Fresh apricots are at their peak for only a short period, and do not keep or travel well. Drying is one method of preserving their goodness, and happily improves the flavour as well. Those Apricots come from Turkey.
Apricots have a smooth velvety skin, soft flesh, and a naturally sweet flavor.
They are a rich source of vitamins, especially beta-carotene, which is responsible for giving apricots their natural yellow-orange color.


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"I Chased Him Down And Whooped His Ass" - JR Smith Caught Someone Smashing His Window And Took Matters Into His Own Hands
Greenie5/31/2020 10:23 PM
Chances are because JR Smith is a famous athlete he's going to have to deal with some assault charges or something, but in all honesty isn't this how any normal person would react if they saw someone smashing their car windows? You can't go around smashing car windows and then not be prepared to get your ass whooped by the owner of said vehicle in my opinion. I don't think it's a stretch to say that stuff like this sort of takes away from the whole message right? Chances are whoever that person is that smashed the window and then got his ass beat by JR isn't out there for the right reasons.
Also to that guy saying stop filming to respect JR's privacy, uhhhhh he's in the street. He's not in the privacy of his own property, of course people are going to film. The sad thing is this will probably be spun in a negative way by some and it'll only do more harm. Yes, it's true that kicking someone in the head like that is pretty fucked up, but so is smashing random people's car windows just for the sake of causing chaos and destruction. Sadly this is probably not the first time we'll see a video like this, and JR will most likely have to deal with this further because he's a public figure, the whole thing just sucks.
So please, everyone stay safe. Don't be that kid. It's possible to voice your opinion and your frustrations in a peaceful manner. A lot of people are out there for the right reasons and have found ways to do it. Going around smashing random car windows isn't that. To me, that does the exact opposite and only adds fuel to the fire.
nba+ 4 Tags

redpajama_set_name: RedPajamaCommonCrawl


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Q: Windbg - how to show the call stack method instead of addresses I'm analyzing a dump and get K command as below
0:034> kp
 # Child-SP          RetAddr               Call Site
00 00000054`e0995fb0 00007ffa`042d28ad     clr!COMNlsInfo::InternalGetCaseInsHash+0x58
01 00000054`e09962b0 00007ffa`042dba85     0x00007ffa`042d28ad
02 00000054`e09962f0 00007ffa`043015df     0x00007ffa`042dba85
03 00000054`e0996330 00007ffa`0431c357     0x00007ffa`043015df
04 00000054`e09963d0 00007ffa`064e6a08     0x00007ffa`0431c357
05 00000054`e0996400 00007ffa`07db6aae     0x00007ffa`064e6a08
06 00000054`e0996440 00007ffa`07db68c9     0x00007ffa`07db6aae
07 00000054`e0996570 00007ffa`07db6070     0x00007ffa`07db68c9
08 00000054`e09965c0 00007ffa`07cf8696     0x00007ffa`07db6070
09 00000054`e09966d0 00007ffa`07ce801f     0x00007ffa`07cf8696
0a 00000054`e0996790 00007ffa`07ce7e90     0x00007ffa`07ce801f
0b 00000054`e09967e0 00007ffa`63561f4c     0x00007ffa`07ce7e90

So could you please tell us how to get more detaisl regarding method name, full call stack about the call site column like 0x00007ffa`07cf8696
Thank you.

A: It looks like you're debugging a .NET application. WinDbg was developed for native debugging. It needs an extension called SOS for debugging .NET. Usually, that extension is shipped with the .NET framework and ready to be loaded.
Try .loadby sos clr to load it. You can then use !clrstack and !dumpstack to see the .NET call stack and !pe to see .NET exceptions.

redpajama_set_name: RedPajamaStackExchange


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ClearIAS » Science and Technology Notes » Vaccine: Definition, Types and Economic aspect
Vaccine: Definition, Types and Economic aspect
What are vaccines and their types? What are the types of Covid vaccinations? What is the economic aspect of vaccine development? Know here.
What are vaccines?
A vaccine is a biological preparation that develops acquired immunity to a particular infectious disease.
Acquired immunity is immunity one develops over a lifetime. It can come from a vaccine, exposure to an infection or disease, or another person's antibodies (infection-fighting immune cells). When pathogens (germs) are introduced into the body from a vaccine or a disease, the body's immune system learns to target those germs in the future by making new antibodies.
A vaccine usually contains an agent that resembles a disease-causing microorganism and is often made from weakened or killed forms of the microbe, its toxins, or its surface proteins.
The agent induces the body's immune system to recognize the agent as a threat and destroy it. The immune system further memorizes to destroy any of the microorganisms associated with that agent that it may encounter in the future.
How do vaccines work?
When viruses or bacteria (germs) invade our body, they attack and multiply. This invasion is called an infection, and the infection is what causes illness.
The first time the body encounters a germ, it can take several days for the immune system to make and use all the tools it needs to fight the infection.
After the infection has been eradicated, the immune system keeps a few "memory cells" that remember what it learned about how to protect against that disease.
If the body encounters the same virus or bacteria again, it will produce antibodies to attack the germ more quickly and efficiently.
Types of vaccines:
Vaccines are made up of viruses or bacteria that are altered or weakened so that they only cause an imitation of the disease and not the disease.
There are a variety of different ways to alter or weaken the viruses or bacteria so that vaccination develops immunity instead of serious disease.
Following are the different types of vaccines based on how they are made:
Live attenuated vaccines have weakened form of the living viruses in them. They are the closest to natural infections hence they quite effective, but everyone cannot get them because people with weakened immune systems like those undergoing chemotherapy, may have adverse reactions. Examples include MMR, chickenpox, and the flu vaccine nasal spray is also known as FluMist.
Toxoid vaccines prevent diseases caused by bacteria that produce toxins (poisons) in the body. These have weakened forms of toxins called toxoids in them. For example, DTaP and Tdap vaccines contain diphtheria and tetanus toxoids, in addition to protection against pertussis.
Inactivated vaccines have viruses in inactivated (killed) form. These vaccines produce immune responses, but cannot cause the disease itself. Examples include hepatitis A, influenza (shot only), polio (shot only), and rabies.
Subunit vaccines use only a part of the virus or bacteria instead of the full organism. They contain only the essential antigens from the causative agent, hence they cannot cause illness. An example is pertussis (whooping cough) component of the DTaP vaccine.
Conjugate vaccines use part of the coating of bacteria called polysaccharides. It is a type of subunit vaccine which combines a weak antigen with a strong antigen as a carrier so that the immune system has a stronger response to the weak antigen. Examples include hepatitis B, HPV, shingles, pneumococcal (PCV13), and meningococcal (MenACY).
Types of CoVID-19 Vaccines:
There are four main types of CoVID 19 vaccinations-
Whole virus vaccine:
These have the live attenuated and inactivated vaccines types.
These require only conventional storage conditions.
India's COVAXIN is an inactivated type.
Protein sub-unit vaccine:
The viral subunit is mixed with adjuvants to help stimulate an immune response.
They are expensive to produce and may require booster doses.
NOVAVAX is of such category.
mRNA (nucleic acid) vaccine:
The RNA code of the SARS CoV-2 virus is inserted into the host cell whose protein machinery interprets it to produce viral antigens.
The host body then produces antibodies in response and develops immunity against the SARS CoV-2.
These are easy to make and cheaper to produce, but this has never been used by humans before.
They require extreme cold storage of -70 degrees Celsius.
Pfizer and Moderna vaccines are such types.
Viral vector vaccine:
They also work by giving cells genetic instructions to produce antigens.
But they differ from nucleic acid vaccines because they use harmless viral vectors like adenovirus to deliver these instructions.
Our cellular machinery is hijacked by them to produce antigens which then trigger the immune response.
They require only conventional cold storage.
COVISHIELD and Russia's Sputnik belong to this category.
What is herd immunity or community immunity?
Herd immunity occurs when a large percentage of a community (the herd) becomes immune to a disease, reducing the spread of disease from person to person. As a result, the whole community becomes protected along with those who are immune.
Community immunity protects everyone and is especially important for people who are vulnerable to diseases but cannot be vaccinated. This includes children too young to be fully vaccinated, people with serious allergies against certain vaccine ingredients, and people with weakened or failing immune systems like patients with cancer, HIV-AIDS, type 1 diabetes, or other health conditions, and people going through medical treatments like chemotherapy.
Community immunity plays an important role in protecting a very small group of people who don't have a strong immune response to vaccines. Such people who cannot get vaccinated depend on a high level of immunization in their communities to help protect them against potentially deadly diseases.
Each vaccine-preventable disease requires a certain percentage of people in a community to be vaccinated in order to prevent the disease from spreading. The exact percentage depends largely upon how easily a disease can spread from person to person.
The economic aspect of vaccine development:
Vaccine manufacturers do not receive licensing until a complete clinical cycle of development and trials prove that the vaccine is safe and has long-term effectiveness, which is followed by a scientific review by a multinational or national regulatory organization, such as the European Medicines Agency (EMA) or the US Food and Drug Administration (FDA).
Countries adopting World Health Organisation (WHO) guidelines for vaccine development and licensure, have their own responsibility to issue national licensure and to manage, deploy and monitor the vaccine throughout its use in each nation.
When a vaccine is licensed, the initial supply will be limited due to variable manufacturing, distribution, and logistical factors. It requires an allocation plan for the limited supply and which population segments should be prioritized to first receive the vaccine.
Vaccines developed for multinational distribution through the United Nations Children's Fund (UNICEF) require pre-qualification by the WHO to ensure international standards of quality, safety, immunogenicity, and efficacy for adoption by numerous countries.
The process requires manufacturing consistency at WHO-contracted laboratories following Good Manufacturing Practice (GMP). When UN agencies are involved in vaccine licensure, individual nations collaborate by issuing marketing authorization and a national license for the vaccine, its manufacturers, and distribution partners; and conducting post-marketing surveillance, including records for adverse events after the vaccination program.
The WHO works with national agencies to monitor inspections of manufacturing facilities and distributors for compliance with GMP and regulatory oversight.
In India, the Drugs Controller General of India who is the head of the department of the Central Drugs Standard Control Organization of the Government of India is responsible for the approval of licenses of specified categories of drugs such as vaccines and others like blood and blood products, IV fluids, and sera.
Patenting:
Vaccines are complex mixtures of biological compounds, and there are no generic vaccines like normal prescription drugs. The vaccine produced by a new facility must undergo complete clinical testing for safety and efficacy by the manufacturer.
For most vaccines, specific processes in technology are patented. These may be replaced by alternative manufacturing methods, but this requires R&D infrastructure and a skilled workforce.
When new vaccines are created, patenting may become a barrier to its wider reach. The peak of the Covid-19 pandemic required increased vaccine production and the intellectual property rights were hindering the cause. The World Trade Organization (WTO) and various governments evaluated if the patent process should be waived to eliminate potential barriers to access for all, though it never came through.
The history of vaccine production is a fascinating tale to know. You can know about when various vaccinations were discovered here- timeline of human vaccines.
Arijit Das says
These notes are very helpfull to me thanks clear ias
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Donald Trump is coming to Detroit next week.
The Detroit Economic Club announced today that the Republican Presidential Nominee will speak to the club at the Detroit Marriott Renaissance Center on Monday.
The program, which is scheduled to begin at noon, will include a luncheon.
Tickets will be made available Wednesday for econ club members and guests.
7 Action News and WXYZ.com will provide complete coverage of the visit.
This will be Trump's first visit to Detroit since he was named the Republican Presidential candidate. He spoke in Toledo last week.
Trump's campaign website only shows his schedule through Friday, so it is not yet clear if he will be holding any other events in the area during his visit.


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text:
Q: What to do when app crashes and Qt Creator (GDB) won't give backtrace? My Qt app is crashing, with no output but this:

QML debugging is enabled. Only use this in a safe environment.
  The program has unexpectedly finished.

When I run it in the debugger, it also crashes really fast and the stacktrace pane in Qt Creator is empty. Any ideas how to debug this?

A: I would try breaking apart your code and testing sections of it, so you can at least narrow the issue down. Saying it crashes really fast doesn't exactly give enough context for us to provide solutions.


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France Overtakes UK as Europe's Top Card Fraud Victim, FICO Map Reveals
LONDON —May 20, 2013 — FICO (NYSE:FICO), a leading predictive analytics and decision management software company, today published an updated map of card fraud in Europe that showed most countries experienced a rise in fraud in 2012. For the first time in years, the UK did not have the highest card fraud losses in Europe — France took its place, with 29 percent of the region's losses, compared to the UK's 27 percent.
"France was the founder of the chip and PIN strategy for Europe, but the UK has taken a particularly tough stance against fraud in recent years, using the latest advanced fraud technology," said Martin Warwick, FICO's fraud chief for Europe. "Despite a rise of 14 percent last year, UK card fraud losses were still 36 percent lower in 2012 than at their peak in 2008. By contrast, France's overall fraud losses grew 65 percent between 2007 and 2012, which translated to an additional €174 million of card fraud losses over the period. France also has the highest lost-and-stolen card fraud level of all the countries in Europe."
According to data supplied by Euromonitor International, a provider of global strategic market intelligence, European card fraud losses were 6 percent higher than in 2011. France, Russia and the UK made up more than 80 percent of this increase, and France alone generated nearly half of the total increase in value. Russia's fraud loss has grown the fastest however, with 2012 totals reaching three times the level of those reported in 2010.
"Any successful reduction in fraud, like that driven by Chip & PIN, typically results in criminals changing their modus operandi to find a different weak spot, and fraud levels starting to climb again," said Warwick. "Fraud is like a balloon — if you squeeze it out of one scheme, or one country, it bulges somewhere else.
"In addition, clamping down on fraud can help banks minimize losses but can also result in a more frustrating customer experience, as shoppers' cards may be blocked unnecessarily. When the negative impact on customers outweighs the benefits of tighter fraud prevention methods, banks relax their controls, inevitably leading to another rise in fraud. This means fraud losses tend to follow a saw-tooth pattern, with alternating peaks and troughs. Europe's last peak was in 2008, and after a drop in 2009, levels have been steadily climbing since."
FICO's European Fraud Map shows card fraud amounts from 2006-2012 for 21 countries, across five categories, including counterfeit fraud, card stolen and ID theft. Country-specific information shows how fraud has evolved, and indicates new risks in areas such as ID theft, counterfeit cards and online fraud. Regional trends include the increase in card-not-present (CNP) fraud online. The map can be accessed at www.fico.com/fraudeurope.
FICO's fraud solutions help banks manage their enterprise fraud challenges. FICO® Falcon® Fraud Manager is the world's leading card fraud management solution, and protects more than 2.5 billion payment cards worldwide.
FICO (NYSE:FICO) delivers superior predictive analytics solutions that drive smarter decisions. The company's groundbreaking use of mathematics to predict consumer behavior has transformed entire industries and revolutionized the way risk is managed and products are marketed. FICO's innovative solutions include the FICO® Score — the standard measure of consumer credit risk in the United States — along with industry-leading solutions for managing credit accounts, identifying and minimizing the impact of fraud, and customizing consumer offers with pinpoint accuracy. Most of the world's top banks, as well as leading insurers, retailers, pharmaceutical companies and government agencies, rely on FICO solutions to accelerate growth, control risk, boost profits and meet regulatory and competitive demands. FICO also helps millions of individuals manage their personal credit health through www.myFICO.com. FICO: Make every decision count™.
FICO, Falcon and "Make every decision count" are trademarks or registered trademarks of Fair Isaac Corporation in the United States and in other countries.


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Tracy Chapman Biography, Life, Interesting Facts
Pop Singer, Songwriter
Cleveland, Ohio, United States of America
Chinese Zodiac :
Birth Element :
Tracy Chapman is an American Pop singer and songwriter born in March 30th, 1964. She has won the Grammy Award four times in her music career. The musician with a beautiful voice is known for her songs "Baby Can I Hold You" and "Talkin' 'bout a Revolution."
Tracy Chapman was born a singer. She was only eight years old when she began penning down songs and playing the guitar. Even more amazingly, she started playing ukulele at the age of three. Besides singing, she is also politically active. She supports humanitarian activities and is known especially for her support towards Make Poverty History.
Tracy Chapman was born on March 30th, 1964. Her place of birth is in Cleveland, Ohio in the United States. Her mother raised her on her own and greatly supported her music talent. With the little money she made, her mother bought her a ukulele. Tracy Chapman was just three at the time. When she turned eight, she started playing guitar having been inspired by Hee Haw Television show which she liked watching. During this time, she also wrote her songs.
Tracy Chapman schooled in Episcopal high school having been raised a Baptist. Later, she joined Wooster School situated in Connecticut. Subsequently, she enrolled in Tufts University. After her studies, she earned a bachelor's degree in African studies and anthropology. During this time as a student, Tracy Chapman continued nurturing her music career. She would perform her songs in Boston while recording other songs.
In 1986, Tracy Chapman had a golden opportunity to work with Elektra Records' manager. She recorded her first album Tracy Chapman rose which was released in 1988. The album was ranked no.1 both in the UK and the US that year.
Among the singles of the album was "Fast Car," which was quite popular. In fact, it was rated position six on the US charts and position 5 in that of UK. In 1989, she was the best female pop vocal performer, best new artist, and best contemporary folk album. Therefore, she proudly earned three Grammy Awards.
In 1989, Tracy Chapman recorded her other album Crossroads. She also co-produced the album which included the single song "Freedom Now." This was a dedication to Nelson Mandela, the former president of South Africa. However, this second album was not as successful compared to her first.
Tracy Chapman's third album was titled Matters of the Heart released in 1992. This was followed by New Beginning in 1995 with "Give Me One Reason," among its singles. This was one of the famous songs in the album. In 1997, the song also earned Tracy Chapman her 4th Grammy Award.
The other albums Tracy Chapman has released in her music career include: Telling Stories in 2000. In 2008 she released Our Bright Future. Since then she has constantly avoided the spotlight.
In the mid-1990s Tracy Chapman was involved with another woman, Alice Walker. However, she has never revealed anything concerning her sexual orientation. She does not like mixing her private life with her work.
March 30 Horoscope
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Connie Francis
More People From Ohio
Buster Douglas
Roger Staubach
Art Tatum
Tre Brooks
Tim Urban
More Aries People
Norman Borlaug
Emmy Noether
More Chinese Dragon People
Anthony Weiner
Rielle Hunter


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The hilariously prophetic Onion
Twenty-eight years ago a milestone publication was launched: The Onion, a brilliant satirical magazine that has never been surpassed. This is what an article looks like — one that was published fifteen years ago and belongs to my favourites:
The article (click the screen grab to read the whole piece) goes on to say that Bush swore he would do everything in his power to undo the damage wrought by Clinton's two terms in office, including going into massive debt to develop expensive and impractical weapons technologies, and passing sweeping budget cuts to drive the mentally ill out of hospitals and onto the street. "During the 40-minute speech," Onion claimed, "Bush also promised to bring an end to the severe war drought that plagued the nation under Clinton, assuring citizens that the U.S. will engage in at least one Gulf War-level armed conflict in the next four years."
How prophetic can you get? The article continues with the claim that Bush planed a 250 percent boost in military spending and quotes him saying: "Unlike my predecessor, I am fully committed to putting soldiers in battle situations. Otherwise, what is the point of even having a military?" On the economic side Bush vowed to "bring back economic stagnation by implementing substantial tax cuts, which would lead to a recession, which would necessitate a tax hike, which would lead to a drop in consumer spending, which would lead to layoffs, which would deepen the recession even further." It is difficult to believe that this was written before the Iraq invasion, before the tax cuts for the wealthy and before the resulting world-wide recession.
Let's see what they have published today, just after Donald Trump has announced his pick as running mate on his presidential ticket.
Click the above screen grab for the whole story. This is class humour, trademark Onion. One of my all-time favourites is the following piece. Before quoting it I should mention that I have a dear friend from Armenia named Lilit Mkrtchian (or spelt Mkrttschjan in Germany, where she lives). I need to tell her about the following Onion story, which appeared twenty years ago.
Clinton Deploys Vowels to Bosnia;
Cities of Sjlbvdnzv, Grzny to Be First Recipients
December 1995 — Before an emergency joint session of Congress yesterday, President Clinton announced US plans to deploy over 75,000 vowels to the war-torn region of Bosnia. The deployment, the largest of its kind in American history, will provide the region with the critically needed letters A, E, I, O and U, and is hoped to render countless Bosnian names more pronounceable.
"For six years, we have stood by while names like Ygrjvslhv and Tzlynhr and Glrm have been horribly butchered by millions around the world," Clinton said. "Today, the United States must finally stand up and say 'Enough.' It is time the people of Bosnia finally had some vowels in their incomprehensible words. The US is proud to lead the crusade in this noble endeavour."
The deployment, dubbed Operation Vowel Storm by the State Department, is set for early next week, with the Adriatic port cities of Sjlbvdnzv and Grzny slated to be the first recipients. Two C-130 transport planes, each carrying over 500 24-count boxes of "E's," will fly from Andrews Air Force Base across the Atlantic and airdrop the letters over the cities.
Citizens of Grzny and Sjlbvdnzv eagerly await the arrival of the vowels. "My God, I do not think we can last another day," Trszg Grzdnjkln, 44, said. "I have six children and none of them has a name that is understandable to me or to anyone else. Mr. Clinton, please send my poor, wretched family just one 'E.' Please."
Said Sjlbvdnzv resident Grg Hmphrs, 67: "With just a few key letters, I could be George Humphries. This is my dream."
The airdrop represents the largest deployment of any letter to a foreign country since 1984. During the summer of that year, the US shipped 92,000 consonants to Ethiopia, providing cities like Ouaouoaua, Eaoiiuae, and Aao with vital, life-giving supplies of L's, S's and T's.
You must admit: the above is seriously funny. Make an occasional trip to this wonderful satirical page to lighten up your day.
Auto-numbering and glossing linguistics examples in R Markdown
Erwin Lares
Frequently Asked Questions Concerning Our Invasion of Your Planet
H. L. Warren in Jane Austen's Wastebasket


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Scheme to 'share environmentally-friendly patents'
By: Katherine Nightingale
By Katherine Nightingale
Large corporations have joined forces in an 'open innovation' project to allow public access to patents with environmental benefits.
IBM, Nokia, Pitney Bowles and Sony, in partnership with the World Business Council for Sustainable Development (WBCSD), have compiled a portfolio of patents — the Eco-Patent Commons — that can be used in manufacturing and business processes.
The list of patents was made available this week (14 January).
Companies can pledge patents that save energy and water, reduce the production of hazardous waste, increase recycling or reduce the amount of material used in a process.
Sony, for example, has pledged a patent for recycling old mobile phones into digital cameras and other electrical equipment, with the aim of increasing the amount of material that can be reused in the electronics industry.
The organisers hope that the scheme will encourage researchers and industry to create, use and develop processes in an environmentally responsible way.
George Weyerhaeuser, senior fellow at the WBCSD, said the Council is realistic about the initiative's immediate impact. "At the outset, we can only hope for a modest impact on the environment and businesses in developing countries," he told SciDev.Net.
"I expect this new way of doing business will take some time to catch on. Open innovation is getting well known in some sectors, like [open source in] information technology. But the idea is still very unusual for many businesses."
Weyerhaeuser says that the scheme was designed with the needs of developing countries in mind — though not uniquely so. "Intellectual property rights are mentioned often as a barrier to technology transfer. The commons will help with that issue."
Graham Dutfield, professor of International Governance at the UK-based University of Leeds, gave the scheme a cautious welcome.
He says that the businesses involved are well known for holding non-innovative patents. "One wonders if the patents [they are] supposedly giving up are the ones that are for genuine inventions or those that are not."
Dutfield told SciDev.Net that, while IBM is pursuing initiatives to make it seem like an "open source camp", many of those are "a sophisticated form of intellectual property management that is tailored to specific technological fields in order to secure market advantages in each one of them".
"But if IBM and the other companies involved are really serious about this then it can be a really good thing."
'Open source' urged for TB drug design effort
World Business Council for Sustainable Development
Eco-Patent Commons
More on intellectual property
Scientists and subscription journals tussling for power
Research fairness tool reveals policy gaps
Argentine NGO objects to antiretroviral patent request
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Innovation hub ranking reveals global divide
View on Private Sector: Pharma shift won't help poorest
Patents fail to boost crop yields
Africa's inventors shackled by bad IP regimes
Innovation falling away in parts of developing world
Africa needs IP protection to build knowledge economies
Red tape blamed for hindering Asian innovation
India takes its own path on energy and climate change


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miRBase
8 publications mentioning hsa-mir-3065
Open access articles that are associated with the species Homo sapiens and mention the gene name mir-3065. Click the [+] symbols to view sentences that include the gene name, or the word cloud on the right for a summary.
[+] score: 52
Other miRNAs from this paper: hsa-mir-338, hsa-mir-657, hsa-mir-761, hsa-mir-1250, hsa-mir-4739
Given that two of the top predicted targets are likely oncogenes, it is possible that the role of MIR3065 is to suppress expression of these oncogenes. [score:7]
Perhaps the most compelling support implicating MIR3065 and BC comes from a recent study by Perrson et al. in which NGS expression analysis in paired normal and breast tumor tissue demonstrates a strikingly disparate expression pattern for MIR3065 [18]. [score:5]
Additionally, AATK contains three more miRNAs in close proximity to miR-3065: miR-657, miR-338 and miR-1250 To better understand the implications of inherited susceptibility to BC that may involve BAIAP2, we examined expression of this gene in human tissues using data from the Genotype-Tissue Expression (GTEx) project portal version 6 [45]. [score:5]
While tissue MIR3065 expression was highest in breast tumors in a panel of nine human tissues, both lung and placenta demonstrated the next highest expression levels. [score:5]
Among TargetScan's (release 6.2, June 2012) MIR3065 gene top 15 predicted gene targets are the top hit AT-rich interaction domain 4B, ARID4B (alias BRCAA1, breast cancer antigen epitope-1) and RAB22A, a member of the RAS oncogene family of small GTPases involved in signal transduction [62– 65]. [score:5]
All four SNPs reside in a genomic region that includes the first intron of the brain-specific angiogenesis inhibitor 1 -associated protein 2 (BAIAP2), as well as the predicted primary transcript for MIR3065. [score:3]
Given their genomic location within the intron of BAIAP2 and pri- MIR3065 sequence, these four SNPs have the potential to impact BAIAP2 expression, BAIAP2 gene intron 1 binding proteins, and/or MIR3065 biogenesis. [score:3]
It is also possible that the pri- MIR3065 SNP associated with BC (or a SNP in LD) impairs MIR3065 processing, leading to lower levels of mature MIR3065 and reduced inhibition of these oncogenes. [score:3]
This complex and gene-dense region contains BAIAP2, a protein-coding gene, and MIR3065, an important nonprotein coding regulatory gene, which may play key roles in BC development and heterogeneity among AA women. [score:3]
These SNPs reside in a genomic location that includes both the predicted primary transcript of the noncoding miRNA gene MIR3065 and the first intron of the gene for brain-specific angiogenesis inhibitor 1 -associated protein 2 (BAIAP2). [score:3]
Mature MIR3065 resides in a gene adjacent to BAIAP2 known as apoptosis -associated tyrosine kinase (AATK) where it is located in the seventh intron and is transcribed in the opposite direction from its host gene. [score:2]
Germline genetic variation indicates that MIR3065 may play an important role in BC development and heterogeneity among AA women. [score:2]
For example, in addition to supporting the potential role of MIR3065 in BC, Perrson et al. also uncovered a new miRNA in a very well-studied region within the intron of ERBB2/HER2, a major predictive marker in BC [18]. [score:1]
Similar to previous studies, through BAC array comparative genomic hybridization (CGH), MIR3065 was also identified as a gene encoded in a region with high-level genomic amplification in luminal B, ERBB2/HER2 -positive, ER positive, and ER negative subtypes. [score:1]
In this gene (AATK) and miRNA-rich region, mature MIR3065 and mature MIR338 share the same genomic location but are transcribed from opposite DNA strands (Fig. 2) [44]. [score:1]
Fig. 2Chromosome 17 position GRCh37/hg19: 79,008,947–79,105,748, encompassing breast cancer -associated SNPs, defined promoter, primary, precursor, mature and 3'-UTR, miR-3065 gene regions and other overlapping coding genes. [score:1]
Functional assessment of the BC -associated SNPs in BAIAP2 and MIR3065 are needed to identify the potential molecular mechanism behind their association with BC risk, in particular the risk of ER positive BC, the most common subtype. [score:1]
Included among these SNPs was rs73410309 within the precursor sequence of MIR4739 located on chromosome 17q25.3 (OR = 1.1; p = 0.039), which is approximately 1.5 Mb from our top hit in MIR3065 (rs9913477) and not in high LD with this SNP (D' = 0.007 and R [2] = 0.0) based on AFR 1000 Genomes reference panel [57]. [score:1]
[1 to 20 of 18 sentences]
Other miRNAs from this paper: hsa-mir-99a, hsa-mir-122, hsa-mir-99b, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, hsa-mir-548q, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-548am, hsa-mir-548an, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, hsa-mir-548ay, hsa-mir-548az, hsa-mir-548ba, hsa-mir-548bb, hsa-mir-548bc
Furthermore, a synergistic anti-TI effect of hsa-miR-3065-3p may inhibit the three viruses in a multi-target fashion, where downregulation of one virus may down-regulate the other two. [score:11]
We conclude that hsa-miR-3065-3p could be utilized as a potential target for antiviral therapeutics for TI patients and also in mono-infected patients. [score:3]
However, hsa-miR-3065-3p may indirectly be beneficial by silencing of HIV-1, which causes immunodeficiency and may be at least partially responsible for increasing the replications of and HBV (29). [score:2]
Hence, through our computational analysis, we propose the utility of hsa-miR-3065-3p in TI patients as a potential therapeutic agent infected with/HIV-1/HBV It is worth mentioning that hsa-miR-122 has been the subject of intensive investigations around the globe, and it has been fairly well established that this miRNA appears to play a crucial role in upregulating intracellular replication in hepatic cells (12, 13, 21, 22, 24). [score:2]
Here, we show via computational analysis that hsa-miR-3065-3p could be used as a therapeutic marker for treatment of triple infections (i. e., HIV-1, and HBV). [score:1]
We also performed computational analysis for 1,527 hsa-miRs to assess their alignment with all six genotypes of and found that hsa-miR-3065-3p was the only miRNA that aligned with genotype 1, as well as with HIV-1 and HBV. [score:1]
hsa-miR-3065 identity with, HIV-1, and HBV. [score:1]
As shown in Table 1, hsa-miR-3065-3p exhibited significant identity with all three viruses. [score:1]
Hsa-miR-122 shows an imperfect identity at seed residue position #4 and hsa-miR-3065-3p shows an imperfect identity at seed residue position #7 in the seed sequence (2–8 bps) to the genome (Table 1). [score:1]
Our analyses identified that hsa-miR-3065-3p shares significant mutual identity with all three viruses. [score:1]
The main focus of this study is hsa-miR-3065-3p and not hsa-miR-122, hsa-miR-99, or has-miR-548. [score:1]
We present evidence that hsa-miR-3065-3p may have a potential therapeutic application in TI patients, as well as in mono-infected individuals (12– 16). [score:1]
Here, we present evidence using essential components of bioinformatics tools, and hypothesize that utility of hsa-miR-3065-3p and perhaps miR-548 would be potential antiviral therapeutic agents in the treatment of TI patients because it shows near perfect alignment in the seed region for all three viruses. [score:1]
We analyzed the identity of hsa-miR-3065-3p through computational analysis and came to the conclusion that it is perhaps a better miRNA than hsa-miR-122 as a therapeutic agent for infection alone or for treatment of TI patients suffering from, HIV-1, and HBV. [score:1]
hsa-miR-3065 identity with, HIV-1, and HBVHere, we show via computational analysis that hsa-miR-3065-3p could be used as a therapeutic marker for treatment of triple infections (i. e., HIV-1, and HBV). [score:1]
The 'mature' and 'stem-loop' sequences for hsa-miR-122 and hsa-miR-3065 were obtained from the 'miRBase' database (http://www. [score:1]
However, neither of the two miRNAs (i. e. hsa-miR-3065-3p and hsa-miR-122) exhibited 100% identity with. [score:1]
However, an overall high identity of hsa-miR-3065-3p to all three viruses may still make this miRNA a strong candidate against all three viruses. [score:1]
As summarized in Table 1, we also show that three hsa-miRs (miR-3065-3p, miR-99, and miR-548) exhibited a significant mutual identity to genomic sequences of these three viruses. [score:1]
We identified one unique miRNA, hsa-miR-3065-3p, that shares significant mutual identity to these three viral genomes (∼61–83%). [score:1]
Triple infection and hsa-miR-3065 identityAll TI viruses share similar modes of transmission that include blood to blood contact, sexual contact with an infected person, or vertical (mother to child) transmission. [score:1]
Triple infection and hsa-miR-3065 identity. [score:1]
[+] score: 7
Other miRNAs from this paper: hsa-mir-192, hsa-mir-196a-1, hsa-mir-196a-2, hsa-mir-203a, hsa-mir-205, hsa-mir-215, hsa-mir-224, hsa-mir-145, hsa-mir-149, hsa-mir-338, hsa-mir-335, hsa-mir-491, hsa-mir-551b, hsa-mir-708, hsa-mir-944, hsa-mir-1260b, hsa-mir-203b
83 (0.13) −0.07 (1.0) hsa-miR-551b-3p ND ND ND hsa-miR-3065-5p −1.4 (0.03) −2.2 (0.002) −0.74 (1.0) hsa-miR-196a-5p 0.23 (1.0) 0.07 (1.0) −0.31 (1.0) BE, Barrett's esophagus; GERD, Gastroesophageal reflux disease; EE refers to those GERD patients with erosive esophagitis; NERD (Non-erosive reflux disease) refers to those GERD patients without erosive disease; NGS, next generation sequencing; negative numbers indicate downregulation in BE compared to GERD; 1 Fold changes by RT-PCR calculated by ΔΔCt method; 2 p-value was adjusted for false discovery rate of 5% and reported in parentheses; miRs-4253, -4776-3p, -548n and -675-3p were also significantly different but with reads <25 in each group and were not included for RT-PCR validation; ND, not detected. [score:7]
[1 to 20 of 1 sentences]
Other miRNAs from this paper: hsa-mir-17, hsa-mir-18a, hsa-mir-19a, hsa-mir-19b-1, hsa-mir-19b-2, hsa-mir-20a, hsa-mir-21, hsa-mir-23a, hsa-mir-24-1, hsa-mir-24-2, hsa-mir-27a, hsa-mir-30a, hsa-mir-32, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-93, hsa-mir-107, hsa-mir-129-1, hsa-mir-30c-2, hsa-mir-139, hsa-mir-181c, hsa-mir-204, hsa-mir-212, hsa-mir-181a-1, hsa-mir-222, hsa-mir-15b, hsa-mir-23b, hsa-mir-132, hsa-mir-138-2, hsa-mir-140, hsa-mir-142, hsa-mir-129-2, hsa-mir-138-1, hsa-mir-146a, hsa-mir-154, hsa-mir-186, rno-mir-324, rno-mir-140, rno-mir-129-2, rno-mir-20a, rno-mir-7a-1, rno-mir-101b, hsa-mir-29c, hsa-mir-296, hsa-mir-30e, hsa-mir-374a, hsa-mir-380, hsa-mir-381, hsa-mir-324, rno-mir-9a-1, rno-mir-9a-3, rno-mir-9a-2, rno-mir-15b, rno-mir-17-1, rno-mir-18a, rno-mir-19b-1, rno-mir-19b-2, rno-mir-19a, rno-mir-21, rno-mir-23a, rno-mir-23b, rno-mir-24-1, rno-mir-24-2, rno-mir-27a, rno-mir-29c-1, rno-mir-30e, rno-mir-30a, rno-mir-30c-2, rno-mir-32, rno-mir-92a-1, rno-mir-92a-2, rno-mir-93, rno-mir-107, rno-mir-129-1, rno-mir-132, rno-mir-138-2, rno-mir-138-1, rno-mir-139, rno-mir-142, rno-mir-146a, rno-mir-154, rno-mir-181c, rno-mir-186, rno-mir-204, rno-mir-212, rno-mir-181a-1, rno-mir-222, rno-mir-296, rno-mir-300, hsa-mir-20b, hsa-mir-431, rno-mir-431, hsa-mir-433, rno-mir-433, hsa-mir-410, hsa-mir-494, hsa-mir-181d, hsa-mir-500a, hsa-mir-505, rno-mir-494, rno-mir-381, rno-mir-409a, rno-mir-374, rno-mir-20b, hsa-mir-551b, hsa-mir-598, hsa-mir-652, hsa-mir-655, rno-mir-505, hsa-mir-300, hsa-mir-874, hsa-mir-374b, rno-mir-466b-1, rno-mir-466b-2, rno-mir-466c, rno-mir-874, rno-mir-17-2, rno-mir-181d, rno-mir-380, rno-mir-410, rno-mir-500, rno-mir-598-1, rno-mir-674, rno-mir-652, rno-mir-551b, rno-mir-344b-2, rno-mir-3564, rno-mir-3065, rno-mir-1188, rno-mir-3584-1, rno-mir-344b-1, hsa-mir-500b, hsa-mir-374c, rno-mir-29c-2, rno-mir-3584-2, rno-mir-598-2, rno-mir-344b-3, rno-mir-466b-3, rno-mir-466b-4
Finally, miR-30c-2-3p, miR-101b-3p, miR-142-3p, miR-142-5p, miR-181a-1-3p, miR-374-5p, miR-466c-3p, miR-1188-3p, miR-3065-3p and miR-3582 were significantly down-regulated in the chronic stage (Supplementary Fig. S7D). [score:4]
Other miRNAs from this paper: hsa-mir-21, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-26a-2, hsa-mir-338, hsa-mir-559, hsa-mir-1291, hsa-mir-1246, hsa-mir-1248, hsa-mir-1973, hsa-mir-3130-1, hsa-mir-3130-2, hsa-mir-4284
This phenomenon showed that both strands of specific genomic region could be transcribed to generate the same mature miRNAs (for example, hsa-mir-3130-1 and hsa-mir-3130-2, Figure 2C) or different mature miRNAs (for example, hsa-mir-338 and hsa-mir-3065, Figure 2A). [score:1]
For example, both hsa-miR-338-5p and hsa-miR-338-3p could be accurately mapped to the opposite strand of hsa-mir-3065 (Figure 2A). [score:1]
These two miRNA genes shared consensus sequences, in which hsa-mir-338 was a part of the opposite strand of hsa-mir-3065 (Figure 2A). [score:1]
In fact, these two miRNAs were generated from sense and antisense strands of the same genomic location according to the miRBase annotation (hsa-mir-338: chromosome 17 (−): 79,099,683–79,099,749; and hsa-mir-3065: chromosome 17 (+): 79,099,677–79,099,755). [score:1]
Other miRNAs from this paper: hsa-let-7f-1, hsa-let-7f-2, hsa-mir-17, hsa-mir-26a-1, hsa-mir-26b, hsa-mir-98, mmu-mir-30b, mmu-mir-138-2, mmu-mir-143, hsa-mir-30b, hsa-mir-138-2, hsa-mir-143, hsa-mir-138-1, mmu-let-7f-1, mmu-let-7f-2, mmu-mir-26a-1, mmu-mir-26b, mmu-mir-98, mmu-mir-148b, mmu-mir-342, mmu-mir-350, mmu-mir-135b, mmu-mir-17, mmu-mir-26a-2, mmu-mir-138-1, hsa-mir-26a-2, hsa-mir-362, mmu-mir-362, hsa-mir-376c, hsa-mir-342, hsa-mir-135b, hsa-mir-148b, mmu-mir-470, hsa-mir-490, mmu-mir-542, hsa-mir-487b, mmu-mir-376c, mmu-mir-487b, hsa-mir-574, hsa-mir-542, mmu-mir-744, mmu-mir-672, mmu-mir-674, mmu-mir-490, mmu-mir-466h, mmu-mir-574, mmu-mir-873a, hsa-mir-744, hsa-mir-873, mmu-mir-669j, mmu-mir-1930, mmu-mir-1934, mmu-mir-1942, mmu-mir-3064, mmu-mir-3065, mmu-mir-3069, mmu-mir-3071, mmu-mir-3073a, mmu-mir-3092, mmu-mir-3093, mmu-mir-3109, hsa-mir-3064, mmu-mir-3073b, mmu-mir-873b
01 Stress response, cell proliferation miR-542 ↓2.60 NA miR-574 ↑2.09 Inflammation (Tlr9 activation), cell proliferation, apoptosis miR-669j ↑3.12 NA miR-672 ↑2.40 NA miR-674 ↑2.19 NA miR-744 ↑4.35Oncogene (Tgf) suppression miR-873 ↑2.53 ↑3.22 NA miR-1930 ↑3.31 NA miR-1934 ↑2.17 ↑3.27 NA miR-1942 ↑2.49 NA miR-3064 ↑2.50 NA miR-3065 ↑3.20 NA miR-3069 ↑2.98 NA miR-3071 ↑3.51 NA miR-3073 ↓2.78 NA miR-3092 ↑3.48 NA miR-3093 ↑3.28 NA miR-3109 ↓2.07 NAAll reported variations were statistically significant (P < 0.05). [score:3]
Other miRNAs from this paper: hsa-mir-200b, hsa-mir-301a, hsa-mir-515-1, hsa-mir-515-2, hsa-mir-548a-1, hsa-mir-548b, hsa-mir-548a-2, hsa-mir-548a-3, hsa-mir-548c, hsa-mir-548d-1, hsa-mir-548d-2, hsa-mir-548e, hsa-mir-548j, hsa-mir-548k, hsa-mir-548l, hsa-mir-548f-1, hsa-mir-548f-2, hsa-mir-548f-3, hsa-mir-548f-4, hsa-mir-548f-5, hsa-mir-548g, hsa-mir-548n, hsa-mir-548m, hsa-mir-548o, hsa-mir-548h-1, hsa-mir-548h-2, hsa-mir-548h-3, hsa-mir-548h-4, hsa-mir-548p, hsa-mir-548i-1, hsa-mir-548i-2, hsa-mir-548i-3, hsa-mir-548i-4, mml-mir-301a, mml-mir-548a, mml-mir-548b, mml-mir-548c, mml-mir-548d, mml-mir-548e, mml-mir-548f, ptr-mir-301a, ptr-mir-515-1, ptr-mir-515-2, ptr-mir-548a-1, ptr-mir-548a-2, ptr-mir-548b, ptr-mir-548c, ptr-mir-548f-1, ptr-mir-548f-2, ptr-mir-548h, ptr-mir-548i-1, ptr-mir-548i-2, ptr-mir-548i-3, ptr-mir-548i-4, ptr-mir-548i-5, ptr-mir-548j, ptr-mir-548k, ptr-mir-548l, ptr-mir-548n, ptr-mir-548p, hsa-mir-2115, hsa-mir-548q, hsa-mir-2681, hsa-mir-548s, hsa-mir-548t, hsa-mir-548u, hsa-mir-548v, hsa-mir-548w, hsa-mir-548x, ppy-mir-515-1, ppy-mir-515-2, hsa-mir-548y, hsa-mir-548z, hsa-mir-548aa-1, hsa-mir-548aa-2, hsa-mir-548o-2, hsa-mir-548h-5, hsa-mir-548ab, hsa-mir-548ac, hsa-mir-548ad, hsa-mir-548ae-1, hsa-mir-548ae-2, hsa-mir-548ag-1, hsa-mir-548ag-2, hsa-mir-548ah, hsa-mir-548ai, hsa-mir-548aj-1, hsa-mir-548aj-2, hsa-mir-548x-2, hsa-mir-548ak, hsa-mir-548al, hsa-mir-4511, hsa-mir-548am, hsa-mir-548an, hsa-mir-4691, hsa-mir-203b, hsa-mir-4760, hsa-mir-4762, hsa-mir-548ao, hsa-mir-548ap, hsa-mir-548aq, hsa-mir-548ar, hsa-mir-548as, hsa-mir-548at, hsa-mir-548au, hsa-mir-548av, hsa-mir-548aw, hsa-mir-548ax, ptr-mir-548o, ptr-mir-548e, ggo-mir-548b, ggo-mir-203b, ggo-mir-548c, ggo-mir-548e, ggo-mir-548a, ggo-mir-548d, ggo-mir-548f, ggo-mir-200b, ppy-mir-548e, ppy-mir-548a, ppy-mir-548h, ppy-mir-548f, ppy-mir-548c, hsa-mir-548ay, hsa-mir-548az, mml-mir-548g, mml-mir-548h, mml-mir-548i, mml-mir-548j, hsa-mir-548ba, hsa-mir-548bb, ggo-mir-515-1, ggo-mir-515-2, ppy-mir-515-3, hsa-mir-548bc, ggo-mir-301a, ppy-mir-301a
While in the orangutan, the binding sites of GATA2 have been discovered in the upstream sequences of the five intergenic miRNA genes except ppy-mir-200b, ppy-mir-203b and ppy-mir-3065 (Table S6). [score:1]
Other miRNAs from this paper: hsa-let-7a-1, hsa-let-7a-2, hsa-let-7a-3, hsa-let-7b, hsa-let-7c, hsa-let-7d, hsa-let-7e, hsa-let-7f-1, hsa-let-7f-2, hsa-mir-22, hsa-mir-26b, hsa-mir-92a-1, hsa-mir-92a-2, hsa-mir-99a, hsa-mir-129-1, hsa-let-7g, hsa-let-7i, hsa-mir-124-1, hsa-mir-124-2, hsa-mir-124-3, hsa-mir-128-1, hsa-mir-141, hsa-mir-191, hsa-mir-129-2, hsa-mir-128-2, hsa-mir-99b, hsa-mir-375, hsa-mir-486-1, hsa-mir-486-2, hsa-mir-6529
For example, miR-2964-3p and miR-3065-5p were detected only by the Bioo Scientific kit. [score:1]
Comments, questions? Email mirbase@manchester.ac.uk


text:
By Baz Macdonald
Have we been slow and irresponsible with our vaccinations? And if so, why? Re: Journalist Baz Macdonald unpacks our vaccination approach.
Throughout 2021, opposition politicians have been saying our vaccine rollout was too slow.
We gave our first dose on February 3, when the rest of the world had already delivered 117 million doses. By July 30, when we opened vaccinations up to the general public, we had fully vaccinated only 15 percent of the country. Only two weeks later we were hit with the current breakout of the highly infectious Delta strain of the virus.
Now, as the rollout ramps up - with a record high 87,000 doses administered on Thursday - National Party Covid-19 Reponse spokesperson Chris Bishop says it may just be too little, too late.
"We are the slowest in the developed world, and it has left us a sitting duck to the Delta variant of COVID-19, which, of course, has now made its way into the community," Bishop says.
As of Wednesday August 25, New Zealand had administered over 3 million doses of the Pfizer Covid-19 vaccine. A little over a million New Zealand people have now received both doses.
It may sound like a lot, but that means only 39 percent of our population are even partly vaccinated and just over a fifth fully vaccinated.
In fact, we have actually administered the fewest vaccines of any country in the OECD - a group of other democracies with similarly developed economies.
But, despite our ranking on the world stage, the Government continues to stand by its plan, reiterating the rollout is not just on-track, but actually ahead of schedule.
Why is it then that being last in the developed world for vaccine delivery was part of the plan?
The planned and actual rollout of New Zealand's Covid-19 Vaccines. Source: Ministry of Health.
Our people aren't dying
For Prime Minister Jacinda Ardern, justification for New Zealand's slower-paced vaccination rollout is simple. In many other countries, people are dying from the virus - that hasn't been a problem here.
In an interview on Q+A in April, Ardern implied that New Zealand had intentionally taken a backseat in vaccine rollouts so other countries who needed them more would have access.
"We absolutely accepted that we wouldn't be the first rolling out. The calculation in New Zealand is so different, our people aren't dying," Ardern said.
"And so that does mean that some countries, some who may have received their agreements after us, received their vaccines before we did."
However, it's not clear how that decision was made. Did we make the decision to move further back in the queue? Did other Governments ask us to? Did Pfizer make the decision about selling vaccines to those who needed them most?
The Government has kept it's agreement with Pfizer confidential. Despite repeated requests, Chris Bishop said Ministers have declined to release any details about how these arrangements were made on the grounds of commercial sensitivity.
However, there have been hints that the decision to move back in the queue was partly out of our hands.
In January, Covid Reponse Minister Chris Hipkins said "New Zealand will be at the front of the queue".
Yet, as we have seen, this hasn't happened. When that became apparent, National Leader Judith Collins said: "New Zealanders were told that they would be at the front of the queue to get vaccines. Turns out we can't even see the queue. That is actually a very serious broken promise."
Then in February, One News political editor Jessica Mutch McKay reported the Prime Minister calling on other countries to not suck up all the vaccines.
The Government has commonly blamed delays on supply constraints, with Pfizer reporting more demand for the vaccines than it could produce. We have seen the effects of that even with our delayed rollout in New Zealand, coming very close to running out of vaccines in June.
Why the Government's critics believe NZ's been let down
For Bishop, he believes the argument that New Zealand is lagging behind because our people weren't dying is a convenient excuse.
"I don't accept that, because if you take the argument to its logical conclusion we wouldn't be rolling out the vaccine at all," Bishop says.
Chris Bishop. Photo credit: One News
"We've eliminated Covid, or had done up until a couple of weeks ago. And you know, by definition, every country in the world needs the vaccine more than we do."
"If they really believe that argument, they'd be giving those vaccines away to other countries who need them more. And you'll notice, of course, that they're not doing that."
In fact, in the eyes of the World Health Organisation, our vaccine plans may actually be too robust.
In June, New Zealand made the decision that we would vaccinate children down to the age of twelve, and perhaps younger if the evidence showed it safe to do so.
At the same time, Director-General World Health Organization Tedros Adhanom Ghebreyesus, was urging countries not to.
"Countries that vaccinate children and other low risk groups now do so at the expense of health workers and high risk groups in other countries."
However, New Zealand has made efforts to help other nations with their vaccination efforts - allocating $75 million to support vaccination schemes in Pacific nations, and donating 1.6 million doses of the AstraZeneca vaccine to Fiji, Papua New Guinea, the Solomon Islands, Timor-Leste, Tonga and Tuvalu.
Although it is unclear if our delayed rollout was our decision or not, Bishop says it's the Government's fault regardless.
"It all goes back to mistakes made in the final quarter of 2020. We were slow to sign our contract, slow to approve the vaccine, slow to order. And of course, that's now having the effects of a slow rollout in 2021."
Despite our success in elimination, we should have made every effort to be at the front of the queue - including paying a premium to receive priority delivery, he says.
"All those lack of decisions are all on the Government. Supply constraints are a problem, but they've been caused by Government inaction."
Too little, too late?
The Government's argument for our vaccine delay is based on the understanding that people in other other countries were dying, and ours weren't.
But, as New Zealand tries to contain the current outbreak with everyone at level 4 restrictions, the incredible spread of Delta through the community has highlighted how vulnerable our unvaccinated society is.
While it took a month to reach 100 cases with the original strain of Covid-19 last year, it took only six days for Delta to produce the same number of cases. As yet, there have been no deaths.
Further, Delta is so contagious that countries previously pursuing the elimination method like New Zealand have abandoned it - like Australia did this week.
In an interview with 9News in Australia on Tuesday 24 August, Australian Prime Minister Scott Morrison said Delta is so infectious that the only way forward is a vaccinated population.
"Any state and territory that thinks that somehow they can protect themselves from COVID with the Delta strain forever, that's just absurd," Morrison said.
"New Zealand can't do that. They were following an elimination strategy. They're in lockdown. The way through is to get to those 70 percent and 80 percent marks [for vaccination] and open safely."
Importantly, the Delta virus also requires much higher levels of vaccination to achieve herd immunity.
Modelling from New Zealand research organisation Te Pūnaha Matatini shows that while we only needed to vaccinate 83 percent of New Zealand to achieve herd immunity against the original strain, a 97 percent vaccination rate is required to defeat Delta.
That means the stakes are much higher than they were 18 months ago, and elimination may not be enough to contain the virus and prevent levels of harm we've avoided in the past.
The good news is that in the midst of an outbreak, the trajectory of our vaccinations is quickly climbing. What's important now is to make sure we finish fast, and overcome the slow start we've had.
Re: also requested interviews with Covid-19 Reponse Minister Chris Hipkins and his deputy minister Dr Ayesha Verrall. Both were unavailable.
New Zealand is the best place to be during Covid, says new report
Fighting Delta: what you need to know about this Covid-19 variant
Why you can still catch Covid while vaccinated


You can now reserve your dog's boarding, grooming, or daycare appointment at Passage East Kennels right here on the internet! The only way booking could get any easier is if you trained your dog to use a computer.
If you are a current customer and DO NOT have access to your online account, please email us & we will send you a message with your login credentials.
Click here to create your account and book!


Emergency Preparedness - Survival Supplies: What is a Solar Tube?
What is a Solar Tube?
You will agree that the technological innovation of solar energy is definitely the coolest. It is now more so with the newest technology that has entered the market. Not many individuals are mindful of the truth that it is to become an ordinary process to fit solar tube skylights in modern homes. You must be thinking "what are solar tubes?" It is fundamentally a modification of skylights making them UV-less and also much brighter. It could be set up very easily in every room or home and it makes use of solar energy.
The solar tube is really a technological innovation that makes use of the lighting of the sun similar to solar panels. It mirrors the lighting into the home. Instead of transforming temperature from sunlight to energy, the solar tube shifts the sunlight to solar cells and also guides it directly into reflective tubes with the help of mirrors as well as other technological innovation for harnessing light that isn't even just in the track of the solar tube with the help of mirrors. This light is going to be led in to the areas.
If you enter a rest room where one of the many solar tubes are installed you might not be able to imagine that the room is not illuminated with a light source powered by the electrical power in the house. Diffuser discs are installed on the openings created in roofs to sift the ultra violet rays and also serve as diffusers of highly powered light that come in. It also guides the lighting in different directions to be able to light up the whole place.
There isn't any involvement of any electronics right here. This Brisbane skylights aid to concentrate natural sunlight in the room. This solar tube skylights are extremely powerful. They will bring in huge amounts of natural light. This technique is innovative on the impression that you will not be required to switch on just one light fixture the whole day, even if the day is gloomy. The light from the solar will not fade the wood finish, rugs and carpets or shade. This light source is very safe. It will bring immense joy and brightness in your home once you set up the solar tube.
Once you put in a solar tube in the kitchen area you won't have to pay for lighting fixtures for the room. If you fit in solar tube Brisbane skylights upon an range of sections on the rooftop you will be able to brighten all the rooms all around your kitchen area as well like the living room, dining room and even the hallways. You won't have to change the foundation in order to put in a solar tube. You only have to have tiny openings inside the ceiling and rooftop and also need a flexible type tube made of aluminium for connecting the daylight that is gathered in your room. Then you're ready to go.
Setting up a solar tube is an economical solution to bring light directly into a room and have the power expenses low. Certain units are designed in a manner that you can shut off or protect the lighting if you're not keen on having the daylight flooding your house the whole day. You've the same alternatives as the conventional lights. It comes in handy if you are watching a movie at home however the bright light is negating the total darkness. In these circumstances you can shut off the solar tube.
Lighting performs an essential part in a room. How a room is lighted determines the entire mood of your room. Comfortable and cozy, bright and clear or romantic and also dimly lit, light is often the defining factor. In order to make an area appealing an effective way is always to maximize all-natural illumination in the room. To achieve this, an effective way is to use the solar tube.


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Home/News/India/Pan India/Not Quitting Congress; BJP Spreading Canards: Pratapsingh Rane
Not Quitting Congress; BJP Spreading Canards: Pratapsingh Rane
Former Goa Chief Minister and veteran Congress leader Pratapsingh Rane on Wednesday categorically denied any plans of quitting the Congress and accused the BJP of spreading canards against him.
Not quitting Congress; BJP spreading canards: Pratapsingh Rane. (photo: twitter)
Panaji: Former Goa Chief Minister and veteran Congress leader Pratapsingh Rane on Wednesday categorically denied any plans of quitting the Congress and accused the BJP of spreading canards against him.
Rane was responding to the contents of a speech made by former Maharashtra Chief Minister and BJP's Goa desk in-charge Devendra Fadnavis, who in a speech on Tuesday had hinted that Rane was likely to quit the Congress and join the BJP in the coming days. Fadnavis made the comment during the formal induction ceremony of former chief minister and now former Congress MLA Ravi Naik into the BJP.
I belong to Indian National Congress and that's it! I've been a part of it for 45 years. I will not leave the party.
-Shri Pratapsingh Rane pic.twitter.com/BllPOLOOc6
— Goa Congress (@INCGoa) December 8, 2021
"The news that is being spread that I am quitting my party is a figment of imagination. These people just want to spread canards. I am not leaving my party," Rane said in a video statement issued on Wednesday.
"I belong to the Congress party for over 45 years. and I do not think that I would ever at this juncture of leaving the Congress party. I belong to the Indian National Congress and that's it," the former Chief Minister also said.
Rane's son, Vishwajit, is currently the Health Minister in the BJP-led coalition government. He resigned as Congress MLA in 2017 to join the BJP. Pratapsingh Rane is the oldest serving legislator in the state assembly, with a 50-year undefeated stint as an MLA from the Poriem assembly constituency in North Goa.
Since the 2017 state Assembly polls, 14 out of the 17 elected Congress MLAs have joined the Bharatiya Janata Party.
BJP Congress Goa Pratapsingh Rane
The court asked the health authorities to conduct a lakh RT-PCR tests every day. It also directed them to provide s… https://t.co/rkCmBa6Xmv


This week was my last week at Cobalt Sky.
I feel sad while writing this article, realising that I am actually leaving.
During my time here, I have gained so many things, knowledge, wonderful memories and friends.
HR guru Robert Levering once concluded that a good company to work for is "the one in which you trust the people you work for, have pride in what you do, and enjoy the people you work with". This quote has precisely summarised how I feel about Cobalt Sky.
When I joined the company four years ago, despite all the excitement, I was worried I might have difficulty learning computer programming and scripting as my academic background had little to do with computers. Then I realised that my concerns were unnecessary because my colleagues came from all kinds of background, many of them had been in my situation when they joined the company as graduates. I therefore received tremendous help from them. For example, I was given a book of handwritten training notes, written by my manager when she joined the company. It was like acquiring a precious martial art script in which years of experience was extracted and summarised. Having kept it and learnt from it for the past four years it is time to pass it on to the next person.
Cobalt Sky is not all about working. I always enjoy our in-house activities. We play music in the office as we are marching into Friday afternoon. Everyone submits a few songs to compile a playlist which is usually long enough for the entire afternoon. As a company tradition, we add Christmas theme songs to the playlist when the Christmas is looming. Once we had a discussion about favourite Christmas songs. When asked the question, being a person from different cultural background, I didn't hesitate before humming out loud "I Gotta Feeling" by The Black Eyed Peas. That song was played all night at the New Year's Eve Party later on. It is not a classic Christmas song per se, it is a fun song, who doesn't expect a good time on the Christmas Eve?
What I enjoy the most is the Cobake® bake-off which has been held three times now. I was fortunate to be the winner of the first Cobake® though I failed to defend my title due to the fierce competition. It all started with some mediocre tasting cupcakes sample we received from a local bakery and we thought we could do better than that. Then the competition started, each week one contestant brought his/her best bake which was tasted and scored by the other contestants. The scoring system also evolved into a Robot Wars battle style that was marked based on Style, Control, Damage and Aggression. The competition was by no means less fierce than the GBBO or Robot Wars. I was a bit stressed out after days of thinking, planning and practising my bake. Having said that, I think it is still the best win-win situation where we get to taste different treats each week and we get some of the best office jokes throughout the competition, check out our official twitter account for more details if you like.
I sincerely enjoyed my time at Cobalt Sky where I was given tremendous support along the way. I will miss you all for the joy we had together. I will learn to enjoy the journey I am about to embark upon. It is hard for me to say Goodbye so I am going to say See You Soon.


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Marty Ray Project
"My Momma always said when I cried as a baby, it sounded like a song...I guess I've been singing ever since."
The Marty Ray Project's smash viral cover of Vanilla Ice's "Ice Ice Baby" nearing 5 million views
Born in Memphis, Tennessee, and raised in Blytheville, Akansas, Marty has a true love and passion for the south. Being from a family of musicians, preachers, singers, and songwriters, it was definitely in his blood from birth. He started writing songs when he was twelve years old and from the first song he knew that songwriting was his destiny-- whether he got paid for it or not. "I won't allow anyone to put me in a box creatively, especially a record label." Growing up with Gospel, R&B, Country, and Blues as his musical guidance, he has been blessed with a unique style of singing and songwriting that stretches the boundaries of cultures.
Through teaching his little brother to follow his dreams and aspirations to become an actor, he soon fell in love with the art himself. He began getting involved with local film productions and going to acting classes strictly out of support for his little brother. He started getting requested for roles in local productions because of his majestic beard. That lead to him finding out that he had a gift for acting as well as songwriting. So, with this new love for acting, he began to get deeper into the craft and started booking more roles in Memphis. He now has a talent agent for acting and books roles all over the country.
Marty tours with his band in between acting gigs and is constantly writing songs. He has now written seven movie scripts, four of which have been produced. He has written, directed, and edited several online projects including his viral parody music video "All About That Beard." Marty loves to make people laugh but he also loves to evoke feelings of love and joy through his works. Join the The Marty Ray Project and support Independent Artists like him all around the world.