I just had to delay the after market report to get this post written.. the market report will come later tonight.
It was mighty amusing to see the sell ratings on Thornburg Mortgage from Citigroup and AG Edwards today. Oh OK, right got it. Now I should no longer hold TMA and dump it. Great work and great timing guys. Or how about the sell rating on Countrywide Financial (CFC) out of Merrill Lynch this morning from Kenneth Bruce just days after he called the issues with CFC media sensationalization. Again, fantastic timing. Remind me again exactly what you guys get paid the big bucks for? Apparently we are seeing the same thing in the lender business as we saw back in the internet bubble days. Despite the lawsuits and the promises, the jail sentences… nothing has really changed. It's the same game. Either these analysts are asleep at the wheel, incredibly incompetent in getting to the truth about the company's they are paid to cover or flat out frauds. Harry Domash wrote up an excellent piece today highlighting the downfall of American Home Mortgage (AHM) and the analyst upgrades/dowgrades along the way. I'm sure there are other excellent articles out there from fellow bloggers that I have missed or just haven't had the time to read so if anyone reading this has a link I'd be happy to post it here. Below are histories of upgrades and downgrades for 3 lenders with plummeting stock prices (AHM has filed for bankruptcy). It's very interesting to see when the upgrades/downgrades were made.
Below is the history for Thornburg Mortgage (TMA). What stands out to me here is the hold rating from Deustche Securities, the buy rating from AG Edwards and the sector perform rating from RBC Capital Markets at the end of April. These guys must take long vacations because it wasn't until Aug 7th AFTER the stock plunged 30% over several days that Deutsche Securities was the first to downgraded the stock. Three days later AG Edwards downgraded the stock from Buy to Hold! As if they were just reacting to news that we all receive on these companies and not acting on the best inside research money can buy, the sell rating didn't come until a full week later. That was today. The stock had already plunged another 60% before that sell rating came. Job well done.
This is a fun one. .. American Home Mortgage (AHM). A lender that has filed for bankruptcy with investors heeding the advice of these brokers losing everything. How about that, our good friend AG Edward showing up again! This time recommending a buy on a company that would just a few months later declare bankruptcy. Notice they last issue a downgrade to hold on May 1st, then nothing more… maintaining a hold all the way into bankruptcy. Sorry for singling you out AG Edwards, but you guys are really on a roll here!
"During the quarter, softening home prices continued to affect many areas of the country and delinquencies and defaults continued to rise across all mortgage product categories as a result. Due to these adverse conditions, the Company incurred increased credit-related costs in the quarter, primarily related to its investments in prime home equity loans."
"We are experiencing home price depreciation almost like never before, with the exception of the Great Depression"
This sounds like a reason to upgrade to me!


Why is Knowledge of Finance required for Engineers ?
Money is the universal language of business. Even technology leaders are required to have a good knowledge of finance fundamentals and this is essential for them to grow in any organization. The industry now requires well rounded individuals with a good understanding of Business & Finance along with their expertise in technology.
Engineers often ignore the above aspect and focus only on their technical skills. Typically, Engineers would not like to spend time going through several text books and online material to learn the fundamentals of finance. Most of the text books and online material available today cover a wide range of finance topics that may not be relevant for an engineer at work. Sound Basics has synthesized this vast theoretical knowledge in a concise format and then combined it with the absolutely essential practical knowledge. This ensures a comprehensive learning experience within just 20 hours of study !
How can SoundBasics help Engineers ?
Having strong fundamentals in Business & Finance can be a differentiating factor for an engineer and can make him/her standout in the crowd. There is a high influx of engineers in the industry but very few are well rounded and understand business concepts. SoundBasics can provide this differentiator and can increase the success rate of engineers in interviews as well as in their jobs.
The SoundBasics course 'Business Accounting for Engineers' focuses on the essentials of Finance which are required by engineers in any organization. The course is created using synthesized and relevant content that demystifies the complex finance content currently available in most theoretical courses and reading material.
This "crash course" in Business Accounting can be a huge advantage to Engineers who are looking to stand out in their organizations and progress to leadership positions.
Description: Money is the language of business. Even technical leaders are required to have a good knowledge of finance fundamentals and this is essential for them to grow in any organization.


GB/T 7714 Peng, Yin-Biao,Yu, Sheng-Yao,Zhang, Jian-Xin,et al. Early Paleozoic arc magmatism and metamorphism in the northern Qilian Block, western China: Petrological and geochronological constraints[J]. GEOLOGICAL JOURNAL,2017,52:339-364.
APA Peng, Yin-Biao,Yu, Sheng-Yao,Zhang, Jian-Xin,Li, San-Zhong,Tong, Lai-Xi,&Sun, De-You.(2017).Early Paleozoic arc magmatism and metamorphism in the northern Qilian Block, western China: Petrological and geochronological constraints.GEOLOGICAL JOURNAL,52,339-364.
MLA Peng, Yin-Biao,et al."Early Paleozoic arc magmatism and metamorphism in the northern Qilian Block, western China: Petrological and geochronological constraints".GEOLOGICAL JOURNAL 52(2017):339-364.


text:
Q: How do you check for nullable value in an if statement I have the following code:
string thing="";
if(request.Session.Attributes?.TryGetValue("varName", out thing))
{
  //do stuff
}

request.Session.Attributes is a dictionary.
I understand that you can't have if(bool?) which is what the above does.
I also know that you can have .GetValueOrDefault() so that null will be treated as false.
But I can't do request.Session.Attributes?.GetValueOrDefault().TryGetValue("varName", out thing)
So what is the correct way to return false if Attributes is null otherwise return the bool from the TryGetValue?

A: I suspect you're looking for:
if (request.Session.Attributes?.TryGetValue("varName", out thing) == true)

Alternatively:
if (request.Session.Attributes?.TryGetValue("varName", out thing) ?? false)

The null-coalescing ?? operator here is effectively saying "If we didn't call TryGetValue because Attributes is null, this is what I want to pretend it returned."

A: A quick and slightly dirty way is doing:
string thing="";
if(request.Session.Attributes?.TryGetValue("varName", out thing) ?? false)
{
  //do stuff
}

In this way you are sure that if Attributes is null, the second branch of the ?? will be chosen and it will not get inside the if.
Personally, I would split it, as having it in a 1-liner does not improve the code that much. It'd become:
string thing="";
var attributes = request.Session.Attributes;
if(attributes != null && attributes.TryGetValue("varName", out thing))
{
  //do stuff
}

This is much more readable. Sometimes it is just fair to avoid using new features of the language if they do not improve the code.
Bonus tip:
You can get a line back removing the declaration of things and placing it just after the out :
attributes.TryGetValue("varName", out string thing)

A: to set a default value of an nullable type in c# you can use the ?? opperator
if(nullableboolean ?? false){
}

so that would default to false

A: Something like this:
Dictionary<string,string> stuff = null;
if(stuff?.TryGetValue("key",out string val) ?? false){

   Console.WriteLine("hey");

}

redpajama_set_name: RedPajamaStackExchange


I tend to change my mind about which is my favourite piece of vintage fabric in my collection from week to week. Somehow or other I always come back to loving this fabric from Heals the most. It is called 'Flower Shop' and Hansjurgen Holzer designed it in the 1960s. As you'd expect from that era, it features a quintessential retro daisy/floral pattern.
It comes in a number of colourways, this version is made up of mustard yellows and olive greens on a pure white background.
I have made a number of totes and belts with this fabric, but it would equally make great cushion covers or handmade lampshades.
One of my all-time favourites too!


text:
24,483 reviews Write a review
The Royal Marsden Hospital (Sutton)
Downs Road, Sutton, Surrey, England, SM2 5PT
« ‹ 1 2 3 4 5 6 7 › »
Worries-concerns
The Royal Marsden Hospital (Sutton) 2020-01-02 Person 3 5 0
Review of Radiotherapy Sutton, written by a patient
All staff were attentive and caring. Changes of appointment were advised promptly as were minor delays in receiving treatment.
Rating not given.
The radiotherapy team members were welcoming, friendly and at all times thoroughly professional and efficient. Apologies and explanations were always given if appointments were running late (which was rare - mostly I was seen within a few minutes of my appointment time, which I found remarkable). I was treated with kindness and consideration. The fruit squash available at the water stations was a very welcome touch. Also loved the music - good to have something to listen to while endeavouring to lay absolutely still! When I was cold, a blanket was always available to me. It was also helpful to be given assistance to get up from the treatment bench. As someone with a long standing "back problem", and not as agile as I used to be due to advancing years, together with weakness from surgery and months of chemotherapy, trying to raise oneself from a prostrate position with arms that have "gone to sleep" having been raised above the head for the duration of the radiotherapy session is really difficult.
Review of Smithers Ward, written by a patient
I was treated by very friendly and reassuring staff who put me at ease despite my nerves, it really helped.
I consider myself extremely lucky to have been treated by the Head and neck team at both Fulham Road and Sutton over the years. They have always listened to me and given me every medical and emotional support I needed . Today I visited the Speech Therapy team and Sutton when I was seen by two very caring professional who carried out a detail examination of my swallowing issues using a magnificent new machine of which they were rightly very proud of . Thanks to both practitioners and their wonder machine I left there with a lot more knowledge and peace of mind than I had before that appointment. Many many thanks to The Royal Marsden and all who work there . xx
Review of Medical Day Unit (Sutton), written by a patient
I found the MDU to be very clean with up to date equipment and furnishings. The staff were knowledgeable, friendly and helpful and made sure that I understood what was happening and who to contact after I left the unit if I had problems.
The only issue was the person trying to give me a cannula. She struggled to fined a vein and did need to get someone else who got it first time but there was quite a wait...… not a criticism as such as there only appeared to be two nurses on at that time. All the staff were really friendly and helpful.
Everything was perfect. All the appointments were on time and everything was done professionally with perfection
Review of Admission and Pre-assessment Unit Sutton, written by a patient
I was treated with care, courtesy and efficiency by Siobhan in APU and Jackie in Physio. Thank you
I cannot rate the Royal Marsden in Sutton too highly. Their treatment of me was exemplary. All my 'more than 20' appointments were within 5 minutes of the scheduled time with one exception. In this case they were running 30 minutes late due to an emergency. However, they kept me informed so I knew what was going on. All the staff were friendly, pleasant and understanding. I was kept informed of what was going to happen and they answered any questions clearly.
Review of Bud Flanagan Ambulatory Care, written by a patient
Very good visit today. The new blood test system worked well. Doctor's consultation was excellent. I feel that I have been very well informed as to my progress.
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Short link to review The Royal Marsden Hospital (Sutton): http://iwgc.net/eb6aw

redpajama_set_name: RedPajamaCommonCrawl


text:
By gproyce
December 20, 2011 — 5:15pm
Dave Lee and Pete the Penguin. Photo courtesy of Museum of Broadcasting
Those who grew up around here in the 1960s likely recall Dave Lee, whose afternoon kids' TV show featured puppets Pete the Penguin, Omar the Alligator and Fragrant the Skunk. Lee died a few weeks ago in his California home, according to the latest newsletter from the Museum of Broadcasting. He was 86.
Lee was at Channel 9 from 1958-60 and then did several years at Channel 11, back when it was WTCN, in the 60s. The show went by several names but probably is best remembered as either "The Dave Lee Show" or "Popeye and Pete," when they were slinging Popeye cartoons. I always remembered it as "Dave Lee and Pete" although that was never the official name.
Lee had a live studio audience of kids and he and Pete (Lee's right arm) would introduce each one. Pete would pull girls' ponytails and boys' ties. Yes, in those days, if you were going on TV, you wore a tie.
The most memorable part of the gig was when Dave asked one lucky youngster to unpack the "Grab Bag" and tell the unfortunate kids stuck at home what goodies there were, and they were always the same: "Orange Drink, TV Times, Bonomo's Turkish Taffy...."
Lee left his show in 1970 and went to work fulltime in public relations and fundraising in Minneapolis and then in the Southwest and California. He lived for a number of years in San Diego and died in Westminster, Calif.
The best virtual entertainment this week: The Current's Sounds Like Home fest, 24 Hour Comedy Festival, Jonatha Brooke
Sounds Like Home Friday-Sunday: Don't feel guilty if you can't afford a virtual tip for this one: The musicians are actually getting paid. Yeah, go…
'Good Boys' trailer
LimelightPlayerUtil.embed({ "height": 321, "width": 540, "mediaId": "bb8a6e9945c541178157dac6d2cd7a25", "playerId": "limelight_player_427377", "playerForm": "LVPPlayer" });
Beer Bracket 18:Round 1-1
Which is your preferred brewery?
Minnesota Museum of American Art is homeless no longer
Minnesota Museum of American Art reopens after four years in temporary quarters in downtown St. Paul.
Tell us about an event


text:
Related Topics:Burna BoyFeatured
Burna Boy Vows To Never Come To South Africa
Babes Wodumo's Controversial Account Is Still Hacked
The new sensation is reaching for the stars.
Apple Music's New Artist Spotlight for December 2019 is Zimbabwean-born singer/songwriter Sha Sha with her debut release "Blossom".
Currently number 1 on the Apple Music Album charts, the melodic EP has a little something for everyone with its deft fusion of Afrobeats, Pop, Soul and Amapiano. "This EP showcases the versatility of my voice and touches on different themes," the 25-year-old singer reveals.
On "Blossom" Sha Sha provides a summer soundtrack which celebrates life's festivities and explores ideas of love and women's empowerment.
Assisted by production duo Kabza De Small & DJ Maphorisa as well as Samthing Soweto – who previously featured the artist on his number 1 smash hit "Akulaleki" – Sha Sha displays her songwriting abilities as well as her alluring vocals.
As the voice behind some of the year's other standout hits – including Mlindo the Vocalist's "Nge Thanda Wena," Scorpion Kings' "We'Mama" and MFR Souls' "Love You Tonight," Sha Sha has established herself as the go-to house music vocalist.
She gained in-studio experience from previously working with the likes of Don Laka, Rouge and Priddy Ugly. While effortlessly folding her diverse influences together, "Blossom" also shows the rapid growth of a singer who only begun her career in 2015 as part of a group called Blindfaith – something that might have never happened. "I wanted to be a nurse, actually. I used to sing in the choir at school but I never thought that it would be my career," the singer shares.
Much like paying homage to her hometown and the organic celebration of her Shona heritage on the rhythmic "Mutare," Sha Sha revisits her childhood by re-imagining house classics by Lorayne and Moloko.
"Something About You and Sing It Back are covers of songs I liked growing up. I added an Amapiano flavour just for the season and I love how they came out," she says. These reworks sum up Sha Sha's sonic appeal perfectly – her ability to apply the absorptive qualities of vocal house to the trending sounds of today.
By plotting a future for lyric based, vocally-driven Amapiano the Blaqboy Music signee rounds off a great year for Apple Music's New Artist Spotlight recipients.


"Explore the Outdoors" is the official field guide featuring outdoor activities in the Lebanon Valley. Visit Lebanon Valley was able to create the field guide with help from the Williams Atlantic Sunrise Grant program.
How can you explore the Lebanon Valley's wild side? Watch thousands of snow geese as they rest on their migration to the Arctic. Tour grasslands preserved for an endangered butterfly. Learn bouldering and climb an observation tower for a bird's eye view of the area. Take a canal tour through the oldest exisiting transportation tunnel in the United States. Enjoy a kayak trip down the Swatara Creek. From state parks to boke trails, outdoor music and entertainment, year-round activites, the Lebanon Valley is the place to explore your wild side.


What Does it Cost to Build a Closet in Washington, DC?
Get fast Closet Design quotes from Home Interior pros in Washington. Find out what your Closet Design project will cost and how much you can save by using the F2O price quote form.


text:
Article Commentary| December 01 2010
The First Structures of T Cell Receptors Bound to Peptide–MHC
Kai W. Wucherpfennig
Dana-Farber Cancer Institute, Boston, MA 02115
Address correspondence and reprint requests to Dr. Kai W. Wucherpfennig, Dana-Farber Cancer Institute, 44 Binney Street, Room D1410, Boston, MA 02115. E-mail address: Kai_Wucherpfennig@dfci.harvard.edu
J Immunol (2010) 185 (11): 6391–6393.
Kai W. Wucherpfennig; The First Structures of T Cell Receptors Bound to Peptide–MHC. J Immunol 1 December 2010; 185 (11): 6391–6393. https://doi.org/10.4049/jimmunol.1090110
The structure of the MHC class I molecule HLA-A2 reported in 1987 by Bjorkman et al. (1) had revealed how peptide Ags are presented to T cells: peptides are buried in the long and deep groove of the MHC molecule, flanked on each side by a long α helix. The structure immediately suggested that TCRs recognize the compound surface formed by the MHC helices and the embedded peptide (2), and a number of groups started to work on the extremely challenging problem of crystallizing a complex of peptide–MHC bound to a TCR. This quest was driven by several conceptually important problems. Among these, the most important question was how T cells recognize MHC despite the vast diversity within the T cell repertoire. Would there be a general binding mode of TCR on the MHC helices that explained MHC restriction, or would TCRs be able to bind to MHC proteins in many different ways? If a general binding mode indeed existed, how could it accommodate the vast repertoire of TCR sequences and the polymorphic nature of MHC molecules? In addition, would MHC class I and class II proteins be recognized in a similar manner? Thus, the goal of this effort was to provide a definitive molecular understanding for the concept of "MHC restriction", revealed by the elegant functional experiments of Zinkernagel and Doherty (3), for which both received the Nobel Prize in Physiology or Medicine in the same year these two structures were published.
Prior to publication of the HLA-A2 structure, only a few immunologists had anticipated the decisive contributions that structural biology was going to make to their field, but with this single structure it became crystal clear that protein structures could provide deep insights into intractable immunological problems. For noncrystallographers, it is important to appreciate that, with this type of work, you really have nothing in your hands, despite years of effort, until there are crystals that diffract to a sufficient resolution. The initial structure of HLA-A2 had been determined using protein purified from a human B cell line, and the groove therefore contained a complex mixture of peptides. In 1987, it was therefore not even known how a recombinant MHC protein with a single bound peptide could be generated. Furthermore, expression of soluble TCRs in quantities sufficient for serious structural work proved to be very difficult, even though clever approaches that yielded small quantities were reported. On the MHC side, it became clear that the MHC helices actually folded around the offered peptide and that it was impossible to generate stable, empty MHC class I molecules that could later be loaded with peptide. Years later, cell biological studies showed that nascent MHC class I chains become part of a peptide loading complex in the endoplasmic reticulum, in which the MHC class I molecule is held by chaperones in a conformation suitable for rapid peptide acquisition (4). Therefore, one solution to the MHC class I expression problem was to generate the molecules by refolding the MHC class I heavy chain and β2-microglobulin from subunits expressed in Escherichia coli in the presence of peptide. This approach, reported 5 y after the initial HLA-A2 structure, provided a reliable source of stable, single peptide–MHC complexes that crystallized on their own (5). A second solution was to express the MHC class I molecule in insect cells lacking components of the peptide loading complex and to culture these cells with the peptide of interest (6). The two groups also found different solutions to the TCR expression problem, either by refolding from individual chains expressed in E. coli or by expression in insect cells (7, 8). On top of these technical challenges in generating the two components, there was also the remaining question of whether the complex would indeed crystallize, given the low affinity and fast off rate for TCR binding reported by Mark Davis and colleagues (9). Clever photo-crosslinking approaches had been developed (10), but in crystallization trials, the protein concentration was far above the Kd of the interaction so that most TCR and peptide–MHC molecules would be expected to be in the bound state.
The two groups that succeeded in 1996 came well prepared and had laid the groundwork for this important advance. Don Wiley's group had determined the crystal structure of HLA-A2 in 1987 in collaboration with Jack Strominger's laboratory and later developed the E. coli approach to MHC class I refolding. Ian Wilson's group had determined the structures of mouse MHC class I proteins with bound single peptides from viral antigens in 1992, after having teamed up with Per Peterson's group, which had developed the approach for MHC class I expression in insect cells (6). The two structures of TCR–peptide–MHC complexes were published in short succession in the fall of 1996, the Garcia et al. paper (7) (Wilson laboratory) in October, and the Garboczi et al. paper (11) (Wiley laboratory) in November. The Wilson laboratory built on its early success with mouse H2-Kb and used the well-characterized 2C TCR with the low-affinity dEV8 self-peptide (12). The paper described in detail the structural features of the 2C TCR and then moved in the last figure to the most exciting result: the structure of the complex. The Wiley laboratory built on its work with the human HLA-A2 molecule and used a high-affinity antiviral TCR (A6 TCR) specific for a Tax peptide from HTLV-1, a human retrovirus associated with adult T cell leukemia and a chronic inflammatory CNS disease. The paper described many salient features of this complex, including the atomic contacts between TCR and peptide as well as MHC.
What do we see in these structures, or better, what do we learn? Both papers described a similar binding solution, a diagonal orientation of the TCR on peptide–MHC that buried most of the exposed surface of the peptide underneath the TCR footprint. This result was very exciting because these two TCRs were biologically very different from each other: They bound mouse versus human MHC, had a low versus high affinity for their peptide–MHC ligand, and recognized self versus viral peptides. The similarity in the overall binding mode, despite these biological differences, immediately suggested that this binding solution was probably general. Both papers reported that their respective TCR had a rather flat binding surface for peptide–MHC, and the Wiley group proposed a structural rationale for this general binding mode. They showed that the surface of MHC class I and class II molecules was actually not flat, but that there were two "peaks" near the N termini of the α helical regions. The diagonal orientation allowed the TCR to fit down between the two highest points of the MHC molecule so that it could make contacts along the length of the peptide. Prior work by Stan Nathenson's laboratory had suggested a diagonal TCR footprint based on mutational analysis of 59 antiviral T cell clones restricted by H2-Kb (13). The similar diagonal orientation in both structures, combined with these functional data, provided solid experimental support for the idea that this binding mode was general.
How do TCRs recognize the bound peptide? The diagonal docking solution positioned the most diverse loops of the TCR (CDR3α and CDR3β) over the center of the peptide. Such a result had been predicted because this organization would provide the greatest discrimination power for peptide recognition (14). In both structures, the CDR3 loops formed a cavity in the center of the binding surface, and in the A6 TCR structure this pocket was occupied by the central P5 residue of the Tax peptide (a tyrosine). The two CDR3 loops of A6 TCR made extensive contacts to the Tax peptide, contacting residues 4, 5 (CDR3α) and 5, 6, and 8 (CDR3β). The germline-encoded CDR1 loops of both chains also contributed to Tax peptide recognition, with CDR1α positioned over the peptide N terminus and CDR1β over the C terminus. Mark Davis' laboratory had earlier proposed that the TCRβ-chain was placed over the C-terminal part of the I-Ek–bound cytochrome C peptide, based on cleverly designed experiments with single-chain TCR transgenic mice (15).
What are the consequences of the diagonal binding mode for MHC binding? The diagonal positioning placed both CDR2 loops over the MHC helices, CDR2α over the MHC α2 helix, and CDR2β over the MHC α1 helix. It also allowed the CDR1 loops to contact the MHC helices as well as the bound peptide. Placement of the germline-encoded CDR1 and CDR2 loops over the MHC helices provided a structural solution for the biological problem of MHC restriction. The CDR1 and CDR2 loops were shorter and had less conformational diversity than did the CDR3 loops. The less diverse features of TCR were thus positioned over the MHC helices and the most diverse loops over the bound peptide.
After publication of these two papers, attempts were made to identify conserved MHC residues required for binding by all TCRs (16, 17). Even though some MHC residues were frequently recognized, entirely conserved TCR contact residues on MHC proteins could not be identified. Subsequent work by the Garcia and Kappler laboratories showed that all mouse TCRs that used Vβ8 and recognized I-A proteins showed very similar binding interactions of the germline-encoded CDR1 and CDR2 loops with the I-A α1 helix (18, 19). Mutation of key contact residues of the Vβ8 CDR2 loop greatly reduced thymocyte numbers in mice expressing such mutated TCRβ-chains, suggesting that these MHC contacts were important for T cell development (20). These results led to the hypothesis that individual Vα and Vβ domains have preferred binding interactions with MHC proteins because of the coevolution of individual V-genes with MHC (21).
Later structural characterization of MHC class II-restricted TCRs confirmed the general principles outlined in these two papers, even though MHC class II-bound peptides can exit the groove on both ends (22). The Wiley group used the accessibility of the peptide C terminus to develop a clever approach for production of stable MHC class II–peptide–TCR complexes (23). They took advantage of the long t1/2 of MHC class II-bound peptides and attached the peptide sequence to the N-terminus of the TCRβ-chain; stable complexes resulted from binding of the TCR-tethered peptide to the MHC molecule. This technique enabled structural characterization of autoimmune TCRs with low affinity for their peptide–MHC ligand (24, 25).
A large number of structures have now been determined that have dealt with important topics, such as immunodominance, autoimmunity, tumor immunity, and allo-MHC recognition (26). The Garcia et al. (7) and Garboczi et al. (11) papers deserve to be considered classics in immunology. They provided the structural explanation for MHC restriction, a phenomenon that had intrigued and baffled immunologists for more than two decades. They are testament to what can be accomplished by the right mix of excellence, good judgment, and persistence, with the little dose of good luck that is required for all crystallographic endeavors.
Disclosures The author has no financial conflicts of interest.
Bjorkman
Saper
Samraoui
Strominger
D. C.
Structure of the human class I histocompatibility antigen, HLA-A2
The foreign antigen binding site and T cell recognition regions of class I histocompatibility antigens
Zinkernagel
Doherty
Restriction of in vitro T cell-mediated cytotoxicity in lymphocytic choriomeningitis within a syngeneic or semiallogeneic system
Cresswell
Bangia
Diedrich
The nature of the MHC class I peptide loading complex
Immunol. Rev.
Garboczi
D. N.
HLA-A2-peptide complexes: refolding and crystallization of molecules expressed in Escherichia coli and complexed with single antigenic peptides
Matsumura
Crystal structures of two viral peptides in complex with murine MHC class I H-2Kb
K. C.
Brunmark
Teyton
An alphabeta T cell receptor structure at 2.5 A and its orientation in the TCR-MHC complex
Ghosh
VanTienhoven
Biddison
Assembly, specific binding, and crystallization of a human TCR-alphabeta with an antigenic Tax peptide from human T lymphotropic virus type 1 and the class I MHC molecule HLA-A2
Steffner
Reay
Kinetics of T-cell receptor binding to peptide/I-Ek complexes: correlation of the dissociation rate with T-cell responsiveness
Luescher
Anjuère
Peitsch
Jongeneel
Cerottini
Structural analysis of TCR-ligand interactions studied on H-2Kd-restricted cloned CTL specific for a photoreactive peptide derivative
Q. R.
Structure of the complex between human T-cell receptor, viral peptide and HLA-A2
Tonegawa
H. N.
Attachment of an anti-receptor antibody to non-target cells renders them susceptible to lysis by a clone of cytotoxic T lymphocytes
C. T.
Sheil
Nathenson
Evidence that the antigen receptors of cytotoxic T lymphocytes interact with a common recognition pattern on the H-2Kb molecule
Model for the interaction of T-cell receptors with peptide/MHC complexes
Cold Spring Harb. Symp. Quant. Biol.
Mapping T-cell receptor-peptide contacts by variant peptide immunization of single-chain transgenics
Gagnon
Identification of a crucial energetic footprint on the alpha1 helix of human histocompatibility leukocyte antigen (HLA)-A2 that provides functional interactions for recognition by tax peptide/HLA-A2-specific T cell receptors
T. C.
Schlueter
Brodnicki
Speir
Alanine scanning mutagenesis of an alphabeta T cell receptor: mapping the energy of antigen recognition
Structural evidence for a germline-encoded T cell receptor-major histocompatibility complex interaction 'codon.'
Huseby
Rubtsova
Scott-Browne
Marrack
Crossreactive T Cells spotlight the germline rules for alphabeta T cell-receptor interactions with MHC molecules
Gapin
Germline-encoded amino acids in the alphabeta T-cell receptor control thymic selection
The molecular basis of TCR germline bias for MHC is surprisingly simple
Reinherz
E. L.
Smolyar
The crystal structure of a T cell receptor in complex with peptide and MHC class II
Hennecke
Carfi
Structure of a covalently stabilized complex of a human alphabeta T-cell receptor, influenza HA peptide and MHC class II molecule, HLA-DR1
Pyrdol
Unconventional topology of self peptide-major histocompatibility complex binding by a human autoimmune T cell receptor
Quandt
Mariuzza
Structure of a human autoimmune TCR bound to a myelin basic protein self-peptide and a multiple sclerosis-associated MHC class II molecule
How TCRs bind MHCs, peptides, and coreceptors
Annu. Rev. Immunol.


text:
Karin Fransson, född den 16 mars 1951 i Weingarten, är en svensk kock. Hon var till och med 2019 köksmästare på Hotell Borgholm på Öland.

Karin Fransson är uppväxt i södra Tyskland men sedan 30 år verksam i Borgholm på Öland. Hon medverkade regelbundet i programmet Meny i Sveriges Radio.

Bibliografi
1998 Karin Franssons örtamat
2006 Meny – det bästa ur radioprogrammet
2006 En handbok örter (med Annica Triberg)
2007 Karin Franssons sju årstider – kärleken till de goda råvarorna

Utmärkelser
1989 Gastronomiska akademiens diplom
1992 Lilla sällskapets diplom och matsked
1992 Årets ölänning
1995 Cajsa Warg-stipendiet
1997 Gastronomiska akademiens guldmedalj
2000 Gastronomiska akademiens Scanstipendium
2001 Gyllene pumpan

Se även
Sven Ekberg

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Playing goalie in lacrosse is one of the hardest positions to play in any sport. Wearing minimal padding and having offensive players firing a ball at you upwards of 80 mph doesn't make it any easier. For Fairfield University Men's Lacrosse goalie Tyler Behring '17, this has become a cake walk. Behring's .572 save percentage and 11.71 saves per game from last season were ranked top 10 in the country. His 9.19 goals against average and 199 total saves in a single season both ranked 7th all-time in program history. I sat down with the goalie from Little Silver, N.J. to discuss a wide range of topics.
A: I usually listen to the song "Shipping Off to Boston" right before I play to get me in the zone and get me excited.
Q: On the contrary, do you have any in-game superstitions? I know I've seen a lot of goalies hit the pipes with their stick when they are on the field.
A: I do hit the pipes. I do a triangle (left, right and above my head) a couple times in a row.
Q: Do you have any hidden talents that no one knows about?
A: That's a tough one. I can crack my jaw, which is kind of weird. Not many people can do that.
Q: What were your thoughts on being named to the Preseason All-New England Team?
A: I was definitely happy about it, but I try not to think about it going into the season because I feel like it puts pressure on you to do well. I try and just let it go and just play my game.
Q: You had nine saves in a tough loss on Saturday against Richmond, what adjustments does the team need to make moving forward?
A: I think we just need to work harder in practice and pay attention to the small details in order to get things back on track. I think this week we have really done a good job of starting to do that. Hopefully we can continue that.
Q: When did you first want to play goal and why?
A: It actually started in 7th grade. Our goalie quit for our team and I played defense. Everyone looked at me and I was like, alright I'll try it. I ended up really liking it and stuck with it through high school.
A: First and foremost, getting the team back on track and getting our first win of the season under our belt. That way we can build confidence and hopefully that will lead us to making the tournament and winning the [Colonial Athletic Association].
Q: What would you like to do after Fairfield?
A: If I were to get drafted (in the Major League Lacrosse Draft) that would be great; I would probably give it a shot. I would not be discouraged if I didn't get drafted or didn't get to play in the MLL. I think I've definitely had a good four years here so we'll see.


text:
Melaleuca tinkeri is a plant in the myrtle family, Myrtaceae and is endemic to the south-west of Western Australia. It is one of the smallest melaleucas and is distinguished by its warty, hairy leaves, heads of pinkish flowers in late winter to spring and its spherical fruiting clusters.

Description
Melaleuca tinkeri is a shrub rarely growing to more than  tall. Its leaves are arranged alternately and are  long,  wide, linear to narrow egg-shaped with the narrower end at the base. The younger leaves are covered with soft, silky hairs and the oil glands are raised, giving the leaves a warty appearance.

The flowers are pinkish to purple and are arranged in heads on the ends of branches which continue to grow after flowering and sometimes also in the upper leaf axils. The heads are up to  in diameter with 4 to 12 groups of flowers in threes. The petals are  long and fall off as the flower matures. The outer surface of the floral cup (the hypanthium) is hairy and there are five bundles of stamens around the flower, each with 3 to 6 stamens. Flowering occurs from July to October and is followed by fruit which are woody capsules,  long, packed tightly together in spherical or oblong clusters.

Taxonomy and naming
Melaleuca tinkeri was first formally described in 1999 by Lyndley Craven in Australian Systematic Botany from a specimen collected  east of Eneabba. The specific epithet (tinkeri) honours Allan Tinker for his knowledge of the flora of the Eneabba area.

Distribution and habitat
This melaleuca occurs in the Nandanooka and Lesueur National Park areas in the Avon Wheatbelt and Geraldton Sandplains biogeographic regions. It grows in shallow, gravelly sand over laterite or granite.

Conservation
Melaleuca tinkeri is listed as "not threatened" by the Government of Western Australia Department of Parks and Wildlife.

References

tinkeri
Plants described in 1999
Endemic flora of Western Australia
Taxa named by Lyndley Craven


We can repair boards for most modern games (1990). Our fixed price scheme gives you the costs before the board is sent to us, however, we now charge £20 + VAT if there is nothing wrong with your board for the time it takes to test and repack etc.
ALL PRICES IN ADDITION TO COST OF PARTS USED.
We can repair boards for most modern games (1990) usually within 24 hours, our fixed price scheme gives you the costs before the board is sent to us, however, we now charge £20 + VAT if there is nothing wrong with your board for the time it takes to test and repack etc.


text:
Twitter Shareholder Sues Elon Musk for Stock Manipulation
Scott May 27, 2022
Since Elon Musk sought to acquire the microblogging network, the Twitter-Musk scenario has been the talk of the town. Following the acceptance of the $44 billion deal, we've witnessed …
Elon Musk's $44 billion Twitter deal faces 1st legal hurdle in US
Scott May 7, 2022
The Orlando Police Pension Fund has filed a lawsuit against Elon Musk and his $44 billion takeover of Twitter, alleging that the transaction would not conclude until 2025 due …
Twitter for Android Is Reportedly Working on Mixed Media Tweets; Multiple New Features
Twitter is available for Android and is believed to be developing a variety of brand new functions, such as support for uploading videos and images on the same Tweet. …
Facebook Said to Discontinue Nearby Friends Feature, Weather Alerts, More
Facebook's Nearby Friends feature, which allows users to communicate their current location to other Facebook users, will cease to be accessible from May 31 of this year. According to …
FTC is investigating Elon Musk's purchase of a Twitter stake
Scott April 29, 2022
A report from The Information on Thursday said that the Federal Trade Commission is looking into Tesla Inc. CEO Elon Musk's first 9 percent stake purchase in Twitter Inc. …
Do you want to delete your Twitter account? This is how to do it.
Twitter, the microblogging service that Tesla CEO Elon Musk wants to buy, lets people share various content. Unique films, photos, and memes can be found on the site. Furthermore, …
Twitter introduces a 'poison pill' in response to Elon Musk's takeover attempt.
Twitter's board of directors said Friday night that the "poison pill" protection would be used to stop Tesla CEO Elon Musk from taking over the company. In the wake …
Snapdeal CEO shares viral WhatsApp message: 'Ceylon Musk might buy Sri Lanka.'
Several memes and jokes have been made about Elon Musk's $43 billion offer for Twitter. One group of people was shocked to learn that the huge sum could wipe …
Elon Musk is accused of breaking the law when he bought Twitter stock.
Musk's huge Twitter investment took a new turn on Tuesday when a lawsuit was filed that said the billionaire illegally hid his stake in the social media company so …
Agrawal says Elon Musk will not join the Twitter board.
Tesla CEO Elon Musk has decided not to join Twitter's board of directors. The CEO of Twitter, Parag Agrawal, says this is true. Agrawal said in a statement that …


text:
Interview with Sally Slate
Richland (Wash.)
Kennewick (Wash.)
Hanford (Wash.)
Hanford Site (Wash.)
Nuclear weapons plants--Health aspects--Washington (State)--Hanford Site Region
An interview with Sally Slate conducted as part of the Hanford Oral History Project. The Hanford Oral History Project was sponsored by the Mission Support Alliance and the United States Department of Energy.
Hanford Oral History Project at Washington State University Tri-Cities
Those interested in reproducing part or all of this oral history should contact the Hanford History Project at ourhanfordhistory@tricity.wsu.edu, who can provide specific rights information for this item.
2016-07-19: Metadata v1 created – [J.G.]
The Hanford Oral History Project operates under a sub-contract from Mission Support Alliance (MSA), who are the primary contractors for the US Department of Energy's curatorial services relating to the Hanford site. This oral history project became a part of the Hanford History Project in 2015, and continues to add to this US Department of Energy collection.
Oral History Item Type Metadata
Robert Bauman
Sally Slate
Washington State University - Tri-Cities
Robert Bauman: Say your name and spell your last name for us?
Sally Slate: Okay. Sally Slate. S-L-A-T-E.
Bauman: Okay. My name's Robert Bauman and today's date is August 5th of 2015. We're conducting this interview at Sally Slate's home in Richland, Washington. So let's—if we could, start by having you give us some background information on when you came to the Tri-Cities, what brought you here?
Slate: Well, I was a new graduate from the University of Idaho in June of 1955. I guess I was attracted to this area because I was going with a young man that still had a couple of years of schooling, and I wanted to be kind of close to the University of Idaho for him. Unfortunately, we broke up. [LAUGHTER] But I came as a tech grad for GE. These were three-month assignments where we rotated different assignments. My first assignment was to open up the chemistry lab at PUREX building that was still under construction.
Bauman: And were you familiar with Hanford before you came here? Did you know much about the place?
Slate: Yes, I was, because we have an atomic energy site near southern Idaho, and my father was working there. So I was quite well-informed. In fact, I'd taken some classes in nuclear energy.
Bauman: And had you been to Richland or the Tri-Cities before?
Slate: No.
Bauman: And did you have a first impression when you arrived?
Slate: Well, everybody had told me that I was going to hate it, that it was desolate, sagebrush. I came here and I thought, gee, I'm at home! Snake River's just around the corner. And [LAUGHTER] sagebrush, I'm well-acquainted with. Potato fields? Yes. And also, I felt very comfortable.
Bauman: So you said your first job was opening up the chem lab at PUREX.
Slate: Yeah.
Bauman: Can you describe what that was like? What that work was like?
Slate: It was doing a lot of dish-washing. Because everything had to be taken out of the boxes, we had to figure out where to put it in the lab, we had to get the equipment set up and tested. There were two or three of us doing that job.
Bauman: And can you maybe explain what PUREX was, for [INAUDIBLE]?
Slate: PUREX is the separations plant that was—the fuel went in on one end of the building and made a continuous run and we got the plutonium and uranium separated at the end. The REDOX Plant, you had to do it in batches. But this was a continuous process, so it was going to be a little more efficient. As I say, it had not been—they were still under construction at the time that I was out there. And unfortunately, when we got here, nobody had Q clearances, and they thought that we needed Q clearances. So they set us in the unclassified library until they finally figured out that, oh, our clearances are all sitting on somebody's desk and he's on vacation, and you don't need a Q clearance anyways, so put them to work! [LAUGHTER]
Bauman: So that was your first job. Where did you go from there?
Slate: Oh. The next job was at the REDOX Plant. It was not really a happy experience. I wanted to be in the lab. As a woman chemist, I don't think they appreciated women chemists in the lab at that time. It was trying to put together a compilation of all of the procedures that were being done, and trying to classify them so that if we got some kind of an assignment, you had to—okay, we need this analysis done. What procedures do we have available to do it? And it was well before the capabilities of our computer systems and everything now. I just didn't appreciate that assignment. Then I went into the classified library as an abstractor. Where I had to read all of the classified—we were one of four—reading classified materials that came in. Everything from books to reports and anything generated that came into the library. We had to write a small paragraph about what the—without saying anything classified. We did bibliographies, computer searches. Except it wasn't a computer search, it was a search of the index cards and made up answered questions that would come in. That was an interesting job. But it wasn't as fun as being in the lab.
Bauman: And how long did you work there in the classified library?
Slate: Well, that was pretty much—well, that was a permanent position.
Bauman: Oh, okay.
Slate: I worked there until I had been married and was expecting a child. And then they required me to quit.
Bauman: Okay. So you talked about being a woman chemist and it didn't seem like you were really welcome in the lab, or that they wanted—were there other women chemists around at the time?
Slate: There were a few. There was a couple of others. Actually—let's see. I'm thinking as the abstractors, the other chemist who was an abstractor was a mathematician. And the other woman was a mathematician. They were drawing the abstractors from the scientific fields, because you could teach somebody to be an abstractor, but you couldn't teach the scientific part of it as easily.
Bauman: Right. So was it a GE policy that when you were married and—
Slate: Yes.
Bauman: --you had to quit?
Slate: Yes. Five months, period.
Bauman: Oh, you had five months after you—
Slate: After you got pregnant.
Bauman: After you got pregnant, that you could work and then you had to quit.
Slate: That was routine. When I got to working in Idaho for Argonne National Lab, they said I could I work as long as I wanted. As long as I could do the job. Phillips Petroleum says, we think you're pregnant. Prove it that you're not. Otherwise, you're gone. There's definite bias there.
Bauman: Oh yeah.
Slate: They didn't want us riding the bus.
Bauman: Okay.
Slate: And I was riding a bus 75 miles each way. Twice a day.
Bauman: Do you know when that policy changed?
Slate: I don't. Because my next experience out here was in the '70s. And by that time, the policy had changed.
Bauman: Sometime in between there.
Slate: Sometime in between.
Bauman: Yeah, it changed. So let's talk about transportation. You said you had to ride a bus out?
Bauman: Pretty much every day?
Slate: Here in Richland, we had the buses. They would pick up at specified places along the—in town. Or you could drive your car out to the big bus lot, and leave your car there and transfer to the bus that you were going to be going out into the Area on.
Bauman: Okay. And where was the lot at?
Slate: Oh, go out Stevens, on the left-hand side as you go out Stevens.
Slate: They've transformed it into—part of it was an area where the police are doing training. After they had just redone the parking lot and spent millions doing the parking lot, then they decided, oh, we'll close the buses down. [LAUGHTER]
Bauman: I wanted to ask you about housing when you arrived in Richland. What sort of housing was available, or wasn't available?
Slate: Well, when you first come, you check into the Desert Inn, which was the only hotel in town. Then you check with the Housing Authority, and the housing office assigns you housing according to your job, and your status—your marital status. And being single, I was assigned to one of the dormitories. And we still see the dormitories around. W-5 was just off of Lee—Lee and Knight. It was definitely a dormitory. It had a house mother. Doors were closed on the weekdays at 10:00 at night. The doors were locked. It was later than that for the weekends. But you had a little room, furnished. If you took the furniture out and put your own furniture in, you couldn't get their furniture back if you changed your mind. It was cheap.
Bauman: Do you remember how much it cost?
Slate: I don't. But something--$20 a month or less.
Bauman: And so how long did you stay in the dorm then?
Slate: I stayed in the dorm until—well, I went into a private apartment with a friend. And then we got married and went into a two-bedroom prefab down here.
Bauman: Oh, okay, sure.
Slate: In the south end of town. When those houses went up for sale, we could have bought that house for $1,875. [LAUGHTER] Yeah. We thought it was too small for us, because by then we had two small children. We bought a pre-cut. Three-bedroom pre-cut from a friend. They didn't want the house, but if they had just moved into the house that they were going to buy, they would have had to remove all of the improvements that they'd put into the house, which included the wall-to-wall carpeting, drapes, electrical for a dryer, a fenced-in backyard. All of that would have had to have been removed. And they would have lost all of that investment. So they bought the house and sold it immediately to us at a slightly higher price to accommodate for their investments.
Bauman: How would you describe Richland in the '50s? I know it was a government town, still, when you—
Slate: It was government town, yeah. Everything. The schools were—GE ran it all for the government. Police department, schools—just about all of the—anything that had to do with the town.
Bauman: And did that change significantly when it sort of became its own city, then?
Slate: It was very gradual. They started selling the houses—we became a town in October of '57? '57. And the houses were being sold in '58. Early '58, we bought our house on Smith.
Bauman: I know one of the events from the community happenings or things was when President Kennedy came to visit in 1963. Were you here then?
Slate: '63, we were not.
Bauman: Oh, had you—
Slate: We had left. Took a while to wander around to Idaho and Washington, but kept coming closer and closer, and finally said, we got to go home.
Bauman: You talked about having to get a—well, you thought you had to get your Q clearance, then didn't have to get a Q clearance. What was security like at Hanford at the time? Would that impact your work—I mean you were working in classified libraries, so that part--
Slate: Yeah. You could get into—up to the 300 Area. But there was a barrier there. You couldn't go through the barrier without a clearance. You had to have at least a Q clearance—or not a Q clearance, a Nil clearance is what they called it, was the beginning clearance. But then to get into the 200 Area, and to get into Two West, you had to have a Q clearance. That was just—you had a badge and it had your type of clearance on it. If you were working around the areas where there was a lot of radiation or potential radiation, then you'd wear pencils, and you might wear a ring. The ring would be checked weekly, and if it showed anything, then they would check your badge. Badges were changed out, I think, on a monthly basis. I never was in a situation where I accumulated anything. You had hand and shoe counters that you had to check into the building and check out of the building—using the hand and shoe counters to make sure you weren't carrying anything there. Because those would be the two areas that would be most apt to pick up something.
Bauman: So where was the classified library located?
Slate: In the 300 Area. The building is still there. I don't remember the building number. It was across from 319.
Bauman: And you mentioned—so you got married in—
Slate: In March of '56.
Bauman: Okay, and did your husband also work at Hanford then?
Bauman: And what area did he work in?
Slate: He was at Three West Area. The REDOX area.
Slate: We happened to be riding the same bus together.
Bauman: Is that how you met?
Slate: Actually, we met at the Mart cafeteria. That building on Lee and Knight that has Sirs and Hers Barbershop and had a gun shop in there. But at that time it was a 24-hour cafeteria. There was a drugstore in part of it. And there was a jewelry store up front and a little lounge area, the Evergreen Lounge, in the back. We'd just—I'd just gotten off of my first day of swing shift.
Bauman: Oh.
Slate: And he had just gotten off work. We were in there having coffee. The girl I was with knew him, and knew the other fellow that he was with. But then I discovered that we rode the same bus. Or, rather, I made sure we rode the same bus. [LAUGHTER]
Bauman: So how was Hanford as a place to work, then? I know you talked about not really being able to work as a chemist [INAUDIBLE]
Slate: Well, I don't think it was any different than working anywhere else at that time. Because there were restrictions everywhere. My original plan when going to college—I wanted to be a veterinarian. And after one year of pre-vet being the only girl in the School of Agriculture, I was told there was no way in hell that a woman would be accepted into the School—
Slate: --of Veterinary Science. And that I needed to choose something else. So, I went into chemistry, which is another love that I had. I was one of two women—first two that had graduated in chemistry in five years from the University of Idaho. And now, you know what percentage of women are. Far more women than men. And the same veterinary school now.
[PHONE CHIMES]
Bauman: Sorry about that. Talking about Richland, I was going to ask you one other question about the town. In terms of entertainment or things to do for fun, what was there in the area in 1955, '56?
Slate: Well, pretty much the same things that we have now. The Richland Players was a movie house at that time. The roller skating rink was there. We could ride horses—we could rent horses out on Van Giesen. Boating. Pretty much the same mix of things that we have now. At that time, we had the symphony, we had Richland Players, although they were having their plays in the schools at that time. But those were the things—and bowling.
Bauman: So when did you move away from Richland, and when did you come back then?
Slate: Oh. We left in '58, '59. We left in '59—June of '59. And we came back for good in '71.
Bauman: Had the place changed a lot in that time?
Slate: Grown! Yes. Not so much Richland. Although it was beginning to grow. But the areas between Richland and Kennewick that used to be grapevines and all kinds of farmland where Columbia Center was getting started and it just—I didn't know my way around.
Bauman: [LAUGHTER] Are there any things I haven't asked you, or anything you'd like to talk about that you haven't had a chance to talk about yet, in terms of your work at Hanford, or--?
Slate: At Hanford? Of the early years?
Bauman: Yeah!
Slate: I don't know. I enjoyed it very much. It was very mentally stimulating. And even the recreational things that were here were—because we had the symphony, we had the Richland Players. And it's good to see that they are growing. If we'd only get our performing arts center.
Bauman: I'm with you on that. [LAUGHTER]
Man three: We're with you.
Slate: And they're saying 20, 30 years, and I don't have that many years left, I'm afraid.
Bauman: Well, I want to thank you very much for letting us come to your home and interview you, talk to you. I appreciate your sharing your experiences with us very much.
Slate: Well, it's been kind of interesting, thinking back to those days.
Man three: I had a quick question, comment.
Slate: Yeah?
Man three: So when you were in the labs—
Man three: What would you do? What were you doing in, like the PUREX or the—what sort of thing would you do?
Slate: Oh. Well, the laboratory was an analytical lab. And they were divided into hot sections and cold sections. The hot section would receive the really radioactive materials that had to be handled in big glass-enclosed, with lead—a glass so wide. But I was never involved in that real high level. By the time I got things, it was down to the very low level radioactive materials that we could handle in a hood with ventilation. We wore just a lab coat. I'm trying to think if we even, in those days—I don't think even at REDOX that I was involved with anything higher than just very low level materials. And we would separate out the plutonium or the uranium out of the fraction that we got, and would pipette it onto steel planchets. Little steel discs. And then the discs would go downstairs to the counting lab, and would be put into the counting lab and they would determine how many counts per minute were coming off of that. That would tell them the amount of radiation that there was, the amount of material that there was in that. We did everything in duplicates and triplicates, to make sure that we hadn't made a mistake.
Bauman: Right.
Slate: Most everything was done triplicates.
Man three: So you didn't work in the hot cells because of gender?
Slate: No, no. I didn't work in the hot cells because I didn't work in the—I was never assigned to it.
Man three: But that wasn't a gender-based—
Man three: I was trying to—
Slate: No, I don't think it was gender-based at all.
Man three: The other question I had was—so, GE and stuff, if you were five months pregnant, then that was the time to separate.
Slate: Yep.
Man three: Did you have a job to come back to, or that was terminated?
Slate: [LAUGHTER] You had a job to come back to if there was a job available. That was part of the reasoning, they said, oh, that going into the classified laboratory was perfect for you, because there'll always be a job available. Little did they know that computers were coming along, and computers were going to do all the abstracting and all the bibliography. You'd punch in a question and they'd come out with all the answers of here's the materials that we have available on that subject. So computers did away with that job.
Bauman: Right. Had your old job been available, would you have had it, or would you have had to reapply?
Slate: I would have had to reapply.
Bauman: Yeah, that's what I was thinking.
Slate: Yeah, it wasn't an automatic thing.
Slate: You were expected, as a young married mother, to stay home with your children. At least until they got into school. That wasn't to say that there weren't people who went back to work right away. But it was not the usual thing. Of course, I wanted to be able to stay home with the kids. By the time I had three, I had to go to work. [LAUGHTER] By that time, I started looking around and thinking, well, what can I do? I can go back to school and get a job as a teacher. So I got my teaching degree. And I taught school for five years until we decided we got to go home, we got to come back here to Richland. And that's when I got back into the chemistry.
Bauman: All right, well, thank you again very much.
Man three: Thanks.
Bauman: I really appreciate your time and letting us come in here. [LAUGHTER]
Man one: Okay.
Bit Rate/Frequency
Hanford Sites
300 Area
Reduction-Oxidation Plant (REDOX)
Plutonium Uranium Extraction Plant (PUREX)
Years in Tri-Cities Area
Sally Slate passed away on July 26, 2017.
Names Mentioned
Kennedy, John F. (John Fitzgerald), 1917-1963
Post-1943 Oral Histories
200 Area& 300 Area& Hanford (Wash.)& Hanford Site (Wash.)& Kennedy, John F. (John Fitzgerald), 1917-1963& Kennewick (Wash.)& Plutonium Uranium Extraction Plant (PUREX)& Reduction-Oxidation Plant (REDOX)& Richland (Wash.)
Hanford Oral History Project at Washington State University Tri-Cities, "Interview with Sally Slate," Hanford History Project, accessed January 26, 2023, http://hanfordhistory.com/items/show/44.


text:
Мохамед Еіса Ісмаїл Дахаб () — суданський дипломат. Надзвичайний і Повноважний Посол Судану в Україні (з 2018).

Життєпис
У 2003 — заступник посла, повноважний міністр Посольства Судану в Кампалі, Уганда.

У 2010—2014 рр. — Надзвичайний і Повноважний Посол Судану в Аккрі, Гана.

З 2017 — Надзвичайний і Повноважний Посол Судану в Києві, Україна.

10 січня 2018 року — вручив вірчі грамоти Президенту України Петру Порошенку.

Див. також
 Посольство Судану в Україні

Примітки

Суданські дипломати
Посли Судану в Україні
Посли Судану в Гані


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Which is why I'm writing to you today. I'll show you how to get the kind of forecasting weapons the wealthiest traders in the world have.
Only, I'm not giving you a mere weapon – I'm giving you the nuclear option. And you're going to use it to multiply your wealth like a Wall Street trader for explosive profits.
More importantly, it has, perhaps, the most advanced pattern recognition system in the world… And it uses weird-sounding things like sinusoidal waves and Fourier Transforms.
But, like I said, all you need to do is click your mouse a couple of times… and out pops a high-probability, 90-day trend forecast for almost any ETF, stock or index in the market today.
I know how accurate the science is. So does Wall Street… why else would Bloomberg license parts of my technology to put on over 330,000 terminals worldwide?
My name is Mike Turner. With my TurnerTrends Tools, I've created millions in wealth for myself and my followers by giving them stock forecasts as far as 90 days into the future.
Today, I'm going to show you how to use TurnerTrends Tools to forecast future pricing trends — with laser-like precision — for massive profits..
Make Money Like the World's Top Traders!
You get three different systems in one… telling you the directional trends for nearly every stock, ETF, or market available today.
Find the ideal stocks and ETFs that are going to make you the most money.
How can you pick from over 6,000 stocks and ETFs… just like the big investors do?
I start by narrowing it down to this week's 100 top stocks… OR the top 50 ETFs… courtesy of the ranking technology of TurnerTrends' Stock and ETF Forecaster.
When you click on one of the ticker symbols in Column #2, you get a chart that forecasts directional trends 90 days into the future for that stock.
The real key here is looking at the "First Trend". In time-cycle analysis, the trends that are the closest to you in time are going to be the most predictive in nature.
Below is an example of one of my hot entertainment stocks. Between the two arrows is the "forecast" part of the chart.
According to my system – and the massive amount of data it compiles every week – the trend for this play indicates a potential 25% gain over the next 90 days.
Does that mean those profits are locked in? Of course not.
However, if my system tells me the trend for this stock will continue to rise, I listen. Because, over time, that's proven to be my best way to make money from rising shares.
But plunging stocks can pay you oodles of cash, too.
Giving us a great opportunity to bank returns up to 24% in the next 3 months by shorting the stock.
The fundamental score quantifies how good (or bad) the company's financials are, while the technical score conveys how strong the timing is for buying or shorting.
If you really want to drill down deep… in addition to the weekly overall ranking of that stock or ETF, you can find its ranking within its sector, and its ranking in its industry.
This information is the most comprehensive trade-timing tool in the world.
Remember, these "Top" stocks and ETFs are the cream of the crop, picked from thousands on the major exchanges.
And it's recalculated and updated each week for each stock or ETF.
Imagine: Just with this one page, you can make boatloads of cash. It gives you everything you need to position yourself for high-profit trading trading, because once you know where a stock or ETF is likely to trend, you'll have the amazing ability to pick the best time to buy-and-sell.
That's why I've made the Stock and ETF Forecaster the heart of my system, a cornerstone of your scientific wealth-building, because there's nothing quite like a high mathematical probability to predict how a stock or ETF is likely to trend in the immediate future.
Remember, my system has over 2.8 million lines of software code, with quantitative math equations, and perhaps the most advanced trend-forecasting algorithms in the world.
With my patented stop-loss formula, you'll know how and when to slash your risk before you even enter your trade.
However, there are many other things TurnerTrends Tools does.
My system can also forecast the near-term directional trends for markets worldwide!
And I call this part of my system the Market Forecaster. Just like my Stock and ETF Forecaster, it's based on an array of mathematical formulas, any one of which might take hours to write out by hand.
The amount of raw data it crunches on a weekly basis is astounding. Yet, it hands you all you need to know about each market in one simple chart.
The chart above shows the S&P 500 from February 2017 to the third week of August 2017.
Let's take a closer look at the forecasting part of this chart.
Taken from the right side of the chart above, the red area shows when the market for this index is forecasted to be bearish. The green area shows when the market is forecasted to be bullish.
So, when this chart was created in the third week of August 2017, the market was forecasted to be bearish for the next two weeks. Then, it was forecasted to be bullish through the first week of October, and bearish for the rest of this year.
Do you think that doesn't help in deciding when to get in or out of that market?
The top line reflects the best possible directional trend for this index over the next 90 days.
The blue line in the middle is where my system is forecasting the market to go.
And the bottom line reflects the worst that index could do in that time.
So, let me ask: How much money could you make if you knew the directional trends for the Dow, S&P 500, or the NASDAQ over the next 90 days?
How about the price direction of a stock, gold, silver, or oil?
Remember, you not only get 90-day forecasts of these… you get 90-day forecasts of sectors, futures, forex, currencies… even countries with Market Forecaster.
It's the perfect complement to the Stock and ETF Forecaster, because they all tend to verify price direction with each other. And if there's one thing pro traders crave, it's verification.
All 3 together are the next best thing to having a crystal ball.
It may seem like my system's magical because of the way it uses decades of data to calculate the highest probability of directional trends for any market, stock or ETF.
This kind of advantage can give you the financial freedom to dream as big as you want.
All of these things are possible when you can forecast the direction of the market, ETFs and stocks for the next 90 days.
You'll have a much higher probability of picking which stocks will likely move in your direction, giving you a far better chance of getting into the right stock at the right time, and, more importantly, getting out at the right time.
You'll never be unsure where to invest ever again. Even (Especially!) in a down market.
Remember, Bloomberg licenses a portion of my TurnerTrends Tools for their $24,000/year Bloomberg Trading Terminal… more than 330,000 machines world-wide.
But you need to experience the total package for yourself. This is truly something you need to lay your hands on to see the amazing kind of profits you can produce.
And I'd like you to try my tools, at no risk to you.
TurnerTrends Tools… Made up of the strongest wealth-building tools available today: Stock Forecaster, ETF Forecaster, and Market Forecaster…These pro-level tools give you the power to see tomorrow's prices for stocks, ETFs, Indexes, commodities, currencies, and more.
TurnerTrends Tools List of Top 100 Stocks & Top 50 ETFs… A fast and simple way to get started, these are the hottest stocks and ETFs right now, updated every week.
Your Custom Risk-Eliminating Strategy… My TurnerTrends Tools trademarked stop-loss is designed to tell the difference between normal volatility — which means your stock drops temporarily — or whether it's taking an actual dive and you need to get out. No more expensive "nuisance stops." And your winnings are safely locked in.
Proprietary Screener… My stocks and ETFs get ranked through a rigorous screening. Now, you too can use the same screener I use to scrutinize over 6,000 stocks and ETFs. My high-powered bank of back-end computers will push it through my rigorous formulas, and rank it for you.
Weekly Updates…You'll never invest alone as a member of TurnerTrends Tools. I keep in touch with you, every week, with the latest research and market analysis. You'll get critical intelligence on where over 6,000 stocks and ETFs are… and where they're going… so you can stay in step with the brightest and best on Wall Street.
V.I.P. Access to Our Private Website…You'll find all the tools, training videos, market commentary, and TurnerTrends Tools'unique outlook on the markets. These insights alone are worth the price of admission.
Truly, TurnerTrends Tools eliminates guessing what to buy and sell – or when to do it – and replaces it with KNOWING when to do those things.
Some people pay way too much money… just to make money.
Joining an exclusive Hedge Fund may cost you 2% of your total assets as a management fee… and 20% commission on your wins.
Using private trading rooms led by has-been gurus can cost upwards of $10,000 a month… and you usually have to know someone to get in.
High-end "trading signal" services, led by even more washed-up gurus, can cost you $5,000 a month.
Exclusive newsletters and trading advisories can run up to $4,000 a year.
Knowing that TurnerTrends Tools gives you the potential to beat any of the above, you may think that I charge a fortune to be a member… and perhaps I should!
…starting with TurnerTrends Tools: Three of the strongest wealth-building tools available today… the Market Forecaster, the Stock Forecaster, and the ETF Forecaster… my Top 100 Stock picks and Top 50 ETFs, updated every week… access to my white-hot screening tool and its database of more than 6,000 stocks and ETFs… and V.I.P Access to TurnerTrends Tools' private website.
Yet, for the next 72 hours, you only pay a generously discounted $995 for one full year of TurnerTrends Tools… a savings of $1,000.
Or, for an even better deal, you can subscribe for two years for only $1,695… bringing your entire savings to $2,295!
And continue to sit on the sidelines in fear. You can worry about every penny you could lose, and every opportunity you will lose, when the market makes a big move and you miss out.
You can fear outliving your money, having to choose someday between being dependent on your kids — or the government — or being broke and alone.
But, for anyone over 40, living in fear is a one-way ticket to the poorhouse… because taxes, a shrinking dollar, and medical bills will steadily eat away at your savings… while living in fear will stop you from taking reasonable chances to grow your wealth to last a lifetime.
Instead of giving in to fear, you can take a 30-day test-drive, a no-risk trial membership, where you can join our community of successful investors at TurnerTrends Tools.
I'm going to remove all risk from you and place it on my shoulders. I'm going to make sure you are protected with my unique Zero-Risk Guarantee.
…Because you MUST be COMPLETELY DELIGHTED with TurnerTrends Tools. Or I will RUSH you an immediate full refund. Every cent.
No questions asked. No worries.
You must agree TurnerTrends Tools meets or exceeds your expectations in every way.
If for any reason — any reason at all — you wish to cancel in the first 30 days, I will INSIST you accept an immediate and full 100% refund.
And no matter what, you get to keep all of your wins and any website downloads with my compliments.
This means you have no risk. There is nothing to lose.
So, please don't hesitate — not even for a second. Join TurnerTrends Tools now before this offer times out.
Your enormous savings could be gone and you may have to pay full price.
Yet, my 100% guarantee means you can try it out at the discounted price… and get back every cent if you like.
I think you'll agree… this is an offer you can't afford to miss.
But the clock's ticking. There's no reason not to give it a try when it's completely risk-free.
Claim your 30-day test-drive now while there is still time!
P.S. Please — six months from now, I don't want you to be beating yourself up, knowing what could have been. Click the button below to start your test-drive NOW, so I can begin paving your path to wealth.


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Chelsea are ready to make moves for Everton striker Romelu Lukaku and Valencia right-back Joao Cancelo in the summer transfer window, according to reports.
Yahoo Sport claims that Antonio Conte has requested that Chelsea's hierarchy bolster the squad with new signings at the end of the season.
Conte asked Chelsea's board to sign Lukaku last year, explored the possibility of a potential deal last month and is ready to launch a new effort this summer.
Lukaku, who is valued at £70 million by Everton, has scored 16 goals in 23 appearances this season and is viewed by the Chelsea manager as a ready-made replacement for Diego Costa.
Chelsea are also ready to revive their interest in Cancelo after failing in their move for the Portugal international last summer.
The 22-year-old defender, who is wanted by Barcelona, is valued by Valencia at €30m (£25.6m).
Chelsea already have an advantage in the race for Cancelo as Barcelona will not be able to compete with the Premier League leaders unless they sell players first.


text:
Welfare Women, Violent Men
By Jody Raphael. Jody Raphael works with welfare recipients reentering the work force at the Taylor Institute in Chicago.
AS members of the House hobnob in their home districts this week, having cast their votes on welfare reform, we can expect much celebratory talk about how the United States is on the road to ending welfare as we know it.
The trouble is, unless the Senate votes otherwise this spring, many women who will be dropped from the welfare rolls can expect to encounter a formidable obstacle on the road to the world of work: Many of the men who move in and out of the lives of women who receive welfare checks to support themselves and their children do not want their partners to become employed and independent.
In fact, many women who rely on welfare benefits to feed, clothe, and house themselves and their children report that the men who are unable to support them or their children sabotage their efforts to move from welfare to work. Indeed, these men frequently resort to violence to prevent women from completing employment-training programs or from entering the work force.
A recent survey of 12 work programs serving welfare mothers across the US revealed that over half of all participants are being abused at home. The Women's Employment Network in Kansas City, Mo., reports that 8 in 10 of its clients who are trying to go from welfare to work suffer from domestic violence.
Domestic violence is also a prime reason why women get on welfare in the first place. Preliminary research at Northwestern University in Evanston, Ill., on a sample of Chicago welfare recipients found that nearly half mentioned abusive relationships as a factor in their need for welfare. Officials at some battered-women's shelters report from 60 percent to 95 percent of the women they help spend some time on welfare as they struggle to recover from years of abuse.
The stories are as consistent as they are heartbreaking. The night before an entrance exam or a job interview, men will show up to engage their partners in night-long quarrels, leaving the women sleep-deprived and unable to perform well. Or they will promise to provide critical child care or transportation, only to disappear or get high when needed. Others literally hide women's clothing and winter coats, tear up their completed applications or assignments, or deliberately batter them on the face, hoping that the women will be too injured or ashamed to expose their bruises and black eyes to the world.
Will abusers, because of a vote in Washington, suddenly see the error of their ways and graciously permit women to work? Or will welfare reform make young teens without skills or prospects become more likely to fall prey to crime and drugs or to older men who promise to take care of them? Or, as anecdotal evidence already suggests, will fears that working women will either meet new men or refuse to turn over hard-earned paychecks cause domestic violence to escalate?
It is clear that proposed changes in federal and state welfare policies have the potential of increasing the dependence of uneducated young women and their children on violent men and of increasing the incidence of domestic violence.
Perhaps hearing from constituents who've been glued to the O.J. Simpson trial for months now will prompt thoughtful senators in both parties to have the courage to slow down ''reform'' to examine this question. Otherwise, many young women who believed the guys who promised them the sun, moon, and stars -- but who suffered as these men battered their dreams and bodies instead -- will find themselves with nowhere to turn but 911. And we all know how much that helped Nicole Brown Simpson.
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3 hours drive south from Bangkok's Suvarnabhumi airport you can find Hua Hin, Thailand's oldest beach resort town and a favourite of the royal family. A beach side town built for holiday makers. It's higher end resorts attract, fine dining restaurants and host of activities and attractions make it very popular amongst families and mature westerners. When sailing in Hua Hin, make sure to check out Koh Singtoh (lion island) for diving and fishing.