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Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study
Dan Wang1,
Ruifang Li1,
Juan Wang2,
Qunqun Jiang3,
Chang Gao1,
Juan Yang1,
Lintong Ge1 &
Qing Hu ORCID: orcid.org/0000-0002-1041-16421
Coronavirus disease 2019 (COVID-19) is a novel infectious disease caused by the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) emerged in Wuhan and has quickly spread across the world. The mortality rate in critically ill patients with COVID-19 is high. This study analyzed clinical and biochemical parameters between mild and severe patients, helping to identify severe or critical patients early.
In this single center, cross-sectional study, 143 patients were included and divided to mild/moderate and sever/critical groups. Correlation between the disease criticality and clinical features and peripheral blood biochemical markers was analyzed. Cut-off values for critically ill patients were speculated through the ROC curve.
Significantly, disease severity was associated with age (r = 0.458, P < 0.001), comorbidities (r = 0.445, P < 0.001), white cell count (r = 0.229, P = 0.006), neutrophil count (r = 0.238, P = 0.004), lymphocyte count (r = − 0.295, P < 0.001), albumin (r = − 0.603, P < 0.001), high-density lipoprotein cholesterol (r = − 0.362, P < 0.001), serum potassium (r = − 0.237, P = 0.004), plasma glucose (r = 0.383, P < 0.001), total bilirubin (r = 0.340, P < 0.001), serum amyloid A (r = 0.58, P < 0.001), procalcitonin (r = 0.345, P < 0.001), C-reactive protein (r = 0.477, P < 0.001), lactate dehydrogenase (r = 0.548, P < 0.001), aspartate aminotransferase (r = 0.342, P < 0.001), alanine aminotransferase (r = 0.264, P = 0.001), erythrocyte sedimentation rate (r = 0.284, P = 0.001) and D-dimer (r = 0.477, P < 0.001) .
With the following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.
A novel coronavirus, designated as the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), was first identified in Wuhan, China in December 2019 [1]. SARS-CoV-2 is highly infectious and asymptomatic patients may also become the source of infection [2]. World Health Organization (WHO) announced that the disease caused by SARS-CoV-2 was coronavirus disease 2019 (COVID-19) on February 11, 2020. Patients with COVID-19 have a series of clinical manifestations, such as pharyngalgia, fever, cough, fatigue, anorexia, headache, diarrhea, nausea or vomiting, dyspnea [3], even acute respiratory distress syndrome (ARDS). A lot of severe or critical patients had to been admitted to the intensive care unit (ICU). According to the reported clinical characteristics of patients with COVID-19, the total mortality ranges from 2 to 5%, which can be even higher in the elders [4]. Wuhan city, as the epidemic area, the mortality reached a peak of over 7% at the early stage [5].
Although most patients with COVID-19 were mild in the early days, some patients progressed rapidly to acute respiratory failure, metabolic acidosis, septic shock, ARDS or death. Early identification of risk factors for critical patients could facilitate appropriate supportive care and thus reduce the mortality [6]. A study of the first 138 laboratory-confirmed cases with COVID-19 showed the changes of neutrophil count, lymphocyte count, and D-dimer levels [7]. Increased inflammation -related indicators were found in patients with COVID-19, including erythrocyte sedimentation rate (ESR), interleukin-6 and C-reactive protein (CRP) [4]. However, little is known about the relationship between disease severity and clinical and biochemical features in patients with COVID-19.
In this study, we performed a comprehensive evaluation of characteristics of 143 patients with COVID-19 admitted to Hubei NO.3 People's Hospital of Jianghan University, Wuhan. This study retrospectively analyzed clinical characteristics and biochemical parameters between mild/moderate and severe/critical patients, which may help to identify critical cases and perform appropriate clinical intervention early.
This study was a cross-sectional study, and all consecutive patients with confirmed COVID-19 admitted to Hubei NO.3 People's Hospital of Jianghan University from January 15, 2020 to February 28, 2020, were enrolled. Hubei NO.3 People's Hospital of Jianghan University, located in Wuhan, Hubei Province, the endemic areas of SARS-CoV-2, is one of the major public hospitals and is responsible for the treatments for COVID-19 assigned by the government. Diagnosis of COVID-19 and clinical classification according to the new coronavirus pneumonia diagnosis and treatment plan (trial version 7) developed by the National Health Commission of the People's Republic of China [8].
The clinical classifications are as follows: (1) mild, minor symptoms and imaging shows no pneumonia. (2) moderate, with fever, respiratory tract symptoms, and imaging shows pneumonia. (3) severe, meet any of the following: a) respiratory distress, respiratory rate ≥ 30 beats/min; b) in the resting state, means oxygen saturation ≤ 93%; c) arterial blood oxygen partial pressure/oxygen concentration ≤ 300 mmHg (1 mmHg = 0.133 kPa); d) pulmonary imaging showed that the lesion progressed more than 50% within 24–48 h. (4) critical, one of the following conditions: a) respiratory failure occurs and requires mechanical ventilation; b) Shock occurs; c) ICU admission is required for combined organ failure.
In this study, the patients with mild or moderate symptoms were classified as mild/moderate group, and the patients with severe or critical symptoms were classified as severe/critical group. The assessment of disease severity and laboratory tests were performed at the same time on the day of inpatient admission before treatment.
All suspected infection patients were taken upper respiratory throat swab samples at admission and then shipped to designated authoritative laboratories to detect the SARS-CoV-2. Bacterial and fungal detections of sputum or respiratory secretions and other laboratory tests were completed in the clinical laboratory in Hubei NO.3 People's Hospital of Jianghan University. C-reactive protein (CRP) was detected by immunoturbidimetry method. Procalcitonin (PCT) was detected by Roche electrochemiluminescence method. Erythrocyte sedimentation rate (ESR) was measured by Westergren's international standard method.
We retrospectively analyzed and evaluated the epidemiological history, comorbidities, vital signs, and symptoms obtained from electronic medical records. The data collection forms were reviewed independently by two experienced physicians. These patients have not been reported in any other submission by anyone.
Categorical variables were given as frequency rates and percentages; continuous variables were defined using mean, median, and interquartile range (IQR) values. The Kolmogorov-Smirnov test was used to verify the normality of distribution of continuous variables. The independent sample t test or the Mann-Whitney U test was used for the continuous variables and the chi-square test for the categorical variables. In correlation analysis, Pearson correlation coefficient was used for the variables of normal distribution and Spearman correlation coefficient for those of skewed distribution. Receiver–operating characteristic (ROC) curve analysis was used to determine the optimum cut-off points of parameters for severe patients. Statistical analyses were performed using SPSS 24.0 (SPSS Inc., Chicago, IL, USA) and MedCalc 19.0.4. A 2-tailed P < 0.05 was considered as statistically significant.
The study population included 143 hospitalized patients with confirmed COVID-19. The median age was 58 years (IQR, 39–67; range, 14–84 years), and 73 (51.0%) were men. Of the 143 patients, 50 (35.0%) had 1 or more comorbidities. Hypertension (36 [25.2%]), cardiovascular disease (16 [11.2%]) and diabetes (13 [9.1%]) were the most common coexisting conditions. The most common symptoms at initial stage of illness were fever (137 [95.8%]), fatigue (93 [65.0%]), dry cough (78 [54.5%]), anorexia (66 [46.2%]), chest tightness (63 [44.1%]), myalgia (49 [34.3%]), mild shortness of breath (48 [33.6%]), chill (33 [23.1%]) and dyspnea (31 [21.7%]). Less common symptoms were nausea or vomiting, diarrhea and headache (Table 1). X-ray or CT showed multiple lung lobes or bilateral involvement in 138 (96.5%) patients. Figure 1 showed the CT images of a typical patient in early, consolidation, absorption and dissipation stages.
Table 1 Demographics and baseline characteristics of patients with COVID-19
A patient with severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) infection. a Ground glass shadow in multiple lobes and segments of bilateral lungs, and the lesions were adjacent to the pleura (Illness Day 7, Hospital Day 0). b Ground glass shadow expanding and consolidation in bilateral lung (Illness Day 12, Hospital Day 5). c Ground glass shadow absorption and reduced consolidation area (Illness Day 18, Hospital Day 11). d Lesion dissipation (Illness Day 24, Hospital Day 17)
Compared with the mild/moderate group (n = 72), the severe/critical group (n = 71) were significantly older (median age, 65 years [IQR, 53–69] vs 44 years [IQR, 32–60]; P < 0.001) and were more likely to have underlying comorbidities, including hypertension (31 [43.7%] vs 5 [6.9%], and cardiovascular disease (12 [16.9%] vs 4 [5.6%]). Compared with the mild/moderate group, the severe/critical group were more likely to report anorexia, expectoration, mild shortness of breath, dyspnea and myalgia.
There were numerous differences in laboratory findings between mild/moderate group and severe/critical group, including white blood cell, neutrophil count, and lymphocyte count, as well as levels of high-density lipoprotein cholesterol (HDL-C), plasma glucose, serum potassium, total bilirubin (TBIL), albumin, aspartate aminotransferase (AST), alanine aminotransferase (ALT), lactate dehydrogenase (LDH), D-dimer, erythrocyte sedimentation rate (ESR), serum amyloid A (SAA), C-reactive protein (CRP) and procalcitonin (PCT) (Table 2).
Table 2 Laboratory findings of patients with COVID-19 on admission to hospital
Significant correlations were found about age, comorbidities, white blood cell count, neutrophil count, lymphocyte count, plasma glucose, serum potassium, albumin, D-dimer, HDL-C, TBIL, AST, ALT, LDH, ESR, SAA, CRP and PCT. Strikingly, this analysis revealed negative correlation between disease severity and lymphocyte count, albumin, serum potassium, and HDL-C (Table 3). Age (r = 0.458), comorbidities (r = 0.445), LDH (r = 0.548), D-dimer (r = 0.477), SAA (r = 0.58), CRP (r = 0.477) were moderately correlated and albumin (r = − 0.603) was highly correlated.
Table 3 Correlation coefficient and P value between items and disease severity
To better detect the severe illness, the ROC curve of age was administrated and listed in Fig. 2a (AUC = 0.746, 95% CI: 0.686–0.831, P < 0.001). The best cut-off point of age was 52 years with a sensitivity of 76.1% and specificity of 63.9%. The ROC curve of LDH (AUC = 0.816, 95% CI: 0.743–0.876, P < 0.001, Fig. 2b) suggested the best cut-off point was 245 U/L with a specificity of 69.4% and a sensitivity of 85.9%. The ROC curve of D-dimer (AUC = 0.775, 95% CI: 0.698–0.841, P < 0.001, Fig. 2c) suggested the best cut-off point was 0.96 μg/mL with 77.0% specificity and 78.1% sensitivity. The ROC curve of SAA (AUC = 0.835, 95% CI: 0.764–0.892, P < 0.001, Fig. 2d) indicated the best cut-off point was 100.02 mg/L with 72.2% specificity and 85.9% sensitivity. The ROC curve of albumin (AUC = 0.848, 95% CI: 0.779–0.903, P < 0.001, Fig. 2e) indicated the best cut-off point was 36 g/L with a specificity of 83.3% and a sensitivity of 85.9%. The ROC curve of CRP (AUC = 0.776, 95% CI: 0.698–0.841, P < 0.001, Fig. 2f) suggested the best cut-off point was 64.79 mg/L with a specificity of 81.9% and a sensitivity of 64.8%.
ROC curve of indicators between mild/moderate and severe/critical. a age; b LDH; c D-dimer; d SAA; e Albumin; f CRP
The area under the ROC curve for albumin was the biggest (AUC = 0.848), and the area under the ROC curve for SAA ranked second (AUC = 0.835). The calculated difference between the AUC for albumin and the AUC for SAA was 0.013, but it was not statistically significant (P = 0.787). Binary logistic regression was applied to calculate the predictive probability of combined indicators for the speculation of disease severity. The combined indicators found that the AUC reached 0.921 (95% CI: 0.864–0.959, P < 0.001, Fig. 3a), with a sensitivity of 87.3% and a specificity of 80.6%. The area difference between the combined indicators and albumin was 0.0726 (95% CI: 0.0125–0.133, P = 0.0179, Fig. 3b), indicating that the accuracy of the combined identification of the six indicators was the best.
ROC curve of combined indicators for the speculation of disease severity
The SARS-CoV-2 outbreaking at the end of 2019 is highly contagious and more than 80,000 patients have been reported in Chinese mainland [9]. The number of confirmed cases worldwide has risen by 7499 to 132,758, among which nearly 28,900 were reported in the European region [10]. Most patients are mild to moderate severity, and with a better prognosis [11]. However, for patients developing into severe or critical levels, the mortality rate was markedly higher. It is important to identify critically ill patients even earlier, aiming to reduce mortality and improve the recovery rate.
In this study, the relationship between disease severity and clinical and biochemical indicators was comprehensively analyzed. Most critical ill patients were older and had a greater number of comorbid conditions than patients with mild to moderate illness. This was consistent with a study [7] in which prospectively included 138 patients with COVID-19 and the researcher suggested that age and comorbidity may be risk factors for poor outcome. Moreover, our study showed that the ROC curve of age was administrated, and the best cut-off point of age was 52 years.
In accordance with Liu J's [12] and Wan S's [13] study, this study also found that the levels of lymphocyte count, neutrophil count and CRP were associated with the severity of COVID-19. In addition, ESR, PCT, D-dimer and SAA were also related to the disease severity. PCT levels in serum increase when severe bacterial, fungal and systemic inflammatory response syndrome occur, and it is generally not elevated with virus infections [14]. In our study, the PCT concentration in severe/critical patients was significantly higher than that in the mild/moderate group when PCT ≥ 0.04 ng/mL. It suggested the possibility of multiple infections in critically ill patients.
Besides, we also found that the levels of HDL-C and serum potassium were negatively correlated with the severity of COVID-19. According to Dong C's [15] study, hypokalemia was prevailing in patients with COVID-19, and the correction of hypokalemia was challenging because of continuous renal K+ loss resulting from the degradation of ACE2. HDL-C was known to play protective role in a variety of disease states, including viral pneumonia [16]. Serum HDL-C levels might decrease and serum total cholesterol/HDL-C ratios might increase proportionally in community-acquired pneumonia [17]. According to Wei C's [18] study, the spike protein of SARS-CoV-2 bound to HDL and antagonists of HDL receptor-Scavenger receptor class B type I inhibited SARS-CoV-2 infection. The lipids transfer function of Scavenger receptor class B type I was indispensable for this inhibition, providing explanations for the reduced serum HDL level in patients with COVID-19. In a retrospective study [19] reporting on 97 adults with laboratory-confirmed COVID-19, Decrease in HDL-C was found to be valuable in predicting the transition of COVID-19 from mild to severe illness. Similar results were obtained in our own research. Therefore, serum potassium and HDL-C levels may be a good prognostic index.
In this study, there were also some other abnormal indicators that had significant differences between the mild/moderate and the severe/critical group, such as plasma glucose, TBIL, AST, ALT, and LDH. These abnormalities suggested that SARS-CoV-2 infection may be associated with myocardia injury, hepatic injury and other related organ damage. Based on the ROC analysis between mild/moderate and severe/critical patients, some cut-off values of the test items were obtained. With age > 52 years, CRP > 64.79 mg/L, LDH > 245 U/L, D-dimer > 0.96 μg/mL, SAA > 100.02 mg/L, albumin < 36 g/L, progress to critical illness should be closely observed and prevented.
According to Lu J's study [5], a simple mortality risk index, composed of age and CRP, can predict COVID-19 related short-term mortality. In a retrospective cohort study [20] reporting on 191 adult inpatients with laboratory-confirmed COVID-19, multivariable regression showed increasing odds of in-hospital death associated with older age (odds ratio 1.10, 95% CI 1.03–1.17, per year increase; p = 0.0043) and D-dimer greater than 1 μg/mL (18.42, 2.64–128.55; p = 0.0033) on admission. According to Wu C's study [21], for the patients with COVID-19, risk factors associated with the development of ARDS and progression from ARDS to death included older age (hazard ratio [HR], 3.26; 95% CI 2.08–5.11; and HR, 6.17; 95% CI, 3.26–11.67, respectively), higher LDH (HR, 1.61; 95% CI, 1.44–1.79; and HR, 1.30; 95% CI, 1.11–1.52, respectively) and D-dimer (HR, 1.03; 95% CI, 1.01–1.04; and HR, 1.02; 95% CI, 1.01–1.04, respectively). So far, no study has shown plasma glucose, TBIL, AST and ALT were independent risk factors for COVID-19 progression. It is possible that these may be confounding factors, which still needs to be further confirmed.
According to the above, patients' conditions on admission including old age, comorbidities, lymphocytopenia, hypoalbuminemia, and other abnomal indicators may predict the severity of the disease. These factors need further investigation and should be considered for risk stratification. We have found that COVID-19 progressed rapidly for some critically ill patients. Therefore, for those at high risk, close monitoring and timely treatment might be very important and could help to improve the outcome.
This study has several limitations. First, it is a pity that some inflammatory factors and immunological indexes cannot be detected and compared due to the limitation of experimental conditions. Second, this is a cross-sectional study and participants were from 1 center rather than multiple centers. It provides no information regarding cause or effect relationship. Although we found significant associations, further studies are needed to investigate clinical significance of these indicators on patients with COVID-19.
With following parameters such as age > 52 years, C-reactive protein > 64.79 mg/L, lactate dehydrogenase > 245 U/L, D-dimer > 0.96 μg/mL, serum amyloid A > 100.02 mg/L, or albumin < 36 g/L, the progress of COVID-19 to critical stage should be closely observed and possibly prevented. Lymphocyte count, serum potassium, high-density lipoprotein cholesterol and procalcitonin may also be a prognostic indicator.
All data generated or analyzed during this study are included in this published article. The datasets used and/or analysed during the current study are available from the corresponding author on reasonable request.
SARS-CoV-2:
Severe acute respiratory syndrome coronavirus 2
ARDS:
ICU:
Erythrocyte sedimentation rate
CRP:
PCT:
Interquartile range
ROC:
Receiver–operating characteristic
HDL-C:
High-density lipoprotein cholesterol
LDL-C:
Low-density lipoprotein cholesterol
TBIL:
Total bilirubin
AST:
SAA:
Serum amyloid A
BUN:
Blood urea nitrogen
CK-MB:
Creatine kinase-muscle and brain type
APTT:
Activated partial thromboplastin time
Area under the ROC curve
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We thank Lianglong Peng for his reviewing and editing the diagrams and images.
Department of Neurology, Hubei NO.3 People's Hospital of Jianghan University, 26 Zhongshan Road, Qiaokou District, Wuhan, China
Dan Wang, Ruifang Li, Chang Gao, Juan Yang, Lintong Ge & Qing Hu
Department of Radiology, Tongji Hospital, Huazhong University of Science and Technology, Wuhan, China
Juan Wang
Department of Infectious Diseases, Zhongnan Hospital of Wuhan University, Wuhan, China
Qunqun Jiang
Ruifang Li
Chang Gao
Juan Yang
Lintong Ge
Qing Hu
WD was responsible for the conception and design of the study. WD, HQ and LG were responsible for acquisition and analysis of data; furthermore, WD, WJ and QJ were in charge of statistical analysis. WD and YJ took part in drafting the manuscript; GC and RL participated in the interpretation of the data and approved the final version of the manuscript. All authors read and approved the final manuscript.
Correspondence to Qing Hu.
This study was approved by the medical ethics committee of Hubei NO.3 People's Hospital of Jianghan University, and all participants provided informed verbal consent. The consent obtained was verbal because of the the infectivity and the exploration urgency for COVID-19. We obtained the verbal consent of the patient or his immediate family members by telephone and the ethics committee approved this procedure.
Wang, D., Li, R., Wang, J. et al. Correlation analysis between disease severity and clinical and biochemical characteristics of 143 cases of COVID-19 in Wuhan, China: a descriptive study. BMC Infect Dis 20, 519 (2020). https://doi.org/10.1186/s12879-020-05242-w
Received: 25 March 2020
DOI: https://doi.org/10.1186/s12879-020-05242-w
Prognostic indicator
Viral diseases


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Groundhog Day 2018: Other Animals That Actually Predict the Weather Better
Shove it, Phil.
By Sarah Sloat
Filed Under Biology, Flight, Sharks & Weather
There will either be six more weeks of winter or an early spring, depending on which groundhog you trust. The most famous groundhog, Pennsylvania's Punxsutawney Phil, and his comrade Potomac Phil of Washington, D.C. both saw their shadows Friday morning — which, by the law of Groundhog Day means it's going to be a long winter, baby. Meanwhile, Staten Island's Chuck and Long Island's Holtsville Hal didn't see their shadows, indicating that spring-like weather is just around this miserable corner.
This "will it be winter or spring" business is largely contingent on your willingness to get the weather report from some guys in top hats judging a large rodent. That's not scientifically advisable: Punxsutawney Phil usually doesn't get it right, and the National Oceanic and Atmospheric Administration says that groundhogs show "no predictive skill" for weather prediction. Actual human meteorologists, meanwhile, get it right about 80 percent of the time.
Nevertheless, humans still booed Phil this morning when winter was announced because we are monsters.
JUST IN: #GroundhogDay: Punxsutawney Phil has seen his shadow, declaring 6 more weeks of winter during annual Feb. 2 tradition in Punxsutawney, Penn. pic.twitter.com/729IVk2lR2
— NBC News (@NBCNews) February 2, 2018
But just because we can't rely on groundhogs to give us precise weather forecasts doesn't mean animals have zero predictive abilities. Groundhogs may unfairly get all the attention, but here are some critters who actually have a sense of what weather is to come.
Gold-winged warblers can predict severe weather.
It's no secret bird flight is affected by the weather: Fierce storms can blow birds off course, and low air pressure makes it difficult for birds to fly. To survive, birds are thought to have evolved to have some predictive power when it comes to bad weather. A 2013 study from Western University's Advanced Facility for Avian Research discovered that birds can predict weather changes by tracking the rise and fall of barometric pressure. Birds, the researchers explain, have their own internal barometers, and they typically choose not to fly when placed into conditions with high air pressure, understanding there's a high chance they'll encounter a storm.
In 2014, scientists discovered birds can detect severe weather in another way: They can detect the infrasound — sound waves lower than what humans can hear — of storms. In a paper published in Cell, scientists explain that golden-winged warblers, migratory birds native to North America, can pick up the low-frequency sounds, allowing them to detect storms up to 600 miles away. This ability is believed to be shared by many birds: In a 2013 study in the Journal of Experimental Biology scientists discovered that pigeons can detect infrasounds too.
True armyworm moths can detect drops in atmospheric pressure.
At least some insects can predict the weather, especially when they're trying to mate. In a paper published in PLOS One in 2013, an international team of scientists reported that curcurbit beetles, armyworm moths, and potato aphids all decided to forgo sex when the scientists lowered the atmospheric pressure in their enclosure. Female bugs stopped wafting their sex hormones toward the males, and male bugs just stopped paying attention to the females.
This disinterest in sex, the scientists believe, occurs because insects know that a drop atmospheric pressure means a rainstorm is probably coming. Rain really ruins the mood when you're a little bug; you don't want to be washed away while you're out trying to do the deed. Scientists aren't sure how the insects detect atmospheric changes but think it may come down to the hair-like receptors on their cuticle.
Sharks sense oncoming storms.
Sharks are also sensitive to barometric pressure, which drops when a storm blows in. When they feel this drop in the ocean, they swim into deeper waters, where it's safer. This is good news for other fish, who often note sharks' dive to the depths as an indication that they need to swim to a safer spot as well.
When tropical storms begin to form, scientists have observed sharks migrating toward the layer of water known as the isotherm. This layer of water is 26 degrees Celsius, which is also the minimum temperature required for a storm to form. Again, scientists aren't sure how exactly sharks know to move to this layer, but they're currently studying shark behavior so we can steal their technology to predict hurricanes.
Media via Twitter, Caleb Putnam/Flickr, Wikimedia Commons (1, 2, 3), Giphy
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Alejandro Fernández conquers the mountains during his holidays in the snow
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Arturo Vidal's new nod to America
Alejandro Zendejas and his arrival in America: "He feels great" | Sports League MX
Home/Sports/Sandber Pimentel is admonished for receiving money from a fan after hitting a home run
Sandber Pimentel is admonished for receiving money from a fan after hitting a home run
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Santo Domingo, RD.
Dominican outfielder Sandber Pimentel was reprimanded by the Professional Baseball League for receiving money from a fan after hitting a home run last Sunday that gave his team, the Estrellas Orientales, victory over the Gigantes del Cibao.
Pimentel was sent to pinch hit at the end of the ninth inning at the Tetelo Vargas stadium in San Pedro de Macorís (east), home of the Stars, when the clash was lost by his team 3-4.
Pimentel dispatched the homer that allowed the locals to come back and win 4-6.
As Pimentel celebrated his victory with his teammates, a fan standing in the lower boxes called him and then gave him 20,000 pesos (about $ 348) for hitting the winning ball.
The president of the Dominican Professional Baseball League (Lidom), Vitelio Mejía, admonished the player for receiving the money.
The fan had bet 100,000 pesos (about $ 1,740) that the Stars would win the game in that same inning, even though they were at a disadvantage.
The moment the bettor gave the money to Pimentel was recorded, the video went viral and caused the reaction of the league.
"Mejía contacted the player, who is very sorry for what he did, and promised that he would return the money to whoever gave it to him. In addition, the president of Lidom had conversations with the Dominican Federation of Professional Baseball Players and with the management of the Eastern Stars, "a source from the League told Efe, who requested that his identity be reserved.
The Stars and the Giants, together with the Tigres del Licey and the Águilas Cibaeñas, league champions, compete in the semifinals of the tournament.
The finalists, in addition to fighting for the title, represent the country in the Caribbean Series to be held in Santo Domingo.
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Elizabeth Moleyns (born 1563) was an English courtier.

She was the daughter of Sir Thomas Southwell (d. 1568) of Woodrising, Norfolk and his third wife Nazareth Newton. She was a half-sister of Vice Admiral Robert Southwell.

Elizabeth Southwell was a Maid of Honour to Queen Elizabeth.

There may be some confusion among ladies in waiting to Elizabeth and Anne of Denmark called "Mistress Southwell", including her niece Elizabeth Southwell who ran away from court and married Robert Dudley. This Mistress Southwell came to court in January 1600, as a replacement for Margaret Radclyffe, and Rowland Whyte noted she would be sworn in as a maid of honour, "My Lady Newton having sought it for her daughter". (Nazareth Newton was her aunt, not her mother). Elizabeth Dudley's mother was another "Mistress Southwell" at court, Elizabeth Howard, Countess of Carrick, the widow of Elizabeth Moleyns' brother Sir Robert Southwell.

Southwell was a mistress of Robert Devereux, 2nd Earl of Essex and in 1591 mother of Walter Devereux. Her pregnancy and absence from court was disguised as a "lameness in her leg". For a while Thomas Vavasour pretended to be the father, to protect the reputation of the queen's favourite, but Queen Elizabeth discovered the facts in May 1595.

She married Sir Barentine Moleyns of Clapcot near Wallingford in 1599. Moleyns, who was younger than his wife, was said to be notorious for his ugliness and was a veteran soldier weakened by his injuries.

Rowland Whyte mentioned that "Lady Moleyns, she that was Mistress Southwell, the maid" came to the christening of Barbara Sidney, daughter of Sir Robert Sidney and Barbara Gamage, in December 1599 in the company of Anne St John, Lady Effingham.

She had a son, Michael Molyns.

References

British maids of honour
16th-century English women
1563 births
Elizabeth

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miicah replied to Spackbace on [AMA] I Am a Car Salesman, Ask Me Anything!
So what about if you get finance and then just put your cash on the loan straight away?
miicah replied to serpserpserp on Does Chiropractic Work?
I was 15 and he came recommended.
miicah commented on Will Lenovo Yoga 920 SSD Fit in Lenovo Yoga 910?
Is that bracket rated for a car though?
I hate when people don't utilise the two lanes on a roundabout. This is just an extension of that.
miicah replied to Bimo on Does Chiropractic Work?
Try pihole if you want device wide adblocking on your home network.
Because you wouldn't trust any data that isn't instantly replaceable on a drive like this.
You expect the owner to know every minimum thickness specification for every vehicle just off the top of his head?
miicah replied to Scrooge McDuck on How is the transition to EVs going to reconcile the fact that most don't have a garage to charge in?
I've heard that all the electrons are actually the same when they come into port, just each company uses different additives.
Is this possibly a catalogue deal or a new line that wasn't supposed to be put up on the website yet?
I grabbed a cola one!
The Kobo Clara is $159, which is cheaper than the $161 for the waterproof Kindle on the Good Guys store. Which one to get?
miicah replied to wannagrababargain on Assuming a Partner's Credit Card Debt...via Balance Transfer?
miicah commented on How Do You Go with Trusting Mechanics?
I think $300 is suspiciously cheap for a head gasket repair.
Ugh I waited all day yesterday for a 10% Cyber Monday deal and now wake up to this!? Fark!
My card is linked to google pay, should I still be able to use it?
Will this work on my android phone/tablet?
Grab the Nexgard if you use it. I bought the 6month supply for $76 (+5% gift card) down from $133!
They seemed to have fixed this, had the same problem last night and was just able to put my C+C order through.
PCI-E card? Or do you have a laptop?
I think I'd rather have an official one.


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Judson L Moore
Author and Travel Addict
WhileYoung
Deliver user value
Present your best self
Learn everyday
Grow professionally
The toughest job
By and for women
Plan for the worst
About Judson
Moving To Bishkek - New City. New Work. New Address.
I am moving To Bishkek, Kyrgyzstan to continue to the next step of my Peace Corps Service. Get all of my new details and learn about my new project here.
September 17, 2012 Posted by Judson L Moore
I Am Moving To Bishkek
I've have had a very busy and productive summer full of summer camps, exploration and moving to the capital city. I moved to Bishkek in August to expand my work developing the independent broadcast media of Kyrgyzstan. (Please update your records with my new address available on this PDF Mailing Label).
Previously, while working in Talas, I was working at RadioMost 100.5 FM, the premier community radio station of Kyrgyzstan, where I was assisting them to develop new radio stations across all regions of the country. Now I have moved to Bishkek to work with the Kloop Media Foundation to develop the first ever internet radio broadcast originating from Kyrgyzstan. This station's format will be similar to NPR or the BBC in that it will be mostly news but will also feature special stories originating from corespondents, or in our case the programs will largely originate from the community radio stations with which I have worked for the past year.
The New Project: kyrgyzmedia.kg
This project aims to expand the reach of the small radio stations in the rural areas of the country and allow for the whole world to tune in 24/7 and listen to radio journalists reporting from all regions of the country. Kloop currently produces a daily 30-minute news program in 3 languages (Russian, Kyrgyz and Uzbek) which can be heard at https://radio.kloop.kg. Analytics of the Kloop website suggest that our main audience are Kyrgyz immigrant workers living abroad, primarily in Russia. By providing streaming radio, these Kyrgyz people living abroad will have a chance to hear not only the national and headline news of Kyrgyzstan, but hear what is happening in their home communities.
The internet broadcast is scheduled to begin in January 2013. I will keep you updated on our progress.
My Ask Of You
In the meantime, please consider sending me a care package (I'm out of peanut butter!) and check out these photos of my new city:
The White House is the presidential work place of the Kyrgyz Republic. This is about 1 block from my apartment. Ala Too Color Guard The National Philharmonic was the site of my swearing-in ceremony to the Peace Corps and is about 2 blocks from my apartment. Lenin stands strong facing the parliament building of the Kyrgyz Republic. His back is to the National History Museum, which used to be the Lenin Museum.
bishkek kloop kyrgyzstan peace corps site change
Travel addict. Ambitious about making the world a better place. Writing what I learn along the way.
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© 2021 Judson L Moore


Marketing Sherpa's famed Marketing Wisdom Report is now available and can be downloaded for free. For now. Dawdle and you'll end up paying $127.
I love this annual publication. It's a beautifully simple, attention-getting service on Marketing Sherpa's part. They simply solicit marketing stories from their readers (so you practical, down-to-earth guidance, not pie-in-the-sky theorizing) and weave it into a report.
This years wisdom comprises 101 real-life stories and lessons learned. Mostly for-profit companies but all of their stories are relevant to you (and Network for Good is there too). Jump on it.
PS I'm just diving into my copy and will blog on most useful findings.


KRG Children's Charitable Foundation (KRG CCF)has generously provided a donation of $10,000 for Speroway's First Nations Children's day camp in Mishkeegogamang, ON.
The Mail Has Stopped: Donations Are Down!
On June 14, 2011 Canada Post was forced to shut down urban operations nationwide.
Following 12 days of rotating strikes by the Canadian Union of Postal Workers (CUPW), Canada Post suspended operations across the country.
As an International charitable organization we are currently responding to the rotating postal strike.
Article from insideHalton featuring Iris Renderos and team from Towne Dental in Milton, ON.
Dr. Steve Russell is in El Salvador now with an FTC Canada Medical-Dental team providing primary medical care to desperately needy families in and around the capital city of San Salvador.
The Scugog Standard reporter Blake Wolfe speaks with the two local Port Perry doctors in this article, following their medical relief trip to Haiti.
Chris Hall, a writer for durhamregion.com speaks with Dr. Anthony Brown (FTC Canada Medical Advisor) about his recent experience in Haiti.
The Hamilton Spectator talked with paramedics that returned from the "war zone" of Haiti. The paramedics were from Halton and one was from Brampton.
The story recounts the conditions on the ground and the heartwrenching work that had to be done just to save lives.
A letter to the editor posted at the newsdurhamregion.com website (Jan 25, 2010) extends a word of thanks to the medical personnel that made the trip to Haiti.
Updated Jan 26, 2010 There is a public facebook page for the Halton Paramedics in Haiti. Be sure to check it out as there are about 70 photos to look through including shots of the team and the city of Port-au-Prince.
FTC Canada has put out a request to the trucking industry in their mission to provide food and medication to Haiti.
FTC relies on the trucking industry to move food all over Canada but the challenge here is very specific.
Updated Jan 20, 2010In a whirlwind of activity including phone calls to the Canadian International Development Agency (CIDA) FTC Canada has been able to assemble a team of doctors and paramedics and secure a flight to Haiti.
The team will include 11 paramedics, mostly from Halton region and 3 doctors.


L to R: Prime Minister Leona Romeo Marlin & Minister of State for Curacao Jaime Saleh.
SINT MAARTEN (POND ISLAND) – Recently, while attending a meeting on Sint Maarten, Jaime Saleh in his current capacity as Minister of State for Curacao and board member of the Dutch Caribbean Nature Alliance paid a brief courtesy visit to Prime Minister Leona Romeo Marlin at the Government Building.
Mr. Saleh and Prime Minister Romeo Marlin discussed the ongoing recovery process and the current state of affairs on Sint Maarten.


Id like to know if there is amining pool that allow us to mine Bitcoins, Namecoins and Litecoins at the same time.
I kow there is some that allow us to mine Bitcoins and Litecoins but I couldnt find one to mine those three.
Bitcoins and Namecoins can be mined at the same time, because the underlying algorithm is the same. But you can not mine Litecoin and Bitcoin at the same time without the loss of hashes/sec, because it uses different crypto algorithms. Therefore I highly doubt that there is something like you have claimed in your question.
As mentioned before, the loss in hashes means that bitcoins can't be mined efficiently on the same hardware as litecoins.
I've been using http://cex.io/ which mines a number of other coins at the same time, such as namecoin and devcoin. It's backbone is ghash.io, which is the largest mining pool out there.
Depending on how much gigahashes you buy, you could see a return pretty quick. I pondered investing in hardware, but it seems somewhat expensive now.
Not the answer you're looking for? Browse other questions tagged litecoin namecoin or ask your own question.
Is there any evidence that the Litecoin network is significantly affected by botnet mining?
How can I create and setup an litcoin mining pool?


Blooms of Spring – The Flower Room, Dover NH Florist – Same Day Flower Delivery in Dover NH and surrounding area.
Purples and greens and all the best flowers of springtime. Hydrangea, veronica, roses and more in this modern interpretation of a garden-style arrangement.


Dream Design Build & Remodeling, Inc is a well-respected firm in the Baltimore, Maryland area. The company is an architectural design company which is ready to help you, our clients, bring your dream home visions to life. We can take care of the entire process in a professional manner. We are the remodeling contractor in Elkridge MD who can plan, design and build new homes, or remodel existing homes.
The superior skills of our highly trained and experienced architects, interior designers, and contractors will be manifested in the completed project. Are you looking for a renovation contractor in Ellicott City? If so, we are a reliable full-service firm that is ready to help with your planning, design, and implementation.
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"CWW has given me many good friends as well as letting me share many new experiences."
"Through CWW my wife and I have met and become good friends of many people we otherwise would not have encountered during our many years as residents of Princeton. And, it has been fun to share interests with them through groups engaged in writing reminiscences, exploring gardens, ethnic dining, and movie going. Also valuable have been programs and activities that help us age at home."


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I chose to go to La Casa Del Rey for the first time about a week ago because I met one of the owner's family members and I liked the story he told me: a quarter century in existence growing from a dream to a small four-table operation to a busy and successful Commerce City standard. All the while run by the same family from our own San Luis Valley, literally going back almost 100 years to take pages from grandma's old recipe book. Oh, and I am always up for something new and I have to admit that I have never once been to a restaurant in Commerce City. Or for that matter written the words: "Commerce City Standard".
CC (not to be confused with the Chocolate City-- which would be hard) is thought of by most Denverites as a commercial and industrial wasteland, and not without reason; but at the same time it is full of working-class families and pockets of communities that are the basis for forming good neighborhood restaurants. I was hoping La Casa Del Rey would be one of them.
There are mixed signs to be found when one is considering eating his first meal at the House of the King. Consider the withered banana (pepper I suppose) that appears to be coming off a sleepless three-day bender and thought that by putting on a ton of make-up she would be able to show up at work and no one would notice. Little did she know that was the day La Casa decided to take her picture and emblazen it on eveything from the website, the servers, the menus and even t-shirts for little babies. Mrs. Cha Cha, as she is known, reminds me of an old lady who spent one too many years sunning by the pool in Florida. And trust me, you don't want this picture on your chest. Or your menu.
On the other hand, the fact that La Casa embraces this pepper so much makes it somehow funny and OK. And they keep with the preferred way of spelling "chile" which I take as a tremendously great sign. Plus the rest of the back story of this restaurant as it was told to me included the fact that just about everything at La Casa Del Rey is made from scratch in-house: from the beans and tortilla chips to the shredded beef and chile rellenos. And again, many of these are good old-fashioned Southern Colorado recipes. This is about as Colorado as it gets.
And this is why, as promised in my last post, I was bringing my Mexican in-laws out to dinner at a Mexican restaurant. But of course this is not a Mexican restaurant in a pure sense, and as I have dedicated many lines of prose to the differences between Mexican food and New Mexican-- or food from Southern Colorado (remember it was all Mexico about 150 years ago)-- I won't bore you again on the differences. Suffice to say I was bringing my in-laws here to taste the distinct flavors of Coloradan fare that developed just like another region of Mexico-- though with the technicality that it was now in the US.
La Casa Del Rey is an adobe structure just off Quebec on 72nd in the heart of Commerce City. Inside it is wildly decorated with tropical faux palm-leaf ceiling fans, wooden parrots, southwestern prints and utilitarian booths and tables. None of these are particularly good signs for me either, and I doubted myself for a second for bringing my in-laws here for their first true Southwestern food experience.
We sat down while being serenaded by the sounds of a guitar duo. This was a nice touch, and they quickly warmed to my family and even belted out some obscure requests form my mother in-law while we sipped our drinks. I also immediately ordered us a big plate of green chile, and for the first time my inlaws brought a spoonful of green chile to their mouths.
I have to say that it was a very good green chile, cooked the way I like it with big chunks of red tomatoes and chiles, just a little thick but mostly soupy, just the right amount of spice in the hot version and all with a casera (homemade) taste and comfort. We all liked it very much and I breathed a sigh of relief that my inlaw's first green chile was this good.
While we savored our green chile, we browsed the extensive menu and I decided on the enchiladas with shredded beef--smothered, of course, in green chile. The house-prepared, hand-shredded beef was indeed moist and rich with flavor. Topped with the green chile and mixed in with the thick refried beans, it was an excellent plate of enchiladas.
My wife ordered the chiles rellenos, which quickly became the talk of our table. Unlike its Mexican counterpart, traditional chiles rellenos in these parts are made with the long New Mexican green chile instead of the shorter and stouter Mexican poblano. I don't know if my mother-in-law ever quite believed that her daughter was eating chiles rellenos, but she did agree that, whatever it was, it was really good. The batter was thick and fried crisp, the chile fresh and the cheese melted in with the smothered green chile sauce.
My father-in-law had an excellent plate of Steak Ranchero: sliced strips of steak covered in a sweet and spicy tomato and chile sauce. It reminded him of Puntas de Res a la Mexicana, which is another, very similar dish of beef tips covered in a red sauce all mixed in with sauteed peppers and onions. Whatever it was, there was an enormous plate of it and we all got to try a healthy share of it.
My mother and sister-in-law had relatively unremarkable plates of carne asada and a carne asada burrito, respectively. Although, to be fair, my sister-in-law ordered her burrito without the green chile, which is a lot like getting a slice of pizza without cheese or sauce, but being fifteen, she is a little less-than-adventurous and in the end really did like her meal. Here is what her burrito contents looked like on a small tortilla (flour of course) with a nice helping of green chile and beans. Now that was good.
We finished it off with a round of sopapillas. Just like the chile relleno plate, my family gave me a confused look when a plate of five fluffy pieces of plain-looking dough came out for our dessert. For some reason I am not a huge fan of the sopapilla, although I do recognize that fried dough drizzled in honey is generally a good thing. These were good sopapillas, and got the nod of approval from the in-laws by being devoured in a matter of minutes.
Regardless of what the signs were for La Casa Del Rey, in the end it was a great meal with friendly service and fun entertainment. While the kitschy and dated interior decor reflects the 25 years this restaurant has been up and running, the food reflects a family that still cares about its patrons by turning out quality plates served by a friendly and efficient staff. Yes, La Casa del Rey is exactly the type of neighborhood restaurant that I hoped to find in CC, and is a comforting taste of Grandma's home-style Southern Colorado cooking perfected after generations of practice.
What do Joe Biden, Dog the Bounty Hunter and a young John Elway all have in common? They all have been to La Casa de Rey over the years and had their mugs added to the walls and website of La Casa. See if you too can join this elite crowd by visiting La Casa in our industrious neighbor to the north and eating a plate of their excellent green chile.


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The Four Layers of Smart City Architecture, and How They Can be Implemented
There's no question that technology has infiltrated every corner of our lives, from smartphones and watches to smart doorbells, electric cars, and non-stop streaming media. And most would agree that technology makes us smarter. Or at least more aware and engaged. Cities worldwide, too, have gotten smarter. As a matter of fact, smart cities are [...]
By Lyle Hauser|2021-12-21T20:28:12+00:00November 25th, 2021|Blog|
With 5G Still in Development, A Glimpse Ahead at 6G
5G technology has brought the world its fastest generation of wireless technology ever. Tech savants will tell you that includes greater speed, ultra-low latency, more reliability, grander network capacity and a better user experience. Experts believe, in fact, that the 5G rollout, when it is complete, will unleash "the Internet of Everything," which has been [...]
Balancing Short- and Long-Term Goals in IoT Deployment
While there is considerable hype surrounding autonomous vehicles, there are still miles to go before widespread deployment of this technology. A 2020 MIT study concluded, in fact, that Level 4 implementation -- i.e., the appearance of self-driving vehicles that can handle complex situations, albeit with human monitoring -- will likely not be seen until at [...]
By Lyle Hauser|2021-09-23T19:05:15+00:00August 15th, 2021|Blog|
The Future of AI, According to Business Leaders
Momentum continues to gather within the business world around artificial intelligence, described by one leader as "the glue that stitches analytics results with actions" and another as a technological breakthrough that is essential for success. Still another leader surveyed the AI landscape and offered this assessment: "The future is indeed AI for everyone." The present, [...]
By Lyle Hauser|2021-09-23T19:05:51+00:00August 8th, 2021|Blog|
Can You Hear Us Now? Where 5G is Concerned in the U.S., That's Still Not Clear
In November 2020 T-Mobile executive Neville Ray declared to Fortune magazine that where 5G was concerned, his company was "off to the races" and that it "came out of the blocks super quick." T-Mobile, labeled in that same Fortune piece as "the next big thing" by Craig Moffett of MoffettNathanson Research, has been able to [...]
By Lyle Hauser|2021-06-28T18:13:03+00:00June 21st, 2021|Blog|
The IOT Cybersecurity Act: What it Could Mean Going Forward
Leading up to the Presidential inauguration of Joe Biden, his Peloton had become a matter of national security. Equipped with a camera and a microphone, the President's stationary bike has been considered a prime target for hackers, which led to a debate as to whether he should even bring it into the White House. Now, [...]
By Lyle Hauser|2021-04-28T15:37:52+00:00February 6th, 2021|Blog|
Tech in 2021: Get Ready for the Internet of Behavior
The coronavirus pandemic has changed the business landscape, and as we head into 2021 its impact will continue to be felt. While remote work has become a necessity at many businesses (something that promises to be the case, well into the new year), there are those enterprises where that is not possible -- where employees [...]
By Lyle Hauser|2021-12-21T20:26:20+00:00February 2nd, 2021|Blog|


text:
Q: Can I change the title of my FolderBrowserDialog? I'm curious and it could give my little app a nice finishing touch. Thanks!

A: You can't if you use the class FolderBrowserDialog directly. But I read somewhere that it could be possible to change the title with P/Invoke and sending WM_SETTEXT message.
In my opinion, it is not worth the pain. Just use the property Description to add the information:
FolderBrowserDialog dlg = new FolderBrowserDialog();
dlg.Description = "Select the document folder";

A: The simple answer is that you can't. The dialog displays using the standard title for a folder browser style dialog on Windows. The best option is to ensure that you have meaningful descriptive text by setting the Description property.
Even if you were to use P/Invoke to call the SHBrowseForFolder Win32 API function directly, the only option you still can't change the actual title of the dialog. You can set the lpszTitle field of the BROWSEINFO structure, which is

A pointer to a null-terminated string
  that is displayed above the tree view
  control in the dialog box. This string
  can be used to specify instructions to
  the user.

A: You can change it by using:
SetWindowText (hwnd, "Select a Folder");

Where hwnd is the window handle, which triggers the Browse For Folder Dialog.

A: I was looking up how to do this, but largely had to figure it out on my own.
I hope this saves anyone some time:
Above my main method, I put:
    [DllImport("user32.dll", EntryPoint = "SetWindowText", CharSet = CharSet.Ansi)]
    public static extern bool SetWindowText(IntPtr hWnd, String strNewWindowName);
    [DllImport("user32.dll", EntryPoint = "FindWindow", CharSet = CharSet.Ansi)]
    public static extern IntPtr FindWindow(string className, string windowName);

Since I know that the thread will pause while the dialog is shown, I created a new thread to check for that dialog window while it exists.  Like so:
    bool notfound = true;
    new Thread(() => {
    while (notfound)
    {
        //looks for a window with the title: "Browse For Folder"
        IntPtr ptr = FindWindow(null, "Browse For Folder");
        if (ptr != IntPtr.Zero)
        {
            //tells the while loop to stop checking
            notfound = false;
            //changes the title
            SetWindowText(ptr, "Be happy!");
        }
    }
    }).Start();

Then, I initiate the dialog:
    using (var fbd = new FolderBrowserDialog())
    {
        DialogResult result = fbd.ShowDialog();
        if (result == DialogResult.OK && !string.IsNullOrWhiteSpace(fbd.SelectedPath))
        {
            //do stuff
        }
    }

This has worked for me, and it's not so complicated.  Hope this helps anyone that might stumble on this page.
By the way, remember that the thread must start before the dialog window is initiated, so that it can run and check for the window as soon as it exists.

redpajama_set_name: RedPajamaStackExchange


text:
RL Leaders Come Together to Share Best Practice
Words: Jeremy Monahan
Fri 20 Feb 2015, 09:23 AM
A ground-breaking forum which brought together NRL and Super League club representatives to share best practice has been hailed as a major success for the sport.
The forum featured keynote presentations from senior figures involved in both competitions, including the Chief Executives of respective champions South Sydney Rabbitohs and St Helens, Shane Richardson and Mike Rush.
The event took place today at MediaCityUK in Salford ahead of this weekend's World Club Series and Super League General Manager Blake Solly believes it will bring the two competitions closer together.
"The Best Practice Forum was a very rewarding and informative initiative which further cemented the healthy relationship that exists between Super League and the NRL," said Solly.
"It was a hugely successful venture and is certainly one we will be looking to repeat in the future.
"The presentations showed what an exciting journey the sport is on, both here and Down Under. We face similar challenges and opportunities and are both working hard to maximise the success of a sport that is experiencing a fantastic period of growth.
"It's clear that Rugby League has a great future on both sides of the world."
Shane Richardson, who has lead clubs in both Australia and the UK throughout his club career, delivered an engaging presentation on the membership scheme that has helped transform the fortunes of South Sydney Rabbitohs. Richardson explained how the club had grown from having 18,500 members in 2010 to 31,000 Members to date with a goal of 35,000 in 2015 and outlined the benefits that forging closer links with supporters had brought. This included the Club's efforts to engage with its Members on a 'Members First' basis as often as possible, and listening to their valuable feedback to provide Members with what they want from their Football Club.
Stand Above the Rest in 2015 and become a Rabbitohs Member Now!
Paul White, the Chief Executive of Brisbane Broncos and a former Hunslet player, explained the Queensland club's sponsorship strategy and Peter Doust, the long-serving Chief Executive of St George Illawarra, detailed how the Dragons worked to maximise fan engagement through digital and social media.
From Super League, Wigan Warriors Marketing Director Simon Collinson delivered a presentation on the success of the club's 'Big One' concept which had produced significant attendance growth whilst Neil Kelly from the Warrington Wolves Foundation spoke of the sterling work undertaken in the fields of social welfare, health, education and young people.
St Helens Chief Executive Mike Rush chronicled the way in which he had transformed the culture within a club which is now profitable after years of financial losses, despite being one of the most successful clubs of the Super League era on the pitch.
The event concluded with a presentation from Andrew Hill, the NRL's General Manager League Integration and Development, who spoke of the governing body's ambitions to maintain profitability, invest for the future, enhance player welfare and continue the growth that has seen the NRL become Australia's largest sporting competition.
This historic weekend of Rugby League concludes with the 2015 World Club Challenge, St Helens vs South Sydney Rabbitohs, at a sold-out Langtree Park in St Helens on Sunday at 7pm (Monday 6am AEDST).


text:
Geekery Saturday – September 30
2 years ago sjferrari
Another week of news has come and gone. As we close out September, let's take a look at what's happened over the last few days.
• Hot on the heels of the SNES Classic's release to scalpers yesterday comes news that we'll be getting another retro system next year, but this time Nintendo has nothing to do with it. The C64 mini – a new system based on the classic Commodore 64 system – will feature 64 games and a classic style joystick. The system's website has 37 games listed right now, with more to come.
• Long-time Dark Horse editor Scott Allie has stepped down from the company to become a freelancer, according to a report on rumor site Bleeding Cool. The editor, who started in 1994 editing Hellboy, was responsible for shepherding Joss Whedon's extended Buffy comics through the company and served as editor-in-chief from 2012-2015. He stepped down to the title of executive senior editor after allegations of sexual misconduct came to light.
• Billy Zane, best known for being Billy Zane in Titanic and The Phantom, will do it one more time, this time at legendary huckster PT Barnum on DC's Legends of Tomorrow. If anyone would take advantage of weird anachronisms running around the world. it would be PT Barnum.
As an aside, for an hysterical refresher on Barnum's life, take a listen to episode 291 of THE DOLLOP podcast, where comedians Dave Anthony and Gareth Reynolds discuss all the crazy things the man did. Definitely worth a listen.
• Finally, Lynda Carter, who played Wonder Woman in the 1970s TV show, has decided to weigh in on James Cameron's opinions about whether the movie WONDER WOMAN was "groundbreaking" or if it was a step back for female characters on the big screen. Yesterday, she posted this to her Facebook page:
To James Cameron -STOP dissing WW: You poor soul. Perhaps you do not understand the character. I most certainly do. Like all women–we are more than the sum of our parts. Your thuggish jabs at a brilliant director, Patty Jenkins, are ill advised. This movie was spot on. Gal Gadot was great. I know, Mr. Cameron–because I have embodied this character for more than 40 years. So–STOP IT.
What will you be talking about today?
Tags: Billy Zane, Commodore 64, Dark Horse, Legends of Tomorrow, Lynda Carter, PT Barnum, The Dollop, Wonder Woman
Previous Geekery Release Friday – September 29
Next Sunday Catch-Up – October 1


Obviously, when you have bad symptoms, you need to do what you have to do and take the medicine. how often is taking an abx like Bactrim too often. Capsules are slow dissolving hence it might take some time for the pet to show palpable signs of improvement. When it comes to oral antibiotics such as amoxicillin, every 6 hours should be.If the prescription says 3 times a day (tid), every 8 hours is not the requirement.
Amoxicillin works well against many of the bacteria that cause sinus and ear infections,.
Amoxicillin is generally thought to be safe in puppies and senior dogs but is not for pregnant or nursing dogs because amoxicillin can cause defects in the smallest.WebMD experts and contributors provide answers to: can you take amoxicillin for a uti.
Amoxicillin Efficacy for Strep Throat. it should be treated with penicillin or amoxicillin.Bought in mexico can be used for a water infection amoxicillin refrigeration life how often do you take amoxicillin 500 mg much can give my cat. 2 grams is how many.Outdoor feline explorers are often more prone to catching illnesses as they.
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Amoxicillin is often used in preference to penicillin V in children.How should I take amoxicillin and clavulanate potassium (Augmentin).
How Often Do You Take Amoxicillin For Sinus Infection amoxicillin 500 mg tabletta amoxicillin antibiotic tablets side effects how often do you take amoxicillin for.These drugs are often used to treat similar conditions. If you need to take amoxicillin, your doctor may prescribe a different form of birth control for you.
You are right that taking antibiotics too often can be a bad.
Amoxicillin is a commonly used antibiotic drug in the penicillin group that fights bacteria and bacterial.
Guides through decision to take antibiotics for acute bronchitis. Can you take antibiotics as often as you feel you need to and still have them work every time.
Ingredients for injection package insert cost of flonase generic how often to take 500 mg.
How many times a year can you take antibiotics without having to worry too much about.Read more about the prescription drug AMOXICILLIN TABLET 875 MG - ORAL.
However, resistance to these drugs does occur when they are used too often.


text:
var express = require('express');
var router = express.Router();//Generamos enrutador

var multer = require('multer');
var upload = multer({ dest: './uploads/'});

//Importamos los controladores
var quizController = require('../controllers/quiz_controller');
var commentController = require('../controllers/comment_controller');
var userController = require('../controllers/user_controller');
var sessionController = require('../controllers/session_controller');

/* GET home page. */
router.get('/', function(req, res) {//Metemos el get al pth vacio, raiz.
  res.render('index', { title: 'Cambiando titulos' });
});

//Aoutoload de parametros
//Si existe parámetro quizId en la ruta, entonces invoca
//quizController.load ( ejecuta funcion autoload y queda cargada)
router.param('quizId', quizController.load); //autoload :quizId
router.param('userId', userController.load); //autoload :userId
router.param('commentId', commentController.load); //autoload :commentId
//Se instala para que se ejecute antes que lo necesiten
//las rutas show y answer y solo en caso de que path contenga :id

//Definición de rutas de sesión
router.get('/session',    sessionController.new);     // formulario login
router.post('/session',   sessionController.create);  // crear sesión
router.delete('/session', sessionController.destroy); // destruir sesión

//Definición de rutas de cuenta
router.get('/users', userController.index); //listado usuarios
router.get('/users/:userId(\\d+)', userController.show); //ver un usuario
router.get('/users/new', userController.new); //formulario sign up
router.post('/users', userController.create); //registrar usuario
router.get('/users/:userId(\\d+)/edit', sessionController.loginRequired,
                                        sessionController.adminOrMyselfRequired, userController.edit); //editar cuenta
router.put('/users/:userId(\\d+)', sessionController.loginRequired,
                                    sessionController.adminOrMyselfRequired, userController.update); //actualizar cuenta
router.delete('/users/:userId(\\d+)', sessionController.loginRequired,
                                      sessionController.adminAndNotMyselfRequired, userController.destroy); //borrar cuenta

//Definicion de rutas de /quizzes
router.get('/quizzes.:format?', quizController.index);
router.get('/quizzes/:quizId(\\d+).:format?', quizController.show);
router.get('/quizzes/:quizId(\\d+)/check', quizController.check);
router.get('/quizzes/new', sessionController.loginRequired, quizController.new);
router.post('/quizzes', sessionController.loginRequired,
                        upload.single('image'),
                        quizController.create);
router.get('/search', quizController.search);
router.get('/quizzes/:quizId(\\d+)/edit', sessionController.loginRequired,
                                          quizController.ownershipRequired, quizController.edit);
router.put('/quizzes/:quizId(\\d+)', sessionController.loginRequired,
                                      upload.single('image'),
                                      quizController.ownershipRequired, quizController.update);
router.delete('/quizzes/:quizId(\\d+)', sessionController.loginRequired,
                                        quizController.ownershipRequired, quizController.destroy);
router.get('/author', quizController.autor);

router.get('/quizzes/:quizId(\\d+)/comments/new', sessionController.loginRequired, commentController.new);
router.post('/quizzes/:quizId(\\d+)/comments', sessionController.loginRequired, commentController.create);
router.put('/quizzes/:quizId(\\d+)/comments/:commentId(\\d+)/accept', sessionController.loginRequired,
                                                                      quizController.ownershipRequired,
                                                                    commentController.accept);

module.exports = router;

redpajama_set_name: RedPajamaGithub


(CNN) - Australia relaxed rules about shooting kangaroos in New South Wales (NSW) Wednesday as the state was declared "100% in drought" after months of little or no rain.
Less than 10 millimeters of rain fell in the state in July, the fifth-driest on record, putting further pressure on dwindling food supplies for cattle that can no longer graze on parched land.
"This is tough, there isn't a person in the state that isn't hoping to see some rain for our farmers and regional communities," Primary Industries Minister Niall Blair said in a statement.
Large numbers of kangaroos have been competing with cattle for food and water, a situation Blair said must be turned around "as soon as possible."
"Many farmers are taking livestock off their paddocks, only to then see kangaroos move in and take whatever is left -- this is the last thing any farmer needs at the moment," Blair said.
The new rules will increase culling quotas and more shooters to operate under a single license, a government press release states.
Australia has long dealt with harsh, dry conditions, especially inland, away from coastal areas popular with tourists. Prime Minister Malcolm Turnbull said earlier this week conditions were so bad that the country had to accept it was a "land of drought and flooding rains."
The drought may be Australia's worst in 400 years, according to a recent University of Melbourne study, which reconstructed 800 years of seasonal patterns.
The drought has hit farmers particularly hard, with crop, water, and fodder shortages putting their livelihoods at risk. Unable to feed their livestock, many have been forced to sell or slaughter stock, sending the cattle industry into a decline that could take years to recover.
There has also been a growing national conversation about the mental health toll that the drought has had on farmers. Young farmers under 35 are especially vulnerable to stress and negative effects of droughts, researchers at the University of Newcastle said in a recent study.
Turnbull addressed those concerns on Monday, announcing relief measures for farmers including extra money for mental health support services. Eligible households will able to apply for two payments of A$12,000 ($9,000) to help them get through the drought.
Separately, the state government announced a $500 million emergency relief package last Monday, raising the state's total drought support to more than A$1 billion.
Though Australia has long suffered from spells of drought, other parts of the world are currently experiencing extreme weather which experts say is evidence of the Earth's changing climate.
Heatwaves swept across Europe in July, leaving some farmers suffering drought conditions. The German Agriculture Minister warned of diminishing livestock feed, and the European Commission announced measures last Thursday to help farmers cope.
Countries worldwide are dealing with their own climate catastrophes. Japan and Korea are suffering heatwaves and wildfires have blazed across California and Sweden.
In a report released Monday, scientists warned that if global temperatures rise more than 2°C above pre-industrial levels, a domino effect will kick in leading to "hothouse" conditions and much higher sea levels.
Global average temperatures are around 1°C higher than in the pre-industrial age, and rising at 0.17°C per decade, scientists say.


For a list of APAR fixes, see the APARs fixed in 6.0.5 query.
For a list of non-APAR fixes, see the non-APARs fixed in 6.0.5 query.
For a list of known problems and workarounds that are published on Jazz.net, see the Jazz Foundation 6.0.5 workaround article query.


text:
Iain Hamilton Grant
Warwick University
Western philosophy
Speculative realism (transcendental materialism)
Main interests
Naturphilosophie, German Idealism, ontology[1]
Notable ideas
Transcendental materialism
Gilles Deleuze, Plato, Friedrich Wilhelm Joseph Schelling, Nick Land
Jeremy Dunham, Ben Woodard
Iain Hamilton Grant is a senior lecturer at the University of the West of England in Bristol, United Kingdom. His research interests include ontology, European philosophy, German Idealism (especially Schelling), and both contemporary and historical philosophy of nature.[1] He is often associated with the recent philosophical current known as Speculative Realism.[2]
2.1 Original works
2.2 English translations
Work[edit]
Grant was initially known as a translator of the prominent French philosophers Jean Baudrillard and Jean-François Lyotard. His reputation as an independent philosopher comes primarily from his book Philosophies of Nature After Schelling (2006). In this book, Grant heavily criticizes the repeated attempts of philosophers to "reverse Platonism," and argues that they should try to reverse Immanuel Kant instead. He is highly critical of the recent prominence of ethics and the philosophy of life in continental philosophy, which in his view merely reinforce the undue privilege of human being. Against these trends, Grant calls for a renewed treatment of the inorganic realm.[3]
Grant views Plato and Friedrich Wilhelm Joseph Schelling as his major allies among classic philosophical figures, and generally opposes both Aristotle and Kant for what he sees as their tendency to reduce reality to its expressibility for humans. Grant is also influenced by the French philosopher Gilles Deleuze.
Grant wrote his PhD thesis on Kant and Lyotard in the Department of Philosophy at Warwick University. Whilst at Warwick he was part of the Cybernetic Culture Research Unit.
He states "I am a philosopher working on ontology and post-Kantian philosophy and German Idealism, especially Schelling, and on the philosophy of nature both historically and in the contemporary context. I have published widely in these areas, and am writing a monograph on the problem of nature in later Idealism to follow my Philosophies of Nature after Schelling (Continuum, 2006). I maintain an interest in the philosophy of technology and in art."[4]
Bibliography[edit]
Original works[edit]
Co-authored New Media: A Critical Introduction (London and New York: Routledge, 2003)[5]
Philosophies of Nature After Schelling (London and New York: Continuum, 2006)[6]
Idealism: The History of a Philosophy (with Jeremy Dunham & Sean Watson) (Durham: Acumen, 2010) [7]
On The World Soul and Other Naturephilosophical Writings." Translated from the German by Grant, Iain H. New York: State University Press of New York. [Submitted] Available from: http://eprints.uwe.ac.uk/26289 '
Lindner, E. , ed. (2016) *Die Natur der Natur. Translated from the English by Lindner, Eckardt. Berlin: Merve. ISBN 9783883963723 Available from: http://eprints.uwe.ac.uk/26287 ' Dunham, J. , Grant, I. H. and Watson, S. (2011) *Idealism: The history of a philosophy. 1. Stocksfield: Acumen. ISBN 9781844652419 Available from: http://eprints.uwe.ac.uk/19359 ' Dunham, J. , Grant, I. H. and Watson, S. (2011) *Idealism: the history of a philosophy. London: Acumen. ISBN 9781844652419 Available from: http://eprints.uwe.ac.uk/12077 ' [8]
English translations[edit]
Jean Baudrillard, Symbolic Exchange and Death, transl. by Iain Hamilton Grant (London: Sage, 1993).
Jean-François Lyotard, Libidinal Economy, transl. by Iain Hamilton Grant (Bloomington: Indiana University Press, 1993).
^ a b "Dr. Iain Grant". University of West England Staff Profiles. Retrieved 3 May 2016.
^ Speculative Realism in Collapse: Journal of Philosophical Research and Development (Falmouth: Urbanomic, 2007), pp.306-449
^ ENR // AgencyND // University of Notre Dame (10 May 2007). "On an Artificial Earth: Philosophies of Nature after Schelling // Reviews // Philosophical Reviews // University of Notre Dame". Ndpr.nd.edu. Retrieved 21 September 2011. Cite journal requires |journal= (help)
^ https://people.uwe.ac.uk/Person/IainGrant
^ Lister, Martin; et al. (2003). New media : a critical introduction (Reprinted. ed.). London: Routledge. ISBN 978-0415223782.
^ A review of the book in the Notre Dame Philosophical Review
^ Dunham, Jeremy; Grant, Iain Hamilton; Watson, Sean (2010). Idealism: a history of a philosophy. Durham: Acumen Publishing Ltd. ISBN 9781844652419.
Profile at the University of the West of England
Webpage for Collapse journal featuring contributions by Iain Hamilton Grant and other "speculative realists"
New Media: A Critical Introduction, Second Edition
LNB: 000093834
Retrieved from "https://en.wikipedia.org/w/index.php?title=Iain_Hamilton_Grant&oldid=931444656"
British philosophers
Alumni of the University of Warwick
Academics of the University of the West of England, Bristol
Use British English from June 2017
Wikipedia articles with LNB identifiers
Year of birth missing (living people)