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Home Topics Cancer A "Very Good Year" for Roche
Molecular Diagnostics/In vitro Diagnostics
A "Very Good Year" for Roche
Roche today reported a 2% year-to-year increase in profits (1% at constant exchange rates), helped by rising demand for cancer drugs and diagnostic tests, as well as strong sales in the U.S. and emerging markets.
The Swiss-owned pharma giant said it finished 2012 with a net profit of nearly CHF 9.8 billion ($10.6 billion), up from CHF 9.5 billion ($10.4 billion) the previous year, on sales that rose 7% year-to-year (4% at CER), to CHF 45.5 billion ($49.7 billion). Core earnings per share rose 11% (10% at CER), to CHF 13.62 ($14.88).
"2012 was a very good year for Roche. We met our financial targets, grew faster than the market, and our strong pipeline positions us well for further growth," CEO Severin Schwan said in a statement.
Roche said the promising numbers reflected in part launches of three new cancer drugs. Zelboraf® for BRAF V600 mutation-positive metastatic melanoma rang up its first sales in Europe last year, more than doubling the drug's sales to CHF 234 million ($255.6 million). "Zelboraf performed well in Western Europe and the United States as a result of higher-than-expected BRAF testing rates. The growth rate of Zelboraf reflects the high unmet need in metastatic melanoma," Roche said in the statement.
Also launched last year in the U.S. and Switzerland were Perjeta for women with HER2-positive breast cancer, used in combination with Roche's Herceptin and chemotherapy. Perjeta generated CHF 56 million ($61.2 million) in sales last year, all but CHF 2 million ($2.2 million) of that racked up in the U.S.
That number should grow this year since Roche received a positive opinion for Perjeta at the end of 2012 from the European Medicines Agency's Committee for Medicinal Products for Human Use or CHMP. Roche anticipates launching the drug in Europe in Q1 2013.
Roche's third cancer drug launch last year was Erivedge for advanced basal cell carcinoma. Erivedge finished the year with CHF 29 million ($31.7 million) in sales, reflecting nearly a full year since the drug was launched in the U.S. in February 2012.
Roche also benefited from sales growth among existing treatments. MabThera/Rituxan, used for blood malignancies and rheumatoid arthritis, saw sales rise 9% to CHF 6.7 billion ($7.3 billion), while sales of Herceptin for HER2-positive breast and stomach cancers climbed 11% to about CHF 5.9 billion ($6.4 billion). Cancer drug Avastin was the company's third-best-selling drug at CHF 5.7 billion ($6.3 billion), up 6% from 2011, while sales of hepatitis C drug Pegasys grew 12% to CHF 1.6 billion ($1.8 billion).
The company's pharmaceutical division sales grew at the same 7% as Roche overall, to CHF 35.2 billion ($38.5 billion), though only 4% at CER. The diagnostics division, by contrast, rose 5% (4% CER) to CHF 10.3 billion ($11.2 billion) led by a 15% jump in its immunoassay business, though profits dipped 2% to CHF 2.2 billion ($2.4 billion) due to pressure to contain prices on diabetes care drugs.
For 2013, Roche is counting on sales from a planned launch this year of T-DM1 (trastuzumab emtansine), an antibody-drug conjugate for patients with HER2-positive metastatic breast cancer. T-DM1 consists of trastuzumab, the active ingredient in Herceptin, the chemotherapy agent DM1, and a linker that joins DM1 to trastuzumab. The drug is designed to target and inhibit HER2 signalling and deliver DM1 directly inside HER2-positive cancer cells.
Following promising overall survival data in the EMILIA Phase III trial—namely extending the lives of patients by 5.8 months in the second-line setting—Roche has filed for approvals to market T-DM1 in Europe and the U.S., where the treatment has been granted priority review in the U.S.
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redpajama_set_name: RedPajamaCommonCrawl


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Clinical Status
CMN-001
CAR-CIK
sCD83
Immunomonitoring
cGMP Consulting
Chimeric antigen receptor (CAR)-modified cytokine induced killer cell (CAR-CIK) technology featured at ASH
DURHAM, NC, December 16, 2020 (GLOBE NEWSWIRE) — CoImmune, Inc. today announced that its CAR-CIK technology was featured at the annual American Society of Hematology (ASH) meeting with an interim update on the phase 1/2 dose escalation clinical trial in B-cell acute lymphoblastic leukemia (B-ALL). The trial is being conducted at Ospedale San Gerardo, Monza, Italy by principal investigator Andrea Biondi, M.D. and at Papa Giovanni XXIII, Bergamo, Italy by principal investigator Alessandro Rambaldi, M.D. The presentation on was on December 7th during the immunotherapy session and was given by Dr. Chiara Magnani of the Tettamanti Research Center, Monza, Italy.
The clinical update summarized the results for 15 B-ALL subjects (4 children and 11 adults) infused with a single dose of HLA-matched or partially matched CAR-CIK CD19 cells manufactured from allogeneic peripheral blood donor cells. Following lymphodepletion and subsequent infusion, the CAR-CIK CD19 cells expanded reaching up to 70% of CAR+ T cells in the peripheral blood. Persistence of central memory CAR+ T cells was reported to be measurable up to 9 months after infusion. Of the 9 patients receiving the highest dose levels, 7 (78%) achieved complete remission at day 28 post-infusion. Six of the 7 CRs (86%) achieved minimal residual disease status. Dr. Magnani reported a high profile of safety in all treated patients with only grade 1 or 2 cytokine release syndrome at the highest dose level and no incidence of graft-versus-host disease, neurotoxicity, or dose-limiting toxicity.
"We are very pleased to continue to observe strong efficacy without serious adverse events and we look forward to continuing our collaboration with CoImmune to further advance the clinical development of this promising technology," stated study leader, Dr. Andrea Biondi.
"All of us at CoImmune are very excited by the work we are doing with our colleagues in Italy. We are planning additional clinical trials to be conducted in the United States and Italy targeting B-ALL, chronic lymphocytic leukemia, non-Hodgkin's lymphoma and acute myelogenous leukemia," said Charles Nicolette, Chief Executive Officer of CoImmune.
About CoImmune, Inc.
CoImmune is a privately held clinical stage biotechnology company specializing in the development of immuno-oncology therapies based on its two proprietary platform technologies. Its autologous RNA-loaded dendritic cell technology platform for solid tumors specifically targets each patient's unique tumor antigens; its allogeneic CAR-CIK technology platform is a variation on CAR-T therapy with greatly reduced toxicity while retaining strong efficacy.
For more information visit www.coimmune.com
Lori Harrelson
CoImmune, Inc.
4233 Technology Drive | Durham, NC 27704| 919-287-6300| Email Us
© Copyright 2021 CoIMMUNE


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Tag: DJ
"CLOUDS" is the latest highlight in what has been an incredible year for the young rapper, singer, DJ and producer. It follows on from her recently released "Can you" video…
Rising South African house DJ/producer Blanka Mazimela releases EP Gengesi featuring the talented Zimbabwe-born UK-based singer Oluhle on Shimza's new label, Kunye. Blanka Mazimela is one of South Africa's finest…
editor September 29, 2020
Music producer Franky Wah releases euphoric song 'You Don't Know'
Following on from lauded mixtape The Revival Vol. 1, Yorkshire DJ and producer Franky Wah returns with the euphoric sounds of new single 'You Don't Know', out today via Ministry…
Interview with DJ and Electronic music producer FreeedomB
Berlin-based Electronic music producer and DJ FreeedomB influence directly from the sound of jazz, funk or soul, from house music and Electronic rhythms. FreedomB is in search to create a…
Interview with Berlin-based DJ/Producer Vincent Marlice
Raised between Hamburg, New York and Santiago de Chile, producer and recording artist Vincent Marlice's background is as varied as his experience as a musician, including collaborations with Capital Cities'…
Interview with Ibiza DJ and producer Aracil.
Coming for a Musician family was at the young age of 17 when Aracil moved from the north of Spain to London, and discover his passion for the electronic dance…
UK DJ Patrick Topping shares latest European tour dates
Newcastle-born DJ and producer Patrick Topping has unveiled a European TRICK tour, named after his burgeoning record label. Running across five cities this October and November, the parties will be…
Interview with Music Producer/DJ Jamie Blanco
London born, live artist, DJ and producer, Jamie Blanco has with his remixes, original tracks and collabs created quite the solo career for himself outside of the Ess o Ess…
In Conversation With Vienna-based Electronic DJ and Music Producer Ken Hayakawa, discussing his Musical Background and Beats
[Image: Irina Gavrich]Ken Hayakawa is not your regular electronic musician. Born in Mozart's hometown, Salzberg, this multi-talented musician grew up playing classical piano, even performing in one of the most…
Interview with DJ Gonçalo Siopa
Gonçalo Siopa is Lisbon-based DJ, and host of the radio show Arrepio on Rádio Quântica. Siopa thrives to expand the upon booming Lisbon electronic music scene and beyond. Flowing between…


Clear distills the concept of behaviors, goals, and habits — things often over-complicated by tons of modern Thought Gurus — into applicable behavior systems. I started applying some of his suggestions before I even finished the book, and several weeks later, I'm still motivated and focused. I'd say that's a first for the end of January for me.
The post What I Read in January appeared first on The Art of Simple.


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Interview with Jason Bazinet of SMP - conducted via e-mail 3/8/98
Photos by Jester Copyright © 1998
Jester: Can you elaborate in detail about having your gear stolen over a year ago?
Jason: Sure. We were on tour with Noxious Emotion. We made it to Texas a bit early, so we decided to check into a hotel. We didn't notice that it wasn't such a nice part of the city at the time. When we woke up in the morning our trailer, which contained all our gear, was nowhere to be seen. Needless to say, it was a sad day for both bands and anyone who wanted to come out and see us that tour.
Jester: Have you been able to recover/replace most of it?
Jason: Oh yeah. We upgraded all our stuff after that. SMP now records in their own studio. My credit card companies love me.
Jester: I noticed that while you are no longer signed to Re-Constriction Records, yet you still appear on their specialty compilations and label samplers. Why is that?
Jason: Yeah, one of the biggest misconceptions about SMP is that we are still signed with Re-Constriction. Chase tells me people still ask him when our next CD is going to come out. Normally, Chase's specialty compilations contain songs from artists other than just the Re-Constriction roster, so that's pretty standard. I have no idea why he wanted us on the CMJ sampler, he just liked our song I guess. Lately, I've done some remix work for some Re-Constriction bands too, Collide & Hexedene.
Jester: Why did you choose to cover Public Enemy's 'Prophet of Rage' for "Operation Beatbox"?
Jason: Our first choice was 'Approach to Danger' by NWA, which I wish we would have done instead because NWA should have been represented on that disc. And there were two Public Enemy songs on the compilation too. We liked 'Prophets of Rage' because of the delayed vocals in it. We did the delays with backing vocals instead of effects and it turned out pretty cool.
Jester: Why did you choose to cover 'Metro' by Berlin for "Nod's Tacklebox of Fun"?
Jason: We just liked the song and we thought we could make that song sound good, SMP-style. Plus it's cool to do a cover of female vocals. It's a love song too, so that was different for SMP. It was fun to put together.
Jester: Did you know that San Francisco based Gridlock had already done before?
Jason: No. The Metro cover is years old. Re-constriction has been sitting on the Metro recording for close to a year. SMP was doing a show in Sacramento with Scar Tissue when the DJ played Gridlock's version of Metro. I actually hadn't ever heard of Gridlock before either. It doesn't really bother me that the song has been covered before, as long as the SMP version is better, that is.
Jester: How did you approach writing lyrics for the Vampire Rodents 'Revisioned' track from "Clockseed"?
Jason: Very quickly. Sean and I slam-dunked the lyrics to that song unfortunately. It's not our favorite song. I'd like to do something with Daniel again sometime though.
Jester: You also have appeared on a fair number of independent compilations recently. Have you done this in a continued effort to get noticed by other labels?
Jason: More importantly we do these compilations in a continued effort to get noticed by Industrial fans. The reason we didn't do them before is they weren't really around when we first started up. Now that everyone and their brother is on-line it's easier to network and the cost of CD manufacturing has gotten cheaper as well. All it takes is ambition and persistence to release your own CD. It's cool because it gives the record companies less control over what is heard and what is not.
Jester: What lead to Sean Setterberg leaving SMP and the addition of two new band members?
Jason: Sean started SMP with me. I've known him forever. We went to high school together and played in many bands together. He just wasn't having a good time with SMP anymore. Maybe he was burned out on SMP, I don't know. Christ Analogue asked him to join their band and he accepted. It wasn't any knock down fight or anything like that.
After Sean left the band I needed more musicians. We auditioned drummers and Matt was one of the first we auditioned and we liked him, as well as his playing, so we asked him to join the band. Guitarist Rick Aguilar, who performed on two SMP songs, was replaced later by a drummer named XianDi.
Jester: Do the two new members contribute to the writing process of new material?
Jason: Matt has contributed programming to two songs on the Ultimatum CD. Also, SMP's music isn't just created in a computer from start to finish. It starts in the computer then goes to the practice studio where we work on it and talk about what should be done with it. XianDi and Matt also will be playing the drums on the CD.
Jester: I noticed that your live shows contain almost exclusively new material with only a single older track. Why is that?
Jason: We just got sick of playing our old material. Sometimes I forget that other people want to hear that old stuff. It boggles my mind when I hear about bands touring on the same material for years. The Seattle crowd has heard our older stuff a lot as well. When we tour this summer we will definitely be playing some of the "Stalemate" stuff for people who haven't had the chance to see us live.
Jester: Now that you have completed the "Ultimatum" demo, how have labels been responding to it?
Jason: After talking with several labels we decided to release the 17 song CD on Catastrophe Records located here in Seattle.
Jester: How did you first get involved with writing and composing music?
Jason: I started out playing the drums in various bands, I've played Rock/Wave/Goth and Punk. In the last band I was in, before SMP, the way we approached writing songs would be to program them on the keyboard and have everyone learn from the sequences. I always wanted to write music and I had ideas for songs but was never able to write since I could only play the drums, so I jumped at the chance to start programming. I started singing when SMP was formed.
Jester: Have any members of SMP ever had any type of formal musical training?
Jason: I've been playing the drums since the 4th grade so I've had some lessons through school. Matt went to the Seattle Drum School to learn to play as an adult and XianDi went to some drum school down in California to learn as an adult. Matt & XianDi have played in various rock-type bands and I've done some jazz as well.
Jester: What does the future hold for SMP?
Jason: Well we have a CD coming out in May. A tour will be scheduled for this summer. After that who knows?
Jester: Is there anything you would like to add that I have not covered?
Jason: Yeah. One of the other big misconceptions about SMP. What the HELL does SMP stand for! Last night, after opening for Mentallo & The Fixer, some guy told me he heard it stood for Smoke More Pot. I've heard a few pretty funny ones. SMP is the name of our product.


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POLITICO NOW Blog
Ex-McCaskill staffers launch PAC to block Hawley's electoral ambitions
Becerra: Dems willing to tackle entitlements
By BYRON TAU
Democratic supercommittee member Rep. Xavier Becerra (D-Calif.) pushed back Sunday against claims that Democrats were not willing to tackle popular entitlement programs in order to forge a deficit deal.
"Every plan that Democrats have put forward has included cuts to entitlement programs. Some deeper, the bigger the deal. Some smaller," Becerra said on "Fox News Sunday."
Becerra was responding to an emerging Republican narrative that the supercommittee was deadlocked and likely to fail over Democratic refusals to reform Social Security and Medicare.
"Everything has been on the table including reform of our entitlement programs," Becerra Fox host Chris Wallace. "The increase in eligibility has been on the table. And depending on what's in the package, it might have be or something that could be something that's in the package."
Becerra also said he believed that a last-minute deal was still possible.
"I believe there's a deal out there. I believe there's a better deal than letting automatic cuts," he said. "We still have an opportunity to go somewhere."


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Debito Arudou
Author/activist with Japanese citizenship born in the USA
Debito Arudou (有道 出人 Arudō Debito; born David Christopher Aldwinckle in 1965) is a naturalized Japanese citizen who is a teacher, author and activist.
This article about an activist is a stub. You can help Wikiquote by expanding it.
WaiWai was an essential guide to Japanese attitudes and editorial directives.
("Defending the weeklies, as well as Connell and his collaborators, is the unflagging media critic and campaigner for human rights Debito Arudou, who wrote that WaiWai was an essential guide to Japanese attitudes and editorial directives.") Justin Norrie, "Japan rails at Australian's tabloid trash", Brisbane Times (2008-07-05)
Too many Japanese believe that they can say whatever they like in Japanese ('that statement was for a domestic audience' is very often an excuse for gaffes), as though Japanese is some secret code."
Debito Arudou on defending the Japanese weeklies, as well as Ryann Connell and his collaborators, by suggesting that the Mainichi Shimbun's now defunct WaiWai column was "an essential guide to Japanese attitudes and editorial directives." Justin Norrie, "Japan rails at Australian's tabloid trash", Brisbane Times (2008-07-05)
Other people have called me a "human rights" activist. I don't mind the label, but I don't think I'd go so far. It puts me on par with other extraordinary activists. I'm just an average guy with a bigger mouth than average.
Interview, JapanReview.Net (2001-11-17)
I guess the clarification I should make here is that Japan is as potentially racist as anywhere else, but for a developed country, the legal and social protections and recourses afforded to people of differences are lacking comparatively. Racial discrimination is still not illegal in Japan, and this is something the Japanese government promised to fix when it signed the UN Convention on it in 1995. In short, Japan is not an outlier in terms of racism, but it is in terms of protections against it.
Truth be told, having two passports in Japan is not necessarily a problem. If one lived a quiet life, one could conceivably keep renewing a non-Japanese passport ad infinitum. The USG permits dual citizenship and doesn't go out of its way to tell other governments about the nationalities of their citizens. However, as you know, I don't live a quiet life.
"How to Lose Your American Passport", Debito.org (2003-01-10)
Starting from 1993 in Otaru, Hokkaidō, and now running unchecked throughout Japan, signs saying 'Japanese Only' have gone up, making an unspoken undercurrent of fear of the outsider into clear, present, and brazen exclusionism — following the best traditions of segregation and apartheid.
"The Rogues' Gallery: Photos of Places in Japan which Exclude or Restrict non-Japanese Customers," Debito.Org (last revised November 2007)
[To] me naturalization is just an obvious extension of what somebody in my position would desire anyway — the right to vote and to legally participate in society the same as any other citizen. I am already as entrenched as any other citizen: I have a house and land with a debt of a quarter-million dollars; with a thirty-year loan I really cannot leave Japan… Moreover, naturalization has knock-on benefits that suit a person with my personality. It will enable me to stand on my rights (yes, more than I do now!) with renewed vigor — because I will indeed have more rights, as well as a firmer ground to demand even more (I can except myself from, say, this 'as a foreigner, you are a guest in our country so shut up' bullshit). And — dare I say it? — I would be able to participate in politics as a candidate if I so choose).
Debito Arudou, "A Bit More Personal Background on Arudou Debito/Dave Aldwinckle," Debito.Org
Debito Arudou's homepage
Retrieved from "https://en.wikiquote.org/w/index.php?title=Debito_Arudou&oldid=2724293"


Burning fat has always been the goal of most people especially after the holiday is over because of the weight gained over the few weeks which is not surprising given that we tend to indulge during this season. And although you have a workout plan in place, and have started cutting back on your calorie intake, sometimes, the results are still not showing. That being said, the use of fat burners for this year won't disappear any time soon, as more and more people are looking for additional support for their weight loss plans.
With the demand for fat burners going up, you'll probably come across numerous brands in the market today. But how will you know which one to use? Here we have gathered some of the best fat burners that will stay in the lead this year.
Still leading the pack in terms of fat burners, Alpha Lean-7 remains the top supplement for burning fats for the past three years. Customers who have been using it were pleased with the effects of this fat burner in terms of suppressing their appetites as well as for its thermogenic properties too. This may be a good place to start if you are planning on using a fat burner to help you shed weight.
Another fat burner that had made the cut is Lean Mode which not only boosts metabolism, but can also reduce your appetite. Among its key ingredients include green coffee bean extract, acetyl-l carnitine, conjugated linoleic acid, garcinia cambogia, and green tea leaf extract. The hydroxy citric acid that is present in Garcinia Cambogia can help suppress appetite which means that you are less likely to gorge on food.
For those who want to burn fat while building muscles, the Muscle Sculptor may be the supplement that you are looking for. This is a 2-in-1 supplement that works as an efficient fat burner, and at the same time, acts as a natural anabolic that can help strengthen and even harden the muscles. This works well with those who are aiming for a more chiseled body. Those who have used it before remarked of their steady weight loss which is something to consider.
A gluten-free fat burning supplement that focuses on giving you energy while boosting your metabolism may help you achieve the desired weight. The combination of choline bitartrate, theacrine, and caffeine has been found to be effective in transforming fats to energy hence the metabolism rate goes up. The presence of caffeine and theacrine helps keep you wide awake and alert during the day.
It is likely that Animal Cuts will also be the go-to brand for fat burning supplements because it does more than help you tone your physique. It also helps provide you with endurance and stamina to perform better during your training for more fat burning sessions. The combination of caffeine as well as raspberry ketones creates a stimulant complex that can help you burn more fats while raising your energy levels.
For those who can tolerate taking stimulants, this fat burning supplement may help you strip off the excess fats. This is only recommended to those who have been using fat burners already as the ingredients may be too strong for those who are just starting out. Still, it is one of the best fat burners that you can get in 2019.
Fat burners may help you gain the weight and figure that you are aiming for too, which is why checking out their list of ingredients and the benefits that they provide can help you choose the right one for you.


Guangdong Xinruncheng Ceramics Co., Ltd., is one of the largest professional production of ceramic tiles of the modern enterprise, has two large-scale modernized production base in Guangdong Foshan, the plant covers an area of nearly 500 thousand square meters, marketing outlets throughout the country. The introduction of the most advanced automatic production line of Italy, SACMI 7200 compressor, HD inkjet printers, the most advanced long kiln and first-class equipment, the production of 600mm * 600mm to 1200mm * 1200mm and other more than 300 varieties of different specifications of ceramic products, Ceramic tile annual output of about 30 million square meters, the products are exported to more than 100 countries and regions around the world.
Guangdong xinruncheng Ceramics Co., Ltd.
Copyright©2018 Guangdong Xinruncheng Ceramics Co., Ltd.


Continue to provide sound financial stewardship of taxpayer funds to continue reducing the debt and provide for solid District operations.
The GVR Metropolitan District has put together and biannually examines and adjusts as needed a Strategic Plan for the organization. Please see the below link to download the 2009 Strategic Plan.


Feb 27, 2013. The Always On crew straps on the GoPro Hero3, Swann Bolt HD, and iOn Air Pro 2, and tests out the cameras' durability and performance on.
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Cette page regroupe les évènements concernant les Croisades qui sont survenus en 1169 :
 2 janvier : mort de Bertrand de Blanquefort, grand maître de l'Ordre du Temple.
 8 janvier : Chirkouh, lieutenant de Nur ad-Din devient vizir d'Égypte.
 6 février : mort de Thoros II, seigneur arménien des Montagnes.
 23 mars : mort de Chirkouh, vizir d'Égypte. Son neveu Saladin lui succède.
 16 octobre : Amaury  quitte Ascalon à la tête d'une armée pour tenter de conquérir l'Égypte sur Saladin.
 25 octobre : Amaury  de Jérusalem et son armée pénètrent en Égypte à Farama.
 27 octobre : Amaury  de Jérusalem met le siège devant Damiette.
 13 décembre : Amaury  de Jérusalem doit lever le siège devant Damiette, à cause de la mésentente entre les latins et les grecs.
 Melh, soutenu par Nur ad-Din détrône son neveu Roupen II, prince de l'Arménie cilicienne.

Références

Chronologie des croisades

redpajama_set_name: RedPajamaWikipedia


MORLEY — It was quite the season for the Morley Stanwood boys basketball team.
The Mohawks reeled off 12-straight victories to start the season and finished with an 18-2 record and a CSAA Silver championship in hand. Morley Stanwood lost to eventual D3 champion Pewamo-Westphalia 50-32 in its district semifinal game.
The Mohawks went 10-0 in Silver play to clinch an undefeated conference season.
Winning the conference title, "was one of our goals," Morley Stanwood coach Bob Raven said. "We thought we had a team which could maybe win it.
Among the team's 18 wins included a 53-30 season-opening win against rival Big Rapids, a 59-52 win over a Division 1 team in Greenville, a close 50-47 win over Reed City, and 73-62 and 62-50 wins over conference rival Kent City.
The Mohawks were among the best teams in the area, averaging 64.6 points per contest while giving up just 43.4 points for an average margin of victory of 21.2 points.
Leading the way for Morley Stanwood was junior Aiden McLaughlin with 11.9 points, 3.0 rebounds, 2.8 assists, and 2.0 steals per game. Junior Axel Woolworth was second on the team with 11.5 points and was tied for first in 3-pointers made with 60 (42 percent shooting). Senior Landon Elenbaas averaged 11.4 points and was tied with Woolworth for first in 3-pointers made with 60 (39 percent shooting) while averaging four rebounds.
With players like Woolworth, Elenbaas, and McLaughlin lighting it up from outside, the Mohawks broke the school record for 3-pointers made in a game with 18 in a 72-40 win over White Cloud on January 11.
Dillree was a Swiss Army Knife for the Mohawks, averaging 8.7 points, 5.4 rebounds, 2.5 steals, and 2.9 assists per game while leading the team in blocks with 15 from the point guard position. McLaughlin, Woolworth, Elenbaas, and Dillree each made the CSAA Silver all-conference team.
Morley Stanwood loses a successful senior class in Dillree, Elenbaas, Xavier Raven, Trevor Underhill, and Kyle Ososki. The quintet compiled a 36-6 over the last two years.
Their skill and leadership will be missed, but the Mohawks return a talented group next year with McLaughlin, Woolworth, Jason Bialek, and Carter Veldkamp all expected to come back.


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Home News Regulating Gene Expression by Force
Regulating Gene Expression by Force
Scientists at the University of Illinois and collaborators in China say they have demonstrated that external mechanical force can directly regulate gene expression. Their study ("Transcription Upregulation Force-Induced Firect Stretching of Chromatin"), published in Nature Materials, also identified the pathway that conveys the force from the outside of the cell into the nucleus.
Identifying the ways mechanical forces send signals within cells has applications not only in fundamental cell biology, but also for cancer, stem cells, and regenerative medicine, said mechanical science and engineering professor Ning Wang, Ph.D. who led the study with cell and developmental biology professor Andrew Belmont, Ph.D.
"Each cell in your body has the same DNA, but tissues behave very differently because genes are expressed differently," Dr. Wang said. "There is so much we don't know about gene expression. I think this work is the beginning to unravel some of the unknowns."
Researchers have long known that forces, both external and internal, can affect cell behavior. But the question loomed as to whether the forces themselves triggered changes in gene expression, or if the forces triggered a chemical-signaling pathway within the cell.
"Cells only have two 'senses' to interact with their environment," Dr. Wang explained.. "They cannot see or hear, but they can 'feel' mechanical forces and 'taste' chemical signals. Many studies have detailed chemical-signaling pathways, but it's important to understand how the mechanical forces affect the cell as well. Mechanical signaling is as important as chemical signaling, and this study shows it's a direct pathway."
The researchers stuck tiny magnetic beads to proteins attached to the external membranes of hamster cells. They were able to change the direction and angle of the force the beads exerted while maintaining a consistent magnitude of the force and found that the external force directly caused regions of chromatin in the nucleus to stretch out. Using advanced imaging techniques, the researchers found an increase in transcription of the genes in the stretched regions.
"Work extending back decades has correlated chromosome decondensation with increased gene expression, but it has been extremely difficult to distinguish cause and effect," Dr. Belmont said. "Does gene activity cause chromatin to decondense, or does decondensation actually drive increased gene expression? Here, we saw chromatin stretching directly drive increased gene expression, which provides a mechanically based mechanism for cells to sense their environment."
The degree of stretching and therefore gene expression varied based on the direction of the force in relation to the cell's cytoskeleton, the internal framework of protein tubes that supports the cell.
"The actin in the cytoskeleton forms bundles. When the force is perpendicular to the bundles, it's like plucking violin strings," according to Dr. Wang. "It's incredibly tense, and the signal is transferred through the cytoskeleton to the nucleus and stretches the chromatin. Doing it the other way, along the string direction, there isn't much vibration, so a force of the same magnitude has less effect. The effect gets stronger the closer the angle gets to 90 degrees."
The researchers were able to follow the force and identify the pathway that it travels along the cytoskeleton to the chromatin in the nucleus. Knowing the pathway is important because researchers can now explore mechanical signaling in more detail and perhaps develop ways to harness it for gene regulation or identify targets for cancer therapies.
For example, Dr. Wang's group has published several studies detailing the unique mechanical properties of tumor-repopulating cells, i.e., cancer cells that evade standard drug therapies and tend to slip away to metastasize in new locations. He hopes that this study opens new avenues of attack to disable tumor-repopulating cells with fewer side effects than traditional cancer treatments.
Now that they've detailed how forces affect stretching of the chromatin, the researchers are beginning to look at how forces affect chromatin compression and what that means for gene expression. They are also probing further into other factors regulating gene expression when the chromatin is stretched.
"When we apply these forces, why are some genes activated while some are not? We think there are factors that inhibit, so that some genes are not ready to be force-activated," noted Dr. Wang.
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text:
Erdélyi György (Kolozsvár, 1923. április 13. – Budapest, 1983. február 21.) magyar újságíró.

Életrajza

1934-től Budapesten élt. Miután a polgári iskolát elvégezte, bőrdíszműves-inasnak állt, 1942-ben munkaszolgálatra hívták be, 1945 elején Budapesten szovjet hadifogságba került. Miután hazatért, 1948-50-ben politikai munkatársaként dolgozott a Magyar Szabadságharcos Szövetségnél. 1950 és 1958 között napi- és hetilapoknál volt újságíró. 1959 és 1964 között elvégezte a Színház- és Filmművészeti Főiskola rendezői szakát, majd 1964-65-ben főelőadóvá nevezték ki a Művelődési Minisztérium színházi főigazgatóságára. 1965-től 1970-ig a Néphadsereg című lap olvasószerkesztője, 1970-től egészen haláláig a Népszava olvasószerkesztőjeként dolgozott.

Műve

 Huta a Bakony alján 1878-1978. Riportok, beszámolók a 100 éves Ajkai Üveggyárról (Barta Évával, Székely Jánossal, Veszprém, 1978).

Források

 Magyar életrajzi lexikon

Magyar újságírók
Kolozsváriak
1923-ban született személyek
1983-ban elhunyt személyek


text:
package io.skygear.plugins.chat;

import io.skygear.skygear.Error;
import android.support.annotation.NonNull;
import android.support.annotation.Nullable;

/**
 * The callback interface for getting objects.
 *
 * @param <T> the type parameter
 */
public interface GetCallback<T> {
    /**
     * Success callback
     *
     * @param object the object
     */
    void onSucc(@Nullable T object);

    /**
     * Fail callback
     *
     * @param error the fail reason
     */
    void onFail(@NonNull Error error);
}

redpajama_set_name: RedPajamaGithub


Now this is a real ladies man.
A man in China has some serious explainin' to do after he got into a car accident and his 17 girlfriends -- none of whom knew about each other -- came to visit him in the hospital when doctors made some phone calls to inform people what happened.
His injuries were minor, so you just know they paled in comparison to the hearts he broke in one fell swoop.
We've already had a son together. What can I do now? I don't love him any more, but I do love my son."
Seventeen girlfriends is remarkable. It's like he went speed dating and he picked everyone who picked him. We'd love to meet this guy and ask how he found the time to juggle all his ladies because while it may a tad bit cad-like, it's also pretty impressive that he could pull this off for so long.
The women you're romantically involved with should never be more than a fortnight, the number of eggs in a standard carton or nostrils in your nose. This guy, though, did not get the memo and we can only assume he'll pop up soon enough on China's version of Maury.


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Avira is yet another prolonged-operating Home windows virus specialist, Launched in the eighties and based in the southernmost edge of Germany in Tettnang. Its most widely used merchandise was AntiVir and is frequently recognised from the trademark umbrella brand.


text:
Remembering teachers past
JAMES ZEMAN, a 1956 graduate of Chadron High School, returned to CHS to teach English and Speech in 1960-61 after graduating with a Bachelor's degree from Nebraska State Teachers College at Chadron in 1960. It would be the first of his 42 years in the teaching profession.
"I thoroughly enjoyed teaching the senior English class that year," Zeman told us. "I still remember fondly the senior class play, and I can't forget Murray Schmechel coming out on stage in the barrel in "Tons of Money." That was Zeman's only year of teaching at CHS.
He spent the next six years teaching speech and coaching speech activities at Lead (SD) High School while working summers to complete an M.A. in Speech Communication. After a one-year stint back at Chadron State as a one-year replacement, he signed on at Northern State University in Aberdeen, SD to teach speech and handle forensic activities. It turned out to be a 34-year gig. He completed a Ph. D. in Speech Communication at Pennsylvania State University and was very actively involved with the South Dakota Education Association for many years.
Jim Zeman retired in 2003 as a full professor at Northern State and spends his time in both Aberdeen and the Black Hills region – as well as a couple of weeks each year on the Oregon coast.
Early Chadron: Hollywood of the Plains?
As Chadron Prep grads assemble


text:
Major US Carriers: We're Taking Over RCS Rollout
Verizon, AT&T, T-Mobile, and Sprint announced they're working on the 'Cross-Carrier Messaging Initiative' to simplify texting between all devices.
By Justin Herrick
https://www.pcmag.com/news/major-us-carriers-were-taking-over-rcs-rollout
Traditional texting falls short of what other messaging apps can do, but US carriers are collaborating on a new standard that aims to usher in next-generation features.
Verizon, AT&T, T-Mobile, and Sprint this week issued a single press release laying out their strategy to replace SMS. The joint venture, known as the Cross-Carrier Messaging Initiative(Opens in a new window) (CCMI), takes on Rich Communication Services (RCS). Built by the GSM Association, RCS unlocks access to an upgraded communication experience.
RCS enables features such as read receipts, a real-time typing indicator, and larger file attachments. Businesses, too, benefit by using RCS to directly communicate with their customers.
In the last few years, Google's strategy for RCS-based texting shifted from relying on carriers to flipping the switch itself. Google introduced its own standard, called Chat, on Android devices in the United Kingdom and France back in June. Additional countries are set to gain support in the coming months, and all Google needs to do is modify servers to welcome users.
Google appears to be committed to the CCMI's standard as well, though. In a statement issued to The Verge(Opens in a new window), the Mountain View-based company applauded the US carriers' latest approach. So there might be at least a small chance the CCMI's standard gets included in the dedicated Messages app on Android devices.
The good and bad news for iPhone owners: iOS support hasn't been ruled out, but Apple's staying quiet on its interest in RCS as iMessage already dominates among its users. It'd be nice to see Apple work with US carriers as consistency is vital for any RCS standard to succeed. Of course, there's no indication that Apple cares enough about that when iMessage exists as a huge selling point for its hardware.
RCS-based texting with the CCMI's standard should arrive in 2020. Verizon, AT&T, T-Mobile, and Sprint say they'll release a pre-installed app on Android devices to easily get the technology to millions of customers. It'll also be offered on some existing smartphones through the Play Store.
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Samsung Galaxy S23: How to Pre-Order and Get the Best Deal
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About Justin Herrick
Justin is easily attracted to power buttons. His interest in technology started as a child in the 1990s with the original PlayStation, and two decades later he can't keep his hands off the latest gadgets. His work has appeared in TechnoBuffalo, Talk Android, Business Insider, and other award-winning publications. If you're interested in his latest ramblings, drop Justin a follow on Twitter @JustHerrick and Instagram.
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How to Livestream Sony's PS5 Event
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You just wrapped up a conversation with your MemberWhen Storyographer. You put your phone down and suddenly think, "I didn't say anything useful. I sounded terrible. My gift for my mom is ruined!" Fear not! You did great and I'm going to tell you why.
At MemberWhen, we edit your conversation with your Storyographer to create your completed MemberWhen episode. That means that any "Umm…" "Well…" or, "Shoot let me think a second…" can be taken out if it distracts from the memory or thought that you're sharing.
A few words here or there have been cut out and the long pauses have been removed. The sentiment is completely the same, but the words have been cleaned up a little bit. We use editing to help you sound your best so that you can focus on what you want to say rather than how you need to say it.
Most MemberWhen episodes feature multiple voices sharing their favorite stories and memories. It's fun to hear all of the voices interact. On top of that, having multiple participants in your MemberWhen means that you don't have to do all of the work when it comes to sharing stories.
Say you purchased a MemberWhen episode as a gift for your brother and you decide that the participants will be you, your two parents, and your sister. You're all going to share your favorite memories about your brother. Maybe you forget to share the story of the time your brother dyed his hair pink– that's ok because your parents shared that story. And maybe your sister forgot to mention that time your brother nearly ruined Thanksgiving. That's fine because you told that story as if it just happened yesterday.
You don't have to remember every little thing. Having different voices tell different stories is one of the best parts of a MemberWhen episode.
I'm going to let you in on a little secret. The best part of any MemberWhen episode… the thing that makes it unforgettable… the secret sauce is… you. Whether you're giving a MemberWhen episode as a gift or you're creating something that your children can enjoy decades from now, all you need to do is be yourself and everything is going to be great. The magic of listening to a MemberWhen episode is hearing people you care about be themselves. There's nothing quite like hearing your dad talk about the time he saw your mom for the first time or hearing your daughter talk about what you mean to her. You don't need to worry about saying the "right thing." There are no right answers. Just be yourself and your MemberWhen episode is going to be amazing.


His classic red-and-blue costume destroyed during the Secret Wars, Spider-Man acquired a new black costume with a white spider on its chest, first as an alien symbiote bonded to his body, later as a cloth costume not unlike his old red-and-blue costume.
This stunning statue of Spider-Man's black costume is digitally sculpted by the Kucharek Brothers and stands 12" tall atop a base.
Alien (Film) Xenomorph "Big Chap"


We are recruiting for Full-Time Car Washers. Requirements include ability to drive a manual transmission vehicle, be at least 18 years of age and possess a current valid drivers license.
This is a physical, fast paced job that requires both interior and exterior cleaning of the UPS vehicle fleet using hand held tools including a long handled brush. Car Washers are required to position vehicles and must be proficient driving 5-speed manual transmission vehicles.
The typical work period for Part-Time Car Washers is Monday through Friday, late afternoon and early evenings.


Theresa Cox | Rubin & Badame, Attorneys at Law, P.C.
Theresa joined R&B after completing her second year of graduate school at Temple University, where she also holds a B.A. in Psychology and Associate's Degree in History. With over a decade of experience working with persons with disabilities, and helping to coordinate services to communities, Theresa has brought her passion to help others to R&B. When not working, Theresa enjoys hiking, swimming, and spending time with her niece and nephews. She also volunteers her time for various community organizations and events to raise mental health awareness.


text:
Carriera
Ha giocato nella prima divisione scozzese.

Note

Altri progetti

Collegamenti esterni

Calciatori inglesi


It's that time of the month again! Time for the release of the July pattern for the Adventurous Stars BOM I am hosting this year.
This is my Plaid Star, I love the checkerboard effect of the background on this one!
The link to the download site is at the top of my left sidebar.


Home / brand new / brand new artist / Charles Fauna / música / Charles Fauna Unveils New Single "Something Human"
Charles Fauna Unveils New Single "Something Human"
Brooklyn-based singer-songwriter, producer Charles Fauna has just unveiled his brand new single Something Human, taken from his upcoming Eulogy EP.
The song packs quite a lot of emotion and nostalgia over a super smooth and calming production packed with dreamy synths. There's an 80s pop vibe of the song that got me hooked after the very first listen. I love the way his vocals provide the song with a dream-like and ethereal vibe. The groovy guitar riffs stand out in this smooth production and give the song a cool edge. This is such a great song guys. It's perfect for those long road trips or those chillout weekends at home. Stream it below!
'Something Human' is about letting go of love as an absolute. As a cure all for every problem. As as all that we need. It's a song about looking for something bigger. Some feeling, some greater connectedness that we are too preoccupied to experience because of how afraid we are of not having love in our lives. Something that binds us to systems of life, nature, and each other. I get flashes of this feeling, but I don't know what it is or how to describe it. The song is asking someone, anyone, for help in finding that elusive kind of connection.


Being the leading supplier, manufacturer and distributor of branded dental radiology products like RVG sensors, Intraoral cameras, Portable X-ray DC camera, Dent-O-DC X-ray machines in India and Abroad, ODI technologies has moved one step up in its proficiency and skills by introducing one of the exclusive X-ray device in the segment of scissor armed X-ray machine.
At ODI technologies, today we are feeling proud to launch one of the finest and articulate X-ray devices named "Optident Series". This is one of the long armed machines which are encompassed with some of the exclusive features that are enabling a radiologist to use the machine with full efficiency and great comfort. ODI technologies have the motto to work for the convenience of its prospective customers so that they have no trouble while operating our technically strong dental products.
Keeping innovations our prime goal, the team of ODI technologies are engaged in launching aesthetically designed and best featuring dental radiology products for the superficial use of the dental practitioners.
Today, we are quite confirmed that Optident Series, AC X-ray machine is one of our superior products which will be meeting entire dental imaging requirements of a wide range of dentists. On the other hand, our Ac X-ray machine is meant for reducing huge discomforts sensed by the patients while taking the diagnosis of oral area.
With lots of specialties, our AC X-ray machine has become one of the promising devices for the progressive dentists and radiologists who have a thought of developing their expertise at the time of undying competitions. Since this device enriches you extraordinary competencies that can be taken in use for capturing high resolution images of oral areas. The sharper and clear cut images obtained through our AC X-ray machines would enable the dentist to diagnose serious dental defects or infections in the minimum possible time.
OPTIDENT series AC X-ray Machine is perfect equipment in the present time which entails the manual selection of exposure time and offers guaranteed compatibility with all kinds of the digital sensors available in the market. OPTIDENT series is exceptionally good and stable machine in terms of quality and performance. This machine is amazingly light and easy to operate in diverse environment.
The engineering team of ODI technologies has taken utmost care in preparing the design of Optident Series. The new scissor arm of AC X-ray machine is ensuring quality operation and perfect approach for effective diagnosis.
To deliver quality results in complex installations, Our AC X-ray machine is incorporated with a remote control panel that enables a radiologist to initiate an exposure just being outside the examination room. This is one the added advantages of our machine which protects a radiologist from the bad effect of harmful leakage of radiations.
TECHNICAL DATA: We are quite hopeful that our AC X-ray machine would make a mark in the industry with its exclusive feature and quality results. In case, you have any requirement to induct this device in dentistry profession then please forward your necessary requirements to us on dental@giindia.in. We would revert to you with most satisfactory responses for your needs.


text:
Alexander Theodor von Middendorff (oroszul: Александр Федорович Миддендорф, Alekszandr Fjodorovics Middendorf) (Szentpétervár, 1815. augusztus 18. – Hellenurme, Palupera község, 1894. január 24.) balti német származású orosz felfedező és természetbúvár.

Élete
Theodor Johann von Middendorff (1776–1856) és Sophia Johanson (1782–1868) fia. Természettudományokat tanult és 1839-ben a zoológiai tanszék adjunktusa lett Kijevben. 1840-ben beutazta Lappföldet, 1842-45-ben Szibériát, egészen a felső Amurig. Ezt megírta Reise in den äussersten Norden (Szentpétervár, 1848-75) című könyvében. A tudományos akadémia évkönyveiben 1855-ben kiadta Die Isepiptesen Russlands című dolgozatát és 1840-ben Baer és Helmersen gyűjteményében (Beiträge zur Kenntniss des russischen Reiches) Lappföld faunáját írta le. 1867-ban Alekszej nagyherceget kísérte oroszországi útján, 1869-ben Vlagyimir nagyherceget, 1870-ben Alekszejt Novaja Zemljára és a Fehér-tengerhez. 1878-ban pedig a Ferganai-medencébe utazott, amiről Einblicke in das Ferghanathal (Szentpétervár, 1881) című könyvét írta. Middendorff 1845-től tagja, 1855-57-ben titkára volt az orosz tudományos akadémiának.

Jegyzetek

Források

 Hubertus Neuschäffer: Middendorff, Alexander. In: Neue Deutsche Biographie (NDB). Band 17, Duncker & Humblot, Berlin 1994, , S. 463 f. (Digitalisat)

 Erki Tammiksaar, Ian Stone: Alexander von Middendorff and his expedition to Siberia (1842–1845). In: Polar Record. Band 43, Nr. 3, 2007, S. 193–216.

Orosz zoológusok
Balti németek
1815-ben született személyek
1894-ben elhunyt személyek
A Szentpétervári Tudományos Akadémia tagjai


You and your bike are welcome on the bus.
All Citilink fixed route buses are equipped with bike racks.
Rack & Roll... bring your bike on the bus!
Learn how to extend your trip or enjoy the Greenway by bringing your bike on the bus! Ride the bus one way and ride your bike the other. Extend your range and avoid areas not conducive to bicycling by riding the bus.
Don't have a bike of your own? That's okay, try Fort Wayne's bike share program.
Membership in the Fort Wayne bike share is open to all members of the public 18 years of age or older. While you are using a Zagster bike, you are free to ride it wherever you like!
Learn more about Fort Wayne's bike share program.
Please view this entertaining instructional video on "How to Use a Bike Rack".
Are you and your bike ready to Rack & Roll?
Wait until the bus has come to a complete stop. Tell the bus driver you are loading your bike. Load from the curbside only. Be aware of traffic and blind spots. Pull down the bike rack mounted on the front of the bus by squeezing the release handle and lowering the rack.
For safety reasons, coach operators cannot get off the bus to assist you in the loading or unloading of your bicycle. Bicycles are not allowed inside the bus.
Lift your bike onto the rack, fitting wheels into the slots. The racks are designed to accommodate standard two wheeled, single seat bicycles. Your bike must fit securely into the rack to be transported.
Recumbent bikes, tandem bikes, three-wheeled bikes and motorized bikes are not allowed on bike racks, as they do not fit safely. We also recommend trying to sit near the front of the bus so you're able to watch your bike during the ride.
Raise and release the support arm over the top of the front tire. Make sure the support arm is resting on the tire, not the fender of the bike.
Please make sure you remove all loose or personal items from your bike, such as water bottles and bicycle pumps, before the bus arrives.
Children may use the rack when accompanied by an adult. Always wear a safety helmet when riding your bicycle. Bicycles are not allowed inside of the bus. Citilink is not responsible for loss or damages to or by bicycles on the transit system property. The bicycle rider is responsible for making sure the bike is properly secured before boarding the bus.
Download in our Rack-&-Roll guide.
Tell the driver you need to unload your bike as you approach your stop. Unload from the curbside of the bus. Lower the support arm and lift your bike out of the rack. Squeeze the release handle and fold up the rack, if there is no other bike. Make sure the rack locks into place. Return to the curb with your bike, where the bus driver can see you, and wait for the bus to leave. Do not cross in front of the bus.
Bike loading information courtesy of Indygo.net.
1, 2 Main/Columbia/Clay & St. Joe Blvd.
6, 9 Main & Thieme Dr.
4 Lakeside Park/Anthony Blvd. & Niagara Dr.
This information is also available for download in our Rack-&-Roll guide.
Using alternative transportation, such as bike & bus, just one day a week can save over $560 in total driving costs per year. The bus costs only $1.00 per ride and there is no extra charge to bring your bike.
Ride the bus one way and ride your bike the other. Extend your range and avoid areas not conducive to bicycling by riding the bus. Use this guide to Rivergreenway/bus route access points.
One car emits thousands of pounds of air pollution and uses an average of 550 gallons of gas every year. Bikes do not. Full buses mean fewer cars which also reduces traffic congestion. Fort Wayne's Clean Air Force encourages you to "do what you can do"!
You and your bike may board at any Citilink bus stop or safe intersection along our many routes. We recommend you familiarize yourself with our route maps and schedules. You may also call our customer service representatives at 432-4546 and they will help you identify the most convenient location and time to catch the bus. Please arrive at the stop 5-10 minutes early to ensure your connection.


text:
Q: TextFormField become non-editable after the set text on its controller I tried several ways to solve the problem. But still, I got some issues. The code below shows the exact implementation I did for my application. The idea is to make the textfieldform accept the user input and also set the data value which loads from the database. But, after I use the method like =>  itemPriceController.text = [databaseloadedvalue], the textfield becomes static where the user cannot edit/change the content set on the controller. The below code is for demo purposes only
class AddItemFromImage extends StatefulWidget {
  final String company, productName;
  final bool isImageInput;
  const AddItemFromImage(
      {Key? key,
      required this.company,
      required this.productName,
      required this.isImageInput})
      : super(key: key);

  @override
  State<AddItemFromImage> createState() => _AddItemFromImageState();
}

class _AddItemFromImageState extends State<AddItemFromImage> {
  TextEditingController itemNameController = TextEditingController();
  TextEditingController itemPriceController = TextEditingController();
  TextEditingController itemDiscountController = TextEditingController();
  TextEditingController totalItemCountController = TextEditingController();

  @override
  void dispose() {
    itemNameController.dispose();
    itemPriceController.dispose();
    itemDiscountController.dispose();
    totalItemCountController.dispose();
    super.dispose();
  }

  @override
  Widget build(BuildContext context) {
    itemNameController.text = "Viyasan Dev Muthusamy";
    return Scaffold(
      resizeToAvoidBottomInset: false,
      appBar: !widget.isImageInput
          ? AppBar(
              title: Text(
                "SampleCode Test",
                style: TextStyle(
                  fontWeight: FontWeight.bold,
                ),
              ),
            )
          : null,
      body: Container(
      child: Column(
        children: [
          SizedBox(height: 40.0),
          Padding(
            padding: EdgeInsets.all(6.0),
            child: Text(
              AppStringHolder.lblMsgImgItem,
              textAlign: TextAlign.center,
            ),
          ),
          SizedBox(height: 40.0),
          Padding(
            padding: EdgeInsets.all(10.0),
            child: TextFormField(
              onTap: () {},
              controller: itemNameController,
              keyboardType: TextInputType.text,
              onChanged: (value) => onChangedItemName(value),
              decoration: _commonInputStyle(Colors.blueGrey, Colors.blueGrey,
                  AppStringHolder.lblItemName, false),
            ),
          ),
          SizedBox(height: 60.0),
        ],
      ),
    );
  }

}

A: Add this line in your init state ;

example:
 @override
  void initState() {
    itemNameController.text = "Viyasan Dev Muthusamy";

    super.initState();
  }

Your Problem will be solved

redpajama_set_name: RedPajamaStackExchange


The NF Network would like to congratulate the Gilbert Family Foundation on launching its Vision Restoration Initiative.
The NF Hope Concert hits the Windy City once again!
Dr. Frank Buono of @YalePsych has been awarded a 3-year grant to evaluate whether a mobile phone application can reduce pain in adults with NF1.


One objective has driven Craig Lockman since the day his daughter arrived on his doorstep--protect her at all costs.
But now he works for a new Agency with a leader who insists Jessie is the Chosen One, prophesized to bring about The Return and send all supernaturals back to wherever they came from. He will stop at nothing to see it realized.
Meanwhile, still enraged over the loss of her sister, Teresa Stevenson sees Jessie as a dangerous monster who must die, and Teresa will suffer a frightening sacrifice to make it happen.
But everyone has forgotten one small detail--if anyone wants to get to Jessie, they'll have to get through Lockman first, and he won't make it easy.


Hebrides Flat is situated above 'The Island Café' in Arinagour with beautiful views over Loch Eatharna. The flat is suitable for up to 7 with 3 bedrooms comprising one double a triple (one double and one single bed) and a further room with adult-sized bunkbeds and a cot. Both the double and the bunk room have sea views. The living room and dining area make a great social space for families, with a long table and benches (hand-made on Coll) which can seat 10 comfortably. The lounge overlooks the bay and has plenty of comfy seats, a flat screen tv, dvd player and wifi. There is also a large stock of books, games and playing cards to keep you entertained. The kitchen is fully equipped with a fridge, freezer, microwave, toaster, slow cooker, washing machine, tumble dryer and a dishwasher. Towels and bedding are provided. The bathroom has a bath, toilet and sink. A shower will be fitted in September 2016 when the flat will undergo a refurbishment. We hope you will find everything you need in the flat but if anything comes to mind during your stay please let us know. The Flat will be ready by 4pm on your day of arrival and we ask that you leave by 10am on the day of departure. Between these two times the flat will be set up for the next occupants.
If you are arriving early in the day then we will do our best to have the flat ready as early as possible. In any case, there are several places to visit in the village including An Cridhe, the fantastic community centre and arts venue where there is a weekly market from Easter to October selling local crafts and home baking. Also in the village are The Island Café, An Acarsaid Gift Shop, The Art Den and The Coll Hotel.
The Island Cafe is just below the flat and opens at 11.00am, serving fabulous coffee, teas, soft drinks, Scottish beers, wines, pastries, and lunch – sandwiches, soups and savoury meals. The Coll Hotel is open for lunches from midday until 2pm and again for evening meals in The Gannet restaurant.
While in the village or An Cridhe look for notices of events as there is always something going on and a Ceilidh could quite well be happening that very night! An Cridhe has a playing field and indoor sports hall suitable for badminton, table-tennis, netball, indoor hockey and football. There is also a well-equipped gym costing £4 per session. For details, see www.ancridhe.com.
We do hope you'll enjoy your visit to Coll and make the most of your stay. If there's anything we can do to help then please let us know and we'll do our best.
Finally, it is worth remembering to book your car onto the ferry at the earliest opportunity as it often gets booked up in the summer. Foot passengers and cyclists don't need to book in advance. If you are arriving on foot or by bike then please let us know and we'll arrange for you to drop off your bags whilst the flat is being cleaned in preparation for your arrival.
The Flat is situated above 'The Island Café' which offers lunches, evening meals, takeaways and Sunday roasts (which we thoroughly recommend!).
Next to The Island Cafe is the Shop, T.E.S.Co, (The Ethical Sales Co.) This shop, designed to complement 'The Island Stores', stocks all manner of flours, herbs, spices, delicatessen style cooking ingredients, world cheeses, charcuterie and ready to bake artisan breads just for starters, then there are housewares, haberdashery and craft work items, wild bird seed, wines and beers, soft drinks and fruit juices to name but a few more! GF items are also stocked and other special dietary items.
Enquiries and orders for the shop and Café can be made before arrival on Coll on [email protected] or 01879 230488 (or Cafe 230262).
T.E.S.Co is OPEN 6 days. And when the Café is open, evenings and Sundays.
The Cafe is open Monday, Thursday, Friday and Saturday from 11am to 2pm and 5pm to 9pm. It is also open on Sundays from 12pm to 6pm.
Bikes can be hired from the local Post Office, right on your doorstep. Kayaks can be hired for use around the bay from Carol Flett, in the village.
The Hebrides Flat is let on a weekly basis all-year round.


This hair is very soft and very manageable. I absolutely love it! The only thing I do to it in the morning is brush it and go because it already has a wave to it. The shipping was very fast. I ordered it Thursday and received it Tuesday.
The hair is so soft. I already know that it'll last for a long time because they have very great products!
I placed my order on a Monday and was expected to receive it on a Thursday ups had some delivery difficulty and delayed the order until Saturday which had me freak out but the vendor was very honest and very helpful she actually kept me calm each time I messaged the vendor for an update for the order she responded quickly and she kept me updated on the ordering process I received the hair and my god I couldn't be more satisfied and I was ok with the hair but this hair is true to length, no smell, didn't stredd, and it was very very very soft !! I'm installing my hair sunday and I can not wait if you don't order from her you're missing out best hair ever!!


The effect of introducing lateral substituents in liquid crystalline poly[(trimethylene)terephthaloyl-bis-4- oxybenzoate] has been analysed. The 2,2-dimethyl derivative has been synthesized and has shown liquid crystalline behaviour. The temperature for the crystal-liquid crystal transition and the mesophase-isotropic transition have been considerably lowered with respect to the unsubstituted polymer. Such transitions have been characterized by X-ray, differential scanning calorimetry and optical microscopy and analysed as a function of the thermal treatment.
Effect of branched alkyl spacers in liquid crystalline poly[2,2-dimethyl(trimethylene)terephthaloyl-bis-4-oxybenzoate] / J. Lorente, C. Marco, M. A. Gbmez and J. G. Fatou* // Polymer. – 1992. – Vol 33. – P. 202-205.
Effect of branched alkyl spacers in liquid crystalline poly[2,2-dimethyl(trimethylene)terephthaloyl-bis-4-oxybenzoate] - Завантажити.


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All posts filed under: Things for Charity
Artifact Uprising Desktop Calendars
With the end of the year soon approaching, what better time to upgrade that calendar you got last year from your local dry cleaner? These elegant (and affordable) desktop photo calendars by Colorado-based Artifact Uprising can make a nice holiday gift for home or office desks. Made of solid walnut, the Walnut Desktop Photo Calendar (starting at $30) showcases a dozen of your favorite photos in a year-round display. It features a brass-coated clip and peg stand, making a modern statement. The Brass Easel & Calendar (starting at $55) combines a solid brass easel with premium quality papers with your favorite snapshots. The Wood Calendar (starting from $25) is handcrafted from reclaimed pine. Artifact Uprising partnered with the non-profit SKCAC — a group that provides jobs for adults with intellectual disabilities — on this design. Last but not least, the Solidwool Calendar (starting at $40) is made of a sustainable composite material made from British sheep fleece. Like the others, it features 12 sheets with custom images. All images courtesy of …
Things for Charity / Things for Decorating / Things for Telling Time / Things for the Office / Uncategorized
Two Brazilian Shoe Brands Collaborate with Iconic Designers
Move over Rem Koolhaas and Zaha Hadid. The shoe world is drawing more big-name designers to the footwear industry, starting with a collaboration between the famous Brazilian shoe brand Ipanema and the world-renowned designer Philippe Starck. Called Ipanema with STARCK, the Spring/Summer 2016 collection is a re-envisioning of the modern sandal. Offered in four distinct designs in 12 colors each, the collection is both modern, yet comfortable, qualities that do not always go hand-in-hand (or foot-in-foot?) when it comes to shoes. The sandals are made of 30% recycled materials and are 100% recyclable. To achieve Starck's designs, Ipanema adapted its industrial process to be more manual and artisanal, resulting in a production process employing a proprietary plastique injection technique. Available worldwide, the shoes range from $30-$40. Perhaps not to be outdone by their countrymen, another Brazilian footwear brand, Melissa Shoes, has collaborated with the furniture design duo the Campana Brothers. Inspired by their Baroque furniture collection, the Melissa Barroca x Campana collection are plastic flats that "lend a playful interpretation of Italian Baroque infused with the vibrancy of everyday Brazilian culture," according to the brand. In celebration of the latest designs, the Campana Brothers have launched an installation Barroca: The Harmony …
Things for Charity / Things for Feet / Things for Relaxing / Things for Wearing / Things that are Recycled
Dopper Reusable Water Bottle
Dopper founder and CEO Merijn Everaarts felt compelled to develop a new type of reusable water bottle after watching a documentary about the "Great Pacific Garbage Patch" that is roughly twice the size of the U.S. After holding a design competition to find the perfect reusable bottle for drinking water, Everaarts selected a design by Delft Univeristy of Technology alumnus Rinke van Remortel. The bottle comes apart to be easily cleaned and features a built-in cup that also doubles as a stand. The original version of the Cradle to Cradle-certified water bottle is made of polyproplyene (for the bottle and the cap), ABS plastic for the white cup, TPE for the sealing rings in the cap and the cup, and Bisphenol A, a plasticizer that may leach from its material and enter the food chain. A steel version of the bottle, which will be available in a few months, replaces the polypropylene with steel and does not contain any Bisphenol A. The bottle is produced in Holland with a net zero carbon footprint. 5% of …
Things for Charity / Things for Drinking / Things for Excersizing / Things for Health / Things for Human Rights / Things for the Planet
Press Uncuffed Bracelets
Hundreds of journalists around the world are currently imprisoned for nothing more than having the courage to report the facts. According to Dana Priest, the John S. and James L. Knight Chair in Public Affairs Journalism at the Philip Merrill College of Journalism at the University of Maryland, the last three years have been the worst on record for the safety of journalists covering news in many parts of the world. Ever wonder what you can do to help? Press Uncuffed, a campaign powered by students at the Phillip Merrill College of Journalism in partnership with the Committee to Protect Journalists, is helping to raise awareness of and help free imprisoned journalists by selling bracelets bearing their names. Available for $10 each on the Investigative Reporters and Editors online store, the cuff-like bracelets are made in Memphis, Tennessee with LuciteLux clear acrylic, a reminder of the importance of transparency of information. The Press Uncuffed bracelets honor nine journalists: Ammar Abdulrasool in Bahrain, Mahmoud Abou Zeid (Shawkan) in Egypt, Reeyot Alemu in Ethiopia, Khadija Ismayilova in Azerbaijan, Bheki Makhubu in Swaziland, Ta Phong Tan in Vietnam, Jason Rezaian in Iran, Yusuf …
Things for Charity / Things for Human Rights / Things for Wearing
AllSwell Notebook
The AllSwell Notebook is a slim, travel-friendly journal made in the U.S. from recycled materials. Launched by Laura Rubin, founder and creative director of Left Left Right (LLR) Consulting, the 8.5" x 6.5" notebook is essentially two journals in one, including a lined "WRITE" side and a unlined "DRAW" side perfect for sketching. A percentage of the proceeds will go to A Walk on Water, an organization that provides water therapy through guided surf instruction to specials needs children. The notebook has 96 blank pages: 48 lined and 48 unlined. The interior covers feature custom designs by illustrator Alessandra Olanow. $21.00. http://allswellcreative.com/pages/find-us All images courtesy of AllSwell Creative.
Things for Charity / Things for Drawing / Things for the Office / Things for Traveling / Things for Writing
Dream of Venice is a beautiful new book for Venetophiles and dreamers alike edited by JoAnn Locktov with photography by Charles Christopher, a New York native who currently works in Hollywood as a motion picture and TV still photographer. Printed on luxe Italian Garda Silk paper, the 96-page hardcover includes photographs by Christopher that have been carefully paired by Locktov with the words of writers, actors, poets, singers, and others who have fallen in love with this near-mythical city. I am one of them in fact. My poem Leaving Venice appears in the book alongside a forward by novelist Frances Mayes, and contributions by Woody Allen, opera soprano Sylvia Sass, and Venetian cookbook author Marcella Hazan, among others. I first visited Venice as a undergraduate in the early '90s with a group of Italian language students attending a three week mini-session during our winter break. It was my first trip out of the country and the longest I had ever been away from my family. It was January, a time when the city belongs to the Venetians rather than tourists. One misty afternoon I remember walking through a campo (a …
Things for Charity / Things for Reading


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Q: Naming abstract classes and Interfaces in TypeScript There are debates and no consistency in this question, so I want to clarify naming standards for class, file names, suffixes and others for typescript.
I want to know, how you name abstract classes, interfaces and logically organize code in your Typescript projects?
Possible solutions:
For interfaces:

*

*with "I" as a prefix

*with "Interface" as a suffix

*with nothing added at all

For abstract classes:

*

*with "Abstract" as prefix

*something like "Base" as a prefix

*with nothing at all

Example with C#
public class User : AbstractUser, IUser

Same in Java and PHP
public class User extends AbstractUser implements UserInterface

And in Typescript
export class User extends AbstractUser implements UserInterface

This is the normal approach used in frameworks based on languages such as C#, Java and modern PHP7+

Microsoft is recommending add "Interface" as a suffix, which for me is correct.
https://github.com/Microsoft/TypeScript-Handbook/blob/master/pages/Interfaces.md#class-types
Another popular style guide is suggesting not to add any suffixes for prefixes to interfaces, for me violates the rules, readability and overall looks wrong. https://basarat.gitbooks.io/typescript/content/docs/styleguide/styleguide.html#interface
export class User extends AbstractUser implements User

A: I think this is a matter of taste.
I'd use interface name User instead of IUser or UserInterface if a user object can be described by plain JSON, thus being a pure data object with no class-like behavior. Because you might never need an implementing class, you can always use object literals:
interface User {
    name: string;
    email: string;
}

function createDummyUser(): User {
    return {
        name : "Alice",
        email: "a@wonder.land"
    }
}

I'd use the plain name of the abstract class of objects (like 'Car') and use a specific name for the non-abstract class (like 'Beetle'). You can ensure your abstract implementation is not used by mistake by making the constructor protected:
class Car {
    protected constructor() {
    }
}

const fail = new Car();  // error because c'tor is protected

class Beetle extends Car {
       public constructor(){
           super();
       }
}

let itBe = new Beetle();  // here we go!

A: Our node app is demanding on interfaces a lot - they everywhere, we  do the type checking and type hinting, so meaningful names are super important for us.
import {MediaInterface} from 'app/models/mediaInterface';
import {ServerInterface} from 'app/server/serverInterface';
import {UserInterface} from 'app/models/userInterface';

export class MediaStorage extends AbstractStorage implements StorageInterface {

  /**
   * current user
   * @private
   */
  private user: UserInterface;

  /**
   * @constructor
   * @param {ServerInterface} app
   */
  constructor(private app: ServerInterface) {
    // ...
  }

  /**
   * @param {UserInterface} user
   * @returns {Promise<any>}
   */
  public deleteUserMedia(user: UserInterface): Promise<any> {
    // ...
  }

  /**
   * @param {object} req request
   * @param {object} res response
   * @returns {Promise<MediaInterface>}
   */
  public create(req: any, res: any): Promise<MediaInterface> {
     // ...
  }

}


What do Lotus flowers and Keystone Ridge Designs Schenley benches have in common? They both can be enjoyed throughout the summer at Echo Park Lake in Los Angeles, California. As one of the oldest and most beautiful parks in L.A., today's blog features this historic setting and our involvement in the major rehabilitation that has transformed the park.
In the late 1860s, the area was originally developed as a reservoir to accommodate rapid population growth in Los Angeles. In response to the city's need for more public parks, Joseph Henry Tomlinson, landscape architect and Superintendent of the Department of Parks, designed the reservoir area into a recreational park. Officially established in 1892, Echo Park Lake has seen many changes and additions throughout the years. Its rich history includes the construction of a boathouse in 1932, the installation of the Lady of the Lake statue in 1937 and the addition of the lake's prominent fountain prior to the city hosting the 1984 Olympic games – all of which still remain today. With the L.A. skyline as its backdrop, the park currently flourishes as a place to enjoy nature and find respite from the bustling city. Getting the park up to its current beautiful state, however, did not happen on its own.
In 2006, Echo Park Lake was identified by the State of California as an impaired water body. Around the same time, Los Angeles voters passed Proposition O, which authorized the city to fund projects that prevent and remove pollutants from waterways. Echo Park Lake was one of the projects to benefit from the Proposition O initiative. What started as a stormwater improvement project expanded into a multimillion-dollar rehabilitation to preserve the history of the park while creating a more sustainable and inviting destination. In 2011, Keystone Ridge Designs became involved in the site furniture selection process. While working with the landscape architect, Josh Segal (then of AECOM), our Schenley benches were chosen as an early favorite to provide the perfect balance of historic charm and modern design. With the addition of center arms on the benches, it encouraged proper usage and deterred vagrancy.
"As landscape architects, our goal was to respect the rich history of Echo Park Lake while balancing authenticity with sustainability, recreation, durability, and habitat. The Schenley bench helps evoke memories of an early 19th Century park bench, but does so in a clean and bold way."
The park was closed for two years to facilitate the renovations until it reopened in June of 2013. It was then that pedestrians found newly constructed wetlands, restored lotus plantings, educational signage, lighting, additional vegetation and our Schenley benches strategically placed throughout the new pathways. Our Reading litter receptacles were also incorporated and customized to accommodate extra-large trash capacity.
More recently, we worked with The Los Angeles Parks Foundation, a nonprofit raising private funds for LA's 450 city parks, to provide additional benches as well as coordinating Schenley table sets. Adding the new furnishings aids the Los Angeles Parks Foundation's mission to enhance, expand, preserve and promote public recreation, parks and open space for the people of Los Angeles.
One of our favorite things about this park is how often we catch a glimpse of our benches in the background of TV shows or commercials that have been filmed at Echo Park Lake. Between the proximity to the filming industry and the picturesque scenery, it can be an ideal filming location. Many of us at Keystone Ridge Designs have caught ourselves hitting the pause button to point out our Schenley with center arms in anything from cell phone ads to pharmaceutical spots.
Since the renovations, the park clearly continues to be a center of outdoor activity. With fishing, pedal boats, picnic areas, walking paths, festivals, and the iconic lotus blossoms that are in bloom June through August, you can always find something to enjoy at Echo Park Lake. But in our opinion, the best place to view it all is from a Keystone Ridge Designs bench.


We are working on defining a new brand name using the community process described here.
The Eclipse Yasson and EclipseLink projects have been transferred to EE4J, and are now part of the overall EE4J project.
We have created Eclipse Jersey and Eclipse Mojarra projects and are working on contributing sources for these.
You can watch (and star!) EE4J project repositories as they are being created in the EE4J GitHub organization.
Oracle is working on Eclipse project proposals for all of the technologies Mike mentions in his blog: JSON-B API, Concurrency, Security, JTA, JavaMail, JAX-B, JAX-WS, JSTL, UEL, JAF, Enterprise Management, and Common Annotations. We intend to formally propose these projects to the EE4J Project Management Committee (PMC) very soon. One of our major near-term goals is to transfer all of the Oracle-owned GlassFish technologies to EE4J such that we can build "Eclipse GlassFish" from EE4J sources and demonstrate Java EE 8 compliance.
We are working on establishing an Eclipse Foundation working group to provide a member-driven governance model for EE4J.
In short, there is a lot of positive progress being driven in the EE4J project. For further updates refer to this blog and the links provided above, or subscribe to the ee4j-community mailing list.
Originaly posted on The Aquarium blog.


Fine−tuned for functionality and speed the Larice Light Pants are for athletic, fast paced ski tours that feature a narrow cut and offer excellent mobility and breathability thanks to a clever mix of materials. The high stretch softshell fabric blocks out the wind yet is extremely breathable at the same time. Side ventilation zips provide an ideal microclimate, even during intensive exercise. Elastic leg cuffs with rugged Cordura® abrasion protection can be quickly and easily adjusted over your ski boots. Reflective elements provide greater safety during evening tours. The textile materials were produced from sustainable resources in accordance with the environmentally friendly bluesign® standard. This product features Eco Finish, a flourocarbon free (PFC−free) textile finish that provides environmentally friendly water repellency.