Robert Mealer, M.D., Ph.D., Christopher A. Ross, M.D., Ph.D.
Huntington Disease is a topic covered in the Johns Hopkins Psychiatry Guide.
Huntington disease (HD) is an autosomal dominant neurodegenerative disorder characterized by progressive motor and cognitive dysfunction and, frequently, psychiatric disorders.
There is selective and progressive degeneration of the striatum, as well as atrophy of other brain regions as the disease progresses.
Regional brain atrophy can be detected up to 15 years before diagnosable signs and symptoms are present.
Onset of HD is progressive and insidious; generally occurring in mid-life (~45) though onset can range from infancy to late life.
HD is a triplet repeat disorder, with an expansion of a CAG repeat in the gene "Huntingtin" (HTT) causing an expansion of a polyglutamine tract in the huntingtin protein.
The length of the CAG repeat explains 50-70% of the variance in age of onset (the longer the repeat the earlier the onset), and also influences rate of progression (the longer the repeat, the faster the progression).
HD is a fatal disorder for which there are no disease-modifying therapies.
However, numerous effective symptomatic treatments are available.
Cognitive impairment due to Huntington disease is classified under the neurocognitive disorders (NCDs) section of the Diagnostic and Statistical Manual of Mental Disorders, 5th Edition (DSM-5).
Mealer, Robert, and Christopher A Ross. "Huntington Disease." Johns Hopkins Psychiatry Guide, 2017. Johns Hopkins Guide, www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787115/all/Huntington_Disease.
Mealer R, Ross CA. Huntington Disease. Johns Hopkins Psychiatry Guide. 2017. https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787115/all/Huntington_Disease. Accessed April 23, 2019.
Mealer R, Ross CA. Huntington Disease [Internet]. In: Johns Hopkins Psychiatry Guide. ; 2017. [cited 2019 April 23]. Available from: https://www.hopkinsguides.com/hopkins/view/Johns_Hopkins_Psychiatry_Guide/787115/all/Huntington_Disease.


Wash the rice under cold running water until the water runs clear. Allow to drain and then transfer to a rice cooker. Add 660ml water and leave to cook. Once cooked, spread the sushi rice into a baking dish or tray.
Mix together the rice wine vinegar, sugar and salt. Sprinkle the mixture over the sushi rice and then leave to cool to room temperature.
For the maki rolls: remove any bones from the salmon fillets and then cut each fillet into 6 strips approximately 12cm long and 1.5cm wide. Cut the sun blushed tomatoes into strips.
Chop the chives into small pieces and then mix into the goat's cheese. Season with salt, piment d'Espelette and a drizzle of olive oil. Place the goat's cheese mixture into a piping bag.
Place a nori leaf onto a sushi mat and then add a layer of rice. Add a little wasabi to one edge and then pipe the goat's cheese alongside. Add a few strips of sunblushed tomatoes and then zest a little lime on top. Finish by adding a strip of salmon and then use the sushi mat to roll one long maki. Use a sharp knife to cut the roll into individual maki pieces.
To serve: plate the baby spinach leaves and sprinkle with soy sauce. Add a little olive oil and some picked ginger. Place the maki rolls on top to serve.


At Ashlynn's Gourmet we are always in the place that fits us best, the kitchen, therefore, New Creations are always In The Works! We are constantly researching and developing trend-setting products to bring to your table so that you can impress and indulge without spending your life's pay. Here are some of the creations you can expect to enjoy in the following months….


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Local Discounts — York Electric Cooperative, Inc.
Simply show your card and receive the discount. Access Connections.coop to view the discounts offered by local, regional and national participants, including many pharmacies. Participating businesses interested in being featured in South Carolina Living magazine should contact Joyce Baker at (803) 628-5541.
Visit this web page often for the most current and complete listing of all participating businesses listed below. Also look for updated lists in future issues of South Carolina Living.
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Hours: Monday - Friday 7:30 a.m. until 6 p.m., Saturday - 7:30 a.m. until 5 p.m.
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Hours: Monday - Friday 8 a.m. until 5 p.m.; Service Calls 24/7.
Hours: Monday - Saturday 6 a.m. to 9 p.m. and Sunday 8 a.m. - 2:30 p.m.
Hours: Visit chmuseums.org for directions to and operating hours for each of our four sites. (Museum of York County, Historic Brattonsville, the McCelvey Center and Main Street Children's Museum).
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Offer: First consultation and personal training session is free.
Hours: Monday through Friday - 8 a.m. until 6 p.m., Saturday 8 a.m. until 1 p.m., Emergency: 24/7.
Hours: Monday - Friday 10 a.m. until 6 p.m.
Offer: 10% off any purchase including framed and original art – offer not valid with any other discounts.
Hours: Monday, Wednesday, Thursday and Friday 8:30 a.m. until 5:30 p.m. and 8:30 a.m. until 4:30 p.m. on Saturday.
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Offer: 10% purchase of any gift basket.
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Offer: 20% off Shrubs (Organic Green Up).
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Hours: Lunch 11 a.m. until 2 p.m. Monday - Friday; Store open 8 a.m. - 4 p.m. Monday - Thursday and 8 a.m. - 5 p.m. on Friday.
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Hours: 8 a.m. until 5 p.m.
Hours: Monday - Friday 8 a.m. to 5 p.m.; call for appointment on Saturdays.
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Hours: Monday - Saturday 11 a.m. to 10 p.m.; Sunday 8 a.m. to 10 p.m.
Hours: 10:00 a.m. until 6 p.m.
Offer: 10% discount on projects over $200. Discount does not apply on specials.
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Hours: Monday - Friday 9 a.m. until 6 p.m.
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Offer: Buy one gourmet cupcake and get one free – limit 6.
Hours: Monday 10 a.m. until 3 p.m. ,Tuesday – Friday 9 a.m. until 5 p.m. and Saturday 9 a.m. until 1 p.m.
Offer: 10% off of orders $10 or more - alcohol not included.
Hours: Monday - Thursday 11 a.m. - 10 p.m., Friday & Saturday 11 a.m - 11 p.m. and Sunday 11 a.m. - 9 p.m.
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Hours: Monday - Saturday by appointment only.
Offer: $2 off cut and $5 off chemical service.
Offer: $25 for Neurological Diagnostic Testing with NASA publish technology. Includes consultation.
Visit www.providence-chiropractic.com for more details on technology.
Hours: Monday & Tuesday 8 a.m. - 6 p.m.; Wednesday 8-11 a.m., 3-6p.m.; Thursday 3-6 p.m. & Friday 11 a.m. - 6 p.m.
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Hours: 11 a.m. until 10 p.m.
Offer: Free estimates and 10% off of labor and shingle repairs starting at $50.
Hours: Monday - Friday 7 a.m. to 7 p.m.; emergency repairs available 24 hours a day.
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Hours: 7 a.m. until 2 p.m.
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Hours: Monday - Friday 10 a.m. until 7 p.m. and Saturday 10 a.m. until 3 p.m.
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Hours: Tuesday 11 a.m. - 5 p.m., Wednesday - Friday 11 a.m. - 7 p.m. and Saturday 10 a.m. - 6 p.m.
Offer: Cooperative members receive a 10% discount off standard rates and packages. Does not apply to hotel "Hot Rate" offers. Call 1-866-390-5645 and mention code YORK when booking.
Hours: Reservations office open daily from 8 a.m. until 10 p.m.
Offer: First month $1 with paid second month.
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Hours: M-F 10 a.m. -8 p.m., Saturday 10 a.m. – 6 p.m. and Sunday 1 p.m. – 4 p.m.
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1420 East Alexander Love Hwy.
Hours: Monday - Friday 8 a.m. - 9 p.m. and Saturday 8 a.m. - 5 p.m.


text:
The , more often known simply as , is an encyclopaedia on commerce between Europe and the Far East, Africa, and the Americas. It was published anonymously in Amsterdam in 1770 and attributed to Abbot Guillaume Thomas Raynal. It achieved considerable popularity and went through numerous editions. The third edition, published in Geneva in 1780, was censored in France the following year.

The  filled a public need for knowledge in the Age of Enlightenment, answering questions that preoccupied the minds of those in the late 18th century, around the time of the French Revolution.

Content
Raynal's idea was to write a history of European enterprises in the East Indies and the New World, having observed the influence of the great explorations on European civilisation.

The work first discusses the Portuguese and their oriental colonies, going on to give a history of British and French enterprises, then Spanish, Dutch, and other European powers, in the Orient. Next, it turns its attention to all of the various European conquests, losses,  colonies and commerce in the Americas. European commerce with various coastal regions of Africa is discussed, mainly on slavery and particularly trans-Atlantic slave trade. Finally, there is a series of essays on religion, politics, war, commerce, moral philosophy, belles-lettres, and so on.

Style
The  lacks consistency in its style: Raynal limited himself to collecting articles provided by friends and pieces borrowed from existing published texts, without taking the trouble to rework them.

Authors
Although the book was published anonymously, some authors are known, if only in name.

 According to Melchior Grimm, Denis Diderot contributed a large part of the work. He is certainly one of its main contributors, and it is estimated he wrote between a third and a fifth of the book, especially the parts on philosophical themes.
 The nineteenth chapter, summarising doctrine and drawing conclusions, was by Alexandre Deleyre.
 On subjects concerning commerce, Raynal used the writings of Jacques Paulze, d'Aranda and Manuel de Faria e Sousa.
 On philosophical subjects, in addition to Diderot, he used the writings of Paul Henri Thiry d'Holbach, Jacques-André Naigeon and Jean de Pechméja
 He also used work by Abbé Martin, the medical doctor Dubreuil, Valadier, Jean-François de Saint-Lambert, Joseph-Louis Lagrange and Jacques-André Naigeon.

Proud of his work, Raynal sometimes forgot it was only as good as its contributors made it. This can be seen in the pieces supplied by a Dr Sanchez, the author on Portugal and its possessions in the East and West Indies. Pechméja once found Sébastien-Roch Nicolas de Chamfort reading the : "What have you found?", he asked. "I have just been reading an excellent piece, but it finishes with such an awful turn of phrase" (). "Let me see: you're right. I much think that Raynal writes is nonsense; he has added that phrase, the rest is mine". () When Raynal left Paris, Chamford said  ("He is tired of living with his author").

Reception

The  was a great success. In France, over thirty different editions were published between 1770 and 1787, and over fifty were published abroad. Abridged versions were published called  ("Potted Raynal") and  ("Children's Raynal"). Napoleon Bonaparte proclaimed himself a "willing disciple of Raynal" () and took the book with him on his Egyptian campaign. Toussaint Louverture read the book and was especially inspired by a passage that predicted slave revolution in the West Indies. Horace Walpole wrote to Marie Du Deffand: "It attacks all governments and all religions!" (). Anne Robert Jacques Turgot heavily criticized the book in a letter to André Morellet:

At the time, the  was considered an encyclopaedia of the colonial age and the Bible of anticolonialism in the Age of Enlightenment.

In 1780, Raynal produced the third edition of his , which was characterised by bolder and more violent tirades than the previous two, and under his signature at the bottom of his portrait he added the inscription:  ("In defence of humanity, truth, and freedom").

Louis XVI referred the book to the Parlement de Paris for censorship, and also to the Church. It was banned, and burned by the public hangman on 29 May 1781. Declared a public enemy, Raynal was forced to leave France for Prussia, where he stayed the large part of his exile. He was allowed to return to France in 1787, on condition he did not enter Paris.

Today, scholar Jenny Mander notes that there are mixed feelings and overall confusion as to whether  is an anti-colonialist text since there are so many contradictions within the piece itself. On the one side, Raynal makes many statements that are against the overall inhumanity of Europeans and criticizes their seizing of land that is taken solely for European gain and leaves native people vulnerable. For these reasons, some do consider the text to be anti-colonialist. On the other hand, Raynal and his contributors still find slaves and slave labor as essential to the European economy, and they hold their plans for instant emancipation for all slaves. With so many opposing opinions and several other writers who contributed their perspective, reception today is also clearly quite jumbled.

Editions

Current

Available online
 1770: Histoire philosophique et politique des établissemens & du commerce des européens dans les deux Indes], Amsterdam, [s.n.], 1770, 6 octavo volumes, at
 1773: Atlas portatif pour servir l'intelligence de l'histoire philosophique et politique des établissements et du commerce des Européens dans les deux Indes , Amsterdam, 1773
 1780: Histoire philosophique et politique des établissemens et du commerce des Européens dans les deux Indes, Geneva, J.-L. Pellet, 1780, 4 volumes plus an atlas in quarto, BnF No. FRBNF31182796m
 1783, English translation of the French 3rd edition which was published in 1780: A philosophical and political history of the settlements and trade of the Europeans in the East and West Indies, translated by J. O. Justamond, London, W. Strahan and T. Cadell, 1783, 8 volumes, available (Volume 1, 2, 3, 4, 5, 6, 7, 8) at the Internet Archive.

Further reading
Raynal heavily drew on from several contemporaneous works, including:
 Recherches Philosophiques sur les Américains ("Philosophical Studies of the Americans") by Corneille de Pauw
 L'Homme moral ou, L'homme considéré tant dans l'état de pure nature, que dans la société ("The Moral Man, or, Man Considered in a State of Nature, and in Society") by Pierre-Charles Levesque
 Common Sense by Thomas Paine
 L'Histoire générale des Voyages by Manuel de Faria e Sousa.

Sources

References

External links

 A Philosophical and Political History of the Settlements and Trade of the Europeans in the East and West Indies

French encyclopedias
1770 books
Denis Diderot
Books about imperialism
18th-century encyclopedias

redpajama_set_name: RedPajamaWikipedia


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text:
// Copyright 2020 The Chromium Authors. All rights reserved.
// Use of this source code is governed by a BSD-style license that can be
// found in the LICENSE file.

import 'chrome://resources/cr_elements/cr_button/cr_button.m.js';
import 'chrome://resources/cr_elements/cr_dialog/cr_dialog.m.js';
import '../i18n_setup.js';

import {CrButtonElement} from 'chrome://resources/cr_elements/cr_button/cr_button.m.js';
import {CrDialogElement} from 'chrome://resources/cr_elements/cr_dialog/cr_dialog.m.js';
import {assert} from 'chrome://resources/js/assert.m.js';
import {I18nMixin} from 'chrome://resources/js/i18n_mixin.js';
import {PolymerElement} from 'chrome://resources/polymer/v3_0/polymer/polymer_bundled.min.js';

import {PasswordCheckInteraction, PasswordManagerImpl, PasswordManagerProxy} from './password_manager_proxy.js';
import {getTemplate} from './password_remove_confirmation_dialog.html.js';

export interface SettingsPasswordRemoveConfirmationDialogElement {
  $: {
    dialog: CrDialogElement,
    remove: CrButtonElement,
    text: HTMLElement,
    link: HTMLElement,
  };
}

const SettingsPasswordRemoveConfirmationDialogElementBase =
    I18nMixin(PolymerElement);

export class SettingsPasswordRemoveConfirmationDialogElement extends
    SettingsPasswordRemoveConfirmationDialogElementBase {
  static get is() {
    return 'settings-password-remove-confirmation-dialog';
  }

  static get template() {
    return getTemplate();
  }

  static get properties() {
    return {
      /**
       * The password that is being displayed.
       */
      item: Object,
    };
  }

  item: chrome.passwordsPrivate.InsecureCredential;
  private passwordManager_: PasswordManagerProxy =
      PasswordManagerImpl.getInstance();

  override connectedCallback() {
    super.connectedCallback();

    this.$.dialog.showModal();
  }

  private onRemoveClick_() {
    this.passwordManager_.recordPasswordCheckInteraction(
        PasswordCheckInteraction.REMOVE_PASSWORD);
    this.passwordManager_.removeInsecureCredential(assert(this.item));
    this.$.dialog.close();
  }

  private onCancelClick_() {
    this.$.dialog.close();
  }

  private hasSecureChangePasswordUrl_(): boolean {
    const url = this.item.changePasswordUrl;
    return !!url && (url.startsWith('https://') || url.startsWith('chrome://'));
  }

  /**
   * Returns the remove password description with a linkified change password
   * URL. Requires the change password URL to be present and secure.
   */
  private getRemovePasswordDescriptionHtml_(): string {
    if (!this.hasSecureChangePasswordUrl_()) {
      return '';
    }

    const url = assert(this.item.changePasswordUrl);
    const origin = this.item.formattedOrigin;
    return this.i18nAdvanced(
        'removeCompromisedPasswordConfirmationDescription', {
          substitutions:
              [origin, `<a href='${url}' target='_blank'>${origin}</a>`],
        });
  }

  /**
   * Returns the remove password description as a plain text.
   * Used when the change password URL is not present or insecure.
   */
  private getRemovePasswordDescriptionText_(): string {
    const origin = this.item.formattedOrigin;
    return this.i18n(
        'removeCompromisedPasswordConfirmationDescription', origin, origin);
  }
}

declare global {
  interface HTMLElementTagNameMap {
    'settings-password-remove-confirmation-dialog':
        SettingsPasswordRemoveConfirmationDialogElement,
  }
}
customElements.define(
    SettingsPasswordRemoveConfirmationDialogElement.is,
    SettingsPasswordRemoveConfirmationDialogElement);

redpajama_set_name: RedPajamaGithub


Phola Coaches drivers at Wits University worry about their accommodation following unlawful lock changes.
Drivers of Wits buses came home two weeks ago to find that the locks of their rooms had been changed, but were not provided with the new keys.
The drivers say they have, on several occasions, asked Cornelius Simethi, the depot manager for Phola Coaches, for the keys, without getting a response. They say this has left them confused, and worried that they may be locked out of the rooms.
Wits Vuvuzela reported on March 20 that the drivers, employed by the service provider and not Wits, are living in cramped and unsanitary conditions in staff rooms provided for them on the main campus in Braamfontein. Some drivers said they chose to sleep in their cars rather than in the staff rooms due to the cramped conditions.
There are about 30 drivers who have been allocated only two rooms at the university's staff quarters known as Nkomponi since 2014. They say their grievances about their living conditions have not been attended to by Phola Coaches.
Instead, the drivers say they received eviction threats in February, which they rejected. Senior management then ordered them officially, in writing, to vacate the quarters within 90 days, effective from the beginning of February 2017. "…Our 90-day notice will be ending at the end of April, our 90 days aren't up yet but now they have changed the locks," said one driver who didn't want to be named for fear of victimisation.
The drivers allege that Simethi changed the door locks without authorisation from the university.
The drivers deny that they have not been given keys to the room in the past. They say a single set of keys was given to one of them, but because of constraints surrounding only having access to a single set of keys, the drivers resorted to leaving the rooms unlocked.
Ezekiel Nethononda, a locksmith at Wits, said the university had not received a requisition form for the drivers' rooms locks to be changed.
The matter has been reported to the National Education Health and Allied Workers' Union, which the drivers have recently joined. The drivers and the union say they are monitoring the situation closely to see what next step Phola Coaches takes.


Next time you decide to refresh the interiors of your home office or study room, you can create your own unique cork bulletin boards, instead of buying one or paying a carpenter to make it for you. The materials and supplies required are simple and easy to locate, you can make your bulletin board in any size that meets your needs. What's more, you can make it as plain, as colorful, or embellished as you want! These directions will help you get started.
Prepare the plywood and cork boards. Cut the plywood board as per your requirements using the wood saw, or buy it pre-cut with the desired dimensions from the market. Repeat the same process for the cork board. Make sure the cork surface is smooth and even, else the fabric could get snagged or torn while fixing it to the board.
Cutting the fabric. Cut the fabric with the same measurements as the plywood board, but add an extra 5 inches on each side so that it can be pulled back to the back side of the board and fixed comfortably.
Attaching the cork board. Using glue or a spray adhesive, fix the cork to the board and press it firmly all over the board and allow it to dry out.
Fixing the fabric. Once the glue or adhesive has completely dried out and the cork is firmly attached to the plywood board, spread the fabric over the board surface, stretch it tautly on all four sides and turn the board with the fabric to the other side. Pull in all the sides of the fabric tightly and fix tacks or staple the entire perimeter of the board using a staple gun. Cut out any excess fabric and glue the edges so you don't get messy and unattractive tatters or fringes in the fabric.
Prepare the frame. You can make your own frame from scratch using the miter box saw, or you can buy readymade wood or veneer moldings in the required dimensions to fit the board. If using plain wood, you can also paint in any color, matching with the general décor or wall color of the room where the bulletin board will be hung. Wait for the paint to dry out completely, attach the frame to the board with the help of short brads and hammer them into place with nails. Your bulletin board is now ready to be hung up and used!
Decorative cork boards can be used to help you get organized or even in a classroom. You can certainly experiment with the different materials, colors, shapes and sizes and make your own colorful and attractive-looking bulletin boards.


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Darlene Boschert
My name is Darlene Boschert, but people call me Darlene Boschert. Here is my homepage: Darlene Boschert. I live in United States and work as an RHIA, CPC, CPC-H, CPC-I at Audioeducator.com.
Healthcare Conferences by Healthcare Compliance Experts & Medical Coding Veterans!
Darlene Boschert - RHIA, CPC, CPC-H, CPC-I
Emergency Medicine, Family Practice, Pediatrics, Urgent Care, Internal Medicine, Employee Retirement Income Security Act (ERISA) Appeals
Darlene Boschert, RHIA, CPC, CPC-H, CPC-I has been in the medical field for over 30 years. She is currently working for Altegra Health, formerly known as The Coding Source, as a Senior Coding Specialist and Auditor. She is with them for the past 5 years. She works from home and does some traveling for them when the client does not EHR.
Darlene has served on The National Advisory Board for the American Academy of Professional Coders. She is also on the advisory board for The Coding Institute, BC Advantage, The Coder's Edge and numerous other magazines.
She has previously worked for Ultimate Medical Academy as the Director of their Medical and Billing Program in Clearwater, Florida. She also advanced to Vice President of The Career Institute of Florida for their Medical Division for ten years in Clearwater, Florida. She is the former CEO and President of Words, Inc, a medical billing, coding, transcription, and consulting business from 1984 to 1992, employing more than 45 people and serving over 40 physicians and 10 hospitals in 6 different states. Darlene has also worked as a Practice Administrator for 12 years for an orthopedic practice after she sold her business in 1992
Darlene has been a national consultant and speaker for Medicare, Medicaid, Blue Cross, Aetna and many more. She has also put on local and national seminars for various consulting companies throughout the past 30 years and has been a seminar and workshop presenter for the AAPC, PACHS, AMA, AHIMA, The Coding Institute and BC Advantage, just to name a few.
In 2004, she was awarded the honor of "Faculty Member of the Year" by the Florida Association of Post Secondary Schools and Colleges. She is an approved AAPC Instructor and Proctor for the American Academy of Professional Coders and is also a published author for several books and magazines.
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redpajama_set_name: RedPajamaCommonCrawl


Finding an outlet when you're in the woods is a bit difficult but don't worry about keeping your phone charged up and ready to go with the Candle Charger, the generator made to charge up mobile devices, and bonus, it works inside too.
This simple device consists of a pot like attachment on top of a stand. Fill the pot with water and light a Stower candle (it's a small fuel filled torch) under it. Once you have it set up, just attach your phone or other mobile device via USB and you're all done.
This is a pretty handy device because it does work both in and out of doors so it's not just for camping but also would be pretty handy in emergency kits. Since it's designed to work with USB devices, you can use it for a variety of gadgets such as just lights. Currently it is on sale and you can grab one for $89.99.


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Cuban President Calls for End of Threats against Cuba
President Miguel Diaz-Canel on Saturday called for an end of US threats against Cuba and stressed his country is sovereign, in the face of recent US statements.
On Friday, Juan Gonzalez, President Joe Biden's Senior Adviser for Latin America, ratified the White House's support for destabilizing attempts in Cuba and spoke about new sanctions on Havana if an unconstitutional march called for November 15 was not allowed.
The Cuban president tweeted that the US government finances and organizes the design to modify the Cuban political system, for which it engages every small group or institution that contribute to an initiative against the Revolution.
'The United States wants impunity for its operators in Cuba and threatens to take more measures. What an arrogance and frustration! They will receive a dignified response from our people,' the Cuban president tweeted.
For his part, Foreign Minister Bruno Rodriguez rejected the new US threats against Cuba, which he termed as an act of interference and violation of the United Nations Charter.
It is not the first time that the United States shows its support for demonstrations in Cuba. It is a stance also shared by the Cuban-American extreme right members, based in Florida, United States.
Previously, Bruno Rodriguez had condemned Washington's multidimensional strategy against Havana, which includes economic pressure and financing of those who support this destabilizing agenda.


Managing finance is one of the most important task for any business. Whether you are a freelancer or managing a multi-location enterprise it remains one of the core business functions. It won't be wrong to state that if you can't effectively manage finance you won't succeed in the business. In a tech savvy world you need to adopt tools that help you create invoices and bill your clients efficiently. Here we shall take a look at the 10 best online invoicing tools for 2014.
A market leader in invoicing, this tool is simple and easy to use. Using this one can easily create invoices, manage clients, add products, and manage expenses. Invoicera also helps in time tracking and project management, add staff and people to collaborate on projects. It has a free plan that is ideally suited for freelancers managing up to 3 clients, 10 products and unlimited invoices. This tool is highly customizable and can be integrated with e-commerce stores and ERP solutions.
This tool was developed with the idea of creating invoice without any hassle. The user-friendly dashboard allows you to organize different clients, projects and individual tasks with ease. It also lets you generate detailed reports and also integrate third party sites and tools.
This awesome free to use tool allows you to create invoices in a matter of seconds. You can manage multiple clients and automate the process of creating invoice and get paid online. All payments are processed through a secured gateway with a 256-bit SSL corticated from a trusted brand.
It is a complete web based solution that turns billing and invoicing into a cakewalk. You can use it to send estimates and invoices and also track time and expenses in a project. It completely relieves you from paperwork as you can also accept payments from an unlimited number of clients.
If you want to add artistic touch to your invoice this is the tool for you. It helps you create well-designed invoices that can be directly sent to the clients. Apart from this you can effortlessly track time for projects, it also keeps track of the other crucial factors that affect performance. It can be integrated with several payment gateways including Google Checkout, PayPal, and Authorize.net.
An ideal tool for freelancers and small businesses, its USP lies in its ease of use. Using this you will be able to produce professional looking invoices within a few seconds. It offers you a number of customization options such as colors and logo.
It is a robust tool that combines project management, time tracking and online invoicing into one. It is a complete cloud based solution where you can avail PayG pricing plans. With iOS and Android apps you would be able to create and send invoices to your clients from mobile devices.
As the name suggests it simplifies the invoicing process. It is an open source web based invoicing system that you can easily install in your server or workstation. Using this you can easily track finances and send invoices as PDFs along with dozens of other features.
It is a comprehensive tool that has been designed to simplify project management. Apart from managing timesheets you will be able to generate invoices in a few clicks. It allows easy customization of the invoices which can be exported as PDFs or directly be sent to the clients.
It is very popular with small businesses, entrepreneurs and freelancers. Using it you will be able to create unlimited number of invoices and personalize them with your logo and colors. It also has time tracking and reporting feature. It can be used by multiple users at the same time with all the data being synced.
Mark Wilston is a Content Writer and marketing professional working with Pixelcrayons (a professional web & mobile app development company). He loves to read and write different blogs related to web design and technologies. Contributing in a blog post aids him spreading the words online with a new set of people.
I've tried a few invoicing applications over the years and I have to say that Nutcache beats them all. You get a full-featured web app with no limitations whatsoever and all this for free!
Thanks to list Invoicera in your list. For our users- Invoicera also multi-currency and multi-language support.


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Jamalco Energy and Financial Advisory Services
K&M was hired by a private client to provide a detailed analysis on the viability of Noble Group Holdings Limited using publicly available information or information provided by the Client. K&M research will include market intelligence of the recent restructuring of Noble Group. An understanding of the recent changes in the organization and their shareholders strategy will also be provided.
K&M served as technical and financial consultant to the US Agency for International Development (USAID) and the Center for Privatization of the Government of the Dominican Republic. K&M evaluated the opportunities for and impediments to independent power producers in the Dominican Republic. Incorporating technical, financial, legal, regulatory issues, K&M evaluated private sector options for power generation. This effort resulted in the eventual development of the private power law enacted by the Dominican Republic in 1990.
K&M served as technical and financial consultants to Promigas, S.A. for a private gas pipeline project. The project consisted of a 1,000 km gas pipeline in Colombia and is one of the largest private undertakings in the developing world. Promigas, S.A. planned to build, own, and operate the pipeline. K&M provided overall financial structuring as well as commercial specifications for the project. K&M was responsible for: formulating and optimizing the financial package, interfacing with the World Bank for hard and soft credit facilities, interfacing with export credit agencies, preparing risk matrices, negotiating financial contracts, and evaluating and revising cash flows.
As technical consultants to the US Trade and Development Agency (USTDA), K&M completed a definitional mission study of CORELCA, the electric utility responsible for the Atlantic coast grid in Colombia. K&M conducted an energy loss study of Atlantic coast states including Atlántico, Bolivar, Magdalena, Córdoba and César. This involved an in-depth analysis of CORELCA's bidding procedures and evaluation of their commercial specifications; an identification of equipment requirements, possible follow-on U.S. exports. In addition, K&M completed a comprehensive review of major existing distribution companies (DISCOS) serving CORELCA and recommended management changes to reduce electrical distribution losses. These included power losses that were both technical- and fraud-related. K&M also completed an analysis of the inventory, distribution, mapping system and networks. K&M's evaluation and recommendations resulted in a streamlined program approach which saved the Colombian government and CORELCA the equivalent of several million dollars from distribution losses.
K&M was contracted by the World Bank to evaluate the options and requirements needed to improve the institutional and regulatory framework of the power sector in the Dominican Republic. K&M provided recommendations regarding 1) installation of technical systems, document preparation, formation of project evaluation parameters, and development of an institutional design for a Financing Guarantee Fund, 2) development of new power sector regulatory agency's organizational structure, project evaluation policy, project modeling techniques and policy for private sector participation, 3) bid solicitation and evaluation guidelines for private power projects, and 4) a model RFP for the country's first private power project solicitation.
K&M was engaged by USAID to provide the Government of the Dominican Republic with technical assistance on the institutional design and development of the Directorate for Development and Regulation of the Electric Power Industry (DDRIE). This agency was deemed necessary for the country's development of the over 700 MW of power needed to achieve sustainable social and economic growth. DDRIE's mission was to develop the power sector on a private basis.
K&M's work included assisting DDRIE to: interpret existing legislation and to produce rules and regulations for reform of the power sector; develop its organizational structure; develop an institutional design for the Financing Guarantee Fund; provide training for the DDRIE personnel; and prepare complete set of guidelines and manuals for: accounting, tariffs, project proposal solicitation, evaluation and award, concessions, performance monitoring, operation of private sector participants, and enforcement procedures.
K&M was engaged by the World Bank to support recommendations to the Government of Bolivia for the promotion and co-financing with the private sector in the utilization of natural gas. The proposed projects attempt to increase the value-added of Bolivia's natural gas reserves. K&M reviewed the business economics of the proposed investments and assessed the synergies and risks involved in a portfolio of projects depending on natural gas supply. The analysis served to provide a clear understanding of the business feasibility for private sponsorship of each project, given the long-term conditions of the domestic, Brazilian, regional and world energy markets.
K&M was engaged by USAID to investigate and identify private sector investment initiatives for natural gas-fired private power projects. K&M's work included: assessing business synergies and risks of a potential gas pipeline and electricity generation plant project under a BOO/T scheme, recommending suitable level of return on equity (ROE) for the proposed project, and identifying potential sources of capital for debt and equity financing.
K&M was engaged by US Trade and Development Agency (USTDA) to conduct a desk review of the Generation Expansion Plan prepared by Electricidad de Caracas. The objective of this review was to identify power plants that could be developed or built by US companies.
K&M served as a technical and procurement advisor to the Foreign Buildings Operations Office (FBO) of the U.S. Department of State to identify and classify the Department's worldwide needs for Uninterrupted Power Supply (UPS) equipment. K&M conducted a detailed study of current state of the art UPS systems and identified and established the relevant factors which were used to evaluate the UPS vendor equipment and the parameters required to properly operate all types of State Department equipment requiring UPS power. The results of the study were used to: (1) identify readily available commercial UPS systems which meet DOS requirements, (2) develop and advertise competitive, multi-year UPS requirements Request for Proposals (RFP) acceptable to all DOS Embassy UPS users, and (3) provide a technical basis for evaluation of RFP submissions and award of contract.


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Jason Alexander Defends Seinfeld Finale In Light Of Game Of Thrones Backlash
May. 23. 2019 1:33 AM
The crew of Game of Thrones got some support from someone who is all too familiar with controversial finales. Actor Jason Alexander starred on the highly-acclaimed sitcom Seinfeld as George Constanza. The series ran for nine years, but, sadly, for fans of Seinfeld, part of its enduring legacy is its poorly received series ender.
Interestingly, Game of Thrones' series finale aired almost 21 years to the day that Seinfeld had its last episode. The sitcom's series finale aired on May 14, 1998, while the Game of Thrones finale was, of course, on May 19, 2019. And, there has been one significant change in that time gap: the advent of social media and fans' ability to react publicly to their favorite shows immediately.
Eventually, in the late 1990s, everyone knew that viewers did not like Seinfeld's ending. However, social media did not exist back then, so you can only imagine what the backlash would be like if Seinfeld had its finale in today's world. Backlash can be brutal, as Jason Alexander knows all too well. He is still standing by how Seinfeld went out, though. Here's what he had to say after the Game of Thrones finale:
To be clear, I adored the Seinfeld finale. I just keep getting crap about it from fans. I loved that Jerry/Larry found an organic way to bring back all the amazing guests that enriched our show. It was an amazing week together filming it.
— jason alexander (@IJasonAlexander) May 21, 2019
So, what was all of that controversy about? In case you have no idea, Seinfeld finished its run with the main characters being sentenced to prison terms. Not the happiest of endings for the characters. The fan verdict was swift, and for years, it has been widely considered one of television's worst finales.
Jason Alexander cleared the air about his personal perspective on the end of the NBC sitcom while acknowledging the overall feeling of many fans. After all of these years, they still share their dismay regarding the finale with him. Part of creating something that people feel strongly about is that that passion can sometimes turn to negativity. As for Game of Thrones, time will tell how people end up feeling about it.
Twenty-one years later, Jason Alexander offered his support to the Game of Thrones crew while they are currently enduring the response from fans regarding the show's own controversial ending. It has only been a few days, so it will take time to sort out its legacy in the long-term, but Alexander sent a supportive tweet anyway, which you can read below:
Dear #GOT company, I know a little something about finales and disappointed fans. My advice: live in joy that you are part of something that moves people so. You were all magnificent. My family and I loved it all. Thanks.
This is a lovely message, and I think its sentiment is true. If you felt anything watching Game of Thrones, it clearly did something right. What a fantastic way to say "thank you" for the journey, though. Alexander clearly enjoyed the ride, and what a ride it was.
There is clearly a lot to unpack regarding the Game of Thrones finale. Even before the finale, some fans were expressing outrage over the events of the penultimate episode. In the week leading up to the series finale, Game of Thrones was already embroiled in a backlash. A petition that existed before the penultimate episode took off with intense fervor afterward.
The petition calls for the entire eighth season to be redone. Signatures for it have soared past 1 million and it has gained so much publicity the cast has responded. Game of Thrones' Jacob Anderson, who played Grey Worm, weighed in with a response to it and the events that led to the upset.
It will be interesting to see where fans stand on Game of Thrones' finale in 10 years. Here is me hoping with all of my might that we will have a reunion to look forward to on HBO around then.
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Removing messages on Facebook is a bit difficult and also difficult, it is not such as erasing messages from your email address which you can do with very easy. Or else, Facebook maintains your messages in between you (sender) and also the recipient. Meanwhile, if you wish to erase all Facebook messages in a single click you are at the right place - Delete All Messages Facebook.
Facebook means to maintain your conversation history in Messages as well as Facebook Chat undamaged. This is one point I enjoy regarding Facebook, they understand and enjoy ways to maintain conversation.
Deleting messages from Facebook requires you do it on each conversation, that is why I said previously that it is a little bit tough and also challenging to erase all Facebook messages on your inbox on a single click.
On this exact same post, I shall discuss with you regarding approach to remove all Facebook messages at once. As we all recognize that messages are exclusive section and also is extremely sensitive location on Facebook.
We share most of day-to-day regimens functions, practices as well as share out individual images, passwords or several various other points which we can handle to share publicly or privately as its need from us, depending upon whom the messages is to be provided.
Even Lovers take pleasure in to talk on Facebook but in some problem we are in serious problem and we don't have time to erase all Facebook messages individually.
To remove all conversion it takes significant time. If we have lots of friends that we had Chat with, then it becomes most challenging and hard to erase all messages on Facebook.
So you need not to worry, right here we are mosting likely to discuss in details the method you will certainly make use of to have your inbox got rid of at a single click. Please do me a favour, hum, keep reading as you comply with the technique.
This technique or strategy is, but you require the following to delete every inbox message on a solitary click.
- To start with we all should install extension into our web browser.
- To remove full Facebook chat messages with all of your friends in one single click, install an add-on or activity on Chrome called Facebook Fast Delete Messages expansion.
- Download them inning accordance with your internet browser where you wish to utilize.
- After installing any one of the above given expansion currently continue for more instructions.
When set up, the extension is triggered automatically. Now to erase your Facebook messages with only one click without needing to open the specific conversation pages open your Facebook Message web page. Here are the steps.
Action 1: Log in right into your account.
If you really intend to do anything, or make any type of change in all on your account, firstly you should access your Facebook account by offering your information on the call for area.
Step 2: Click your Facebook message web page.
It is time to access your Facebook message web page in other to erase all Facebook messages at once.
As quickly as you logged into your account, click on the message symbol to access your messages.
Then you will see two extra switches, one on top bar and also an additional highlighted in red.
Click these switches to completely delete your messages and also discussions.
Finally on removing all Facebook messages in one click.
Finally, we hope you appreciate this outstanding way to erase all Facebook messages simultaneously. Remember to share it with others. For any assistance, feel free to comment below.


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Life in Polish Cities During the Second World War
November 2, 2019 November 2, 2019 / donnagawell
In late September 1939, the deafening roar of war was replaced with ominous silence on the streets of Warsaw. The survivors emerged from their cellars and other hiding places and glanced upward, expecting the hail of bombs and shells to resume their terrible destruction. It was a terrifying scene of utter destruction and tragedy.
Warsaw, like most Polish cities, had been cut off from the outside world since September 1. Rumors of surrender were whispered about, and the possibility was terrifying. Soon, the dreadful truth was revealed, and many officers committed suicide when it was clear the people were bitter with the military and now former government.
German soldiers marched into Warsaw on September 30, 1939, and were soon in complete control. Immediately, work began on removing debris and barricades, extricating corpses from beneath the ruined buildings, and removing the hundreds of dead horses lying in the streets. Restoring transportation, power, gas, and water were the top priorities.
Soup Kitchen in Warsaw
Food supply was the most immediate and difficult problem, and at first, army field kitchens were used to feed the population. While the presence of the Germans was depressing to the Poles, these two weeks before Himmler's men took control was relatively peaceful.
The bloody reign at the hands of the Gestapo began in mid-October, 1939. A terror campaign was launched with the removal of the Polish leadership and elites and to beat the population into submission. Round-ups, executions with no trial, confiscation of property and homes kept the Polish people in a state of fear and mental torture.
Thaddeus Chylinski, America's vice-consul stationed in Warsaw, wrote an extensive report for the US Government in 1941 when he was forced to return home. The report has since been declassified by the CIA and is available in the book "Poland Under Nazi Rule: 1939-1941" where he describes the situation in Warsaw in incredible detail.
In his report, Chylinski explains the situation of the three social-economic groups: the Elite or Cultured Class, the Working Class, and the Peasant Class.
The Elites were at first arrested on mass, but the Gestapo eventually picked up the intelligentsia who had evaded their dragnets in a more methodical manner. Chylinski describes this class of Poles to have been the most persecuted as the German's goal was to quickly annihilate them. Those who survived had great difficulty finding work and were reduced to employment far below their skills and education. Even these positions were hard to come by as the educated elites had to compete with skilled laborers. The supply of labor far exceeded the demand, and therefore everyone's wages were significantly reduced.
Physical laborers in Warsaw were in a better position to eke out a living as they were more adaptable to living in difficult conditions. Still, their situation bordered on extreme poverty. Thousands of specialized workers were taken into the Reich and worked in armaments plants. The gradual elimination of the Jewish population opened opportunities for many gentiles in the cities and towns.
During the early months of the war, the peasant population was treated with greater tolerance than the people in the cities. The city dwellers were desperate for food supplies and would pay exorbitant prices from the farmers.
The peasants' situation changed by the spring of 1940 when Germans "invited" the peasants to work on farms in the Reich. The recruits were negligible, so the Germans took them by force at night with the assistance of the Volksdeutsch village headmen. Anyone resembling a peasant was in danger of being arrested if encountered on the road or on trains.
Soon after the occupation began, the Germans placed quotas on the peasant farmers. All livestock had to be registered, and the village was collectively responsible for the delivery of its farm products. Terrorized farmers were even forced to purchase eggs on the black market if their chickens didn't live up to the Germans' commands. The crafty villagers sometimes managed to circumvent the rules but did so at the risk of death. The unauthorized slaughter of a pig resulted in a bullet to the head.
Chylinski describes the once cosmopolitan city of Warsaw during the first two years of the war as extremely depressed. Army and Gestapo motor vehicles comprised ninety percent of the street traffic. The Polish population walked or used the sprinkling of trolleys, bicycles, or rickshaws.
The majority of the Polish population was shabbily dressed. A well-dressed man stood out and regarded as suspicious. New or used clothing was typically available only on the Black Market, and was incredibly expensive. A man's shirt from the black market was 100 to 150 zlotys and oxford shoes were 800 zlotys.
Warsaw was utterly transformed from the September bombing in 1939. Every church had suffered damage from the bombing, strafing from Nazi machine runners, and others were badly burned. Services in the churches continued, but many of the leading priests had been arrested and put through intensive "neutralizing" before their release. Some were sent to concentration camps or killed in the Katyn massacre.
Most of the larger stores on the main streets were taken over by German firms selling new or confiscated items only to Germans. All sports clubs were taken over for use only by the Reich.
Chylinski's report is now available in print and as an e-book. He wrote this extensive report on the situation in Poland during WWII under the Nazi Regime. Chylinski was the American Vice-Consul serving in the Warsaw office from 1920-1941. This report has been declassified by the CIA under the Nazi War Crimes Disclosure Act.
This report provides historians with an objective report of important topics: The early history of the war, various terrors (arrests, executions, hostages, conditions in the concentration camps, protests, confiscation of property.) Chylinski also reported on the condition of the people from the three social classes (cultured, working and peasant), and the minorities (Jews, Russians, French, Americans, etc.). Economic Conditions are detailed: fuel, food, clothing, relief, and medical supplies. The Industries functioning in Germany are listed: communication and transportation (railways, postal system, and telegraph) as are the authorities of the General Government, the Gestapo, and the Polish Police Force. The situation in education, science, art, and the press is detailed, as is the status of the Polish Underground Movement. Many other details are included.
The reader will appreciate the historical accuracy of the reporter who is unbiased and factual. Chylinski obviously had developed many contacts over his twenty years of public service during the inter-war period in Poland. This book is a valuable addition to the history of WWII and the Holocaust.
Link to Poland Under Nazi Rule 1939-1941 on Amazon:
http://www.amazon.com/dp/B07MB88YSN
Donna Gawell is the author of "War and Resistance in the Wilderness: A Novel of WWII Poland" and "Travel Back to Your Polish Roots" both available on Amazon.
Amazon, european genealogy, Poland, Polish genealogy, World War II, World War II in Poland
German Occupation, Poland, Poland Under Nazi Rule, Polish history, Thaddeus Chylinski, Warsaw, WWII
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Win a Trip to LA and NYC in THOR: RAGNAROK Superpower of STEM Challenge
– August 25, 2017Posted in: Entertainment, Film and DVD
THOR: RAGNAROK follows the tradition of the past few Marvel Studios films, and seeks to inspire young girls to share their excitment about science and technology. From now until September 23, 2017, high school girls (ages 15 – 18) can enter the Superpower of STEM Challenge. The grand prize in the Superpower of STEM Challenge is a trip to Los Angeles for the world premiere of Marvel Studios' THOR: RAGNAROK, an immersive three-day mentorship in New York City with Walt Disney Imagineering, the opportunity to appear on Good Morning America, and more. Check out the video below for more information and continue reading for the link to enter.
From Walt Disney Studios Press Release
Disney, Marvel Studios, Dolby Laboratories, Synchrony Bank, American Association for the Advancement of Science, Broadcom MASTERS and Society for Science & the Public are pleased to present the nationwide MARVEL STUDIOS' THOR: RAGNAROK SUPERPOWER OF STEM CHALLENGE in conjunction with the November 3, 2017 theatrical release of Marvel Studios' Thor: Ragnarok, starring Chris Hemsworth, Tom Hiddleston, Cate Blanchett, Idris Elba, Jeff Goldblum, Tessa Thompson, Karl Urban, Mark Ruffalo and Anthony Hopkins.
Thor: Ragnarok concept artwork, courtesy Marvel
In Marvel Studios' "Thor: Ragnarok," Thor is imprisoned on the other side of the universe without his mighty hammer and finds himself in a race against time to get back to Asgard to stop Ragnarok—the destruction of his homeworld and the end of Asgardian civilization—at the hands of an all-powerful new threat, the ruthless Hela. But first he must survive a deadly gladiatorial contest that pits him against his former ally and fellow Avenger—the Incredible Hulk!
Marvel Studios is, once again, encouraging young girls to explore the superpower of STEM (Science, Technology, Engineering, and Math) with the MARVEL STUDIOS' THOR: RAGNAROK SUPERPOWER OF STEM CHALLENGE.
This program, supported by American Association for the Advancement of Science, Broadcom MASTERS, and Society for Science & the Public, seeks to inspire young girls to use the superpower of STEM to help their family, community or the world be safer, healthier or happier. MARVEL STUDIOS' THOR: RAGNAROK SUPERPOWER OF STEM CHALLENGE invites girls nationwide, ages 15 -18 in grades 10 – 12 living in the 50 United States and D.C., to use the superpower of STEM to create an original Do-It-Yourself project that can be replicated by others.
Five finalists will be selected to come to Los Angeles and present their projects, in person, to a panel of experts and to attend the Red Carpet Premiere of Marvel Studios' THOR: RAGNAROK. Each finalists will receive: Two round-trip tickets to Southern California for the finalist and her parent or guardian, including scheduled meals, ground transportation to and from organized activities, hotel accommodations, from October 8 through October 11, 2017; the opportunity to be on the red carpet at the Premiere of Marvel Studios' THOR: RAGNAROK, $500 deposited into a high-yield savings account from Synchrony Bank; a tour of the Walt Disney Studios in Burbank, California; and more.
One grand-prize winner will be selected from the five finalists to attend an immersive three-day mentorship in New York City with Disney Imagineering to build her STEM story, creating a professional-level video teaching other young people how to recreate her Challenge-winning project. The winner will also have the opportunity to demonstrate her Superpower of STEM project live to the nation with a brief appearance on Good Morning America. (The Walt Disney Company is the parent company of Good Morning America / ABC News.) The video created during her mentorship will be made available to students, teachers and families worldwide on the American Association for the Advancement of Science education resource website ScienceNetLinks.com.
Best of luck to all those who enter, and if you do enter, please come back and share your STEM project in the comments below. For more family friendly entertainment news, be sure to follow Adventures by Daddy on twitter and "like" our facebook page too.
Tags: Anthony Hopkins, Cate Blanchett, Chris Hemsworth, Good Morning America, Idris Elba, Jeff Goldblum, Karl Urban, Los Angeles, Mark Ruffalo, Marvel, Marvel Studios, New York City, STEM, Tessa Thompson, Thor, Thor: Ragnarok, Tom Hiddleston, Walt Disney Studios


text:
Distribution-Based Clustering: Using Ecology To Refine the Operational Taxonomic Unit
Sarah P. Preheim, Allison R. Perrotta, Antonio M. Martin-Platero, Anika Gupta, Eric J. Alm
Sarah P. Preheim
Department of Biological Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Allison R. Perrotta
Department of Civil and Environmental Engineering, Massachusetts Institute of Technology, Cambridge, Massachusetts, USA
Antonio M. Martin-Platero
Anika Gupta
Eric J. Alm
16S rRNA sequencing, commonly used to survey microbial communities, begins by grouping individual reads into operational taxonomic units (OTUs). There are two major challenges in calling OTUs: identifying bacterial population boundaries and differentiating true diversity from sequencing errors. Current approaches to identifying taxonomic groups or eliminating sequencing errors rely on sequence data alone, but both of these activities could be informed by the distribution of sequences across samples. Here, we show that using the distribution of sequences across samples can help identify population boundaries even in noisy sequence data. The logic underlying our approach is that bacteria in different populations will often be highly correlated in their abundance across different samples. Conversely, 16S rRNA sequences derived from the same population, whether slightly different copies in the same organism, variation of the 16S rRNA gene within a population, or sequences generated randomly in error, will have the same underlying distribution across sampled environments. We present a simple OTU-calling algorithm (distribution-based clustering) that uses both genetic distance and the distribution of sequences across samples and demonstrate that it is more accurate than other methods at grouping reads into OTUs in a mock community. Distribution-based clustering also performs well on environmental samples: it is sensitive enough to differentiate between OTUs that differ by a single base pair yet predicts fewer overall OTUs than most other methods. The program can decrease the total number of OTUs with redundant information and improve the power of many downstream analyses to describe biologically relevant trends.
Received 31 January 2013.
Accepted 9 August 2013.
Accepted manuscript posted online 23 August 2013.
Supplemental material for this article may be found at http://dx.doi.org/10.1128/AEM.00342-13.
Copyright © 2013, American Society for Microbiology. All Rights Reserved.
Applied and Environmental Microbiology Oct 2013, 79 (21) 6593-6603; DOI: 10.1128/AEM.00342-13
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For information or any room booking enquiries, including weddings or parties, please email the bookings team: communitycentres@slough.gov.uk or call 01753 875762 from Monday to Friday between 9:30am and 4:30pm. Our bookings team will be happy to discuss your requirements for layout, refreshments and technology in the space.
For any further room booking enquiries, please email the bookings team: communitycentres@slough.gov.uk or call 01753 875762 from Monday to Friday between 9:30am and 4:30pm. Our bookings team will be happy to discuss your requirements for layout, refreshments and technology in the space.
charges are applied for IT equipment, stage and sound system facility.
Other parking is not available on site but car parks such as at the Queensmere shopping centre or Herschel car park are within walking distance.
There are designated disabled parking space nearby: on the High Street, outside MyCouncil and High Street West (opposite where the old library used to be). Unlimited parking is permitted in Pay & Display bays. Please display your valid disabled blue badge clearly to avoid a Penalty Charge Notice.


Find out how to add pictures to your website with the free expression web editorexpression web tutorial: how to design a website with microsoft expression web by christopher heng, thesitewizard.
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text:
Cette page contient les pages d'homonymie de Hulot et Hullot.

Patronyme

 Anatole Hulot (1811-1891), fonctionnaire français à l'origine des premiers timbres-poste ;
 Étienne Hulot (1857-1918), géographe français ;
 Étienne Hulot (1774-1850), général français ;
 Frédéric Hulot (19??-), historien et romancier français ;
 Guillaume Hulot (1652-1722), sculpteur baroque français ;
 Henri Hulot (1732-1775), docteur en droit français ;
 Jacques Louis Hulot (1773-1843), général français ;
 Jean Hulot (1871-1959), architecte français ;
 Léopold Hulot (1923-1948), militaire français ;
 Nicolas Hulot (1955-), écologiste, présentateur et homme politique français.

 Jean-Marie Hullot (1954-2019), informaticien français.
Hulot de Collart est un nom de famille notamment porté par :

 Jean Gaspard Hulot de Collart (1780-1854), militaire français.
Hulot d'Osery est un nom de famille notamment porté par :

 Étienne Hulot d'Osery (1783-1852), baron d'Empire, comte et militaire français ;
 Jean-Baptiste-Etienne Constant Hulot d'Osery (1821-1878), contre-amiral français.

Personnage de fiction

 Baron Hulot d'Ervy, personnage d'Honoré de Balzac ;
 Baronne Hulot d'Ervy, personnage d'Honoré de Balzac ;
 Maréchal Hulot, personnage des Chouans et de La Cousine Bette d'Honoré de Balzac ;
 Monsieur Hulot, personnage de Jacques Tati ;
 Victorin Hulot d'Ervy, personnage d'Honoré de Balzac.


text:
Jack Dann
Biograafia Bibliograafia
Starhiker (1977)
Junction (1981)
The Man Who Melted (1984)
High Steel (1993)
The Memory Cathedral: A Secret History of Leonardo da Vinci (1995)
Bad Medicine (2000)
The Dream Lions (1976)
The Islands of Time (1977)
Echoes of Thunder (1991)
Thunder-Being (1993)
Da Vinci Rising (1995)
The Diamond Pit (2001)
The Economy of Light (2008)
Traps (1970)
Dark, Dark, the Dead Star (1970)
Listen, Love (1971)
I`m with You in Rockland (1972)
The Drum Lollipop (1972)
Whirl Cage (1972)
Rags (1973)
Fragmentary Blue (1973)
The Marks of Painted Teeth (1973)
Od (1973)
The Flower That Missed the Morning (1974)
Thirty-Three and One-Third (1974)
Timetipping (1975)
The Dybbuk Dolls (1975)
Faces Forward (1975)
Yellowhead (1976)
Limits (1976)
Among the Mountains (1977)
A Quiet Revolution for Death (1978)
Days of Stone (1979)
Night Visions (1979)
Touring (1981)
A Change in the Weather (1981)
Time Bride (1981)
Going Under (1981)
Parables of Art (1981)
Fairy Tale (1981)
Amnesia (1981)
Down Among the Dead Men (1982)
Playing the Game (1982)
Slow Dancing With Jesus (1983)
Blind Shemmy (1983)
Reunion (1983)
A Cold Day in the Mesozoic (1983)
Afternoon at Schrafft`s (1984)
Golden Apples of the Sun (1984)
The Black Horn (1984)
The Gods of Mars (1985)
The Clowns (1985)
Between the Windows of the Sea (1985)
Tattoos (1986)
Visitors (1987)
The Apotheosis of Isaac Rosen (1987)
Sentry (1988)
Tea (1988)
Blues and the Abstract Truth (1988)
Kaddish (1989)
The Incompleat Ripper (1990)
Voices (1991)
Jumping the Road (1992)
Life in the Air (1992)
The Extra (1993)
The Glass Casket (1993)
Vapors (1993)
Art Appreciation (1993)
Afternoon Ghost (1994)
Counting Coup (1994)
Jubilee (1995)
Ships (1996)
Blind Eye (1996)
Niagara Falling (1997)
Marilyn (2000)
Ting-a-Ling (2001)
Cafe Culture (2007)
Kogumikud 7
Run for the Stars / Echoes of Thunder (1991)
Visitations (2003)
The Fiction Factory (2005)
Da Vinci Rising / The Diamond Pit (2010)
The Economy of Light / Jubilee (2011)
Antoloogiad 29
Future Power (1976)
Faster Than Light (1976)
Immortals: Short Novels of the Transhuman Future (1978)
Aliens! (1980)
Unicorns! (1982)
Magicats! (1984)
Bestiary! (1985)
Dogtales! (1988)
Dinosaurs! (1990)
Magicats II (1991)
Little People! (1991)
Unicorns II (1992)
Angels! (1995)
Dinosaurs II (1995)
Three in Time (1997)
Nebula Awards 32 (1998)
Dreaming Down-Under (1998)
Three in Space (1998)
Armageddons (1999)
Future War (1999)
Future Sports (2002)
Beyond Flesh (2002)
Nebula Awards Showcase 2005 (2005)
Robots (2005)
Beyond Singularity (2005)
Escape from Earth: New Adventures in Space (2006)
Futures Past (2006)
Wizards: Magical Tales from the Masters of Modern Fantasy (2007)
Legends of Australian Fantasy (2010)


If you are a serious drummer or collector this signature Outlaw Drums series is the drums for you. This series uses centuries-old wood that gives a blast of projection and clarity that is in direct relationship with the high resin content from the slow growth timber most of which was in the North American forests in the 1600s. Once this wood is gone it's gone.
Weathered Heart Pine Reborn Snare Drum features a soild wood shell made from reclaimed Heart Pine wood found in barns, homes, mills, or bridges built before 1900. This century-old wood has seen quite a bit of American history along its way, and has been left with a weathered texture on the exterior.
This vivid exterior siding captured on the side of the snare drum speaks for itself! 500 to 600 years of wind, snow, or rain can't destroy it. The beauty restored is ready for another lifetime...as a fine percussion instrument. It has its own unique sounds and characteristics. Because of the high resin content, heart pine drums are warm sounding with distinct resonance. The resin gives these drums a full body sound with lots of sensitivity. The ghost notes are very clear. This is a great all around snare for articulate drummers and power house drummers. Great for all genres of music.


The designs that started it all - our sports decor showcase all your favorite pastimes and are the perfect addition to kids' rooms, offices, sports bars, gyms, man caves, you name it.
All of our designs are hand bent and welded together to create each unique piece. They are handcrafted with flat bar steel which is powder coated for both indoor and outdoor use.


text:
Q: Set focus to 1st textbox in items control Let's say I have an items control that is bound to a list of items on the VM. Inside the datatemplate is a textbox. How would I set focus to the first textbox in either XAML or the VM?
Thanks in advance for any help!
<ItemsControl ItemsSource="{Binding UsageItems}" Grid.Row="1" Focusable="False">
<ItemsControl.ItemTemplate>
    <DataTemplate>
            <Grid Margin="0,0,0,3">
            <Grid.ColumnDefinitions>
                <ColumnDefinition Width="100"/>
                <ColumnDefinition Width="10"/>
                <ColumnDefinition Width="Auto"/>
                <ColumnDefinition Width="10"/>
                <ColumnDefinition Width="Auto"/>
                <ColumnDefinition Width="10"/>
                <ColumnDefinition Width="Auto"/>
            </Grid.ColumnDefinitions>

            <TextBlock Text="{Binding Month}" Style="{StaticResource Local_MonthLabel}" />
            <core:NumericTextBox Value="{Binding Actual, Mode=OneWay}" Style="{StaticResource Local_ActualUsageEntry}" Grid.Column="2"/>

            <core:ValidationControl Instance="{Binding Model}" Grid.Column="4" PropertyName="{Binding MonthNumber, StringFormat=AdjustedUsage{0}}">
                <core:NumericTextBox Value="{Binding Adjusted}"  DefaultValueIfNull="0" Style="{StaticResource Local_AdjustUsageEntry}" x:Name="AdjustmentEntry" inventoryLocationSetup:InitialFocusBehavior.Focus="True" />
            </core:ValidationControl>

            <telerik:RadComboBox ItemsSource="{Binding Converter={StaticResource Converter_EnumToEnumMemberViewModel}, Mode=OneTime, Source={x:Type Enums:UsageAdjustmentTypes}}" SelectedValue="{Binding Code, Mode=TwoWay}" Grid.Column="6" Style="{StaticResource Local_CodeSelector}"/>

        </Grid>
    </DataTemplate>
</ItemsControl.ItemTemplate>

A: I use an attached behaviour:
public static class InitialFocusBehavior
{
    public static bool GetFocus(DependencyObject element)
    {
        return (bool)element.GetValue(FocusProperty);
    }

    public static void SetFocus(DependencyObject element, bool value)
    {
        element.SetValue(FocusProperty, value);
    }

    public static readonly DependencyProperty FocusProperty =
        DependencyProperty.RegisterAttached(
        "Focus",
        typeof(bool),
        typeof(InitialFocusBehavior),
        new UIPropertyMetadata(false, OnElementFocused));

    static void OnElementFocused(
        DependencyObject depObj, DependencyPropertyChangedEventArgs e)
    {
        FrameworkElement element = depObj as FrameworkElement;
        if (element == null)
            return;
        element.Focus();
    }
}

Then in the XAML bind it to True for the element you want focused:
<TextBox Width="200" Height="20" local:InitialFocusBehavior.Focus="True" />

=== UPDATE ===
Sorry, the code above just shows how to use a behaviour to give focus to a control on the page, if you want to do it to an element in the first item in an ItemControl then you'll have to instead apply the behavior to the ItemsControl itself and then in your update handler find the child by doing something like this instead:
static void OnElementFocused(DependencyObject depObj, DependencyPropertyChangedEventArgs e)
{
    ItemsControl itemsControl = depObj as ItemsControl;
    if (itemsControl == null)
        return;
    itemsControl.Loaded += (object sender, RoutedEventArgs args) =>
    {
        // get the content presented for the first listbox element
        var contentPresenter = (ContentPresenter)itemsControl.ItemContainerGenerator.ContainerFromIndex(0);

        // get the textbox and give it focus
        var textbox = contentPresenter.ContentTemplate.FindName("myTextBox", contentPresenter) as TextBox;
        textbox.Focus();
    };
}

You'll notice that I'm setting the focus inside the OnLoaded handler because I'm assuming that the items won't have been attached yet when the control is first created.
Also you've probably already figured it out by "local" is just the namespace that the InitialFocusBehavior class is defined in, you'll need to add something like this at the top of the xaml:
xmlns:local="clr-namespace:YourProjectNamespace"


Using advanced brain imaging, researchers have matched certain behavioral symptoms of schizophrenia to features of the brain's anatomy. The findings, at Washington University School of Medicine in St. Louis, could be a step toward improving diagnosis and treatment of schizophrenia.
"By looking at the brain's anatomy, we've shown there are distinct subgroups of patients with a schizophrenia diagnosis that correlates with symptoms," said senior investigator C. Robert Cloninger, MD, PhD, the Wallace Renard Professor of Psychiatry and a professor of genetics. "This gives us a new way of thinking about the disease. We know that not all patients with schizophrenia have the same issues, and this helps us understand why."
When the researchers looked at abnormalities across the corpus callosum, they found that certain characteristics revealed in the brain scans matched specific symptoms of schizophrenia. For example, patients with specific features in one part of the corpus callosum typically displayed bizarre and disorganized behavior. In other patients, irregularities in a different part of that structure were associated with disorganized thinking and speech and symptoms such as a lack of emotion. Other brain abnormalities in the corpus callosum were associated with delusions or hallucinations.
In 2014, the same team of researchers reported evidence suggesting that schizophrenia is not a single disease but a group of eight genetically distinct disorders, each with its own set of symptoms. In that study, Cloninger and Igor Zwir, PhD, an instructor in psychiatry at Washington University and an associate professor in the Department of Computer Science and Artificial Intelligence at the University of Granada, Spain, found that distinct sets of genes were strongly associated with particular clinical symptoms.
The current study provides further evidence that schizophrenia is a heterogeneous group of disorders rather than a single disorder. The researchers believe it will be important for future studies to focus on how precise gene networks are linked to specific brain features and individual symptoms so that treatments can be tailored to patients. Currently, therapies for schizophrenia tend to be more all-encompassing, regardless of an individual patient's symptoms.
In analyzing the clusters of genes and the brain scans, the researchers developed a complex method of analysis, similar to what companies such as Netflix use to predict movies that viewers might want to stream.
"We didn't start with people who had certain symptoms and then look to see whether they had corresponding abnormalities in the brain," Zwir said. "We just looked at the data, and these patterns began to emerge. This kind of granular information, combined with data about the genetics of schizophrenia, one day will help physicians treat the disorder in a more precise way."
NIH/National Institute of Mental Health, Spanish Ministry of Science and Technology, R.L. Kirchstein National Research Award, Stephen and Constance Lieber, Sidney R. Baier Jr.


在尊嚴和權利上一律平等。 and equal in dignity and rights.
並應以兄弟關係的精神相對待。 and should act towards one another in a spirit of brotherhood.
^ Only p m d n g c a e ê ü (from p m d n k j ä è dropped-e ü) approximate the French norm. Other letters have been reassigned so that the sets of letters in groups such as d t n l and g k h are similar in shape.
^ 國語點字自學手冊, National Taiwan Library, retrieved on April 18, 2016.
^ [sic] One might expect ㄐ j (/tɕ/) to pair with ㄗ z (/ts/), by analogy with the others. Compare here, where the character 學 xué is rendered ⠑⠦⠂ "süé". Historically it could have been either. The principal behind the assignments seems to be that, of the historically appropriate pairs of letters g~z, k~c, and h~s, the letter with the fewer dots is used for j, q, x.