text:
Q: Vue filter table items There is such an example in bootstrap-vue: complete-example
But when I choose to filter by name nothing happens.
And I am trying to repeat this example on my vue project. Nothing happens too.
codesandbox
And my items have a status options ("success, "warning", "danger").
I have corresponding buttons.
Question: How to filter items by clicking on the corresponding buttons? And how to filter items by clicking on the checkbox?
codesandbox
P.S: bootstrap-vue 2.0.1, bootstrap 4.3.1, vue 2.6.10

A: Please refer the following codepen. Just add one more checkbox for the Status column.
https://codesandbox.io/s/vue-template-owbfo

redpajama_set_name: RedPajamaStackExchange


text:
Comedian T.J. Miller charged over alleged bomb threat ahead of Philly shows
By Michael Tanenbaum
Arrests Celebrities
Gage Skidmore/Creative Commons
T.J. Miller at the 2015 San Diego Comic Con International in San Diego, California.
Add comedian and former "Silicon Valley" star T.J. Miller to the list of public figures who may not realize that joking about bombs is grounds for an arrest — and maybe some time in the slammer.
Bomb threat forces cancellation of The Roots' SXSW concert
Report: Student who allegedly threatened to shoot up Delco school had 'unusual ideas'
Reports: 90 potential threats investigated in Pa., N.J. since Florida shooting
First it was Green Bay Packers wide receiver Trevor Davis allegedly wise-cracking about explosives in a travel companion's bag. Agents with the Transportation Security Administration didn't find it funny and he was arrested.
On Tuesday, the U.S. Attorney's Office in Connecticut announced charges against Todd J. Miller, best known for his previous role as pothead Erlich Bachman on HBO's "Silicon Valley."
Miller is accused of phoning in a false bomb threat on an Amtrak train on March 18. He was arrested Monday night at LaGuardia Airport in New York and released on a $100,000 bond. The charges carry a maximum imprisonment of five years.
Miller, hours after his release, tweeted about performances set for this weekend at Philadelphia's Helium Comedy Club.
What up Philadelphia. Illadelphia. Me and @CJSullivan_ are about to wreck it this weekend. My girl Cork is on the case, @HeliumComedy is the jam. And peanut butter.
See you there. MOST ALL SHOWS SOLD OUT so get them fixed fast. #roadrunner https://t.co/0YIOzL6wvd
— t.j. miller (@nottjmiller) April 10, 2018
Prosecutors allege that Miller, 36, called a 911 dispatcher in New Jersey and reported that he was on Amtrak Train 2256 traveling from Washington, D.C. to New York City. He allegedly claimed that a female passenger had a bomb in her bag and appeared to be checking it anxiously, with an apparent desire to leave the train without it.
When an investigator phoned Miller in New York, the comedian's description of the woman allegedly changed.
The officer detected a slur in Miller's voice and asked him if he had consumed any alcohol that day, according to prosecutors. Miller allegedly admitted he'd had a glass of red wine. The officer then asked him if he suffered from mental illness.
"No, absolutely not," Miller allegedly replied. "This is the first time I've ever made a call like this before. I am worried for everyone on that train. Someone has to check that lady out."
Investigators later determined that Miller had been aboard Amtrak Train 2258, not 2256. When it arrived in Westport, Connecticut, the train was stopped and evacuated while bomb squads searched for evidence of explosives. Nothing suspicious was found on the train.
An attendant on the train told investigators Miller "appeared intoxicated" when he boarded the train in Washington, according to prosecutors. The attendant said he consumed multiple drinks on the train and was removed in New York due to his intoxication.
Miller had also been involved in what the attendant called "hostile exchanges" with a female passenger in First Class. Investigators interviewed this woman and determined she was not behaving as Miller described and would not have been in his sight line for most of the train ride, unless he had repeatedly checked on her.
Prosecutors allege that Miller was motivated by a grudge against this woman to report a false bomb threat on the train.
Contacted Tuesday afternoon, Helium Comedy Club declined to confirm whether Miller is expected to perform in Philadelphia this weekend.
Michael Tanenbaum
tanenbaum@phillyvoice.com
Read more Arrests Celebrities Philadelphia HBO Actors Trains Silicon Valley Comedy Helium Comedy Club Bomb Threat

redpajama_set_name: RedPajamaCommonCrawl


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UK rates: No change in 2014?
Grant Lewis
With data released last week having shown the unemployment rate in the UK falling to 7.1% in the three months to November, just a tenth of a percentage point above the MPC's forward guidance threshold, an awful lot of rubbish has been said and written about how this highlights the failure of forward guidance in the UK. The Financial Times even went so far as to call the fact that Mark Carney will soon have to ditch the current forward guidance framework "embarrassing".
But that could not be further from the truth - the fact that the MPC is already having to think about what to do after the unemployment rate falls to 7%, rather than the late-2015 date it thought was likely when it first announced its forward guidance framework in August, is both a cause for celebration and at least a partial vindication of forward guidance.
Of course, we will never know for certain what role the introduction of forward guidance played in driving the pretty astonishing pick-up in growth seen since spring 2013 – this was of course a period that coincided with the realisation that the euro area was not about to implode. But that can't explain all of the acceleration in growth – the economic recovery in the euro area has come through much more slowly. It would therefore be churlish to think that Mark Carney's appointment, and the subsequent change in policy emphasis, played no role. Certainly, as the charts below demonstrate, his appointment, and in particular his first appearance in front of the Treasury Committee, at which it became clear that a commitment to keep rates on hold was to be his first move, coincided with the abrupt upturn in the economy's fortunes.
With the unemployment rate now on the brink of hitting 7%, the MPC needs to get its skates on to formulate what it's going to do next. It has already told us, in the minutes of its January meeting, that "members...saw no immediate need to raise Bank Rate even if the 7% unemployment threshold were to be reached in the near future" and that "when the time did come to raise Bank Rate, it would be appropriate to do so only gradually". August's forward guidance has therefore already been extended beyond the 7% threshold. And that evolution towards more general forward guidance, i.e. not based on a single target, looks to be what the MPC will announce when it publishes an assessment of how policy will evolve sub-7%. Certainly, comments from Mark Carney last week talking about a need to look at overall conditions in the labour market and economy more generally indicate that a move to simply lower the unemployment threshold has been ruled out. Expect, therefore, a move to a Fed-style commitment to hold rates low for a considerable time after unemployment reaches 7%. But while the MPC is likely to consider publishing Fed-style forecasts of individual members' forecasts of how they expect Bank Rate to evolve, the relatively small size of the Committee may leave some uneasy about doing so. That may prove an evolution too far for the MPC.
Given this, how long can we expect Bank Rate to remain on hold? Well, there are plenty of reasons to believe that it can be left where it is for a significant period yet. Notwithstanding the recent fast growth, on any number of measures the economy remains weak. It remains smaller than its pre-crisis peak, while unemployment remains relatively high and well above the MPC's estimate of the "medium-term equilibrium rate", which Mark Carney last week said is now likely to be below the 6.5% level previously estimated by the MPC. Investment levels, meanwhile, remain low, while productivity growth has been exceedingly weak. Finally, exceptionally weak wage growth means that real average earnings continue to fall even as inflation has fallen back to target. And even if wage growth does begin to accelerate as the recovery progresses, the weak current level of productivity should mean that there is plenty of scope for firms to raise productivity to keep a lid on price pressures. There therefore seem few, if any, immediate risks to the medium-term outlook for inflation. As such, the likelihood remains that the MPC leaves rates where they currently are right through 2014, moving to tighten only at the start of 2015, by which time we expect the unemployment rate to have fallen to a level where the MPC will start to feel that the recovery is in a position to survive a modest upward move in rates designed as the first step in the removal of highly-accommodative policy. And even then, with Mark Carney last week expressing his belief that even in the medium term interest rates will be below their pre-crisis norms, tightening will happen only very gradually. Low rates look set to be a feature of the UK economy for many years to come.
Mortgage approvals and lending
Source: Datastream and Daiwa Capital Markets Europe Ltd.
Consumer confidence and consumption Source:Datastream and Daiwa Capital Markets Europe Ltd.
Grant Lewis, Head of Research


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The Playlist of our Lives: Music and Mental Health
Music is more than just entertainment to most of us. Music has played a central role in every human culture and civilization since the beginning of documented time. People of all ages, races, and backgrounds have made and listened to music. Humans need a soundtrack for their lives.
But, why? Obviously, it's because we like it. But is there more to it than that?
Music and Mood
Mothers have sung lullabies to their babies across civilizations. People have celebrated great occasions with jubilant singing – and, they have mourned losses with aching melodies.
Today, our wide range of music streaming services makes it possible to pull up any kind of music at any given moment to match your mood or the mood you want to be in.
Soothing playlists exist to help transition into sleep
Upbeat playlists help motivate individuals to exercise
Classical playlists may reduce stress and anxiety
Playlists with strong messages may empower
To be honest, there is a playlist for nearly every emotion and feeling that someone can experience. And, even better, today's streaming services offer the option to create your very own playlist to suit your mood, memories, and any other reason you may have for listening to music.
But music can do so much more than just influence our mood and make us happy. Scientists have researched the effects that music may have on our mental health and have discovered that it impacts our brains and can open up avenues of therapy.
Music stimulates the nucleus accumbens part of our brain, which increases those feelings of happiness and pleasure. Additionally, music reaches our neocortex in the brain and can calm us and reduce impulsivity.
Scientific studies have shown that music can help us in a wide variety of ways, including:
Reduce depressive symptoms
Increase emotional expression
Address loneliness, grief, and loss
Elevate coping skills
Improve emotion and mood regulation
Encourage self-reflection
Reduce stress and tension
Manage pain
Improve memory
Music has been proven to be effective in reducing negative behaviors experienced by individuals challenged by symptoms from the schizophrenic spectrum, psychotic disorders, bipolar disorders, depressive disorders, anxiety disorders, trauma- and stress-related disorders, personality disorders, and substance use disorders.
Music as a Form of Therapy
Shortly after World War II, the practice of music therapy developed and can be applied across the board to anyone hoping to become healthier, both mentally and physically. The American Music Therapy Association defines music therapy as: "Music is used in therapeutic relationships to address physical, emotional, cognitive and social needs of individuals."
Therapy effects of music can be experienced in a variety of ways – and, definitely not just in a therapist's office. Listening can relax us, increase our performance, regulate internal systems (blood pressure and heart rate), and restore memories. Attending live music performances allows us to socially interact and develop communities of people we enjoy being with. Music re-creation can reduce stress and anxiety, create social interaction, and provide outlets for emotions. Songwriting and lyric analysis provide less threatening opportunities for people to express themselves when typical forms of communication may be challenging.
Not Just in the Background
Music is not just in the background of our world. It improves our quality of life, empowers and motivates us, soothes us when we are uneasy or in despair, and it lifts us so that we can be the best version of ourselves. It speaks in ways that words cannot.
Albert Einstein may have said it best: "If I were not a physicist, I would probably be a musician. I often think in music. I live my daydreams in music. I see my life in terms of music."
SEKMHC Offers Playlists through Spotify
Because we understand the profound impacts music has on us, SEKMHC has created a Spotify account with a wide range of playlists for our community. Whether you seek empowerment, self-reflection, encouragement, optimism, or anything else, music has something for you! Check out our Spotify playlists at SEKMHC!
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text:
Cet article donne une Liste des métropoles de l'Ohio aux États-Unis.

Une région (ou aire) métropolitaine aux États-Unis se définit par une approche fonctionnelle et non comme en Europe par une approche historique. Elle consiste en un noyau de comtés urbanisés auquel sont rattachés d'autres comtés contigus sur des critères basés sur le degré d'intégration économique et social (la région métropolitaine prend le nom de la ou des villes les plus importantes incluses dans ce noyau).

Autres regroupements
 Les aires de Cleveland, d'Akron et de Canton-Massillon forment avec quelques autres comtés de l'Ohio le Grand Cleveland :  habitants
 Grand Columbus fédèrent quelques autres cantons de l'Ohio dans une mégapole de  habitants

Notes et références

Ohio
metropole

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WTC VIEW was the first play from The New York International Fringe Festival to make the leap to the big screen in 2005, but playwright Brian Sloan resisted the temptation to fundamentally change the nature of his play by opening it up beyond the one apartment in which it takes place. The metaphor of a man trapped inside his own denial of the trauma he felt when the Twin Towers fell on 9/11 has such perfect resonance with the claustrophobia of a story that takes place entirely in the apartment from which he saw them fall. Eric, played brilliantly by Michael Urie, spends the play ostensibly trying to find a roommate in the days following the attack, but as each prospective roommate inspects the apartment, the film becomes a cross-section of New York's reaction to the tragedy, and Eric's best friend, Josie, becomes the voice of reason as she helplessly tries to make Eric see that he's not as calm as he thinks he is.
The film is based on Sloan's own experience of placing an ad for a roommate just before 9/11, and his surprise when, even as the rubble of the towers was still smoking, getting a plethora of replies from people seeking housing. When I spoke with him by phone on February 28, 2015, it was before the 10-year cast reunion and screening of the 2005 film at theAnthology Screen Archives on March 2, as well as the film's March 3 release on iTunes. Resisting the temptation was one of the things we discussed, as well as his subtle, but effective use of sounds as emotional cues from outside the apartment. We also talked about his own reaction to 9/11, which he himself witnessed from his own nearby apartment, the psychology of trauma on the population of New York, as well as the knee-jerk reaction of the MPAA rating board to films with gay characters, and why he chose to release WTC VIEW unrated.
WTC VIEW is a film about trauma, denial, and the way life went on after 9/11. Michael Urie stars as Eric, who placed an ad for a roommate the day before the World Trade Center towers fell, and is surprised when he receives so many replies from people seeking housing for a variety of reasons. Set entirely in the apartment, Eric's denial of his own issues in the wake of the tragedy intersects with the experiences of the people who come to inspect the apartment, and with the unwelcome, but caring, intervention of his best friend, Josie, who insists that Eric is not as together as he thinks he is. The film co-stars Elizabeth Kapplow, Jeremy Beazlie, Lucas Papelias, Michael Linstroth, Nick Potenzieri, and Jay Gillespie. Sloan directed from his own script, which was based on his play of the same name. It was the first play from the New York International Fringe Festival to be made into a movie.


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No job is too small for Movon. To give you greater peace of mind, all of our movers in Porto are fully insured so you are always protected, wherever you are moving to. We only work with professional moving companies in Porto, so you can have every confidence that your move will go smoothly. We select our local moving companies carefully and we only approve the best. They also have SatNav technology, so you will be able to check where your belongings are all the time on the day of the move.
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text:
Toronto Is The No. 1 City Canadians Want To Move To For Real Estate
Isabelle Khoo
If you thought Toronto's high house prices would prevent people from moving to the city, think again. According to a new survey, Toronto is the most desirable city to move to for real estate.
The survey was conducted by personal finance comparison site Finder. Based on a poll of 1,200 Canadian adults, Finder found that 54 per cent are willing to move to another city to own a home. Although that's a small majority, the stat proves the Canadian dream of homeownership isn't dead after all.
READ: More Homeowners Lured Away From Big Cities Due To Low House Prices
However, it is interesting that Toronto was named the city of choice for relocation, considering its expensive market. Not only is Toronto rent at an all-time high — a one-bedroom now costs $2,290 — but house prices are climbing so drastically that not even the U.S. market can keep up.
Unsurprisingly, it's younger Canadians who are the most willing to move for homeownership. The poll found that 85 per cent of Gen Z adults and 70 per cent of millennials are open to moving. This is a significant portion compared to the 57 per cent of Gen Xers (45-54 year olds) and 26 per cent of those over 65.
READ: New Study Shows How Seniors Impact Canada's House Prices
This is "likely because older Canadians already own their homes or are set in their cities," Finder reports.
A previous analysis by RBC senior economist Robert Hogue supports the survey's findings that young Canadians are willing to relocate.
READ: Millennials Make More Money, But Have More Debt Than Gen Xers
"For every millennial leaving a major Canadian city for more affordable digs in the same province, there are between seven and 12 millennials moving in from another country or province," he wrote in April.
Specifically, these millennials are moving to Toronto because the city is a "magnet for young, mobile talent," he added.
Ten per cent of participants in Finder's survey said they'd happily move to Toronto to buy a home. Halifax and St. Catherines rounded out the top three picks, while Regina ranked as the least popular city to move to for homeownership.
Investing in Toronto real estate is worth it if you have the funds, according to a MoneySense report. However, it's become much harder for Canadians to enter the market. Not only do high prices and regulations like the mortgage stress test make things more difficult, but it also now takes Canadians — specifically younger Canadians — much longer to save for a down payment.
READ: How Does Toronto Real Estate Stack Up To Other Investments?
On average, it takes 13 years for Canadians to come up with 20 per cent of their down payment. This is surprisingly high compared to the five years it used to take back in 1976.
Although this fact can be discouraging, Finder's survey proves homeownership is still on the minds of many Canadians.
Isabelle Khoo is a former editor at Storeys. She's previously worked for big brands like HuffPost Canada and has written about every topic imaginable. From Asian representation to parenting trends to mental health, she's covered it all. When she's not busy chasing a story, you can find her boxing or planning her next travel adventure.


text:
Gdzie jesteś, Amando? () – amerykański film fabularny (dramat kryminalny) z 2007 roku w reżyserii Bena Afflecka (debiut reżyserski), nakręcony na podstawie powieści Dennisa Lehane'a.

Fabuła
Fabuła filmu przedstawia historię poszukiwań zaginionej dziewczynki Amandy prowadzonych przez zatrudnionych przez rodzinę prywatnych detektywów Patricka Kenzie i jego partnerkę Angelę Gennaro.

Obsada
 Casey Affleck − Patrick Kenzie
 Michelle Monaghan − Angela "Angie" Gennaro
 Amy Ryan − Helene McCready
 Morgan Freeman − Jack Doyle
 Ed Harris − Detektyw Remy Broussard
 Robert Wahlberg − Detektyw O'Malley
 Amy Madigan − Beatrice McCready
 Michael K. Williams − Devin
 John Ashton − Poole
 Edi Gathegi − Cheese

Zdjęcia
Zdjęcia do filmu realizowane były na terenach amerykańskich stanów Massachusetts i Kalifornia.

Przypisy

Bibliografia

Amerykańskie adaptacje filmowe
Filmowe adaptacje utworów Dennisa Lehane'a
Amerykańskie dramaty filmowe
Amerykańskie filmy kryminalne
Amerykańskie filmy z 2007 roku
Filmy w reżyserii Bena Afflecka
Filmy wytwórni Miramax Films
Filmy kręcone w Massachusetts
Filmy kręcone w Kalifornii
Pełnometrażowe debiuty reżyserów
Filmy wytwórni The Ladd Company


When Wojtek Granitzki was in his late teens, the revolution happened. People in the village agreed that it was the business of Russians and that, as ever, they could keep it. All the same, it reached their corner of Galitzia under a dust cloud in the shape of lean men on horses, who carried bayonet-topped rifles, and waved pistols, sabres and scimitars. Tied to their saddles were the heads of the swords' one-time owners; White Russian loyalist heads sported blond hair and whiskers, had thin, aristocratic noses, the Tatar heads sprouted dark hair and beards, under broad, peasant noses. Nobody needed to look at the faces of the revolutionary guards to know that all were subject to the will of the revolution. They just had to look at thosee battered faces that bounced off the haunches of horses.
The revolutionaries were led by a commissar, a slight man with a sweeping, silver gaze and a shining pate, a forked beard and a brow permanently furrowed. His men took all the food and cooked it over fires in the street. They set a desk and chair outside a storehouse. Some sprawled and dozed around it. Others sat attentively. It looked uncommonly like a church service, except in the details. One of these was that the village's wooden church was burning at the other end of the street. Another was the body of Father Yuri, which hung, eyeless and tongueless, from the crane under the storehouse's roof.
The commissar sat at the table and began to call the men of the village to him one by one. He sometimes began by saying, 'Do you know what has happened to your Tsar?' Their answers might prompt other questions. What did the man before him think of the revolution? The man might say it was a good thing. He might look down and spit, and say it was an evil thing. He might be asked to justify his statement, and then his answer would guide the commissar. The man might be sent to one side, sat on a corner of the square and watched lazily by the guards, might be sent home. He might be sent into the storehouse.
A minute after the storehouse door closed, a sharp explosion would be heard, never diminishing in its ability to startle. Then the next man would be called. Wojtek was sent for. He told his aunt he'd be back just as soon as he could, then pecked her hastily on both cheeks, managing neither to look at her face nor see the helpless gesture she was making. He shrank the village street with his gangly boy's walk, saw the storehouse loom at him.
'You're a Jew?' the commissar checked.
'No sir,'Wojtek answered, and then was asked his name. He gave it.
'Oh? Tell me how.' The commissar took his watch out.
The commissar snapped his watch shut. He held a hand up, and slowly its fingers folded in and his thumb emerged. It was pointed behind him, to the storehouse. No longer looking at Wojtek, he wrote something laboriously onto a list before him. Wojtek stood and looked from the commissar's bald crown to the storehouse door, struck dumb.
'Please, sir, I assure you that I can do something . . . agrarian.' Wojtek's voice attained an agglutinative squeak, which elicited a vibration of amusement from the commissar's men.
'There are none. You know why?' He had to laugh at Wojtek's shake of the head.
'No engineers. Listen.' The commissar beckoned Wojtek to bend down to him.
'Whose, sir?' Wojtek was astonished, firstly at the man's statement.
'There is no authority but the people's.' For the first time, the commissar looked stern. He pointed up to Father Yuri. A startlingly friendly smile broke across his face.
Wojtek took a look up at Father Yuri. He certainly remembered the priest telling them that God would rescue the Tsar, would save them all, and that the Bolsheviks were in fact headed straight to Hell. It didn't look like it from where Wojtek was standing.
'He lied to you.' The commissar made a fatherly shake of the head. 'He told me he had the eyes of God. He told me he spoke God's language. Well.' He pursed his lips. 'Hmm? Look at him now.' The commissar had his thumb up again, and refused now to catch Wojtek's eye, so there was nothing for it but to walk. Wojtek dragged his feet, but he was walking just the same.
The second thing that had astonished him was his late realisation of the commissar's storehouse logic: any man who addressed him as sir was sent into the storehouse. What a schmuck.
Inside, under a head-high mist of cordite and dust, Wojtek saw the bodies of men sprawled on the floor amid smashed boxes and crates and boards behind which hoarded grain had been piled. The men had broken, bloodied heads, collars stained darkly, shirts, trousers likewise. They had long ceased to be his friends, but he had grown up with some of them and, more importantly, it had always seemed to him, grown apart from them too.
Wojtek stared. The man was short and wiry, had a feral look to him. His teeth were strangely white and even. Wojtek couldn't place his accent. He wondered if he was from the east, or the north, or the south. He had already seen White Russians and Tatars, or their heads, at least. The revolution truly was bringing the peoples of Mother Russia together.
Wojtek heard the words, but they didn't seep in till he felt the weight of the pistol in his hand. It was only metal, he knew, a series of pipes and chambers, a spring, friction, and then percussion.
Wojtek wondered only much later why it hadn't occurred to any of the men on the floor to do what he did next, which was to take two quick strides, raise the gun to the guard's temple, and pull the trigger. The bang faded to a ringing note. It scared him. A puff of smoke stung his nose. Fighting the urge to sneeze, Wojtek saw that he had missed the man's temple. That was the adjustment made by his glasses, he supposed, and the trembling of his hand. He had shot the man in the eye, instead. An alarming fountain of blood, more than Wojtek had ever seen outside a farm, was spurting, over Wojtek's shoulder and onto the floor. Wojtek watched the arc dumbly, and stepped out of his daze and smartly to one side as it diminished, made a streak on the floor then ran down the man's face and front.
More alarming was that the guard was still standing upright. Wojtek looked closely and fearfully from the remaining eye to the outstretched hand.
Fastidiously avoiding the hand, he rummaged in a side pocket of the man's coat, and found rounds for the revolver. His hands were shaking too much to be able to load them into the thing. He put the gun into his own pocket, followed it with a handful of rounds. In the man's other pockets were a wodge of slightly damp banknotes, a few coins, some keys, and a schmatter, a rag of a handkerchief.
Wojtek had been in the storehouse one time, maybe. It belonged to Solomon Shinevsky, an old Jew merchant who had bought and sold fairly to Jew and gentile alike. Old Solomon, polite always to the point of nuisance, had called everybody sir. Wojtek saw him among the remnants of boxes of dry goods stacked up by the far door, presumably for confiscation by the people for their revolution.
He turned back and reached for the guard's cap. He put it on his head. He heard the commissar's voice faintly outside, and then that of a courteous villager, and his work took on a new urgency. He helped the guard out of his coat. Even then the man did not fall over, and Wojtek was mighty puzzled, until he saw that the impact of the bullet had forced the man's head onto a metal spike sticking out of the wooden upright behind him. It was displaying him like a beetle in a museum case.
He shook himself into the coat, and began stuffing his finds back in, the banknotes, the pennies, the keys, the schmatter.
He stepped between the bodies on the floor, and went for the far door of Solomon Shinevsky's storehouse. The yard, as he remembered, gave onto the road. It was empty of men. It was full of more broken crates and torn sacks. A wind was whipping up dead leaves, corn husks, loose shavings and kapok, and for a moment Wojtek thought it was snowing.
Solomon Shinevsky's bicycle leaned against the fence.Wojtek pulled it upright, mounted it, hooked up with a tailwind and sailed off into the afternoon, determining right there and then never to call another man sir.
This story is part of a larger work centring on the character of Wojtek, and tracing his journey from his village in Galicia during the Russian Revolution, through war-torn Europe on various stolen bicycles, to the Paris of the 1920s and eventually to Pennsylvania.
It was published in Ambit magazine in 2011.
The story was illustrated by the eminent Michael Foreman, which is a real honour. He has a long association with Ambit, and is an artist in his own right, very much in demand.


With its patented design, the Airscape prevents flavour-destroying oxygen from entering the chamber. The durable 18-8 restaurant-grade stainless steel prevents stains and odour retention. High gloss and scratch resistant, the Airscape is topped by a clear UV-resistant lid with a built-in one-way valve. Top-shelf dishwasher safe. Please note Black container does not have the Liberty Coffee logo.


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The Feast at Lele
Looking for an evening of food and performances with Polynesian flare? Look no further– The Feast at Lele in Lahaina, Maui will immerse you in ancient Polynesian fare and art! From their five-course meal and their Hawaiian-inspired cocktails, to their journey through Hawai'i, New Zealand, Tahihi, and Samoa through dance and song, your evening overlooking the Pacific Ocean from West Maui (complete with sunset!) will more-than-satisfy all of your senses! Enjoy the performances and dinner from your table as you experience the many facets of Polynesian culture.
Lele, the ancient name for Lahaina, was the place of feasting and entertaining for the royal family of Maui. Your evening will embark on a musical and culinary journey through four Polynesian cultures, all closely linked, yet still unique, to one another. Let's explore an evening at The Feast at Lele!
Our first stop is Hawai'i. The show begins with an oli (chant), mele (song), and hula (dance). Inspiration was brought together from four islands; Hawai'i, O'ahu, Kaua'i, and Maui, to honor the 'aina (land) and Hawaiian ali'i (royalty). With this performance come banana & sweet potato chips, served with a tropical ginger & ogo seaweed salsa and your first course; Pohole Fern, Asparagus, & Heart of Palm Salad, Seared I'a with Mango Sauce, Imu Roasted Kalua Pua'a, and Poi. What is poi, you may ask? Poi is a traditional part of Native Hawaiian cuisine, made from the underground plant stem of the kalo (taro) plant. To make poi, one must mash the cooked stem until it is of a thick and sticky liquid, and then add water until it is of the desired consistency. Poi ranges from liquid to dough-like– whatever your preference!
From Hawai'i, we venture to New Zealand, known to the Maori, its ancient inhabitants, as Aotearoa– meaning Land of the Long White Cloud. Here, dancers will wear moko (facial tattoos), which were used to symbolize genealogy and personal identity, while they perform a war dance that was used to intimidate their enemies. Following this dance, the women perform a dance using poi balls, which are used to imitate the actions and rhythms in nature. The strong oratory skills of Aotearoa will be heard, as well. During this performance, the second course will be served; Rakiraki Salad with Poha Berry Vinaigrette, Harore Kumara, and Miti Hangi.
Our adventure continues in Tahiti, considered by many as the image of Polynesia. The feast advances on; Moa Fafa, E-Iaota (Poisson Cru), and Baked Scallops. With these dishes comes the "sensual swing of the hips and pulsing rhythm of the ancient drums, which combine to create a titillating dance performance" (quoted from The Feast at Lele website). Grass and shell headdresses compliment the movements of the hip and hand. This Tahitian performance embodies lust and romance as the dancers move to the rhythm of the beat.
Finally, our journey culminates in Samoa, where men wear shredded leaf leggings and women wear leaf skirts. Each costume accentuates important aspects of their dance; for the men, their leggings emphasize their movements, and for the women, their skirts highlight their gracefulness. Their dance includes the slapping of legs and feet, and rhythmic clapping of hands. The fire knife dance will finish the night's show, leaving you wanting more. The fourth course brings Grilled Squid, Palusami, and Shrimp, Avocado, & Fresh Fruit, followed by the fifth and final course– DESSERT. Caramel Macadamia Nut Tart, Hawaiian Chocolate Truffles, and Fresh Exotic Tropical Fruit is the dinner's finale.
A show for a romantic evening or a family affair, The Feast at Lele will cater to your desired ambiance, as each party has its own table.
A beach enjoyed by Hawaiian royalty. An evening at The Feast at Lele is waiting for you.
All information was gathered from The Feast at Lele's website.


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"A Dozen Questions about Estonia" is a joint project of the Baltic Film and Media School and the Estonian Institute, introducing Estonia and Estonians through the answers, film clips, blog and language tests, all inspired by the 12 questions about Estonia.
"A Dozen Questions about Estonia" is a format created by the Estonian Institute, which consists of various questions that people interested in Estonia might have. The answers to the questions cover different fields of interest, starting from Estonian geography and nature and finishing with song festivals, history and leisure activities. The text is illustrated by photographs.
The first booklets with the 12 questions were published in 1999 and they received a wider exposure at the EXPO in Hannover in 2000. These publications have been distributed all over the world at different promotional events about Estonia and through Estonian diplomatic missions. As of today, the booklet is one of the most widely spread of its kind about Estonia and has been published in Spanish, Dutch, Hungarian, English, Italian, German, Greek, Welsh, Portuguese, Polish, French, Chinese, Russian, Turkish, Swedish and Finnish.
In addition to the original text of 12 questions the web page also consists of 12 short films made by the students of the Baltic Film and Media School. Although the films are related to the original questions, they do not try to find the answers to the questions, but are rather telling a story of their own. The texts together with the films give an overview with a twist of the different spheres of Estonia and the nature of Estonians.
"Tosin küsimust Eesti kohta" koostööpartnerid ning rahastajad
Based on the films, 12 different language tests have been created. The language tests can be used as a study material for everyone learning Estonian. With the tests one can practice understanding Estonian, constructing sentences and creating texts with full sentences. Each test also has open questions, which require longer answers. These can be used for both speaking and writing exercises.
There is a blog as well, where a foreign student living in Estonia gives an insight on his adventurous life here. An observant viewer may also spot the student in the films, so it's actually possible to make connections with the student's life and the stories of the films.
Estonian Institute Suur-Karja 14, 10140, Tallinn
estinst(at)estinst.ee
(+372) 63 14 355


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Journal of Clinical Pathology and Laboratory Medicine
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Research Article - Journal of Clinical Pathology and Laboratory Medicine (2017) Journal of Clinical Pathology and Laboratory Medicine (Special Issue 1-2017)
Role of C3a in Regulating Thymocyte Infection by HIV-1.
Tomasz Rozmyslowicz1*, Dareus O Conover1, Mariusz Z Ratajczak2, Glen N Gaulton1
1 Department of Pathology and Laboratory Medicine, University of Pennsylvania, Philadelphia, Pennsylvania, USA
2James Graham Brown Cancer Center, University of Louisville, Louisville, Kentucky, USA
*Corresponding Author:
Tomasz Rozmyslowicz
Department of Pathology & Laboratory Medicine University of Pennsylvania, Philadelphia, PA USA
Accepted date: January 25, 2017
Citation: Rozmyslowicz T, Conover DO, Ratajczak MZ, et al. Role of C3a in Regulating Thymocyte Infection by HIV-1. J Clin Path Lab Med. 2017;1(1):1-5
Visit for more related articles at Journal of Clinical Pathology and Laboratory Medicine
The primary physiological role of complement proteins lies in augmenting host defense to microorganisms. Among several cascade products, complement components C3 and C5 are cleaved and activated through proteolytic processing during immune activation following exposure to HIV-1. This reaction generates the small peptide anaphylatoxins C3a and C5a, which bind to G-protein coupled membrane receptors that sensitize the response of human T-lymphocytic cells to multiple cytokines including CXCL12/SDF-1. CXCL12 is an alpha chemokine that binds to the CXCR4 membrane receptor, which also functions as a co-receptor for X4-tropic HIV-1. Given the importance of complement activation in immune function and the bioactive nature of complement cleavage products we investigated here the role of C3a in HIV-1 infection of human thymocytes. Our data illustrate a potential new link between HIV-1 infection and complement activation in which C3a anaphylatoxin may modulate infectivity by reducing the susceptibility of thymocytes to HIV-1 infection.
Thymocytes, HIV-1 infection, Complement, C3a.
The complement system is a crucial element of innate immunity and is involved in several processes related to host-pathogen defense mechanisms including during HIV-1 infection [1,2]. The complement system consists of over 30 soluble and membrane-bound proteins and is activated by three distinct pathways in response to the presence of pathogens [3,4]. In each instance the products of these pathways result in cleavage of complement system components C3 and C5 to yield the small peptides C3a and C5a. C3a and C5a function as anaphylatoxins, binding to G-protein coupled membrane receptors that, among several actions, sensitize the response of human T-lymphocytic cells to XCXL12/SDF-1 [5,6].
Activation of the proinflammatory components of the complement cascade is observed in even well managed HIV infected subjects [7]. These elements serve to augment virus opsonization and cell-mediated lysis of infected cells [1,8]. However, a number of other much less well characterized, and seemingly contradictory effects of complement have also been described. For example, complement activation may augment HIV-1 infectivity. Here it was shown that the interaction between HIV-1 gp41 surface protein and the complement receptor C3R modified viral entry to support intracellular viral spread [9]. Similarly, in vitro studies suggested that the complement activation peptide C5a increased the susceptibility of monocytes and monocyte-derived macrophages to HIV infection by enhancing tumor necrosis factor-alpha (TNF-alpha) and IL-6 secretion from these cells [10].
In contrast, we previously reported that human T-lymphocytic cells secrete multiple chemokines that may auto-protect for HIV- 1 infection and that production of these compounds is greatly reduced during active infection [11]. Along these lines, the α-chemokine CXCL12/SDF-1 binds to the membrane receptor CXCR4, which serves as a major co-receptor for X4 HIV-1, and is known to interfere with X4-tropic HIV-1 infection in several cell populations [12]. In view of the overlapping observations of both chemokine production and complement activation during HIV-1 infection, in the present study we examined the potential direct role of the complement component C3a on HIV- 1 infection in thymocytes, a cell population that is crucial to continued maintenance of the mature peripheral T lymphocyte pool.
Thymic cell Isolation, tissue culture and C3A incubation
As described previously [13], fresh neonatal human thymic tissue was obtained from elective thoracic surgeries of HIV- 1 negative individuals aged 1 day-6 month. Tissue was diced into 3-10 mm fragments, and incubated with 0.1% collagenase (Sigma, St. Louis, MO) and DNAase 10 IU/ml (Sigma) solution in Dulbecco's phosphate-buffered saline (PBS) without calcium chloride and magnesium chloride (GibcoBRL, Gaithersburg, MD) for 2 hours at 37°C. The fragments were subsequently passed through a 100 μm nylon cell strainer (Becton Dickinson, Franklin Lakes, NJ), and washed with ice cold PBS. Mononuclear cells were isolated from whole blood by Ficoll-Paque (Amersham Pharmacia, Uppsala, Sweden), and plated onto 10 cm Biocoat tissue culture plates with collagen cover (BD, Bedford, MA) or directly into Biocoat (collagen cover) 6-well plates. Non-adherent cells (thymocytes) were placed in separate dishes (Falcon 24 well plate) for further culture. After 12 hours incubation in RPMI medium (GibcoBRL) cells were supplemented with 10% to 20% fetal bovine serum (FBS), 2 mM glutamine, 100 IU/ml of penicillin, 100 μg/ml of streptomycin and 0.25 μg/ml of amphotericin B. In some experiments, indicated in Results, cells were incubated with C3a or C3adesArg (1 μg/ml) at either -12 hr, 0 hr or +6 hr relative to HIV-1 addition.
HIV infection and assay
Thymocytes were isolated as described above and plated onto either Falcon 24, 48 or 96 well plates as required for subsequent assay. Cells were maintained for one week in RPMI medium supplemented with 10% FBS and subsequently incubated with X4-tropic HIV-1 viral stocks HXB2 or IIIB (gift of Dr. F. Gonzalez-Scarano, Univ. of Texas) at a concentration of 10 ng/ml. After 12-hour incubation, cells were washed 5 times in PBS solution to remove residual virus and zero time samples were collected. Cells were then re-cultured in the presence of RPMI medium supplemented with 10% FBS for the times indicated in the figures. Samples were then analyzed by p24 ELISA or qRT-PCR to determine infection status. ELISA reactions were performed using the Alliance HIV-1 p24 ELISA kit (PerkinElmer, Boston, MA) as previously described [13,14].
Virus measurement by quantitative real-time polymerase chain reaction (RT-qPCR)
Thymocytes were incubated in vitro with IIIB or HXB2 virus. Purified RNA from these cells was reverse-transcribed with MultiScribe Reverse Transcriptase, oligo (dT), and a random hexamer primer mix (all from Applied Biosystems Life Technologies, CA, USA). Quantitative evaluation of the target gene was then performed by using an ABI Prism 7500 sequence detection system (Applied Biosystems Life Technologies) with Power SYBR Green PCR Master Mix reagent and specific primers-reverse primer (HXB2 positions 622 to 642, 5=-AAAATCTCTAGCAGTGGCGCC-3=) was similar to a previously described primer, and the forward primer (HXB2 positions 523 to 539, 5=-SSCTCAATAAAGCTTGCC-3=) had a position and length similar to that previously described [15]. The PCR cycling conditions were 95 °C (15 s), 40 cycles at 95°C (15 s) and 60°C (1 min). According to melting point analysis, only one PCR product was amplified under these conditions.
Detection of complement receptors by RT-PCR
Total RNA was extracted and purified from cells using the RNeasy Mini kit (Qiagen Inc, Valencia, CA, USA) as previously described [16] after treatment with DNase I (Qiagen Inc.) and reverse-transcribed into cDNA. The sequence- specific primers employed for amplification were as follows: human complement component C3 a receptor-1 (hC3aR1; sense, 5′-agaaagacagccaccac cacg-3′; antisense, 5′-gccgcctggagaaatgaatgatagg-3′); human complement component 5a receptor 1 (hC5AR1; sense, 5′-accttcgatcctcggggagc-3′; antisense, 5′-gcgtacatgttgagcaggat-3′); human C5a receptor-2 (hC5L2; sense, 5′-ggattacagcgacctctcgg-3′; antisense, 5′-gcagagacaaacagcacagc-3′). Samples without template controls and reverse transcriptase were used in each run. All primers were designed using the NCBI/Primer-Blast program, and at least one primer in each pair included an exon-intron boundary. Afterwards, all PCR products were analyzed by 2% agarose gel electrophoresis.
Arithmetic mean and standard deviation from p24 ELISA and qRT-PCR results were performed using Microsoft Excel 2011. Data was analyzed using the Student t-test for paired and unpaired samples. Statistical significance was defined as p<0.05.
Results/Observations
HIV-1 infection of thymocytes
We first studied infection of cultured human thymocytes by the X4 (T-tropic) viruses IIIB and HXB2. Thymocytes were incubated with virus at 10 ng/ml (MOI 0.02) and infection status analyzed by p24 ELISA assay. As shown in Figure 1 for HIV-1 IIIB, virus replicated robustly in thymocytes over a 5 day time course. To assess the impact of C3a peptide on HIV-1 replication, thymocytes were pre-incubated with either C3a or the less active inflammatory C3a cleavage product C3adesArg for 12 hours prior to addition of HIV-1. As also shown in Figure 1, pre-incubation with C3a had a significant inhibitory effect on HIV-1 replication at day 3 and more dramatically so by day 5. In contrast, pre-incubation with C3adesArg had no effect on HIV-1 replication at any time point.
Expression of complement component receptors C3a and C5a on thymocytes
To clarify whether the results presented in the Figure 1 potentially result from the direct action of C3a on thymocytes, we next examined these cells for the presence of both C3a and C5a receptor mRNA (C3aR and C5aR respectively) by RTPCR analysis. Reaction products from the RT-PCR reaction were run an agarose gels and visualized as shown in Figure 2. These results demonstrate that mRNA for both C3aR (555 bp) and C5aR (400 bp) were readily detected in thymocytes.
Figure 1: Effect of C3a on HIV-1 Infection in Thymocytes. Thymocytes were incubated with HIV-1 IIIB in the absence (Null), or presence of either C3a (C3a) or C3adesArg (DA) for 12 hr prior to HIV-1 addition. HIV-1 infection was subsequently measured by p24 ELISA at the indicated times.
Figure 2: Expression of C3aR and C5aR in Thymocytes. The presence of mRNA for C3aR (555bp) and C5aR (400bp) in thymocytes was determined by RT-PCR amplification followed by gel analysis and EtBr staining.
qRT-PCR analysis of acute C3a effects on HIV-1 replication
The potential effects of C3a anaphylatoxin on HIV-1 replication may occur at multiple points along the HIV-1 replication cascade. Results presented in Figure 1 demonstrate that C3a significantly inhibited HIV-1 replication when thymocytes were preincubated with this anaphylatoxin. To clarify the time dependence of this effect we conducted qRT-PCR analysis for virus over a 24 hr time course following the addition of C3a either before (-12 hr), simultaneously with (0 hr), or following (+6 hr) incubation with virus. Given that the less active C3a derivative C3adesArg was shown not to inhibit HIV-1 replication (Figure 1), we used this compound as a control for all incubations. Data presented in Figure 3 demonstrate robust HIV-1 replication (240-245 DNA copies) in thymocytes over 24 hr in the presence of 1 μg/ml C3adesArg (Control). In contrast, and in agreement with results shown in Figure 1, pre-incubation with 1 μg/ml C3a for 12 hr resulted in a statistically significant reduction in HIV-1 replication at each time point measured. The magnitude of this inhibition ranged from 49% at 6 hr to 67% at 24 hr. Similar but less substantive effects were observed when incubation with C3a was intiated coincident with (0 hr) the addition of virus. In this instance replication of virus at 6 hr was inhibited by 19%, while at both 12 hr and 24 hr a 27% inhibition was observed; the latter points being statistically signifcant. Lastly, incubation with C3a at +6 hr after HIV-1 exposure resulted in a mixed effect. The impact ranged from a modest 12% inhibition at 6hr, to a slight increase in HIV-1 replication at 12 hr (9%) and 24 hr (2%). None of these differences were statistically significant from control.
Figure 3: Time dependence of C3a inhibition of HIV-1 infection. Thymocytes were incubated with either C3adesArg (Control), or C3a at the indated times -12 hr, 0 hr or +6hr followed by exposure to HIV-1 HXB2. Levels of virus replication was then determined by quantitative real time PCR analysis of samples at the indicated times (6 hr, 12 hr and 24 hr) after virus addition.
Dissecting the mechanisms of HIV-1 pathogenesis and aligned host defence mechanisms is a dauting task as the central sites of HIV-1 infectivity reside in and disrupt fundamental components of both innate and adaptive immunity. One clear example lies in the binding of HIV-1 to both CD4 molecules and chemokine receptor CXCR4 and CCR5 family members. These membrane proteins serve critical roles in, respectively, the recognition and chemokine driven regulation of immune function. Thus, HIV-1 binding to these elements in itself may profoundly alter the subsequent immune response to HIV-1. In previous works we demonstrated that HIV-1infection triggers marked alterations in the patterns of cytokine production by cells of the hematopoietic lineage and that these cytokines serve to reduce HIV-1 infectivity [13,17,18]. While multiple studies have elucidated the primary effects of HIV-1 within adaptive immunity, far fewer focus on the impact of virus on components of the innate immune repsponse.
As noted above, the complement system plays a central role in innate immunity and yet the impact of HIV-1 infection on complement activation, and in a related fashion the corresponding effects of complement cascade cleavage products on HIV-1 infection and immunity, are poorly understood [1,2]. It is well documented that complement activation contributes to a proinflammatory state in even well controlled HIV infection [7], and that this activation regulates virus clearance through both cell-mediated lysis and enhanced opsonization [1,8]. However, the consequences of complement activation also significantly augment production of C3a and C5a, and these anaphylatoxins have profound proinflammatory effects on immune function [7,19]. C3a and C5a are highly active biopeptides that exert their effects through the G-protein coupled receptors C3aR and C5aR and are known to regulate the production of multiple chemokines [10].
Our studies focused on the anaphylatoxin C3a and its capacity to modify HIV-1 infection. It is well established that C3a binding triggers production of CXCL12/SDF-1, and although CXCL12 may inhibit HIV-1 entry via the CXCR4 co-receptor the effects of C3a binding beyond this effect are not known [20]. In this study we examined the effects of C3a on HIV-1 replication in thymocytes using the well characterized X4-tropic viruses IIIB and HXB2. Thymocytes were chose as target cells as they support X4-tropic HIV-1 replication and are a fundamental precursor to the generation of mature Tcells.
The thymus is the primary site of T-lymphocyte development and selection for MHC [21]. Although a dependence on thymic function for immune maintenance decreases with age, thymic tissue persists in adults and may be reactivated following the depletion of peripheral T cells [22]. T cell maturation in the thymus is regulated by the interaction of thymocytes with nonlymphoid thymic stroma via a multifaceted process, which may be disrupted by infectious agents such as HIV-1 [23,24]. There are two primary pathways by which HIV-1 is believed to affect thymocyte development. The first is direct infection and toxicity within thymocytes. Infection of thymocytes by HIV-1 is well documented and, much like with mature T cell infection, can have profound effects on cell viability and function [25,26]. The second means is through HIV-1 infection of the thymic stroma. Although this process is poorly understood the primary mechanisms are believed to occur through alterations in cytokines and/or stromal adhesion events critical to thymocyte selection and maturation [27-29].
The results presented in the present study demonstrated a clear inhibitory effect of complement component C3a on HIV-1 infection. When added prior to HIV exposure C3a resulted in a 60% reduction in HIV replication over a 5 day period as meaure by p24 ELISA and a 67% reduction by 24hr when measure by qRT-PCR. Our results also suggest that the mechanism of this effect is coupled to alterations in the intial events of HIV- 1 binding and entry in thymocytes. We demonstrated that thymocytes produce C3aR, that the inhibitory effects were not observed with the poorly active C3a dervative C3adesArg, and that the inhibitory effects of C3a additon were maximal when added 12 hr prior to HIV-1 exposure. Inhibition was diminshed when C3a was added coincident with HIV-1 and was absent when added 6 hr post HIV-1 exposure. Whether the impact of C3a on HIV-1 replication occurs by direct membrane effects at entry and/or whether C3a binding induces the production of cytokines, such as CXCL12, that subsequently inhibit HIV-1 binding is the subject of our ongoing studies.
Yu Q, Yu R, and Qin X. The good and evil of complement activation in HIV-1 infection. Cell Mol Immunol. 2010;7:334-40.
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Reca R,Mastellos D,Majka M, et al. Functional receptor for C3a anaphylatoxin is expressed by normal hematopoietic stem/progenitor cells, and C3a enhances their homing-related responses to SDF-1. Blood. 2003;101(10):3784-93.
RossheimEBA, Cunningham TD, Hair PS, et al. Effects of well-controlled HIV infection on complement activation and function. JAIDS. 2016;73(1): 20-6.
Tjomsland V,Ellegård R,Burgener A, et al. Complement opsonization of HIV-1 results in a different intracellular processing pattern and enhanced MHC class I presentation by dendritic cells. Eur J Immunol. 2013;43(6):1470-83.
Stoiber H, Frank I, Spruth M, et al. Inhibition of HIV-1 infection in vitro by monoclonal antibodies to the complement receptor type 3 [CR3]: An accessory role for CR3 during virus entry? Mol Immunol. 1997;34:855-63.
Kacani L,Banki Z,Zwirner J, et al. C5a and C5a (desArg) enhance the susceptibility of monocyte-derived macrophages to HIV infection. J Immunol. 2001; 166: 3410-5.
Rozmyslowicz T, Kijowski J, Conover DO, et al. New T-lymphocytic cell lines for studying cell infectability by HIV. Eur J Haematol. 2001; 67: 142-151.
Arenzana-Seisdedos F. SDF-1/CXCL12: A chemokine in the life cycle of HIV. Front Immunol. 2015;6(256):1-4.
Rozmyslowicz T, Murphy SL, Conover DO, et al. HIV infection inhibits cytokine production in human thymic macrophages.Exp Hematol. 2010; 38[12]: 1157-66.
Rozmyslowicz T, Conover DO. and Gaulton GN. HIV-1 infection of human thymic stromal cells and thymocytes in vitro. HIV/AIDS. Res Treat Open J. 2015;2(4):92-96.
Etienne L,Eymard-Duvernay S,Aghokeng A, et al. Single real-time reverse transcription-PCR assay for detection and quantification of genetically diverse HIV-1, SIVcpz, and SIVgorstrains. J Clin Microbiol. 2013;51(3):787-98.
Abdelbaset-Ismail A,Borkowska-Rzeszotek S,Kubis E, et al. Activation of the complement cascade enhances motility of leukemic cells by downregulating expression of HO-1. Leukemia. 2016;198:1-13.
Majka M,Rozmyslowicz T,Ratajczak J, et al. The limited infectability by R5 HIV of CD34+ cells fromthymus, cord and peripheral blood and bone marrow is explained by their ability to produce b-chemokines.Exp Hematol. 2000;28:1334-42.
Majka M, Rozmyslowicz T,Honczarenko M, et al. Biological significance of the expression of HIV-relatedchemokine coreceptors (CCR5 and CXCR4) and their ligands by human hematopoietic cell lines. Leukemia.2000;14:1821-32.
Moreno-Fernandez ME, Aliberti J, Groeneweg S, et al. A novel role for the receptor of the complement cleavage fragment C5a, C5aR1, in CCR5-mediated entry of HIV into macrophages. AIDS Res Hum Retrovir. 2016;32(4):399-408.
Altenburg JD, Broxmeyer HE, Jin Q. et al. A naturally occurring splice variant of CXCL12/stromal cell-derived factor 1 is a potent human immunodeficiency virus type 1 inhibitor with weak chemotaxis and cell survival activities. J Virol. 2007;81(15):8140-8.
Haynes BF, Martin ME, Kay HH,et al. Early events in human T cell ontogeny. Phenotypiccharacterization and immunohistologic localization of T cell precursors in early human fetal tissues. J ExpMed. 1988;168:1061-80.
Spits H. Development of alphabeta T cells in the human thymus. Nat Rev Immunol. 2002;2:760-2.
Stanley SK, McCune JM,Kaneshima H,et al. Human immunodeficiency virus infection of the human thymus and disruption of the thymic microenvironment in the SCID-hu mouse. J Exp Med. 1993;178:1151-63.
Rosenzweig M, Clark DP, Gaulton GN (1993) AIDS.Selective thymocyte depletion in neonatal HIV-1 thymic infection. 1993;7:1601-1605.
Gaulton GN, Scobie JV, Rosenzweig M. HIV-1 and the thymus. AIDS. 1997;11:403-14.
Su L,Kaneshima H,Bonyhadi M, et al. HIV-1-induced thymocyte depletion is associated with indirectcytopathogenicity and infection of progenitor cells in vivo. Immunity. 1995;2:25-36.
McCune JM. Thymic function in HIV-1 disease. SemImmunol. 1997;9:397-404.
Ho Tsong Fang R, Colantonio AD, Uittenbogaart CH. The role of the thymus in HIVinfection: A10 year perspective. AIDS. 2008;22:171-84.
Gaulton GN. Viral pathogenesis and immunity within the thymus. ImmonolRes. 1998;17:75-82.
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© Photo: REUTERS/Amanda Perobelli
With nothing to hold governments or the UN accountable, protection remains elusive when juxtaposed against the reassurance of neoliberal profit.
For the second consecutive year, Latin America has been established to be the most dangerous region for environmental activists. According to a recent annual report by Global Witness titled "Last Life on Defence", 227 environmental activists and indigenous leaders were killed in 2020, with three out of every four killings occurring in Latin America.
Colombia once again led the statistics in the region with 65 environmental activists murdered, among them indigenous and afro-descent individuals, as well as small scale farmers. In Peru and Brazil, almost three quarters of the murders took place in the Amazon regions of the respective countries, indicating that indigenous populations remain in the crosshairs of attackers. Nicaragua's increase in killings – from 5 in 2019 to 12 in 2020, made the country the most dangerous in the region per capita in terms of environmental activists.
The report notes, "It may sound simplistic, but it's a fact worth considering – the process of climate breakdown is violent, and it manifests not just in violence against the natural world, but against people as well."
Over one third of the documented killings were linked to resource exploitation. This statistic is also reflected in the fact that indigenous activists accounted for over a third of fatalities, as the report notes, "despite only making up 5% of the world's population." The direct targeting of indigenous populations was noted in a 2012 report which stated, "All governments are chasing a dominant development paradigm in which today minorities and indigenous peoples don't really have a place and that is a problem."
For people not to have a place, dispossession is the outcome. The targeting of individual activists is the means through which to intimidate indigenous communities. Indigenous leaders remain a major target due to their presence, which stands as a main opposition to the exploitation of land and resources by governments and corporations.
In April this year, the Escazu Agreement came into force in Latin America. It is the first treaty in the region to deal with the environment and to offer protection for environmental activists. Notably, Chile, Costa Rica and Colombia have not signed the agreement, despite their initial involvement in the negotiation process which led to the agreement's adoption in 2018.
The Escazu Agreement enshrines the provision of access to environmental information, public participation in the environmental decision-making processes, access to justice in environmental matters and the protection of human rights defenders in environmental matters.
Article 9 of the agreement calls upon the signatories "to prevent, investigate and punish attacks, threats or intimidation that human rights defenders in environmental matters may suffer while exercising the rights set out in the present agreement."
However, the provisions set out in the agreement are in contradiction with the exploitative politics embraced in the region. Besides the fact that not all countries are on board – besides Chile, Costa Rica and Colombia, Guatemala, Brazil, Peru and Colombia have not ratified the agreement – the links between governments and multinational corporations take precedence, resulting in widespread impunity when it comes to the political violence employed against both land and indigenous communities.
The Global Witness report calls out the culpability of business and governments in terms of violence, yet its recommendations testify to a recurring cycle that places responsibility to protect on the same entities which engage in exploitative business ventures against environment, activists and indigenous communities. The UN may be treated as distinct from governments, yet its composition brings together the same neoliberal practices which have destroyed land and people. With nothing to hold governments or the UN accountable, protection remains elusive when juxtaposed against the reassurance of neoliberal profit.
October 11, 2021 | World
Brazil Ecology Human Rights Latin America Neoliberalism
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text:
Zaza (bra Zazá) é um filme mudo norte-americano de 1923, do gênero drama romântico, dirigido e produzido por Allan Dwan, e estrelado por Gloria Swanson. É baseado na peça teatral francês de mesmo nome, contracenado em 1899 e estrelado por Mrs. Leslie Carter. Cópias do filme estão conservadas na George Eastman House e na Biblioteca do Congresso.

Uma versão anterior do filme foi lançado pela Paramount em 1915 estrelado por Pauline Frederick. Uma terceira versão, dirigido por George Cukor e estrelado por Claudette Colbert, foi lançado em 1939.

Elenco
Gloria Swanson - Zaza
H. B. Warner - Bernard Dufresne
Ferdinand Gottschalk - Duque de Brissac
Lucille La Verne - Tia Rosa
Mary Thurman - Florianne
Yvonne Hughes - Nathalie, empregada da Zaza
Riley Hatch - Rigault
L. Rogers Lytton - Gerente de palco
Ivan Linow - Apache

Filmes dos Estados Unidos de 1923
Filmes de drama romântico dos Estados Unidos
Filmes ambientados na década de 1890
Filmes ambientados na França
Filmes dirigidos por Allan Dwan
Filmes gravados em Nova Iorque
Filmes da Paramount Pictures
Filmes mudos
Filmes em preto e branco
Filmes baseados em peças de teatro
Filmes de drama romântico da década de 1920
Filmes em língua inglesa
Regravações de filmes


text:
Indigenous chiefs voice concerns with systemic child welfare issues
Ryan White, Digital Producer
@CTVRyanWhite
Published Monday, February 19, 2018 9:39PM MST
Last Updated Monday, February 19, 2018 9:41PM MST
First Nations leaders from Alberta and Saskatchewan gathered on Monday to express their collective dissent for a child welfare system that they say fails Indigenous children.
The meeting on Siksika Nation was prompted by a recent removal of two Indigenous children from their respective bands who were then placed together in protective custody in a non-Indigenous home. An advocate for the family says relatives were willing to accept responsibility for the care of the children but their plea was not heard by family court.
According to the chiefs of the Siksika Nation and the Mosquito-Grizzly Bear's Head – Lean Man Nation, many of the impacted families are not aware of their rights before losing their children and the displaced children are robbed of their culture, heritage and identity.
"The government simply comes in and takes our children away," said Chief Joseph Weasel Child of Siksika Nation. "There is a Blackfoot child who should be here with family on Family Day."
"It's a sad day in Canada when we allow this to happen."
The chiefs say the bands were not informed of the scheduled court proceedings regarding custody until the week before custody was to be awarded.
The leaders are calling on the government to take steps to ensure Indigenous children remain with their cultures.
Bren Little Light, a survivor of the Sixties Scoop, knows all too well the trauma of becoming disconnected from her heritage. "I was still in diapers when I was taken from the reserve." The Sixties Scopp says the government removed First Nations children from their homes and placing them with non-Indigenous families.
"I don't know my language and that really hurts me," said Little Light. "I don't speak Blackfoot and I have just recently learned to powwow dance.'
The custody hearing for the the Blackfoo child and the Cree child is scheduled for Tuesday, February 20.
The Government of Alberta has issued an online plea for additional Indigenous caregivers in an attempt to give children who are unable to stay with their natural families an opportunity to stay in their community.
With files from CTV's Brad MacLeod
Chief Craig Makinaw, Chief Joseph Weasel Child and Chief Daniel Starchief (l to r) address the media during Monday's call for improvements to the child welfare system


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The Vice President positions hold a hugely important place in the administration of the Leeming Spartan Cricket Club, and help to form our Executive Committee, who are tasked with the most significant matters in the Spartan's operations.
As outlined in our Constitution, the Leeming Spartan Cricket Club has two positions of Vice President – with both carrying an equal weight, and represent our second in command.
Listed below are the individuals who have undertaken the vitally significant roles of Vice President, from our first, E. Jefferies in 1920, to our current, Glenn Hack and Paul Kalleske in 2019.
The position of Vice President is a critically important role in the running of the Club, and those elected to the position aid the President in making the Club's most significant decisions.
It is worth noting that up until 2017, the Club had two positions of Vice President known as our 'Senior Vice President' (second in command) and 'Junior Vice President' (third in command). The positions have since been standardised, and carry an equal weighting whereby both members serve as the Club's second in command.
1941/1942 I. McClumpha S. Thomson Final year before recession due to WW2.


The same week that President Donald Trump was meeting with Pope Francis in Rome, another historic event was taking place, as the Global Christian Forum facilitated a groundbreaking encounter with the major global bodies representing most every part of world Christianity.
Thus we began the week of healing as the media broadcast Trump's reality-show drama that cast the climate as some meaningless backdrop for second-rate actors. I passed the time between administering dosages of oxycodone by reading predictions of this staged Rose Garden event. As I read, I wondered: How soon will my daughter heal from this extraction? And what does it mean to extract the second-highest emitter of carbon emissions from an international agreement? And why are these two extractions — on such different scales — linked in my mind forever?
For many Asian immigrants and refugees, coming to the United States wasn't fully voluntary, but a result of war and poverty. Just as the Hebrews needed to learn to live as exiles, Asian Americans needed to find a way to make a new home in a new land. While their hardships reflect the difficulty of exile, Jimmy's and Mary's familial love and corporate responsibility also model for me how we Christians are to follow Jesus in the midst of this empire.
Patty Jenkins on set / courtesy of Warner Bros.
Wonder Woman, directed by Patty Jenkins, now holds the title of biggest box office opening for a female-directed film.
At first glance, the meaning behind this tagline for Wonder Woman feels obvious, it is the next step on the DC franchise road to November's Justice League movie. But of course, there's more to it than that. Wonder Woman marks a feminist milestone, too, one that feels like artistic justice: it's the first major superhero movie to feature a female hero, and the first to use a female director, Patty Jenkins.
How Much Do Civil Rights Really Matter to the Trump Administration?
Social and economic inequities are not just personal attitudes — they are the result of structural problems prevalent in many sectors of society and government. In the face of this reality, the federal government can be a force for good, attempting to correct its own past complicity and working to prevent future discriminatory behavior by businesses, schools, contractors, local police departments, and more. But this administration's disregard for civil rights in the federal agencies it administers leads to an inescapable conclusion.
The pope talks about environmental protections from a spiritual perspective — an understanding of creation as a holy and precious gift from God, to be revered by all. We should make it a priority to keep our air clean, our water pristine, and our land whole. Whether we understand environmental stewardship as a God-given moral responsibility or from an economic and military strategic viewpoint, the fact remains: Environmental instability is inextricably linked to economic instability and increased discord throughout the world.
The biggest issue War Machine faces is that satire seems to be the wrong track for the movie to take. War and soldiers are difficult subjects to make funny. The best that writer-director Michôd can manage is to provide the stars — like Pitt and his military cohort — with a couple of strange quirks to color their performances. Sometimes these characterizations feel lazy, other times like the actors are trying too hard. The humor, when it's there, feels forced.
A young indigenous man from the Quinault Indian Nation was killed on Saturday night by a man witnesses describe as a white, in his 30s, who shouted racial slurs before backing over two men with his pickup truck, reports the Seattle Times. But you probably haven't heard this news, not with all the other news floating through cyberspace.
Pentecost Casts a Vision of Redeemed Humanity. Why Can't We Follow It?
Most often Pentecost comes to us as a momentous Christian occasion of spiritual power, ethnic unity, gender equality, multi-generational comradery, and immigrant hospitality. But when the moment has passed, it gives way to the more ignoble features of life and community, like spiritual apathy, sexism, racial prejudice, ageism, xenophobia, etc.
On Capitol Hill, we find Democrats acknowledge climate change, affirm the need for action, and sometimes even express frustration and discouragement that there has not been more action. It is as if they need more hope. On the other hand, we find Republicans continue to minimize climate change as a problem or maximize the unworkable unaffordability of a solution. Yet sometimes, off camera and behind the scenes, we encounter Republicans who fear calling for climate action due to the risk of being "primary-ed" or knocked out of an election in a primary. It is as if they need more courage.
The heightening militarism following Trump's invitation to Duterte is neither unrelated nor isolated from U.S imperialism in the Philippines — a history that is often manipulated through religious language.
Why did it take clichéd pop verses in English — lyrics that could be copy-and-pasted to any Bieber song and wouldn't feel out of place — and some mediocre Spanish singing for "Despacito" to get its due?
The June 28-July 1 event he calls "a bit of a vacation in a spiritual atmosphere" drew 90,000 when it was last held in 2015 — a predominantly black crowd that also included whites, Hispanics, and people from 40 other countries.
Jakes, an author, media producer, and pastor of The Potter's House talked to Religion News Service about bridging racial and political divides, coping with terrorist threats, and his approaching 60th birthday.
No longer will I be the single woman in my 30s, always a bridesmaid but never a bride. It doesn't mean that I will not struggle to trust God with my life. But it will be a reminder to me — and to all our witnesses — that God does answer prayer, and all the suffering and sorrow that came before can been remade into something more glorious than it was before.
Social media, and Twitter especially, has become a place where people of all beliefs can come together for conversations about all manner of things, from men's rompers to views on abortion. And from our worship leaders and in our pulpits, we hear the word of God for the people of God again, this time in person. So we're constantly processing, constantly asking what God is saying to us, constantly asking who we should be as an institution, as the body of Christ.
But the strong affirmation of Christ's absence kept the early church from centralizing around Jerusalem. Without the body of Jesus to create a memorial, no land or language could monopolize claim to sacredness. Ascension, in one sense, is an abdication of worldly authority. It is the empowerment of everyone, no matter their land and language.
Since hearing the news, I have anguished over one question: Why did white evangelical silence over this unprovoked attack by this white man on the black man bother me so much? Certainly racial attacks against African Americans by white Americans is not a new phenomenon. My answer came in reading the response of the judge where the attacker was held without bond.


Reading the various blogs I do, I tend to read entries or stories about jobs these people have. I have seen such a range of jobs that I figure I would take this weeks Thursday 5 to take a look back and visit five jobs that I've had.
This was my first job in which I didn't last long but I did get my first girlfriend. She was a fellow employee. She asked me out after a movie one night. I never went out with a girl before that night and I sure did the whole giggle thing and just said yes and walked away. Yes, I didn't get her number. Smooth for sure! So time went on, we became boyfriend/girlfriend officially. I was head or heels. Butterflies and all that fun stuff. I got a crash course in relationships in which I failed. In the end, she left me for some other guy in my neighborhood. Not before, stomping out my heart by cheating and being caught on video cheating on me with 8 other guys. Oh and I got fired two days later because I wasn't performing up to their standards.
I worked at a total of 3 different locations within the city. The first one was not even for two weeks. It was located on the corner of Carling Avenue & Broadview. I worked there for 4 months. I got robbed twice then quit. The second one was at the famous corner of merivale & meadowlands. Worked there for almost six months but once I got a offer to be at a location closer to my house, I had to take it. This brings me to final location. Man, it was inside of carlingwood mall. I had a blast until they had to let me go due to not enough hours. My first and only Christmas party, I strolled in, dressed in a white shirt & black pants flanked by 6 women. Everyone called me the donught pimp. I also dirty danced with my boss and the assistant boss. That lead to a new rule being created saying not to dance so x-rated.
This was the job I had all throughout the college years. I was a corporate sales rep. I sold cell phones primarily but I also dabbled in everything from home phone/cable/internet and mobile internet. I was making amazing money for myself but I was losing friends because of my more than aggressive habits when it comes to sales. No one was safe when it came down to it. It was a great job that if I wanted to alienate friends I would do again. The highlight of this job was making my first 4 digit paycheck.
The longest job I've had to date. I work there in two stents for 2 years at least. It was the people that made this place not the job it's self. A list of things that working here got me is shy of daunting. I can say I got so many friends that I still carry with me today. I got a drive to improve myself after making many mistakes. And showing how real friends can be and how fake some can be. The highlight of this job came from the late night trips on payday to Mcdicks. It was a bunch of us people who finished work at midnight every night.
The job started out great. I was working full time hours which I was promised from the start. The first couple of weeks were awesome. I met some great people and my boss was so helpful. I wanted to help the company back. I started working at 3 different locations just keep my 40 hours but soon they started to drop down the hours and book me at all three stores less and less. My hours went wonky as in working 11-7am one day then 3-11pm the next day. My boss knew that with busing those hours aren't possible. I became frustrated about the hours and lack of respect I got from my boss. At the end, I could barely pay rent due to lack of hours. When I left, the letter I wrote to them was just awesome. It was so many backhanded comments.
So those are some of the jobs I've had over the years. They were good and bad. The memories that came from these different jobs I will never forget. What about my current job? Well I can't give specifics due to my agreement I signed. This job is by far the best job I've worked at. I'm two months away from working here a year.
What jobs have you had? Leave a comment telling me about some of your past jobs.
I love hearing what other people have done and the stories that ultimately come along with the good and bad jobs!
I've done all sorts from working in a coffee shop (which I loved) and bars to working in shops to being in a call centre and freelancing in design and photography.
Thanks for the love! And the list of jobs that was there, ya I couldn't do some of them for a living. Bars? Not my scene but hey, everyone is different.
Nice selection! I followed your link on iBlog4.me. Like the mention of being a donut pimp, very funny!
Well thank you for coming over and checking me out!
And thanks! It sure felt like it when I walked into the christmas party.


You want to dress up for an event, you have your suit, shirt, and shoes, but what about the rest? Two dapper gents out of Sydney have set out to help alleviate both the emotional and fiduciary hassle of buying suit accessories.
The Tie Collective has got you covered. With their tie box sets, you get all the accessories you need, perfectly matched together so you do not have to worry about anything but flaunting your dapper wear. We recently spoke to Co-Founder Adam Daniels about the story and the process behind The Tie Collective.
The Tie Collective was birthed out of the plight of the everyday gent trying to simply find and purchase suiting accessories. Their aim is to give the everyday gent a rotation of fashionable accessories without having to worry about the costs or the issue of what matches.
Another issue that many gents face is the need for quality accessories as a cheap tie can even make a nice suit look drab when the tie should be elevating your attire.
Both co-founders Adam and Chris met each other from their days in the Royal Australian Navy. After six years in the navy, I was curious how the skills learnt there transferred into the business world and into the running of The Tie Collective.
"I believe it [the navy] has taught us a lot of valuable lessons, one of which has influenced greatly our reasons for creating the Tie Collective" Adam tells me, "this was grooming. Especially whilst working at sea, we were still required to have impeccable grooming and this had to be achieved often with very little time.
And this is often what separates innovators from the rest, rather than finding the right answer look ahead and take a step into the right direction and find the answer along the way. As a seasoned entrepreneur Adam says that he is "much more likely to dive headfirst and learn by doing, it saves a lot of time and money." Good advice for anyone looking to create something.
Later I questioned Adam on thoughts of suit accessorising. He tells me that you should dress for your occasion and for your mood. For example if you are a loud person wear bright colours, try a reverse puff fold for your pocket square; if you are more conservative find comfort in darker tones, and wear your pocket square in a sophisticated triangle fold.
Adam's go-to attire is a suit, tie, and pocket square, but if going to an event he will implement so more features like a lapel pin. Therefore in Adam's opinion, for day to day wear you do not have to flaunt every possible suit accessory, just go with what the event and the mood dictates, although it is good to have all the options so you can pick and chose.


Drinking & Healing and Red Apron Fine Wines and Spirits are delighted to host the Rhum Clement Master Class on this Thursday – 18th Oct 2018.
Discover the world of Rhum Agriole with Rhum Clement, a brand that pushes traditional boundaries, bragging in flamboyant concoctions with hints of the French Caribbean. In the presence of Rhum Clement ambassador – Mr. Michael Glaize.


Voto Mobiles has launched, its latest model V9 recently. This new VOTO Smartphones represent the Indian youth especially in tier2 & tier3 cities through its combination of dynamic design and power-packed features.
V9 has a mellow body with non-slip design. The back curvy design at its edges gives you a great feeling when your fingers pass over the sides. Grippe texture finish makes the device easy to grip without the fear of it falling out of the hand.
V9 model runs of the latest version of Android Oreo 8.1 powered by Quad Core Processor with memory 3+32 GB, Finger Print Sensor, Face ID Unlock, Google Certified Device (Bug less software), V9 come up with the screen size 5.85" IPS &Display 2.5 curve HD, and Camera 13+2 MP Rear Camera and 8 MP Front Camera with Panorama View Mode.
Sporting a 2.5 Curve HD display, VOTO V9 mobile have power-packed with a 3000mAH battery with clear voice calls in a noisy environment. Mellow body with Non-slip Design with Access to 22 regional languages support. Experience better connectivity with Dual 4G VoLTE+VoLTE, Faster Multitasking & Bigger storage, rich graphics experience and app usage in an uninterrupted form while optimizing the battery life. Besides the powerful sensor and stunning resolution, the high-quality HD display screen gives a spectacular quality view.
VOTO V9 smartphone priced at a range of Rs. 6,999 and is available in all premium retail stores across the country.
"We are excited to mark a new milestone at VOTO with this ultra-modern smartphone V9. VOTO is sure to create buzz and recreate benchmarks in the industry. VOTO has used its expertise to create a unique space having unmatched quality, distribution and pan-Indian service network in the Indian market" said Mr. Santosh Singh, National Sales Head, VOTO India.
Delivering a combination of advanced design and innovative features, VOTO promises a seamless multitasking experience with improved application and web performance.


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