Adding to this site's archived case summaries addressing advocacy by expert witnesses, reasons for judgement were released today by the BC Supreme Court, Vancouver Registry, soundly criticizing an expert witness for a lack of objectivity.
In today's case (La Porte v. Earl) the Plaintiff was involved in a 2010 collision that the Defendant admitted fault for. She suffered physical and psychiatrist injuries as a result of the crash. In the course of the crash the Defendant's insurer sent her to a psychiatrist who marginalized any psychiatric injuries she had and their connection to the collision.
 After careful consideration I have concluded that I can give no weight to Dr. Levin's report. There are a number of reasons why I have reached this conclusion. I begin by saying that I found that Dr. Levin's report lacked objectivity. It seemed to me that Dr. Levin was marshalling evidence in favour of his conclusion, rather than attempting to communicate constructively with Ms. La Porte to determine her actual mental state.
 Dr. Levin developed a number of themes that he repeated throughout his report. One such theme was to emphasize how resilient Ms. La Porte had been before the Accident, and to extrapolate that resilience into her reaction to the pain and anxiety that she experienced after the Accident.
 At the outset of his opinion, Dr. Levin referred to Ms. La Porte's pre-accident condition and began by emphasizing that Ms. La Porte did not present with any biological or psychological vulnerabilities that would have predisposed her to the development of any psychiatric illness.
 The foregoing summary is at marked variance to Ms. La Porte's evidence in court that she struggled with the heavier physical demands of her job and the physical exertions of her job significantly worsened her pain. In addition, given Ms. La Porte's evidence in court, which I have accepted, about the circumstances of her last day of work, I can only conclude that Dr. Levin did not inquire about those circumstances.
 There were two portions of Dr. Levin's evidence that I found particularly problematic. The first relates to this sentence at page 5 of the report: "Ms. La Porte indicated that she went on a medical leave in anticipation (not yet experienced) of having an increased workload in the fall of this year that could affect her physical problems." When Dr. Levin was asked in cross-examination whether he had italicized the word "could" in this portion of his report to emphasize that there was no actual effect on Ms. La Porte's physical problems, he denied that intent and stated that the italics were a clerical error. I find this answer to be lacking in credibility. In the context of the rest of that portion of his report, it is obvious that Dr. Levin was emphasizing that Ms. La Porte had not yet experienced any difficulty in coping with her work at the time she stopped working.
 In addition, Dr. Levin implies in this passage that Ms. La Porte had not reported any effect that her job had on her physical problems. It is unclear whether he is suggesting she denied any negative effects or whether he based this statement on Ms. La Porte not volunteering any such information. If she told him that her job had no negative effects on her physical problems, it would have been contrary to what she told the other doctors who examined and treated her, as well as to her evidence before me, which I have accepted as credible. I therefore think it is highly unlikely that she denied any negative effects. I note that Dr. Levin did not indicate that he asked any questions about this subject in his interview of Ms. La Porte.
It seems one of the major issues identified in Ms. La Porte's case is reportedly, "Legal proceedings to get some compensation as she was the injured party…" However, Dr. Oluyede does not discuss any specific psychiatric or psychological injury sustained in the subject MVA that would require any compensation.
Three days later she noticed an increasing pain in her right leg and her right arm. She described the pain as spasmodic. On the day of the accident she was seen in emergency and had been medically cleared.
Following this she has had subsequent issues with pain and has seen a chiropractor for a while. Both car insurance companies have been involved and her car has been fixed. She took four days off of work at that time.
Presently she is going through legal proceedings to get some compensation as she was the injured party and has been incapacitated since the accident.
She describes not feeling good most of the time, feeling easily stressed out and overwhelmed. She has had to cut down her hours of work from forty hours previously per week to thirty-five hours.
She has noticed a continuous decline in both her physical and mental health. With regards to her mental health she describes easy fatigability, worry and anxiety about her future and with regards to finances. She describes feeling drained most of the time and has noticed that on certain occasions she does have what she describes as overwhelming anxiety.
 In my view, Dr. Levin did not accurately or fairly paraphrase Dr. Oluyede's consultation report. Even more problematically, when Dr. Levin was cross-examined on the above passage from his report, he again said this was either a typographical error or he misspoke himself in his dictation and meant to say "assistance" not compensation. Again, given the context of the passage, in which Dr. Levin seems to be at pains to show that Ms. La Porte is seeking compensation, I cannot accept this explanation from him.
 In addition, I found Dr. Levin to be argumentative and somewhat non-responsive in the answers he gave in cross-examination. Finally, I am concerned that Dr. Levin had some animus towards Ms. La Porte. At the outset of his notes on his interview with Ms. La Porte he recorded that he felt she was being unreasonable and uncooperative with him. None of the other doctors who conducted independent medical examinations at the request of the defendants made any such comment.
 I therefore give no weight to Dr. Levin's opinion in this matter.
This entry was posted on Friday, December 9th, 2016 at 2:37 pm	and is filed under Uncategorized. Both comments and pings are currently closed.


Please, Go Here. Read This.
From The Errant Aesthete. There are tidbits of elegance scattered about this post like so many dark chocolates, waiting to be ingested, exclaimed upon and savoured.
This entry was posted in Elegantology and tagged Sir Hardy Amies, The Errant Aesthete. Bookmark the permalink.
4 Responses to Please, Go Here. Read This.
Oh, now that was positively dreamy. I adore Hardy.
….and this is just another reason to ' totally love you ' today !
I'm not surprised that Hardy's life, manner and model of living might resonate with you. He strikes me as one of those guests you'd like to have gathered around the bar tray, leaving you grateful for simply being in the room.
let the whole world in on the secret.
Errant Aesthete, I would feel like a guest at one of my own parties — the ultimate treat. It was a pleasure to point a few people your way. As you say "How can one not be elevated by style, wit, intelligence, class and propriety. And the bons mots – priceless!" The post was a joy to read, too.


text:
Q: Error in stateflow I have a problem, when I am running my model.
The error is:

Error reported by S-function 'sf_sfun' in
  'duo/Subsystem2/Genset1/Primover and generator/Electrical system/
  SFunction ': Stateflow Suppress Error.

failed assertion in .\utils\object.cpp at line 2850:    object[id]!=NULL
    Stack Trace:   [  0] 000000018000DCC4                libut.dll+056516
    (MathWorks::I18N::Utf8String::clone+000260)   [  1] 0000000180010E6C
    libut.dll+069228 (utDumpStackTrace+000492)   [  2] 0000000041A52615
    sf.mexw64+2631189 (dd::DDException::~DDException+004277)   [  3]
    0000000041B7E7F8                sf.mexw64+3860472
    (TagVisitorTraverserSF::`vftable'+478424) MATLAB m-file stack trace:

In stateflow\private\get_sf_block_port_info at 8

When I am opening the function get_sf_block_port_info I am getting this function
    function portInfo = get_sf_block_port_info(sfunId,varargin)

% Copyright 2003-2004 The MathWorks, Inc.

blockId = get_param(sfunId, 'parent');
chartId = block2chart(blockId);
try
    portInfo = sf('Cg','get_chart_port_info',chartId,varargin{:});
catch
    portInfo = [];
end

I tried to change varargin{:} to do it varargin, but I cannot make any changes.

redpajama_set_name: RedPajamaStackExchange


text:
Francis Boyle (born 1950) is an American professor of international law at the University of Illinois.

Francis Boyle may also refer to:
 Francis Boyle, 1st Viscount Shannon (1623–1699), Privy Counsellor of Ireland
 Francis J. Boyle (1927–2006), U.S. federal judge
 Frank Boyle (born 1945), Democratic Party member of the Wisconsin State Assembly
 Frankie Boyle (born 1972), Scottish comedian

redpajama_set_name: RedPajamaWikipedia


Exploring the United States in an RV is the perfect way to enjoy the best parks, sites, and destinations our country has to offer. Don't just take our word for it, check out the itineraries below to see how a few of the contributors from our blog, The Scenic Route, get the most out of their RV trips.
Do you dream of escaping the daily hustle and bustle and retreating into a lush island paradise where enjoying a slow, mindful life is the norm? If so, join Just 5 More Minutes and say hello to the San Juan Islands of Washington State here.
Moab is a town that will always have Making Sense of Cents' heart. This small town in Eastern Utah, with a population of only around 5,000 people, has spectacular views and countless things to do. See how to make the most of a trip here.
After exploring 49 states, the Newschool Nomads have plenty of places to choose from when giving travel recommendations. The one that is constantly at the top of their list because of the variety of activities is the Black Hills in South Dakota. See why the mix of history and indoor/outdoor activities makes it a frequent travel spot here.
When most people think about Southern California, a camping adventure isn't what comes to mind, but Shore Looks Nice knows traveling by RV is the best way to experience the California Dream. Check out an hour-by-hour guide on how it can be done here.
Fancy Gap, Virginia may barely be four square miles, but RV Family Travel Atlas thinks it's the perfect base camp for exploring nearly 500 miles of small towns, national parks, and a little Hollywood nostalgia. See how you can experience it for yourself here.
It may only be accessible for part of the year, but Shore Looks Nice thinks that is part of Glacier National Park's appeal. See why this spectacular national park is one of their favorite destinations for hiking, biking, and breathtaking views here.
The Outer Banks Perfect for sand, sea, and sightseeing – Use this detailed guide by Newschool Nomads to Go RVing to the gorgeous Outer Banks of North Carolina See how you can experience it for yourself here.
The Road to Adventure knows the best way to travel The Grand Circle is by RV. See her itinerary for a step-by-step trip through four separate states, ten national parks, and more breathtaking views than you can count here.
For some, the Midwest doesn't come to mind as one of the first places to Go RVing, but Newschool Nomads think it should definitely be on your list. Discover the hidden gems of Door County, Wisconsin with their detailed trip itinerary here.


The idea of packing a Hellcat engine into every vehicle it can find is the equivalent of FCA working to stick a coin in every slot it can find. Most recently, the Jeep brand brought a new Grand Cherokee to the market with the Hellcat. This new Grand Cherokee is called the Trackhawk for a reason. Most of the Jeep models you see are Trail Rated, this one has a different way of handling its business. That is by being Track Rated and ready to turn some fast laps for you to enjoy.
What Makes the Trackhawk a Track Rated Model?
When you think of a Jeep model that gives you more; that more is usually in the form of trail performance, but the Trackhawk is a different animal. Powered by the massive 6.2-liter supercharged Hellcat V8 engine that produces 707 horsepower. This is not a model that's advertised for trails. Besides that, this SUV can get out and go on the trails in order to give you more of the fun you want in the outdoors, but this SUV is made to handle the fun on the track.
Not only is the Trackhawk powered by an incredible engine, but it also has the suspension and drives system to make this impressive vehicle that can be excellent for you to take a drive. This Jeep is one that's made to reach sixty mph in only 3.3 seconds and rip off the quarter-mile in as little as 11.6 seconds to offer you the sprinting performance you want to enjoy. This SUV may be built to handle rocks and trees in the wilderness, but its easily one of the fastest on the market as well.
You're going to be able to scream down the road or experience some seriously fast laps on the track with the Trackhawk. Still, this is a Jeep Grand Cherokee. Because of this, the Trackhawk is a vehicle that brings you the qualities you're looking for and the drive you need in order to have a livable experience with your family. This SUV can seat five people comfortably, gives you the roominess you're looking for, and makes it possible for you to enjoy the drive every single day.
During the week, the Jeep Grand Cherokee Trackhawk is a mild-mannered and easy to experience a vehicle that shows up and performs the way you want every day. At the end of the week, you can take this SUV out for a great ride and let it loose on the track to give you the fun and powerful drive you're looking for. You didn't buy a vehicle with over 700 horsepower to let it be a commuter vehicle; let the Hellcat loose and make the Trackhawk show you what it can do when you take it out on the track for a drive.


"Dear 'Welfare-Cheater' Acuser, You have the wrong house. My wife and I are both hard-working young people who do not receive any money, or food, or anything else from the government. Stop leaving notes in our door. Thank you."
One of the better signs I've found around town. I would have loved to have seen and read the notes that were left at the house for the supposed welfare-cheaters. This sign should be partnered with the "Pooper-Law" sign I found on South 9th Street in my neighborhood. People in South Philly know how to say it like it is!


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text:
Blink and You'll Miss it: Rare Flower Blooms Only Once in Years
Home /Lifestyle, Recent Posts/Blink and You'll Miss it: Rare Flower Blooms Only Once in Years
Dhruvika Singh
Dhruvika writes on sustainable practices in various sectors for BuzzOnEarth. Get in touch with her at dhruvika@buzzonearth.com. Sometimes she reads her emails too.
Lifestyle,Recent Posts |
Watch it closely, one night of careless sleep and you won't see it for the next few years. Saussurea obvallata, commonly known as Brahma Kamal, is one of the most mystical and beautiful flowers on the planet. It comes to life only once in a couple of years and its bloom lasts for a couple of hours although legend has it that it only blooms once in 14 years. Its a magical flower isn't it?
Image: Flickr
The name Brahma Kamal has its origins in Indian mythology. Brahma, the Indian God of Creation holds a lotus flower in one of his four hands and he also sits in a lotus, the national flower of India. Quite contrary to its appearance, the Brahma Kamal is not a lotus but a type of cactus.
The flower only blooms at night and has a spell bounding fragrance because it is in a hurry to attract its pollinators at night. The phenomenon, often described as spiritual and sacred, takes place around July and August.
Generally found in the Himalayas, the flower has numerous name, Queen of the Night, Lady of the evening, Night Blooming Cereus. It is also the state flower of the Indian state, Uttarakhand.
In India, the Brahma Kamal is believed to be a sacred plant. It's such a rarity to see the flower that rumours has it that the one who sees the flower bloom will have all of his wishes come true. The flower is also believed to bring luck and prosperity to the house where it blooms.
Apart from its beauty and grace, Brahma Kamal also has use in medicine. In Tibetan medicine, it is used as a medicinal herb.
Image: Wikimedia Commons
If you are hyped to have this magnificent plant in your kitchen garden, the plant grows from cuttings and must be planted before winter. Cold weather is best suited for its optimal growth. Use highly fertile soil and water the plant once in two-three days. It's a cactus, you really wouldn't wanna end up it being dead from waterlogging.
And the last and the most important thing is to keep an eye on it, especially at night around 10 pm. Make sure you wouldn't miss the magical phenomenon. It's hard work for sure, but then that adds up to its rarity and exclusivity and makes it even more gorgeous than it appears to be!
A Marine Highway for Sharks
All Things Aesthetic

redpajama_set_name: RedPajamaCommonCrawl


They both have been sending fine until today. Helpful +30 Report Steve Apr 5, 2009 10:42PM I as well had the same problem using two seperate gmail accounts through Outlook 2007. It would just get stuck in the Outbox for ever. This Site Has Been Hacked CyanogenMOD 12.1 UNOFFICIAL ALPHA2 What idiot would make a device camera without a flash??
Instead it has a dropdown box where you select SSL". The system returned: (22) Invalid argument The remote host or network may be down. I use AT&T at home.and beginning today at work. Made one 25 and the other 465 and now they work, for now.
Search Search titles only Posted by Member: Separate names with a comma. View all 8 comments Report Nilanjan- Mar 18, 2009 01:49PM Sorry...forgot to mention that I used 587 (in stead of 465) as SMTP port. thanks Report Roy- Dec 29, 2009 08:28PM Vijay is right. Corrected it and works as it should.
Hope this helps you guys.Click to expand... Don't forget to click Save Changes when you're done. I have checked the Outgoging Server settings, and the SMTP server and port are correct. Click Finish.
http://mail.google.com/support/bin/answer.py?answer=76147 Helpful +3 Report whizzed Jun 11, 2009 04:05AM A lot of the problems stem from your ISP IMAP is best to use. I removed the "moto-android." from both the outgoing and incoming servers and it worked the first time! finally got gmail up and going.. As soon as I changed them both I have the ability to send out emails from any of my accounts.
Jasi have you tested your mails like I did? PS 2 : I'm using different mail server for incomming and outgoing and this works fine as long as this additional marking is no issue which might create confusion Helpful +1 But the problem is not able to send mail from outlook. You're done configuring your client to send and retrieve Gmail messages.
Report Magz- Jan 25, 2013 10:02AM This worked for me!!!!!!!! Being a member gives you additional options. Could only snd via Webmail. I changed the outgoing port to 25 after seeing this post and the problem was resolved.
Report Kix- Aug 3, 2009 05:51PM Thank you!! Log in or Sign up Forums News Help Android Forums Forums > Android Phones > Motorola Droid X > Authentication error sending...Support Last Updated: Jun 26,2012 waldo1963 New Member This Topic's I use Netfirms for our e-mail server, and they confirmed that the Droid X does not support their authentication requirements... Try K9 email client.
Good luck!! When you get there, go to properties. Go to your Google account settings and click security, then turn off the 2-step verification, you will be asked for your password. Just change Outgoing SMTP 465 to 587.
Being a member gives you detailed monitoring of your requests. Turns out the new ISP (O2 broadband) blocks port 25. Jan 20, 2011 #4 atlantafalcon New Member Joined: Feb 1, 2011 Messages: 1 Likes Received: 1 ginapbrad said: ↑ After banging my head on this one for a while I noticed settings I configured id : POP3 - in.pop.mail.yahoo.com SMTP -in.smtp.mail.yahoo.com More seetings->outgoing tab ->click " my outgoing server require authentication" and "use same settings as my incoming mail server".
Helpful +4 Report vijay Mar 8, 2009 12:45AM hi friends, i was also facing same prob. I can't seem to set a different username/password for each server. I have not been able to send ANYTHING out for the longest time now. New to app development ZW2 Messaging Issue How to upgrade Galaxy Note 5 to Android 2.1 or higher?
settings I configured id : POP3 - in.pop.mail.yahoo.com SMTP -in.smtp.mail.yahoo.com More seetings->outgoing tab ->click " my outgoing server require authentication" and "use same settings as my incoming mail server". However, this was fixed by changing the recommended Outgoing SMTP port from 465 to 587. Report inanc- Dec 11, 2008 08:18PM i have a similar problem as Jasi port numbers I have tried different versions for the outgoing mail server. (25 on auto, 465 on SSL Thanks to the OP for the information.
Android Forums Forums > Android Phones > Motorola Droid X > Forums Forums Quick Links Recent Posts New Posts All New From Favorites Register My Forums My Posts Advanced Search Resources Report chronk- Apr 30, 2010 03:43PM Port 25 was blocked for me - so I used Port 465 as SMTP port and checked SSL.


Kitchen genius Kenwood engages the Chaos team to differentiate customers' cooking experiences.
Kenwood kMix could not afford to position itself too firmly as a 'serious foodie' brand as this would have alienated those who were simply looking for a co-ordinating kettle, toaster or coffee maker.
The 'Be Yourself' proposition statement needed to balance intrinsically feminine values with unisex or masculine imagery.
'Be Yourself' needed to be used with care to reflect individuality and avoid any connotations of lacking assertiveness, self-identity or authenticity.
We delivered a series of posters and print ads, landing page design, social ads and social branding, Point of Sale (POS) assets, and digital display ads as part of the campaign.
Chaos created the sub-brand identity for My Chef. The proposition 'My Chef, My Way' is aimed at home-cooking; focusing on cooking food your way. It's about being proud of what you made at home.
The campaign also focuses on the versatility of products where there are different attachments to swap and change - enabling you to create a range of foods such as ice cream, pasta, etc.
Assets delivered as part of this campaign were: My Chef sub-brand identity, photoshoot, production of animation video, series of posters and print ads, social ads and social branding, paid social campaign, digital display ads and a landing page.


text:
Registration for Event Closes on March 20th
Published on March 14th, 2018 7:29 pm EST
Earlier today, Poker Central and the ARIA announced that registration for the Super High Roller Bowl is going to close on March 20th.
There will be a total of 30 spots available to the general public, while another 18 seats will go to ARIA "VIP guest" entrants.
Assuming that more than 30 players put down a $30,000 deposit, there will be a lottery on March 21st to see who gets to play in the tournament, as the number of open seats will be limited to 30. This lottery will be streamed for free on PokerGo.
The buy-in for the tournament, which will run from May 27th to May 30th, is $300,000. The total prize pool is expected to top $14 million, with the eventual winner of the event walking away with an estimated $5 million.
This will be the fourth year that the Super High Roller Bowl has been held.
The first Super High Roller Bowl, which had a buy-in of $500,000, was won by Brian Rast and had a total of 43 entrants.
The next year (2016), the buy-in was cut down to $300,000. A total of 49 players turned out for the event, which created a total prize pool of $15 million. The event was won by Rainer Kempe ($5 million), while Fedor Holz finished in second place.
Last year (2017), a total of 56 players paid the $300,000 to enter the event. For the second year in a row, a German player took down the event, as Christoph Vogelsang ended up winning the first place prize of $6 million.
While the field this year is limited to 48 players, there is always a chance that more players could be allowed in if the demand is high enough.
Source: PokerCentral.com - Super High Roller Bowl Registration Closes March 20, Live Lottery on PokerGo March 21


Demand for fuel assistance is up; Emergenccy 911 service disrupted; Health survey planned for this fall; and commentator Bill Seamans is disappointed with the new G.I Bill.
Vermont's Enhanced 911 program is expanding its program to receive emergency texts because state officials say the first phase of this pilot project has been very successful.
State officials who run the state's emergency call system say a new web-based program will allow people to call for help with a simple text message or video.


text:
//
// This file was generated by the JavaTM Architecture for XML Binding(JAXB) Reference Implementation, v2.2.4-2
// See http://java.sun.com/xml/jaxb
// Any modifications to this file will be lost upon recompilation of the source schema.
// Generated on: 2014.09.07 at 08:01:35 PM IST
//

package com.mozu.qbintegration.model.qbmodel.allgen;

import javax.xml.bind.annotation.XmlAccessType;
import javax.xml.bind.annotation.XmlAccessorType;
import javax.xml.bind.annotation.XmlElement;
import javax.xml.bind.annotation.XmlRootElement;
import javax.xml.bind.annotation.XmlType;

/**
 *
Java class for anonymous complex type.
 *
 *
The following schema fragment specifies the expected content contained within this class.
 *
 *

 * <complexType>
 *   <complexContent>
 *     <restriction base="{http://www.w3.org/2001/XMLSchema}anyType">
 *       <sequence>
 *         <element ref="{}AccountingPreferences" minOccurs="0"/>
 *         <element ref="{}FinanceChargePreferences" minOccurs="0"/>
 *         <element ref="{}JobsAndEstimatesPreferences" minOccurs="0"/>
 *         <element ref="{}MultiCurrencyPreferences" minOccurs="0"/>
 *         <element ref="{}MultiLocationInventoryPreferences" minOccurs="0"/>
 *         <element ref="{}PurchasesAndVendorsPreferences" minOccurs="0"/>
 *         <element ref="{}ReportsPreferences" minOccurs="0"/>
 *         <element ref="{}SalesAndCustomersPreferences" minOccurs="0"/>
 *         <element ref="{}SalesTaxPreferences" minOccurs="0"/>
 *         <element ref="{}TimeTrackingPreferences" minOccurs="0"/>
 *         <element ref="{}CurrentAppAccessRights" minOccurs="0"/>
 *         <element ref="{}ItemsAndInventoryPreferences" minOccurs="0"/>
 *       </sequence>
 *     </restriction>
 *   </complexContent>
 * </complexType>
 *

 *
 *
 */
@XmlAccessorType(XmlAccessType.FIELD)
@XmlType(name = "", propOrder = {
    "accountingPreferences",
    "financeChargePreferences",
    "jobsAndEstimatesPreferences",
    "multiCurrencyPreferences",
    "multiLocationInventoryPreferences",
    "purchasesAndVendorsPreferences",
    "reportsPreferences",
    "salesAndCustomersPreferences",
    "salesTaxPreferences",
    "timeTrackingPreferences",
    "currentAppAccessRights",
    "itemsAndInventoryPreferences"
})
@XmlRootElement(name = "PreferencesRet")
public class PreferencesRet {

    @XmlElement(name = "AccountingPreferences")
    protected AccountingPreferences accountingPreferences;
    @XmlElement(name = "FinanceChargePreferences")
    protected FinanceChargePreferences financeChargePreferences;
    @XmlElement(name = "JobsAndEstimatesPreferences")
    protected JobsAndEstimatesPreferences jobsAndEstimatesPreferences;
    @XmlElement(name = "MultiCurrencyPreferences")
    protected MultiCurrencyPreferences multiCurrencyPreferences;
    @XmlElement(name = "MultiLocationInventoryPreferences")
    protected MultiLocationInventoryPreferences multiLocationInventoryPreferences;
    @XmlElement(name = "PurchasesAndVendorsPreferences")
    protected PurchasesAndVendorsPreferences purchasesAndVendorsPreferences;
    @XmlElement(name = "ReportsPreferences")
    protected ReportsPreferences reportsPreferences;
    @XmlElement(name = "SalesAndCustomersPreferences")
    protected SalesAndCustomersPreferences salesAndCustomersPreferences;
    @XmlElement(name = "SalesTaxPreferences")
    protected SalesTaxPreferences salesTaxPreferences;
    @XmlElement(name = "TimeTrackingPreferences")
    protected TimeTrackingPreferences timeTrackingPreferences;
    @XmlElement(name = "CurrentAppAccessRights")
    protected CurrentAppAccessRights currentAppAccessRights;
    @XmlElement(name = "ItemsAndInventoryPreferences")
    protected ItemsAndInventoryPreferences itemsAndInventoryPreferences;

    /**
     * Gets the value of the accountingPreferences property.
     *
     * @return
     *     possible object is
     *     {@link AccountingPreferences }
     *
     */
    public AccountingPreferences getAccountingPreferences() {
        return accountingPreferences;
    }

    /**
     * Sets the value of the accountingPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link AccountingPreferences }
     *
     */
    public void setAccountingPreferences(AccountingPreferences value) {
        this.accountingPreferences = value;
    }

    /**
     * Gets the value of the financeChargePreferences property.
     *
     * @return
     *     possible object is
     *     {@link FinanceChargePreferences }
     *
     */
    public FinanceChargePreferences getFinanceChargePreferences() {
        return financeChargePreferences;
    }

    /**
     * Sets the value of the financeChargePreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link FinanceChargePreferences }
     *
     */
    public void setFinanceChargePreferences(FinanceChargePreferences value) {
        this.financeChargePreferences = value;
    }

    /**
     * Gets the value of the jobsAndEstimatesPreferences property.
     *
     * @return
     *     possible object is
     *     {@link JobsAndEstimatesPreferences }
     *
     */
    public JobsAndEstimatesPreferences getJobsAndEstimatesPreferences() {
        return jobsAndEstimatesPreferences;
    }

    /**
     * Sets the value of the jobsAndEstimatesPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link JobsAndEstimatesPreferences }
     *
     */
    public void setJobsAndEstimatesPreferences(JobsAndEstimatesPreferences value) {
        this.jobsAndEstimatesPreferences = value;
    }

    /**
     * Gets the value of the multiCurrencyPreferences property.
     *
     * @return
     *     possible object is
     *     {@link MultiCurrencyPreferences }
     *
     */
    public MultiCurrencyPreferences getMultiCurrencyPreferences() {
        return multiCurrencyPreferences;
    }

    /**
     * Sets the value of the multiCurrencyPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link MultiCurrencyPreferences }
     *
     */
    public void setMultiCurrencyPreferences(MultiCurrencyPreferences value) {
        this.multiCurrencyPreferences = value;
    }

    /**
     * Gets the value of the multiLocationInventoryPreferences property.
     *
     * @return
     *     possible object is
     *     {@link MultiLocationInventoryPreferences }
     *
     */
    public MultiLocationInventoryPreferences getMultiLocationInventoryPreferences() {
        return multiLocationInventoryPreferences;
    }

    /**
     * Sets the value of the multiLocationInventoryPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link MultiLocationInventoryPreferences }
     *
     */
    public void setMultiLocationInventoryPreferences(MultiLocationInventoryPreferences value) {
        this.multiLocationInventoryPreferences = value;
    }

    /**
     * Gets the value of the purchasesAndVendorsPreferences property.
     *
     * @return
     *     possible object is
     *     {@link PurchasesAndVendorsPreferences }
     *
     */
    public PurchasesAndVendorsPreferences getPurchasesAndVendorsPreferences() {
        return purchasesAndVendorsPreferences;
    }

    /**
     * Sets the value of the purchasesAndVendorsPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link PurchasesAndVendorsPreferences }
     *
     */
    public void setPurchasesAndVendorsPreferences(PurchasesAndVendorsPreferences value) {
        this.purchasesAndVendorsPreferences = value;
    }

    /**
     * Gets the value of the reportsPreferences property.
     *
     * @return
     *     possible object is
     *     {@link ReportsPreferences }
     *
     */
    public ReportsPreferences getReportsPreferences() {
        return reportsPreferences;
    }

    /**
     * Sets the value of the reportsPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link ReportsPreferences }
     *
     */
    public void setReportsPreferences(ReportsPreferences value) {
        this.reportsPreferences = value;
    }

    /**
     * Gets the value of the salesAndCustomersPreferences property.
     *
     * @return
     *     possible object is
     *     {@link SalesAndCustomersPreferences }
     *
     */
    public SalesAndCustomersPreferences getSalesAndCustomersPreferences() {
        return salesAndCustomersPreferences;
    }

    /**
     * Sets the value of the salesAndCustomersPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link SalesAndCustomersPreferences }
     *
     */
    public void setSalesAndCustomersPreferences(SalesAndCustomersPreferences value) {
        this.salesAndCustomersPreferences = value;
    }

    /**
     * Gets the value of the salesTaxPreferences property.
     *
     * @return
     *     possible object is
     *     {@link SalesTaxPreferences }
     *
     */
    public SalesTaxPreferences getSalesTaxPreferences() {
        return salesTaxPreferences;
    }

    /**
     * Sets the value of the salesTaxPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link SalesTaxPreferences }
     *
     */
    public void setSalesTaxPreferences(SalesTaxPreferences value) {
        this.salesTaxPreferences = value;
    }

    /**
     * Gets the value of the timeTrackingPreferences property.
     *
     * @return
     *     possible object is
     *     {@link TimeTrackingPreferences }
     *
     */
    public TimeTrackingPreferences getTimeTrackingPreferences() {
        return timeTrackingPreferences;
    }

    /**
     * Sets the value of the timeTrackingPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link TimeTrackingPreferences }
     *
     */
    public void setTimeTrackingPreferences(TimeTrackingPreferences value) {
        this.timeTrackingPreferences = value;
    }

    /**
     * Gets the value of the currentAppAccessRights property.
     *
     * @return
     *     possible object is
     *     {@link CurrentAppAccessRights }
     *
     */
    public CurrentAppAccessRights getCurrentAppAccessRights() {
        return currentAppAccessRights;
    }

    /**
     * Sets the value of the currentAppAccessRights property.
     *
     * @param value
     *     allowed object is
     *     {@link CurrentAppAccessRights }
     *
     */
    public void setCurrentAppAccessRights(CurrentAppAccessRights value) {
        this.currentAppAccessRights = value;
    }

    /**
     * Gets the value of the itemsAndInventoryPreferences property.
     *
     * @return
     *     possible object is
     *     {@link ItemsAndInventoryPreferences }
     *
     */
    public ItemsAndInventoryPreferences getItemsAndInventoryPreferences() {
        return itemsAndInventoryPreferences;
    }

    /**
     * Sets the value of the itemsAndInventoryPreferences property.
     *
     * @param value
     *     allowed object is
     *     {@link ItemsAndInventoryPreferences }
     *
     */
    public void setItemsAndInventoryPreferences(ItemsAndInventoryPreferences value) {
        this.itemsAndInventoryPreferences = value;
    }

}

redpajama_set_name: RedPajamaGithub


What Does "Changing The Way Real Estate Is Done" Mean?
We work as a team. Members work in roles that fit their nature gifts and do not attempt to be experts in every area.
We communicate regularly, honestly and clearly.
Our team makes use of the newest and most advantageous technology available.
David Upchurch Real Estate is made up of true market experts. A REALTOR pin is neat, but daily commitment to excellence is what is needed in the tricky world of real estate transactions.
I firmly believe that a home buyer or seller ought to be able to trust his or her real estate advisor on the same level as his CPA, Attorney or Family Doctor. If it isn't my team, find another team, but never settle for anything less than a true professional with proven expertise to guide you through such a significant decision.


Group Exhibition Of Paintings is an event that took place between 18-Oct-2006 and 05-Nov-2006 in Hyderabad.
Be the first to comment on Group Exhibition Of Paintings! Just use the simple form below.
fullhyd.com has 700,000+ monthly visits. Tell Hyderabad what you feel about Group Exhibition Of Paintings!


text:
Billionaires vs. the people in Connecticuts tax the rich fight
August 1, 2009	7:37 AM CST
HARTFORD, Conn. — Four limos filled with "billionaires" drove up to the steps of the Connecticut State Capitol yesterday to hold a "Thank you Governor Rell for NOT taxing the rich!" rally.
The July 30 tongue-in-cheek street theater event, called "Billionaires for Budget Cuts," was sponsored by the Working Families Party of Connecticut.
Connecticut is one of a handful of states that has not yet adopted a state budget. The Democratic-controlled state Legislature is at loggerheads with Gov. Jodi Rell, a Republican.
Connecticut is one of the richest states in the United States, and the Democrats are pushing for a fair tax structure to help pay for an $8.5 billion shortfall in the state's budget. As part of an effort to close that gap the Democrats are proposing a progressive income tax that would increase taxes on the rich. Currently the richest 1% of Connecticut residents pays only 4.7 % of their income in state taxes while lowest paid workers pay 10.9%. Gov. Rell has refused to discuss a progressive income tax with the Democrats and the budget fight is heating up.
"Taxes are for little people," sang out the "billionaires" clad in tuxedos and top hats, or ball gowns, at the rally here. The "billionaires" carried signs that read, "Stop education funding wow," "Gov. Rell — our best investment ever," and "Don't tax the rich." A banner trailing from a small plane that flew over the Capitol said, "Cheers to Rell."
The response of Gov. Rell and the Republican State Committee, who have provided no answers to the proposed progressive income tax, reverted to an old McCarthy anti-communist tactic. Rell's office put out a press release saying that the Democrats "have apparently aligned themselves with the Connecticut Communist Party for their latest act of political theater." They were referring to the party's blog posting that announced the "Billionaires for Budget Cuts" event. The blog address is . Meanwhile, the fight for a fair budget continues.
Daily Online
Senate Republicans, after stormy debate, sink voting rights bill
Indictment of Oath Keeper Rhodes on seditious conspiracy leads to Trump...


text:
Q: WiX: Manually set the cost of a feature I have a non-standard feature in my installer, which doesn't contain any installable files, but triggers a custom action instead. As this feature doesn't contain any official file components, the installer displays 0 as the required disk space for this feature.
How can I set the cost of a feature manually in WiX?

A: You can use the ReserveCost element to associate additional cost with one of your Component elements. You will need to have at least one Component in the install to associate with Feature.


Man with van southall ltd.
I want to sell my mobile phone quick!!! all standart accsories and box phone is only one month old.
...g as original. have added a phone cover to help you keep it clean. cash on pickup. location: oxford road, manchester uni.


Microsoft are really outdoing themselves at the moment as it seems that they have released another pair of updates for Windows 7 machines that reboots the computer when connecting to a wireless or VPN connection.
We have had around 40 machines with these two updates that have seen this problem. We have had to remove these from circlation on our corporate network and for external users, we have had to manually remove them and clear out the SoftwareDistribution folder to stop them reinstalling.
A few symptoms they have mentioned, but nothing about wireless or VPN connections being affected – but we have had this problem.
There is an issue with Windows and third-party software that is related to a missing file (oem<number>.inf). Because of this issue, after you apply this update, the network interface controller will stop working.
Nothing from Microsoft on this one yet, but we have seen problems with it.
So, if you are still experiencing any weird issues with your machines, take a stab at removing these and see if it helps.
If you need some guidance on what to do to remove these or any other updates, be it on a single machine or mass corporation remove, take a look at this post as we have added some instructions towards the end of the post that you may find helpful.
We would love to hear from you if you to are having any issues with these, or indeed any other, Microsoft Updates. Just leave us a message below in our comments section and we will pick them up shortly after you post.


Ballon Rouge proudly presents its third exhibition, Samuel Jablon's Doomed, curated by Brigitte Mulholland. This is the artist's first show with Ballon Rouge, and his second solo exhibition in Los Angeles.
Doomed is a presentation of new paintings by Samuel Jablon, who paints words and letters as objects broken apart. His work is an amalgam of poetry and painting, where thick letters sprawl across colorful surfaces, forming apocalyptic words and phrases. Jablon's work mirrors the poetic confusion we carry inside as we struggle to describe the significance of a world reduced to an image on a screen, or the helplessness we feel when reading yet another awful headline.
At a time when language and words are increasingly drifting from meaning, Jablon reminds us that words are embodied realities of human experience, used to connect and share with other human beings. In one painting, splashy pink and yellow hues meld into darker browns and blacks, announcing The damage is done don't get stained. In another, a purple background, thickly built up and drizzled with white, is covered with a surprisingly bright and cheerful orange that boldly proclaims Doomed. Pushing against the numbness with which we trust reports of conflicts that we can only read about, Jablon's paintings recreate and embody the terror and optimism specific to being alive right now.


text:
Friday, jul 19 72°
Missing 25-Year-Old From Westchester Located
Joe Lombardi
Facebook @joe_lombardi Email me Read More Stories
Kyle V. Jabusch Photo Credit: New York State Police
The 25-year-old who went missing from his home in home in Northern Westchester last week has been located and is safe, state police said.
Kyle V. Jabusch had last been seen at his Northern Westchester residence on Park Avenue in Goldens Bridge at approximately 7 a.m. on Wednesday, Dec. 5.
"Kyle was located safely with the assistance of Westchester County Police," state police announced on Sunday.
Original report:
An endangered 25-year-old has gone missing and his family and state police are asking the public's help in locating him.
Kyle V. Jabusch was last seen at his Northern Westchester residence on Park Avenue in Goldens Bridge at approximately 7 a.m. on Wednesday, Dec. 5.
He left in a black 2013 Hyundai Elantra with NY registration HYT3172. He is possibly traveling westbound through Pennsylvania based on recent credit card transactions. Kyle has blond hair, blue eyes, is 6-feet tall and weighs approximately 160 pounds.
Any person that may have information on the whereabouts of Kyle Jabusch is asked to contact the New York State Police at 914-769-2600.
Share this story on Facebook by clicking on the Facebook icon below.
Follow Joe Lombardi on Facebook and Twitter


Today four participants from the Marshall Islands joined us – George, Junior, Hertes and Vercina. Although we are all still waiting for the Kazakh participants before beginning the real work, we started today with introductions to learn a little about each, their community and their Hibakusha story. Journalists from the Japanese press interviewed participants, photographed and filmed for media such as Hiroshima TV and the Asahi Shimbun.
After some background information from Bo and Mick about global nuclear testing and bombing and an overview of the aims of the workshop itself, we made an initial foray into interviewing and recording. The students came up with messages to send to the Marshallese community who have settled in Arkansas, to send out greetings and support on March 1st, the anniversary of the Bravo test, Nuclear Victims Remembrance Day.
The most joyful part of the day though, was piling into two taxis to the airport to collect the Kazakh participants who had finally been able to enter the Marshall Islands.


Various different photosensitizers were compared to Photofrin® II with respect to their potential for causing direct tumor cell inactivation and/or vascular damage. GaCl-phthalocyanine of mixed sulfonation, while being 10 x more efficient than Photofrin® II in tumor cell inactivation, caused equal vascular photosensitization. Monosulfonated AlC1-phthalocyanine, on the other hand, was sparing to the vasculature, while still exhibiting good tumor cell effects. Large differences in vascular photosensitization were also observed with tetra- and monosulfonated tetraphenylporphines.
Tumor destruction in photodynamic therapy is the result of the combination of direct cellular toxicity and damage to tumor microvasculature. These phenomena appear to be caused by tissue interactions with toxic oxygen compounds which are formed when light interacts with photosensitizing agents. Although injury to cell membranes, mitochondria and the nucleus have been noted, such injuries by themselves tend to be sublethal and cannot totally account for the effectiveness of PDT. The mechanism of effect of PDT on the vasculature has not been fully investigated. The vascular effects are believed to involve both intravascular and perivascular phenomena. Platelet aggregation appears to be an early event. Changes to the endothelium, and smooth muscle contraction as well as increased capillary permeability have also been observed during therapy. Initial experiments using'cyclooxygenase inhibitors indicate that arachidonic acid metabolites are active elements in producing the vascular phase of the therapeutic response and that these microvasculature effects appear to be critical to permanent tumor destruction.
The effects of porphyrins and radiation on inflammation include activation of the complement system, generation eicosanoids from mast cells, macrophages, and endothelial cells, alteration in cutaneaous eicosanoid metabolism, activation of factor XII-dependent pathways, release of mediators from mast cells, and dermal accumulation of neutrophils. These effects contribute to the development of porphyrin-induced cutaneous inflammation, which can be seen in patients with porphyrias and as a consequence of photodynamic therapy.
Blood Flow Changes In Transplantable Urothelial Tumors Treated With The Metallopurpurin, SnET2 And Light.
Changes in blood flow to transplantable bladder tumors growing in Fischer rats were measured after photodynamic therapy with the photosensitizer tin (II) etiopurpurin dichloride (SnET2) using the radioactive microsphere technique. As with the other photosensitizers, hematoporphyrin derivative and chloroaluminum tetrasulfophthalocyanine, SnET2 and light caused a rapid decrease in tumor blood flow. This occurred when the vehicle for photosensitizer delivery was either an emulsion or a liposome. Systemic heparinization of animals did not alter changes in tumor blood flow.
We have been investigating the dose dependent modification of p02, pH, and phosphate metabolism within tumors subjected to PDT. The system employed in all studies has been the C3H mouse mammary adenocarcinoma tumor model. All tumors were treated at a size of 7.0 ± 0.5 mm (maximum diameter) with biologically defined "doses" ranging from the TCD10 to the TCD90 response level (i.e. from 200 J/cm2 to 600 J/cm2 in this system). The dose of Photofrin II employed in all studies was 12.5 mg/kg (IV) with light treatment 24 hours later (drug kindly supplied by QLT Inc.). All light treatments were at 632 nm (Coherent). Both microelectrodes and 31P NMR spectroscopy (Varian VXR 400) were employed to measure the intralesional values. Results indicate a "dose" dependent reduction in intracellular ATP occurring within 4 hours post treatment. At the TCD90 level, no detectible high energy phosphates are seen within 4 hours following treatment. A similar trend is observed when intralesional p02 is measured with significant decreases seen within 4 hours post treatment. Microelectrode measurements of pH (predominantly extracellular) showed no significant change for up to 72 hours post treatment, independent of "dose". However, some "dose" dependent changes in pH gradient [pH (intracellular) - pH (extracellular)] have been observed.
Porphyrin photodynamic therapy directed specifically to the hind leg of various strains of mice was found to induce a high percentage of lethality at dosages which would be required to achieve cures in tumor bearing mice. Toxicity was observed in both pigmented and albino mouse strains. An inverse relationship between light dose rate and lethality was documented. Anti-coagulant drugs and anti-inflammatory agents which inhibit cyclo-oxygenase had protective effects. The response induced by localized PDT appears to mimic that of a classical traumatic shock syndrome and may be limited to PDT in small animals such as mice.
One of the side effects of peritoneal photodynamic treatment (PDT) of mice is a systemic suppression of contact hypersensitivity (CH) responses. Treatment with either laser alone or the photosensitizer, Photofrin II (PFII), alone does not cause suppression of CH responses. Immunosuppression of CH responses is an active process that is adoptively transferable using viable cells, but not serum, from PDT-treated mice. The induction of adoptively transferable suppressor cells in PDT-treated mice requires exposure to an antigenic stimulus, yet the suppressor cells are antigen non-specific in their function. T cell function in PDT-treated mice, as measured by the ability of splenic lymphoid cells to generate allogeneic cytotoxic T lymphocyte responses, is comparable to that detected in normal mice. However, the ability of spleen cells from PDT-treated mice to act as stimulators in a mixed lymhocyte reaction is dramatically impaired, suggesting that the major cell type affected by peritoneal PDT is of the macrophage lineage. Support for this concept is provided by experiments in which spleen cells from PDT-treated mice were chromatographically separated into populations of T cells, B cells and macrophages prior to adoptive transfer into naive recipients. The results indicate that the cell type mediating adoptively transferable suppression of CH responsiveness is of the macrophage lineage. Analysis of hematologic parameters revealed that induction of suppression by PDT-treatment was associated with a marked neutrophilia and lymphocytosis, and was also accompanied by a 5-fold increase in concentration of the acute phase protein, Serum Amyloid P. Finally, attempts to ameliorate PDT-induced immunosuppression by pharmacologic intervention have proved successful using implants of pellets that release indomethacin at a rate of 1.25µg/day. Thus, the data suggest that PDT-treatment induces macrophages to produce factors (e.g., prostaglandins) that are known to be potently immunosuppressive.
This study was undertaken to determine if photodynamic therapy (PDT) produces an immunologic response in patients treated for bladder cancer. Gamma interferon, interleukin 1-beta, interleukin 2 and tumor necrosis factor-alpha were assayed in the urine of four patients treated with photodynamic therapy for bladder cancer, in seven patients undergoing transurethral procedures, and in five healthy control subjects. Quantifiable concentrations of all cytokines, except gamma interferon, were measured in urine samples from the PDT patients treated with the highest light energies, while no urinary cytokines were found in the PDT patient who received the lowest light energy or in the control subjects. These findings suggest that a local immunologic response may occur following PDT for bladder cancer. Such an immunologic response activated by PDT may be an additional mechanism involved in bladder tumor destruction.
Monoclonal antibodies with reactivity to T suppressor cells and T suppressor factors, conjugated to hematoporphyrin, when injected intravenously into mice bearing either the P815 mastocytoma or L1210 thymoma were able to reject a significant number of palpable tumors, in comparison to appropriate controls. This effect is attributed to immune modulation by selective elimination of T suppressor cells. Investigation of novel methodology for reliable linkage of photosensitizers to antibodies indicate that derivatives of polyvinyl alcohol provide suitable carriers for photosensitizers. Such carriers can relatively easily be conjugated to monoclonal antibodies without jeopardizing the biological activity of the antibody or the photosensitizer, or the solubility of the complex.
A number of laboratories have demonstrated that immunoconjugates may have potential in phototherapy of cancer. The phototoxic effectiveness of these conjugates may be increased by manipulation of irradiation parameters and by biochemical and immunologic modulation. Results from experiments aimed at potentiation of immunoconjugate photosensitization are presented.
Determination of the dependence of Photofrin II concentration on the time integrated space irradiance in tissue allows the definition of Photodynamic dose to be formulated as an integral of sensitizer concentration over the time integrated space irradiance at each point in tissue. This integral, together with a measurement of the depth of necrosis produced by the clinically measurable sensitizer and light doses, and the tissue optical properties allows the calculation of the expected necrotic depth for any similar tissue. These predictive calculations are carried out for various dosimetric conditions and a variety of clinically interesting sources e.g. long cylinders or spherically symmetric sources imbedded in the tissue, uniform surface illumination over a wide field or a spherical source at the center of a water filled bladder. The results are presented in graphical form and are based on published clinical data.
Simple Theory, Measurements, And Rules Of Thumb For Dosimetry During Photodynamic Therapy.
Dosimetry of laser fluence rates within a tissue are required for proper planning of photodynamic therapy at a specific site on a given individual. A simple one-dimensional theory of light penetration into tissue is presented. A device for measurement of the total reflectance and the lateral diffusion of light provides a simple means for specifying the tissue optical parameters that govern laser dosimetry. Rules of thumb for complicating factors such as narrow laser beams and optical fiber delivery are discussed.
In Vivo Light Dosimetry For Interstitial Photodynamic Therapy: Results Of Clinical Importance.
Effective treatment of non-superficial tumors using HpD-PDT requires the development of interstitial light application. In order to determine the efficacy of interstitial HpD-PDT, a dose effect relationship has been established in a rat rhabdomyosarcoma. Because of the lack of data about the light distribution in tissue a miniature isotropic light detector was used throughout this study for in vitro and in vivo light dosimetry, permitting evaluation of tumor response versus "light dose" (i.e. light energy fluence) distribution. Effects of increased light absorption due to the photosensitizer concentration in the tumor tissue were observed and taken into account in reporting the light dose throughout the tumor volumes. Light dosimetry during HpD-PDT treatments was performed as a check on the prescribed calculated light dose levels. Measurements demonstrate a gradual but drastic decrease in light penetration, beginning almost immediately after the start of the treatment. This phenomenon, which is also observed in clinical HpD-PDT treatments, complicated the assessment of the required light energy fluence for tumor control. The dose-effect experiments show that a high tumor control rate is achievable in a single HpD-FDT treatment. Failures were strongly correlated with inadequate light dose or light dose distribution. Successful treatment appeared to be highly dependent on the light dose at the tumor periphery. Vascular damage in a small margin of the surrounding normal tissue seems to be required. This implies that tumor treatment selectivity is mainly determined by restricted light penetration in tissues irradiated by local light application.
When light is diffusely reflected from tissue containing a dye, such as a photosensitizer, with a known absorption spectrum, the changes in the reflectance spectrum caused by the presence of the dye can be identified and correlated with the dye concentration. A feasibility study' of this method for the noninvasive determination of the concentration of photosensitizers in tissue found, however, that the changes in reflectance also depended on the optical properties of the tissue. In this study we propose a simple model of light propagation which allows quantitative prediction of the sensitivity of the method. The optical absorption and scattering coefficients required as input for the model are obtained from two ancillary noninvasive measurements: the total diffuse reflectance and the spatial variation of the local diffuse reflectance. Experiments performed using tissue-simulating phantoms suggest that the simple model, when combined with the ancillary measurements, allows absolute calibration of the method to within 20%.
Photochemical reactions are used in photodynamic therapy of cancer and other disease. The cytotoxic agent in photochemotherapy is usually singlet oxygen. Thus measurements of singlet oxygen production or concentration may allow prediction of the biological response. The decrease in fluorescence of L-tryptophan because of reaction with singlet oxygen, the decrease in absorbance of a dye such as RNO subject to secondary oxidation by singlet oxygen, and the decrease in fluorescence of the most common photosensitizer, dihematoporphyrin ether/ester (DHE) because of photobleaching, have been investigated in solutions in vitro. The most promising method for dosimetry and prediction of biological response appears to be the photobleaching of DHE.
Methods for the pre-clinical evaluation of new photosensitizing dyes are described. The resulting information can provide useful leads concerning likely modes and sites of localization. But correlations between results obtained in cell culture and in animal tumor models are sufficiently weak to indicate the need for caution in extrapolation of any in vitro result.
Sulfonated metallo phthalocyanines (M-SPC) are extensively studied as sensitizers for photodynamic therapy of cancer. They strongly absorb clinically useful red light with absorption maxima between 670-680 nm. Their photodynamic properties depend on the nature of the central metal ion as well as the degree of substitution on the macrocycle. The zinc, aluminum and gallium complexes are efficient photo-generators of singlet oxygen, the species most likely responsible for their phototoxicity and tumoricidal action. Tissue distribution pattern, cell penetration and dye aggregation are strongly affected by the degree of sulfonation of the dyes. Mono- and disulfonated M-SPC have the highest tendency to form photo-inactive aggregates. However, these lower sulfonated dyes more readily cross cell membranes resulting, in vitro, in enhanced phototoxicity. In vivo, the highly sulfonated hydrophilic M-SPC show the best tumor localization properties but the lower sulfonated dyes still exhibit the best photo-activity. Variations in activities between the differently sulfonated M-SPC are far less pronounced in vivo as compared to in vitro conditions. Such discrepancies are explained by the combined action of numerous vectors including interaction of M-SPC with plasma proteins, vascular versus cellular photo-damage, tumor retention, cell penetration as well as the degree of aggregation of the dye.
A series of benzochlorins have been prepared and tested for tumoricidal activity using the FANFT-induced rat bladder tumor model. Results indicate that these chlorin derivatives, in combination with red light, can cause significant tumor regression at doses as low as 0.5 - 1.0 mg/kg body weight. This compares favorably with other sensitizers tested in the same model and suggests that further studies on the effectiveness of benzochlorins in photodynamic therapy be performed.
Spectrofluorometric and FACS (Fluorescence Activated Cell Sorting) analyses were employed to determine 1) the maximal fluorescence excitation and emission peaks characteristic of BPD, benzoporphyrin derivative, 2) which structural analogue of BPD, BPD-monoacid ring A (BPD-MA), BPD-monoacid ring B (BPD-MB), BPD-diacid ring A (BPD-DA) or BPD-diacid ring B (BPD-DB) fluoresced to the greatest extent in the presence of leukemic cells and 3) to determine whether substantive differences existed in the uptake of BPD by human or murine leukemic versus normal human or murine mononuclear cells. Spectrofluorometric analysis revealed that the maximal fluorescence excitation peak of BPD (BPD-diacid ring A) was situated at 420 nm with a less prominent peak at 356 nm. Fluorescence emission scans, in which 420 nm was used as the excitation wavelength, revealed a single prominent fluorescence peak at 690 nm. FACS analysis revealed that negligible differences in fluorescence existed between leukemic cells incubated with BPD-MA, BPD-MB, BPD-DA, or BPD-DB upon excitation with visible light (488nm). However, subsequent to uv excitation cells incubated with BPD-MA fluoresced to the greatest extent followed by BPD-MB, BPD-DA, and BPD-DB respectively. Pronounced differences in red fluorescence were consistently observed between leukemic cells (HL60, K562, and L1210) and normal human or murine bone marrow cells incubated with BPD-MA. These observed differences in BPD-mediated fluorescence provide the rationale for sorting leukemic from normal cells via FACS and may constitute a novel method for extra-corporeal purging of remission marrow in autologous bone marrow transplantation.
The biological activity of a series of porphyrin dimers and trimers with ester and ether linkages, related to Photofrin II and some new photosensitizers with better optical properties are discussed. The structure and biological activity of a large number of photosensitizers, recently reported in the literature, are also reviewed.
The cellular characteristics of three photodynamic sensitizers are described. The mechanism of uptake by cultured cells was determined for Photofrin II, Mono L-aspartyl Chlorin e6, and Chloroaluminum Sulfonated Phthalocyanine. In addition, the subcellular localization, sensitizer photostability and photochemistry were studied. Also, the integral relationship between the biological characteristics and the photochemistry of the sensitizers is discussed. Photofrin II enters the cells through passive diffusion across the plasma membrane and primarily localizes in the mitochondria. Both the chlorin and phthalocyanine are transported into the cell through constitutive pinocytosis and thus localize in the lysosomes.
Chloroaluminum sulfonated phthalocyanine (A1PCS) was administered intravenously to clinically normal dogs, and A1PCS levels were determined in tissues using a sensitive assay. A1PCS accumulated to high levels in liver, spleen, bone marrow, kidney, and lung. These tissue levels confirm previous determinations in mice and rats. Only a small amount of dye was retained in skin and very small amounts in muscle and brain. A1PCS was cleared from the blood within 24 h, and excreted primarily by urine. Serum clearance was faster in males than in females. There were also significant tissue distribution differences between the genders, particularly during the first 12 h. The low levels of A1PCS in skin suggest that cutaneous photosensitivity and toxic skin reactions using this photosensitizer in photodynamic therapy of cancer may be eliminated. The difference in tissue distribution between genders is not only intriguing, but indicates that the optimal time window for treatment of various tissue sites may vary by gender.
A Clark-type microelectrode is used to measure oxygen consumption rates in laser-irradiated solutions of photosensitizer and photosensitizer-containing cells. The presence of a singlet oxygen-specific acceptor molecule, furfuryl alcohol, permits indirect determination of relative singlet oxygen generation efficiencies from oxygen consumption data. Solution and cell measurements are performed which compare photosensitizing efficiency of Photofrin-II (PII), tetraphenylporphine tetrasulfonate (TPPS4), mono-L-aspartyl chlorin e6 (MACE), and chloroaluminum sulfonated phthalocyanine (CASPc). Relative singlet oxygen generating efficiency, per-unit-weight and per-absorbed-photon, were determined to be: MACE > CASPc > TPPS4 > PII and TPPS4 > MACE > PII > CASPc, respectively. When these results are compared to oxygen consumption in photosensitizer-containing cells, differences in the order and magnitude of photosensitizing efficiencies are observed. The relative oxygen consumption rate in cells was: PII CASPc > MACE TPPS4. Additional information concerning cell killing efficiency is derived from clongenicity assays. These data indicate that consideration of singlet oxygen generating ability in solution must be considered in conjuntion with cellular assays in order to provide an in vitro estimate of photosensitizer efficacy.
Intracellular Distribution Of Porphyrin-Based Photosensitizers In In Vitro Cultured Human Bladder Tumor Cells.
The Increasing use of porphyrin-based compounds for photodynamic therapy raises concerns about the intracellular distribution of these substances in target cells. We are utilizing chlorophyll derivatives as photosensitizers and exploring their intracellular distribution in in vitro cultivated EJ human bladder tumor cells. The cells are exposed to these compounds delivered within a liposome-based carrier system as well as in the free form. High resolution subcellular fractionation approaches are employed to examine the cellular localization of the photodynamic agents. Free pheophorbide a and hematoporphyrin derivative localize, almost exclusively within the plasma membrane of cells exposed to the agents for 90 min. In contrast the pheophorbide a loaded liposomes are readily taken into lysosomes, presumably by endocytosis, if presented to the cells at 4° and then incubated with the cells at 37°. However cells exposed to the liposomes continuously at 37° accumulate the pheophorbide a in the plasma membrane. These studies indicate that untargeted liposomes exhibiting a decreased fusegenic tendency than employed in these studies may allow for an effective delivery of photodynamic agent to lysosomes.


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right-arrow We Sound Human Blog
Artist Spotlight: Onyx Lane
Onyx Lane is a boutique full-service music production and artistic planning company with a focus on composing, recording, producing, and mixing music for film scores and classical ensembles. They are based in Oklahoma City, OK but travel all over the world when recording on location.
Founded by Christina Giacona and Patrick Conlon, Onyx Lane has extensive credits and provides services for projects in a variety of mediums including album recordings, film, television, installations, and live performances.
"We're really fortunate to get to work with so many incredible artists and be a part of their musical journeys... Wouldn't have it any other way!"
What types of projects are you currently working on?
This next month is a little crazy in the best possible way, but also a pretty good picture into the musical code-switching that we do on a regular basis.
Right now we're working on doing the dance compositions, orchestrations, and arrangements for a new musical that will be premiering in March in Farmington, New Mexico based on a sort of fantastical imagining of what might have happened at MGM in-between Gene Kelly starring in The Three Musketeers and shooting Singin' in the Rain. Really cool switches between golden era Hollywood fight scenes (major Korngold vibes) and jazzy, Singin' in the Rain / Summerstock tap, dance, and ballad numbers.
Tomorrow, we'll be producing and engineering a session we contracted for our friend Brian Byrne at his composing and recording studio in Purcell, Oklahoma.
Later in the week, we're recording, producing, and score mixing an orchestra and choir track for a feature film with the awesome people at Green Pastures Studios.
Then, two weeks from now, we're working with the Oklahoma City Philharmonic and recording/producing a classical violin concerto for an album for composer Jonathan Leshnoff featuring the Berlin Philharmonic's concertmaster Noah Bendix-Balgley.
Three weeks out, we're in the composing hole for a commission called Solid, Liquid, Gas that'll be premiered in April by the Oklahoma Virtuosi Chamber Orchestra, and then at the end of March we're in Canada performing and teaching masterclasses for a music festival at Brandon University put together by my fellow Canadian Dr. Catherine Wood.
We're really fortunate to get to work with so many incredible artists and be a part of their musical journeys. Wouldn't have it any other way!
Why did you choose the Gypsy Cafe Sample Library?
We Sound Human really came up clutch for us with the Gypsy Cafe library. We were working on a really sweet short film with a family-friendly Western vibe. Most of the cues were in the action/comedy/western world that sample libraries with some live overdubbing do really well, but there was one temp reference track towards the end that was a straight-up hot jazz, Quintette du Hot Club de France - Stéphane Grappelli / Django Reinhardt style cue.
One of my first three cassettes that I stole into my room when I was 3 or 4 was actually a best of Quintette du Hot Club de France compilation, so I've grown up obsessed with that style and absolutely love it.
The issue is that for this film there really wasn't the budget or the time to write out an original chart, hire a five-piece, record it, mix it, and then submit it to the director especially since this would be an underdub (meaning we're doing a live recording without final cue approval). BUT we still wanted that sound, and we were determined to do it one way or another.
Finding the Gypsy Cafe library from We Sound Human ended up being the perfect match, since what we were able to do was basically remix the song structure, mute a bunch of the solo guitar licks, and add in a live jazz fiddle part.
Once we had the chart down, Christina recorded me improvising, and then we went back in and moved things around a little more so the fiddle became the primary voice, then tracked the fiddle licks and solos through our Grace and Millennia preamps.
Finally, to get everything to sound like it belonged together, we gave everything a more vintage feel through a bunch of plugins, put everything in a room together with some Liquidsonics Cinematic Rooms reverb, and mixed and mastered it through an analog signal chain utilizing an 1176LN, two LA-2As, a Shadowhills Dual Vandergraph Compressor, Manley Massive Passive EQ, and Neve Portico II master buss processor.
What you'll hear in the tutorial video are the unmastered track stems.
"So what would have been a 3-4 day affair (writing out charts, contracting, recording in a studio, auditioning and editing, mixing, and mastering) became a half day project AND we had the flexibility to easily revise it to match the final cut of the film."
If you'd like to find out more about Onyx Lane, and I absolutely suggest you do, then check them out on their Facebook Page or Website.
Explore the sounds of Gypsy Cafe!
Travel back to the old country where the soft glow of flickering candlelight lit your way to the band of gypsies serenading the moon at the gypsy cafe. Enjoy this vast collection of old time romanticism in the modern age.
Traditional sounds of the mandolin, gypsy jazz guitar, accordion, wine glasses together with modern instruments like electric guitar, bass and drums gives you that old world vibe your tracks crave. The entire library is hand-crafted and has been painstakingly woven together from a mixture of Gipsy Jazz, Parisian, and Italian music to create the perfect combination of old meets new.
Explore your bohemian side and discover the hidden world of the gypsies.
Includes: 5.2 GB (9 kits) gypsy jazz music samples.
Styles: Gypsy Jazz, Parisian, and Italian sounds.
Instruments: Mandolin, accordion, guitar & more.
Drums: Grooves, multitrack, loops & one-shots.
Sounds like: Moody and upbeat swing rhythms.
Crafted for: Composers, producers, musicians.
Formats: All music DAWs, loop & editing software.
Explore the sounds of Gypsy Cafe


Welcome to another episode of the Dollar Bin. This week, to rev up for Halloween and Comicsfest, Adam, Shawn, and special guest Josh, discuss some of their favorite horror, scary, spooky comics that they are reading. Did someone say Comicsfest? We will be at Richard's Comics and Collectables helping out, along with many guest artists, including Dollar Bin participants, J Chris Campbell, Duane Ballenger, Wes, Brooks, and Joey Weiser.


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A Matter of Balance
Walk with Ease
Senior Meals Drive-Thru
Five free meals per week
Saturday, May 23 and
9 a.m. until 10:30 a.m.
Bethune Recreation Department
109 College St. Bethune, SC 29009
11:30 a.m. - 1 p.m.
Across the street from the Piggly Wiggly
51 East DeKalb St. Camden, SC 29020
1:30 p.m. - 3 p.m.
Elgin Town Hall
2469 Main St. Elgin, SC 29045
First come, first serve until the meals run out.
Requirements to receive these services:
Must be age 60 or older OR must be taking a meal to a person age 60 or older
Must be a resident of Kershaw County, SC
Must provide name, address, and phone number of persons receiving meals at pick-up
Each individual must show a state ID
A maximum of two sets of five meals allowed per car
Cannot be a recipient of other Meals on Wheels
These meals are sponsored by a grant from the Blue Cross & Blue Shield Foundation.
906 Lyttleton St
bruce@kershawcoa.org
Kershaw County Council on Aging © 2021 All Rights Reserved | Site developed and maintained by Broadstreet.net


How much gas will you use on your road trip?
Will the cost of gas bleed your travel budget dry?
Americans love road trips. In 2011, AAA estimated that 32.8 million Americans drove a distance of 50 miles (80.5 kilometers) or greater during the Fourth of July weekend [source: AAA]. While that's an impressive figure, it's nearly a million less than the number of travelers that hit the road in 2010. Why? The price of gasoline. The national average for a gallon of regular unleaded jumped nearly a dollar a gallon from the previous year, from about $2.70 to $3.60 [source: AAA]. The high cost of fuel doesn't have to stall your plans, though. It's easy to minimize the amount of gasoline you'll use on your trip and calculate about how much it will cost you, ensuring your drive is both affordable and carefree.
There are several steps you can take to reduce your gasoline before you even pull out of the driveway. When planning a long road trip, it's a good idea to have a mechanic change the oil and fix any problems that may exist. Repairing a car that's out of tune can improve fuel efficiency by an average of 4 percent, while fixing a faulty oxygen sensor can increase gas mileage by a whopping 40 percent. You should also check to ensure that your tires are properly inflated. For each pound per square inch that your tires are underinflated, your fuel economy is reduced by 0.3 percent [source: EPA]. Finally, pack light. Every 100 pounds added to a car's weight results in a 2 percent reduction in gas mileage, and tying luggage to the top can lead to a decrease of up to 21 percent [source: EPA, Valdes-Dapena].
Once you're on the road, there are more ways to reduce how much gas goes in the tank. Consider taking scenic back roads with lower speed limits; fuel efficiency is dramatically reduced at speeds greater than 60 miles per hour (96.5 kilometers per hour) [source: EPA]. On flatter stretches of road, use the cruise control. Allowing the car to decide when to apply acceleration instead of doing it yourself can increase gas mileage by 10 to 15 percent [source: Valdes-Dapena]. Timing your route properly can also save fuel. Stay away from big cities during rush hour when stop-and-go traffic can bring your progress to a standstill and reduce your gas tank to vapors. Consider investing in a GPS unit or mobile phone app like Google Maps, which can actually display traffic congestion in real time, allowing you to plan a detour far in advance of any problems.
While these tips can reduce your gasoline usage, they won't completely eliminate it, so it's still nice to know about how much fuel you will use on your road trip. Read on to learn how to calculate what your drive will cost.


Neighbors nearby or distant friends.
Resources at hand or opportunities in the future.
Faith in God or connection with princes.
Love in His presence or fantasy over the sky.
but your choices reflect the conditions of your heart!
Previous postSome thoughts on fat you may not know about…A Big Surprise!
Next postYou will renew, run,… and soar!!


Looking to bolster development of new technologies for construction and give industry players a place to test new products, Oracle has created a Construction and Engineering Innovation Lab.
Keeping an eye on weather conditions around critical infrastructure is a persistent problem for public agencies and private owners, particularly in underserved communities far from government weather stations.
In today's energy market, consumers are becoming producers, and technology is placing more control in the hands of the many.
The Industry Leaders Council of the American Society of Civil Engineers is evaluating submissions to a new contest that is soliciting ideas for transforming the future of infrastructure.


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New Schools in Fort Mill, SC
by jackie | Apr 2, 2019 | Schools, Schools
Indian Land Middle School, part of Lancaster County Public Schools
There is so much school news in the growing Fort Mill, SC area!
Development on Catawba Ridge High School in Fort Mill continues and is still scheduled to open in August 2019.
Construction on the new Indian Land High School also progresses, with that school opening in 2020. Once the new school opens, the location of lower schools will shift, with some middle school grades occupying the old high school.
Two new elementary schools are in the development phase, and are also scheduled to open for the 2020–2021 school year. Kingstown Elementary School, located on Mason's Bend Road, and River Trail Elementary School, located near Catawba Ridge High School on the Fort Mill Southern Bypass, have both recently appointment principals and named mascots. For more information, see the school news section on the Fort Mill School District web site.
Forest Creek Middle School is located on Whites Road adjacent to the Catawba Ridge High School site and is scheduled to open for the 2021-2022 school year. The school board recently selected the coyote as this school's mascot.
Questions about where your child will go to school next fall? See the districts' attendance maps (including this Fort Mill school district high school attendance map), or give me a call for help!


Eau Claire (WQOW) – In an effort to contribute to the excitement of downtown's redevelopment, Xcel Energy wants to donate solar-powered charging stations to the city.
Next Tuesday, the city council will decide if they want to accept the donation. According to the agenda, the stations for electronic devices, like cell phones, will be installed in, and near, downtown. If accepted, the city would be in charge of installing and maintaining the stations.
A representative from Xcel Energy told News 18 they've offered the city four poles and it's up to them how many they accept. They place the total value of the four stations around $10,000.
"We are excited to provide this donation of renewable, solar-powered, charging stations for Haymarket Landing. We work closely with our communities and non-profit organizations throughout the region to make a positive impact, and this donation complements the wonderful work that is taking place within downtown Eau Claire and Confluence Project," a representative of Xcel Energy said.


An exciting opportunity has arisen for a candidate of exceptional ability to join our team as Teacher of Business Studies in this over-subscribed and successful high school.
The school has an existing reputation for high quality education with a relentless focus upon high expectations and aspirations.
Please e-mail bechellil@sgsce.co.uk or download an application form and job description below.