Twin sisters Elena and Marina Lukyanchuk, hold a Bachelor of Arts in visual communications from American University (Dubai). Born in Moscow, Russia, they have moved to Dubai in 2004 to commence their undergraduate studies.
Conditional Spaces, Unconditional Entities School of Visual Arts, (New York, USA, June 2009) Basically Human: Conditional Spaces, Unconditional Entities Empty Quarter, Dubai, UAE and several others.
With a solid background in contemporary arts, photography and fashion, Elena and Marina founded The Factory Production Studio in 2015. They have lived, studied and worked in Dubai for the last 13 years.
The sisters are committed professionals managing a successful and rapidly growing business.


Someone once said that pulse of any neighborhood can be measured by the activity in its beauty salons. Whether the statement is accurate or not, the fact is that beauty salons form a staple of any community; generally focusing on providing hair care and nail treatment services to the local residents. Beauty salons serve an additional purpose – they are designed to draw people together and provide an inviting environment for them to stay.
Beauty salons often feature open layout concept punctuated by individual stylist stations and sections devoted to specific services. Appropriately designed lighting is an integral part of creating an environment in which customers will feel comfortable and the stylists will have ample light to do their job.
At Highlights Chicago we have the expertise to design lighting solutions that create soothing ambiance and provide adequate light throughout the space. Atmosphere and functionality are the primary focus of beauty salon lighting system; however, other elements such as environmental safety and cost efficiency are also important. Through using fixtures that are environmentally friendly or made from recycled materials and use LED bulbs, we help beauty salon owners cut costs without sacrificing quality of lighting. That is especially important because beauty salons use considerable amount of energy each day therefore even minor incremental changes result in substantial savings.


text:
Q: Why Does "The Loop" Survey Have an Option for Under 18 in Question 6? This is not a question of "Why does The Loop Survey ask about age?" That has been asked elsewhere.
This is not a question of "Why can't users under 18 take The Loop Survey?" That has been asked elsewhere.

The first question in The Loop Survey is:

*

*
*

*To continue, please confirm that you are at least 18 years of age.

If you answer "I am under 18", the survey ends.
If you answer "I am at least 18 years old", the survey continues.
Question # 6 is:

*What is your age in years? (optional)

The first response listed is:

Under 18

Selecting "Under 18" does not abort the Survey.
Was there no thought at all put into the Survey questions?
Is this a "trick question" to find all the teenagers using Stack Overflow while pretending to not want to talk to them?

A: My guess is the 18+ requirement came down from on high (legal) late in the process and thus wasn't considered in the original design of the survey. Having been added at the end, the age category wasn't revisited to remove the redundant option.
This is substantiated by Catija's explaination in her answer to the question of why the loop requires respondents to be 18 or older:

I asked about this when we were rolling it out and the response I got
  is that we consider this to be user research, which, for legal
  purposes, we restrict to users who are 18 and up in order to opt in.

It's plausible that the data science team designing these surveys was not aware of this requirement when designing them.

A: Typically you want complete coverage for a demographics question, but because this is after a screener, yes, you don't need the under 18 option for question 6.
It might be used an attention check, but it's also possible the survey author didn't think through the branching logic. When rushed, I've made similar mistakes.
It's one of the reasons you should always field test a survey first. Considering the other errors, it seems like they skipped this step.

redpajama_set_name: RedPajamaStackExchange


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Denmark's Minkstermination
by Qinwei Zhuang
The decision announced by the Danish prime minister, Mette Frederiksen, on November 4th to destroy all minks in the northern country is projected to result in the destruction of more than 15 million minks. The Danish government claimed their decision was supported by evidence that a mutated variant of SARS-CoV-2 spread among minks had infected humans and that this variant could interfere with future vaccine effectiveness. However, the severity of the mink viral strain is still under debate. Slaughtering all minks nationwide, with its far reaching implications for the whole fur industry, has been described as both aggressive and overly cautious.
While causing surprise all over the world and leading to concerns of the severity of the astonishing move, the spread of SARS-CoV-2 among farmed mink did not happen overnight. The first reported cases of COVID among farmed minks in Denmark occurred on June 17th and led to more than 5,000 minks being euthanized. On September 18th, Denmark's infectious disease research institute, the Statens Serum Instituton, alerted that the mutated virus from mink had formed trans-infection chains in humans and warned that these virus mutations could attenuate community immunity. Urged to take immediate action to minimize the risk of wider spreading of the new virus mutant, on November 4th the Danish prime minister announced the order to kill all minks nation-wide.
Strain tracing and variant calling
One natural question to ask is how virus strains are being traced, especially for mutations that might have unwanted potential to boost transmission and/or lethality. Examples from an earlier study1 focusing on SARS Coronavirus-2 variant tracing during the early outbreak of COVID-19 patients in northern Germany illustrate bioinformatics' role in virus strain tracing during this pandemic. Specifically, the techniques applied include variant calling and comparative analysis of single nucleotide polymorphisms (SNPs). Genomic data was collected via metagenomic RNA-sequencing and amplicon-sequencing before subsequent variant calling identified frequently observed clusters of SNPs. The mutations that enhanced the replication and transmission of the virus are more likely to take precedence and therefore serve as signatures for identifying popularized strains (Figure 1). Strain clusters are critical for evaluating the dynamics of virus mutation, for diagnostic and therapeutic purposes as well as to inform policies aiming to contain the spread of the virus.
Clustering of viral variants of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) sequences recovered from the index patient, patient 1, patient 2 and 19 SARS-CoV-2 sequences from respiratory swabs collected at the same time period in comparison to the reference sequence, NC_045,521. Nucleotide positions are indicated at the bottom. Only variants with sufficient coverage (>10) and single nucleotide polymorphism (SNP) present in more than 33% of all reads and in at least one sample are included. I-III summarizes sequence patterns as defined by SNPs. The frequency of variants is indicated by the heat map ranging from grey (reference), yellow to dark blue (variant). The quality score per individual site is indicated at the top. * indicates members within one family. Sampling dates are indicated on the right with the sampling date of the cases in the index cluster labelled in red.
1. Potential Overinterpretation
Comparative genomics has been a common practice in detecting similarities among and differences between samples. However, one bigger challenge following variant discovery is evaluating the significance or potential impact of SARS-Cov-2 mutations on pandemic containment efforts. Scientists express skepticism upon the claim that mutations in one of the clusters identified from Denmark's farm minks could attenuate the efficacy of vaccines under active development. More scrutinized trials are needed to evaluate the risks of the newly popularized strain interfering with vaccination efforts.
2. Lack of universal guidelines
Risky incidents of intra- and interspecies transmissions of SARS-Cov-2 have been captured and spotlighted. However, universal guidelines are still needed to prevent interspecies transmission between humans and other natural hosts. In similar emergencies, detailed criteria will be immeasurably valuable for supporting or halting such extreme public health measures as euthanizing large herds of animals. Despite enormous costs, overcaution can still be greatly beneficial, when well guided.
1. Pfefferle, S., Günther, T., Kobbe, R., Czech-Sioli, M., Nörz, D., Santer, R., Oh, J., Kluge, S., Oestereich, L., Peldschus, K. and Indenbirken, D., 2020. SARS Coronavirus-2 variant tracing within the first Coronavirus Disease 19 clusters in northern Germany. Clinical Microbiology and Infection.
COVID-19 didn't cancel these summer internships
by David Brownlee
With economies locked down this past summer and companies reluctant to hire, for many students, internship opportunities looked rather grim. Despite the shutdown of the McGill campus, the Canadian Center for Computational Genomics (C3G) shifted gears and revved up for a summer of working from home internships.
For Solomia Yanishevsky to complete her Master's of Health Bioinformatics at Dalhousie University, she either had to do an internship or write a thesis. Desiring practical experience, Solomia expanded her job search beyond Halifax, NS and landed at the Montreal node of C3G. After many companies backed out of their hiring intentions, of the 20 students in her program, she was one of only four to find an internship position. Over the summer, Solomia worked with the Data Team to generate artificial FHIR datasets to successfully test a data ingestion algorithm. She also mapped the mCODE data standard to C3G's Phenopacket metadata service to broaden its compatibility. As part of Genome Canada's Canadian COVID Genomics Network (CanCOGen) project, Solomia worked on integrating live COVID-19 data elements from six different sources into a cohesive framework, a project that is as ongoing as the global health pandemic. Seeing her work put to use and understanding how it integrated into the bigger picture, Solomia embraced the responsibility. She found the work environment highly collaborative and engaging. Her coworkers were welcoming and her mentor was patient to her learning process.
Not every Queen's University computer engineering student can tell the difference between DNA and RNA, but
Soulaine Theocharides is the exception. Currently pursuing a secondary degree in biology, her summer work here at McGill (Queen's University's great rival) occupied the space at the intersection of the two fields. Working alongside the TechDev Team, Soulaine used computing clusters, Unix and Python to develop a searchable organizational structure for massive epigenomic datasets. Her project integrated databases and file hierarchies with genetic analysis pipelines. Soulaine rigorously documented her resilient data organizational structure so that it survives well beyond her internship.
McGill software engineering student Sebastian Ballesteros didn't let his absence of genomic experience interfere with his summer. Instead, the novelty of genetics was a strong motivational factor for him. Leveraging previous internships working with computer graphics, Sebastian developed an online tool to visualize genomic variations as part of the Bento platform. He also transformed complicated genomic policy maps into a privacy assessment tool named D-Path (Data Privacy Assessment Tool) which allows data stewards worldwide to easily comply with regional regulations governing genetic data storage and use. Despite living in the McGill ghetto only a few blocks away from the C3G office, his internship was carried out entirely online. Though initially difficult to get a feel for his coworkers and associations, Sebastian found remote work good preparation for his current semester which is being taught entirely online. He loves Montreal's unique personality, multi-cultural diversity, bilingualism and latin flair. With its strong university focus, good population density and available housing, he wouldn't live in any other Canadian city.
After his school, Collège Ahuntsic, cancelled all their biotechnology laboratory technique internships, Étienne Collette's summer was uncertain. During the previous semester at school, C3G Services Team Bioinformatics Manager François Lefebvre and C3G Bioinformatics Specialist Emmanuel Gonzalez had been guest lecturers, introducing his class to the computational side of bioinformatics. About to complete his DEC, during the three months when school was restricted to online theory classes, Étienne used the spare time to teach himself the C programming language. One thing led to another and a three week placement at C3G turned into a four month internship where Étienne engaged in no less than six different bioinformatic projects. Coming from an interdisciplinary background, the variety and concurrency were appreciated and stimulating. Along the way, he was supported by responsive feedback from the Services Team and daily updates with François. Étienne found purpose in the real-world detective work required by genuinely unsolved bioinformatic problems. He has just started studying biochemistry at l'Université de Montréal where he intends to specialize in genetics.
C3G and the Bourque Lab at McGill University routinely hire students for summer internships. Many continue to work part-time beyond the summer as they complete their studies. We are a bilingual lab with people from many backgrounds, countries and skill-sets represented. Summer internships are posted around December with applications accepted until mid-February. Sometimes internships happen unexpectedly too. If you, or someone you know, is interested in learning beyond the classroom, drop us a line. See what happens, eh?
https://www.computationalgenomics.ca/internships/
Making New Discoveries Using Public Data
by Audrey Baguette
Every research project is composed of three key elements: a question to answer, the analyzes to perform and the data to use. Often, that last component is limiting. Indeed, producing new data is expensive and sometimes even time-consuming. Thankfully, a solution exists in the form of huge libraries accessible with a few clicks: public data.
Advantages of Using Public Data
Databases are full of useful data covering various techniques, technologies, and organisms. For example, the Encyclopedia of DNA Elements (ENCODE) harbors more than 17000 datasets on human, mouse, worm and fly, from RNA sequencing to whole-genome sequencing through protein binding1,2. Not only is public data easily accessible and free, it may also be stored in its raw and pre-processed form, requiring less time and costs in subsequent analyses (do not forget to perform quality controls first!) While more bioinformatics-inclined papers often use pre-existing datasets to compare tools, they are otherwise greatly overlooked, either because we assume all that could be done with it has been done or because it does not have the exiting spark of novelty. But datasets may have been analyzed using only one angle and could still hold many secrets, even if there are a few years old. Additionally, the ever-growing performance of new algorithms may permit to extract information that was hidden in the data before. For those reasons, it can be valuable to re-analyse public data and this can lead to new discoveries.
How to Use Public Data Efficient
Public databases contain information about many diseases, cell types, organisms and techniques, but it is still limited to what has been explored before. One must thus slightly change his way to approach data in order to find a new angle to analyze. Thus, instead of the typical "formulate question -> how to answer the question -> produce data" workflow, the preparation requires to scout the existing datasets to find some that have a potential for new discoveries. The analyzes have to be centered around the available data rather than the opposite.
Example of New Discovery from "Old" Data
1- Formulate the research question
For my research project, I wanted to study the relationship between transcription and 3D conformation of the DNA in the nuclear space. Various studies tried to explore this before, some of the earliest dating from 19933, but the mechanism is complex and there are still many unknowns.
2- Explore datasets
One of the most common diseases in human is lung cancer. Because of its prevalence and mortality rate, it is also one of the most studied diseases and thus the data produced is widely available. I thus chose to use the A549 cell line, a lung cancer cell line. Various data types were generated from it (RNA-seq, ChIP-seq, Hi-C), permitting to explore both the transcription events and the architecture in these cells. Moreover, being a cell line, it should have less cell-to-cell variability than cells coming from a patient biopsy.
3- Adapt the angle of exploration
As many other studies, including the ones from with the data I used was produced, tried to explore the inter-relation between transcription and 3D folding, a new angle had to be found. A literature review showed there were still many unknowns regarding the different types of boundaries limiting co-regulation between genes
4- Discover!
A striking tendency that was seen while exploring the data was that the relative orientation of genes seems to influence their probability of co-regulation. We thus proposed a model stating simple "rules" that affect the probability of co-regulation of two genes in A549 cells (Figure 1). In other words, Genes located on the same strand have a very high chance of co-regulation, as the transcription machinery could just slide from one gene to the other. When genes are located on different strands, there is less chance of co-regulation as the machinery would have to completely un-bind, then re-bind to the opposite strand. The change of strand thus introduces a type of co-regulation boundary. Finally, stronger boundaries that have been described before, such as TAD boundaries or the co-localization of Cohesin and CTCF, disrupt more strongly the probability of co-regulation. The discovery of tendencies that serve as a base to the proposed model have all been made using public data.
Figure 1: (A) Same-strand genes are very likely to be co-expressed, as the RNA pol II just needs to continue its path along the strand. Divergent and convergent genes are less likely to be co-expressed, as the RNA pol II would needs to detach and reattach itself to go from one gene to the other. (B) When genes are separated by a barrier (CTCF and Cohesin or TAD boundary), there is complete disruption of co-expression.
1. The ENCODE Project Consortium. An Integrated Encyclopedia of DNA Elements in the Human Genome. Nature 489, 57–74 (2012).
2. Davis, C. A. et al. The Encyclopedia of DNA elements (ENCODE): data portal update. Nucleic Acids Research 46, D794–D801 (2018).
3. Jackson, D. A., Hassan, A. B., Errington, R. J. & Cook, P. R. Visualization of focal sites of transcription within human nuclei. EMBO J 12, 1059–1065 (1993).
Posted September 2020
Disambiguating mixed-species of graft samples
by Senthilkumar Kailasam
As a Bioinformatician, often I get to work with PDX cancer samples. I've recently been reading about samples containing genome admixture, and was revisiting strategies that we commonly use for analyzing these biological data. Presented here is a summary of the existing software tools used for this purpose.
What are Xenografts?
Studying and understanding cancer is very challenging, and animal model systems help in addressing some of the common research bottlenecks. Mouse harboring human cancer cells, also known as Patient-derived xenograft models (PDX), are an excellent model system available to researchers. A small number of cancer cells collected from a patient are injected into an immunocompromised mouse, which grow to form tumors. PDX systems provide a controlled platform to study tumor biology and are especially useful for testing chemotherapeutic approaches.
Technical issue with xenograft samples
The grafted sample obtained from these mouse tumors can be subjected to NGS for genomics and transcriptomics studies. Despite meticulous efforts, it is difficult to prevent contamination of the graft samples with the host (mouse) stromal tissue, and the sequencing obtained is usually contaminated with host DNAs and RNAs. These contaminations could hinder correct interpretation of the data. Removing reads of host origin before downstream analysis is becomes essential to ensuring accurate conclusions.
What are the methods available?
Various algorithms exist to separate host-derived reads from the rest of the sample. Almost all methods require that the input is in two are more BAM files: one aligned to the host genome and other aligned to the graft genome. The type of aligner used also hugely influences the choice of algorithm. I was able to find five well documented software packages. Most of these algorithm compare the quality of read alignment and then categorises the reads to either host or graft. If ambiguous the read is discarded. Some of the key features of these packages are highlighted in the table. (Table 1)
Package/software Name
Compatible Aligner
Sargasso Bowtie2, STAR Multispecies Custom filtering by threshold Yes [1]
Xenosplit Subread, Bowtie2, Subjunc, TopHat2, BWA and STAR Maximum two species Goodness of mapping scores No [2]
Disambiguate Hisat2, TopHat, BWA and STAR Maximum two species No [3]
XenoCP BWA Maximum two species Cloud-based Yes [4]
I tried all three of the four of these packages (XenoCP omitted) in an active project. I had selected a sample dataset that had issues with poor read alignment to reference genome (GRch38). The reason I chose this dataset was to see if the unaligned reads are of host origin! But that was not the case for this dataset. I used the number reads recovered (assigned as graft-origin) as a parameter to compare the tools. Sargosso and xenosplit perform very similarly and are stringent in assigning the reads to graft. Disambiguate, the oldest program of those tried, gave slight improvement compared to standard reference genome-based alignment alone. In the future, I plan to compare these five packages using a synthetic dataset with known portion of mouse and human reads. Until then, Sargasso and xenosplit seem promising if you are interested in specificity and not sensitivity.
raw_reads 187, 299, 238 140,927,692 328,021,530 342,910,322
trimmed_reads 187,126,248 140,809,146 327,809,782 342,667,064
sargasso_Human
(%) 36,469,134
(19.49) 261,686
(0.19) 55,689,176
(16.99) 18,074,244
xenosplit_Human
disambiguate_Human
GRCh38(unique)
Qiu, J., et al., Mixed-species RNA-seq for elucidation of non-cell-autonomous control of gene transcription. Nature Protocols, 2018. 13(10): p. 2176-2199.
Giner, G. and A. Lun, https://github.com/goknurginer/XenoSplit. 2019.
Ahdesmaki, M.J., et al., Disambiguate: An open-source application for disambiguating two species in next generation sequencing data from grafted samples. F1000Res, 2016. 5: p. 2741.
Rusch, M., et al., XenoCP: Cloud-based BAM cleansing tool for RNA and DNA from Xenograft. bioRxiv, 2020: p. 843250.
Posted August 2020.
The ANCHOR pipeline
ANCHOR is a high-resolution metagenomics pipeline, the result of a multi-disciplinary collaboration between C3G and researchers at Institut de recherche en biologie végétale (IRBV) at Université de Montreal. Published in 2019 in the journal Environmental Microbiology, the pipeline demonstrated unprecedented accuracy in its characterization of microbiome samples [1]. Dr. Emmanuel Gonzalez, co-creator of the pipeline and the metagenomics specialist at C3G was motivated by his observation that existing tools were not performing well on real-life datasets. "C3G's strategy towards microbiome analysis had been to run commonly used pipelines, but the resolution would sometimes deliver foggy results that made the interpretation challenging. When I joined C3G, another pipeline was buzzing, using a machine learning algorithm to remove sequence noise – a characteristic of metagenomics samples. That was quite the thing back in 2015. It was clever, light and incredibly fast, except… I happened to realize that its accuracy was dropping significantly with real-world experiments involving multiple samples."
In designing ANCHOR, Dr Gonzalez and co-creator Dr. Nicholas Brereton had resolved that the tool would be written with a strong focus on understanding the biology of metagenomics experiments. Dr Gonzalez recalls that "before I even began writing down any code, we sat down together and set up some ground rules for this new pipeline, based on the respect towards the inherent complexity of any biological system and a reassessment of the capacity and ability of technical advances to handle biological complexity. I think this starting point is what made ANCHOR stand out amidst similar metagenomic pipelines. For example, our first rule went absolutely against the trend: let's not modify sequences!"
Confined habitats
In the publication introducing ANCHOR, Drs Gonzalez and Brereton reanalysed metagenomic data from surface swabs within the International Space Station (ISS). The ISS experiment had originally used the Qiime pipeline and the conclusions of the analysis were that no differences were present when comparing the surface microbial ecosystems of the Destiny (US laboratory) and Harmony (crew sleeping quarters) modules. The reanalysis using ANCHOR substantially improved the scale of data capture as well as the accuracy and resolution of the findings, providing microbial classifications at the level of individual species. The reanalysis not only led to exciting novel discoveries regarding the ISS environment but also fundamentally changed the major conclusion of the experiment, with significant differences clearly identified between the modules (Figure 1). These significant differences detected by ANCHOR included increases in microbiome bacteria associated with the laboratory animals within the Destiny module, such as Helicobacter typhlonius, a species endemic to rodent research laboratories on earth [1].
Figure 1. ISS Destiny and Harmony Module differential abundance. Significantly differentially abundant taxa, their ISS location and illustrations indicating their known associations.
Presented as part of the scientific article, ANCHOR was used to reanalyse metagenomic data from surface swabs within the International Space Station (ISS). The experiment originally used the Qiime pipeline and the conclusions of the analysis were that no differences were present when comparing the surface microbial ecosystems of the Destiny (US laboratory) and Harmony (crew sleeping quarters) modules. The reanalysis substantially improved the scale of data capture as well as the accuracy and resolution of the findings, now at microbial species-level. "The researchers from the first analysis did a great job, but the pipeline they used limited their ability to analyse what was inside the with precision" adds Emmanuel. The reanalysis not only led to exciting novel discoveries regarding the ISS environment but also fundamentally changed the major conclusion of the experiment, with significant differences clearly identified between the modules (Figure 1). These significant differences included increases in microbiome bacteria associated with the laboratory animals within the Destiny module, such as Helicobacter typhlonius, a species endemic to rodent research laboratories on earth(1).
Human microbiome health
The ANCHOR pipeline was designed to improve data accuracy in high complexity real-world systems, and its applicability quickly moved from the ISS to terrestrial health concerns. "We transitioned this approach directly to the field of human health later in 2019 after Dr. Amir Minerbi, a medical doctor from the Alan Edwards Pain Management Unit, showed great interest to use our pipeline to characterise the bacterial microbiota of women suffering of fibromyalgia", says Emmanuel. That collaboration led to the discovery of the first microbiome association to chronic pain by comparative analysis of the gut microbiomes of healthy women with fibromyalgia patients [2]. In patients with fibromyalgia, significant increases of species such as Clostridium scindens and Butyricicoccus desmolans, which are bottlenecks in secondary bile production (via 7α-dehydrogenase activity) as well as bacterial derived androgens (20α- and 20β-hydroxysteroid dehydrogenase activity) which may interact with the endocrine system (Figure 2). These are important discoveries in the field which has sparked a new research direction in the pain field and the research has already been recognised around the world.
Long-term Space Travel
At the end of 2019, the team behind ANCHOR responded to a grant call made by the Canadian Space Agency to promote projects on Health & Life Science data and sample mining. They proposed to analyse astronaut microbiomes using improved metagenomics to study the impact of long-term space travel upon astronaut health. "We're grateful to the Canadian Space Agency for giving us the chance to apply high resolution microbiome analysis within the space sciences again and particularly excited to see whether there is an observable impact of long term confinement on the microbiome health of astronauts.
Les microbes de la Station spatiale internationale
1. Gonzalez E, Pitre F, Brereton N. ANCHOR: A 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples. Environmental Microbiology. 2019.
2. Minerbi A, Gonzalez E, Brereton NJ, Anjarkouchian A, Dewar K, Fitzcharles M-A, et al. Altered microbiome composition in individuals with fibromyalgia. Pain. 2019.
ANCHOR: a 16S rRNA gene amplicon pipeline for microbial analysis of multiple environmental samples
Learn more about ANCHOR
Author: Emmanuel Gonzalez
Science Quebec article: Read now
Posted: July 22 2020
The Biobanque Québécoise de la COVID-19 (BQC19) is a province-wide biobank which mission is to provide high-quality data and samples to the scientific and medical community in order to better understand, combat and limit the impact of the coronavirus disease 2019 (COVID-19).
This initiative is led by Dr. Vincent Mooser, Director of its Executive Committee, and a Canada Research Excellence Chair in Genomic Medicine of the Faculty of Medicine at McGill University. It was made possible with the contribution and involvement of inter-institutional and multidisciplinary teams including McGill Genome Center and C3G.
The BQC19 is available to researchers across the country and around the world. Since having access to high-quality data and samples is essential to win the war with the COVID-19 pandemic, the biobank is committed to the principles of Open Science to make all data accessible to qualified researchers.
Visit: bqc19.ca
Mcgill Article read more
COVID-19 Resources Canada
C3G has been part of a group of volunteer researchers, students, activists and web developers, led by Guillaume Bourque of McGill University and Tara Moriarty of the University of Toronto, who created COVID-19 Resources Canada a website to facilitate the sharing of information, expertise and resources in the fight against COVID-19. The group aims to "Serve as a reliable source of information and expertise for COVID-19 research in Canada; Support & facilitate coordination of Canadian COVID-19 research efforts; Support COVID-19 capacity-building in public health, research and grassroots initiatives." The initiatives include a database of volunteers, a tool for sharing reagents used by clinicians and researchers; a compilation of all active Canadian research into COVID-19 and funding opportunities, among others.
visit COVID-19 Resources Canada
Covid-19 updates at C3G
We would like to provide a quick update amidst the coronavirus pandemic. While our host institutions (McGill University, SickKids Toronto) have put various measures in place to ensure the safety of our staff, our platform remains fully operational and available to support genomics research. Researchers should therefore not hesitate to contact us and inquire about our analysis and data management services, seek help to plan experiments, get support for a grant application or request free consultations with our bioinformaticians.
If your lab is conducting or planning to conduct COVID-19 related genomics research, our platform can help. Contact us at info@c3g.ca.
Please remember to stay safe and healthy.
C3G Team
Infant Glioma: Characterizing the landscape of genetic drivers and their clinical impact
Recently published in Nature Communications, this paper presents work by members of the C3G Toronto node that integrates genomic and transcriptomic analyses to assess the molecular and clinical features of infant glioma patients. Examining single nucleotide variants, changes in copy number, fusion formation and other transcriptomic analyses revealed three clinical glioma subgroups in infants, each with distinct genetic drivers, locations in the brain and responses to treatment. Gliomas in infants have substantially different treatment outcomes compared to those that occur in children and adults, yet little is understood about the molecular basis of these differences. This paper gives a comprehensive molecular analysis of infant gliomas to helps to ascertain the biological mechanisms driving their oncogenesis and to help guide future diagnostics and treatment approaches for these patients.
Methylation signatures investigations
The C3G Toronto node has also been involved in two projects to investigate methylation signatures for specific conditions. We have recently published a manuscript in BMC Medical Genomics in which we describe specific DNA methylation signatures for Nicolaides-Baraitser syndrome (NBS), a rare childhood condition that affects physical features and intellectual ability (Chater-Diehl et al., 2019). We showed that specific methylation patterns are associated with pathogenic variants of the NBS causal gene, SMARCA2, which encodes the catalytic domain of a chromatin remodeling complex. We have also identified DNA methylation signatures associated with autism spectrum disorder risk loci, which has been recently published in Clinical Epigenetics (Siu et al., 2019). We show that methylation signatures can be used to identify and distinguish individuals with specific autism-associated mutations and can help determine if specific gene variants are pathogenic or benign to improve autism diagnostics.
Genetics & Genomics Analysis Platform: version 2
We are pleased to announce that the new version of GenAP is now available [HERE]. This release offers a completely re engineered platform that leverages Cloud resources at Compute Canada, and will eventually be deployed as well on other HPC resources. It already offers 2 types of applications: Data Hubs (as in GenAP1), a new graphical "File Browser" allowing files transfer to and from your workspaces,. A new Galaxy application, including up-to-date tools and pipelines, will eventually be added.
ForCasT: a fully integrated and open source pipeline to design CRISPR mutagenesis experiments
ForCas Tool (ForCasT) is a comprehensive tool for the design, evaluation and collection of CRISPR/Cas9 guide RNAs and primers. Using robust parameters, it generates guide RNAs for target loci, assesses their quality for any potential off-target effects and designs associated primers. The results are then stored in a local database that serves as a shared resource for users within a research team, and is constantly being updated to reflect the quality of guides and primers based on additional computational and wet-lab results. ForCasT is a single tool that research teams from various fields of biology can use to build and maintain a collection guide RNAs and primers for Cas-mediated genome editing that are suited to their specific needs. It is currently available as a web-app and as a Dockerized version, and can be found at https://github.com/ ccmbioinfo/CasCADe
Last summer was a productive summer for our members in terms of publications !
Read more about highlighted publications
GenPipes: an open-source framework for
distributed and scalable genomic analyses
It started in June with the publication of our beloved GenPipes framework and set of NGS data analysis pipelines in GigaScience. We use these pipelines on a daily basis for data production and routine analysis and hope the community will find it useful. While GenPipes is the product of several years of teamwork, kudos to co-first authors Mathieu Bourgey and Rola Dali who worked very hard to get this long-awaited paper out!
Altered microbiome composition in individuals with fibromyalgia
This summer has also been very special for C3G's metagenome specialist Emmanuel Gonzalez with a publication in Pain highlighting a strong potential link between the microbiome and fibromyalgia, a terrible and elusive disorder affecting a large fraction of the population. This study drew quite a nice amount of media attention, notably from the
Montreal Gazette and the CBC. We are very proud to say that through Emmanuel, C3G provided first-rate analysis services for experimental design, species identification, statistical analysis, machine learning and finally for working hand-in-hand with Drs. Minerbi and Brereton on biological interpretation. Importantly, Emmanuel's applied ANCHOR here, a method he also
published earlier this year, which enables the identification of microbial species at a resolution higher than for other common 16S sequencing data analysis methods.
Altered differentiation is central to HIV-specific CD4+ T cell dysfunction in progressive disease
Another noteworthy publication to which C3G members contributed as authors was published in Nature Immunology this summer. An important focus of the study was the comparison of HIV-specific CD4 T-cells subpopulations from patients who have undergone antiretroviral therapy and patients who spontaneously suppress HIV viral load below detectable limits (a.k.a. elite controller patients). This comparison contributes to an understanding of why viral control is lost once antiretrovial activity therapy is interrupted.
GSoC 2019 is over!
Again this year, C3G was a Google Summer of Code organization. For people unfamiliar with it, GSoC is in Google's own words: " a global program that matches students up with open source, free software and technology-related organizations to write code and get paid to do it! "
We would like to thank participating students this year for their contributions.
Jiahuang Lin (TBD) – Human history and genome evolution
Konstantinos Kyriakidis (AUTh) – Batchtools for Compute Canada
Madhav Vats (IIIT Delhi) – Flowchart creator for GenPipes
Pranav Tharoor (MAHE) – MiCM Project Match
SriHarshitha Ayyalasomayajula (KMIT) – GenPipes single-cell pipeline
There is a huge library of common bioinformatics software available on Compute Canada resources via the modules maintained by C3G staff and distributed via the CernVM-File System (CVMFS). Despite the breadth of the C3G CVMFS library, there may be times when using the provided software isn't ideal.
you might want to use software that we haven't yet made available via CVMFS and you don't want to repeatedly install it at each HPC facility you might want to guarantee comparability of results by running exactly the same software stack on Compute Canada, your workstation, or on infrastructure from a cloud provider such as Amazon Web Services or Google Cloud there is a more recent version of the software already available in a container. Listings of existing images are available from community efforts such as biocontainers, but also might be made built directly from the source repository.In circumstances such as these, containers offer an excellent solution by packaging up your software and its dependencies into a single image that contains all the software needed for a particular analysis or workflow.
The process for running containerized software on Compute Canada can be described in three steps:
Ensure singularity is available
Download a container
Run your containerized software
Step 1: Ensure singularity is available
At all Compute Canada facilities, singularity is available as a module. Loading the module is as simple as running:
If you're running singularity on your linux laptop or workstation, download instructions are available here.
Step 2: Download a container
Many software stacks are already available as Docker images at repositories such as Docker Hub or Quay.io. Unfortunately, running Docker on shared clusters introduces potential security vulnerabilities. Fortunately for us, Singularity can use Docker images to build new singularity containers. For example, let's say that we wanted to run the genometools suite. The biocontainers repository shows me that the latests version (1.5.10) is available at quay.io/repository/biocontainers/genometools-genometools as a Docker image. To download the image to my Compute Canada instance, I can run "singularity pull":
This produces the singularity image "sif" file in the current directory.
Step 3: Run your containerized software
To run the genome tools suite from inside the new container, prepend your command with "singularity exec ":
That's it! You have a perfectly reproducible software stack running without needing to worry about installation or dependencies.
Next Steps and Getting Help
As you might imagine, there are plenty of details we don't have time to cover in this short blog post. If you'd like to learn more, or if you're having trouble, there are plenty of ways to find help.
The Compute Canada wiki has an excellent page on running containers on their infrastructure (en/fr)
The Singularity docs are the definitive guide
The C3G has a weekly open door session to which you are welcome to bring questions about containers and reproducible bioinformatics analyses.
Why better Data Sharing means better health Care
The future of personalized medicine is dependent on data sharing, according to Yann Joly, Research Director of the Centre of Genomics and Policies; and Guillaume Bourque, Director of the Canadian Centre for Computational Genomics.
Using big data techniques to analyze the function of human genes is already helping develop treatments tailored to individual patients. The more data researchers can access from across the world, the better chances of treating even rare diseases. But privacy and consent regulations differ by country, making sharing this information across borders slow and frustrating.

redpajama_set_name: RedPajamaCommonCrawl


text:
HomeNorth Florida folk singer to perform at Ormond Beach Regional Public Library
North Florida folk singer to perform at Ormond Beach Regional Public Library
Post Date:September 18, 2014
ORMOND BEACH -- Bob Patterson will share the folklore and songs of Florida during a free performance from 2 to 3 p.m. Wednesday, Oct. 1, at the Ormond Beach Regional Library, 30 S. Beach St. Patterson is a professional singer, songwriter and storyteller with more than 40 years of experience performing at clubs and festivals across the nation.
Pstterson co-founded the Gamble Rogers Folk Festival and received the 2011 Mother Earth and Fellow Man Award in recognition for his gifts to folk culture. He moved to Florida in 1969 and became an integral part of the Florida folk music scene. He has been featured at the Florida Folk Festival for more than 40 years, performing 12-string guitar and song writing workshops, storytelling, and music concerts.
Patterson opened for Emmy Lou Harris at the 2005 event and was chosen as one of the Legacy Performers for the 2006-2009 festivals. His songs have been recognized by the American Song Festival and The Best of Florida Song Writing Competition. His song 'Lullabye of the Rivers' was used in the documentary film about the Ocklawaha River. He had his book 'Forgotten Tales of Florida' published by the History Press.
North Florida gfolk singer Bob Patterson opened for Emmy Lou Harris at the 2005 event and was chosen as one of the Legacy Performers for the 2006-2009 festivals. His songs have been recognized by the American Song Festival and The Best of Florida Song Writing Competition. His song 'Lullabye of the Rivers' was used in the documentary film about the Ocklawaha River. He had his book 'Forgotten Tales of Florida' published by the History Press.
The program is sponsored by the Friends of the Library. For more information, please call the Ormond Beach Regional Library at 386-676-4191, ext. 21084. To learn about other upcoming library programs, please visit www.volusialibrary.org.
Headline Surfer® is the award-winning 24/7 internet newspaper serving the greater Daytona Beach-Orlando metro area via HeadlineSurfer.com.


Need a valuable domain name for your business? We specialize in domain name trading and have acquired some premium domains. Please take a look at our domain name portfolio and if something catches your eye, don't hesitate to contact us.
We launched a new website.. Check out BlackRice.com for information about healthy, nutritious and full of antioxidants black rice.


The great thing about Pages is how it's both a word processor and so much more than a word processor at the same time. For example, the Shapes menu gives you access to a selection of shapes to be dropped right into your document. Using the Inspector tool, you can customize the shape's color, border, orientation, and even add a drop shadow.
But it gets even better than that! With some creativity imbued along with the tools available, you can actually make some pretty neat works of art. Said works of art could even be submitted to online contests, such as the one we're hosting right now.
Here's the deal: the tutorial below will help you draw your masterpiece with Pages. Take a screenshot and then send it in!
I'll walk you through the basic steps for making fanciful designs. Have you ever seen user-submitted Mii's for the Wii? I often scratch my head, wondering "How did they do that with the few things they're given?" You need to adopt the same mentality with Pages. Push it as far as you can take it. Use punctuation for facial features, incorporate text, use borders as part of your subject.
When thinking of something to draw, try imagining it as the different shapes Pages offers. Try rotating the shapes to fit your needs. This can be done with the Inspector tool. You'll become real familiar with this guy. Click on the blue "i" in the menu (or option-command-i) and then select the Metrics tool (ruler icon). Click on the rotate dial and turn the shape until it's where you need it.
Also, when placing shapes, you can always right click on overlapping shapes to either send them back or bring them forward (think of pieces of paper physically layered on top of each other. How would you want them to be layered?).
Once you have all the pieces in place, go through and determine how the outlines of the shapes will play into your drawing. Do you want the shapes to stand out, or would you rather they meld together? Since I have multiple shapes in play for different parts of my face, I removed the lines. In the Graphic Inspector (square and circle icon) you can change the line settings or remove it all together.
Notice that I left the eyes outlined so that I could actually find them in the sea of green.
Here's where the fun begins. Now you can start to give your drawing some life by replacing the lime green with colors. Again, using the Graphic Inspector, you have a variety of options with Fill. Play around with the different options until you find what will work best. You can even change the colors of the shape's borders to blend them.
Here's where you add the finishing touches. The pen tool in the Shapes menu can help add those fine lines. Drop shadow can be used to add a dramatic effect. I have a fever, and the only cure is more drop shadow!
I added a white box with no border at the bottom of my picture to even out the arms and torso. I then placed a larger "frame" box around my picture and sent it to the back. Finally, I used a line shape to bridge the area covered by the white box. By using the jagged border, it kind of blends them together. Then I finished with a gradient I liked.
If you don't know about shift-command-4 then you're missing out on a wonderful tool. Hitting this key combination will turn your pointer into a crosshair. Click and drag it over the area you'd like to capture, and it will instantly take a screenshot and save it on the desktop as a .png file. You can rename the file and also turn it into a .jpg extension if you need to. Not happy with the area you selected? Hit Esc before letting go of the mouse and the crosshair goes away. Watch out that you don't capture your Pages cursor in the shot.
We at The Real Mac Genius want to see how far can YOU take drawing with Pages? The contest is simple: "draw" anything you'd like using just the shapes in Pages. Draw your favorite Apple product, a self-portrait, or even your favorite Smurf! Take a screenshot, and e-mail it to me at: [email protected], with "PAGES CONTEST" in the subject line. Please note: NO clip art or photos can be incorporated into the drawing. Basically, don't bring anything into Pages. This will help keep the drawing focused on what Pages can do.
So, what's it all about, Alfie? Well, we have two cool prizes to give away, thanks to Targus.
2nd place: Prize detail to come shortly.
You must be 18+ years of age and reside within the 48 contiguous United States. One entry per person. Final entries due by Saturday, May 28 at 11:59 PM EST. No entries received after this time will be considered. Winners will be selected based on creativity, design, and adherence to the rule of not importing any clip art or photographs. Winners will be notified by June 1st. Good luck!


Note: Atlanta has left the league and Arizona not signed up.
George - lets hope this game is less atrocious than the actual game! I'm free Sunday, Monday or Tuesday evening after 7.30 if that's ok?
@bigjimmyaston wrote: George - lets hope this game is less atrocious than the actual game! I'm free Sunday, Monday or Tuesday evening after 7.30 if that's ok?
I thought the game was quite exciting James! I thought PIT was the better team, but that was because our offense was so atrocious that it couldn't take advantage of all the turnovers. Overtime was a nightmare. I see the league officials have now said the call on Garrett was wrong - the one where PIT would have had to have a FG try and instead got a 1st down and then scored a TD. The Americans hate a tie, I know, but not losing made a pleasant change for me.
My choice would be Tuesday night if possible - 6:30 onwards - earlier the better.
Blitz my friend when's ok for you?
Danny...can you play after advance Saturday?
Cardinals, can u play Monday 7pm?
geordie when can you play bruh?
Can you play tomorrow evening? I can play from 6 pm UK time.
@GeordieAlfie wrote: Can you play tomorrow evening? I can play from 6 pm UK time.
Still waiting on your time confirmation. I had forgotten I am just about to head off to Felixstowe this morning, which is a bit of a lick from down here, so my orginal 6:30 request might be unachievable. Could we say 7:30 or 7:45?
Are we meant to be doing game reports again?
@Veeebs wrote: Are we meant to be doing game reports again?


text:
Home Christian news Circumcision saved life of Christian under threat from terrorists
ex-atheist
Circumcision saved life of Christian under threat from terrorists
By Michael Ashcraft —
At age 10, Ruslan became a decided atheist after his father, immigrating from Azerbaijan with the family, dumped his mother and married another woman.
"At the time, my mom was so distraught over this, she stopped going to this Armenian Orthodox church where we found a lot of community," he says on a video on his YouTube channel. "I was 10, 11 or 12, and I was literally convinced that there was no God. I was saying, 'I'm an atheist,' at a very young age."
But when Ruslan got to high school, he was torn between girls: one was Christian, the other was Jehovah's Witness. He decided to settle the dispute of whether Jesus was God by studying. He read The Case for Christ by Lee Strobel and the encyclopedic New Evidence that Demands a Verdict by Josh McDowell.
The verdict came in.
"I — based on a very intellectual rational experience — came to faith," he says. "My faith wasn't hinged upon an experience. It hinged on the evidence that Jesus was God and He resurrected from the death."
Ruslan and his son Levi
Ruslan Karaoglanov was born in Baku, Azerbaijan to a Russian mother who had been adopted by an Armenian family and an Armenian father. As an infant in the 1980s, he contracted an acute urinary tract infection, and a doctor at a remote clinic on the Caspian Sea performed a circumcision to save his life.
Five years later, Muslim extremists fanned out through the region to massacre Christian men and boys. Toting automatic weapons, rebels fighting the Soviet Army very nearly killed Ruslan, but his mom argued they were Muslims and showed her son's circumcision as proof (in that region of the world, Christians do not usually circumcise while Muslims do).
"No! No! No!" Marina shouted in Russian, as narrated by Christianity Today. "We're not Armenians. Look, my son is circumcised!"
The ruse worked.
The reign of terror didn't abate, and finally the family applied for visas to America on the basis of religious persecution. They settled in San Diego in 1990.
Little Ruslan spoke only Russian and was one of just five a few "white" kids mixed with "black and brown" youngsters at school. His apartment complex and community had roughly the same ratio.
So while he studied English, Ruslan also learned "basketball, break dancing, graffiti and rap," he wrote to God Reports via Instagram DM. "My experience with the black community is they tend to be very gracious and welcoming of outsiders. Specifically black church folk. I've never felt out of place or anything. Always the opposite."
Ruslan free-styled with his friends from age 10 and performed at open mic night by age 12. He bought as many hip hop CDs as he could and started gravitating towards the gang culture of the hip hop in that era. For attempting to break in to a house, he was arrested and put on probation at age 12.
As part of his probation, he was required to do community service, so he decided to perform it at a church where a lady named Charee, an ex convict who converted radically to Christ, attended. He cleaned the church but also heard the Word. People kept prophesying to him: "You're going to do things for the Lord."
Afterwards, his mom still worried and wondered how to help her son escape the bad influences, so she moved to San Marcos, to the immediate north of San Diego. Ruslan got better grades, stayed out of trouble and stayed in the rap game. "Yo, you're really dope," friends told him repeatedly.
"I was super into basketball and thought I was going to play for the NBA. In my sophomore year, I got cut from my JV basketball team" at Vista High School, Ruslan says on a video. "Ever since then, I made the mental switch that I was going to take music more seriously. I started entering all the talent shows. I won second place in our high school's battle of the bands in 2001."
He went to Cal State San Marcos and worked, but music was always his primary passion. He staged events and helped produce local artists.
In 2010, Ruslan met Beleaf, who was deejaying at the time. The two formed the group thebreax and released a remix each week, three mixtapes and two albums. The production led Ruslan to found Kings Dream Entertainment in 2012 to develop and release other artists.
Ruslan released a solo album Do For One in 2015 and followed it up with Americana the next year. He quit his job and went full time into music. In August 2017, he released Indie Jones, and followed it up with Indie Jones II in January 2018. Indie Jones III is on its way.
Ruslan signed Jon Keith and Paul Russell to Kings Dream Ent. and released a joint album with Russell called Via Tex in 2018.
With his wife, Monette, and son, Levi.
Ruslan has won praise for his work.
"He's a white guy with a really black sound," says secular artist Murs, a friend of Ruslan, on Rapzilla. "In any genre, there hasn't been that white guy who can pull off what he's pulling off sonically — where you hear it and you don't hear color. His music is very soulful, very urban. It's authentic."
Ruslan starting dating his soon-to-be wife, Monette, fresh out of high school after they re-met at The Movement Church in San Marcos (they knew each other in high school). They've now been married 10 years ago and have a son, Levi, age 5. He credits his wife (not the same girl who got him reading about the deity of Christ) with helping him break through into success as an artist.
"My wife was super encouraging. We underestimate how significant the right spouse is for developing your career and helping you grow as a person and supporting your dreams and your vision," Ruslan says. "My wife has been super supportive."
He's found success, not crazy like Lecrae or Bizzle, but solid six figure gross for the last four years. He's non-stop. Music, production, YouTube, videos, Instagram, concerts, push it, push it, push it.
Ruslan's best ever? "I got the Juice" with the now-disbanded Dream Junkies collective.
"It's a Dream Junkie song, so we're not gonna mention that lol," he wrote.
Read about other Christian hip hop artists by clicking: 1K Phew – Aaron Cole — Ada Betsabé – Andy Mineo – Benjamin Broadway — Bizzle – Canon – Cass – Datin – Flame – Gawvi – HeeSun Lee – Jackie Hill-Perry – Jarry Manna — JGivens – Joey Vantes — John Givez – KB – Lecrae – Lil T Tyler Brasel– MC Jin – NF – nobigdyl. – Propaganda – Ray Emmanuel – Ruslan – Sevin – S.O. — Social Club Misfits – Steven Malcolm – Tedashii – Tobe Nwigwe – Trip Lee – Wande Isola – WhatUpRG — YB
And secular rappers who have come to Christ (at least to some degree): Chance the Rapper — Kanye West – Kendrick Lamar – No Malice — Snoop Dogg
And an overview article about the state of affairs in CHH: Christian Hip Hop in Controversy.
Michael Ashcraft is CEO of Cuisine Natural which sells bamboo steamers on Amazon. Click on the link to buy one if you are interested.
Beleaf
Dream Junkies
Jon Keith
Kings Dream Entertainment
Paul Russell
rusian christian testimony
rusian karaoglanov religion
Previous article'Seven Secrets of the Newborn' offers sound advice to young parents
Next article'Black Widow' immersed herself in witchcraft
Michael Ashcraft
http://thelighthousechristianacademy.com
Street kid fought with dogs for food
Pastor banned from prison ministry after speaking against Islamic extremism
Chilling dream brought salvation in his sleep


text:
namespace CGoGN
{

namespace SCHNApps
{

Dialog_Surface_NormalEstimation::Dialog_Surface_NormalEstimation(SCHNApps* s) :
    m_schnapps(s),
    m_selectedMap(NULL)
{
    setupUi(this);

    connect(m_schnapps, SIGNAL(mapAdded(MapHandlerGen*)), this, SLOT(addMapToList(MapHandlerGen*)));
    connect(m_schnapps, SIGNAL(mapRemoved(MapHandlerGen*)), this, SLOT(removeMapFromList(MapHandlerGen*)));

    connect(list_maps, SIGNAL(itemSelectionChanged()), this, SLOT(selectedMapChanged()));

    foreach(MapHandlerGen* map, m_schnapps->getMapSet().values())
        list_maps->addItem(map->getName());
}

void Dialog_Surface_NormalEstimation::selectedMapChanged()
{
    if(m_selectedMap)
        disconnect(m_selectedMap, SIGNAL(attributeAdded(unsigned int, const QString&)), this, SLOT(addAttributeToList(unsigned int, const QString&)));

    QList<QListWidgetItem*> currentItems = list_maps->selectedItems();
    if(!currentItems.empty())
    {
        combo_positionAttribute->clear();

        const QString& mapname = currentItems[0]->text();
        MapHandlerGen* mh = m_schnapps->getMap(mapname);

        QString vec3TypeName = QString::fromStdString(nameOfType(PFP2::VEC3()));

        unsigned int j = 0;
        const AttributeSet& attribs = mh->getAttributeSet(VERTEX);
        for(AttributeSet::const_iterator i = attribs.constBegin(); i != attribs.constEnd(); ++i)
        {
            if(i.value() == vec3TypeName)
            {
                combo_positionAttribute->addItem(i.key());
                ++j;
            }
        }

        m_selectedMap = mh;
        connect(m_selectedMap, SIGNAL(attributeAdded(unsigned int, const QString&)), this, SLOT(addAttributeToList(unsigned int, const QString&)));
    }
    else
        m_selectedMap = NULL;
}

void Dialog_Surface_NormalEstimation::addMapToList(MapHandlerGen* map)
{
    list_maps->addItem(map->getName());
}

void Dialog_Surface_NormalEstimation::removeMapFromList(MapHandlerGen* map)
{
    QList<QListWidgetItem*> items = list_maps->findItems(map->getName(), Qt::MatchExactly);
    if(!items.empty())
        delete items[0];

    if(m_selectedMap == map)
    {
        disconnect(m_selectedMap, SIGNAL(attributeAdded(unsigned int, const QString&)), this, SLOT(addAttributeToList(unsigned int, const QString&)));
        m_selectedMap = NULL;
    }
}

void Dialog_Surface_NormalEstimation::addAttributeToList(unsigned int orbit, const QString& nameAttr)
{
    QString vec3TypeName = QString::fromStdString(nameOfType(PFP2::VEC3()));

    const QString& typeAttr = m_selectedMap->getAttributeTypeName(orbit, nameAttr);

    if(typeAttr == vec3TypeName)
    {
        combo_positionAttribute->addItem(nameAttr);
    }
}

} // namespace SCHNApps

} // namespace CGoGN

redpajama_set_name: RedPajamaGithub


text:
Registered Trademarks
Corporate Organisation
Mr. Chua Beng Kuang,
Mr. Chua Beng Kuang is our Executive Chairman and one of our founders. He is primarily in charge of the overall management, including developing and steering corporate plans, business directions and strategies for the Group. He has over 31 years of experience within the marine industry. He led the management in pursuing the Group's mission and objectives and has been instrumental to our growth.
Mr. Chua Meng Hua,
Mr. Chua Meng Hua is our Managing Director and one of our founders. He oversees the overall administrative, safety and operational systems, including developing and steering plans and directions for the Group. He has over 19 years of experience within the marine industry.
Mr. Low Wee Siong, Lead Independent Director
Chairman, Audit Committee
Member, Remuneration Committee
Member, Nominating Committee
Mr. Low Wee Siong was appointed as our Independent Director on 19 May 2017. He is also a Director of Wong Tan & Molly Lim LLC. Mr. Low focuses on capital markets and mergers and acquisitions work. He has substantial experience in initial public offerings, reverse takeovers, takeovers, rights issues, structured securities issues, acquisitions, and disposals. As a chartered accountant and former investment banker, he understands and appreciates the financial and accounting considerations of transactions. Mr. Low is also experienced in cross border work, involving Malaysia, Indonesia and China jurisdictions. He has been named amongst the most influential lawyers aged 40 and under in Singapore by Singapore Business Review.
Mr. Low Wee Siong holds degrees in law and accountancy from the National University of Singapore and the Nanyang Technological University respectively.
Mr. Goh Chee Wee, Independent Director
Chairman, Nominating Committee
Member, Audit Committee
Mr. Goh Chee Wee was first appointed as our Independent Director on 30 August 2004 and was last re-elected on 19 April 2013. He is also a director of Chailease Holding Company Ltd, Chip Eng Seng Corporation Ltd, King Wan Corporation Ltd, Sinotel Technologies Ltd, Stamford Tyres Corporation Ltd and Sin Ghee Huat Corporation Ltd, all listed companies.
Mr. Goh was formerly a Member of Parliament and Minister of State for Trade and Industry, Labour and Communications. He was the Group Managing Director and Chief Executive Officer of Comfort Group Ltd until 2003.
Mr. Goh holds a Bachelor of Science (First Class Honours) degree and a Diploma in Business Administration from the then University of Singapore and a Master of Science (Engineering) degree from the University of Wisconsin, USA.
Mr. Lum Kin Wah, Independent Director
Chairman, Remuneration Committee
Mr Lum has more than 40 years of experience in the maritime industry in various roles ranging from an apprentice to general manager and director in companies including Keppel Shipyard subsidiary (Keppel Philippines) and PT Pan-United Shipyard Indonesia. He was also the managing director of Nexus Engineering Pte Ltd, a member of the Labroy Engineering Group. He is a Chartered Engineer registered in the UK, a member of the Society of Naval Architects and Marine Engineers in Singapore.
Mr Lum led the expansion, development and layout planning of PT Batamec Shipyard from a pure repair yard into a modern new building yard with track records of some of the most sophisticated offshore support vessels in the market. In 1991, he was tasked to spearhead the development of PT. Pan-United Shipyard Indonesia from a greenfield site to a fully functional new building and repair shipyard.
TERMS & CONDITIONS | DISCLAIMER	| TERMS OF USE	| PRIVACY STATEMENT	| SITEMAP Copyrights © 2012 Beng Kuang Marine Limited. All rights reserved.


text:
Uzhhorod National University, Ukraine
Ukraine is considered a renowned destination to study MBBS abroad due to the excellent quality of education and the affordable fee structure that the country highlights. The government also provide additional scholarships and loans to aid the students financial throughout the duration of the course.
Additionally, while studying, students could also enjoy the diverse culture, and explore the mesmerising locations to fill their life with a store full of memorable moments.
University at a Glance
Here are some of the factors that make Uzhhorod National University, Ukraine an attractive option for medical aspirants.
World Ranking – 5592
Country Ranking – 36
Uzhhorod National University, Ukraine was established in 1945, and since achieved much recognition including the status of autonomy in the Carpathian, Ukraine. The university showcases the best panel of teaching staffs and education traditions one could only imagine, and it is presently the largest higher education institute in the entire Carpathian region.
Uzhhorod National University, Ukraine has employed a total of 1275 staff, 146 doctors of sciences, 698 candidates of sciences, 11 honoured scientists, and 14 honoured doctors of Ukraine.
Accreditation and Recognition of Uzhhorod National University
The different organization that has approved Uzhhorod National University, Ukraine includes the following;
World Health Organization (WHO);
National Medical Commission (NMC);
US Education Department
General Counsel of Medicine of Great Britain;
And, UNESCO.
Over 13,000 students study MBBS at Uzhhorod National University, Ukraine. The university trains specialists in different fields of qualification including 53 bachelor degrees, and 101 specialities. Uzhhorod National University, Ukraine also ranks 36th among all the other universities in Ukraine.
Faculties / Departments at Uzhhorod National University
The different faculties offered by Uzhhorod National University, Ukraine are as listed below.
Faculty of Geography
Faculty of Healthcare and Physical Education
Faculty of Foreign Philology
Faculty of History and International Relations
Faculty of International Economic Relations
Faculty of Postgraduate and Pre-university Education
Faculty of Tourism and International Communication
Faculty of Philology
Faculty of Law Ukrainian-Hungarian Educational Institute Natural sciences and Humanities College Department of Military Training
Why Study MBBS In Uzhhorod National University, Ukraine
With a history of over 6 decades, Uzhhorod National University, Ukraine is one of the leading higher educational institutes in Ukraine. The university has grown to be quite popular among medical aspirants from all around the world due to the numerous benefits it offers including the quality education and practical exposure to the latest technological developments in the field of medical science.
Uzhhorod National University, Ukraine has also gained a 4th level of accreditation and the courses and programs offered are in accordance with the European standards of education.
The important perks offered by Uzhhorod National University, Ukraine to students include the following:
Uzhhorod National University, Ukraine offers a brilliant environment that promotes education.
The entire course is offered in the English language and the admission procedure is devoid of any entrance examination.
Uzhhorod National University, Ukraine cooperates with nearly 90 esteemed universities from around the globe.
Top-notch education at the lowest possible fee.
Duration of MBBS in Uzhhorod National University
The duration of MBBS at Uzhhorod National University, Ukraine is 6 years where the first 5 years are dedicated to theoretical studies and the last one year to clinical practice/ internship. During the second and third year, students can opt to take part in practical researches as well.
Intake for MBBS Admission in Uzhhorod National University
The admission for MBBS undergraduate and postgraduate courses at Uzhhorod National University, Ukraine opens on 1st July and runs till 30th August. However, it is important that you apply before 30th July every year as the visa process can take anywhere from 2-3 months. Visa is issued only after you receive the invitation letter, and there have been cases where students were rejected a visa by Ukraine consulate.
Eligibility for MBBS Admission in Uzhhorod National University
Indian students who wish to study MBBS in Uzhhorod National University, Ukraine needs to fulfil the following eligibility criteria to quickly get admission.
The applicant should be over 17 and below 25 years old on or before the date of admission.
The applicant should be a high-school graduate or should hold an equivalent degree with Physics, Chemistry, Biology, and English as subjects.
The applicant should have secured at least 50% aggregate in all the above-mentioned subjects in 10+2.
If the applicant falls under the category SC/ST/OBC, he/she must have secured at least 45% in all the above-mentioned subjects in 10+2.
The applicant should clear NEET as it is mandatory for students coming from India.
Documents for MBBS Admission in Uzhhorod National University
Filled application form
Passport-size photographs
An original, valid passport
10th board exam scorecard
Attested character certificate
Filled NMC application form
MBBS Admission Procedure in Uzhhorod National University
All the candidates who meet the above-mentioned eligibility criteria can easily procure a seat at Uzhhorod National University, Ukraine.
Briefly listed below is the admission security to apply to Uzhhorod National University, Ukraine.
Fill the application form, and gather all the required documents.
The documents will then be sent to the university, where it will be analysed by the authorities, after which you will receive the invitation letter.
Once you receive the invitation letter, the process to apply for the Ukrainian visa begins at the embassy of the respective country.
Documents are submitted at the embassy and the admission fee is deposited to the Uzhhorod National University, Ukraine's
We assist you throughout the entire process of applying to the university till completing your 6-year MBBS course at the university in numerous ways. We carefully collect, analyse and send your documents to the university on your behalf, and initiate the visa process after receiving the invitation letter. With us, you will always get to enjoy a taste of the trust factor.
MBBS Fees in Uzhhorod National University
PARTICULARS TUITION FEE HOSTEL FEE
MBBS Fee (1st Year Package) 7000 $ Included in Package
MBBS Fee (2nd to 6th Year) 3800 * 5 = 19,000 $ 1000 * 5 = 5000 $
Total Fees in Rupees (INR) Approx. 18,20,000 Rupees 3,50,000 Rupees
Disclaimer: Study Europe Consultants cautiously affirm that the given amount of Tuition Fees is not volatile and subject to change without any prior intimation to the students. Also, the amount is in USD, not in Indian Rupees. To know the exact tuition fees, Hostel Fees, Living Cost and Exchange Value of USD in Indian Rupees, please contact our experts at Study Europe.
Accommodation Facilities in Uzhhorod National University
Uzhhorod National University, Ukraine offers 5 hostels with well-furnished rooms for students to reside in. The hostel spreads across an area of 28431 sq. and can accommodate around 2500 students. Every room is equipped with internet facility, beds, blankets, cupboards, water heating systems, and suitable lighting. Every section of the hostels also features a common kitchen and washroom.
Furthermore, the campus is also peppered with facilities such as cafeterias, clinics, student shops, playgrounds, and more. Students are allotted specific accommodation by the authorities after arriving at Uzhhorod National University, Ukraine and getting the health check-up done.
Uzhhorod is a city located 800 km west of Kyiv at the foot of Carpathian Mountains and highlights a population of 113,000 people. The region features a temperate continental climate and is protected from cold winds by the very Carpathian Mountains. The temperature ranges between -1.7-degrees Celsius in January to 20.9-degrees Celsius in July. The main attraction here is the Old castle located south-east in Uzhhorod. You can easily travel around the city leveraging public transport systems like minibuses and taxis. The architectural heritage and monuments are the best charm here. And, the botanical gardens and hydrological monuments add to the beauty of the place.
Why Choose Ukraine for MBBS Study?
Ukraine has witnessed remarkable growth and development in the education sector particularly in the medical education sector in the last one decade. Although, there are many good reasons for choosing Ukraine for MBBS Studies, we have brought to you the highly considerable reasons.
The Top Reasons to Choose Ukraine for MBBS Studies
World-class facility for study in medicine
No entrance test for admission in any medical university
Modern infrastructure with all the amenities
No capitation or donation fee
Affordable structure of fee for MBBS course
Strength of the class is maintained for better attention to all
Hassle-free and easy admission process for MBBS admission
The medical study in Ukraine is famous across the world for the best of the education that is being provided at the NMC approved medical institutions
Recognized by the leading bodies in the field of medicine including NMC, WHO various other medicine councils
Affordable cost of living and food
Numerous opportunities are opened with the completion of the course
The pleasant weather is one of the reasons why students love medical studies in Ukraine
MBBS Fees Structure and Course Duration in Europe
Why Choose Study Europe.in?
Is this your dream to study MBBS in foreign university? Then you may be asked to take the guidance from Study Europe agency. However, you may think that why others are speaking about this university? Why not the other agencies while there are numerous options for you? You will get all your answers from below
Study Europe is the best solution when you are looking for consultancy firm for MBBS abroad. You can complete rely and trust us
Our aim is to fulfill every MBBS aspirant's dreams
We take care of the overall admission procedure from start to the end
We provided categorized and customized solution to all MBBS aspirant
We deal with the best universities in Europe and all of them are accredited
We are available 24×7, you can contact with via our chat service
We are an authorized educational representative and fully trustworthy consultancy firm
Contact Us for guaranteed admission in the English Medium MCI approved Medical Colleges at affordable cost and study MBBS Georgia | MBBS Russia | MBBS Ukraine and MBBS Kyrgyzstan.
MBBS From Romania
Top Universities in Ukraine
Kharkiv Medical University
V.N. Karazin National University
Bogomolets Medical University
Dnipropetrovsk Medical Academy
Vinnitsa Medical University
Taras National University
Download University Brochure
Uzhhorod National University Brochure
Last Update: 19-Mar-2021
REVIEWS AND STUDENTS TESTIMONIALS
Aditya Prakash
Taras Shevchenko National University
Looking for satisfactory, transparent dealing, continued support, pre and post-admission support! Choose none other than Study Europe – the best MBBS abroad consultant in Delhi.
Swati Goraha
Why I choose Study Europe – the best consultant in Delhi is the transparency, professionalism, and the continued support in seeking admission to a NMC-approved college offering MBBS in Ukraine.
Anu Arora
It gives me a great pleasure in writing about my experience of preparing MBBS for Ukraine. Study Europe made me live my dream of MBBS study abroad with all the support.
Surendra Sharma
What I liked the most About Study Europe was the professional counseling and the assistance at every stage. The admission process of MBBS in Ukraine based university was made hassle-free for me.
Garima Singhal
I am Garima Singhal from Haryana. I am in second year of MBBS program enjoying my MBBS studies in Ukraine. All the credit goes to the expert team at Study Europe Consultants.
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Adults lose weight differently than kids and not as quickly. But the total immersion into a healthy lifestyle works for all ages. Camp Jump Start is the break in the rat race and allows you time to put into place an action plan that works. Group living will help you develop a strong support system that will last long past camp. Seeing yourself through the eyes of others will help change your own perspective and motivate you to make life saving changes in your life. You are worth taking the time to learn and set goals during one or two weeks in the spring and then see what a difference a summer can make as you live the realistic plan.
A health professional letter stating they will provide follow-up care.


text:
Pliny natural history book 8 translation parallel
The natural history was one of the first ancient european texts to be printed, in venice in 1469. The loeb classical library edition of pliny the younger is in two volumes. The table below is a summary based on modern names for topics. Pliny the elders natural history is a vast encyclopaedia, surveying natural phenomena from cosmology to biology, medicine to magic. Links to translation of pliny the elder, natural history, by h. Plinys natural history project gutenberg selfpublishing. It is no disparagement to hollands merits, as a diligent and generally faithful translator, to say that his work is unsuited to the requirements of the. Gaius plinius secundus 23 ad august 25, 79 ad, better known as pliny the elder, was a roman author, naturalist, and natural philosopher, as well as naval and army commander of the early roman empire, and personal friend of the emperor vespasian. The natural history of pliny, volume 6 bohns classical library the natural history of pliny, henry thomas riley. Mingling acute observation with often wild speculation, it offers a fascinating view of the world as it was understood in the first century ad, whether describing the danger of diving for sponges, the first waterclock, or the use of asses milk to remove wrinkles. Publication date 1938 topics natural history publisher. Naturalis historia is a book about the whole of the natural world in latin by pliny the elder, a roman author and naval commander who died in 79 ad.
As one of the largest and most comprehensive surviving works from the roman empire, pliny the elders natural history offers a rare glimpse into the scholarship of the ancient world. Even on that poiiit he contradicts himself in the next book. Since much of plinys geography is catalogued listings of places, translation is. Pliny has a gift for description and a versatile prose style, and more than any of his contemporaries he gives an unprejudiced picture of rome as he knew it. They are set out in the original text order of pliny the elder, and are then sequentially analysed. Search the history of over 439 billion web pages on the internet. Natural history pliny project gutenberg selfpublishing. Click on the l symbols to go the latin text of each letter. We would like to show you a description here but the site wont allow us. Editing a single book of the natural history as a single volume has the notable.
Natural history, volume x, books 3637 loeb classical library no. For the original article on pliny see dsb, see vol. Direct observation, informed speculation and common knowledge are combined to present a key snapshot of ancient thought and the romans perspective on the world around them. Latin and english parallel text throughout, with introductions, notes and indices. Naturalis historia is an early encyclopedia published circa ad 7779 by pliny the elder. The homepage for plinys natural history the historia naturalis of c.
Theophrastuss enquiry into plants or historia plantarum greek. But it has often been read with some mistaken presuppositions. Firth 1900 a few words and phrases have been modified. The first and thirtythird books of pliny were translated by dr. See key to translations for an explanation of the format. Links to translation of pliny the elder, natural history. Naturalis historia is an encyclopedia published circa ad 7779 by pliny the elder. Internet archive bookreader plinys natural history. Everyday low prices and free delivery on eligible orders.
Natural history, volume ii, books 37 loeb classical library no. With an english translation on opposite pages, notes, introduction, and glossary, by rev. Pliny the elder 2379 ce produced in his natural history a vast compendium of roman knowledge. This book is available with additional data at biodiversity heritage library.
Nov 17, 2019 a translation of plinys natural history. American museum of natural history handbook series no. Bostock, who contemplated a translation of the entire work. Natural history 1938 by pliny the elder, translated by h. A division of the earth by climates, lines parallel, and equal shadows. Fox, ma to which is added the anglosaxon version of the metres of boethius, with a free translation by martin f.
Plinys historia naturalis natural history is a vast encyclopaedic work and the only book by him to have survived. Unusually, the entire remarkable work it contains over a million words has survived intact it is one of the most substantial ancient works available to modern readers. The project gutenberg ebook of the natural history of pliny. The project gutenberg ebook of the natural history of. The natural history has been translated into english by h. The world, and this whatever other name men have chosen to designate the sky whose vaulted roof encircles the universe is fitly believed to be a deity, eternal, immeasurable, a being that never began to exist and never will perish. This barcode number lets you verify that youre getting exactly the right version or edition of a book. Philemon hollands english translation of 1605 has influenced literature ever since. Pliny the elder, natural history loeb classical library. Let us pass to the rest of the animals, and first those that live on land. Pliny s natural history is an astonishingly ambitious work that ranges from astronomy to art and from geography to zoology. The account of the essenes which pliny included in his compendious work natural history 5.
It is no disparagement to hollands merits, as a diligent and generally faithful translator, to say that his work is unsuited to the requirements of the nineteenth century. In 37 books, pliny the eldernot to be confused with his nephew, pliny the youngercovers botany, zoology, astronomy, geology, geography, mineralogy, and how each of these interact with roman life. The natural history book vii with book viii 4 latin texts by bloomsbury isbn. Download for offline reading, highlight, bookmark or take notes while you read the natural history of pliny. Plinys natural history is an extraordinarily important document in the history of western science. Synopsis each of the 37 38 books comprising the natural history 1 have been studied and the more important geographical facts extracted. Topics included are the mathematics and metrology of the universe. Cambridge, mass wikipedia citation please see wikipedias template documentation for further citation fields that may be required. Pliny the elder, who died during the eruption of vesuvius in 79 a.
Book vii of the natural history provides a detailed examination of the human animal and is. The only translation of plinys natural history which has hitherto appeared in the english language is that by philemon holland, published in the latter part of the reign of elizabeth. Natural history pliny wikimili, the free encyclopedia. It is one of the largest single works to have survived from the roman empire to the modern day and purports to cover all ancient knowledge. Plinys natural history is an astonishingly ambitious work that ranges from astronomy to art and from geography to zoology.
It is one of the largest single works to have survived from the roman empire to the modern day and purports to cover the entire field of ancient knowledge, based on the best authorities available to pliny. Pliny himself defines his scope as the natural world, or life. At any rate, the latin text and the holland translation have each been. The works subject area is thus not limited to what is today understood by natural history.
Natural history pliny wikimili, the free encyclopedia wikimili, the free encyclopedia. Tupper, dcl brands popular antiquities of england, scotland, and ireland. Zehnacker marshals to good effect parallel texts from pomponius mela. The only translation of plinys natural history which has hitherto appeared in the. The project gutenberg ebook of the natural history of pliny, vol i. In ad 77, pliny published his famous 37volume work naturalis historia or natural history.
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The founder and President, Gail Price-Wise, received her Master's degree from Harvard School of Public Health in 1986 and has spent much of her career improving communication among people of different racial, ethnic, and socioeconomic backgrounds. She has focused on the serious impact of miscommunication and mistrust on the provider-patient relationship and how this contributes to health disparities. She had developed on-line and in-person training curricula in cultural competence, language access, and health literacy for the US Department of Health and Human Services, the US Agency for International Development, and the Florida Department of Health. She led the development of the web site, "The Provider's Guide to Quality and Culture," (erc.msh.org/qualityandculture) which was recommended by the Institute of Medicine in its report on Unequal Treatment: Confronting Racial and Ethnic Disparities in Health Care. Ms. Price-Wise is a past President of the Harvard School of Public Health (HSPH) Alumni Council and chaired its international committee. She is a past President of the Harvard Club of Broward County. She has written about international policies affecting women's health for the recent edition of the women's health book, Our Bodies, Ourselves. Her article "Language, Culture, and Medical Tragedy" was published in the Health Affairs blog, November 19th, 2008 (www.healthaffairs.org/blog). Ms. Price-Wise speaks Spanish and has worked or traveled in 24 countries.
Erik Camayd Freixas, Ph.D. is Director of the Translation & Interpretation Program at Florida International University. He served as Director of the ISP Interpreter Training Program for the Florida Department of Children and Families and the Florida Department of Health. In that capacity, he developed the interpreter training curriculum that is used throughout the state and personally trained and tested almost 3000 interpreters. As a federally certified interpreter, Dr. Camayd interprets in federal court and on Spanish-language television for US Presidents and other high profile officials. He has written several books, including Interpreter Training: Legal, Medical, and Business Settings –An Introductory Textbook and Berlitz Consecutive Interpretation Exam and Evaluator Training Manual. Dr. Camayd received his Ph.D. from Harvard University in 1995 in Romance Languages and Literature. Dr. Camayd was born in Cuba.


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text:
package ark.model.annotator.nlp;

import ark.data.annotation.nlp.DocumentNLP;
import ark.model.annotator.Annotator;

public interface AnnotatorToken<T> extends Annotator<T> {
	T[][] annotate(DocumentNLP document);
}


I'm almost done with Backs Against the Wall, the second installment in the Survival Series! I'm hoping to have it out in early March.
The room is small but warm with two beds, one small desk and a window that has been all but boarded shut. The beds are nothing but old, bare mattresses with blankets tossed over them. I notice that the floor is covered in clothes. I glance at Trent in surprise, shocked to see that Mr. Methodical is a pig at heart, but whatever insult or question I had for him dies on my lips. The wall beside one of the beds has been hollowed out, the drywall stripped down, the insulation yanked out. In its place is shelf after shelf secured between the wood. On those shelves are more books than I can ever remember seeing in one place. I'm sure I went to the library at some point as a child, but I honestly can't remember and right now, I truly do not care. Even if those libraries of the old days had housed a million books, they couldn't compare to this. To one wall full of treasures saved and preserved in a world where everything and everyone wastes away to ash and dust.
"Little bit," I mutter in agreement.
I feel myself blush at the idea of laying in his bed. Honestly, I think I'd be more comfortable laying in Trent's. There's something less…I don't know. Meaningful about it, I guess. Sleeping in Ryan's bed, well, I almost feel like I'd enjoy it too much.
"I don't want to bleed on his bed," I say lamely, gesturing to my jacked up arm.
I'm too tired to stand. I'm too beat down, exhausted, aching tired to be proud or embarrassed either. I carefully step through the room, mindful of the piles of clothes on the floor, trying to avoid them, but failing. Then I carelessly collapse on his bed. The sigh that escapes my lips is pure joy leaking from my soul. I slept on a bed in the Colony. It was weird and awesome at the same time, but I also resented it. It was always a sign of the world being forced on me, of the lie they were all living. But this is different. This mattress is far less comfortable, far more worn and it smells of dude. It has the faint scent of a very familiar soap made by the wizard of the woods and the earthy smell of good old fashioned stink. It's earth and sweat. Grass and warm skin.
This I kind of love.
Can't wait to have this gem in paperback next to the first one!


Sweet Erik and Jake...Spoiled from the get go!! Jake was held from day 2 until he was about 10 mos old LOL.
Well here we go. The fun starts now LOL. Things are actually going great here in Georgia. I just really wish that we knew where we were going next. It is driving me crazy not knowing what the Army is about to throw our way. I mean come on now can't you plan things more then 2 weeks in advance???? November will be here before we know it and Josh will no longer be a drill sgt. Now don't get me wrong...I don't like this job...... but I have seen more of my darling husband in the last 2 years then I have the first 6 years of our time together!!!!! Not to mention that extra $$ is nice :) I can sit here and say "Yep I am ok with deployments and seperations" and for the most part I am. But Dang I have grown attached to Josh LOL. Anyways, so we are waiting for what our lives are going to be like next. I am thinking it is going to be the kids and I here while he heads off to play in a sandbox like his 2 yr old LOL. I guess Michelle and I will have to drive and visit b/c we will both be in the same boat for a few months LOL. Life now is full of baseball and softball and more baseball and softball LOL. We are keeping very very busy between JT and Savannah and it is making time fly. I can't even imagine what it will be like when Jake starts AAAHHH...Like Leslie said, I will need a rent-a-mommy."
Wow!!! Little did I know that a couple tryouts and an extension would be put in place LOL. Amazing how much can change in a year! Yep I have been blogging for a year...absolutely amazing hahahaha. We are back to baseball and softball and well I NEED A RENT-A-MOMMY!!!!!! LOL...and here we are facing that deployment. Hmmm...am I still ok with it ? I can now honestly say "BRING IT ON!" I am now ready for it and no it is on its way...no more waiting for those silly Army orders..just the silly Army date!
Josh has finally left. In a way it is nice to have our schedule started, but I know that as the next couple of weeks go on it will get a lot harder before it gets easier. Having him 16 hours away is frustrating because it is too far for a weekend trip, but close enough to drive me crazy that he is still in the States LOL. The kids did really well. We kept them home from school because we didn't know how Savannah would do. Yesterday she broke down in the middle of a bite of French Toast at Breakfast... so who knew what she would do today. Turns out she was ok. JT well he just says he is really bummed but will be ok. Jake...now that is the one that is going to be tough. He had a rough day with attitude because he knew something was going on. He says he lost Dad and he can't find him-even though he has talked to him on the phone LOL. Crazy how little kids minds work. I heard him asking JT if he would be home tomorrow and listened to JT explain to him it would be a long long time...oh the words of JT..so comforting...I am a very lucky Mom to have a child with the wisdom and words that he does. Josh will be arriving to Riley soon...I am waiting for the call...still a couple more hours to go LOL. Our next chapter has officially begun and I can't wait to see what adventures it is going to hold. I know it will have lots of trips to visit Margaux. I can't wait to see what adventures our kids will get into!!! I am so blessed to have her as one of my best friends. I only hope that I can repay her the favor of putting up w/ my crazies and our visits!!! Oh yes and we have a trip home in the works!!! WOOHOOO TIME FOR THE LAKE!!! Forget family...we don't go home to see family..we go home to ski, board, and boat for days on end LOL.
How dare my hands get dirty!!!
LOOK THE EASTER BUNNY LEFT PROOF!!!!
My sweet baby is growing up too fast!!!
A couple of weeks ago we headed to Atlanta for a family trip. We had a wonderful time hanging out and spending time together. The kids had a blast...except for the fact that they think we tried to starve them while we were there :) We refused to feed them at the food court and they were most definitely starving by the time we left!!!!
Touch Pools!!! He had to almost go swimming himself to reach LOL.
Watching fish....we could have sat there all day!!!


BLUF: Carry one weapon at work and a different one for personal time? Pistol taco's have you covered.
No matter what pistol you scavenge from the fallen, theses pouches will hold those magazines.
It can also hold a variety of Multi-tools and Flashlights securely.. Made of Cordura, Kydex and shock-cord, it is silent when stuck against and while extracting the mag. The "Pistol TACO" maintains a positive grip on the mag on which is adjustable and does not need any other use of a securing system. Made in the USA and is covered by the HSGI Lifetime warranty. Malice clip included.