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Ceuta  (prononcé en espagnol , du latin Septem Fratres ; Abyla dans l'Antiquité ou Sebta ⵙⴱⵜⴰ en berbère et سبتة en arabe) est une ville autonome espagnole sur la côte nord de l'Afrique ayant une frontière directe avec le Maroc.

L'enclave espagnole est, comme sa voisine Melilla, située sur le continent africain, en face de la péninsule Ibérique, à environ quinze kilomètres des côtes de la province espagnole de Cadix. Ces deux enclaves sont les seuls passages terrestres qui relient l'Union européenne à l'Afrique. Ceuta est sous souveraineté espagnole (Plazas de soberanía) mais revendiquée par le Maroc depuis 1956.

Géographie

Ceuta, d'une superficie de , est constituée en grande partie par le territoire continental, terminé par la péninsule d'Almina, dominé par Monte Hacho, et au bout de laquelle se trouve la Punta Almina. La forme incurvée de la péninsule a permis, grâce à d'importants travaux d'aménagement - longues digues, terre-pleins gagnés sur la mer, quais... - la création d'un appareil portuaire de qualité.

Ceuta est situé sur le passage stratégique que constitue le détroit de Gibraltar, à environ  de Gibraltar. En raison de sa proximité avec les côtes espagnoles, il est possible d'apercevoir les maisons de Ceuta depuis Algésiras.

Côté terre, la frontière entre l'enclave et le Maroc est matérialisée par un dispositif frontalier renforcé (mur, capteurs de mouvement, caméras, route de patrouille...). Au total, un millier d'hommes, pour les deux tiers issus de la Guardia Civil espagnole, y sont présents en permanence.

Climat

Histoire

Fondée par les Phéniciens, au , la ville est riche d'une histoire culturelle féconde et originale du fait de sa position stratégique et différente à son tour de la culture environnante de l'Afrique du Nord, amazigh, maure puis arabe. Conquise par les Grecs phocéens et nommée « Hepta Adelphoi », elle devient carthaginoise . Après la victoire de Rome sur Carthage, les Numides occupent la ville jusqu'au règne de l'empereur Caligula, qui l'intègre à l'Empire dans l'année 40.

La Septa romaine, chrétienne et latine, dure jusqu'à la conquête musulmane, en 709, avec des parenthèses de domination vandale et byzantine. Elle appartient à la Maurétanie tingitane et en devient un centre commercial de premier ordre, profitant de sa situation de carrefour méditerranéen.

Les alternances dans la domination sur la ville se reflètent dans la culture prédominante à chaque époque. Sept siècles de domination musulmane effacent presque entièrement les vestiges romains et chrétiens de la ville.

Période préromaine
  : la ville est sous contrôle phénicien puis phocéen, et désignée sous le nom d'Hepta Adelphoi.
 319  : la ville est conquise par Carthage.
 201  : Carthage perd la guerre contre Rome et la ville passe sous contrôle du royaume berbère des Numides.
 47  : Ceuta passe sous contrôle du royaume berbère de la Maurétanie.

Domination romaine et post-romaine (40-709)
 40 : la ville est prise par les Romains sous le règne de l'empereur Caligula et est intégrée à la province romaine de la Maurétanie tingitane.
 296 : la Maurétanie tingitane est incorporée au diocèse d'Hispania.
 429 : les Vandales franchissent le détroit de Gibraltar entre Tanger et Ceuta, et se dirigent vers l'est en direction de Carthage.
 534 : Ceuta, ainsi que le reste de l'ancienne province de Maurétanie Tingitane, est prise par le général byzantin Bélisaire qui agit sous les ordres de l'empereur Justinien. Les provinces de Bétique et Maurétanie tingitane sont unies par les Byzantins pour former l'Exarchat de Carthage.
 624 : Ceuta passe aux mains du royaume wisigoth ibérique.

Domination musulmane (709-1415)
 709 : Ceuta est livrée aux Omeyyades par le comte Julien, le gouverneur local de la ville et vassal des Wisigoths de la péninsule Ibérique. Il semblerait qu'il ait trahi Roderic à la mort de Wittiza en 711, au profit du prince d'Agila, en favorisant le passage des troupes musulmanes.
 740 : soulèvement berbère dans l'actuel nord du Maroc contre le pouvoir arabe ; les Omeyyades sont massacrés.
 789 : la ville est prise par la dynastie des Idrissides (fondateurs de l'État marocain ).
 931 : la ville, ainsi qu'une partie du nord du Maroc, est prise par le califat de Cordoue sous Abd al-Rahman III. À l'instar du reste du califat de Cordoue, Ceuta entre dans une période de déclin.
 1061 : Suqut al-Bargawati, wali de Tanger et Ceuta, se proclame indépendant.
 1084 : la dynastie des Almoravides s'établit comme le nouveau pouvoir dans la région. Youssef ben Tachfine, premier souverain almoravide et sultan de Marrakech, prend la ville de Ceuta, puis après plusieurs années entreprend la conquête de tous les taïfas d'al-Andalus, repoussant les royaumes chrétiens vers le nord de la péninsule Ibérique.
 1147 : Ceuta est prise par le sultan almohade du Maroc qui conquiert tout le Maghreb et la moitié sud de la Péninsule ibérique.
 1212 : défaite de l'empire des Almohades à la bataille de Las Navas de Tolosa : les Almohades cèdent leurs territoires ibériques aux Andalous, reconstitution des taïfas. Ceuta reste sous domination du sultan de Marrakech.
 1232 : prise éphémère de la ville par la taïfa de Murcie.
 1233 : ville indépendante.
 1236 : la ville est prise par la dynastie des Mérinides, nouvelle dynastie zeneta-musulmane ayant Fès comme capitale.
 1242 : la ville passe sous le contrôle éphémère de la dynastie des Hafsides de Tunis.
 1249 : la famille locale azafide expulse les Hafsides, prend le pouvoir à Ceuta et fait allégeance au sultan de Fès.
 1291 : signature du traité de Monteagudo entre les royaumes de Castille et d'Aragon. Les deux royaumes se partagent les zones d'influence sur la Méditerranée : dans le traité Ceuta reviendrait à la Castille.
 1305 : la ville est prise par le royaume nasride de Grenade.
 1309 : la ville est reprise par le sultan de Fès avec l'aide du royaume d'Aragon : les Azafides sont de nouveau nommés walis de Ceuta par le sultan marocain.
 1340 : le sultan marocain Abou el-Hassan ben Othman débarque à Ceuta après la défaite de ses troupes à la bataille du Salado qui signe la fin des interventions marocaines dans la Péninsule ibérique.
 1384 : le royaume nasride de Grenade prend Ceuta.
 1387 : Ceuta est reprise par les Mérinides de Fez.

Domination portugaise et espagnole

 1415 : le Portugal prend Ceuta à la dynastie mérinide et entame ainsi une vaste campagne d'expéditions coloniales en Afrique : Bataille de Ceuta (1415).
 1437 : échec d'une expédition portugaise menée par Henri le Navigateur contre Tanger. Une partie du corps expéditionnaire est fait prisonnier et l'infant Ferdinand est gardé en otage. Un traité est signé par lequel les Portugais obtiennent de pouvoir partir à condition de rendre Ceuta et de laisser l'infant en otage, pour garantir l'exécution de ce pacte ; mais l'infant meurt en captivité et le pacte n'est pas respecté.
 1469 : naissance de l'Espagne moderne à partir de l'union dynastique des Couronnes de Castille et d'Aragon.
 1479 : le Portugal et la Castille signent le traité d'Alcáçovas par lequel les deux royaumes se partagent les zones d'influence sur le Maroc, alors sous domination wattasside ; la Castille y reconnaît Ceuta comme possession portugaise et confirme n'avoir aucun droit historique sur la ville.
 1494 : traité de Tordesillas entre le Portugal et l'Espagne ; cette dernière reconnaît de nouveau Ceuta comme possession portugaise.
 1509 : l'Espagne et le Portugal signent la capitulation de Cintra dans laquelle l'Espagne reconnaît n'avoir aucun droit sur les colonies portugaises dans la côte marocaine allant de Ceuta à Boujdour.
 1578 : mort du roi portugais , en 1578 à la bataille des Trois Rois, sans héritier.
 1580 : l'Espagne remporte la bataille d'Alcántara. Philippe II d'Espagne est proclamé roi de Portugal (Philippe ), les possessions et colonies portugaises sont incorporées au royaume d'Espagne.
 1640 : le Portugal recouvre son indépendance mais Ceuta, peuplée par une majorité d'origine espagnole, reste sous la souveraineté espagnole.
 1668 : le traité de Lisbonne entre le Portugal et l'Espagne garantit la séparation entre les deux pays, mais au prix de la reconnaissance officielle de l'appartenance de Ceuta à l'Espagne.
 1694-1724 : le sultan Ismaïl ben Chérif, de la dynastie alaouite, prend plusieurs villes portugaises et espagnoles sur la côte atlantique de l'actuel Maroc, puis mène un long siège devant Ceuta qui se solde par un échec dû au ravitaillement de la ville par voie de mer depuis la péninsule Ibérique.
 1702 : la ville est attaquée par l'Angleterre ; Ceuta résiste mais Gibraltar est conquise en 1704. L'Espagne reconnaît la souveraineté britannique sur ce dernier territoire par le second traité d'Utrecht (1713) avec le Royaume-Uni.
 1791 : l'Espagne cède Oran et Mers el-Kébir à la régence d'Alger.
 1808 : les Anglais évacuent l'îlot Persil en 1813 à la demande du roi d'Espagne Ferdinand VII.
 1811 : les Cortes de Cadix déclarent que les « presidios menores » ne font pas partie du territoire espagnol et un vote favorable à leur cession obtient la majorité des voix.
 1859-1860 : profitant d'un incident aux frontières de la ville et de sa supériorité militaire vis-à-vis de son voisin, l'Espagne déclare la guerre au Maroc (guerre hispano-marocaine), la remporte et élargit les frontières de Ceuta et de Melilla.
 1902 : négociations entamées entre le Foreign-Office et le Makhzen pour la cession de l'îlot Persil.
 1925 : la ville devient indépendante de la province de Cadix.
 1936-1939 : guerre d'Espagne dont le soulèvement militaire commence dans le protectorat du Maroc.
 1995 : Promulgation du Statut d'autonomie de la ville, suivant l'aménagement du reste des territoires d'Espagne.
 2007 : à la suite de l'annonce officielle de la visite du roi  et de la reine Sofía à Ceuta et Melilla, le roi Mohammed VI du Maroc rappelle son ambassadeur en Espagne pour consultations (jusqu'au ). Des manifestations de protestation ont lieu au Maroc pendant la visite.

Statut et administration
La Constitution de  autorise Ceuta à se constituer en une communauté autonome. Entre  et 1991, Ceuta n'a pas eu recours à cette disposition et a constitué une commune de la province de Cadix. En , les Cortes Generales adoptent la loi organique accordant à Ceuta le statut de ville autonome ().

La gouvernance décentralisée de la ville repose sur deux organes :
 l'Assemblée, constituée de vingt-cinq membres élus pour quatre ans et qui exerce le  ;
 le président, qui préside le conseil de gouvernement, l'Assemblée et exerce le rôle de maire.

Ceuta ne constitue donc pas une communauté autonome, à l'image de l'Andalousie, mais bénéficie d'institutions spécifiques, hybrides entre celles d'une ville et celles d'une autonomie.

Avant l'entrée de l'Espagne dans ce qui était alors la Communauté européenne, en 1986, la ville avait eu le statut de port franc. L'enclave est incluse dans l'Union européenne.

Population et société

La population, d'origine espagnole et marocaine, comporte près de 45 % de musulmans.

Le castillan, langue officielle de l'État espagnol, est la seule langue officielle de Ceuta (la Cité Autonome de Ceuta ne reconnaît aucune langue co-officielle). Cependant, la population espagnole d'origine européenne et ayant le castillan pour langue maternelle ne compte que pour 55 % de la population totale. La population d'origine marocaine, qui compte environ 45 % de la population, a pour langue maternelle l'arabe ceutien, appelé dariya par le gouvernement espagnol.

Les habitants d'origine européenne sont pour la plupart unilingues, tandis que les musulmans sont la plupart du temps bilingues. Les autres groupes ethno-linguistiques sont peu représentés : les Juifs parlant le judéo-espagnol (plus particulièrement la jaquitía), la langue des Berbères, la langue sindhi parlée par les Roms, le portugais et le français.

Économie
Le secteur tertiaire joue un rôle important dans l'économie de Ceuta. L'agriculture et l'élevage étant rares, la pêche est la seule activité importante dans le secteur primaire. Le relief accidenté et la pénurie d'eau, d'énergie et de matières premières ont empêché le développement de la ville. De même, tant le secteur secondaire comme celui de la construction sont très restreints en raison du prix du foncier de plus en plus cher, bien que ce dernier secteur ait connu un développement remarquable au cours des dernières années. Ceuta, comme Melilla, a un statut de port franc. Elle bénéficie également d'un certain nombre d'avantages fiscaux, tels que des allégements fiscaux.

Contrebande
Chaque jour, entre    transportaient des paquets de dizaines de kilos contenant des marchandises de contrebande, qu'elles faisaient passer entre Ceuta et le Maroc. Elles essayaient de traverser la frontière autant de fois que possible dans une même matinée pour gagner en fin de journée l'équivalent de quelques dizaines d'euros. Le métier est considéré comme des plus pénibles. En 2018, deux d'entre elles sont mortes en traversant la frontière et 84 ont été blessées d'après le rapport parlementaire marocain, un chiffre qui sous-estime la réalité selon des ONG espagnoles.

Ceuta exportaient chaque année pour sept cents millions d'euros de marchandises au Maroc.

Le mercredi 9 octobre 2019 les autorités douanières marocaines de Bab Sebta ont officiellement annoncé leur décision de la fermeture du passage frontalier Tarajal II servant jusque-là au transport des marchandises.

La fermeture des postes frontières de Bab Sebta ainsi que celui de Bab Mélilia a contribué à une augmentation des recettes douanières de 4 MMDH (milliards de dirhams) », ce qui a causé de grosses pertes économiques du côté espagnol.

À la suite d'une rencontre entre les deux ministres des affaires étrangères marocain et espagnol, Nasser Bourita et José Manuel Albares, le mercredi 21 septembre 2022 à New York, en marge de l'assemblée générale annuelle de l'ONU, les deux ministres ont annoncé œuvrer pour la réouverture des douanes courant janvier 2023.

Édifices

 Cathédrale Sainte-Marie de l'Assomption ;
 Église Saint-François d'Assise ;
 Église Sainte-Marie d'Afrique ;
 Église Sainte-Marie du Recours ;
 Église Sainte-Thérèse de Jésus.
Ces églises catholiques dépendent du diocèse de Cadix et Ceuta qui, lui-même, relève de la province ecclésiastique de Séville.

Arènes
Les arènes de Ceuta furent construites en 1918, à Las Damas.

Revendications marocaines
Depuis son indépendance en 1956, le Maroc revendique cette enclave, tout comme Melilla et les autres Plazas de soberanía, ceci bien que dans le traité de cessation du protectorat il ne fût fait mention des deux enclaves (existantes avant ledit protectorat espagnol) ou comme n'étant pas « continental » car insulaires pour les « présides ». Pour le Maroc, il s'agit d'un vestige du colonialisme et les médias marocains évoquent Ceuta comme « le préside occupé de Sebta ». L'Espagne considère pour sa part Ceuta comme faisant partie intégrante de son territoire, depuis 1995 en tant que ville autonome ou « autonomie » comme les autres régions espagnoles, et comme partie intégrante du Royaume d'Espagne depuis 1580 et 1415 par « rétroactivité hispano-portugaise » comme indiqué dans l'historique ci-dessus.

Soutien et statut international

La souveraineté espagnole sur Ceuta et Melilla n'est reconnue ni par la plupart des pays d'Afrique, ni par l'Union africaine, ni par l'Organisation de la coopération islamique, ni par la Ligue arabe, ni par l'Union du Maghreb arabe. Les pays membres de ces quatre organisations considérant que l'Espagne doit décoloniser ces territoires et les restituer au Maroc. Ces territoires revendiqués, espagnols ou portugais depuis près de six cents ans, ne font cependant pas partie de la liste des territoires non-autonomes en attente de décolonisation de l'ONU. L'Union européenne aide à financer la politique de lutte contre l'immigration clandestine dans cette région, et considère comme dépendance européenne les dépendances des États de l'Union (départements et territoires d'outre mer français, dépendances et îles éparses néerlandaises, françaises, danoises, et ici même espagnoles).

Crise migratoire

Étant les seuls points de passage terrestre direct avec le continent européen, Ceuta et Melilla sont sujettes à un afflux migratoire en provenance du Maghreb et de l'Afrique subsaharienne. Chaque année, des centaines de migrants tentent de traverser la frontière pour se rendre en Espagne.

En  une entrée massive de migrants à Ceuta provoque une augmentation de la tension entre l'Espagne et le Maroc.

Dans la nuit du 16 au , des milliers de migrants ont traversé à la nage ou à pied la frontière entre le Maroc et l'Espagne. Plus de huit mille, dont beaucoup d'hommes jeunes, des femmes et des mineurs. Cette crise migratoire, sans précédent pour l'Espagne, aurait été orchestrée par le Maroc alors que les relations entre les deux pays se sont envenimées depuis l'accueil, fin avril 2021, en Espagne du chef des indépendantistes sahraouis du Front Polisario, Brahim Ghali, pour y être soigné du Covid-19. Ennemi du Maroc, il est notamment accusé par Fadel Breika, un opposant politique sahraoui, de « détention illégale », « tortures » et « lèse-humanité ».

Jumelages

Personnalités liées à la ville

 Soledad Ruiz Seguín, syndicaliste et femme politique née à Ceuta en 1962
Mounir Erramach, baron de la drogue né à Ceuta.

Notes et références

Voir aussi

Bibliographie

 .

Articles connexes
 Barrière de Ceuta
 Diocèse de Cadix et Ceuta
 Frontière entre l'Espagne et le Maroc
 Plazas de soberanía
 Melilla

Liens externes

  Portail de la mairie

Capitale de province en Espagne
Cité carthaginoise
Cité romaine au Maroc
Ville frontière
Espagne extrapéninsulaire


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redpajama_set_name: RedPajamaCommonCrawl


Science week began with an investigation into Weather and Wind. We had some terrible weather on Monday evening and the children wanted to learn more about why. We started off by assessing the damage done to the trees in the KS1 playground and then we watched the BBC Weather forecast to see if it would get much better.
We learned a lot about temperatures, UK geography, rain and wind, but we wanted to know more! We began our research into wind directions and how we measure which way the wind is coming from.
The children were set a challenge to monitor the weather for the week and record which direction the wind was coming from, on the school field.
The children learned how to make weather vanes and what they would tell us about the wind and possibly the weather too. We needed to know lots about compass directions so that we could set our weather vane up correctly.
Here are the children using their weather vanes for the first time. If you want to know more about the wind and weather, please come and have a look at our Wind Roses. A special type of chart used to monitor wind direction.
We also created some amazing paper planes for a competition. The children loved making them, practising their folding techniques and making them fly as far as possible. We used a great website to gather different ideas and designs in order to make the bast possible plane.
Our third investigation for the week focussed on whether plants needed soil in order to grow. The children devised their own fair test to see if Sunflowers would grow in gravel and sand. Keep an eye out for the updates coming up over the next few weeks.
You can also see the results of our paper making investigation, where we tried to produce paper good enough to write on. We used grass and plastic as well as some torn up old paper, with glue and water to produce a pulp. The pulp was rolled out and dried on a mesh frame. Eventually we were able to try and write on it with a selection of pens, pencils and felt tips. The pictures of our paper are towards the end of the video.
This entry was posted in 1DJ, Events, Key Stage 1 and tagged paper, planes, plants, science, wind on June 4, 2015 by Mr Jackson.


Should all armies have chapters?
Who is your favorite HQ ?
Can I use an Inquisitor in a kill team?
What is the Best mech army?
What would make tankshock worthwhile?
What do you think abou GW Customer Services?
what or where are rules for void shields?
Don't hate me... But I'm curious.
need a cool name for a titan.
anyone else here started to lose interest in the hobby?
40k Mobility and How it Can be Applied.
How do your characters interact?
Anybody Playing Kill Team? Is it worth the effort?
[BatRep] Necrons at RTT Guest Starring TheLetterV!
Funniest/ Unluckiest 40K battle ever?
Jump Pack Infantry and Assaulting.
Which army do you prefer to play against?
Need help deciding on army!!
United call, Tau online, I need your ears.
Bolter, Ccw, AND a Bolt Pistol?
Who actually won the Dark Crusade?
Obssessive hobby drive - ever experienced/experiencing it before?
US GW's new site layout...what happened?
Terminators..Whats the point of Initiative?
Which is the most popular army ???
Ever Had Anyone throw a Tantrum, Pack up and Leave During a Game?
Looking for something a little different.
Get's Hot - which statistics to use?
How to convince an independant store to host Warhammer 40k.
Storm Shield rule please Help!!
Where can I download Mathhammer?
Rituals of the Dice Gods?
Characters attached to squads; Question.
GRIM DORKNESS- new 40k webcomic!
What are the most common build types for GTs?
What's in the 3rd Edition Box Set?
Quick question on rapid fire weapons.
I got a free 40K rulebook.
Forcing a model to make more than one save?
standard table size question. 6x4?
How much of scratch built must be 'scrach built' for a tourniment?
What is your favorite sprue?
When do games stop being fun for you?
How does tank shock work against a unit thats already falling back?


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Event Management Company, Modelling Agency Mumbai, India.


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Music. Theatre. Dance.
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Collaborative Arts: Voice & Piano
| $15 Get Tickets
Hailed by The New York Times for a voice that is "fully powered and persuasively expressive," baritone Matthew Worth and critically acclaimed pianist, conductor and clinician Tyson Deaton partner to explore the powerful collaborative relationship between pianist and vocalist.
Alan Louis Smith: Daniel Boone Sings to the Night Sky
Charles Ives: At the River
Charles Ives: The Housatonic at Stockbridge
Charles Ives: The Children's Hour
Charles Ives: The Things our Fathers Loved
Charles Ives: The Circus Band
Samuel Barber: Three Songs, op. 10
Andrew Staniland: Peter Quince at the Clavier
Lowell Liebermann: Six Songs on Poems by Raymond Carver, op. 80
Hailed by The New York Times for a voice that is "fully powered and persuasively expressive," Matthew Worth is quickly becoming the baritone of choice for innovative productions and contemporary works on the operatic leading edge. Last season, he created the role of the Narrator in the world premiere of The Passion of Yeshua with the Oregon Bach Festival. The Register-Guard praised, "Baritone Matthew Worth sang the critical role of Narrator. His voice was rich and vibrant, his diction clear and his delivery earnest." This season he will return to the role at Royce Hall in Los Angeles and again with the Buffalo Philharmonic.
The 2018/19 season also included Worth's return to Boston Lyric Opera as Figaro in Rosetta Cucchi's zany production of Il barbiere di Siviglia and a workshop performance of Laura Kaminsky and Kimberly Reed's Postville, commissioned by Santa Fe Opera and San Francisco Opera.
Along with The Passion of Yeshua in the 2017/18 season, Worth performed the title role in David T. Little and Royce Vavrek's JFK with Opéra de Montréal, Bernstein's Arias & Barcarolles with the New York Festival of Song at Lyric Opera of Kansas City, Laura Kaminsky and Mark Campbell's As One with Cincinnati Opera, and recitals at the University of Cincinnati and Austin Peay University.
Highlights of recent seasons include the title role in the world premiere of JFK with Fort Worth Opera, the world premiere of The Manchurian Candidate with Minnesota Opera, and Moby Dick at Washington National Opera. Also lauded for his work in the standard operatic repertoire, Worth's Guglielmo (Così fan tutte) was deemed "vocally impeccable…open and incisive" by Boston Classical Review. Other notable appearances include the title role in Don Giovanni, Dottore Malatesta (Don Pasquale), Mercutio (Roméo et Juliette), Valentin (Faust), Harlequin (Ariadne auf Naxos), and Tarquinius (The Rape of Lucretia). He has performed leading roles at Santa Fe Opera, Lyric Opera of Chicago, Castleton Festival, Tanglewood Festival, Pittsburgh Opera, and Opera Theatre of Saint Louis, under such luminary conductors as James Levine, Lorin Maazel, and Sir Andrew Davis.
Worth is a committed recitalist and active concert soloist. He performed Schumann's Dichterliebe and Mahler's Songs of a Wayfarer with the Santa Fe Chamber Music Festival, and was praised by The New York Times as "simply superb, singing with exquisite sensitivity." He made his Carnegie Hall debut in Brahms' Ein deutsches Requiem under James DePriest while still a student at the Juilliard Opera Center. He made his Alice Tully Hall debut with the Richmond Choral Society in Carmina Burana and has since been featured in concerts with the Atlanta Symphony, the Philadelphia Orchestra, and the Boston Pops Orchestra, and has performed with conductors Donald Runnicles, Robert Spano and James Conlon.
Visit www.matthewworthbaritone.com to learn more.
Known for his broad range of repertoire and versatility of style, American conductor Tyson Deaton has established a reputation for leading energetic and inventive performances. With his musical roots firmly planted in the traditions of the standard operatic repertoire from the Baroque Era to Puccini and beyond, his affinity for contemporary works is also acclaimed by audiences and critics.
Deaton is frequently entrusted with the development and premieres of new works as a musical authority, specifically with vocal and orchestral writing. He led workshops for The Falling and the Rising, by Zach Redler and Jerre Dye, co-commissioned by the United States Army Soldiers' Chorus and Field Band, and conducted the premiere of this work along with subsequent performances in New York City earlier this season. He has also worked on Matthew Peterson's Voir Dire and Libby Larsen's technologically innovative operatic version of Madeline L'Engle's A Wrinkle in Time. Other recent premieres include The Companion and Safe Word from Robert Paterson and David Cote's opera triptych, Three Way, and Tarik O'Regan and Anna Rabinowitz's The Wanton Sublime, both with American Opera Projects in New York City.
Additional highlights include Hal Prince's production of Candide with New York City Opera, American Modern Ensemble's productions of Robert Paterson and Mark Campbell's The Whole Truth, and Stewart Copeland and David Bamberger's version of The Cask of Amontillado. Deaton has opened the Anchorage Opera conducting Lucia di Lammermoor, while two other pinnacles of the Bel Canto canon, Norma and Guillaume Tell, rounded out his season.
He joined San Francisco Opera for their production of Sweeney Todd, soon followed by his debut at Opera Birmingham with L'elixir d'amore. As guest conductor, he also played continuo for Le Nozze di Figaro at The Janiec Opera Company at the Brevard Music Center.
Tyson Deaton made his Fort Worth Opera debut in the inaugural production of the Opera Unbound series with Tom Cipullo's Glory Denied, and is heard on the premiere recording this work on the Albany label. Lauded as Best of 2013 in the Washington Post, it was also rated among the 12 Best Full-Length Opera Recordings of 2014 by OperaNews. Other digital releases include the Offenbach rarity L'île de Tulipatan (Albany), and with Julia Kogan, In Jest, (First Hand Records – UK) recorded at Champs Hill.
Adept on the concert stage as well as in the orchestra pit, Tyson Deaton has partnered with artists including Denyce Graves, Michael Norsworthy, Talise Trevigne, Linda Wang, Judith Kellock, Julie Landsman, Victoria Livengood, Craig Mumm, Othalie Graham, and Sherrill Milnes, among many others. Along with Steven LaBrie, he collaborated with the Jessica Lang Dance Company on a staged version of Die Schöne Müllerin at the Brooklyn Academy of Music, "render[ing] the score with compelling artistry," according to The New York Times.
Deaton has been presented in recital alongside Matthew Grills at the John F. Kennedy Center for the Performing Arts, which included Benjamin Britten's Canticle I, one of the featured events celebrating that composer's centenary. He performs regularly with baritone Matthew Worth: their most recent program touches three centuries of the American musical heritage. A fervent advocate for the music of our time, Deaton has commissioned a number of works including David T. Little's setting of To a Stranger, co-commissioned by The Walt Whitman Project of New York.
Deaton's academic appointments have included those at the University of the Pacific and Lawrence Conservatory, and as an artist-in-residence at McGill University in Montreal. The singers he has coached occupy the rosters of The Metropolitan Opera, Bayerische Staatsoper, New York City Opera, San Francisco Opera, Deutsche Oper Berlin, Houston Grand Opera, Paris Opera, The Barbican, Oper Frankfurt, La Scala and other major opera houses throughout the world.
As a clinician for both pianists and singers, he is often invited to give masterclasses and lectures on collaborative and operatic literature. For Opera America he has served as a panelist for Making Connections and Career Blueprints workshops, commissioning grants, and is a featured contributor to their ArtistLink publication. He has adjudicated the ASCAP Plus Composer Awards, and was a primary interviewee for an article centered around post-secondary classical vocal music education for ClassicalSinger magazine in the September 2013 issue.
Deaton's extensive experience as a pianist, coach, recitalist, chamber musician, and his training and work as a singer, give him a unique perspective in understanding the demands of the whole performance as a conductor: offering advice, compelling, or following as needed and, above all, encouraging individual artistry at the highest level.
Visit www.tysondeaton.com to learn more.
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Diabetes News August 13th 2010
The organisation & delivery of diabetes services in the UK: a scoping exercise
This scoping exercise will provide an overview of current developments in the organisation and delivery of diabetes services in the UK – download final report (NHS, NIHR)
Comparison of diabetes management in five countries for general and indigenous populations: an internet-based review
The aim of this review was to provide an overview of diabetes management in five selected Organisation for Economic Co-operation and Development OECD countries (Australia, Canada, New Zealand, the US and the UK), based on data available for general and indigenous populations where appropriate (BMC Health Services Research)
Mixtard 30 – going, going, gone?
The withdrawal of Mixtard 30 will have a major impact on patients, healthcare professionals and healthcare expenditure (Drug and Therapeutics Bulletin)
Shining a light – literally – on diabetes
Device from MIT's Spectroscopy Lab could help diabetic patients monitor their blood glucose levels without finger pricks (MIT News)
Gluco oxidative stress in the diabetic kidney
This brief review has discussed the functions of RAGE, and its potential as a therapeutic strategy in managing diabetic nephropathy. It has tried to simplify a difficult aspect of pathophysiology of diabetes/diabetic nephropathy, to enable family practitioners understand the advances taking place in this field of science (The Internet Journal of Family Practice)
Type 2 diabetes – controlling hyperglycaemia with early insulin use
In general, initiation of insulin should be considered in individuals on maximal tolerated doses of metformin and sulfonylureas with HbA1c levels >7.0% over a 3–6 month period. Current Australian guidelines recommend initiating insulin therapy as once daily basal therapy or as premixed insulins (Australian Family Physician)
Iron Overload in Diabetic Retinopathy
A Cause or a Consequence of Impaired Mechanisms? (Experimental Diabetes Research)
Endothelial-myofibroblast transition, a new player in diabetic renal fibrosis
Recent evidence from our laboratory and others suggests that EndoMT plays an important role in the development of renal fibrosis in several pathological settings, including experimental DN. This review considers the evidence supporting the occurrence of EndoMT in normal development and in pathology, as well as the latest findings suggesting EndoMT contributes to fibrosis in DN (Nephrology)
Categories: News Pre-2012


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CHINMOKU [Crònica, 2018]
electro-acoustics
Software: Ableton Live; CsoundQt; Cecilia
Hardware: Oktava MK012 Cardioid Condenser Mic; SoundDevices MixPRE-6
Chinmoku means Silence in Japanese and is a track listed in Panphonia, an album by Vacuamoenia released by Crònica in 2018. It's a study on the materials present in a Dojo Zen, a place where silence manifests itself as an austere essentiality.
The Hokku beating time for the mantra of the Haramita Shingyo; the Mokugyo establishing the return to the profane time and finally the bells are the main sound events that inspired this composition.
The work is technically the digital treatment of a ritual metal bell closely recorded; the form is that of sound stratifications elaborated in real time and then edited in studio.
Panphonia by Pietro Bonanno
OVER THE HORIZON [2017]
Software: Logic ProX; CsoundQt; Cecilia
Sources: WebSDR Radio
Over the Horizon is an electronic composition based on sampling, treatment and interaction of multiple sound sources recorded among short-wave frequencies between 2 and 30 MHz. The idea behind the composition is to create a dialogue between technical frequencies (OTHR, R2DBI and CODAR) and broadcasting (BSKSA Holy Quran, Radio Saudi) to investigate the distance from a geographical and cultural point of view. So Ocean Radars and the voice of the Arab Singer serve as imaginary circumference of a center in which is placed the listener, from anywhere in the world he comes from. The materials—recorded by Twente (NL) WebSDR —were treated with CSound through techniques related to the modulations used in the radio (AM) and granulation. The constant rate of the OTHR is the primary component in the broader rhythm of the composition, hence the title.
The composition was presented for the first time at Wave Farm WGXC 90.7-FM: Hands-on Radio Short Waves / Long Distances transmission and transmitted 2017, 05th july during the 14th Sound and Music Computing Conference 2017 at Espoo, Finland.
You can listen the composition at the Wave Farm Repository here.
SCAPE #002 [2010]
electro-acoustics; soundscape
Scape #002 delves into two aspects that were investigated in the first Scape: the first one is the cyclicity of sound-events, indeed every sound happens (and this is probably the difference between a classic composition and a soundscape one) thanks to a slowly used drum machine; the second one is the placement by distance of the sound-textures. In this regard, through the use of piano chords that recall Morton Feldman, I tried to deepen this distance even inside a house that is imaginatively placed far away, on a hill (it's my dreamy topos to remember a house as a child I always saw a hill above). The hoe that scratches the ground becomes a rhythmic scheme for the whole composition, an analogy with the piano that scratches the silence.
Scape #001 is an investigation on Soundscapes Composition and was presented for the first time at Terra Fertile, 2010 in Sassari, Sardinia. Recordings made in what was soon to become my home have been fragmented and inserted into a drum machine recombining materials at a very slow time. Everything was then filtered to create real or presumed distances.
In 2015 Scape #001 was part of Making Presence Felt, a Fiona Candy installation commissioned by Northampton Museum and Art Gallery (UK)
Making Presence Felt (with stereo 19.01.16) from Fiona Candy on Vimeo.
ALL THE STONES OF OUR LIVES [Treetrunk, 2009]
All the stones of our lives was released with the pseudonym AON under Treetrunk in 2009 and was created, edited and mastered in Solios, a Damanhur community built in Altofonte, Palermo. AON anticipates ten years before Reverberant Evenings, started when I realized that Drone production needed a different subject. ATSOUL is the crossing of two sound-textures produced by the time-stretching of two soundscape recordings (shooted in Solios), the first one non-harmonic and non-periodic, the second one harmonic and, in particular, consonant. Both traces of the release focus on this single process.
MUSIC FOR FLYING PLANES [Essentiamundi, 2008]
Music for flying planes is a 5 pieces composition released by Essentiamundi in 2008. It is a textures sound-work that takes inspiration from some recordings of airplanes in flight made at the beginning of 2007 in Monte Pellegrino, Palermo; in particular I wanted to pay attention to the resonances during their passage through digital resonators and reverberations. It is a release that deepens the concept of Drone Music and it is inspired by the dialogues that at that time I had via email with Gianluigi Gasparetti (Oöphoi), who died in 2013, with whom I talked a lot about airplanes and helicopters in flight, sounds that both we loved.
The photos of the album were taken at the Torino, Italy airport during the journey back from my initiation to the community of Damanhur (community that I left a few years later) and about the names of the tracks, they are a small poetry born at the end of a meditation session in the community.
Music For Flying Planes [EM006] by Pietro Bonanno
INSTANCABILE SILENZIO [2007]
Instancabile Silenzio (Tireless Silence) is a work that defines a Choice: to work on the border with Silence. This is not just a philosophical statement, a generic aura that focused the composition on absence, but also a practical one: the search for the right volume, not completely considering the idea of Loudness; the rarefaction of materials; the loss of paternity through the introduction of initial data into a software generating organization that takes on a life of its own until it is dissolved.
The work was broadcasted, and still is, in Sleepbot radio – even this project created, initially managed and then left to its course by Dan Foley.
GHIACCIO [2007]
Ghiaccio (Ice) was created after having discovered Sleepbot Radio that broadcasted ambient/drone/isolationist music with the purpose to make people fall asleep. There I discovered Oöphoi – with whom I had an interesting exchange at that time and I will always remember him – and the sound textures world.
Ghiaccio is the experiment (also in formal terms) that anticipates Instancabile Silenzio. Each sound material of the composition originates from the previous one, through a particular loop machine that manages the repetitions, the spectrographic materials and the file speed with particular envelopes. The loop machine I used was created with MaxMSP and then I called it Kaleidoscope in 2011.
RIVELAZIONE DI CRISTALLO [2005]
Rivelazione di Cristallo (Crystal Revelation) was composed more or less in the same period of Bethsaid, while I was beginning to experiment with numerical signal processing softwares and codes (in particular CSound). What I always have in mind is to create processes not compositions and sometimes something comes to life on its own. This is the case.
BETHSAID – Studio sulla Rarefazione [2005]
Bethsaid is the first composition of digital music I made and it was presented for admission to the course of Electronic Music in Palermo Conservatory on September 20th, 2005. Bethsaid was a term used in Egyptian/Essene therapy to describe the place where Therapy took place and it is dedicated to Paolo and Silvia, two Masters who introduced me to this philosophy at that time.
Bethsaid should not have been this way. After a voltage drop, everything I had done on the computer on reboot was digitally shuffled a few days before the exam. Incredibly it was much better than before! The final version is a manipulation of these errors.
Bethsaid in 2011 was the soundtrack of the beautiful work of Paolo Minioni Gleis 17 Berlin Grunewald presented on January 27th, 2011 at ABF | Scatola Chiara. Piccola Galleria per la Fotografia Storica (Torino, Italy)
Gleis17 Berlin Grunewald from Paolo Minioni on Vimeo.


Today we ventured out to Tom's Farm at the suggestion of Fiona. It was awesome! We all enjoyed the music, shopping, and sights. Matthew liked it even better than Disneyland.
We started off at the petting zoo where there were baby goats, piglets, and chickens. Adorable!
Next we went into the furniture store (where I found my next couch - leather with dual recliners) and Matt threw a tantrum.
Then we rode the train into the wilderness, through an Amish style bridge, and back. Matthew refused to sit still until we started moving which reminded me once again how nervous I am for Wednesday's flight.
Finally, we rode the carousel where Matthew made his parade debut. He waved at everyone all the way around and thought he was the star of the show. "Weeeeeee!"
What a fun day. Thanks Fiona for suggesting and Aunt Beth for treating!
We recently got a leather couch with dual recliners. It's actually pretty uncomfortable for me since I am short. It hits my neck in a bad place. Who knew? So I spend a lot of time with a pillow behind me. Make sure you really try it out before you buy one. Us shorties are at a disadvantage!
Oh, and the farm sounds like a cool place to visit. I may need to try it on one of my visits!


Since all of our 'Mammas' have different halfway points we each did our own boxes to celebrate the occasion. For my son's 'One Year Half Way Through' Box I decided to swap things up from the traditional 'Camel' and 'Hump Day' boxes by doing a Minion Themed District Party in a Box. It turned out really cute and I included something for all 6 Missionaries in his District so they all could celebrate with him. I found out afterwards that it just happened to also be one of the other Elder's and also one of the Sister's Hump Day as well – so it turned into quite the party!!!
If you would like to send your own 'Hump Day Box' to your Missionary – check out this kit we put together to help you do just that!
Passing your One Year Mission Mark is truly an accomplishment and one worth celebrating! Since we can't be there in Spain with you to throw a Fun Party ~ I decided to send you one that you can throw for the 6 of you in your District!!!
So, Instructions for Your One in a Minion Celebration!!!
1. Carefully pull out the 6 wrapped in cellophane cups and set to the side – but don't open them yet.
2. You should see a cute blue t-shirt and plaid tie in your box just for you.
3. Under those you should see a cake, some frosting, and some brownie mix. Those are the only other things you should take out of the box for now.
4. Carefully put back in the 6 wrapped in cellophane cups inside the box and keep until Party Day.
5. On the day of your District Party ~ Bake your cake, then frost it, and bake the brownies.
6. When all 6 of you are together you can unpack the rest of the box. Each District Member will have their own Cup with His or Her name on it.
7. Tell Each One of them that I send My Love and Big Hugs to them! I am so happy that they are there with you in Spain to Celebrate.
8. Tell them that this party is for them too! They are amazing and fabulous and I hope you all have the mostest wonderful party EVER!!!
3. Party Sunglasses (Multiple Designs) I picked 6 different crazy ones!
3. Party Candle #1 (Yellow with Colored Polka Dots on it) For 1 Year Completed!
6. Hostess Twinkies (Pkg. of 10) I bought 2 boxes and was able to get 4 more Twinkies snuggled into the box decorated like Minions!
13. Snickers Mini's Party Pack 40oz.
One of my favorite finds was a Minion Bodywash – it smelled like Strawberry Banana! Yum!


What is the best way for a curious developer to learn how to create their own version of bitcoin?
What is Bitcoin Block Header SIZE in bytes?
Every Bitcoin block has a HEADER which is a small fixed size data structure. What is Bitcoin Block Header SIZE in bytes?
I am using a mobile Bitcoin Wallet app by Andreas Schildbach. Now I need to restore my wallet because I have lost my phone. I am lucky that I have made backup of my wallet earlier. However I cannot figure out how to do a wallet restore. Please advice!


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Mason Dunn, JD
Mason J. Dunn, JD (he/they) is the Deputy Director of Education and Training Programs and the Fenway Institute. Mason is an attorney, and brings their legal and advocacy experience to the Institute. They have worked in the LGBTQ+ equality movement for over 15 years across the country. Prior to joining Fenway, Mason was Executive Director of the Massachusetts Transgender Political Coalition where they successfully advocated for the advancement of nonbinary gender markers on Massachusetts state ID's, participated in coalition to address restrictions in healthcare and gender marker changes on Massachusetts birth certificates, and worked to build the coalition which passed state-wide nondiscrimination protections in public accommodations for transgender and nonbinary people. In 2018, Mason co-chaired the historic 2018 Yes on 3 campaign, which successfully defended the Massachusetts' trans-inclusive public accommodation nondiscrimination law, in the nation's first ever state-wide vote on transgender rights. Mason has also worked in state and local advocacy with GLSEN, Keshet, and many state-based equality organizations across the country.
Beyond their full time work, Mason teaches at UNH in Manchester in the Communication's Department, is a board member with The Equality Federation, and serves on the state Commission on LGBTQ Youth. Mason is a member of the New Hampshire Bar Association, and a 2012 graduate of the University of New Hampshire School of Law with the Daniel Webster Honor's Scholar Program. Mason has received multiple awards and honors including: the Boston University School of Public Health Gail H. Douglass Award for Excellence in Public Health Practice, the University of New Hampshire Kidder Award for LGBTQ+ Inclusivity in Education, and JALSA's Advocate for Justice award.


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Q: HDD in external case SATA/USB3.0: stop automatic disk switch off I recently bought a sharkoon swift case pro USB3.0, external 3.5" HDD case/enclosure. The problem(s) is:
When I reboot windows (doesnt matter which version it seems, tried both xp/7), the case shuts down the hdd and starts it again (this is the worst thing for a mechanical disk).
Strange thing is that when you forcefully remove the USB cable while the case is ON, the HDD wont shut down; this is to expected because its the case that gives the power to the HDD.
Also the HDD shuts down after a while, when inactive until I access the disk (power saving).
It seems that (not 100% sure though) this won't happen if the enclosure and the HDD are ATA (old connection cables).
So, how to keep the hdd ON as long as the case is ON? Is it just this case or it also happens with other SATA/USB cases as well?
Edit: It would be informative if you could share your personal experience (if any of course) with SATA/USB cases.

A: The firmware of this enclosure does this. Nothing to do about it (unless someone has the level to hack it)

A: You have two options to attack the problem:

*

*In Windows: Prevent the USB-to-SATA-Adapter from giving the instruction to power down the drive based on the assumptions Windows does make - which can be a problem if the adapter in use does not provide enough sensor-data to Windows (either due to the adapter or a generic driver). You achieve this by enabling the disk-cache in the properties of the drive. When you do that you are forced to unmount the drive manually.

Alternatively, if you are able to prepare a linux-live-system on a USB-drive - for example Ubuntu or Fedora:

*You may access the drives settings e.g. via the "Disks"-tool provided by the Gnome-Desktop. If the adapter allows it you may be able to access the spinup-rate and automatic-powerdown setting of the drive and set it to not powerdown. This "might" hinder Windows from giving the order to powerdown the drive - assuming the adapter does translate/report the drive-configuration correctly.

While there are other ways to try to achieve this, they require a deep understanding of the hardware, the interfaces and require absolute precision when applying the commands, which is only possible in a terminal and by attaching the actual drive directly (without the adapter in between) to an internal SATA-controller - and even then are not guaranteed to provide a solution.

redpajama_set_name: RedPajamaStackExchange


Elegant handmade Plain and Simple pattern, pressed glass.
Ruby Red Handmade 8" Tall Pressed Glass Panel Pattern Candlestick This heavy candlestick stands 8" tall and about 4¾" in diameter at the base. It was handmade By Mosser and the condition is excellent unused new, no chips, cracks or scratches.
Amethyst Pressed Glass Panel Pattern Glass Oil Cruet Made by hand in the U.S. by the well-known Mosser Art Glass Company this cruet is about 5½" tall and 3½" across at the widest point.
9'' Crystal Cake Pedestal Stand Plate Here is a great handmade cake stand that is a full 7" tall and about 9¼" in diameter. This wonderful pedestal is unsigned, handmade by Mosser and is in excellent unused new condition, no chips, cracks or scratches. This is a wonderful piece that displays exceptionally well; use it for cake, cookies, cupcakes or anything else you can think of. This will make a great addition to any collection! For a spectacular display get all three sizes (6", 9",and 12") and stack them.
Crystal 10'' Cake Stand Pedestal Plate Here is a wonderful crystal cake stand or pedestal that is about 8" tall and 10¼" in diameter. This beautiful piece appears to be unsigned but was handmade by Mosser Glass and is in excellent unused new condition, no chips or repairs. This extraordinary piece displays exceptionally well and will go nicely in anyone's collection!
Jadeite Jadet-ite 6in. Plate Here is a very nice Jadeite cake or desert plate. It measures about 5 ¾" across and the condition is mint unused, no chips, cracks or scratches. This will make a great addition to anyone's Jadeite collection.
9'' Vaseline Glass Cake Pedestal Stand Plate Here is a great handmade Vaseline Glass cake stand that is a full 7" tall and about 9¼" in diameter. This wonderful pedestal is unsigned, handmade by Mosser and is in excellent unused new condition, no chips, cracks or scratches. This is a wonderful piece that displays exceptionally well; use it for cake, cookies, cupcakes or anything else you can think of. This will make a great addition to any Vaseline Glass collection! For a spectacular display get all three sizes (6", 9",and 12") and stack them.


text:
Die Alte Wöhr ist ein Fließgewässer und Entwässerungsgraben in Hamburg-Winterhude und Nebengewässer des Barmbeker Stichkanals.

Er beginnt südlich der namensgebenden Straße Alte Wöhr und verläuft östlich der Saarlandstraße bis zum Barmbeker Stichkanal.

Einzelnachweise

Hamburg-Winterhude

redpajama_set_name: RedPajamaWikipedia


text:
Evolving the Scope of the Strategic National Stockpile
by Greg Burel - Wed, November 27, 2019
While the mission of the Strategic National Stockpile (SNS) has not changed since Congress established this national repository of emergency medicines and supplies, public health events in the United States during the past 20 years have led to a dramatic expansion of the scope of the stockpile's capabilities. Originally focused on protecting Americans from bioterrorist threats surrounding the year 2000, or Y2K, the stockpile has grown and evolved to a greater than $8 billion enterprise that contains more than just medical countermeasures (MCMs) for biological and chemical threats. The mission authorized is broad enough to encompass virtually any threat to national health security, and the progress SNS has made operationally lends it to encompassing a continually evolving landscape of risks that might be mitigated.
Post-Disaster Death Figures Do Not Tell the Whole Story
by James M. Rush Sr. - Wed, November 06, 2019
In any disaster, there is a cost beyond the immediate mortality figures following a disaster due to a lack of proper medical supplies and treatment in mass care shelters. The Centers for Disease Control and Prevention publishes a weekly "Morbidity and Mortality Weekly Report," which serves as a clearinghouse for epidemiological reports submitted by state health departments. However, a public health method must go beyond the death tolls and rates and estimate the years of life lost for people who were without medications and treatments (like dialysis) for extended periods of time during and following disasters.
Overcoming Challenges of Hospital Preparedness Plans
by Stephen Gibson - Wed, October 16, 2019
Transitioning from public sector emergency management for a large city to emergency management for a private sector hospital is not easy. The fundamentals of emergency preparedness are the same, but the hospital setting has unique challenges. Each day, there are different numbers of people within the hospital. Some days, the occupants exceed hospital capacity during normal operating conditions. There is no set vulnerable population as the demographics of the population changes hourly. Having a large turnover of people in the hospital because of appointments, outpatient surgeries, visitors, and vendors makes preparedness efforts more challenging.
The Early Years: Shaping a National Stockpile for Preparedness
by Greg Burel - Wed, October 09, 2019
In today's emergency response landscape, public health jurisdictions across the United States rely on the Strategic National Stockpile (SNS) when incidents prove large enough or severe enough to deplete medicines and supplies needed to protect communities. In just 20 years, the SNS – now managed by the U.S. Department of Health and Human Services' (HHS) Assistant Secretary for Preparedness and Response (ASPR) – has grown to a $7 billion enterprise poised to respond to a variety of public health threats. These threats include anthrax, botulism, smallpox, plague, tularemia and viral hemorrhagic fevers, as well as emerging infectious diseases, pandemic influenza, natural disasters, and other chemical, biological, radiological, and nuclear incidents. Although predicting the future of any program is challenging, the SNS has evolved from humble beginnings to a formidable component of national security.
Opioid Epidemic & Narcan's Unintended Consequences
by Andrew Roszak - Wed, October 02, 2019
In 2017, the U.S. Department of Health and Human Services declared a public health emergency related to the opioid crisis. Indeed, overdoses and deaths from opioids have skyrocketed over the past decade. In 2017, deaths from opioids were six times higher than in 1999. Opioids impact the quality of life and longevity, as well as have tremendous social and economic impacts on communities throughout the United States. The Centers for Disease Control and Prevention has stated that the total economic burden of prescription opioid misuse costs over $78 billion per year.
Pandemic Influenza: Advice & Suggestions From an Expert
by Andrew Roszak - Wed, August 14, 2019
With the myriad of threats that communities prepare for, influenza pandemic is consistently at the top of the priority list. In recent years, strains such as H7N9 and H1N1 have caused concern among health officials. It is no mystery why, considering the 1918 influenza pandemic – which infected over 500 million individuals around the world and caused tens of millions of deaths. Domestic Preparedness Advisor Andrew Roszak recently had the opportunity to sit down with one of the world's leading pandemic experts, Dr. Lisa Koonin. Dr. Koonin recently retired from a 30-plus year career at the U.S. Centers for Disease Control and Prevention. She was one of the leads for pandemic influenza preparedness and response efforts.
Meeting Healthcare Supply Chain Needs at All Times
by James M. Rush Sr. - Wed, May 29, 2019
The healthcare industry has numerous supply chain challenges as it strives to meet patient and facility needs during routine operations as well as during small and large surge events. The current process has gaps that need to be filled. However, there is a possible solution.
Strengthening & Streamlining Federal Response Efforts
by Greg Burel - Wed, March 20, 2019
In a world of increasingly complex and dangerous threats facing the United States – threats such as emerging infectious diseases, terrorist organizations, state actors, and extreme weather events – the Strategic National Stockpile (SNS) stands tall as a robust and reliable federal resource ready to respond. On 1 October 2018, in an effort to better align the stockpile with other federal medical countermeasure response efforts, the U.S. Department of Health and Human Services (HHS) shifted oversight and operational control of the SNS from the Centers for Disease Control and Prevention (CDC) to the HHS Assistant Secretary for Preparedness and Response (ASPR).
The Importance of Legal Preparedness for Tribal Nations
by Tina Batra Hershey - Wed, February 06, 2019
Public health emergencies, including infectious disease and natural disasters, are issues that every community faces. To address these threats, it is critical for all jurisdictions to understand how law can be used to enhance public health preparedness, as well as improve coordination and collaboration across jurisdictions. As sovereign entities, tribal nations have the authority to create their own laws and take the necessary steps to prepare for and respond to public health emergencies. Thus, legal preparedness for tribal nations is crucial to public health response.
Environmental Health – Profoundly Local & Profoundly Useful
by David Dyjack - Wed, December 12, 2018
Nutrition, community resilience, and poverty are just a few factors that are of great importance to public health professionals, which include representatives for maternal and child health, preparedness, nutrition, epidemiology, and land use planning, among others. However, the second largest segment of the public health workforce – the environmental health (EH) profession – bridges the gaps within the public health discipline as well as between public health and other disciplinary sectors.


Provides a series of functions to set and recall a new variable known as game time, as well custom tints based on current game time to give the appearance of night and day.
# appearance of night and day.
There was some.. I forgot though.
Quick question! It looks great but I does it work with RPG maker VX Ace as well?
DawningStar wrote: Quick question! It looks great but I does it work with RPG maker VX Ace as well?
This one is for Ace!
Ahh, Thank you... I had wondered that for a little bit now!
I do like ace much more than VX anyways!
Added it to my script folder!
Oh, well... I guess I should have had a notice on what RGSS versions went with what. I will fix that so everyone knows.
Anyways, great script. I have always been a huge fan of RGSS time scripts and this one just works so well. Im not sure if you are accepting any ideas/suggestions for this though, but I have some ideas floating around if you may want to take a look at them.
Either way, thank you for such a great contribution to our site.
I'll always listen to ideas and suggestions, no harm in throwing them out there.


On digging out I found this is the Virtual Centre Sever service. In order to change the database or the account settings the vcenter service should not be running. We can disable it from the following page on the webconsole of the VMware vcentre server appliance .
vCenter Server-> Status -> then click on stop vcenter.
In my case it was not working so I had to login to the console of the VMware vcentre server appliance using ssh. The login credentials are the same as root/vmware.
and it will display all the services with their status. You can verify in the next screenshot that VPXD i.e vmware-vxpd is on.
We can disable the VPXD service using the following command.
Yeah, "service vmware-vpxd stop" is working in vSphere 5.5. Thank you.


Dr suess#039;s grinch classroom door decoration bulletin, quot;oh the places we#039;re going!quot; dr seuss door decor/bulletin, door decoration ideas for children amazing decorations. Dr seuss door decorating ideas decor ideas party. Dr seuss door decoration thematic unit read across.


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Aerial overlooking the Picton Railway Viaduct, Sydney west
Uncover historical and rural charm in this scenic town on the outskirts of Sydney. Situated in the fertile Wollondilly Region, Picton is home to abundant natural beauty, railway heritage and a spectacular annual light festival. Discover native botanic gardens, historic walks and delightful streetscapes full of colonial architecture.
Your time in Picton can be as relaxed or busy as you like. Pick up a free map from the NSW Rail Museum for a self-guided historic walk of the town. Or take a scenic drive to discover the area's notable heritage architecture and beautifully restored colonial homesteads like Belgenny Farm, established by John and Elizabeth Macarthur in 1805.
The Razorback Inn, Picton
Heritage attractions include St Mark's Anglican Church, designed by the famous colonial architect Edmund Blacket – you can take an audio tour via your phone using the QR codes at the site. The picturesque sandstone Picton Railway Viaduct over Stonequarry Creek was finished in 1867. Another scenic creek crossing is Victoria Bridge, classified by the National Trust.
More railway heritage can be observed at the Mushroom Tunnel, the first railway tunnel used by NSW Railways and a beautiful example of the stone masonry of the 19th century. In the heart of Picton, you'll find Argyle Street, a quaint strip of cafes and local shops offering a range of charming gifts, treasures, ethically sourced goods, and colourful homewares and clothing.
Picton Railway Viaduct, Picton
Adventure seekers should bring their bike to explore the tranquil countryside. Start at the picturesque Picton Botanic Gardens, which has a 9km track surrounded by a selection of native Australian plants. For more outdoor fun, drive to nearby Thirlmere and visit Thirlmere Lakes National Park, where you can go bushwalking and enjoy a picnic among nature.
Sydney Skydivers, Picton
Other fun activities in Picton include go-karting, for ages seven and up, at Picton Karting Track; and the popular Sydney Skydivers, for unforgettable views over the rural countryside. Visit in May for the annual Illuminate Wollondilly Festival of Art and Light, a creative arts festival, similar to Vivid Sydney, that sees local buildings lit up as artworks are projected onto their facades.
For a slice of rural life, scope out the family-friendly Mowbray Park Farmstay to get up close to horses, alpacas, sheepdogs and the odd duck. If you prefer the finer things in life, book a luxurious weekend at The Cottage Picton.
The Cottage Picton - Credit: Photogreff/Visit Wollondilly Council
The rich, country soil around Picton supports various agricultural enterprises, which means local restaurants can use delicious seasonal produce. Country hospitality, not to mention a cold beer, is on offer at the Picton Hotel and the George IV Inn, which traces its history back to 1839.
The heritage-listed Jarvisfield House, built in the 1860s by grazier John Macquarie Antill, is now the clubhouse of the Antill Park Country Golf Club, which also has a fantastic Thai restaurant.
George IV Inn, Picton
Picton is around an hour's drive southwest of Sydney's city centre and 45min northwest of Wollongong. Or you can travel by train from Sydney.
Sydney Skydivers
Sydney Skydivers is Sydney's only self contained skydiving centre and Australia's largest skydive training centre.
Picton Karting Track
Push the pedal to the metal, full acceleration, green lights and you're on your way to an extreme adrenaline rush on four…
Picton Railway Viaduct
The Viaduct is a heritage-listed railway over Stonequarry Creek in Picton. The sandstone structure was built between 1863…
Mowbray Park FarmStay
Mowbray Park Farmstay is the closest working Farm Stay to Sydney. The property has been family owned and operated since the…
Picton Botanic Gardens
Take a relaxing break in these picturesque surrounding with many walking tracks and cycling trails.
Escape to the country with a farmstay family getaway
Six reasons why Sydney should be your next family holiday
Places to visit in Sydney West
Thirlmere
AccommodationEventsActivities


This white wine is grown in the Pegoes region, a jurassic seabed that makes up the sun-baked plains east of Lisbon, are renowned for their scented bouquet and fruity flavor. This wine is an aromatic medley of rich and juicy summer-ripe fruit, yet is refreshingly zesty, crisp and dry. Great with Asian and spicy cuisine, and of course seafood. Serve really cold.


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del .\*.nupkg
nuget.exe pack .\project.json -IncludeReference -Prop Configuration=Release

redpajama_set_name: RedPajamaGithub


Since 1996 online first. For his clients Oliver Frank is used to analyse, centralize and streamline digital marketing campaigns across all online-channels on multidevice, and achieve fully customizable insights through their proprietary reporting layer. He helps clients to create, launch and manage integrated campaigns efficiently. His work experience: Goldbach, MEC, TBWA\, Axel Springer, DQ&A and Gamned!


Food, isn't that the first thing you worry about when you are travelling with kids? It is good to know what your best bets are in foreign land, especially in food. Familiarity always helps us settle in, so go ahead and know the country even before you visit it.
Let me take you to the land of elephants, beaches and all things Thai. Personally Thailand knows me well by now, from Chiang Mai to Krabi to Hua Hin, we are close family friends, you know. The flavourful Thai food helped us break the ice. Years ago, devouring food at this wonderful place at the Bangkok Swarnabhumi Airport, I discovered the fiery green pepper, Thai ginger, lemongrass and the comfort food of all Thai people – fried rice. In fact our kids had a feast in Thailand thanks to chicken satay, noodles and yes, FRIED RICE.
This dish is a wonderful window to the Thai culture. How you ask? Well in Thailand, there is no state religion. Although the King (the highest authority in Thailand) is required by law to be a Buddhist, the people are free to practice any religion of their choice – Hinduism, Islam, Christianity and so on. What's more this nation that borders Burma, Cambodia, Malaysia and Laos has some 75 ethnic groups. All of them live harmoniously and bring their own flavours and colours to this song-and-dance loving country.
Similarly in fried rice, different sauces, vegetables, seafood and meat comes together to celebrate health and taste. Depending on whether you are in the coastal area or the hills in Thailand, what you add to your fried rice may vary – chicken, crab meat, prawns, fish and a lot more. But the love and easy availability of it stays the same. The Thai people like dressing up in bright colours and have a soft corner for nature, parks and gardens. Likewise any well made fried rice will always be dressed in greens, yellows and oranges, and will smell of nature. Why don't we cook up this riots of colour and taste ourselves? Here is my easy recipe to this quick and healthy dish.
Step 1: Heat olive oil in a wok, add ginger, garlic and onions and stir fry for 30 sec.
Step 2: Add chicken and the sliced vegetables except peas and fry at high heat till chicken is cooked. The vegetables need to stay crisp though.
Step 3: Push the veg. and chicken mixture to one side of the wok and in a tsp of oil make scrambled egg. Mix everything.
Step 4: Add peas. Immediately add soy sauce and vinegar to the mixture.
Every time I make Thai fried rice at home, my kids eat a bowl full of it, smiling all the way. As a mother I am happy that a week's quota of veggies have entered their system. More importantly while discovering Thailand, I was at peace that they were eating something other than french fries and chocolate shakes.
I hope we have got you intrigued about Thailand because next week a special guest is visiting KetchupMoms all the way from Thailand with some irresistible Thai recipes coming your way. We're excited for sure!
This simple direction to make Thai Fried Rice is very welcome. I have tried so many versions but have never tried Thai version of fried rice. Looks yummy!
Thank you Vikram Hope you cook it soon and enjoy it with some great wine.


New Standards for Hard Drive Destruction?
Note that Levels 1-3 are about damaging drives. Levels 4-7 are maximum shred sizes.
Although the DIN standards may be helpful in the commercial world, they will have no standing in the classified world. Classified magnetic (rotational) drives will still need to be degaussed using a National Security Agency (NSA) listed degausser. Once the information is destroyed by degaussing, you can decide what further procedures you want to employ to secure your drives. The only guidance the NSA provides is that it is highly recommended that drives be further damaged. This is noted in the agency's Storage Device declassification Manual (SDDM). What this means is that as a Security or IT Manager, you have the discretion to decide what method best fits your organization. That's why there are a wide range of methods available to damage your drives.
If your volume is modest or your application tactical, punching drives after degaussing may be the best option. Punching is the most popular destruction method. The equipment takes less space and is less expensive. Automatic models are available that plug into a standard 115 volt outlet with a 10 second cycle. The better ones will punch out the whole spindle and damage each drive platter. Manual models are available that require no power but your own.
Believe it or not, Hard-drives can be shredded in modest volumes with an office model using a dedicated 115 volt outlet. Heavier volumes (more than 250 per week) can be handled by some of the more powerful three-phase models available. You can also choose from many shred sizes. We offer 1.5", 1", and ¾" shred sizes in our standard models.
These new standards are not relevant for the destruction of classified Solid State Drives either. The NSA policy (SDDM) for SSDs is that you should "…disintegrate into particles that are nominally 2 millimeter edge length in size using an NSA/ CSS evaluated Disintegrator…" Even if a product could shred to the new Level 7 standard, it would not meet the requirement. Level 7 is close, but not quite small enough.
To summarize, you may see these Level 1-7 standards mentioned in coming years. Standards like this are good and needed in the corporate world. Just understand they have no standing in the classified world.


Find great deals on eBay for pvc garden fence panels and plastic fence panels. Shop with confidence.
Find great deals on eBay for pvc garden fencing and pvc garden screening. Shop with confidence.
Fiberon composite and PVC decking. ... Fencing Decking Ideas. Product Gallery ... Exceptional outdoor living for every taste and budget.
Barrette Outdoor Living is one of the largest manufacturers of fencing, railing and outdoor living products in the USA.


Showing 3,036 homes around 20 miles.
Recently Sold Homes in 30757 have a median listing price of $140,750 and a price per square foot of $104. There are 7 active recently sold homes in 30757, which spend an average of days on the market. Some of the hottest neighborhoods near 30757 are Downtown Chattanooga, Martin Luther King, Piney Woods, Cedar Hill, Oak Hill. You may also be interested in recently sold homes in popular zip codes like 30752, 30738, or in neighboring cities, such as Wildwood, Chattanooga, Trenton, Rising Fawn, Ringgold.


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Q: RequiredFieldValidator in Asp.net Any One Can Help.....please
I am Doing In microsoft visual studio 2010,ajax validation callout extender ,Asp.net RequiredFieldValidator i am using in my Page....
I am Using RequiredFieldValidator In All My Text Boxes When i Am My Mouse Leaving The Test Box(Empty)
My RequiredFieldValidator Is Not Coming IF i Click Submit Button Only The RequiredFieldValidator are Coming So Can Any One Help
And I want a regular expression it Must Have Both Characters and Numbers
Ex:100gb,20kb,like this Number and units of Space,Band width,Sub Domain(right)
100(Error Have to come)
gd(Error Have to come)
please Help Only using Asp.net And Ajax

A: Declare a ValidationGroup on the validation controls and the button click.
the regular expression off the top of my head could be ^((\d{2,3})([\w{2}]))$
This based on what I can make of your question and the information supplied


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Home/About/Historic Photos
Historic Photos2020-11-09T16:03:49-05:00
Photos from Baltimore County Public Library
Portion of George Washington Bromley's 1898 Atlas of Baltimore County, Maryland, Plate 22: Parts of the 9th and 11th districts showing the Aigburth area of Towson which included the present-day communities of Aigburth Manor, Burkleigh Square, Towson Manor Village, and Knollwood/Donnybrook.
Aigburth Vale, a Second Empire style mansion built by Niernsee and Neilson (c. 1868) as a country home for wealthy actor John E. Owens. Adjacent to the Towson Senior High School property, the building was eventually purchased by the Baltimore County School Board for offices. In the 1990's, the Board of Education returned the property to the County and it was offered for sale. Aigburth Vale is on the Baltimore County Landmarks list, and is currently senior apartments.
This 1925 aerial view looks west over part of the Towson Nurseries estate towards Stephens Hall and Newell Hall of the State Normal School (Towson University). Towson Nurseries plantings are on the east side of York Road, off what is now Cedar Avenue. The Stone-McCabe house (now the Newman Center) is in the middle distance, and the Judge Nicholas Burke house on Burke Avenue is slightly to the south and right of the Newell Hall residence building.
#1 Terracedale, c. 1917. Photo taken facing east from across York Road. The Thomas house on the left was razed before 1960 and the site is now the southern end of the York at Terracedale office building.


There are schools offering mechanical engineering degrees in Idaho!
Each year, roughly 0.6% of Idaho students graduate with degrees in mechanical engineering. Thus, Idaho's 7 mechanical engineering schools put out approximately 216 mechanical engineers each year.
The top-ranked school in Idaho with a mechanical engineering program is University of Idaho, which is located in Moscow. In 2010, it was ranked 34th nationwide. In 2010, University of Idaho graduated 83 students from its mechanical engineering program. The tuition rate at University of Idaho was $5,402 per year.
The second-ranked school in Idaho with a mechanical engineering program is Boise State University, which is located in Boise. In 2010, it was ranked 42nd nationwide. 36 students graduated with degree in mechanical engineering from Boise State University in 2010. The tuition rate at Boise State University was $5,300 per year.
The third-ranked school in Idaho that has a mechanical engineering program is Brigham Young University-Idaho. Brigham Young University-Idaho, which was ranked 68th in the country in 2010, is located in Rexburg. In 2010, Brigham Young University-Idaho graduated 80 students from its mechanical engineering programs. The tuition rate at Brigham Young University-Idaho was $3,660 per year.
A mechanical engineering degree from an Idaho school... what next?
According the US Bureau of Labor Statistics the number of mechanical engineers is expected to grow by 4% by 2018. There are projected to be 1,470 mechanical engineers working in the Idaho then.
Take a look at the graphs and charts below for additional Idaho statistics regarding a career in mechanical engineering and to compare salaries with a variety of related fields such as civil engineering or mechanical engineering.


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Факултет "Компютърни системи и технологии" (съкратено ФКСТ) е основно учебно звено в Техническия университет в София (ТУС).

История
Обучението по компютърно инженерство в ТУС води своето начало от 1960-те години. Във Факултета по радиоелектроника (основан през 1963 г.) на Висшия машиностроителен институт (съкр. ВМЕИ; днес: Технически университет) в София е въведена специализация "Изчислителни машини и устройства" към специалността "Електроника". През 1969 г. във факултета е създадена Катедра "Изчислителна техника", която започва обучение по едноименна специалност.

Освен обучение по специалностите "Електроника" и "Изчислителна техника", факултетът води също обучение на студенти по "Радиотехника" и "Съобщителна техника". През 1987 г. с решение на Министерския съвет от факултета са формирани 2 нови: Факултет по електронна техника и технологии (ФЕТТ) и Факултет по комуникационна техника. Катедра "Изчислителна техника" е в състава на ФЕТТ.

На 1 април 1984 г. със заповед на Министерството на народната просвета се открива катедра "Програмиране и използване на изчислителни системи" (ПИИС) към Изчислителния център на ВМЕИ в София. През 1989 г. Катедра "Изчислителна техника" преминава към новосформирания Факултет по компютърни системи и управление (ФКСУ).

В средата на 1990-те години катедра "Изчислителна техника" се преименува на "Компютърни системи", а катедра ПИИС преминава към ФКСУ и се преименува на катедра "Програмиране и компютърни технологии". Катедра "Информационни технологии в индустрията" във ФКСУ е създадена през 2015 г.

Факултетът сменя своето име на "Компютърни системи и технологии" през 2017 г.

Декани
 от 1987 до 1989 – доц. к.т.н. Иван Стойчев
 от 1989 до 1991 – проф. д.т.н. Димо Арнаудов
 от 1991 до 1995 – проф. д.т.н. Стойчо Стойчев
 от 1996 до 2003 – доц. д-р Хуго Оскар
 от 2003 до 2007 – доц. д-р Ангел Ангелов
 от 2007 до 2015 – проф. д-р Огнян Наков
 от 2015 до 2019 – проф. д-р Даниела Гоцева
 от 2019 г. – проф. д-р Огнян Наков

Структура
Факултетът включва 3 катедри:
 Катедра "Компютърни системи", създадена като Катедра "Изчислителна техника" през 1969 г.
 Катедра "Програмиране и компютърни технологии", създадена като Катедра "Програмиране и използване на изчислителни системи" през 1984 г.
 Катедра "Информационни технологии в индустрията", създадена през 2015 г.

Ръководители на Катедра "Компютърни системи"
 от 1969 до 1992 – проф. д.т.н. Борис Боровски
 от 1992 до 1996 – проф. д.т.н. Боян Янков
 от 1996 до 2000 – доц. д-р Васил Василев
 от 2000 до 2004 – проф. д-р Ради Романски
 от 2004 до 2015 – проф. д-р Пламенка Боровска
 от 2015 г. – проф. д-р Милена Лазарова

Ръководители на Катедра "Програмиране и компютърни технологии"
 от 1984 до 1992 – доц. д-р Денчо Батанов
 от 1992 до 2000 – доц. д-р Иван Момчилов Момчев
 от 2000 до 2004 – доц. д-р Стоян Богданов Малешков
 от 2004 до 2007 – проф. д-р Гочо Гочев
 от 2007 до 2008 – доц. д-р Юлиана Георгиева
 от 2008 до 2015 – доц. д-р Мариана Горанова
 от 2015 г. – доц. д-р Димитър Божков

Ръководители на Катедра "Информационни технологии в индустрията"
 от 2015 г. – проф. д-р Румен Трифонов

Други видни учени, работили във факултета
 проф. дтн Людмил Даковски
 проф. дтн Иван Табаков
 доц. д-р Ангел Попов
 проф. д-р Никола Касабов

Външни препратки
 Факултет Компютърни системи и технологии
 Катедра "Компютърни системи"
 Катедра "Програмиране и компютърни технологии"
 Катедра "Информационни технологии в индустрията"

Бележки

Компютърни системи и технологии


Provides data for the ASPxPivotGrid.CustomGroupInterval event.
This example shows how to provide a custom criteria used to group axis values. The Custom Group Intervals feature is used to group product names and make the report more readable. The Product axis will show three intervals ("A-J", "K-S" and "T-Z").
The 'Products' field's DevExpress.XtraPivotGrid.PivotGridFieldBase.GroupInterval property is set to Custom at design-time. The grouping logic is implemented within the ASPxPivotGrid.CustomGroupInterval event handler.


text:
Th2 cytokines-DUOX2-ROS-HMGB1 translocation axis is important in the pathogenesis of allergic rhinitis.
Min HJ
Min HJ(1), Park JS(1), Kim KS(1), Park SY(1), Choi H(2), Seo JH(3)(4), Kang M(3)(4), Yoon JH(3)(4), Kim CH(3)(4), Kim S(5)(6), Cho HJ(3)(4).
(1)Department of Otorhinolaryngology-Head and Neck Surgery, Chung-Ang University College of Medicine, Seoul, Republic of Korea.
(2)Division of Chemical Engineering, Konkuk University, Seoul, Republic of Korea.
(3)The Airway Mucus Institute, Yonsei University College of Medicine, Seoul, Republic of Korea.
(4)Department of Otorhinolaryngology, Yonsei University College of Medicine, Seoul, Republic of Korea.
(5)Center for Theragnosis, Korea Institute of Science and Technology, Seoul, Republic of Korea.
(6)KU-KIST Graduate School of Converging Science and Technology, Korea University, Seoul, Republic of Korea.
https://dx.doi.org/10.1042/CS20201212
The function of high-mobility group box 1 (HMGB1) varies according to its location. However, the translocation mechanism behind HMGB1 remains unclear. We hypothesize that type 2 helper T cell (Th2) cytokines are involved in the translocation of HMGB1 in the upper airway epithelium. We investigated the mechanism behind HMGB1 translocation using Th2 cytokine stimulation and examined the clinical significance of HMGB1 translocation in allergic rhinitis (AR). Cytoplasmic and extracellular HMGB1 were increased in AR. Inhibiting HMGB1 translocation with glycyrrhizic acid (GA) decreased the level of antigen-specific immunoglobulin E (IgE), the degree of Periodic Acid-Schiff (PAS), and Sirius Red staining in the murine model. The in vivo reactive oxygen species (ROS) level in the nasal mucosa was higher in the mice with AR than in the controls. Th2 cytokine-induced up-regulation of the ROS and translocation of HMGB1 by Th2 cytokines was dependent on the generated ROS. The ROS level also increased in the murine model. We suggest that the Th2 cytokine-dual oxidase (DUOX)2-ROS-HMGB1 translocation axis is important in AR pathogenesis.
Neighborhood environment, social cohesion, and epigenetic aging.
Detection of gene cis-regulatory element perturbations in single-cell transcriptomes.