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The G1 has great call quality and does a good job of melding hardware with the Android operating system.


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text:
Teacher resigns after sex allegation
By Erika Hobbs and Sentinel Staff Writer
A social-studies teacher at Oak Ridge High School resigned this week after she was accused of having sex with a female student in a classroom during the late-morning hours of the school day.
Allison Reopel, 25, of Orlando, resigned Wednesday, six days after a computer technician reported that he walked in on the teacher and the 18-year old student, school-district officials said.
"In no way does my resignation confirm or deny any current allegations against me," Reopel wrote in a letter to Orange County Public Schools officials.
The incident is being investigated by the Orange County Sheriff's Office and could be taken up by the State Attorney's Office, district officials said.
District spokesman Dylan Thomas said Reopel was relieved of her duties April 13, one day after the incident. Because she resigned, no disciplinary action was taken against her.
However, she will be reported to the Florida Education Practices Commission, which investigates allegations of wrongdoing and will determine whether Reopel should continue teaching in the state.
Thomas said the district's own investigation of the case could continue for at least one more week.
School Board attorney Frank Kruppenbacher said that the superintendent and his staff will discuss on Monday what actions to take concerning the student.
Reopel, who began working for the district in August 2005, also was an assistant softball coach at Oak Ridge.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Why does HashMap::get_mut() take ownership of the map for the rest of the scope? I have the following code that inserts some values into a HashMap and then gets them back out:
use std::collections::HashMap;

fn things() {
    let mut map = HashMap::new();
    map.insert(5, "thing");
    map.insert(4, "world");
    map.insert(1, "hello");
    let mut thing = map.remove(&5);
    let mut world = map.get_mut(&4);
    let mut hello = map.get_mut(&1);
}

Attempting to compile this code gives the following error:
error[E0499]: cannot borrow `map` as mutable more than once at a time
  --> src/main.rs:10:21
   |
9  |     let mut world = map.get_mut(&4);
   |                     --- first mutable borrow occurs here
10 |     let mut hello = map.get_mut(&1);
   |                     ^^^ second mutable borrow occurs here
11 | }
   | - first borrow ends here

After perusing the API docs for both the remove() and get_mut() methods (fortunately they are pretty close to each other!) there is nothing that stands out to me from the method signatures why the remove() method does not mutably borrow the map for the rest of the current scope while the get_mut() method does.
The other piece of data that I have that also mystifies me is that this code compiles:
use std::collections::HashMap;

fn things() {
    let mut map = HashMap::new();
    map.insert(5, "thing");
    map.insert(4, "world");
    map.insert(1, "hello");
    let mut thing = map.remove(&5);
    map.get_mut(&4);
    let mut hello = map.get_mut(&1);
}

Not storing the result of the first call to get_mut() doesn't cause the map to be mutably borrowed for the rest of the scope?  How could I have known this from looking at the documentation?  Am I missing something else?

A: This error is a limitation of the implementation of the borrow checker before non-lexical lifetimes. With those enabled, the original code will work as-is:
use std::collections::HashMap;

fn things() {
    let mut map = HashMap::new();
    map.insert(5, "thing");
    map.insert(4, "world");
    map.insert(1, "hello");
    let mut thing = map.remove(&5);
    let mut world = map.get_mut(&4);
    let mut hello = map.get_mut(&1);
}

fn main() {}

This is because the compiler is smarter and can see that you aren't using world anymore by the time you get to map.get_mut(&1), so it doesn't need to have a valid reference anymore.
You can get equivalent code in previous versions of Rust by adding an explicit scope:
let mut thing = map.remove(&5);
{
    let mut world = map.get_mut(&4);
}
let mut hello = map.get_mut(&1);

Why does HashMap::get_mut() take ownership of the map

It absolutely does not do that. Ownership is a precise term in Rust code. Note that the error message specifically says

previous borrow of map occurs here

A borrow is not ownership. If I borrow your car, I don't own your car.
Your real question is "why does it borrow it for the rest of the scope". Let's look at the signature:
fn get_mut<Q: ?Sized>(&mut self, k: &Q) -> Option<&mut V>
where
    K: Borrow<Q>,
    Q: Hash + Eq,

In words, this could be read as

Given a mutable reference to a HashMap (&mut self) and something that can be used to find the key (K: Borrow<Q>, Q: Hash + Eq), return a mutable reference to the value if one matches (Option<&mut V>)

However, that returned mutable reference will be changing something in the HashMap, that's why it's a mutable reference at all. You are only allowed to have multiple immutable borrows OR one mutable borrow at a time. This prevents writing code that causes inconsistencies and safety issues.
Let's look at remove:
fn remove<Q: ?Sized>(&mut self, k: &Q) -> Option<V>
where
    K: Borrow<Q>,
    Q: Hash + Eq,

This returns an owned value, not a reference into the HashMap. Once the method is done, the borrow of the map is over.

redpajama_set_name: RedPajamaStackExchange


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Namaste. I honor the place in you in which the entire Universe dwells. I honor the place in you which is of love, of light, of truth, and of peace. When you are in that place in you, and I am in that place in me, we are One.


Jehovah's Witnesses Are In Apostasy!!!
BEING NGOs FOR THE UNITED NATIONS?
Watchtower Magazine, June 1, 1991, p. 17, Their Refuge—A Lie!
10 However, she has not done so. Instead, in her quest for peace and security, she insinuates herself into the favor of the political leaders of the nations—this despite the Bible's warning that friendship with the world is enmity with God.(James 4:4) Moreover, in 1919 she strongly advocated the League of Nations as man's best hope for peace. Since 1945 she has put her hope in the United Nations.(Compare Revelation 17:3, 11) How extensive is her involvement with this organization?
"PRAYER AND MEDITATION AT THE UNITED NATIONS"
When you make a close comparison of the two above quotes, you will clearly see the Watchtower LIFTED their quote from Mr. Muller's statement. And it is clear from reading the entire quote from Mr. Muller, he was specifically referring to NGO participation.
Remember This Issue of the Watchtower???
and NOT apostasy for the Watchtower Society & Jehovah's Witnesses, who were also voluntary NGOs for the UN for ten (10) years, all during the 1990s???
Title of the infamous article studied week of July 8th, 1991 shown above.
Key paragraphs about apostasy with United Nations shown above.
The above quote in paragraph 11 of the Watchtower, June 1, 1991 article (noted above) is not credited by the Watchtower Society of course, but it appears to have been taken from the 1982 book, NEW GENESIS: SHAPING A GLOBAL SPIRITUALITY (ISBN # 1-680465-04-3) chapter 6, under the subheading, "Prayer And Meditation At The United Nations" by Robert Muller.
Thus in reality, all the while the Watchtower Society was condemning the Catholic Church for being NGOs with the United Nations, they themselves were at the SAME TIME hypocritically applying for membership as NGOs with the United Nations in the year of 1991! -- See Luke 12:1-3; Galatians 5:9 NWT.
that may be useful in this regard.
Back To Introduction to the "Disgusting Thing"


text:
News / Foreign Policy
Ex-director CIA led 'cover-up' of Kennedy assassination: Report
Monday, 12 October 2015 3:16 PM [ Last Update: Monday, 12 October 2015 4:11 PM ]
Former US president John F. Kennedy (center) with CIA directors Allen Dulles (left) and John McCone
A declassified report by the US Central Intelligence Agency (CIA) has concluded that the spy agency's former director withheld information about the assassination of former President John F. Kennedy.
The CIA report, which was written in 2013 and quietly declassified last fall, concludes that John McCone, who led the CIA when Kennedy was fatally shot in 1963, kept information from a federal commission that was investigating the assassination.
The report's author, CIA historian David Robarge, writes that McCone and other top CIA officials were part of a "benign cover-up" to keep information from the Warren Commission, according to Politico Magazine.
The President's Commission on the Assassination of President Kennedy, known unofficially as the Warren Commission, was established by former President Lyndon B. Johnson in November 1963 to investigate the assassination of Kennedy.
Robarge writes that McCone and other CIA officials were "complicit" in keeping "incendiary" information from the commission.
He also wrote that the CIA sought to keep the commission focused on what the agency believed at the time was the "best truth… that Lee Harvey Oswald, for as yet undetermined motives, had acted alone."
The commission's final report released in September 1964 agreed with McCone's assessment that Oswald acted entirely alone in assassinating Kennedy.
However, the US House of Representatives Select Committee on Assassinations concluded in 1978 that the investigations by the Warren Commission were flawed and that Kennedy was probably assassinated as a result of a conspiracy.
Many researchers are also unconvinced by the official government account and argue that Oswald was part of a conspiracy to kill Kennedy, perhaps in connection with Israel, Cuba or the former Soviet Union.
Israel had a motive to kill Kennedy because the president was opposed to the regime's nuclear weapons program at Dimona which he believed could instigate a nuclear arms-race in the Middle East.
Kennedy encountered tensions with the Israelis regarding the production of nuclear materials in Dimona.
Israel resisted pressure by the Kennedy administration to open its nuclear facilities to International Atomic Energy Agency (IAEA) inspections and misled American scientists who visited Dimona in 1962.
US CIA JFK
MORE FROM Foreign Policy
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Iran tells UN it reserves right to firmly respond to Israeli aggression 1hr
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VIDEO | Tears and anger as US police victim Tyre Nichols laid to rest in Memphis 1hr
US Republicans seek to oust Ilhan Omar from panel over comments on Israel 1hr


text:
Will Massachusetts Sports Fans Be Able to Bet on College Sports?
Written By: Amber Hoffman
Before we answer that question, it's important to remember that sports betting is still not legal in the state of Massachusetts. Even though online betting juggernaut DraftKings is based in Boston. And, if or when that happens, college sports fans might be disappointed.
In July, the Massachusetts House of Representatives passed Bill H3977. Which would open the door for wagering on professional and college sports (though not on individual prop performances), esports, and video games, either online or at in-person sportsbooks.
However, there's also Senate Bill S269, which currently resides in the Ways and Means Committee. This does not include college sports wagering, but has been reported to be a bill Massachusetts Governor Charlie Baker would likely sign.
Talking Integrity
Even the casual sports fan knows how much of a moneymaker college sports, such as football and men's basketball, are for their respective schools. However, the matter of integrity also comes into play. The latter appears to be a major hurdle in terms of college sports wagering seeing the light of day in the Bay State.
Massachusetts is home to some of the most prestigious universities in the world, like Harvard and Boston University. Those two schools, along with the likes of Boston College and UMass, have vocally voiced their concern regarding the legalization of college sports betting.
Students betting on their own schools, added to the usual pitfalls of potential gambling addiction, is a worry thrown onto the shoulders of administrators. Not to mention, the realistic possibility that a player from an in-state school can wager on his or her own contest, is naturally a fear.
Presidents and athletic directors from eight Massachusetts colleges and universities that offer Division I sports stated that legalizing betting on college athletics would lead to "unnecessary and unacceptable risks to student-athletes, their campus peers and the integrity and culture of colleges and universities in the Commonwealth."
Quite The Quandary
It's quite the predicament state leadership finds itself in when it comes to waging on college sports. Though, if any wagering bill passes without college sports in the mix, it would not be completely unprecedented.
In Illinois, for instance, wagers are unable to bet on games featuring Division I state schools like the University of Illinois, Northwestern, Northern Illinois, or DePaul. However, the state could be reconsidering that stance. Which would be music to the ears of sports bettors throughout the Land of Lincoln.
Meanwhile, back in Massachusetts, fans continue to wait, not only for legalized sports wagering to finally find a place in their state, but for college betting to come along for the ride. In the meantime, Massachusetts residents can jaunt over to nearby states such as New Hampshire or Rhode Island to bet on Boston College football this fall or put some action on UMass hoops later in 2021.
But, as Massachusetts Rep Andy Vargas told NBCBoston.com in July: "I represent a district which borders New Hampshire. In Haverhill, you can literally walk across the border into New Hampshire and place a bet. I know that my constituents who partake in sports wagering would rather place these bets in their homes and in their own state."
Amber Hoffman
Amber Hoffman is Managing Editor of MassachusettsCasinos.com. A recovering attorney, she's spent almost a decade developing and managing websites and writing for a variety of industries. Amber married into a Red Sox family and has embraced the Sox ever since.


Estonia: The first five finalists of Eesti Laul 2017.
The national broadcaster had made a call for submission of songs early September 2016 with a deadline finishing on 1st of November. A special jury afterwards cut the list down to a total of 20 acts that would be divided in two groups , ten artists for each one of the two semi finals to be held. Five artists from each semi final are to qualify for the grand final.
After a first round of voting by a special jury and public voting , 4 contestants where qualified to the final. Elina Born, Ivo Linna, Lenna Kuurmaa και Whogaux & Karl-Kristjan were the ones to make it first to the final. The fifth and last one was determined, exclusively by televoting after a final round among the rest 6 artists. The last ticket went to Ariadne who won the public vote on this round of voting.
Next week 18/2 the second group of 10 artists will compete in the 2nd semi final and another pack pf 5 artists will qualify to the final that will take place on March 5.
Estonia 2017: Second Semi Final results of Eesti Laul 2017.
« Poland: The 10 finalist of Krajowe Eliminacje 2017.


text:
Diversity News Featured Articles
Attack on unions shows why we need a new social contract governing work
IMDiversity	5 years ago Comments Off on Attack on unions shows why we need a new social contract governing work	702
Here are three high-priority ideas that can help us reach a new compact and deserve broader discussion.
By Thomas Kochan
Thomas Kochan Professor of Management, MIT Sloan School of Management
The Conversation, January 13, 2016 — The U.S. Supreme Court heard a case this week that may deal a significant blow to labor unions and shows why it's vital, to my mind, to come up with a new social contract governing work.
A case before the Supreme Court could deal a major blow to unions. Reuters
The case involves 10 California teachers who argue they can't be forced to support a public union they declined to join despite receiving the benefits gained from collective bargaining. It's part of an ongoing conservative effort to weaken unions in the U.S.
A ruling in their favor, which appears likely, would be a setback not just for organized labor but also for conversations now under way over how to update the full range of employment policies and institutions to better match today's world of work.
That means it's urgent that Americans continue discussions like those held last month at a gathering of leaders from business, labor and elsewhere to discuss the future of work. At the meeting, Secretary of Labor Tom Perez challenged attendees to negotiate a new social contract governing labor, which he called Social Compact 2.0.
Labor Secretary Perez argues we need Social Compact 2.0. Edward Kimmel/Flickr, CC BY-SA
What happened to social compact 1.0?
The secretary's use of the 2.0 tagline reflected the fact that the U.S. once had a viable social contract or compact, which lasted from about the end of World War II up to 1980.
Labor legislation passed in the New Deal (minimum wages and overtime protections, social security, unemployment insurance and the right to unionize) provided the foundation for that social contract, and collective bargaining made it work by negotiating wage increases in tandem with productivity growth.
But at least in part because those policies and practices could not cope well with developments since 1980 – such as globalization and corporate short-termism – the country has experienced three decades of wage stagnation, rising income inequality and the erosion of the social safety net that was designed to ensure basic protections and minimum employment standards.
Restoring such a safety net, which would be further eroded if the Supreme Court rules against the unions, will require broadening the circle of debate to engage the powerful interest groups that don't necessarily share the view that changes are needed.
Given the hopeless gridlock in Congress on labor policy issues, the best path forward might be to focus on private sector leaders and those on the front lines of innovations that might just help identify the features of a new social compact.
I've argued in my own work that national leadership on this front is long overdue, and I'm delighted to see the attention and passion Secretary Perez is giving this issue.
Here are three high-priority ideas highlighted by participants at his gathering that can help us reach a new compact and deserve broader discussion.
How to wean social benefits from employment
A major point of debate at the meeting was whether or not the economy, business and workforce would all be better off if we could sever the safety net from employers. That is, should we separate the funding and coverage for benefits such as health insurance, retirement savings and sick and family leave from individual employment relationships?
President Barack Obama highlighted this idea in his last State of the Union address, arguing such "basic benefits should be as mobile as everything else is today."
The U.S. chose to link health care and pension benefits to employers during and after World War II in an era when the image of the employment relationship was of an individual (mostly male) working full-time for a large company for an extended period of time, and perhaps a full career with a wife at home taking care of family and community responsibilities.
Obviously those conditions no longer capture today's workforce diversity, work-family responsibilities, tenure and mobility patterns or the variety of full time-part-time, contractor, franchise or temporary work settings.
How to separate benefits from employment status will be difficult, but it should not be impossible.
My own private conversations with human resource professionals from some of America's largest companies suggest their organizations want to get out of the health care and retirement security business entirely.
How can we do this in ways that enhance health care and retirement security rather than simply leave the workforce to fend for itself?
A new way to regulate and enforce standards
Another area of discussion was how to modernize regulation and enforcement of employment standards.
The Department of Labor's wage and hour administrator, David Weil, put this issue on the table in early 2014 in a paper discussing what he has labeled the "fissured" workplace. In other words, the growth of alternative forms of work – such as contractors, temporary staff and on-demand employees – has left many workers outside the standard safety net of minimum wages, overtime and other New Deal-era employment policies.
The good news is the rise of Uber and other on-demand platforms has put this issue front and center in the national media and is generating new policy proposals to fix it.
And in Seattle and California, it is generating efforts to extend collective bargaining and coverage of basic employment standards to Uber drivers.
It is important to let these efforts play out and evaluate their effects. Will drivers actually mobilize and negotiate, or are they as happy with their individual arrangements as Uber believes? Will treating drivers as employees rather than contractors ruin Uber's business model or lead to further innovations that keep the new platforms growing while providing a more fair distribution of the profits to drivers?
My prediction, based on the historical evidence from when collective bargaining first became a powerful force in American industry, is that these new businesses will adapt and further innovate in ways that allow them to continue to grow, prosper and share their prosperity with those who do their work.
Supporters cheered as Seattle approved a measure to let drivers for Uber and Lyft unionize. Reuters
Breaking the chains of our ossified labor law
Unlike the debate at the Supreme Court, participants in this meeting focused on how to rebuild bargaining power so workers have an effective voice in shaping the future of work. There was a crucial breakthrough over this issue.
In the past this issue was framed narrowly as a zero-sum game over whether or not to strengthen or reform existing rules governing union organizing and collective bargaining. This approach has consistently failed to break the business-labor gridlock over our our ossified labor policy and is not likely to be any more successful in the future.
Many at the meeting called for new approaches, reflecting developments emerging across the country, some of which go well beyond the procedures and doctrines enshrined in our 1935 National Labor Relations Act.
Consider, for example, the fight for a US$15 minimum wage that is going on in a wide variety of "negotiations" involving community groups, unions, local governments and businesses without any formal legally protected structure or process. Worker centers, often allied with religious and immigrant coalitions, are mobilizing to enact living wage ordinances and community benefit agreements in cities across the country.
Other visible examples of groups without formal bargaining powers negotiating for better treatment include the Freelancers Union, Restaurant Opportunities Centers, the Taxi Workers Alliance and the Domestic Workers Alliance.
"Letting a thousand flowers bloom" makes good sense, but we should also ask the tough question that labor leader David Rolf keeps posing: are these efforts sustainable, will they grow from isolated examples to a scale big enough make a national difference and are they able to replace the bargaining power for workers that collective bargaining provided under the old social contract?
From ideology to evidence-based
Now is the time to go beyond speaking to the choir and engage the broader stakeholders in business, labor and government who are not yet convinced of the need for fundamental, forward-looking changes in workplace policies and labor market institutions.
But this will work only if we replace ideologically driven attacks against unions – like those before the Supreme Court this week – with hard evidence. That evidence can be gained from tracking the many local experiments under way to build on and improve what workers, unions, employers and government leaders are doing to shape the workplace of the future in ways that work better for all.
By doing so, we might just identify the features of a Social Compact 2.0 a majority of Americans can support and take to a national level – if and when the political stars align to make this possible.
World mourns Mandela, struggles to find the words
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How to avoid the 6 most common mistakes of job searching
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text:
60S ribosomal protein L41 is a protein that in humans is encoded by the RPL41 gene.

Ribosomes, the organelles that catalyze protein synthesis, consist of a small 40S subunit and a large 60S subunit. Together these subunits are composed of 4 RNA species and approximately 80 structurally distinct proteins. This gene encodes a ribosomal protein that is a component of the 60S subunit. The protein, which shares sequence similarity with the yeast ribosomal protein YL41, belongs to the L41E family of ribosomal proteins. It is located in the cytoplasm. The protein can interact with the beta subunit of protein kinase CKII and can stimulate the phosphorylation of DNA topoisomerase II-alpha by CKII. Two alternative splice variants have been identified, both encoding the same protein. As is typical for genes encoding ribosomal proteins, there are multiple processed pseudogenes of this gene dispersed through the genome.

References

External links

Further reading

Ribosomal proteins

redpajama_set_name: RedPajamaWikipedia


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Simply unmounting a filesystem is not the ideal way to remove an external USB/firewire/SATA drive in Linux. This tutorial explains why and gives a solution.
This seemed to work pretty well–at the very least, I wasn't losing data–except the drive made a strange sound when I powered it off. It wasn't a normal drive spin down sound; it was louder and shorter. So, I googled for authoritative instructions on using external drives with Linux. While most sources suggest doing exactly what I did, it's not ideal.
At this point, the drive is removed from Linux's SCSI subsystem and it should not be spinning. It's safe to unplug and turn off.
Using scsiadd directly can be inconvenient because it requires looking up the host, channel, id, and lun of the drive. I wrote a short script that will take a normal Linux device file like /dev/sdb, figure out the correct arguments to scsiadd, and run scsiadd -r. I use this script in my larger backup script.
echo "Error: scsiadd not installed"
echo "Error: could not find device: $1"
It does require the lsscsi command to be present on the system.


a.    General. Your title shall be "Chief Operating Officer" of Studio.
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text:
AAPT gets chatty with broadband
Nadia Cameron (ARN) 29 October, 2003 17:13
AAPT has extended its smartchat brand into the broadband market with the launch of a new national ADSL service for metropolitan users.
Until December 31, existing telephony customers will be able to access ADSL services with AAPT for $49.95 per month, based on a 256Kbps/64Kbps plan. This includes 300MB of downloads.
Entry-level plans for those without an AAPT telephony account start at $59.95 per month for a 256Kbps/64Kbps speed service including 500MB of downloads. The ISP is also offering plans based on 512Kbps/128Mbps and 1500Kbps/256Kbps access speeds, starting from $74.95 with a 1GB download usage allowance per month.
AAPT's heavy user "smart power" plan, which is based on 1500Kbps/256Kbps download and upload access speeds, is available for $179.95 per month and comes with a monthly download limit of 10GB.
All plans feature six email addresses and 20MB of Web space, as well as free data upload. Additional data usage across all AAPT smartchat broadband plans will be charged at 14.3c per megabyte.
The ADSL service is initially available to metropolitan areas. Coverage to outer-metropolitan and regional areas will become available in late November.
A self-install starter kit for new broadband customers will cost $199 regardless of the length of the customer's contract. Those who opt for a 24-month contract will not be charged a connection fee, but those wishing to sign up for a 12-month or 3-month contract will pay an additional $99 and $169 respectively. Professional installation of a smartchat ADSL service regardless of the contract terms will incur a one-off $160 fee. AAPT Australian media relations manager, Andrew Bristol, said self-install kits were currently only available through AAPT direct.
"[But] we are aiming to broaden our distribution reach to our retail channels," he said.
Although AAPT states its smartchat broadband service is being provided by AOL7, a joint venture between AAPT, Channel 7 and America Online (AOL) — there are no plans to share online content between the AOL7 Australian broadband service and AAPT's new smartchat broadband service, Bristol said.
Despite its introductory discount for existing telephony customers, the plans are more expensive than those offered by many of its competitors.
For example, OzEmail's ADSL broadband offerings start from $48.95 for a 256Kbps/64Kbps plan and feature a 500MB monthly download limit, while South Australian-based ISP iiNet's 256Kbps/64Kbps ADSL service is available for $49.95 with a 1000MB download allowance per month during both on and off-peak times.


text:
J Clin Med Res
Journal of Clinical Medicine Research, ISSN 1918-3003 print, 1918-3011 online, Open Access
Article copyright, the authors; Journal compilation copyright, J Clin Med Res and Elmer Press Inc
Journal website http://www.jocmr.org
Volume 7, Number 4, April 2015, pages 248-252
Serum Survivin Increases in Prolactinoma
Fatma Dilek Dellala, e, Mutlu Niyazoglub, Suheyla Gorara, Esranur Ademoglua, Zehra Candana, Handan Bekdemira, Yalcin Haciogluc, Fatih Oner Kayad
aDepartment of Endocrinology, Ankara Training and Research Hospital, Ankara, Turkey
bDepartment of Endocrinology, Istanbul Training and Research Hospital, Istanbul, Turkey
cDepartment of Family Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey
dDepartment of Internal Medicine, Istanbul Training and Research Hospital, Istanbul, Turkey
eCorresponding Author: Fatma Dilek Dellal, Oguzlar Mah. Ilhami Soysal Sok. No. 4/7 06520 Cankaya, Ankara, Turkey
Manuscript accepted for publication January 21, 2015
Short title: Serum Survivin in Prolactinoma
doi: http://dx.doi.org/10.14740/jocmr2098w
Background: Prolactinoma is the most common adult pituitary adenoma. Survivin is a member of the family of inhibitors of apoptosis proteins. Its expression is observed in many tumors. Survivin expression has shown in prolactinoma tissue before but no study exists showing serum survivin level. The aim of the present study was to investigate serum survivin levels in patients with prolactinoma and demonstrate its value in diagnosis of the disease.
Methods: The group of patients consisted of 25 women, aged from 17 to 51 years. As a control group, 21 healthy women, aged from 22 to 45 years were included. Twenty patients had microprolactinoma, while five patients had macroprolactinoma. All patients had received dopamine agonist treatment. Serum survivin levels were measured in all of the groups.
Results: Survivin levels were significantly higher in prolactinoma patients compared to controls (19.04 (10 - 38) pg/mL; 15.05 (8 - 22) pg/mL; P = 0.042). There was no difference between microadenoma and macroadenoma patients in survivin levels (19.22 (10 - 38) pg/mL; 18.40 (16 - 22) pg/mL; P = 0.914). In correlation analysis, survivin was not correlated with other parameters.
Conclusions: We consider that higher survivin levels might be a molecular marker predicting the presence of prolactinoma and may be useful for the diagnosis. But large-scale research is needed to clarify its role in diagnosis of prolactinoma patients.
Keywords: Survivin; Prolactinoma; Microprolactinoma; Macroprolactinoma; Pituitary neoplasms
Survivin, a member of the inhibitors of the apoptosis (IAPs) protein family, is encoded by BIRC5 gene located 17q25 in the human sequence. It is the smallest protein of the IAPs protein family, a 142 amino acid and a 16.5 kDa protein [1]. It has a single baculovirus IAP repeat (BIR) domain, which is responsible for protein recognition and interaction [2]. It regulates cell proliferation and apoptotic cell death while enhancing angiogenesis [2, 3].
Expression of survivin increases during embryogenesis; however it decreases after birth with the exception of thymus, hematopoietic progenitor cells, and basal epithelial cells of the colon [1]. Furthermore its formation was revealed in many of human neoplasms such as breast, stomach, non-small cell lung, colorectal, esophagus, ovary, pancreas, bladder, prostate, larynx, papillary thyroid, endometrium, cervix, glioma, neuroblastoma, melanoma, astrocytoma, and meningioma. Increased survivin expression is associated with clinicopathologic variables of aggressive disease and shows a strong correlation with shorter disease-free period in most studies [1, 4-16].
Pituitary adenomas are one of the most frequent intracranial neoplasms. Prolactinoma is the most common adult pituitary tumor accounting for 60% of functional pituitary adenomas [17]. Treatment is necessary in symptomatic patients and the primary therapeutic choice is medical therapy rather than surgery because the disease can be controlled, even cured with treatment of dopamine agonist in most cases [18, 19].
Increased survivin expression is shown in pituitary tumors but any study has not researched the survivin levels in plasma yet. In the current study, we aimed to determine serum survivin levels and evaluate its clinical significance at diagnosis of prolactinoma.
Materials and Methods ▴Top
Twenty-five female patients with prolactinoma with median age of 34 (17 - 51) years and 21 healthy female patients with a median age of 35 (22 - 45) years were included in the study. Patients were followed up at the Endocrinology outpatient clinic in the Ankara Training and Research Hospital. The patients were chosen among whose initial serum prolactin levels were > 250 ng/mL and the pituitary MRI showing adenoma [18]. Other functional pituitary tumors were excluded by dynamic hormone tests in all patients. The information of the tumor size was obtained from the last hypophysis MRI of patients. Twenty microprolactinoma patients and five macroprolactinoma patients were treated with appropriate doses of dopamine agonists. While 22 of them received cabergoline, three of them received bromocriptine. There was no tumor invasion to adjacent tissues in all patients. Having any other diseases (malignancy, diabetes mellitus, hypertension, hyperlipidemia, coronary artery disease, chronic liver or kidney diseases, gastrointestinal absorption problems, collagen tissue disease, and thyroid disease), and other functional or nonfunctional pituitary tumors were defined as exclusion criteria. All participants gave written informed consent and study was approved by local research ethics committee. The study was performed in accordance with Helsinki Declaration and Good Clinical Practice.
Body mass index (BMI) was calculated as the ratio of weight to the square of height (weight/heigh2 (kg/m2)).
Blood samples were collected after 12 h of fasting. Serum glucose, creatinine, alanine aminotransferase, thyroid stimulating hormone (TSH) and prolactin levels were measured. Biochemical parameters were studied using a Roche/Hitachi Modular autoanalyzer. In order to measure survivin levels, collected blood samples were centrifuged at 5,000 rpm/min after coagulation and stored at -80 °C until testing. Survivin was measured manually by EIA technique using Quantikine brand kits (Quantikine® Survivin Elisa kit, R&D Systems, Minneapolis, MN, USA).
All data were analyzed statistically using SPSS Statistics version 17 (IBM). Differences in numerical data between two groups were evaluated by Mann-Whitney U test. Correlation of survivin with other variables was analyzed by Spearman's rank test. Comparison of categorical variables was performed with Chi-square test and Fisher's exact test. A P value less than 0.05 was considered statistically significant.
Results ▴Top
A total of 25 patients and 21 healthy controls were enrolled in the study. All patients were female. Median age was 34 years in the patient group (range, 17 - 51 years), while 35 years in the control group (range, 22 - 45 years). The median BMI was 27.4 kg/m2 in the patient group (range, 17.7 - 37.4 kg/m2), and 25.7 kg/m2 in the control group (range, 16.2 - 47.2 kg/m2). There was no difference between the patients and controls in age, and BMI (P = 0.921, P = 0.400, respectively). Both groups showed no difference regarding serum glucose, creatinine, alanine aminotransferase, and TSH levels. Median, minimum and maximum biochemical levels of parameters and P values in the patients and controls are as follows (glucose 87 (range, 77 - 132) mg/dL, 90 (range, 77 - 107) mg/dL, P = 0.408; creatinine 0.82 (range, 0.67 - 1.01) mg/dL, 0.84 (range, 0.67-1.07) mg/dL, P = 0.748; alanine aminotransferase 27 (range, 18 - 51) U/L, 32 (22 - 49) U/L; P = 0.169; TSH 1.84 (range 0.35 - 3.72) mIU/L, 1.69 (range 0.35 - 4.68) mIU/L, P = 0.332; respectively). The median prolactin levels were significantly lower in prolactinoma patients than in healthy controls (5.09 (range, 0.24 - 12.00) ng/mL, 17.38 (range, 10.94 - 24.05) ng/mL, P < 0.001) (Table 1). Survivin levels were significantly higher in the patients compared to controls (19.04 (10 - 39) pg/mL, 15.05 (8 - 22), P = 0.042). Median tumor size was 5 mm, and minimum and maximum sizes ranged between 2 and 26 mm in the patient group. After subgroup analysis, median sizes of microadenomas and macroadenomas were 5 (range, 2 - 7) and 12 (range, 11 - 26) mm. There was no difference between microadenoma and macroadenoma patients in survivin levels (19.22 (range, 10 - 38) pg/mL, 18.40 (range, 16 - 22) pg/mL; P = 0.914).
Table 1. Baseline Clinical Features of Prolactinoma Patients and Healthy Controls
There was no correlation between survivin and other parameters in correlation analysis. Similarly, no correlation was found between tumor size and survivin levels (P = 0.565).
Pituitary tumors develop when the balance is disturbed between cell proliferation and cell death like other tumors. Activation of apoptosis suppressing signals has shown to be important in tumorigenesis and contributes to invasion and metastasis [18].
Survivin is undetectable in most adult tissues but its abundant expression was shown in most human tumoral cells [1, 6-16]. Retrospective clinical studies demonstrate that overexpression of survivin is correlated with increased proliferation, reduced apoptosis, and increased angiogenesis in colorectal cancer, whereas high levels of tumor survivin are associated with resistance to treatment and poor prognosis in multiple tumor types [20-25].
In addition to the studies demonstrating survivin expression in tissues, there are also some researches evaluating the serum levels of survivin in different cases [26-31]. Naumnik et al evaluated serum survivin, HMGB1, and VEGF in non-small cell lung cancer before and after four cycles of chemotherapy. Patients had higher HMGB1, VEGF levels while survivin levels were not different than healthy individuals. In conclusion, they pointed that HMGB1, VEGF, and survivin did not have any clinical significance in the prognosis of the survival time in lung cancer [30]. Goksel et al investigated the serum levels of her-2/neu and survivin in patients with early stage breast cancer. They found no difference in levels of serum her-2/neu and survivin between the breast cancer and the control group [26]. Bokarewa et al evaluated serum levels of survivin and antibodies against survivin in 131 rheumatoid arthritis patients. Results were related to joint erosivity at the time of sampling. Survivin levels were significantly higher in patients with destructive disease as compared with in RA patients displaying a non-erosive disease, whereas survivin antibodies led to a less aggressive course of the disease [31].
Survivin expression involving tissues of different pituitary adenomas was assessed in some studies. Most of the studies revealed higher survivin expression in pituitary tumors than in normal pituitary tissue [16, 32, 33]. Wasko et al investigated postoperative tissues of pituitary tumors of 43 patients and three normal pituitary tissues obtained at autopsy. Immunostaining was revealed nuclear localization of survivin in pituitary tumors as well as in normal pituitary tissue. Accumulation of survivin was less in normal pituitary than in tumoral tissues. Additionally, less intense immunohistochemical staining was observed in the cytoplasm of tumoral cells. They did not find any significant differences of accumulation between invasive and noninvasive tumors [16]. On the contrary, Zhang et al found significantly different expression rate in invasive and noninvasive tumors (89.7%, 40.7%, respectively) [32]. Jankowska et al found six-fold higher expression level of survivin expression in different pituitary tumors (acromegaly (n = 14), non-functioning pituitary tumor (n = 6), prolactinoma (n = 2) and corticotropinoma (n = 1)) than in normal pituitary tissue. It was not statistically significant difference between invasive and noninvasive tumors in terms of survivin level. Survivin was observed in the nuclei of pituitary tumors whereas it was restricted to small population of cells in normal pituitary tissue. They emphasized that overexpression of survivin is characteristic for pituitary tumors [33]. Contrary to the literature, Formasa et al did not find survivin expression in normal pituitary tissue in their study, including 47 pituitary adenomas (35 non-functioning, seven GH-secreting, three prolactinomas, and two ACTH-secreting tumors) and six normal controls [34]. Expression of survivin both in normal and neoplastic tissue suggests that the protein may play a regulative role in tissues during proliferation and it may also be a key factor in neoplastic formation of pituitary [1, 16, 23, 34, 35].
The primary therapeutic choice in prolactinoma is medical treatment with dopamine agonists that reduce the size of prolactinoma by inducing a reduction in cell volume, as well as causing perivascular fibrosis, partial cell necrosis, and reduce cellular DNA synthesis [36]. Moreover, dopamine induces apoptosis through the activation of terminal caspase, caspase-3 [37]. In the present study, the prolactin levels were significantly lower in patients with prolactinoma than healthy individuals because patients with prolactinoma were on dopamine agonist treatment. Although the effect of dopamine agonists on serum survivin levels is not known, it is impressive to find out statistically significant higher survivin levels in prolactinoma group than control. In this study, it is important that we showed persistently high levels of survivin in patients with prolactinoma despite normalized prolactin levels with medical treatment. In this respect, this is the first study evaluating serum survivin levels in prolactinoma patients under medical treatment. On the other hand, survivin was not correlated with prolactin levels and tumor size. In order to disclose any possible relationship, further prospective studies evaluating survivin and pituitary hormone levels and tumor size before and after treatment are required. By this way, possible relationship between pituitary tumors and survivin might be better clarified.
In conclusion, our data suggest that higher serum survivin levels might be a parameter for indicating prolactinoma. This study may guide to further researches.
There is no conflict of interest in our study.
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Ku JH, Kwak C, Lee HS, Park HK, Lee E, Lee SE. Expression of survivin, a novel inhibitor of apoptosis, in superficial transitional cell carcinoma of the bladder. J Urol. 2004;171(2 Pt 1):631-635.
Kim J, McNiff JM. Nuclear expression of survivin portends a poor prognosis in Merkel cell carcinoma. Mod Pathol. 2008;21(6):764-769.
Liu YB, Shen WG, Ge H, Gai XD, Lu LL, Zhao XJ. [Expressions of survivin and GRIM-19 in prostate cancer]. Zhonghua Nan Ke Xue. 2011;17(1):21-26.
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Vandghanooni S, Eskandani M, Montazeri V, Halimi M, Babaei E, Feizi MA. Survivin-deltaEx3: a novel biomarker for diagnosis of papillary thyroid carcinoma. J Cancer Res Ther. 2011;7(3):325-330.
Zahedi P, Aminimoghaddam S, Sayahpour FA, Haghpanah V, Amiri P, Fereidoni F, Mahrampour E, et al. Association of survivin gene polymorphism with endometrial cancer. Int J Gynecol Cancer. 2012;22(1):35-37.
Xue Y, An R, Zhang D, Zhao J, Wang X, Yang L, He D. Detection of survivin expression in cervical cancer cells using molecular beacon imaging: new strategy for the diagnosis of cervical cancer. Eur J Obstet Gynecol Reprod Biol. 2011;159(1):204-208.
Huang Y, Chen X, Chen N, Nie L, Xu M, Zhou Q. Expression and prognostic significance of survivin splice variants in diffusely infiltrating astrocytoma. J Clin Pathol. 2011;64(11):953-959.
Kayaselcuk F, Zorludemir S, Bal N, Erdogan B, Erdogan S, Erman T. The expression of survivin and Ki-67 in meningiomas: correlation with grade and clinical outcome. J Neurooncol. 2004;67(1-2):209-214.
Altieri DC. Survivin in apoptosis control and cell cycle regulation in cancer. Prog Cell Cycle Res. 2003;5:447-452.
Ikeguchi M, Ueda T, Sakatani T, Hirooka Y, Kaibara N. Expression of survivin messenger RNA correlates with poor prognosis in patients with hepatocellular carcinoma. Diagn Mol Pathol. 2002;11(1):33-40.
Erbayraktar Z, Aktas S, Altun Z, Olgun N. Role of Survivin in Determination of Chemoresistance in Neuroblastoma. Turkiye Klinikleri J Med Sci. 2011;31(5):1087-1093.
Wasko R, Waligorska-Stachura J, Jankowska A, Warchol JB, Liebert W, Sowinski J. Coexpression of survivin and PCNA in pituitary tumors and normal pituitary. Neuro Endocrinol Lett. 2009;30(4):477-481.
Gillam MP, Molitch ME, Lombardi G, Colao A. Advances in the treatment of prolactinomas. Endocr Rev. 2006;27(5):485-534.
Arafah BM, Nasrallah MP. Pituitary tumors: pathophysiology, clinical manifestations and management. Endocr Relat Cancer. 2001;8(4):287-305.
Melmed S, Casanueva FF, Hoffman AR, Kleinberg DL, Montori VM, Schlechte JA, Wass JA. Diagnosis and treatment of hyperprolactinemia: an Endocrine Society clinical practice guideline. J Clin Endocrinol Metab. 2011;96(2):273-288.
Kawasaki H, Altieri DC, Lu CD, Toyoda M, Tenjo T, Tanigawa N. Inhibition of apoptosis by survivin predicts shorter survival rates in colorectal cancer. Cancer Res. 1998;58(22):5071-5074.
Monzo M, Rosell R, Felip E, Astudillo J, Sanchez JJ, Maestre J, Martin C, et al. A novel anti-apoptosis gene: Re-expression of survivin messenger RNA as a prognosis marker in non-small-cell lung cancers. J Clin Oncol. 1999;17:2100-2104.
Tanaka K, Iwamoto S, Gon G, Nohara T, Iwamoto M, Tanigawa N. Expression of survivin and its relationship to loss of apoptosis in breast carcinomas. Clin Cancer Res. 2000;6(1):127-134.
Shinohara ET, Gonzalez A, Massion PP, Chen H, Li M, Freyer AS, Olson SJ, et al. Nuclear survivin predicts recurrence and poor survival in patients with resected nonsmall cell lung carcinoma. Cancer. 2005;103(8):1685-1692.
Islam A, Kageyama H, Takada N, Kawamoto T, Takayasu H, Isogai E, Ohira M, et al. High expression of Survivin, mapped to 17q25, is significantly associated with poor prognostic factors and promotes cell survival in human neuroblastoma. Oncogene. 2000;19(5):617-623.
Kato J, Kuwabara Y, Mitani M, Shinoda N, Sato A, Toyama T, Mitsui A, et al. Expression of survivin in esophageal cancer: correlation with the prognosis and response to chemotherapy. Int J Cancer. 2001;95(2):92-95.
Goksel G, Taneli F, Uslu R, Ulman C, Dinc G, Coskun T, Kandiloglu AR. Serum her-2/neu and survivin levels and their relationship to histological parameters in early-stage breast cancer. J Int Med Res. 2007;35(2):165-172.
Guney N, Soydine HO, Derin D, Tas F, Camlica H, Duranyildiz D, Yasasever V, et al. Serum and urine survivin levels in breast cancer. Med Oncol. 2006;23(3):335-339.
Derin D, Soydinc HO, Guney N, Tas F, Camlica H, Duranyildiz D, Yasasever V, et al. Serum levels of apoptosis biomarkers, survivin and TNF-alpha in nonsmall cell lung cancer. Lung Cancer. 2008;59(2):240-245.
Tas F, Duranyildiz D, Argon A, Oguz H, Camlica H, Yasasever V, Topuz E. Serum bcl-2 and survivin levels in melanoma. Melanoma Res. 2004;14(6):543-546.
Naumnik W, Nilklinska W, Ossolinska M, Chyczewska E. Serum levels of HMGB1, survivin, and VEGF in patients with advanced non-small cell lung cancer during chemotherapy. Folia Histochem Cytobiol. 2009;47(4):703-709.
Bokarewa M, Lindblad S, Bokarew D, Tarkowski A. Balance between survivin, a key member of the apoptosis inhibitor family, and its specific antibodies determines erosivity in rheumatoid arthritis. Arthritis Res Ther. 2005;7(2):349-358.
Zhang YC, Gao J, Xin T, Zheng ZM, Teng LZ. Expression of survivin in invasive pituitary adenoma. Saudi Med J. 2008;29(11):1589-1592.
Jankowska A, Wasko R, Waligorska-Stachura J, Andrusiewicz M, Jaskula M, Liebert W, Sowinski J. Survivin products in pituitary tumors. Neuro Endocrinol Lett. 2008;29(6):1033-1037.
Formosa R, Gruppetta M, Falzon S, Santillo G, DeGaetano J, Xuereb-Anastasi A, Vassallo J. Expression and clinical significance of Wnt players and survivin in pituitary tumours. Endocr Pathol. 2012;23(2):123-131.
Hassounah M, Lach B, Allam A, Al-Khalaf H, Siddiqui Y, Pangue-Cruz N, Al-Omeir A, et al. Benign tumors from the human nervous system express high levels of survivin and are resistant to spontaneous and radiation-induced apoptosis. J Neurooncol. 2005;72(3):203-208.
Colao A, di Sarno A, Pivonello R, di Somma C, Lombardi G. Dopamine receptor agonists for treating prolactinomas. Expert Opin Investig Drugs. 2002;11(6):787-800.
Rowther FB, Richardson A, Clayton RN, Farrell WE. Bromocriptine and dopamine mediate independent and synergistic apoptotic pathways in pituitary cells. Neuroendocrinology. 2010;91(3):256-267.
This is an open-access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited.
Journal of Clinical Medicine Research is published by Elmer Press Inc.


This client is known as Trixie, she is a miniature mare.
She suffers from allergies to mosquito bites, which manifest as open lesions on her skin. She also had some areas of rain scald, a condition where the hair falls out, and the skin is bare.
These itch constantly, and cause her great distress, as she constantly scratches them.
I applied Blue Mink in a spray to the affected areas. This was intended to soothe the area, and ease the itching. The spray was used twice a day, and because it was applied to the lesions topically, she had to have several areas sprayed each time.
The effect was immediate. She stopped scratching, and the sores, that had been open and sensitive to touch became dry, and within a week the hair began to regrow.
Trixie is now happier than before the treatment, and instead of scratching on the trees, she spends her time catching up on some serious eating.
She also now wants the spray, instead of walking away when I approach her with it.


Toho's™ beads are favored for their high quality, precision crafting, and uniformity in size. Bugle beads are cylindrical, slender tubes of glass with a hole going through the middle of the bead. Their tube-like shape, smooth holes and clean-cut ends make them ideal for a variety of beading designs. They work well as spacers, and can also be used for stinging, weaving and bead embroidery.
These are 3mm (size #1) Bugle beads.
Measurements: 3mm long. Threading hole size of 1mm.


American and British pop music have a lot in common besides a language. There are some styles, notably straight-ahead rock and roll where it's hard to tell from which side of the Atlantic the artist hails. Other genres can have a distinctly American or British flavor. There are endless numbers of trendy British pop styles going back to the Beatles, and over the decades also including varieties like art-rock and peculiarly British dance crazes. Although it can be argued that the British got all their rock & roll influences from the US in the first place, there are some styles which have remained distinctly American, such as R&B and the folk-based singer-songwriter genre. The English have tried both, but the results come out with a distinctly UK accent. As far as folkies go, the Brits developed a unique style back in the late 1960s through groups like Fairport Convention, that continues to this day.
This week's album is by a British folkie who has developed a very American style and sound. He is John Wesley Harding, and his latest recording is entitled John Wesley Harding's New Deal.
Wesley Harding Stace assumed the name of the famous American outlaw immortalized in Bob Dylan's song when he began performing. Interestingly one of his early influences was another British Isles performer with an American sound, Elvis Costello, and early in Harding's career, many observed the similarity between his and Costello's vocal sounds. Also inviting comparison was the presence of two of Costello's band members on two of Harding's albums. Despite Costello's shadow, Harding began to distinguish himself in the late 1980s with a somewhat folkier sound and lyrics that occasionally tended toward the more political, also in the American folkie tradition.
Since then, Harding has been developing a reputation for his insightful songs that are full of great wordcraft and attractive pop melodies.
Now as he is approaching his thirtieth birthday, Harding has come to America for his new album, and ends up sounding even more like a folksinger from this side of the Atlantic. There's a mainly acoustic backing, largely absent drums, and full of the kind of articulate and introspective lyrics that singer-songwriters from Jackson Browne to John Gorka have made their stock-in-trade. On the other hand, this album is rather less political than some of Harding's more recent works, such as his outstanding 1993 release Why We Fight. There are a few love songs, but much of this album consists of little vignettes about characters, in varying degrees of haplessness.
New Deal was recorded in the San Francisco Bay area, and was co-produced by Chris von Snidern, who himself is an adroit singer-songwriter with a pop disposition. It's a generous collection of thirteen compositions that run from personal relationships with a twist to songs that do attempt to take on the state of the world. The accompaniment is exceptionally tasteful and understated. There is occasionally a drummer heard, but the rockiest tunes often lack percussion and convey their musical energy because of the song itself and the presence of some electric guitar. But just as often you'll hear a cello or violin, or a little steel guitar adding a hint of country. One can also occasionally hear a little Beatles influence in some of the arrangements.
The new release entitled John Wesley Harding's New Deal is another outstanding recording from the British-born singer-songwriter whose voice sounds a bit like Elvis Costello, and who occasionally borrows bits of Beatles influence in his musical arrangements, but who is sounding more and more like an American folk-style singer-songwriter. New Deal continues Harding's tradition of exceptionally fine lyric writing, both in terms of the way he puts words together, and the way he treats his subjects, which he can often turn into telling observations about the world in general. He is an appealing vocalist and this album features a scaled-back, mostly acoustic instrumental setting that contrasts with his previous, more electric work. He is also a bit less political this time around. The result makes for exceptionally fine listening. One thing I miss is a printed lyric sheet in the CD booklet, but Harding is quite intelligible, and repeated listenings to his music will engender a greater appreciation for his wordcraft.
From a technical standpoint, the album is competently done with a clean mix, unencumbered by excessive studio effects. The sound, like the album's contents is fairly understated, and comes to be appreciated more with time.
John Wesley Harding is one of the best singer-songwriters to come out of England in the past several years, and his New Deal, with its American recording venue and musical style, underscores that position. After several releases for major labels, now Harding has gone the independent route at least here in America, perhaps explaining this album's lack of commercial concessions. It is one of the finest recordings from a performer who continues to win more fans, but still, I think, deserves wider recognition.


text:
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  DISCOUNT_ON_STRAWBERRIES = 4.5
  before do
    @pricing_rules = [{code:"FR1", name:"Fruit tea", price:3.11, offer:"Buy one get one free"},
    {code:"SR1", name:"Strawberries", price:5.00, offer:"Buy 3 or more strawberries and price drop to £ #{DISCOUNT_ON_STRAWBERRIES} on each"},
    {code:"CF1", name:"Coffee", price:11.23, offers:""}]
  end

  describe "initialize" do
    it "should initialize an object" do
      obj = Checkout.new @pricing_rules
      @pricing_rules.should == obj.products
      @pricing_rules[0][:code].should == obj.products[0][:code]
      @pricing_rules[0][:price].should == obj.products[0][:price]
      obj.items.should == []
      obj.quantity.should == {}
    end
  end

  describe "display_products" do
    it "should display products list" do
      obj = Checkout.new @pricing_rules
      obj.should_receive(:puts).with("Product code \t Name \t\t Price \t\t Offer")
      obj.should_receive(:puts).with("-" * 60)
      @pricing_rules.each do |product|
        obj.should_receive(:puts).with("#{product[:code]} \t\t #{product[:name]} \t £ #{product[:price]} \t #{product[:offer]}")
      end
      obj.should_receive(:select_menu_product).and_return(true)
      obj.display_products
    end
  end

  describe "select_product" do
    it "should add products to basket" do
      count_quantity = {}
      obj = Checkout.new @pricing_rules
      code = ["FR1", "SR1", "CF1"]
      obj.should_receive(:print).with("Enter the quantity for FR1 :")
      quantity = 2
      stub!(:gets).and_return(quantity)
      obj.items << "FR1"
      obj.quantity["FR1"] = 2
      obj.should_receive(:puts).with("Added to Basket: FR1")
      obj.should_receive(:select_menu_product).and_return(true)
      obj.select_product("FR1")
    end

    it "should display error message if entry is invalid" do
      obj = Checkout.new @pricing_rules
      obj.should_receive(:puts).with("Invalid product code")
      obj.should_receive(:select_menu_product).and_return(true)
      obj.select_product("FR1123")
    end

  end

  describe "select_menu_product" do
    it "should select the entry to display menu or entry product code or checkout" do
      obj = Checkout.new @pricing_rules
      obj.should_receive(:print).with('For Menu press "M" or Enter "product code" for selecting item or press "C" for checkout:')
      product_menu = "m"
      stub!(:gets).and_return(product_menu)
      obj.should_receive(:check_product).and_return(true)
      obj.select_menu_product
    end
  end

end

redpajama_set_name: RedPajamaGithub


text:
Advanced Strategic Planning for Life Science, Medtech Startups
February 15, 2022 | 7:00 pm - 8:30 pm ET | Free Webinar
Speaker Slides
Advanced Strategic Planning for Life Science & Medtech Startups
Vicki Anastasi, Medical Device Executive & Strategic Advisor; Jo Ellen Slurzberg, VP Global Health Policy and Reimbursement, JR Associates; Christopher L. Waller, Ph. D., Vice President and Chief Scientist EPAM Systems, Inc.; Jeff Antos, Vice President, Regulatory Sciences at ProPharma Group
Launching a new entrepreneurial venture is hard work, requiring inspiration, initiative, and lots of perspiration. In a life sciences startup, as if finding Co-Founders, financing, facilities, business partners, and carrying out complex scientific research weren't enough, there are stringent regulatory compliance and reimbursement issues that need to be met. Any product or service that provides treatment or diagnostics for humans will need regulatory approval, a decidedly non-trivial exercise. Importantly, at least in the United States, regulatory approval has no bearing on whether third-party payers (e.g., healthcare insurance) will pay the cost for patients. Whether a life science entrepreneur plans to go to market alone, or with product development partners, success requires an understanding of the process and an execution strategy that addresses appropriate R&D quality, with rigorous, validated data handling and analytics capabilities to provide critically important information to regulators and reimbursement specialists.
Tonight's panelists will offer up insights to help life science entrepreneurs to plan for success.
(all times are USA Eastern Standard time)
ENET Chairperson's announcements
eMinute Pitch
Up to 3 Startup pitches
4 expert speakers on the night's topic
Moderator and Audience Q & A with the speakers
Panelists will be available afterward for responses to individual questions.
Vicki Anastasi
Medical Device Executive & Strategic Advisor
Vicki Anastasi has over 30 years of experience in the medical device industry, with over 20 years specifically focused on global medical device and diagnostic strategic consulting. She has held senior management roles for medical device and therapeutic companies focused in orthopedics, cardiovascular/metabolic disease and combination products. In diagnostics, she held senior positions at companies involved in the development of infectious disease and genetic-based products including companion diagnostics and precision medicine.
Her most recent role was as SVP Clinical, Regulatory and Quality at Farcast Biosciences formerly Mitra Biotech, a cancer diagnostic research company focused on fast track drug discovery using a human tumor histoculture platform. Previously she was at CRO where she served as Global Head for ICON's Medical Device and Diagnostics Research business unit.
Vicki guides pharmaceutical, biotechnology and medical device companies in developing and implementing roadmaps for demonstrating drug and device value, safety and effectiveness by leading innovative approaches including RWE initiatives, Ph IIIb/IV, pilot/pivotal studies and HEOR evaluations across the globe to optimize market access.
Vicki is actively involved in industry groups, where she regularly speaks and participates in focused panels and discussions.
Jo Ellen Slurzberg
VP Global Health Policy and Reimbursement, JR Associates.
Jo Ellen Slurzberg leverages decades of reimbursement and health policy experience as VP for JR Associates, a boutique life sciences reimbursement and market access consultancy. She is an industry veteran having served in senior reimbursement management roles at multiple companies, securing coverage, coding and payment for a spectrum of innovative biomedical, pharmaceutical and medical device technologies used in the U.S. and abroad. Her perspective comes from extensive experience driving reimbursement for small startup companies and established global conglomerates.
Jo Ellen is a speaker on health policy trends and reimbursement‐related business issues and has written numerous reimbursement‐ related articles, is a contributing author and collaborator on Harvard Business School Notes with Professor Regina Herzlinger for whom she is a research associate. She serves as a mentor to Harvard Business School/Harvard School of Public Health, and as an advisor to the Harvard Innovation Lab (I‐Lab), and other translational medicine programs. Jo Ellen has participated in the Global Educators Network for Health Innovation Education (GENiE), a consortium of health innovation business school leaders from around the world. She is an active member of the Medical Device Manufacturers Association (MDMA), previously serving on its board and chairing a Reimbursement Task Force.
Christoper L. Waller, Ph. D.
Vice President and Chief Scientist EPAM Systems, Inc.
Dr. Waller is currently Vice President and Chief Scientist of the Life Sciences business unit at EPAM Systems, Inc. where his focus is on using data and analytics to transform pharmaceutical research and development.
Dr. Waller received his Ph.D. in Medicinal Chemistry and Natural Products from the University of North Carolina in Chapel Hill in 1992. Following graduation, Dr. Waller accepted a post-doctoral fellowship under the direction of Dr. Garland Marshall at Washington University in St. Louis where he focused his efforts on the design HIV protease inhibitors. In 1993, Dr. Waller accepted a position with the U.S. EPA in which he was responsible for the development of structure-activity relationship and pharmacokinetic models as a research chemist and leader of a team of analytical, computational, and synthetic organic chemists, toxicologists, and biomedical engineers. From 1996-1999, Dr. Waller served as a Research Manager at OSI Pharmaceuticals. In this role, he managed a group of computational chemists, scientific application developers, and robotics engineers. In early 1999, Dr. Waller joined Eli Lilly- Sphinx Laboratories as a computational chemist and Head of Cheminformatics in the Discovery Chemistry group. Between 2001 and 2012, Dr. Waller held a number of positions in the research and informatics divisions at Pfizer, Inc. From 2012-2017, Dr. Waller held a number of positions at Merck & Co. initially as Head of Cheminformatics and culminating in the role of Executive Director of Predictive Modeling Platforms and Data Science.
Dr. Waller is on faculty at Northeastern University where he lectures on leadership and analytics, holds an Adjunct Professor position at the University of North Carolina at Chapel Hill, is an Advisory Board member and benefactor of the Hurt Hub at Davidson College, a center dedicated to data science and innovation, and is a founding Board Member of the Pistoia Alliance, a not-for-profit organization focusing on pre-competitive collaborations in pharmaceutical research information technology.
Matthew Weinberg
President, Regulatory Sciences at ProPharma Group
Matthew Weinberg is responsible for the global Regulatory Sciences group at ProPharma Group. As the world's leading pharma and med device consultancy, we offer our clients the ability to move through the regulatory hurdles they face when developing new products and maintaining their market status once approved. With our reliance and decades of history of providing excellence, we have assisted in the approval of hundreds of new drugs, biologics and medical devices.
In addition, Mr. Weinberg plays an active role in the community as Chair Emeritus of Building Steps, a Baltimore-based nonprofit that helps minority and underprivileged high school students pursue careers in the fields of science and technology. Building STEPS was founded by Matthew Weinberg as an internship program in 1995. In its early years, Building STEPS had no more than 20 students in its cohorts. Today, the organization serves more than 130 Baltimore city public high school juniors and seniors, as well as 250 college students and alumni each year. Mr. Weinberg is also involved in the Jewish Community of Washington DC.
Moderator & Organizers
Kristin King, MBA.
Boston Harbor Angel Investor; VP, Corporate Development, Defibtech
Kristin is an accomplished MedTech executive, serial intrapreneur, investor and strategic advisor to startups developing biotech solutions. With over 20 years spanning technical, marketing, and proud member of Boston Harbor Angels, she offers multi-discipline expertise transforming technologies from early concept to successful global divisions at leading Medical Device companies and startups.
Roger Frechette
Principal and Founder of NEPAssociates, LLC
Roger is a life sciences consultant/advisor, helping clients by leveraging an extensive global network and multi-disciplinary insights derived from >20 years of experience in the business of life sciences, calibrated with an extensive science background. His career has encompassed success as a business executive, project/alliance manager and entrepreneur, and as a scientist, including leadership of discovery/preclinical development teams resulting in two FDA approved therapeutics. Roger has been a volunteer with Boston ENET since 2014, in addition to supporting start-ups as a mentor with MassBio, and other Greater Boston Area entrepreneur support groups. He also a mentor with 12Ronnies, a global early-stage startup mentorship organization.
February 15, 7 – 8:30pm EST
This event is FREE, however, registration is required.
Event has ended.


text:
package main

import "fmt"
import "os"
import "os/signal"
import "os/exec"
import "path/filepath"
import "syscall"

import reaper "github.com/ramr/go-reaper"

const NWORKERS=3

func start_workers() {
	//  Starts up workers - which in turn start up kids that get
	//  "orphaned".
	dir, err := filepath.Abs(filepath.Dir(os.Args[0]))
	if err != nil {
		fmt.Printf(" - Error getting script dir - %s\n", err)
		return
	}

	var scriptFile = fmt.Sprintf("%s/bin/script.sh", dir)
	script, err := filepath.Abs(scriptFile)
	if err != nil {
		fmt.Printf(" - Error getting script - %s\n", scriptFile)
		return
	}

	var args = fmt.Sprintf("%d", NWORKERS)
	var cmd = exec.Command(script, args)
	cmd.Start()

	fmt.Printf("  - Started worker: %s %s\n", script, args)

}  /*  End of function  start_workers.  */

func main() {
  sig := make(chan os.Signal, 1)
  signal.Notify(sig, syscall.SIGUSR1)

  /*  Start the grim reaper ... */
  go reaper.Reap()

  /*  Start the initial set of workers ... */
  start_workers()

  for {
    select {
    case <-sig:
	fmt.Println("  - Got SIGUSR1, starting more workers ...")
	start_workers()
    }

  }  /*  End of while doomsday ... */

}  /*  End of function  main.  */


Larry King - what next for the king of chat shows?
Veteran US broadcaster Larry King has presented the final edition of his long-running CNN talk show after 25 years with the cable news channel. King fought back tears as he told his audience: "Thank you, and instead of Goodbye, how about So Long?" King has been an icon in US television for decades, and even President Obama paid tribute to the star, saying that King`s show had "opened our eyes to the world beyond our living rooms". Larry King Live ended after a run of over 6,000 shows and 50,000 interviews, and there are few people in the world that can say that they have spoken to 50,000 people in their lives. So what next for this legendary man?
Larry King was born on November 19th 1933, making him a Scorpio born in the Chinese year of the Rooster. Scorpios are notorious for speaking their mind and nobody could ever accuse King of holding back his opinions. The flamboyancy of his Rooster personality has kept him in the limelight and would explain his enduring reputation and formidable presence for over 25 years on US television screens. This is a Rooster that has definitely been king of the yard for many years, and as such replacement Piers Morgan has some very big shoes to fill. But after so many years in the limelight, it is his retrospective Scorpio nature that has called time on his public career and King is now set for a more relaxing time with a Scorpio`s first love - his family. However, that Rooster personality will still crave a little bit of attention occasionally and King has already said that he will be doing a few special appearances in the future. So it seems that the world has not seen the last of one of the true heavyweights of broadcasting.


SKU: AF1603. Category: AMF Bowling Balls.
It's back and you never even saw it coming!
The Ninja SE is back with a vengeance, and ready to inflict damage on whatever stands in its way. The second introduction into the AMF Vintage line the Ninja SE is going to provide a stronger motion at the breakpoint with more continuation when compared to the Night Hawk SE. The Ninja SE F70 coverstock finished with the NEAT "T" 4,000 grit finish will handle higher volumes of oil than the Night Hawk SE. The Ninja SE fits into the AMF lineup between Night Hawk SE and Escape, by providing more entry angle, with more overall hook than the Night Hawk SE and less than the Escape.


Mug Shot Monday — Nik Patel's Two-Year old Quotes Hint at Fraud?
All are quotes from Nik Patel in a profile by Hotel News Now published two years ago.
Nik Patel is the sole figure accused of an $180 million fraud of selling bogus USDA business & industry loans to Pennant Management. The investment firm closed its doors last week.
The purpose of my fraud coverage is to educate small business lenders of the warning signs of fraud.
One of the warning signs I see is a fraudster thinks they are the smartest person in the room.
That attribute doesn't automatically equate with being a crook, it is simply a warning sign that should be be explored.
And I believe this attitude is apparent from the article. Patel's plan was to buy hotel properties no one else would touch. He was the only one to have the "vision" and smarts to know which hotels to purchase and renovate throughout the country.
"No one wanted the (University of Central Florida) Holiday Inn for a long time, but we had a vision. We saw where the market was going, and we acted on that," he said.


Plastic Chair Feet Square Tubing 7/8" O.D. X 13/16" I.D.
Plastic Chair Tips Square Tubing for 7/8" Outside Diameter X 13/16" Inside Diameter. Fits square tubing legs with an outside diameter of 7/8" and an inside diameter of 13/16". Available in black.


text:
India played with heart and desire in 3rd ODI, lesson to take forward in Australia: Virat Kohli
Virat Kohli said India were determined to come up with a spirited effort in the ODI series finale in Canberra against Australia and the skipper was elated, saying the team did show a lot of "heart and desire" during their 13-run win on Wednesday.
India avoided a 3-0 clean sweep in the ODI series by winning the 3rd ODI by 13 runs at the Manuka Oval. Helped by Hardik Pandya and Ravindra Jadeja's record-breaking 150-run stand and a much-improved bowling show, India managed to clinch an inconsequential yet important win as they can take the confidence into the T20I and Test series.
Virat Kohli pointed out that India played with a lot more intensity and it's an important lesson, saying they need to be switched on from the word go when playing in demanding conditions in Australia.
3rd ODI: Highlights | Report
"Even though we lost the series, I think this third game was important for us as a side to understand that we should play with heart and play with desire and then good things follow. This is a lesson we should take forward especially when things can be very intense if you are not on the ball and I have experienced that a few times before," Virat Kohli said.
Virat Kohli led from the front with the bat after a disappointing start to the innings in Canberra as Shikhar Dhawan threw it away as early as the 6th over. Young Shubman Gill showed flashes of brilliance but he failed to convert his start into a big innings.
Kohli though kept the scoreboard moving with a fine display of stroke-making during which he also broke Sachin Tendulkar's record for the fastest batsman to 12,000 ODI runs. After losing partners at regular intervals, Kohli himself departed in the 32nd over for 63.
Just when it looked like India would struggle to get to 250-260, Ravindra Jadeja and Hardik Pandya paced their partnership to perfection. The duo went hammer and tongs in the last few overs as India finished with a par total of 302.
Hardik Pandya showcased once again he could be a pure batsman at No. 6 as he hit the 2nd ninety of the series while Ravindra Jadeja chipped in with a 50-ball 66 not out.
Kohli heaped rich praise on the duo, saying it provided the much-needed boost to the score after his wicket.
"I would have liked to go on for a bit longer, but we had a great partnership between Hardik and Jadeja. It was exactly what the team needed to get that boost," Kohli said.
"It's particularly pleasing that we were under the pump for the first half of our innings, and second half of Australia's, and we fought back both times."
India will look to seal an early lead when they return to Canberra on Friday for the T20I series opener.
Legal notice sent to actress Kangana Ranaut for tweeting fake news on Shaheen Bagh dadi : Bollywood News – Bollywood Hungama
India vs Australia, 3rd ODI: Been working really hard to make sure I play for my country, says Hardik Pandya
ESL confirm new plans, eyes 80-club tournament
1st Test, Day 1: Ravindra Jadeja Marks International Comeback With A Five-Wicket Haul As India Dominate Australia | Cricket News
Russians would win 'medals of blood,' Usyk says
Must Bring Curtain Down On Issues Concerning All India Football Federation: Supreme Court | Football News


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