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text:
Gabbie Flowers and the Key to the Universe
by Dianne Caplin
System Programmer
by Jean-Philippe Janssens
The Blue Witch
by Alane Adams
Radioactive Revolution
by Richard I Hummel
Finding Your Coach
by Melinda J. Kelly
The Little Light
by Dipa Sanatani
Adventures of Beatrice
by H.C. Herman
A Portrait of the Entrepreneur As a Young Man
by Bob Epstein
SHOCKED SILENT
by Judith Driscoll
Crowning Glory River's Journey
by Taylor Thompson
The Orichalcum Rod
by Travis Pearson
Anything is possible if you believe in God. Anna was a scientist, one of many. She was merely Anna, a child conceived but not born of humans, brought up in an institution and brainwashed by the same institution. That is until she latches onto a...
Reluctant to Wed
Arranged Marriage Series
By Anneliese Dalaba
Reluctant to Wed is the story of Emma, a young girl who left her farm home in Pennsylvania to travel to England and live with a grandfather she has never met. An arranged marriage has been set up for her and she is soon to...
By Sarah Yasin
Retreat House by Sarah Yasin is a fiction thriller about a young woman, Holly, running a youth group to bring the youth of her congregation together. With the plans made to have a co-sleepover at Holly's uncle's old lake house, parents begin to take their...
Ride the Sky
By Murray Pura
Ride the Sky is an Amish romance novel written by Murray Pura. David Lapp had been courting Tabitha Reimer for over a year before he finally decided to take her out to a special place and ask her to be his wife. That Saturday had...
By Mandy Lawrence
Inspiring and poignantly written, Replay by Mandy Lawrence is a romance that explores what it takes to make a relationship succeed against the odds. When rookie receiver for the Carolina Panthers, Derek Holder, marries Abby, it seems like a fairy tale to her. But things...
River of Fire
By Darrell Case
Life can be very difficult, sometimes challenging not only one's concept of what's fair, but also one's faith. Victoria grew up with her aunt in Chicago. Hoping for a better life than slaving as a seamstress, Victoria takes up teaching in a small town. Little...
(Faith Under Fire Trilogy, Book 3)
By Gwen Sutton
Restored by Gwen Sutton is a wonderful crime thriller that explores the extent to which sex trafficking can affect individuals and their families, a final entry in a gripping trilogy revolving around a single family. When child sex trafficking victim, Dereka Jones, decides to stop...
Reflections from the Creek
By Stephen Payseur
Reflections from the Creek by Stephen Payseur is the story of Stephen and his friend, Josh. The two meet again and this time they talk about religions and Stephen discovering himself. Stephen believes that these meetings are coincidental from his side, but maybe Josh premeditates...
Rebel's Trap
By Randall Jarmon
I just put down Rebel's Trap by author Randall Jarmon, and all I can say is "Wow." This book was a rip-roaring read from the very first page. Protagonist John Travis is living an extremely difficult and dangerous life. There aren't too many people that...
By Corbin Bernsen
Rust by Corbin Bernsen was a truly poignant and deeply human drama. Rather than relying on special effects, fantasy, or sizzle to deliver a plot, Rust's quiet narrative lays open the vulnerabilities and frailties of the very ordinary. Hero James Moore grew up the...

redpajama_set_name: RedPajamaCommonCrawl


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text:
Shabaash Mithu: Taapsee Pannu Starrer To Go On Floors Next Year; Here's Mithali Raj's Expectations!
Taapsee Pannu earlier took to Instagram to wish Mithali Raj on her birthday, along with which she made the formal announcement of the film.
Taapsee Pannu is gearing up to play former captain of the Indian women's cricket team, Mithali Raj, in the biopic "Shabaash Mithu". The actress informs shooting for the film will start in the middle of 2020.
"It is going to be difficult, I know. I watch cricket a lot but I never played the game. So, it is going to be challenging for me. Mithali (Raj) has already told me that 'I'd like to see how you play the cover drive!' So, I dream of cover drives now," Taapsee laughed.
"I will start preparing for the film at the start of next year because we are going to start shooting of the film from middle of 2020," added the actress.
On December 3, Taapsee took to Instagram to wish Mithali Raj on her birthday with a series of pictures and a heartwarming message, along with which she made the formal announcement of the film.
Taapsee Pannu has lately been a part of several successful films such as "Badla", "Mission Mangal" and "Saand Ki Aankh", and she has been vocal in her demand that male and female actors should get equal pay.
Has her recent streak of success ensured a hike in her fee? "Yeah… With every successful film, producers are ready to give more," she replied.
Star Screen Awards 2019: From Shahid Kapoor To Kiara Advani – Best & Worst Dressed Of The Night!
Salman Khan's Radhe VS Akshay Kumar's Laxmmi Bomb VS Vin Diesel's Fast & Furious 9 – The Big Box Office Clash!
There are media reports that Taapsee Pannu might be seen essaying a double role in the upcoming "Sia Jia", produced by filmmaker Sanjay Leela Bhansali.
Talking about the film, Taapsee said: "Let me first sign the film, and I will talk about it then. Otherwise, I feel scared to talk about it."
"Shabaash Mithu" is backed by Viacom18 Studios and directed by 'Raees' helmer Rahul Dholakia.
rahul dholakia
Saand Ki Aankh
Sia Jia
Viacom18 Studios
Alia Bhatt, After Getting Hospitalised, Gets Back To The Sets Of Gangubai Kathiawadi Within A Day
Gangubai Kathiawadi: Alia Bhatt & Sanjay Leela Bhansali's Film Is Aiming Diwali 2021 Release?
Gangubai Kathiawadi: Makers Build An Outdoor Set For Rally Sequences With Alia Bhatt
Kapil Sharma Beats Amitabh Bachchan, Neha Kakkar To Become The 'Most...
WWE: Randy Orton Introduces A Mask Gimmick, Twitterati React
Kylie Jenner Mercilessly Trolled Over The Water Pressure In Her $35...
Tandav: Ali Abbas Zafar Confirms Decision Of 'Implementing The Changes'; Controversial...
WandaVision: Hilarious Memes About Wanda & Mysterious Beekeeper Trend On Twitter...
Ellen DeGeneres On Testing COVID-19 Positive: "Everyone Around Me Ran Away"
Jacqueline Fernandez Enjoys A Bike Ride In The City
Koimoi Audience Poll 2020: From Ajay Devgn, Saif Ali Khan's Tanhaji...
Vikas Khanna Backs Kangana Ranaut In Nepotism Debate: "It's Painful To...


But back to focusing on football!
I love this tidbit from FootballOutsiders on Chad Ochocino kicking not only an extra point in last night's game but also a 61-yard opening kick to start the 2nd half.
Heads up Peyton Manning naysayers - he had a great night last night. 10 of 14 for 167 yards and 2 TDs. In less than a quarter. Pretty awesome.
The Brandon Marshall drama continues. If there's any reason I'm glad to be far from my Broncos these days, avoiding the updates on the Marshall saga on the local news would be it.
For updates on other camp news, take a look at FFToday's Training Camp Hype with a team-by-team update for the week.
Athlon/Grogan Sports has some words of wisdom for those of us participating in PPR leagues in PPR Strategy: Yes, that extra point matters a lot.
Top Fantasy Football suggests some guys you might want to target during the middle of your draft if you'd like to bolster up your RBs - Top Mid-Round Fantasy Running Back Steals.
If you missed last night's Live Q&A with the Bruno Boys, don't worry. You can reread the various Qs and get caught up on the latest advice.
Interesting article from the Fifth Down on Jake Delhomme. I grabbed him as my QB2 in the 14th round, 12th pick recently and felt like I was getting pretty good value there. Agree? Disagree? Speaking of this recent draft, in general, this is not my favorite roster. While I could roll out a bunch of excuses about moving and drafting being a poor combo (I really don't recommend it...), or not liking drafting from the #1 overall spot, I think it was just an overall poor effort on my part. We'll see how it all pans out but I'm less than psyched about my roster.
Have you read the book "The Class of Football" by Adam Schefter? After reading some of the best Hall of Fame speeches ever, I'm even less impressed with the way Brandon Marshall conducts himself.
So his case was thrown out. What does he want, a cookie?
I like this draft of yours better than the others. Your first 8 picks are absolutely solid.
What you need to do in the future for your bottom picks is to find some people with some upside potential, such as, Robert Meachem, Justin Gage, Chris Henry, Davonne Bess, Fred Jackson.
What type of distance are you running? The Usain Bolt reference is more sprinter oriented, but most folks out in the real world tend to stick more with 5k's, etc.
Eat right and stretch your hammys!!
Delhomme in the 14th round? You just found a $20 in the parking lot!
Definitely envious you got to watch the track meet live.
It's wild that Mark won a world championship in the marathon.


text:
Scenes from a weird year
December 29, 2021 December 31, 2021 Sara Stewart	0 Comments	Barb and Star Go To Vista Del Mar, Candyman, Dune, Kurt Vonnegut Unstuck In Time, Nicolas Cage, Petite Maman, Pig, Spencer, The Lost Daughter, West Side Story
Once again it's been a weird year in movies, with the pandemic-delayed backlog of 2019 and 2020 titles continuing to trickle out. On the bright side, viewers who'd likely have chosen to shell out for just a few films on the big screen have been able to see a lot more of them at home, many for free with streaming memberships. And hey, even a $20 VOD charge is less than you're going to drop at a cinema if there's more than one of you. I can't claim to have seen every last contender for greatness (I'm looking at you, the 3-hour Drive My Car), so I'll simply say, here are ten pretty good films, from the chills of Candyman to the tropical paradise of Barb and Star.
Celine Sciamma's new movie is as small-scale as her last, Portrait of a Lady on Fire, was sweeping. In this gently Gothic tale, an eight-year-old girl (Josephine Sanz) goes with her parents to pack up her beloved, recently-deceased grandmother's countryside house. While playing in the woods, she meets a neighbor girl (Gabrielle Sanz) who bears a striking resemblance to her and has her mother's name, Marion. What's going on? The minimalist plot spells out very little, which feels terrifically French. The girls (who are twins) seem largely unfazed by the supernatural happening, as only kids can be. At its spookiest, Petite Maman had me flashing to The Shining, but mostly its flavor runs to the sweetly eerie. Sciamma also gets major points for coming at under 80 minutes. Can we get an Oscar category for most humane running time?
Kurt Vonnegut: Unstuck in Time
Kurt Vonnegut photographed by Jill Krementz, in West Cornwall, Connecticut in 1973. (Photo: Jill Krementz)
Director Robert Weide may not have made the year's most technically proficient doc – that honor goes to Edgar Wright's The Sparks Brothers – but he definitely spent the longest time making it. The 62-year-old Weide, who became a diehard Vonnegut fan in high school, began shooting Vonnegut in 1988 and continued right up until close to the author's death in 2007. Over the years Weide (an executive producer of Curb Your Enthusiasm's first five years) dithered about how to knit it together into something resembling a cohesive narrative.
As the title acknowledges, it's an amusing problem when your subject is the guy whose most famous work begins "Billy Pilgrim has come unstuck in time." Weide delivers an intimate, bittersweet portrait of one of the world's greatest authors, and, as we discover via his daughters, not-so-great fathers and husbands. It's a loving, lovely tribute, though, and an incisive look at the darkness that often fuels the best humor.
Director Nia DaCosta's Candyman reclaims the narrative from Clive Barker's 1992 original, shaping it into a topical nightmare that veers from harrowing to campy. The urban legend's mantra, "Say his name," couldn't feel more directly tied to Black Lives Matter, and a recurring motif of shadow puppets used to depict the horrors of White violence against Black bodies is surprisingly visceral. At the same time, this Candyman winks at some of the stereotypes that dog the horror genre, with one protagonist peering briefly down darkened basement stairs and concluding, "Nope!", and an art critic, who sneers at the gauche-ness of directly depicting violence, messily dispatched by the boogeyman. It feels like a knowing smack at the still-prevalent snobbery that often keeps horror from showing up on these end-of-year lists.
The movies may have died this year, but they went out with a bang. Or, in the case of Denis Villeneuve's Dune, with a gut-rumbling BWWWOMP: Composer Hans Zimmer has never been more in his element. This long-awaited movie was one of the year's best reasons to brave the theater, a gorgeous, violent epic full of gorgeous faces meant for a huge screen. That said, it's not without flaws. Despite Villeneuve's protests, his depiction of Timothee Chalamet's Paul Atreides as the mystically anointed rescuer of a Bedouin-esque population has more than a whiff of Lawrence of Arabia-style White saviorism.
This, apparently, was far from author Frank Herbert's intent. So bring a big grain of salt along with your popcorn. But man, what a feast for the eyes and ears. Villeneuve works in a similar palette to his boring, beautiful Blade Runner 2049, but brings plenty of action, and even a smattering of humor. I can't wait for the sequel, though I'm sad Jason Momoa's jovial, fearsome Duncan Idaho won't be around for it.
I've enjoyed Neal Pollack's arguments against Jane Campion's icy Western: It's a movie only critics will love, it's too goddamn bleak. I get that. And yet The Power of the Dog stayed with me in a way few other films did this year. On its face, it's the story of Phil Burbank (Benedict Cumberbatch), surly repressed cowboy and secret Yale man, who fuels his own misery by being horrible to everyone around him. But Campion is stealthily, expertly building a delicious methodical thriller underneath all the abuse. At the end, you can't help but marvel at the clues she's laid down. Combine that with absolutely riveting performances from Cumberbatch and Kodi Smit-McPhee as Phil's primary object of derision, and I just can't deny how great this thing is, bleakness be damned.
Kristen Stewart's turn as Princess Di in this wholly unconventional, drawn-from-reality horror drama should finally convince any holdout doubters about her acting abilities. Nailing Diana's posh accent in an impressively un-showy way, Stewart embodies a woman who felt as trapped as one of the poor foxes hunted by her imperious royal relatives. Director Pablo Larrain, and a tense, stringy soundtrack from Johnny Greenwood, spin Di's story into an imploding nightmare, with many a whispery sequence you can't quite decipher, but never veering too far into arty preciousness.
For every ten bonkers performances, Nicolas Cage usually gives one great one, and this is it. The plot sounds like a porcine riff on John Wick – Cage as an off-the-grid former star chef whose prize truffle hunter is abducted – but instead, this slow-burn drama served up a melancholy longing that resonated especially well in Our Pandemic Times. His journey through the back rooms–and one fight club–of Portland's restaurant culture is a riveting, occasionally very funny travelogue, with a great Alex Wolff as Cage's reluctant chauffeur Amir. Cage's Robin Feld is mourning his lost wife, as well as what he sees as the loss of a cultural generosity of spirit. You can pin almost any metaphor you like onto this well-directed feature debut from Michael Sarnoski. It's also just a nice shout-out to pigs, who are awesome.
You wouldn't expect Steven Spielberg and Tony Kushner to fumble a West Side Story update, and they one hundred percent did not. This gorgeous, thoughtful musical holds on to all of the good stuff while making subtle changes to the cringier aspects of the original – here, for example, the Puerto Rican characters are played by Latinx actors rather than White people in brownface, while Anybodys, the vaguely tomboyish character of the original stage production and movie, is played by an actual trans actor.
And the gang violence here actually feels harsh and dangerous, even interspersed with Sharks and Jets leaping around in Jerome Robbins-esque choreography. Like Dune, it's another reminder of everything we lose when we skip going to see movies on the big screen. The ensemble numbers, particularly the Ariana DeBose-led "America," are meant to be experienced huge, in eye-popping Technicolor, surrounded by other people, in all their glorious, texting-in-the-dark imperfections.
Like Sarnoski, Maggie Gyllenhaal gives a stunner of a directorial debut, with an adaptation of a pitch-black Elena Ferrante novel about the steep downsides of motherhood. The masterful Olivia Colman stars as Leda (as in "and the swan," to give you an idea of the tone we're working with), a Boston professor vacationing solo in a Greek town. A narrative that begins as a familiar reminder of how annoying vacations can actually be – a too-present AirBnB host (Ed Harris), a large family that crowds into Leda's quiet beach spot – blossoms into a time-jumping meditation on just how unbelievably, existentially draining motherhood can be, and what happens if a mother dares say that out loud – or worse.
Kristen Wiig and Annie Mumolo's pastel comic confection arrived in February, the month when it was most needed, and it's become my cinematic happy place. Every detail of this love letter to cullotted fortysomething ladies is calibrated for maximum silliness; it's so rare for a movie to get that tone right. It's as if Wiig spun every daffy SNL character into her dual portrayals of Star and the film's villainness, while Mumolo, Wiig's co-writer on Bridesmaids, finally gets to shine in a leading role. Jamie Dornan plays the love interest, a painfully earnest spy, as hilariously as his serial killer in The Fall was disturbing. From the stylings of lounge singer Richard Cheese, who sings piano odes to dead high school friends and boobs, to Andy Garcia as Tommy Bahama, this is a little slice of delight in a year that desperately needed it.
The Year the Movies Died
Film Critics are Still Cosplaying the Apocalypse
What Sucked In Movies This Year
Tags: Barb and Star Go To Vista Del Mar, Candyman, Dune, Kurt Vonnegut Unstuck In Time, Nicolas Cage, Petite Maman, Pig, Spencer, The Lost Daughter, West Side Story
← BFG Podcast #035: Censorship and a One-Star Matrix
How Do You Solve a Problem Like Cirilla? →
Sara Stewart
Sara Stewart is a film critic and a culture and entertainment writer whose work is featured in the New York Post, CNN.com, and more. A Rotten Tomatoes certified reviewer for both film and television, Sara's work can be fully appreciated at sarastewart.org. But not on Twitter, because she's been troll-free since 2018.
Best-selling crime novelist and children's advocate died late last year at age 79
January 19, 2022 January 20, 2022 Scott Gold	0
'Macbeth' By the Book


text:
Q: Intersections of families of open sets ordered by well-inside relation in Euclidean space Let $\langle\mathbf{R}^n,\mathscr{O}\rangle$ be the $n$-dimensional Euclidean space. Define $\mathbf{Q}\subseteq\mathcal{P}(\mathscr{O})$ to consist of all sets $\mathsf{Q}$ which simultanously satisfy the following four conditions:

*

*$\mathsf{Q}\neq\emptyset$ and $\mathsf{Q}\neq\{\emptyset\}$

*$\forall_{U\in\mathsf{Q}}\exists_{V\in\mathsf{Q}}\,\mathrm{Cl}\,{V}\subseteq U$

*$\forall_{U,V\in\mathsf{Q}}\,(U\neq V\rightarrow \mathrm{Cl}\,V\subseteq U\vee \mathrm{Cl}\,U\subseteq V)$

*$\forall_{A,B\in\mathscr{O}}\,((\forall_{U\in\mathsf{Q}}\,A\cap U\neq\emptyset\neq B\cap U)\rightarrow\mathrm{Cl}\,A\cap \mathrm{Cl}\,B\neq\emptyset)$

So every element of the family $\mathbf{Q}$ is a set in which well-inside relation ($\mathrm{Cl}\,U\subseteq V$) is connected (in the sense of order)  and which is decreasing with respect to this relation, but also satisfies the requirement according to which all open sets with non-empty intersections with all elements from the set must have a common adherent point.
Is it true that for every $\mathsf{Q}\in\mathbf{Q}$ there is a point $p\in\mathbf{R}^n$ such that $\bigcap\mathsf{Q}=\{p\}$? I will be grateful for your help.

A: Yes. (Assuming $\varnothing$ isn't allowed in your $Q$'s, as Joel pointed out.)
First note that for such $Q$, $\bigcap Q$ cannot contain two points. Indeed, if $a,b \in \bigcap Q$ are distinct, we can pick open neghborhoods $a \in A$, $b \in B$ such that $\operatorname{Cl} A \cap \operatorname{Cl} B = \varnothing$ and these two open sets $A$, $B$ contradict condition 4. So it suffices to rule out the case that $\bigcap Q = \varnothing$.
Suppose, for the sake of contradiction, that $\bigcap Q = \varnothing$. Pick a cofinal sequence $U_0 \supset U_1 \supset \cdots$ of elements of $Q$. Define $V_n = U_n \setminus \operatorname{Cl} U_{n+1}$ and consider $A = \bigcup_{n=0}^\infty V_{4n}$ and $B = \bigcup_{n=0}^\infty V_{4n+2}$. Note that $\operatorname{Cl} A = \bigcup_{n=0}^\infty \operatorname{Cl} V_{4n}$ and $\operatorname{Cl} B = \bigcup_{n=0}^\infty \operatorname{Cl} V_{4n+2}$ because $\bigcap_{n=0}^\infty \operatorname{Cl} U_n = \varnothing$. Thus $\operatorname{Cl} A \cap \operatorname{Cl} B = \varnothing$ and yet $A \cap U \neq \varnothing \neq B \cap U$ for any $U \in Q$, which contradicts condition 4.

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Whistler and Vancouver's bid book for the 2010 Games went to the printer this week.
The 420-page bound book covers 18 themes and answers 199 questions on everything from health care to venue construction.
"Of course there are still press checks to be done and toing and froing going on," said Sam Corea, spokesman for the Vancouver 2010 Bid Corporation.
"But it is an exciting time."
It is four years since Vancouver and Whistler were chosen by the Canadian Olympic Committee to put forward Canada's bid for the 2010 Winter Olympics.
The bid book is a culmination of all those years of work.
Broken into three bound volumes the bid book will dedicate 150 bilingual pages to venue description.
There will also be 30 pages on the Olympic Villages. The plan is to have one in Vancouver and another at the entrance to the Callaghan Valley 12.7 km south of Whistler.
Another 24 pages will be devoted to transportation, the Paralympic Games will get 12 pages, culture will get six and the rest of the volumes will cover other explanations on topics such as health-care and security.
The bid book will be sent to the headquarters of the International Olympic Committee in Lausanne in January. Once the IOC is satisfied with it, it will be released to the public.
That is one milestone Vancouver's new mayor, Larry Campbell, is waiting for before going ahead with some type of plebiscite to gauge public opinion.
Campbell has said he is not against the Games but is looking for more information before taking a position.
The Bid Corp plans to meet with Campbell in the near future.
This week also saw the launch of a Supreme Court action which claims a $1.8 million donation by ICBC to Vancouver's 2010 Olympic bid is illegal.
The suit filed by two plaintiffs, Chris Shaw of the No Games 2010 Coalition and Chuck Gould of Surrey, is calling for the money to be repaid by court order.
"We were served yesterday," said Corea referring to the court documents.
"It is before the courts so we can't comment on any of the claims made, whether they are valid or not.
"The legal proceeding will now take its course."
The ICBC contribution is part of the $9.1 million provincial contribution of direct government funding and crown agency funding. The contribution was made in 2000 and was a combination of cash and in-kind services.
"ICBC has been working with the Bid Corp's transportation work group on the various transportation safety initiatives to ensure the transportation plan for the Games is safe and efficient," said Corea.
On average, ICBC spends $10 million a year on claims from crashes on the Sea to Sky highway. An average of five people die and 150 are injured in the 500 crashes that happen on the highway each year.
ICBC believes the upgrades to the highway will make it safer, thereby reducing claims and resulting in the insurance corporation recouping their investment to the bid.
Corea said the lawsuit and the plebiscite have caught the attention of overseas media and others.
"You are in an international competition and so any time something puts you into the news that may not be about your particular legacies and benefits of your bid it can certainly be used by a competitive bid city to create questions about your bid," said Corea.
But when it comes to the IOC they rely on their own information to make conclusions.
"The IOC is going to do a poll and that is the information they will rely on," said Corea.
"There can certainly be another expression of opinion through a plebiscite but will that be an accurate reflection?"
For now, said Corea, the Bid Corp will continue to do what it has always done – tell people about the bid.
• On Wednesday, Dec.11 at 7 p.m. at the Delta Whistler Village Suites David Chernushenko will discuss sustainability and the 2010 Games. The author of three books on sustainable management and the president of Green and Gold Inc, Chernushenko is also founder of Clean Air Champions a non-profit group that involves athletes raising public awareness about air pollution and climate change.


text:
<!DOCTYPE HTML PUBLIC "-//W3C//DTD HTML 4.01 Transitional//EN" "http://www.w3.org/TR/html4/loose.dtd">

<title>HttpErrorInfo</title>
<meta name="date" content="2015-04-22">
<link rel="stylesheet" type="text/css" href="../../../stylesheet.css" title="Style">

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com.breeze.webserver

Class HttpErrorInfo

java.lang.Object

com.breeze.webserver.HttpErrorInfo

public class HttpErrorInfo
extends java.lang.Object

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message

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int
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HttpErrorInfo(int statusCode,
             java.lang.String message,
             java.lang.String stack)

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clone, equals, finalize, getClass, hashCode, notify, notifyAll, toString, wait, wait, wait

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text:
Q: How to load initial state data from sqlite database when Flutter app open I'm making a simple Notepad app using flutter. I want to load already saved data from the SQLite database and initialize the state when the app opens. I tried with the initState() method with the async method. But async methods are not working in the initState() method. Some places say to use Future builder and BLoCs. But I'm not quite sure which is good. What is the best way to implement this in flutter??

A: You've two options.
Option 1 : Do what @UtakarshSharma says. Sample implementation below.
@override
  void initState() {
    super.initState();
    _requestSqlData();
  }

void _requestSqlData(){
   _requestSqlDataAsync();
}

void _requestSqlData() async {
    var _data = await getData();    // call API/await function to get the data
}

Option 2 : Use a call back method after the full-screen load. And use setState to update the screen. You'll have to use flutter_after_layout (https://github.com/slightfoot/flutter_after_layout) It executes the function after layout is completed.  :
void initState() {
    super.initState();
    WidgetsBinding.instance
        .addPostFrameCallback((_) => myAwesomeFunction(context));
}

A: If you know how to load data from sql lite then define that function outside of initstate() using async and await and call it in initstate() .
Initstate can't be async because it must need to run before your main app so we can use an outside function for same.

*

*Define function named sqlData() Using async await

*Call it inside initstate.

A: I found this approach to work for me. use .then() on your async function
@override
  void initState() {
    super.initState();
    db.getData().then((value){
      _valueState = value;
    });
  }

A: Futures are the best way to handle data fetching and displaying them in your custom widget.
    late Future<YourDataType> dataItems;
    @override
    void initState(){
      super.initState();
      dataItems = getData();
    }

You can also add try-catch inside this method
    Future<YourDataType> getData() async{
      return await yourEndPointToFetchData();
    }

Inside the builder use FutureBuilder like this
    FutureBuilder<YourDataType>(
    future: dataItems,
    builder: (context, snapshot) {
      switch (snapshot.connectionState){
        case ConnectionState.none:
          return const Center(child: Text("your message"));
        case ConnectionState.active:
        case ConnectionState.waiting:
          return  const Center(child: CircularProgressIndicator());
        case ConnectionState.done:
          if(snapshot.data == null || snapshot.data.items.isEmpty){
            return const Center(child: Text("no data"),);
          }
          return yourWidget(snapshot.data.items);
        default:
          return const Text("Your message");
      }
  },)


Today's students want an upscale residential lifestyle experience while preparing for life's next chapter.
Student housing has dramatically evolved from what it was in the past, and more so in just the past 20 years. Today's campuses offer thoughtful living spaces with the student experience in mind, including tired dorms renovated to make them comforting, warm and communal, and privately developed, near-luxury residences that expand capacity and help with recruiting efforts. Our portfolio of experience in this space crosses a broad spectrum that includes major remodels of campus landmarks, building a "college within a college" at Arizona State University, as well as a major portfolio of student housing at campuses in Arizona, California and New Mexico, under the leadership of Kitchell company hardison/downey construction, inc.
This "campus within a campus" consists of six residential towers, plus a multi-use building that includes residential, classrooms, offices and space for a student dining facility.
Led by hardison/downey, this total remodel of an ASU icon features two student dining facilities, fitness center, mail and computer rooms, student lounges and a business center. Exterior improvements include new landscaping, courtyards, basketball and sand courts.
A new $165 million, design build project which includes seven 4 & 5-story buildings consisting of approximately 1,444 student beds, 29 resident advisor spaces and two apartments for the professional staff, totaling 383,000 SF; a campus welcome center and a 483-space parking structure totaling approximately 154,000 SF; site utilities, hardscape, site lighting and signage. The project is designed to achieve the CSU's standard equivalent to LEED Gold.
One of our most gratifying projects was the Barrett Honors College at Arizona State University, the first purposely designed four-year live-in college in the state, modeled after similar facilities at Ivy League schools. The goal in designing and constructing this sustainable-living community was to achieve LEED® Silver certification by the U.S. Green Building Council (USGBC). The project exceeded the Silver requirements and was awarded Gold instead — an honor befitting a project for one of the country's top honors colleges. In keeping with its sustainable-living mission, Barrett Honors College has instituted a forward-thinking recycling program that has also exceeded expectations, achieving a recycling rate of 92.6 percent.
Russ' achievements in the student housing realm include the iconic Manzanita Hall at Arizona State University. He brings his expertise to many other marketplaces, as well.


I am creating a project with 6 WBS elements. When I am creating internal activity then my control key is PS01.
My requiremenet is that only for 1st WBS of every project, my internal activity should be ZPS1 and for remaining it would be PS01. Is it possible through substitution ?
Identify a unique number for this one activity (this may have to be part of process) and then use this activity number as reference for the substitution.
That is not only for a particular project. Its for all the projects that 1st WBS should have internal activity with control key as ZPS1 and for remaining it should be PS01.
Here define the 6 levels of WBS as per your requirement.
And in substitution, try to add control Key as fixed value for WBS level 1.


text:
Our Advisory Committee
Caribbean Britain Business Council
Central America Business Council
Cuba Initiative
The Annual Reception 2020
The tourism sector should embrace the Caribbean's history
Caribbean Insight
Cuba Briefing
Central America Briefing
Business of Tourism
Reports & Media
When I visit a country I always try to find an art gallery, museum, or historic building that in some way represents a nation's culture or its past.
In this way not only is it possible to understand more about where I am and the origins and influences that have made a nation's people, but to experience something new in ways that can sometimes be surprising, even moving.
In London, New York, Brussels, Paris and in many other global cities, such offerings are of course extensive and enough to occupy many days of a visitor's time.
In the Caribbean, this is not necessarily so, although some nations have fine galleries, museums and buildings open to the public.
Cuba and Jamaica are particularly well-endowed. In Havana the number of such facilities and sites is extraordinary and includes for example, the National Museum of Fine Arts and the unique Museum of the Revolution. Kingston too has at least ten offerings including the National Museum, the outstanding National Gallery and of course the Bob Marley Museum. In both nations there are also many historic buildings and sites located away from the capital.
More generally however, museums, galleries and historic sites around the Caribbean vary enormously in number, size, scope, quality and intent.
This is because the principal problem they face lies in obtaining and maintaining core funding for the upkeep of buildings, existing collections, and staffing. Moreover, special exhibitions are few and far between, and confusingly some sites, particularly those in smaller islands that have been curated from private collections, seem not to want to explain the context of what is being exhibited, or to encourage new thinking about the past.
Museums and national art galleries first and foremost play an essential role in helping educate a nation's children and citizens about their history and culture. However, few involved in such activities in the Caribbean have sought to enhance their funding by establishing linkages to the tourism industry and those involved in selling a destination internationally in ways that might support a country's visitor offering.
Last November France's President, Emmanuel Macron, pledged in an African context that the continent's heritage "cannot be a prisoner of European museums" and that France would develop and support plans for the repatriation of African artefacts held in France.
Although legally complicated and controversial it is an initiative that could lead to visitors travelling to new French supported museums and galleries in the countries from which the objects concerned were originally taken. If developed in an Anglophone Caribbean framework with Britain – perhaps in relation to claims for reparational justice – a similar idea could lead to the creation of well-funded high-quality museums in the region able to house artefacts relevant to local history in locations that would attract residents and visitors alike.
There is potentially a role for the tourism sector and friends of the region to begin to explore such ideas with, for example, the University of the West Indies based Caribbean Heritage Network and other regional groupings that bring together those who run museums, galleries and historic buildings.
It is now widely accepted that visitors increasingly want authentic cultural experiences, wish to understand more about the country they are visiting, and are interested in spending some of their vacation time away from the beach. It is also accepted that 'responsible tourism' should create more meaningful connections with local people, and a greater understanding of local cultural, social and environmental issues.
There is much more to be written on the subject, but there is in the region and internationally a confluence of interest in heritage issues that could be turned to the region, governments and the industry's advantage.
David Jessop is a consultant to the Caribbean Council and can be contacted at
david.jessop@caribbean-council.org
Previous columns can be found at www.caribbean-council.org
The views and opinions expressed in the Business of Tourism are those of the author and do not necessarily reflect those of The Caribbean Council.
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The President has made clear his desire to develop regional relations in support of his economic goals. He met in J https://t.co/HMVtOdY1Zm
In a political programme published after his election, the President said that he will boost investment and production in Guatemala.
In our latest @CentralAmericaBrief: 'Giammattei replaces Morales as President of @Guatemala' https://t.co/phK43OCoWs
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text:
ARMED FORCES AND SOCIAL CHANGE: NEW BOOK EXAMINES THE STRUGGLE FOR RACIAL & GENDER EQUALITY
Troy Mosley is a retired Army Lieutenant Colonel and is the founder and CEO of Citizens Against Intolerance. Troy is a 20-year veteran with a B.S. in Psychology, earning his commission through Florida A&M University's ROTC Program. Troy has held various military assignments in his 20-year career. He was the lead project officer for the first-ever Fisher House dedicated outside the continental United States, and he served as the Executive Officer for the 212th Mobile Army Surgical Hospital during Operation Iraqi Freedom in 2003. Troy also served as the Administrative Director, Department of Surgery, Walter Reed Army Community Hospital before being selected to be the Army Surgeon General's Executive Assistant. Troy served as COO for Weed Army community Hospital (WACH) in 2009 where he led the Hospital to the best Joint Commission (TJC) Accreditation score in the Army that year. His efforts were instrumental in securing funds for a $300 million new hospital construction project at Fort Irwin, CA, the DoD's first solar-powered hospital. His book The Armed Forces and American Social Change: An Unwritten Truce is available at Amazon and Barnes & Noble.
A Refugee's Story of Survival and Success
Jerad W. Alexander
Veteran's Day i-view — A Vets Story – Growing Up on Military Bases, Serving in the Marines – reflecting on Military Service
For Jerad W. Alexander, military life was ingrained in the very psyche of his family. He grew up on military bases, from the east coast of the United States to Japan and was raised on masculine fantasies of heroism and patriotism. As soon as he was old enough, he enlisted in the Marines – from 1998 to 2006, he served as a U.S. Marine, deploying to the Mediterranean, East Africa, and Iraq. Once there, though, he learned that much of what he had spent his childhood dreaming about was a mirage.
Alexander's searing memoir, VOLUNTEERS: Growing Up in the Forever War (Algonquin Books: Nov 9, 2021), is a trenchant account of his childhood dreams and subsequent military service, which dissects the mythology of war and American patriotism. Alexander earned his MFA in Literary Reportage from New York University Arthur L. Carter School of Journalism and in his new book — courageously holds a multi-faceted mirror up to the face of war, recounting what he witnessed on an unwinnable warfront as he weighs the moral complexity that motivated him and others to serve.
Jerad Alexander is available for interviews starting Monday, November 8, 2021. I would love to get you a copy of the book and to schedule an interview with Alexander. If there is interest, please respond with a preferred date & time and an address to mail the book.
What sets VOLUNTEERS apart from many war memoirs is Alexander's discussion of the motivations that drive young men and women to enlist in the military. While much attention has been paid to military dramas about the upper ranks of highly specialized fields, Alexander witnessed a hole in the story of the average American soldier.
In interviews Alexander can address:
Much of this book describes the author's experiences as a child growing up on military bases. What are some of the things that he loved about this experience?
How was Jerad Alexander's desire to join the military influenced by representations of war in American culture?
When the author's stepdad leaves the base to serve in the Persian Gulf War, young Jerad recounts watching the war unfold on television. Reflect on his observations and reenactments of these images. What effect do you think televised representation of war has on children?
How does the United States demonstrate how much it values the efforts of the members currently serving in the armed forces?
VOLUNTEERS is not only an insider's account of war. It takes you inside the increasingly closed culture that creates our warriors.
Meet Pitman Kennedy
Pitman Kennedy is a retired Master Sergeant with the Air Force where he served for 21 years. He is also
a basketball player development coach, strength and conditioning trainer, and a motivational speaker.
His Air Force experience as a leadership facilitator, time spent with Legendary NNBA Coach John
Lucas, as well as professional and personal development as a player development coach propelled him
to build Sweat Equity Athletic and Leadership Basketball Skill Development LLC in 2014. Mr.
Kennedy is versed in many areas and holds a MS in Management, from National Louis University, and
is currently working on his Doctor of Education at Grand Canyon University. He also holds Masters
Certificates in both Project Management and Lean Six Sigma Black Belt from Villanova University.
Pitman is a certified USA Basketball Youth Development Coach, a Professional Member of the National
Speakers Association and Project Management Institute.
For more information – www.amazon.com/Audacity-Resilience-Refugee-Memoir
Jerad W. Alexander has written for Esquire, Rolling Stone, The Nation, Narratively, and elsewhere. He holds an MFA in Literary Reportage from the New York University Arthur L. Carter School of Journalism. From 1998 to 2006, he served as a U.S. Marine, deploying to the Mediterranean, East Africa, and Iraq. He grew up on military bases, from the east coast of the United States to Japan. He currently lives in New York City, but calls Atlanta home.


text:
Kandal Province Police Finds the Bodies of the Two Boat-Accident Victims
Police personnel examines the body of one of the young women who drown on Jan. 26 in the Mekong River. Photo:police.gov.kh
Phoung Vantha
PHNOM PENH--The police in Kandal Province Tuesday found the bodies of two young women who went missing when the small boat in which they were travelling capsized Sunday in the Mekong River, the General Commissariat of the National Police reported Wednesday on its Web page.
Police officers who were searching for the bodies of the two victims found them floating in the river about 250 meters from the site of the accident.
The victims have been identified as Yoeun Sreypich and Ton Dyna, both 18 years old, who lived in Russey Keo District in Phnom Penh, the General Commissariat said.
The accident took place on Jan. 26 at 4:30 pm when a boat heading for Sneha Island capsized about 10 meters from the shore. It is believed that the boat was overloaded as it was carrying 12 people.
The passengers were rescued except for the two victims who did not resurface after the accident.
The bodies of the young women have been handed over to their families so they can hold funeral ceremonies.
Harris, making history as VP pick, condemns Trump's leadersh...
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Traveling to Mexico? Be Wary of Bandits!
Channel 7 News EL PASO -- A Mexican thief shot and killed an 11-year-old boy as he robbed his family, according to the Mexican newspaper Siglo de Durango.
Rico Banuelas was vacationing with his mother Patricia and his two older siblings when gunmen stopped them on a highway just outside Mazatlan, said Sinaloa police.
As the men took property and money from victims in another vehicle , the driver of the vehicle Banuelas was in attempted to flee the scene. The gunmen opened fire and Banuelas was struck in the head, police added. He died instantly.
Sinaloa state police told ABC-7 they have arrested three men for the murder of the young boy. El Siglo de Dunrango identified the men as Genaro Gallegos Espinoza, Irwin Guerrero Padilla and Rubén Padilla Molina.
The newspaper is reporting investigators found an AK-47 rifle, a handgun, several pounds of pot and stolen items at the residence where the men were arrested.
http://www.elpasotimes.com/news/ci_10062504 Rico was killed Monday while on a family trip to Mazatlan with his family, when armed robbers tried to stop the Volkswagen Jetta in which he was riding at a roadblock.
The family tried to speed past the roadblock, but bandits opened fire on the Volkswagen, fatally wounding Rico and injuring his mother and the driver. Survivors "think there were people up in the trees (shooting) because there were bullet holes in the roof," said Rico's brother, 20-year-old Eddie Bañuelas, who was not traveling with his brother. "All the windows got broken except one that was rolled down. The driver was shot in the leg, thigh and the back shoulder. They had to drive for 20 minutes. They went to the next little town in Sinaloa, where a family helped them out."
I am sure 90% of the Americans (and Canadians) visiting Mexico will not have any problems, just wanted to give a heads up to what can happen and would suggest having a plan on what to do if something should happen. Wary and being in a panic are two different things. Wary means you know things can go wrong and have a plan as to what to do, not to be taken completley by surprise, and doing something to get oneself into more trouble, such as trying to drive past a road block manned by bandits. It seemed to me peole shoud know what can happen when traveling in Mexico to be prepared for what could happen. Have a plan, to keep from being in a panic at the wrong time.
Yes, I guess it is good advice to have a plan regardless of where you travel. The trick is not to have so high a fear level that you don't enjoy the journey.


text:
Feds Pay $1M to Family of Man Killed by Border Patrol Agents
March 4, 2017 March 4, 2017 BIANCA BRUNO
Customs and Border Protection, immigration, Settlement
SAN DIEGO (CN) – A federal judge tentatively approved a $1 million settlement Thursday to be split between the five children of Anastasio Hernandez Rojas, a Mexican man shot with a Taser and beaten to death in 2010 after he was detained for illegally entering the U.S. through the busiest border crossing in the world.
U.S. District Magistrate Judge Louisa Porter's tentative approval, which she delayed signing in case the settlement money needs to go through probate, marks the end of the seven-year litigation that received national attention and shed light on the lack of oversight of the nation's largest law enforcement agency.
"From a practical and realistic standpoint, it would be difficult to put an exact dollar amount on the individual economic and non-economic damages suffered by each of the Plaintiffs," Porter wrote in her 12-page order. "It is fair and reasonable to say that each of the Plaintiffs suffered equally from the loss of their father. Some of the Plaintiffs knew their father well and could well identify their loss of comfort and society from their experience with him. Some of the Plaintiffs … were too young to know their father and suffered from the loss of never knowing him other than from photographs and stories."
The settlement required a judge's approval because some of Hernandez's children receiving the funds are still minors.
Border patrol agents stopped Hernandez in May 2010 for crossing the border in Otay Mesa, and a few days later he was transferred to the San Ysidro Port of Entry to be deported.
On May 28, 2010 he was handcuffed and held face down while agents beat him with batons and repeatedly discharged a Taser at him after he allegedly fought their attempts to restrain him when he did not listen to their orders. Agents eventually realized Hernandez had stopped breathing and took him to the hospital, where he was on a ventilator for two days. On May 31, the hospital took him off life support. The medical examiner ruled that Hernandez's death was a homicide.
Two witnesses had captured the beating on cell phone cameras, and it soon went viral.
Hernandez was an undocumented, long-time San Diego resident, and his death attracted international attention. Sixteen members of Congress sent letters to the Department of Homeland Security, the Inspector General and the Department of Justice demanding an investigation. Calls from Hernandez's family and other immigration activists pressured Customs and Border Protection to make its use-of-force manual public, and studies were launched to examine use-of-force by Border Patrol agents.
The U.S. Department of Justice declined in 2015 to file criminal charges against the agents involved in Hernandez's death, claiming insufficient evidence to pursue a criminal case.
"The settlement isn't justice, but it is a badge of shame," Maria Puga, Hernandez's widow, said in a statement.
"No amount of money can bring back Anastasio. No family should ever have to go through this. We don't want to have more cases like that of Anastasio," she continued.
The family, joined by international law experts, filed a petition in 2016 with the Inter-American Commission on Human Rights in Washington, D.C. The petition claims the U.S. government failed to timely and properly prosecute the Border Patrol agents involved in Hernandez's death.
The Hernandez family was represented by Gene Iredale out of San Diego, who said in a statement that the case "highlights the microcosm of all the problems that plague the CBP."
A spokesman for San Diego's Border Patrol did not immediately return an email request for comment.
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text:
Molecular, Cell and Cancer Biology
All About Worcester
MCCB Faculty
FACULTY POSITION AVAILABLE
The life (and death) of cells
Modeling cancer
Editing the genome
Finding new treatments for cancer
What controls gene expression?
How do tumors grow and spread?
A typical animal genome encodes approximately 20,000 genes. However, not all genes are expressed in all cell types and gene expression often changes drastically over time, such as during embryonic development. Adding further complexity is that the control of gene expression can occur at multiple steps: accessibility of a gene to activating transcription factors, transcription initiation, transcript elongation, splicing of the pre-mRNA, as well as post-transcriptional regulation. At the same time, alternative promoter usage and splicing can greatly increase the diversity of transcripts subjected to regulation. Not surprisingly, disruption at any of these steps can contribute to or cause human disease. MCCB researchers focus on multiple aspects of gene expression in their studies. This work includes a focus on gene expression in the context of normal settings, such as how embryonic stem cells maintain their ability to renew and retain their pluripotency, as well as transcriptional pathways that are known to be blocked in the context of cancer. Research includes particular emphasis on "epigenetic" modes of regulation, such as how accessibility to transcription factor binding sites is controlled and how non-coding RNAs contribute to this process. Several labs also investigate the important role of small non-coding RNAs in post-transcriptional control of gene expression, as well as how splicing is regulated.
Click below to see more details on how MCCB labs are studying the control of gene expression.
Bach Lab
One of the main goals of the research carried out in the Bach lab is to understand mechanisms controlling gene expression during mammalian embryogenesis. The research investigates how the dynamic regulation of transcription factor activity orchestrates cell fate decisions during development and how disturbances can lead to human disease. More recently, the lab also studies how female cells inactivate one of their two X chromosomes in a process called X-chromosome inactivation (XCI), a form of epigenetic gene silencing.
Güngör et al., 2007 Proteasomal selection of multiprotein complexes recruited by LIM-HD transcription factors. Proc Natl Acad Sci USA 104, 15000-5
Shin et al., 2010. Maternal Rnf12/RLIM is required for imprinted X-chromosome inactivation in mice. Nature 467, 977-81
Shin et al., 2014. RLIM is dispensable for X-chromosome inactivation in the mouse embryonic epiblast. Nature 511, 86-9
Baehrecke Lab
Our laboratory studies how steroid hormones control distinct types of cell responses within animal cells and tissues. Researchers in the laboratory combine genetics, genome profiling technologies and proteomics to screen for genes and pathways that control cell survival and cell death. These data are used to develop a comprehensive understanding of the genetic regulatory network that controls cell survival and cell death.
Lee CY, Clough EA, Yellon P, Teslovich TM, Stephan DA, Baehrecke EH. Genome-wide analyses of steroid- and radiation-triggered programmed cell death in Drosophila. Curr Biol. 2003 Feb 18;13(4):350-7. PubMed PMID: 12593803.
Nelson C, Ambros V, Baehrecke EH. miR-14 regulates autophagy during developmental cell death by targeting ip3-kinase 2. Mol Cell. 2014 Nov 6;56(3):376-88. PubMed PMID: 25306920; PubMed Central PMCID: PMC4252298.
Lin L, Rodrigues FSLM, Kary C, Contet A, Logan M, Baxter R, Wood W and Baehrecke EH (2017) Complement-related regulates autophagy in neighboring cells. Cell 2017 Jun 29;170(1):158-171. PMID: 2866617 PubMed Central PMCID: PMC5533186.
Velentzas PD, Zhang L, Das G, Chang TK, Nelson C, Kobertz WR, Baehrecke EH. The proton-coupled monocarboxylate transporter Hermes is necessary for autophagy during cell death. Dev Cell. 2018 Oct 9: 47:281-293. PMID: 30318245 PubMed Central PMCID: in progress.
Benanti Lab
Cell proliferation is controlled by a tightly-regulated transcriptional program, which ensures that cells only proceed through the cell division cycle when they receive the appropriate signals. This program is established by a network of conserved transcription factors, many of which are mutated or misregulated in cancer cells. The Benanti Lab uses yeast as a model system to study the connections between cell cycle-regulatory transcription factors, and to determine how phosphorylation and ubiquitination coordinate their activities. These studies are complemented by work in human cells aimed at understanding the regulation of oncogenic transcription factors that are core components of the cell cycle network.
Landry et al. (2014) Regulation of a transcription factor network by Cdk1 coordinates late cell cycle gene expression. EMBO J; 33:1044-1060.
Arsenault et al. (2015) Hcm1 integrates signals from Cdk1 and Calcineurin to control cell proliferation. Mol Biol Cell, 10.1091/mbc.E15-07-0469.
Fazzio Lab
The actions of most factors that regulate gene expression, including transcription factors, long non-coding RNAs, and others, are modulated by the underlying packaging of each eukaryotic gene into chromatin. The relative "openness" of chromatin controls the access of each of these factors to DNA. Consequently, careful control of chromatin structure is necessary to establish and maintain cell type-specific gene expression patterns. The Fazzio lab studies how chromatin structure is controlled in stem cells, adult cells, and how chromatin structure is perturbed in cancer cells.
Yildirim et al. (2011) Mbd3/NURD complex regulates expression of 5-hydroxymethylcytosine marked genes in embryonic stem cells. Cell, 147(7):1498-510.
Chen et al. (2013) Hdac6 regulates Tip60-p400 function in stem cells. Elife. 2013 Dec 3;2:e01557
Hainer et al. (2015) Suppression of pervasive noncoding transcription in embryonic stem cells by esBAF. Genes Dev. 29(4):362-78.
The Green lab has a broad interest in the mechanisms that regulate gene expression in eukaryotes, and the role of gene expression in various human disease states. They pursue this interest through the use of molecular biology, molecular genetic, and biochemical approaches involving diverse experimental systems that bear on different aspects of gene regulation. Much of eukaryotic gene expression is regulated at the transcriptional level, and the lab has made seminal contributions in transcription factor discovery, understanding the role of basic transcription factors in gene regulation, and elucidating transcription activation mechanisms. Recently, the lab has studied transcriptional regulation in cancer development and has made significant contributions to our understanding of oncogene-directed epigenetic silencing.
Gazin et al. (2007) An elaborate pathway required for Ras-mediated epigenetic silencing. Nature, 449(7165):1073-7.
Hart et al. (2007) Initiation of zebrafish haematopoiesis by the TATA-box-binding protein-related factor Trf3. Nature, 450(7172):1082-5.
Maston et al. (2012) Non-canonical TAF complexes regulate active promoters in human embryonic stem cells. Elife. 1:e00068.
Haynes Lab
Mitochondrial and metabolic perturbations result in numerous alterations in gene expression. The Haynes Lab focuses on the mitochondrial UPR, an intra-cellular stress response that modulates gene expression to repair and recover mitochondrial activity. We have uncovered a novel form of transcriptional regulation based on organelle partitioning of a single transcription factor (ATFS-1 in worms, ATF5 in mammals) that allows cells to evaluate mitochondrial function or dysfunction and adjust transcription accordingly. Researchers in the laboratory examine how ATFS-1 is further regulated and integrates with other metabolic stress response pathways to promote survival during mitochondrial dysfunction.
Nargund AN*, Pellegrino MW*, Fiorese CJ, Baker BM, Haynes CM. (2012) Mitochondrial import of ATFS-1 regulates mitochondrial UPR activation. Science. Aug 3;337(6094): 587-90.
Nargund AN, Fiorese CJ, Pellegrino MW, Deng P, Haynes CM. (2015) Mitochondrial and nuclear accumulation of the transcription factor ATFS-1 promotes OXPHOS recovery during the UPRmt. Molecular Cell. April 2;58(1):123-33.
Haynes CM, Fiorese CJ, Lin YF.(2013) Evaluating and responding to mitochondrial dysfunction: the mitochondrial unfolded protein response and beyond. Trends in Cell Biology. July;23(7): 311-318.
Kaufman Lab
The Kaufman Lab has a long-term interest in proteins that deliver histones to DNA with an emphasis on the DNA-replication linked histone deposition factor termed Chromatin Assembly Factor-1 (CAF-1). In their most recent studies, the Kaufman Lab has discovered multiple nucleolar proteins associated with the CAF-1 p150 subunit. Notably, p150 depletion causes redistribution of multiple nucleolar proteins and reduces nucleolar association with repetitive element-containing loci. Furthermore, the nucleolar functions of p150 are separable from its interactions with the other subunits of the CAF-1 complex. Together, these data define novel functions for a separable domain of the p150 protein, regulating protein and DNA interactions at the nucleolus.
Smith et al. (2014) A separable domain of the p150 subunit of human chromatin assembly factor-1 promotes protein and chromosome associations with nucleoli. Mol Biol Cell, 25(18):2866-81
Matheson TD, Kaufman PD. (2015) Grabbing the genome by the NADs. Chromosoma
Mao Lab
The Mao laboratory studies transcriptional regulation mediated by several signaling pathways (Hedgehog, Wnt and Hippo) in tissue stem cells, progenitors, and transformed cancer cells. They use RNAseq, ChIPseq and Bioinformatics to investigate how tissue- or cancer-specific transcriptional output of these pathways is achieved.
Rajurkar et al. (2012) The activity of Gli transcription factors is essential for Kras-induced pancreatic tumorigenesis. PNAS. 109(17): E1038-47.
Wang et al. (2013) TRIB2 acts downstream of Wnt/TCF in liver cancer cells to regulate YAP and C/EBP function. Molecular Cell 51(2):211-25.
Socolovsky Lab
The Socolovsky lab has identified an epigenetic switch that controls the transition from self-renewal to differentiation in erythroid progenitors. Interestingly, this cell fate decision is orchestrated by the cell cycle and is associated with an unusual process in which there is global loss of genomicDNA methylation, the first such instance to be identified in somatic cells.
Pop et al (2010) A key commitment step in erythropoiesis is synchronized with the cell cycle clock through mutual inhibition between PU.1 and S-phase progression. PLoS Biol. 2010 Sep 21;8(9)
Shearstone JR, Pop R, Bock C, Boyle P, Meissner A, Socolovsky M. Global DNA demethylation during mouse erythropoiesis in vivo. Science. 2011 Nov 11;334(6057):799-802.
Wolfe Lab
The Wolfe Lab focuses on multiple aspects of gene expression, including transcriptional and post-transcriptional control. They are also interested in developing new tools for targeted gene regulation. In addition, the Wolfe Lab is part of the Innate Immune Gene Regulatory Project, a collaborative effort to understand the regulatory pathways that underpin the response of Dendritic cells to pathogens. Regarding post-transcriptional control of gene expression, they are focused on understanding the role of miR-375 in pancreatic endocrine cell development using zebrafish as a model.
Zhu L et al. (2011) FlyFactorSurvey: a database of Drosophila transcription factor binding specificities determined using the bacterial one-hybrid system. Nucleic Acids Res. 39(Database issue):D111-7.
Enuameh et al (2013) Global analysis of Drosophila Cys2-His2 zinc finger proteins reveals a multitude of novel recognition motifs and binding determinants. Genome Res. 23(6):928-40.
Kearns et al. (2014) Cas9 effector-mediated regulation of transcription and differentiation in human pluripotent stem cells. Development, 141(1):219-23.
Molecular, Cell and Cancer Biology (MCCB) • 364 Plantation Street Worcester, Massachusetts 01605
Questions or Comments? Email: MCCBweb@umassmed.edu Phone: 508-856-8989


A couple weeks ago I published an Insight showing the essentials of HDR setup/workflow with Adobe Premiere Pro and Adobe's initial support of HDR in their popular NLE.
One of the features I showed was the 'HDR' mode of the Lumetri scopes. This feature scales the signal to show bright portions of a shot (100nits +) that might be useful to adjust while grading HDR material. While in HDR mode you get a rather useful nit scale to show you how signal (code values) map to actual light output of a monitor.
This functionality, besides being amazingly useful, shows one of the main tenants of Dolby Vision and ST-2084 HDR – there is a direct correspondence of code value to light output.
I really like this scope, and as I said in that Insight, I wish more scope manufacturers and software designers would considering adding something like it in the future.
After publishing the Insight, I got several emails from members (remember you can always use the comments!) expressing confusion about how to read scopes (particularly the Luma Waveform & RGB Parade) when setup to grade HDR in other applications like Resolve.
True, but in a tool like Resolve when using RCM to aid you in working with HDR footage, the Waveform & RGB parade can get confusing – particularly when it comes to white level and where clipping may occur.
If I asked you when grading SDR footage where is black and where is white on the Waveform & RGB Parade in Resolve you'd tell me '0 and 1023' (let's avoid all the full range/legal range, internal processing etc. talk for this discussion).
That knowledge is burned into your brain, as is how to detect clipping and other essentials of using these scopes.
When you switch Resolve to RCM (Resolve Color Management) and choose any of the ST.2084 (HLG works in a similar fashion for this discussion), Things get weird!
Compared to the standard REC 709 signal (Left) when enabling RCM and choosing an ST2084 Output Color Space (Right) the waveform scales considerably even with no grade applied.
With a 2084 output color space applied, the signal as seen on the Waveform or RGB Parade scales in a pretty dramatic fashion (see above screen shot).
Remember 2084 is based on the PQ curve that Dolby researched and SMPTE endorsed. Without getting into the detailed math, the PQ curve makes a direct correlation between code value and nits.
This is why, as I'll show you in the video below, that choosing a different NIT output option from the 2084 choices for output color space in Resolve scales the signal accordingly.
One of the most striking ways that this scaling effects monitoring the scopes is with white point clipping.
One of the strangest byproducts of this scaling – your white clip point isn't 1023 anymore! One day it might be (using current scopes) and when there are 10k+ Nit displays. Remember, the specification calls for 10,000 nits for future displays.
When that happens, 1023 in Resolve in a 2084/PQ workflow would map to near 10k Nits (again, yes, I realize things are slightly more complicated with legal/full range mapping and 2084 using legal mapping, but since Resolve is always internally full range and displays that full range on the scopes, it's a moot point).
For now, in Resolve and using RCM, when you choose say 1000 Nits, your white clip point (because of the scaling described above) changes to 768, and not 1023.
While these numbers are approximate, they're easy to see for yourself using the reference level option as I'll show you in the movie.
You may have also noticed the numbers don't seem proportional. That's simply because of the shape of the PQ curve.
In other words, the logarithmic shape of PQ curves uses less code values at the top end of the curve. Only about 7% of the full range is used to define 5,000 – 10,000 nit. Indeed, the PQ curve was designed to 'spend' most of the code values in the middle portion of the curve where the argument is they're more perceptually important.
One of the reasons I like the Adobe approach so much to HDR Waveform monitoring is that it's clear and concise and shows you what you need to see.
With that said, I don't mind how things are in Resolve; I would just like options.
Right now the Resolve team, and in general anyone building scopes for software, probably just aren't that motivated to build HDR specific graticules – there are just not that many people grading in HDR.
But I think over the next year or two we'll see that change and see different ways of viewing the HDR signal when it comes to scopes. That change of course is not limited to just the Waveform and RGB parade as larger gamut's are introduced and more widely used – like REC 2020 color measurement i.e. the vectorscope will probably have to adapt too.
As always questions or additional thoughts please use the comments below.
P.S. After posting this I got several emails about my RED Raw settings and RCM. When switching over to RCM gamma and color space settings become irrelevant BECAUSE of RCM. You can switch these settings to anything you'd like and see no change of the image when in RCM. I only pointed them out to explain what I had done prior to changing the project over to RCM.


This customized bobblehead is uniquely made for the winter lovers. Winter is a fantastic season, and if you choose to have this bobble on your desk, it will make your winter much more fantastic!!
I love winter, especially the white snow. Though the clothes are heavy in winter, but since of the snow, I can bear it. When the white snow comes down from heaven, it covers all the dirtiness of the earth. Though only for a while, but really beautiful and clean. I love winter, and to remind me of the beauty of it, I'd have this custom bobblehead which is tailor-made for myself!


Jerry Vines recounts some of his experience in the Conservative Resurgence with Tennessee writer Ron Hale.
"Around 300 students, faculty, and pastors came to watch the three-hour debate hosted by NOBTS on October 19, 1987."
J.R. Graves: Looking back at Landmarkism?
...Ross developed disturbing doubts concerning certain points of his Calvinistic doctrine.
Five Pre-Reformation Bad Boys – Were They Saints or Sinners?
This article will spotlight five non-conformists who lived as sinners in the eyes of Papal authorities but died as saints in the eyes of their followers.
Church Planting – or – Evangelism in the SBC?
It's the proverbial "chicken-or-the-egg" kind of question.
Do You Know the Koranic Code?
... history soon has two Korans..


'Tis the season for sharing. Germs that is.
Nobody wants a cold or the flu but most of us, especially children can catch up to a dozen colds a year. Luckily as we get older, most adults catch only 2 to 4.
• Place boxes of tissues throughout the house. While not the highest fashion for your décor having a tissue very close at hand can help assure sneezes are caught and tossed, not sprayed.
• Wear mittens or gloves when out. Not just to keep your hands warm but to avoid touching common surfaces such as door knobs. Then toss the mittens in with the weekly wash.
• Wash your hands as soon as you get home from school or work.
• Frequently wipe shared surfaces including door knobs, light switches, stair rails and the microwave door with a disinfectant wipe. Our professional cleaners disinfect these surfaces with our regular cleaning, however an extra wipe or two between cleanings is a great idea during cold and flu season.
• And while you have a wipe handy, give the TV remote and computer mice and track pads a quick wipe too. We hope these tips help keep your family healthier so you can enjoy sharing the good times and holiday cheer.
A large scale research study proved it: you can buy happiness if you spend your money on time saving services!


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Yesterday, Gearbox Software released a new trailer teasing a Borderlands-related announcement. Some presumed it would be Borderlands 3, and so… This evening, at PAX East, Borderlands 3 was confirmed and announced!
Not much has been known about Borderlands 3, but they said to go to Borderlands.com on April 3rd for more information. Also, that wasn't the only Borderlands announcement made at PAX East. The Handsome Collection is getting a new version called "Borderlands: The Handsome Collection Ultra HD." In Ultra HD, there are some new features such as 4K support and a bigger emphasis on co-op play.
Both games are coming to PlayStation 4, Xbox One, and PC. More information about Borderlands 3 is to come on April 3rd!


text:
package io.quarkus.mongodb;

import static java.lang.annotation.RetentionPolicy.RUNTIME;

import java.lang.annotation.Documented;
import java.lang.annotation.ElementType;
import java.lang.annotation.Retention;
import java.lang.annotation.Target;

import javax.inject.Qualifier;

/**
 * Marker annotation to select mongo connection of cluster configuration
 * Use name parameter to select it
 *
 * For example, if a mongo connection is configured like so in {@code application.properties}:
 *
 *

 * quarkus.mongodb.cluster1.connection-string=mongodb://localhost:27018
 *

 *
 * Then to inject the proper {@code MongoClient}, you would need to use {@code MongoClientName} like so:
 *
 *

 *     &#64Inject
 *     &#64MongoClientName("cluster1")
 *     MongoClient client;
 *

 */
@Target({ ElementType.TYPE, ElementType.METHOD, ElementType.FIELD, ElementType.PARAMETER })
@Retention(RUNTIME)
@Documented
@Qualifier
public @interface MongoClientName {
    /**
     * Specify the cluster name of the connection.
     *
     * @return the value
     */
    String value() default "";
}


text:
Debian 10, 11 (32/64Bit)
Debian is one of the oldest operating systems based on the Linux kernel. The project is coordinated over the Internet by a team of volunteers guided by the Debian Project Leader and three foundational documents: the Debian Social Contract, the Debian Constitution, and the Debian Free Software Guidelines. New distributions are updated continually, and the next candidate is released after a time-based freeze.
The Debian Project is an association of individuals with a common cause to create a free operating system. This operating system is called Debian GNU/Linux, or simply Debian for short. Debian systems currently use the Linux kernel and most of the basic OS tools come from the GNU project. Linux is a completely free piece of software started by Linus Torvalds and supported by thousands of programmers worldwide.
Debian comes with thousands of packages (precompiled software that is bundled up in a nice format for easy installation on your machine) - all of it free. It's a bit like a tower. At the base is the kernel. On top of that are all the basic tools. Next is all the software that you run on the computer. At the top of the tower is Debian -- carefully organizing and fitting everything so it all works together.
Debian has access to online repositories that contain over 51,000 packages. Debian officially contains only free software, but non-free software can be downloaded and installed from the Debian repositories. Debian includes popular free programs such as LibreOffice, Firefox web browser, Evolution mail, K3b disc burner, VLC media player, GIMP image editor, and Evince document viewer. Debian is a popular choice for servers, for example as the operating system component of a LAMP stack.
Several flavors of the Linux kernel exist for each port. For example, the i386 port has flavors for IA-32 PCs supporting Physical Address Extension and real-time computing, for older PCs, and for x86-64 PCs. The Linux kernel does not officially contain firmware without sources, although such firmware is available in non-free packages and alternative installation media.
Desktop environments
Debian offers CD and DVD images specifically built for XFCE, GNOME, KDE, MATE, Cinnamon, LXDE, and LXQT. MATE is officially supported, while Cinnamon support was added with Debian 8.0 Jessie. Less common window managers such as Enlightenment, Openbox, Fluxbox, IceWM, Window Maker and others are available.
The default desktop environment of version 7.0 Wheezy was temporarily switched to Xfce, because GNOME 3 did not fit on the first CD of the set. The default for the version 8.0 Jessie was changed again to Xfce in November 2013, and back to GNOME in September 2014.
Several parts of Debian are translated into languages other than American English, including package descriptions, configuration messages, documentation and the website. The level of software localization depends on the language, ranging from the highly supported German and French to the barely translated Creek and Samoan. The Debian 10 installer is available in 76 languages.
Multimedia support has been problematic in Debian regarding codecs threatened by possible patent infringements, without sources or under too restrictive licenses. Even though packages with problems related to their distribution could go into the non-free area, software such as libdvdcss is not hosted at Debian.
Product Code: B08HR13XYD
Debian 10
LXQT


Done Masters in Fisheries Science from Department of Fishery Biology, College of Fisheries, Panangad, Kochi, Kerala. I joined for ARS service in 2011 (94th FOCAR at NAARM). I have been working as Scientist in Crustacean Fisheries Division at Madras Research Centre of CMFRI, Chennai since 2012. I am currently working on stock assessment of Crustacean resources. I am involved with the GIS based resource mapping and remote sensing assisted marine resources forecasting. Also carried out survey on availability of pearl oyster along north Andhra Pradesh coast. I am particularly interested in fish biology and biodiversity.
2009 ICAR SRF for PhD in CIFE.
1. Divipala, Indira and Thirumilu, P (2013) Unusual landing of the rare penaeid shrimp Metapenaeus lysianassa at Karaikkal, south-east coast of india. Marine Fisheries Information Service; Technical and Extension Series (215). pp. 32-33.
2. Divipala, Indira and Thirumilu, P (2013) Rare occurrence of two stomatopod species from Chennai coast. Marine Fisheries Information Service; Technical and Extension Series (215). p. 33.
3. Geetha, R and Divipala, Indira and Vinod, K and Kizhakudan, Shoba Joe and Manivasagam, M and Zacharia, P U (2013) Coastal vulnerability to climate change: A pilot study in Cuddalore district of Tamil Nadu. Marine Fisheries Information Service; Technical and Extension Series (217). pp. 42-45.
4. Divipala, Indira and Anna Mercy, T V and Nair, J Rajasekharan (2013) Reproductive biology of Chela fasciata Silas – an endemic ornamental barb of the of Western Ghats of India. Indian Journal of Fisheries, 60 (4). pp. 41-45.


Railway City Brewing creates a series of locally handcrafted beers in St. Thomas, ON. We proudly feature malted barley (grain), hops, yeast and water as our primary ingredients. Each beer is locally brewed, all natural, and crafted in small batches, using only the finest ingredients with no artificial adjuncts or preservatives.
The history of Railway City. The railway has been a part of St. Thomas since the completion of the London and Port Stanley Railway in 1856. More than 26 railways passed through the city. St. Thomas was the fastest shortcut between Chicago and New York: two major railway cities. This provided the foundation for the birth of St. Thomas due to the provision of employment and, subsequently, the income to sustain the community. St. Thomas then became known as "Railway City".