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Bundeena House by Tribe Studio Architects - Dwell
2022-04-07 03:10:04 By : Ms. Susan Su
This weekend home south of Sydney is more than just an escape for architect Hannah Tribe and her family. Situated at the edge of Royal National Park in the beachside hamlet of Bundeena, the design by Hannah, principal and founder of Tribe Studio Architects, is also a prototype for a new kind of kit home.
Architect Hannah Tribe designed her family's holiday home—a nod to the fisher cottages in the area—using prefab technologies. "We moved away from modular," explains Hannah, "because New South Wales has steep, windy roads which can make modular tricky, and kit construction provides opportunities for more local labor, supporting regional communities."
Looking at it from the street, the roughly 540-square-foot design presents itself modestly enough. Its minimalist timber-clad exterior nods to local vernacular, keeping with fishing cottages prevalent in the region that stand in large gardens with their rectilinear forms. Hannah's innovations—and this is where the Bundeena home parts ways with the buildings of yore—are primarily concerned with economy of materials, energy efficiency, and sustainability, which allow the design to be replicated affordably and with ease in a variety of settings.
Everything relies on a "strict mathematic logic," says Hannah. Although she doesn't dive into the numbers, the design starts with a concrete slab, and a modular timber frame that rises roughly 17 feet without the support of structural steel. Hannah could have expanded the home's tight footprint and added a second level to capture water views, but that would have betrayed the area's aesthetics.
The family-friendly design can host up to 12 people and is sturdy enough to withstand "salt and sand," says Hannah.
It doesn't take much to heat the entire home, but on chillier days, a French Philippe Chemise fireplace does the trick.
"This house is a retreat from busy city lives that encourages a slower way of living by the beach," explains Hannah. "It is a garden- and cooking-focused holiday home and a place where children and adults are connected." The painting is by Australian artist Gemma Smith.
The open kitchen is perfect for Hannah and her family, who love cooking for crowds.
"We could have had glorious views from a second story," Hannah explains. "However, we felt that reinforcing the local vernacular of single story timber cottages was important, and that an introspective garden diagram was preferable to outward looking in this context."
A second level would have also worked against Hannah's initial concept, she says. And with a single level, it meant she could focus on energy efficiency.
The electric-blue dining chairs are vintage school chairs sourced by Hannah. The rounded pendant light hanging over the dining table is by Muuto and the sculptural wall lighting is Le Corbusier's Nemo.
The U-shaped floor plan wraps around a sunny central courtyard.
Hannah engaged landscape architect Christopher Owen to enhance the garden. His plan fosters native and endemic species that attract bird life, including kookaburras, tawny frogmouths, cockatoos, fairy wrens, and sea eagles.
Passive heating and cooling are achieved through the thermal mass of the concrete slab, and by siting the house to allow breezes to flow through its floor-to-ceiling sliders. Windows facing east, north, and west feature adjustable shading to reduce solar gain, while ceiling fans in the bedrooms provide a little extra airflow. All windows are double glazed, and the walls, although lightweight, are heavily insulated.
An extensive 5-kW photovoltaic array attached to the roof provides energy to the home, while a rainwater recycling system harvests water for the bathrooms, washing machine, and a garden irrigation system.
Hannah also made an effort to choose recycled materials and plantation timbers, and low- or no-VOC paints and finishes. The home's water is heated with solar, and energy-efficient LED lighting runs throughout.
One of the adult bedrooms opens to the courtyard.
Awnings positioned over north-facing windows reduce solar gain, so there's no need for air conditioning. Ceiling fans provide light airflow in the bedrooms.
In plan, the U-shaped home wraps around a sunny central courtyard that faces a rear garden to the north. Inside are two adult bedrooms, and a kids' room with beds and built-in sofas can sleep up to six. Instead of a mudroom, a laundry-and-bathroom combo in the entry is "a deliberate sand trap" for beach towels, wetsuits, and shoes—an appropriate substitute given the home is sited just 350 feet from the beach.
The bathroom features a skylight and rose-colored terrazzo.
One of the kids' rooms features built-in shelving.
All in, the family-friendly design can host 12 people, "including lots of kids and dogs," says Hannah. The home's full-height doors create an indoor/outdoor connection between the garden, the living spaces, and the interior courtyard. It's also designed to be sturdy enough to accommodate the family's sporty leisure activities, and "to withstand the salt and sand," as Hannah puts it. "[We do] lots of swimming and paddle boarding and kayaking and walking in the bush."
By putting the home on a slab, Hannah has created a stepless design, allowing her to eventually age in place or accommodate guests with limited mobility. "This house is an attempt to achieve a high level of architectural and sustainable outcomes at a low cost," says Hannah. "It is an experiment in delivering a more thoughtful kit home."
An external wall frames a beautiful existing Queensland bottle tree.
An outdoor shower allows everyone to rinse off alfresco after a long day at the beach.
More from Tribe Studio Architects:
This 1930s Home in Sydney Was Preserved in the Front and Updated in the Back
Architect of Record: Tribe Studio Architects / @tribestudio_
Builder/General Contractor: Ballast Construction + George Payne
Landscaping: Christopher Owen / @christopher_owen_
Artwork: Gemma Smith
From cozy cottages to large family houses, see how prefab continues to redefine the future of construction, building, and design.
© 2022 Dwell Life, Inc. All rights reserved.
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UK Court Sends Retailer/Credit Card Fee Fight To Competition Tribunal
Posted on July 5, 2018 July 4, 2018 12:49 pm
The U.K.'s Court of Appeal ruled Wednesday (July 4) that a fight between U.K. retailers and credit card companies over fees has to be reexamined by a competition tribunal.
The Financial Times, citing court proceedings, reported that Asda, J Sainsbury and Wm Morrison's claims against Visa and Mastercard will be decided by three senior judges. The retailers are appealing three separate cases that the judges would rule on, noted the report. The legal fight has to do with interchange fees, which are the costs businesses pay for processing credit card payments. The fee is charged every time a credit card is used by the consumer. The retailers contend the amount of interchange fees at Mastercard and Visa run afoul of the restriction of competition law. The outcome could impact other lawsuits Mastercard and Visa are facing over interchange fees, noted the Financial Times. The Court of Appeal said it was planning to send the three cases back to the Competition Appeal Tribunal (CAT) for reconsideration.
The CAT can neither retry the cases nor hear new evidence, but it can assess damages and decide if exemptions should be applied to the credit card companies. The High Court judge will chair the review, reported the Financial Times. The three cases were sent to the Court of Appeals after differing rulings by judges in lower courts, noted the report. In 2016 the Competition Appeal Tribunal ordered Mastercard to pay £68.5m in damages to Sainsbury. The tribunal ruled Mastercard broke European Union and U.K. competition laws regarding interchange fees. Sainsbury has also claimed damages because of the level of interchange fees. Visa, on the flip side, won a case against Sainsbury with the High Court finding the U.K. fees did not break the competition laws.
In a statement to the Financial Times, Mastercard said, "We continue to firmly believe that retailers derive real value from our network and we are committed to helping our retail partners grow their businesses and encourage the adoption of ever more convenient, safe and secure payments." Visa declined to comment in the report. Meanwhile, J Sainsbury said in a statement: "We are pleased with the Court of Appeal's declaration that both Mastercard and Visa's domestic interchange fees are restrictive of competition. We will consider the judgment carefully and remain confident in the next hearing at the Competition Appeal Tribunal which will examine whether there is any lawful level of interchange fee for either scheme and establish our damages."
Related Items:asda, courts, credit card fees, Interchange Fees, MasterCard, News, retailers, Sainsbury, uk, Visa, What's Hot
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redpajama_set_name: RedPajamaCommonCrawl


St. Paul Lutheran Church welcomes Rev. Dr. Ryan Petersen, Concordia University, Ann Arbor. He will preach all weekend services, February 2-3. Also, please join us in the sanctuary, 9:50-10:45am where Pastor Petersen will facilitate our Bible Class Hour. A special invite to our youth, high school students, and parents. Some may remember his previous visit a few years ago when preached and met with our high school students and well received by all.


The GPS navigator systems is very helpful for driver but how to choose the gps systems that is suitable for us? In this article will tell you the method to buy the best gps systems for your cars.
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There are a lot of people who wish to trade within the Foreign Exchange or the commonly known as Forex market, but do not have time to keep an eye on the market for twenty four hours a day. If you are such trader, then using a managed Forex trading account maybe suitable for you as it can often turn out to be the best forex trading investment.
In every investment that you make, you would always want to gain from it. Nobody would want to experience losses when trading, especially if you are trading in international markets like the Foreign Exchange market. A lot of people have invested in Foreign Exchange trading in order to have the opportunity to be able to make a substantial profit.
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Puente Gasset fue un puente en la ciudad de Burgos (Castilla y León, España).

Historia
Las obras fueron iniciadas en 1924, siendo los ingenieros de la División Hidráulica del Duero los que más aportaron en la decisión del diseño final del puente, participando de manera directa Virgilio García Antón.

La obra fue adjudicada al contratista Alberto Corral con un valor de 215.574 pesetas.

La inauguración del puente se dio el 3 de marzo de 1926, a la cual se invitó a gran parte de las autoridades locales y a gran parte de los delegados de los ministerios. Una procesión cívico-religiosa fue organizada, la cual partió de la iglesia de San Lesmes. También fue instalada una tribuna en el Paseo de la Quinta, adornada con gallardetes y banderas, desde donde se pronunciaron los discursos institucionales donde intervino el alcalde, por aquel entonces Ricardo Amézaga y el director general de obras públicas, Rodolfo Gelabert. Los actos terminaron con un banquete oficial.

Las primeras reformas se dieron en 1928 cuando se colocaron 4 farolas.

En 1934 se construyeron sus aceras, y en 1944 se realizaron importantes mejoras en el entorno ya que se pavimentaron los accesos al puente.

Las décadas siguientes sufrieron pocas mejoras y el puente sufrió gran deterioro, es por ello que en el año 2000 se planteó la posibilidad de realizar una reforma general pero la obra quedó paralizada. En 2005 comenzó a plantearse la idea de aumentar las dimensiones del puente. Esto se llevó a cabo en 2009 cuando David Hernández sostuvo que el puente se iba a cambiar por uno de mayor capacidad. Ese mismo año, el informe previo a la ejecución de la reforma sostenía que el puente constaba de graves problemas estructurales.

En mayo del 2010 se iniciaron los derribos junto con su reconstrucción.
En 2011 fue terminado, siendo apodado como el Puente de la Evolución, estando junto al Museo de la Evolución Humana y añadiéndose a sí mismo a la lista de los Puentes de Burgos.

De qué está hecho
El puente en sus inicios estaba formado por cinco vanos isostáticos, estos, formados por vigas de hormigón armado y apoyados sobre dos estribos y cuatro pilares intermedios.
Después de la reforma realizada en 2010 el resultado fue una singular estructura de hormigón con tres vanos, dos pilas con tablero posteado empotrado, y tres pilares de apoyo. El tablero presenta unos perfiles curvos que le dan una gran movilidad junto con una gran complejidad visual.

Referencias externas
Puentes de Burgos, escrito por Pedro Hombría, Gonzalo Andrés, Lena Saladina, María José, René Jesús y Ángel Moreno.

https://burgos.callejero.net/calle-del-puente-gasset.html

Puentes de Burgos

redpajama_set_name: RedPajamaWikipedia


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Mountain Statesman
Hazel "Suzie" Lee Cool
By: Davis Funeral Home - Updated: 1 month ago
Hazel "Suzie" Lee Cool, 76, of Shadyside, Ohio passed away on Wednesday, December 9, 2020 at Forrest Hill Continuing Care.
She was born on January 16, 1944 in Clarksburg, daughter of the late Harry Goff and Hazel Pauline Thompson Plaugher.
Suzie graduated from Victory High School in Clarksburg and then attended WVU, where she graduated with her degree in nursing. She worked as an LPN at UP Hospital in Clarksburg and Grafton City Hospital for many years. Suzie married her husband, Lawrence "Larry" "Bink" Cool, on July 28, 1977. Suzie enjoyed making blankets, cooking, and bingo. She was a member of the Church of Christ in Shadyside, Ohio.
In addition to her husband, Suzie is survived by her children, David Lee Kidd, Morgantown, Danny Kidd, Moundsville, Bo Kidd and wife, Jennifer, and Donna Rice, all of Shadyside, Ohio, and Danyell Martin and husband, Gary, Ohio; grandchildren, Allison, Holly, Justin, Ryan, Shannon, Kayla, Tyler, Josh, Madison, Marshall, Henry, and Emily; several great grandchildren, nieces, and nephews.
In addition to her parents, Suzie was preceded in death by two sisters, Betty Hurst and Janet Martin; and three brothers, Harold, Carl, and Gayle Plaugher.
Family will receive friends at Shadyside Church of Christ, 3821 Leona Street Shadyside, OH, on Sunday, December 13, 2020 from 2:00- 4:00 PM, with proper distancing and face mask required.
Family will receive friends at Davis Funeral Home, 124 Olen Thomas Drive Clarksburg, WV, on Monday, December 14, 2020 from 9:00 AM, until the time of the funeral service at 12:00 PM, with Reverend Richard Settles officiating.
Interment will follow at the West Virginia National Cemetery in Grafton, WV.
Davis Funeral Home is honored to assist the Cool family.
Online condolences may be sent to DavisFuneralHomeWV.com.
Charlie David Digman
Donald Dewayne Bowman
Eleanor Ruth Burton
Kirk S. Sparks
914 W. Main St Grafton WV 26354


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Capistrano Teacher Union Operative's Story Hard to Swallow
Deceptive campaign websites point to CUEA front-group leader.
The Capistrano Unified School District (CUSD) in California's Orange County has seen more than its share of school board battles in recent years. In 2008, parent activists managed to rid themselves of possibly the most corrupt school board in America. Immortalized in Not As Good As You Think, parents endured the horrors of an enemies list, publicly-released home phone numbers and implied threats against their children, but remained determined and ultimately managed to seat a reform-minded, honest, child-friendly board.
The peace that returned to this upscale area was short-lived, however. In January 2010, a recall against two of the board members was launched. The Capistrano United Education Association (a California Teachers Association local) didn't think much of Mike Winsten's and Ken Lopez-Maddox's emphasis on children, their refusal to kowtow to CUEA and their conservative leanings. Leading the charge was the Orwellian-named Children First,a CUEA front group, whose agenda couldn't find room for kids.
Unfortunately the union's efforts to recall Winsten and Maddox-Ford were successful. At the same time, three other board members were up for reelection. After the dust had settled on Election Day, 2010, the board consisted of four pro-children and three pro-union members. CUEA seemed pleased, though its spending binge did not secure the union a majority. According to the Orange County Register,
Capistrano Unified's teachers union has poured $261,863 into the district's school board election to date (Oct. 30), including $67,040 this week alone, while its chief political rival, the Committee to Reform CUSD, has continued to lag behind, reporting no spending over $1,000 in the past two weeks.
With spending by the union's ally – the Capistrano Unified Children First group – factored in, overall spending by these groups is outpacing the Reform Committee's spending by more than a 16 to 1 margin.
And once again, it's school board election season for CUSD and, not surprisingly, union spending is going gangbusters. For the most part, the reformers are putting their own money into their campaigns, but the union-backed candidates – surprise, surprise – are getting a big financial boost from union front groups. According to local writer Penny Arévalo,
The two biggest money raisers and spenders are the teachers' union PAC, known as Help Organize for Public Education, and a group that rallies for similar candidates and causes, Capistrano Unified Children First.
Children First has raised $36,537 and spent $32,485. It has a cash balance of $5,816.
HOPE has raised $73,228 this year and spent $26,097. It's sitting on $67,805.
But it seems that providing its candidates with a huge spending advantage isn't enough for the union and its acolytes. Apparently, someone closely associated with CUEA set up a series of fraudulent websites. Particularly hard hit was Julie Collier, leader of a group called the Parents Advocate League. Collier has made some enemies because she has the temerity to believe that parents should be informed about educational issues that pertain to their children. Two of the bogus websites targeted her – one using her own name and the other using her organization's name. Furious, Collier immediately retained a lawyer to find the culprit, and on October 17th, Arévalo reported "Deceptive Campaign Websites Tied to Children First Volunteer."
In a letter sent to attorney Wayne Tate by GoDaddy, which hosted at least six misleading URLS, Chris Korpi was identified as the person who bought www.juliecollier.com and www.parentsadvocateleague.com, which initially redirected visitors to school board President Gary Pritchard's campaign site and Children First's website, respectively.
A GoDaddy representative said the company cannot confirm whether the person who supplied all the information to purchase the domain names was indeed Chris Korpi.
Seemingly Korpi, the man behind Children First – the union front group – has been caught with his fingerprints all over the cookie jar, though he adamantly denies the charges.
Korpi blamed the misleading web addresses on political opponents, noting he hasn't run the business named in the GoDaddy email, Korpi Marketing Services, for eight years, and that all his contact information listed is publicly available for someone to steal his identity.
Grasping at straws, he even had the temerity to blame the dirty tricks on Jennifer Beall, who along with her husband Rancho Santa Margarita Mayor Tony Beall, are long time CUSD reformers. The Bealls and Collier are allies, and to blame Beall for the misdeed is positively loony.
And I guess it's just a coincidence that, according to Arévalo, Korpi is on the payroll of John Alpay, a union-backed incumbent running for reelection.
One of the misleading URLs went to Alpay's campaign site. He and (incumbent Gary) Pritchard are both endorsed by Children First
This would all be humorous – great fodder for The Onion or Saturday Night Live – if it weren't dealing with real kids, their real parents and their very real problems with education in their school district. Whether the guilty party is Korpi or some other union crony, it is apparent that that CUEA will stop at nothing in its quest for power. And there is nothing at all funny about that
Posted in Education | Leave a Comment »
Tags: Capistrano Unified Education Association, Capistrano Unified School District, Children First, Julie Collier, Not as Good as You Think, Parents Advocate League
The Results of Obama's Hope and Change
Those that voted for Obama did not realize that when you voted for Hope & Change you were voting for the hope that he would leave you with some change… in your pocket. How did that work out for you?
Unemployment still in double digits and worsening
80% of college grads cannot find work in chosen profession
Over 40% of Americans now on federal assistance (an all-time high)
National debt UP 60% since taking office (over $16 trillion)
An 84% failure rate on "green" taxpayer investments that most taxpayers opposed
Average American income DOWN over $4000 per year
Home values still DOWN more than 30% nationally
Businesses are closing and investors are leaving America
Obama has sent more jobs overseas than all of the last five presidents combined
Inflation is the most punishing tax of all – printing and borrowing 42 cents for every dollar the government spends is suicidal.
Cost of gas UP 137%
Cost of potatoes UP 306%
Cost of butter and coffee UP more than 150%
Beef, milk and flour UP more than 100%
Eggs and rice UP over 70%
Posted in Big Government, Crime & Corruption, Politics | 2 Comments »
Workers and the Job Creators « The USA Plan
Since the beginning of time no government has ever has ever allowed their workers to achieve financial independence. They have never legislated a way to do that. In 1776 that limitation was partially lifted. America created the world's first democracy and introduced the opportunity for anyone to become financially independent. That opportunity created a new class of people called job creators.
No history lesson is needed here. A free market society naturally pits the job creator against the worker. The cost of workers affects the bottom line of the job creator therefore his shareholders, bankers, creditors look to him to keep the cost of workers as low as possible to maintain his profitability and stability. This has naturally created class warfare between the job creators many of whom have achieved financial independence and workers who mostly haven't.
Today a great debate is going on in America about everything except the real missing link – how to help workers achieve financial independence. Everyone is too busy just surviving shrinking income and wealth, joblessness and economic stagnation. Everyone is screaming at each other about which political party has a plan to just get America back on a stable and sustainable economic path and create millions of jobs. Continue reading via Workers and the Job Creators « The USA Plan.
Posted in Big Government, Crime & Corruption, Economics | Leave a Comment »
Los Angeles County MOBILE PHONE VOTER GUIDE
MOBILE PHONE VOTER GUIDE
Data complied from Craig Huey's Blog
BRING THIS GUIDE WITH YOU TO THE VOTING BOOTH.
IT IS LEGAL to use your smart phone for reference in the voting booth.
President – Mitt Romney
U.S. Senator – Elizabeth Emken
State Propositions
30 NO – Tax Hike.
31 NO – Constitutional Amendment.
32 YES – Stop Political Contributions by Payroll Deduction.
33 YES – Car Insurance Based on Driver History
34 NO – Repeal Death Penalty
35 YES – Stop Human trafficking is
36 NO – Gutting three strikes…
37 NO – Food Labeling "Right to Know"
38 NO – Tax Hike Light
39 NO – Green Tax
40 YES – Redistricting
Measure P NO – Bond
Measure Q NO – Big Bucks for Politicians
Measure R NO – Cut Salaries for Supervisors
Los Angeles County (Congress, State Senate, Assembly, City, Special District and School)
United States Representative; District 23
Kevin McCarthy, Republican
Howard P. "Buck" McKeon, Republican
Tony Strickland, Republican
Jack Orswell, Republican
Phil Jennerjahn, Republican
David R. Hernandez
Howard L. Berman, Democratic
David L. Miller, Republican
Stephen C. Smith, Republican
Joe Baca, Democratic
Morgan Osborne, Republican
Benjamin Campos, Republican
Ed Royce, Republican
Bob Flores, Democratic
Janice Hahn, Democratic
Gary Delong, Republican
State Senator; District 21
Steve Knight, Republican
Bill Emmerson, Republican
Gilbert V. Gonzales, Republican
Todd Zink, Republican
Robert "Bob" Huff, Republican
Charlotte A. Svolos, Republican
State Assembly
Member of the State Assembly; District 36
Ron Smith, Republican
Scott Thomas Wilk, Republican
Donna Lowe, Republican
Greg Krikorian, Republican
Jeff Gorell, Republican
Chris Kolski, Republican
Jay L. Stern, Republican
Joe M. Gardner, Republican
Matthew Lin, Republican
Kenny Coble, Republican
Jose Trinidad Aguilar, Republican
Keith Brandon McCowen, Republican
Curt Hagman, Republican
Noel A. Jaimes, Republican
Patricia A. Kotze-Ramos, Republican
Jack M. Guerrero, Republican
Craig Huey, Republican
Martha Flores Gibson, Republican
Council Member; City of Downey; District 1
Roger C. Brossmer
Alex Saab
District Attorney; County of Los Angeles
Governing Board Member; Cerritos Community College District; Trustee Area 1
Robert "Bob" Arthur
Jean M. McHatton
Member, Board of Directors; West Basin Municipal Water District; Division 3
Jake William Townsend
Local Measures
NO — Measure A Appointment of County Assessor — County of Los Angeles
NO — Measure B Safer Sex In the Adult Film Industry Act — County of Los Angeles
NO — Measure C Use of Revenue from Measure 'H' — City of El Monte
NO — Measure D Telecommunications Tax Reduction — City of Downey
NO — Measure E El Camino Community College Improvement/Transfer/Job Training Measure
NO — Measure F El Monte Fairness For Mobilehome Owners Ordinance — City of El Monte
NO — Measure G Cerritos College Job Training and College Transfer Measure
NO — Measure H El Monte Vital City Services/Childhood Obesity Prevention Measure
NO — Measure I Sales Tax Increase to Fund Essential Services — City of La Mirada
NO — Measure J Accelerating Traffic Relief, Job Creation — County of Los Angeles
NO — Measure K School Improvement Bonds — Lynwood Unified School District
NO — Measure L School Improvement Funding — Lancaster Elementary School District
NO — Measure M Business License Tax — City of Artesia
NO — Measure N Hotel Workers' Wages and Sick Leave — City of Long Beach
NO — Measure O Change of Municipal Election Dates — City of Long Beach
NO — Measure P Utility User Tax — City of Bellflower
YES — Measure Q School Improvement Bonds — Redondo Beach Unified School District
NO — Measure R School Improvement Bonds — Rowland Unified School District
NO — Measure S School Improvement Bonds — Temple City Unified School District
NO — Measure T Pomona Citizen's Right to Vote Initiative Measure — City of Pomona
YES — Measure U Pomona City Charter Measure — City of Pomona
NO — Measure V Pomona Transient Occupancy Tax Increase — City of Pomona
NO — Measure W Pomona Real Property Transfer Tax Increase — City of Pomona
NO — Measure X Save Our Pomona Public Library — City of Pomona
NO — Measure Y Temporary Half-Cent Sales Tax — City of Culver City
NO — Measure Z School Improvement Bonds — Whittier City Elementary School District
NO — Measure AA Sales Tax Increase to Fund Essential Services — City of Commerce
YES — Measure ALF Density Limit re Assisted Living Facility — City of Sierra Madre
NO — Measure AA.
NO — Measure BB School Improvement Bonds — Bellflower Unified School District
NO — Measure CC School Improvement Bonds — Covina-Valley Unified School District
NO — Measure CL School Improvement Funding — Local Classrooms Funding Authority
NO — Measure DD School Improvement Bonds — Palmdale Elementary School District
NO — Measure EE School Improvement Bonds — Little Lake City School District
NO — Measure ES Local School Modernization, Academic Improvement and Earthquake and Fire Safety Bond — Santa Monica-Malibu Unified School District
NO — Measure GA Rent Control Adjustments — City of Santa Monica
NO — Measure GG School Improvement Bonds — Inglewood Unified School District
NO — Measure HH Conservation Funding — Mountains Recreation and Conservation Authority
NO — Measure MM Conservation Funding — Mountains Recreation and Conservation Authority
NO — Measure QS Castaic School Improvement Measure
NO — Measure TT Education Funding — Little Lake City Elementary School District
NO — Measure WP Education Funding — Westside Union Elementary School District
NO — Measure WR Reauthorization of School Bonds — Westside Union Elementary School District
Posted in Politics | 1 Comment »
Tags: 2012 Elections, Los Angeles Conservatives Allaince, Los Angeles County, Mobile Voter Guide
Small Class-Size Balloon Punctured Again
It's time to "just say no" to the small class-size pushers and eliminate seniority as a staffing mechanism
Small class size means less work for teachers. Parents seem to think that their child will be better educated in a room with fewer classmates. Unions love fewer kids in a class because it equates to a larger workforce, which means more money and power for them. Only problem is that small class size does not lead to greater student achievement. It just means more hiring, then laying off the same teachers and punishing taxpayers who needlessly pay for a bloatedworkforce.
Last week, the Wall Street Journal published "The Imaginary Teacher Shortage," an op-ed byprofessor of education reform at the University of Arkansas Jay Greene, in which he exposes the small-is-better canard.
For decades we have tried to boost academic outcomes by hiring more teachers, and we have essentially nothing to show for it. In 1970, public schools employed 2.06 million teachers, or one for every 22.3 students, according to the U.S. Department of Education's Digest of Education Statistics. In 2012, we have 3.27 million teachers, one for every 15.2 students.
Greene also addresses the fact that as hiring increases, there is less likelihood of a student getting a good teacher. And having a good teacher is the most important factor in student achievement.
Parents like the idea of smaller class sizes in the same way that people like the idea of having a personal chef. Parents imagine that their kids will have one of the Iron Chefs. But when you have to hire almost 3.3 million chefs, you're liable to end up with something closer to the fry-guy from the local burger joint.
Just three months ago, director of Cato's Center for Educational Freedom Andrew Coulson wrote a similar op-ed in the same newspaper. The subhead in "America Has Too Many Teachers" sets the tone:
Public-school employees have doubled in 40 years while student enrollment has increased by only 8.5%—and academic results have stagnated
In the body of the piece, he gives us some numbers to chew on. Whereas Greene talks specifically about teachers, Coulson refers to the entire "public school workforce."
Since 1970, the public school workforce has roughly doubled—to 6.4 million from 3.3 million—and two-thirds of those new hires are teachers or teachers' aides. Over the same period, enrollment rose by a tepid 8.5%. Employment has thus grown 11 times faster than enrollment. (Emphasis added.) If we returned to the student-to-staff ratio of 1970, American taxpayers would save about $210 billion annually in personnel costs.
I contributed my own two cents on the subject in City Journal in July of 2011.
In 1998, Hoover Institution senior fellow and economist Eric Hanushek released the results of his impressive review of class-size studies. Examining 277 separate studies on the effect of teacher-pupil ratios and class-size averages on student achievement, he found that 15 percent of the studies found an improvement in achievement, while 72 percent found no effect at all—and 13 percent found that reducing class size had a negative effect on achievement. While Hanushek admits that in some cases, children might benefit from a small-class environment, there is no way 'to describe a priori situations where reduced class size will be beneficial.'
So basically, almost three-quarters of all the studies showed no benefit to small class size, and of the rest, almost the same number revealed negative effects as positive ones.
While it is a personal hardship for a teacher to be laid off, no one should be surprised when it happens. When economic times are good, it's easy to buy into more hiring. But good economic times don't last forever and when suddenly we can't afford all the teachers we have hired and some need to be let go, it is brazen of the self-righteous, small class-size true believers to mislead the public with their hand-wringing and political posturing.
And we can't say we weren't warned that there were going to be problems. Back in April of 2004, teacher union watchdog Mike Antonucci wrote,
Enrollment Figures Spell Big Trouble for Education Labor.
The U.S. Department of Education's National Center for Education Statistics (NCES) regularly reviews enrollment figures, comparing past years with expectations for the future. Its most recent report shows clearly that the fat years of teacher employment are over, and the lean years may last much longer than anyone has previously predicted.
NCES compared the period 1988-2001 with its projections for 2001-2013. The differences are stark. While public school enrollment increased 19 percent between 1988 and 2001, it is expected to grow only 4 percent between 2001 and 2013. During the period 1988-2001, the number of public school teachers grew by an astonishing 29 percent. The forecast for 2001-2013 is growth of only 5 percent – or less than 0.4 percent annually.
Then in June 2004, referring to Rankings and Estimates, a National Education Association report, Antonucci wrote,
In 2003-04, American public elementary schools taught 1,649,027 more pupils than they did in 1993-94. But there were 247,620 more elementary school classroom teachers in 2003-04 than there were in 1993-94. Simply put, for every 20 additional students enrolled in America's K-8 schools in the last 10 years, we hired three additional elementary school classroom teachers.
So clearly, having fewer teachers is not necessarily a bad thing, but it is tragic when we lose the good ones. Throughout much of the country, the decisions as to which teachers get laid off are determined by archaic seniority policies. Teachers-of-the-year are laid off before their mediocre or incompetent counterparts simply because the latter may have been hired a few days before the former. This is no way to run an education system. The sooner we get away from the smaller-is-better myth and turn our attention to scrapping the industrial style "last in, first out" method, the better.
Tags: Andrew Coulson, Eric Hanushek, Jay Greene, last in first out, Mike Antonucci, seniority, small class size, teacher shortage
Lindsay Lohan Endorses Republican Candidate Mitt Romney
When it comes to Hollywood endorsements, Republicans usually have to take what they can get. The big names generally tend to swing left-of-center, as Tinseltown's elite regularly host fundraisers and head out on the campaign trail in support of Democratic candidates.
This electoral cycle is no different, however it appears that a few, more prevalent actors and performers are stepping up to the plate to endorse GOP presidential candidate Mitt Romney. Clint Eastwood, Stacey Dash, and now — Lindsay Lohan.
Despite recently getting into an alleged altercation with a Republican congressional staffer, Lohan is anything but turned off by the Grand Old Party's messaging.
While she openly supported President Barack Obama in 2008, Lohan is changing teams. At the center of her decision to select the Republican nominee over the Democratic incumbent? Unemployment.
"I just think employment is really important right now," the troubled star told E!, while at Mr. Pink's Ginseng Drink event in Beverly Hills, California, on Thursday. "So, as of now, Mitt Romney. As of now."
Last month, during Obama's Democratic National Convention speech, Lohan tweeted the president, about the need to cut taxes for "those that are listed on Forbes as 'millionaires.'"
"If they are not, you must consider that as well," Lohan continued in the same social media message.
The message, which was hard to decipher, was subsequently deleted from her feed, although TheBlaze noted that she kept a number of other political tweets up, including one that included a link to contribute to Obama's campaign.
It seems that the starlet's opinions — at least for now — have changed. In 2008, Lohan offered to stump for Obama, but the campaign allegedly turned her down. At the time, it was suspected that the actress was in a same-sex relationship, which purportedly led her to make numerous claims against then vice-presidential candidate Sarah Palin and the Republican Party.
via Lindsay Lohan Endorses Republican Candidate Mitt Romney | TheBlaze.com.
Posted in Politics, Pop Culture | Leave a Comment »
Tags: Clint Eastwood, Lindsay Lohan, Mitt Romney, Stacey Dash
When are you going to Wake Up America?
Dennis Prager speaking at the Wake Up America 2012 Rally at the Federal Building Oct. 7th. in front of 2,500 people.
Looking back thru the past 4 years, many " Whens " pop up. Read them all to better understand where we are going as a country….
WHEN – he refused to disclose who donated money to his election campaign, as other candidates had done, people said it didn't matter.
WHEN – he received endorsements from people like Louis Farrakhan, Muramar Kaddafi and Hugo Chavez, people said it didn't matter.
WHEN – it was pointed out that he was a total newcomer and had absolutely no experience at anything except community organizing, people said it didn't matter.
WHEN – he chose friends and acquaintances such as Bill Ayers and Bernadine Dohrn who were revolutionary radicals, people said it didn't matter.
WHEN – his voting record in the Illinois Senate and in the U.S. Senate came into question, people said it didn't matter.
WHEN – he refused to wear a flag lapel pin and did so only after a public outcry, people said it didn't matter.
WHEN – people started treating him as a Messiah and children in schools were taught to sing his praises, people said it didn't matter.
WHEN – he stood with his hands over his groin area for the playing of the National Anthem and Pledge of Allegiance, people said it didn't matter.
WHEN – he surrounded himself in the White House with advisors who were pro-gun control, pro-abortion, pro-homosexual marriage and wanting to curtail freedom of speech to silence the opposition, people said it didn't matter.
WHEN – he said he favors sex education in kindergarten, including homosexual indoctrination, people said it didn't matter.
WHEN – his personal background was either scrubbed or hidden and nothing could be found about him, people said it didn't matter.
WHEN – the place of his birth was called into question, and he refused to produce a birth certificate, people said it didn't matter.
WHEN – he had an association in Chicago with Tony Rezco – a man of questionable character and who is now in prison and had helped Obama to a sweet deal on the purchase of his home – people said it didn't matter.
WHEN – it became known that George Soros, a multi-billionaire Marxist, spent a ton of money to get him elected, people said it didn't matter.
WHEN – he started appointing White House Czars that were radicals, revolutionaries, and even avowed Marxist /Communists, people said it didn't matter.
WHEN – he stood before the Nation and told us that his intentions were to "fundamentally transform this Nation" into something else, people said it didn't matter.
WHEN – it became known that he had trained ACORN workers in Chicago and served as an attorney for ACORN, people said it didn't matter.
WHEN – he appointed cabinet members and several advisers who were tax cheats and socialists, people said it didn't matter.
WHEN – he appointed a Science Czar, John Holdren, who believes in forced abortions, mass sterilizations and seizing babies from teen mothers, people said it didn't matter.
WHEN – he appointed Cass Sunstein as Regulatory Czar who believes in "Explicit Consent," harvesting human organs without family consent and allowing animals to be represented in court, while banning all hunting, people said it didn't matter.
WHEN – he appointed Kevin Jennings, a homosexual and organizer of a group called Gay, Lesbian, Straight, Education Network as Safe School Czar and it became known that he had a history of bad advice to teenagers, people said it didn't matter.
WHEN – he appointed Mark Lloyd as Diversity Czar who believes in curtailing free speech, taking from one and giving to another to spread the wealth, who supports Hugo Chavez, people said it didn't matter.
WHEN – Valerie Jarrett, an avowed Socialist, was selected as Obama's Senior White House Advisor, people said it didn't matter.
WHEN – Anita Dunn, White House Communications Director, said Mao Tse Tung was her favorite philosopher and the person she turned to most for inspiration, people said it didn't matter.
WHEN – he appointed Carol Browner, a well known socialist as Global Warming Czar working on Cap and Trade as the nation's largest tax, people said it didn't matter.
WHEN – he appointed Van Jones, an ex-con and avowed Communist as Green Energy Czar, who since had to resign when this was made known, people said it didn't matter.
WHEN – Tom Daschle, Obama's pick for Health and Human Services Secretary could not be confirmed because he was a tax cheat, people said it didn't matter.
WHEN – as President of the United States , he bowed to the King of Saudi Arabia , people said it didn't matter.
WHEN – he traveled around the world criticizing America and never once talking of her greatness, people said it didn't matter.
WHEN – his actions concerning the Middle East seemed to support the Palestinians over Israel , our long time ally, people said it didn't matter.
WHEN – he took American tax dollars to resettle thousands of Palestinians from Gaza to the United States , people said it didn't matter.
WHEN – he upset the Europeans by removing plans for a missile defense system against the Russians, people said it didn't matter.
WHEN – he played politics in Afghanistan by not sending troops early-on when the Field Commanders said they were necessary to win, people said it didn't matter.
WHEN – he started spending us into a debt that was so big we could not pay it off, people said it didn't matter.
WHEN – he took a huge spending bill under the guise of stimulus and used it to pay off organizations, unions, and individuals that got him elected, people said it didn't matter.
WHEN – he took over insurance companies, car companies, banks, etc., people said it didn't matter.
WHEN – he took away student loans from the banks and put it through the government, people said it didn't matter.
WHEN – he designed plans to take over the health care system and put it under government control, people said it didn't matter.
WHEN – he claimed he was a Christian during the election and tapes were later made public that showed Obama speaking to a Muslim group and 'stating' that he was raised a Muslim, was educated as a Muslim, and is still a Muslim, people said it didn't matter.
WHEN – he set into motion a plan to take over the control of all energy in the United States through Cap and Trade, people said it didn't matter.
WHEN – he finally completed his transformation of America into a Socialist State , people woke up— but it was too late. Add these up one by one and you get a phenomenal score that points to the fact that Barrack Hussein Obama is determined to turn America into a Marxist-Socialist society. All of the items in the preceding paragraphs have been put into place. All can be documented very easily. Before you disavow this do an Internet search. The last paragraph alone is not yet cast in stone. You and I will write that paragraph.
Will it read as above or will it be a happier ending for most of America ?
Don't just belittle the opposition. Search for the truth. We all need to pull together or watch the demise of a free democratic society. Pray for Americans to seek the truth and take action for it will keep us FREE. Our biggest enemy is not China, Russia , North Korea or Iran . Our biggest enemy is a contingent of politicians in Washington , DC . The government will not help, so we need to do it ourselves.
Posted in Big Government, Crime & Corruption, Politics | 1 Comment »
Tags: communist, corruption, Dennis Prager, fraud, Marxist, Obama, socialist, Wake Up America 2012 Rally


text:
Q: Finding a specific url in HTML i'm new member sorry about my english but it isn't  my first language.
I would make a python program that extract a specific url from a html page (http://www.kernel.org/pub/linux/kernel/v3.0/). I was able to print on my shell all the link about that page, but i don't know how i extract a specific url, for example linux-3.6.7.tar.bz2. How can i do that?
I would ask you another question: I would that the user to choose the kernel to download on your pc, than specify the kernel, for example 3.2 , 3.3, 3.6, etc etc. How can i make that?
Maybe with the regular expression?
Ps: i imported urllib2, HTMLParser, BeautifulSoup and Re.

A: from urllib2 import Request, urlopen
from BeautifulSoup import BeautifulSoup
req = Request('http://www.kernel.org/pub/linux/kernel/v3.0/')
response = urlopen(req)
content = response.readlines()
soup = BeautifulSoup(''.join(content))
for link in soup.findAll('a', href=True):
    if ('3.6.7.tar.gz' in link.string):
        print link

Using that...
>>> from urllib2 import Request, urlopen
>>> from BeautifulSoup import BeautifulSoup
>>> req = Request('http://www.kernel.org/pub/linux/kernel/v3.0/')
>>> response = urlopen(req)
>>> content = response.readlines()
>>> soup = BeautifulSoup(''.join(content))
>>> for link in soup.findAll('a', href=True):
...     if ('3.6.7.tar.gz' in link.string):
...         print link
...
linux-3.6.7.tar.gz
>>>

If you want to customize the search for user input, use python's raw_input() function...

redpajama_set_name: RedPajamaStackExchange


text:
Rapides agency looks to future with expanded center, new director
More than once, Wade Bond describes the newly expanded Rapides Children's Advocacy Center as "child friendly" as he conducts a tour of the Albert Street building last month.
It's no coincidence, either. Making children as comfortable as possible is essential when they're visiting the center to retell their tales of abuse or trauma.
It's a mission that the center didn't achieve alone, he said. Bond, the executive director of the Rapides Children's Advocacy Center Inc., credited the Red River Delta Law Enforcement Planning Council Inc., which consistently has helped the agency through the years with its services.
The Huie-Dellmon Trust and Coughlin-Saunders Foundation, both in Alexandria, were instrumental in funding the expansion, which started in June and wrapped up in October. "They really made this possible," said Natalie North, the center's communications director.
V&V Builders in Alexandria was the contractor, and Bond called the company one of their "best advocates." The company worked with subcontractors who donated some supplies and services so that the project came in under budget, he said.
"This whole process, someone has been watching over us," said Bond.
And as the expansion ended, the center also got a new director. Brandon Parker, who has worked in law enforcement since 1997, started on Nov. 2.
He worked with the center while he was at the Pineville Police Department, and said the opportunity to help children is "an awesome opportunity."
He recalled a case of his that illustrated the point. One interview was done at the center, while another wasn't — a night-and-day difference, he said.
"It really is invaluable, from a law enforcement perspective."
What the center does is provide a place for children at the center of physical or sexual abuse cases to tell their stories to forensic interviewers while being discreetly recorded. Detectives or Louisiana Department of Child and Family Services workers watch from another room and can communicate with the interviewer.
Children involved in criminal cases sometimes can be interviewed at the center, too. When over, the interview becomes evidence in cases and can be admissible during trials, said Bond.
With the expansion, the center went from one interview room to two. The center has stayed at the Albert Street location even as other programs under the agency's umbrella, like CASA (Court Appointed Special Advocates) have grown and moved elsewhere.
The renovation stayed true to the original feel of the building, which was a home at one time. When children come in for an interview, they're ushered into a room immediately to the right. It has toys and books to keep kids occupied during the wait, along with a huge mural that covers one wall. A large window lets in natural light.
Children get popcorn and drinks before their interview, a tactic used to relax them and to prevent hunger from being a distraction during the process. Bond said that when it's time for the interview, a staff member will escort the child back.
"We're up front as to who we are and what we doing, and they know exactly what's happening through the entire process," he said.
The smaller interview room is a contrast to the waiting room, no decorations or toys. A large pad of paper hangs on one wall, while a seating area is along another wall.
The smaller space helps focus attention, said Bond. And then, children are allowed to tell whatever tales they have.
"This place provides the opportunity for a child to retell if something happened, but it also provides a place for a child to say nothing happened," he said. "As many times as we talked with children who have been abused, and they use this place to share what has happened, we've also had times where children use this place to clarify mistakes or accidents."
The children know that they are being recorded. Some are amused and enjoy that, while others take time to get comfortable. The forensic interviewers are trained to handle the situations, said Bond.
The center is used by law enforcement agencies from throughout Central Louisiana — from Natchitoches Parish in the north to Evangeline Parish in the south and from the Mississippi to Texas borders.
The center also has a mobile unit, a 35-foot bus that staffers used during the renovation. The mobile unit was added after the economic downturn that started around 2008, when the center's staff began to notice a drop in people coming to Alexandria. The reason was economic, said Bond. People couldn't take time away from work, and the price of gasoline also was a factor.
The expansion was part of a three-year strategic plan that the center's board of directors finalized last August. More services are planned to be offered in the future, and those could be announced at an open house the center plans for around the beginning of 2016.
"Our goal is to continue the original mission of the agency, creating a one-stop shop where children's needs are being met through multiple agencies coming together to address and support their time of need," said Bond.
And he said Central Louisiana continues to stand behind the agency.
"There's a lot of growth and prosperity within our communities, and the fact that people are willing to address child abuse and help these victims of a crime that is 100 percent preventable, it's a good community to be a part of."


text:
Reversal of hippocampal neuronal maturation by serotonergic antidepressants
Katsunori Kobayashi, Yumiko Ikeda, Atsushi Sakai, Nobuyuki Yamasaki, Eisuke Haneda, Tsuyoshi Miyakawa, Hidenori Suzuki
Division of Systems Medical Science
Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety disorders, and increasing evidence suggests potential use of these drugs beyond current antidepressant therapeutics. Facilitation of adult neurogenesis in the hippocampal dentate gyrus has been suggested to be a candidate mechanism of action of antidepressant drugs, but this mechanism may be only one of the broad effects of antidepressants. Hereweshow a distinct unique action of the serotonergic antidepressant fluoxetine in transforming the phenotype of mature dentate granule cells. Chronic treatments of adult mice with fluoxetine strongly reduced expression of the mature granule cell marker calbindin. The fluoxetine treatment induced active somatic membrane properties resembling immature granule cells and markedly reduced synaptic facilitation that characterizes the mature dentate-to-CA3 signal transmission. These changes cannot be explained simply by an increase in newly generated immature neurons, but best characterized as "dematuration" of mature granule cells. This granule cell dematuration developed along with increases in the efficacy of serotonin in 5-HT4 receptor-dependent neuromodulation and was attenuated in mice lacking the 5-HT4 receptor. Our results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-HT4 receptor-mediated signaling may play a critical role in this distinct action of antidepressants. Such reversal of neuronal maturation could affect proper functioning of the mature hippocampal circuit, but may also cause some beneficial effects by reinstating neuronal functions that are lost during development.
https://doi.org/10.1073/pnas.0912690107
Parahippocampal Gyrus
Kobayashi, K., Ikeda, Y., Sakai, A., Yamasaki, N., Haneda, E., Miyakawa, T., & Suzuki, H. (2010). Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proceedings of the National Academy of Sciences of the United States of America, 107(18), 8434-8439. https://doi.org/10.1073/pnas.0912690107
Kobayashi, Katsunori ; Ikeda, Yumiko ; Sakai, Atsushi ; Yamasaki, Nobuyuki ; Haneda, Eisuke ; Miyakawa, Tsuyoshi ; Suzuki, Hidenori. / Reversal of hippocampal neuronal maturation by serotonergic antidepressants. In: Proceedings of the National Academy of Sciences of the United States of America. 2010 ; Vol. 107, No. 18. pp. 8434-8439.
@article{1102fb27534644c4a7e8c1a0152fd183,
title = "Reversal of hippocampal neuronal maturation by serotonergic antidepressants",
abstract = "Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety disorders, and increasing evidence suggests potential use of these drugs beyond current antidepressant therapeutics. Facilitation of adult neurogenesis in the hippocampal dentate gyrus has been suggested to be a candidate mechanism of action of antidepressant drugs, but this mechanism may be only one of the broad effects of antidepressants. Hereweshow a distinct unique action of the serotonergic antidepressant fluoxetine in transforming the phenotype of mature dentate granule cells. Chronic treatments of adult mice with fluoxetine strongly reduced expression of the mature granule cell marker calbindin. The fluoxetine treatment induced active somatic membrane properties resembling immature granule cells and markedly reduced synaptic facilitation that characterizes the mature dentate-to-CA3 signal transmission. These changes cannot be explained simply by an increase in newly generated immature neurons, but best characterized as {"}dematuration{"} of mature granule cells. This granule cell dematuration developed along with increases in the efficacy of serotonin in 5-HT4 receptor-dependent neuromodulation and was attenuated in mice lacking the 5-HT4 receptor. Our results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-HT4 receptor-mediated signaling may play a critical role in this distinct action of antidepressants. Such reversal of neuronal maturation could affect proper functioning of the mature hippocampal circuit, but may also cause some beneficial effects by reinstating neuronal functions that are lost during development.",
author = "Katsunori Kobayashi and Yumiko Ikeda and Atsushi Sakai and Nobuyuki Yamasaki and Eisuke Haneda and Tsuyoshi Miyakawa and Hidenori Suzuki",
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Kobayashi, K, Ikeda, Y, Sakai, A, Yamasaki, N, Haneda, E, Miyakawa, T & Suzuki, H 2010, 'Reversal of hippocampal neuronal maturation by serotonergic antidepressants', Proceedings of the National Academy of Sciences of the United States of America, vol. 107, no. 18, pp. 8434-8439. https://doi.org/10.1073/pnas.0912690107
Reversal of hippocampal neuronal maturation by serotonergic antidepressants. / Kobayashi, Katsunori; Ikeda, Yumiko; Sakai, Atsushi; Yamasaki, Nobuyuki; Haneda, Eisuke; Miyakawa, Tsuyoshi; Suzuki, Hidenori.
In: Proceedings of the National Academy of Sciences of the United States of America, Vol. 107, No. 18, 04.05.2010, p. 8434-8439.
T1 - Reversal of hippocampal neuronal maturation by serotonergic antidepressants
AU - Kobayashi, Katsunori
AU - Ikeda, Yumiko
AU - Sakai, Atsushi
AU - Yamasaki, Nobuyuki
AU - Haneda, Eisuke
AU - Miyakawa, Tsuyoshi
AU - Suzuki, Hidenori
N2 - Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety disorders, and increasing evidence suggests potential use of these drugs beyond current antidepressant therapeutics. Facilitation of adult neurogenesis in the hippocampal dentate gyrus has been suggested to be a candidate mechanism of action of antidepressant drugs, but this mechanism may be only one of the broad effects of antidepressants. Hereweshow a distinct unique action of the serotonergic antidepressant fluoxetine in transforming the phenotype of mature dentate granule cells. Chronic treatments of adult mice with fluoxetine strongly reduced expression of the mature granule cell marker calbindin. The fluoxetine treatment induced active somatic membrane properties resembling immature granule cells and markedly reduced synaptic facilitation that characterizes the mature dentate-to-CA3 signal transmission. These changes cannot be explained simply by an increase in newly generated immature neurons, but best characterized as "dematuration" of mature granule cells. This granule cell dematuration developed along with increases in the efficacy of serotonin in 5-HT4 receptor-dependent neuromodulation and was attenuated in mice lacking the 5-HT4 receptor. Our results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-HT4 receptor-mediated signaling may play a critical role in this distinct action of antidepressants. Such reversal of neuronal maturation could affect proper functioning of the mature hippocampal circuit, but may also cause some beneficial effects by reinstating neuronal functions that are lost during development.
AB - Serotonergic antidepressant drugs have been commonly used to treat mood and anxiety disorders, and increasing evidence suggests potential use of these drugs beyond current antidepressant therapeutics. Facilitation of adult neurogenesis in the hippocampal dentate gyrus has been suggested to be a candidate mechanism of action of antidepressant drugs, but this mechanism may be only one of the broad effects of antidepressants. Hereweshow a distinct unique action of the serotonergic antidepressant fluoxetine in transforming the phenotype of mature dentate granule cells. Chronic treatments of adult mice with fluoxetine strongly reduced expression of the mature granule cell marker calbindin. The fluoxetine treatment induced active somatic membrane properties resembling immature granule cells and markedly reduced synaptic facilitation that characterizes the mature dentate-to-CA3 signal transmission. These changes cannot be explained simply by an increase in newly generated immature neurons, but best characterized as "dematuration" of mature granule cells. This granule cell dematuration developed along with increases in the efficacy of serotonin in 5-HT4 receptor-dependent neuromodulation and was attenuated in mice lacking the 5-HT4 receptor. Our results suggest that serotonergic antidepressants can reverse the established state of neuronal maturation in the adult hippocampus, and up-regulation of 5-HT4 receptor-mediated signaling may play a critical role in this distinct action of antidepressants. Such reversal of neuronal maturation could affect proper functioning of the mature hippocampal circuit, but may also cause some beneficial effects by reinstating neuronal functions that are lost during development.
U2 - 10.1073/pnas.0912690107
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Kobayashi K, Ikeda Y, Sakai A, Yamasaki N, Haneda E, Miyakawa T et al. Reversal of hippocampal neuronal maturation by serotonergic antidepressants. Proceedings of the National Academy of Sciences of the United States of America. 2010 May 4;107(18):8434-8439. https://doi.org/10.1073/pnas.0912690107
10.1073/pnas.0912690107


There is no doubt trees can cause damage and be damaged in storms. However, appropriately placed and maintained trees can help reduce damage to structures in storms by deflecting wind, and reduce damage to trees. Appropriate actions includes proper placement and planting, and structural pruning prior to the storm. Species selection can also be somewhat helpful in avoiding some damage.
Click the link below for tips on how to protect your home from storm damage.
This commercial unit flooded along with 3 of its neighbors.
SERVPRO was quick to respond and handled the situation like professionals.
We removed all water and all businesses including a hair salon was able to resume business the very next day!
This cabinet was pulled from a kitchen in Danville, CA. There was a pipe leak in the ceiling that was going for a few days and caused a significant amount of damage to the kitchen ceiling. This cabinet was the lone cabinet that needed to be removed due to the mold on the back side.
This office in Emeryville, CA fell victim to a water intrusion that came from the double doors. There was enough water to break the weather strip and infiltrate the office.
In this photo you can see the result smoke can have on a kitchen even when the fire doesn't physically reach it. Fortunately, this kitchen can be cleaned of any smoke damage.
This apartment was flooded due to a toilet overflow from a shared line in an apartment. As you can see in this photo there is substantial amount of water that is leftover after the carpets were removed.
In this photo you can see the results from a fire damage that happened in this home. Sometime you are lucky and can save belongings, but sometimes the fire is so extensive there is not much to be salvaged.
This kitchen and hallway had a significant amount of mould growth, so much that over four feet high of drywall needed to be removed so that we could clean and treat the wood framing!
This water damage was due to a clogged toilet had overflown in the downstairs bathroom across the hall. There was a significant amount of standing water on this carpet and pad which needed to be removed and dried.
This white cabinet looked fine from the outside but once we removed it from the wall we revealed mold growth on it and the wall behind it. In the photo you can see the black mold along the bottom of the cabinet and the wall.
This stairwell may look clean now but prior to the demolition and remediation, it was covered inside and out with black mold. This photo shows the post mold cleanup we performed. Another job well done by our expert technicians.
This picture is an after shot of the mold remediation we performed on a boiler/storage room for a large commercial building in Emeryville, CA. The owners had no clue how long it had been going on so we quickly removed and cleaned it for reconstruction.
This elementary school suffered water damage due to storms in Northern California. The storage room where they kept equipment for computers and P.E. had standing water that needed to be extracted and dried. The cause of the damage was a leaky roof that was fixed while SERVPRO of Pleasanton/Dublin was on site.
This tube is one of many that are drying the tile floor from the floor below. When we can, we try to dry out tile by getting creative. This is just an example of one of the ways to achieve this goal.
This heavily saturated carpet was worth saving so we removed the wet pad to reveal the concrete slab. Our air movers and dehumidifiers were placed under the carpet to dry out both in one shot.
These air movers are drying out the walls that got wet due to a clogged sink that ran overnight. The small amount of carpet that was removed revealed wet sub floor that began to dry.
This pool house had water that was standing on the tiles. This photo was before we had gotten in to begin the dry out process. After setting our equipment we removed the baseboard and drilled holes to dry out the wall cavities. Limited damage and a quick turnaround is always the goal.
This attic fell victim to heavy storms in Northern California. After the insulation was removed we were able to set up dehumidifiers and air movers to begin the dry-out process. Luckily, no lumber needed to be replaced and the attic dried out quickly.
This dehumidifier is taking the moisture out of the room because the fire sprinklers were going off and completely saturated the room. Our technicians wanted to prevent mold growth on top of the fire damage.
Sometimes the damage from fire is so severe we simply can't save anything. Unfortunately, this does happen but our technicians at SERVPRO of Pleasanton/Dublin are here to help.
This is a small sample of what smoke damage can do. While the drywall can be cleaned, the curtain and rod were not salvageable, along with all of these electronics. Our goal is to try to save as much as we can so you don't lose anything.
This closet had some mold growing between the sheer wall and drywall. The maintenance noticed water staining and found mold behind the wall which prompted a call to SERVPRO of Pleasanton/Dublin!
In this wall cavity there is a good amount of mold growing due to a water leak. Catching it at the early stage is always best but hard to do when it is hiding behind walls!
It isn't always in the easiest spot to get to, sometimes you have to get down and dirty and crawl to the location. Our technicians are willing to go to the smallest spaces to clean mold, especially under a house.
While this is not an everyday occurrence for many, we at SERVPRO of Pleasanton/Dublin have no problem cleaning up after some messy pigeons. This rooftop fell victim to bird feces but we were able to use our SERVPRO products to make it good as new.
SERVPRO of Pleasanton/Dublin is always ready to extract standing water and restore your facility or home back to normal. While its not every day you experience a loss you can rest assured SERVPRO will be there with our trained professionals and excellent equipment at the ready.
Water damage can happen anywhere. This Job had a calming effect on our crew as they were extracting water and completing the dry out process. It's always stressful for homeowners and business owners when a loss occurs, our job it to make it "Like it never even happened."
This bedroom and the adjacent room suffered substantial water damage to the drywall and the framing. By Speedily extracting the water, and drying out the flooring (the carpets were discarded) and the studs and base plates, water damage was mitigated in this storm damaged Dublin property. SERVPRO techs make "Like it never even happened."
Fire Damage at this Dublin condo left behind some very nasty smoke damage. Our crew at SERVPRO of Pleasanton/Dublin has established procedures utilizing specialized cleaning materials to clean up smoke damage. As you can see in the photo above, items that one may consider being un-restorable can be fully restored to pre-loss condition. If you are confronted with the need for a fire restoration company, call SERVPRO of Pleasanton/Dublin. We have the tools, and we have the expertise, and together, that makes SERVPRO magic. We are available 24 hours a day, seven days a week, 365 days a year to better serve you. Call us any time of the day at (925) 426-2302. We are here for you!
The flat roof allowed the penetration of rainwater through the beams and sheathing onto the drywall ceiling. This Pleasanton water damage was completed by replacing the damaged material. Prior to the installation, the wood was treated for odor and anitmicrobial products.
The standing Black Water, which is sewage contaminated, pathogen laden water, backed up from a closeby restroom. Wearing safety clothing, gloves, and goggles, the technicians removed the offensive water. The quick extraction saved the varnished hardwood court flooring from water damage in this Pleasanton gym.
The steady seepage of water finally caused mold damage to this Dublin bathroom. The formica paneling, and the framing was replaced after an anti-fungal agent was sprayed in the affected area. Mold infestations need to be taken very seriously.


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Python Mini-Course University of Oklahoma Department of Psychology Lesson 28 Classes and Methods 6/17/09 Python Mini-Course: Lesson 28 1.
Download ppt "Python Mini-Course University of Oklahoma Department of Psychology Lesson 28 Classes and Methods 6/17/09 Python Mini-Course: Lesson 28 1."
Exception Handling Genome 559. Review - classes 1) Class constructors - class myClass: def __init__(self, arg1, arg2): self.var1 = arg1 self.var2 = arg2.
Python Programming Chapter 13: Classes and Functions Saad Bani Mohammad Department of Computer Science Al al-Bayt University 1 st 2011/2012.
Python Mini-Course University of Oklahoma Department of Psychology Day 1 – Lesson 4 Beginning Functions 4/5/09 Python Mini-Course: Day 1 - Lesson 4 1.
Lecture 04 – Classes.  Python has a number of classes built-in  lists, dictionaries, sets, int, float, boolean, strings  We can define our own classes.
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In order to develop an effective resume for a school manager setting, it is important for you to discover your appropriate success and success tales. Yet you have to bear in mind that it is crucial for you to prevent telling half truths as well as exaggerations because a lot of working with managers and recruiters can quickly inform when resumes have been pumped up with decorations. Their employing proficiency makes them efficient in establishing the surplus in your resume.
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Have you launched as well as established new management systems for your company?
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Title: Association of carotid intima media thickness with atherogenic index of plasma, apo B/apo A-I ratio and paraoxonase activity in patients with non-alcoholic fatty liver disease.
Meta-analysis showed that pretreatment low ApoA-I level was related to worse survival in patients with various tumors. Serum ApoA-I level might be a powerful and noninvasive biomarker to predict cancer prognosis.
Title: Prognostic Significance of Pretreatment Apolipoprotein A-I as a Noninvasive Biomarker in Cancer Survivors: A Meta-Analysis.
Significant prognostic risk factors for the mentioned comorbid pathologies were lipid metabolism parameters HDL-Ch, LDL-Ch, VLDL-Ch and carrier state of the +83T allele of the ApoA1 gene and Del allele of the ApoB gene.
Title: Predictive Models for the Risk of Dyslipidemia in Adolescents with Essential Arterial Hypertension.
Title: Apolipoprotein A-I directly interacts with extracellular domain 1 of human ABCA1.
HDAC3 inhibitor treatment can suppress HCV replication, an effect that was likely mediated via downregulation of Apo-A1 and upregulation of LEAP-1.
Title: Histone Deacetylase 3 Inhibitor Suppresses Hepatitis C Virus Replication by Regulating Apo-A1 and LEAP-1 Expression.
These results argue for a protective effect of EGCG on apoA-I amyloid associated with atherosclerosis and suggest that EGCG-induced remodeling of amyloid may be tightly regulated by GAGs and other amyloid co-factors in vivo, depending on EGCG bioavailability.
Title: Epigallocatechin-3-gallate remodels apolipoprotein A-I amyloid fibrils into soluble oligomers in the presence of heparin.
In conclusion, low serum APOA1 levels are associated with advanced stage and systemic inflammation, while serum APOB does not significantly correlate with tumor stage.
Title: Decreased serum apolipoprotein A1 levels are associated with poor survival and systemic inflammatory response in colorectal cancer.
ApoA-I, apoB and the apoB/apoA-I ratio showed strong association with ultrasound indicators of carotid atherosclerosis in ischemic stroke patients.
Title: Association between Apolipoproteins AI and B and Ultrasound Indicators of Carotid Atherosclerosis.
Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic.
Title: Structural stability and local dynamics in disease-causing mutants of human apolipoprotein a-I: what makes the protein amyloidogenic?
Case Report: patient with amyloidosis caused by a liver-derived protein apolipoprotein A1 underwent combined liver-kidney transplantation and ESI mass spectrometry demonstrated decrease APOA1 expression.
Title: Novel TOF-MS Means of Quantifying ApoAI Amyloid Protein Load After Combined Liver Kidney Transplantation.
A genome wide association study identifies common variants associated with lipid levels in the Chinese population.
A null mutation in human APOC3 confers a favorable plasma lipid profile and apparent cardioprotection.
Common variants at 30 loci contribute to polygenic dyslipidemia.
Genetic variants influencing circulating lipid levels and risk of coronary artery disease.
Genome-wide association study identifies genes for biomarkers of cardiovascular disease: serum urate and dyslipidemia.
Genome-wide scan identifies variation in MLXIPL associated with plasma triglycerides.
Large-scale genome-wide association studies in East Asians identify new genetic loci influencing metabolic traits.
Loci influencing lipid levels and coronary heart disease risk in 16 European population cohorts.
Newly identified loci that influence lipid concentrations and risk of coronary artery disease.
Plasma lipids, genetic variants near APOA1, and the risk of infantile hypertrophic pyloric stenosis.
Salt-inducible kinase 3, SIK3, is a new gene associated with hearing.
Six new loci associated with blood low-density lipoprotein cholesterol, high-density lipoprotein cholesterol or triglycerides in humans.
PPAR Alpha Pathway, organism-specific biosystemPPAR alpha (also known as NR1C1) is a nuclear receptor that is involved with transcriptional regulation of genes involved in beta-oxidation, metabolism, fatty acid transport, etc.
Scavenging by Class B Receptors, organism-specific biosystemClass B receptors have two transmembrane domains separated by an extracellular loop (reviewed in Adachi and Tsujimoto 2006, Areschoug and Gordon 2009).
Homologs of the APOA1 gene: The APOA1 gene is conserved in chimpanzee, Rhesus monkey, dog, cow, mouse, rat, chicken, zebrafish, and frog.
Transcript Variant: This variant (1) represents the longest transcript and encodes the longest isoform. Variants 1-3 encode the same isoform (1).
Transcript Variant: This variant (2) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
Transcript Variant: This variant (3) differs in the 5' UTR compared to variant 1. Variants 1-3 encode the same isoform (1).
Transcript Variant: This variant (4) differs in the 5' UTR, lacks a portion of the 5' coding region and uses a downstream translation start site compared to variant 1. The encoded isoform (2) has a shorter N-terminus and lacks a predicted signal peptide compared to isoform 1.


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Home News Callum McGregor fired up for Champions League bid after 'nice taste' against PSG
Callum McGregor fired up for Champions League bid after 'nice taste' against PSG
The Hoops were beaten 4-0 in Paris but McGregor feels the friendly will have benefited his team-mates.
Callum McGregor believes Tuesday's gruelling workout against Paris St Germain was the perfect warm-up for Celtic's Champions League bid.
Neil Lennon's side were outclassed by Neymar and company at the Parc des Princes, with the French giants romping to a 4-0 win.
But stand-in skipper McGregor, who took the armband in the absence of injured captain Scott Brown, feels the friendly clash with the big-spending Parisians is just what the Hoops need as they get set for another assault on the group stages.
Celtic's opening qualifier on August 19 is less than a month away and the Scottish champions will have to overcome four opponents before they can take their place among Europe's elite.
But McGregor is sure his side will be more than ready for that quest having been pushed to the limit by PSG.
The Scotland midfielder told CelticTV: "We spoke about it in the changing room after the game. The Champions League is the level that we want to play at, so the PSG game is a nice taste of what could be.
"But we always know how hard it is to get there and that's the level that we have to reach. It was a very good exercise, 90 minutes in the legs, and good to see the opposition.
"I felt good out there. It's 90 minutes and a tough, tough shift as well. You could play a full game against lesser opposition and it's not as hard on the legs, but that's a real big shift where you're always looking, running and concentrating.
"It's mental and physical fitness. I think the boys are looking in good shape and we'll try and take the positives from the game."
Celtic showed some fleeting moments of quality against their hosts from the French quality but ultimately sank to a heavy defeat.
World Cup-winner Kylian Mbappe put PSG ahead inside a minute before goals from Neymar, Anders Herrara and Pablo Sarabia rubbed salt into Celtic's wounds.
"It was tough," added McGregor. "When you come up against top-class opposition, you know it's going to be a test. It was a match that the boys were looking forward to, and you can obviously see the difference in quality.
"We conceded a goal a minute in, so we weren't switched on from the start, but I think after that, we got to grips with the game a little bit more.
"We played the shape pretty well, and managed to stifle them on occasion. Against top-class opposition, then we were reasonably happy with that first half.
"We had some good opportunities on the counter-attack. You have to try and be a threat as well when you're playing against a good opposition, and I thought we did that on numerous occasions, in the first half and the second.
"Our play probably did deserve a goal. Pre-season is all about fitness and, again, playing teams like this is a good test for us."
Meanwhile, Celtic's Ladbrokes Premiership clash with St Mirren at Parkhead on Saturday, October 31, has been postponed because of the Hoops' involvement in last season's rearranged William Hill Scottish Cup semi-finals.
Aberdeen's trip to Hamilton and Hibernian's clash with St Johnstone at Easter Road have also been affected, with new dates yet to be confirmed.


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Manchester United Gets Massive Injury Boost Ahead Of Man City Clash
It's not unfair to suggest that Marouane Fellaini is still something of a divisive presence for Manchester United fans. Many suggest that he is symptomatic of a problem that has long-since pervaded Old Trafford of keeping players that aren't up to the high standards that the club once set, whilst others argue that his utilisation causes frequent issues that aren't necessarily his fault.
We saw two sides to the Belgian in this last week or so; the one that was a useful, physical and controlling presence in midfield against Liverpool, and the slack, loose player that we saw against Chelsea in Sunday afternoon's 4-0 drubbing at Stamford Bridge. Fans are so used to seeing the latter that they often discount the former as a mere blip.
Fellaini didn't even make it through Sunday's game, which might be something of a blessing for the man himself. David Luiz lunged in wildly on the first half when the Belgian had the ball and firmly landed his studs onto his opponent's knee. Quite how referee Martin Atkinson could only book the Brazilian for such a reckless challenge and brandish only a warning was beyond the club's fans that afternoon, but it didn't overshadow a wretched performance, whilst also leading to Fellaini's substitution at half time.
Buried in The Times' revelation that some of United's players are 'stunned' by Jose Mourinho's hands-off approach, and frequently lets assistant Rui Faria lead training sessions whilst he either watches from a distance or works in his office is the suggestion that Fellaini only suffered 'minor bruising' in the clash. This means that the former Everton midfielder could be available for Wednesday's EFL Cup third round clash with Manchester City at Old Trafford, or, failing that, Saturday's Premier League meeting with Burnley.
Mourinho may choose to withhold the Belgian for the time being, considering his struggles at the weekend and the fact that he had to be withdrawn during the game. United have several midfield options that they can call upon in his stead; neither Michael Carrick or Morgan Schneiderlin have started a Premier League game this season, and both would be willing and ready to line-up alongside Ander Herrera should the need arise. As such, it might be wise to delay Fellaini's return for the time being, and turn to one of United's more under-utilised options in the centre of the pitch. Given how Fellaini fared at the weekend, it seems a wise move.
1st January Deal? Manchester United Ready To Complete £100,000-A-Week Deal
1st January Deal? £200,000-A-Week Star Set For Manchester United Transfer Deal