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Welcome to official website for the North American Swiss Singing Alliance (NASSA) Saengerfest 2018, held in HOLY TOLEDO!
Thank you to all the member choirs of NASSA for coming to Toledo and experiencing what a vibrant and thriving community we have. Thank you, Toledo, for coming out and supporting our group and to all who visited the Renaissance Hotel and experienced a little bit of yodeling. Thank you to our local media, especially WTGE Public Media and Lamar Advertising, for helping us get the word out that, "Yodeling is coming!"
We'll be sharing more on the website in the coming days, but in the meantime, sit back and relax, singers and Toledo Swiss Singers. We've earned a nice summer break.
Don't forget to order your exclusive "Yodel Better in Toledo" apparel, for a limited time! Learn more about Saengerfest apparel.
Check out our local media coverage and promotion.
For information on photos taken during the weekend by our photographer, please connect with Andrea Myers on her Facebook.
Saengerfest 2018 is an international Swiss singing and yodeling festival hosted by The Toledo Swiss Singers in Toledo in June 2018.
The Singers are part of North American Swiss Singing Alliance (NASSA), made up of 14 choirs from Canada and the U.S. Hundreds of singers from around North America will descend upon the Glass City for the long summer weekend.
Saengerfest 2018 marks the culmination of three years of preparations for The Toledo Swiss Singers. Groups compete internationally every three years.
The most recent competition and festival was held in June 2015 in New Glarus, Wis. The Toledo Swiss brought home gold and silver prizes from the Prize Song Competition singing.
And now, Toledo is in the spotlight and we hope you will join us for the weekend, especially at the Grand Concert on June 30!
Video courtesy Swiss Center of North America's YouTube channel.
Saengerfest 2018 - Swiss Singing and Yodel Festival - Toledo, Ohio: What is Saengerfest?


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Detroit Tigers' Tyler Collins taking ill-timed lat injury in stride
Collins, cleared to throw on Thursday, isn't sweating after a lat injury hindered his chances to start in CF
Anthony Fenech
PORT CHARLOTTE, Fla. – Tyler Collins swears he isn't antsy. Not even a little bit.
This, in itself, is an example of how the Detroit Tigers' outfielder has grown in the past year.
If an injury had hit Collins early last spring, during his annual battle for a roster spot in spring training, he likely would have kept quiet and played through it just to stay on the field.
"Definitely," he said.
Now, Collins is keeping things in perspective, even after a left lat injury all but derailed his bid to become the Tigers' starting centerfielder on Opening Day. And so on this morning at Charlotte Sports Park, before the Tigers took on the Rays in a Grapefruit League game, Collins stood in centerfield, shagging fly balls and softly tossing them toward the infield.
He had been cleared to throw on a day earlier, and he wasn't going to take any chances by over-exerting.
"It feels fine," Collins said. "I honestly, I don't even notice it."
Lou Whitaker making presence felt in Tiger Town
Detroit Tigers aide: MLB replay reform is wrong
Collins, a competitor with Mikie Mahtook for the Tigers' vacant centerfield spot, is creeping closer to game action. He began a throwing program on Thursday, including from 90 feet, but he's probably days away from returning to action and resuming the centerfield competition in earnest.
"We've got so many guys out there and it hasn't jelled yet," manager Brad Ausmus said. "Part of the reason it's disjointed at this time is Tyler hasn't been out there yet."
Collins will take Saturday off from throwing. He will increase the distance to 120 feet on Sunday, and then 150 feet. He hopes to return to the outfield sometime during next week.
"I have full confidence in my ability to play the field," Collins said. "It's just about getting at-bats right now."
Collins went 0-for-3 with two strikeouts in the Tigers' 5-2 loss to the Rays on today. But he has looked the part of a more mature player this spring. He's hitting the ball with more authority, and his demeanor appears calmer, despite being on the cusp of earning a starting job entering the spring.
Ausmus has noticed the same but reserves judgment until the regular season.
Advice for getting single-game Detroit Tigers tickets
An although Collins profiles as a likely left-handed platoon candidate to Mikie Mahtook in centerfield, the Tigers want to see him play consistently in centerfield. There still are questions about his range in the outfield, especially at sizeable Comerica Park.
Asked what kind of ground Collins has lost with the injury, Ausmus said: "He's lost a chance to play centerfield, which is one of the very few positions we have an opening at.
"I'm not worried about him being in shape but I still want to see him in centerfield. We have time, though. We're not going to rush him in case of a long-term injury."
Collins, with a demeanor Ausmus compared to a bull in a China shop the past couple years, has come a long way. The waiting, he assured a few reporters, wasn't the hard part. It hardly was on his mind.
After eating healthy this off-season – his girlfriend's organic cooking helped him chisel into the most competitive playing weight of his career – he's stress-free at a time when he normally would be pushing into extra gear to get back on the field.
"The hard part is answering questions about people wanting me to be antsy and me not being antsy," he joked. "It is what it is. There's no point running around, going crazy, pulling something again and trying to get back too soon. It's like, you can just play defense, just get your at-bats, get back out there and get back in the game."
Contact Anthony Fenech: afenech@freepress.com. Follow him on Twitter @anthonyfenech.

redpajama_set_name: RedPajamaCommonCrawl


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Is 66859 the best Kansas zip code for your business?
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All 66859 population data above are from the US Census Bureau.
The population data for 66859 are from the Census' American Community Survey 2017 5-year estimates. The demographic data for 66762, 67361, 67364, 67458, and 67736 are the most current, comparable demographics available from the US Census Bureau, are from the American Community Survey 2017 5-year estimates, and were downloaded on December 2017. Check out our FAQ section for more details.
With 228 people, 66859 is the 549th most populated zip code in the state of Kansas out of 694 zip codes. But watch out, 66859, because 67364 with 227 people, 67458 with 223 people, and 67736 with 223 people are right behind you.
The largest 66859 racial/ethnic groups are White (81.6%) followed by Hispanic (13.2%) and Asian (5.3%).
In 2017, the median household income of 66859 residents was $35,446. 66859 households made slightly more than 66762 households ($35,277) and 67361 households ($35,250) . However, 11.0% of 66859 residents live in poverty.
The median age for 66859 residents is 51.8 years young.
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Casebook -> Home
The Lago de Cote photograph:
The picture on the right shows an unknown object, which was captured on film by an official mapping plane of the Costa Rica government on September 4, 1971, while flying in the region of Arenal over the lake "Lago de Cote." A camera, mounted on the plane, took a picture of the terrain about every seventeen seconds. The entire picture, covering an area of seven by seven miles, shows remarkable detail. It is possible to distinguish roads, animals, and trees. Which is no surprise considering that it was taken with a high quality professional camera. The first detailed analysis of this picture was undertaken by Dr. Richard Haines and Dr. Jacques Vallée, who obtained the original negative for study.
The case:
The absence of any shadows on the surface of the earth tends to suggest that the object itself is at or close to the surface; Hence, no shadow of the disk would be expected. Equally intriguing is the fuzzy area on the left side of the disk, which may be explained by the possibility that the disk was partially submerged, producing the irregular boundary. Aside from visual inspections of the negative and enlarged prints, with different contrasts, computer enhancement was used to uncover further details after which the authors concluded:
"In summary, our analyses have suggested that an unidentified, opaque, aerial object was captured on film at a maximum distance of 10,000 feet. There are no visible means of lift or propulsion and no surface markings other than dark regions that appear to be nonrandom... There is no indication that the image is the product of a double exposure or a deliberate fabrication."
Haines, and Vallée, 1989.
Computer scientist and ufologist Jacques Vallée participated in this photograph's analysis and stated in a recent interview:
"Digital enhancement of photographs is very useful. In my book, Confrontations, I mention the photograph that I brought back from Costa Rica, which was unusual because the object was over a lake [Lago de Cote], so there was a uniform black background. Everything is known about the aircraft that took the photo. At the time the picture was taken, nobody on the plane had seen the object. It was only after the film was developed that the object was discovered. The camera used was exceptional: It produced a very large negative - ten inches, very detailed. You can see cows in the field. The time is known; the latitude, longitude and altitude of the aircraft is known. So we spent a lot of time analyzing that photograph, without being able to find any obvious natural answer to the object. It seems to be a very large, solid thing."
"I obtained the negative from the government of Costa Rica - if you don't have the negative, analysis is a waste of time. I also obtained the negative of the picture taken before and the picture after, all uncut. I took negatives to a friend of mine in France who works for a firm that digitally analyzes satellite photographs. They digitized the entire thing, and then analyzed it to the extent that they could, and could not find an explanation for the object."
This photograph,which has been thoroughly investigated, is on tof the may photographic prrof of the reality of UFOs as solid and material crafts of non terrestrial origin.
Haines, Richard and Vallée, Jacques, "Photo Analysis of an Aerial Disc Over Costa Rica," Journal of Scientific Exploration, Vol. 3, No. 2, 1989, pp. 113-131.
Haines, Richard and Vallée, Jacques, "Photo Analysis of an Aerial Disc Over Costa Rica: New Evidence," Journal of Scientific Exploration, Vol. 4, No. 1, 1990, pp. 71-74.
Vallée, Jacques, "Confrontation", book.
This page was last updated on September 15, 2001.


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Are Tide Pods a Delightful Snack or a Detergent?
Sarah McCarthy
Lately, it seems every two months or so, the social media world embraces a new viral challenge. Some of you may remember the cinnamon challenge from way back when or, more recently, the water bottle flip or the mannequin challenge, but few seem to have infiltrated the college world as deeply as the Tide Pod challenge. Similar to all viral challenges, the Tide Pod challenge seems to be grounded in a group of friends daring one another to eat the detergent pack while recording a video that is subsequently posted to YouTube, Instagram, or other social media outlets. While the Tide Pod challenge has seen less participation than other challenges, such as the mannequin challenge, it has been wholeheartedly embraced by many college students around the nation.
Even though this may seem like an unintended marketing campaign for Tide and its parent company, Procter & Gamble, ingesting the detergent packs can have severe side effects. The chemicals used in Tide Pods are intended to decompose waste materials and include surfactants which attach to water and grease; in the human digestive system, the stripping of these two molecules can be quite harmful to the digestive tract. This can lead to vomiting, diarrhea, and abdominal pain. Additionally, due to the toxicity of the pods, people who eat them may experience numbness in the mouth or, because of the bleach in the Tide Pods, may experience intense vomiting and burning of the digestive tract. The rarest, but most dangerous, consequence of taking part in this challenge comes from breathing the detergent directly into your lungs, causing asphyxiation, which can lead to fainting and, in some cases, seizures.
Initially remaining on the sidelines, Procter & Gamble has recently launched a campaign to discourage users from taking part in the Tide Pod challenge. According to The Guardian the company's spokesperson said, "We are deeply concerned about conversations related to intentional and improper use of liquid laundry packs."
The company urged YouTube to remove all videos posted that feature someone eating a Tide Pod, to which YouTube said they were working urgently to remove videos as they censor all content that encourages harm to self or others. Procter & Gamble also created an ad featuring Patriots star Rob Gronkowski in which he says, "What the heck is goin' on, people? Use Tide Pods for washing; not eating." Tide's Twitter feed has also recently fielded many questions regarding the challenge and what to do after consuming a Tide Pod. All of their answers urged tweeters to call poison control or a doctor and to drink a large glass of either water or milk.
Social media phenomena raise important questions about adolescence and the role of peer pressure. While the influence of others during this period of life has long been understood, the era of social media and the twenty-four-hour news cycle bring these issues to life on a daily basis. What does it say about our culture that people are willing to risk serious illness and possibly death in the hopes of becoming "Instagram famous?"
Not only should we aim to end participation in the Tide Pod challenge, but we should also attempt to understand the motivations for becoming a viral sensation or a meme, and how outlets, such as Barstool, encourage unruly and possibly harmful behavior in the hopes of impressing millions of strangers.
Although risk taking and limited inhibition are defining factors of the adolescent period, the role social media plays in emphasizing and promoting hazardous behaviors is pertinent.
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American stars boycott Instagram for a day: 'Stop hate speech'
2 years ago Michael McCann
Among the co-stars are big names like Leonardo DiCaprio, Jennifer Lawrence, Katy Perry and Kim Kardashian, who run one of the top 10 Instagram accounts with 188 million followers.
Kim wrote on Twitter: "The disinformation circulating on social media has a dangerous effect on our elections and undermines our democracy." It invites its millions of followers to also participate in the working group's "Stop Hate for Profit" initiative.
Tougher action against the preachers of hate
The Stop Hate For Profit has been stressing Facebook for some time. The organization wants social media channels, including Instagram and Facebook, to take responsibility for the content of its users. They should take tougher action against hate propagandists, racism and conspiracy theories. Something that doesn't happen often according to the working group.
Failed boycott
In July, the working group tried to win over Facebook across the county. A thousand advertisers will avoid the site for a month, causing Facebook to lose revenue. But the business was not successful. Not enough advertisers entered, and those who did came back a month later.
Work week
Stop Hate For Profit will take action again this week. The immediate cause is the upcoming presidential elections. In the run-up to the election, more and more incorrect information about the candidates will be circulating on Facebook.
Another cause is the shooting accident in Kenosha, USA. A 17-year-old boy shot two black protesters there. After the shooting, the online shooter was glorified as a hero by the right-wing extremists.
See also Netflix Is In Stiff Competition: HBO Max Moves Globally!
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You are browsing the Blog for Anthropology Archives - Marja-Leena Rathje.
After a morning at Sointula, we took the ferry back to Port McNeill, then drove right back on it for the leg to Alert Bay on Cormorant Island, about 40 minutes away. These ferry trips were a joy on another beautiful sunny day.
Our plan was to visit Alert Bay's noted numerous totem poles and its U'mista Cultural Centre. Our first stop was at the visitor centre to get both print and verbal information and directions which were excellent. But also some bad news… the U'mista Cultural Centre was closed on Mondays! I felt very sorry that I had not rechecked the website concerning the fall and winter schedule change. We were also told that there had recently been a fire in one part of the museum so that part was closed for restoration work.
Still, we saw a lot in our afternoon there and took so many photos that I will have to show them over more than one post. Today's focus is on the the island's largest grouping of totem poles on the Namgis Burial Ground. Being sacred ground, viewers were requested to view these from the road, not a problem though I am grateful my husband captured some closer shots with his newer and more powerful camera.
We were given brochures which are very helpful in learning more about totem poles in general and Alert Bay's in particular. One is available also as a PDF. I recommend the page "what is a totem pole?" Are these not amazing works of art and spirit?!
This sounds most interesting to me. As a member of this organization, I am going to attend and will report back here afterwards. Everyone is welcome of course.
The lecture was excellent, very informative and fascinating. Ms Elg began in Finnish, so wonderful and rare now to my ear – then switched to English, with a Finnish accent. I often have trouble understanding accents, even Finnish ones but still I was able to catch most of the information along with the help of the slides of language charts and maps. A good turnout and lots of questions throughout and everyone most appreciative.
Ms Elg described the Finnish language program at the University of Washington, one of many universities around the world that teach Finnish as I found out earlier.
So, one word replaces many words in the equivalent English and many other languages. Some words can be from 6 to 10 cases. Hungarian can have up to 24 cases!
What I don't understand is how the study of languge can determine its age. For example the oldest Finnish word kala (fish) is 6000 years old. Loan words have been dated to reveal the periods of movement by different groups into Finland. Very personal words like äiti (mother), which came from German less than 1000 years ago (a surprise to us all), reveal close relationships like marriage and children. Yet that word is not currently in the German language.
A brief mention was made of a controversial theory presented by Professor Emeritus Kalevi Wiik of the University of Turku in Finland. He argues that Finno-Ugrian languages may originally have been spoken by the whole of northern Europe, that it may be Europe's oldest language. More about his theories here or his home page in Finnish.
So much more but I'll leave it at that! No definitive answers but interesting food for thought on our language, where we came from and who we mixed with. This has been a wonderful addition to my readings over the years and to the numerous links, many in Finnish, which I've gathered here and there.
On a recent visit to Arkeo Net**, a Finnish portal for archaeological and prehistoric information, I found an interesting, informative and beautifully designed website: Recalling Ancestral Voices, concerning the repatriation of Sámi cultural heritage.
Recalling Ancestral Voices is a project dedicated to recording the material cultural heritage of the Sámi. The project was launched in April 2006 and will end in November 2007. In Finland, the Sámi Museum Siida is participating in the project, in Sweden, the Ájtte Museum in Sweden and Varanger Sámi Museum in Norway. The project is part of Interreg III, which is funded by the European Union.
The site is presented in Sámi, Finnish, Swedish and English, with detailed information about the project, the issue of repatriation common to all indigenous people, the people involved in the project, the artefacts and much more.
Later note: One small criticism though – I wish active links had been posted, such as to the various museums mentioned.
I wrote about this fascinating site back in February. At that time I had copied this poem into my little notebook of quotes and interesting ephemera, and came across it again this morning. I just had to share it with you today, as I keep thinking about my deep fascination for my own origins, of the origins of the Finno-Ugrics, and of all humans. I'm understanding more and more that this is at the very root of my fascination and passion for the traces left behind by these early people on rocks and cave walls, in their sculptures, standing stones, dolmens, pottery, jewelry and so on. And this passion naturally translates into my own art work.
"Origins" means the fons et origo, the fountain, the source, the waters of life, the depths, the springs of the creative process, our religious, spiritual and creative imagination, both collective and individual and in all living beings.
In 2003, an aboriginal woman who is likely a descendant of those early Australians stumbled across dozens of timeworn footprints in the same area. Excavations of the site have since uncovered hundreds more.
The discovery, detailed in a recent issue of the Journal of Human Evolution, represents the largest collection of Pleistocene human footprints in the world, and the only footprints from that era ever found in Australia. In total, 457 footprints have now been uncovered.
Humans weren't the only ones that passed through the area. The prints from two kangaroo hind paws are visible, as are the tracks of a baby emu, a large flightless bird similar to an ostrich.
Read more at LiveScience. Found at Zinken.
I've been happily lost in my travels through the pages of the Atlas of the Human Journey. I'm always fascinated to learn more about the amazing migration of humans from Africa to all the far corners of the earth. Clicking on "Journey Highlights" on the lower right hand corner brings up a long list of different cultures, languages, anthropology and archaeological sites with some history or other interesting bits of information. The mention of some yet unproven theories on how some peoples arrived where they did reveals how much is still unknown. The Saami culture and other more obscure ones are even on the list, something you don't often see in these kind of broad studies.
As most readers know, a great deal of new information has been recently discovered through the modern science of genetics. So, this site happens to be a part of the Genographic Project. Read the fascinating information here about DNA and genetic markers. I'm rather tempted to order the kit and send in some of my DNA and find out where the Finns came from! I'm also intrigued by some claims (elsewhere) that the Finnish language and genes may be as authentic, ancient and unique as that of the Basques.
The image above is of a Gravettian period (22,000 to 28,000 years ago) cave painting in the Czech Republic, photo by Kenneth Garrett, captured from this site.


Just another heads-up. I'm taking possession of my new house on Friday and will be spending a week or so unpacking all my stuff at last.
Have a good time in Hell.
Ain't moving a kick in the teeth and a gonch pull?!
In that Kevin Costner "Robin Hood" flick, the Sheriff of Nottingham wanted to kill Robin with a dull spoon. I thinking of moving as the modern equivalent: slow and painful.
The move is essentially done now...though most of our stuff remains in boxes, and will stay that way till our furniture comes down on a ship this summer.
Don't envision posting much over the next few days, but I'll be loitering around.


Oracle is scrambling to contain the damage from a vulnerability disclosure hiccup that led to the release of a dangerous zero-day flaw in its flagship Database Server product.
The vulnerability, disclosed by researcher Joxean Koret after he mistakenly thought it had been fixed by Oracle, allows an attacker to hijack the information exchanged between clients and databases.
Koret originally reported the vulnerability to Oracle in 2008 (four years ago!) and said he was surprised to see it had been fixed in Oracle's most recent Critical Patch Update without any acknowledgment of his work.
He went ahead and published technicals of the TNS Listener Poison Attack to urge database administrators to apply the patch but, alas, the issue is still unpatched.


Michael BLACKBURN (AUS) continues his lead of the Laser European's in Warnemunde, Germany, overnight adding a further two wins to his score card, putting him 13 points clear of his nearest rival.
The weather forecast for yesterday did not give much hope for sailing all 5 scheduled races for both the Senior and the Youth fleet. However, all the weather systems around Warnemunde did not move as everyone expected and both courses had good sailing conditions with winds of about 15 knots from the west.
There are 101 Senior sailors contesting the event, including Paul GOODISON, the British sailor who has stepped into the spot vacated by Ben AINSLIE and is performing equally well and touted for a medal in Athens, Mark MENDELBLATT (USA) and Hamish PEPPER (NZL) all getting in some final practice before the big event.
Blackburn so far has won four of the six races sailed, discarding a fourth as his drop.
Third placed Maciel GRABOWSKI (POL) won the other two races to finish his day on 20 points. Philipe BERGMANS (BEL) is currently second placed with 20 points.
The Youth fleet of 115 sailors picked up their lost race from Tuesday and also sailed both today's races as well, although had a long day on the water.
Giles SCOTT (GBR) took over the first position from Stephen POWELL (GBR) since the worst score of 6 races can be discarded now.
Today, Thursday is the last qualifier day and after that fleets will be split into Gold and Silver for the finals.


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Elle Fanning Interview Pt. 2 12/19/11
Elle talks about acting at 2 years old, her love of PB&J, Cobb salad, and much more! Part two.
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Thomas Haden Church Interview Pt. 1 12/22/11The Academy Award nominated actor dishes on the celebrity life! Part one.
Thomas Haden Church Interview Pt. 2 12/22/11The Academy Award nominated actor dishes on the celebrity life! Part two.
Elle Fanning Is Obsessed With Cobb SaladElle talks about her painful growth spurt, her early acting gigs, and her obsession with Cobb salad.
Marc Maron Interview Pt. 2 12/21/11When it comes to Christmas gifts, Marc Maron plays the numbers game. Part two.
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Carriera

Club
Birkeland vestì, in carriera, le maglie di Start (per cui giocò anche nella Tippeligaen), Donn, Skeid, Lyngby, Marsala e Kongsvinger. Si ritirò nel 2001, a causa di un infortunio.

Poi cominciò gli studi di giurisprudenza, svolgendo adesso la professione di avvocato.

Nazionale
Birkeland fu convocato nella  per la prima volta nella stagione 1994-1995

Note

Bibliografia

Collegamenti esterni

redpajama_set_name: RedPajamaWikipedia


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Journal of Otology & RhinologyISSN: 2324-8785
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Research Article, Jor Vol: 10 Issue: 4
The Importance of Ki-67, Ck-6 and Ck-16 Expression in the Evaluation of the Destructive Effect and Hyper Proliferative Capacity of Cholesteatoma
Taşdemir Aykut1, Gönüldaş Burhanettin1*, Erkılıç Suna2, Tunç Orhan1 and Kanlıkama Muzaffer1
1 Otorhinolaryngology Head and Neck Surgery, Gaziantep University, Gaziantep, Turkey
2 Pathology Department, Gaziantep University, Gaziantep, Turkey
*Corresponding Author: Burhanettin G
Department of Otolaryngology Head and Neck Surgery, Gaziantep, Turkey
Received date: March 27, 2021; Accepted date: April 12, 2021; Published date: April 20, 2021
Citation: Aykut T, Burhanettin G , Suna E, Orhan T , Muzaffer K (2021) The Importance of Ki-67, Ck-6 and Ck-16 Expression in the Evaluation of the Destructive Effect and Hyper Proliferative Capacity of Cholesteatoma. J Otol Rhinol 10:4.
Objective: Cholesteatoma, with its hyperproliferative feature and destructive pathogenesis, causes bone destruction of the middle ear structures and its surroundings. We aimed to investigate the expression of Ki-67, cytokeratin-6 (CK-6) and cytokeratin-16 (CK-16) in acquired and recurrent cholesteatoma and to correlate them with bone destructive capacity. Materials and Methods: The study was performed as a prospective immunohistochemical study using cholesteatoma tissue (n=45) and external auditory canal skin (n=10) collected during tympanoplasty operation. The findings were recorded considering whether the cholesteatoma was recurrent or not, the extent of cholesteatoma during the operation, ossicular damage and the presence of complications. The patients were divided into 4 groups: Complicated cholesteatoma, recurrent cholesteatoma, uncomplicated cholesteatoma and external auditory canal skin as the control group. Groups were compared in terms of Ki-67 expression level, CK-6 and CK-16 staining patterns. Results: In all groups with cholesteatoma, Ki-67 index was found to be significantly higher than the control group. In addition, the Ki-67 index was found to be significantly higher in the complicated and recurrent cholesteatoma groups compared to the uncomplicated group (p=0.015 and p=0.001, respectively). While CK-6 showed only suprabasal staining on the skin of the external auditory canal, it showed a full-coat staining pattern in cholesteatoma. When the groups with cholesteatoma were compared in terms of CK-16 staining pattern, the only significant result was higher full-thickness staining rates in the recurrent cholesteatoma group compared to the uncomplicated cholesteatoma group (p=0.022) Conclusion: Ki-67 index has been shown to be an important pathological parameter in evaluating the aggressive behavior of cholesteatoma. In addition, our study is the first to show the significant relationship of Ki-67 and CK-16 with recurrent cholesteatomas.
Keywords: Recurrent cholesteatoma; Complicated cholesteatoma; Cytokeratin-6; cytokeratin-16; Ki-67
Cholesteatoma is defined as the abnormal presence of keratinized squamous epithelium in the middle ear cavity and other pneumatized areas of the temporal bone. Cholesteatoma, with its hyperproliferative and destructive properties, causes bone destruction of the middle ear structures and its surroundings. The ossicular chain and bone resorption of the otic capsule can cause hearing loss, vestibular dysfunction, facial paralysis and intracranial complications. There is no single cause of osteoporosis in cholesteatomas. Mechanisms such as pressure necrosis, chronic osteomyelitis, resorption with osteoclast, enzymatic reseorption, local pH changes, and vascular proliferation are thought to play a role in cholesteatoma-related bone resorption [1].
Cholesteatomas show similar features regardless of the underlying pathogenesis; hyperproliferation and differentiation with invasion, increased inflammation [2]. Normally there is a balance between cell proliferation and programmed cell death in keratinocytes. This balance is impaired in cholesteatoma and causes an increase in the accumulation of excessively proliferating epithelial keratin [3]. When the epithelium begins to hyperproliferate, the destructive process begins in cholesteatoma. Studies have been conducted on cytokeratin and Ki-67 to show the hyperproliferative properties of cholesteatoma [4,5].
Cholesteatoma, with its hyperproliferative potential, can lead to destruction in surrounding tissues and related complications, and may present with postoperative recurrences. However, complications do not occur in every patient with cholesteatoma. In this study, we aimed to investigate the expression of Ki-67, CK-6 and CK-16 in acquired cholesteatoma and to reveal the relationship of these markers with destruction and recurrence of cholesteatoma.
The study was conducted as a prospective immunohistochemical study by collecting cholesteatoma tissue (n=45) and external auditory canal skin (n=10) during tympanoplasty operation between February 2015 and September 2018. Ethics committee approval was obtained from the patients by providing information about the study.
During the operation, the extent of cholesteatoma, ossicular chain damage and the presence of complications were recorded. Patients with congenital cholesteatoma were not included in the study. In the study, patients were divided into four groups:
Complicated cholesteatoma (n=15): Patients with at least one clinical complication and findings of intraoperative complications.
Recurrent cholesteatoma (n=15): Patients with previous cholesteatoma surgery but recurrence of cholesteatoma.
Uncomplicated cholesteatoma (n=15): Cholesteatoma with one or more ossicular chain destruction but without complications.
Control group (n=10): The group whose external auditory canal epithelium was sampled from patients operated for chronic otitis media without cholesteatoma.
Immunohistochemical Examination and Evaluation
During the operation, tissue samples were taken for the study froups and placed in 10% formulation and sent to the Pathology Department for immunohistochemical analysis. After the samples taken from all groups were embedded in paraffin, 4 micron thick sections were obtained and placed on a poly-l-lysine coated lam. Lames were initially kept in the oven at 370C for 15 minutes, and then immunohistochemical staining was performed with Ki-67, CK-6 and CK-16 dyes on an automatic staining device (Ventana Bench Mark Ultra, SN:316054). After treatment with primary antibody, it was washed in tap water and covered with an ultra-amount. All samples were evaluated under a light microscope by the same pathologist and researcher. The pathologist and investigator were unaware of the clinical condition of the patients and the study groups during the evaluation of the samples, and the study thus gained a double-blind feature. 100 epithelial cells were counted by evaluating the 3 most stained areas at 200 magnifications under light microscopy and the number of positively stained epithelial cells was determined as the percentage of Ki-67 positive cells. CK-6 and CK-16 staining patterns were determined according to the stained epithelial layers (Figure 1).
Figure 1: (A) Cholesteatoma and external auditory canal skin immunohistochemical staining. Suprabasal layer staining of the external auditory canal skin with CK-6. (B,C) Outer ear canal skin Basal-suprabasal layer staining with CK-16. (D) Basal strength, suprabasal pale staining. (E) Full coat staining of cholesteatoma with CK-16. (F) Staining of the outer ear canal skin with Ki-67. (G) Staining of recurrent cholesteatoma with Ki-67. (H) Staining of complicated cholesteatoma with Ki-67.
The compliance of numerical variables to normal distribution was tested with the Shaphiro-Wilk test. Student's t-test was used to compare variables that fit normal distribution in two groups, and ANOVA and LSD tests were used to compare three groups. Relationships between categorical variables were tested with the Chisquare test. SPSS 22.0 Windows version was used in the analysis. P<0.05 was considered significant.
35 (63.6%) of the patients were male, 20 (36.4%) were female. The average age of the patients included in the study was 33.64 ± 15.61, and their ages ranged from 5-71, and the age distribution by groups was homogeneous.
In the complicated cholesteatoma group, 11 patients had a single complication, and 4 patients had multiple complications. LSSC fistula and facial paralysis were observed in 2 patients, otomastoidevtomy and LSSC fistula in 1 patient (Table 1).
Number of cases
LSSC Fistula 8
Automastoidectomy 4
Fasial paralysis 4
Menengitis 1
Temporal Lobe abscess 1
Table 1: Complication secondary to cholesteatoma.
Ki-67 positive staining percentages according to the groups are given in (Table 2). The Ki-67 index was significantly higher in the complicated cholesteatoma group compared to the uncomplicated cholesteatoma and the control group (p=0.015 and p=0.001, respectively). The Ki-67 index was also found to be significantly higher in the recurrent cholesteatoma group compared to the uncomplicated cholesteatoma and the control group (p=0.001 and p=0.001, respectively). The Ki-67 index was also found to be significantly higher in the uncomplicated cholesteatoma group compared to the control group (p=0.003). No significant difference was found between the complicated cholesteatoma and recurrent cholesteatoma group in terms of Ki-67 index (p=0.157)
Ki-67 (%)
Complicated cholesteatoma(n=15) 62.53 ± 17.36
Recurrent cholesteatoma (n=15) 71.20 ± 21.30
Uncomplicated collesteatoma (n=15) 47.40 ± 13.26
Control group (n=10) 26.30 ± 9.94
Total (n=55) 54.18 ± 22.68
Table 2: Percentage of Ki-67 positive staining by groups.
17 (37.8%) of the patients who were operated for chronic otitis media with cholesteatoma had canal wall up mastoidectomy and 28 (62.2%) had canal wall down mastoidectomy. The Ki-67 index was found to be significantly higher in patients who underwent cholesteatoma surgery with canal wall down compared to those with canal wall up (p=0.009) (Table 3).
Canal wall down (n=28) 66.25 ± 20.39
Canal wall up (n=17) 50.70 ± 15.00
Table 3: Ki-67 positive staining percentage according to surgical technique.
We found that CK-6 has different staining patterns in cholesteatoma and external auditory canal epithelium. CK-6 only had a suprabasal staining pattern in the external auditory canal epithelium of all patients in the control group. No staining was observed in the basal layer. In all patients with cholesteatoma, CK-6 has a full coat staining pattern.
We observed that all patients in the control group of CK-16 had basal and suprabasal staining patterns in the external auditory canal epithelium, but it showed pale staining in the suprabasal layer. We observed that 31 (68.89%) of the patients with cholesteatoma had full coat staining, and 14 (31.11%) had basal and suprabasal staining patterns.
When he froups with cholesteatoma were compared according to the CK-16 staining patterns, we found the only significant relationship between the recurrent cholesteatoma group and the group with uncomplicated cholesteatoma (p=0.022). When complicated cholesteatoma and recurrent cholesteatoma groups were compared in terms of CK-16 staining pattern, p=0.369; When the complicated cholesteatoma and uncomplicated cholesteatoma groups were compared, we obtained p=0.142 statistical value (Table 4).
Complicated cholesteatoma
n (%)
Recurrent cholesteatoma
Uncomplicated cholesteatoma
External auditory canal epithelium
CK-16 staining pattern Basal-Suprabasal staining 4 (26.7%) 2 (13.3%) 8 (53.3%) 10(100%)
Full coat staining 11 (73.3%) 13 (86.7%) 7 (46.7%) 0 (0%)
Table 4: CK-16 staining pattern according to the groups.
When the relationship between the CK-16 staining pattern and the Ki-67 index was compared, the Ki-67 index of the full-coat stains was found to be significantly higher than the basal-suprabasal stains (p=0.001) (Table 5).
CK-16 Basal-Suprabasal staining (n=24) 41.29 ± 20.39
Staining pattern Full coat staining (n=31) 64.16 ± 19.26
Table 5: Percentage of positive Ki-67 staining according to CK-16 staining pattern.
Ki-67 protein is a marker closely related to cellular proliferation. Since this protein is present in all active phases of the cell cycle susch as G1, S, G2 and mitosis, but not in the G0 phase, it is a unique marker in growing and proliferating cells [6]. In previos studies, it wasshown that there is a higher rate of Ki-67 expression in cholesteatoma epithelium compared to normal skin [7-10]. Although there are many literature studies stating that the Ki-67 index is high in cholesteatoma, there are few studies that contradict each other and explain the relationship between Ki-67 index and the destructive behavior of cholesteatoma [11-13]. It can be concluded that the difference in clinical parameters and methodological methods was effective in obtaining different results in these studies. One or more ossicular damage due to chronic inflammation can be seen in patients with chronic otitis media with discharge without cholesteatoma. This situation indicates that one or more ossicular damage is an insufficient parameter in evaluating the aggressiveness of cholesteatoma. Therefore, in our study, we defined cholesteatomas with one or more ossicular chain damage or causing damage in the attic as non-invasive group without complications. According to our experience, we also encounter dehiscences in the facial canal in patients operated for chronic otitis media without cholesteatoma. In an anatomical study conducted by Baxter [14], it was reported that 57% of people had dehiscence in the facial canal at the oval window level. In another study conducted by Moreano et al. [15] on 1000 temporal bones, dehiscence was found in at least one of the facial canals in 56% of the patients. In our study, we based on complications related to cholesteatoma to reveal the invasive character of cholesteatoma. We did not consider facial canal dehiscence alone as a complication. Because facial canal dehiscence alone may be a pre-existing anatomical defect independent of the disease, and accepting it as a complication will lead to a false positive evaluation. Therefore, we considered facial paralysis and facial canal dehiscence in contact with intraoperative cholesteatoma as a clinical complication. Other complications we included in the complicated cholesteatoma group were LSSC fistula, otomastoidectomy, temporal lobe abscess, and meningitis. The high Ki-67 index in cholesteatoma compared to the epithelium of the external auditory canal was consistent with previous studies. In addition, our study provides support that the Ki-67 index is an important pathological parameter in the aggressive behaviour of cholesteatoma. However, there are also factors that limit our study. The most important of these is the period from the onset of cholesteatoma to the emergence of complications. If the patients who are accepted as uncomplicated cholesteatoma are delayed in the diagnosis, it may appear as a complication in the future or does the aggressive behavior of cholesteatoma increase over time? Despite these uncertainties, our study is supported by both previous studies and statistically significant data we obtained.
Although cholesteatoma has been treated surgically, its recurrent nature poses a clinically important problem. Recurrence rates between 5% and 71% have been reported in the literature. The reason for the high difference between rates may be related to type of cholesteatoma, surgical technique, follow-up frequency, postoperative follow-up time and the statistical method applied [16]. In previous studies, no difference was found between recurrent and non-recurrent cholesteatomas at Ki-67 level [17,18]. In our study, contrary to the literature, we found a significantly higher Ki-67 index in recurrent cholesteatomas. We think that the inclusion of more patients in the study and the increase in the sample size and the more detailed grouping of the patients were effective in obtaining results in this way. This study is the first to provide evidence that Ki-67 index may be an important pathological parameter for recurrent cholesteatomas. We can collect recurrent cholesteatomas that develop after surgical treatment of cholesteatomas that develop after surgical treatment of cholesteatoma in two groups as residual and recurrent. Residual cholesteatoma is a cholesteatoma formed by the squamous epithelial tissue remaining in the middle ear. Recurrent cholesteatoma is the recurrence of cholesteatoma despite surgical removal. It is difficult to make a clear statement as to whether these are residual or recurrent cholesteatoma. However, the patients we operated for recurrent cholesteatoma had a canal wall down mastoidectomy in the previous surgery. Based on this, we think that the recurrent cases in our study were mostly recurrent cholesteatoma. Because the possibility of residual canal wall down mastoidectomy is low.
Cytokeratins are one of the most studied markers to reveal the hyperproliferative character of cholesteatoma epitheliumç the distribution of cytokeratins in the epithelium varies according to the cell type, growth, migrationand differentiation stage [19]. Vennix investigated the expression of a group of cytokeratin, including CK-6, CK-16 and CK-17 in cholesteatoma, and revealed different types of staining patterns in cholesteatoma [20]. In our study, we observed that CK-6 showed only suprabasal staining patterns in the epithelium of the external auditory canal, in accordance with the literature. CK-6 expression was not observed in the basal layer. In all patients with cholesteatoma, CK-6 showed a full-coat staining pattern. We found that CK-6 expression, which is a marker associated with hyperproliferation, was increased in cholesteatoma. This result reflects the hyperproliferative behavior of cholesteatoma showed that this marker was not related to the aggressive behavior of cholesteatoma. In our study, CK-16 showed basal-suprabasal staining in the epithelium of the external auditory canal and stained the suprabasal layer pale. We observed that 31 (68.89%) of the patients with cholesteatoma had full-coat staining and 14 (31.11%) had a basal-suprabasal staining pattern. When we compared the relationship between the CK-16 staining pattern and the Ki-67 index, the Ki-67 index of the full-coat stains was found to be significantly higher than the basal-suprabasal stains (p=0.001). We have supported that cholesteatoma has a hyperproliferative character with a positive correlation between the CK-16 staining pattern and the Ki-67 index. When the groups with cholesteatoma were compared in terms of CK-16 staining pattern, the only significant result was a higher rate of full-coat staining patterns in the recurrent cholesteatoma group than the uncomplicated cholesteatoma group (p=0.022). In this study, we provided support proving that CK-16 is a parameter that can be used in the differentiation of recurrent cholesteatomas from non-recurrent cholesteatomas. On the other hand, although the CK-16 staining pattern did not show a statistically significant difference between the complicated cholesteatoma group and the uncomplicated cholesteatoma group, a higher rate of full-thickness staining was observed in the complicated group. Although CK-16 is a hyperproliferative marker, it alone cannot explain the aggressive behavior of cholesteatoma. In our study, we divided the patients operated for cholesteatoma into two groups as surgical technique: Canal wall down and canal wall up. Ki-67 index was found to be significantly higher in patients who underwent cholesteatoma surgery with canal wall down compared to those performed with canal wall up. Although the surgical technique chosen affects the quality of life, this result supports that we make a more accurate surgical technique decision intraoperatively compared to the prevalence of cholesteatoma.
We have shown that Ki-67 index and CK-16 staining pattern are usable parameters in terms of follow-up and prognosis of patients with cholesteatoma. It has been shown that Ki-67 index is an important pathological parameter in evaluating the aggressive behavior of cholesteatoma. In addition, our study is the first study showing the significant relationship of Ki-67 and CK-16 with recurrent cholesteatomas.
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Huisman MA, De Heer E, Grote JJ (2003) Cholesteatoma epithelium is characterized by increased expression of Ki-67, p53 and p21, with minimal apopitosis. Acta Otolaryngol 123: 377-82.
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Chae SW, Song JJ, Suh HK, Jung HH, Lim HH, et al. (2000) Expression patterns of p27kip1 and ki-67 in cholesteatoma epitelium. Laryngoscope 110:1898-1901
Hamed MA, Nakata S (2017) Cytokeratin 13, Cytokeratin 17, and Ki-67 expression in human acquired cholesteatoma and their correlation with its destructive capacity. lin Exp Otorhinolaryngol 10: 213-220.
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Şanlı A, Tezer İ, Paksoy M, Aydın S, Hardal Ü, et al. (2007) Tekrarlayan kolesteatomlu olgularda Ki-67 ekspresyonunun değerlendirilmesi. Kulak Burun Bogaz Ihtis Derg 17: 65-69
Olszewska E, Sudhoff H (2007) Comparative cytokeratin distribution patterns in cholesteatoma epithelium. Histol Histopathol 22: 37-42.
Vennix PP, Kuijpers W, Peters TA, Tonnaer EL, Ramaekers FC, et al. ( 1996) Keratinocyte differentiation in acquired cholesteatoma and perforated tympanic membranes. Arch Otolaryngol Head Neck Surg Aug 122: 825-832.
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Journal of Otology & Rhinology peer review process verified at publons
9th International Conference on Otology, Rhinology and Laryngology
7th International Conference on Otolaryngology and ENT
Geriatric Otorhinolaryngology
Head and Neck Surgery
Hearing Loss and Balance Disorders
Neurotology
Oral and Neck Oncology
Pediatric Otorhinolaryngology
Sinus Disorders
Sleep Apnea disorders


The aircraft carrier is truly a marvel of science and engineering.
Backbeat Brings Original 5th Beatle's Tale To Blu-ray In Feb.
The 5th Beatle's Story Told!
The week after Masaaki Yuasa's The Night is Short, Walk On Girl arrives on Blu-ray, his Lu Over the Wall arrives.
Don't you hate it when you've completely missed out on something and discover it 20 years after its initial release?


My Dell Inpirion 1000 Laptop was working great one day and will not power on the next day.
The battery and power cord are good.
The laptop would not turn on. Green lights flash for a second...then completely off, but nothing happens.
The fan does not even start.
I am NOT able to boot into Windows to see the Dell screen when it is trying to boot.
I do hear the hard drive start and stop. but nothing happens.
So which one of these could be problem? motherboard, memory, or processor?
How do I troubleshoot to find out which one is the problem without spending whole a lot of money?
Any suggestions would be greatly appreciated!!! Thanks!!
Doesn't sound like a CPU overheating issue if the laptop powers up for a second and then shuts back down right away. Is it possible that a screw or something metal got dislodged and is now shorting out the system?


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"Let today be the start of something new!"
Today is the first day of the 2017-18 school year! It has already been filled with excitement and energy. Not only did I send my oldest daughter off to her first day of first grade, but I began welcoming students into the school for my 13th year as an educator. The morning was filled with happiness and enthusiasm for what this year may hold.
With the beginning of each new year as a teacher (and teacher-mom) I am filled with wonders, worries, ideas, plans, and motivation. I love everything "back-to-school" - the school supplies, new school shoes and clothes, the wait for finding out who your new students, teacher or classmates might be, etc... But what I love most about "back-to-school" is the possibility. Each new year brings with it new opportunities for teachers and students. It is the start of something new, a blank page waiting to be filled.
As we fill the upcoming days with tasks such as unpacking school supplies, labeling desks, sharing procedures, taking tours of the school and classroom community building activities, don't forget that you are a difference maker. At the start of the school year, you are the one that sets the tone for your students. You are the one helping them write the first words on their new, blank page for the 2017-18 school year. You are their new opportunity. Help your students see the new possibilities ahead of them. Help them embrace the new challenges and experiences that each new school year brings. Be the reason they are smiling, laughing, learning and growing.
You are ready, they are here...let's get this party started!


text:
Fiji says call for elections 'obsessive'
By Jonathan Pearlman and Josephine Tovey
April 15, 2009 — 12.00am
FIJI'S military regime has criticised Australia for being "obsessed" with elections and rejected Kevin Rudd's description of the Fijian leadership as a virtual military dictatorship.
The interim Attorney-General, Aiyaz Sayed-Khaiyum, yesterday dismissed the push by Australia and New Zealand to strengthen regional diplomatic sanctions, saying elections should not be held until the electoral laws had been changed to allay ethnic and provincial tensions.
"Rudd and [the Foreign Minister, Stephen] Smith and New Zealand are essentially obsessed with elections," he told the Herald.
"The people of Fiji do not want to hold elections for the sake of holding elections to satisfy Australia and New Zealand, if the credibility of the elections are in doubt … Because [Fiji has] a commander of the military forces who is also a prime minister does not make it a military dictatorship."
Commodore Frank Bainimarama, who came to power in a coup in 2006, had indicated he would hold elections by this year but said he wanted first to introduce changes to allay tensions between the indigenous majority and the ethnic Indian minority. A court ruling last week that declared his regime illegal was ignored by the President, Ratu Josefa Iloilo - a loyal supporter - who sacked the judiciary, dissolved the constitution, declared a 30-day state of emergency and set back the election deadline to 2014.
Fiji's military regime yesterday extended its crackdown beyond the media to the legal and financial sectors, including the arrest of the Law Society president, Dorsami Naidu, and the sacking of the Reserve Bank governor, Savenaca Narbue. The regime also moved to tighten foreign exchange controls and limit the flow of capital.
The regime said the officials had been removed because their positions depended on the constitution, which had been dissolved. Several of these officials are expected to be replaced by figures regarded as friendly to the regime.
This week the regime has censored media, arrested a television reporter and deported several foreign journalists, including ABC reporter Sean Dorney, who arrived back in Australia yesterday.
Dorney, who had refused an offer to leave voluntarily, said he had his phone confiscated and was detained in a room for five hours at official headquarters before he was deported.
"We were not roughly treated but they did insist on having a look at all our cameras and having a look at what we'd shot," he said.
Mr Sayed-Khaiyum said the police had been acting under the state of emergency measures.
"We do not want any misinformation broadcast," he said.


One day I'm going to take a stand against the division of time into arbitrary regular periods. It's a delusion anyway. The periods aren't regular – I've noticed throughout my life that they grow consistently shorter. A year is a trivial amount of time now. On current trends, by the time I'm 80 one will last about as long as a summer's afternoon did when I was five. No doubt it's healthy to stop and take mental stock every so often, but marking every single year that comes along feels like indulging them.
But then again, without this end-of-the-year show it could easily have escaped my ephemeral notice that 2011 was an extraordinary one. I doubt if we've had so much change – especially so much hopeful change – since at least 1989. In some ways we've seen the anti-2001; the greatest act of terrorism was carried out by a Christian extremist, the people fighting for democracy were Muslim. It went a long way towards repairing the damage perpetrated during the miserable presidency of George W. Bush.
Except of course that done to the world economy, which is still utterly buggered. At least people rioted in the UK. Yeah, I see that as a positive. If we create a society where the rich can blow it all gambling yet somehow still stay rich, meanwhile telling the poor that they have to be poorer now, then it is a good thing that some people say "OK, we're not playing by these rules anymore". This isn't justifying theft, it's pointing out that societies are made out of people and you can't keep taking the piss.
Similarly I think the riots against austerity in the Eurozone were on balance a good thing. I'd sooner peaceful civil disobedience like the Occupy movements, but a riot is the next best thing. Certainly, either is better than the supine attitude we seem to have adopted in Ireland.
This then is my greatest hope and fear for 2012. How will we channel our anger? Here in Galway, city councillors are trying to close the little Occupy encampment that we have on the grounds that it's bad for business. That is how much our politicians care for actual politics. Every challenge to the system in the last ten years, from organised terrorism to music downloading, has been used by the powerful as an excuse to give themselves yet more power over the individual. There are real threats in the world to democratic capitalism, it is true. The greatest is from undemocratic capitalism.


My awesome project incorporates a virtual reality painting station for the public to use during our gallery showings! We have a mobile gallery that has done shows from California to Nevada, this month we will have shows in San Jose and end in Oregon, yet most of our shows are based in San Jose, we have continuously participate in First Fridays and SubZERO festivals for years. Our exhibitions feature art from emerging artist as well as offering a platform for theater and performances. We offer listening stations and a coloring decompression area for adults and children. We would love to incorporate a VR painting station into our gallery for the public to experience the awesomeness of virtual reality! But not just any old VR will do, we want to use VR with tactile response and a program that enables users to paint in 3D!
Our virtual reality painting station would be like a listening station but outfitted with VR gear that is easy and intuitive to use. Once the gear is slipped on, a person is inside a virtual reality world with a set of brushes, tools, colors, and textures that can be used to create anything that person can think of. Imagine it like a blend of sculpting and painting in thin air, that's the type of wonder we want people in San Jose to experience!
Yes, we want our gallery to feature a 3D Virtual Reality painting Station in order to explore new realms of creativity in three dimensions! it will be the first of its kind in San Jose available to the public. Imagine walking onto the hard wood floors of our gallery, then sliding on the 3D gear and having the ability to paint the space around you, the power to literally paint a cloud above you, the ground below you, and what ever your heart desires in front of you! This is the goal of our project, it will add to the experience of our mobile gallery and be enjoyed by thousands! With your help, we can make the joy of painting in virtual reality a reality!


text:
Americas|A Mexican Governor's Race Carries Presidential Implications
A Mexican Governor's Race Carries Presidential Implications
Andrés Manuel López Obrador, leader of the leftist National Regeneration Movement in Mexico, is a front-runner in early polling for next year's presidential election.CreditCreditHenry Romero/Reuters
By Kirk Semple
The allegations have been flying fast in the bitter campaign to lead Mexico's most populous state. Vote buying. Payoffs. Alliances with rogues. The illegal use of public funds. The flexing of Mafia-style muscle.
In other words, it's business as usual in the State of Mexico, where control of the governor's office, up for grabs every six years, is the biggest prize of all state contests.
The outcome of the race has long been considered a bellwether for the presidential election, providing the victorious party with momentum, campaign money and political influence over the largest state in the country. And this year that seems especially true.
For more than 80 years, the governor's office in the State of Mexico has been under the control of the centrist Institutional Revolutionary Party, or P.R.I. And with each victory, the party has reaffirmed the state as its central political bastion. Its candidate won the last election, in 2011, with more than 61 percent of the vote.
But this year, the race is shaping up to be perhaps the closest ever, possibly foreshadowing a similarly tight contest next year in the race to succeed President Enrique Peña Nieto, a member of Institutional Revolutionary Party.
His deeply unpopular tenure, limited to a single six-year term by Mexican law, is weighing heavily on the party's bid to retain both the State of Mexico governor's office and the presidency.
That the Institutional Revolutionary Party is fighting for its life in the State of Mexico is even more significant because Mr. Peña Nieto is a native of the state and was its governor before winning the presidency.
But unbridled corruption, weak economic growth, soaring violence and the government's own halting response to President Trump's aggressive stance toward the country have eroded support for the Mexican president and his party, helping the political opposition improve its chances at the polls.
The biggest beneficiary so far, it appears, has been the leftist National Regeneration Movement, or Morena, led by the populist agitator Andrés Manuel López Obrador. He has tried to harness nationalist animus toward Mr. Trump by criticizing Mr. Peña Nieto's handling of the American president and casting himself as a strong defender of Mexican sovereignty.
Mr. López Obrador, 63, is a front-runner in early polling for next year's presidential election, and his momentum has helped to advance his party's candidates at the regional level.
In the State of Mexico campaign, two polls released late last month showed his party's candidate, Delfina Gómez Álvarez, 54, taking a thin lead over the Institutional Revolutionary Party's candidate, Alfredo del Mazo Maza, 41.
The election is on June 4. Campaigns for governor are also being waged in the states of Coahuila and Nayarit, but in the State of Mexico the stakes — and the spoils — are far greater.
"It would be a big, big, big loss for the P.R.I.," said José Merino, a political analyst in Mexico City. The impact of a defeat on the party's bid to retain the presidency could be profound, he said.
"It wouldn't be checkmate, but it would be check," Mr. Merino said.
The State of Mexico wraps around Mexico City and has absorbed most of the capital region's stunning population growth in recent decades. It is in some ways a microcosm of the country, embodying its extreme socioeconomic contradictions.
"It's a very, very diverse state," said Vidal Romero, head of the political science department at the Autonomous Technological Institute of Mexico. "It has places with a lot of wealth — individuals, companies, industries — and it has places with enormous poverty."
The state is home to more than 16 million people, about 14 percent of the nation's population, and its economy ranges from manufacturing to commerce to agriculture, its landscape from mountains to slums.
Like the nation as a whole, the State of Mexico has also been wrestling with rising violence and unremitting corruption, which Mr. del Mazo's opponents have used to bludgeon him and his party.
They have also cast him as the epitome of political privilege, a person whose victory at the polls would only perpetuate the clubby, dynastic control of the nation's most powerful offices. In addition to being the son and grandson of former State of Mexico governors, Mr. del Mazo is Mr. Peña Nieto's cousin.
To drive that point home, Josefina Vázquez Mota, 56, the candidate of the conservative National Action Party, regularly refers to Mr. del Mazo as "the president's cousin" in lieu of his name.
"Today, because of the P.R.I., because of the excesses of the same families as always, we are in first place in insecurity, in corruption and also in feminicide," Ms. Vázquez Mota said during a recent televised debate.
While the election is widely viewed as a referendum on the Institutional Revolutionary Party's recent performance, it is also the biggest test yet of the viability of Morena.
Morena was founded in 2014 by Mr. López Obrador, a former mayor of Mexico City and two-time presidential candidate, who has cast himself as the new leader of the political left. His populist message takes aim at the ruling elite and the nation's rampant corruption, violence and inequality.
While his party failed to win a governorship in last year's elections, it performed strongly in the three races it contested and won seats in local elections. A victory in the State of Mexico would provide an outsize accelerant to the party's national ambitions, analysts said.
Its candidate, Ms. Gómez, 54, is a former director of a large grade school who entered politics only recently, in 2012, becoming mayor of her hometown and then a congresswoman. The daughter of a construction worker, she has been embraced by voters who identify with her humble origins and see her relative inexperience in politics as an advantage.
"Her image is impeccable for her fans: a woman from a working-class neighborhood," said Fernando Dworak, a political analyst in Mexico City.
But looming over her candidacy like a puppet master is Mr. López Obrador.
He has occasionally joined Ms. Gómez on the campaign trail, and the disparity in their allure and fame is immediately apparent: the ovations for him are louder, the crowds that surround him more passionate. He is greeted with chants of "President! President! President!"
Mr. López Obrador has explicitly tied the State of Mexico campaign to his push for president.
Speaking at a campaign rally for Ms. Gómez in Cuautitlán, a small city north of the capital, Mr. López Obrador said a victory in the State of Mexico would be "a link in the chain that's being constructed to pull Mexico from backwardness, to pull the people from poverty."
But two videos published in late April by El Universal newspaper supposedly showed a Morena candidate for a mayoralty in Veracruz State accepting stacks of cash on behalf of Mr. López Obrador's campaign, in violation of electoral laws. The candidate immediately ended her campaign, and Mr. López Obrador called the episode a setup to discredit him and his party.
The federal office that examines campaign conduct has been fielding scores of allegations of impropriety. As of April 15, officials had opened 164 investigations — nearly double the number of cases at the same point in the 2011 campaign for governor.
Opposition parties have accused the Peña Nieto administration of meddling in the campaign, including dispatching cabinet members on more than 100 visits to the state in recent months — more than usual, they say — to promote various government projects and benefits. The Institutional Revolutionary Party leadership has denied charges of malfeasance and said all the visits were legal and part of the government's efforts to provide public services.
On a recent afternoon, as the three leading campaigns paid parallel visits to the municipality of Naucalpan, on the northwestern border of Mexico City, the Institutional Revolutionary Party's electoral machinery was particularly evident.
Early in the afternoon, several hundred people turned out in a working-class neighborhood to see Ms. Gómez and Mr. López Obrador speak from a stage under a tent that had been wedged between some buildings and a septic stream littered with garbage. The response was enthusiastic but restrained.
Later in the day, the caravan of the conservative party's candidate, Ms. Vázquez Mota, rolled into another working-class neighborhood, where several hundred people had gathered under a tent. There was a large band on stage, a separate percussion ensemble, seven stilt walkers, a professional wrestler wearing a mask and a nearly nude carnival dancer. Still, much of the audience was quiet, even somnolent.
The Institutional Revolutionary Party, however, took its show to another level. In a middle-class neighborhood, even in the middle of a work day, several thousand people gathered under an enormous tent that covered more than half a soccer field. The crowd was a sea of campaign signs, banners and balloons; many attendees wore the party's colors or paraphernalia.
Half an hour before the event, the chants and raucous anticipation were audible from blocks away.
Mr. del Mazo's arrival was greeted with a sustained, deafening roar from the crowd and the rumble and pop of at least two percussion ensembles. Someone fired a gun that shot a giant plume of confetti.
Even as the candidate began his stump speech, wave upon wave of drumming and chanting cascaded over him for several minutes, forcing him to pause.
"Alfredo! Alfredo! Alfredo" the crowd thundered. "We're going to win! We're going to win!" And at that moment, in that place, there was nothing to suggest they were wrong.
A version of this article appears in print on , Section A, Page 8 of the New York edition with the headline: A Bigger Prize Hangs On a Mexico State Vote. Order Reprints | Today's Paper | Subscribe


Staying at an All Inclusive resort is somewhat of an other-worldly experience.
For one, you're being waited on hand and foot. For two, you're staying on a luxurious property with amazing food, beautiful design, expansive pools and more. And, for three, you're just steps away from the ocean and beach.
Being someone who works in the travel industry, I visit these properties quite frequently. Now, one might think that they'd get progressively less impressive and exciting — but it's actually the opposite. Each time, I'm completely awestruck.
So, if you've never stayed at an All Inclusive resort (something you should definitely do in 2018), this is what you should expect.
1. You feel like royalty the second you walk in.
From the moment you walk in, you'll be bombarded by complete luxury, breath-taking design, beautiful smells, delicious drinks and more. It's amazing.
2. You're blown away by all the beautiful decor.
The thought that goes into every aesthetic detail of the resort will absolutely blow you away.
3. You may stay in a room with a private swim-out pool.
If you opt for a swim-out suite, you'll have unlimited access to a private pool that's connected to your room.
4. You find a spot and claim it as your own.
And you'll never want to leave.
5. You're awestruck by the pools.
The pools at these resorts are — excuse the expression — off the freaking chain. From infinity pools, to pools with swim-up bars, to pools for relaxation, there's something for everyone.
6. You'll want to redecorate your house to look like your hotel room.
Because the detail that goes into creating each room is amazing.
7. You may stay in a room with a Jacuzzi on the balcony.
A lot of rooms will have a Jacuzzi on the balcony. And, trust me, a bath with a view is the literal best thing.
8. You become best friends with the staff and bartenders.
The people who run and work at the resorts are some of the nicest you'll meet. By the end of your stay, you'll have made a few new friends.
9. You want to live in a cabana.
Because lying on an outdoor bed while listening to the ocean waves is amazing.
10. …and nap on every couch.
That's allowed on vacation, right?
11. You have a hard time choosing between restaurants.
Do you choose the steak place? Or the seafood place with the amazing view? Or do you want pizza?
12. You take a million photos of the beach and the ocean.
Because the beach is the real star of the show.
13. You go on the best excursions.
From kayaking, to booze cruising, to snorkeling, to zip-lining — you'll have the time of your life.
14. You will never want to leave.
15. You find sand in everything when you leave.
So, ready to visit an All Inclusive resort? We can help!


text:
Q: Running test for maven project in Gitlab CI/CD I have a project on gitlab and i would like to set up tests using gitlab CI/CD
My project structure is:
.
├── project
│   |── src
|   └── pom.xml
├── .gitlab-ci.yml
└── Licence.txt

My .gitlab.ci.yml script looks like:
image: maven:3.5.3

cache:
  paths:
    - .m2/repository/
    - target/

build:
  stage: build
  script:
    - mvn -f project/pom.xml compile

test:
  stage: test
  script:
    - mvn -f project/pom.xml test

My project has maven dependencies. But running this i recieve error:
[ERROR] To see the full stack trace of the errors, re-run Maven with the -e switch.
[ERROR] Re-run Maven using the -X switch to enable full debug logging.
[ERROR]
[ERROR] For more information about the errors and possible solutions, please read the following articles:
[ERROR] [Help 1] http://cwiki.apache.org/confluence/display/MAVEN/ProjectBuildingException
[ERROR] [Help 2] http://cwiki.apache.org/confluence/display/MAVEN/UnresolvableModelException
Running after_script
Uploading artifacts for failed job
ERROR: Job failed: exit code 1

This looks like it wants to upload my maven artifact into remote repository or something.
What does it mean and how can ifixt this?
Thanks for help!

redpajama_set_name: RedPajamaStackExchange


text:
Otto Abel Harbach, né Otto Abel Hauerbach le  à Salt Lake City et mort le  à New York, est un parolier et librettiste américain qui a composé une cinquantaine de comédies musicales et écrit nombre de musiques de film.

Biographie

Otto Harbach est né de parents immigrés danois.

Parmi ses chansons les plus célèbres figurent Smoke Gets in Your Eyes et .

Comédies musicales
 1925 : No, No, Nanette
 1927 : Lucky, musique de Jerome Kern, lyrics et livret d'Otto Harbach
 1933-1934 : Roberta, musique de Jerome Kern, lyrics et livret d'Otto Harbach
 1936 : Forbidden melody , musique de Sigmund Romberg, création au New Amsterdam Theatre

Musiques de film
 1928 : Rose-Marie
 1929 : Le Chant du désert (The Desert Song)
 1935 : Roberta
 1943 : Le Chant du désert (The Desert Song)
 1952 : Les Rois de la couture
 1954 : Au fond de mon cœur

Liens externes

Parolier américain
Naissance en août 1873
Naissance dans le territoire de l'Utah
Naissance à Salt Lake City
Décès en janvier 1963
Décès à New York
Admis au Songwriters Hall of Fame
Étudiant du Knox College (États-Unis)
Décès à 89 ans


text:
National Groups (NG)
A National Group of IABSE, according to the By-laws, consists of all members of the Association within one country.
The National Groups are, in their field of influence, responsible for the active support of the objectives of the Association. They support the Association in particular through the nomination of qualified members for election to the different committees of the Association. They may have their own activities, such as conferences, and publications.
The National Groups of IABSE have no statutory function according to the By-laws. However the Chairs of the National Groups advise the President of the Association at meetings called and chaired by the President.
The organisation of National Groups varies considerably from country to country.
Is there a National Group in your country?
Below are the steps in forming a National Group:
A founding meeting of at least 6 IABSE members residing in your country should be organized as the first National Group meeting. The Minutes must be submitted to the IABSE Secretariat to the attention of the Executive Director.
Minutes should include the following;
- Date, time and place of the meeting - List of participants with signatures present at the meeting (IABSE members and non-members as guests) - Group pictures if possible to be used for the Newsletter, SEI Article and Social Media - Mission and vision of the new National Group - Plan of future activities - Elected group officials i.e. Chair, Secretary etc..
For more information please contact: secretariat@iabse.org or +41 43 633 26 49