Neuron-glial antigen 2 (NG2), also known as chondroitin sulphate proteoglycan 4 (CSPG4), is a surface type I transmembrane core proteoglycan that is crucially involved in cell survival, migration and angiogenesis. NG2 is frequently used as a marker for the identification and characterization of certain cell types, but little is known about the mechanisms regulating its expression. In this review, we provide evidence that the regulation of NG2 expression underlies inflammation and hypoxia and is mediated by methyltransferases, transcription factors, including Sp1, paired box (Pax) 3 and Egr-1, and the microRNA miR129-2. These regulatory factors crucially determine NG2-mediated cellular processes such as glial scar formation in the central nervous system (CNS) or tumor growth and metastasis. Therefore, they are potential targets for the establishment of novel NG2-based therapeutic strategies in the treatment of CNS injuries, cancer and other conditions of these types.
In the last 40 years, many studies have analyzed the structure and functions of neuron-glial antigen 2 (NG2), which is also known as chondroitin sulphate proteoglycan 4 (CSPG4), high molecular weight melanoma-associated antigen (HMW-MAA) or melanoma chondroitin sulfate proteoglycan (MCSP) [1–4]. The NG2 or CSPG4 gene encodes a surface type I transmembrane core protein of ~300 kDa . The extracellular N-terminal domain of this protein is post-translationally modified by chondroitin sulfate glycosaminoglycan chains and disulfide bonds. It also contains putative proteolytic cleavage sites . The function of the extracellular domain fragments is still widely unknown. However, a growing body of evidence suggests that they are involved in the regulation of neuronal networks  or endothelial and pericyte functions . The intracellular C-terminal domain of NG2 acts as an acceptor site for the extracellular signal-regulated kinases (ERK) 1/2 and protein kinase C-alpha (PKC-α) as well as a binding site for multi-PZD domain protein 1 (MUPP-1). These interactions activate key signaling pathways involved in cell migration, cell survival and angiogenesis [9, 10].
NG2-mediated signaling has been shown to play an important role in the progression of several tumor types. For instance, elevated NG2 expression is predominantly found in glioblastoma and this correlates with a poor prognosis due to increased NG2-mediated chemo- and radioresistance of the tumor cells [11, 12]. In addition, NG2 serves as a key intermediate of tumor cells with extracellular matrix molecules and thus crucially determines metastatic formation in soft-tissue sarcoma and melanoma patients [13, 14]. Accordingly, NG2 is a promising target for the development of novel tumor therapies [15–17].
NG2 is also expressed in certain benign cell types. In particular, high levels are detected in NG2-glia of the central nervous system (CNS) [18, 19]. NG2-glia are non-neuronal, non-vascular cells that underlie a complex interplay of epigenetic mechanisms and transcription factors in distinct developmental stages [20, 21]. They are sometimes called polydendrocytes because of their branched morphology or oligodendrocyte precursor cells (OPCs) due to their contribution to the renewal and maintenance of the oligodendrocyte population [22, 23]. Mesenchymal stem cells, osteoblasts, melanocytes, smooth muscle cells and macrophages have also been shown to express NG2 [3, 24, 25]. Finally, the proteoglycan is a typical marker for vessel-surrounding pericytes, which contribute to the stabilization of microvessels, the regulation of capillary blood flow and angiogenesis . Interestingly, the expression pattern of NG2 markedly differs between distinct pericytes depending on the type of analyzed tissue. For instance, only arteriolar but not venular pericytes are positive for NG2 in the mesenteric microvascular network [27, 28]. By contrast, the proteoglycan is expressed in pericytes of all of the microvascular segments in the retina: arterioles, capillaries and venules .
These findings indicate that the expression of NG2 underlies a finely balanced regulation dependent on specific cell functions in different tissues. However, which factors are involved in this regulation and how they interact with each other remains elusive. As outlined in the following review, NG2 expression is influenced by inflammation and hypoxia and is intracellularly regulated by methyltransferases, transcription factors and miRNAs (Table 1).
Different NG2-positive cell types in the CNS express receptors for inflammatory cytokines [30–32]. Studies indicate that these cytokines are directly involved in the regulation of NG2 expression and function in response to CNS injuries. For instance, disruption of the blood–brain barrier has been shown to stimulate the release of tumor necrosis factor-alpha (TNF-α), interleukin 1-alpha (IL-1α) and interferon-gamma (IFN-γ) from platelets and other blood components, resulting in increased NG2 levels in OPCs . Gao et al.  further detected a higher mRNA and protein level of NG2 in microglial cells following stimulation with lipopolysaccharide (LPS). This was associated with a higher expression of inducible nitric oxide synthase (iNOS), IL-1β and TNF-α, which could be reversed by treatment with NG2 siRNA. In addition, neuroinflammatory disorders, such as autoimmune encephalomyelitis, elevate the expression of NG2 in OPCs, macrophages and CNS-resident microglia, which is mediated by transforming growth factor-beta (TGF-β) [35, 36]. Inhibition of TFG-β activity by decorin [37, 38] or TGF-β1 receptor signaling by SB525334 attenuates this TGF-β-induced NG2 expression .
Taken together, these studies indicate that cytokine-mediated NG2 expression is a major response mechanism to various destructive processes in the CNS. In this context, it should be considered that NG2 is an important contributor to glial scar formation , during which increased expression levels of extracellular matrix components and chondroitin sulfate proteoglycans, including NG2, form an inhibitory barrier to regenerating axons, blocking their outgrowth in the surrounding tissue [41, 42]. Accordingly, the modulation of this process may be a promising approach to promote neuronal repair after traumatic or inflammation-induced CNS injuries.
In addition, van Sinderen et al.  recently analyzed the role of NG2 in the placenta and extravillous trophoblasts. They found that IL-11 and leukemia inhibitory factor (LIF), known to be produced by the placenta in the first trimester [44, 45], stimulate NG2 expression specifically in the placental villi and deciduas. They speculated that these two cytokines stimulate the early differentiation of the cytotrophoblast cells towards the migratory extravillous trophoblast phenotype via the upregulation of NG2 levels.
Several studies show that NG2 expression may be regulated by hypoxia-induced signal transduction. Under normoxic conditions, NG2 expression is only found in pericytes located along the arterioles and capillaries but not along the venules of adult rat mesenteric microvascular networks . Exposure of these networks to chronic hypoxia is associated with additional expression of the proteoglycan in venular pericytes . This indicates an important function of NG2 in these activated cells during hypoxia-induced angiogenesis and vascular remodeling . Concurrent with this view, Ozerdem et al.  found a substantially reduced neovascularization in the ischemic retinas of NG2 knockout mice when compared to wild-type controls.
Hypoxia-inducible factors (HIFs) are the most important transcription factors mediating hypoxic expression of target genes . Accordingly, they may also be involved in the regulation of NG2. Under normoxia, HIFs are constitutively expressed in the cytoplasm with a very short half-life, because they are hydroxylated. This promotes their binding to von Hippel-Lindau protein (VHL), which targets HIFs for rapid proteasomal degradation. Under hypoxia, non-hydroxylated HIFs translocate to the nucleus, resulting in increased target gene expression . Concurrent with these findings, Keleg et al.  could demonstrate that NG2 mRNA and protein levels are already overexpressed in the normoxic pancreatic cancer cell lines Panc1 and HS766T, which exhibit mutations of VHL. Exposure of these cells to chronic hypoxia further enhances these high NG2 mRNA and protein expression levels.
DNA methylation has recently been identified as a major epigenetic mechanism for the regulation of gene expression . It is characterized by the transfer of a methyl group to the 5' cytosine of a CpG dinucleotide by DNA methyltransferases, resulting in the suppression of gene transcription . Promoter methylation of tumor suppressor genes is particularly found during carcinogenesis, indicating that this process induces the development of many types of tumor [53–55]. Interestingly, Luo et al.  found that the promoter of the NG2 gene also contains many 5'CpG methylation sites. It has further been demonstrated that reduced methylation of this promoter increases the expression of NG2 in melanoma cell lines, primary melanoma lesions, and head and neck squamous cell carcinoma [56, 57]. Since high NG2 expression is often associated with elevated multi-drug resistance [11, 12, 58], methylation of the NG2 promoter may thus determine the therapy response and prognosis of many cancer types.
In addition to DNA methylation, NG2 expression is also regulated by several transcription factors. In 2009, Sellers et al.  described the regulatory region (1585 bp) upstream of the mouse NG2 coding sequence in detail. The TATA-box of the NG2 promoter is 1299 bp upstream of the transcriptional start. Putative binding sites for transcription factors are located within this region. As identified by Transcriptional Element System Search (TESS), these transcription factors may include C/EBP, p300, CBP and Sp1. The latter seems to have a particularly crucial role in the regulation of NG2 gene expression. Sellers et al.  showed that transfection of COS cells with luciferase reporter gene constructs that contain the NG2 promoter without a TATA-box and the upstream located Sp1 binding sites, results in increased cellular luciferase activity. On the other hand, Leung et al.  found that silencing Sp1 downregulates the transcription of the proteoglycan in keratinocytes. These contradictory findings suggest that additional post-transcriptional modifications of the constitutively expressed transcription factor Sp1 determine its function as a transcriptional activator or repressor of NG2 .
Paired box 3 (Pax 3) is another transcription factor capable of influencing target gene transcription in a positive  or negative  manner. However, Pax3 has only been shown to increase the expression of NG2 in melanocytes . Pax3 silencing results in a diminished expression of the proteoglycan in these cells . It has further been reported that TGF-β suppresses the expression of Pax3 in melanocytes via a smad-dependent pathway . Since this growth factor upregulates NG2 levels in CNS-resident microglia [35, 36, 39], this finding indicates that other transcription factors must be involved in TGF-β-induced NG2 expression or that its regulation markedly differs between individual cell types.
The transcription factor Egr-1 is a crucial mediator in ERK-dependent signaling during cell survival, apoptosis and differentiation . ERK phosphorylates and activates the transcription factor Elk-1 [68, 69], which increases the expression of Egr-1 . Egr-1 regulates the expression of different genes encoding for adhesion proteins and cytokines . Beck et al.  demonstrated that after cerebral ischemia, reactive astrocytes exhibit high levels of Egr-1. Silencing Egr-1 in these cells diminished the expression of genes that are important for glial scar formation, including NG2. They concluded that this transcription factor may represent a potential target for the modulation of neuronal tissue repair and regeneration.
In the last decade, microRNAs (miRNAs) have been identified as novel, powerful regulators of protein expression. They are endogenously expressed small non-coding RNA molecules that suppress protein expression by interacting with the target messenger RNA (mRNA) . miR129-2 belongs to the group of tumor suppressor miRNAs, because its transcription is downregulated in some types of cancer due to increased methylation . It was recently reported that overexpression of miR129-2 decreases NG2 levels in diffuse intrinsic pontine gliomas . miR129-2 also suppresses the expression of platelet-derived growth factor receptor-alpha (PDGFR-α) in glioma cells . This receptor stimulates the proliferation of various mesenchymal and glial cells and is one of the most amplified genes in glioblastoma . In addition, interaction of NG2 with PDGFR-α has been shown to promote cell proliferation in response to PDGF [76, 77]. These findings suggest that miR129-2 may represent a promising candidate for NG2-targeting tumor therapy.
Although NG2 is important for cell function and frequently used as a marker for the characterization and identification of certain cell types, there is little knowledge about the mechanisms that regulate the expression of this proteoglycan. The reports discussed here provide the first evidence that this regulation underlies inflammation and hypoxia and is mediated by methyltransferases, transcription factors and miRNAs (Fig. 1). In the future, the identification of additional regulatory factors may further improve our understanding of NG2-mediated cellular functions, such as cell survival, migration and angiogenesis. In addition, it may also contribute to the establishment of NG2 as a novel therapeutic target in the treatment of CNS injuries, cancer and other conditions.
EA reviewed the literature and wrote the manuscript. BMS was a contributor in reviewing the literature. MDM and MWL revised the manuscript. All authors read and approved the final manuscript.


A unified league of heroes devoted to championing truth, justice and freedom for all people. The Justice League was formed in the wake of the battle against the Monitors, by seven former members of the Watchtower Network: Superman, Green Arrow, Martian Manhunter, Batman, Red Tornado, Wonder Woman and Green Lantern.
During the sixth season, there were plans for a Justice League spin-off. The show would've had Oliver Queen give refuge to young metahumans, while putting together a team and trying to help them out.


Council Member Thom Miller has served as at large B council member since 2016. Born and raised in East St. Paul, Miller and his family were drawn to St. Louis Park in 2000 for numerous reasons, including the neighborhood associations, great schools and diverse population. He joined the Birchwood Neighborhood Association right away and served as block captain for many years.
Always interested in public policy, Miller helped to found Safety in the Park, a grassroots organization that worked to prevent the rerouting of heavy freight trains to St. Louis Park. He enjoyed working with numerous St. Louis Park residents in their successful nearly five-year effort, and eventually decided to continue his community efforts by running for city council.
A graduate of the University of Minnesota – Twin Cities, Miller works as a national sales director for a global housewares product-design company. In his free time, Miller spends time with his wife and children, volunteers at his church, mountain bikes, plays the drums, and loves hanging out with his Birchwood neighbors.


Mailpile has existed as an app within Freedombone for a couple of years, and it's a nice webmail client, but for a more mass market type of approach it's not ideal. The reason is that the setup is quite non-intuitive and assumes that you know what acronyms like SMTP, IMAP and GPG mean. It's highly doubtful that the average shopper knows about any of that, and chances are they just use Gmail because that's what they were instructed to do by the initial setup process when they first got an Android phone. Gmail didn't ask them for an IMAP domain.
So I added a customized version of squirrelmail to the web interface of Freedombone.
The login has been changed to a new logo, and it's linked up to themes and languages such that if you change that on the settings screen the webmail system also changes accordingly. Testing it on mobile in the vertical orientation it looks odd but in horizontal orientation its ok and quite usable. I made a couple of themes called freedom_light and freedom_dark using the same colors as the main web interface so that it looks somewhat consistent. And you can use it to send between onion or clearnet email addresses without much hassle.
So despite its age and smartphone agnosticism Squirrelmail still appears to be quite a good addition.
Apart from the usual advantages of onion addresses the biggest one here is that you don't need to be using GPG to still have fairly good communications security. It's not end-to-end in the strictest sense, but a lot more secure than email usually is. You can also use it via a Tor browser with the security level cranked up to the max if you want to.


text:
19-year-old driver shears hydrant, arrested on suspicion of DUI
Caleb Lunetta
The Santa Clarita Valley Sheriff's Station
After a man allegedly drove over a fire hydrant Friday night, deputies arrested him on suspicion of DUI-related charges.
Andrew Larochelle, 19, crashed into a fire hydrant in an SUV around 11:30 p.m. at Valencia Boulevard and McBean Parkway, according to Santa Clarita Valley Sheriff's Station officials.
"All the information came through (LASD)," said Los Angeles County Fire Department Supervisor Melinda Choi. "It was a traffic collision involving a hydrant."
As the flooding continued in the area, officials reportedly worked to temporarily shut down McBean as they attempted to shut off the spouting water.
"Deputies did arrest a 19-year-old male driver, Andrew Larochelle, around 11:30 p.m. last night for DUI," Shirley Miller, spokeswoman for the Santa Clarita Valley Sheriff's Station, said Saturday.
Larochelle was booked at 1:45 a.m. on Saturday at the SCV Sheriff's Station and held in lieu of $15,000 bail.
Fire officials were on the scene until approximately midnight, working to shut off the water, according to Choi.
Caleb Lunetta covers government, criminal justice, education and breaking news for The Signal. He joined in Nov. 2018 and previously worked as a supply chain engineer in Veterans Affairs hospitals. He is a graduate of Cal State University, Northridge and a proud College of the Canyons Model United Nations alumnus. Have a story tip? Message him on Twitter (@lunettcaleb) or at [email protected]

redpajama_set_name: RedPajamaCommonCrawl


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text:
Livestream/On-Demand
Our Ancient Celestial Origins and Destiny
When the Morning Stars Sang Together
Join us online for this on-demand conference session featuring John Van Auken on Our Celestial Origins.
We are literally "children of the stars"—we're made of stardust! And according to Cayce, the stars were made for us. John Van Auken explores Our Celestial Origins in this online presentation originally taped at our annual Ancient Mysteries Conference.
Approximate run time: 1 hour, 14 minutes
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Watch from the convenience and comfort of your own home via desktop computer, laptop, tablet, or even your smart phone, and enjoy this special presentation on-demand at your convenience any time.
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John Van Auken
John Van Auken is an internationally renowned speaker, a long-time A.R.E. staff member, a current director at A.R.E, and a popular leader of A.R.E.'s tours to sacred sites around the world. He is the author of numerous bestselling books including Edgar Cayce on the Spiritual Forces Within You, Angels, Fairies, Demons, & the Elementals, and is co-author of his most recent, Edgar Cayce on the Mysterious Essenes: Lessons from Our Sacred Past. His extensive knowledge of the Edgar Cayce readings, the Bible, ancient Egypt mysticism, world religions, and Christ Consciousness make him a popular and authoritative teacher.
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text:
SFUSD's Mission of Educational Equity and Excellence
San Francisco is a hotbed of innovation, technology, and startups – a land of seemingly never-ending opportunity. Within the city depicted on TV shows and in magazines sits a school district that is one of the most diverse in the nation, and faces some of the most persistent opportunity gaps.
In San Francisco Unified School District (SFUSD), education is a social justice issue. For more than a decade, SFUSD has focused relentlessly on surfacing equity and the role that systemic oppression plays in the education landscape.
SFUSD is a relatively small district when compared to other major urban centers. It has about 55,000 students, in nearly 140 schools (compare that to New York City, the largest in the country, with 1.1 million students). The student body is comprised of:
● 35% Asian
● 27% Latino
● 14% White
● 7% African American
● 4% Filipino
● 4% Multiracial
● 24% English Language Learners
Despite the District's small size and willingness to openly address equity and access, San Francisco remains a place where race too often dictates a child's chance for success.
District data from 2016-2017 show that 74 percent of African American students, 61 percent of Latino students, and 65 percent of Pacific Islander students did not meet state assessment standards in at least one subject area. But for white and Asian students, those numbers shrink to 14 percent 16 percent respectively.
Students watch their neighborhoods continue to change, as housing prices drive out families and young people move in. Students also notice the changes in their schools: because of teacher turnover, the District hires over 700 new teachers each year (with a total teacher force of 3,600). Schools with higher percentages of students from low-income communities face much higher rates of teacher turnover.
"Students are aware of the haves and the have-nots," said Jennifer Steiner, director of the Office of Professional Learning and Leadership at SFUSD and the primary liaison with NYU Steinhardt's Teacher Residency Program. "At the same time, they're also aware of what San Francisco has to offer – they see the tech companies outside their doors. They know there's real opportunity."
The situation is urgent and the gaps are far-reaching. But this is not viewed as an impossible challenge. In fact, it's quite the opposite. Steiner speaks optimistically: "We are located in the epicenter of technological advancement. We can create the next Google executives, and the next generation of folks who are our presidents and entrepreneurs. We have the tools to change this."
The new superintendent, Dr. Vincent Mathews, has a laser-like focus on interrupting the legacy of underserving marginalized populations. Though it's not just top down; everyone at SFUSD works to close the gaps. "We must believe, as educators, that we can change the narrative," says Steiner. "This is not about saving kids. We want educators who believe that our kids are the next generation of scholars, leaders, and change-makers."
This starts with a clear district-wide definition of systemic oppression and equity, combined with supports for all teachers. Every new teacher is given the opportunity to examine their biases and understand how these impact their viewpoints. "We're coaching each other and learning together as adults, all in service of supporting students."
From innovative methods of instruction, to building student agency and capacity to lead, to forming true partnerships with historically underserved communities, SFUSD is undeniably one of the most exciting places to become an educator. There's an opportunity to make real and lasting change.
"If you're the kind of person who wants to work in an urban environment where everyone believes that those who need more, get more – the students who need more time, get more time; the schools that need more resources, get more resources – then SFUSD is for you," Steiner says with every ounce of conviction.
Learn how NYU Steinhardt's Teacher Residency prepares you to become a teacher in high-need urban areas like San Francisco.
Tags: California, Diversity and Equity, San Francisco


text:
Prof. Mrs. Achike Anthonia Ifeyinwa.
anthonia.achike@unn.edu.ng
Anthonia Ifeyinwa Achike is a Professor of Agricultural Economics at the University of Nigeria, Nsukka. She holds a doctorate (PhD) in Agricultural and natural Resources Economics, and specialized in Agricultural Finance and Project Analysis. Professor Achike has attended several training courses on quantitative and qualitative techniques of analysis, gender, poverty, policy and other key development issues organized by different organizations. In particular, she has received training at the CODESRIA Gender Institute, Dakar-Sengal, and the Social Science Academy of Nigeria Gender Institute. She was trained on Time Series Econometrics and Game Theory techniques by the African Economic Research Consortium (AERC) network. Furthermore, she was trained on Poverty Mapping by the Poverty and Economic Policy (PEP) network in Manila, Philippines. Professor Achike has served as Consultant and Trainer in many gender evaluation projects, mainstreaming and training activities at both local and international levels. She has also conducted baseline studies for many local and international organizations.
Currently, she is holding the following positions: Director, African Climate Change Adaptation Initiative (ACCAI) at the University of Nigeria, Nsukka; Team Leader, Community Based Poverty Monitoring System (CBMS), Nigeria; Coordinator, Agribusiness Development programme of the African Network for Agriculture, Agro forestry and Natural Resources Education (ANAFE); and Coordinator, Climate Change Project of the African Women in Science and Technology (AWFST), a programme of the African Technology Policy Studies (ATPS).
Professor Achike has many publications to her credit comprising journal articles, book chapters, conference proceedings, training manual and technical reports. She is a member of many local and international professional bodies as well as Associate Fellow of the African Institute for Applied Economics. Professor Achike was the Head of Department of Agricultural Economics, University of Nigeria, Nsukka (2005-2007), and also a global faculty member of the trade policy training in Africa (trapca). She has won many competitive local and international research grants and has successfully completed them. At present, she is Consultant for a rice value-chain and aflasafe marketing studies in Nigeria as well as for an institutionally affiliated agribusiness project of the University of Nigeria, Nsukka, both of which are still on-going.
Professor Achike is conversant with the terrain of rural Nigeria where she has carried out studies on gender, conflict, value chain, agribusiness, poverty, etc in almost all the geopolitical zones.


text:
en - English (Selected)
Document stages in plenary
Select a document : Select...RC-B6-0209/2007B6-0209/2007B6-0213/2007B6-0222/2007B6-0230/2007
Texts tabled :
CRE 24/05/2007 - 14.4
Texts adopted :
Thursday, 24 May 2007 - Strasbourg
14.4. The situation concerning the President of the World Bank
Motions for resolution B6-0209/2007, B6-0213/2007, B6-0222/2007 and B6-0230/2007
The following spoke: Bernd Posselt, on behalf of the PPE-DE Group, who objected to the fact that a fourth debate on human rights, democracy and the rule of law had been included on the agenda, which he believed to be in contravention of the Rules of Procedure. He asked for the debate in question to be withdrawn from the agenda (the President replied that he would pass on Mr Posselt's remarks to the President of Parliament). John Bowis, Marios Matsakis, Pervenche Berès and Michael Gahler all spoke on Mr Posselt's request (the President reminded the House of the relevant provisions within the Rules and pointed out that the agenda of the House had been set on Monday with no objections). Bernd Posselt repeated his request (the President read out Rule 170(1)(2) and noted that no requests for adjournment of the debate had been made within the set deadlines).
Erik Meijer, Pervenche Berès, Marios Matsakis and Monica Frassoni introduced motions for resolutions.
The following spoke: Karin Scheele, on behalf of the PSE Group, Gerard Batten, on behalf of the IND/DEM Group, and Dalia Grybauskaitė (Member of the Commission).
The President returned to the subject of the controversy caused by the inclusion of the fourth debate on the agenda and stated he would refer the matter to the President of Parliament in order to prevent such a problem from happening again in future.
The debate closed.
Vote: Minutes of 24.05.2007, Item 15.4.


text:
Q: Error PHPMailer Hola a todos como están tengo un problema que según la documentación de la librería esta bien mi código
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  SMTP connect() failed. https://github.com/PHPMailer/PHPMailer/wiki/Troubleshooting
  ErroSMTP connect() failed. https://github.com/PHPMailer/PHPMailer/wiki/Troubleshooting

Segun vi su documentación del error todo esta bien pero no se donde este haciendo mal o tal vez me falte algo Gracias por la ayuda :)

A: Pueden ser varias causas para este problema

SMTP ERROR: Failed to connect to server: php_network_getaddresses:
  getaddrinfo failed: Temporary failure in name resolution (0) SMTP
  connect() failed.

Asegura que exista el SMTP, en ocasiones en el servidor donde tienes tu archivos php no se puede estar leyendo:
smtp.gmail.com

y que las credenciales son validas
 $mail->Username = 'fortel.luis.cunza@gmail.com';
 $mail->Password = 'xxxxxxx';

También verifica que el puerto no este bloqueado:
$mail->Port = 587;

A: Quita la linea comentada:
$mail = New PHPMailer;

// $mail->isSMTP();

$mail->SMTPDebug = 4;
$mail->Debugoutput = 'html';
$mail->SMTPAuth = TRUE;

Y prueba de agregar:
require 'class.smtp.php';

Si está en desarrollo y corriendo un servidor en local, como Xampp, lo mejor es comentar esa línea. En producción (y todo subido a un servidor comercial), se debe descomentar.
Google es impredecible. Y también entrar en la cuenta de gmail y habilitar la opción de permitir aplicaciones menos seguras:
https://support.google.com/accounts/answer/6010255?hl=es
Y por supuesto, si corre Xampp configurar correctamente Mercury, y encenderlo, o no saldrá ningún email. Una guía rápida, en Youtube:
https://www.youtube.com/watch?v=iwjNIUuM_iI&t=303s

A: Pues el error fue otro tuve que deshabilitar el selinux que fue quien estaba bloqueando la salida claro que esto lo hice en mi servidor donde se encuentra mi aplicacion muchas Gracias a todos

redpajama_set_name: RedPajamaStackExchange


She got them dread hands!! She took really great care of my dreads with great care. I wish she was closer so I can make it a dread affair!!!...Vernester S.
She's the best at what she does ! .....Oral G.
"FRIENDLY, PROFESSIONAL,BEAUTIFUL WORK! SHE'S JUST AS BEAUTIFUL A PERSON&SOUL. I STARTED COMING TO HER BY A FRIENDS RECOMMEDATION AND WILL RECOMMEND HER FORWARD".
"I LOVE MY BACK TO NATURAL TRANSITION,FAST AND EASY AND GORGEOUS! I'LL BE BACK"
"THANK YOU PERFECT AS ALWAYS"


text:
Home Travel & Tourism What to Eat When You're in Singapore
What to Eat When You're in Singapore
[Source: Pixabay]
For the foodie, exploring a new place isn't just an experience you can see, hear and touch, it's an experience you can taste. It's the sort of thing you employ all of your senses to enjoy – even if you're just using them to hunt down the nearest restaurant!
If you're landing in Singapore though, you're in for a treat, because the city-state nation is a riot of culinary experiences, covering everything from traditional Singaporean rustic dining to outrageously refined, colorful desserts. Food is so loved in Singapore that it's actually a national pastime.
We think that Singapore's dining is worth making the trip, and that's without getting into the world-class culture, nightlife and architecture on offer within the country. However, today we're going to focus on the food and bring you a handful of dining options for those indecisive souls with hungry bellies. Here's what to eat whilst you're in Singapore:
Singapore boasts an extremely multicultural population made up of ethnic Chinese, Indians, and Malays joined by Thais and many westerners, but it's the traditional local food that you can't afford to miss when you're in the country.
Consisting primarily of rice and meat dishes but with a huge variety of flavors on show, Singaporean dining is a communal, open and, often, very affordable way to spend an hour or two. For a perfect introduction to Singaporean cuisine, we can't think of a better first stop than the Old Airport Rd Food Centre, a pretention-free spot with cold beer and ultra-fresh and tasty local meals for low prices.
For a more upscale experience, why not try the National Kitchen by Violet Oon. Situated in astonishing décor and offering total refinement of some Singaporean dining classics, it's a fine choice – it's just a shame they don't deliver.
Travelling to Singapore to eat Thai food? It's not as crazy as it sounds. As noted here, Singapore is home to hundreds of Thai restaurants, largely started and staffed by Thai people who have settled in the country, marrying the iconic flavors of their birth country to the effortless dining culture of their adopted nation, with dishes like pad Thai becoming a staple.
In fact, Singapore's Thai food is regularly ranked as the best outside of its home nation, so checking it out whilst you're there is highly recommended. There are dozens of cheap Thai food joints found dotted throughout Singapore, but if you were pushing us for a favourite? Well, Sawadee might just have to take the crown (and don't miss the olive rice!)
Singapore has a sweet tooth, and it doesn't take long to find that out. Bakeries are a common sight and dedicated dessert parlors can be found all over the place, mixing in traditional Singaporean flavors with western desserts and local treats to create amazing experiences.
In fact, Singapore's café culture outstrips all of its neighboring nations, so whenever you find yourself hankering for something sweet, you'll find a local spot nearby with something for you. It's a fact that often surprises, but we'd never recommend leaving Singapore without digging into something filled with cream and wrapped in sweet, flaky pastry.
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A look at albums we have written about in 2013 – here's Lunasa and their 2013 release 'LÚNASA with the RTE CONCERT ORCHESTRA' taken from Irish Music Magazine.
Lúnasa have always been known for their innovativeness as a group and they have taken this skill to the next level with their latest collaboration with the national, classic treasure; the RTÉ Concert Orchestra. The Orchestra, under the guidance of their maestro David Brophy, have taken Niall Vallely's intricate arrangements and added an empathetic element to the traditional instrumental prowess of the Lúnasa stalwarts.
Take the Lecken Mór set which combines a beautiful choreography of wind instrumentals uplifted by the orchestral strings thereby creating a musical whirlwind of sound. This subsides into a backdrop for Smyth's perfect fiddling, building to a resounding orchestration on Vallely's title piece. Contrast this with the sombre introduction to the haunting pipes on An Buachaillín Bá, which is followed by a delicately picato string arrangement perfectly designed to welcome Crawford's hypnotic flute in Scully Casey's that drives into a fantastic version of The Dusty Miller.
The lift in the Lúnasa instrumentation as they glide gracefully into The Red Bee is fully enhanced by their orchestral counterparts as they reveal a fabulously dramatic ending to a magnificent tune. The drama continues into the final set where each and every instrument is undoubtedly used to full potential, culminating in a fabulous end to a fabulous album. An added bonus is that it's an enhanced CD so you get a peek of Lúnasa performing Morning Nightcap at the National Concert Hall, Dublin too.
Vallely produces sophisticated arrangements with an effortless flair and, his ability to understand the interaction of the instrumental genres, ignites a spark between Lú˙nasa and the RTÉ Concert Orchestra that is fully embodied in this album.
A stunning collaboration of musical work.


text:
Q: Is there a way to specify the installation location for composer? (PSR-4) I'm using composer to install my package and I'm trying to install my bundle in a very specific location.
In short, I have my packages with the following namespace prefixes:
TeamXyz/AbcBundle
TeamXyz/AbcComponent
Now, since we have tons of components and bundles, we want to separate them into 2 folders like this:
vendor/TeamXyz/Component/AbcComponent
vendor/TeamXyz/Bundle/AbcBundle
It used to work very well but with PSR-4 I cannot seem to be able to control the location where my package should be installed. I wonder if I have to write custom package installer for composer to be able to do this?

A: Ok, I found out a way to do that, simply wrote my own custom package installer and voila.
<?php
/**
 * Created by myTeam.
 * Date: 6/11/14
 * Time: 1:43 PM
 * Question? Come to our website at http://my.com
 * For the full copyright and license information, please view the LICENSE
 * file that was distributed with this source code.
 */

namespace My\PackageInstaller;

use Composer\Package\PackageInterface;
use Composer\Installer\LibraryInstaller;

class BundleInstaller extends LibraryInstaller
{
    /**
     * {@inheritDoc}
     */
    public function getPackageBasePath(PackageInterface $package)
    {
        $prefix = substr($package->getPrettyName(), 0, 3);
        if ('my/' !== $prefix) {
            throw new \InvalidArgumentException(
                'Unable to install package, my package '
                . 'should always start their package name with '
                . '"my/"'
            );
        }

        $packageName = str_replace('my/', '', $package->getPrettyName());

        return $this->vendorDir . '/my/Bundle/' . $packageName;
    }

    /**
     * {@inheritDoc}
     */
    public function supports($packageType)
    {
        return 'my-bundle' === $packageType;
    }
}

And yes I understand everything you guys complain about, but a tool is a tool and one person can use it the best way that fits his need. At least that's what I believe :). Maybe I'm doing something stupid here for not using Composer the exact way it was meant to be used. But hey, if we are using all the tools the exact ways they were meant to be used, lots of innovation would have happened in the first place :)


text:
Onus to recycle lies with USF and students
Resident students who want to recycle better have some spare time on their hands. The collection of separated waste from residence halls, instead of being the responsibility of USF, currently relies on the efforts of motivated students.
That's not to say that USF does not have a recycling program. The Tampa campus actually houses one of the last recycling centers in the city, located on Sycamore Drive. At this location, receptacles are provided for newspaper, glass and plastic. This is in addition to the sporadically sited aluminum and paper bins in buildings across campus.
Every Monday night, the aluminum and paper recycling bins are put out for collection. After a single compactor truck collects it in the morning, Dot Monroe, the program assistant for the Physical Plant, replaces the bins in its centralized locations. Aluminum goods are sent to Gulf Coast Metal, while the paper goods go to the Smurfit-Stone Company. "We receive $10 per ton of paper collected," Monroe said. Physical Plant funding made up roughly less than one percent of the Education and General Budget for 2002-03, so the program relies on the money collected from the recycled goods.
Tom Kane, director of university housing, admits that there really is not a recycling program for the campus residence halls. "There is always a group of students at the start of the semester who are excited about recycling, and we are willing to accommodate them," Kane said. Accommodating students means providing recycling bins and student volunteers to collect the waste. However, according to Kane, by the middle of the semester students' enthusiasm for recycling wanes. Unless students are willing to pay more, the program will continue to rely on the goodwill of volunteers.
As a state institution, USF should promote the wider benefits that accrue from recycling. A program that makes it easy for the burgeoning on-campus population to recycle without penalizing students financially would be a welcome addition to the university's existing program. But such a program is only worthwhile if students show a commitment to recycling that endures past Labor Day. Simply driving to Sycamore with their separated goods would be a start.


text:
Justine Allison
Justine Allison // Shifting Lines
Back to The Language of Clay
Shifting Lines opened at the Mission Gallery in Swansea in January 2018. It will tour to Ruthin Craft Centre, Llantarnam Grange Arts Centre, the Ceramic Gallery at Aberystwyth Arts Centre and Craft in the Bay.
Ceri's introduction to the publication accompanying the exhibition:
Justine Allison's intricately made vessels are eloquent and uplifting. Effectively so because of their unassuming presence. Light is attracted to them, held, and radiates from them. There is a quietude to Justine's work that reflects both the meditative process of its making and the grace of the finished forms. They are not perfect, they are precise. They have strong lines and soft colours. They are fixed forms that convey movement. They are vessels that make us hold our breath.
Lines from land and urban strata are in the fabric and decoration of Justine's vessels. The lines drawn into the clay as well as the ceramic edges evoke movement in each piece. The vessels shift as they are built, settle as they dry and alter again as they are fired. They have a poise born out of the fragility of their material and the robustness of its qualities. Porcelain is a very fine clay body to manipulate and Justine does so with skilful tenacity. Once it is fired to a high temperature, vitrified, it is stable and strong and luminescent.
Families of vessels have familiar traits and pleasing differences. They sit comfortably in groups, chime as pairs or sing out as individual pieces. The seemingly most simple of small, cupped bowls can be utterly alluring. Justine applies gold leaf to the inside surface of select small bowls. This gives an ethereal quality that can dazzle.
Form, for Justine, is paramount. Function is a driving motivation, but it is the aesthetics of a piece that are key to her making. Taking a functional vessel, such as a jug or a spoon, as a starting point, Justine will work her thinly rolled sheets of porcelain at just the right pace to capture the form. She describes it as drawing with the clay. Like a drawing, the marks of making remain. Lines, stripes, rubbed colour, lettering, hemp twine, gold leaf or palladium, any of these contribute to the considered aesthetic of finished jugs, pots, bowls and spoons.
Justine has her own language of clay. Balanced between functional and sculptural, her ceramic practice is rich and original. With a profound understanding of her materials and a honed visual aesthetic, Justine's vessels are resolved. It is such a pleasure to have this solo show by Justine as the opening exhibition in the second series of The Language of Clay. It expands the dialogue presented through the first series and celebrates singular expertise.
justineallison.blogspot.co.uk
'The sun shines through the dusty windows of Justine Allison's rural workshop in mid Wales. But there is nothing rustic about the refined porcelain vessels that are caught in the light. Hand-built from thin slabs of clay she creates precise forms - beakers, pourers and sharp-edged vases decorated minimally with line. Justine Allison's ceramics are skilfully made, precious to touch and a delight to the eye.'
Professor Moira Vincentelli
Consultant Curator of Ceramics, Aberystwyth University


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text:
Q: Qt: save QPixmap to std::vector - or convert QByteArray to std::vector I wanted to convert a QPixmap to std::vector . For now I am doing the following
     QPixmap pixmap;
     QByteArray bytes;
     QBuffer buffer(&bytes);
     buffer.open(QIODevice::WriteOnly);
     pixmap.save(&buffer, "JPG");

However I donot know how to convert QbyteArray to std::vector<unsigned char>
any suggestions ?

A: Just for the record, as user @Lol4t0 didn't do it:
 std::vector<unsigned char> c(bytes.constData(), bytes.constData() + bytes.size());


The data landscape is changing. This opens a big opportunity for businesses. Build data into all your apps, deliver powerful insights over big data and the ability to modernise your apps with built-in analytics are only some of the potential Azure SQL Database offers.
Make building and maintaining applications easier and more productive. With built-in intelligence that learns app patterns and adapts to maximize performance, reliability, and data protection, Azure SQL Database is a cloud database built for developers.
Microsoft Azure allows you to quickly deploy infrastructures and services to meet all your business needs. You can run Windows and Linux based applications in 36 Azure datacenter regions, delivered with enterprise grade SLAs.
*Premium RS – Designed for IO-intensive workloads where a limited durability guarantee and lower SLA is acceptable. Premium RS runs with a lower number of redundant copies, which means that in case of a potential service failure scenario, a recovery from a backup representing up to a five-minute lag in data capture may be required.
*Premium – designed for IO-intensive production workloads with high-availability and zero downtime. Premium is fault-tolerant and automatically handles read and write availability with a 99.99% availability SLA.


text:
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Added on September 20, 2021 Kurt Verlin Big Three , Carbon neutrality , congress , electric cars , elon musk , EV tax credit , Partisan issues , President Biden , Tax incentives , unions
EV Tax Credit Bill Faces Opposition from Tesla, Toyota, and Republicans
Pro-EV, pro-union bill accused of favoring Big Three automakers
Photo: Ralph Hutter via Unsplash
Democrats are attempting to move a bill through Congress that would allow American customers who purchase an electric vehicle to get $12,500 back on their taxes, up from $7,500 currently. However, the bill has several stipulations that have turned it into a partisan issue.
Among The Big Three: History of Jeep in America
Changes to the current EV tax credit
At the moment, EV customers benefit from a $7,500 incentive on most electric cars. This is not intended to change. However, the bill would lift a cap that removes the credit once a manufacturer has sold 200,000 EVs, which so far only two have done: Tesla and General Motors. The bill would also introduce a smaller credit of $2,500 for used EVs. But these are not the changes that have received pushback.
The most contentious part of the bill is the additional $4,500 credit that would be offered exclusively for EVs built with unionized labor. Combined with another $500 incentive for cars using U.S.-made batteries, it would give American buyers up to $12,500 in EV tax credits — but only if they buy the right nameplates from the right brands.
Accusations of favoritism
Volkswagen, Toyota, Honda, and other foreign automakers with U.S. assembly plants were quick to oppose the plan. Though the EV tax credit bill is a key part of President Joe Biden's goal to ensure EVs make up at least 50 percent of U.S. vehicle sales by 2030, the aforementioned automakers believe it unfairly favors Detroit's Big Three manufacturers.
Tesla has also come out in opposition of the bill, which is notable not only because it is one of the two automakers that would benefit from the lift of the 200,000-sales cap, but also because it is the only automaker that domestically produces 100 percent of the vehicles it sells in the U.S. — something the bill is purported to encourage.
According to Michigan Democrat Dan Kildee, the bill "puts American manufacturers in the lead, which is where we want them, and it reduces emissions faster than any other policy that we could put in place." But Tesla CEO Elon Musk says it's "not obvious how this serves American taxpayers" and accused the $4,500 credit as being "written by Ford/UAW lobbyists, as they make their electric car in Mexico."
Toyota stated the proposal "runs counter to the goal of carbon reduction" and that it would "fight to focus taxpayer dollars on making electrified vehicles accessible for American consumers who can't afford high-priced cars and trucks." Honda said that its workers "deserve fair treatment from Congress and should not be penalized for their choice of a workplace."
Photo: Ernest Ojeh via Unsplash
Additional EV tax credit limitations
In addition to stipulations about how the electric vehicles are made, the EV tax credit has other provisions. It won't apply to EVs with price tags exceeding the following thresholds: $55,000 for sedans, $64,000 for vans, $69,000 for SUVs, and $74,000 for pickup trucks. Individuals with an adjusted gross income of $400,000 or more will also be ineligible, as well as couples earning more than a combined $800,000. By 2027, only U.S.-built vehicles would qualify.
These provisions have received criticism from the other side of the aisle in Congress. Republican Carol Miller of West Virginia said it was "hard to imagine how giving a tax break of $12,500 to someone buying a $74,000 electric vehicle is a way to help working class workers." Republican Drew Ferguson of Georgia proposed an amendment that would lower the maximum income limit to $75,000 for single filers, which was rejected.
Ultimately, the new bill is intended to achieve two things: promote EV adoption and promote unionized labor. It's clear that the latter is tripping up even the automakers who have a vested interest in the former.
It's easy to argue that if the goal is to reduce carbon emissions, then a blanket EV incentive should be the way to go — after all, it would be tough for Toyota to justify developing an all-electric SUV that competes with a Mustang Mach-E that has a permanent $4,500 discount attached to it. It would have to make a significantly better SUV than Ford to even compete.
But that may be exactly what the Democratic Party wants. Foreign automakers claim their employees choose not to unionize, but it's no coincidence they build their manufacturing plants in anti-union states with "right to work" laws that make it more difficult for workers to leverage their collective bargaining power.
If the bill passes, then consumers will not only be incentivized to buy EVs, but manufacturers will also be incentivized to support unions to the benefit of their employees, if they wish to remain competitive. Everybody wins — except, perhaps, for a few corporations' bottom line.
Kurt Verlin
Kurt Verlin was born in France and lives in the United States. Throughout his life he was always told French was the language of romance, but it was English he fell in love with. He likes cats, music, cars, 30 Rock, Formula 1, and pretending to be a race car driver in simulators; but most of all, he just likes to write about it all. See more articles by Kurt.
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On 23 January, EULEX Head of Mission, Alexandra Papadopoulou, took part in the second Justice 2020 meeting, hosted this time by the Kosovo Judicial Council in close cooperation with the Ministry of Justice and the Kosovo Prosecutorial Council.
During the meeting, Papadopoulou noted that Justice 2020 is a remarkable initiative as it is locally-driven, comprehensive and ambitious.
"Its two main features are local ownership and a focus on practical solutions to real problems in the justice system. This is the right approach to enact reforms able to garner enough support, which can be sustainable over time and which aim at showing tangible results for all,"said EULEX Head.
During the meeting, the interlocutors had some well-focused discussions aimed at a finding a hands-on approach to tackle some of the most pressing issues identified under the Justice 2020 initiative.
"With that in mind, EULEX has contributed to the discussions by identifying issues to be tackled, based on the Mission's systemic and thematic robust monitoring of prosecutorial and judicial cases in the Kosovo system in very close cooperation with the Kosovo judicial and prosecutorial authorities. EULEX also provided practical recommendations to solve a number of structural weaknesses in the Kosovo justice system, including the backlog of cases affecting local prosecution offices and courts. Our focus is on identifying issues and offering practical solutions so to help the justice system actors to address them," stressed Papadopoulou.
"Justice 2020 is a remarkable initiative as it is locally-driven, comprehensive and ambitious," said EULEX Head Papadopoulou, during the second Justice 2020 meeting, hosted this time by the Kosovo Judicial Council in close cooperation with the Ministry of Justice and the Kosovo Prosecutorial Council.
Papadopoulou also noted that EULEX contributed to the discussions with findings and recommendations based on the Mission's systemic and thematic robust monitoring of prosecutorial and judicial cases in the Kosovo system in very close cooperation with the Kosovo judicial and prosecutorial authorities.
"Our focus is on identifying issues and offering practical solutions so to help the justice system actors to address them", stressed Papadopoulou.


text:
Анна Мария Пфальц-Нейбургская (; 18 августа 1575, Нейбург — 11 февраля 1643, Дорнбург) — принцесса Пфальц-Нейбургская, в замужестве герцогиня Саксен-Веймарская.

Биография
Анна Мария — старший ребёнок в семье пфальцграфа и герцога Филиппа Людвиг Пфальц-Нейбургского и его супруги Анны Юлих-Клеве-Бергской, дочери герцога Вильгельма.

9 сентября 1591 года в Нейбурге Анна Мария вышла замуж за Фридриха Вильгельма I Саксен-Веймарского, став его второй супругой. По случаю бракосочетания была выпущена золотая монета с изображениями новобрачных с двух сторон. В 1604 году Анна Мария с детьми переехала из Веймара в Альтенбург, её сыновьям из состава Саксен-Веймара было выделено отдельное герцогство Саксен-Альтенбург. Овдовев, Анна Мария впала в глубокую депрессию и с 1612 года проживала отдельно от детей в предназначенном для неё амте Дорнбург. Во время Тридцатилетней войны в 1631 году на её дворец напали хорватские войска генерала Тилли, герцогиня Анна Мария стойко оборонялась, но её владения были разграблены, а она сама получила ранение в щёку. С помощью местных жителей дворец удалось отстоять, в благодарность герцогиня подарила церкви кубок. Анна Мария Пфальц-Нейбургская похоронена в замурованной ныне княжеской усыпальнице братской церкви в Альтенбурге.

Потомки
В браке с герцогом Фридрихом Вильгельмом родились:
 Иоганн Филипп (1597—1639), герцог Саксен-Альтенбурга, женат на Елизавете Брауншвейг-Вольфенбюттельской
 Анна София (1598—1641), замужем за герцогом Карлом Фридрихом Мюнстерберг-Эльсским (1593—1647)
 Фридрих (1599—1625), герцог Саксен-Альтенбурга
 Иоганн Вильгельм (1600—1632), герцог Саксен-Альтенбурга
 Доротея (1601—1675), замужем за герцогом Альбрехтом Саксен-Эйзенахским (1599—1644)
 Фридрих Вильгельм II (1603—1669), герцог Саксен-Альтенбурга, женат на Софии Елизавете Бранденбургской, затем на Магдалене Сибилле Саксонской.

Предки

Примечания

Литература
 Luise Hallof, Klaus Hallof: Die Inschriften des Landkreises Jena, Akademie Verlag, 1995, S. 159 f.
 Verein für Thüringische Geschichte und Altertumskunde, Jena: Zeitschrift des Vereins für Thüringische Geschichte und Altertumskunde, Band 6-7, G. Fischer., 1865, S. 248 f.
 Johann Samuel Ersch: Allgemeine encyclopädie der wissenschaften und künste, Band 50, J. f. Gleditsch, 1849, S. 81

Принцессы Пфальцские
Герцогини Саксен-Веймарские

redpajama_set_name: RedPajamaWikipedia


Is depression stealing your aliveness?
Depression can debilitate our mind and body; it can disrupt our appetite, sleeping patterns, vitality, mental attutude, relationships, productivity, clairty and self esteem. Depression can be such a lonely condition, causing us to isolate and become hyper-critical of our apparent inability to get on top of things.
If you relate to this, you are not alone! Almost 10% of us in the United States experience some form of depression in our lives.
You don't have to feel this way. There is hope. 80-90% of the people who seek help feel better within two weeks. Depression is no time to go it alone. It's so tempting to think that you should be happy, and then berate yourself because you aren't. I invite you to give yourself a break, adopt a bit of humility about what you should be able to do and reach out for help. I would be happy to speak with you and answer any questions you have.
Many people who are depressed don't reach out for help. For many, especially men, depression is seen as a personal weakness or failure that they should be able to just get over. If you are used to being able to handle things on your own it can be a stretch to ask for help. Some people are so used to feeling the symptoms of depression, it just feels like their "normal" and it doesn't occur to them to seek help. For others depression can be masked by drug or alcohol use. Alcohol or drugs allows for a temporary relief, but ultimately perpetuates depression and bad feelings, leading to another temporary solution with alcohol or drugs ... whew, what a vicious cycle!
Painful or traumatic life events. Grief over painful losses can build to a depression. Today's economy can trigger depression as people endure loss of home, repeated job losses and lifestyle changes.
Negative thinking habits. Is the glass half full or half empty? Habitual, negative thinking styles can wear down resilience and constructive responses to adversity. How we explain things to ourselves is often an important factor determining our vulnerabilty to depression.
Genetics and brain chemestry. There is evidence of a genetic component to depression and a linkage to hormonal or neurochemical imbalance. However, it is uncertain if the imbalance is the cause FOR or is caused BY depression.
While it is possible that all three of these factors contribute to a clinical depression, each person is different. It's hard to know what the causes are without taking a holistic view of the person who is experienceing symptoms of depression.
When you participate in therapy, you are no longer alone with your depression. This fact alone brings a huge amount of relief to many people at the very beginning of our journey together. Here some of the ways our work together will help you feel better and find yourself again.
We will explore and bring healing to unresolved events from the past that may be contributing to the way you feel.
We will learn about the specific beliefs and ideas you've identified with that no longer serve you. Our work together will create the safety and resourcefulness for you to let these ways of being go in order to make room for new ways that support and affirm you and the life you want to live.
We will restore your resilience and ability to respond constructively to the difficulties that can arise in the course of living your life.
Many people are helped by medication. This is a personal decision and one that we will explore together if it seems relevant to your situation. I don't prescribe medication. If medication seems like a direction we should take I will provide appropriate referrals.
My aim is your discovery of the resources within you to heal, grow, create, engage and interact.
If you are experiencing depression or depressive-like sypmtoms, I urge you to reach out for help. It's not time to be alone. Let's talk and see if I can help.


text:
namespace Microsoft.Azure.Management.Monitor.Fluent.Models
{
    using Microsoft.Rest;
    using Newtonsoft.Json;
    using System.Collections;
    using System.Collections.Generic;
    using System.Linq;

    /// <summary>
    /// Criterion to filter metrics.
    /// </summary>
    public partial class MetricCriteria
    {
        /// <summary>
        /// Initializes a new instance of the MetricCriteria class.
        /// </summary>
        public MetricCriteria()
        {
            CustomInit();
        }

        /// <summary>
        /// Initializes a new instance of the MetricCriteria class.
        /// </summary>
        /// <param name="name">Name of the criteria.</param>
        /// <param name="metricName">Name of the metric.</param>
        /// <param name="operatorProperty">the criteria operator. Possible
        /// values include: 'Equals', 'NotEquals', 'GreaterThan',
        /// 'GreaterThanOrEqual', 'LessThan', 'LessThanOrEqual'</param>
        /// <param name="timeAggregation">the criteria time aggregation types.
        /// Possible values include: 'Average', 'Minimum', 'Maximum',
        /// 'Total'</param>
        /// <param name="threshold">the criteria threshold value that activates
        /// the alert.</param>
        /// <param name="metricNamespace">Namespace of the metric.</param>
        /// <param name="dimensions">List of dimension conditions.</param>
        public MetricCriteria(string name, string metricName, string operatorProperty, string timeAggregation, double threshold, string metricNamespace = default(string), IList<MetricDimension> dimensions = default(IList<MetricDimension>))
        {
            Name = name;
            MetricName = metricName;
            MetricNamespace = metricNamespace;
            OperatorProperty = operatorProperty;
            TimeAggregation = timeAggregation;
            Threshold = threshold;
            Dimensions = dimensions;
            CustomInit();
        }

        /// <summary>
        /// An initialization method that performs custom operations like setting defaults
        /// </summary>
        partial void CustomInit();

        /// <summary>
        /// Gets or sets name of the criteria.
        /// </summary>
        [JsonProperty(PropertyName = "name")]
        public string Name { get; set; }

        /// <summary>
        /// Gets or sets name of the metric.
        /// </summary>
        [JsonProperty(PropertyName = "metricName")]
        public string MetricName { get; set; }

        /// <summary>
        /// Gets or sets namespace of the metric.
        /// </summary>
        [JsonProperty(PropertyName = "metricNamespace")]
        public string MetricNamespace { get; set; }

        /// <summary>
        /// Gets or sets the criteria operator. Possible values include:
        /// 'Equals', 'NotEquals', 'GreaterThan', 'GreaterThanOrEqual',
        /// 'LessThan', 'LessThanOrEqual'
        /// </summary>
        [JsonProperty(PropertyName = "operator")]
        public string OperatorProperty { get; set; }

        /// <summary>
        /// Gets or sets the criteria time aggregation types. Possible values
        /// include: 'Average', 'Minimum', 'Maximum', 'Total'
        /// </summary>
        [JsonProperty(PropertyName = "timeAggregation")]
        public string TimeAggregation { get; set; }

        /// <summary>
        /// Gets or sets the criteria threshold value that activates the alert.
        /// </summary>
        [JsonProperty(PropertyName = "threshold")]
        public double Threshold { get; set; }

        /// <summary>
        /// Gets or sets list of dimension conditions.
        /// </summary>
        [JsonProperty(PropertyName = "dimensions")]
        public IList<MetricDimension> Dimensions { get; set; }

        /// <summary>
        /// Validate the object.
        /// </summary>
        /// <exception cref="ValidationException">
        /// Thrown if validation fails
        /// </exception>
        public virtual void Validate()
        {
            if (Name == null)
            {
                throw new ValidationException(ValidationRules.CannotBeNull, "Name");
            }
            if (MetricName == null)
            {
                throw new ValidationException(ValidationRules.CannotBeNull, "MetricName");
            }
            if (OperatorProperty == null)
            {
                throw new ValidationException(ValidationRules.CannotBeNull, "OperatorProperty");
            }
            if (TimeAggregation == null)
            {
                throw new ValidationException(ValidationRules.CannotBeNull, "TimeAggregation");
            }
            if (Dimensions != null)
            {
                foreach (var element in Dimensions)
                {
                    if (element != null)
                    {
                        element.Validate();
                    }
                }
            }
        }
    }
}

redpajama_set_name: RedPajamaGithub


Successfully Added 1 DIN Android 7.1 Car Media Player - 10.1 Inch Display, Touch Screen, GPS, Bluetooth, 3G, Google Play, Quad-Core CPU to your Shopping Cart.
Entertain your passengers on the road with this 1DIN car media player and be assured that there will never be a moment of boredom during your upcoming road trips again. With its Android operating system, this car media player comes packed with the latest features the industry has to offer. Watching movies, playing music, hands-free phone calls, and even browsing the web – with this 1 DIN media player your options will be limitless. So head out on the road with confidence, as with this little car upgrade you can be assured that your passengers can enjoy a fun filled trip without exception.
Packing a Quad-Core CPU and holding 2GB of RAM this Android media system allows you to smoothly enjoy the latest media, games, and applications alike without dropping a frame. Thanks to its stunning 10.1 Inch display and Mali-400MP graphic's unit you will be able to enjoy all media in mesmerizing graphics and detail, offering your passengers a true cinematic experience while out on the road. Its Android operating system additionally lets you play games and enjoy the latest mobile applications – brining along tons of entertainment to keep your children or passengers busy while on your way to reach your upcoming holiday destination.
Supporting an extremely accurate GPS, this 1 DIN media player can additionally be used as a top class navigation system. Supporting Android maps you will be able to download and insert your own maps, ensuring that no matter where on the globe your next trip will bring you – with this Android car media entertainment system you'll always be able to find the quickest road to your next destination. With its 3D interface and built-in porcelain antenna, you can be guaranteed that your 10.1 display will show you a highly accurate and detailed image of your current position, ensuring that you'll never get lost again.
With its Bluetooth support, you will be able to easily pair your smartphone with this Android media player, letting you answer phone calls and allowing you to engage in hands-free conversations while in traffic. Additionally, you will be able to sync the media player with your smartphone music library, letting you enjoy your favorite tracks in stunning audio quality.
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This 1 DIN car media player comes with a 12 months warranty, brought to you by the leader in electronic devices as well as wholesale electronic gadgets..
Arabic: - مشغل دي في دي السيارة الروبوت - Chinese Simplified: - 安卓车载 DVD 播放器 - Czech: - Android auto DVD přehrávač - Dutch: - Android auto-DVD-speler - French: - Lecteur DVD de voiture Android - German: - Android Auto DVD-Player - Hebrew: - נגן DVD לרכב אנדרואיד - Hindi: - एंड्रॉयड कार डीवीडी प्लेयर - Hungarian: - Android autós DVD-lejátszó - Italian: - Lettore DVD dell'automobile di androide - Japanese: - Android の車の DVD プレイヤー - Korean: - 안 드 로이드 자동차 DVD 플레이어 - Malay: - Pemain DVD kereta Android - Norwegian Bokmål: - Android bil DVD-spiller - Romanian: - Android auto DVD Player - Russian: - Андроид автомобильный DVD-плеер - Spanish: - Android reproductor de DVD - Thai: - รถหุ่นยนต์ - Turkish: - Android araba DVD oynatıcı - Vietnamese: - Android xe máy DVD.


text:
Trade Show Catalog
About the Background
ⓒ 2021 Foreword Magazine, Inc.
Brave Love: Susan Wittig Albert and "Loving Eleanor"
Bestselling author Susan Wittig Albert's name is a brand. Her titles dominate whole shelves in libraries, and circulate without resting. When she turned to a new publishing venture—her own press, Persevero–she was bound to do something equally notable with it. And Persevero's titles don't disappoint; they are doing something extraordinary, with both care and style. They pull forth the stories of notable American women, names that are known but not fully appreciated, and reconstruct them with respect and nuance, honoring their pains, their struggles, their defiances, and ultimately, their triumphs.
Loving Eleanor is Persevero's second title. It relates the story of groundbreaking reporter Lorena Hickok and her relationship with Eleanor Roosevelt, a connection too long hidden beneath obfuscation and innuendo. Albert's novel treats Hick and Eleanor's relationship with the dignity it is often denied, and her book has charmed audiences as a result. Albert recently won a Library Journal award for the title; we asked her about this and more.
What prompted you to write a novel based on Eleanor and Hick's connection? Why did you choose to write it from Hick's perspective?
Susan Wittig Albert. Persevero titles are about 'the politics of truth-telling and suppression in a media age.'
I read about Lorena Hickok and [Eleanor Roosevelt] in Blanche Cook's wonderful biography of ER. I was intrigued by Hick's story and followed the trail of footnotes to Doris Faber's 1980 biography, The Life of Lorena Hickok: E.R.'s Friend. I was offended—perhaps 'horrified' is a better word—by Faber's biased treatment of the relationship, and of Hick herself. I knew there was an important story, but Faber hadn't told it.
I wrote from Hick's point of view because it was her story. Hick loved longer, loved more deeply, and loved in spite of all. Because Hick shaped ER's political life in a way that had not been acknowledged. And because Hick was brave: she saved the letters and made certain that they would be preserved, to be read in a more compassionate and enlightened (we hope!) time.
The response to Loving Eleanor has been wide and enthusiastic; it recently won a Library Journal award. Why do you think this story strikes such a chord with readers?
Readers tell me that this story opens a new view of the most important woman of the American twentieth century and gives them a glimpse into the way two women care for and support each other through decades of personal and political turmoil. They value the story more because it is true: it is dramatized only as far as the letters and historical documents allow, and the documentation supports the story. Even people who are troubled by the early intensity of the physical relationship are moved by what one reader called "the deeply cherishing, caring, missing, loving-each-other's-faults-too kind of way that is the hallmark of true love." It's a love story, pure and simple, and I was delighted when Library Journal recognized it for the Indie Award as a "romance."
How do you think Hick would've covered the 2016 presidential election?
Hick was never polite and she didn't know how to be politically correct. She would have supported HRC, of course; she admired brave women who did impossible things. She would have been profoundly and publically angered by the GOP candidate's misogynist, racist, and homophobic points of view. She would have jumped on the lies, flagrant spin, and fake news stories (she was deeply passionate about facts). She would have reminded people of the rise of German Nazism in the mid-1930s, and in our own country, of Father Coughlin, Huey P. Long, and the KKK.
Can you tell us a little bit about Persevero Press—how it started, and why independent publishing was the right route for you?
I created Persevero Press in 2013 when I met with thirty-plus rejections of the manuscript of A Wilder Rose, the true story of Rose Wilder Lane's transformation of her mother, Laura Ingalls Wilder, into a literary icon. I published the book via Persevero Press, sold 21,000 print and e-book copies online in the first year, and then sold the reprint rights and another 40,000 copies. The book is currently under film contract. Loving Eleanor (2016) is Persevero's second title. A third, The General's Women, will be published in March, 2017.
Indie publishing was a no-brainer. I knew I had a significant story to tell and a manuscript I believed in (these two are not always the same thing). I also had a substantial platform, built over twenty-five years as the author of four long-running, traditionally published mystery series and supported by a monthly e-letter, a large mailing list, and an Internet and social media presence.
Also important: by 2013, the technologies of POD publishing and online book marketing had matured to the point where publication was possible—not easy, definitely, but doable. The learning curve has been steep, but I have excellent help from Kerry Sparks at Levine Greenberg Rostan, and together we have assembled a production team that makes the work go relatively smoothly.
What projects do you have coming out next?
In March, Persevero Press will publish The General's Women, a novel about the wartime love triangle of Ike, Kay Summersby, and Mamie Eisenhower. Like Loving Eleanor, The General's Women is fact-based biographical/historical fiction, fully documented and with an Epilogue that traces Kay's postwar life and an Afterword that explores what is for me the real story: the politics of truth-telling and suppression in a media age.
In April, Berkley Prime Crime and I are celebrating the twenty-fifth anniversary of the China Bayles mysteries in April, with the publication of The Last Chance Olive Ranch. I owe an enormous debt of gratitude to former Prime Crime editor Natalee Rosenstein for her support and nurturance over a (gasp!) quarter-century.
Our audience includes many librarians, and your books are a huge hit in public libraries. Do you have any strong library memories?
The first library in my life: the Carnegie Library in Danville IL. On my eighth birthday, I asked for permission to ride downtown alone on the bus to go to the library. I'll never forget how grown-up I felt climbing those steps by myself that first time. (Would I let an 8-year-old daughter do that now? Probably not, and that's a loss.)
The most important library in my life: the main library at UC Berkeley, where I had a carrel as a grad student and practically lived in the stacks. Utterly amazing, the things that could be found in that library.
The most fun with a library: as an administrator at what is now Texas State University in San Marcos TX, helping to plan the Alkek Library. I felt like a kid with my very own playground.
The greatest joy: hearing from people who recall my author-visits to their small-town libraries a decade or two ago. Lovely to know that they remember, and that it was a library that brought us together.
Michelle Anne Schingler is the managing editor at Foreword Reviews. You can follow her on Twitter @mschingler or e-mail her at mschingler@forewordreviews.com.
Michelle Anne Schingler
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Knockoff pride. Could Steve Madden introduce a high-end line without taking aim at cliched high-end imagery? We took the standard fashion phrase ''London-Paris-New York,'' and changed it 33% to celebrate Steve's home borough. In each ad, models were shot in front of real Queens locations.


text:
import org.apache.maven.model.Model;

public class Main
{
    public Model model = null;
}


text:
Remembering the day Mo Johnston left Celtic and signed for Rangers
Rangers fans were pictured burning their scarves almost 30 years ago - but most were soon won over by Johnston's goals. The real pain, however, was felt at Celtic Park.
Glasgow Live
It was one of the most controversial days in Scottish football - and almost three decades later, remains a talking point among fans.
As Glasgow gets ready to ring in 2019, we're taking a look back to 30 years before - when Maurice 'Mo' Johnston signed for Rangers.
It happened on July 10, 1989, and only months after Johnston announced his intention to return home to Celtic, once his contract ran down in France.
Remember when a team from Scotland won the World Cup? The incredible story of Renton F.C
Instead, he arrived at Ibrox to sign for the Gers - and stunned the waiting press.
The move made headlines the world over because it was said to break Rangers' unwritten policy of never signing Catholic players. Of course, this signing policy has been overstated. Rangers did sign Catholics; just not high-profile ones who used to play for Celtic.
In fact, there is believed to have been up to 15 Catholic first-team Rangers players before the signing of Johnston, including John Spencer and the South African Don Kitchenbrand.
In the immediate days after Johnston signed up at Ibrox, some Rangers fans were pictured burning their scarves and claiming they would never return - but most were soon won over by Johnston's goals.
The real pain was felt across the Clyde at Celtic Park. Make no mistake: it took the Hoops a long time to recover.
Mo Johnston celebrates with Celtic fans after the Hoops clinch the Premier League Championship, 1986 (Image: Media Scotland)
Rangers manager at the time Graham Sounness spoke recently of the move and the thinking behind it, commenting: "There was an element of mischief in it, I believed we were hurting Celtic by signing him.
"Every Rangers manager had said in the past that they'd sign a Catholic, but I meant it.
"I was married to a Catholic, my children were Catholics. Religion was never an issue with me."
Johnston had started his career at Partick Thistle, making his debut in 1979, and blasted in 41 goals in 85 appearances as a youngster before Watford whisked him down south in 1983.
A similarly prolific spell seen him bag 23 goals in 38 games in one year before his boyhood heroes, Celtic came calling.
Rare Scottish Cup medal sells at Glasgow auction
Maurice Johnstone signed for Celtic in 1984 and spent three seasons with the club. He left having won one League and a Scottish Cup to join Nantes in France.
Celtic had been losing players throughout the previous decade after Davie Hay left for Chelsea in 1974. With the old board's infamous 'biscuit tin' mentality the club simply would not sanction the wages that were on offer elsewhere.
Johnston therefore left with little acrimony from the fans. They blamed the board for the steady stream of players departing for bigger bucks elsewhere.
It wasn't long before the journeyman was getting itchy feet again.
Johnston blamed the politics of international football for his departure, stating: "The second year was a lot more difficult because we had drawn the French in the World Cup and I was flying back and forth for our World Cup games.
Take a trip down memory lane with Glasgow's long lost football grounds
"The club wasn't happy, I scored two goals in the qualifiers against France in Scotland. At that time the club financially was a little bit on the backbone.
"They weren't looking to sell me but it got to the stage where I was being used as a pawn."
By the time Johnston was ready to leave Nantes, the balance of power had shifted in Glasgow. Graham Souness had arrived to manage Rangers and David Murray had become the club's new owner.
Maurice Johnston signs for Rangers alongside manager Graeme Souness, July 1989 (Image: Media Scotland)
The duo were in the midst of shaking up Scotland but it appeared that Johnston only wanted to sign for Celtic at that juncture.
He spoke to his friend Roy Aitken on Scotland duty and asked him to inform Celtic that he wanted to return. Then on May 12, 1989, the Scotland international was unveiled as a Celtic player again with the club having agreed a £1.2m fee with Nantes.
Johnston said that day: "I didn't want to leave Celtic then [in 1987] and I don't intend to now.
"There was some rubbish about me wanting to join Manchester United but it never entered my head to play for any other club. In fact, there is no other British club I could play for apart from Celtic."
Remembering Jimmy Speirs - Rangers' lost hero of Passchendaele
Johnston even travelled with Celtic on the team bus at the end of the 1988-89 season, to a game against St Mirren at Love Street.
However, reports soon suggested Celtic had failed to meet payments on the deal and the transfer seemed to off all of a sudden. Few could have foreseen what was to come next.
The rumours had been flying around Glasgow in the days and weeks beforehand but nobody took them too seriously.
Mo Johnston would surely not be signing for Rangers?
Sure, Murray and Souness were shaking things up and probably would sign a high-profile Catholic but it would be one of the guys from down south, like Ray Houghton, Ian Rush, Derek Statham.
That it would be the Celtic player who once blessed himself at Ibrox after being shown the red card was beyond comprehension.
Ally McCoist with his arm around fellow Rangers player Mo (Image: Media Scotland)
A chance encounter between Souness and Johnston's agent, Bill McMurdo, in the Ibrox foyer changed everything. Johnston's camp was receptive so it was down to Souness to convince the bosses at Ibrox that the deal could work.
In his book Souness said: "There was some resistance within the club, with other directors feeling that the fans would desert us in droves in protest, but I argued that very quickly Maurice would win the right-minded majority over with his industry and goalscoring, and I was proved right on that score."
After a FIFA ruling it was decided that Johnston was a Celtic player, and if the club paid the fee for his transfer, he would be their player and unable to play elsewhere. Celtic manager Billy McNeill sought him out and said: "You mess me about and I'll fight you all the way. I'll make sure you never play again.'"
However, the Celtic board of the day did not have the mettle to take this on and eventually pulled out - the player was free to sign for Rangers.
From Bellshill to Serie A - the forgotten story of Billy Chalmers
To say Glasgow came to a standstill is something of an understatement.
Police were called to disperse an angry mob from Ibrox as a smattering of fans burned their season books and vowed to never return.
David Miller, secretary of the Rangers Supporters Club Association, conveyed the frustrations of some with: "The majority of the fans at Ibrox will not take to him, of that I am sure, because of his history.
"Mr Souness may be the manager but we are the supporters. There is no doubt Johnston will get stick from the Celtic fans as well as the Rangers supporters."
The anger at Ibrox quickly dissipated as Johnston got about the goals and contributed heavily on the park. Johnston was even invited recently to come on the park and do a half-time draw at Ibrox.
Mo Johnston's first goal for Rangers against Celtic, November 1989 (Image: Media Scotland)
Across the city at Celtic Park, feelings have never really thawed. Johnston has said his biggest regret was "letting down" the late Tommy Burns.
After leaving Ibrox and with spells at Everton, Hearts and Falkirk he moved to America to escape the goldfish bowl of Scottish football. He then took up a managerial position in Canada with Toronto FC and has said he has no plans to return home anytime soon.
Years later, one of Tommy Burns' sons came to Toronto to do some coaching. Johnston, then director of football at Toronto FC, took him under his wing.
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But it's likely he knows he will never be truly forgiven by the masses at Celtic Park.
Celtic's most successful captain, Billy McNeil, was the manager in 1989 and he has since spoken of Johnston, dismissing the significance at the ending of a sectarian signing policy. McNeil said he was convinced it was one-upmanship and the intention to prove themselves as the biggest club in Glasgow that motivated Rangers.
With the moment still fresh in the minds of many almost 30 years on, it's difficult to imagine a more controversial signing in Scottish football.
Ibrox Stadium


Part of our partnership with Vogue Italia, these Keshi Fijian Pearl Earrings were created for Assael by J.Hunter. Two pairs of natural Keshi Fijian pearls sit above each other, separated by white gold connectors. Featuring post closures. Handcrafted and one-of-a-kind. 10% of all proceeds goes to Space for Giants.
This item measures: 9.3mm x 9.1mm x 6.9mm pearls and 10.0mm x 9.2mm x 7.0mm pearls.


The government has published the first draft of the Flexible Working (Procedural Requirements) Regulations 2002, made under the Employment Act 2002. They are intended to come into force on 6th April 2003.
As readers will know, the Employment Act 2002 gives employees with children under six a right to request flexible working. The employer is under no duty to accede - but must consider the request, hold a meeting with the employee if it intends to refuse, and put its reasons for refusal in writing.
• the employee has the right to be accompanied at any meeting. Breach of this provision results in a compensation payment of up to two weeks' pay (limited to, currently, £250pw).
The Regulations can be seen at http://www.dti.gov.uk/er/flexdraftregs.pdf (Adobe Acrobat required).


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