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Asbestos, mould: home and work hazards
Hazard recognition is the key starting point to managing health and safety risks, whether at home or at work. Two hazards that present real danger at home or at work are asbestos and mould
Asbestos and mould are a danger at home and in the workplace.
By Glyn Jones
Opinion 02 Nov 2020
Neither asbestos nor mould are new hazards, but they are both often overlooked leading to unnecessary exposure and the associated health risks and concerns of friends, family and colleagues at work. Exploring these two hazards, we can be reminded of strategies for effective hazard control and risk reduction.
Asbestos is commonplace in our homes, offices and most buildings built before 1995. Asbestos is a group of minerals that occur naturally as bundles of fibres. It was once dubbed the "miracle fibre" for its strength, insulation properties and ability to resist corrosion and fire. Asbestos is typically present at a concentration of one per cent to 80 per cent in many common construction materials such as insulation, ceiling tile, floor tiles, texture or stipple coat and cement board. We now know asbestos is extremely dangerous if inhaled and exposure can cause disease and early death.
When an asbestos-containing product is disturbed, asbestos fibres are released into the air. Breathing asbestos fibres creates the risk of developing diseases including asbestosis, lung cancer and mesothelioma. Asbestosis is a buildup of scar-like tissue in the lungs that results in loss of lung function that often progresses to disability and death. Asbestos also causes cancer of the lung itself and a rare but deadly form of cancer of the lung lining, or pleura, called mesothelioma. This is a fatal malignant condition that is not treatable.
The control of the asbestos hazard is quite simple. Assess or survey buildings to determine which materials contain asbestos and then minimize the disturbance of these materials. This requires careful sampling of suspect materials for analysis in a laboratory. Hire the services of an industrial hygienist to do this work. If these materials will likely be impacted by renovations or site improvements, seek the advice and input of an industrial hygienist expert in asbestos management. They can help ensure a contractor capable and experienced in handling asbestos can be retained to properly remove the material before work continues.
Mould is naturally occurring and will grow anywhere there is moisture or an uncontrolled water event. A health hazard is created when water is not controlled and mould is allowed to grow indoors. This growth is associated with mould particle production including mould spores and mould fragments. Scientific research on the health effects of mould exposure is ongoing, but some facts are known. The most common health effects of mould exposure include allergic reactions, skin or mucous membrane infections, increased asthma attacks and skin, eyes, nose and throat irritation.
If left unchecked, mould growth can cause significant building damage. Uncontrolled mould growth can eventually cause structural damage to a wood-framed building, weakening floors and walls as it feeds on moist drywall and wooden structural members.
The control of mould and its associated health risks involves the control of moisture. Be on the lookout for water damage, leaks or excessive moisture, and be sure to clean up all spills immediately. If you suspect mould in your workplace, ask yourself these questions:
Has there been a recent water event or is there visible water damage anywhere?
Are there building materials around that have been wet for more than a few days?
Does the building have a history of moisture issues?
Are workers complaining of musty, mouldy smells?
Is anyone reporting symptoms that could be associated with mould?
If you answer yes to any of these questions and are concerned, an industrial hygienist can test surfaces or the air to measure for mould.
To help prevent mould at home and in the workplace, follow these basics tips:
Repair any plumbing problems immediately and properly.
Maintain the building humidity to between 30 per cent and 60 per cent.
Regularly inspect the building's heating, air conditioning and ventilating systems.
Manage rain and snow-melt runoff and ensure adequate drainage is around the building.
Vent moisture from human activities such as cooking and showering directly outside of the building.
We need to remind our colleagues that the hazards of asbestos and mould are commonplace at home and work and that by following a few simple strategies the hazards can be controlled. Let us look around our homes and workplaces and if need be assess the hazards and implement a well-thought-out control strategy.
Glyn Jones is a partner at EHS Partnerships Ltd. in Calgary. He is a consulting occupational health and safety professional with 30 years of experience. He also provides program design and instructional support to the University of New Brunswick's OHS and Leadership Development certificate programs. He can be reached at [email protected] or you can follow him on Twitter at glynjones_ehsp.
This article originally appeared in the Nov/Dec 2020 issue of COS.
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Have you ever been so sad and alone that you wish every friend you've ever had could be by your side? Send out the distress signal to all of your friends that you need to be cheered up, and fast! Your friends will be rushing to your side when you send the very sad emoji across your social media pages and beyond. They will know how important your wellbeing is, and they'll want to be part of helping you heal. Maintaining friendships is a crucial part of life, and you'll know who your real friends are in times of need.


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Managing technology-related risks in the workplace
In our last article, we looked into how to drive efficiency with information technology as well as its benefits. As technology continues to advance and companies embrace the transformation that comes with information technology, they must also be aware of the pending risks associated with it. Today, we examine some of the risks associated with integrating information technology into a business's core operations.
Information technology has penetrated deep into the personal and corporate world. In the same way, the exposure to the risk associated with technology has also increased over time.
In a company, these risks are capable of disrupting the entire operation if they are not properly handled.
What are the risks associated with technology integration in the workplace?
Generally, risks are considered as the possibility of something wrong happening. However, when it comes to information technology, risks can represent security threats posed to a business, its components, information, system and processes, for example, phishing, hacking, data loss, security outages. The most prominent technology risk for both small and large companies is data and privacy breach.
To further understand the risks associated with information technology in the workplace, it is important to understand the internal and external factors that may trigger them in the first place.
Internal factors
These are activities within the company that may directly or indirectly expose the company to risks associated with technology.
Individual actions: people within a company (usually the employees) may indirectly be involved in increasing exposure to risk through their activities/actions or nonchalant behaviour when handling sensitive information or the company's hardware. On the other hand, risk exposure may be the result of a deliberate act on the part of the employees, such as fraud, sabotage, vandalism and theft.
Inadequate internal processes: these types of risks occur when a proper structure is not established within the company to protect it from direct or indirect threats, for example, a responsive system for reporting suspicious activities or an automatic system shutdown when a software component is compromised.
External factors
These are activities that pose threats to security systems (IT) and usually are beyond the control of the company, for instance, the occurrence of a natural disaster, cyber-attacks or activities arising from other service providers.
How to manage workplace IT-related risks
Technology-related risks in the workplace are sometimes inevitable as many components and factors could be behind them. However, there are specific actions that can be taken to minimise risks. Precautionary measures taken will differ from company to company depending on the level of the technology integration being adopted and these include the following:
Identifying the risk
This involves searching for areas/functions within the company that may easily be compromised. A good way to go about this is to understand what exactly may be at risk, which in most cases are the company's assets such as business data and hardware.
Analysing the risk
Upon the successful identification of risk factors, both within and outside the company, the next step would be to analyse them and assess the impact they may have on operations. Ranking in terms of priority will help the company streamline what measures to invest in.
Developing a business continuity plan
In a situation where a risk cannot be avoided or controlled, a business continuity plan should be in place to ensure mitigating actions can be implemented rapidly. The essence of a business continuity plan is to make sure the company does not lose time, resources and revenues when a component is down.
Monitoring and evaluating the performance of risk management measures
Managing risk is a continuous activity that must be frequently reviewed to ensure effectiveness and efficiency.
Other ways to reduce the occurrence of risk include:
Ensure employees understand and implement security standards when handling the company's information, software and hardware. This can be achieved through training.
Frequently update software- Keeping software up to date will ensure security flaws are corrected.
Use strong passwords and enable two-step verifications for sites and applications. Keep these passwords safe and change them regularly.
In summary, threats associated with information technology may be inevitable but companies should seek to familiarize themselves with IT precautionary measures which must be incorporated as standard procedures.
We, at the OVAC Group, can analyse your business IT structure to discover areas that need improvement and provide insights on how to go about setting up the right security measures. Please email us today at enquiries@ovacgroup.com for a free consultation.
Risk tech

redpajama_set_name: RedPajamaCommonCrawl


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"Don't panic," Vector whispered under his breath, which did more to put Lachlan on edge than it reassured him.
"Why?" he asked, turning to the werewolf. He jumped a little when the other man grabbed his hand and squeezed his fingers. It sent a flutter of anxious tingles through Lachlan's arm and made his stomach jump. He would have blushed if he hadn't already been sweating under the outrageous summer sun. Wasn't it supposed to rain on the Fourth of July? It always had before.
Instead of answering, Vector straightened his shoulders and greeted the woman approaching them across the field—he was exaggerating when he called it a field, but this deep in the city, it felt like a field to have such an extravagantly large backyard. Lachlan had sort of gotten the impression that Vector came from a comfortably well-off family, but he was starting to reassess just how comfortable from the looks of this house, as well as the townhouse in Upper Queen Anne Hill.
The woman—she was half a head shorter than Vector, but not too much shorter than Lachlan himself—had dark hair and pale blue eyes that shone almost grey from her pale skin. An air of authority weighed down the lines of her shoulders, and Lachlan couldn't miss the way the other members of the pack unconsciously shifted around her, moving out of the way without the woman having to make a sound. She stopped in front of them, eyes flicking down to their linked hands, brushed across Lachlan's face, and settled on Vector.
"Auntie," the wolf said, temporarily letting go to lean down and wrap her up in a brief hug.
Lachlan twitched—this much be the pack matriarch, the alpha: Teagan Clanahan.
Teagan held out her hand for him to shake. Lachlan's own palms were sweating, both from the heat as well as nerves. He shook her hand firmly, trying not to let his nerves show.
"So I've been told," he said, swallowing as she turned their hands and covered the back of his with the palm of her other hand. There was something possessive about the gesture and the way she swept her eyes over him once before staring again. It felt a little bit like she was attempting to peer into his soul and it made Lachlan feel itchy and desperate to let go.
Finally, after what felt like forever, Teagan's eyes slid away from him back to her nephew—though she kept her hold on his hand. He wondered if it was some sort of test.
"I take it you checked your email this morning?" she asked Vector.
The two werewolves walked off, Vector shooting him a confused look and a shrug over his shoulder before they disappeared into the house.
Lachlan stuck his hands in his pockets and tried not to feel completely out of place in the middle of a writhing werewolf pack, but it wasn't easy.
He could feel eyes on him but no one made any move to approach, which he counted a small mercy. It was hard enough figuring out where he stood with Vector when it was just the two of them, and they still hadn't discussed what they were going to do about the future—and Vector's work situation. If anyone here asked him what he was to the wolf, he didn't think he'd be able to give them a satisfactory answer. That uncertainty drove a little part of his brain to distraction.
But Lachlan had had other designs on attending than just seeing Vector: he had to talk to Patrick Clanahan. Even if it was gauche to go to the man's family gathering to get information on a case, it had been a week and Lachlan hadn't heard anything from Mallory despite her promise to keep him informed.
He'd already had to call Alan's grandmother back east and break the news to her, had to listen to her cry quietly into the receiver for the better part of half an hour before he'd been able to end the call. And he didn't have any more information than when the EMTs had called to let him know his best friend was dead.
What good was he as a private investigator if he couldn't get information on his own friend's death?
Well, he wasn't technically an investigator at all, but that was another matter.
It wasn't going to do him any good standing around here like a schmuck, he might as well take a look around and see if he could find Patrick Clanahan for himself.
He ducked his head and strolled back towards the house, eyes sweeping over the crowd of werewolves knotted around the grills and the picnic tables laden with chips, buns, paper plates, and disposable silverware. He caught the eye of a young woman sipping a beer and looked away. A quick glance back showed her still staring at him but she'd been joined by a familiar pair of broad shoulders in a white tank top and khaki shorts: bingo.
Lachlan cut around the throng, headed towards Patrick Clanahan and the woman. He was still trying to come up with something to say when the girl raised her hand and waved at him. Confused, Lachlan walked over. She was sitting on top of one of the weathered picnic tables, her feet propped up on the bench seat. Patrick Clanahan had sat down next to her sneakers and was bent over a book, the sunlight glaring off the page almost too painful to look at. This, however, did not seem to deter the werewolf whose eyes never left the page.
"Hi!" she greeted brightly, smile visibly growing as she patted the table next to her.
"What?" Patrick Clanahan snarled and turned his squint on Lachlan. "Oh." He shrugged.
"Are you in the FBI now too?" she asked with a confused expression.
His explanation seemed to confuse her anymore if the frown on her face was any indication, and Lachlan remembered how useless it probably was to try and bend the truth around werewolves who could literally hear and smell when he was lying. Still, it was his story and he might as well stick with it now that he'd spun it.
"That's cool," she said, nodding her head and raising her beer to him.
It took him a second to realize that she had done it as a toast. He clinked their bottles together and glanced at Patrick, but the other werewolf had already lost interest in their conversation. His head was bent back over the large tome in front of him. Lachlan thought it was odd that the werewolf had brought what looked like a history text to his family's holiday party.
"Work," Patrick grunted without nothing to look up.
Grace rolled her eyes again, kicking her feet against the edge of the picnic bench and making the entire seat shudder a little.
Lachlan's eyebrows edged up his forehead. He drained his beer, racking his brain for something he could say to draw Patrick Clanahan out of his book when it was clear he wasn't in much of a mood to talk to anyone, let alone his cousin's pet human.
"So, you and Vector, huh?" Grace asked with a wide grin and her eyebrows waggling at him.
"Ah, man, don't be like that. You can be honest with us," she said, digging her knee into her brother's side.
"Leave him alone," Patrick growled and stood up. He gave Grace a stern look before he grabbed his book and stomped back inside the house.
Lachlan shifted, uncomfortable at being witness to the tension between the two.
"I'm really happy that Vector's back. Happy for you both," she gave him a weak smile.
"Yeah. Um, will you excuse me?" He didn't wait for an answer, spun on his heals, and hurried in the direction Patrick had disappeared.
He followed his gut, winding through the chattering cooks in the kitchen, and found the beta tucked up in a study off the main hall. It might have been more accurate to call the room a library, rather than just a study, as it was decorated with plush rugs, ample seating, and floor to ceiling bookcases full of books. The lighting in the room had been left off, and the house's central air pumped in a cool, artificial breeze that made goosebumps ripple across his bare arms.
"What do you want?" a grim voice asked.
He jumped and caught Patrick Clanahan's glare.
"I'm working on it," the wolf said, gesturing angrily with the book in his lap.
Lachlan crossed the room to get a better look, surprised when he saw that the pages appeared to be covered in runes.
"But that doesn't explain why you're still looking into the St Mark's bodies!" Lachlan snapped, reaching out to grab the book in Patrick Clanahan's hands. The wolf moved faster—grabbing his wrist and shoving him away with a growl.
"Keep your hands to yourself," the wolf snapped, glaring at him.
"Ouch." Lachlan rubbed his wrist. The wolf was stronger than he'd expected. He wouldn't be surprised if he had a couple finger shaped bruises by the end of the day, and all it had taken was a second of contact.
"What story?" he asked petulantly, drawing back.
Patrick snorted, and shoved his shoulders into the back of the couch. "The one about doing 'consulting' work," he said, spitting out the words.
Lachlan gritted his teeth and brushed out of the room. It was clear he wasn't going to get anything from that angle.
Lachlan pasted a bland smile onto his face and slid his hand into his pocket. His guts squirmed with anger, but he wasn't willing to let Vector see just how upset he was.
"Sure." Lachlan let his ex-partner lead him back outside and tried to put thoughts of Alan out of his head for an hour.


To celebrate the new opening, Beyond Sushi will donate 50 percent of its first-day sales to Safe Haven Animal Sanctuary.
Beyond Sushi announced the opening of its sixth location on April 23 at 215 Mulberry Street.
With its SoHo location, Beyond Sushi is back to the quick-service scene after the success of their full-service restaurant serving an expanded dinner menu on W 37th street.
"Our approach is to have a fast-casual location with minimal seating where people can grab and go or dine in if they choose," Guy Vaknin says.
Priding itself in high-quality products and consistent service, Beyond Sushi attracts a loyal following of both vegan and non-vegan customers. 40 percent of its patrons do not follow a vegan diet and 60 percent of its clientele are repeat customers.
To celebrate the new opening, Beyond Sushi will donate 50 percent of its first-day sales to Safe Haven Animal Sanctuary, a nonprofit organization in Poughquag, NY that provides care and shelter for abused and neglected animals.
The idea of Beyond Sushi was conceived after Chef Guy Vaknin tested his creations at NYC Vegetarian Food Festival. The concept of vegan sushi quickly caught on after its first brick-and-mortar location opened in July 2012. The company now operates multiple locations and is one of the largest independent vegan brands in New York City. In May 2017, Beyond Sushi opened its first full-service location with a dinner menu focusing on shared plates in addition to its core offerings.


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Human Placental Trophoblasts Infected by Listeria monocytogenes Undergo a Pro-Inflammatory Switch Associated With Poor Pregnancy Outcomes.
ABSTRACT: The placenta controls the growth of the fetus and ensures its immune protection. Key to these functions, the syncytiotrophoblast (SYN) is a syncytium formed by fusion of underlying mononuclear trophoblasts. The SYN covers the placental surface and is bathed in maternal blood to mediate nutritional and waste exchanges between the mother and fetus. The bacterial pathogen Listeria monocytogenes breaches the trophoblast barrier and infects the placental/fetal unit resulting in poor pregnancy outcomes. In this work, we analyzed the L. monocytogenes intracellular lifecycle in primary human trophoblasts. In accordance with previous studies, we found that the SYN is 20-fold more resistant to infection compared to mononuclear trophoblasts, forming a protective barrier to infection at the maternal interface. We show for the first time that this is due to a significant reduction in L. monocytogenes uptake by the SYN rather than inhibition of the bacterial intracellular division or motility. We here report the first transcriptomic analysis of L. monocytogenes-infected trophoblasts (RNA sequencing). Pathway analysis showed that infection upregulated TLR2, NOD-like, and cytosolic DNA sensing pathways, as well as downstream pro-inflammatory circuitry (NF-κB, AP-1, IRF4, IRF7) leading to the production of mediators known to elicit the recruitment and activation of maternal leukocytes (IL8, IL6, TNFα, MIP-1). Signature genes associated with poor pregnancy outcomes were also upregulated upon infection. Measuring the release of 54 inflammatory mediators confirmed the transcriptomic data and revealed sustained production of tolerogenic factors (IL-27, IL-10, IL-1RA, TSLP) despite infection. Both the SYN and mononuclear trophoblasts produced cytokines, but surprisingly, some cytokines were predominantly produced by the SYN (IL-8, IL-6) or by non-fused trophoblasts (TNFα). Collectively, our data support that trophoblasts act as placental gatekeepers that limit and detect L. monocytogenes infection resulting in a pro-inflammatory response, which may contribute to the poor pregnancy outcomes if the pathogen persists.
Resveratrol inhibits release of soluble fms-like tyrosine kinase (sFlt-1) and soluble endoglin and improves vascular dysfunction - implications as a preeclampsia treatment.
Project description:Preeclampsia is a disease of pregnancy associated with placental oxidative stress, inflammation and elevated release of anti-angiogenic factors sFlt-1 and soluble endoglin. These placental factors cause generalized maternal endothelial dysfunction. There are no treatments to halt disease progression; delivery is the only cure. Resveratrol modulates pathways involved in inflammation and oxidative stress and may offer a potential therapeutic for preeclampsia. Resveratrol reduced sFlt-1, sFlt-1 e15a and soluble endoglin secretion from primary trophoblasts and HUVECs and reduced mRNA expression of pro-inflammatory molecules NFκB, IL-6 and IL-1β in trophoblasts. IL-6, IL-1β and TNFα secretion were also significantly reduced. In HUVECs, resveratrol significantly increased mRNA of anti-oxidant enzymes HO-1, NQO1, GCLC and TXN but did not significantly alter HO-1 protein expression, whilst reducing HO-1 protein in trophoblast. Endothelial dysfunction was induced in HUVECs using TNFα, increasing expression of cell adhesion molecule VCAM1 and adhesion of peripheral blood mononuclear cells, both of which were increased further by resveratrol. In contrast, resveratrol significantly reduced TNFα-induced Endothelin-1 (a vasoconstrictor) and significantly increased the phosphorylation of endothelial nitric oxide synthase (eNOS). In summary, resveratrol decreases secretion of anti-angiogenic factors however its effects on the endothelium are mixed. Overall, it may have potential as a treatment for preeclampsia.
Listeriosis in the pregnant guinea pig: a model of vertical transmission.
Project description:Feto-placental infections represent a major cause of pregnancy complications, and yet the underlying molecular and cellular mechanisms of vertical transmission are poorly understood. Listeria monocytogenes, a facultative intracellular pathogen, is one of a group of pathogens that are known to cause feto-placental infections in humans and other mammals. The purpose of this study was to evaluate possible mechanisms of vertical transmission of L. monocytogenes. Humans and guinea pigs have a hemochorial placenta, where a single layer of fetally derived trophoblasts separates maternal from fetal circulation. We characterized L. monocytogenes infection of the feto-placental unit in a pregnant guinea pig model and in primary human trophoblasts and trophoblast-derived cell lines. The clinical manifestations of listeriosis in the pregnant guinea pigs and the tropism of L. monocytogenes to the guinea pig placenta resembled those in humans. Trophoblast cell culture systems were permissive for listerial growth and cell-to-cell spread and revealed that L. monocytogenes deficient in internalin A, a virulence factor that mediates invasion of nonphagocytic cells, was 100-fold defective in invasion. However, crossing of the feto-placental barrier in the guinea pig model was independent of internalin A, suggesting a negligible role for internalin-mediated direct invasion of trophoblasts in vivo. Further understanding of vertical transmission of L. monocytogenes will help in designing more effective means of treatment and disease prevention.
| S-EPMC343973 | BioStudies
Inflammasome signaling in human placental trophoblasts regulates immune defense against Listeria monocytogenes infection.
Project description:The human placenta is a dynamic organ that modulates physiological adaptations to pregnancy. To define the immunological signature of the human placenta, we performed unbiased profiling of secreted immune factors from human chorionic villi isolated from placentas at mid and late stages of pregnancy. We show that placental trophoblasts constitutively secrete the inflammasome-associated cytokines IL-1β and IL-18, which is blocked by NLRP3 inflammasome inhibitors and occurs without detectable gasdermin D cleavage. We further show that placenta-derived IL-1β primes monocytes for inflammasome induction to protect against Listeria monocytogenes infection. Last, we show that the human placenta responds to L. monocytogenes infection through additional inflammasome activation and that inhibition of this pathway sensitizes villi to infection. Our results thus identify the inflammasome as an important mechanism by which the human placenta regulates systemic and local immunity during pregnancy to defend against L. monocytogenes infection.
InlP, a New Virulence Factor with Strong Placental Tropism.
Project description:Intrauterine infection is a major detriment for maternal-child health and occurs despite local mechanisms that protect the maternal-fetal interface from a wide variety of pathogens. The bacterial pathogen Listeria monocytogenes causes spontaneous abortion, stillbirth, and preterm labor in humans and serves as a model for placental pathogenesis. Given the unique immunological environment of the maternal-fetal interface, we hypothesized that virulence determinants with placental tropism are required for infection of this tissue. We performed a genomic screen in pregnant guinea pigs that led to the identification of 201 listerial genes important for infection of the placenta but not maternal liver. Among these genes was lmrg1778 (lmo2470), here named inlP, predicted to encode a secreted protein that belongs to the internalin family. InlP is conserved in virulent L. monocytogenes strains but absent in Listeria species that are nonpathogenic for humans. The intracellular life cycle of L. monocytogenes deficient in inlP (?inlP) was not impaired. In guinea pigs and mice, InlP increased the placental bacterial burden by a factor of 3 log10 while having only a minor role in other maternal organs. Furthermore, the ?inlP strain was attenuated in intracellular growth in primary human placental organ cultures and trophoblasts. InlP is a novel virulence factor for listeriosis with a strong tropism for the placenta. This virulence factor represents a tool for the development of new modalities to prevent and treat infection-related pregnancy complications.
Hofbauer Cells Spread Listeria monocytogenes among Placental Cells and Undergo Pro-Inflammatory Reprogramming while Retaining Production of Tolerogenic Factors.
Project description:Pregnant women are highly susceptible to infection by the bacterial pathogen Listeria monocytogenes, leading to miscarriage, premature birth, and neonatal infection. L. monocytogenes is thought to breach the placental barrier by infecting trophoblasts at the maternal/fetal interface. However, the fate of L. monocytogenes within chorionic villi and how infection reaches the fetus are unsettled. Hofbauer cells (HBCs) are fetal placental macrophages and the only leukocytes residing in healthy chorionic villi, forming a last immune barrier protecting fetal blood from infection. Little is known about the HBCs' antimicrobial responses to pathogens. Here, we studied L. monocytogenes interaction with human primary HBCs. Remarkably, despite their M2 anti-inflammatory phenotype at basal state, HBCs phagocytose and kill non-pathogenic bacteria like Listeria innocua and display low susceptibility to infection by L. monocytogenes. However, L. monocytogenes can exploit HBCs to spread to surrounding placental cells. Transcriptomic analyses by RNA sequencing revealed that HBCs undergo pro-inflammatory reprogramming upon L. monocytogenes infection, similarly to macrophages stimulated by the potent M1-polarizing agents lipopolysaccharide (LPS)/interferon gamma (IFN-γ). Infected HBCs also express pro-inflammatory chemokines known to promote placental infiltration by maternal leukocytes. However, HBCs maintain the expression of a collection of tolerogenic genes and secretion of tolerogenic cytokines, consistent with their tissue homeostatic role in prevention of fetal rejection. In conclusion, we propose a previously unrecognized model in which HBCs promote the spreading of L. monocytogenes among placental cells and transition to a pro-inflammatory state likely to favor innate immune responses, while maintaining the expression of tolerogenic factors known to prevent maternal anti-fetal adaptive immunity. IMPORTANCE Infection of the placental/fetal unit by the facultative intracellular pathogen Listeria monocytogenes results in severe pregnancy complications. Hofbauer cells (HBCs) are fetal macrophages that play homeostatic anti-inflammatory functions in healthy placentas. HBCs are located in chorionic villi between the two cell barriers that protect fetal blood from infection: trophoblast cells at the maternal interface (in contact with maternal blood), and fetal endothelial cells at the fetal interface (in contact with fetal blood). As the only leukocytes residing in chorionic villi, HBCs form a critical immune barrier protecting the fetus from infection. Here, we show that although HBCs display low susceptibility to L. monocytogenes, the bacterium still replicates intracellularly and can spread to other placental and fetal cells. We propose that HBCs are permissive to L. monocytogenes transplacental propagation and can repolarize toward a pro-inflammatory phenotype upon infection. However, consistent with their placental homeostatic functions, repolarized HBCs maintain the expression of tolerogenic factors known to prevent maternal anti-fetal adaptive immunity, at least at early stages of infection.
Decidual NK Cells Transfer Granulysin to Selectively Kill Bacteria in Trophoblasts.
Project description:Maternal decidual NK (dNK) cells promote placentation, but how they protect against placental infection while maintaining fetal tolerance is unclear. Here we show that human dNK cells highly express the antimicrobial peptide granulysin (GNLY) and selectively transfer it via nanotubes to extravillous trophoblasts to kill intracellular Listeria monocytogenes (Lm) without killing the trophoblast. Transfer of GNLY, but not other cell death-inducing cytotoxic granule proteins, strongly inhibits Lm in human placental cultures and in mouse and human trophoblast cell lines. Placental and fetal Lm loads are lower and pregnancy success is greatly improved in pregnant Lm-infected GNLY-transgenic mice than in wild-type mice that lack GNLY. This immune defense is not restricted to pregnancy; peripheral NK (pNK) cells also transfer GNLY to kill bacteria in macrophages and dendritic cells without killing the host cell. Nanotube transfer of GNLY allows dNK to protect against infection while leaving the maternal-fetal barrier intact.
Pathogens and the placental fortress.
Project description:Placental infections are major causes of maternal and fetal disease. This review introduces a new paradigm for placental infections based on current knowledge of placental defenses and how this barrier can be breached. Transmission of pathogens from mother to fetus can occur at two sites of direct contact between maternal cells and specialized fetal cells (trophoblasts) in the human placenta: firstly, maternal immune and endothelial cells juxtaposed to extravillous trophoblasts in the uterine implantation site and secondly, maternal blood surrounding the syncytiotrophoblast (SYN). Recent findings suggest that the primary vulnerability is in the implantation site. We explore evidence that the placental SYN evolved as a defense against pathogens, and that inflammation-mediated spontaneous abortion may benefit mother and pathogen.
Immunomodulator expression in trophoblasts from the feline immunodeficiency virus (FIV)-infected cat.
Project description:FIV infection frequently compromises pregnancy under experimental conditions and is accompanied by aberrant expression of some placental cytokines. Trophoblasts produce numerous immunomodulators that play a role in placental development and pregnancy maintenance. We hypothesized that FIV infection may cause dysregulation of trophoblast immunomodulator expression, and aberrant expression of these molecules may potentiate inflammation and compromise pregnancy. The purpose of this project was to evaluate the expression of representative pro-(TNF-?, IFN-?, IL-1?, IL-2, IL-6, IL-12p35, IL-12p40, IL-18, and GM-CSF) and anti-inflammatory cytokines (IL-4, IL-5, and IL-10); CD134, a secondary co-stimulatory molecule expressed on activated T cells (FIV primary receptor); the chemokine receptor CXCR4 (FIV co-receptor); SDF-1?, the chemokine ligand to CXCR4; and FIV gag in trophoblasts from early-and late-term pregnancy.We used an anti-cytokeratin antibody in immunohistochemistry to identify trophoblasts selectively, collected these cells using laser capture microdissection, and extracted total RNA from the captured cell populations. Real time, reverse transcription-PCR was used to quantify gene expression.We detected IL-4, IL-5, IL-6, IL-1?, IL-12p35, IL-12p40, and CXCR4 in trophoblasts from early-and late-term pregnancy. Expression of cytokines increased from early to late pregnancy in normal tissues. A clear, pro-inflammatory microenvironment was not evident in trophoblasts from FIV-infected queens at either stage of pregnancy. Reproductive failure was accompanied by down-regulation of both pro-and anti-inflammatory cytokines. CD134 was not detected in trophoblasts, and FIV gag was detected in only one of ten trophoblast specimens collected from FIV-infected queens.Feline trophoblasts express an array of pro-and anti-inflammatory immunomodulators whose expression increases from early to late pregnancy in normal tissues. Non-viable pregnancies were associated with decreased expression of immunomodulators which regulate trophoblast invasion in other species. The detection of FIV RNA in trophoblasts was rare, suggesting that the high rate of reproductive failure in FIV-infected queens was not a direct result of viral replication in trophoblasts. The influence of placental immune cells on trophoblast function and pregnancy maintenance in the FIV-infected cat requires additional study.
Invasive extravillous trophoblasts restrict intracellular growth and spread of Listeria monocytogenes.
Project description:Listeria monocytogenes is a facultative intracellular bacterial pathogen that can infect the placenta, a chimeric organ made of maternal and fetal cells. Extravillous trophoblasts (EVT) are specialized fetal cells that invade the uterine implantation site, where they come into direct contact with maternal cells. We have shown previously that EVT are the preferred site of initial placental infection. In this report, we infected primary human EVT with L. monocytogenes. EVT eliminated ?80% of intracellular bacteria over 24-hours. Bacteria were unable to escape into the cytoplasm and remained confined to vacuolar compartments that became acidified and co-localized with LAMP1, consistent with bacterial degradation in lysosomes. In human placental organ cultures bacterial vacuolar escape rates differed between specific trophoblast subpopulations. The most invasive EVT-those that would be in direct contact with maternal cells in vivo-had lower escape rates than trophoblasts that were surrounded by fetal cells and tissues. Our results suggest that EVT present a bottleneck in the spread of L. monocytogenes from mother to fetus by inhibiting vacuolar escape, and thus intracellular bacterial growth. However, if L. monocytogenes is able to spread beyond EVT it can find a more hospitable environment. Our results elucidate a novel aspect of the maternal-fetal barrier.
Zika virus impacts extracellular vesicle composition and cellular gene expression in macaque early gestation trophoblasts
Project description:Zika virus (ZIKV) infection at the maternal-placental interface is associated with adverse pregnancy outcomes including fetal demise and pregnancy loss. To determine how infection impacts placental trophoblasts, we utilized rhesus macaque trophoblast stem cells (TSC) that can be differentiated into early gestation syncytiotrophoblasts (ST) and extravillous trophoblasts (EVT). TSCs and STs, but not EVTs, were highly permissive to productive infection with ZIKV strain DAK AR 41524. The impact of ZIKV on the cellular transcriptome showed that infection of TSCs and STs increased expression of immune related genes, including those involved in type I and type III interferon responses. ZIKV exposure altered extracellular vesicle (EV) protein, mRNA, and miRNA cargo, regardless of productive infection. These findings suggest that early gestation macaque TSCs and STs are permissive to ZIKV infection, and that EV analysis may provide a foundation for identifying non-invasive biomarkers of placental infection in a highly translational model.
2022-05-20 | PXD033289 | Pride


At least since the Renaissance, many artists and architects have proportioned their works to approximate the golden ratio—especially in the form of the golden rectangle, in which the ratio of the longer side to the shorter is the golden ratio—believing this proportion to be aesthetically pleasing. Mathematicians have studied the golden ratio because of its unique and interesting properties.
I find it very soothing. It gets me to sleep right away.


Ducks: At Ruff Row we love our ducks, we use them for herding and love baking with their eggs. We have two breeds Khaki Campbells and Ancona Ducks. Khakis are laying machines and better to work the dogs on as they are lighter weight, the Ancona's are a pretty heritage breed and good multi-purpose duck. In the future we'd like to raise pied campbells either by acquiring some white campbells and breeding them with the Khakis and may also try crossing the Ancona's with them.
We admired the Ancona ducks for years and finally acquired our first ducklings in June 2013. Since they are a Heritage breed in critical status they are not common birds. These birds came from two different sources and are the foundation of our breeding flock. We have birds in all three base colors, black, brown and blue.
We enjoy the Ancona ducks immensely. They are hardy, easy maintenance birds, and have laid for the most part through the winter. Their eggs weigh in at approximately 2.5 to 2.8 oz so are extra extra large egg.
Breed description from The Livestock Conservancy: "The Ancona averages 6 to 6.5 pounds and is a bit stockier than its close relative, the Magpie duck. It has a medium sized oval head, a medium-length bill that is slightly concave along the top line, an average neck that arches forward slightly and body carriage is 20 to 30 degrees above horizontal. The broken, mottled plumage is unique among ducks for, like Holstein cattle, there is no set design. "Any combination of white and color is acceptable as long as there are obvious broken areas on the head, backs, sides, and underbody." The neck is normally solid white, bills are yellow with dark green or black spotting, and the legs and feet are orange with black or brown markings that increase with age."
They are easy to handle birds and don't fly which makes them easy to keep penned. We use them for herding practice and their steady temperament is definitely an asset in that venue.
Please see our DUCK FACTS page for more information about duck keeping.
In 2015 we should have hatching eggs, ducklings (from time to time) and the occasional mature bird available. If you're interested in eggs, ducklings or ducks, please contact us so that we can notify you when we have stock available. Also please see our Ducks for Sale page for stock available.
Khaki Campbells: These birds are known for their egg laying-and lay eggs they do. I truly believe they'll give any chicken a run for its money, laying an average of 320 eggs a year. Campbell ducks are smaller than the anconas weighing in at 3-5 pounds. They come in khaki, dark and white (though the latter two color varieties are somewhat rare in the US). My campbells hatched out in March started laying in August.


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Journal of University Teaching & Learning Practice
Home > Senior DVC and DVC (Education) > JUTLP > Vol. 16 (2019) > Iss. 2
Individual Networks of Practice for PhD Research Socialisation
Richard Watson Todd, King Mongkut's University of Technology ThonburiFollow
Stephen Louw, King Mongkut's University of Technology ThonburiFollow
A PhD combines experiential learning of the research process with socialisation into the research community. Studying a PhD is a highly individual experience with each student seeking and receiving different types of support from different agents. In this paper we investigate the experiences of four PhD students at a Humanities faculty at a Thai university through a series of interviews. To account for the unique nature of each student's experience, we use Individual Networks of Practice (INoPs) as the main method of analysis. The interviews were first analysed by adapting Sala-Bubaré and Castelló's (2016) model of socialisation, identifying the social agents and the content of the experience shared with each agent, and then constructing an INoP (Zappa-Hollman and Duff 2015) map to visually represent each student's social network. These INoPs served to guide a qualitative analysis of the salient issues in the interviews. The INoPs highlight the unique nature of each student's set of agents and experiences, but there are also commonalities across students showing that peers and faculty staff serve as key social agents.
Watson Todd, Richard and Louw, Stephen, Individual Networks of Practice for PhD Research Socialisation, Journal of University Teaching & Learning Practice, 16(2), 2019.
Available at:https://ro.uow.edu.au/jutlp/vol16/iss2/14
Innovations and challenges in the teaching of statistics to non-specialists
Advancing Non-placement Work-integrated Learning Across the Degree
Becoming Well Read: Charting the complexities of academic reading and navigating the reading journeys of undergraduate and postgraduate students
Technology-enhanced academic language support (TALS)
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If your dream is to buy a home, having great credit is typically something you should work toward. However, while most lenders will look at your credit as one of the main factors in approving or denying your loan, some lenders offer no credit financing. If you don't have credit or have poor credit, this may be your best option for getting into a home. However, while you don't have to show your credit report, there are still strict lending requirements.
When choosing a real estate agent to help you sell your home, there is quite a number of things to consider: experience, knowledge of the industry and locale, contacts and network and reputation. Add to that list, personality. It is difficult to expect a reserved real estate agent to exude exuberance when showing a house. The very things that would have convinced you to buy the house may be understated by the realtor, causing you overlook a potentially lucrative investment.
If you want to avoid paying a real estate commission when selling your house, you could do so if you can find a buyer yourself. To do this, you could list your home for sale by owner. While this can help you save money on the commission, you will face a lot of challenges that you would not have if you hired a real estate agent for help. One challenge you may face is dealing with unqualified buyers.
Purchasing A New Home? What Should You Know About Potential Air Conditioner Problems?
If you're about to put an offer in on your next home, you may be excited at the prospect of finishing the inspection, appraisal, offer process, and finally closing on your new home. However, few things can dampen the new homeowner glow like unexpected problems with your air conditioning unit, and shelling out a few thousand dollars for repair or replacement while you're already juggling closing costs, moving costs, and other expenses can be quite a blow.


Rossi, F., Rosli, A. and Yip, N.
Researchers have argued that management academics' engagement with non-academic stakeholders involves knowledge co-production rather than simple knowledge transfer from the former to the latter. This study suggests that the conceptual lens of knowledge co-production not only more fittingly describes academic engagement but also enables a clearer understanding of how academic engagement produces impact beyond academia. Building upon qualitative evidence on collaborations between management academics and businesses in the United Kingdom, the study supports the characterisation of academic engagement as knowledge co-production and argues that its impact (i) strongly depends on sustained knowledge co-producing interactions, (ii) 'ripples out' serendipitously, indirectly benefiting many stakeholders in ways that often cannot be anticipated, and (iii) unfolds and persists over a long period. These findings have implications for impact assessment and the development of the impact research agenda.


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Hikk Naal is a Punjabi film starring Amrinder Gill, sam sohi (making his acting debut), Mahie Gill, Rana Ranbir & Binnu Dhillon.

Music for the film will be given by Tru-Skool and shooting of the movie starts August onwards in Canada.

Cast
 Amrinder Gill as Amar
 sam sohi as Jagjit Nri
 Mahie Gill as Rani
 Rana Ranbir as Sehaj
 Rahul Dev as Gurmit
 Kaamjeet Anmol as Angad
 B.N. Sharma as Raj
 Binnu Dhillon as Kinder
 Inderpreet Ghag as Happy
 Arshdeep singh as Amli
 Harman aulakh as Bhuru

Soundtrack

References

 Hikk Naal Punjabi Movie  on FilmsPunjabi.Com

Punjabi-language Indian films
2010s Punjabi-language films
2017 films

redpajama_set_name: RedPajamaWikipedia


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Pirates of the Caribbean in Order to Watch
Pirates of the Caribbean movie series is a highly popular franchise, the first movie of which was released in 2003. There is also a drive at the Disneyland Park of the same name, and apart from this, there are comics, books, and many video games.
At the time of release, the movies were at the Disney studios considered to be taboo because of the flop history of the movies. Even though the Pirates of the Caribbean was a gamble by Walt Disney, it did give a huge payoff with over $4.5 billion globally.
Considering the above, and also the popularity of the movie, today many people want to watch Pirates of the Caribbean in order. If you are also one of those people then give a read further to know more.
Pirates of the Caribbean in Order: Watch Order
Pirates of the Caribbean: Tales of the Code- Wedlocked (2011) – Short Movie
1. Pirates of the Caribbean: The Curse of the Black Pearl (2003)
2. Pirates of the Caribbean: Dead Man's Chest (2006)
3. Pirates of the Caribbean: At World's End (2007)
4. Pirates of the Caribbean: On Stranger Tides (2011)
5. Pirates of the Caribbean: Dead Men Tell No Tales (2017)
Pirates of the Caribbean: Order of Release
How many Pirates of the Caribbean movies are there?
Where to watch pirates of the Caribbean in order?
When is the Pirates of the Caribbean set?
Pirates of the Caribbean Watch Order
There are, as of now, 5 pirates of the Caribbean movies. Disney also announced the 6th movie, which will be released soon by the franchise. However, it is a spin-off movie with Captain Jack Sparrow along with Margot Robbie as the main character. To get information about the 1st 5 movies, the below-mentioned will provide details about them.
The first in Pirates of the Caribbean movie order, this movie directed by James Ward Byrkit is for the super fans. The movie shows Wenches Scarlett and Giselle for the wedding fixing each other wherein they were about to marry the groom. It was then they realized that both of their grooms were the same one, Jack Sparrow, and this is where 2 wenches went to the auction.
The film is short and the prequel to- The Curse of the Black Pearl, and it explains why the boat of Jack Sparrow, the Jolly Mon, was sinking at the story beginning. It also explains why wenches were upset at him, and it also implied how exactly cotton lost his one and only tongue.
This plot is an inspiration from the original Disney Park attraction auction scene. Even this project was in just a few days prepped well and just shot within 3 days. This short film has been based on the codebook of Pirate, as this was the device that could have easily tied later into the other stories too.
Also Read: All Madea Movies In Order
There are many Caribbean legends who speak about the Black Pearl, the pirate ship. Some even claim that it is nothing but the mere apparition that has been created in the heads of the sailors who get stunned by the rum.
But it was later that the black Captain Barbossa (infamous) to this teeth-armed ship, he one night attacked the palace of the British Governor Swann and then kidnapped Elizabeth, his one and only daughter.
Elizabeth has been promised to the other one, and this is why Will Turner, the young blacksmith decided to go in search of the phantom ship. He wanted to save that beautiful girl who he loved with all of his heart.
He was also helped by one of the unusual Captains named Jack Sparrow, who is one of the old pirates' stories, the main character. This Captain, however, was the irresistible adventurer with the solution for every single trouble. So, who would not like to sail out?
This is the second movie in the Pirates of the Caribbean movie order. While the prep for the wedding goes on, Elizabeth Swann and Will Turner get arrested by the orders of Lord Cutler Beckett.
They also got sentenced to death. Well, the condemnation herein has the goal, and that was that he wished to get hold of the magic compass of Jack Sparrow. It is for this compass and Sparrow, he gave the couple a pardon for the death penalty, but only if they were able to find it.
Well, none would want death, and neither did Will and therefore he agreed for the same and found Jack along with his crew on the wild island, trapped and captured by the Cannibals.
It was then he offered jack his help in rescuing, but he needed the magic compass in exchange. The best was that he agreed but put forward a condition that Will would help him find the Dead Man's Chest key, wherein there was the heart of terrible Captain Dutchman named Davy Jones, the crew of whom consisted of the dead sailors' souls. Also, in that haunted ship crew, there was also the father of Will, who was the former pirate.
Surely, Captain Davy Jones was a very powerful opponent, but he for sure had the terrible ally (the giant octopus named Kraken) at sea. Well, this is how these movies amidst the Pirates of the Caribbean order showed the beginning of the new deadly adventure, which started with Jack Turner, Elizabeth, and Will.
East India Company, Lord Cutler Beckett, gained control of a terrifying ghost ship along with the captain of the ship named Davy Jones. The Dutchman was roaming around seven seas, completely unstoppable and ruthlessly causing destruction of the pirate ships. It was all being done under Admiral Norrington's command.
Will, Elizabeth, and Captain Barbossa embarked on the desperate venture to bring together 9 pirate rulers who were the only hope for the defeat of Beckett. However, 1 of these pirate rulers was missing as Captain Jack Sparrow, one of the worst ever pirates, he was trapped in the closet of Davy Jones.
It was the dimension wherein the souls of the dead on the end of the high seas were. All thanks for it can be given to the encounter they all had with the monstrous Kraken.
Being members of the loose alliance, the gang was required to go to the dangerous as well as exotic Singapore. They were to face therein the Chinese pirate Captain named Sao Feng for getting the tickets and the ships which will help them to go the world's end for saving Jack.
Also Read: Twilight Movies Watch Order
In London, Captain Jack came across the woman from the past. He, however, isn't sure if she is a lover or the ruthless deceiver using him for information about the Source of Youth location. She also persuaded him to board Ship- Revenge of Queen Anne (captain is terrible Blackbeard and history's cruelest pirate). This is how Jack got into the unexpected adventure wherein he has no clue who to fear more, the woman or the Blackbeard.
Captain Salazar and his ghost sailors group, Jack Sparrow's old enemy, escaped from the Devil's Triangle (quite infamous), and they are now determined to kill the pirates from all around the world sea.
In order to prevent this, Jack Sparrow was required to find Poseidon's trident, the legendary magical object which can provide him with absolute control all over the sea. If you are watching Pirates of the Caribbean movies in order then you would not want to miss out on this one.
All the movies in Pirates of the Caribbean movie order were the diamond amidst years of failed attempts for launching on the big screen, the pirate properties. The film soon got popularity because of the skillful blend of the action of the sea and the humor running alongside the stellar cast of some top names.
The first movie of it made its debut in 2003, and since then, many movies get released talking of the story of the beloved Jack Sparrow and all his adventures that got against all of the other pirates, law, and also the supernatural beings.
So, if you are planning to watch through the pirates of the Caribbean in order of release, well, look for the list that has been provided below and have a great watch.
As of now, there are only 5 Pirates of the Caribbean movies in order, and the 6th one is expected to hit the cinema soon enough. The first release was made with the launching of Johnny Depp within the megastardom in the year 2003.
Since then, the movies have been sailing in order and entertaining the fans with the story of the ongoing trilogy. Some fans even say that watching the movies, one might be left all exhausted just like in the case of the theme park rides (from where the movie got the inspiration from), but for sure one will have a great time watching it and will take a long time to get over the same. So, why wait when such a great trilogy awaits your weekend?
There are a lot of places wherein one can watch the Pirates of the Caribbean in order. Get the Hotstar subscription or watch it on YouTube; the quality of the movies is just the way you might be looking forward to. One can even watch the movie on Google Play Movies & TV.
Talking about Netflix, as of now, only The Pirates of the Caribbean: Dead Men Tell No Tales, only this movie is available for streaming on Netflix. For the rest, one does have other ways to watch and complete the series.
One can also get these movies through ESPN+ and Hulu, the subscription of which, if purchased, will also allow one to watch the other movies and shows. So, by all means, it will be worth it to get the same and use it to watch some amazing shows.
Note that DVD and Blu-Ray are also available for the fans at a very reasonable price.
According to the screenwriter, the Pirates of the Caribbean story has been placed in the 30 year time period that has been set loosely in between 1720-1750. According to the writers, they by no means intend all of the movies to be entirely historically accurate.
Also Read: Underworld Movies In Chronological Order to Watch
The pirates of the Caribbean movie order might have started just like the attraction of Disneyland, but it has now grown to be quite a profitable production. It has been a long time since the 1st movie was released, and it showed the complicated situation in a very least expected way, but for sure, the characters like Johnny Depp, Orlando Bloom, Keira Knightley, all of them nailed the paradigm of the stories of the pirates.
With the replacement of the scenes full of violence and sex with the humor and the endless adventure, the fans for sure got a delightful experience. So, if you haven't watched the series yet, go on for sure and do not miss on to any movie. Also, wait for another installment which is surely going to be released soon.


Another site successfully fitted for Poundstretcher this week in Derry, another great job completed by the JMF team. From concept to installation this job was manufactured and fitted in under a week. We'd like to thank all the team at JMF and Poundstretcher for helping getting this massive installation victoriously built and finished. We are pleased to be adding this to our collection of site re-fits, including stores in Swansea, Penzance, Bitterne, Sittingbourne, Ramsey, Chatteris, Swaffham, Syston, Warrington and Telford. Once again a big thank you to everyone!!!


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Bella Hadid, Kendall Jenner, and More Play in Dior's Masked Magic Garden
Christian Dior, the couturier, was an avid gardener. He was also a man of many superstitions and just as many lucky talismans. He loved a good masked ball.
On Monday night, Dior, the house, reunited all those themes at the Musée Rodin, projecting stars, zodiac signs, and mysterious landscapes onto the museum's fa?ade; populating the candlelit garden with unicorns; and transforming the show venue into a lavish garden partyA party is a gathering of people who have been invited by a host for the purposes of socializing, conversation, recreation, or as part of a festival or other commemoration of a special occasion. that will probably go down as one of the most extravagant fetes Paris has ever seen.
For the 200 or so early arrivals who may have forgotten theirs, masks by Stephen Jones awaited on silver trays; around a hedgerow, a gold-turbaned tarot reader held court and, toward the back of the room, banquet tables were laden with so many treats it looked like a scene out of Jean Cocteau's Beauty and the Beast.
Most took the dress code—black tie and ball masks—gleefully to heart. Among the guests spotted socializing under the arbors were Dior artistic directors Maria Grazia Chiuri (womenswear) and Kris Van Assche (men's), Kendall Jenner, Bella Hadid, A$AP Rocky, Eva Herzigova, Blanca Li, Peter Marino, Giambattista Valli, Elie Top, and a slew of models. Even Bernard Arnault and his wife, Hélène Mercier-Arnault,, donned masks and passed discreetly through the crowd.
"Honestly, I've had no time to read any reviews. I hope people like it," said Chiuri, laughing. "We worked hard, and now it's time to play and have a good time!"
"This is just absolutely glamorous," noted Li. "I love the mask because it gives you the sensation that no one recognizes you; it's nice. People are relaxed and having fun, which is not always how things are in Paris. Tonight we're really in a magic place and we're here to party."
"It reminds me of Barry Lyndon, actually," offered Marisa Berenson. "It's quite extraordinary, and you don't often see that these days. It brings back the magic."
http://www.vogue.com/13524854/bella-hadid-kendall-jenner-asap-rocky-christian-dior-couture-paris-after-party/
Dior offers pure escapism with fairytale haute couture show
Maria Grazia Chiuri made headlines three months ago with a Christian Dior debut which featured T-shirts proclaiming "We should all be feminists". Three months later, those prescient T-shirts have been seen on Natalie Portman and Rihanna at the women's marches this weekend, and their imminent arrival in store was a hot topic of front row conversation at the creative director's first haute couture collection for the house.
However, Chiuri's take on the zeitgeist has moved on, so that rather than protest T-shirts, she offered pure escapism. Having negotiated the security checks which are now a familiar feature of Paris catwalk shows, the ultra high-rolling shoppers traversing the gardens of the Musée Rodin where the show was staged were confronted with a full-sized maze constructed from hedges, prettily strewn with out-of-season berries.
Beyond this, they entered a mirrored cube the size of a modest chateau, inside which a catwalk carpeted with thick, fragrant moss wound its way around a wishing tree hung with lightbulbs, crystals, fob watches and gems on strands of silk ribbon. Several hundred green velvet cushions lined the edge of the catwalk for guests to sit on. "It is impossible to use the same language in haute couture as in prêt-à-porter," Chiuri said backstage after the show. "Prêt-à-porter is about a moment in time, but couture must be timeless."
The fairytale mood was a tonal shift from her Dior debut but a familiar aesthetic from the designer's years at Valentino. But while the lean, loose silhouette, the romantic tendrils of hair and the astronomical and magical imagery drew on the aesthetic she created there – best characterised as "Renaissance princess who shops at Net-a-Porter" – there was a newly bold, modern attitude which spoke of a designer on a mission to shake up the house of Dior, which celebrates its 70th anniversary this year.
In contrast to the restrained, private presence of her predecessor, Raf Simons, Dior's first female couturier wears her heart on her sleeve. Having made a political statement with her first collection, she made a personal statement with her second, dedicating the show to Franca Sozzani, the editor-in-chief of Italian Vogue who died last month. She also showed a willingness to acknowledge vulnerability unusual in the smoke-and-mirrors pomp of haute couture, where image is guarded at all costs. The labyrinth represented the challenge of working with the Dior ateliers, she said, "which are so huge, and very different from what I knew in Italy. And I don't speak French. I know I will find a way, but really, it's a trip".
Following the customary format of haute couture, the show began with a simple, monochrome tailoring section before building to a crescendo of fantastical eveningwear. In popular culture, the best known Dior silhouette is still the New Look's full-skirted dress. But Chiuri is foregrounding a different Dior icon, in the bar jacket, with its proud moulded hips. Bar jackets, sometimes with caped shoulders, were prominent in the first section, often worn with what at first glance appeared to be skirts but were in fact wide culottes. "I wanted the clothes to be dreamy, but also modern and wearable," said Chiuri.
There were flights of untrammelled fancy in the Primavera-style goddess gowns, silk flowers pressed flat between layers of pale tulle. But tiaras made of feathers and black net dragonfly masks struck a sharply surreal note, and there was dramatic eveningwear in bold, architectural shapes which seemed a logical extension of how the new Dior brand might look on the red carpet. A navy velvet dress with a stark, simple V-neck bodice and panels of sunray-pleated black chiffon in the skirtA skirt is a tube- or cone-shaped garment that hangs from the waist or hips and covers all or part of the legs. The hemline of skirts can vary from micro to floor-length and can vary according to cultural conceptions of modesty and aesthetics as well as the wearer's personal taste, which can be influenced by such factors as fashion and social context. Most skirts are self-standing garments, but some skirt-looking panels may be part of another garment such as leggings, shorts, and swimsuits., and an off-white column dress with flounced sleeves were both grander relations of looks which are recognisably part of a modern woman's real wardrobe.
https://www.theguardian.com/fashion/2017/jan/23/dior-offers-pure-escapism-with-fairytale-haute-couture-show


Now availables in the iTunes podcast store! This week the 3 siblings introduce a new game called "Buy, Rent or Meh," forcing us to rank movies we love and movies we don't love. They also discuss getting sick on vacation, Jem and the Holograms, the Great British Baking show, Disney Pixar's Coco, the Good Place and where to find chicken fingers in Berkley.


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Authorities say that a cop may face charges after video showed him smash a handcuffed man's face into the concrete for no reason.
Silver Spring, MD — A video shared with the Free Thought Project this week shows officers with the Montgomery County Police department holding down a handcuffed man as one of them snaps and drops a knee to the back of his head, smashing his face into the concrete. After the video began to go viral on Twitter, investigators say the officer involved now faces potential criminal charges.
Montgomery County Police said on Friday that the officer seen dropping a knee to the head of the incapacitated and restrained individual could face charges for excessive force. This is the same department whose officer was filmed last month using the N-word while harassing citizens.
As Patch reports:
Just last month, Montgomery County Executive Marc Elrich and Council member Will Jawando hosted a community forum on policing. That came on the heels of a police transparency bill signing, and amid a police investigation into a video that purportedly shows a white officer using a racial slur while talking to a group of black men.
The latest controversial encounter took place at a McDonald's at the Aspen Hill Shopping Center in Silver Spring. While it's not clear when the arrest took place, videos of the profanity-laced exchange surfaced on social media on July 4.
After the video began to go viral, the department released a statement claiming that the incident was under investigation and they asked for anyone with information about the incident to contact them.
"The Montgomery County Department of Police takes any complaints or evidence of excessive force seriously," officials tweeted. "An investigation into this matter has been opened and will be investigated thoroughly."
Below is the original video from Twitter, warning it contains graphic content.
Aye y'all get this viral for me my bro peso got slam for no reason fuck y'all MOCO police I swear y'all niggas pussy y'all wanna treat us like dogs we gonna treat y'all like dogs we gonna show y'all how we do police @mcpnews pic.twitter.com/rTixtw0wOf
— PLU$XANZ (@PLUSXANZ) July 4, 2019
"It's hard to imagine what circumstances would prompt the officer to use that level of force with a suspect who is already on the ground and restrained," said Councilman Jawando on Twitter.
Acting Police Chief Marcus Jones has asked the State's Attorney to investigate if charges against the officer are appropriate, according to Patch.
When asked, the MCPD responded, noting that there could indeed be charges in both cases.
"There may be criminal charges out of this," Capt. Thomas Jordan, a police spokesman, told Montgomery Community Media on Friday. "Our preliminary review does not seem to support [the officer] using the N-word," Jordan said.
As if a white police officer using the N-word when harassing a group of black people would ever be supported.
After the brief video went viral, another video surfaced the following day showing the moments before the man was handcuffed. As the video shows, the man is certainly struggling, but he has a half dozen cops on top of him.
Once he is subdued and cuffed outside there was no need for anymore force, but that didn't stop the officer from dropping his knee.
NEW: Yesterday video surfaced on Twitter showing an altercation between MoCo Police and a male suspect at the McDonald's in Aspen Hill, Md. In it, a male officer is seen driving his knee into the suspect's head.
I just obtained this clip, showing more of what led to that moment. pic.twitter.com/fRptFXsLQD
— Kevin Lewis (@ABC7Kevin) July 4, 2019
Police will also review the arrest from the body cam footage of the officer, Jordan said.
"I want to ensure that all residents of this county are treated respectfully and fairly by our police force," Elrich said on Twitter after the video surfaced.
According to Patch, Montgomery County Council President Nancy Navarro and Vice President Sidney Katz issued a statement after viewing cell phone videos from community members showing the use of force during the arrest at McDonald's.
"We are outraged and deeply saddened to watch the videos that show a young man being apprehended by Montgomery County Police officers using what appears to be excessive force. We appreciate that Acting Police Chief Marcus Jones has promptly initiated a thorough investigation into this arrest," the statement said. "The council is committed to making sure that all our residents feel safe when interacting with police officers. We have asked that Chief Jones appear before the Montgomery County Council as soon as possible in July to brief us on this incident and share with us his strategies for community-police relations, including de-escalation training strategies, to make our county a safe place for all our residents."


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Massive Vote Buying, Electoral Offences Marr Edo Election, Says CDD
After several weeks of electioneering and assurances from the Independent National Electoral Commission (INEC), the Edo State Governorship election has been described as one marred by massive vote-buying and several electoral offences.
These formed part of an interim report of the Centre for Democracy and Development (CDD), a non-governmental organization working on democratic governance, human rights and criminal justice reform.
The election is widely seen as a test for Nigeria's electoral body, as citizens of the state vote their next governor, but it has been hit by the biggest logistic challenge in the middle of a pandemic.
CDD's Director, Idayat Hassan, while delivering the report expressed concern that "despite expending time and resources to deploy thousands of law enforcement officials to the electoral space, the officers did nothing in the face of infractions such as vote buying."
According to Hassan, the two major political parties were accomplices in vote-buying and selling using new tactics.
"Politicians, in an attempt to circumvent the electoral process, used young girls as their contact with the voters for the trading. We had the issuing of a ticket as receipts to get their N5,000 and snapping of pictures. There are structured approaches to vote-buying in this election and the two major parties are complicit," she said.
The CDD boss faulted INEC over late arrival of their officials and materials, which delayed the commencement of elections in several polling units.
"This is occasioned by poor logistics management," she added.
She noted also that the late arrival of INEC officials led to the lax compliance to Covid-19 protocol, particularly social distancing.
"Due to the late arrival of INEC officials in the polling units, and in a bid to immediately commence the elections, some of these processes had to be jettisoned," she said.
CDD said another factor that marred the election was the issue of faulty card readers and non-payment of allowances to ad-hoc staff. Hassan said there were several electoral offences recorded, such as campaigning during voting, and attempts by other people to use voters' card that belong to someone else.
Meanwhile, Auwal Musa, the Executive Director, Civil Society Legislative Advocacy Centre (CISLAC), said there was an urgent need for government to initiate electoral reforms so as to restore the credibility of the electoral body (INEC).
He expressed hope that the Edo elections will propel the federal government to embark on electoral reforms.
"There is no way you can have credible elections if you refuse to create electoral reforms to deal with so many deficits in our electoral system and practice.
"As we go into Ondo Governorship election, we should commence the process of electoral reforms to protect votes and guarantee the integrity of the electoral system," he said.


This was inspired by my Ayatul Kursi lesson, which I wrote for my older kids. This one's for the younger ones and its centered around just one of the concepts that are mentioned in Ayatul Kursi, the Name of Allah: Al Hayyul Qayyum.
Its reported in Tafsir Ibn Kathir that the Prophet (salla Allahu alayhi wa sallam) said that this is the greatest Name of Allah. The lesson focuses on learning its meaning as well as encouraging kids to use this Name when making supplications as the Prophet (salla Allahu alayhi wa sallam) said to supplicate Allah with this Name and it would be answered (also found in the Tafsir).
( I was just on the page, and was able to download the file, but returned and the old new page is showing up. When you visit the main page, you should see an entry for 7/19. If you don't, that's the old page, and in that case the file might show up as missing. Not sure why this happened, but please try back again a little later and it may fix itself or what not).


Responsible for all legal and regulatory issues, including the Florida Board of Medicine, the Florida Department of Health and the Agency for Health Care Administration. Also, please contact Chris for any issues concerning managed care or other reimbursement issues.
Responsible for all legislative activities relating to the FSDDS.


Here's a good op-ed, published in the Guardian/Observer. On the eve of the his party's conference, a Conservative MP calls for a new vision to recapture support across all ages.
Whilst there's nothing fundamentally wrong with this article, it's far too weak in my view. With Boris Johnson about to make a leadership bid, the Conservative Party is once again dominated by 'traditional conservatives', and the radical reformers are in the wilderness. So far, the Cameron/May years have been squandered, with the rich and privileged going from strength to strength.
I've always been a one-nation conservative in the Disraeli tradition but my left-wing friends tell me that one-nation tories are rare beasts these days.
Personally, I can't see the Conservative Party appealing to younger voters in the next election. But the first step is surely a new leader, with the appeal to win the younger vote?


Starting on January 1st 2015 Steven Abraham commenced an attempt to beat Tommy Godwin's record set in 1939.
He has to cycle more than 75,065 miles in 365 days. The target to beat was 75,065 miles (click here to see how far 75,065 miles is). That is an average of over 205 miles a day, every day, for a year.
Steve was firmly on track to achieve his goal when he was struck by a careless motorcycle rider on 29 March 2015, breaking his leg above the ankle. The accident meant that Steve had to completely stop riding for two weeks - and then resume cycling gradually, using just one leg to pedal. During this recovery period he was riding a modified ICE Vortex racing recumbent trike, which assisted in his rehabilitation to two legged-riding. But he lost thousands of miles against his world record schedule and although his recovery was still not complete he eventually reached a point where he felt he could give his all once more - and launched a second attempt at his Highest Annual Mileage record attempt on 8 August 2015. He abandoned this attempt when it became obvious his fitness had been compromised by the accident and lack of time to recover. He made a third attempt in 2017 and currently holds the record for his age-group.
Steve was backed by a team of volunteers who organised everything from sponsorship and donations to providing food, accommodation and maintenance each night.
Steve on the bike, on Youtube.
Steve set off at a minute past midnight on the 4th of March 2017. This was the start of his third attempt on the HAM'R record for distance cycled in a year. He organisied this attempt rather differently, as detailed on his Facebook page, and invited others to ride with him.
So you want to ride with Steve?
As you can guess, Steve's year record ride has captured the imagination of many a cyclist. Steve received a large number of requests from riders who wanted to spend time either cycling alongside him or have him attend their organised event during his last attempts. Steve is grateful for each and every request along with the support they convey. Steve does welcome company while he is riding, so please read on for advice on the best way to do so. However, complying with all of these requests to ride in your local area or on your event would put his challenge at risk. Let's try and explain why.
Steve announced that he was going to attempt to break the UMCA record for distance cycled in a month (30 days), starting on September 2nd.
At the end of the 30 day period he had broken the record with a total of 7104.3 miles.
He is now continuing his current attempt on the year record. This was broken by Kurt Searvogel in 2016 with 76,076 miles, and again by Amanda Coker this year, with a total of 86,573.2 miles.


Here you can download file Boards and Wards (Boards and Wards Series) PDF. 2shared gives you an excellent opportunity to store your files here and share them with others. Join our community just now to flow with the file Boards and Wards (Boards and Wards Series) PDF and make our shared file collection even more complete and exciting.... Synopsis. With exclusive test-day tips and targeted review from USMLE expert Conrad Fischer, MD, Master the Boards USMLE Step 2 CK gives you the information you need to know to excel on the exam and match into the residency program you want.
Here you can download file Boards and Wards (Boards and Wards Series) PDF. 2shared gives you an excellent opportunity to store your files here and share them with others. Join our community just now to flow with the file Boards and Wards (Boards and Wards Series) PDF and make our shared file collection even more complete and exciting.


When you need to Buy or Sell....call Gayle!
Often referred to as the "gateway to El Dorado County", El Dorado Hills reaches elevations ranging from 200 feet to over 10,800 feet. Located in the scenic mountain foothills of the Sierras, the community is filled with rich history, exquisite shopping, and a wide variety of recreational opportunities. There is literally something for everyone in El Dorado Hills!
El Dorado Hills is a community which offers residents and visitors alike incredible shopping experiences, hotels, services, entertainment and restaurants – all of which make living in this unique community a wonderful experience.
Stretching across the communities of El Dorado Hills, Cameron Park, and Shingle Springs, the Buckeye Union School District educates approximately 4,700 students who attend five neighborhood elementary schools, two middle schools, and a TK-8th grade District operated Charter Montessori. Multiple schools in the district have earned a reward for their excellent educational programs.
Multiple recreational activities can be found in and surrounding El Dorado Hills, including golf courses, whitewater rafting on the American River, camping and fishing. If you aren't quite that adventurous, you can bike on country roads, walk on the trails along small streams, and simply enjoy the many amenities of Folsom Lake.
Are you looking for the perfect home in El Dorado Hills? Contact Gayle Tanner today!


text:
Posts Categorized: Golf
Golf - Insider Content
BACK IN THE SWING OF THINGS
THE MEN'S GOLF TEAM IS ON THE HUNT FOR ITS SECOND CHAMPIONSHIP TITLE PLENTY OF CHANGES took place for the Texas men's golf team between the end of last May...
Texas Men's Golf Earns No. 1 Seed at NCAA South Central Regional Championship
The Longhorns will head to Fayetteville, Ark., for one of six regional championship events next week. The Men's Golf team in front of the UT Tower lit all burnt...
FRESHMAN Brandon Stone was named to the 2013 Ben Hogan Award Watch. The most prestigious award in college men's golf, the Ben Hogan Award is presented annually...
FEATURE – One Last Shot
Golf is a cruel sport. The game changes with each address of the ball as players attempt to temporarily master a task that they could never truly perfect. Playing...
Archive - Golf
FEATURE – A Season For Change, Texas Men's Golf
After decades of walking away from the NCAA Tournament empty handed, the Texas Golf Teams are positioned to make a run for the national title. Awards and Photographs...
CROWNING ACHIEVEMENT
Texas Golf coach John Fields and senior Dylan Frittelli talk strategy during a tournament. THE GOLF COACHES Association of America named senior Dylan Frittelli...
No. 1 Men's Golf Fires Field-Best 5-Under 283 To Improve To Second Place At Big 12 Championship
The No. 1 Texas Men's Golf team fired a field-best 5-under-par 283 in Saturday's third round of the Big 12 Championship at Whispering Pines Golf Club to improve...
Spieth Finishes Tied For 41st At PGA Tour Texas Valero Open
Texas freshman Jordan Spieth shot a final-round 75 Sunday at TPC San Antonio and finished tied for 41st place at 4-over-par 292 (70-72-75). In five career PGA...
Frittelli Named Co-Recipient Of The Byron Nelson Award Presented By Cleveland Golf/Srixon
Texas senior Dylan Frittelli was named co-recipient of the 2012 Byron Nelson Award presented by Cleveland Golf/Srixon, the Golf Coaches Association of America...
YOUNG GUN – Jordan Spieth
Drawn in by the lifestyle of the surrounding city, thousands of college freshman arrive to the 40 Acres each year ready to revel in their new-found freedom....
Page 8 of 8 Previous 1 2 3 … 5 6 7 8


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Q: Easier way of checking Int32.TryParse I am seeing lots of these in a method in our code:
int num1 = 0;
if (Char.IsDigit(myStr[2]) && Int32.TryParse(myStr[2].ToString(), out num1) == false)
{
    valid = false;
}

So are they just making sure the third character us a digit?

A: The code shown parses the 3rd character only - checking if it is digit, then parsing the string representation of that single character. Instead, just use the numeric value of that character:
if(myStr[2] >= '0' && myStr[2] <= '9') {
    num1 = (int)myStr[2] - (int)'0';
} else {
    valid = false
}

A: You can safely skip the IsDigit() check as it's redundant.
TryParse() will fail if it's not a digit.
As it has been pointed out by others, Char.IsDigit() is quicker. If your code is performance sensitive the check makes sense.
If you leave the IsDigit check in place, then you can reduce TryParse to Int32.Parse() as at that point the parsing won't fail.

A: It looks like the code that you have is doing this for efficiency. Whoever coded this, knows the structure of the string in myStr to sometimes have a non-numeric symbol in the third position. That's why he made this optimization to check the third symbol before paying for the conversion of the character array to string which then gets parsed.
Chances are, this optimization is premature: although making a temporary throw-away string is not free, this optimization would make sense only in situations when you do it a lot in a very tight loop. In other words, you do it only if it shows up near the top in your performance profiler's output.
You can optimize this check to avoid if:
int num1 = 0;
valid &= !Char.IsDigit(myStr[2]) || Int32.TryParse(myStr[2].ToString(), out num1);

A: I don't believe you need the first part (it could also throw an IndexOutOfRangeException).
So I would probably use:
int num1 = 0;
if (myStr.Length > 2 && Int32.TryParse(myStr[2].ToString(), out num1) == false)
{
  valid = false;
}

A: Char.IsDigit Method (String, Int32)
Indicates whether the character at the specified position in a specified string is categorized as a decimal digit.
Link
Int32.TryParse Method
Converts the string representation of a number to its 32-bit signed integer equivalent. A return value indicates whether the operation succeeded. This member is overloaded.
Link
Edit:
First I wrote that you can skip any of the check but now I am  writing that you can not because
if (Char.IsDigit(myStr[2]) && Int32.TryParse(myStr[2].ToString(), out num1) == false)
{ }

Char.IsDigit() will return true if myStr[2] contains any of the Unicode characters listed here but Int.TryParse() will not convert any numbers except for 0-9 (not sure about this, as I have not checked all of them) so it will return false which is you are checking...
The condition you are checking can be understood by the following example:
string x = "AS௭s";
int s = 0;
if (Char.IsDigit(x[2]) && int.TryParse(x[2].ToString(), out s) == false)
{
    // even if '௭` is Tamil Digit Seven and 'Char.IsDigit()' will return true but
    // int.TryParse() will return false because it can not convert it
    // so you are setting valid = false when the myStr contains a valid Unicode Character
    // for a digit but It can not be converted to integer by TryParse method...
    valid = false;
}

@Marc Gravell♦'s answer is the best solution for checking this condition...

A: Here's how I'd write it:
int num1 = 0;
try
{
    num1 = Int32.Parse(myStr[2].ToString());
}
catch (Exception)
{
    valid = false;
}

This does the same thing and is a lot easier to read imho, oh & you can log failed parses inside the catch.
Or you can do:
int num1 = 0;
valid = Int32.TryParse(myStr[2].ToString(), out num1);

redpajama_set_name: RedPajamaStackExchange


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Australia Open money boost pleases Djokovic
6:14 am on 3 October 2012
Novak Djokovic has welcomed news that prize money from the Australian tennis Open will rise by almost five million dollars, but the world No.2 is warning that players' fight for a greater share of revenue isn't over yet.
Djokovic described an announcement by the organisers of January's grand slam that the purse would increase to a record $37 million as positive and the Serb urged the other three of tennis's major titles to follow suit.
Following his first-round win at the China Open in Beijing, the 25-year-old three-time winner says the Australian Open organisers have clearly shown understanding for players' demands and what the players had to say, which is really nice to see.
Australian Open organisers boosted prize money on Tuesday following reports in August that players on the ATP Tour, which runs the men's game, were mulling a boycott of the tournament to try to gain a higher percentage of grand slam revenues for themselves.
At issue is the pay of lower-ranked players, who often exit in the first round after making the long journey to Melbourne.
Djokovic says players are still in negotiations behind closed doors with Roland Garros, Wimbledon and the US Open.