text:
Locations: Limerick / Phoenixville
VFKH Montessori School
campuses in Phoenixville and Limerick, PA
About VFKH
Meet Our Faculty and Staff
Accreditation / Affiliations
Primary (Preschool & Kindergarten)
Calendar for School Year
Home > About VFKH > Faculty and Staff
All of our Teachers/Guides are diploma holders of the Association Montessori International (AMI). AMI was founded by Dr. Maria Montessori in 1929 and is the recognized global standard for Montessori quality. VFKH teachers hold a Master of Education in the Montessori Method. The teachers at VFKH have been teaching the Montessori Method between 5 to 30 years and our classroom assistants have been with the school 3 to 20 years.
Susan Kelly
Phoenixville/Limerick Campus
Mrs. Susan Kelly was first introduced to Montessori through a survey of education course while receiving her bachelor's degree. Mrs. Kelly spent a summer applying the concepts in a free summer program she created and was amazed at how brilliantly the children responded! Thus, Mrs. Kelly headed to Washington D.C. for her post-graduate AMI studies in Montessori and became a Primary Guide. After meeting and marrying Mr. Edward Kelly, the two opened Valley Forge Kinder House and the rest is history! Now they have 5 children and 8 grandchildren. Mrs. Kelly loves tennis, biking, walking, reading, and family time.
Limerick Campus Office
Chief Administrator
Mr. Kelly founded Valley Forge Kinder House in 1977 with his wife, Susan Kelly. Originally from the area, Edward Kelly has lived in Bryn Mawr, Ardmore, Wayne, and Royersford. He came to learn about Montessori through his wife and together they opened the school and have been dedicated to educating their 5 children and many more children through the years. Mr. Kelly enjoys making "Dad jokes", biking, travel, and road trips. Just ask about his cross country road trips!
Bernadette Kelly
Phoenixville/ Limerick Campus
Assistant Administrator
Ms. Bernadette attended Valley Forge Kinder House from the age of one and continued through 4th grade in Montessori. Ms. Bernadette studied child development and business administration. She worked in China and Taiwan as an educator. Later, Ms. Bernadette was the child care professional development manager for southeastern Pennsylvania. After having her own children, Ms. Bernadette enrolled in the Montessori Assistants to Infancy training for the prenatal through age 3 time of development. Ms. Bernadette loves spending time with her three children, live music, traveling, and cooking (and eating!).
Maria Greenland
Phoenixville Campus
Elementary Moderator
Mrs. Greenland grew up traveling in South America with her parents. During her education she experienced many types of training methods, but not Montessori. Once Mrs. Greenland had her own children, she did not want them to have the same experience. Looking for alternatives, she found Montessori. All three of her children grew up at VFKH. Mrs. Greenland has a degree in biomedical engineering and headed her own company for many years. Now that Mrs. Greenland's children are grown, she has also provided Spanish class for the elementary students as well as many other supportive roles at VFKH. Mrs. Greenland enjoys painting, order and sewing.
Mrs. Megawati (Megan) Tjokro
Primary Lead Teacher
Mrs. Tjokro believes that each of us is created uniquely. Mrs. Tjokro searched for an educational system that has a child centered approach. She discovered the Montessori educational method during her bachelors studies in Early Childhood Education. She then obtained her AMI Primary training in Atlanta followed by a Masters in Education from Loyola University in Maryland. Mrs. Tjokro is originally from Jakarta, Indonesia. She has a teenage daughter. When Mrs. Tjokro was young she helped in her grandmother's restaurant. Now she still loves to cook yummy Asian food and washing dishes. Her famous dishes are shrimp fried rice and fried wonton/dumplings. Yes, cooking is her hobby.
Mrs. Susan Forshaw
Primary Assistant
Mrs. Forshaw developed an interest in Montessori education because of the "hands-on" learning, child-centered approach, as a contrast to traditional education. As a trained Occupational Therapist, Mrs. Forshaw brings this knowledge into the environment. She is originally from Australia and has lived in the U.K. and France. Mrs. Forshaw now lives in Phoenixville with her British husband and two teenage children. Her favorite activities are hiking, admiring beautiful gardens, drinking, good coffee, and cooking.
Mrs. Diane Phelen
Limerick Campus
Primary Guide
Ms. Phelen started as a volunteer at VFKH in 10th grade and became very interested in Montessori. She continued on to college to earn a degree in Early Childhood Education. She then attended Washington Montessori Institute and completed her AMI Montessori Primary training. Ms. Phelen started teaching at VFKH in 1988 and has been here ever since! Over 30 some years. Ms. Phelen loves nature walks, singing, sewing, gardening, and children are her love.
Mr. Brian Jagusak
Mr. Jagusak was first introduced to Montessori by a professor in his "Women in Psychology" course. He was inspired to pursue Montessori after observing how children learn while in Ghana. Mr. Jagusak then went on to Washington Montessori Institute and obtained his AMI Montessori Primary diploma through Loyola University. Mr. Jagusak has lived in Maryland, New Jersey, and Pennsylvania and has taught in the area. Mr. Jagusak is married with identical twin 6 year old boys. He has a passion for soccer, specifically Liverpool Football club, and watching live music.
Mrs. Lindsay Olivier
Mrs. Olivier was first introduced to Montessori through a position in a Montessori school in New Mexico. She fell in love with Montessori. She then taught in South Korea and met her husband. After taking a year to travel, Mrs. O had the opportunity to work at a Montessori school in South Africa. Now Mrs. O has returned to the area after living abroad for 10 years. Mrs. O's 3 year old daughter is in Ms. Phelen's class and she is happy to be back living in Phoenixville!
What Makes VFKH a Special Experience?
Sign up to learn more about the VFKH difference and get our tuition information.
Privacy Policy. We do not sell or share your information with anyone.
Valley Forge Kinder House (VFKH) Montessori School has private preschool and elementary programs for children in the Royersford, Limerick, Collegeville, Audubon, and Phoenixville communities.
For a brighter beginning, schedule a tour
188 West Ridge Pike
(First United Methodist Church)
VFKH Parents
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text:
Rosana Silveira Reis
Nota biografica
Rosana SILVEIRA REIS has 30 years of experience in HRM, 15 of them she had been a Manager in large companies. Since 2000 she has been teaching HRM, IHRM and Organization Behavior in graduation and MBA courses. Currently, she is Associate Professor at ISG - Paris, France. She is also regular visiting professor at Fundação Dom Cabral – FDC, Brazil; Invited professor in MBA programs at IMPS Business School in Brno (Czech Republic) and at University of Bologna (Italy). In 2000 she received her scientific master in Business Administration from the Federal University of Santa Catarina (Brazil) and in 2010, her Ph.D. in Management from the University of Bologna (Italy). Her research focuses on Creativity and Innovation, Leadership, International HRM, Cross-Cultural Management and Global Teams.
rosana.reis@unibo.it
Piazza Scaravilli 2, Bologna - Vai alla mappa

redpajama_set_name: RedPajamaCommonCrawl


This state of the art ChubbWatch commercial security system is a cost effective security solution for your business. It is ideal for small businesses and will help protect your employees and assets. Connecting to Chubb BusinessWatch Monitoring will ensure your property is protected 24 hours a day, 7 days a week.


When you exit, or quit, an application, the memory it was using is returned to the Windows pot for use by other programs.
Click the program window's Close box, or double-click its Control-menu icon (at the upper-left corner of the window).
Right-click the program's taskbar button and choose Close from the shortcut menu.
If you haven't yet saved the changes you've made to your document, the program offers the chance to do so before it shuts down all the way. Finally, after this step, program's windows, menus, and toolbars disappear, and you fall "down a layer" into the window that was behind it.


text:
Q: Eclipse/Pydev debug error - [Invalid Frame] When I try to use the Eclipse/Pydev interactive console in debug mode, I am getting the following error:
[Invalid Frame]: Please select frame to connect the console.

This seems like something that could easily be corrected, but I don't have much experience with this. Searching SO and google did not turn up anything helpful.

A: As the message says, for the interactive console in debug mode, you need to have a frame selected -- this is the stack frame on the debug view (so, open the debug view and select the frame on which the commands you execute should be evaluated).

A: In my case the execution hadn't reached the breakpoint yet. When that happens you'll get something like:
Backend MacOSX is interactive backend. Turning interactive mode on.

redpajama_set_name: RedPajamaStackExchange


'It has been a long time coming, but I'm glad that the record has been finally corrected by Minister Shatter about how we reported our concerns about the unlawful termination of tens of thousands of lawfully issued fixed charge penalty notices. Approximately 10,000 of these lawfully issued notices were unlawfully terminated on a yearly basis by senior Garda officers. These practices have now ceased directly as a result of our complaints.
I still encourage any prospective Garda whistleblowers reporting malpractice, wrongdoing and corruption within the force to report their concerns to a member of the Oireachtas and seek advice from Transparency International Ireland.
John Devitt, TI Ireland's Chief Executive, said: 'I'm relieved for John Wilson and Maurice McCabe that the Minister has finally apologised. It's important to remember however that Sgt McCabe is still unable to do his job properly because he's not authorised to use the PULSE database without permission from a senior officer each time he needs to use it. This doesn't just prevent him from doing his work, it also sends the message to other Gardaí that Sgt McCabe is not to be trusted. The denial of access is a form of penalisation and Sgt McCabe's right to use PULSE needs to be restored without delay'.
TI Ireland has repeated its call on Data Protection Commissioner Billy Hawkes to clarify criticism of the Garda whistleblowers during an interview he gave to RTE News on 21 March. TI Ireland believes his interview gave the inaccurate impression that the whistleblowers were in breach of the Data Protection Act and that they had accessed PULSE unlawfully. His office has declined to issue a statement making it clear that at no time did either whistleblower share personal data with members of the public and that they did not access PULSE to download further evidence after Assistant Commissioner O'Mahoney's investigation was launched.
John Wilson and Sgt McCabe wish to advise that they are unavailable for interview.


Emory's Center for Health and Aging is addressing health care issues affecting the rapidly growing senior population in the United States through research, clinical care, community outreach and education.
One of the greatest challenges now facing the health care system in the United States is the rapid growth of the numbers of aging adults. It will have an unprecedented impact on the delivery of medical care, including supply of and demand for health care workers.
It is expected that the supply of health care providers may decrease at a time huge numbers of workers retire or reduce their working hours. And older adults consume a disproportionate share of American health care services, resulting in greater demand for services.
Led by Theodore (Ted) Johnson II, MD, MPH, the Center benefits from well-established and successful programs in clinical care, aging research and education at Emory's Wesley Woods Center, one of the nation's few campuses devoted to the health and well being of older adults.
Wesley Woods is one of the nation's most comprehensive centers for aging-related research, care and quality of life, serving more than 30,000 elderly and chronically ill patients each year through outpatient clinics, a hospital, skilled nursing care facility and residential retirement facility. In addition, Emory is affiliated with the Atlanta Veterans Affairs Medical Center, which has an extensive array of geriatric clinical, research and training programs.
The health care implications for seniors in Georgia and the U.S. are tremendous, according to Johnson. He says that the sheer numbers of older adults will place strains on our healthcare system and the family and professional caregivers who help them.
Johnson,who heads Emory's Division of Geriatric Medicine and Gerontology, notes that it's the cumulative effect of that surge – plus the fact that people are living far longer than ever before – that poses a looming crisis for the health care system.
For a glimpse of aging care and research at Emory: dementia research, Alzheimer's DETECT device, diagnosing memory loss, preventing heart failure, disease prevention through nutrition, aging and fitness, and more about health initiatives at Emory Healthcare.


text:
Q: Symmetric voltage oscillator How do I create an oscillating output (around 50 to 80 MHz) with both negative and positive voltage (parallel)?
I have got already a 48 MHz oscillator, but I don't mind about replacing it if it's required.

A: The simplest way to get such "inverted" clock signals is to get a "differential" oscillator that has both "CLK+" and "CLK-" output (clock and complementary clock), such as the
50 MHz Silicon Labs 530EB50M0000DG, the Cypress CY24293 (requires an external 25 MHz crystal to generate up to 100 MHz), etc.
If you already have a single-ended clock signal, you could generate clock and complementary clock output signals using a variety of IC with differential outputs, such as the ON Semiconductor MC100LVEL16, the Fairchild Semiconductor FIN1108MTD, etc.
Then, if necessary, you could use a DC blocking capacitor and a resistor (or diode) to level-shift (DC restoration) the signals where you want them, and perhaps a resistor divider to get the peak-to-peak levels you want.
It's possible to build a 50 MHz oscillator out of common parts based on a 74HC240 inverter, but it requires a bunch of tuning and tweaking.
At lower frequencies, I would generate the appropriate frequency, and then use an inverter to generated the complementary signal -- however, at 50 MHz, the inverter delays are a significant fraction of the complete cycle, so I'd prefer to use an IC with differential outputs so they're both delayed the same amount.
Out of curiosity, what sort of device are you feeding this kind of positive and negative complementary clock into?

A: Probably the best solution is a normal oscillator feeded into a differential amplifier, such as the one posted here
But you need a device with a good bandwith, at least 50-80 MV/s of slew rate, and also in that case you would obtain a triangular wave; so you need to fit that spec according to the steepness required for the edges.

A: Depending upon the required phase accuracy and output impedance, the simplest approach may be to run the signal through an inverter.  If you're using +5 logic levels, scale the positive-phase output to 0.5 volts by feeding it into a resistor divider with a 9:1 resistance ratio (e.g. 9K and 1K).  To get the negative-phase output, if a -0.5V supply is available, use a 9.5K resistor to the inverter output and a 1K resistor to -0.5V.  If -0.5 is not available but some more-negative supply is, use three resistors--one to the negative supply, one to ground, and one to the inverter output.


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Şenkaya  is a town and district of Erzurum Province in the Eastern Anatolia region of Turkey. The mayor is Görbil Özcan (AKP). The population is 2,803 (as of 2010).

Villages

 Akşar
 Aktaş
 Alıcık
 Aşağıbakraçlı
 Atyolu
 Aydoğdu, Şenkaya
 Balkaya, Şenkaya
 Bereketli, Şenkaya
 Beşpınarlar, Şenkaya
 Beykaynak, Şenkaya
 Çamlıalan, Şenkaya
 Çatalelma, Şenkaya
 Değirmenlidere, Şenkaya
 Deliktaş, Şenkaya
 Doğanköy, Şenkaya
 Dokuzelma, Şenkaya
 Dolunay, Şenkaya
 Dörtyol, Şenkaya
 Esence, Şenkaya
 Esenyurt, Şenkaya
 Evbakan, Şenkaya
 Gaziler, Şenkaya
 Gezenek, Şenkaya
 Göllet, Şenkaya
 Göreşken, Şenkaya
 Gözalan, Şenkaya
 Gözebaşı, Şenkaya
 Gülveren, Şenkaya
 Hoşköy, Şenkaya
 İçmesu, Şenkaya
 İğdeli, Şenkaya
 İkizpınar, Şenkaya
 İnceçay, Şenkaya
 Kayalısu, Şenkaya
 Kaynak, Şenkaya
 Kireçli, Şenkaya
 Köroğlu, Şenkaya
 Köşkköy, Şenkaya
 Kürkçü, Şenkaya
 Nişantaşı, Şenkaya
 Ormanlı, Şenkaya
 Oyuktaş, Şenkaya
 Özyurt, Şenkaya
 Penek, Şenkaya
 Sarıkayalar, Şenkaya
 Sarıyar, Şenkaya
 Sındıran, Şenkaya
 Söğütler, Şenkaya
 Susuz, Şenkaya
 Şenpınar, Şenkaya
 Tahtköy, Şenkaya
 Tazeköy, Şenkaya
 Teketaş, Şenkaya
 Timurkışla, Şenkaya
 Turnalı, Şenkaya
 Tütenocak, Şenkaya
 Uğurlu, Şenkaya
 Yanıkkaval, Şenkaya
 Yaymeşe, Şenkaya
 Yazılı, Şenkaya
 Yelkıran, Şenkaya
 Yeşildemet, Şenkaya
 Yeşilkaya, Şenkaya
 Yoğurtçular, Şenkaya
 Yukarıbakraçlı, Şenkaya
 Yünören, Şenkaya
 Yürekli, Şenkaya
 Zümrütköy, Şenkaya

References

Populated places in Erzurum Province
Districts of Erzurum Province

Kurdish settlements in Turkey

redpajama_set_name: RedPajamaWikipedia


Kitchen! Kitchen!: Another tasting......at kitchen! kitchen!
chocolate chips. They are just as good without the frosting.
dessert...good rich flavor...not too sweet....really wonderful"!
Thank you Peggy, you have just been designated as one of my tasters!
figs & duck.....at kitchen! kitchen!


text:
Who Is LIG?
Medical Programs
Youth Network
Help LIG Global CTEN
How LIG Global Is Continuing To Help The Community of Dajabon During the COVID Pandemic
LIG Global joins director, Dr. Angela Arias Castro in her mission to provide the beds of Hospital Ramon Matias Mella de Dajabón with enough bed sheets to ensure the comfort and safety of recovering patients.
Join the LIG Global team as they assist Dr. Arias in her ambitious goal for the community of Dajabón. All you need is a minute, a browser, and a carrier service.
Nestled on the Dominican/Haitian border, Dajabón is famous for its vibrant market. Open to both Hatian and Dominican shop owners, this biweekly (every Monday and Friday) market is where the locals shop. This vibrant community is filled with thousands of hard-working and underserved families.
Despite limited access to resources, supplies, and specialized healthcare, the medical professionals of Dajabón continue to adapt and respond to the needs of their community.
In LIG's 11 years of partnership with Hospital Ramón Matías Mella, we have provided: countless hours of continuing medical education, upgraded medical equipment, and specialized care to patients across the area. No patient is ever turned away, regardless of income, nationality, or illness.
Unlike the United States, several countries and cities around the world, including Dajabón, require patients to provide their own bed sheets when they receive care. Oftentimes, patients in these underserved communities do not have the luxury of extra bed sheets. Leaving dozens and dozens of patients to recover bare rubber hospital beds.
Patient recovers from childbirth without a bed sheet. She protects her newborn with extra blankets.
While this has been an ever present need for Hospital Ramón Matías Mella, and thousands of hospitals around the world, this new push and initiative is the brainchild of newly appointed director, Dr. Angela Arias Castro. A long time supporter and partner of LIG Global and Waves of Health, Dr. Arias will be familiar to volunteers who have joined us on past LIG missions to Dajabón. We are proud to assist her in her goal of obtaining new bed sheets for every hospital bed.
In our continued discussions with our colleagues in Dajabón, we were moved to action by Dr. Arias' goal. Our founding principles of integrity, sharing, and service urges us to continue providing compassion and comfort to communities around the world despite the global pandemic. We feel it is our duty as citizens of the global community to make positive changes wherever and whenever possible.
In order to ensure that every bed in Hospital Ramón Matias Mella has at least two sets of sheets, we are seeking support in the form of monetary donations. We have set a minimum goal of $1,500 that will allow us to outfit each bed in the hospital in either a twin or twin XL sheet set. However, we seek to exceed our minimum goal by receiving enough donations to guarantee every bed has at least two sheets. Accomplishing this will allow patients to recover peacefully and comfortably. Especially during these difficult times.
Dr. Angela Arias Castro (R? L?) and colleague.
We encourage donations in the following amounts:
$25 Donation would outfit one hospital bed with a set of twin bed sheets.
$50 Donation would outfit two hospital beds with twin bed sheets.
$100 Donation would outfit an entire recovery room with bed sheets.
$250 Donation would outfit an entire unit of the hospital with bed sheets.
All donations will be used to purchase the necessary sheets and then promptly sent to Dr. Arias directly. We will be collecting donations from now through the end of November. This is an urgent need for the patients and staff at Hospital Ramón Matías Mella and any amount is greatly appreciated.
Donors can donate through our website, ad campaign, newsletter, or via check.
From Top Left: A make shift sheet covers a hospital bed. Doctors Sylvester, Sadural, and Keegan pose for a photo.
From Bottom Left: Patient recovers after childbirth. A doctor passes through a courtyard in Hospital Ramón Matías Mella.
We look forward to our continuing partnership with Hospital Ramón Matías Mella and Dr. Angela Arias Castro and other upcoming initiatives to help the people of Dajabón, Dominican Republic.
Through this initiative, we are able to provide essential help and supplies to our brothers and sisters in Dajabon, even during a global pandemic. While bed sheets may seem like a small drop in a large bucket, it's the small things we take for granted that mean so much to those in need.
Together with Dr. Arias, our goal is to ensure a comfortable, cozy bed for recovering patients - whether or not they can provide their own sheets.
While bare hospital beds may seem strange to Americans, it is a common occurance to the rest of the world. Patients do not always have access to extra bed sheets, leaving them to lay on uncovered hospital beds and rubber mattresses.
Preserving Cervical Health Across Borders: LIG Global's Mission to Empower Peruvian Healthcare Workers
LIG Global's CEO, Dr. Claudine Sylvester, Receives and Discusses the New COVID Vaccine
LIG Global Initial Response to COVID-19
NJ Doctors Fly to Puerto Rico After Hurricane Maria
Walking-For-Women-in-India-Sep-12-2015
Life is Great (LIG) Global Foundation brings medical knowledge, educational strategies, and forges strong partnerships within underserved communities around the world. Through volunteerism, LIG is dedicated to serving the global community through sharing, service, and integrity.
11 Eliot Court Teaneck New Jersey 24966
info@ligglobal.org


As the OCR Championship Season is upon us, eyes move to Lake Tahoe as the sports finest head west for the Spartan Race World Championships. So let's kick this season off in style with the gear and races that the leaders of the pack will be sporting. OCRAddict has partnered with Marena for a killer giveaway!!! Two prizes for our fellow #OCRAddict, a $300 gift card to Marena's top of class compression gear and a free Spartan Race credit.


Any of us more than twenty-five years old can probably remember where we were when we first heard of President Kennedy's assassination in 1963.
British novelist David Lodge, in the introduction to one of his books, tells where he was--in a theater watching the performance of a satirical revue he had helped write. In one sketch, a character demonstrated his nonchalance in an interview by holding a transistor radio to his ear. The actor playing the part always tuned in to a real broadcast. Suddenly came the announcement that President Kennedy had been shot. The actor quickly switched it off, but it was too late. Reality had interrupted stage comedy. For many believers, worship, prayer, and Scripture are a nonchalant charade. They don't expect anything significant to happen, but suddenly God's reality breaks through, and they're shocked.


text:
Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism
Andrew P. Hinck
The increasing availability of detailed structural information on many biological systems provides an avenue for manipulation of these structures, either for probing mechanism or for developing novel therapeutic agents for treating disease. This has been accompanied by the advent of several powerful new methods, such as the ability to incorporate non-natural amino acids or perform fragment screening, increasing the capacity to leverage this new structural information to aid in these pursuits. The abundance of structural information also provides new opportunities for protein engineering, which may become more and more relevant as treatment of diseases using gene therapy approaches become increasingly common. This is illustrated by example with the TGF-β family of proteins, for which there is ample structural information, yet no approved inhibitors for treating diseases, such as cancer and fibrosis that are promoted by excessive TGF-β signaling. The results presented demonstrate that through several relatively simple modifications, primarily involving the removal of an α-helix and replacement of it with a flexible loop, it is possible to alter TGF-βs from being potent signaling proteins into inhibitors of TGF-β signaling. The engineered TGF-βs have improved specificity relative to kinase inhibitors and a much smaller size compared to monoclonal antibodies, and thus may prove successful as either as an injected therapeutic or as a gene therapy-based therapeutic, where other classes of inhibitors have failed.
TGF-beta
Dive into the research topics of 'Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism'. Together they form a unique fingerprint.
Genetic Therapy Medicine & Life Sciences 100%
Phosphotransferase Inhibitor Chemical Compounds 90%
Protein Chemical Compounds 89%
Protein Engineering Medicine & Life Sciences 73%
Phosphotransferases Medicine & Life Sciences 41%
Modification Chemical Compounds 39%
Hinck, A. P. (2018). Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism. Bioorganic and Medicinal Chemistry, 5239-5246. https://doi.org/10.1016/j.bmc.2018.07.008
Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism. / Hinck, Andrew P.
In: Bioorganic and Medicinal Chemistry, 15.10.2018, p. 5239-5246.
Hinck, AP 2018, 'Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism', Bioorganic and Medicinal Chemistry, pp. 5239-5246. https://doi.org/10.1016/j.bmc.2018.07.008
Hinck AP. Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism. Bioorganic and Medicinal Chemistry. 2018 Oct 15;5239-5246. https://doi.org/10.1016/j.bmc.2018.07.008
Hinck, Andrew P. / Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism. In: Bioorganic and Medicinal Chemistry. 2018 ; pp. 5239-5246.
@article{0090ffc8a7654ad0abbfb31b3b671534,
title = "Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism",
abstract = "The increasing availability of detailed structural information on many biological systems provides an avenue for manipulation of these structures, either for probing mechanism or for developing novel therapeutic agents for treating disease. This has been accompanied by the advent of several powerful new methods, such as the ability to incorporate non-natural amino acids or perform fragment screening, increasing the capacity to leverage this new structural information to aid in these pursuits. The abundance of structural information also provides new opportunities for protein engineering, which may become more and more relevant as treatment of diseases using gene therapy approaches become increasingly common. This is illustrated by example with the TGF-β family of proteins, for which there is ample structural information, yet no approved inhibitors for treating diseases, such as cancer and fibrosis that are promoted by excessive TGF-β signaling. The results presented demonstrate that through several relatively simple modifications, primarily involving the removal of an α-helix and replacement of it with a flexible loop, it is possible to alter TGF-βs from being potent signaling proteins into inhibitors of TGF-β signaling. The engineered TGF-βs have improved specificity relative to kinase inhibitors and a much smaller size compared to monoclonal antibodies, and thus may prove successful as either as an injected therapeutic or as a gene therapy-based therapeutic, where other classes of inhibitors have failed.",
keywords = "Cell signaling, Inhibitor, Protein engineering, TGF-beta",
author = "Hinck, {Andrew P.}",
note = "Funding Information: APH is supported by NIH R01GM58670 , NIH CA172886 , DOD W81XWH-17-1-0429 , and by the University of Pittsburgh Vascular Medicine Institute . Funding Information: APH is supported by NIH R01GM58670, NIH CA172886, DOD W81XWH-17-1-0429, and by the University of Pittsburgh Vascular Medicine Institute. Publisher Copyright: {\textcopyright} 2018 Elsevier Ltd",
T1 - Structure-guided engineering of TGF-βs for the development of novel inhibitors and probing mechanism
AU - Hinck, Andrew P.
N1 - Funding Information: APH is supported by NIH R01GM58670 , NIH CA172886 , DOD W81XWH-17-1-0429 , and by the University of Pittsburgh Vascular Medicine Institute . Funding Information: APH is supported by NIH R01GM58670, NIH CA172886, DOD W81XWH-17-1-0429, and by the University of Pittsburgh Vascular Medicine Institute. Publisher Copyright: © 2018 Elsevier Ltd
N2 - The increasing availability of detailed structural information on many biological systems provides an avenue for manipulation of these structures, either for probing mechanism or for developing novel therapeutic agents for treating disease. This has been accompanied by the advent of several powerful new methods, such as the ability to incorporate non-natural amino acids or perform fragment screening, increasing the capacity to leverage this new structural information to aid in these pursuits. The abundance of structural information also provides new opportunities for protein engineering, which may become more and more relevant as treatment of diseases using gene therapy approaches become increasingly common. This is illustrated by example with the TGF-β family of proteins, for which there is ample structural information, yet no approved inhibitors for treating diseases, such as cancer and fibrosis that are promoted by excessive TGF-β signaling. The results presented demonstrate that through several relatively simple modifications, primarily involving the removal of an α-helix and replacement of it with a flexible loop, it is possible to alter TGF-βs from being potent signaling proteins into inhibitors of TGF-β signaling. The engineered TGF-βs have improved specificity relative to kinase inhibitors and a much smaller size compared to monoclonal antibodies, and thus may prove successful as either as an injected therapeutic or as a gene therapy-based therapeutic, where other classes of inhibitors have failed.
AB - The increasing availability of detailed structural information on many biological systems provides an avenue for manipulation of these structures, either for probing mechanism or for developing novel therapeutic agents for treating disease. This has been accompanied by the advent of several powerful new methods, such as the ability to incorporate non-natural amino acids or perform fragment screening, increasing the capacity to leverage this new structural information to aid in these pursuits. The abundance of structural information also provides new opportunities for protein engineering, which may become more and more relevant as treatment of diseases using gene therapy approaches become increasingly common. This is illustrated by example with the TGF-β family of proteins, for which there is ample structural information, yet no approved inhibitors for treating diseases, such as cancer and fibrosis that are promoted by excessive TGF-β signaling. The results presented demonstrate that through several relatively simple modifications, primarily involving the removal of an α-helix and replacement of it with a flexible loop, it is possible to alter TGF-βs from being potent signaling proteins into inhibitors of TGF-β signaling. The engineered TGF-βs have improved specificity relative to kinase inhibitors and a much smaller size compared to monoclonal antibodies, and thus may prove successful as either as an injected therapeutic or as a gene therapy-based therapeutic, where other classes of inhibitors have failed.
KW - Cell signaling
KW - Inhibitor
KW - Protein engineering
KW - TGF-beta


text:
Red Zone es un videojuego desarrollado por Zyrinx y publicado por Time Warner Interactive en 1994 para la videoconsola Sega Mega Drive. El juego, aunque no es muy conocido, es notable por usar varias  técnicas gráficas rara vez vistas en el hardware de Mega Drive como rotaciones de gráficos y texturas de fondo, vectores 3D, zoom en tiempo real o full motion video.

La desarrolladora Zyrinx (hoy desaparecida) donó al dominio público una versión pre-lanzamiento de este juego (que en aquella fase del desarrollo tenía el título de HardWired).

Referencias

Enlaces externos

 Análisis del juego en Sega-16 (en inglés)

Videojuegos de 1994
Videojuegos de disparos
Videojuegos para Sega Mega Drive
Videojuegos exclusivos para Sega Mega Drive
Videojuegos desarrollados en Dinamarca
Videojuegos con música de Jesper Kyd


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Boilermaker jobs in Gauteng | Careerjet.co.
Boilermaker Jobs in Johannesburg - Pnet.co.
Search Boilermaker jobs in Johannesburg with company ratings & salaries. 15 open jobs for Boilermaker in Johannesburg.
4 510 Boilermaker jobs available in Johannesburg on neuvoo South Africa. Your job search starts here.
Boilermaker jobs in Johannesburg | Careerjet.co.
One of the leading FMCG companies is offering just that. A dynamic recognised manufacturing giant is currently looking to recruit a Mechanical Fitter to join their company. With its vast potential for growth the successful candidate will be responsible for the day to day maintenance of equipment plants to ensure smooth production.


From the talented vice of Tim Borski we have this perfect answer to going "Brown and Down"
Redfishers Rootbeer: This is yet another original fly pattern from Keys Artist and Master Fly Tier Tim Borski. First of all it is the dark brown color that makes this pattern work so well in dark water low light conditions. It was a group of Redfish Guides from South Carolina who coined the praise for fly selection to go "Brown and down" when redfish become selective feeders.


Within an hour after the execution of Michael Roburoff the Ithuriel was winging her way back to Aeria, and at least two of her company were anticipating their return to the valley with feelings very different to those with which they had contemplated their departure.
When the last farewells and congratulations had been spoken, and the air-ship rose from the earth, Tremayne returned to the house to commence forthwith the great task which now developed upon him; for in addition to being Chief of the Central Executive, he now assumed the direct command of the American Section, which, after long consideration, had been selected as the nucleus of the Federation of the English-speaking peoples of the world.
For a fortnight he worked almost night and day, attending to every detail with the utmost care, and bringing into play all those rare powers of mind which in the first instance had led Natas to select him as the visible head of the Executive. In this way the chief consequence of the love-madness of Roburoff had been to place at the head of affairs in America the one man of all others most fitted by descent and ability to carry out such a work, and to this fact its complete success must in a great measure be attributed.
So perfectly were his plans laid and executed, that right up to the moment when the signal was given and the plans became actions, American society went about its daily business without the remotest suspicion that it was living on the slope of a slumbering volcano whose fires were so soon to burst forth and finally consume the social fabric which, despite its splendid exterior, was inwardly as rotten as were the social fabrics of Rome and Byzantium on the eve of their fall.
On the 1st of October the cables brought the news of the fall of the Quadrilateral; the storming of Hamburg, and the retreat of the British forces on Antwerp. Four days later came the tidings of a great battle under the walls of Antwerp, in which the British and German forces, outnumbered ten to one by the innumerable hosts of the League, had suffered a decisive defeat, which rendered it imperative for them to fail back upon the Allied fleets in the Scheldt, and to leave the Netherlands to the mercy of the Tsar and his allies, who were thus left undisputed masters of the continent of Europe.
This last and crowning victory had been achieved by exactly the same means which had accomplished all the other triumphs of the campaign, and therefore there will be no need to enter into any detailed description of it. Indeed, the fall of the Quadrilateral and the defeat of the last army of the Alliance round Antwerp would have been accomplished much more easily and speedily than it had been but for the fact that the weather, which had been fine up to the end of July, had suddenly broken, and a succession of violent storms and gales from the north and north-west had made it impossible for the war-balloons to be brought into action with any degree of effectiveness.


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Q: Case Sensitive FileManager.default.fileExists(atPath:) When I on my Mac run
FileManager.default.fileExists(atPath: path)

the resulting check is case-insensitive. So filePath will return the same as FiLePaTh. I need it to do a case-sensitive check however. Is there any way of achieving this?
I am running this on macOS 12.3 on an APFS formatted volume.


Can Strategic Nuclear Competition and Cooperation Coexist?
A Sino-Indo civil nuclear deal would have to clear substantial domestic and regional hurdles.
The agreement between the two leaders to initiate civil nuclear energy bilateral talks is significant, given the competitive nuclear dynamic that exists between China and India. Notwithstanding the significance of this initiative for commercial and energy security objectives as mentioned in the above statements, a host of technical and, more importantly, strategic considerations that have not yet been fully appreciated are likely to drive or hinder such cooperation.
Both China and India are advanced nuclear energy countries and are expanding their respective civil nuclear energy sectors. The two neighbors have well-established nuclear fuel cycles and reactor designs which are on par with international safety standards. However, they vary considerably on the scale and size of their respective civil nuclear energy programs. The Chinese civilian program is growing at a far faster pace with 22 reactors under operation and 27 reactors under construction, while India has 21 reactors under operation and six reactors under construction.
Besides rapidly expanding its civil nuclear power generation capacity, China is aggressively pushing for nuclear reactor exports to friendly countries. Chinese nuclear giants such as China National Nuclear Corporation (CNNC) and China Guangdong Nuclear Power Holding Co., Ltd (CGNPC) are exploring new markets to export their reactor technology. India, which has ambitious plans for the expansion of its civil nuclear energy sector, naturally constitutes a lucrative market that the Chinese nuclear giants would like to access.
China's willingness to engage in nuclear commerce with India underlines a noticeable shift in Beijing's attitude. The only instance in which China officially engaged in nuclear cooperation with India was in 1995, when China supplied 30 tons of Low Enriched Uranium (LEU) for the two safeguarded Tarapur reactors. However, China was quick to terminate the LEU supply agreement after India's Pokhran nuclear tests in May 1998.
One of the possible explanations for China's support of India's waiver by the Nuclear Suppliers Group (NSG) in 2008 could well be its aspiration to engage in nuclear commerce with India just as other members of the NSG do. Whether or not that is the case, the fact is that India's civil nuclear energy market offers billions of dollars in investment opportunities, and Chinese firms are keenly exploring the potential for meaningful cooperation.
For Beijing, nuclear commerce with India could also be geo-strategically significant in terms of gaining the diplomatic upper hand over Japan. Despite New Delhi's persistent diplomatic overtures, Tokyo has been reluctant to enter into a bilateral nuclear cooperation accord. While Japan has invested in large-scale infrastructure development projects in India, China's decision to do the same while also investing in strategic sectors like nuclear and space could buy it considerable influence relative to Japan in Delhi's strategic calculus. For Beijing, the proposed nuclear cooperation with India could be significant from an economic and strategic standpoint.
Notwithstanding Beijing's keen interest in nuclear cooperation with India, an affirmation by the Indian premier to initiate nuclear energy cooperation talks with Beijing is puzzling for several reasons. As part of its civil nuclear energy expansion strategy, India has signed several bilateral nuclear cooperation agreements in the aftermath of the "Indo-US nuclear deal" – Delhi is currently negotiating techno-commercial agreements for constructing nuclear power plants with Russia, France and the U.S. To this extent, India could positively consider any Chinese proposed sale of nuclear reactors, after certifying that the reactor designs offered by China meet the desired Indian regulatory and safety requirements.
At the commercial level, India's decision to buy Chinese nuclear reactors would be determined by factors such as cost, construction time, possibilities for technology transfer, and the participation of the Indian industry in reactor construction. The cost and terms of technology transfer could well be the key determinants influencing India's decision to accept the Chinese reactors. China, which has earned a global reputation for low-cost manufacturing, would be expected to offer reactors at a competitive price compared to Indian reactor manufacturing costs.
Apart from the aforementioned commercial considerations, it is not clear strategically how engaging in nuclear cooperation with Beijing would impinge on New Delhi's longstanding protestations over Sino-Pakistani nuclear and missile cooperation. New Delhi has been deeply wary of Beijing's atomic bonhomie with Islamabad. Will nuclear cooperation with Beijing compel New Delhi to drop its long-standing objections to Sino-Pakistani nuclear cooperation? Will India be able to oppose any future China's nuclear cooperation with Pakistan, or for that matter, Beijing's support of any possible NSG waiver for Pakistan?
Although the discussions on civil nuclear cooperation are at a very preliminary stage, the BJP government in New Delhi will have to tackle such questions before making any concrete move on Beijing's proposal. Engaging in nuclear cooperation with China may tie Indian hands in many ways that would not only affect South Asian regional dynamics, but also the larger Asian nuclear order by way of enhancing the Chinese sphere of influence in the nuclear domain. It nevertheless remains to be seen how India will manage nuclear cooperation with Beijing, and whether an attractive commercial deal for Chinese nuclear reactors would override New Delhi's other considerations.
Kapil Patil is a Research Assistant at the Indian Pugwash Society, New Delhi. The views expressed are his alone.


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Micah Allen
Digital Content Producer
Micah is a Digital Content Producer for CBS7 News in West Texas
Father charged with murder in 11-month-old child's death, deputies say
By Micah Allen and Emily Van de Riet
A father in Texas has been charged with capital murder for the death of his 11-month-old child, officials said.
Parents charged with murder for death of 8-year-old boy, court documents say
Updated: Nov. 21, 2022 at 4:44 PM EST
Parents in Texas have been charged with capital murder after their 8-year-old son died at a hospital earlier this month from "suspicious injuries."
Lawyers return to court in Sunset Lounge lawsuit
Nikkitia Bryant viewing held at St. Mark Missionary Baptist Church
Officers say 'dismantling' of Postal Police force allows for more mail theft
Head of Palm Beach Co. Black Caucus thinks relations better here than in Memphis
Restaurants remain understaffed even as demand recovers after pandemic
Ex-police officers accused of beating homeless man
South Florida lawmakers push to expand state's 'red flag' law
Electrical fire prompts evacuation of Palm Springs Community Middle School


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Ahmad ibn Abd al-Aziz Al Su'ud (ur. 1942) – saudyjski książę.

Urodził się w Rijadzie. Jest jednym z synów króla Abd al-Aziza ibn Su'uda oraz jego ósmej małżonki, Hasy as-Sudajri. Kształcił się w Szkole Książęcej w Rijadzie oraz instytucie al-Andżal, następnie zaś studiował na University of Southern California i University of Redlands (w 1999 otrzymał doktorat honorowy tej drugiej uczelni).  Od 1971 roku pełnił funkcję zastępcy gubernatora Mekki. W 1975 roku objął stanowisko wiceministra spraw wewnętrznych. Zajmował je do 2012 roku. Po śmierci szefa MSW, księcia Najifa, stanął na czele resortu spraw wewnętrznych. Z funkcji zrezygnował 5 listopada 2012.

Przypisy

Doktorzy honoris causa uczelni w Stanach Zjednoczonych
Saudowie
Saudyjscy ministrowie
Urodzeni w 1942
Ludzie urodzeni w Rijadzie


I'm all about Essential Oils. I grew up with my mom using essential oils, specifically Tea Tree oil, to help cuts and whatnot heal. I actually use my Lavender and Peppermint oils as perfumes! Essential Oils are basically a concentrated oil that comes from different plants…there's a lot more to it than that, so if you want, check out how Young Living does it!
So what do you do with Essential Oils? How do you use them? Well, the fun thing is, you can basically use Essential Oils on/with everything. Cooking, wellness, cleaning, and even to get rid of pimples! There are a ton of ways to put them to good use…but I'm going to share with you some of my favorite Essential Oils that I always have and what I do with them!
Lavender has always been associated with a calming effect, and it truly does work! If I know I have a long or stressful day ahead of me, I'll put my little Lavender oil in my purse and simply smell it when I'm starting to feel overwhelmed. It helps me come back to my center and focus. You can even infuse salts with the oil for a calming bath or blend together some lavender and water in a spray bottle and spray your bed before you go to sleep to ensure a restful night! Lavender is also wonderful for getting rid of headaches!
Peppermint is known as the "cooling" oil. Which makes sense! When you have peppermint gum, you get a cool rush! Peppermint oil is a great alternative to Vick's Vapor Rub or those little Vapo Inhaler's. When you think about it, those things are essentially just peppermint in different forms! So I use the actual concentrated, natural oil instead of buying the other stuff. You can mix coconut oil and Peppermint oil (maybe even add in some Eucalyptus oil) to make your own homemade, natural vapor rub! Peppermint is also great for fevers and digestive issues!
Eucalyptus is one of those oils that can basically do everything! It's awesome for jet lag…you can make a little spray for after your flight to spray on your face and wake you up! It's also good for coughs, congestion, a natural cleaner for around the house, and even to care for your wounds / cuts!
Tea Tree is one of the best things to keep in your house. I grew up with my mom using it for all sorts of things, but mostly cuts and insect bites! So if you're going camping, bring your Tea Tree oil with you! It's also amazing for acne and getting rid of pesky pimples! Bye bye unwanted pimples!
There are many different Essential Oils to check out but these four are my favorite. Don't get me wrong, I also have: Orange, Lemon, Frankincense, Lemongrass, Clary Sage, and Oregano! I love using these oils in my daily life. They're a wonderful alternative for people who like to use natural remedies, rather than all those crazy packages and tubes at the store that are filled with poisons. Yeah, I'm a hippie. Proud of it.
Leave a comment below and tell me: Have you used Essential Oils before and which one is your favorite?! And don't forget to subscribe!
PS- Little hacking tip: Essential Oils can be expensive…but I always get mine at places like Nordstrom Rack, or TJ Maxx!! You can get them there of much cheaper and usually in little packs of 3!


Will competed at URCC Dutdutan 16 last night and brought home another 1st round submission victory against Morteza Mombashi by RNC. Congrats to Will and check out the video below. We are all looking forward to seeing him competing in the cage again soon!!
Mike travels to the Philippines and brings home the UGB MMA light heavyweight belt!
Combat 360X fighter and coach Mike "Rambo" Saint Claire fought former URCC Cruiser Weight title contender Frank Navarro at UGB 15:Foreign Invasion 2. Mike quickly took the fight to the ground at the beginning of the first round and secured an arm triangle victory in 50 seconds to become the UGB MMA Light Heavyweight Champion.
We look forward to welcoming Mike back to Combat 360X Muay Thai, MMA and fitness camp in Khao Lak and adding another championship belt to our collection!
Mike wants to thank everyone at Combat 360X for the support, Fightlab for making great equipment, Nanox Thailand for the world class supplements, Vicious Circle and Mayhem Musclewear for the custom gear!! Also thank to UGB MMA and World Series of fighting global championship for putting on a great event for all involved.
Combat 360X Muay Thai, MMA and fitness camp staff and guests were out in force yesterday to celebrate the Thai New Year in Khao Lak. Songkran festival is one of the most enjoyable events of the year. Stretching out over the 13th,14th and 15th it involves everyone in the country getting involved in what is largely regarded as the biggest water fight on earth!!
Combat 360X fighters Ahmed "Wolverine" Mujtaba and Haider 'The Giant" Farman both won their Muay Thai fights last night at Khao Lak boxing stadium by 2nd round KO.
Ahmed in his first Muay Thai fight battled with a strong Thai opponent and finished him with a big knee to the body.
Haider overwhelmed his opponent with with punches before landing the KO shot in the 2nd round.
It was a great pleasure to watch these two warriors in action and we look forward to watching them move through the Muay Thai ranks here.
All of the team at Combat 360X Muay Thai, MMA and Fitness camp in Khao Lak, Thailand want to send our best wishes to our coach and fight team member Will Chope as he prepares to fight on the 20th of December at Pancrase 274 in Japan!!
Will is a very hard worker, an awesome MMA fighter and we are sure he will bring home the win!!


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Introducing Katie Billings and Sam Patzkowsky - new grad fellows in EPS
By Jan Foster
Katie and Sam join the Department of Earth and Planetary Sciences as two of our newest McDonnell Center Graduate Fellows.
Katie joins us from Bryn Mawr College and will be working with Professor Phil Skemer. We are pleased to announce that Katie is the inaugural recipient of the Larry A. Haskin Graduate Fellowship. Katie shared, "I am excited to tackle interesting questions about the origins of plate tectonics and expand my skills as a scientist while working in the ESPM rock deformation lab. I am grateful for the freedom the Larry A. Haskin Graduate Fellowship will provide as I pursue my graduate studies."
Sam received his undergraduate degree from Franklin & Marshall College and he plans to work with Professor Rita Parai. When asked about his decision to do his graduate studies in St. Louis he said, "I chose WashU because of the research opportunities and the supportive community present within the department. I believe that the science being conducted at WashU is truly the most exciting; I, simply, cannot wait to dive headfirst into it. WashU's research experience is unmatched from any of the other schools I looked at and I know that this school and my graduate program will set me up properly for the remainder of my career."
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NASA selects astrophysics mission to detect ultrahigh-energy neutrinos
Jim Mertens recently joined the Department of Physics
Leading missions and making policy
Gravitational waves probe exotic matter inside neutron stars


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Joe Biden's 23-Minute Challenge
Clarke, Opinion, This Week in the Narrative,
This Week in the Narrative 126
by Nigel Clarke April 17, 2019, 11:55 am
As Joe Biden moves through the early stages of another presidential run, he appears ready to stumble into the same quicksand as Hillary Clinton, and it is not clear if he recognizes it.
Last week, no less than eight women came out and accused Biden of inappropriately touching them in an unwanted and unauthorized manner – along with many, many videos and pictures which seem to show this happening to a variety of women and, more disturbingly, children.
In response, Biden read a statement in which he said the following:
"I shake hands, I hug people, I grab men and women by the shoulders and say, 'You can do this.' Whether they are women, men, young, old, it's the way I've always been. It's the way I show I care about them, that I listen. Social norms have begun to change, they've shifted. And the boundaries of protecting personal space have been reset. And I get it. I get it. I hear what they're saying, I understand it. And I'll be much more mindful. That's my responsibility and I'll meet it."
He released the statement on Twitter, an effort to interact with the modern age, but still missed the point.
In 1994, the statement likely would have been the end of it, with some still vaguely skeptical, others perhaps still angry, but many thinking, 'Ah, give the old guy a break, he's just being friendly.'
The problem is, in this new era, millions have people have seen the videos and pictures of Biden's actions with their own eyes by now, and what they have seen is that 'hugging,' 'shaking hands,' even 'grabbing by the shoulders,' may not be the best description of what is happening.
A better description might include words like nuzzling, kissing, rubbing, sniffing, groping, as the recipients flinch, move away, scan the room with desperate eyes silently pleading for someone to intervene.
I understand that touching people without their consent must be a strong aphrodisiac for Joe Biden, doubly so when mixed with the aphrodisiac of power which comes from doing it in front of their spouses, parents, in front of television cameras, with no one willing or able to put a stop to it. But surely Biden cannot be so ignorant as to believe he will simply call his actions something they're not, contrary to what millions have seen with their own eyes, and be done with it.
Or maybe he can be that ignorant …
Two days after he released his statement, Biden gave a speech to the International Brotherhood of Electrical Workers Construction Conference. As he took to the stage, he hugged the man who had introduced him and, with a smirk, told the crowd "I just want you to know. I had permission to hug [him]," drawing uproarious laughter.
It was as if he truly didn't know that near every person in the room was holding a camera in their hand, that within minutes the quote would be making its rounds on social media as #CreepyUncleJoe became a trending topic, that within hours many pieces would be written on the audacity of a Democratic presidential contender mocking the alleged victims of his assaults mere days after their claims were brought forward.
It seems possible that Joe Biden was actually unaware this was going to happen, and that he might honestly be ignorant of the fact that it is going to happen each and every time he tries a ridiculous manipulation from here on out.
If the fate of his good friends the Clintons is not enough to deter Biden from a hopeless bid for the White House — their legacies exposed by the scrutiny of a new age, their so-called accomplishments disproven and invalidated, their family moved from among political royalty to villains of our time — then perhaps we need to go further.
Thus, I would like personally, and in earnest, to do Joe Biden a favor, though he may not deserve it. I would like to present a real-time example of how the electorate is going to be interacting with his campaign, how they will be interacting with the main narratives he'll be using.
Hopefully, this will cure his ignorance about what he's up against and encourage him to retire to a yacht in the Mediterranean, rather than flamethrower his life's work.
Ready Joe? Alright! Remember, this is in real time.
(The amount of time spent searching for and reading or watching each point is in brackets)
Narrative #1: 'Joe Biden will win with workers in the Midwestern swing states that Trump won.'
The manifestation of Biden's nickname, "Scranton Joe." The implication being that Scranton, Pennsylvania is a hard-working blue-collar town, and thus Joe Biden, who is from there, is a blue-collar representative of the every (wo)man.
Search: 'Joe Biden'
(30 seconds)
On Biden's Wikipedia page, the first and easiest example to examine, we see that while Joe was born in Scranton, he moved to Delaware as a child. There, he attended private school before heading off to college then law school in between spring break trips to the Bahamas. In other words, "Scranton Joe" has nothing to do with Scranton. He didn't go to school there, didn't play sports there, didn't work there; his collar shows not even a tinge of blue. In less than a minute we have learned that even Joe Biden's fun nickname is a manipulation, a lie. This would not have been possible for the first 30-plus years of Biden's political career.
Search: 'Joe Biden Workers Rights'
A detailed article on Biden's neoliberal policy history which compares his 'Scranton Joe' character to a satirical character in The Onion by saying "neither is actually real."
Another article detailing Biden's support for NAFTA — which cost the country something like 1 million jobs — and, more recently, his support for "NAFTA on Steroids," the TPP. And finally, an article from 2015 asking, with an apparently negative answer, "Can Joe Biden count on union support?"
It seems like with a few minutes of research, blue-collar Midwesterners living in the shadows of burnt-out factories might not be as 'for' Joe Biden as he thinks they are.
#2- 'Joe Biden is tough! He will hammer Trump for his racism;'
Search: "Joe Biden African-American Community History"
The first result, an article titled, "Joe Biden's Problematic Record On Racial Justice Explained." Then, an article detailing Biden's support for school segregation in the 1970s, followed by one titled, "Joe Biden, Mass Incarceration Zealot," which covers his authorship of the 1994 Crime Bill which decimated black communities.
It appears the question of who is racist and who is not isn't as clear-cut as originally assumed.
#3 – He'll hammer Trump for his sexism;
Search: 'Joe Biden Women's Rights'
(3 Minutes) –
A recent article remembering Biden's treatment of Anita Hill in 1991. As the article explains:
"Biden was the Senate Judiciary chair when Hill brought allegations that then-Supreme Court nominee Clarence Thomas sexually harassed her at two different jobs. At the time, he was in charge of overseeing how Hill's testimony was presented to senators before they decided to confirm Thomas to the Supreme Court.
… [the hearing] was confrontational — and in 1991, the all-white, all-male committee openly questioned her credibility. Biden has been criticized not just for the hearing's tenor, but also for its structure and his refusal to bring forth additional witnesses who could have substantiated Hill's allegations.
Add about two minutes and thirty seconds watching a video of Biden groping at women and girls — the longest possible stretch a normal human being could stomach watching at one time — and it appears he might not be much better than the man who says "grab them by the pussy."
#4 – He'll hammer Trump for his anti-immigrant rhetoric.
Search: 'Joe Biden Immigration'
An article titled "Joe Biden, Anti-Immigrant Enabler."
Uh oh …
If the strategy of Democrats in 2020 is to attack Trump from the moral high ground, it seems that in short order millions of people will be finding out that Joe Biden doesn't have a leg to stand on.
We've been at it now for 23 minutes. That's how long it has taken for the majority of Joe Biden's narrative to go up in flames.
Do your thing Joe, but before you do, this is something you should probably recognize is a thing.
Bonus narrative: 'Joe Biden is the candidate with the best chance to beat Trump.'
This is the main Biden narrative I didn't yet mention. Truth is, at the moment both Joe Biden and Bernie Sanders are polling beyond the margin of error ahead of Trump, while all other Democratic candidates lag behind.
But what happens when people with phones in their hands and Twitter on their minds start doing their own version of this 23-minute challenge for Joe Biden? Will he be asking, confused and befuddled about why he is not 50 points ahead? And perhaps, if we are talking frontrunners, we should do this type of 23-minute challenge for Bernie.
Previous article Ilhan Omar Has Exposed the Racism Permeating Congress
Next article Republicans Want To Rip Apart the Democratic Party – Don't Let Them
Written by Nigel Clarke
Writer and notorious vagabond. From the frozen north. Follow Nigel on Twitter @Nig_Clarke.
Nigel Clarke is a Writer for Progressive Army.
Israel and South Africa: The Racial Travel Bans of Apartheid
by Jon Blum
Donald Trump, In the News, Politics,
Trump Angry With Less Than Perfect Fox News Coverage
by Team Progressive Army
Donald Trump, Politics, Race,
New Report: Donald Trump's Name and Rhetoric Used in 36 Cases of Violence, Threats, and Assault
Justice, Opinion,
Biden Needs to Own Up to the '94 Crime Bill
by Tracey Corder
Bernie's Socialism
by Nigel Clarke
Politics, Salamone,
2020 Democratic Primary Debates Drinking Game
by Michael Salamone
Ilhan Omar Has Exposed the Racism Permeating Congress


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Sean Arata
Primarily known in Fort Wayne for hisrole in the rock band Downstait, Sean Arata has spent the past few years making a name for himself in local theater.
He remembers himself as being a shy kid who didn't speak until he was four years old.
"But my mom says I always made friends on the swing sets once I decided to speak," he says, "so maybe I was less shy than I thought."
Regardless, Arata believes that he and his sister Emily Arata Grillo inherited their parents' musical genes.
"Mom is possibly the most shy person on the planet," he says, "but when she does sing – once per decade, quietly, while alone, for maybe one bar of a song – she's actually super good. Dad is a karaoke legend, so I think we got a mix from our parents."
At an early age he found a creative outlet in music.
"I started playing drums and guitar in third grade," he says, "and since I was never a coordinated athlete, instruments became my main hobby quickly."
Emily was involved in theater while they were young, and when he was in seventh grade at Memorial Park, he followed in her footsteps by auditioning for the school production of Oklahoma!
"I sang a single verse of some cowboy song, stood there awkwardly for probably a whole minute while staring at our music director," he recalls. He finally admitted that he had forgotten the rest of the song and sat back down. "I got cast as Will Parker, so I guess quality over quantity is a thing," he says.
He still counts his sister as his main acting influence.
"Emily has helped me learn as many tricks as I can fit in my brain to not look like an idiot onstage," he says. He has only performed in around a half dozen plays and musicals as an adult and feels fairly comfortable singing and acting.
"My troubles typically appear when they ask me to dance," he admits. "Figuring out how to not trip over myself takes a lot of focused effort."
Otherwise, he feels perfectly at home onstage, having spent countless hours performing with Downstait.
"It's been really helpful for theater because I've been onstage so many times I can't even count them," he says. "It takes a lot of the fear of performance away and helps you read a crowd. The mental aspect of performing is huge, and it translates between the two mediums."
Arata joined Downstait while still in high school, and the band has seen some success on the national level.
"Somehow we got mixed in with MTV and the WWE, and that's helped us to continue putting out music for the last decade or so," he says. "We're still on TV with WWE weekly, and we're in a Cricket Wireless commercial that's currently airing. The Roots once played us on Jimmy Fallon, so it's been an extremely strange ride that seems to be continuing as we're currently writing new music."
He took some time away from performing to earn a bachelor's degree in journalism from Indiana University and a law degree from the University of Oregon in Eugene.
"I didn't study music or theater in college," he says, "but I did drop out twice to go on tour, so I guess I studied music and performance quite a bit during my college years while not going."
During his college years he made time to perform in a number of theatrical productions, including one at the Fort Wayne Civic Theatre, one at the IPFW black box theatre, and three at Arena Dinner Theatre. He also played bass for a few performances of Bat Boy at Arena two seasons ago. "I had to take a break during law school," he says, "because I was swamped."
He has chosen to concentrate all his theatrical efforts on Fort Wayne productions, even while in college.
"Eugene, Oregon, was more into weird performance art with bongos and spoken word poems than actual theater," he says. "I don't miss that aspect of Oregon."
Arata is more interested in the more traditional type of theater – drawing from his own experience and observation when creating characters onstage.
"I start out by picturing a person I believe resembles the character, and then I base the shell of the character on them. The little intricacies of character interactions seem to come a little easier for me when I have a broad idea in mind from the get-go."
The majority of the six roles the actor has played as an adult have been teenagers, including his current role of Peter Pan ("that guys who flies around and fights pirates") in the Arena Dinner Theatre production of Peter and the Starcatcher.
"I'm not sure if it's my personality or my face, but I've only played a person over the age of 20 on one occasion," he says. "I'm not very good at acting like an adult in theater or in real life, I guess. I'm almost 30, playing a 13-year-old."
Arata describes the show as "sort of a prequel to the Disney version [of Peter Pan] we all grew up watching."
He says that despite his youthful appearance, the show has taken a bit of a physical toll on him.
"I get thrown to the ground a lot," he says. "After the first few rehearsals, I came home battered and bruised. But I'm getting the hang of it and building callouses on my entire body. I'll probably survive this production. I'm working through it with ibuprofen."
Nevertheless, he says the experience "has been a blast. It's just a big ol' group of adults making pirate jokes at each other for several hours a day. That's not something you get to be a part of often."
He says that the cast is so packed with talent that "learning by watching everyone has been phenomenal. Except Joel Grillo," he jokes. "That guy is the worst – and also my brother-in-law."
He also has nothing but praise for the show's director, Gloria Minnich.
"She's great," he says. "I've acted in two shows with her, so having her as a director has been a comfortable transition. She has such creative ideas for this show, and it's been great to be a part of that process."
As so many other Fort Wayne actors have experienced, the intimacy of the Arena stage adds an interesting flavor to a performance.
"You walk to the front of the stage, and you're looking directly into the eyes of some person," he says. "It's kind of nice to be able to feel the demeanor of the room while you're up there. Terrifying, but nice."
Although he doesn't have aspirations to making performance his career for the rest of his life, he is continuing to write music and perform with Downstait and has no plans for slowing down his theater participation. His eyes, however, are on a different prize.
"I get to start studying for the bar immediately after this show ends," he says. "My career aspirations are to pass the bar on my first try and hopefully retire before I'm 90."


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Information About Commack
Commack is a hamlet and census designated place (CDP) that roughly corresponds to the hamlet by the same name in the towns of Huntington and Smithtown in Suffolk County, on Long Island, in New York, United States, on Long Island. The CDP's population was 36,124 at the 2010 census.
The name "Commack" comes from the Secatogue Native American Tribe who lived on the South Shore of Long Island between Copiague and Bayport. The Secatogue named their northern lands in the center of the island Winnecomac which means "pleasant lands." The name may have been inspired because of the towns flat lands with rich soil, and thick oak forests abounding with plants and wildlife. From its earliest days, Commack or originally spelled as Comac was known for its fertile soil which made it the perfect land for farming. Also the land had an abundance of game and wood.
Today all of Commack is settled and suburbanized and, like most unincorporated areas of Long Island, does not have a true, walkable downtown or "Main Street".
Learn more about Commack.
Additional Links for Commack
Useful links for Commack, NY
Open a Commack, NY map
Find the Commack, NY United States Post Office
Locate nearby Commack, NY pharmacies
View the current Commack, NY weather report
Browse a list of Commack, NY public and private schools
Commack, NY is located in Suffolk county in New York State


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adebayo akinfenwa fifa 20
© www.fifaindex.com 2020 - Terms Of Service - Cookie Policy. Top 20 Strongest Players. NealGuides - FIFA 20 Tutorials & in-depth Guides 91,147 views So it's no surprise that on FIFA 20, Akinfenwa - known as 'The Beast' - was named as the strongest player on the game with a 97 rating, two higher than any other player. The now-Championship forward has maintained his strength of 97 from FIFA 20, although he has dropped again in pace. (POST PATCH) - Duration: 13:03. The cult hero helped Wycombe Wanderers secure … Join the conversation using #FIFARatings on social media! wyp100. Please enable cookies to view. He is currently 38 years old and plays as a Striker for Wycombe Wanderers in England. The top strikers and forwards in FIFA 21 and where to find them. Akinfenwa's height is 178 cm cm and his weight is estimated at 110 kg kg according to our database. Never miss a thing. Today can?t get any better. Adebayo Akinfenwa's FIFA 20 Overall Rating (OVR) is 65 with Potential Rating (POT) of up to 65. Thomas M�ller, ugly football, and you, Lionel Messi is still the best footballer in the world, according to FIFA 21, There's more than a bit of Football Manager in FIFA 21's Career Mode, FIFA 21 potential wonderkids: the best career mode youngsters and hidden gems. Wycombe Wanderers legend Adebayo Akinfenwa is now a FIFA 20 Ultimate Team hero card - and it's got an incredible 99 physicality. Akinfenwa sounded delighted at the news in a tweet. He likes news, interviews, and more news. ?#BeastMode #Beast20 @wwfcofficial pic.twitter.com/yf9iTJxXNS. Adebayo Akinfenwa is an Englishman professional football player who mainly plays at Striker position for Wycombe Wanderers at the EFL League One in England. Akinfenwa is an English football cult hero, and is famous within the FIFA community for being Ultimate Team's strongest player. Anyone who has played FIFA in the last five years will know the name Adebayo Akinfenwa. Akinfenwa has got a 2-star skillmoves rating. The veteran striker hit the headlines earlier this month after helping his club secure promotion to the Championship by beating Oxford United at Wembley. Now, EA Sports has rewarded Akinfenwa for his heroics with an Ultimate Team hero card - and it's pretty incredible. He's Akinfenwa. Klopp was game, and offered his congratulations in a video message that went viral. Akinfenwa has got a 2-star skillmoves rating. EA launches FIFA 21 PS5 and Xbox Series X and S free upgrade early, EDM-themed Rocket League season 2 blasts off next week, Zlatan Ibrahimovic's agent hangs up in spicy radio interview after saying FIFA 21 image rights row is "all about money", EA hits back in FIFA 21 image rights row as player agents threaten legal action, Football agents "tried to bribe" Football Manager into giving better ratings, FIFA 21 best strikers - the best ST and CFs in FIFA. EA Sports creates a hero card in FIFA 20 to Adebayo Akinfenwa, the veteran player who managed to advance to the League Championship with the Wycombe Wanderers. FeatureFIFA's greatest obstacles? He prefers to shoot with his right foot. He has been named the strongest footballer in the world. The Wycombe striker will surely retain his title as FIFA's strongest player. No part of this site or its content may be reproduced without the permission of the copyright holder. They love kicking a football almost as much as the pursuit of a new bench press PB. This content is hosted on an external platform, which will only display it if you accept targeting cookies. Hero cards are one-offs dished out for players who achieve something remarkable. Akinfenwa also runs a clothing label named 'Beast Mode On.' Add the latest transfer rumour here. In his post-match interview, Akinfenwa called on Liverpool boss Jurgen Klopp to celebrate with him on WhatsApp. Adebayo Akinfenwa - 97 … Mexican Fifa 20 fanatics travel 5,500 miles to watch Adebayo Akinfenwa in League One clash between Wycombe and Tranmere. In FIFA 20, Akinfenwa's base card has 97 strength, putting him ahead of Aston Villa striker Wesley, Napoli defender Kalidou Koulibaly and Inter Milan forward Romelu Lukaku, who each have 95 strength. He also likes Street Fighter more than anyone can get him to shut up about it. The Wycombe beast, 37, clocks in at a … Adebayo Akinfenwa 's latest FIFA 20 Ultimate Team card comes with a ridiculous 99 physicality. Wycombe now have two of the world's top five strongest players on FIFA 20 as Uche Ikpeazu teams up with Adebayo Akinfenwa By Sean O'Brien 17th August 2020, 9:39 pm THE strongest players on FIFA 20 have been released – with Adebayo Akinfenwa beating Romelu Lukaku and Aston Villa man Wesley to the top spot. Are there rumours this player is going somewhere else? They include boosted stats, and that's certainly what Akinfenwa has enjoyed here. Mexicanos viajan 5,000 millas para conocer a la estrella del FIFA 20, Adebayo Akinfenwa. Are u crazyyyyyyy the man, the myth, the legend sent me a Watsapp. Adebayo Akinfenwa 65 - live prices, in-game stats, comments and reviews for FIFA 20 Ultimate Team FUT. His hero card has 99 strength and 99 physicality - the highest rating possible for each category. 2d I?ve gotta say there were 20+ Wycombe players and staff who are all hero?s, but best believe I?m loving my Hero card. For more information, go here. FIFA 20 star Akinfenwa: Mexican fans travel 5,000 miles to see 'Beast Mode' activated 273d Chris Wright Arsenal welcome fans back inside the Emirates after nine months apart Saheed Adebayo Akinfenwa (born 10 May 1982) is an English professional footballer who plays as a striker for Championship club Wycombe Wanderers.. Akinfenwa's professional breakthrough came at Doncaster Rovers, having spent time up until then in the lower leagues of English football as well as spells in Lithuania and Wales.Following a short but successful time at Doncaster, Akinfenwa moved … 280d Chris Wright. Deputy Editor	| Saheed Adebayo Akinfenwa (born 10 May 1982) is an English professional footballer who plays as a striker for EFL Championship club Wycombe Wanderers. His best stats are: Strength: 97, Heading: 73, Balance: 71, Shot Power: 70, Aggression: 69. Adebayo Akinfenwa, 38, from England Wycombe Wanderers, since 2016 Centre-Forward Market value: €150Th. A quick fire Q&A with Adebayo Akinfenwa, AKA 'The Beast' and the strongest man in FIFA! Here are the 20 players with the highest strength rating in FIFA 21. Adebayo Akinfenwa is renowned in the footballing universe for his incredible strength and size. And he's only got 60 pace, so don't expect him to sprint past a defender or track back. Liam Taylor; Feb 29 2020, 13:29 ET; TWO Mexican fans were such big admirers of Wycombe cult-hero Adebayo Akinfenwa that they travelled 5,500 miles across the world to watch him in action. FIFA 20: Adebayo Akinfenwa se convierte en el futbolista con mayor físico del juego Luego de lograr el ascenso a Championship con Wycombe, el … FIFA 21 presenta uniforme inspirado en el Chavo del 8. His overall rating in FIFA 20 is 65 with a potential of 65. His overall rating in FIFA 20 is 65 with a potential of 65. FIFA 20 - Top 5 Meta Advanced SKILL MOVES To Beat Your Opponent & Get More Wins! Adebayo Akinfenwa was born on May 10, 1982. Cold War and Warzone Season 1 release time. Of course, the card is weak in other areas. Join the discussion or compare with others! Wycombe Wanderers legend Adebayo Akinfenwa is now a FIFA 20 Ultimate Team hero card - and it's got an incredible 99 physicality. He is currently 38 years old and plays as a Striker for Wycombe Wanderers in England. He is currently 38 years old and plays as a Striker for Wycombe Wanderers in England. 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Writing is too important because, though forms and structures will differ, writing is the path to power for those born without power. This importance lies not in how to write a "five‐paragraph essay" or a "compare and contrast" book review but in the capability to clearly communicate visions both personal and collaborative. Whether the work is a tweet that generates action when that is needed, or a text message to an employer, or the ability to convince others in the political realm, or the expression of one's identity in a form that evokes empathy in those without similar experience, "communicating" "well" is a social leveler of supreme importance.
In both cases, methodology become less important than process. Our students read on paper, or through audio books, or through text‐to‐speech, or by watching video, or by seeing theater – or by observing their world. They write with pens, keyboards large and small, touchscreens, or by dictating to their phones or computers, or by recording audio, or by making videos, or by writing plays or creating art, or playing music. We do not limit the work by attacking those with disabilities or even inabilities – or even other preferences, because that robs children of both important influences and of theira individual voices. Multiplicities are an intention: We build the best collaboration, the deepest learning, when we expand the opportunities for complex vision.
Thus we begin by moving the teaching of writing from the training of a specific skill set toward an interpersonal art form that flows from students and builds communities. Then, through the reimagining of teaching places into "learning spaces," we craft "studios" where all the technologies of school – time, space, tools, pedagogies – liberate and inspire rather than deliver and test. Then, using those recrafted technologies, we allow communication learning to flow.
Source: Socol, Ira. Timeless Learning: How Imagination, Observation, and Zero-Based Thinking Change Schools (Kindle Locations 3725-3739). Wiley. Kindle Edition.


Competent Authorities for Medical Devices were established to enhance collaborative working, communication and surveillance of medical devices across Europe.
With the new year approaching, CAMD were looking for a modern website rebuild to bring thier existing Drupal website up to date and enhance their internal network using more recent technologies. The overall goal was to replicate the existing data in a new bespoke internal platform with a refreshed public front-end.
CAMD are now able to internally manage their documents and members effectively, all from one management system.
Through multiple design meetings and careful innovative blueprinting, we were able to bring this outdated project to life by strategizing an efficient plan, from start to finish.
Our development team made effective use of the latest technologies to provide the perfect solution. This included scaleable features such as; user profile management, custom user groups & restricted content, collaborative document handling, internal messaging and a bespoke user dashboard interface.
As a result of our calculated approach to this work, CAMD can now enjoy the luxury of a refined CMS to make their daily tasks that little bit easier.