Sicamous's Shea Weber, about to destroy another puck, or another goaltender's equipment in this year's Stanley Cup competition.
If Claude is going to wax poetic about all the flying Frenchman out of Quebec, I'm going to have my say about our BC hockey program producing some top tier NHL talent these days. We may not have the flash or flair that the Quebec leagues are known for, but out West we put our workboots on and do one thing right. We win.
While I must admit, this year's NHL Stanley Cup Finals had a distinct je ne sais quois about it, perhaps it was the French-Canadian coaches jawing at each other, the Burrows vs. Bergeron vs. Lapierre "Fingergate", or the fact that Luongo grew up just four blocks away from Marty Brodeur and probably played street hockey with the guy as a kid, if you look deep enough, you'll notice that there is a small contingent of BC born players on both the Boston Bruins' and Vancouver Canucks' rosters; however, though the population may be small, the contributions be mighty.
The better known BC boys are known as serious professionals, on-ice or locker room leaders, and generally reliable hockey players. A quick top ten of British Columbians might go something like: Steve Yzerman, Joe Sakic, Glenn Anderson, Cam Neely, Mark Recchi, Ray Ferraro, the Courtnall brothers, Greg Adams, and Cliff Ronning. But this sampling doesn't tell the story. For every Sakic, there is a Darren McCarthy leading, scoring timely goals, checking other forwards and defending up his teammates. For every Courtnall, Adams and Ronning there is a Doug Lidster, stoically protecting his zone, sweeping mistakes and allowing his forwards to take chances up front. With the BC hockey player you get what you ask for, no frills and no enigmas.
It seems in BC, then, we take our roles seriously and our responsibilities even more so. We are the Western oblivion, the forgotten land tucked away past some mountains, and in the middle of the wild, but there is nothing wild about making sure your roster has at least one of these guys on it. The Vancouver Canucks may not have a Stanley Cup to their credit, but without players born on BC soil, other teams wouldn't either.
At the moment, the NHL is heavy with rugged BC boys who play key roles on the blue line, or physical checking forwards in the mold of Rob Niedermayer, who support their teammates with bodychecks, timely scoring, and occasional fisticuffs. All of the members on this list ooze leadership, and there isn't a team in the NHL that would pass up an opportunity to have him on its roster.
Benn can play all three forward positions, is a lanky 6'2″, and can log heavy minutes. His leadership is a key reason why the Stars are big on Benn, as well as his ability to play in any type of game, whether it be a track meet, or a wrestling match. He's still catching up to his body in some ways, and needs to improve his positional play as well as his on-ice vision, but if the Stars are going to replace the skills of the declining Brendan Morrow, Benn will be a big figure in their future.
When the Maple Leafs made the trade to add the speed demon (when not concussed) Matthew Lombardi and young prospect Cody Franson, the smile that spread silently over Brian Burke's face was palpable. After making moves to acquire Phaneuf last year, who did show signs of returning to his former self, Connolly, and now Lombardi and Franson, all while dumping over 20 players and salaries over the last 2 years alone, the other shoe, has finally dropped. Burke finally got the big defenceman he covets so much, and the Leafs are looking like the most improved team this summer. The 6'5″ Franson will give the blue line the offense it will miss as a result of losing Kaberle, and as he learns to use his massive frame, his still developing offensive acumen, and learn the position from one of the best in Phaneuf (who might also have a thing or two to say about developing potential) he will become the preeminent defenceman in the NHL, and make Sicamous as proud of him as they are of Shea Weber. For that matter, Franson will make Vancouver proud, since he's another byproduct of the WHL's Giants. If Nashville makes the playoffs, or if Goaltender Pekka Rinne has a better season, I'd be amazed. Just watch.
When fellow BC native, Steve Yzerman, traded for the much-beleaguered St. Louis Blues veteran, he knew he was getting a leader, despite what anyone in Blues country was saying. He's a quiet type, and doesn't do anything overly spectacular, but the Canadian Olympic Gold Medallist, and former Blues' captain, instantly solidified a back end which already included the likes of veterans Mattias Ohlund, and Brett Clark, along with top prospect Victor Hedman. Tossing Jeff Beukeboom's son and a third rounder to the Blues was pittance compared to receiving a top-2 defenceman for the next 4 years who will compose a core of the Lightning that will compete for the Stanley Cup as long as they want to. With all due respect to Detroit GM Ken Holland, Brewer is the finest player to ever come out of Vernon, BC, and one of the best D-men in the league today.
The Canucks are probably thankful that the Jets have finally signed Captain Ladd to a new contract, because he was one of the main reasons the Hawks won the Stanley Cup. If it means they only have to play against him twice a year, that's a lot less than being a pain in the rear for 6 games a year and playoffs. He plays an in-your-face brand of hockey that makes him an extremely difficult player to play against, and can check anyone into the ice whenever he is asked. He is the consummate team guy, and is second to none on the penalty kill, using blinding speed to cause point men no end of grief. He drives hard to the net, and he drives his teammates to perform at their best every night. Welcome back Jets, you couldn't have picked a better man for the job.
The oft-injured Horcoff is a captain the way Oilers fans like them lately — gritty, clutch, and passionate about the city and fans for whom they play. That's Horcoff in a nutshell, who will get some help in the leadership department when another former Oiler leader, Ryan Smith, returns to play out his career in Alberta's capital. For what he lacks in the skill department, Horcoff makes up for with sound defensive positioning and the highest level of work rate on the team. He's a good face-off man, and scores goals when you need them. This is a guy who never forgot what it was that made him successful enough to play at the NHL level, and represents your prototypical BC born player.
Carey Price is the best goalie to come out of BC since Andy Moog.
For a change, there are no grumblings in Montreal about how Price faltered in the playoffs. His numbers were even better than his regular season numbers, and to think, this goalie is only 23 years old. When the Habs traded Jan Halak to St. Louis, there was nearly a riot about how they were ripped off and how Price would never be a decent number one. Those fans were wrong. Although still a little inconsistent, Price has developed into the uber-talent everyone thought he would be, showing signs of handling the biggest pressure cooker in the NHL, Montreal. He handles the puck well, covers massive amounts of net, and is beginning to look scarily comfortable in the cage. Now if only management can do something about their pop-gun offense, the team might go places. Without Vancouver BC's own Price, however, this once proud franchise, stacked with Francophone players, would sink like a stone.
For many Canucks fans, this hip-check on Lucic was both the best hit and the worst moment of the series.
Most Canucks fans hadn't seen Hamhuis play enough in Nashville to be able to tell you what they were getting when GM Mike Gillis signed him in 2010. They apparently hadn't watched the Nashville Predators push the Chicago Blackhawks to the limit the year the Hawks took out the Canucks in 6 games for the second straight year. Dan Hamhuis was everywhere that series, and had he been in Nashville instead of Vancouver this year, the Canucks don't win the President's trophy, they don't have the fewest goals against, and they certainly never get past Chicago, Nashville, and San Jose, or win two games against Boston. The main reason fellow D-man Kevin Bieksa looks so dominant, and goaltenders Roberto Luongo and Corey Schneider look like Fort Knox on most nights, is because this guy is in the lineup. Perhaps he isn't 6'8″ like Chara, and maybe he doesn't have a big-time Howitzer like Ehrhoff, but he is uncannily Lidstrom-esque in his positioning and hockey smarts. He's also one of the nicest guys you can ever meet.
Seabrook giving definition to the term "Flying Frenchman"
To me, the most surprising fact about Brent Seabrook isn't that he was able to take a Raffi Torres blindside hit that made him concussed, and got up to fight him anyway, but rather, that he's from Richmond, BC. Now, don't get me wrong, I have nothing against the Asian population of Vancouver whatsoever, but if you haven't been to Richmond, then you should know it's more likely to produce a future badminton star than it is one of Canada's finest defencemen. Seabrook doesn't bang as many bodies in the regular season as fans would like, but in the playoffs, there is nobody meaner than Seabrook. The never-nervous blueliner always seems to know what to do with the puck, and makes opposing forwards nervous when they are around his goaltender's net. His mobility from the back end is second to none, and having him on the ice is like having another captain. Another Olympic Gold Medallist, who will probably have his number retired in Chicago, and perhaps by the Hall of Fame when all is said and done.
East Vancouver is just, well, a little different. When you see that cocky, grinning s.o.b. Lucic who backs down from no one, and stares down everyone like they're intruders in his home, that's what growing up in East Van is all about. The Canucks continue to make mistakes in passing up opportunities to draft home-grown talents like these, who was passed up by the team, at the time, Dave Nonis, for Michael Grabner, who became the bench riding Keith Ballard, and the poor-man's Lucic, Viktor Oreskovich. It's not as though the Canucks didn't know about this monstrous, hulking winger, after all, he played in our own back yard at the Pacific Coliseum for the Vancouver Giants of the WHL. Even then, fans were screaming on Sportstalk radio shows for the Canucks to Draft this kid with size, strength, grit, determination, and fire in the belly, in essence, what every team needs to win a Stanley Cup. It goes to show you that sometimes, fans, and not the pro-scouts, GM's or coaches, know Stanley Cup champs when they see one. Guess what? He just became one.
Without Weber, it is largely believed that Nashville will sink to the bottom of the standings, and the team will fold, no matter what Barry Trotz pulls out of his magic bag of tricks. He is just that good. The future Norris trophy winner lived a charmed life until the Vancouver Canucks proved they didn't have enough firepower to compete with the league's best. The Preds may not have the bankroll to compete with the league's best either, as the Weber contract still looms over the franchise which sees it fit to give up any number of pieces just to lock their captain up for the rest of his career. I'm not sure it will happen, because nobody wanted to win more than Shea Weber. To see fellow Sicamous teammate, up-and-comer Cody Franson get shipped to the Leafs for practically nothing, couldn't have sat well with the 6'4″, 234 lbs. Defenceman.
How good is Weber? He has won the World Championship of Hockey in 2007, he helped team Canada win Gold at the 2010 Olympic games, he is an all-star, won the hardest shot competition, demolished the Anaheim Ducks in every regard in the first round of the 2011 playoffs, won the team's MVP award, and nearly the Norris trophy (9 votes shy) as the league's best defenceman. He is as complete a defenceman as they come, and he is just getting started. He will win a Stanley Cup, but unless Nashville can make some moves to look a little more respectable in the forward department, Weber will do it with another team. Maybe Nashville can use some French-Canadians on their roster, eh?


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Photo Credit: S & A
Film , News , Short Films
#ShortFilmShoutout: 'Boxed' Takes Viewers On Henry 'Box' Brown's Harrowing Escape To Freedom
Monique Jones
This is installment #23 of Shadow And Act's #ShortFilmShoutout series.
Warning: This short film features an allusion to sexual assault.
Thanks to films like 12 Years a Slave and Harriet, more attention is being paid to slave narratives that haven't been explored in mainstream media. Wanjiru M. Njendu joins this movement with her short film Boxed, a fictionalized account of Henry "Box" Brown's journey to freedom by mailing himself from Virginia to Philadelphia.
The short film has qualified for FYC submission to the 2020 Academy Awards for Best Short Film – Live Action category. It is certainly worthy of recognition as it has already been featured at 50 festivals so far, with the list continuing to grow. Viewers will find that the short film, six minutes long, successfully recreates the tension, fear and despair Brown (Adetokumboh M'Cormack) must have felt during his unconventional and terrifying journey to freedom. Njendu's cinematographer and co-producer Bongani Mlambo helped establish this fear visually with arresting close-ups of Henry's face as terror and guilt at not being able to help other Black people in need (in particular a young woman who is raped by a white man) flash across his face.
Njendu says that she came up with the idea for the film after speaking with The Fresh Prince of Bel-Air star Karyn Parsons, who created Sweet Blackberry, a company that creates animations to teach children about Black history. The first story Sweet Blackberry covered was Brown's amazing journey.
"I latched onto the idea of telling Henry's story, but as a psychological thriller with the audience in the box with him for the duration of the trip," she wrote. "I thought inside the box."
Whereas M'Cormack provides the on-screen presence for Brown, the rest of the cast provide their work in ADR sessions, with sounds designed to be added in post-production. Composer Dara Taylor and the voice cast, including Peres Owino, William Joseph Hill, Gregor Manns, Emerson Gregori and Mikey Kettinger, help to complete the experience of tension and fear.
With Boxed telling the story of Brown, it's possible that a new path is being paved for filmmakers to explore more underrepresented slave narratives. Not only could this provide much-needed variety to a genre that is now in danger of becoming a trope of itself, but it could also give audience members a wider scope of how inhumane and emotionally scarring slavery actually was. Check out the trailer for Boxed below. You can help support Boxed via its GoFundMe page. You can also learn more about the film on its website.
#ShortFilmShoutout: 'Bushbaby' Tackles Gentrification In Bed-Stuy, Brooklyn
#ShortFilmShoutout: Romantic Short 'HOMI3S' Perfectly Captures Awkward Run-Ins Of Millennial Dating
#ShortFilmShoutout: The Semi-Autobiographical 'What This Place Meant' Showcases The Notion And Emotional Toll Of Rebuilding
#ShortFilmShoutout: 'Drive Slow' Explores The Feeling Of Applying To College Through The Lens Of A Chicago Teen
#ShortFilmShoutout: Black Girl Magic Meets Period Piece Mystery In 'Beauty'
#ShortFilmShoutout: The Animated Film 'Felix' Is A Sweet Tearjerker
#ShortFilmShoutout: 'The Dispute' Is 'B.A.P.S.' Meets 'Atlanta,' With A Focus On Friendship And Laid Edges
Black Filmmakers, Submit Your Film To #ShortFilmShoutout
Photo credit: Wanjiru M. Njendu
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Rich writes: "The practical question coming out of the debate is not whether Clinton turned some Trump supporters to her side (surely not), or vice versa (also not). It is simply: Did Clinton arouse more enthusiasm among millennials, white and black and Hispanic, who were never going to vote for Trump but might vote for Gary Johnson or skip Election Day altogether?"
Hillary Clinton and Donald Trump. (photo: Getty Images)
How Hillary Clinton's Pitch-Perfect Put-Downs May Have Changed the Race
By Frank Rich, New York Magazine
Most weeks, New York Magazine writer-at-large Frank Rich speaks with contributor Alex Carp about the biggest stories in politics and culture. Today: the first 2016 presidential debate.
oing into last night's debate, polls showed Hillary Clinton's lead over Donald Trump continuing to shrink. But a CNN/ORC instant poll right after the debate found that she'd won it by more than a two-to-one margin. Should her performance last night be enough to move the needle back?
We'll have to wait for polls a few days from now for the answer to that question. But let's pause for one moment to savor how Clinton performed last night. My heart sank with her first answer, to a question about job creation: her usual diligent wonky A-student's recitation of a list of prefab economic proposals that the brain instantly tunes out, that no one thinks will ever happen, and that have been promised by Democratic politicians in every presidential election since Carter and then Mondale were slaughtered by Ronald Reagan.
But what followed was something of a miracle: Hillary from then on mustered a pitch-perfect response to the boor on the other side of the split screen. She stuck to substance (of which he had none) and waited out his diatribes (many long waits) either by looking slightly bemused or by outright laughing at his absurdities. She refused to get lost in the weeds of his many lies and factual errors — urging viewers to consult fact-checkers online instead — and allowed herself some actual wit. "If we're actually going to look at the facts … " she said early on, throwing the line away lightly but devastatingly (though her target seemed oblivious to the dig). When Trump went on and on to try to pin his own birtherism campaign on her, a foolhardy errand in which he assumed the audience understood his oblique references to Sidney Blumenthal and Patti Solis Doyle, she retorted, smilingly, with "Just listen to what you heard." It was a perfect response, directing the audience simply to watch her opponent as he choked on his own incoherent gusher of words. And when Trump went on his bizarre tear about how he had really, truly been opposed to the Iraq War early on, and how Sean Hannity could vouch for him despite all the evidence to the contrary, she replied with an even bigger smile and the mot juste for the moment: "O-kay!"
Finally, there was that great final-round climax when she refused to allow Trump, who tried to brush past the fact that he had attacked her for not having a "presidential look," to change the subject from "looks to stamina," as she put it. She cited a number of his misogynistic slurs, then brought it home with a fresh incident, his referring to a beauty-pageant contestant who didn't meet his physical standards as "Miss Housekeeping" because she was Hispanic. It was a tough and stirring moment, for which Trump could muster no better response than another attack on Rosie O'Donnell. Sad!
All that said, the margin in the instant debate-night poll was virtually the same as the margin that had Mitt Romney killing Barack Obama in the first debate of 2012. I will say for the hundredth time that the one thing Trump is right about is that his supporters would still vote for him if he shot someone on Fifth Avenue. And they will still vote for him after this debate. This was a big night for fact-checking by a plethora of major news organizations, but what's lost in this frenzy of media empiricism, worthy as it is, is that Trump's supporters don't care about the facts any more than he does. This election is a culture war, not a debate over policy, and in that war Trump is the white-guys' guy.
So the practical question coming out of the debate is not whether Clinton turned some Trump supporters to her side (surely not), or vice versa (also not). It is simply: Did Clinton arouse more enthusiasm among millennials, white and black and Hispanic, who were never going to vote for Trump but might vote for Gary Johnson or skip Election Day altogether? I would hope so, but I certainly don't know.
This was Trump's first one-on-one debate, with less room to hide than he had on the crowded stage of the primaries. Did the spotlight, and a few pointed follow-up questions, show you anything new about how Trump responds to pressure?
It's hard to know how he could have performed worse. He obviously was true to his own pre-debate spin in one respect — it was clear he really did no preparation. His "policies" were content-free. Even the zingers he was supposedly stocking up were nowhere to be found. His main subject, the only one he was passionate about, was himself. Otherwise, he recycled the same old rants ad infinitum. His sole points seemed to be (1) America is a Third World shithole; (2) every other politician is "a disaster"; (3) only he can make everything great again. And his style was, if anything, worse than his content (if not as vacuous). He constantly interrupted Clinton as if he owned the joint and she was an uppity underling. I'd call it mansplaining, except Trump didn't even offer up the mansplanations to go with his obnoxious attitude. He was Ralph Kramden without the wit: I kept half-expecting him to bellow, "Hillary, you're going to the moon!" And his over-the-top facial expressions as she gave her answers were, dare I say it, Al Gore–like in their impatience, petulance, and general asininity. All this from a man who went on at considerable lengths to brag about how he has "a much better temperament than Hillary."
To the vast delight of the internet, Howard Dean tried to explain this performance by tweeting: "Notice Trump sniffing all the time. Coke user?" I doubt it, given Trump's germ phobia and aversion to alcohol. But if he were on cocaine, how would that explain his alternately churlish and meandering presentation? Not what I'd call coked up. Maybe he was OD-ing on his real drug of choice, McDonald's.
The moderator, Lester Holt, couldn't resist some mid-debate fact-checking — like practically everyone else, it seems — but once the candidates got going he largely stepped out of the way. Was this the right strategy?
To his credit, Holt tried to call out Trump on his Iraq War claims, but otherwise he was almost a phantom presence, with no authority or control over the proceedings. His role model could have been Mr. Cellophane in the musical Chicago. He'd tell Trump he had "just ten seconds" to give a rejoinder and then disappear as Trump went on ad infinitum. One way to look at this is that Holt was just the latest NBC anchor (after Joe Scarborough and Matt Lauer) to tilt toward the former star of the network's Apprentice. But in the end, Holt's refusal to police Trump's filibusters, intentionally or not, was a boon to Clinton: As Trump just went on and on unchecked, and she could be seen on the other side of the screen watching with borderline delight as he talked himself into one free-associative cul-de-sac after another, it all accrued to her benefit. It was one smart woman against two less-than-brilliant bros, and, should we still care about such distinctions, she looked like a president while in the end they both seemed to just fade away.


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Arch ! Your favorite !
If the government't of the United States could somehow make the transition from world policeman to lets take care of ourselves, we would be a lot better off.
The President painted himself into a corner when he called for a congressional vote. He is now in the position of not getting approval and yet going ahead with the strikes. A no win situation in either case.
He has pretty much ceded leadership to Putin in the matter. Putin comes across as the voice of reason and the president wanting to bomb Syria come hell or high water. Putin as the voice of reason is probably a laugher. I know that I don't trust him.
Would we? Are you so sure? American isolationism prior to WWII meant a late entry into a war that was far harder to win. What evidence do you have that a return to isolationism now wouldn't turn out just as badly, or worse?
Agreed. I wish more people would see that side of the argument. If the European nations would have banded together as soon as Hitler took Czech, things could have been vastly different. It's a good thing we had FDR at that time who realized we needed to do something rather than sit back and watch. President Roosevelt persuaded Congress to repeal the arms embargoes of the Neutrality Acts and worked to establish loop-holes in them to get supplies to our European allies.
The younger people are, the less they seem to be aware that not doing anything has consequences, too. Eventually, something you managed to stay out of draws you in later and at a far greater cost.
Yes, fighting terrorism does help the terrorists get new recruits. However, do we really believe that if we don't fight them they're going to adopt a "live and let live" attitude toward a West they characterize as The Great Satan?
...a West they characterize as The Great Satan?
...a West, especially an England and an America, whose oil-driven Middle Eastern foreign policies have earned the title The Great Satan?
C'mon, Unseen, give us a bit more of the truth, the whole truth, and nothing but the truth.
But do feel free to add enough metaphor to keep us awake long enough to read it.
I don't know about the UK but the US doesn't need Middle Eastern oil and actually doesn't use as much of it as people seem to think.
How much do people seem to think?
Most people seem to think it's all coming from there. Mexico, Canada and South America account for for than half. The Middle East is about 20% with the majority (at least half) of that coming from Saudi Arabia.
U, I have for months not understood your need to dispute, without evidence, so many points raised on T/A discussions. I was glad I wasn't your only target.
A few days ago I saw these words -- the narcissism of unimportant disputes -- and right away thought of you.
The thought didn't support a conclusion but it still brings me smiles.
I generally have always made sure the other side, particularly if it's unpopular, gets a strong defense. Simple as that. An education in philosophy gave me strong critical thinking tools.
If anything is more dangerous to reaching a false conclusion than starting without data or with false data, it's a bunch of people who agree on something, because at that point rational consideration almost always stops dead in its tracks.
U, you mounted a too-hasty defense.
...a bunch of people who agree on something, because at that point rational consideration almost always stops dead in its tracks.
Your defense is too hasty because your bunch of people is on its face a pejorative. Your pejorative is unwarranted because you nowhere allow that the people might be well-informed and might have reached a valid conclusion.
You will more likely find ill-informed people who don't reason to valid conclusions on evangelical websites.
Your defense is too hasty for another reason too.
An education in philosophy gave me strong critical thinking tools.
Your education in philosophy either omitted a caution or you do not remember that caution: That which can be asserted without evidence may be denied without evidence.
Tell us a reason we can believe.


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Miami dismisses transfer forward
By Terrence PayneJan 12, 2017, 7:59 PM EST
For the second time this season, Miami had parted ways with a transfer to the program.
Before the start of Miami's game against No. 20 Notre Dame, the team issued a statement announcing VCU transfer forward Michael Gilmore was dismissed from the program, "for failure to meet team expectations."
Gilmore, nephew of the Hall of Famer Artis Gilmore, was sitting out the season due to NCAA transfer regulations. He was set to have two years of eligibility remaining, beginning at the start of the 2017-18 season. Once listed as a three-start prospect by Rivals — a four-star recruit by ESPN — averaged 2.6 points in 56 appearances for the Rams.
Earlier this season, San Jose State transfer guard Rashad Muhammad, the younger brother of Minnesota Timberwolves wing Shabazz Muhammad, was let go from the program for the same offense as Gilmore. He did not appear in a game for the Hurricanes.
Miami is 11-3 (1-1 ACC) on the season.


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If you want to delete your Facebook account, you most likely noticed that you could discover this alternative that easy.
The alternative you can find is to deactivate your account, and if you do this, your account will not show up to your Facebook friends and also various other users of this social network. If you alter your mind and wish to use Facebook again, all you should do is log in. Your messages, images, friends - whatever will certainly exist.
Once again, if you remove the account, you won't have the ability to reactivate it as well as the content you added will certainly be removed. That is why Facebook advises the users to download the copy of their details. To do that, click on the account menu (triangle symbol located at the upper-right corner), click Settings and after that click "download a copy of your Facebook data", followed by "Start my archive".
As you can see, when the web page opens up, the message will certainly appear to advise you that you will not be able to reactivate your account. If you are sure that you want to do this, click "Delete my account" to send an ask for deletion. Facebook will not remove your account right away, and also you will have few much more days to change your mind. If you do not desire the account to be erased, terminate the demand. When the account is officially erased, you will not have the ability to reactivate it, as well as the only choice will certainly be to produce a brand-new account.


Photo dates from circa 1975.
Tamara Eulalie Harrod aged 87 of Grand Ledge, passed away peacefully on Sunday, September 6, 2009. She was born December 27, 1921 in Paris, France, daughter of Basile and Angele Eulalie (Leleu) Popoff. She was preceded in death by her husband, Dr. Gordon R. Harrod. Surviving is her caregiver and close friend, Hendrik (Jesse) Gilaard. Tamara was an Assistant Professor at Michigan State University's Justin Morrill College and taught French at East Lansing High School for 13 years.


BANGKOK -- Thai shopping mall developer Siam Piwat opens the country's largest commercial complex on Nov. 9 in Bangkok, a $1.6 billion project dubbed Iconsiam that also boasts high-rise condominiums.
Thai conglomerate Charoen Pokphand Group and group real estate developer Magnolia Quality Development also are involved in the project.
The commercial and entertainment hub will include a department store operated by Japan's Takashimaya serving as the core tenant. The total floor space of about 520,000 sq. meters surpasses even retail giant Central Group's CentralWorld mall in the Thai capital.
Two luxury condo towers -- one rising 70 stories and the other 52 -- stand adjacent to the new mall.
Iconsiam could redraw the city's commercial map. The complex sits on the bank of the Chao Phraya River on the western side of central Bangkok, away from the Siam and Sukhumvit areas that serve as the capital city's main shopping districts.
Iconsiam's shopping mall will house many brands entering the Thai market for the first time. The Takashimaya store will carry 500 brands, 80 of which come from Japan and are making their debut in Thailand.


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Home Editorials Hamelin's Pied Piper
Oct 15, 2016, 11:46 IST | हिंदी में पढ़ें
Hamelin's Pied Piper
Editorial by Rama Awasthi
Germany is a country of folk and fairy tales. Many cities here are associated with some wonderful stories.For example, Bremen is famous for its legend of Bremen Musicians; Cologne is famous for the story of its Dwarfs,and in the city of Hamelin, the legend of the Pied Piper rules.The Pied Piper of Hamelin is considered to be one of the most enduring legendary figures in the world.The story goes like this: In 1284,a man dressed in a multi-coloured coat arrived in Hamelin.He was a rat catcher. He promised to rid the town of rats and plague for a fee of 100 pieces of gold coins. The residents of Hamelin promised to pay him if he succeeded in freeing the town of rats. So the strange visitor took out a pipe and started playing it. Soon, rats came out of houses and started following him. He made sure that each and every rat was out of its hiding place.
Playing his pipe, the man walked straight into the River Weser where the rats plunged after him and drowned. However, when he returned to collect his fee, the residents of Hamelin said they would pay him only one gold coin for his work. Piper left the city in anger and returned to the city on the 26th of June that year.This time he was dressed as a huntsman,wearing a grim countenance and a red hat.While the adults of the town were assembled in the church,he started playing his pipe in the streets. This time, all the children of the town started following him. He led them through the Ostertor gate into the heart of a hill where they all disappeared, except for two children who could not keep pace with the others.Of these two children, one was blind and could not show where the others had gone.The other child could not speak and could not describe what happened.Some say the children, 130 of them,were led into a great cavern and reappeared in Transylvania. Though there is no historical evidence for the legend of Pied Piper, every year from May to September, Hamelin relives this saga in different ways. Open air shows are held on the terrace of the hochzeithaus, a marriage hall. Many people dressed up as Pied Piper roam through the streets along with their pipes. Every Sunday, the church of the city plays shows of the rat trapper with pop figures known as Pied Piper Glockenspiel.
Hamelin is a small city situated on the banks of the River Weser in the centre of Weser Hill Country,about 42 km from Hannover. It is surrounded by moderate hills and boasts of a church,the Haemelschenburg Castle, a celebration hall, a buerger haus and some moderate hotels.The main attraction of the city are its quiet lanes, especially the Osterstrasse, where on both sides of the road, one can see old houses with Fachwerk. These houses are over 500 years old and have pointed roofs with double or triple stories. Though,most of them have opened shops for tourists on the ground floor, the upper block is carved with beautiful brick designs. Osterstrasse is considered to be one of the most beautiful streets in northern Germany. Every Sunday there is a wochenmarkte,weekend market, where one can buy fresh fruits, flowers and household items.The city comes into tourist mode from mid-May to mid-September, which is the summer season. Despite being a tourist destination, Hamelin is quiet and peaceful. Besides food from other countries, one can get to eat typical German food, which consists of potato,meat and vegetables. In Germany,potato is the main source of carbohydrates, instead of rice and bread.While in Germany,a quiet weekend tour of Hamelin is a must, as here you can experience traditional German culture.■


text:
The Boston Tea Party: What happened?
Posted on January 17, 2019. Filed under: Economics, Politics, Revolutionary War, Truth v. Myth | Tags: Benjamin Carp, Body of the People, Boston Tea Party, Coercive Acts, East India Company, John Hancock |
Part 4 of our series on the Boston Tea Party examines the protest itself. We looked last time at the tradition of violence in Boston, which would lead us—and people at the time—to believe that the final protest against the tea waiting in Boston Harbor to be unloaded according to the terms of the Tea Act would be bloody. The people of Boston were exasperated by their battles with the British government over tea, and, as Thomas Jefferson said, "An exasperated people, who feel that they possess power, are not easily restrained within limits strictly regular."
But the Tea Party itself was not violent. Here's how it played out. Like our earlier posts, this one is deeply endebted to Benjamin Carp's fantastic book Defiance of the Patriots: The Boston Tea Party and the Making of America (from which the Jefferson quote comes).
Patriot protesters had developed the habit of gathering at the Old South Meeting House in Boston, where they heard speeches by patriot leaders like Samuel Adams and John Hancock. They called themselves "the Body of the People", and while they had no official power over the colonial legislature, they had become the real power in town. Their meetings were important for two reasons: first, they presented a powerful threat to the Loyalist governor, tax officials, and tea commissioners. Because the Body was not elected, the governor could not control it by dismissing its members. Second, the leaders of the Body realized that, if talk and diplomacy failed, the Body could continue to make public statements of diplomacy and non-violence while authorizing certain of its members to take bolder action on the side.
So the Body passed a resolution saying that "the use of Tea is improper and pernicious," a relatively mild and impotent statement that they hoped official town meetings would honor and turn into law, thus putting pressure on Boston and the governor… while certain of its members cried out "informally" that they would haul the tea ships up from the Harbor to Boston Common and burn them right there [Carp 120]. Members of the Body cheered, but its prudent leaders did not record this sentiment in the official minutes.
Thus when the last political effort to get the tea sent back to England failed, the Body officially dropped the matter. The hundreds of men gathered in Old South heard the leaders officially abandon the attempt to turn back the tea. And then they began to melt away, slipping out the back exits into the night. Fifteen minutes later, the room was surprised by troops of Mohawks with axes.
Of course, these men had met amongst themselves beforehand to decide what course of action to take if the tea ships could not be turned away and sent out of the harbor. Since we cannot name many men with certainty as perpetrators of the Tea Party, it's hard to get a lot of data on how they decided on throwing the tea into the harbor (since, as we saw, other protests were suggested, including burning the tea). But once the plan of boarding the ships and destroying the tea was hatched, things moved quickly. "They determined that it would take a few dozen men with knowledge of how to unload a ship, and so the men who signed on for the task included a mix of traders and craftsmen. Each man would disguise himself as an Indian and swear an oath of secrecy… Everyone agreed on the ground rules: no one would steal or vandalize any property except the tea itself, and not one would commit any violence or mayhem. If the destroyers worked quickly and efficiently, the job would only take two or three hours" [Carp 117].
As these men now gathered back at Old South, the Body tacitly approved what it knew was going to happen. One man remembered that the last thing he heard before heading for the wharf was John Hancock shouting "Let every man do what is right in his own eyes!"
Once at the ships, the men worked like professionals. The commissioners occupying each ship were identified and told to leave on peril of death. They did so. One Captain Bruce asked what the men were going to do. He was told the plan and ordered below decks with his men, and told they would not be harmed. They did so. [Carp 127] Then the "Mohawks" expertly hauled the tea out of the holds, working very quickly considering the huge weight of the tea chests. They knocked off the bindings, smashed the chests, and threw them overboard. Despite the allure of the tea, and the price it would bring in the morning, only two men attempted to steal any. They were instantly stripped of their clothes and beaten, and sent on their way.
The men made as little noise as possible. This was not the raucous rioting of Pope's Day or the attacks on the tea commissioners' homes. This was business, and it had to be done and done quickly before any soldiers discovered the men. It was imperative that the tea be destroyed, because if it was not it would be unloaded the next morning and it would be impossible to stop its distribution, and then Boston would be the town that let the Patriot cause down after the successful rejections and boycotts in New York and Philadelphia.
By 8:00 or 9:00 PM, the party was over. Everyone went home quietly and followed orders to turn out their pants cuffs and socks and shoes and sweep any tea leaves gathered there into the fireplace. In all, about 92,000 pounds of tea—over 46 tons—had been destroyed [Carp 139].
Reaction was swift. The Tea Party was a complete rejection of British rule. Anything less than a severe punishment would be condoning rebellion. That punishment came in the form of the Coercive Acts: the port of Boston was closed to commercial shipping, ruining its economy; Boston was to recompense the East India Company for the total value of the lost tea; the Massachusetts Government Act set in motion the destruction of the popularly elected General Court (all positions in the colonial government would now be appointed by the king); the Administration of Justice act moved trials of government officials to other colonies or to England; and the Quartering Act made housing British soldiers mandatory for all citizens.
Boston had been acting in concert with New York and Philadelphia, but it bore the brunt of the King's wrath all on its own. It's no surprise, then, that the Revolution was kindled in the hearth of Massachusetts. Next time, we'll wrap the series up with reflections on the meaning and impact of the Tea Party today.
Next time: What does the Tea Party mean today?


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Xinjiang's Yili basin in the far west of China, in which the Yining (or Kujiltai) ISL mine sits, is contiguous with the Ili uranium province in Kazakhstan, though the geology is apparently different.
The Eastport Nesting Dinghy is making all the cruisers round here dreamy eyed with envy as I cruise by with my feet up on the lee rail and my hat tipped forward.
gretsch 1960's hardshell case original "no reserve" item number 330131047440 . sold. gretsch 1960's hardshell case original "no reserve"


text:
Ranking the Top 25 First Basemen of the 2022 MLB Season
Joel ReuterNovember 10, 2022
Todd Kirkland/Getty Images
It's time to put a bow on the 2022 MLB season with Bleacher Report's final positional rankings.
Throughout the year, we released monthly updates to our position-by-position power rankings, selecting the top 10 players at each spot. Now it's time to finalize those rankings while expanding the list to the 25 best at each position.
Just like the regular-season rankings, past production and future expectations played no part in deciding the order—this is simply a rundown of the best and brightest of 2022.
To qualify for inclusion, a player simply had to have at least 200 plate appearances. Each player was only included at the position where he played the most innings.
Let's get things started with a rundown of the top 25 first basemen.
G Fiume/Getty Images
25. Carlos Santana, Kansas City Royals/Seattle Mariners
Still productive in his age-36 season, Santana provided his usual mix of power (19 HR) and on-base ability (14.0 BB%) while splitting the season between Kansas City and Seattle. He had a 101 OPS+ with 15 home runs and 39 RBI in 79 games with the Mariners after he was acquired on June 27.
24. Eric Hosmer, San Diego Padres/Boston Red Sox
The Padres finally found a taker for Hosmer at the deadline, flipping him to the Red Sox after he vetoed being included in the Juan Soto blockbuster. He hit .268/.334/.382 for a 108 OPS+ with 27 extra-base hits in 419 plate appearances, and he still has three years remaining on his eight-year, $144 million contract—most of which San Diego is on the hook for.
23. Garrett Cooper, Miami Marlins
Cooper hit .283/.349/.435 with 29 extra-base hits during the first half to earn a surprise All-Star selection, but his production dipped significantly after the break. His OPS dropped 102 points and he hit just .210 with two home runs in 38 games during the second half. The first-half performance was still good enough to earn him a spot on this list.
22. Ji-Man Choi, Tampa Bay Rays
Choi was used almost exclusively against right-handed pitching in 2022, and he hit .233/.341/.388 for a 114 OPS+ with 22 doubles, 11 home runs and 52 RBI in 419 plate appearances. The 31-year-old could be a non-tender casualty for the small-market Tampa Bay Rays this winter.
21. Ryan Mountcastle, Baltimore Orioles
After a 33-homer rookie season in 2021, Mountcastle was once again a productive middle-of-the-order bat for an Orioles team on the rise. He finished second on the club in home runs (22) and RBI (85), though his limited on-base ability (.305 OBP) again undercut his overall value. Improving his walk rate will be the key to his evolution.
Stacy Revere/Getty Images
20. Seth Brown, Oakland Athletics
One of Oakland's few above-average contributors, Brown posted a 116 OPS+ and led the team in home runs (25) and RBI (73). The 30-year-old also added 11 steals in 13 attempts and played passable defense at first base and both corner outfield spots, tallying 1.7 WAR in 150 games.
19. Vinnie Pasquantino, Kansas City Royals
Pasquantino made his MLB debut on June 28 after posting a .931 OPS with 18 home runs and 70 RBI in 73 games at Triple-A Omaha, and he continued to show middle-of-the-order potential in the majors. The 25-year-old had a 135 OPS+ with 10 doubles and 10 home runs in 72 games, and he should be a staple in the Kansas City lineup for the foreseeable future.
18. Jose Miranda, Minnesota Twins
Miranda hit .344/.401/.572 with 30 home runs in 127 games between Double-A and Triple-A in 2021, and a season-ending knee injury to Miguel Sanó opened the door for him to step into an everyday role this year. Playing in the shadow of Julio Rodríguez and other high-profile AL rookies, he posted a 116 OPS+ with 25 doubles, 15 home runs and 66 RBI in 125 games.
17. Joey Meneses, Washington Nationals
After 10 seasons and 894 games in the minors, Meneses finally got his first MLB opportunity when the Juan Soto/Josh Bell blockbuster created a roster void. The 30-year-old rookie hit .324/.367/.563 for a 165 OPS+ with 14 doubles, 13 home runs and 34 RBI in 56 games, and by season's end, he was unquestionably the best player on the Nationals.
16. Rowdy Tellez, Milwaukee Brewers
A burly 6'4", 255-pound slugger, Tellez launched a career-high 35 home runs hitting in the middle of the Milwaukee lineup. His .306 on-base percentage and poor defensive metrics paint him as a one-dimensional player, and while that is more or less the case, he did quietly raise his walk rate from 7.1 to 10.4 percent.
Daniel Shirey/MLB Photos via Getty Images
15. C.J. Cron, Colorado Rockies
Cron was an All-Star during the first half (90 G, .298 BA, .902 OPS, 21 HR, 69 RBI) and a non-factor during the second half (60 G, .197 BA, .604 OPS, 8 HR, 33 RBI), making him one of the tougher players to slot in these rankings. He finished with a 107 OPS+ and 2.1 WAR, enough to land him at the bottom of Tier 2 at the position.
14. Josh Naylor, Cleveland Guardians
Still just 25 years old, Naylor finally stayed healthy for a full season and delivered on the potential that made him a top prospect throughout his time in the minors. In 122 games, he posted a 121 OPS+ with 28 doubles, 20 home runs and 79 RBI, and he spent much of the season protecting José Ramírez out of the cleanup spot in the lineup.
13. Josh Bell, Washington Nationals/San Diego Padres
Bell was a strong candidate for a top-10 spot before he was traded to San Diego at the deadline. He hit .301/.384/.493 for a 153 OPS+ in 103 games prior to the trade but a dismal .192 with a 75 OPS+ in 53 games after he was dealt. He still finished with a 128 OPS+ and 3.0 WAR in a contract year, and now he gets to test the free-agency waters.
12. Rhys Hoskins, Philadelphia Phillies
The longest-tenured position player on the Phillies, Hoskins posted a 122 OPS+ with 33 doubles, 30 home runs and 79 RBI, reaching the 30-homer mark for the first time since his first full season in the majors in 2018. The 29-year-old added six home runs in 17 games during the team's postseason run.
11. Ty France, Seattle Mariners
France proved his 2021 breakout was the real deal with another strong showing in 2022. The 28-year-old posted a 125 OPS+ with 27 doubles, 20 home runs and 83 RBI in a 3.1-WAR season, and he earned his first All-Star selection. With three more years of team control, he will continue to be a key cog in the Seattle offense.
10. Anthony Rizzo, New York Yankees
Mary DeCicco/MLB Photos via Getty Images
After a solid two-month run with the team following a deadline deal with the Chicago Cubs, Anthony Rizzo returned to the New York Yankees on a two-year, $32 million deal that ultimately became a one-year pact when he opted out earlier this week.
The 33-year-old posted a 131 OPS+ and finished a (distant) second on the team with 32 home runs, all while playing his usual stellar defense at first base and posting 2.3 WAR in 130 games.
Despite his age, another multiyear deal likely awaits this offseason, though he will likely be saddled with a qualifying offer from the Yankees now that he has opted out.
9. Matt Olson, Atlanta Braves
Kevin D. Liles/Atlanta Braves/Getty Images
Despite the fact that his OPS+ dropped more than 30 points, Matt Olson still had a rock-solid first season with the Atlanta Braves, successfully filling the void left by the departure of Freddie Freeman.
The 28-year-old Olson played in all 162 games and logged a 122 OPS+ with 44 doubles, 34 home runs and 103 RBI, finishing ninth in the National League with 294 total bases.
It already looks like the Braves got a nice bargain when they signed him to an eight-year, $168 million extension after he was acquired from Oakland in March, and he was a 3.3-WAR player in the first season of that deal.
8. Nathaniel Lowe, Texas Rangers
Steph Chambers/Getty Images
Nathaniel Lowe hit .339/.399/.566 with 15 home runs and 38 RBI in 72 games after the All-Star break, and his .965 OPS during that time trailed only Aaron Judge (1.286) and Yordan Alvarez (.967) among all qualified hitters.
The 27-year-old finished the year hitting .302/.358/.492 for a 141 OPS+, tallying 26 doubles, 27 home runs, 76 RBI and 3.3 WAR in a breakout season for a Texas Rangers team building toward contention.
The six-player deal to acquire him from the Tampa Bay Rays prior to the 2021 season has a chance to go down as one of the better trades the Texas front office has made in recent memory.
7. Christian Walker, Arizona Diamondbacks
Brian Rothmuller/Icon Sportswire via Getty Images
The Arizona Diamondbacks easily could have non-tendered Christian Walker after he hit a punchless .244/.315/.382 with 10 home runs and 0.5 WAR in 115 games during the 2021 season.
They brought him back on a modest $2.6 million salary, and he put together a career year, posting a 126 OPS+ with 25 doubles, 36 home runs and 94 RBI while starting 157 games in the cleanup spot and tallying an impressive 5.1 WAR.
On top of his power production, he also had far and away the best defensive metrics (17 DRS, 14 OAA) of any first baseman. That stellar work was recognized with his first career Gold Glove win as he edged Paul Goldschmidt and Matt Olson for NL honors.
6. Luis Arraez, Minnesota Twins
Michael Reaves/Getty Images
A rare contact-oriented hitter in today's power-driven game, Luis Arraez hit .316 to win the AL batting title, and he did it while putting the ball in play on a whopping 84.6 percent of his plate appearances.
All told, the 25-year-old hit .316/.375/.420 for a 130 OPS+ with 40 extra-base hits, 88 runs scored and 4.4 WAR in 144 games, and he was named to the All-Star team for the first time.
Defensively, he split his time between first base (65 games), second base (41 games), designated hitter (38 games) and third base (7 games). Despite never playing first base in the big leagues before 2022, he was one of the three AL Gold Glove finalists at the position.
5. José Abreu, Chicago White Sox
Thearon W. Henderson/Getty Images
In a down year by his standards from a power perspective, José Abreu was still one of the most productive all-around hitters in the American League.
The 35-year-old batted .304/.378/.446 for a 133 OPS+ with 40 doubles, 15 home runs and 75 RBI, and even though his home run total was only half of what he hit the previous season, he still ranked among the MLB leaders in average exit velocity (93rd percentile), hard-hit rate (97th percentile) and expected slugging (92nd percentile).
After nine seasons with the Chicago White Sox, it sounds like his time with the South Siders is at an end, and he has a chance to be an impact addition to another team's lineup in free agency.
4. Vladimir Guerrero Jr., Toronto Blue Jays
A year after finishing runner-up to Shohei Ohtani in the AL MVP race, Vladimir Guerrero Jr. was once again one of the most productive middle-of-the-order bats in baseball for the Toronto Blue Jays.
The 23-year-old hit .274/.339/.480 for a 132 OPS+, and he filled up the stat sheet with 175 hits, 35 doubles, 32 home runs, 97 RBI, 90 runs scored and he even added a career-high eight steals in 11 attempts.
Defensively, he continued to settle into his new position across the diamond after breaking into the league as a third baseman, and he took a big enough step forward to take home AL Gold Glove honors.
3. Pete Alonso, New York Mets
Elsa/Getty Images
Pete Alonso tied for the MLB lead with 131 RBI, and while that can often be viewed as a team-centric stat rather than a good gauge of a player's individual performance, he hit .300/.424/.675 in 210 plate appearances with runners in scoring position, which speaks to how consistent he was in his role as run producer.
The 27-year-old had a 146 OPS+ and added 40 home runs to go with his gaudy RBI total, and he continues to be one of the most durable players in baseball. He has played in 530 of 546 games over the past four seasons.
He is under club control for two more seasons, but don't be surprised if the Mets front office starts talking extension this offseason.
2. Freddie Freeman, Los Angeles Dodgers
Harry How/Getty Images
It's not always easy to live up to the hype in your first season with a new team after signing a massive contract in free agency, but Freddie Freeman sure made it look that way with the Los Angeles Dodgers in 2022.
After 12 seasons with the Atlanta Braves, he jumped ship and signed a six-year, $162 million deal with the Dodgers and then hit .325/.407/.511 with 21 home runs and 100 RBI.
He also led the NL in hits (199), doubles (47) and runs scored (117), and his 152 OPS+ was his highest over a full season's worth of games since 2017. If St. Louis Cardinals teammates Paul Goldschmidt and Nolan Arenado wind up splitting votes, he has an outside shot at taking home NL MVP honors.
1. Paul Goldschmidt, St. Louis Cardinals
Dylan Buell/Getty Images
After two runner-up finishes in NL MVP voting during his time with the Arizona Diamondbacks and three other top-10 finishes over his career, Paul Goldschmidt is poised to finally take home the hardware next week.
The 35-year-old had a legitimate shot at the NL Triple Crown before he slumped during the final month of the season, but he still hit .317/.404/.578 for an NL-leading 180 OPS+ while tallying 41 doubles, 35 home runs, 115 RBI and 7.8 WAR.
He has two seasons left on his contract, and the next few years will likely determine whether he has a legitimate Hall of Fame case when the time comes. He's not there yet, but he's also showing no signs of slowing down as he enters his late 30s.
All stats courtesy of Baseball Reference, FanGraphs and Baseball Savant.


Section 8e covers reporting requirements which extend to individual persons as well as to companies – which means you must also ensure your employees are aware of their responsibilities under TSCA.
After attending this session with Environmental Health and Safety (EHS) professional Joe Keenan, you will take away an understanding of the TSCA requirements. You will be able to immediately apply the training and knowledge gained in this session to your organization and operations.
Corporate environmental health and safety professionals, etc.


Nuke the fuckers and Syria.
I expected unilateral action by Israel when barry was elected.
I still wouldn't rule it out.
I'm just dumbfounded that so many people in powerful positions are helping this atrocity in the making!
I second the motion to nuke the bastards. And go Israel go because they won't pussyfoot around if we do.
A nuclear Iran is an absolute certainty.
How long it will remain so is entirely up to PM Netanyahu.


text:
package dao

import (
	"database/sql"
	"fmt"
	"strings"
	"time"

	"go-common/app/admin/ep/merlin/model"

	pkgerr "github.com/pkg/errors"
)

const (
	_wildcards = "%"
	_where     = "WHERE"
	_and       = "AND"

	_pathAndPodNamesMappingSQL = "SELECT CONCAT(business_unit, '.', project, '.', app) AS \"path\" , GROUP_CONCAT(pod_name) AS \"pod_names\" FROM machines WHERE status >=0 AND status < 100 AND ctime < %s GROUP BY business_unit, project, app;"
	_nodeSQL                   = "SELECT DISTINCT(machine_id) FROM machine_nodes"
)

// FindExpiredMachineByDay find expired machines.
func (d *Dao) FindExpiredMachineByDay(day int) (ms []*model.Machine, err error) {
	err = pkgerr.WithStack(d.db.Where("status >= 0 AND DATEDIFF(end_time,NOW())>=0 AND DATEDIFF(end_time,NOW())<= ?", day).Find(&ms).Error)
	return
}

// FindExpiredMachine find a day-old machines.
func (d *Dao) FindExpiredMachine() (ms []*model.Machine, err error) {
	err = pkgerr.WithStack(d.db.Where("status >= 0 AND DATEDIFF(NOW(),end_time) = ?", -1).Find(&ms).Error)
	return
}

// QueryMachine query machine.
func (d *Dao) QueryMachine(id int64) (machine *model.Machine, err error) {
	machine = &model.Machine{}
	err = pkgerr.WithStack(d.db.Where("id = ?", id).First(machine).Error)
	return
}

// QueryMachineByName Query Machine By Name.
func (d *Dao) QueryMachineByName(machineName string) (machine *model.Machine, err error) {
	machine = &model.Machine{}
	err = pkgerr.WithStack(d.db.Where("name = ?", machineName).First(machine).Error)
	return
}

// QueryOnlineMachineByName Query Online Machine By Name.
func (d *Dao) QueryOnlineMachineByName(machineName string) (machine *model.Machine, err error) {
	machine = &model.Machine{}
	err = pkgerr.WithStack(d.db.Where("status >=100 and name = ?", machineName).First(machine).Error)
	return
}

// DelMachine delete machine.
func (d *Dao) DelMachine(id int64, username string) (err error) {
	return pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("id = ?", id).Update("status", model.RemovedMachineInMerlin).Update("update_by", username).Error)
}

// HasMachine verify machine name.
func (d *Dao) HasMachine(name string) (b bool, err error) {
	var size int64
	if err = pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("name LIKE ?", name+"-"+_wildcards).Where("status <> ?", model.RemovedMachineInMerlin).Count(&size).Error); err != nil {
		return
	}
	b = size > 0
	return
}

// UpdateMachineStatus update machine status by giving value.
func (d *Dao) UpdateMachineStatus(id int64, status int) error {
	return pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("id = ?", id).Update("status", status).Error)
}

// QueryMachines query machines and update machine in names status to boot.
func (d *Dao) QueryMachines(names []string, qmr *model.QueryMachineRequest) (total int64, machines []*model.Machine, err error) {
	if err = pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("status >= 0 AND status < 100 AND pod_name IN (?)", names).Update("status", model.BootMachineInMerlin).Error); err != nil {
		return
	}
	gDB := d.db.Model(&model.Machine{}).Where("status >= 100 AND status < 300 AND pod_name IN (?) OR (status > -300 AND status <= -200 OR  status >= 0 AND status < 100) AND username = ?", names, qmr.Requester)
	if qmr.Username != "" {
		gDB = gDB.Where("username LIKE ?", qmr.Username+_wildcards)
	}
	if qmr.MachineName != "" {
		gDB = gDB.Where("BINARY name LIKE ?", _wildcards+qmr.MachineName+_wildcards)
	}
	if qmr.BusinessUnit != "" || qmr.Project != "" || qmr.App != "" {
		var (
			nSQL        = _nodeSQL
			logicalWord = _where
		)
		if qmr.BusinessUnit != "" {
			nSQL = fmt.Sprintf("%s %s BINARY business_unit = '%s'", nSQL, logicalWord, qmr.BusinessUnit)
			logicalWord = _and
		}
		if qmr.Project != "" {
			nSQL = fmt.Sprintf("%s %s BINARY project = '%s'", nSQL, logicalWord, qmr.Project)
			logicalWord = _and
		}
		if qmr.App != "" {
			nSQL = fmt.Sprintf("%s %s BINARY app = '%s'", nSQL, logicalWord, qmr.App)
		}
		gDB = gDB.Where("ID IN ( " + nSQL + " )")
	}
	if err = pkgerr.WithStack(gDB.Count(&total).Error); err != nil {
		return
	}
	err = pkgerr.WithStack(gDB.Order("ctime DESC").Offset((qmr.PageNum - 1) * qmr.PageSize).Limit(qmr.PageSize).Find(&machines).Error)
	return
}

// UpdateMachineEndTime update machine end time.
func (d *Dao) UpdateMachineEndTime(id int64, delayStatus int, endTime time.Time) (err error) {
	return pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("id = ?", id).Update("delay_status", delayStatus).Update("end_time", endTime).Error)
}

// UpdateMachineDelayStatus update machine delay status.
func (d *Dao) UpdateMachineDelayStatus(id int64, delayStatus int) (err error) {
	return pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("id = ?", id).Update("delay_status", delayStatus).Error)
}

// QueryPathAndPodNamesMapping query path and pod names map.
func (d *Dao) QueryPathAndPodNamesMapping() (pathAndPodNames map[string][]string, err error) {
	var (
		rows     *sql.Rows
		path     string
		podNames string
	)
	if rows, err = d.db.Raw(fmt.Sprintf(_pathAndPodNamesMappingSQL, d.c.Paas.MachineTimeout)).Rows(); err != nil {
		err = pkgerr.WithStack(err)
		return
	}
	defer rows.Close()
	pathAndPodNames = make(map[string][]string)
	for rows.Next() {
		if err = rows.Scan(&path, &podNames); err != nil {
			return
		}
		pathAndPodNames[path] = strings.Split(podNames, ",")
	}
	return
}

// UpdateMachineStatusByPodNames update machine status by pod names.
func (d *Dao) UpdateMachineStatusByPodNames(podNames []string, target int) (err error) {
	return pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("pod_name IN (?)", podNames).Update("status", target).Error)
}

// UpdateMachineUser Update Machine User By Id.
func (d *Dao) UpdateMachineUser(machineID int64, username string) (err error) {
	return pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("id = ?", machineID).Update("username", username).Error)
}

// QueryMachinesByPodNames query machines by giving pod name slices.
func (d *Dao) QueryMachinesByPodNames(podNames []string) (machines []*model.Machine, err error) {
	err = pkgerr.WithStack(d.db.Model(&model.Machine{}).Where("pod_name IN (?)", podNames).Find(&machines).Error)
	return
}

// InsertMachines insert machines.
func (d *Dao) InsertMachines(u string, gmr *model.GenMachinesRequest, ins []*model.CreateInstance) (err error) {
	var m *model.Machine
	tx := d.db.Begin()
	if err = tx.Error; err != nil {
		return
	}
	for _, in := range ins {
		m = in.ToMachine(u, gmr)
		if err = tx.Create(m).Error; err != nil {
			tx.Rollback()
			return
		}
		for _, n := range gmr.ToMachineNode(m.ID) {
			if err = tx.Create(n).Error; err != nil {
				tx.Rollback()
				return
			}
		}
		if err = tx.Create(m.ToMachineLog()).Error; err != nil {
			tx.Rollback()
			return
		}
	}
	if err = tx.Commit().Error; err != nil {
		tx.Rollback()
	}
	return
}

// QueryMachineInRunning Query Machine In Running
func (d *Dao) QueryMachineInRunning() (ms []*model.Machine, err error) {
	err = d.db.Where("status >= 100").Find(&ms).Error
	return
}

// QueryMachineCount Query Machine Count
func (d *Dao) QueryMachineCount() (total int, err error) {
	err = pkgerr.WithStack(d.db.Model(&model.Machine{}).Count(&total).Error)
	return
}

redpajama_set_name: RedPajamaGithub


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text:
Back to Medical Applications of Particle Accelerators (NPAP MOOC)
Learner Reviews & Feedback for Medical Applications of Particle Accelerators (NPAP MOOC) by Lund University
Hello and welcome to this course! The NPAP - Medical Applications of Accelerators is one out of three courses in the Nordic Particle Accelerator Program (NPAP). Here you will be taken on a tour focusing on the medical applications of particle accelerators. You will see that there are two very important, but different, applications of accelerators in hospitals. The first application concerns radiotherapy of tumours and the other concerns the production of medical nuclides for diagnosis and treatment. Both will be included in this course and described through four modules. The first module offers the basic principles of radiotherapy from a medical and physics point of view. You there learn about the main components of the machines used for radiotherapy and get to know why radiotherapy is important for cancer treatments. The second module guides you through the different types of linear accelerators used in the machines for radiotherapy. It also describes the design of the treatment head. The design is important because it is the settings of the treatment head that determines the dose and the radiated region. It is also in the treatment head where the dose given to the patient is measured. In the third module you are introduced to proton therapy. In this type of therapy protons are first accelerated and then guided down to the tumour by magnets. The machines are considerably larger and more expensive than machines used for radio therapy. The module also offers a description and comparison between different types of accelerators, and explains how the protons interact with tissue. Also ions that are heavier than protons can be used in cancer therapy. This is described in the fourth module, where we also introduce you to the production of medical nuclides. You learn how the nuclides are produces in proton and ion accelerators and how the nuclides come into play at different places in hospitals. Medical nuclides are for instance used in Positron Electron Tomography, PET. Enjoy!...
Amazing course! lectures are short and sweet! this is recommended for medical engineering students, engineering, physics students, and other healthcare students!
The course content is good, nicely explained by video tutorials and notes. Good for beginner and learned about medical physics and its clinical application.
26 - 50 of 52 Reviews for Medical Applications of Particle Accelerators (NPAP MOOC)
By Fernanda G B
Adorei, ótimo curso, os vídeos são bem fáceis e didáticos.
By SaiTejveer S (
It was an enlightening course on medical physics.
By Egem E
Great lectures that attract you into the field.
By Peter N
Great course content - very well laid out
By JOEL B
Inspiring ...Interesting...Exploring...
By jenny M C
It was a very enriching course
By Joshy S
It was really informative.
By Nalini V 1
It's an excellent course .
By Winston A W
Excellent, thank you.
By Yasser R
Well done Course.
By JAYDEEP K
By JEEVARATHINAM S
By SANDRA C V
By Fulvio R F A
By NARAYANASAMY. K
By Phoebe A
Even though the lecturer speaks monotonously, he was still able to deliver and I have gained a deeper understanding of electron linacs . I also got to know about proton and heavy-ion radiotherapy for the first time.
By Nay L K
Thanks for first, i learned from this course the structure and function of accelerator and i have also known difference kind of pronton therapy and how they are produced.
By Anthony P
Informative but the instructor was a bit monotonous. It was a bit hard to engage but I learned a lot about radiotherapy, its potential and its current flaws.
By Ricardo D G U
and keep interest about it
By Alaka B G
Very helpful and intorductory course on heavy ion therapy.
By Rosa P
I like it because it is precise and not very extensive.
By Dr. M D
By A M
There were a lot of errors in the lecture transcripts, and the lecturer's accent was so pronounced that correct transcripts would have been useful for anyone, let alone for someone who needs to rely solely on the transcript. Someone only reading might end up wondering what saxophones have to do with treatment rooms, and what on Earth is prime stalin dose profile... The solutions to the quiz questions were not obtainable from the course materials in many cases, especially the ones with calculations, and while they were mostly basic, to be frank I find it subpar course design to not make sure the material matches to the questions, without making it clear that the course requires the student to find information outside of the course material. The graded quizzes were identical to the practice quizzes, which makes them mindless repetition. Also, because the questions were vague in many cases, it would have been easier to do the practice quizzes with trial and error (unlimited tries) than finding out by googling what the question is about (the English of the questions wasn't always too easy to interpret).
By Amrit B
The contents were good, the quizzes were decent and no disrespect to the professor who taught us, but I felt that he was very robotic and monotonous. the concepts weren't very well explained sometimes (especially in week 3) or maybe it was just hard for me.
By Soham S
The content is excellent and very nicely organized. The videos were great. However for a beginner level course, more explanation of equipment working would've helped greatly


text:
Indiana Jones: Harrison Ford's on-set healt...
Indiana Jones: Harrison Ford's on-set health crisis created one of his most iconic scenes | Films | Entertainment
Jennifer Lopez net worth: Star's fortune as she sings at Joe Biden inauguration day
Published On: Tue, Apr 9th, 2019
Global share rally cools as U.S. turns up trade heat on Europe
FILE PHOTO: Men look at stock quotation boards outside a brokerage in Tokyo, Japan, December 5, 2018. REUTERS/Issei Kato
By Marc Jones
LONDON (Reuters) – April's equities rally risked running out of puff on Tuesday, as a U.S. threat to slap tariffs on hundreds of European goods and expectations of another chunky chop to the IMF's global growth forecasts tested investors' stamina.
Asia had eked out a 8-month high overnight but Europe was left flat after the office of the U.S. Trade Representative sent its proposals to the World Trade Organisation, saying the EU had provided $11 billion worth subsidies to Airbus.
The planemaker' shares dropped as much as 2.5 percent in early deals. Many of its key suppliers lost between 0.7 percent and 1.2 percent, though it could have been worse and most of Europe's big bourses clawed back to level.
Aberdeen Standard Investment's head of global multi-asset strategy, Andrew Milligan, said: "Signals like this just remind people… that the strategic rivalry between the U.S. and other countries is serious and is not going to go away."
The day's other focus was set to be the International Monetary Fund's half-yearly forecasts, which are likely to reinforce the message that trade spats are contributing to slowing the global economy.
The Fund is expected to make quite a sizable cut to its growth number and Germany's benchmark 10-year bond yield stayed just below zero percent on bets interest rates are set to stay extremely low globally.
In the FX market, Sterling nudged higher as UK Prime Minister Theresa May prepared to meet Germany's Angela Merkel and France's Emmanuel Macron to ask for another Brexit delay.
The Australian and Canadian dollars and Norwegian crown and Russian rouble also rose as a surge in oil prices to five-month highs lifted most other commodity-linked currencies too.
Brent, the global benchmark, rose as high as $71.34 a barrel, the highest since November, and by 0850 GMT was up 14 cents at $71.24. U.S. WTI crude also hit a November 2018 high of $64.77 and was up 22 cents at $64.62.
Oil prices – up more than 40 percent this year – have jumped on expectations that global supplies will tighten due to fighting in Libya, OPEC-led cuts and U.S. sanctions against Iran and Venezuela.
"Concerns over the potential squeezing of supply in Libya following the escalation of violence there are adding fresh impetus," analysts at JBC Energy wrote.
(Reporting by Marc Jones; editing by John Stonestreet)


text:
What is a Sloan Point?
by Juliet E. Morrow, ARAS-ASU Research Station
Figure 1. Sloan point excavated from the Sloan site (Photo by J.E. Morrow). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
Named for Frank Sloan of Jonesboro, Arkansas, the Sloan point type is a large, thin biface made sometime between about 12,500 and 11,500 years ago (Figure 1). The Sloan point in Figure 1 is the type specimen which was found at the Sloan Dalton cemetery (3GE94) in Greene County, Arkansas. The site was excavated in 1974 by the Arkansas Archeological Survey. The Sloan point from this world famous site is the widest and longest Dalton biface from the Sloan site assemblage. It is 189.2 mm long, 59.1 mm wide, and 11.1 mm thick. Sloan points and Dalton points were made by hunter-gatherers who moved seasonally across much of the eastern two-thirds of central North America. Many other large Dalton points were also recovered from the Sloan site, but most of these are quite a bit smaller than a Sloan point (Figure 2). The association of a Sloan point with other Dalton points at the Sloan site (3GE94) is the best indicator of this point type's relative age and cultural affiliation.
Figure 2. Dalton points from Sloan site (Photo by Jane Kellett). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
Dalton point technology extends from central Illinois to northeast Arkansas and from the western edge of the Appalachians to central Oklahoma. So far, Sloan points have been found primarily in states bordering the Mississippi River.
Sloan points are not simply large Dalton points, they are unusually large or "hypertrophic" hafted bifaces that probably had symbolic meaning. Sloan points are much wider and longer than the average Dalton point and their overall outline shape is parallel-sided to triangular. The basal concavity is comparatively shallow and the flaking pattern is typically collateral to the midline of the biface over transverse percussion with pressure thinning (see Morrow 1996). They resemble some smaller Dalton points in their overall shape and flaking pattern (Figure 3).
Figure 3. Dalton points, Left: Burlington chert finished point, Right: Pitkin chert late stage preform/pristine finished Dalton point with no haft grinding (Photo by Jane Kellett-ARAS). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
At least two dozen other Sloan points have been found in the Central Mississippi Valley. Most of them are made of white chert that may derive from the Burlington Formation; however, large cobbles of Burlington chert also occur in the Pliocene Upland Complex Gravels of Crowley's Ridge in northeast Arkansas. Dalton people may have preferred Burlington chert because of its color, high quality, and knappability. Knappability refers to the ease with which the stone could be chipped to a desired shape. Research shows Dalton knappers may have preferred white cherts like those from the Burlington and Penters Formations not only for their knappability but also because they were available in large piece sizes. Highly mobile hunter-gatherers selected large piece sizes to make large tools because they have longer use-lives. When large tools break, the fragments can be recycled into new tools. Large tools are like an insurance policy. If a large tool breaks, many kinds of serviceable tools can be made from the fragments. For mobile hunters scattered widely across the landscape, large tools would be better than small tools because of the uncertainties involved in obtaining flint. Sloan bifaces are probably a hold-over from the Clovis era when hypertrophic bifaces were routinely made and cached for future use and also placed into graves, perhaps offered to the gods or spirits. Sloan points may be a material expression of the notion that Dalton groups in different regions could rely on each other in hard times. We know from the archeological record that Dalton foragers gathered, perhaps annually, at special places where Sloan points and other hypertrophic Early Archaic period bifaces have been recovered.
Sloan points, as well as other very large bifaces, have been regarded as ceremonial objects but in addition to any ritual purpose or purposes they served, they were also useful tools. If they were used, either by Dalton people themselves, or by later groups, we don't yet know for what specific tasks they were used or the type of material on which they were used. None of the reported Sloan points exhibit impact fractures so they probably didn't function as spear points. Bones of cervids (elk and deer), fish, and birds recovered from several Dalton sites indicate people were hunting and fishing. Easily processed plant foods like nuts and berries were probably also part of the Dalton diet based on the few professionally excavated Dalton sites where samples of floral and faunal remains were recovered during controlled excavations. It's unlikely, however, that Sloan points were needed to process any of these foods.
Figure 4. Morrow holding cast of Poinsett County Sloan point cast by Pete Bostrom (Photo by Sherry Pruitt, courtesy of the Jonesboro Sun).
One of the reasons why I think Sloan points were possibly used as knives is based on a study I conducted in 2010. I designed a series of experiments using replicated Dalton points on a variety of animal tissues (bone, skin, flesh) to create use-wear that might approximate patterns observed on the Dalton points from the Sloan site (including the Sloan point). Under low power (40 to 130x) I compared use-wear traces on the replicas to the use-wear traces on the Dalton points. I observed polish on the lower portion or haft area as well as rounded and polished lateral margins of the biface blade on the Sloan point (see Figure 1). It is possible, but not likely, that this point was not used and the traces may instead represent manufacturing traces.
Another reason why I think Sloan points could have been used as knives, but not necessarily by the Dalton people who made them, is evidence of knife wear on three probable Sloan point fragments. These include two large point fragments donated to the Survey by two different collectors. One was found near Egypt, Arkansas; it's made of a white chert that could be from the Burlington Formation or from the Pliocene Upland Gravels, the nearest source of which is Crowley's Ridge. The second fragment, made from Pitkin chert, was found in Mississippi County, Arkansas. The Pitkin example exhibits surface fractures suggesting it's been heated, but not necessarily by Dalton people. The third probable Sloan point is also from Mississippi County, Arkansas.
Other Sloan Points
Another Sloan point from Arkansas was found long ago near the town of Fisher. At the time it was in the Floyd Ritter collection, Pete Bostrom made a cast of it (Figures 4, 5, and 6).
Figure 5. Poinsett County Sloan point cast by Pete Bostrom (photo by J. E. Morrow). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
Figure 6. Reverse side of Poinsett County Sloan point cast by Pete Bostrom (Photo by J.E. Morrow). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
In 2013, I documented a very large biface that was found on a terrace of an old slough in Dunklin County, southeast Missouri (Figures 7 and 8). Like Sloan points it is made of Burlington chert, it's heavily ground along the lateral margins, and appears to have use-wear traces. The haft grinding and the outline form suggest that it's not a Sloan point, but rather a very large Dalton point. The ability to reexamine an artifact periodically allows you to see and learn more than if you examine it on only one occasion. It took me three trips to Montana to feel confident about the data I collected on the Anzick artifacts and I'm sure that if I saw them again, I'd see things I hadn't noticed in 1999, 2000 and 2001.
Figure 7. Sketch and notes of a very large Dalton point from Dunklin County, Missouri on old fluted point form (Photo by J.E. Morrow).
Figure 8. Large Dalton point from Dunklin County, Missouri (photo by J. E. Morrow). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
A recent Sloan point I photographed is from site 11AX267 in Alexander county, Illinois where a number of hypertrophic bifaces have been found (Figure 9, above). It's a truly spectacular specimen. I have not measured it but as you can see by the scale in the photograph it is over 300 mm, maximum blade width is 87.4 mm, and base width is 72.8 mm.
Figure 9. Sloan point from the Olive Branch site (11AX267), southern Illinois (photo by J. E. Morrow). Copyright Arkansas Archeological Survey. Do not reproduce without permission.
One of the reasons for my current focus on Sloan points is my curiosity about the Dalton culture and technology. Stylistically, it's very different from Clovis, Folsom, and Gainey and other Paleoindian stone working technologies, but organizationally, Dalton stone working technology is not all that different from their ancestors. Their technology was designed to help them gather resources that would help them make it through the winter, ensure that they kept in contact with their kin in other regions, and find suitable mates. With Sloan points, they appear to be propitiating the spirits by burying them ceremoniously at special places like the Olive Branch site. This propitiation may have been practiced in accordance with a seasonal round that brought people from different regions together at sacred places on the landscape when certain heavenly bodies such as planets, stars, constellations, and galaxies like the Milky Way were in observable alignments.
More about Sloan from the Arkansas Archeological Survey
The Sloan Site (50 Moments in Survey History)
The Sloan Point from 3GE94 in NE Arkansas (Artifact of the Month series)
The Sloan Site Photo Gallery - a supplement to the 2018 reprint of Sloan: A Paleoindian Dalton Cemetery in Arkansas by Dan F. Morse
References for Additional Reading about Sloan points and Dalton Culture
Morrow, Juliet E.
2016 Clovis Evidence for Paleoindian Spirituality and Ritual Behavior: Large Thin Bifaces and Other Sacred Objects from Clovis and Other Late Pleistocene-Early Holocene Cultural Contexts. In Research, Preservation, and Communication, Honoring Dr. Thomas J. Green on his Retirement from the Arkansas Archeological Survey. Research Series 67:18–65. Arkansas Archeological Survey, Fayetteville.
2010 The Sloan Dalton site (3GE94) Assemblage Revisited: Chipped-stone Raw Material Procurement and Use in the Cache Basin. The Missouri Archeologist 71:1–40. Available at: https://www.academia.edu/18262867/The_Sloan_Dalton_Site_3GE94_Assemblage_Revisited_Chipped-Stone_Raw_Material_Procurement_and_Use_in_the_Cache_Basin
The Dalton Culture http://www.encyclopediaofarkansas.net/encyclopedia/entry-detail.aspx?search=1&entryID=545
1996 The Organization of Early Paleoindian Lithic Technology in the Confluence Region of the Mississippi, Illinois, and Missouri Rivers. Ph.D. dissertation, Department of Anthropology, Washington University, St. Louis.
Perino, Gregory
1985 Selected Preforms, Points and Knives of the North American Indians. Volume 1. Points and Barbs Press. Idabel, Oklahoma.
Morse, Dan F.
1997 Sloan: A Paleoindian Dalton Cemetery. Smithsonian Institution Press, Washington, D.C.
Morse, Dan F., and Phyllis A. Morse
1983 The Archaeology of the Central Mississippi Valley. Academic Press, New York.
Stuckey, Sarah D., and Juliet E. Morrow
2013 Sourcing Burlington Formation Chert: Implications for Long Distance Procurement and Exchange. The Quarry #10:20–29.


Friends appear to be few and far between as Arab Spring snuffs out regional partners for Israel.
The Egyptian revolution that toppled Hosni Mubarak had particular resonance in Israel.
The country lost one of its closest allies in the region, and a loyal partner in security. And now, with the Muslim Brotherhood poised to make great gains in the elections, Israel's longstanding peace treaty with Egypt is again coming into question.
Al Jazeera's Tony Birtley reports from Sinai, Egypt.


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New Computational Strategy Finds Brain Tumor-Shrinking Molecules
by Zara JethaniPosted at 4:31 PM
Computer modeling identifies first-ever molecule to inhibit a transient cellular event that drives glioblastoma, and the molecule shrinks glioblastoma in mice.
The optimal treatment for most gliomas is maximal surgical removal followed by radiation therapy and chemotherapy. However, patients with glioblastoma, a type of malignant glioma, unfortunately usually survive less than 15 months following diagnosis. Since there are no effective treatments for this disease, we have created a new computational strategy to search for molecules that could be developed into glioblastoma drugs. In mouse models of human glioblastoma, one molecule we found shrank the average tumor size by half.
The newly discovered molecule works against glioblastoma by wedging itself in the temporary interface between two proteins whose binding is essential for the tumor's survival and growth. This study is the first to demonstrate successful inhibition of this type of protein, known as a transcription factor.
Transcription factors control which genes are turned "on" or "off" at any given time. For most people, transcription factors labor ceaselessly in a highly orchestrated system. In glioblastoma, one misfiring transcription factor called OLIG2 keeps cell growth and survival genes "on" when they shouldn't be, leading to quick-growing tumors. In order to work, transcription factors must buddy up, with two binding to each other and to the DNA at same time. If any of these associations are disrupted, the transcription factor is inhibited.
In this study, our research team aimed to disrupt the OLIG2 buddy system as a potential treatment for glioblastoma. Based on the known structure of related transcription factors, we developed a computational strategy to search databases of 3D molecular structures for those small molecules that might engage the hotspot between two OLIG2 transcription factors.
With this approach, we identified a few molecules that were tested for their ability to kill glioblastoma tumors. The most effective of these candidate drug molecules, called SKOG102, shrank human glioblastoma tumors grown in mouse models by an average of 50 percent.
While the initial pre-clinical findings are promising, it will be several years before a potential glioblastoma therapy can be tested in humans. SKOG102 must first undergo detailed pharmacodynamic, biophysical and mechanistic studies in order to better understand its efficacy and possible toxicity.
This research was conducted at the UC San Diego, Moores Cancer Center, as well as the San Diego Supercomputer Center and Department of Neurosciences at UC San Diego and appears in the October 30, 2015 issue of Oncotarget.
Santosh Kesari MD PhD, is
the Director of Neuro-oncology, Professor of Neurosciences and Chair, Department of Translational Neuro-oncology and Neuro-therapeutics at the John Wayne Cancer Institute at Providence Saint John's Health Center. Dr. Kesari's clinical team at the Pacific Brain Tumor Center sees
patients with all types of brain cancers and neurological disorders and conducts leading-edge clinical trials in the areas of immunotherapy
and biomarker-based therapies. In the John Wayne Cancer Institute's laboratories, he and his research team study cancer stem cells, their roles in the formation of brain tumors, and develop new drugs for brain cancers.
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7 Everyday Questions about Cervical Dystonia
9 Everyday Questions about Pituitary Tumors and Pituitary Adenomas
The Pacific Neuroscience Institute (PNI) at Providence Saint John's Health Center is devoted to the care of patients with a wide spectrum of neurological and cranial disorders including: brain tumors, skull base tumors and pituitary tumors; stroke and related neurovascular diseases; adult hydrocephalus; vision and hearing disorders; facial pain syndromes; movement disorders as well as sinonasal tumors and related disorders.
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