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[Current Drama 2019] Aide/Chief of Staff, 보좌관 - Mon & Tue @ 21:30 KST - Season 2 premieres in November
By larus, March 19 in k-dramas & movies
lee jung jae
shin min ah
larus 58,626
LocationRomania
JTBC DRAMA 2019
Aide/ Chief of Staff
Genre: Drama, Political
Network: JTBC
Episodes: 10 (season 1) + 10 (season 2)
Director: Kwak Jung Hwan (Miss Hammurabi, The K2, The Slave Hunters, Conspiracy in the Court)
Writer: Lee Dae Il (Life on Mars, Bring it on, Ghost)
Release Date: June 14th - July 13th, 2019 (season 1)/ November 2019 (season2)
Runtime: Fridays & Saturdays 23:00 (following drama Beautiful World- season 1)
Monday &Tuesday (following drama - season 2
Production Company: NEW
OST:
Official site: HERE
"Advisor" tells the story of politicians who control the world while standing behind the spotlight and engage in the dangerous gambling of politics. It is also a survival story of the "super" advisor Jang Tae Joon (Lee Jung Jae) who is on his way to having the most power in the nation.
Lee Jung Jae as Jang Tae Joon
Shin Min Ah as Kang Sun Young
Lee Elijah as Yoon Hye Won
Kim Dong-Joon as Han Do-Kyung
Jung Jin Young as Lee Sung-Min (season 1)
Kim Kap Soo as Song Hee-Seob
Jung Woong In as Oh Won-Sik
Lim Won hee as Ko Seok-Man
Kim Hong-Fa as Jo Gap-Young
Kim Eung-Soo as Jang Choon-Bae
Lee Cheol-Min as Kim Hyung-Do
Jeon Jin-Ki as Lee Gwi-Dong
Jeon Seung-Bin as Kim Jong-Wook
Character descriptions:
Jang Tae-Joon ( Lee Jung Jae) graduated from the Korean National Police University and worked as a detective. He wanted to gain more power and decided to work in the National Assembly. Now, he is the chief aide to a 4-time lawmaker. He has excellent intuition, a cold-blooded decisiveness and a strong desire to win. He was able to place his lawmaker in the position of the party representative, but Jang Tae-Joon has higher ambitions.
Kang Sun-Young( Shin Min-ah) is a first year lawmaker who got elected through proportional representation and is a spokesperson for her party. She worked as a lawyer and hosted a current affairs TV program prior to becoming a lawmaker. She is ambitious and does her job well. Kang Sun-Young has an awkward relationship with Jang Tae-Joon, whose boss is a rival of the senior lawmaker who got her to become proportional representation lawmaker.
Character Chart:
Character posters:
Teasers/Trailers
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PLEASE GIVE CREDIT TO WHERE CREDIT IS DUE
Lee Jung Jae In Talks To Make First Drama Comeback In 10 Years
by D. S.kim
Lee Jung Jae might be making his long-awaited drama comeback!
On January 23, TV Daily reported that Lee Jung Jae will be starring in upcoming drama "Advisor" (literal title).
The drama is written by Lee Dae Il, the writer behind OCN's remake of "Life On Mars." It will also be helmed by director Kwak Jung Hwan of "Miss Hammurabi" and "Slave Hunters."
In response, a source from Lee Jung Jae's agency Artist Company stated, "While it is true that [Lee Jung Jae] received an offer, nothing has been confirmed. He is still reviewing the offer."
If the actor accepts the offer, he will be making his return to the small screen for the first time in 10 years. The last drama he appeared was the 2009 MBC drama "Triple."
https://www.soompi.com/article/1297067wpp/lee-jung-jae-talks-make-first-drama-comeback-10-years
Lee Jung-jae considers dramaland comeback with Life on Mars writer
by tipsymocha
What is in the water in Chungmuro these days? I feel like we're getting quite a few movie stars back into dramaland as of late, and I'm over the moon about it. The latest Chungmuro regular considering a return to the small screen is the OG oppa extraordinaire Lee Jung-jae (Along With the Gods: The Last 49 Days) in a drama titled Aide (as in political assistant).
It sounds like the drama itself is in its early days yet, but news outlets are understandably excited to announce that Lee Jung-jae is even considering a drama role, which would be his first since 2009's Triple (holy cow, was that already 10 years ago?!). The synopsis for the planned drama hasn't been released, nor has it found a broadcaster to call home, but there are some creative powerhouses behind the scenes: Writer Lee Dae-il, who penned the lauded Life on Mars adaptation over on OCN, will be in charge of the script, while production company NEW, which has Descended From the Sun and Beauty Inside in its drama lineup and an even more impressive film roster to boast of, will be producing Aide.
In the director's seat is PD Kwak Jung-hwan, who is known for slick action dramas Chuno and The K2, as well as the more recent Ms. Hammurabi. I'm not entirely sure what to expect of Aide based on this writer-director duo alone, but I really do hope that it's something good enough to lure Lee Jung-jae back onto television. And would it be too greedy to ask that his role incorporate some comedy? Because the man can do comedy like nobody's business.
http://www.dramabeans.com/2019/01/lee-jung-jae-considers-dramaland-comeback-with-life-on-mars-writer/
Lee Jung Jae and Elliya Lee in Talks for Political Drama Aide
http://koalasplayground.com/2019/03/05/lee-jung-jae-and-elliya-lee-in-talks-for-political-drama-aide/
Lee Jung Jae And Shin Min Ah Confirmed For New JTBC Drama
Lee Jung Jae and Shin Min Ah will be uniting for a drama!
On March 18, the production team of JTBC's upcoming Friday-Saturday drama "Advisor" (tentative title) revealed that Shin Min Ah is confirmed for the female lead role. It was previously announced that Lee Jung Jae was in talks for the male lead role, and the actor has since confirmed.
Shin Min Ah will be taking on the role of Kang Sun Young, a female politician who attempts to break the glass ceiling. She used to be a talented lawyer with experience of hosting a TV program that addresses current events, and she is now a newly-selected committee member of her political party.
https://www.soompi.com/article/1311261wpp/lee-jung-jae-and-shin-min-ah-confirmed-for-new-jtbc-drama
Lee Jung-Jae & Shin Min-A cast in JTBC drama series "Aide"
Lee Jung-Jae and Shin Min-A are cast for lead roles in JTBC drama series "Aide" (literal title). The drama series is set within the backdrop of the national assembly. Lee Jung-Jae will play Jang Tae-Joon. He is an ambitious aide to a 4 time elected lawmaker. Shin Min-A plays Kang Sun-Young. She is a newly elected lawmaker and also ambitious.
"Aide" will first air towards the end of May, 2019 in South Korea (takes over JTBC's Friday & Saturday 11 PM time slot after "Beautiful World").
http://blog.asianwiki.com/korean-dramas/lee-jung-jae-shin-min-a-cast-in-jtbc-drama-series-aide
Lee Elijah was offered a role in this drama but I don`t know if it was Shin Min Ah`s role or something else. We`ll see.
I am excited to see Lee Jung Jae back on the small screen. I was wondering when Shin Min Ah will return on the small screen as well. I like the genre and the cast is good. I will wait for this drama.
jongski 37,326
Fan Level: Hardcore
Oh wow for real? He''s going to make drama comeback? Triple was like a decade ago! It's polital genre I lik andit's on JTBC so I'll be waiting.
34 minutes ago, jongski said:
Yes, it is true. I can`t wait to know more about the drama. The last political drama I watched was Assembly with Jung Jae-Young and Song Yoona.
From the synospis it looks like an interesting drama.
JTBC's upcoming drama Aide will be made into 2 seasons (with total 20 episodes). The first season will premiere in May while the second one will follow after Melo Suits Me and My Country in November.
I don`t know what is the reason for that. Maybe they want to film the drama without pressure of time. I don`t like the season concept but it is good that we`ll have the drama in the same year.
5 hours ago, larus said:
I don`t know what is the reason for that. Maybe they want to film the drama without pressure of time. I don`t like the season concept but it is good that we`ll have the drama in the same year.
@larus So it's a new concept? So 10 episodes season 1? and then we'll have the next 10 in season 2?
By the way any news of other cast as well. I wonder who will play the law makers. I mean the President character. And who could be the seond lead. Guess I'm excited.
1 hour ago, jongski said:
So it's a new concept? So 10 episodes season 1? and then we'll have the next 10 in season 2?
Yes, but I don`t know if it is a new format or just an exception for a justified reason.
By the way any news of other cast as well. I wonder who will play the law makers. I mean the President character. And who could be the seond lead. Guess I'm excited.
So far, Lee Elijah was mentioned to have an offer for a role but I don`t know if it was the role of Shin Min ah`s character or another one. I am sure the cast will be very good. I don`t worry at all but, of course, I am curious just like you.
Friendly kitty 826
LocationUkraine
JTBC has been filming great dramas lately. Therefore, I look forward to this drama. Especially because we are waiting for the return of such cool actors ...
And yes, it is very interesting, why the drama was divided into 2 seasons? Maybe the channel now wants to show dramas in this way? Do they experiment with the viewer?
Curious!
Shin Mina Makes TV Comeback as Lee Jung Jae`s Leading Lady in Political Drama aide
http://koalasplayground.com/2019/03/20/shin-mina-makes-tv-comeback-as-lee-jung-jaes-leading-lady-in-political-k-drama-aide/
ilmare 4,290
SunTaek
am excited for tis drama. Lee Jung Jae is my #1 fave actor. watched almost all his works, which i can get hold of.
JTBC 'assistant' confirmed Elija's appearance, Kim Dong-joon positively under review (official position)
Kim Dong-joon was also nominated for the role of 'assistant'. An official of the agency's major 9 said that he was "positively under review" with Kim Dong-joon's "assistant appearance" on the news the same day.
On the other hand, 'Aide' is a drawing of dangerous gambling of real political players who move the world behind the spotlight, and a fierce survival period of super advisor Chang Tae-joon who is pointing to the peak of power.
It will be broadcasted at the end of May.
http://www.newsen.com/news_view.php?uid=201903221620540310
The actress Lee Elijah has confirmed to appear in the JTBC new drama Aide.
Her agency, King Kong, said on the 22nd, "Lee Elijah appears on in the drama as an 'assistant'." The actress has been recognized for her recent role Min Yura in SBS 'Empress of Dignity'.
http://www.hankookilbo.com/News/Read/201903221660740578
The number of assistants & their grade level is making me dizzy
Lee Elijah Joins Shin Min Ah And Lee Jung Jae In New Political Drama
by C. Hong
Lee Elijah has confirmed her casting in a new drama!
On March 28, her agency, King Kong by Starship, stated, "Lee Elijah has joined JTBC's new Friday-Saturday drama in the role of political aide Yoon Hye Won."
Shin Min Ah and Lee Jung Jae have already confirmed that they will be appearing as the leads in this new drama, which is tentatively titled "Advisor." "Advisor" tells the story of the political aides and advisors who are the real power behind the spotlight.
Shin Min Ah plays Kang Sun Young, a female politician who attempts to break the glass ceiling in politics, and Lee Jung Jae plays Jang Tae Joon, a "super-advisor" who is aiming for the height of power.
Lee Elijah's character, Yoon Hye Won, is a Level 6 secretary who has risen to this high position despite her young age. She is more passionate and hardworking than anyone around her, but also has a strong sense of wrong and right and refuses to take the path of temptation. She works in the National Assembly alongside Jang Tae Joon, who is a Level 4 aide.
Members of the National Assembly typically have 9 aides: two Level 4 advisors, two Level 5 secretaries, one secretary each in Levels 6, 7, 8, and 9, and one intern
https://www.soompi.com/article/1313400wpp/lee-elijah-joins-shin-min-ah-and-lee-jung-jae-in-new-political-drama
Lee Elijah, Kim Dong-joon join Lee Jung-jae, Shin Mina in JTBC's Aide
Lee Jung-jae, Shin Mina, Lee Elijah, Kim Dong-joon
When done well, political machinations can be even more thrilling than blockbuster action scenes. And somehow JTBC has managed to lure Chungmuro regular Lee Jung-jae (Sabaha) back to dramaland with their upcoming drama Aide, ending a decade-long absence. So, I'm hoping that his return is a sign that we have some delightfully crafty and intelligent political maneuvering to look forward to in the show.
News of Lee Jung-jae and Shin Mina's (Tomorrow With You) casting was announced a little over a week ago, and now we have reports confirming that Lee Elijah (An Empress's Dignity) and Kim Dong-joon (About Time) will be joining the supporting cast. Aide will put a spotlight on Korea's political landscape, and more specifically, on the shadowy power behind the throne, wielded by those who "support" politicians. The show's description calls them players engaged in a dangerous gamble, and among them is one aide in particular who has his heart set on reaching the pinnacle of power. Three guesses as to who that aide is.
more http://www.dramabeans.com/2019/03/lee-elijah-kim-dong-joon-join-lee-jung-jae-shin-mina-in-jtbcs-aide/
irilight 62,743
@larus, thank you for starting the thread.
I too am excited to have Lee Jung Jae back in a drama.
Waving hi to everyone here. Both familiar and new faces
Shin Min Ah, Lee Jung Jae, And More Gather For 1st Script Reading Of New Political Drama
The upcoming JTBC Friday-Saturday drama "Advisor" (tentative title) is raising anticipation with stills from the drama's first script reading!
The reading was held on March 26 and was attended by director Kwak Jung Hwan, screenwriter Lee Dae Il, and cast members including Lee Jung Jae, Shin Min Ah, Lee Elijah, Kim Dong Jun, Jung Jin Young, Kim Kap Soo, Jung Woong In, Im Won Hee, Kim Hong Fa, Kim Eung Soo, Lee Chul Min, Jeon Jin Ki, and Do Eun Bi.
After everyone exchanged greetings and settled down, director Kwak Jung Hwan stated, "I don't believe it only takes a director and screenwriter to complete a drama. I hope that we can all share many ideas that we can incorporate into the drama to create an even better production for the viewers."
Lee Jung Jae will be taking on the role of Jang Tae Joon, the chief aide of four-time congressman Song Hee Seob (Kim Kap Soo), who graduated at the top of his class in the police academy but turned to politicians as he sought more power. He will be at the center of the drama that unfolds, and his character will teeter along the edge of right and wrong, finding his balance through intuition and cold judgment. This is set to be Lee Jung Jae's first drama in approximately ten years, so anticipation is high for the actor.
Alongside him is Shin Min Ah playing Kang Sun Young, a first-time congresswoman and speaker of her political party. She is proud of her competency and competitiveness, and she hopes to break the glass ceiling. There will be tension between her and Lee Jung Jae as he is the chief aide to the rival of the senior lawmaker who nominated her for her candidacy.
They will be joined by Lee Elijah taking on the role of Yoon Hye Won, the chic secretary to Song Hee Seob, and Kim Dong Jun playing the enthusiastic intern Han Do Kyung. Others in the cast including Jung Jin Young playing first-time congressman Lee Sung Min, Kim Kap Soo playing four-time congressman Hong Hee Seob, Jung Woong In playing Hong Hee Seob's aide and head of the district office Oh Won Sik, and Im Won Hee taking on the role of Kang Sun Young's aide Go Seok Man.
The production staff stated, "Screenwriter Lee Dae Il's tight script and director Kwak Jung Hwan's excellent directing combined with the actors's talents at bringing their characters to life to create an amazing script reading," and "We're off to a strong start. We will bring to life the story of people who are the real players in politics. We hope everyone will anticipate it."
The drama is slated to begin airing in late May.
JTBC updates
[HanCinema's News] Jung Jin-young cast for "The President's Aide"
By William Schwartz on 2019/03/28 at 21:46 PST
On March 28th, the production company behind "The President's Aide" confirmed that Jung Jin-young would be joining the drama. The drama is a behind the spotlight look at political power struggles that centers around the titular aide, played by Lee Jung-jae.
Jung Jin-young, a longtime veteran of dramas and films, will ironically enough play a newbie legislator. Lee Jung-jae's character separates from Jung Jin-young because the lead character has ambition, while the junior one is motivated by a guileless sense of justice.
The casting is somewhat ironic, given that Jung Jin-young has been cast as sneaky or otherwise non standard heroes in the past. The casting fits well with the drama's concept of aiming to show a different side of the political process. "The President's Aide" will begin airing sometime in May.
Written by William Schwartz
https://www.hancinema.net/hancinema-s-news-jung-jin-young-cast-for-the-president-s-aide-128091.html
First script reading for JTBC drama series "Aide"
Frst script reading for JTBC drama series "Aide" (literal title) took place March 26, 2019 at Studio & NEW in Nonhyeon-dong, Seoul, South Korea. Main cast members including Lee Jung-Jae, Shin Min-A, Kim Dong-Joon, Lee Elijah, Jung Jin-Young, Kim Kap-Soo, Jung Woong-In and Lim Won-Hee attended. The drama series is set in the political world and has Lee Jung-Jae playing a chief aide to a 4-time lawmaker. Shin Min-A will play first year lawmaker Kang Sun-Young.
"Aide" first airs May, 2019 in South Korea.
http://blog.asianwiki.com/korean-dramas/first-script-reading-for-jtbc-drama-series-aide


Continuing his tradition of interpreting the styles of great painters in glass, Peter Layton's new series, Georgia, pays homage to celebrated artist Georgia O'Keeffe. The flowing, inky blues and greens found in Peter's designs reflect the movement and mystery in O'Keefe's work. The series, made in collaboration with Tate Modern, coincided with the launch of their 2016 exhibition dedicated to the iconic painter, recognised as a pioneer of twentieth-century art.


In our mission to get more people back on their feet, we often meet and talk with people and organizations that offer value in some way to the amputee community. While we have a degree of confidence in these organizations, we share these links with you as a courtesy—not as an official endorsement—and count on you to determine their fit with your needs.
Let us know if you'd like your organization added to our Resources page. Contact us at info@WaterGait.com.
The SandPadTM is an all-terrain stabilizer providing a wider base of stability than a normal crutch, cane or walker "tips" to support a user's weight for easy mobility without sinking into sand, grass, gravel or snow. Engineered in rubber and available in both 6" and 8" diameters, you can confidently use your crutches, cane or walkers on multiple terrains with the support provided by The SandPadTM. Order yours at TheSandPad.com.
The Web's most popular swim shop! This is where we get many of the swim shoes that we provide with our WaterGaitTM WaterLegs.
provide adaptive sports programs, clinics and activities that appeal to those served by the orthotic and prosthetic community.
and coordinate in-kind support for future Paralympic games.
The JTTF is a nonprofit organization whose mission is to better the lives of children and adults with disabilities on the First Coast by providing financial assistance, adaptive equipment, and research funding.
The Amputee Coalition of America's mission is to reach out to and empower people affected by limb loss to achieve their full potential through education, support and advocacy, and to promote limb loss prevention.
Copyright © 2019 Replacement Arts, Inc - All Rights Reserved.


No matter what type of bedding or how good a manager you are, the area in the barn that causes the most headaches might be in the calving area. This area is usually a large, open space with crowd gate dividers for separating soon-to-be mothers where managers rely on a heavy pack of straw and other organic bedding materials to keep the area clean and cows comfortable – just like in the "olden" days.
Despite the numerous advancements in design and integration of technology in other parts of the barn (think cow brushes or micro-sprinkler cooling systems), the calving area has remained pretty much unchanged since your grandfather's days. And we still deal with the same issues as your grandfather – cleanliness, comfort, removal and replacement of bedding. At one of the most crucial and vulnerable stages in a cow's, and especially a calf's, life we rely on old technology.
We at North Brook have been working on ways to improve this aspect of barn and cow management for quite some time. We think we have cracked the code to create a softer, cleaner environment for the future of your farm – your calves – to enter the world.
Introducing the North Brook Farms Calving Pen Mattress System. North Brook integrates 21st century memory foam technology and advances in waterproof surfaces to reimagine how we manage fresh and calving cows. Instead of relying on a deep bedding pack, we replace bedding with a memory foam mattress system that supports laboring moms and creates a softer, more stable, comfortable surface for new calves to find their legs. The foam mattress is covered wall to wall with a single piece, waterproof topcover that can be customized to your space. We use our highly successful Alloy Top Cover in a single, factory seamed, wall-to-wall piece to meet your specific stall dimensions.
This system also substantially lowers calf pen management costs by decreasing, and possibly eliminating, bedding costs as well as cuts back on the labor hours needed to clean the area between calving events. Instead of firing up the skid-steer and mechanically removing the bedding, the mattress system can be sprayed down with a pressure washer and even sanitized with a mild bleach solution to improve hygienic conditions and reduce infection rates. The Calving Pen Mattress System results in greater efficiencies in the calving pen, cleaner conditions for mothers and calves, and less labor for your hired hands.
No matter what you have in your stalls, every dairy has a different and unique set of challenges when it comes to freshening your cows. North Brook has introduced new technologies to solve the very old frustration of deep bedded packs in calving areas. The Calving Pen System is meant to be a helpful tool to dairymen and make their operations more robust and sustainable for future generations of both family and cows. The calving pens are where it all begins, let's get these calves off on the right hoof.
We're always looking for feedback on new products, so send me questions and comments and check out our website for more information.
Newly installed calving pen at a local dairy in Central New York. June 2014.


Choosing a Mortgage Broker in Delray Beach, FL | Ace Mortgage Loan Corp.
Purchasing a home is a special moment for people of all walks of life. It signals that you have established a presence in a place and are looking for a long term living solution. In a volatile housing market, the fine print of your mortgage can make or break your home purchasing experience as well as your financial situation in the future. Employing the services of a capable and qualified mortgage broker can be helpful as you embark on this new journey by stepping with the right foot forward. One of the most common misunderstandings for first time homebuyers is the propensity to go to their bank for sound mortgage advice. The bank is usually biased and will give you guidance based on their priorities, particularly if it is a national bank chain. Seeking help from a mortgage loan company like Ace Mortgage Loan Corporation in Delray Beach, FL is the right choice for those looking to become a homeowner in Broward or Palm Beach Counties.
A private banker is no comparison to a licensed mortgage broker. A broker can offer relevant insights into what to expect in the housing market and is trained and qualified to give financial advice when it pertains to a mortgage. Looking for a broker should be done with intense research as their normally are many to choose from no matter where you are.
A broker's knowledge will prove to be very useful and finding one with a good track record will help ensure the likeliness that they have dealt with an experienced a situation like the one you may be in. Along with their experience goes their business model. If your broker is getting their money from a lender then they may not be as neutral as you need. Paying broker fees will help you avoid this conundrum. Ask your local mortgage loan corporations to get a handle on what sort of rates you can expect.
If you choose to pay fees asked by a broker then shopping around for one with affordable rates will help you save money and improve your mortgage broker experience as a whole. Feel free to ask about their past clients and find out for yourself if the broker you're on the verge of choosing is decent and responsible.
If you want to make sure your home buying experience goes a smoothly as possible, go to a company like Ace Mortgage Loan Corp., which specializes in home loans in Delray Beach, FL.
This entry was posted in Boca Raton, broward county mortgage, Coconut Creek, Davie, Delray Beach, fha, home loan, Margate, mortgage, mortgage broker, mortgage loan, Mortgages, Palm beach county, palm beach county mortgage, Plantation, Pompano Beach, refinance. Bookmark the permalink.


What Are Platelet Function Disorders?
Platelet function disorders are a group of bleeding disorders where the platelets do not function appropriately, leading to bleeding. These disorders can be inherited (passed down in families) or acquired (developed at later time).
What Are the Symptoms of a Platelet Function Disorder?
What Causes Platelet Function Disorders?
Wiskott-Aldrich syndrome: This is a syndrome of immunodeficiency and dysfunctional platelets. It is characterized by very small platelets (most platelet function disorders have normal to large platelets).
Medications: Medications like aspirin, dipyridamole (Persantine), and clopidgrel (Plavix) are designed to reduce the function of platelets. Ibuprofen also decreases the effectiveness of platelets but less than aspirin.
How Are Platelet Function Disorders Diagnosed?
Opposed to other platelet disorders, which are often issues with the platelet number (elevated or decreased), platelet function disorders may have normal platelet counts.
Other types of platelet function disorders can have thrombocytopenia, or low platelet count. The platelets should be reviewed under the microscope on a peripheral blood smear. Several of the congenital platelet function disorders result in platelets that are larger than normal. Others are missing key components of the platelets, called granules, which can be seen. Sometimes the platelets are normal in appearance and size.
The remaining work-up begins similarly to other bleeding disorders. Opposed to hemophilia (a disorder of coagulation factors), screening tests like prothrombin time (PT) and partial thromboplastin time (PTT) are normal. Diagnosing platelet function disorders require specialty testing. Below is a short list of commonly used tests.
Bleeding time: This test is not considered specific to platelet function disorders and because of test limitations is not considered an accurate test of the clotting system.
Platelet function assay: This is considered by many to be a good screening test for platelet disorders. This test is affected by the platelet count and may not be accurate if you have low platelet counts.
Platelet aggregation testing: This test looks at how well the platelets stick to one another (aggregation) in response to different stimuli. This test can also be used to measure the effectiveness of aspirin or clopidogrel (Plavix) therapy.
Platelet electron microscopy: This is a special way to look at platelets with a special microscope that can see the individual parts of the platelet.
Treatment is based on the individual platelet function disorder you have. Some platelet function disorders rarely need treatment unless you are injured or require surgery.
Aspirin and NSAIDs: Avoid aspirin or non-steroidal anti-inflammatory (NSAIDs) like ibuprofen. These medications reduce the function of platelets which may worsen the bleeding risk.
Hormonal contraceptives: Similar to other causes of severe menstrual bleeding, hormonal contraceptives can be used to keep menstrual bleeding to a minimum.
Anti-fibrinolytic medications: Because it can be difficult for the body to make stable clots, particularly on the moist surfaces of the mucosa (mouth, nose, etc.), antifibrinolytic medications like Amicar or Lysteda may be used to stop bleeding. These medications are commonly used in these conditions for nosebleeds, gum bleeding, and menorrhagia. They can also be used after surgical procedures (particularly, mouth, nose, and throat) to prevent bleeding.
Platelet transfusions: Even in platelet function disorders with normal platelet counts, platelet transfusions may be used for severe bleeding or if you need to go to surgery.
Factor VIIa (NovoSevenRT) infusion: This factor replacement product can be used in some patients with platelet function disorders. This is used mostly in patients that are unable to receive platelet transfusions as a treatment option.
What Causes Your Platelet Count to Be Low?
What Do Your Blood Platelets Do?


The Nusantara Statement calls upon faith leaders worldwide to work together for peace, equality and the protection of human dignity.
Among the Christians signing the declaration were Johnnie Moore, founder of the Kairos Company, and Archbishop Joseph D'Souza, president of the All India Christian Council.
The statement was issued at the Second Global Unity Forum in Yogyakarta, Indonesia this week, hosted by moderate Islamic organisation Nahdlatul Ulama and attended by faith leaders from over 20 countries.
Archbishop D'Souza welcomed the statement, saying that the weaponization of Islam as well as Hinduism and Christianity 'has led to hate, violence and division'.
'And as it usually happens, the ones who suffer the most are the poor, marginalized and the outcastes. This must end,' he said.
He continued: 'Every major world religion can agree on these two things: every human life is equal and has inherent dignity, and all violence is evil and not from God.
While Islam's birthplace is in the Middle East, Archbishop D'Souza said it was 'logical' that the statement emerged from Indonesia, the world's most populous country, which he said 'has historically represented the best of Islam'.
Nahdlatul Ulama was founded by late Indonesian President Abdurrahman Wahid and aims, among other things, to promote a tolerant and inclusive Islam.
During his lifetime, President Wahid received the Magsaysay Award and the Top Honor Prize by the World Peace Prize Awarding Council for his work in building democracy in Indonesia and promoting peace and inter-religious cooperation.
He also received the Simon Wiesenthal Center's prestigious 'medal of valor' for his work promoting peaceful coexistence between religious communities.
Rev Moore, a fellow Wiesenthal Center honoree, said he was 'honored' to sign his name on the statement.
He added: 'There is a new spirit of friendship and cooperation emerging among the most influential leaders of the world's largest religious communities in the active promotion of peaceful coexistence, in unrelenting opposition to extremism and with a determination to make the world a better place for our children.


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text:
OCTOBER 2018 - ADDITIONS TO THE LIBRARY - 6 OF THE BEST!
Accumulations last month included these six little beauties.....
A couple of purchases, one on spec., one after reading the first in a two book series, an Amazon freebie from an author I've been tempted by but never committed to before, my monthly Patreon reward book from Fahrenheit Press and two down to a bit of author generosity - hats off to Dave Putnam and Tom Pitts.....
Tony Spinosa - The Fourth Victim (2008) - purchased
Tony Spinosa aka Reed Farrel Coleman penned a couple of books with Joe Serpe and Bob Healy. I loved the first after waiting over ten years to read it - Hose Monkey
Several home heating oil delivery drivers have been robbed and murdered. Joe Serpe and Bob Healy, now partners in an oil company of their own, make sure their drivers are safe. But when Rusty Monaco, another ex-NYPD detective, becomes the killer's fourth victim, Serpe and Healy take matters into their own hands. In the course of their unofficial investigation they stumble upon a completely different set of crimes that lead both Serpe and Healy back onto the streets they protected as cops.
Ben Lieberman - Odd Jobs (2010) - purchased
Not an author I had previously heard of nor a book either. I think one of my Goodreads friends added it and I was intrigued.
Hauling cow carcasses through a freezing warehouse isn't Kevin Davenport's idea of summer fun. But it's not his first crappy job. And with tuition due and his widowed mom strapped for cash, he's in no position to turn down good pay. But there's more than meatpacking happening at Kosher World Meat Factory. And the truth isn't quite so - well - kosher. Turns out the business is a front for a criminal syndicate. While working at the corrupt meat factory, Kevin discovers who killed his father, and now all bets are off. Kevin finally has the chance to settle the score, and he'll tackle any job - club fighting, bookmaking, even drug dealing - to earn his revenge. But can he do it without becoming the very thing he's trying to destroy? Or, God forbid, flunking out of school? The Sopranos meets Animal House in this darkly comic coming-of-age novel about the price of vengeance - and the burden of truth.
Pete Brassett - Terminus (2017) - Amazon FREEBIE
A seven book long Scottish detective series that I've had an eye on, but never took the plunge. I'm usually a bit OCD with series books, preferring to go from first to wherever but I don't think I've time to read all seven.
Detective Munro is on the back foot when a dangerous killer always seems to be one step ahead.
Having been the victim of a hit and run accident, and despite being black and blue, DI Munro wastes no time in trying to find out the identity of the perpetrator.
In the meantime, a junior detective receives a call from a concerned member of the public, worried that a recently deceased friend's will had been unlawfully changed.
What connects these two events will be crucial to the detective's investigation. But when prime witnesses turn up dead, they'll discover they have a more serious case on their hands. With attempted murder upgraded to a full-scale murder investigation, can the police close in on a mysterious killer or will Munro be finally outwitted?
TERMINUS is the fifth book by Pete Brassett to feature detectives James Munro and Charlotte West.
Ian Patrick - Stoned Love (2018) - Fahrenheit Press monthly book
I have a copy of Ian Patrick's debut Rubicon on the device for a read sometime.
Detective Sergeant Sam Batford has been lying low at a remote safe house in the highlands of Scotland. He's doing his best not to attract the attention of the enemies he made, on both sides of the law, during his last under-cover operation but Batford knows he's just killing time until he's called to account.
Inevitably the sharks begin to circle and as Batford is called back to front-line action in London he's thrown into a deadly game of cat and mouse where it seems everyone is out to get him.
After having to endure a frustrating resolution to their previous undercover operation together DCI Klara Winter from the National Crime Agency is determined to prove that Batford has crossed the line into criminality and finally bring him to face justice.
All Sam Batford wants is to outwit his enemies long enough to stay alive and come out ahead of the game.
Ian Patrick's previous Sam Batford novel, RUBICON has been optioned by the BBC.
Praise from other authors.
'A taut, exciting and utterly authentic thriller with a compelling narrator' - Louise Voss
'A sharp, slick, gripping and compelling novel' - Jane Isaac
Tom Pitts - 101 (2018) - review copy from author
Tom Pitts has been enjoyed before with American Static read last year. A few more from him sit on the pile. This drops in November I believe.
On the cusp of pot legalization in California, Jerry runs afoul of some San Francisco bikers in the marijuana game. He flees straight up Highway 101 to Humboldt County to hide out deep in the hills at Vic's, a reclusive pot farmer and old pal of his tough-as-nails mother. But trouble finds Jerry no matter where he goes and soon the bikers, a pair of stone killers, and a Russian weed tycoon named Vlad the Inhaler are all hot on Jerry's trail.
Fallout from the unfolding chaos piques the interest of SFPD detective, Roland Mackie, when he learns Jerry's host, Vic, is somehow involved. It opens a twenty-year-old wound, an unsolved case called the Fulton Street Massacre, and Mackie is willing to do whatever it takes to get a pair of cuffs on the elusive Vic.
When Jerry and his protectors are chased off the mountain and back down the 101 to an inevitable showdown back in the Bay, he learns Vic is much more than his host, he's a mentor, his mother's hero, and the toughest man he's ever met.
With an unforgettable cast of characters and an action-packed plot, 101 is a wild ride through Northern California's "emerald triangle."
Lou Berney - November Road (2018) - thanks to the kindness of Dave Putnam
I've read Lou Berney before and his latest one is causing a stir over in the US at the minute. Author Dave Putnam (Bruno Johnson series) recommended this to me and kindly sent me his copy when I told him it drops in the UK in 2019. What a very nice man!
Lou Berney's earlier books on the blog - Gutshot Straight and Whiplash River
Set against the assassination of JFK, a poignant and evocative crime novel that centers on a desperate cat-and-mouse chase across 1960s America - a story of unexpected connections, daring possibilities, and the hope of second chances from the Edgar Award-winning author of The Long and Faraway Gone.
Frank Guidry's luck has finally run out.
A loyal street lieutenant to New Orleans' mob boss Carlos Marcello, Guidry has learned that everybody is expendable. But now it's his turn - he knows too much about the crime of the century: the assassination of President John F. Kennedy.
Within hours of JFK's murder, everyone with ties to Marcello is turning up dead, and Guidry suspects he's next: he was in Dallas on an errand for the boss less than two weeks before the president was shot. With few good options, Guidry hits the road to Las Vegas, to see an old associate - a dangerous man who hates Marcello enough to help Guidry vanish.
Guidry knows that the first rule of running is "don't stop," but when he sees a beautiful housewife on the side of the road with a broken-down car, two little daughters and a dog in the back seat, he sees the perfect disguise to cover his tracks from the hit men on his tail. Posing as an insurance man, Guidry offers to help Charlotte reach her destination, California. If she accompanies him to Vegas, he can help her get a new car.
For her, it's more than a car - it's an escape. She's on the run too, from a stifling existence in small-town Oklahoma and a kindly husband who's a hopeless drunk.
It's an American story: two strangers meet to share the open road west, a dream, a hope - and find each other on the way.
Charlotte sees that he's strong and kind; Guidry discovers that she's smart and funny. He learns that's she determined to give herself and her kids a new life; she can't know that he's desperate to leave his old one behind.
Another rule - fugitives shouldn't fall in love, especially with each other. A road isn't just a road, it's a trail, and Guidry's ruthless and relentless hunters are closing in on him. But now Guidry doesn't want to just survive, he wants to really live, maybe for the first time.
Everyone's expendable, or they should be, but now Guidry just can't throw away the woman he's come to love.
And it might get them both killed.
Anonymous 2 November 2018 at 04:30
You've got some interesting ones this time, Col. There are a few there (I'm thinking in particular of the Brassett) that sound good to me. I'll be interested in what you think of this lot when you get to it.
col2910 2 November 2018 at 08:31
Brassett's a new author to the stacks Margot. I'm looking forward to trying his work. The Berney and Pitts books are the other standouts for me.
TracyK 2 November 2018 at 20:52
Col, sorry I haven't been by lately. Work gets bad and then I can hardly find the energy for anything. I will catch up I hope.
I have one book by Lou Berney but haven't read it yet.
I hope your work situation improves soon Tracy.
I've heard good things about this particular Lou Berney book. I hope you enjoy the one you have.
Elgin Bleecker 6 November 2018 at 20:06
Most of these authors are new to me, Col. But Tom Pitts was already on my list.
Three of the authors are new to me and three have been read before including Tom Pitts.
Clothes In Books 14 November 2018 at 11:33
I loved one of Lou Berney's books, I think it was The Long and Faraway Gone, so looking forward to his new one: lucky you, I had seen it wasn't out here for ages!
Yes, I'm looking forward to it and hoping to get to it in the next month or so.
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ANONYMOUS-9 - THE 1ST SHORT STORY COLLECTION (2011...
LISA DOUGLASS (ed.) - SWITCHBLADE: STILETTO HEELED...
MARIETTA MILES - ROUTE 12 (2016)
2 BY MARGARET MILLAR
NANCI RATHBUN - HONOR KILLS (2018)
ELKA RAY - SAIGON DARK (2016)
MARGARET MILLAR - VANISH IN AN INSTANT (1952)
JENNY MORTON POTTS - HIDING (2018)
NOVEMBER 2018 - ADDITIONS TO THE LIBRARY - 6 OF TH...
2 BY MAUREEN CARTER
NIKKI DOLSON - ALL THINGS VIOLENT (2017)
CHRISTIANNA BRAND - GREEN FOR DANGER (1944)
BEV WILLIAMS - OLDER WISER SEXIER (2016)
CAROLE MORIN - SPYING ON STRANGE MEN (2012)
TESS GERRITSEN - WHISTLEBLOWER (1992)
2 BY ALISON BRUCE
WENDY CARTMELL - NO MERCY (2014)
CHRISTA FAUST - CHOKE HOLD (2011)
2 BY MARIETTA MILES
SIMON MALTMAN - THE SIDEWINDER (2018)
WALLACE STROBY - SOME DIE NAMELESS (2018)
EVA HUDSON - RUN GIRL (2014)
OCTOBER 2018 - FILMS + TV

redpajama_set_name: RedPajamaCommonCrawl


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redpajama_set_name: RedPajamaGithub


Leaving work it started to rain. I turned, intending to go back in and take the causeway to the parking garage. Save myself a drenching, I thought. As I turned, I felt the coolness of the air that was ushering in the rain caress my cheek. Just a second, really. It lingered upon my face, before my hand touched the door handle and I stopped to turn back into it. Fresh and full of that summer rain, which now dropped in big, slow drops upon my head.
Surely, I'll get wet walking to the car, I told myself. Hair will be a mess and you'll ruin this leather bag, said the always cautious, always organized part of my brain. Still, I couldn't resist the feeling. A curious intimacy of being touched by the weather, for it was a caress, of that I'm sure. A delicious taunting of a lover to come back to bed. The wind was begging me to stay. So I left the door closed and walked out into that summer rain and let myself fall in love.
This entry was posted in Flash Non-Fiction, spiritual thoughts and tagged adventure, art, attitude, awakening, beauty, blog, choices, cleansing, connection, divine, expansion, freedom, healing, letting go, light, living in the now, love, meditation, mindfulness, nature, photography, poem, rain, release, seeing our true beauty, self-love, spirit, spirituality, walking in the rain, Water, writer. Bookmark the permalink.
Lovely metaphor, lovely feeling, lovely that you came to visit.


After playing football in high school in a highly competitive environment, I don't react much to the "miked-up" sideline woofing among teammates that may sound outrageous, or to on-the-field out-of-view trash talk. Although mostly unrepeatable, these hidden-from-view verbal jousts were often hilarious. It's the "language of competition" to borrow a federal judge's phrase, referring to the (un)importance of the government's evidence regarding internal memos about a rival in an antitrust case.
But Holloway's POSTgame, public comments, after a historically ugly fight — that isn't just the language of competition. Moreover, it explicitly references the origin of the tensions — the "gangsters" mentality — or, at least, the silly faux-gangsta imitations seen in sports.
The incident draws attention to deep-seated issues and problems for decision makers in sports leagues. Whitlock calls out coaches who won't take a stand because of their greed, a theme repeated in many articles after short suspensions were handed out to the players. I'm not absolving coaches and admire the Oregon football coach who suspended LaGarrette Blount for the entire season after sucker-punching a Boise State player. However, coaches respond to incentives, and taking a unilateral stance that leads to fewer wins self-inflicts wounds far beyond the ethical threshold of most coaches, like it or not.
Higher level decision makers face similar, if not stickier dilemmas. Brian Phillips at Grantland.com explores these issues in an unrelated article focused on David Stern's leadership of the NBA.
In the past 15 years or so, the NBA has been haunted by a specter, one that began to coalesce around the advent of Allen Iverson before fully emerging in the wake of the Palace brawl. what he wanted by handing down a lot of petty decrees that — whatever the intention — came off as an attempt to make the NBA more palatable to white fans. … The problem is that you can't run a sports league on the premise that the players are the fans' natural enemies without undermining the compact that holds the sports league together in the first place. It's hard to reduce all the overlapping messages of the NBA's self-presentation over the past few years to one line, but if you tried, it would look something like: "Carmelo Anthony is spectacular! Buy a ticket and we'll put him in his place.
Phillips also deserves credit for at least mentioning that the fundamentals behind these issues are more complex than race. Michael Jordan, Jerry Rice, and many others past and present in the NBA and NFL were/are highly competitive players, are black, but in no way embodied or embraced the gangster silliness. It defines a sub-culture not an entire race.
The Xavier-Cincy brawl appalled more than "Red State" fans (Whitlock is no "Red Stater"). Yet, it comes from somewhere. The berating of the Cincy bench by Holloway and his post-game comments show that this didn't just emerge out of thin air. Yes, there have always been some fans put off by showy celebrations of some black players back to Billy "White Shoes" Johnson or to Dr. J's big afro. Holloway's comments speak to a different worldview, a different ethic, something not merely about good-natured exuberance or innocuous bits of self or cultural expression. They speak to neighborhood thugs as role model.
What about thuggish behavior in the NHL, does it get a pass? I've written about that before on TSE. It's a little different in that some fans want to see the fighting, but some of the issues overlap. Space limits a thorough discussion.


Just played twice yesterday. Great shape, wonderful course, but priced out of contention for repeat trips. Too bad.
Best greens, bar none, in the valley. Two short par fours back to back mar the layout, but otherwise a very good test. Best clubhouse in Invermere/Windemere area.
Great Course and is in great playing condition !
Every hole is a different type of challenge, and memorable at the same time.
If you are golfing in the area, you'd be foolish to miss Eagle Ranch. It is pristine, and the holes are memorable. There are maybe a few trees in the middle of fairways that could be considered gimmicky (and would not be missed if lightning happened to take them out) but in a largely touristy area of the valley you can say that about the other tracks too (Copper Point, Radium Springs, Greywolf, etc.) I highly recommend this course. Wish they would lower their prices a bit though.
Other than being the a little to expensive, it is without a doubt one of the nicest courses I have played on. Easy to see why it is ranked in the top ten Public courses in British Columbia.


Flaherty Sensabaugh Bonasso attorney Tom Flaherty was recently elected Chair of the West Virginia University Board of Governors, effective July 1.
A founding member of the firm, Tom has served on the Board of Governors since 2009.
Among the duties of the Board of Governors are the control, supervision and management of the financial business and education policies and affairs of West Virginia University.


JUVENTUS are under investigation by Uefa to see if they breached any regulations in their record deal to sign Cristiano Ronaldo, according to reports.
The Old Lady forked out £99million to land the Portuguese superstar in the blockbuster transfer of the summer.
Ronaldo was just one of their major additions with Juve forking out £217m in transfers including the likes of Douglas Costa and Joao Cancelo.
But Calcio Mercato report that the deals could come back to haunt them.
Juventus are set to come under the microscope by the governing body to see whether their spending was in line with the income they received.
The Italian champs would argue that they did balance the books after letting the likes of Mattia Caldara and Gonzalo Higuain leave the club.
Gianluigi Buffon's move to Paris Saint-Germain also meant the high earning Italian was taken off the wage bill.
Ronaldo's extraordinary wages will be called into question after agreeing a contract worth around £200,000-a-week on his four-year deal.
But they will be hoping the extra revenue raised by Ronaldo's signing including shirt sales, increase in ticket demand and a new television deal will help soften the blow.
Ronaldo finally kick-started his career in Serie A with his first goals for the club in a 3-0 win over Sassuolo at the weekend.


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Home / Publications / Corrections and correctional facilities as a public health setting in Canada
Corrections and correctional facilities as a public health setting in Canada
Author(s): Jami Neufeld
This document describes correctional facilities and regulations to protect incarcerated persons' health. We provide a rationale for the value and importance of public health services, in partnership and in addition to primary care for correctional facilities in Canada.
In the current coronavirus (COVID-19) pandemic context, there has been increasing attention to correctional facilities and other congregate settings as catalysts for infectious disease transmission. It is well known that infectious and other diseases are prevalent in correctional facilities around the world and Canada is no exception. Rachlis et al. discuss the importance of considering the broader environment and the role of social, structural, and environmental factors on transmission of infections, and we are learning that in the context of COVID-19, the necessity of real-time data and preventive health services, as well as a need for the broader and more holistic study of infectious disease transmission in correctional facilities.
The purpose of this paper is to consider incarceration, the movements of people in and out of facilities and communities, and the significance of these factors for infectious disease transmission, and to highlight correctional facilities as important settings for primary health and, particularly, public health partnerships and services. Correctional facilities as a significant setting for preventive and protective services contribute to fulfilling the obligations of government and health systems to support the health state of individuals who are incarcerated, as well as to support the health of communities where incarcerated individuals return.


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HOME Newsroom News Releases Orexigen and Takeda Announce an Amended and Restated Collaboration Agreement
Orexigen and Takeda Announce an Amended and Restated Collaboration Agreement
Partnership Reaffirms Commitment to the Success of CONTRAVE® (naltrexone HCl / bupropion HCl extended-release tablets)
San Diego and Deerfield, Ill., August 6, 2015 -- Orexigen Therapeutics, Inc. (Nasdaq: OREX) and Takeda Pharmaceutical Company Limited (TYO: 4502) today announced execution of an amended and restated collaboration agreement that resolves all outstanding disputes between the companies and aligns the partnership for the continued long-term success of CONTRAVE.
"CONTRAVE has quickly established itself as the most prescribed branded weight-loss medication in a rapidly growing market. Today, we have reaffirmed our commitment to the success of CONTRAVE in the United States," said Ramona Sequeira, President of Takeda Pharmaceuticals U.S.A., Inc.
"Takeda's market-leading share of voice through the sales organization, combined with the partnership's commitment to patient support, has enabled a strong launch and early results for CONTRAVE," said Mike Narachi, CEO of Orexigen. "We are pleased to have realigned our partnership and look forward to working closely with Takeda to deliver continued success for CONTRAVE in the United States."
Building awareness of the economic and health burden of obesity, and increasing patient access and coverage for anti-obesity medicines, are key areas of focus for the partnership. Takeda and Orexigen both support the Treat and Reduce Obesity Act of 2015 legislative initiative. The partners are committed to working together to educate the community on the need to reduce obesity in the United States.
About CONTRAVE
CONTRAVE, approved by the United States Food and Drug Administration in September 2014, is indicated for use as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of 30 kg/m2 or greater (obese), or 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus or dyslipidemia). Takeda Pharmaceuticals holds CONTRAVE rights in the U.S. where it commercializes the medicine. Orexigen retains full rights outside the United States including in Europe, where the medicine was approved in March 2015 with the brand name Mysimba™.
The exact neurochemical effects of CONTRAVE leading to weight loss are not fully understood. CONTRAVE has two components: naltrexone, an opioid antagonist, and bupropion, a relatively weak inhibitor of the neuronal reuptake of dopamine and norepinephrine. Nonclinical studies suggest that naltrexone and bupropion have effects on two separate areas of the brain involved in the regulation of food intake: the hypothalamus (appetite regulatory center) and the mesolimbic dopamine circuit (reward system).
Four 56-week multicenter, double-blind, placebo-controlled Phase 3 clinical trials were conducted to evaluate the effect of CONTRAVE in conjunction with lifestyle modification in 4,536 subjects randomized to CONTRAVE or placebo. In these studies, the most common adverse reactions (>5 percent) seen in patients taking CONTRAVE included nausea, constipation, headache, vomiting, dizziness, insomnia, dry mouth, and diarrhea.
WARNING: SUICIDAL THOUGHTS AND BEHAVIORS; AND NEUROPSYCHIATRIC REACTIONS
Suicidality and Antidepressant Drugs
CONTRAVE is not approved for use in the treatment of major depressive disorder or other psychiatric disorders. CONTRAVE contains bupropion, the same active ingredient as some other antidepressant medications (including, but not limited to, WELLBUTRIN, WELLBUTRIN SR, WELLBUTRIN XL, and APLENZIN). Antidepressants increased the risk of suicidal thoughts and behavior in children, adolescents, and young adults in short-term trials. These trials did not show an increase in the risk of suicidal thoughts and behavior with antidepressant use in subjects over age 24; there was a reduction in risk with antidepressant use in subjects aged 65 and older. In patients of all ages who are started on CONTRAVE, monitor closely for worsening, and for the emergence of suicidal thoughts and behaviors. Advise families and caregivers of the need for close observation and communication with the prescriber. CONTRAVE is not approved for use in pediatric patients.
Neuropsychiatric Reactions in Patients Taking Bupropion for Smoking Cessation
Serious neuropsychiatric reactions have occurred in patients taking bupropion for smoking cessation. The majority of these reactions occurred during bupropion treatment, but some occurred in the context of discontinuing treatment. In many cases, a causal relationship to bupropion treatment is not certain, because depressed mood may be a symptom of nicotine withdrawal. However, some of the cases occurred in patients taking bupropion who continued to smoke. Although CONTRAVE is not approved for smoking cessation, observe all patients for neuropsychiatric reactions. Instruct the patient to contact a healthcare provider if such reactions occur.
CONTRAVE is contraindicated in: uncontrolled hypertension; seizure disorder or a history of seizures; use of other bupropion-containing products; bulimia or anorexia nervosa, which increase the risk for seizure; chronic opioid or opiate agonist (eg, methadone) or partial agonists (eg, buprenorphine) use, or acute opiate withdrawal; patients undergoing an abrupt discontinuation of alcohol, benzodiazepines, barbiturates, and antiepileptic drugs; use during/within 14 days following treatment with monoamine oxidase inhibitors (MAOIs)—there is an increased risk of hypertensive reactions when CONTRAVE is used concomitantly with MAOIs and use with reversible MAOIs such as linezolid or intravenous methylene blue is also contraindicated; known allergy to any component of CONTRAVE anaphylactoid/anaphylactic reactions and Stevens-Johnson syndrome have been reported; pregnancy.
WARNINGS AND PRECAUTIONS
Suicidal Behavior and Ideation
All patients being treated with antidepressants for any indication should be monitored appropriately and observed closely for clinical worsening, suicidality, and unusual changes in behavior, especially during the initial few months of a course of drug therapy, or at times of dose changes, either increases or decreases. This warning applies to CONTRAVE because one of its components, bupropion, is a member of an antidepressant class.
Consideration should be given to changing the therapeutic regimen, including possibly discontinuing the medication, in patients whose depression is persistently worse, or who are experiencing emergent suicidality or symptoms that might be precursors to worsening depression or suicidality, especially if these symptoms are severe, abrupt in onset, or were not part of the patient's presenting symptoms.
Families and caregivers of patients being treated with antidepressants for major depressive disorder or other indications, both psychiatric and nonpsychiatric, should be alerted about the need to monitor patients for the emergence of anxiety, agitation, irritability, unusual changes in behavior, and other symptoms, as well as the emergence of suicidality, and to report such symptoms immediately to healthcare providers. Such monitoring should include daily observation by families and caregivers. Prescriptions for CONTRAVE should be written for the smallest quantity of tablets consistent with good patient management, in order to reduce the risk of overdose.
Neuropsychiatric Symptoms and Suicide Risk in Smoking Cessation Treatment
CONTRAVE is not approved for smoking cessation treatment, but serious neuropsychiatric symptoms have been reported in patients taking bupropion for smoking cessation. These have included changes in mood (including depression and mania), psychosis, hallucinations, paranoia, delusions, homicidal ideation, hostility, agitation, aggression, anxiety, and panic, as well as suicidal ideation, suicide attempt, and completed suicide. Observe patients for the occurrence of neuropsychiatric reactions. Instruct patients to contact a healthcare professional if such reactions occur.
CONTRAVE can cause seizures. The risk of seizure is dose-related. Discontinue treatment and do not restart CONTRAVE in patients who experience a seizure. Caution should be used when prescribing CONTRAVE to patients with predisposing factors that may increase the risk of seizure, including: history of head trauma or prior seizure, severe stroke, arteriovenous malformation, central nervous system tumor or infection, or metabolic disorders (eg, hypoglycemia, hyponatremia, severe hepatic impairment, and hypoxia); excessive use of alcohol or sedatives, addiction to cocaine or stimulants, or withdrawal from sedatives; patients with diabetes treated with insulin and/or oral diabetic medications (sulfonylureas and meglitinides) that may cause hypoglycemia; concomitant administration of medications that may lower the seizure threshold, including other bupropion products, antipsychotics, tricyclic antidepressants, theophylline, systemic steroids.
Clinical experience with bupropion suggests that the risk of seizure may be minimized by adhering to the recommended dosing recommendations, in particular: the total daily dose of CONTRAVE does not exceed 360 mg of the bupropion component (ie, four tablets per day); the daily dose is administered in divided doses (twice daily); the dose is escalated gradually; no more than two tablets are taken at one time; coadministration of CONTRAVE with high-fat meals is avoided; if a dose is missed, a patient should wait until the next scheduled dose to resume the regular dosing schedule.
Patients Receiving Opioid Analgesics
Vulnerability to Opioid Overdose: CONTRAVE should not be administered to patients receiving chronic opioids, due to the naltrexone component, which is an opioid receptor antagonist. If chronic opiate therapy is required, CONTRAVE treatment should be stopped. In patients requiring intermittent opiate treatment, CONTRAVE therapy should be temporarily discontinued and lower doses of opioids may be needed. Patients should be alerted that they may be more sensitive to opioids, even at lower doses, after CONTRAVE treatment is discontinued. An attempt by a patient to overcome any naltrexone opioid blockade by administering large amounts of exogenous opioids is especially dangerous and may lead to a fatal overdose or life-threatening opioid intoxication (eg, respiratory arrest, circulatory collapse). Patients should be told of the serious consequences of trying to overcome the opioid blockade.
Precipitated Opioid Withdrawal: An opioid-free interval of a minimum of 7 to 10 days is recommended for patients previously dependent on short-acting opioids, and those patients transitioning from buprenorphine or methadone may need as long as two weeks. Patients should be made aware of the risks associated with precipitated withdrawal and encouraged to give an accurate account of last opioid use.
Increase in Blood Pressure (BP) and Heart Rate (HR)
CONTRAVE can cause an increase in systolic BP, diastolic BP, and/or resting HR. These events were observed in both patients with and without evidence of preexisting hypertension. In clinical practice with other bupropion-containing
products, hypertension, in some cases severe and requiring acute treatment, has been reported. Blood pressure and pulse should be measured prior to starting therapy with CONTRAVE and should be monitored at regular intervals consistent with usual clinical practice, particularly among patients with cardiac or cerebrovascular disease and/or with controlled hypertension prior to treatment.
Anaphylactoid/anaphylactic reactions and symptoms suggestive of delayed hypersensitivity have been reported with bupropion, as well as rare spontaneous reports of erythema multiforme, Stevens-Johnson syndrome, and anaphylactic shock. Instruct patients to discontinue CONTRAVE and consult a healthcare provider if they develop an allergic or anaphylactoid/anaphylactic reaction (eg, skin rash, pruritus, hives, chest pain, edema, or shortness of breath) during this treatment.
Hepatotoxicity
Cases of hepatitis, clinically significant liver dysfunction, and transient asymptomatic hepatic transaminase elevations have been observed with naltrexone exposure. Patients should be warned of the risk of hepatic injury and advised to seek medical attention if they experience symptoms of acute hepatitis. CONTRAVE should be discontinued in the event of symptoms/signs of acute hepatitis.
Activation of Mania
Bupropion, a component of CONTRAVE, is a drug used for the treatment of depression. Antidepressant treatment can precipitate a manic, mixed, or hypomanic episode. The risk appears to be increased in patients with bipolar disorder or who have risk factors for bipolar disorder. Prior to initiating CONTRAVE, screen patients for history of bipolar disorder and the presence of risk factors for bipolar disorder (eg, family history of bipolar disorder, suicide, or depression). CONTRAVE is not approved for use in treating bipolar depression.
Angle-Closure Glaucoma
The pupillary dilation that occurs following use of many antidepressant drugs, including bupropion, may trigger an angle-closure attack in a patient with anatomically narrow angles who does not have a patent iridectomy.
Hypoglycemia with Use of Antidiabetic Medications
Weight loss may increase the risk of hypoglycemia in patients with type 2 diabetes mellitus treated with insulin and/or insulin secretagogues (eg, sulfonylureas). Measurement of blood glucose levels prior to starting CONTRAVE and during CONTRAVE treatment is recommended in patients with type 2 diabetes. Decreases in medication doses for antidiabetic medications which are non-glucose-dependent should be considered to mitigate the risk of hypoglycemia.
Most common adverse reactions (≥5%) include: nausea (32.5%), constipation (19.2%), headache (17.6%), vomiting (10.7%), dizziness (9.9%), insomnia (9.2%), dry mouth (8.1%), and diarrhea (7.1%).
Increased risk of hypertensive reactions can occur when CONTRAVE is used concomitantly with MAOIs. Use caution and consider dose reduction of drugs metabolized by CYP2D6 when using with CONTRAVE. Avoid concomitant use with CYP2B6 inducers. Reduce CONTRAVE dose when taken with CYP2B6 inhibitors. Dose CONTRAVE with caution when used with drugs that lower seizure threshold. Use caution and monitor for CNS toxicity when using CONTRAVE concomitantly with dopaminergic drugs (levodopa and amantadine). CONTRAVE can cause false positive urine test results for amphetamines.
CONTRAVE is indicated as an adjunct to a reduced-calorie diet and increased physical activity for chronic weight management in adults with an initial body mass index (BMI) of:
* 30 kg/m2 or greater (obese) or
* 27 kg/m2 or greater (overweight) in the presence of at least one weight-related comorbid condition (e.g., hypertension, type 2 diabetes mellitus, or dyslipidemia)
Limitations of Use
The effect of CONTRAVE on cardiovascular morbidity and mortality has not been established. The safety and effectiveness of CONTRAVE in combination with other products intended for weight loss, including prescription drugs and over-the-counter drugs, and herbal preparations, have not been established.
Please see accompanying full Prescribing Information and Medication Guide for CONTRAVE.
You are encouraged to report negative side effects of prescription drugs to the FDA. Visit www.fda.gov/medwatch, or call 1-800-FDA-1088.
Contrave® is a trademark of Orexigen Therapeutics, Inc. registered with the U.S. Patent and Trademark Office and used under license by Takeda Pharmaceuticals America, Inc. All other trademarks are the property of their respective owners.
About Orexigen Therapeutics
Orexigen Therapeutics, Inc. is a biopharmaceutical company focused on the treatment of obesity. Orexigen developed CONTRAVE® (naltrexone HCI and bupropion HCI extended-release), which is approved in the United States and is being commercialized there by the company's U.S. partner, Takeda Pharmaceuticals. In Europe, the drug has been approved under the brand name Mysimba™ (naltrexone HCI/bupropion HCI prolonged release). Orexigen's strategy for CONTRAVE/Mysimba is to pursue marketing authorizations worldwide and pharmaceutical partnerships for global commercialization. Further information about Orexigen can be found at www.orexigen.com.
About Takeda Pharmaceuticals U.S.A., Inc.
Based in Deerfield, Ill., Takeda Pharmaceuticals U.S.A., Inc. is a subsidiary of Takeda Pharmaceutical Company Limited, the largest pharmaceutical company in Japan. TPUSA markets oral diabetes, CNS, rheumatology and gastroenterology treatments. Its pipeline includes compounds for metabolic and cardiovascular disease,
gastroenterology, neurology and other conditions. To learn more, visit www.takeda.us.
About Takeda Pharmaceutical Company Limited
Located in Osaka, Japan, Takeda is a research-based global company with its main focus on pharmaceuticals. As the largest pharmaceutical company in Japan and one of the global leaders of the industry, Takeda is committed to strive towards better health for people worldwide through leading innovation in medicine. Additional information about Takeda is available through its corporate website, www.takeda.com.
Statements included in this press release that are not a description of historical facts are forward-looking statements. Words such as "believes," "anticipates," "plans," "expects," "indicates," "will," "should," "intends," "potential," "suggests," "assuming," "designed" and similar expressions are intended to identify forward-looking statements. These statements are based on the companies' current beliefs and expectations. These forward-looking statements include statements regarding the continued success for CONTRAVE in the United States.. Inclusion of forward-looking statements should not be regarded as a representation by the companies that any of their plans will be achieved. Actual results may differ materially from those expressed or implied in this release due to the risk and uncertainties inherent in the business, including, without limitation: the potential that the marketing and commercialization of Contrave will not be successful; the final results of the Light Study or the planned cardiovascular outcomes trial may not support continued approval of Contrave; additional analysis of the Light Study results or new data from the planned cardiovascular outcomes trial or other studies, including safety-related data, may produce negative or inconclusive results, or may be inconsistent with prior results; the therapeutic and commercial value of Contrave; increased competition within the anti-obesity market; Orexigen's failure to successfully acquire, develop and market additional product candidates or approved products; Orexigen's reliance on Takeda to vigorously enforce the CONTRAVE intellectual property rights; the potential for a Delaware court to determine that one or more of the patents are not valid or that Actavis' proposed generic product is not infringing each of the patents at issue; ; and other risks described in Orexigen's filings with the Securities and Exchange Commission. You are cautioned not to place undue reliance on these forward-looking statements, which speak only as of the date hereof, and the companies undertake no obligation to revise or update this news release to reflect events or circumstances after the date hereof. Further information regarding these and other risks is included under the heading "Risk Factors" in Orexigen's Quarterly Report on Form 10-Q to be filed with the Securities and Exchange Commission today and its other reports, which are available from the SEC's website (www.sec.gov) and on Orexigen's website (www.orexigen.com) under the heading "Investor Relations." All forward-looking statements are qualified in their entirety by this cautionary statement. This caution is made under the safe harbor provisions of Section 21E of the Private Securities Litigation Reform Act of 1995.
McDavid Stilwell
Corporate Communications and Business Development
Orexigen Therapeutics, Inc.
mstilwell@orexigen.com
David Walsey
BrewLife (Media Contact for Orexigen)
dwalsey@brewlife.com
Takeda Pharmaceuticals U.S.A., Inc.
Jeffrey Cross
Takeda Pharmaceutical Company Limited
Jeffrey.cross@takeda.com


In Season NOW: Butternut & Acorn Squash at your local Farmers Market!
To m e, this is the quintessential "Thanksgiving" dish. I find it satisfies a patriotic distant connection to our country's pioneers, as I imagine the residents of New Amsterdam (before it was New York) relishing the bounty of their New World.
I've daydreamed and developed this version of Squash Soup over many crisp autumn seasons. Its spicy aroma of pumpkin pie will fill the air but won't fill you up on an overloaded calorie count. And the dairy-free substitution of Coconut Milk instead of traditional cream and butter supplies an extra "Thanksgiving" for the Planet as well.
Cut Squash in half lengthwise and place cut side up on baking sheet along with the Yam and Garlic.
Bake 30 to 45 minutes until fork tender at 375 degrees.
Meanwhile, gently simmer the Onion, Cauliflower and Apple in large stockpot with 1/2 inch Water until tender.
Scoop flesh from baked Squash (avoid seeds), smash Yam, and add to pot with other veggies.
Squeeze in 3-5 roasted Garlic cloves from their skins and add Coconut Milk and Spices.
Use an Immersion Blender and puree to desired consistency, adding extra Coconut Milk or Water as you go.
Check and adjust Seasonings and Spices to taste. Re-heat, serve and enjoy!


text:
El Periodo Inex es un ciclo de eclipses de aproximadamente 29 años. El ciclo lo describió primero Andrew Crommelin en 1901, pero recibió su nombre de George van den Bergh, que lo estudió medio siglo después.

Un Inex tiene 358 lunaciones (mes sinódico) y su duración coincide con 388,5 meses draconíticos (D) o 30,5 año de eclipse. Esto significa que si hay un eclipse solar (o un eclipse lunar), entonces después de un inex una Luna Nueva (o una Luna Llena) tendrá lugar en el nodo lunar opuesto de la órbita de la Luna, y bajo estas circunstancias otro eclipse puede ocurrir.

Un Inex tiene una duración cercana a un número entero de días, 10.571,95 faltando sólo 70 minutos para completar el día. Por esta razón los eclipses solares tienden a tener lugar a sobre la misma longitud geográfica en los inex sucesivos, aunque en latitudes geográficas opuestas porque los eclipses ocurren en nodos opuestos. Esto entra en contraste con el conocido ciclo saros que tiene una duración de aproximadamente 6.585,32 días, de modo que los eclipses solares sucesivos tienden a ocurrir en longitud separadas 120° (aunque al ser en el mismo nodo si coincide la latitud geográfica).

Al contrario del Saros, el Inex no está cerca de un número entero de meses anomalísticos (A) así que los eclipses sucesivos no son muy similares en su apariencia y características. De hecho, a diferencia del Saros, una serie Inex puede fallar al principio y fin de una serie, y los eclipses pueden no ocurrir. Sin embargo una vez establecida, la serie inex es muy estable y funciona durante mucho tiempo.

Cuando un eclipse aparece en un periodo Saros, entonces un Inex antes hay un eclipse ya establecido de la serie Saros anterior. Los eclipses salientes de una serie saros y los nacientes están relacionados mediante el periodo Inex de 29 años con eclipses ya establecidos de un Inex posterior o anterior respectivamente. Naturalmente que siendo eclipses que transcurren con diferencia de un Inex conservan dicho número.

Ejemplos
El 1 de julio de 2011 hubo un débil eclipse de Sol en el hemisferio sur que fue el primero de la serie Saros 156, un inex antes el 20 de julio de 1982 hubo un eclipse parcial de magnitud 0,465 de la serie Saros 155 que anunciaba el nacimiento del nuevo eclipse. Ambos eclipses tienen un Inex 21.

El eclipse solar del 22 de julio de 1971 fue el último que desapareció de una serie Saros, exactamente de la serie S=116 y un Inex después el eclipse de Sol del 1 de julio de 2000, caracterizado por ser de la serie Saros 117 y con magnitud 0,477 nos recuerda la muerte del eclipse de 1971. Ambos eclipses tienen un Inex 83.

El próximo eclipse en desaparecer de una serie Saros lo será la serie S=117 y ocurrirá el 3 de agosto de 2054. El nacimiento y muerte de eclipses en los periodos Saros no está compensado y el periodo Saros cambia el número de eclipses, actualmente los Saros son pobres y aún irán a peor, pero luego se recuperaran para estar en su media y luego superarla, todo ello con un ciclo de unos 600 años.

Intervalo entre dos eclipses
La importancia del ciclo del inex no está en la predicción, sino en que cualquier ciclo de eclipses, y de hecho el intervalo entre dos eclipses cualquiera, se puede expresar como una combinación de Saros e Inex. G. van den Bergh demostró que el intervalo de tiempo T en días entre dos eclipses solares o lunares puede hallarse con una fórmula sencilla:

donde  es el periodo Inex de 10 571,95 días y  es el periodo Saros de 6585,32 días y  son dos números enteros.

Véase también
 Saros

Eclipses

redpajama_set_name: RedPajamaWikipedia


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text:
Stefan Poznański (ur. 5 stycznia 1922 w Rzezawie, zm. 8 stycznia 1982 w Olsztynie) – polski działacz partyjny i akademicki, poseł na Sejm PRL VII i VIII kadencji (1976–1982). Budowniczy Polski Ludowej.

Życiorys
W czasie okupacji pracował na roli, w 1942 przebywał w obozie karnym Kraków-Dąbie. Po wojnie pracował w Śląskich Zakładach Mleczarskich. W 1950 podjął studia w Wyższej Szkole Rolniczej w Olsztynie, które kontynuował w Szkole Głównej Gospodarstwa Wiejskiego w Warszawie. Uzyskał tytuł profesora doktora habilitowanego nauk technicznych, z zawodu był inżynierem chemii i technologii żywności. Ukończywszy studia w 1953, związał się z WSR, gdzie pełnił funkcję dziekana, a następnie prorektora.

W Polskiej Zjednoczonej Partii Robotniczej działał od 1955. Dwukrotnie pełnił funkcję I sekretarza KU PZPR, trzykrotnie członka egzekutywy KU, dwukrotnie członka plenum KM w Olsztynie, a dwukrotnie zastępcy członka plenum KW PZPR w Olsztynie. Zasiadał też w Komisji Rolnej KC. Był członkiem korespondentem Polskiej Akademii Nauk od 1976, członkiem Prezydium Komitetu Technologii i Chemii Żywności PAN, a także przewodniczącym Krajowej Rady Wynalazczości i Racjonalizacji Rady Głównej NOT.

Był wybitnym specjalistą w zakresie technologii żywności, zasłużonym wynalazcą oraz w 1974 laureatem I nagrody Ogólnopolskiego Konkursu o tytuł "Mistrza Racjonalizacji".

W 1976 i 1980 uzyskiwał mandat posła na Sejm PRL VII i VIII kadencji w okręgu Olsztyn. Podczas obu kadencji zasiadał w Komisji Nauki i Postępu Technicznego i Komisji Rolnictwa i Przemysłu Spożywczego, której był zastępcą przewodniczącego. Zmarł w trakcie kadencji, pochowany na cmentarzu komunalnym w Olsztynie.

Odznaczenia
 Order Budowniczych Polski Ludowej (1974)
 Krzyż Kawalerski Orderu Odrodzenia Polski
 Odznaka tytułu honorowego "Zasłużony Nauczyciel Polskiej Rzeczypospolitej Ludowej"
 Medal 10-lecia Polski Ludowej (1955)

Przypisy

Bibliografia
 Profil na stronie Biblioteki Sejmowej

Absolwenci Szkoły Głównej Gospodarstwa Wiejskiego
Członkowie Komisji Komitetu Centralnego PZPR
Członkowie Komitetów Miejskich PZPR
Członkowie Komitetu Wojewódzkiego PZPR w Olsztynie
Członkowie korespondenci PAN
Pochowani na Cmentarzu Komunalnym w Olsztynie
Odznaczeni Krzyżem Kawalerskim Orderu Odrodzenia Polski (Polska Ludowa)
Odznaczeni Medalem 10-lecia Polski Ludowej
Odznaczeni odznaką tytułu honorowego "Zasłużony Nauczyciel PRL"
Odznaczeni Orderem Budowniczych Polski Ludowej
Pierwsi sekretarze Komitetów Uczelnianych PZPR
Posłowie z okręgu Olsztyn (PRL)
Urodzeni w 1922
Zmarli w 1982
Ludzie urodzeni w Rzezawie


Even the most bullish stock market fan has to admit one thing. And that's the fact that the U.S. economy is no longer a spring chicken.
After nearly a decade of expansion, we certainly aren't at the beginnings of growth. Data is still good, but not nearly as great as just a few quarters ago. This certainly throws investors for a loop in building and adjusting their portfolios.
How can you get good returns this late in the game?
Luckily, there are some ways to pivot your holdings based on where we are in the business cycle. By using sector rotation, we can still profit as the economy goes through its paces.