Opalescence Boost is a 40% power whitening gel for medical in-office use only. It is applied by the dentist for whitening one or more teeth, parts of a tooth, and/or for accelerated chairside whitening techniques. Opalescence Boost is also used on nonvital teeth, including in-office intracoronal bleaching.
Opalescence Boost is an alternative, conservative method for treating dark, internally discolored teeth (compared to crowns, veneers, etc.) caused by disease, injury, or medical treatment such as congenital, systemic, metabolic, pharmacological, traumatic, or iatrogenic factors such as dental fluorosis, jaundice, tetracycline, adult minocycline stains, porphyria, trauma, and erythroblastosis fetalis.
Opalescence Boost can be used alone or in conjunction with other Opalescence tooth whitening treatments.
Scientific studies have proven that the best in-office bleaching results do not require a light. That's why Opalescence Boost has always been chemically activated for the highest quality in-office whitening available.
Offering dramatic results after just two or three 20-minute treatments, Opalescence Boost is perfect for patients looking for instant whitening gratification or those who have an important event coming up that requires a bright, white smile.
Opalescence Boost uses a unique syringe-to-syringe mixing method to ensure fresh, effective product for every application. Once the gel is mixed, Opalescence Boost is conveniently applied to the teeth through the Micro 20ga FX tip. This specially designed tip has flocked fibers on the end to allow quick, easy, and precise delivery.
With its powerful 40% hydrogen peroxide formula, Opalescence Boost can provide noticeable whitening results in less than one hour. Because of its powerful concentration, Opalescence Boost is only administered in the dental office.
The noticeable color of Opalescence Boost makes it easy to see, which helps during placement and removal.
Opalescence products are among the most stable whitening products in the industry, maintaining virtually all of its effectiveness over the course of its shelf life.8,9 Because delivery times vary depending on the location of each particular dental office, Opalescence products are formulated with transit time in mind, so they remain stable even after being shipped across the country. In fact, stability studies performed on Opalescence tooth whitening gels have shown that the peroxide potency at the end of the product's shelf life is consistently 90% or greater.
Many whitening products on the market dehydrate teeth, resulting in uncomfortable sensitivity for patients. Opalescence Boost is made up of 20% water to keep the teeth hydrated during the whitening process. This high water content, combined with optimum levels of potassium nitrate and fluoride, reduce the likelihood of residual sensitivity for your patients.
Because tooth whitening gel can be in the mouth for several hours at a time, it's important to use a product with a pH that closely matches the natural pH of a patient's mouth. When the mouth has a lower pH (between 5.5 and 6.5), bacteria can begin to flourish. Opalescence Boost contains added buffers to help maintain neutral pH levels. So, not only can whitening improve the esthetic appearance of your patients' smiles, it can also provide numerous health benefits for your patients as well.


text:
Q: Accessing API with for-loop randomly has encoding error, which breaks loop in R I'm trying to access an API from iNaturalist to download some citizen science data. I'm using the package rinat to get this done (see vignette). The loop below is, essentially, pulling all observations for one species, in one state, in one year iteratively on a per-month basis, then summing the number of observations for that year (input parameters subset from my actual script for convenience).
require(rinat)

state_ids <- c(18, 14)
bird_ids <- c(14886,1409)

months <- c(1:12)

final_nums <- vector()
for(i in 1:length(state_ids)){
  total_count <- vector()

  for(j in 1:length(months)){

  monthly <- get_inat_obs(place_id=state_ids[i],
                          taxon_id=bird_ids[i],
                          year=2019,
                          month = months[j])

  total_count <- append(total, length(monthly$scientific_name))

  print(paste("done with month", months[j], "in state", state_ids[i]))
  }

  final_nums <- append(final_nums, sum(total_count))
  print(paste("done with state", state_ids[i]))
}

Occasionally, and seemingly randomly, I get the following error:
No encoding supplied: defaulting to UTF-8.
Error in if (!x$headers$`content-type` == "text/csv; charset=utf-8") { :
  argument is of length zero

This ends up breaking the loop or makes the loop run without actually pulling any real data. Is this an issue with my script, or the API, or something else? I've tried manually supplying encoding information to the get_inat_obs() function, but it doesn't accept that as an argument. Thank you in advance!

A: I don't believe this is an error in your script. The issue is with the api most likely.
the error argument is of length zero is a common error when you try to make a comparison that has no length. For example:
if(logical(0) == "TEST") print("WORKED!!")
#Error in if (logical(0) == "TEST") print("WORKED!!") :
#  argument is of length zero

I did some a few greps on their source code to see where this if statement is and it seems to be within inat_handle line 211 in get_inate_obs.R
This would suggest that the authors did not expect for
!x$headers$`content-type` == 'text/csv; charset=utf-8'

to evaluate to logical(0), but more specifically
x$headers$`content-type`

to be NULL.
I would suggest making a bug report on their GitHub and recommend they change the specified line to:
if(is.null(x$headers$`content-type`) || !x$headers$`content-type` == 'text/csv; charset=utf-8'){

Suggesting a bug is usually more well received if you have a reproducible example.
Also, you could totally make this change yourself locally by cloning out the git repository, editing the file, rebuild the package, and then confirm if you no longer get an error in your code.

redpajama_set_name: RedPajamaStackExchange


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Home > General > The Cantina > Endorsement deals going bye-bye?
Endorsement deals going bye-bye?
Author Topic: Endorsement deals going bye-bye? (Read 2720 times)
I'm guessing heavy sponsor-dependent (Auto racing, Golf, etc.) sports are sweating these days. It's going to be difficult for a lot of these companies to justify spending huge endorsement money with their hands out to Congress.
http://www.golf.com/golf/...e/0,28136,1861539,00.html
DETROIT (AP) General Motors Corp. said Monday it is ending its nine-year endorsement deal with golf superstar Tiger Woods as the automaker continues to cut expenses and hoard cash while trying to survive the worst sales downturn in a quarter-century.
The cash-strapped company said in a statement that it is looking to reduce costs, and that Woods also wants more personal time as he expects his second child.
Woods has endorsed GM products around the world and mainly has been seen in Buick commercials as the company tried to give the nameplate a more youthful image.
``I am very proud of the long standing partnership I've had with GM and have enjoyed being a part of the company's dramatic product evolution,'' Woods said in a statement.
GM's statement said the company and Woods agreed together to end the deal, and the separation was amicable.
Re: Endorsement deals going bye-bye?
welcome to PGA sponsorship, McD's and WalMart.
Quote from: Aske on November 24, 2008, 09:44:23 AM
John Daly FTW!
Members Only Jacket
From: Australia
Geez, now poor Tiger is doing it rough.
The good thing about getting old, is that you can hit the ball out of sight.
Quote from: Jules on November 24, 2008, 12:45:04 PM
.......... is doing it rough.
Is it just me........
You have a one track mind Mister.
Quote from: stroh on November 24, 2008, 12:45:51 PM
You do realize that she's *goshdarn* with us, right? Playing all Sandy Olsson innocent when she's really more like Betty Rizzo with her mind in the gutter just like the rest of us.
^Sometimes a train is just a train.
Sponsorship is ALREADY a huge issue in NASCAR, and with teams folding/merging/cutting operations left and right, it could be a tough couple of years. I wouldn't be surprised at all to see a couple of short field (less than 43) races next season, particularly late in the year at Las Vegas and Phoenix, where Southwest Tour teams can no longer just fire a bullet into an existing chassis and run with the big boys.
On the upside, the COT actually HAS reduced operating costs for teams, at least in terms of actual cars on hand. Before, you really needed 10 or more per driver, now that number's down to 4 or 5, and you can probably get by with 3. NASCAR has instituted a 'Testing Ban', but it's lip service more than anything. Teams are still free to test at a track they don't race on, so teams with money will still test at will.
All that said, I think tough times helps separate the wheat from the chaff.
Certain future hall of famer Brent Kaeding said it best:
'Real racers always find a way to race more with less'.
Oh Gleek, I am so glad that you have such a high opinion of me.
If I'm going to be the bad girl, Rizzo is pretty lame, I think maybe Sharon Stone in Basic Instinct.
The sad thing is, no matter how hard I have tried to be bad, I can't.
I'm just a Sandy Olsen at heart.
I can still hear my Irish Catholic Grandmother, telling me I will go straight to hell if.............
It's going to be difficult for a lot of these companies to justify spending huge endorsement money with their hands out to Congress.
You are SO cute. You think these people have shame, like the old timey guys who at used to fade out of sight to die broke and alone on skid row or throw themselves out of a window.
No, we don't do that in postmodern 'IT'SMYMONEYNOWF#CKYOUVERYMUCHLOSERS' 'Merka:
http://wonkette.com/40457...b-things-news#more-404573
Quote from: MFAWG on November 24, 2008, 06:41:47 PM
I'm going to assume you aren't being condescending. I get the fact that you'll always be able to find the pigs but.....along with GM ending Tiger's deal NASCAR is laying off people and the LPGA is cutting back their schedule. Sponsorship money IS tightening up.
No, wasn't being condescending.
There's a thin line between legit marketing expenses and OTT waste.
7 million for one guy (even Tiger) is a little steep. Prolly cuts WAY into the Lear Jet money.
Look mummy
Did did did did you hear the frightened ones? Did did did [i]did[/i] you hear th
Masters Sunday (spoilers)
Bye Bye Justin
Bye, Brother Munson!
Bye, whore! ;D
rickhicks- amazon hddvd sale
http://www.highdefdigest.com/news/show/Industry_Trends/Venturer/Hardware/Venture

redpajama_set_name: RedPajamaCommonCrawl


Three different types of dates.
Malaysia is a multi-cultured socitey, colourful and rich with different races' culture and tradition. Sometimes, things just blur out in between and people like me, sometimes cannot really differentiate which culture/practice 'belongs' to the Malays, which 'belongs' to Chinese, which 'belongs' to Indians. I think I have no qualms in making friends with non-Chinese. In fact, my very good friend is a Malay. But we are both English speaking.
And every year, the Malays, actually the Muslims, have to endure a month of fasting before the celebration of new year. I join them, sometimes for my own religious moments (I'm a Catholic), sometimes for my own personal interests (like when I'm overweight, ) And there is this one food that I like so much that I'm willing to puasa (fast) – dates, or kurma in the Malay Language.
The Chinese use a lot of red dates in boiling herbal tonic. But I've never like them, because of their coarse skin. If the red dates have been soaked in water and plump up, I don't mind but then it is not that juicy and sweet. It is like a red pouch filled with whatever tonic that red date belongs to.
I like these Middle East kurma. I have yet to eat fresh ones that you can pluck from the twig and pop into your mouth. The kurma I have, normally come from the Supermarket during the fasting month. But there are so many different brand names and they come from different countries.
The one that I like most is the rounded type, soft and chewy, moist and succulent.
I was in search of the kurma since the first day of the fasting month. But I didn't have any luck, until yesterday when my good friend's brother in law passed me a box, imported from the city of Bam in southern east area of Iran. Previously, I had bought some from the local supermarket; the oblong-shaped, seedless, crunchy and less sweet types. But they are not moist.
via Let's Get Dates – dLoop.


text:
Q: Cannot do load balancing with NGINX , DOCKER AND Flask - failed connecting to upstream I'm trying to do a load balancing between 2 Flask api handlers with NGINX and docker.
For my nginx.config I have:
upstream my_upstream {
    server 127.0.0.1:5000 weight=6;
    server 127.0.0.1:5001 weight=4;
}
server {
    listen 127.0.0.1:80;
    server_name localhost;
    location / {
        proxy_ssl_server_name on;
        proxy_pass https://my_upstream/;
    }
}

For my docker-compose.yml file I have the following:
version: '3'
services:
  nlp1:
    build: ./NLP_APP
    ports:
    - "5000:5061"
  nlp2:
    build: ./NLP_APP
    ports:
    - "5001:5061"
  nginx:
    build: ./NGINX
    ports:
    - "8080:80"
    depends_on:
    - nlp1
    - nlp2

For my Flask app I did the following config:
if __name__ == '__main__':
    app.run(host="0.0.0.0",port=5061)

When I'm sending a API call I get the following message :
wevoice_flask-nginx-1  | 2022/08/15 13:15:42 [error] 32#32: *2 connect() failed (111: Connection refused) while connecting to upstream, client: 192.168.192.1, server: , request: "GET /invoices/62f7b965bf33d5c5b2dda4f9 HTTP/1.1", upstream: "http://127.0.0.1:5061/invoices/62f7b965bf33d5c5b2dda4f9", host: "localhost:8080"
wevoice_flask-nginx-1  | 2022/08/15 13:15:42 [warn] 32#32: *2 upstream server temporarily disabled while connecting to upstream, client: 192.168.192.1, server: , request: "GET /invoices/62f7b965bf33d5c5b2dda4f9 HTTP/1.1", upstream: "http://127.0.0.1:5061/invoices/62f7b965bf33d5c5b2dda4f9", host: "localhost:8080"
wevoice_flask-nginx-1  | 2022/08/15 13:15:42 [error] 32#32: *2 connect() failed (111: Connection refused) while connecting to upstream, client: 192.168.192.1, server: , request: "GET /invoices/62f7b965bf33d5c5b2dda4f9 HTTP/1.1", upstream: "http://127.0.0.1:5062/invoices/62f7b965bf33d5c5b2dda4f9", host: "localhost:8080"
wevoice_flask-nginx-1  | 2022/08/15 13:15:42 [warn] 32#32: *2 upstream server temporarily disabled while connecting to upstream, client: 192.168.192.1, server: , request: "GET /invoices/62f7b965bf33d5c5b2dda4f9 HTTP/1.1", upstream: "http://127.0.0.1:5062/invoices/62f7b965bf33d5c5b2dda4f9", host: "localhost:8080"

I've been breaking my head on this as running the Flask API standalone with the following API call is working.
GET http://localhost:8080/invoices/62f7b965bf33d5c5b2dda4f9


I'm so excited to have been asked to be a part of the blog tour for THE WIG IN THE WINDOW, a fun middle grades mystery by Kristen Kittscher (a middle school teacher!). I'm especially excited that Kristen offered up a guest post on her revision process (an aspect of the author's writing life I'm looking to share more examples of with my students - and in fact am co-chairing a session about at NCTE in November).
Sophie Young and Grace Yang have made a game of spying on their neighbors, but when they stake out the home of notoriously phony middle school counselor Dr. Charlotte Agford (aka Dr. Awkward), they stumble across a terrifying scene.
I'm so delighted to be continuing my blog tour for The Wig in the Window at Heise Reads & Recommends!
Given the prying nature of my enterprising tween sleuths, Young & Yang, I've been taking you all behind-the-scenes for some top secret investigations into how a manuscript is turned into a real, live book.
If you've been following the tour, you've already investigated what goes intodesigning a cover and gotten some insight into the naming of characters. Today we're getting down to the nitty gritty and taking a look at what goes into the editorial and revision process.
Before I wrote THE WIG IN THE WINDOW, I cursed my own lack of talent. If I were a real writer, I thought, I'd be able to produce tighter, cleaner prose – and I'd be able to do it faster. Though I'd been preaching the importance of getting feedback and revising work to my own students, for some reason I thought my own writing should be better from the get-go. I'd start projects, fall into despair far too early, and toss my work into the trash.
Fortunately, I had not one, but two, fantastic editors at Harper Children's who worked as a team to guide my revisions: Editorial Director Rosemary Brosnan (who edits one of my favorite authors, Rita Williams-Garcia) and Associate Editor Andrea Martin.
They were kind enough to let me share with you some of their notes on an earlier draft of The Wig in the Window. If you read the final product, you'll see just how much their questions and comments improved my work!
First, Rosemary and Andrea collaborated on what's known as an "editorial letter" to outline what was working in my manuscript and what bigger picture story and character problems needed to be addressed.
One challenge in writing a kids' mystery is ensuring the kids are driving the action while those pesky, hovering parents stay out of things! I was so focused on Sophie Young and Grace Yang's sleuthing hijinks that I found far too convenient ways to sideline parents. In an early draft, Sophie's parents were very easily manipulated by the (potentially) villainous school counselor, Dr. Agford. Rosemary and Andrea weren't about to let me get away with that!
Sophie and Grace's families could stand to be developed more. We barely see Sophie's parents, and it's a little hard to believe that they would so quickly accept all of Agford's suggestions. Sophie's parents would understandably be mortified by her behavior, but would they completely cave to Agford?
Uh, nope. They sure wouldn't. My editors were right. To revise, I dove down into my story and tried to see it from my main character's parents' point-of-view. I found a new way to keep them out of the main action and also tried to give more true-to-life interactions with Sophie and Dr. Agford throughout the book. I've gotten a few compliments on the parents in the final version, which always makes me laugh—little does anyone know how bad they'd be without that editorial help!
In their editorial letter, Rosemary and Andrea always provided possible solutions for problems they saw. In most cases, though, I found that I'd discover different "cures" to the symptoms they diagnosed—ones that felt natural to me in the story. Though I agreed with most of their notes, there were always times, too, when I felt I couldn't address them without wreaking too much havoc. We'd talk it out together, then, and decide how I could best work around those flaws.
I just wanted to let you know I'm still alive and working. Everything is progressing normally, which is to say that some days I feel very certain this manuscript is the equivalent of Sophie's turd volcano and others, it spews its fake lava as splendidly as Marisa's Mt. Etna. Assuming neither impression is entirely accurate, I press on.
I then asked if I should be weaving in descriptions of my potential villain's Halloween décor. I had noticed that I point out her love of over-the-top holiday displays throughout the book, but the book takes place at Halloween and I don't mention so much as a pumpkin!
I would go with some Halloween decorations, as they are in character for Agford, they add humor, and it seems counterintuitive that Agford would draw attention to herself that way, as you say. What do you, think, Andrea?
I really like the idea of a smattering of Halloween decorations. They're very much in keeping with who Agford is, and it's also a nice way to set the time period of when the story takes place. And it's another great instance of phony outward appearances!
The first Halloween pumpkins and decorations were starting to pop up. I was surprised Agford's house wasn't fully mummified in fake cobwebs yet. She'd gone so overboard for Flag Day, we were positive she'd hauled out a Ouija board and conjured up Betsy Ross to consult on the project.
There are many things we love about your opening (how Sophie keeps track of summers, for example) but we thought they weren't as critical as the need to keep Sophie and Grace moving forward to Agford's house. If you dearly miss those passages, perhaps we can find a place for them…or you can always save them for a blog post about all the beautiful, witty gems that your editors foolishly asked you to cut.
I couldn't tell you exactly when we started the patrols. Southern California's vague seasons make it hard to track time. To make it easier, I've developed my own system of charting years. It's pretty basic. I remember every year by its summer, and each summer has a theme. For example, my guinea pig Agatha died shortly after the Summer of the Highly Unprofitable Lemonade Stand but before the Summer of Truth or Dare at the Petersons'.
We started spying on our neighbors sometime before the Summer Everyone Started to Shave Their Legs….
Maybe the voice and observations are nice enough, but it was slowing down the action. When supposedly "good writing" is getting away of the story---it's no longer any good!
Hope you enjoyed this little behind-the-scenes investigation – and that you'll take heart the next time you're looking at one of your own messy first drafts of writing. The magic comes in revision.
I hope, too, you'll check out THE WIG IN THE WINDOW to see how the final product turned out! It hits stores tomorrow. Available at your local independent bookstore, Barnes & Noble, or Amazon.
I am SO looking forward to reading your debut and now I want it in my hot grabby hands even more :) Great post!
Fabulous and thoughtful post. I really enjoyed reading about your revisions.
Thank you for participating in the tour! I was really looking forward to this "behind the scenes" post :D The deleted scene reminds me of the Summer We Played Nerf Pool So Much Our Arms Were Buff, aka 1987.
I love the "behind the scenes" look at your beautiful book! Thank you for sharing!
Great post! It truly highlights the important role that editors play. And, I love the rare inside look into the world of an author.
very interesting post. editors are so important. it's true too that i think we are often harder on ourselves and expect more from ourselves than we would of other people. happy boo birthday to the wig in the window!


text:
SPORTS | OTHER SPORTS TRACK
Gators travel to Arkansas for NCAA Indoors
By Kyle Brutman
March 12, 2015 | 8:21pm EDT
Florida's Marquis Dendy reacts after competing in the long jump at the NCAA track and field championships on June 12 in Eugene, Ore. Dendy became the first athlete to win both the long jump and the triple jump at the NCAA Outdoors since 2002.
Photo by AP Photo | The Independent Florida Alligator
For most of UF's student body, Spring Break was a time of relaxation and a time to get away from the stressors that attending school builds on a person. However, for the No. 1/2 Florida men's and women's track and field teams, it was a time of preparation for the NCAA Indoor Championships.
Coach Mike Holloway's squad goes into Fayetteville, Arkansas, with momentum gained from the Southeastern Conference Indoor Championships, where the Gator men came out as conference champs and the women finished runner-up.
While the national meet is of great importance to the state of any college program, Holloway's preparation for his team was just business as usual.
"It's just a track meet. Again, we don't but this big moniker on it," Holloway said. "It's not about the label on the event. … just go out there and compete and do your job."
The Gators will feature 22 individual athletes at the Randal Tyson Track Center this weekend—12 on the women's side and 10 on the men's side.
On the men's side, the most notable events include the triple and long jumps, the 400-meter sprint and the 4x400 relay.
The long and triple jumps will include the duo of Dendy and freshman jumper KeAndre Bates. Dendy is the top-ranked triple jumper in the NCAA and the No. 2 long jumper, while Bates ranks seventh in the long and 12th in the triple.
The 400 will feature the Florida trio of NCAA leader Najee Glass, Arman Hall and Nick Uruburu. Hugh Graham Jr., who qualified for the event, will be sitting out due to an injury.
The tandem of Glass, Hall, Uruburu and senior Dedric Dukes will compete as Florida's section "D" 4x400, racing in a hotly contested heat that consists of Texas A&M and LSU—ranking No. 1 and tied for No. 4 with the Gators, respectively.
On the women's side, the second-ranked Gators' meet is highlighted by the 200-meter sprint and the triple jump—with both events featuring UF athletes.
In the 200, senior Kyra Jefferson, the NCAA leader in the event, and Destinee Gause—ninth in the country—will look to capture the NCAA title in the event. Jefferson claimed the only SEC title for the women in the event last month.
Senior jumpers Ciarra Brewer and Gissell Warner — ranked second and 14th in the event, respectively — will bout with freshman phenom and conference opponent Kenturah Orji of Georgia and the rest of the field for the triple jump national title.
The men will look for its fourth indoor national title, while the women hope to capture its first indoor national title since 1992—the only women's NCAA indoor title in program history.
Follow Kyle Brutman on Twitter @KBrut13


text:
Aviation, Airline & Aerospace(Travel & Tourism)
Cathay Pacific Releases its 2021 Sustainability Report on the Occasion of World Environment Day
New commitments in carbon neutrality and diversity, and supporting communities during the pandemic
The Cathay Pacific Group has released its comprehensive annual Sustainable Development Report that addresses its commitment and progress in the areas of environmental, social and governance, which are of great importance to its stakeholders, and towards its goal of net-zero carbon emissions by 2050.
Regional General Manager, South Asia Middle East and Africa (SAMEA), Rakesh Raicar said, "We continue to ramp up our efforts to fight climate change and have made specific tangible progress towards supporting and prioritising our sustainability issues which are communicated in our 2021 Sustainable Development Report. This includes supporting our communities around the world by transporting essential aid during this global health crisis, and making new commitments towards the use of Sustainable Aviation Fuel (SAF) in our operations. We are certain, together with our partners and customers, we will continue to positively contribute to the environment and communities, and also connect Hong Kong to the world in sustainable ways as recovery accelerates."
Some highlights from the 2021 report include:
• Helping to deliver vaccinations around the world: We raced against time to develop a dedicated Vaccine Solution to make COVID-19 vaccines available to global communities. In 2021, over 165 million vaccine doses along with other essential medical supplies were delivered to Hong Kong and beyond by our airlines.
• Making progress towards carbon neutrality: We became one of the first airlines in Asia to target 10% SAF use by 2030 and have committed to purchasing more than 350 million gallons of SAF beginning from 2024 alongside our oneworld Alliance peers. We also co-founded the Aviation Climate Taskforce, an industry platform through which we will accelerate the development of breakthrough technologies that will help drive the decarbonisation of civil aviation. We also developed Asia's first major Corporate SAF Programme in 2021, which came to fruition in April this year with the launch of its pilot phase, bringing SAF into Hong Kong International Airport for uplift for the very first time.
• Strong commitment to diversity: We have pledged to increase female representation at senior positions by 25% – reaching 30% in total – by 2025. To drive changes, a Diversity and Inclusion (D&I) Steering Committee and a dedicated team were set up in 2021.
PR Category : Travel & Tourism
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According to historical evidence, in 1686, Arang-khan began the construction of the citadel Kunya-ark at the western gates of Ichan-kala. The ark presented a complex multi-yard composition, containing a house for khan, the members of his family, and dignitaries. From the large numbers of constructions of the ark only several buildings of the nineteenth century and the beginning of the twentieth century were preserved. They were the official reception hall (kurinishkhana), a mosque, the mint, and a harem. Previously, there were an arsenal, a powder-mill, and an official building, warehouses, a kitchen, guardhouses, a stable, and a parade area. Fortified gates led to the citadel. A high-cogged wall separated the ark from the neighborhood dwellings of Ichan-kala.
There was an outer yard, serving as a waiting room for the khan's audiences. There were cannons in a second yard. The officials of khan gathered in the third yard, and only then the main door of the kurinishkhana was visible. A felt yurta (nomad tent) was put up for the khan's use. A narrow corridor led to the harem and a staircase led to the Akshikh-bobo mount from here. The two-layered aivan, which was practically merged into the city wall, opened in the direction of the city. This was a good place for an observation post. From here one could see the panorama of the whole city and the neighborhoods. They say that Khiva's rulers liked to rest here on warm nights.
The Akshikh-bobo aivan has also been used for military observation.
The fortress constructions were closely compacted together; their charm can be seen in the yards with their splendid aivans. The high two-column aivan of the kurinishkhana, where receptions were held, completely is faced with majolica. In the eighteenth century during the devastating invasion of the Iranian troops many constructions of the citadel were destroyed, and the kurinishkhana was damaged. At the beginning of the nineteenth century Iltuzar-khan renewed it. There was a throne-hall, khan's apartments, treasury, and manuscript depository. The cold blue-white and sky-blue patterns of the majolica plate contrast with the red murals of the ceiling. The Khiva masters arranged ornaments freely and picturesquely. The interior of the throne-hall is decorated with carved plaster. The throne was made of turned wood, decorated with stamped silver. The local master Mukhammad made it in 1816.
The building of the mint and an asymmetric mosque with an aivan were built at the same time and comprise a single complex. The famous Khiva masters Abdulla Jin and Ibadulla did the majolica facing of the mosque. The ceiling of the aivan is painted with elegant golden patterns on the blue background.
There is a harem, built under Mukhammad Rahim-khan II in the second half of the nineteenth century in the northern part of the citadel. The pillars of the aivans are covered with traditional carved ornaments. Instead of complete majolica facing one can see separate colored ceramic insertions. The walls are decorated with simple plastering and colored brightly.
The Khiva aivans were unique with their elegant decoration. Through skilful carving, stone carving, and decorative ceramics the artists and architects of Khiva expressed their notion of beauty.
Among the preserved architectural monuments is a bathhouse, built in 1657 and devoted to Anush-khan. This is a semi-underground, multi-chambered construction. The system of cupolas covering the building is seen from outside. From the lobby via a cloakroom one can get into the main bathing hall, connected with the arched passages, and into the rest houses, which are around the hot-water pool. There is a reservoir with cold water in the central hall. A system of under floor canals through which hot air passes warms the bathhouse. The efficient technology of the bathhouse, combined with imaginative planning and with simple constructions epitomizes the architecture of the municipal constructions of Khiva.
In the eighteenth century the summer palace of the Khiva khans, Chadra-hovli was built in the suburbs of Khiva. The building consists of four stones. The first of them represents an exclusive two-chamber winter building where there was a stable and a warehouse. The adobe staircase leads up to a second floor, consisting of a dwelling and aivans facing the west and south. The aivans create a view of the environs from the three sides. As one ascends, the weight of the floor and the thickness of the wall are reduced dynamically. Three windows are placed vertically on the northern facade.
The building was erected with adobe blocks, fluting is seen on the facade and the interior is trimmed by plaster. The only element of the decor on the aivans is the carved wooden of the pillars. The Chadra-Khovli is characterized by originality and simplicity.


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Farrag et al., M. (2022). Age and growth of elephant-snout fish Mormyrus kannume (Forsskål, 1775) (Family: Mormyridae) from Lake Nasser, Egypt. Egyptian Journal of Aquatic Biology and Fisheries, 26(5), 219-234. doi: 10.21608/ejabf.2022.260577
Mahmoud M. S. Farrag et al.. "Age and growth of elephant-snout fish Mormyrus kannume (Forsskål, 1775) (Family: Mormyridae) from Lake Nasser, Egypt". Egyptian Journal of Aquatic Biology and Fisheries, 26, 5, 2022, 219-234. doi: 10.21608/ejabf.2022.260577
Farrag et al., M. (2022). 'Age and growth of elephant-snout fish Mormyrus kannume (Forsskål, 1775) (Family: Mormyridae) from Lake Nasser, Egypt', Egyptian Journal of Aquatic Biology and Fisheries, 26(5), pp. 219-234. doi: 10.21608/ejabf.2022.260577
Farrag et al., M. Age and growth of elephant-snout fish Mormyrus kannume (Forsskål, 1775) (Family: Mormyridae) from Lake Nasser, Egypt. Egyptian Journal of Aquatic Biology and Fisheries, 2022; 26(5): 219-234. doi: 10.21608/ejabf.2022.260577
Age and growth of elephant-snout fish Mormyrus kannume (Forsskål, 1775) (Family: Mormyridae) from Lake Nasser, Egypt
Article 14, Volume 26, Issue 5, September and October 2022, Page 219-234 PDF (962.56 K)
DOI: 10.21608/ejabf.2022.260577
Mahmoud M. S. Farrag et al.
The elephant-snout fish Mormyrus kannume is one of the known interesting fish in the most interesting man-made lake in Egypt (Lake Nasser). Due to the global conservatory objectives and lake management, this species won scientific and commercial interest as there were no sufficient or recent studies on this species. The present work aimed to study the growth pattern of the elephant-snout fish (M. kannume) from Lake Nasser, Egypt via length-weight relationship, condition factor, growth in age and growth parameters. A total of 645 specimens were monthly collected from the commercial landing sites (Aswan, Garf Hussein and Abu Simbel harbours) from November 2017 to December 2018. The investigations illustarted a wide range of length from 15.3 to 77.5 cm (TL), with an average of 36.3±7.0 cm and a total weight (W) ranging from 25.2 to 2882.5 g, with an average of 360.3±278.6. The length-weight relationship showed negative allometric growth for males, females, and combined sexes. The absolute condition (Kc) showed a higher value during February (0.74±0.06) for males and during April (0.72±0.06), May (0.72±0.09) and July (0.72±0.06) for females. For C. sexes, the highest value was recorded during February (0.72±0.06). The lower Kc was during August for males, females and C. sex. In general, the conditions were located under "1" along the year and recorded an annual average of 0.68±0.072, 0.69±0.70 and 0.68±0.075 for males, females and C. sexes respectively. By using opercula reading, the life span/ growth rings of M. kannume were calculated as ten years with a mean length of 17.3, 26.64, 35.11, 42.98, 49.56, 55.91, 61.5, 65.82, 69.66 and 72.54 cm TL, for each age groups from one to ten respectively. The von Bertalanffy growth constants were computed as L∞= 89.91 cm TL, K = 0.16 year-1, and to = −0.91. The growth performance index (ϕ) was 3.11 and the longevity of age (t max) was 18.56 years. In spite of the presence of negative allometric growth combined with the lower value of conditions than "1" which may be affected by food and spawning, the others such as aging, growth performance, and age longevity have reflected a satisfied growth pattern in this lake and are valuable for creating a monitoring and management system for M. kannumein Lake Nasser recommending its conservation with require to more studies
Age; Growth; Mormyrus kannume; Mormyridae; Lake Nasser; Egypt


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#These two authors contributed equally to this work.
The death receptor 5 (DR5) is a member of the tumor necrosis factor receptor superfamily that can transduce the apoptosis signal in cells. This study assessed serum levels of soluble death receptor 5 (sDR5) in small-cell lung cancer (SCLC) patients compared with those in healthy controls. Clinicopathological features of patients, treatment responses, and overall survival of patients were also recorded and analyzed. The sDR5 levels were analyzed using ELISA in 50 healthy controls and 82 SCLC patients before and after first-line chemotherapy. The statistical data showed that pre-treatment levels of serum sDR5 in SCLC patients were higher than those of healthy controls (P<0.001). Pre-treatment levels of serum sDR5 were significantly associated with smoking history of patients, Veterans Administration Lung Study Group (VALSG) stage, tumor size, and lymph node (N) metastasis (P=0.028, 0.001, 0.028, and 0.01, respectively). After treatment with the first-line chemotherapy, the post-treatment levels of serum sDR5 were obviously decreased (P<0.001), and correlated with treatment responses (P<0.001), although there was no significant difference in their pretreatment sDR5 levels (P=0.62). Cox proportional hazard analysis demonstrated that the post-treatment levels of serum sDR5, VALSG stage, and PS status were all independent predictors for overall survival of patients. The results from the current study indicate that serum level of sDR5 could be further confirmed as a biomarker to predict treatment responses and survival of SCLC patients.
Lung cancer remains one of the most commonly diagnosed human cancers in the world. Lung cancer can be histologically classified into small-cell lung cancer (SCLC) and non-small cell lung cancer (NSCLC) [1, 2]. SCLC only represents a small portion (approximately 13%) of all lung cancer cases, but it is clinically aggressive and associated with early extrathoracic metastases . SCLC cells contain dense neurosecretory granules along with neuroendocrine hormones that induce endocrine/paraneoplastic syndrome . Although SCLC responds well to chemotherapy , it is frequently diagnosed at an advanced stage thus leading to a poor prognosis . The median survival without treatment is only 2 to 4 months and overall 5-year survival rate is approximately 3-8% [6, 7]. To date, platinum- and etoposide-based chemotherapy is the first-line treatment [8, 9], but tumor recurrence and metastases lead to a dismal prognosis . Therefore, a search for novel therapeutic strategies or biomarkers for early detection and prediction of prognosis and treatment responses could lead to better control of this deadly disease.
Tissue homeostasis is the balance of cell proliferation and death (apoptosis) , while tumor development and progression are characterized by an increase in cancer cell growth and evasion of tumor cell apoptosis [12, 13]. Tumor necrosis factor (TNF)-related apoptosis-inducing ligand (TRAIL) is a member of the TNF superfamily that can induce tumor cells to undergo apoptosis [14-16]. Activated TRAIL binds to the death receptor and subsequently induces caspase activation and cell apoptosis [14-16]. To date, five death or decoy receptors have been discovered that bind to TRAIL: death receptor 4 (DR4 or TRAIL-R1), DR5 (or named as TRAIL-R2), DcR1 (TRID/TRAIL-R3), DcR2 (TRAIL-R4), and the soluble receptor osteoprotegerin . DR5 can transduce the apoptosis signal in cells [18, 19], but DR5 overexpression has been indicated in several types of human cancers, including colon, lung, cervical cancers and head and neck squamous cell carcinoma [16, 20-24]. Another previous study showed that the endoplasmic reticulum (ER) stress induced DR5 transcription and apoptosis in colon cancer HCT116 cells , although soluble DR5 (sDR5) levels were upregulated and significantly associated with poor prognosis of patients with NSCLC . Thus, in this study, we first assessed serum sDR5levels in SCLC versus healthy controls, investigated the clinicopathological features of SCLC patients, and predicted treatment responses and overall survival of patients. We sought to provide insightful information regarding sDR5 as a biomarker to predict treatment responses and overall survival of SCLC patients.
In this retrospective case-control study, we obtained serum samples from 82 SCLC patients (47 males and 35 females) who underwent treatment in Shandong Provincial Qianfoshan Hospital (Jinan, China) between January 2010 and April 2013. All patients were histologically or cytologically confirmed as SCLC cases; however, any patients who received surgery were excluded from this study, while patients receiving any previously systemic therapy within 6 months were also excluded. The SCLC patients were staged according to the Veterans Administration Lung Cancer Study Group (VALSG) staging system  and all patients were required to have a dimensionally measurable disease through chest radiograph or computed tomographic (CT) scanning. The patients were randomized to receive standard (up to 6-cycle) treatment with etoposide and cisplatin (EP) or etoposide and carboplatin (CE), with or without radiotherapy. The therapeutic dose was adjusted according to each patient's physical condition. Patients were followed up regularly with physical examinations, blood chemistry analysis, ultrasound examination of the abdomen, X-ray or CT scanning of the chest, brain CT or MRI, and scintigraphy of the skeleton.
In addition, we also collected blood samples from 50 healthy controls who visited our hospital for annual health check-ups and who were matched to the SCLC cases by age and gender. The study was approved by the Ethics Committee of Shandong Provincial Qianfoshan Hospital and written informed consent was obtained from each patient.
All patients received up to 6-cycle randomized treatment with EP or CE with or without radiotherapy and were followed up regularly. The tumor response was measured using the Response Evaluation Criteria In Solid Tumors criteria  4 to 6 weeks after completion of all therapy, which includes complete response (CR, no residual tumor lesions), partial response (PR, more than one-third smaller in tumor lesion), stable disease (SD, no change in tumor lesion) and progressive disease (PD, increase in size of tumor lesion).
These patients were followed up regularly and the last follow-up was conducted on July 1, 2018. We then calculated the overall survival (OS) of each patient, which was defined as duration (months) from disease diagnosis to death or to the patient's last visit. The initial recurrence was categorized as loco-regional recurrence or distant metastasis, depending on location of the recurred tumor lesion.
Serum level of sDR5 was assessed by using a solid phase sandwich ELISA kit (cat. #IB-17792; Jianglai Inc., Shanghai, China) according to the manufacturer's protocol. Our preliminary experiments assessed the detection range of 2-70 pg/ml of sDR5 and the A450 value was used to draw the standard curve to normalize the level of sDR5. The ELISA was in duplicate and repeated at least once with similar results.
Serum sDR5 level was summarized as mean ± standard deviation. Difference between two groups was analyzed by using Student's t test. The Kaplan-Meier curve was used to plot overall survival and the log-rank test was performed to generated p values stratified by sDR5 levels. The Cox's regression model was used to analyze independent predictors for overall survival of these patients against different clinicopathological features and serum level of sDR5. The receiver operating characteristics (ROC) curve was used to analyze the cut-off values of serum levels of sDR5 in patients with SCLC and healthy controls, while the area under the curve (AUC) was also evaluated. A p value <0.05 was considered statistically significant. All statistical analyses were performed by using SPSS v13.0 software (SPSS Inc., Chicago, IL, USA).
Among these 82 SCLC patients, there were 47 males and 35 females with a median age of 55 years old. Forty-three patients were ever tobacco smokers and 39 never smokers, while 48 patients were at LS-SCLC and 34 at ED-SCLC stages, and approximately half of these patients (n=40) had lymph node metastasis of SCLC. Most patients (n=62) received EP chemotherapy and radiotherapy (n=71). After therapy, 59 patients had CR or PR, whereas 23 patients had SD or even PD (Table 1). The median follow-up duration of these patients was 12 months (range between 3 and 33 months), while the median OS was 10 months, with 13 months for LS-SCLC patients and 8.5 months for ED-SCLC patients.
Serum levels of sDR5 were compared by Student's t test or the analysis of variance. Results are presented as the means ±standard deviation.sDR5, soluble death receptor 5; VALSG, Veterans Administration Lung Cancer Study Group staging system; LS-SCLC, limited-stage small-cell lung cancer; ED-SCLC, extensive-stage small-cell lung cancer; EP, etoposide+ platinum; CE, etoposide + cisplatin; CR, complete response; PR, partial response; PD, progressive disease; SD, stable disease.
The pre-treatment levels of serum sDR5 in SCLC group were 18.95 ± 4.80 pg/ml, compared with 10.89 ± 6.72 pg/ml in the 50 healthy controls, indicating that the pre-treatment levels of serum sDR5 were significantly higher in SCLC patients than that of the healthy controls (P<0.001; Figure 1A). However, the level of serum soluble DR5 was downregulated after treating the patients with chemoradiotherapy (18.95 ± 4.80 pg/ml vs. 13.54 ± 3.75 pg/ml, P<0.001; Figure 1B).
Changes in serum levels of sDR5 in SCLC patients vs. healthy controls or pre-and post-treatment. (A) The blood samples were obtained from 82 SCLC patients and 50 healthy controls and then subjected to analysis of sDR5 levels using the ELISA. P<0.001 analyzed by using and Student's t test between SCLC and healthy controls. (B) Association of pre- and post-treatment levels of serum sDR5 in SCLC patients, P<0.001 using Student's t test.
We then plotted the ROC curve to assess the cut-off value of pretreatment serum sDR5 levels and found 14 pg/ml as the cut-off value for high vs. low levels of serum sDR5. We then associated sDR5 expression with clinicopathological characteristics from SCLC patients. Our data showed that there was no association of sDR5 expression with age (P=0.44, Figure 2A), gender (P=0.207; Figure 2B), or performance status (PS; P=0.073). However, serum sDR5 level was significantly associated with smoking history, VALSG stage, tumor size, and SCLC lymph node metastasis (Figure 2).
After treating patients with chemoradiotherapy, the objective response rate (CR + PR) was 72% (59 out of 82 patients) and the non-response rate (SD + PD) was 28% (23 of 82 patients). We then associated serum sDR5 levels with treatment response and found that post-treatment levels of serum sDR5 were significantly associated with treatment responses (P<0.0001; Figure 3A); however, there was no significant association between pre-treatment level of serum sDR5 and treatment responses (P=0.62; Figure 3B).
We also performed the univariate and multivariate analyses to predict prognostic predictors for OS of these patients. Our univariate analysis data showed that the performance status, VALSG stages, N stage, post-treatment level of serum sDR5, and tobacco smoking were all prognostic predictors for OS of these patients, while our multivariate analysis demonstrated that the performance status, VALSG stages, post-treatment level of serum sDR5, and tobacco smoking were all prognostic predictors for OS of these patients (Table 2). However, the pre-treatment level of serum sDR5 was not associated with the OS of these patients (Table 2).
We also associated the post-treatment level of serum sDR5 with OS of these SCLC patients using the Kaplan-Meier curves and the log-rank test and found that the reduced post-treatment level of serum sDR5 was associated with better OS of these SCLC patients (Figure 4).
Association of pretreatment serum levels of sDR5 with clinicopathological characteristics from SCLC patients. (A) Pretreatment serum level of sDR5. It compares <55 years vs. ≥55 years patient age groups, P=0.44. (B) Pretreatment serum level of sDR5. Male patients vs. female patients, P=0.207. (C) Pretreatment serum level of sDR5. Patients with PS0-1 vs. PS2-3, P=0.073. (D) Pretreatment serum level of sDR5. Patients with never-smokers vs. ever-smokers, P=0.028. (E) Pretreatment serum level of sDR5. Patients in LS-SCLC vs. ED-SCLC groups, P=0.001. (F) Pretreatment serum level of sDR5. Patients with tumor size of <3 cm vs. ≥3 cm, P=0.010. (G) Pretreatment serum level of sDR5. Patients with lymph node metastasis vs. none lymph node metastasis, p=0.01. PS, performance status; LS-SCLC, limited stage small-cell lung cancer; ED-SCLC, extensive stage small-cell lung cancer; LNM(+), lymph node metastasis positive; LNM(-), lymph node metastasis negative; VALSG, Veterans Administration Lung Study Group.
Association of pre- and post-treatment levels of serum sDR5 in SCLC patients. The blood samples were obtained from 82 SCLC patients before and after treatment and then subjected to analysis of sDR5 levels using the ELISA. (A) Association of post-treatment levels of serum sDR5 in SCLC patients, with responders vs. non-responders, P<0.0001 using Student's t test. (B) Association of pretreatment levels of serum sDR5 in SCLC patients with responders vs. non-responders, P=0.62 using Student's t test.
CI, confidence interval; HR, hazard ratio; PS, performance status; VALSG, Veterans Administration Lung Cancer Study Group staging system; sDR5, soluble death receptor 5.
Kaplan-Meier curves stratified by the post-treatment levels of serum sDR5. The blood samples were obtained from SCLC patients after treatment and then subjected to ELISA analysis of sDR5 levels. To prepare the Kaplan-Meier curves, we selected the cut-off value of sDR5 point at 14 pg/ml according to the receiver operating characteristics analysis of 14 pg/ml. P<0.0001 analyzed by using the log-rank test.
SCLC remains a deadly disease, even after decade-long advancements in early detection and improvement of treatment options [29, 30]. In the current study, we found that the serum soluble DR5 level was upregulated in SCLC patients compared with that of the healthy controls. Thus, future studies with prospective patients could verify our current data so that serum sDR5 level could be used as an effective biomarker to assess the treatment responses and prognosis of SCLC patients.
Apoptosis is a mechanism in multicellular organisms to maintain homeostasis; for example, it is believed that children between 8 and 14 of age lose approximately 20 to 30 billion cells a day due to apoptosis . Apoptosis is a controlled process whereby cell shrinkage, nuclear fragmentation, chromatin condensation, and chromosomal DNA fragmentation are controlled by gene expression and activation through both intrinsic and extrinsic apoptotic pathways [12-16]. The TRAIL and TRAIL receptors can directly induce apoptosis of tumor cells through activation of the cell surface death receptors, while preserving normal cells [32, 33]. The TRAIL-DR5 apoptosis pathway was shown to play an important role in regulation of cell apoptosis  and associated with cancer development and progression [15, 16] as well as showed clinical significance of DR5 expression in human cancers. For instance, DR5 expression was independent prognostic indicator in bladder cancer and associated with better responses to treatment of patients .
Nuclear and cytoplasmic DR5 expression predicted survival of NSCLC after chemotherapy , whereas high DR5 expression was associated with worse disease-specific survival of renal cell carcinoma patients . The pretreatment level of serum sDR5 was higher in NSCLC patients than that of healthy controls, but the post-treatment level of serum sDR5 failed to predict treatment responses or progression-free survival of these NSCLC patients . In our current study, we confirmed high levels of serum sDR5 in SCLC patients versus healthy controls. Our data also demonstrated that serum sDR5 was able to predict treatment responses of SCLC patients. All of these studies, including our own, demonstrated opposite effects of DR5 expression on cancer progression and the treatment responses. Thus further studies are needed. Overexpression of DR5 in cancer tissues could be due to fast-growing tumor cells lacking an appropriate blood supply, resulting in tumor cell death through induction of either apoptosis or necrosis and leading to increase in upregulation of apoptosis-related proteins.
In our current study, we identified 14 pg/ml as the cut-off value for high versus low levels of serum sDR5. Depending on the sample size and sensitivity of each ELISA, this cut-off value could vary; therefore, a future study with a large sample size could confirm our current data. Furthermore, the cellular origin of the increased serum sDR5 level is unknown. A previous study speculated that there was an association between sDR5 secretion and proliferation of tumor cells . In our current study, we found that pretreatment level of serum sDR5 was associated with smoking history, VALSG stage, tumor size, and SCLC lymph node metastasis, indicating that increase in serum sDR5 level could be from tumor cells. Furthermore, our current data demonstrated that serum level of sDR5 was able to predict OS of SCLC patients, although proper detection of sDR5 levels in SCLC has not yet been established.
In conclusion, our current study revealed a predictive value of serum sDR5 level in SCLC patients. However, a multi-center study with a large sample size will be required to validate our current data before sDR5 can be used clinically as a prognostic and predictive marker for SCLC.
This work was supported in part by grants from The Medical and Health Science and Technology Development Plan of Shandong Province (#2017WS790, #2015WS0213), the Natural Science Foundation of Shandong Province (#ZR2016HQ50), and the National Natural Science Foundation of China (#81301868).


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What Happened to Tickle in Moonshiners? — He's out of Jail!
Steven Ray Tickle Is out of Jail — But Is He on Season 7 of 'Moonshiners'?
Earlier this year, Moonshiners star Steven Ray Tickle, known simply as Tickle on the Discovery Channel reality show, was released from jail. However, he's not back on the hit series just yet.
Last year, Tickle was found guilty of possessing an illegal firearm — a sawed-off shotgun in the cab of his truck. He was originally given a three-year suspended sentence, but was arrested again for violating his probation, and sentenced to five months in jail. At the time of his first arrest, Tickle said, "I am a law-abiding citizen. That gun is something that a buddy of mine gave me many years ago."
Fast forward to 2017, and fans saw him leave prison looking plumper than usual. His first stop? To eat a hearty meal. "You know what I'm ready for? Bacon," he told co-star Tim Smith before ordering a BLT sandwich. "I eat eggs all the time sitting up in jail, I don't want no eggs."
He continued, "It's been a long part of my life doing bad things. Eventually, it put me in a place I didn't want to be in. And I'll tell you what, if I keep going the way I am, it's just not going to work. There ain't no place I can go but forward." Tickle also opened up about how hesitant he was to return to his line of work.
"I don't even know about going back out in the woods," he admitted. "Back in the woods, making moonshine. I am seriously thinking of not doing that because I just don't want to go back to where I was at. I got to find another direction to go." Tickle has yet to make an appearance on Season 7 of Moonshiners, and according to his bio, "Tickle will be spending this moonshine season on the sidelines. Once his legal matters are resolved, he will return to his rightful place making moonshine in the backwoods of Virginia." Tune in to Moonshiners on Tuesday nights at 9 p.m. EST on the Discovery Channel.
'Moonshiners' Star Josh Owens Hints at How He Lost His Finger!


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L'uomo senza volto (The Man Without a Face) è un film del 1993 diretto e interpretato da Mel Gibson, ispirato ad un romanzo di Isabelle Holland.

Trama
Boston, fine anni sessanta. Il tredicenne Charles Nordstadt detto "Chuck" vive con la madre divorziata quattro volte e le due sorellastre. Suo padre, alcolizzato e insano di mente, ha abbandonato la famiglia e si è suicidato in un ospedale psichiatrico.

Trascurato in famiglia, Chuck tenta il riscatto decidendo di iscriversi alla prestigiosa accademia militare di West Point, la stessa che aveva frequentato suo padre. Per entrarci deve superare un difficile esame e così chiede aiuto a Justin McLeod, un ex insegnante con la parte destra del volto sfigurata e altre ustioni sul torace, che vive solo ed emarginato da tutti in una sorta di villa-castello nel Maine.

Justin McLeod accetta di diventare il suo maestro così i due diventano amici e iniziano a frequentarsi.

Il volto sfregiato dell'ex professore Justin McLeod è fonte di chiacchiere malevole da parte degli abitanti del villaggio, anche se nessuno sa che cosa sia successo. Così un giorno, McLeod confessa a Chuck la verità: il suo volto è stato sfigurato a causa di un incidente stradale che ha anche provocato la morte di un suo studente. Chuck svela a tutti che cosa è successo e quando la madre scopre che Chuck prende lezioni dal professor McLeod, lo accusa di aver molestato Chuck; nel villaggio infatti si è sparsa la voce che l'incidente sia stato causato dal fatto che McLeod stesse molestando il suo studente mentre erano in auto.

Chuck si confronta aspramente con McLeod, il quale confessa di non aver mai molestato lo studente morto, benché sia stato condannato a tre anni di carcere per omicidio colposo. Rinnovandosi le accuse di pedofilia McLeod non può più frequentare Chuck e i due smettono di vedersi, nonostante Chuck continui a volergli bene.

Finita l'estate, Chuck riesce a superare l'esame grazie agli insegnamenti di McLeod e un giorno fugge dall'Accademia per andare a trovarlo ma scopre che questi ha lasciato la sua casa, lasciandogli una lettera di ringraziamento e una promessa di amicizia eterna.

Quattro anni dopo, Chuck si diploma con ottimi voti e, mentre festeggia con gli altri studenti, riconosce sullo sfondo una figura che si allontana: Justin McLeod.

Produzione
Le riprese del film si sono svolte quasi interamente nel Maine (con qualche scena ripresa nella Columbia Britannica in Canada) dal 3 agosto al 9 ottobre 1992.

Distribuzione
Il film uscì negli USA il 25 agosto 1993 e in Italia il 5 novembre. Gli incassi sono stati di circa 25 milioni di dollari nel mercato nordamericano.

Riconoscimenti
 Nomination ai Young Artist Awards 1994
 miglior film drammatico per la famiglia
 miglior attore giovane in un film drammatico (Nick Stahl)
 miglior attrice giovane in un film drammatico (Gaby Hoffmann)

Collegamenti esterni

Film drammatici
Film diretti da Mel Gibson

redpajama_set_name: RedPajamaWikipedia


text:
Chloroplus is a genus of spur-throated grasshoppers in the family Acrididae. There is at least one described species in Chloroplus, C. cactocaetes.

References

Further reading

Melanoplinae
Articles created by Qbugbot


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10 hidden problems you'll face fixing up an old house
Rachel Ogden
09 April 2020 | 4 Comments
If you've fallen for a heritage home, it's important to be aware of the potential pitfalls. Here are the key problems to look out for, plus what they'll cost to put right...
Who hasn't been tempted by a fixer-upper? Even the savviest buyer can be swayed by a bargain price and bags of potential.
However, old houses are prone to problems, so it's important to know what to look out for and how any underlying issues might affect your budget. Before you sign on the dotted line, you should always arrange for a surveyor to look over your property so you know what you're letting yourself in for.
READ MORE: 10 warning signs that you're looking at a money pit
Here are the most common hurdles you're likely to face in your renovation journey...
1. Leaky roof
Surprise, surprise, old houses often have old roofs, so unless it's been replaced, you may well be facing a deteriorating roof that's no longer watertight.
From the outside, tell-tale signs that it may be leaking include missing or cracked tiles/shingles, loose flashing (this directs water away from seams or joins on the roof), crumbling cement and sagging gutters.
Inside, look for moisture in loft insulation, water stains on the floor and rotten timbers, plus inspect the underside of the roof for cracks of daylight.
While replacing a few tiles or a metre of flashing can cost about £200 – best left to a roofer – structural repairs could cost anywhere between £1,000-£2000, with an entire replacement amounting to £5,000-£12,000, according to My Builder.
2. Inefficient heating
Even if your house has a sound roof, there may be issues elsewhere resulting in a draughty, cold interior. Poor or no insulation in the attic, uninsulated gaps between the foundations and floorboards and no cavity wall insulation can all be underlying causes.
However, even once they're fixed with new or additional insulation and air leaks have been filled, an old radiator system can struggle to warm the house effectively.
You may need to replace the boiler (from £2,500 plus according to Which?) or fit pipes for underfloor heating (this distributes heat more evenly and efficiently than radiators), which Nu-Heat estimates at around £800 for a room measuring 20m².
3. Unsafe electrics
Old electrics can be vulnerable to faults and can pose a serious fire hazard in the home. Look out for dated fuse boxes, plug sockets and faded light switches to get an idea of their age.
A house survey in the UK doesn't include an electrics check, so to determine what work is required, have an Electrical Installation Condition Report (around £150-£300) by a qualified engineer or electrician carried out. A full re-wire involves taking up floorboards and installing wiring in walls, so do this at the start of a renovation.
Electrical tasks aren't a DIY job unless you're experienced, plus partial or full rewires need to be signed off by the local authority if you're not a licensed contractor, so it's best to use a registered electrician.
A full rewire of a three-bedroom house can cost between £2,500-£4,500, according to Household Quotes.
4. Plumbing issues
Water leaks can cause significant damage, so it's important to get a professional to check for any potential plumbing problems.
If your house was built pre-1970s in the UK or pre-1986 in the US, it may have lead pipework or use lead solder to join copper pipe fittings. If this is the case it will need to be replaced, ideally with plastic or copper.
Find where the water pipe enters the property (usually the internal stop tap) and check the colour – lead is dark grey or black but will turn silver when lightly scraped.
While brass and copper pipes can last more than 50 years, you may also find rusted pipework or connections that are worn or poorly repaired. Along with leaky faucets, these will need replacing.
If your property includes trees, check if any pipework has been damaged by roots, especially the sewage system. While you can do small jobs such as replacing taps, new pipework is a job for professionals.
Home Advice Guide says the average price for an entire system using copper pipes in a four-bedroom semi-detached house is around £13,954, rising to £20,117 for steel pipes.
5. Draughty windows
While it's tempting to swap out draughty single-glazed windows for modern units, in an older house, try to repair, rather than replace.
If you live in a listed building or Conservation Area, regulations as to what can be modified often apply, even down to the paint – check with your local authority if you need Listed Building Consent (LBC).
Even if your home isn't listed, replacing timber-framed windows can cause more problems than it solves. Lightweight PVCu frames, for example, may not be strong enough to support the weight of the masonry, making panels difficult to open or cracking the glass.
Instead, check frames for any soft areas that can indicate rot, apply a fungicide if necessary, and replace sections with new timber or resin. If the building has sash windows, a specialist company can replace damaged parts.
Draught sealing and reconditioning sashes costs between £200-280 per sash, with replacement double-glazing working out at around £750 per pair, according to supplier Sash Window Specialist.
6. Mould, damp and mildew
A consequence of excess moisture and poor ventilation, damp, mould and mildew can be caused by anything from leaking pipes to cracked render. If you suspect these issues are present, the first thing to do is determine the source.
Examine the exterior from the top down, checking the chimney, flashing and roof, followed by the soffit (the underside of the roof that extends beyond the building) and eaves (the roof overhang).
If they're damaged or decayed, they may not be directing rain away from the building effectively. Broken or corroded downpipes can also make walls damp.
Next, look at the window frames – damage here can let large amounts of water in. You may also find cavity walls filled with debris, allowing moisture to reach the interior, causing rising damp.
Inside, typical signs of damp include stained walls, peeling wallpaper, rotten timbers and crumbling plaster. The cost to remedy damp can range from minor repairs to a new damp-proof course, which Household Quotes estimates at £2,000 for a detached house.
7. Dry rot
Dry rot occurs when timber becomes damp and fungus that decays the wood has colonised it. In an older house, this means either the wood that was used to build it wasn't kiln-dried (and had a high moisture content) or there's been a damp problem.
Resolving the damp issue doesn't stop the dry rot, so once it's in window frames, doors and floorboards, it's important to take steps to remove it.
Affected wood can be home to greyish cotton wool-like strands or rusty/white patches, a well as suffering shrinkage, but a common symptom is a musty smell. The wood will still be hard, unlike wet rot, which makes the timber soft.
If you suspect dry rot, request a full home survey. Depending on where the rot is, it can cost around £2,000 for a professional removal and thousands more in repairs, says Axa.
8. Hazardous materials
Asbestos was only banned in 1999 in the UK and in the late 1980s in the US so the chances of finding it are high – even if it's not in insulation, it can be in Artex ceilings, flue pipes, floor tiles and eaves, gutters and garage roofs.
Left alone, there's little risk, however, problems arise if it deteriorates or is disturbed during renovation and particles are released.
If you suspect its presence, contact a licensed removal firm who will take a sample or use a DIY kit to test it. Depending on the size of the area, removal costs can range from a few hundred pounds to over £2,500, according to Household Quotes.
You may also find lead paint, which is a neurotoxin if ingested or inhaled. The age of your home is a good guide – if it was built pre-1960s or pre-1978 in the US and there are original coats of paint, there could be lead present. Thick paintwork is another clue, which suggests lead in the older layers.
The easiest solution is to cover and seal it with modern paint. If it's in a poor condition, it should be removed. To do so, wear protective clothes, gloves and face masks and use a solvent or liquid stripper.
9. Foundation and structural issues
Spotting the signs of structural issues in an older house could be the difference between a problem that's easily fixed and one that spirals into an expensive issue.
While small cracks may occur after small alterations as masonry resettles, zig-zag cracks could indicate subsidence – when the foundations (which tend to be shallower in older properties) start to give way. Sloping floors are another indicator of this.
Underpinning is the go-to solution – digging down to stabilise the foundations by filling the hollow area with concrete, however, you may be able to resolve the problem by laying new brickwork under an unsupported wall. A more modern solution is resin polymer injections into the affected ground, which can be less invasive.
Average costs for underpinning range from £10,000-£18,000 says MyJobQuote, and in most cases you'll need to consult a structural engineer, costing £50-£90 per hour.
10. Old chimney
A chimney adds character but it can come with complications, especially if you plan to get it in working order again. If your house has shifted over time the bricks may be broken, while extreme weather can slowly make a chimney crumble.
In this case, it'll need regular upkeep to prevent it from deteriorating further. However, if you plan to use the chimney you'll need to get it lined and have it swept to remove debris and blockages, preventing dangerous gases from leaking back into the room.
The flue lining is an approved fire-resistant material that improves the flow of gases and protects the masonry. Homebuilding & Renovation estimates that a flexible flue liner should cost around £400-£600 excluding installation.
READ MORE: How to renovate an old house – a beginner's guide to fixer-uppers
Featured image: K.M.Williamson/Shutterstock


Dysuria is a topic covered in the 5-Minute Clinical Consult.
Stephens, Mark B., et al., editors. "Dysuria." 5-Minute Clinical Consult, 27th ed., Wolters Kluwer, 2019. Medicine Central, im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688101/all/Dysuria.
Dysuria. In: Stephens MB, Golding J, Baldor RA, et al, eds. 5-Minute Clinical Consult. 27th ed. Wolters Kluwer; 2019. https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688101/all/Dysuria. Accessed April 19, 2019.
Dysuria [Internet]. In: Stephens MB, Golding J, Baldor RA, Domino FJ, editors. 5-Minute Clinical Consult. Wolters Kluwer; 2019. [cited 2019 April 19]. Available from: https://im.unboundmedicine.com/medicine/view/5-Minute-Clinical-Consult/1688101/all/Dysuria.


According to Author Anne Louise Gittleman parasites are not only a Third World Country problem any longer. The rate of parasite-related dis-eases has increased exponentially due to international travel and agricultural trade. Protecting yourself from the side effects of parasites may prove to be very beneficial for your long term health. This cleanse contains a blend of botanic extracts that have a long history for supporting a healthy intestinal tract.
Kit Instructions will be emailed to you once you place your order.


text:
Federation of Hellenic Medical Societies of North America
Medical Conference 2020
Telemedicine Workshop
Global Hellenic Medical Teleconference on COVID-19
Events from Member Organizations
First Global Hellenic Medical Teleconference on COVID-19 Review
The First Global Hellenic Medical Teleconference on COVID-19 on Saturday, June 20, 2020, 10:00 AM - 1:00 PM New York Time, organized by the Federation of Hellenic Medical Societies of North America in collaboration with the General Secretariat of Greeks Abroad and the Hellenic Medical Society of New York was a great success.
Dr. Spyros Mezitis, MD, Ph.D., President of the Federation and endocrinologist at New York-Presbyterian Hospital and Lenox Hill Hospital in New York City moderated the meeting. Professor Emeritus John Chrysoulakis, General Secretary of Greeks Abroad of the Hellenic Ministry of Foreign Affairs, was instrumental in putting the teleconference together.
One hundred physicians from 25 countries, including many University Professors and physicians from several hospitals and 10 Presidents of Hellenic medical societies from around the world, participated.
The Greek Prime Minister Mr. Kyriakos Mitsotakis prefaced the teleconference with the good news of Greece controlling the pandemic and opening to tourism. He invited all doctors and bioscientists of Hellenic descent.to Athens, Greece next summer at a Global Hellenic Medical Conference.
The Deputy Minister of Greeks Abroad, Mr. Kostas Vlasis, University Professor and orthopedist and member of the Greek Parliament congratulated the Hellenic doctors for being at the forefront of the battle against COVID-19 and for their support for Greek issues.
The Governor of Attica and President of the Medical Society of Athens, Dr. George Patoulis spoke on the importance of the global networking of physicians of Hellenic descent.
The speakers and the discussants of international acclaim were exceptional and showcased the power of Hellenic physicians on the world stage.
The Greek American Dr. George Yancopoulos, Chief Scientific Officer of the large pharmaceutical company Regeneron presented the novel genetic method of developing humanized antiviral antibodies in mice that are being used in experimental studies to block COVID-19 action on human lung cells.
Dr. Stefanos Kales, Professor of Occupational Health at Harvard Medical School reviewed the spread of COVID-19 in the United States and its deadly impact on nursing home residents. He analyzed the effect of several factors including climate/temperature, population density, and timely protective measures in controlling the COVID-19 pandemic. He appeared optimistic about the gradual decline of the pandemic and the reduction of COVID-19 mortality.
Dr. Manolis Kogevinas, President of the Barcelona Institute of Global Health presented data on the initial failure of controlling the pandemic in Spain and the subsequent control measures. He noted that the pandemic has moved to countries/continents of weak health systems and problematic hygienic conditions such as South America and Africa. He concluded that the protection of biodiversity will prove a critical factor in future pandemic prevention.
Dr. Sotirios Tsiodras, Harvard trained Professor of Infectious Diseases at the University of Athens, Greece, and Chief of the Hellenic Center for Disease Control, spoke on the successful control of the COVID-19 pandemic in Greece through early lockdown, strict adherence to protective measures, increase in hospital ICU beds and population discipline. He questioned the effectiveness of the vaccines under development and how acceptable they will be by the general population. Dr. Tsiodras believes that tourism with testing and social tracing will be successful.
Dr. Spyros Zakynthinos, Professor of Pulmonology and Intensive Care Medicine at the University of Athens and Chief of the ICU at Evangelismos Hospital in Athens presented slides showing lower 39% mortality compared to other hospital ICUs globally that he believes is due to Greece's early lockdown.
Dr. Theoharis Theoharides, Professor of Pharmacology/Immunology at Tufts University, Boston, Massachusetts commented on his work in controlling the COVID-19 cytotoxic storm.
Dr. George Dangas, Professor of Cardiology at Mt. Sinai School of Medicine and Past-President of the Hellenic Medical Society of New York commented on recent studies associating COVID-19 infection with heart disease.
The neurosurgeon Dr. Demetris Sigounas, Professor at George Washington University, noted that we will be seeing more cerebrovascular events in patients who have suffered from COVID-19 infection.
The interventional cardiologist Dr. Elias Iliadis, President of the Federation of Hellenic Societies of New Jersey spoke on the networking of Hellenic physicians worldwide and the successful management of the COVID-19 pandemic in Greece.
The surgeon Dr. Panagiotis Manolas, President of the Hellenic Medical Society of New York spoke about the contributions of the Hellenic Medical Society of New York physicians in informing and helping the Greek American community to confront the COVID-19 pandemic and in establishing an e-platform for Hellenic professional organizations to communicate and collaborate globally.
The gynecologist Dr. Lorraine Chrysomallis, Vice President of the Hellenic Medical Society of New York (HMS NY) announced the continuing medical education program with COVID-19 tele lectures featuring Dr. Coritsides and Dr. Tassiopoulos on Friday, July 3, 2020, at 8:30 AM New York Time. Other HMS NY doctors who have presented in the media include Dr. Ann Kolokathis, Dr. Andrew Glyptis, Dr. George Syros, Dr. Elias Iliadis, Dr. George Dangas, Dr. George Tsioulias, Dr. Helen Gouzoulis, Dr. George Liakeas, Dr. John Stathopoulos, Dr. Vasilis Latoussakis, Dr. Nicholas Mezitis, and Dr. Spyros Mezitis.
Dr. Kyriaki Sonidou, President of the Hellenic Medical Society of the United Kingdom greeted all teleconference participants and commented on Greek physicians at the front line of the COVID-19 pandemic in Great Britain.
Dr. Marinos Pirpiris, President of the Hellenic Medical Society of Australia thanked the teleconference organizers and presented the COVID-19 situation in Australia.
Dr. Alexis Theodorou, President of the Hellenic Medical Society of Rheinland/Westphalen in Germany, commented on the COVID-19 situation in Germany and plans to visit Greece in the summer.
Dr. Olga Sarantopoulou, President of the Austrian Society of Hellenic Professionals and Entrepreneurs and Vice- President of the Hellenic Medical Society of Austria congratulated Professor Emeritus John Chrysoulakis, Secretary-General for Greeks Abroad of the Ministry of Foreign Affairs and Dr. Spyros Mezitis, MD, Ph.D., President of the Federation of Hellenic Medical Societies of North America for this seminal initiative to bring the Hellenic physicians together worldwide to network and collaborate, exchange views in order to help Greece. She noted that this undertaking should continue on a global basis and that Hellenic scientists must participate in the future policy planning for Greece.
Conclusions of the First Global Hellenic Medical Teleconference on COVID-19 include:
The Hellenic physicians and bioscientists are at the forefront of research and management of COVID-19.
The Hellenic physicians and bioscientists globally are a great asset for supporting Greece.
All speakers agreed that protective measures including strict hygiene, social distancing, and wearing masks when in proximity in closed spaces are imperative in controlling the spread of COVID-19.
The Hellenic medical organizations were successful in communicating globally in order to collaborate in saving human lives.
Greece is working hard to provide a safe environment for Greeks from Abroad and tourists visiting the country.
The Organizing Committee for the First Global Hellenic Teleconference greatly appreciates the exemplary technical support, Dr. Elias Iliadis of the Federation of Hellenic Medical Societies of North America and Ms. Alexandra Demetriou, MS Microbiology, Boston who assisted from the United States.
Copyright © 2020 Federation of Hellenic Medical Societies of North America. All Rights Reserved.


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