Many things can inspire faith in religious and religious beliefs and faith tattoos are few of them. Like hope, tattoos of religion could pass on to at least one's mindset of lifestyles, philosophy, set of pointers, no longer vital to bypass on spiritual beliefs.
Religion is a conviction in a person philosophy of dwelling life or something which will be non secular ideals like buddhism, hinduism, jewish, christianity, islam, etc. Or trust within the connection of own family or self-perception of affection.
Religion is something that's very private, but no need to hold it undisclosed. Faith is not decided via the sight, instead of it's far decided by your accept as true with and belief. It's far an influential emotion and is the shifting pressure in our very own global.
Notion in you is equal to notion in almighty god. That's the philosophy of existence, on which books can be written. However without elaborating some thing and transferring ahead when we communicate approximately religion tattoo designs, then a spiritual image like cross, ohm, david superstar, part of bible quote or the photo of jesus christ or the buddha could be tattooed to articulate the faith of humans inside the shape of tattoos.
Faiths tattoos are generally visible tattooed on top and obvious part of the body, i.E, the arm, back, neck and wrist various consistent with the sizes. However that's not a strict rule many articulate their faiths through inking their legs and foot also. Maximum tattoos that human beings ink to articulate their faiths to have the actual word "religion" in it. The differentiation inside the designs can also come due to the real font used to ink the phrase. Different factors inclusive of bird, infinity sign, flower and butterfly the ones are noteworthy to the faiths, and on the identical time they may be no longer strictly connected with any unique faith are blanketed to make religion tattoos more unique and more non-public.


The most successful posts are useful. They help someone do something new, see something differently, or make a decision. I know I've done something right when a LinkedIn follower tells me they have used a story of mine to illustrate or enhance their own presentation.
Articles and ideas that excite people and raise questions are a mark of quality output. I take note of the feedback I get from readers. I read comments and analyse the responses. I find out what gets people enthused, and what has pushback.
Sometimes I'll republish old posts if there's good reason. It may be that something in the news has made it particularly relevant, or it may be that I think I got something wrong, I'm never afraid to revisit my ideas and admit when I've changed my point of view if I have become educated by feedback or new and better information.
Most importantly, write what you know. Write something only you can write, because you have a deeper understanding than most, or a new perspective on a subject.
We consistently see that the posts that do well on LinkedIn are strongly aligned to that person's area of expertise, interest, and passion. They are authored to provide insights and share personal learnings to LinkedIn members around the globe.
What NOT to write is almost as important as what to write. Don't spout opinions that aren't supported by facts. If you can't back up your position, you'll be found out quickly, and the internet loves letting someone know they're wrong.
For example, following my post What Board Directors Need to Know About the Blockchain a close friend of mine called me to say that quote from Marc Andreessen is an urban myth he never said it!
I was able to search Evernote and send him the link to Professor Russell Roberts' interview with Marc pointing out the exact quote at 34 minutes and 20 seconds into the interview. You can hear Marc saying that blockchain technology is the most significant development in the internet since the internet itself.
Don't write about something that is boring or obvious. Nobody wants to read a rehash of the same thing they saw last week and the week before that. Bring something new to the debate.
Negativity rarely works. Vindictiveness, or vengeful sprays about people or companies are seldom received well on LinkedIn and will inevitably come back to bite you.
That's not to say you should never post anything controversial. Disagreement can be valuable. A provocative post that gets people talking and commenting is a successful post.
Disagreement can be valuable. A provocative post that gets people talking and commenting is a successful post.
My wife, a professional writer, taught me to keep notes of everything. She keeps a journal, but I use Evernote and Mindmeister. I'm constantly gathering content for future posts, articles or interviews. I have Evernote installed on all my devices and every time I hear a snippet of wisdom, or read an article of interest, into Evernote it goes. I then use Mindmeister to connect those ideas together as the foundation for a post.
I start with a premise and one key thing I want someone to take away from my piece. I build an article around that take-away. I take several sessions to get to final draft as I go back, reflect and edit.
I've taken these on board in my LinkedIn posts. Sometimes it's easy to use technical terms or trade lingo. 'A rookie mistake is to use language that is far more complex than what you use in conversation,' says Pell. 'This can be distancing for your reader'.
It can be tempting to write academically, with long paragraphs that cover everything you know about a subject. That's a sure-fire way to put your reader to sleep. The trick is to write in short paragraphs that are easy to follow.
Subheadings make an article scannable and easy to understand. They are especially important on web copy, where people are used to scrolling through quickly.
Never underestimate the power of a good headline. The headline is the first thing – often the only thing – people will see in their newsfeed.
I like to start with a slightly controversial but honest headline. These can often take a lot of trial and error to get right. Pell says sometimes headlines can take as long to write as the article itself. 'The headline has one job to do and that is to get someone to read the first line of the article. If it doesn't do that job, it has failed,' he says.
The headline has one job to do and that is to get someone to read the first line of the article. If it doesn't do that job, it has failed.
I have a caveat: the headline has to be supported by the story. There has been a marked backlash lately against clickbait headlines that lead to an underwhelming article. If you have a great headline, back it up by delivering a great post.
For more tips on writing great headlines, see the video discussion from 6:58 – 10:35.
When I left IBM to start my very first business in 1985, the only way to get real exposure was through PR companies. It was expensive and difficult to get major coverage to the right audience.
With a platform like LinkedIn, you can access an audience of millions of readers. However your audience is unlikely to run to thousands (or millions) unless it's supported by a well thought out distribution plan.
As soon as your connections begin engaging with your content, LinkedIn has a natural amplification effect. Whether your connections are liking, sharing or commenting on your content, those actions are pushed into the newsfeed. The more engagement you can generate from your connections and followers, the larger your potential audience becomes.
With this as context, you should build a distribution plan that emphasises building engagement from your connections quickly after launch. Personally, I've found it effective to notify my connections via email. I also know of people who've successfully used Twitter and other social channels to help build initial momentum on LinkedIn.
When thinking about distribution, it's also worth contacting the PR and social teams of any organisations you represent (in either an executive or non-executive capacity). These teams are usually only too happy to help promote your content through corporate channels.
These different metrics tell you different things about the success of a post.
The number of views on an article or video tells you how successful your headline and topic choice has been. Once you have several posts looking at views provides a snapshot of which subjects are most popular. You can begin to analyse why certain posts do better: Is it an attention-grabbing headline? Is it aligned to a specific area of your expertise? Is it particularly practical or novel?
More important than the number of eyes on an article is the level of engagement it inspires. Likes, shares and comments all track engagement, at progressively deeper levels. One helpful tip I've learnt when tracking engagement is it's much more important to focus on the percentage figure of readers engaging with your content than the overall number. Achieving twenty comments could be either good or bad depending on how many people read the article – it's much more meaningful to know that 10% of readers commented.
Ultimately insightful, thoughtful contributions to the conversation by others in the field are the best mark of a successful post. When there has been a substantial stream of comments on a Post I scrape the comments into Mindmeister grouping them into topics. Then after 10 days or so, I edit carefully whilst acknowledging each valuable contribution and repost as I did for 'Your Comments 10 Powerful Technology Questions for the Boardroom'. The audience can then use this curated content to advance their board's thinking on the subject without having to trawl through 100 comments.
Insightful, thoughtful contributions to the conversation by others in the field are the best mark of a successful post.
Steve Pell describes measurement in terms of "top of the funnel metrics" and "bottom of the funnel metrics". Top of the funnel are those things I've described above: the number of views, likes and shares, and the number of valuable comments.
Steve's "bottom of the funnel" measures whether this has this translated into opportunities. It looks at whether you have seen an increase in invitations to sit on new boards as a non-executive director, speaking opportunities at prestigious conferences, interviews for magazines, or TV appearances.
I've had several approaches since harnessing the possibilities of LinkedIn. I've taken up one new non-executive directorship and spoken in a number of forums.
In addition, I've had a number of directors inform me that they've included my articles (and the comments) in board reading packs. Given my aim of improving board-level conversations on technology governance, that's perhaps the strongest indicator that my thought leadership has been successful.
To answer these questions, in this article I'm going to provide a deep look into why I'm producing thought leadership content on LinkedIn. I'm also going to follow this up with a second article on my specific process – or how non-executive directors can build thought leadership on LinkedIn.
Thought leadership means positioning yourself as the go-to person on a particular subject. It's about leveraging expertise into opportunities.
Steve Pell says, 'If you're a thought leader, you should be the person who your audience thinks of as the first person they want to help solve their problems,' he says. 'Thought leadership means achieving front of mind positioning in whatever space it is that you're an expert'.
Having the expertise is one thing; thought leaders also must broadcast that expertise to a wide, relevant audience. Traditionally, this meant getting published and quoted, speaking at conferences, or being interviewed for TV or print media. Nowadays we have the technology to do it ourselves, do it quickly, and do it our way – through platforms like LinkedIn.
Why should directors build thought leadership on LinkedIn?
If someone was to invite you to speak on stage at the AICD Directors Conference, would you say yes? Just like speaking at a large conference, publishing regular thought leadership content on LinkedIn puts your ideas in front of an audience of thousands on a regular basis.
For me, the decision to publish frequently on LinkedIn is a no-brainer. I get to talk about the things I'm passionate about with an audience of thousands of interested people. It's a win-win for everyone.
LinkedIn provides instant feedback and analytics tools that allow you to gauge engagement. I know where my readership comes from and if it is rising or dropping. I know if an old post has had a sudden resurgence. I can tell if people are watching all the way through a video or dropping out in the first minute.
I see comments as the ultimate validation that the content I'm producing is resonating. It's great that some of my articles have spurred over 100 people to comment, but more importantly, those comments are intelligent, thoughtful reflections on my content. That level of engagement is comparable to an article in mainstream media.
For more discussion on why directors should build thought leadership, see the video from 0:04 – 06:15.
The greatest strength of LinkedIn is the quality of the 'crowd'. When I post on LinkedIn, I'm sharing my ideas.
The magic happens in the comments section below my post. The engagement and input from my audience leads to idea creation and exciting new opportunities that can never come from one person alone.
I often find myself quoting James Surowiecki's 2004 book The Wisdom of Crowds. Surowiecki says 'under the right circumstances, groups are remarkably intelligent, and are often smarter than the smartest people in them'. He supports this proposition with empirical evidence. Overall, where groups of people share independent information, they consistently make better decisions than any one person in the group could.
Illustrating just how valuable these comments can be, I've had a number of directors tell me that they've included the comments summary from my article on "Technology questions for the board" into their monthly board reading pack.
For more discussion on the benefits of LinkedIn, see the video from 08:15 – 10:21.
Whilst I agree with Steve that you need to have followers to be a thought leader, I stress that you also need to be a follower. There is no single person with all the knowledge.
When engaging with followers on social media, if you're clued-in, you'll recognise when others want to take on leadership roles. Be humble enough to encourage and embrace "co-leaders" who have something else to add. Doing so will make you a better leader.
I could have written this article alone. But I'm happy to call upon the expertise of Steve and Clifford. Their perspectives make my article better, but it's a two-way street. By calling on their expertise and quoting them here, it reinforces their reputations as thought leaders in their respective fields.
LinkedIn has over 500 influencers who publish long-form content on LinkedIn. As leaders in their industries, geographies, and seniority, they discuss topics of interest, such as leadership, management, entrepreneurship, disruption, and how to succeed. This is a handpicked community of thought leaders that you could follow.
Are you a leader or a follower? If you want to be a true thought leader, you have to be both.
Thought leaders don't simply look for what they can get out of sharing a post or a video or article, they constantly question how they can add value for their audience. Being an expert means having a purpose and a passion, which you want to share with others. The biggest mistake you can make is thinking it is all about you. It's a reciprocal deal.
The "leadership" in "thought leadership" means leading a discussion that is important for the community, but it has to be two-way. Your output should be useful to your audience and help them achieve their goals.
My goal is to increase the capability of directors to make use of emerging and novel technology and to participate in good governance of decisions in the hundreds of million-dollar range. I need to get others excited and engaged and come with me on that journey. So when I make a post about the blockchain or augmented reality, I'm not just showing off how much I know; I'm constantly thinking about how it might help others or provoke a useful debate that can help boards make better technology decisions.
You soon learn to spot patterns, and now within a few hours of posting I know whether my latest post has resonated, incited or fallen flat. I use the feedback (or lack thereof) to change the way I assemble things, re-prioritise and continually improve.
Engaging with the people who have taken the time to comment, and prompting further discussion and debate in the comments, is vital. If I don't have the data or skill to argue a particular point, I may call upon my network. If I know someone who has specific knowledge about something raised in a comment to my post, or if I think they may have a different view I might approach him or her and ask them to respond, sparking further debate. People appreciate being asked to participate and that I recognise them as an authority and value their opinion.
What should your area of expertise be?
Think you don't have the requisite expertise to be a thought leader? If you're knowledgeable enough to be a senior executive or sit on a board, you're almost certainly an industry-leading expert in some space. The trick is to define a narrow scope for your thought leadership.
For example it's hard to become the sole go-to source for M&A. You need to narrow it down. M&A opportunities in Asia is still a big pool. But if you know a lot about M&A opportunities coming out of Singapore for sub-$100m cap companies, there is definitely room to position yourself. Even though there may be one or two people who know more than you, if you've put yourself out there, you will generally be considered the authority. The narrower you can make the scope for expertise, the easier to position yourself as a thought leader in that area.
I'll talk about this more about positioning and specific topics in my second article in this series.
So what value does being a thought leader bring to organisations I advise and work with?
Being a thought leader and sharing via LinkedIn widens my network and sphere of influence. When the board needs expert input, I'm more likely to have a connection I can introduce to the discussion. In the same way, when other organisations need expert input on technology governance, I'll often get a call and be able to make introductions to organisations that I work with.
As Clifford Rosenberg says, 'people are just starting to realise how much value there is in their broader network. What you can see on LinkedIn is the range and diversity of people who know someone you know.
Also, because people trust my expertise in the technology governance space, by extension there is enhanced trust and credibility in the organisations I represent.
Becoming a thought leader isn't something that just happens. It requires expertise, but more importantly, passion in your subject matter. It means admitting to, and learning from, failure as well as success. It takes effort and insight into your own behaviour.
LinkedIn makes it easier than ever before, but it still requires an ongoing commitment and a willingness to work at building your profile, engaging with your audience and striving to improve. Most of all you have to be prepared to commit for the medium to long term. If you need quick results, in a week or two, this isn't the right strategy for you.
For more discussion on how thought leadership delivers value to organisations, see the video from 10:20 – 11:50.
The fastest way to create a successful CEO blog is to draw inspiration from some of the best existing examples. We've found that instead of trying to reinvent the wheel, one of the best ways to get started as a CEO blogger is to adapt the strategies that have worked for others.
We have analysed the most successful executive blogs and identified the attributes that can be easily adopted and adapted. Obviously, not all of these tactics will be applicable to every situation, but they can provide a template for a traffic-generating CEO blog.
The Microsoft founder does a great job of combining his personal interests and publicising causes that he believes in. Gates uses the blog to promote the work of his charity, the Bill and Melinda Gates Foundation, and to publicise causes he is passionate about, such as energy technology.
Bill Gates effectively uses some basic images to explain the purpose of his blog and his activities.
The two best things about Gates Notes are the manner in which Bill goes out of his way to provide useful information, and how he recognises the power of entertainment. Gates provides useful knowledge in the form of a reading list of books he's enjoyed and his thoughts on some titles. The reading list gives people a reason to regularly visit the site.
Gates offers some entertaining content, such as a piece on The Deadliest Animal in the World. The animal is actually a mosquito, which his foundation is trying to eradicate. This story provokes thought without lecturing or boring readers.
The most effective page at Gates' blog might be this one, which shows readers he is more than just the former CEO of Microsoft, he's a human being with a past.
Something else to observe is how Gates also effectively adapts some classic newspaper promotion strategies, such as using sensational headlines to make his blog more thought provoking.
Those that want to see how a blog can be used to effectively promote a cause and to combine entertainment and education need to take a look at Gates Notes.
Malley proves that it is possible for a busy CEO to write an effective blog. The chief executive of CPA Australia, one of the world's largest accounting organisations, and the host of The Conversation with Alex Malley on Nine Network Australia, is the driving force behind this blog targeted at students entering the employment market for the first time.
Like Gates, Malley understands the power of entertainment, but he also knows that blogs must provide useful information to attract repeat traffic.
Malley effectively achieves this goal and entertains his audience with slide shows on topics such as How to Deal with the Office Grump. The slides themselves provide an attention-grabbing visual effect for the blog.
Alex Malley effectively uses humor and stunning visuals to make his blog more entertaining.
One of the best features of the Naked CEO blog is the Ask Alex a Question page. Instead of merely commenting, visitors can ask Alex a question, and he will answer some of them on video. This feature helps Malley establish a rapport with his readers and builds up his reputation as an industry expert and a problem solver.
Another advantage to this feature is that it allows Alex to interact with readers without spending all his time responding to comments.
Red Balloon founding director Naomi Simson leverages her success on Channel Ten's Shark Tank with this colourful blog. We were impressed by the effective manner in which Simson uses it to promote her activities, including public speaking, writing books, and charitable causes. She communicates effectively by coming across as a real person, a mother, and an executive rather than just a talking head.
By using Pinterest posts like this, Simson establishes herself as an expert in her subject.
Simson actively leverages her blog by posting photographs of herself on Instagram and quotes from famous people on Pinterest. This low-cost strategy attracts followers with minimal effort.
Pinterest is one of the more powerful social media tools because it encourages others to share images you upload. The Pinterest posts drive traffic and build credibility by establishing Naomi Simson as a source of knowledge.
Flickr cofounder Caterina Fake proves that you can create an intelligent and thought-provoking CEO blog without fancy graphics or a lot of visual content. Her site is simple and clean, yet it conveys a lot of really good information.
What we liked best about Fake's blog is the simple white background that makes it very easy to read. There's nothing to distract the reader; instead, the focus is on the ideas that she is trying to convey. A really nice touch is the portrait that makes Caterina look like a real person. Fake proves that simple blogs can be just as effective as the complex ones.
5. Blog Maverick (The Mark Cuban Weblog) – Billionaire Mark Cuban is a popular and controversial figure in the United States.
Mark Cuban uses his blog to counter his popular image as an aggressive and thoughtless businessman.
Cuban makes Blog Maverick a go-to destination by simply sharing his opinions on issues in the news. He offers thoughts on legal and political matters and headlines. A fascinating example is this post on social media and American elections. By discussing such matters, Cuban reaches a much larger audience and relates his philosophy to the masses.
Another reason why this blog works so well is that Cuban effectively conveys his passions. It also shows a different image of Cuban, who comes across as somewhat abrasive on television. The posts show readers that Cuban is a highly intelligent and well-read man who is something of an intellectual. Blog Maverick demonstrates how a good weblog can be used to change a CEO's image.
One interesting aspect of Blog Maverick is the way in which Cuban uses an app called Cyber Dust as an alternative to a traditional comments section.
Marketing guru and brand ambassador Guy Kawasaki does not post that often, but when he does, it is worth reading. Nobody seems to do a better job of conveying a basic business philosophy—that of marketing as evangelism—than Kawasaki does.
Guy Kawasaki makes his blog a go to destination by limiting his number of posts.
Kawasaki's old blog, the Art of Evangelism, simply posted essays, yet they were highly effective. This post conveys a very complex concept, that of product evangelism, and provides a blueprint for utilising the method in day-to-day business.
We liked this mix of actionable information with complex concepts. Kawasaki succeeds in showing how to share experience and business philosophy as useful information. In his current blog, Guy Kawasaki does much the same; in this post on start-ups is another example of a useful lesson presented in an entertaining manner.
Kawasaki realizes that one of the most important roles of a blog is to share wisdom.
Reid Hoffman, the co-founder and executive chairman of LinkedIn, successfully demonstrates how to combine social media and a CEO blog. The blog simply redirects visitors to Hoffman's posts on LinkedIn.
We liked the way in which Hoffman's posts followed a theme: marketing. We were also impressed by Hoffman's writing style in which he succeeds in communicating complicated business concepts to a mass audience. One way in which Reid does this is by using familiar pop culture icons such as Star Wars characters as examples.
Hoffman leverages the power of LinkedIn by using his blog to promote his presence on social media.
Why is LinkedIn Called LinkedIn?
Another effective trick Hoffman uses is to leverage the power of images such as stills from movies to spice up his blog. By posting interesting images, Hoffman makes his site slicker and more professional looking at a low cost.
One of the biggest flaws that we see in CEO blogs is lack of focus. This simple blog created by Dharmesh Shah, the founder and chief technology officer of HubSpot, works because it maintains a laser-like focus on marketing for growing startups.
Visuals from slideshows and PowerPoint presentations are a cheap and low effort means of adding stunning visuals to your blog.
Shah covers a wide variety of topics, but they are all related to entrepreneurship. The blog works because his passion for marketing and genuine expertise on the subject shines through.
We also liked the large amount of information that Shah shares with his audience. He gives them a reason to come back because they actually learn something from his content.
These blogs demonstrate that one of the best ways to learn how to blog is to read and analyse the blogs of other CEOs. In a round-a-bout way, CEOs that want to become effective and popular bloggers must become devoted blog readers. Just remember to select your role models carefully; some CEOs blog in ineffective ways. But if you use this list as a springboard to launch from, you'll easily find dozens of other examples that will guide you on your way to a successful CEO blog.


Tasty Weekend at Agriturismo Giovanna Passeri!
This weekend your kids can't miss the Halloween Cooking Class! They'll have a lot of fun preparing delicious Halloween themed surprises such as Chocolate Bat Cookies, Halloween Cake Pops, Pumpkin Cupcake and Chocolate Witch Hats!
And there's no need to worry if you are not a child anymore or you don't feel like joining other cooking classes, since Giovanna Passeri has tought up some mouthwatering menus you'll definitely enjoy.
Here you can have a look at Agriturismo Giovanna Passeri's fine selection of food and you'll also find further interesting information.
This entry was posted in brianza, food, holiday, italy, wine and tagged brianza, cooking class, dining, Giovanna Passeri Agriturismo, holiday, ilpoggioverde, restaurant. Bookmark the permalink.


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We examine empirically how the maturity structure of government debt affects bond yields and excess returns. Our analysis is based on a theoretical model of preferred habitat in which clienteles with strong preferences for specific maturities trade with arbitrageurs. Consistent with the model, we find that (i) the supply of long- relative to short-term bonds is positively related to the term spread, (ii) supply predicts positively long-term bonds' excess returns even after controlling for the term spread and the Cochrane-Piazzesi factor, (iii) the e®ects of supply are stronger for longer maturities, and (iv) following periods when arbitrageurs have lost money, both supply and the term spread are stronger predictors of excess returns.
All material on this site has been provided by the respective publishers and authors. You can help correct errors and omissions. When requesting a correction, please mention this item's handle: RePEc:ehl:lserod:24425. See general information about how to correct material in RePEc.


Citation Information: J Clin Invest. 2017. https://doi.org/10.1172/JCI90086.
Microvascular endothelial cells (ECs) are increasingly recognized as organ-specific gatekeepers of their microenvironment. Microvascular ECs instruct neighboring cells in their organ-specific vascular niches through angiocrine factors, which include secreted growth factors (angiokines), extracellular matrix molecules, and transmembrane proteins. However, the molecular regulators that drive organ-specific microvascular transcriptional programs and thereby regulate angiodiversity are largely elusive. In contrast to other ECs, which form a continuous cell layer, liver sinusoidal ECs (LSECs) constitute discontinuous, permeable microvessels. Here, we have shown that the transcription factor GATA4 controls murine LSEC specification and function. LSEC-restricted deletion of Gata4 caused transformation of discontinuous liver sinusoids into continuous capillaries. Capillarization was characterized by ectopic basement membrane deposition, formation of a continuous EC layer, and increased expression of VE-cadherin. Correspondingly, ectopic expression of GATA4 in cultured continuous ECs mediated the downregulation of continuous EC-associated transcripts and upregulation of LSEC-associated genes. The switch from discontinuous LSECs to continuous ECs during embryogenesis caused liver hypoplasia, fibrosis, and impaired colonization by hematopoietic progenitor cells, resulting in anemia and embryonic lethality. Thus, GATA4 acts as master regulator of hepatic microvascular specification and acquisition of organ-specific vascular competence, which are indispensable for liver development. The data also establish an essential role of the hepatic microvasculature in embryonic hematopoiesis.
Citation Information: J Clin Invest. 2017. https://doi.org/10.1172/JCI87583.
Citation Information: J Clin Invest. 2017. https://doi.org/10.1172/JCI89444.
BACKGROUND. Dietary intake of saturated fat is a likely contributor to nonalcoholic fatty liver disease (NAFLD) and insulin resistance, but the mechanisms that initiate these abnormalities in humans remain unclear. We examined the effects of a single oral saturated fat load on insulin sensitivity, hepatic glucose metabolism, and lipid metabolism in humans. Similarly, initiating mechanisms were examined after an equivalent challenge in mice.
METHODS. Fourteen lean, healthy individuals randomly received either palm oil (PO) or vehicle (VCL). Hepatic metabolism was analyzed using in vivo 13C/31P/1H and ex vivo 2H magnetic resonance spectroscopy before and during hyperinsulinemic-euglycemic clamps with isotope dilution. Mice underwent identical clamp procedures and hepatic transcriptome analyses.
RESULTS. PO administration decreased whole-body, hepatic, and adipose tissue insulin sensitivity by 25%, 15%, and 34%, respectively. Hepatic triglyceride and ATP content rose by 35% and 16%, respectively. Hepatic gluconeogenesis increased by 70%, and net glycogenolysis declined by 20%. Mouse transcriptomics revealed that PO differentially regulates predicted upstream regulators and pathways, including LPS, members of the TLR and PPAR families, NF-κB, and TNF-related weak inducer of apoptosis (TWEAK).
CONCLUSION. Saturated fat ingestion rapidly increases hepatic lipid storage, energy metabolism, and insulin resistance. This is accompanied by regulation of hepatic gene expression and signaling that may contribute to development of NAFLD.
FUNDING. Germany: Ministry of Innovation, Science, and Research North Rhine–Westfalia, German Federal Ministry of Health, Federal Ministry of Education and Research, German Center for Diabetes Research, German Research Foundation, and German Diabetes Association. Portugal: Portuguese Foundation for Science and Technology, FEDER – European Regional Development Fund, Portuguese Foundation for Science and Technology, and Rede Nacional de Ressonância Magnética Nuclear.
Citation Information: J Clin Invest. 2017. https://doi.org/10.1172/JCI85499.
Hepatic steatosis is caused by metabolic imbalances that could be explained in part by an increase in de novo lipogenesis that results from increased sterol element binding protein 1 (SREBP-1) activity. The nuclear receptor liver receptor homolog 1 (LRH-1) is an important regulator of intermediary metabolism in the liver, but its role in regulating lipogenesis is not well understood. Here, we have assessed the contribution of LRH-1 SUMOylation to the development of nonalcoholic fatty liver disease (NAFLD). Mice expressing a SUMOylation-defective mutant of LRH-1 (LRH-1 K289R mice) developed NAFLD and early signs of nonalcoholic steatohepatitis (NASH) when challenged with a lipogenic, high-fat, high-sucrose diet. Moreover, we observed that the LRH-1 K289R mutation induced the expression of oxysterol binding protein-like 3 (OSBPL3), enhanced SREBP-1 processing, and promoted de novo lipogenesis. Mechanistically, we demonstrated that ectopic expression of OSBPL3 facilitates SREBP-1 processing in WT mice, while silencing hepatic Osbpl3 reverses the lipogenic phenotype of LRH-1 K289R mice. These findings suggest that compromised SUMOylation of LRH-1 promotes the development of NAFLD under lipogenic conditions through regulation of OSBPL3.
Citation Information: J Clin Invest. 2016. https://doi.org/10.1172/JCI88486.
Malignant tumors develop through multiple steps of initiation and progression, and tumor initiation is of singular importance in tumor prevention, diagnosis, and treatment. However, the molecular mechanism whereby a signaling network of interacting pathways restrains proliferation in normal cells and prevents tumor initiation is still poorly understood. Here, we have reported that the Hippo, Wnt/β-catenin, and Notch pathways form an interacting network to maintain liver size and suppress hepatocellular carcinoma (HCC). Ablation of the mammalian Hippo kinases Mst1 and Mst2 in liver led to rapid HCC formation and activated Yes-associated protein/tafazzin (YAP/TAZ), STAT3, Wnt/β-catenin, and Notch signaling. Previous work has shown that abnormal activation of these downstream pathways can lead to HCC. Rigorous genetic experiments revealed that Notch signaling forms a positive feedback loop with the Hippo signaling effector YAP/TAZ to promote severe hepatomegaly and rapid HCC initiation and progression. Surprisingly, we found that Wnt/β-catenin signaling activation suppressed HCC formation by inhibiting the positive feedback loop between YAP/TAZ and Notch signaling. Furthermore, we found that STAT3 in hepatocytes is dispensable for HCC formation when macrophage-stimulating 1 and 2 (Mst1 and Mst2) were removed. The molecular network we have identified provides insights into HCC molecular classifications and therapeutic developments for the treatment of liver tumors caused by distinct genetic mutations.
Citation Information: J Clin Invest. 2016. https://doi.org/10.1172/JCI86013.
Citation Information: J Clin Invest. 2016. https://doi.org/10.1172/JCI85226.
In Wilson disease (WD), functional loss of ATPase copper-transporting β (ATP7B) impairs biliary copper excretion, leading to excessive copper accumulation in the liver and fulminant hepatitis. Current US Food and Drug Administration– and European Medicines Agency–approved pharmacological treatments usually fail to restore copper homeostasis in patients with WD who have progressed to acute liver failure, leaving liver transplantation as the only viable treatment option. Here, we investigated the therapeutic utility of methanobactin (MB), a peptide produced by Methylosinus trichosporium OB3b, which has an exceptionally high affinity for copper. We demonstrated that ATP7B-deficient rats recapitulate WD-associated phenotypes, including hepatic copper accumulation, liver damage, and mitochondrial impairment. Short-term treatment of these rats with MB efficiently reversed mitochondrial impairment and liver damage in the acute stages of liver copper accumulation compared with that seen in untreated ATP7B-deficient rats. This beneficial effect was associated with depletion of copper from hepatocyte mitochondria. Moreover, MB treatment prevented hepatocyte death, subsequent liver failure, and death in the rodent model. These results suggest that MB has potential as a therapeutic agent for the treatment of acute WD.
Citation Information: J Clin Invest. 2016. https://doi.org/10.1172/JCI83339.
Persistent hepatitis B virus (HBV) infection is established by the formation of an intranuclear pool of covalently closed circular DNA (cccDNA) in the liver. Very little is known about the intrahepatic distribution of HBV cccDNA in infected patients, particularly at the single-cell level. Here, we established a highly sensitive and specific ISH assay for the detection of HBV RNA, DNA, and cccDNA. The specificity of our cccDNA probe set was confirmed by its strict intranuclear signal and by a series of Southern blot analyses. Use of our in situ assay in conjunction with IHC or immunofluorescence uncovered a surprisingly mosaic distribution of viral antigens and nucleic acids. Most strikingly, a mutually exclusive pattern was found between HBV surface antigen–positive (HBsA-positive) and HBV DNA– and cccDNA-positive cells. A longitudinal observation of patients over a 1-year period of adeforvir therapy confirmed the persistence of a nuclear reservoir of viral DNA, although cytoplasmic DNA was effectively depleted in these individuals. In conclusion, our method for detecting viral nucleic acids, including cccDNA, with single-cell resolution provides a means for monitoring intrahepatic virological events in chronic HBV infection. More important, our observations unravel the complexity of the HBV life cycle in vivo.
Citation Information: J Clin Invest. 2016. https://doi.org/10.1172/JCI83885.
Citation Information: J Clin Invest. 2015. https://doi.org/10.1172/JCI78991.
Wilson's disease (WD) is an autosomal recessive disorder that results in accumulation of copper in the liver as a consequence of mutations in the gene encoding the copper-transporting P-type ATPase (ATP7B). WD is a chronic liver disorder, and individuals with the disease present with a variety of complications, including steatosis, cholestasis, cirrhosis, and liver failure. Similar to patients with WD, Atp7b–/– mice have markedly elevated levels of hepatic copper and liver pathology. Previous studies have demonstrated that replacement of zinc in the DNA-binding domain of the estrogen receptor (ER) with copper disrupts specific binding to DNA response elements. Here, we found decreased binding of the nuclear receptors FXR, RXR, HNF4α, and LRH-1 to promoter response elements and decreased mRNA expression of nuclear receptor target genes in Atp7b–/– mice, as well as in adult and pediatric WD patients. Excessive hepatic copper has been described in progressive familial cholestasis (PFIC), and we found that similar to individuals with WD, patients with PFIC2 or PFIC3 who have clinically elevated hepatic copper levels exhibit impaired nuclear receptor activity. Together, these data demonstrate that copper-mediated nuclear receptor dysfunction disrupts liver function in WD and potentially in other disorders associated with increased hepatic copper levels.


McKenzie Towne School is an elementary school located within the community. The school provides K–4 students with a high quality education close to home. As one of Calgary's newer schools, McKenzie Towne benefits from modern amenities and features. In recent years the residents of McKenzie Towne joined together to successfully raise funds for a school playground, which is now beloved by the students.
David Thompson Middle School challenges students to learn in a meaningful way, and is committed to a positive social and school environment. Students are grouped into learning communities to ensure each student receives the education needed to succeed. A wide variety of complementary courses are available to students, including music and athletics. As David Thompson School is located in Acadia, buses are available for McKenzie Towne students.
Lord Beaverbrook is one of Calgary's major high schools that provides a high quality education to students all across the community. In addition to a strong selection of core courses, Lord Beaverbrook offers a diverse range of electives. These electives allow students to explore various career paths and interests, and develop skill sets that will continue to serve them in the future.


text:
11/1/2018 in Drama by Ani Bundel
Demelza says: "Have Fun In Westeros!" (Photo: Courtesy of Mammoth Screen for BBC and MASTERPIECE)
It looks like Demelza is finished with the memory of Hugh Armitage for good, because actor Josh Whitehouse is officially leaving the world of Poldark (and the BBC) behind. It was announced this week he will be joining Naomi Watts as the first two significant actors of note to take roles in the upcoming prequel for HBO's Game of Thrones, entitled The Long Night.
The Long Night represents a new chapter in HBO's programming, as it is the first TV show spinoff of a successful series on the cable channel. Prior to this, when a show ended on HBO, that was it. Rome didn't get a spinoff called Gaul; The Sopranos didn't have a sequel called Meadow. Oz didn't make a prequel about how all their characters landed in jail. But Game of Thrones is different. It's the series that defines this current era of prestige fantasy television, and regularly gives HBO ratings of a magnitude never seen before. The network was so determined to make this work, they originally commissioned no less than five test scripts, one of which made it to the pilot filming stage. It is being written and directed by Jane Goldman of theKingsman movie franchise, along with original A Song of Ice & Fire author George R.R. Martin.
The good news is, much like the original series, HBO is looking to cast a mix of actors for The Long Night, both known and unknown, and much like the first series, they're drawing heavily on the BBC and ITV stables, as well as a few big screen names. Game of Thrones originally cast everyone from Sean Bean (Sharpe), Charles Dance (The Jewel In The Crown), and Rose Leslie (Downton Abbey). Watts was the first to be cast, as "a charismatic socialite hiding a dark secret." Now Whitehouse, fresh from Cornwall and Poldark, will be joining her.
(Photo: Courtesy of Mammoth Screen for BBC and MASTERPIECE)
According to Deadline, which broke the news:
HBO has set Josh Whitehouse to a lead role in HBO's Game of Thrones prequel pilot from writer Jane Goldman and author/GOT co-executive producer George R.R. Martin that has Naomi Watts heading a fast-forming ensemble cast... The story line and roles are being kept close to the vest at HBO, which would not comment.
The Long Night will put the pre- in prequel in a major way, as its story is set ten thousand years before the events of the current show. Here's the synopsis:
Taking place thousands of years before the events of Game of Thrones, the series chronicles the world's descent from the golden Age of Heroes into its darkest hour. And only one thing is for sure: From the horrifying secrets of Westeros' history to the true origin of the white walkers, the mysteries of the East, to the Starks of legend… it's not the story we think we know.
Not to worry, though, even though the show is set quite far back in time, both the Stark and the Lannister families trace their lineages back to this era. Therefore, there will be some familiar names, if not faces, present. Fans of the show also expect a body count to rival the original, so though Whitehouse and Watts are both set for significant roles, there's no telling how many episodes they will actually survive for. (Bean famously was the face on the side of the bus promoting the original series, and his character was dead before the first season ended.)
Game of Thrones' final season is expected to bow in the spring of 2019. The Long Night, if it makes it out of the pilot stage, should premiere sometime in 2020.
Game of Thrones Poldark Josh Whitehouse
'Poldark' Season 4 Comes to America This Fall
Prepare your emotions: The BBC released their first trailer for Season 4 of Poldark!
It's a New Era in the PBS Trailer for 'Poldark' Season 4
The new PBS trailer for "Poldark" Season 4 is here!
"Poldark" Season 5 continues to into unexplored territory, with a significant - and frankly, unnecessary - story involving a character we just met.

redpajama_set_name: RedPajamaCommonCrawl


text:
Honorable Charles Mok, JP
Charles Mok, is the Legislative Councillor representing the Information Technology Functional Constituency. He has been serving the ICT industry for more than 20 years. He is currently the Vice Chairman of the Professional Commons, Honorary President of the Hong Kong Information Technology Federation and Founding Chairman of the Internet Society Hong Kong.
Charles is active in public services with a view to upholding the core values of Hong Kong of which include democracy, liberty, human rights, rule of law and integrity, and is serving on various advisory bodies in the Hong Kong government, Hospital Authority, WKCDA, higher educational institutions, and etc.
Charles graduated from Purdue University in the United States with his Bachelor and Master degrees of Science in Computer and Electrical Engineering.
Vice Chairman, The Professional Commons
Member, Advisory Committee of MSc Programme in Business Analytics, HKUST Business School
Advisor, Ranking Digital Rights Project, New America Foundation
Member, Advisory Committee of Department of Information Engineering, The Chinese University of Hong Kong
Member, Advisory Committee of MSc Programme in Information and Technology Management, The Chinese University of Hong Kong
Founding Member, Cloud Security Alliance, Hong Kong & Macau Chapter
Honorary Advisor, The Hong Kong Consumer Electronics Alliance
Honorary Advisor, Hong Kong Association of Interactive Marketing
Founding Chairman, Internet Society Hong Kong
Honorary President, Hong Kong Information Technology Federation
Advisor, Hong Kong Internet Service Providers Association
Chairman, The Professional Commons
Chairman, Asian, Australasian and Pacific Islands Regional At-Large Organization (APRALO), Internet Corporation for Assigned Names and Numbers (ICANN)
Vice Chair, Digital, Information and Telecommunications Committee, Hong Kong General Chamber of Commerce
Councillor, Engineers Without Borders
Chair, Health Information Technology Special Interest Division, Hong Kong Computer Society
Chair, Internet Society Hong Kong
Director, Hong Kong Internet Registration Corporation
President, Hong Kong Information Technology Federation
Chairman, Hong Kong Internet Service Providers Association
Co-opted member, The Information Technology Services Governing Committee, Hospital Authority
Member, Information Technology Business Committee, The Hong Kong Council of Social Service
Member, Code of Practice for Recognized Certification Authorities Advisory Committee, OGCIO
Member, Digital 21 Strategy Advisory Committee
Member, Radio Television Hong Kong Programme Advisory Panel
Member, IT Sub-Committee of Senior Citizen Home Safety Association
Member, Information Technology Development Committee, Hong Kong Young Women's Christian Association
Member, West Kowloon Cultural District Authority Consultation Panel
Co-opted Member, Consumer Council
Member, Hospital Authority
Member, Digital 21 Strategy Advisory Committee Members
Member, Transport Advisory Committee
Member, Consumer Council
Member, Trade and Industry Advisory Committee
Part-time Member, Central Policy Unit
Legislative Councillor (Information Technology)
Director, Computancy Limited
CEO, Halo Systems Limited
Deputy Managing Director, HKNet Company Limited
Systems Engineering Manager, SunSoft Inc., USA
Software Consultant/ Software Engineer, Digital Equipment Corp., USA
MSc in Electrical Engineering, Purdue University, USA
BSc in Computer and Electrical Engineering, Purdue University, USA
Wah Yan College, Hong Kong


Back on the market as of April 12th at 8:49am, this home was originally listed on April 12th in 2019. The property is being listed at a price of $389,000 , the same as its original list price. This 2 bedroom, 1 full bath residence is located on Sunnybrook Circle, one of the nicer areas of .
With a total size of 978 square feet, this beautiful home comes in at $397.75 per square foot. That's 19.31% lower than the neighborhood average. There are also 2.00 garage spaces available for parking.
Listing provided courtesy of Kimberly Nguyen at America First Real Estate.


text:
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redpajama_set_name: RedPajamaGithub


text:
AboutMemoirsPoetryBible Study GuidesContact
Hal Upchurch Chronicles
You may interact with this site on its Facebook page.
The book contains "tales" that will not appear on the website.
afterlife ascension big brother blessings boys branded burial calling conscience death ego Emmanuel ethereal family father gratitude history home humor inner conflict life little brother love mystery nostalgia obituary Okinawa one-room school Papa play prayer preach promise prophecy psalm reign resurrection return son struggle teaching thanksgiving varmint whisper work
This website's content may be freely shared for noncommercial use in unaltered form with attribution and a link to randomscreenful.us/halupchurch.
In Lieu of an Obituary
I, Robert Harrell (Hal) Upchurch, the 4th born son of Frank and Winnie Upchurch, was born on a farm near Itasca, Texas, on May 4, 1918, where I was raised as the brother of Harry, Howard, Chester, Alice and Buddy.
On September 4, 1941, in the Belknap Baptist Church in Dallas, Texas, I was married to Mary Geraldine (Jerry) Heath.
I was the father of Hal Rhea and Mary Kay Upchurch, the grandfather of five grandchildren, four great-grandchildren, and the step-grandfather of other dear ones.
In my extended ministry, which spanned more than 70 years, I pastored churches in Texas, Wyoming, and Colorado. I preached, sang, taught, held revivals, bible studies and cowboy camp meetings, and engaged in other church-related activities in 29 of our 50 United States; and in Mexico, Hawaii, Okinawa, Japan, Egypt and Israel; and in Rome, Italy, where people from 32 different nations registered as visitors in the Sunday morning service.
I was the fellow pilgrim of an innumerable host of inexpressibly dear friends and faithful comrades who loved, encouraged, strengthened and blessed me across the 90 years of my life; whose names I have ceaselessly whispered in the ears of our heavenly Father; which, "over there," in our eternal "Zion" I hope to continue doing until time is no more, and all of God's children are safely gathered across "the river that has no bridge," and are numbered among the eternal family of faith in the land of "many mansions;" in which there shall be no more pain, hurting, sickness, suffering, sorrow, separation, loneliness nor death.
In this world I learned, and, for more than 70 years, proclaimed the truth that shall be divinely and repeatedly confirmed in the world that is to come: "To live on in the hearts of those we leave behind is not to die."
And so, my beloved family and my beloved friends: Hold me in your hearts until the Lord sends His seraphic servant to sound His summons for you to come home to Him; and, in the morning, I shall be waiting for you "over there." Selah!
Hal Upchurch, died May 1, 2008
death / life / obituary / old / young
Previous PostThe 23rd Psalm – Study 1 of 12
Next PostThe Whisper


I wanted to have my "smile enhanced" for a long time. After much research surfing the net and speaking with other dental offices, I knew exactly what I was looking for and what training they should have. When I walked into "Doolin Haddad" Advanced Dentistry, and spoke with the staff and met with Dr. Haddad several times, I knew I had found the dentist that I felt comfortable with and had the confidence in to make "my smile happen". I had finally found the place! I am so pleased how my teeth look, it is exactly how I envisioned it would be. I would happily recommend Dr. Haddad and his staff to others who would like to enhance their smile.


text:
class _CAutoLock
{
public:
	_CAutoLock(LPCRITICAL_SECTION csObject) : m_csObject(csObject)
	{
		EnterCriticalSection(m_csObject);
	}

	~_CAutoLock()
	{
		LeaveCriticalSection(m_csObject);
	}
private:
	LPCRITICAL_SECTION m_csObject;
};

CWizard::CWizard(LPUNKNOWN pUnk, HRESULT *phr)
        : CUnknown(NAME("Display Server"), pUnk)
        , m_pRenderEngine(NULL)
        , m_bInitialized (FALSE)
		, m_bExtRenderEng (FALSE)
		, m_pDispSvrDebug(NULL)
{
	InitializeCriticalSection(&m_ObjectLock);
	// because CWizard is a singleton in DispSvr global, we add a reference
	// here to prevent others from releasing the instance.
	AddRef();
}

CWizard::~CWizard()
{
	ReleaseDebugObject();
    Terminate();
	DeleteCriticalSection(&m_ObjectLock);
}

///////////////////////// IUnknown /////////////////////////////////////////

STDMETHODIMP CWizard::NonDelegatingQueryInterface(REFIID riid, void ** ppv)
{
    HRESULT hr = E_NOINTERFACE;
    *ppv = NULL;

    if (riid == IID_IDisplayServer)
    {
        hr = GetInterface((IDisplayServer*) this, ppv);
    }
    else if (riid == IID_IDisplayLock)
    {
        hr = GetInterface((IDisplayLock*) this, ppv);
    }
    else
    {
        hr = CUnknown::NonDelegatingQueryInterface(riid, ppv);
    }
    return hr;
}

///////////////////////// IDisplayServer /////////////////////////////////

STDMETHODIMP CWizard::Initialize(
    DWORD dwFlags,
    HWND hWnd,
    IDisplayRenderEngine *pRenderEngine)
{
    HRESULT hr = S_OK;
    HWND hwndRE = NULL;

	CreateDebugObject();

    if (m_bInitialized)
    {
        DbgMsg("CWizard::Initialize: Wizard is already initialized");
        return S_FALSE;
    }

    if (FALSE == IsWindow(hWnd))
    {
        DbgMsg("CWizard::Initialize: Invalid handle to the video window");
        return E_INVALIDARG;
    }

    CAutoLock Lock(&m_ObjectLock);

    try
    {
        // initialize render engine. We assume that if custom render engine is provided,
        // it is already initialized
        m_pRenderEngine.Release();
        if (pRenderEngine) // user specified customized render engine
        {
            // check that pRenderEngine was initialized and they point to the same window
            hr = pRenderEngine->GetDisplayWindow(&hwndRE, NULL);
            CHECK_HR(hr, DbgMsg("CWizard::Initialize: Failed to get window handler from the provided RenderEngine, hr = 0x%08x", hr));

            hr = (hwndRE != hWnd ? E_FAIL : S_OK);
            CHECK_HR(hr, DbgMsg("CWizard::Initialize: specified render engine points to a different window than wizard"));

            m_pRenderEngine = pRenderEngine;
			m_bExtRenderEng = TRUE;
			if (m_pDispSvrDebug)
			{
				m_pDispSvrDebug->SetRenderEngine(m_pRenderEngine);
			}
        }
        else
        {
			m_pRenderEngine = new CRenderEngine(NULL, NULL);
			CHECK_HR(hr, DbgMsg("CWizard::Initialize: Failed to create DisplayRenderEngine object, error code %08x", hr));
			if (m_pDispSvrDebug)
			{
				m_pDispSvrDebug->SetRenderEngine(m_pRenderEngine);
				m_pDispSvrDebug->SetInitFlags(dwFlags);
				HANDLE hDispSvrDbgMutex = NULL;
				hDispSvrDbgMutex = ::CreateMutex(NULL, FALSE, DispSvrDbgGlobalMutexID);
				if (GetLastError() == ERROR_ALREADY_EXISTS) //DispSvr Debug Tool is enabled and want to modify initflags
				{
					if (IDOK == ::MessageBox(hWnd, _T("Please use DispSvr debug tool to modify init flags before you click OK or just Cancel it"),
						_T("DisplayServer Debug Tool Detected"), MB_OKCANCEL|MB_ICONINFORMATION|MB_SYSTEMMODAL))
					{
						m_pDispSvrDebug->GetInitFlags(&dwFlags);
					}
				}
				::CloseHandle(hDispSvrDbgMutex);
			}
			hr = m_pRenderEngine->Initialize(hWnd, 0, 0, this, dwFlags);
			CHECK_HR(hr, DbgMsg("CWizard::Initialize: failed to initialize default render engine, hr = 0x%08x", hr))
		}

        hr = m_pRenderEngine->SetDisplayServer(this);
        CHECK_HR(hr, DbgMsg("CWizard::Initialize: failed to set Display Server, hr = 0x%08x", hr));

        m_bInitialized = TRUE;
    }
    catch (HRESULT hrFailed)
    {
		if(m_pDispSvrDebug)
			m_pDispSvrDebug->SetRenderEngine(NULL);
		// m_pRenderEngine must be released if initialization failed
		m_pRenderEngine.Release();
		hr = hrFailed;
    }
    return hr;
}

STDMETHODIMP CWizard::Terminate()
{
    HRESULT hr = S_OK;

    try
    {
        // Unadvise render engine
		if (m_pRenderEngine)
		{
			hr = m_pRenderEngine->SetDisplayServer(NULL);
			CHECK_HR(hr, DbgMsg("CWizard::Terminate: failed to unadvise WizardOwner for render engine, hr = 0x%08x", hr));

			if (!m_bExtRenderEng)
			{
				hr = m_pRenderEngine->Terminate();
				CHECK_HR(hr, DbgMsg("CWizard::Terminate: failed to terminate render engine, hr = 0x%08x", hr));

				m_pRenderEngine.Release();
			}
			else
			{
				hr = m_pRenderEngine->StopRenderingThread();
				m_pRenderEngine = NULL;
			}
		}
		//Release RenderEngine ref count in DispSvr Debug
		if (m_pDispSvrDebug)
			m_pDispSvrDebug->SetRenderEngine(NULL);

		m_bInitialized = FALSE;
    }
    catch (HRESULT hrFailed)
    {
        hr = hrFailed;
    }
    return hr;
}

STDMETHODIMP CWizard::BeginDeviceLoss()
{
	return E_NOTIMPL;
}

STDMETHODIMP CWizard::EndDeviceLoss(IUnknown* pDevice)
{
	return E_NOTIMPL;
}

STDMETHODIMP CWizard::GetRenderEngine(IDisplayRenderEngine** ppRenderEngine)
{
    if (!ppRenderEngine)
    {
        DbgMsg("CWizard::GetRenderEngine: first argument is NULL");
        return E_POINTER;
    }

    if (!m_bInitialized)
    {
        DbgMsg("CWizard::GetRenderEngine: Method 'Initialize' was never called");
        return VFW_E_WRONG_STATE;
    }

    *ppRenderEngine = m_pRenderEngine;
    (*ppRenderEngine)->AddRef();
    return S_OK;
}

STDMETHODIMP CWizard::GetMessageWindow(HWND* phwnd)
{
	if (!m_bInitialized)
	{
		DbgMsg("CWizard::GetMessageWindow: Method 'Initialize' was never called");
		return VFW_E_WRONG_STATE;
	}

	return m_pRenderEngine->GetMessageWindow(phwnd);
}

STDMETHODIMP CWizard::SetMessageWindow(HWND hwnd)
{
	if (!m_bInitialized)
	{
		DbgMsg("CWizard::SetMessageWindow: Method 'Initialize' was never called");
		return VFW_E_WRONG_STATE;
	}

	return m_pRenderEngine->SetMessageWindow(hwnd);
}

STDMETHODIMP CWizard::Lock()
{
	EnterCriticalSection(&m_ObjectLock);
    return S_OK;
}

STDMETHODIMP CWizard::Unlock()
{
	LeaveCriticalSection(&m_ObjectLock);
    return S_OK;
}

STDMETHODIMP CWizard::TryLock()
{
	return TryEnterCriticalSection(&m_ObjectLock) == 0 ? E_FAIL : S_OK;
}

HRESULT CWizard::CreateDebugObject()
{
	if (m_pDispSvrDebug)
		return S_FALSE;
#if defined(_DEBUG) || !defined(TR_ENABLE_NEWMACROS)
	m_pDispSvrDebug = new CDispSvrDebug(NULL, NULL);
	if (m_pDispSvrDebug)
	{
		m_pDispSvrDebug->AddIntoROT();
		return S_OK;
	}
	else
		return E_OUTOFMEMORY;
#endif
	return S_FALSE;

}

HRESULT CWizard::ReleaseDebugObject()
{
	if (m_pDispSvrDebug)
	{
		m_pDispSvrDebug->RemoveFromROT();
		SAFE_RELEASE(m_pDispSvrDebug);
		return S_OK;
	}
	else
		return S_FALSE;
}


text:
https://www.fairplanet.org/op-ed/oh-jeremy-corbyn/
All opinions in this section are those of the author(s) and do not necessarly reflect the opinion of FairPlanet.
Oh, Jeremy Corbyn
Ithamar Handelman-Smith
On 23 April 1977, the British far right and Neo-Nazi National Front decided to march from Duckett's Common near the Turnpike Lane tube station in North London down Wood Green, a busy London High Road known for its diverse migrant communities of both Turkish and Caribbean origin, just around the corner from the Jewish Ultra-Orthodox neighborhood of Stamford Hill. The fascists had planned to stir some provocation in the area and the proximity to the anniversary of Hitler's birthday was no coincidence. But only a fraction of the twelve hundred National Front marchers made it to the concluding rally, because it was opposed by a far greater number of anti-racist opposition, including delegations from the local Borough of Haringey Labour Party, trade unionists, the Indian Workers' Association, local West Indians, members of Rock Against Racism and the Socialist Workers Party.
While Communists and churchmen addressed a rally at one end of Duckett's Common, a contingent composed of more radical elements in the crowd broke away and subjected the NF column to a barrage of smoke bombs, eggs and rotten fruit. 81 people were arrested, including 74 anti-fascists. One of the organizers of the anti-fascist counter demonstration, later known as "The Battle of Wood Green" was one Jeremy Corbyn, then a Labour Councillor and a trade union official. The fascists never returned in significant number to the Borough.
40 years on, the Jewish Chronicle, Britain's biggest Jewish newspaper, in a front-page editorial directed at non-Jews, has pleaded with the public not to vote for Jeremy Corbyn, accusing him of "racist views".
The Jewish Chronicle said that throughout his career Mr Corbyn had "allied with and supported antisemites," and accused him of having "actively impeded action against racists." The newspaper went on to highlighted a poll, which found that nearly half of the Jewish community said they would seriously consider emigrating if Mr Corbyn became prime minister.
This front page of the Jewish Chronicle is merely a follow up. In July 2018 we saw a joint editorial published with similar front pages for the Thursday edition of the three Jewish newspapers in the United Kingdom (The Jewish Chronicle, Jewish News and Jewish Telegraph), warning that a Labour-led government would be an "existential threat" to the UK Jewry. The editorial continued attacking the Labour party's decision not to fully absorb an internationally accepted IHRA definition of antisemitism into its code of conduct, and its wider record on the issue since Corbyn became leader in 2015.
40 years ago, Mr. Corbyn would have never imagined that he would be the centre of such accusations. But the fact is that the UK's Jewish community fears Corbyn and sees him as a real threat. How did this happen?
The conservative media, both in the UK and Israel, have long targeted Corbyn as an anti-Semitic far-left leader. In Israeli public opinion, shaped by Prime Minister Benjamin Netanyahu and his peers, any criticism of Israeli policies (mainly over the issue of the Israeli occupation and mistreatment of the Palestinians) is perceived as a so called "new form" of antisemitism. In a very unusual attack on an opposition leader of a foreign country, Israeli Prime Minister Benjamin Netanyahu harshly criticized Corbyn's participation in a memorial event in Tunisia in 2014. On the evening of 13 August, 2018, Netanyahu tweeted that "The laying of a wreath by Jeremy Corbyn on the graves of the terrorist who perpetrated the Munich massacre and his comparison of Israel to the Nazis deserves unequivocal condemnation from everyone – left, right and everything in between."
That was, of course, pure populist blunder, and it is almost ironic to hear it coming from Netanyahu, a man who aligned himself with some of the worst far-right, "old school" Anti-Semite leaders of eastern and central European countries, like Poland and Hungary. A man who said in front of the world Zionist congress in October 2015 that "Hitler only wanted to expel the Jews, but Jerusalem's Grand Mufti convinced him to exterminate them," a claim that was rejected by most accepted Holocaust scholars.
Both the British and Israeli media was picking over the conflicting accounts of what Corbyn was doing at a Tunisian government-organized conference, which included a memorial for those killed in a widely-condemned 1985 Israeli air strike. It was alleged that Corbyn laid a wreath at the grave of a PLO leader who helped plan the killing of Israeli athletes forty six years ago, which Corbyn denied. It is important to mention that the said leader was Salah Mesbah Khalaf, also known as Abu Iyad ,who was Yasser Arafat's second in command, who denied being involved with the black September attacks.
It is also worth mentioning that Israel has signed a peace process with the PLO, and Netanyahu himself met Arafat and shook his hand. So how come Corbyn's supposed laying of a wreath over the PLO second in command's gravestone is an Anti-Semitic incident that deserves "unequivocal condemnation"?
But this sort of rhetoric by conservative leaders (both Jews and Non-Jews) against Jeremy Corbyn has managed to convince the British Jewry that Corbyn poses a real "existential threat".
Since Mr. Corbyn's surprising victory in the Labour leadership contest in 2015, allegations of anti-Semitism have increasingly tainted his service. While some Jews accuse Mr. Corbyn of outright hostility, in spite of his continuous denials, others blame him for tolerating fellow left-wingers with more radical so-called anti-Zionist views. Is Corbyn anti-Semitic? Of course not. Being a staunch critic of Israel doesn't make you an anti-Semite, and this confusion must be put to an end.
The media was outraged when Corbyn challenged some of the IHRA definitions of antisemitism, especially the definition states that some criticism of Israel could be anti-Semitic, such as: "Denying the Jewish people their right to self-determination, e.g., by claiming that the existence of a State of Israel is a racist endeavor". Several months later, the EU issued a new declaration questioning that very same definition (and, of course, enraging Netanyahu).
Now, one can blame Jeremy Corbyn for many things: his lack of leadership addressing those allegations of antisemitism in the Labour party or how poorly he had dealt with disturbing comments made by high-ranking Labour party members, from the likes of Mr. Ken Livingstone, former Mayor of London, or MP Naz Shah.
Livingstone stated in a BBC interview that, "When Hitler won his election in 1932 his policy then was that Jews should be moved to Israel. He was supporting Zionism before he went mad and ended up killing six million Jews." And while Livingstone was suggesting that Hitler was a Zionist, Shah suggested that the whole state of Israel should "relocate to the United States," adding: "problem solved." It took Mr. Corbyn quite a while to react to those comments and to act accordingly. Still, he could not bring himself to expel Livingstone, his long-term ally, for his plainly offensive comments. Livingstone has since resigned.
One can also definitely disagree with the way Corbyn has dealt with Brexit, but to blame him for any sort of racism and as a "threat" to Jewish life in the UK will be absolutely absurd. It will be absurd because the problem of antisemitism, real and terrifying as it is, is not unique to the Labour party. In fact, the problem is more severe in all the other parties running now for the UK general elections, but, somehow, nobody seems to talk about it. The antisemitism Barometer, a 2017 report, suggests that the problem is far worse among parties on the right.
The report suggested that 32 per cent of Labour supporters agreed with one of the anti-Semitic statements they were presented with. That is somewhat lower than Conservative supporters (40 per cent) and UKIP (which is now the Brexit party) with an average of 39 per cent. So, why does the press, both Jewish and non-Jewish, only targets the Labour party?
On a personal note: After more than 6 years in Paris, I had moved to London about two years ago. I teach at a Jewish school, and I am a member of the local Jewish community. I know that they are truly worried about Mr. Corbyn's-led Labour party, but I cannot understand how this came to pass.
Addressing the ongoing saga of antisemitism, Corbyn opened his column in The Guardian, on Friday, 3 August, with these very words: "I have spent my life campaigning for recognition of the strength of a multicultural society. Britain would not be Britain without our Jewish communities. Our country would be unimaginable without the immense contribution made by Jewish men and women to every part of our national life. I do not, for one moment, accept that a Labour government would represent any kind of threat, let alone an 'existential threat' to Jewish life in Britain."
Image: Mark Holt
Climate breakdown, decision-makers, we need you to wake up, to rise up!
Mara Dolan
org:
The Women's Major Group
Women and non-binary folks are among the first to be affected by the climate crisis. True climate justice would involve rectifying centuries of gender-bias.
On Tyranny: A close inspection of Israel's Prime Minister Benjamin Netanyahu
Israel's prime minister Benjamin Netanyahu casts a dark shadow over the the future of Israeli democracy, as western democracies face similar challenges.


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Home > YHRDLJ > Vol. 8 (2005)
Yale Human Rights and Development Journal
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The Granite Chief Wilderness Area is a 25,000-acre section of the Tahoe National Forest. Established in 1984, the park includes glaciated valleys, exposed granite formations, and 9,000-foot peaks. One of the most beautiful and thrilling hikes in the wilderness area is the 4.8-mile Five Lakes Trail. Few other trails in Tahoe exhibit the secluded charm of this location without an overnight camp in the middle.
The Five Lakes Trailhead is located right off the main Alpine Meadows road. Park across the street and prepare yourself for a strenuous climb of 1,200 feet in a little less than 2 miles. Along the way you will be presented with views of Alpine Meadows and the surrounding mountains. Take note of a phantom chairlift, which is rumored to be a future connection between Alpine and Squaw Valley. Once you have reached the Granite Chief Wilderness sign, your climb is finished.
Follow the trail a bit further until you reach the first lake. From here, there are many smaller trails meandering around and between the lakes. Take your time and explore each one to find your favorite. Once you are ready to return, you can use the top of the chairlift as a marker to find your way back to the main trail. Return to the trailhead using the same path.
No loop. Can be crowded.


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Right now I only have this red one listed, but I will be adding more colors over the next couple of weeks.


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France / Red
Domaine des Pierres Seches (Sylvain Gauthier), Saint Joseph 2018
After wine studies in Beaune, winemaker Sylvain Gauthier decided to explore native Rhône grapes first with Michel Chapoutier and then with Stéphane Robert, before he was ready to start his own project in the true center of the Saint-Joseph appellation. He founded his micro-domaine in the village of Cheminas in 2007, the name "pierres séches" inspired by the hand-built, ancient stone walls that support vineyard terraces on the steep slopes of the northern Rhône. Farming organically and using little sulfur at bottling, Sylvain's wines are vibrantly flavored and energetically spiced—in sum, serious northern wines that have quickly become a must have from an up-and-coming talent.
A stunning Saint-Joseph that captures the heart and soul of this appellation — indeed, it hails from villages that make up the southern part of Saint-Joseph, its original borders, where fruit is riper, earthy and very profound. Winemaker Sylvain Gauthier selects fruit from mostly older vines for this gem of a northern Syrah.
Northern Rhône
Estate hillside vineyards face south/southeast in the communes of Sarras, Arras-sur-Rhône and Vion. Soils are mostly decomposed granite; in Vion, slopes have sandier granite soils. All these areas are part of the southern end of the Saint-Joseph appellation.
Partially destemmed (90%); fermented in temperature-controlled, stainless steel tanks on indigenous yeasts. Aged for one year in older French oak barrels (four years old). Bottled unfined, with minimal added sulfur.


I'm so happy and feel so fortunate to be a part of this wonderful program.
Smarty Pants Yoga may look like a typical yoga class – with breathing and stretching – but there's also a serious lesson to be learned.
Each class centers on a different issue told through the story of a strong female character. Girls listen and discuss the good and the bad and afterwards the story is retold through yoga.
The classes give young ladies a chance to find their voice and express it in the right way.
Annie Warshaw is the founder and CEO – and a former 2nd grade teacher who wanted to get in front of problems before young girls were faced with handling them.
In its second year in business, Smarty Pants is now teaching 1st through 5th graders in 40 different city and suburban schools and is heavily involved in park districts across the area.


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Q: SQL Select rows where col1 or col2 equals variable So I want to select rows from table where col1 or col2 equals to variable, but if there is already row selected where col1 equals to variable (variable X) and col2 is anything else (variable Y) then it won't select another row where col2 equals to variable X and col1 equals to that variable Y. Everything ordered by column TIME descending.
Let's say this is my table:
COL1    COL2    TIME    COL4
1       2       0       A
1       2       1       B
2       1       2       C
1       3       3       D
3       1       4       E
4       2       5       F
3       4       6       G
1       2       7       H
4       1       8       I

And let's say that variable X equals to 1, then I want to have these rows:
COL1    COL2    TIME    COL4
4       1       8       I
1       2       7       H
3       1       4       E

So it won't show me this row
COL1    COL2    TIME    COL4
2       1       2       C

because there is already a combination where col1/col2 is 2/1 or 1/2.
Sorry if I explained it in a bad way, but I can't think of better explanation.
Thank you guys.

A: EDIT: I posted this answer when it was thought that OP's database was SQL Server. But as it turns out, the database is MySQL.

I think this query should do it:
select t.col1, t.col2, t.time, t.col4
  from (select t.*,
               row_number() over (
                 partition by
                   case when col1 < col2 then col1 else col2 end,
                   case when col1 < col2 then col2 else col1 end
                 order by time desc) as rn
          from tbl t
         where t.col1 = x or t.col2 = x) t
 where t.rn = 1
 order by t.time desc

The key part is defining the row_number partition by clause in such a way that (1, 2) is considered equivalent to (2, 1), which is what the case statements do.  Once the partitioning works correctly, you just need to keep the first row of every "partition" (where t.rn = 1) to exclude duplicate rows.

A: Making a couple of key assumptions...
SELECT a.*
  FROM my_table a
  JOIN
     ( SELECT MAX(time) time
         FROM my_table
        WHERE 1 IN (COL1,COL2)
        GROUP
           BY LEAST(col1,col2)
            , GREATEST(col1,col2)
     ) b
    ON b.time = a.time;

redpajama_set_name: RedPajamaStackExchange


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Q: iOS Swift code freezes with NSURL when sent from foreground to background to foreground again with 100% loss connection I have been developing with Swift for 6 months so a new user. The app I'm working on has a focus on poor connections and slow speeds. My app freezes under the following conditions.
I have a JSON query to get data from my server, it uses NSURL / NSData. If I have a connection it works, if I have no connection it fails as expected and I report an error to the user that there is no connection. But:
If the connection has 100% loss (you can simulate this via the developer settings within the phone, Network Link Conditioner) the query runs and my app shows an activity indicator. You then press the home button to put the app into background and then click the app icon to open it again. The activity screen is still displayed but the display is frozen. The activity indicator doesn't spin and the battery icon and clock update but draw on top of each other (there is no refresh whatsoever).
After another 30 seconds or so the app terminates. I expect watchdog is killing the app due to the freeze.
If I run the same process with my phone connected to Xcode the app doesn't terminate. I assume watchdog doesn't kill tasks when running via Xcode.
This may seen like a rare occurrence but I would like to try a catch this bug / freeze in my code but as I cannot get an errors displayed it is very hard to do.
Has anyone seen this before? Do you know the cause?
EDIT
Fails with sending or receiving data via JSON, as my sending code is simpler here is the code:
func sendSeverV2(theUrl: String, parameters: String) -> String {

    // build the url for a GET request
    var status = "OK"
    let parameters2 = parameters.stringByAddingPercentEncodingWithAllowedCharacters(.URLHostAllowedCharacterSet())!

    let urlWithParams = "\(theUrl)?\(parameters2)"
    let myUrl         = NSURL(string: urlWithParams)
    let data          = NSData(contentsOfURL: myUrl!)

    guard data != nil else {
        return "Error"
    }

    do {
        let object = try NSJSONSerialization.JSONObjectWithData(data!, options: .AllowFragments)

        if let jsonData = object as? [String: AnyObject]
        {
            status = jsonData["Status"] as! String
        }
        } catch {
            // report error

        }

    if status == "Error"
    {
        print(" JSON fetch had an error for \(urlWithParams)")
    }

    return status

}

EDIT: This function is used for many calls back to the server. Some run on a non main thread. But there are cases when I have this on the main thread. My reason (which may be due to my inexperience) is I may have a settings screen where the user can opt-in or opt-out of email alerts. I need to ensure that the user knows that the the settings have been applied. It would not be good for the user to opt-out of an email alert for the server call to fail but the user thinks it worked. So in these cases the user may have to wait a few seconds on a slow connection or wait for a timeout on a 100% loss connection so the app can display, "connection error".


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text:
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California fitness
Clark hatch
Gym going
HomeGym goingClark hatchClark Hatch Fitness Center in Malaysia
Clark Hatch Fitness Center in Malaysia
Clark Hatch Fitness Center is an established fitness company in Asia with more than 40 years of history. The first center was set up in Tokyo before it moved to Cambodia, China, Guam, Hawaii, India, Indonesia, Korea, Malaysia, Nepal, Philippines, Singapore, Taiwan, Thailand, and Vietnam. However, in Malaysia, the number of Clark Hatch Fitness Center has reduced from 13 to 11 centers.
I joined Clark Hatch in year 2003 and it is my first gym.
It was there where I learn about weight lifting, built my muscles and increased my weight (I was underweight then). It was also there where I know lots of friends and make some gay encounters which I never forget.
In Malaysia, after the exodus of its members to other gyms, Clark Hatch has tried hard to catch up lately. It has introduced new membership packages for Klang Valley members:
Titanium – Members are entitled to all clubs including the Hilton / Le Meridian KL Sentral fitness center
Platinum – Members may use Mutiara Crowne Plaza, Mont Kiara, PJ Hilton and all Gold membership locations
Gold – Members are entitled to use the centers at Crown Princess, Legend and Sheraton Subang
Home Based (if I remember correctly, it is called Executive) – Members can used only one club
Regardless of the package, you can use whichever centers in overseas. I had Subang Sheraton home based membership. When I were in Bangkok, I could go to any of the six Clark Hatch branches in Bangkok.
As for the monthly fees, they vary from location to location. For example, the monthly fee is only about RM120 for Subang Sheraton home based package, but it can be as high as RM160 for Mont Kiara home based package. Typically, the Titanium is the most expensive and heard that it is close to RM200 per month.
Members are not forced to sign up for yearly contract. For those who can afford to pay in one lump sum for 1-year package, they will enjoy the typical 9 months + 3 months promotion during year end. In other words, you pay for 9 months and you will be given 3 months free. The joining fee is normally not waived and it is between RM300 to RM500 depending on availability of promotion too.
Most Clark Hatch Fitness Centers are attached with hotels. Some of the hotels with Clark Hatch Fitness Centers are Hilton KL Sentral/ Le Meridien, Crown Princess, Mutiara Kuala Lumpur, Hilton Petaling Jaya, Sheraton Subang, Hilton Kuching and Sheraton Penang Hotel. It is a win-win situation for both the clubs and the hotels. The management, machines and instructors are provided by the clubs whereas the hotels have the swimming pools, laundry services (for the complimentary sports attire and towels), security guards and hotel guests.
In terms of marketing, Clark Hatch is not as aggressive as California Fitness, Celebrity Fitness and True Fitness. It does not have a dedicated sales team. The front desk person is the one who will explain the packages.
When I spoke to one of the fitness instructors, was told few members have left the club too. Most of them have joined Celebrity Fitness and True Fitness. In fact, she has been head hunted by one of the clubs. But, for the time being, she decided to stay. Reason being, she has got used to the club management and members. The company subsidizes the parking fee and it provides the meal allowance to the staffs.
I hope that Clark Hatch will be able to compete. It caters to the people who prefer much privacy with quiet environment. The market which it serves is different from others. Hotel guests and loyal members will be the supporters for its survival.
Review of Clark Hatch Fitness Center at Subang Sheraton Hotel
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