New Series, p367, Elsevier, Exerpta Medica, North Holland, Amsterdam.
Richardson, D.R. and Baker, E. (1994) Two saturable mechanisms of iron uptake from transferrin in human melanoma cells. The effect of transferrin concentration, chelators and metabolic probes on transferrin and iron uptake. J. Cell. Physiol. 161: 160-168.
Baker, E., Richardson, D.R., Gross, S. and Ponka, P. (1992) Evaluation of the iron chelation potential of hydrazones of pyridoxal, salicylaldehyde and 2-hydroxy-1-naphthylaldehyde using the hepatocyte in culture. Hepatology 15: 492-501.
Richardson, D.R., Ponka, P. and Baker, E. (1994) The effect of the iron(III) chelator, desferrioxamine, on iron and transferrin uptake by the human malignant melanoma cell. Cancer Res. 54: 685-689.
Figure 1: Professor Erica Baker in the cell culture suite at the Department of Physiology, University of Western Australia.
This entry was posted in In Memoriam and tagged 2018, Baker, Erica on July 23, 2018 by dsolano.
Peter Geisser (1945 – 2018)
The 'Iron Man' of Vifor Pharma
The late Dr Peter Geisser was a key figure on the St Gallen site for over 40 years. First, as apprentice, then as research leader, later driving the research effort for more than 20 years and finally, after retirement, becoming the company's consultant and scientific expert. It is not an exaggeration to say that Vifor Pharma would not be what it is today if it had not been for Peter Geisser. Etienne Jornod, Executive Chairman, likes to point out, Vifor Pharma is a pharmaceutical company "based on nothing but water, sugar and iron". The fact that we have been able to build a global specialisation on a foundation of three apparently unpromising commodities owes a huge debt to Peter's passion, intellect, perseverance, discipline and mastery of his subject.
One of Peter's first big breakthroughs was on Maltofer® in the 1970s. Fresh from his doctoral thesis on complex metal chemistry, he was assigned to develop a chewable tablet formulation. In the process, he and his team were also responsible for standardising Maltofer® to provide the product consistency that we have today. Interviewed for the product's 40th anniversary, Peter was passionate about his favourite subject of safe and effective iron delivery. "It is a fantastic opportunity to be able to treat iron deficiency. People everywhere – particularly women and children – need something better than conventional oral iron preparations. We have something better – and it is very hard to copy because iron complex chemistry is very difficult. There are millions of possibilities for creating a solution. It's like playing chess. You have to think how to put things in the right sequence to win."
Throughout his career, Peter was a tireless champion for iron therapy. Back in 1991, parent company Galenica had been all set to get rid of the Hausmann-Vifor iron products. It was Peter's unshakable belief – and Etienne Jornod's faith in Peter – that saved them. More than quarter of a century later, our portfolio of iron-based products treats millions of patients around the world. Our story would have been very different without him.
Transforming ideas into successful products
Part of Peter's success lay in the fact that his approach was always firmly rooted in a clear definition of patient need. Talking in recent years about the development of Ferinject®, he recalled, "The idea for a new i.v. iron product came from feedback from clinics. There was evidence of adverse effects and dose limitations with existing products on the market. Most patients with anaemia need between 1,000 and 1,500 mg iron. The need to develop a new i.v. iron product was obvious. It had to be able to be administered quickly and at high doses and have as few adverse effects as possible." So began an exhaustive three-year process to synthesize and test over 1,000 molecules to arrive at ferric carboxymaltose, the active ingredient of Ferinject®. It then took another five years of work to prove that this formula met our high expectations for efficacy and side effect profile.
Peter could also be highly creative. Head of Chemical & Analytical Development Erik Philipp was a long-time colleague. He remembers accompanying Peter on a visit to B.Braun back in 1994. On the table, a deal to manufacture a phosphate binder for dialysis patients. During discussions, it emerged that B.Braun's substance was too expensive for oral use so that was the end of the project. Far from being discouraged, Peter was stimulated by this set-back. "We spent the train trip home brain storming about how we could manufacture such a preparation more cost-efficiently. By the time we got off the train, we had the basis for developing Velphoro®, our own phosphate binder that is now marketed in many countries, including the US and EU." It was a typical example of how Peter could transform ideas into successful products.
A sense of ownership
Throughout his career, Peter was totally committed to 'his' people and products. His strong sense of ownership, combined with a decisive and forthright character, meant that if Peter felt something needed doing, he did it. St Gallen Site Manager Hans-Martin Müller remembers how, in his first year with Vifor International as Production Manager, he took few days' holiday in Amsterdam. At the time, some researchers – including Peter Geisser – stuck to strict research parameters that were much narrower than the official specification. While he was away, Peter shut down production; Hans-Martin returned to find 15 operatives with nothing to do!
One of Hans-Martin's first responsibilities in 1999 was to codify the manufacturing process to comply with increasing and more demanding regulations. Peter, of course, was the main source of information, but at that stage, much of it was still in his head, so he took the time to commit his knowledge to paper, creating the site's production 'bible'. Hans-Martin also recalls that Peter had a hard time being tactful with so-called 'experts'! "It took him a little while to realise you can't tell an FDA inspector he's wrong!"
Having retired in 2010, Peter still worked around two days a week as the company's consultant and scientific expert. He remained until the end an invaluable source of knowledge on all things iron, giving input for presentations, contributing to books and papers, always happy to help with answering questions for registrations. He was an excellent company ambassador, speaking at industry events and, for many years, his talks were a highlight of visits to St Gallen. Hans-Martin remembers, "Peter had a gift for convincing people with demonstrations and easy-to-understand experiments. In his white lab coat, with his bushy hair and infectious enthusiasm, he really looked the part of the crazy scientist! And he was always pleased to do it."
With more than 70 publications and 20 patents to his name, Peter Geisser has left his mark on iron chemistry, iron therapy and parenteral nutrition. And he has left an enduring mark on his friends and colleagues around the world, inside and outside the company. His informed mind and incisive delivery will be missed. If you are visiting St Gallen, you will notice that the wall of the staircase in the new packaging facility has been painted with people's silhouettes. Among them, the unmistakable outline of Peter in his lab coat, peering into a flask: every inch the researcher. As he would no doubt wish to be remembered.
A life in research…
1961-1965 Laboratory technician apprenticeship with Hausmann Laboratories in St. Gallen
1965-1968 Chemical Engineering degree from the Ingenieurschule, Winterthur' Switzerland
1968-1972 PhD in Chemistry at the University of Fribourg, Switzerland
1972-1974 Post Doctorate in Organic Synthetic Chemistry at the University of Bern
1974-1986 Leader, Synthesis and Galenics, R & D Department, Hausmann Laboratories, St. Gallen
1986-1989 Head of R & D, Hausmann Laboratories Inc., St. Gallen
Vice-director from 1987
1989-1992 Scientific Expert and Head of the new Hausmann/Vifor Chemistry and Biochemistry
1991-1992 Member of the Executive Board of Hausmann Laboratories
1992-2001 Head of Research and member of Vifor International Executive Board
2001-2006 Scientific Director and member of Vifor International Executive Board
2006-2008 Head of R&D, Scientific Director and member of Vifor International Executive Board
2008-2010 Scientific Director of Vifor Pharma, Vifor International
2010-2018 Consultant and Scientific Expert
This entry was posted in In Memoriam and tagged 2018, 'Iron Man', Peter Geisser, Vifor Pharma on July 20, 2018 by dsolano.