Methyl Sulfonyl Methane (MSM) is the biologically active form in which sulfur appears in each one of your cells, all of nature and all living organisms. Pure organic MSM the fourth most important nutrient in the human body, without the proper amount of MSM in our system we cannot produce healthy cells.
MSM is as safe as drinking water but has powerful detoxification capabilities, so make sure to start slowly! Noticeable benefits include soft, supple skin, hair and nails. More flexibility with larger range of movement from the relief of stiff joints and joint pain. Improved digestion, assimilation and energy as tissues become more permeable allowing nutrient uptake. Brighter, clear eyes and the list goes on!
Note: Do not confuse organic mineral sulfur (MSM) with sulpha-based drugs, sulfites, or sulfates. Sulpha-based drugs (sulphonamide) are a group of large compounds known to cause allergic reactions. These are drugs composed of many elements creating large chain molecules which are used as antibiotics. Sulfites are preservatives, antioxidants and browning agents used in foods. Ingestion of these is associated with adverse reactions such as asthma attacks, nausea, and diarrhoea. It is highly unlikely that anyone would be allergic to MSM or sulfur, a naturally occurring substance in the body.


Find out how to make a brand new website without having programming knowledge with the help of the Online Website Builder.
Having a personal or a company website nowadays is becoming more and more popular, yet keeping your site up-to-date could be challenging when you travel a lot or you do not possess a PC and you have to visit Internet cafes. You cannot download and install web design software on every computer that you use, specifically if the application is paid or you simply have no permission to install anything. A great alternative in this situation is to use an online site design application, which you could access from any computer through a browser. In this way, you'll not need to download anything and it'll be much simpler to update your site and add new text or images. You will not have to worry about leaving the web site unattended because you will be able to access its back office even when you go on vacation assuming that there is any computer with any Internet browser around.
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If you purchase a semi-dedicated server from our company, you will be able to use Site Studio - an online site builder which we offer totally free with all internet hosting packages. The application comes with more than seventy web themes, each one with different styles and color schemes. Various pre-defined pages will make things so much easier as you won't need to create them on your own - Driving Directions or Resume, for example. You will be able to sign in to Site Studio through any device and from any place provided that you have access to an Internet browser, so you can update your web site even if you travel and you'll not need to download or install anything on your computer. If you work for several days, your visitors will not see an incomplete version of the site as the app saves all modifications, but doesn't publish them automatically. In this way, you can publish only the final version.


Visa support to Uzbekistan. Get online Visa and LOI to Uzbekistan free!
Process of obtaining Visa support and Letter of Invitation to Uzbekistan can easily pass with assistance of Peopletravel.
All tourists travelling to Uzbekistan must have valid Uzbekistan Visa and travel document.
An exception is made for citizens of CIS member countries who can travel to Uzbekistan with no Visa support or LOI. These countries are: Armenia, Azerbaijan, Belarus, Georgia, Kazakhstan, Kyrgyzstan, Moldova, the Russian Federation and the Ukraine.
On February 10, 2018, in Uzbekistan a visa-free regime for citizens of 7 countries was introduced for a period of 30 days. The countries are Israel, Indonesia, the Republic of Korea, Malaysia, Singapore, Turkey and Japan.
There is a list of countries, citizens of which may have a simplified obtaining of Uzbek tourist visa, visa free transit, temporary stay and departure from the Republic of Uzbekistan. The countries are Australia, Austria, Albania, Algeria, Andorra, Antigua and Barbuda, Argentina, the Bahamas, Barbados, Bahrain, Belize, Belgium, Bulgaria, Bosnia and Herzegovina, Brazil, Brunei Darussalam, Bhutan, the Vatican, Great Britain, Hungary, Venezuela, Vietnam, Gabon, Guyana, Guatemala, Germany, Honduras, Grenada, Greece, Denmark, Dominica, Dominican Republic, India, Ireland, Iceland, Spain, Italy, Canada, Qatar, Cyprus, China, Colombia, Costa Rica, Kuwait, Latvia, Lebanon, Lithuania, Liechtenstein, Luxembourg, Mauritius, Macedonia, Maldives, Malta, Morocco, Mexico, Monaco, Mongolia, Nauru, the Netherlands, New Zealand, Norway, the United Arab Emirates, Oman, Palau, Panama, Peru, Poland, Portugal, Romania, San Marino, Saudi Arabia, Seychelles, Saint Vincent and the Grenadines, Saint Kitts and Nevis, Saint Lucia, Serbia, Slovakia, Slovenia, the United States of America, Suriname, Thailand, Trinidad and Tobago, Tunisia, Turkmenistan, Uruguay, Fiji, Philippines, Finland, France, Croatia, Montenegro, Czech Republic, Chile, Switzerland, Sweden, Sri Lanka, Ecuador, Equatorial Guinea, Estonia, South Africa, Jamaica.
There is a list of countries, citizens of which are enrolled the procedure for issuing an electronic tourist visa to Uzbekistan. The countries are Australia, Austria, Albania, Andorra, Belgium, Bulgaria, Bosnia and Herzegovina, the Vatican, Great Britain, Hungary, Germany, Greece, Denmark, India, Ireland, Iceland, Spain, Italy, Canada, China, Kuwait, Latvia, Lithuania, Liechtenstein, Luxembourg, Macedonia, Malta, Monaco, the Netherlands, New Zealand, Norway, the United Arab Emirates, Oman, Poland, Portugal, Romania, San Marino, Saudi Arabia, Serbia, Slovakia, Slovenia, the United States of America, Thailand, Finland, France, Croatia, Montenegro, Czech Republic, Switzerland, Sweden, Estonia.
If your country is not in the list, you will need a letter of invitation to Uzbekistan (LOI), which Peopletravel provides you free of charge! The approval of visa support takes from 7 to 10 working days by the Ministry of Foreign Affairs of the Republic of Uzbekistan. The approved Letter of invitation to Uzbekistan is sent to the Embassy or Consulate of the place of issuance. If you are coming from a country where there is no Embassy or Consulate of the Republic of Uzbekistan, then you can obtain your visa at the Tashkent International Airport upon arrival.
Visa fee to Uzbekistan varies from USD 60-120, and consular fee may vary depending on the country of visa obtaining and your citizenship.
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Peopletravel – is not responsible for timing visa and Letter of Invitation approval by the Embassy, Consulate or MFA of the Republic of Uzbekistan; as well as if your LOI or visa is rejected by the Embassy, Consulate or MFA of the Republic of Uzbekistan.


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Tag Archives: murder mysteries
Philosophy Prof Pens Mystery Novels to Reach Millennial Thinkers
"PHILOSOPHY GIVES MEANING TO PEOPLE'S LIVES." Dr. Kelly Oliver believes that statement. It's why she feels privileged to teach philosophy at Vanderbilt University in Nashville, Tennessee. It's why she's written 20 scholarly nonfiction books and launched a millennial feminist noir mystery series featuring Jessica James, a young & wry philosophical cowgirl detective. "Writing novels, I start with some social issue, the same kind of social issues that motivate and inspire my nonfiction and my work in philosophy," Dr. Oliver explained. Her desire to write nonfiction books, like Hunting Girls: Sexual Violence from The Hunger Games to Campus Rape and Carceral Humanitarianism: Logics of Refugee Detention stems from the same inspirational impulse that generated Wolf, Coyote, and F.O.X. Dr. Kelly will reveal her creative process next week on The Studio with Cheryl on solar-powered KRUU.
Murder Mysteries, The Studio, What I'm Reading Today, Writing	murder mysteries
An Easy-to-Keep Resolution for 2013
Cedar Rapids, Iowa, Arts & Culture Professional Rob Cline
Rob Cline, my second guest on "The Studio," captured my attention by writing an article for The Iowa Source. His title–Reading Resolutions for 2013: Rob's 365 Short Stories–mesmerized me. Short stories are the genre I most love to read. Bookcases all over my house are stocked with books of short stories I bought during different eras in my life. I've read them all, but for years I've longed for the time and discipline to sit down and reread them. Many times I've thought, 'Wouldn't it be great to read a short story every single day?' Once I even taught a high school class where that's exactly what we did; the students and I silently read (then discussed) a different story–most were short, shorts–during each and every class. The stories the students wrote for that class surpassed many I'd seen from other writing students; could all that reading have made a difference? (Yes, is my guess.)
Well, here it is: day 26 of 2013, and I have Rob Cline to thank for the peaceful half-hour or so I've spent each day revisiting texts that feel like old friends from long ago. Right on target, today I finished Story #26 ("Returnings" by Tim Gatreaux). Honestly, I think this is one resolution I'm likely to keep straight on through to December 31st. Did you know June 21st, the longest day of the year, is International Short Story Day? Maybe that day I'll stage some kind of celebratory read-in for reaching the nearly-half-way-there point.
As it turns out Rob Cline does much more than sit around thinking up fantastic New Year's resolutions. As a Cedar Rapids Arts and Cultural Professional, he wears a lot of hats and they're all related to forging meaningful connections between artists and audiences. Rob earned a B.A. and an M.A. in Teaching with an emphasis in English, Philosophy and Secondary English Education at the University of Iowa. Specializing in marketing, writing, editing, and public speaking, he's currently the Director of Marketing and Communications for the University of Iowa's Hancher Auditorium, the Grants Manager of the Czech and Slovak Museum and Library in Cedar Rapids, and the Series Coordinator for Outloud, the Metro Library Network Author Series.
While maintaining these positions, Robb also somehow managed to write and self-publish a partially autobiographical mystery in 2012. Murder By the Slice features a pizza delivery driver whose hobby of devising rules of peaceful pizza delivery is interrupted by the murder of one of his customers. Tune in to learn more about Rob's 365 Short Stories project and his many other creative endeavors.
Murder by the Slice by Rob Cline
The Studio, Writing	free author interviews, murder mysteries, self-publishing
College Professor Pens Legal Thrillers
Mary Vermillion, Author of Seminal Murder
A Professor of English at Mount Mercy College in Cedar Rapids, Iowa, Mary Vermillion pens legal thrillers to highlight social issues. So far, she's written three books in her Mara Gilgannon mystery series. The fictional Mara, a radio talk show host, has gotten entangled in mysteries involving a small town resisting the opening of a new Walmart store and a rape charge involving college basketball players. Seminal Murder, the latest installment in the series, focuses on crimes taking place in an artificial insemination clinic.
Mary teaches a broad range of courses, including Shakespeare, Creative Writing, and Law and Literature. She and her students host book clubs with inmates at Anamosa State Penitentiary. Mary and a colleague recently toured England with students.
Mary will be featured Friday, Sept. 14th at 1 PM CT on "Writers Voices." The show will be rebroadcast Monday, Sept. 17 at 8 AM. Listen in at kruufm.com.
KRUU, Writers Voices, Writing	Mary Vermillion, murder mysteries

redpajama_set_name: RedPajamaCommonCrawl


Healthy Recipe: Alternative to Hash Browns!
Add the cauliflower; cook and stir until the cauliflower is tender and nicely browned all over. You can add a couple tablespoons of butter during cooking to speed up browning and add flavor. Season to taste with salt and pepper.


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January Wash, an arroyo, tributary to El Dorado Canyon, in Clark County, Nevada. Its mouth is located at its confluence with El Dorado Canyon at an elevation of 2375 feet.  Its source in the Eldorado Mountains near the Rich Hill Mine at .

References

Rivers of Clark County, Nevada
Washes of Nevada

redpajama_set_name: RedPajamaWikipedia


Is There Value in Corporate Values?
For any business experiencing growing pains, the following question is certain to arise: Is there any benefit in defining company values?
Looking at PaySmart's own experience of growth, I believe corporate values are an absolute pillar for ongoing success. Like PaySmart, many SMEs begin life as an intimate, family-owned business. Those that thrive and expand can risk losing their family culture as the day-to-day running of the business takes over.
Without defined values however, it's difficult to have a strong culture. And culture is the heartbeat of your customer service ethic, your brand, and your ability to attract great talent.
As highlighted in a recent Forbes article, employees are increasingly looking for companies that provide a supportive, motivating, team-focused and fun environment. At Twitter for example, staff appreciate the emphasis on 'open dialogue' and 'fearless communication'. At Chevron, employees put 'safety first' and always look out for one another.
Conduct appraisals based on both KPIs and values.
Engage your senior managers in regularly 'walking the talk' and communicating the desired behaviours with their teams. And importantly, remember to acknowledge or reward those behaviours.
If you have any other thoughts to contribute, I welcome you to join this conversation.


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north american fish species
Gars are known to bask like logs and breathe air. ... Micro species are fish that don't get big enough to be a standard … In this study, we established a barcode reference library for more than 80% of the named freshwater fish species of North America. Trolling with a heavy line, fighting belt, fishing chair, and deck hands is highly recommended. Anagram Word Building VIII 7,490; Find the US States - No Outlines Minefield 7,222; Bordering 'C' Countries on a Map 6,567; Oscar Winner AND IMDb Top 250 … Family: Ictaluridae North American freshwater catfishes (See list of species below) Select Class: Popular Quizzes Today. Large Cobia are often caught at night but can be caught throughout the day as well. If there is a species missing that you think deserves to be in this list then please let us know in a comment below. The Flathead's genus … North American native fish species are not really tough keepers but just fish that have a slightly different set of requirements than the tropicals we know and love. There are nearly 1,000 species of freshwater fishes in North America alone, and identifying them can sometimes be a daunting task. Rod - 7-9 foot spinning rod with medium action, Fishing Line - 30 lb braid line with a 60 lb mono leader, The most popular bait for Roosterfish are livebait like mullet and bonito, 6-7 inch poppers and stickbait are also effective. North America has the most diverse nontropical freshwater fish fauna in the world (Lundberg etal. Crappie are found in hundreds of lakes throughout the United States, Look for crappie around deep timber in winter, As spring increases the water temperature crappie move to shallow coves to spawn. Gars are known to bask like logs and breathe air. Saved by Carlita. This website provides access to the list of imperiled freshwater and diadromous fishes of North America as determined by the 2008 American Fisheries Society (AFS) Endangered Species Committee (ESC) on Fishes. Fossil records of this group trace its existence back to the 'early Cretaceous era' of over 100 million years ago. Species: American Eel, Burbot, Freshwater Drum, Sculpins, Sleepers, ... roughfish.com is primarily dedicated to angling for freshwater species in North America, but we list … The United States is abundant with species of fish that anglers love, but it can be difficult to get the right gear if you want to target multiple species. … Bluegill are a widely distributed freshwater panfish. Look for birds - this often highlights a bait ball that tuna feeding under the water have created. North American catfishes also have stout spines at the origin of their dorsal and pectoral fins. Bluegill. They average 6 inches to 8 inches, … Reel - Medium to Heavy 5000-8000 sized Spinning Reel, Fishing Line - 12-15 lb mono line with a wire trace, The best bait for pike are minnows for small pike and live perch for large pike as well as spinnerbaits and spoons. Fish Identification: Find Species. They can be 11.2 ft. in length and up to 450 kg in weight. Sheefish: Alaska, Northwestern Canada. For this reason, micro fish species don't count for contests or for official lifelists. The giant snakehead is a voracious predator with sharp teeth, a large mouth, and strong jaws. Although the most common is large lakes, slow moving rivers, and reservoirs - they are also found in ditches, canals, and small ponds. There is talk of horrible scenarios such as native animal species being wiped out by the fish. A 3-pounder is trophy size, but a 1-pounder is more common and can be … Just yesterday I've heard for Sheepshead and Scup. One good bait species is the bluntnose minnow (P. notatus), an olive-coloured … Look for carp breaching the surface to identify their position and then fish in that area, The most common baits for carp are corn, bread, boilies, and doughball - these can be homemade or bought. Gar, any of seven species of large North American fishes in the genera Atractosteus and Lepisosteus, in the family Lepisosteidae. Compatibility and Feeding of North American Native Fishes in Aquaria. Carp are extremely hardy and can live in all kinds of environments. How to Play Forced Order. Rod - Ultralight fast action spinning rod, Perch are not picky eaters and some popular baits are minnows. All in all, there are 11 species of Trout in North America: Two Pacific Trouts: Cutthroat and Rainbow Trout. Awaous banana. Go fishing, have fun, and learn more about fish species in North America with our handy list! All you need is a keen eye, and know which places to visit and before you know it, you will be hooking this trophy fish, Some popular locations are the Madison Chain, Green Bay, and Lake Onalaska. Over 700 species of freshwater fish are found in the U.S., and as you'd imagine, more than a few of them are suitable for the home tank. Two North American species are the yellow shiner, or Notemigonus crysoleucas, and the redfin shiner or Notropis umbratilis. Bowfin. On the other hand, if you've already caught something while you were out fishing and are asking, "What kind of fish is this?" consider using our fish identification chart and the database together to find exactly what it is. Nearly 40% of the fish species in freshwater habitats are in some level of imperilment. Sailfish are one of the worlds most popular gamefish and can be found in tropical offshore locations like Mexico, Florida, and Costa Rica. More than 145 non-native freshwater fish species have been recorded from Florida since the 1880s. Always try opting for a natural food source for the fish such as dead baits. It's been called a \"frankenfish\" due to its aggressive reputation. Barracuda are found in tropical offshore waters from Florida to Massachusetts. ... Snakeheads are air-breathing freshwater fishes that are not native to North America. The quota has been allotted to the fishermen using line fishing, pots, and trawls. North American Invasive Aquatic Plants and Animals in Ponds, Lakes and Streams. This article on freshwater fish by the US Fish and Wildlife Service is also very helpful if you are looking for more information. Snakeheads are predatory fish that have some surprising characteristics. 5. Gar, any of seven species of large North American fishes in the genera Atractosteus and Lepisosteus, in the family Lepisosteidae. They do not grow big. Popular Quizzes Today. Worms and nightcrawlers are popular bait for bluegill as well as crickets and grasshoppers. Reel - spinning or baitcasting reel with high maximum drag. Posted by: Chewy Editorial. This is an artform that many charter captains have mastered. by Scuadrado Plays Quiz Updated Dec 18, 2018 . Rod - 6 to 7 foot medium action spinning rod like an Ugly Stik GX2, Reel - Light to medium weight 2000-3000 size spinning reel, The most popular bait for redfish is fresh mullet as well as artificial crankbaits, There are plenty of locations in the northern United States if you want to go for pike fishing. The Longnose Gar is a primitive freshwater fish found along the eastern … Please take micro fish species listings with a huge grain of salt as none of them should be considered official or correct. If you are fishing around mangroves then chum the water with pilchards before casting towards the structure. There are many species of dace including the blacknose, longnose, redbelly, pearl, redside, rosyside, and... Darters. It's time to go fish! Don't set the hook, let the fish take the bait themselves. Until you find the ideal location, start off with a mix of trolling and casting. The Ictaluridae Catfish family is also known as the North American freshwater Catfishes. Please take micro fish species listings with a huge grain of salt as none of them should be considered official or correct. Walleye often hide around rocky points and sand bars as well as weed banks and reefs. Robyn's North American Native Fish Page Catfish. Mahi Mahi are found in tropical and subtropical oceans in the Gulf of California and from New Jersey to Florida, They are surface dwellers and are often caught close to the surface, Mahi Mahi can be caught trolling, spinning, using live bait, and dead bait, Rod - 7 foot long conventional boat fishing rod, Reel - Conventional boat fishing reel with 20 lb of drag, Fishing Line - 30 lb braid line with 50 lb fluoro leader, Popular baits for Mahi Mahi are sardines, mackerel, shrimp, and ballyhoo, They can also be caught with skirted troll lures. To help with this we have put together a guide to show common North Amercian Fish Species for Anglers, how to catch them, recommended gear, and popular bait so you can select the right equipment for your local area. Russ writes reviews for all of his fishing gear to help others achieve their own fishing goals. Just behind this group are the cold-water trout and salmon species. Rod - 6-7 foot spinning medium action rod, Fishing Line - 8-12 lb mono line with wire leader, Use fast moving lures, stickbaits or cut mackerel. At the end of 2010, the freshwater fish fauna of North America consisted of 53 families, 214 genera, and 1213 species, or about 8.9% of the Earth's freshwater fish diversity (Nelson etal. Just behind this group are the cold-water trout and salmon species. Panfish in the form of crappies and bluegills take a close 2nd place. Rod - 7 foot medium to medium-heavy power with moderate-fast action spinning or baitcasting rod. Learn more about your world and the cool types of fishes with pictures and names! The fish have no natural predators. Rod - 6-7 foot spinning or conventional medium action rod, Reel - 6000 size spinning reel or a light offshore conventional reel, Fishing Line - 15 lb braid or 15 lb mono line, One of the best baits for mackerel is actually other mackerel strips as well as garfish, scad, sand eels, and squid. I've heard for Lady Fish too. Like bluegills, smaller ones are cooked whole, and larger ones can be filleted. Tuna schools are very mobile and can often disappear at a moments notice, so be ready to move as soon as they vanish. North American native fish species are not really tough keepers but just fish that have a slightly different set of requirements than the tropicals we know and love. Barracuda are very territorial and aggressive, so if you put a tempting or threatening bait or lure near them they are very likely to strike. Synthetic bait like Leland Lures Crappie Magnet work well. Put out 3-4 different types of bait at the start to figure out what the tarpon are hungry for. 2000). Obviously this only shows a brief summary of each fish - have a look at our individual fish tips for more detailed information. 6 Northern Pike Fishing Tips [2020 Update]. North America - Fish Identification Chart. Of 28 native species and subspecies of U.S. trout, three are extinct and 13 of the others occupy less than a quarter of their historic habitat, reports Trout Unlimited. According to angler surveys, largemouth and smallmouth bass are America's most popular fish. A very popular food fish in the South and a species widely found in the United States, crappie has sweet white meat. These species have been the focus of much study recently, as researchers have sought to determine the relationships among species that appear to have evolved very recently. According to the Endangered Species Committee of the American Fisheries Society (AFS), 40 percent of North America's freshwater fish species are imperiled or already extinct. Rd., Cherokee Co., GA 51 mm SL, Collected 11-September 1982. Alligator gar. No matter which coast you're on or which lake you're near, there's a humble ecosystem of amazing creatures. ... White bass can be found in many North American lakes and rivers. When you identify a prime location then drop bait down to the target depth. Feature Image: By Brian … Look for thin, silver fish on sand banks, drop offs, and weed beds. The fish is an important food species in America, but the government highly regulates its fishing. In scientific terms, snakeheads are divided into two distinct genera: Channa … Look out for their distinctive dorsal fin. The yellow shiner, also called the golden shiner, grows to a foot long but the redfin shiner grows to 3 inches long, like most shiners and minnows. Troll past the hot zone with a skirted trolling lure and reflective teasers. Redfish. Gars are related to the bowfin and are confined chiefly to fresh water, but some species descend to brackish or even salt water. The sheefish is the world's largest type of whitefish, and … We've created a helpful list of different kinds of fish of North America, from the humble catfish to the rare golden trout to the beautiful giant oarfish! The presence of wild snakeheads in North America worries some conservation officers and officials very much. Fossil records of this group trace its existence back to the 'early Cretaceous era' of over 100 million years ago. The American alligator is the bigger. American Oddballs. Catfishes are stout, muscular fish that use their incredible sense of smell to locate their prey. According to the information, the 'alligator gar' is among the largest freshwater fish species in North America. They are a pelagic species which means they are found in the top water column around schools of bait fish. At the end of 2010, the freshwater fish fauna of North America consisted of 53 families, 214 genera, and 1213 species, or about 8.9% of the Earth's freshwater fish diversity (Nelson et al. In scientific terms, snakeheads are divided into two distinct genera: Channa … According to the information, the 'alligator gar' is among the largest freshwater fish species in North America. American shad. When you see a school of tarpon with a good pair of polarized sunglasses, drift with your boat, and cast to the other side of the school, slowly retrieving your lure or. We've created a helpful list of different kinds of fish of North America, from the humble catfish to the rare golden trout to the beautiful giant oarfish! Cambarellus patzcuarensis, Mexican Dwarf Orange Crayfish: Order: Wholesale quantities available: Price: $12.00: $8.00: Lepisosteus platyrhincus, Florida gar Compatibility: Order: 8 inch. More than 145 non-native freshwater fish species have been recorded from Florida since the 1880s. No matter which coast you're on or which lake you're near, there's a humble ecosystem of amazing creatures. conservation officers identify fish that have been filleted or skinned. Wahoo are often caught when anglers are chasing other gamefish like marlin and are attracted to similar styles and sizes of trolling lures. Catfish take up the 3rd spot, followed by the walleye's huge following in the north country. It travels over land with a wriggling motion and moves up to a quarter of a mile to reach a new waterway. With 49 species, Ictaluridae, the Bullhead Catfish family is the largest family of freshwater fishes endemic to North America. Mar 20, 2014 - North America - Fish Identification Chart.. Kayak Fishing. … Most fish species can be split up into a few categories - freshwater, saltwater, and big gamefish. It has a lung-like organ in addition to gills and can breathe in air. This different types of fish list shows where each fish species comes from as well as which state has made it its official state fish. Of course, freshwater fish of North America have such a variety that it's very important to keep in mind your location! Phew - that brings us to the end of this overview on North America Fish Species. Many people believe the natural environment is safe from the non-native plants … Species: American Eel, Burbot, Freshwater Drum, Sculpins, Sleepers, ... roughfish.com is primarily dedicated to angling for freshwater species in North America, but we list … Freshwater Fish of America. Reel - Large conventional reel with hundreds of yards of spool capacity to fight a speeding sailfish, Fishing Line - 30 lb mono with 80 lb mono leader. Brook ... C. California roach. Bonytail chub. Our list of fish names and pictures is in alphabetical order and can give an inkling of the huge variety of fish types there are in America. Adjust your depth and position based on the season. Frying is most common. Two known hybrids: Splake and Tiger Trout. Almost all the Central and North American cichlids are monogamous substrate breeders. These sunfish are freshwater ray-finned fish. The North American Native Fishes Association is dedicated to the appreciation, study and conservation of North America's native fishes. The term cisco is also specifically used of the North American species Coregonus artedi, also known as lake herring. Line - 10-12 lb mono with a 20-30 lb fluoro leaders, Carp are often found hiding in the deeper water near drop offs or shelves. Worldwide, the number is over 10,000 species. Anagram Word Building VIII 7,490; Find the US States - No Outlines Minefield 7,222; Bordering 'C' Countries on a Map 6,567; Oscar Winner AND IMDb Top 250 … From Sockeye to King, Masu to Danube, Lake Trout to Arctic Char, Brown Trout to Cutthroat, Rainbow Trout, Atlantic Salmon, and many more, this poster gives you pictures of each fish (many in both genders as well as ocean form), official species names, maximum weights… Use a smaller trolling lure that can move fast through the water behind your boat. In fact, in just the twenty years since publication of the first edition of the Peterson Field Guide to Freshwater Fishes, the number of species has risen by almost 150, including 19 marine invaders and 16 newly established nonnative species. For this reason, micro fish species don't count for contests or for official lifelists. At the end of 2010, the freshwater fish fauna of North America consisted of 53 families, 214 genera, and 1213 species, or about 8.9% of the Earth's freshwater fish diversity (Nelson etal. Two known hybrids: Splake and Tiger Trout. Roosterfish put up a big fish for their weight and can fight for 30-45 minutes until their are landed. Invasive Pond Plants invasive pond plants used by invasive garden pond plant retailers. Our knowledge of North American fishes is facilitated by a long tradition of faunal study and public access to most river and lake systems. Four Chars: Brook, Bull, Dolly Varden, and Lake Trout. Snook can be found in fresh and saltwater generally around mangroves, docks, bridges, and other structure. His dream is to catch a Black Marlin. Reel - 5000-8000 size heavy spinning reel with 30 lbs of drag, Fishing Line - 80 lb mono line with wire leader, Wahoo are normally caught using a trolling lure. Can you pick the North American freshwater fish species shown? There are more than 800 known freshwater fish species in North America alone. They school near the shore. Bluegill are a widely distributed freshwater panfish. We offer our thoughts as a partial explaination. Look for Perch on your fish finder towards the bottom of the lake. They are an extremely popular and widely distributed... 2) Bluegill Mar 20, 2014 - North America - Fish Identification Chart. Here you can post everything you know about salt water fish species around North American continent (east coast, west coast and gulf of Mexico): So far I know only few: Bluefish and Striped Bass were first I've learnt relatively recently. Because they hang around structure there is a risk of breaking line so you will want to use slightly heavier gear than you would expect. So, they are only... Dace. North and Central American Cichlids Together with the South American cichlids, the Central and North American cichlids form a group known as New World Cichlids. These range from species observed only once to species with established permanent populations in several locations across the state. This website provides access to the list of imperiled freshwater and diadromous fishes of North America as determined by the 2008 American Fisheries Society (AFS) Endangered Species Committee (ESC) on Fishes. American eel. Reel - A medium-heavy 5000-8000 size spinning reel, Fishing Line - 30-50 lb braid with 30-50 lb mono leader, Popular natural bait for Cobia are plastic swimming eel, plastic crabs, fish, and livebait. From 1970 through 2010, species documentation averaged 6.7 species described per year, which is considered the modern rate of fauna… Catfish can be caught all year round but are most active in late spring and summer. Of the 40 species found north of Mexico, 13 are known to live in Pennsylvania. His favorite reel is a Shimano Tyrnos for an overhead reel or a Shimano Curado for a baitcaster. Generally freshwater fish are smaller and require lighter gear than saltwater fish. Rod - Medium action 8 foot long spinning rod, Fishing Line - 20-30 lb braid line with 20-30 lb mono leader, The best bait for snook are shrimp and sardines. Mar 20, 2014 - North America - Fish Identification Chart. They are predatory fish who are also territorial. American alligators have long, rounded snout, flat tail, and short legs. Aulorhynchus. Arctic grayling. Cool water, a large aquarium, plenty of fish food and frequent partial water changes are all part of the equation that leads to successfully housing these unique native fishes. They stay close to shore and hide around structure like bridges, banks, and weed beds. The North American Native Fishes Association is dedicated to the appreciation, study and conservation of North America's native fishes. The fish is able to survive out of water for several days. ... Total number of fish in your order including all species combined: Species : 1 - 6 Fish total for order: 7 or More Fish. There are nearly 1,000 species of freshwater fishes in North America alone, and identifying them can sometimes be a daunting task. Beavers are large, semiaquatic rodents of the temperate Northern Hemisphere.There are two extant species in the genus Castor, the North American beaver (Castor canadensis) and the Eurasian beaver (C. fiber).Beavers are the second largest living rodents after the capybaras.They have stout bodies with large heads, long chisel-like incisors, brown or gray fur, hand-like front feet, webbed back feet and flat, … ... Total number of fish in your order including all species combined: Species : 1 - 6 Fish total for order: 7 or More Fish. 1) Crappie Fossil records of this group trace its existence back to the 'early Cretaceous era' of over 100 million years ago. Several states and provinces in- cluding Alaska, Colorado, Florida, Idaho, Iowa, Michigan, You'll have a much better idea of what you've caught if you look up what the local species are in Alaska as opposed to Florida or Lake Michigan. Russ is an avid angler. Look for local bugs and match them like crickets or fresh minnows. The most popular bait for walleye fishing is minnows, leaches, and night-crawlers. North American Fish Species for Anglers [2020 Edition]. Catfishes are distinguished by their many barbels, or whiskers, and their lack of scales. The golden shiner is a common bait fish. A. Alewife (fish) Amyzon (fish) Apeltes. North and Central American Cichlids Together with the South American cichlids, the Central and North American cichlids form a group known as New World Cichlids. Freshwater fish face threats from human activity, such as overfishing, marine pollution, habitat loss, dam building, and the introduction of invasive species. In this study, we established a barcode reference library for more than 80% of the named freshwater fish species of North America. Catfish take up the 3rd spot, followed by the walleye's huge following in the north country. The Flathead's genus … Compatibility and Feeding of North American Native Fishes in Aquaria. Cast your crankbait to the edge of the sea weed to entice the bass out from their hiding spot. Blackfin sorcerer. NORTH AMERICAN CATFISHES FAMILY ICTALURIDAE FAMILY OVERVIEW. 2004). According to the information, the 'alligator gar' is among the largest freshwater fish species in North America. Campostoma. Reel - Spinning or Baitcasting reel with around a 6.4:1 gear ratio, Rod - Spinning or Baitcasting rod around 6-7" long with a fast action and medium power, Trout are prized among fly fisherman but can be caught with a normal spinning rod and reel, Rod - Ultralight 7 foot rod with a fast action, Reel - Ultralight spinning reel or fly fishing reel, Popular natural bait for trout are worms, minnows, maggots, Salmon are popular amongst fly fisherman but can be caught with a spinning reel as well, Salmon eggs, herring and sand shrimp are popular natural baits for salmon. We offer our thoughts as a partial explaination. Because of this, scent-based baits are popular for catfish anglers, and secret arcane concoctions that give off noxious odors are their stock in trade. Tarpon is one of the most popular fishing species in Florida. 2004). There has not been enough evidence indicating the need to list the fish as one of the endangered species in the country. Unlike the South American cichlids, a majority of the Central and North American cichlids originates from one single lineage – the Cichlasomine. Reel - Heavy conventional offshore reel with 40 lb of drag, Fishing Line - 60 - 80 lb braid line with 130 lb mono leader, Lamprey, smelt, squid, and nightcrawlers are popular natural bait for Sturgeon. According to angler surveys, largemouth and smallmouth bass are America's most popular fish. Pages in category "Fish of North America". Be prepared for the fish to break free - fisherman often talk about how many tarpon they jumped rather than landed as it is very difficult to bring them all the way to the boat. We couldn't include every possible fish species in this list but will be updating it in the future. Privacy Policy, 50 Fish Species of North America: The A to Z of Local Fish, 32, 40, 50 and 60 Wide Metal Building Prices. Rate 5 stars Rate 4 stars Rate 3 stars Rate 2 stars Rate 1 star . Most North American catfish grow very large and eat whatever they can fit in their mouths. Almost all the Central and North American cichlids are monogamous substrate breeders. Bring plenty of extra lures as the barracuda's teeth can do some damage to your lures. Perch are often found in warmer, shallow waters in spring, but head deeper to 20-25 feet in summer. From huge sharks to tiny sticklebacks, there are all kinds of fish in America! Use a skirted trolling lure with several teasers to lure the marlin to the surface. Roosterfish are found from Baja to Ecuador on sandy bottoms near baitfish. Redfish or Red Drum are widespread from Texas to Florida. Have a read through our guide below, find the fish that live in your local areas and you should be able to get a clear idea of what equipment you will need. Best 10 Portable Ice Fishing Shelters [2020 Update], Best 10 Ice Fishing Augers [2020 Reviews], Best 10 Ice Fishing Tip-ups [2020 Update]. One European Trout: Brown Trout. Gamefish are in a world of their own and requires dedicated, specialist equipment that can be very heavy and expensive. This trout species may be a favorite among fishermen, but it's not necessarily a favorite among other fish. North American freshwater catfish; Red sea catfish; Central mudminnow; Central stoneroller; Channel darter; Chiselmouth; Arroyo chub; Chihuahua chub; Humpback chub; Lake chub; Coastrange sculpin; Common carp; Common shiner; Coregonus artedi; Creek chubsucker; Cyprinella; Cyprinella spiloptera; Cyprinodon desquamator Copyright © 2003-2020 Alan's Factory Outlet All Rights Reserved. The American alligator is also the largest reptile of North America. Redfish or Red Drum are widespread from Texas to Florida. You can also try a topwater lure to see the fish strike with scary power. Identification pictures can help, but you can also use the fish species database to find the exact fish you're looking for. Identify the position of a potential target by observing their noticeable sail movement around a school of bait fish. Posted by: Chewy Editorial. Look for the marlin surfaced in the distance or driving up baitfish then head in that direction. We used this survey of standing genetic diversity as an independent calibration of current taxonomic resolution within the North American fish fauna to reveal key areas of uncertainty where discrepancies between genetic data and morphologically based … by Scuadrado Plays Quiz Updated Dec 18, 2018 . Here you can post everything you know about salt water fish species around North American continent (east coast, west coast and gulf of Mexico): So far I know only few: Bluefish and Striped Bass were first I've learnt relatively recently. From huge sharks to tiny sticklebacks, there are all kinds of fish in America! Of the 40 species found north of Mexico, 13 are known to live in Pennsylvania. Apache trout. There are only two known species of alligators in the world – American Alligator and Chinese alligator. Set three lines with livebait at different depths to identify the depth that catfish are travelling and then focus when you narrow it down. Thus, this exotic virus is considered a potential threat to native and cultured fish populations in North America. a fish in eastern North America in both salt and fresh water A fine & interesting book about the SHAD is "The Founding Fish" by John McPhee, 2002. Four Chars: Brook, Bull, Dolly Varden, and Lake Trout. Reel - Large conventional reel with over 500 yards of 80 lb mono line capacity and high maximum drag with a low gear ratio, Fishing Line - 80 - 100 lb braid line with heavy leader. Links: A Listing of scheduled Focus On Nature Tours Upcoming Focus On Nature Tours in North America. Unlike the South American cichlids, a majority of the Central and North American cichlids originates from one single lineage – the Cichlasomine. All in all, there are 11 species of Trout in North America: Two Pacific Trouts: Cutthroat and Rainbow Trout. Keep your eyes open for redfish tailing - this occurs when a redfish is bottom feeding in shallow water and their tails come out of the water. Family: Ictaluridae North American freshwater catfishes (See list of species below) Select Class: How to Play Forced Order. North American (or Bullhead) Catfishes Photo by Richard T. Bryant & Wayne C. Starnes Etowah R., just above Yellow Cr. From 1758 to 2010, the average rate of fish descriptions for North America was 4.8 species described per year, but as is evident in figure 1a, the rates varied over time and logically increased as more biologists studied the fauna. Kayak Fishing Fishing Boats Fishing Stuff Fish Chart Field Guide Environmental Science Freshwater Fish Survival Prepping Natural History. Many people believe the natural environment is safe from the non-native plants … We used this survey of standing genetic diversity as an independent calibration of current taxonomic resolution within the North American fish fauna to reveal key areas of uncertainty where discrepancies between genetic data and morphologically based … Some people wonder why there is such a fuss over invasive aquatic species of plants and animals. The North American cyprinid minnows comprise numerous species of small freshwater fishes that are known by such names as shiner (genera Notemigonus and Notropis) and bluntnose and fathead minnow (Pimephales).Many are abundant, and a number are valuable as live bait; sometimes they are cultured for this purpose. Rod - A heavy conventional boating rod on the stiff side, Reel - A serious conventional offshore reel with 35-60 pounds of drag, Fishing Line - 30 lb braid line with fluorocarbon leader, Some of the most popular baits for tuna are herring, mullet, squid, mackerel, or skipjack. The Ictaluridae Catfish family is also known as the North American freshwater Catfishes. Basketweave cusk-eel. Look for bass around structure or weed beds. AFS calls these declines "a major tragedy" … Crappie are the largest fish in the panfish group. Save my name, email, and website in this browser for the next time I comment. Fish Identification: Find Species. Many North American freshwater gamefish and those caught by commercial fishermen are included. Blue catfish. The sunfish are very popular among kids, anglers and professional sport fisherman. Cambarellus patzcuarensis, Mexican Dwarf Orange Crayfish: Order: Wholesale quantities available: Price: $12.00: $8.00: Lepisosteus platyrhincus, Florida gar Compatibility: Order: 8 inch. NORTH AMERICAN CATFISHES FAMILY ICTALURIDAE FAMILY OVERVIEW. Rod - 6'6" to 7' medium action spinning reel. Hopefully you have gained some knowledge about the most common angling species. One European Trout: Brown Trout. The Sunfish are a family of fresh water species that are native to North America. We've also pointed out the types of freshwater fish in America versus the types of saltwater fish. Our goal was to collect six fish of each species for measurement purposes. Cool water, a large aquarium, plenty of fish food and frequent partial water changes are all part of the equation that leads to successfully housing these unique native fishes. Redfish are popular among anglers because they habitat so many different environments and you can find them just about anywhere. Large catfish often stay in deep holes next to underwater ledges. Catfishes are stout, muscular fish that use their incredible sense of smell to locate their prey. American Oddballs. Nearly 40% of the fish species in freshwater habitats are in some level of imperilment. Retrieve your lure as fast as possible - you won't be able to retrieve faster than a tuna can swim! Since the first North American outbreak of SVCV at a North Carolina koi farm in 2002 there have been eight subsequent detections or outbreaks of SVCV among fish species from the families of Cyprinidae and Centrarchidae within the US and Canada. Blackear wrasse. Just yesterday I've heard for Sheepshead and Scup. ... Snakeheads are air-breathing freshwater fishes that are not native to North America. Rate 5 stars Rate 4 stars Rate 3 stars Rate 2 stars Rate 1 star . Longnose Gar. … Reel - A spinning reel with 250-300 lbs of line capacity, Fishing Line - 50-80 lb braid line with 60-80 lb mono leader, The most popular bait for tarpon is live baitfish including pilchards, pinfish, minnows, and herring. Blue sucker. I've heard for Lady Fish too. Gars are related to the bowfin and are confined chiefly to fresh water, but some species descend to brackish or even salt water. Some species has been introduced in other countries but they are all native to North America. Bluefish. Bullhead catfishes are easy to recognize from other North American freshwater … Feature Image: By Brian … These range from species observed only once to species with established permanent populations in several locations across the state. Invasive Pond Plants invasive pond plants used by invasive garden pond plant retailers. Panfish in the form of crappies and bluegills take a close 2nd place. 2004). Redfish are popular among … North American catfishes also have stout spines at the origin of their dorsal and pectoral fins. North American Invasive Aquatic Plants and Animals in Ponds, Lakes and Streams. He has fished all over the world, primarily for Saltwater game fish but also for local prize fish. Can you pick the North American freshwater fish species shown? Some people wonder why there is such a fuss over invasive aquatic species of plants and animals. B. Barcheek pipefish. We are a participant in the Amazon Services LLC Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites. Over 700 species of freshwater fish are found in the U.S., and as you'd imagine, more than a few of them are suitable for the home tank.
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north american fish species 2020


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Home › Press
Frick Collection to Present Major Turner Exhibition in 2017
February 23 through May 14, 2017
Joseph Mallord William Turner (1775–1851), Britain's greatest land- and seascape artist during the nineteenth-century, took an interest in the subject of ports throughout his career, both in monumental oil paintings and in watercolors. An insatiable traveler and an artist with a deep fascination with light, topography, local traditions, and classical antiquity, Turner brought an innovative approach to the depiction of both modern and ancient ports. In the spring of 2017, The Frick Collection will present Turner's Modern and Ancient Ports: Passages through Time, a major exhibition that brings together some thirty-five works from the 1810s to the late 1830s. The works— in oil, watercolor, and graphite—capture contemporary cities in England, France, and Germany, as well as imagined scenes set in the ancient world. Turner's Modern and Ancient Ports: Passages through Time is organized by Susan Grace Galassi, Senior Curator at The Frick Collection; leading Turner scholar, Ian Warrell; and Joanna Sheers Seidenstein, the Frick's Anne L. Poulet Curatorial Fellow. Principal funding for the exhibition is provided by The Honorable and Mrs. W. L. Lyons Brown. Additional support is generously provided the Peter Jay Sharp Foundation, Gilbert and Ildiko Butler, Helen-Mae and Seymour R. Askin, Margot and Jerry Bogert, George and Michael Eberstadt in memory of Vera and Walter Eberstadt, Francis Finlay, and The Gladys Krieble Delmas Foundation. The exhibition catalogue is underwritten by a gift from an anonymous donor in memory of Charles Ryskamp.
The springboard for this show is a pair of monumental paintings by Turner in The Frick Collection acquired by the museum's founder over a century ago—the Harbor of Dieppe of 1825 and Cologne, The Arrival of a Packet-Boat: Evening of 1826. Due to travel restrictions, however, they have never before been part of an exhibition outside of the Frick. While they are widely recognized as significant turning points in the artist's career, a focused examination of these works is long overdue and will provide an ideal occasion to consider afresh one of the central motifs of Turner's art. This exhibition will also unite for the first time Dieppe and Cologne with a closely related, yet unfinished, work from Tate Britain that depicts the modern harbor of Brest. As supported by recent technical analysis, The Harbor of Brest was likely intended to form a series of monumental European ports with the two Frick paintings. This trio of canvases—all made at a time when Turner was experimenting with the representation of light—offers a fascinating glimpse into his technique as well as the everyday life of major European ports of distinctly different regions. Displayed alongside these paintings will be two sketchbooks filled with drawings made on site by Turner during his travels to the Continent, the material from which he later developed his canvases.
The exhibition also features three oil paintings from the later 1820s and 1830s in which Turner continues to explore the motif of the port, now as a setting for narrative scenes drawn from classical history: Regulus (London, Tate Britain); Ancient Italy: Ovid Banished from Rome (private collection); and Ancient Rome: Agrippina Landing with the Ashes of Germanicus (London, Tate Britain). These evocations of ancient Rome and Carthage share with the artist's modern ports their compositional format—a central expanse of water, with land on either side, beneath a luminous sky—and their array of quotidian detail—the same variety of mundane objects and figures at work and at leisure that appear in the Harbor of Dieppe and Cologne—now evoking the daily life of a long bygone era. Into these light-filled and richly detailed scenes, Turner integrates his narrative content—momentous scenes of arrival and departure that look forward and back. The close relationship of Turner's modern and ancient ports reveals the extent to which observation and imagination overlap in his process.
Central to the exhibition are a selection of some two-dozen of Turner's watercolors from these same years, often made for series of prints for a bourgeoning class of leisure travelers in the post-Napoleonic era. Representing port towns and cities along the various waterways of the British Isles and Continental Europe, these dazzling small-scale works share with the grand harbors of the 1820s their picturesque subject matter and formal qualities of composition and color. The breathtaking effects of light and color that Turner achieved in watercolor, in fact, informed his work on canvas, resulting in a freer approach to his use of materials and painting technique, as seen in the Frick pictures and in the ancient scenes.
In the accompanying catalogue, the Frick paintings and a wide selection of works by Turner from the 1820s and 1830s, depicting both modern and ancient harbors, are examined in various contexts. Drawing from contemporary travel accounts, literary and visual sources, and critical reviews, as well as new technical analyses of Turner's work, the five essays present a fresh perspective on the middle years of the artist's career. The book will feature essays by the show's curators as well Gillian Forrester, Senior Curator of Prints and Drawings, Yale Center for British Art; and Rebecca Hellen, Conservator of Paintings, Tate Britain; and Joanna Sheers Seidenstein, Anne L. Poulet Curatorial Fellow, The Frick Collection. Among the topics addressed are the radical changes in the social and economic structures of Britain in the first half of the nineteenth century; the rediscovery of the Continent by the British after Waterloo following two decades of war with France; the rise of mass tourism; Turner's involvement in producing watercolors for various print series; and the interconnection between his manner of painting in various media.
British Painting
General Information Phone:
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Museum Entrance:
1 East 70th Street, near Fifth Avenue
Open six days a week: 10:00 a.m. to 6:00 p.m. on Tuesdays through Saturdays; 11:00 a.m. to 5:00 p.m. on Sundays. Closed Mondays, New Year's Day, Independence Day, Thanksgiving, and Christmas Day. Limited hours (11:00 a.m. to 5:00 p.m.) on Lincoln's Birthday, Election Day, and Veterans Day.
PLEASE NOTE TO YOUR READERS: Children under ten are not admitted to the Collection.
Museum Admission:
$22; senior citizens $17; students $12; "pay what you wish" on Sundays from 11:00 a.m. to 1:00 p.m.
Subway:
#6 local (on Lexington Avenue) to 68th Street station; Bus: M1, M2, M3, and M4 southbound on Fifth Avenue to 72nd Street and northbound on Madison Avenue to 70th Street.
Included in the price of admission is an Acoustiguide Audio Tour of the permanent collection. The tour is offered in six languages: English, French, German, Italian, Japanese, and Spanish.
The shop is open the same days as the Museum, closing fifteen minutes before the institution.
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Levobunolol (trade names AKBeta, Betagan, Vistagan, among others) is a non-selective beta blocker. It is used topically in the form of eye drops to manage ocular hypertension (high pressure in the eye) and open-angle glaucoma.
Like other beta blockers, levobunolol is contraindicated in patients with airway diseases such as asthma and severe chronic obstructive pulmonary disease (COPD), as well as heart problems such as sinus bradycardia, second- or third-degree atrioventricular block, sick sinus syndrome, and cardiogenic shock. Combination with MAO-A inhibitors is also contraindicated because it could cause a dangerous rise in blood pressure.
Levobunolol is not useful for the treatment of closed-angle glaucoma.
The most common side effect is eye irritation felt as stinging or burning, which occurs in up to a third of patients. Blepharoconjunctivitis occurs in up to 5% of patients. Rarer adverse effects include keratitis, edema and increased lacrimation. Allergies are rare, but seem to be more common than under the related drug timolol.
If the substance reaches the nasal mucosa via the tear duct, it can be absorbed into the bloodstream and cause systemic side effects. These include orthostatic hypotension (low blood pressure) and other effects on the heart and circulatory system, breathing problems in people with asthma, and skin symptoms such as itching and aggravation of psoriasis.
Even in the form of eye drops, levebunolol may cause hypotension when combined with alpha blockers, calcium channel blockers, tricyclic antidepressants, and other drugs that lower blood pressure. It can also cause severe hypertension (high blood pressure) when combined with sympathomimetic drugs or MAO-A inhibitors, bradycardia (low heart rate) when combined with antiarrhythmics or mefloquine, and hypoglycemia (low blood sugar) when combined with antidiabetic drugs such as insulin.
Levobunolol is a non-cardioselective beta blocker, that is, it blocks beta-1 receptors as well as beta-2 receptors. The latter type dominates in the ciliary body, where it controls aqueous humour production. Blocking this type of receptor reduces aqueous humour production, lowering intraocular pressure. The substance has no relevant membrane stabilizing effect or intrinsic sympathomimetic activity. Like other beta blockers, and unlike the anti-glaucoma medication pilocarpine, levobunolol has no effect on accommodation and pupil size.
The substance quickly penetrates the cornea and reaches the aqueous humour. It is reduced to dihydrolevobunolol, which is equally active, in the eye's tissues. The drug starts to lower intraocular pressure within an hour, reaches its maximum effect after two to six hours, and remains effective for up to 16 hours. It has an elimination half-life of six hours and is mainly excreted via the kidney.
Levobunolol is the pure L-enantiomer of bunolol and has more than 60 times the pharmacological activity of D-bunolol. It is used as the hydrochloride, which melts at 209 to 211 °C (408 to 412 °F) and is soluble in water and methanol and slightly soluble in ethanol.
^ a b c d e f g h i Dinnendahl, V; Fricke, U, eds. (2011). Arzneistoff-Profile (in German). 6 (25 ed.). Eschborn, Germany: Govi Pharmazeutischer Verlag. ISBN 978-3-7741-9846-3.
^ a b c d e f Haberfeld, H (ed.). Austria-Codex (in German). Vienna: Österreichischer Apothekerverlag.
^ a b FDA Professional Drug Information on levobunolol.
^ Mutschler, Ernst (2012). Arzneimittelwirkungen (in German) (10 ed.). Stuttgart: Wissenschaftliche Verlagsgesellschaft. p. 781. ISBN 978-3-8047-2898-1.
Ishibashi T, Yokoi N, Kinoshita S (2003). "Comparison of the effects of topical levobunolol and timolol solution on the human ocular surface". Cornea. 22 (8): 709–15. doi:10.1097/00003226-200311000-00001. PMID 14576520.
Ogasawara H, Yoshida A, Fujio N, Konno S, Ishiko S (1999). "[Effect of topical levobunolol on retinal, optic nerve head, and choroidal circulation in normal volunteers]". Nippon Ganka Gakkai Zasshi. 103 (7): 544–50. PMID 10443129.
Leung M, Grunwald J (1997). "Short-term effects of topical levobunolol on the human retinal circulation". Eye. 11 (3): 371–6. doi:10.1038/eye.1997.78. PMID 9373479.
This page was last edited on 1 March 2019, at 22:43 (UTC).


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package org.hibernate.metamodel.source.binder;

import org.hibernate.metamodel.relational.Datatype;
import org.hibernate.metamodel.relational.Size;

/**
 * Contract for source information pertaining to a column definition.
 *
 * @author Steve Ebersole
 */
public interface ColumnSource extends RelationalValueSource {
	/**
	 * Obtain the name of the column.
	 *
	 * @return The name of the column.  Can be {@code null}, in which case a naming strategy is applied.
	 */
	public String getName();

	/**
	 * A SQL fragment to apply to the column value on read.
	 *
	 * @return The SQL read fragment
	 */
	public String getReadFragment();

	/**
	 * A SQL fragment to apply to the column value on write.
	 *
	 * @return The SQL write fragment
	 */
	public String getWriteFragment();

	/**
	 * Is this column nullable?
	 *
	 * @return {@code true} indicates it is nullable; {@code false} non-nullable.
	 */
	public boolean isNullable();

	/**
	 * Obtain a specified default value for the column
	 *
	 * @return THe column default
	 */
	public String getDefaultValue();

	/**
	 * Obtain the free-hand definition of the column's type.
	 *
	 * @return The free-hand column type
	 */
	public String getSqlType();

	/**
	 * The deduced (and dialect convertible) type for this column
	 *
	 * @return The column's SQL data type.
	 */
	public Datatype getDatatype();

	/**
	 * Obtain the specified column size.
	 *
	 * @return The column size.
	 */
	public Size getSize();

	/**
	 * Is this column unique?
	 *
	 * @return {@code true} indicates it is unique; {@code false} non-unique.
	 */
	public boolean isUnique();

	/**
	 * Obtain the specified check constraint condition
	 *
	 * @return Check constraint condition
	 */
	public String getCheckCondition();

	/**
	 * Obtain the specified SQL comment
	 *
	 * @return SQL comment
	 */
	public String getComment();

	public boolean isIncludedInInsert();

	public boolean isIncludedInUpdate();
}

redpajama_set_name: RedPajamaGithub


A few days ago, I was on Facebook following a thread concerning appropriate reading material, in particular YA fiction. If any of you have read any YA lately, sometimes it reads more like adult fiction--very adult fiction.
If that YA novel you picked up is for a younger family member, say a son or a daughter, you may be giving them more of an education than you thought. This is one of the reasons I'm a big proponent of reading what my kids read (but that's another blog post for another time).
Although I check reviews for my reading choices, I also use them for my youngest daughter. She loves graphic novels, but some of them have sexual situations, graphic violence, and other questionable content I know she's not ready for.
Because I usually buy books for Easter instead of candy (although a few jelly beans and chocolate bunnies may find their way into the baskets!), Goodreads and Amazon reviews have proven invaluable when I'm making my purchases.
What about you? Do you use them? How do they help you? Or do you use a different method/site when choosing your reading material?
Goodreads reviews are definitely one place I go to check out book reviews. It's a great place to get a feel for what the reading experience of a book might be like. I also like to check out Common Sense Media for a breakdown of conent like language, violence, and adult situations. They cover movies, books, games, and apps.
Ooh, I've never heard of Common Sense Media. I'll have to look them up since I'm always wondering about that kind of stuff regarding my girls. Thanks for mentioning it!
I look at amazon reviews. Often though, I just read that others I trust recommend or books from respected Christian publishers.
Thanks for the reminder! Word of mouth recommendations are a great resource, Elizabeth, especially from Christian publishers. I've found some good books that way.
Great post, Jill! I don't read a lot of reviews these days, mostly because my author friends are publishing so many books I'm hardly reading anything else! But I can definitely see reviews being important once my kids grow out of children's books!


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LONG ISLAND TEACHER ACCUSED OF SEXUALLY ASSAULTING 10-YEAR-OLD GIRL
Home / General / CHILD SEXUAL ABUSE PREVENTION / LONG ISLAND TEACHER ACCUSED OF SEXUALLY ASSAULTING 10-YEAR-OLD GIRL
Suzanne Amarillo February 1, 2019 CHILD SEXUAL ABUSE PREVENTION, GOOD POLICING CATCHES SEX OFFENDERS AND OTHERS, SEX OFFENDERS AND OTHERS APPREHENDED, SHAME ON YOU, UNBELIEVABLE UNFORGETTABLE, WORST OF THE WORST
Sex Offender and Other Apprehended, Unbelievable, Worst of the Worst, Shame on You, Child Sexual Abuse, Good Policing Catches Sex Offenders and Others
Eyewitness News
HEMPSTEAD, Long Island (WABC) --A Long Island elementary school art teacher is under arrest, accused of sexually abusing a young girl. And police fear there may be more victims. Authorities say 51-year-old John Joseph Finnegan, of Island Park, subjected a 10-year-old girl to inappropriate behavior and sexual contact during an after-school program.
The alleged incident happened January 3 at Jackson Annex Elementary School in Hempstead, where Finnegan teaches. The specifics of the case are not clear, but during the course of their investigation, authorities learned of two additional cases involving two more alleged victims who they believe were targeted by Finnegan during after-school programs.
Finnegan, a teacher in the district for 23 years, has been arrested and is charged with sexual abuse and three counts of endangering the welfare of a child. He was arraigned and ordered held on $20,000 bail. His attorney denied the allegations, calling them "preposterous."
https://abc7ny.com/police-teacher-sexually-assaulted-girl-10-on-long-island/5105902/
BRIGHTON WOMAN GETS JAIL SENTENCE IN SEXUAL ASSAULT OF TEEN
14 N.J. SEX OFFENDERS CHARGED WITH FAILING TO REGISTER NEW ADDRESSES


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Hanetsi, Sun Queen of Metsheput, sat upon her gilded throne, her head held erect. Six burly bearers carried her throne palanquin aloft, though now they stood still, allowing for her to survey the scene before her. Around her stood tall, ebon skinned men, each in burnished silver scale coats, with chain neckguards hanging from their spiked helms, and with spears and broad shields at hand.


Update November 2018: Click here for the brand new 5 for $5.95 Hash Brown Cheeseburger Super Stunner!
Hungry Jack's have launched a brand new edition of their Super Stunner meal to their menu – the Super Stunner!
Recently launched in SA is the new 6 for $6 Super Stunner, as well as the Brekky Super Stunner nationwide.
You can upgrade to a medium meal for $0.70 extra and a large meal for $1.40 extra. You can also switch the Drumstick mini to a Sundae for no extra charge, or a Storm for 50c extra.
Today purchased stunner meal received no sauce or mini drumstick – advised none? Usually a great store with friendly team ?off day?
Hi recently purchased 2 super stunner meals from Echuca store to be conned into cheeseburgers rather than junior whopper burgers. We thought this was wrong but as we were traveling and not from this area didn't go back to complain. upset.


Located 45 minutes from Portland and just 25 minutes from Hood River, here you'll find plenty of space for the wedding party for the big day.
When you book your event with Gorge-ous Weddings, our rustic cabins are included in the wedding package. Tucked away at the edge of the woods, each cabin sleeps up to 5 people and are a short walk to the ceremony and reception sites.


■October 24th thu.19:30-21:00 For Adults.
ESCOE is the embodiment of music and rhythm and has had the privilege of being around and a part of some of the most influential groups in the hip-hop community. ESCOE has been a member of Medea Sirkas aka Demons of the Mind, since 2006. They have been around since 1976 and pioneered styles such as Boogaloo, RoBoting, Struttin', and the Fillmore style. Working in television as a dancer and choreographer as well as live shows/concerts has given ESCOE insight to performance on many levels. He has taught and performed all over the world (London, China, Korea, Abu Dhabi, Hong Kong, Mexico, and U.S.). Teaching private classes up to large dance conventions, he wants to teach anyone who wants to learn. In the last couple years, his goal has been to spread the knowledge and legacy of his friends and people that influence or inspired him while also focusing on his music career.
ESCOE is also a recording artist and music producer. He studied music in school and is fluent in all genres and firmly believes that understanding music and rhythm is crucial for a dancer to be able to reach a high level. He plays 7 instruments, sings, raps, produces, and writes. From making the music to choreographing and getting it to the stage, ESCOE's knowledge is diverse and gives him a unique outlook on dance and teaching as well.
As a solo music artist, ESCOE just had his first couple of major shows selling out a concert with Avicii as well as his own shows. He also had the opportunity to open for Cee lo (Gnarls Barkley) and Goodie Mob and performed at the Rugby 7's in Hong Kong for thousands. He and his team will be launching his career publicly this fall.
ESCOE will be teaching workshops and classes at TRON. The classes will explore rhythm training in different styles of street dance including, popping and all styles in the popping family (waving, boogaloo, animation, fillmore, etc), hip hop, choreography, footwork, stepping, and more. They will be a fun, eclectic, music filled exploration of movement, music, and the body. Good for all ages and all levels.
I love seeing people enjoy the life of music and dance. I think it's important that we continue teaching and inspiring all ages.


Teachers have access to complete, real-time information on student progress through the Teacher Portal. Teachers may access their daily schedules and related lesson materials, along with a variety of resources that enable them to supplement, reinforce, and advance in-class learning.
When teachers log into the Portal, they see their own customized dashboard that includes their daily schedules, calendar, and current groups.
Teachers access Session Planning pages to help prepare them for a lesson they will soon be teaching.
Teachers can also access a primer that includes a clear description of each skill, sample assessment questions, and instructional tips.
The Scoring page provides teachers with the ability to easily take attendance, grade homework, and assign a score for students' work ethic and classroom contribution for that session. Scores help teachers give real-time feedback to students on their overall performance. Scores from the Portal are then synced to a grading platform that enables teachers to produce individual student grades.
The Results page provides teachers with an overview of students' results on the daily Exit Slip for that session. Students can receive a score of Perfect, Good, Almost There, or Room for Growth.
Students and parents also have access to real-time information on student progress through the Student Portal. Students may access their daily schedules, homework, and a variety of resources that enable them to supplement, reinforce, and advance in-class learning. When students log into the Portal they see their own customized dashboard where progress is measured and celebrated with points and badges.


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Dutchess Community College hosts 2020…
Dutchess Community College hosts 2020 graduation online on May 14
File photo by Tony Adamis
By Daily Freeman | news@freemanonline.com and Daily Freeman |
PUBLISHED: May 12, 2020 at 2:03 p.m. | UPDATED: July 21, 2021 at 5:28 a.m.
POUGHKEEPSIE, N.Y., – Dutchess Community College will celebrate the class of 2020 graduation at noon May 14 with a video posted on its website, sunydutchess.edu/graduation and on its social media platforms.
The video will feature submitted photos of graduating students and congratulatory remarks from college President Pamela Edington, Dutchess Community College Board of Trustees Chairman Michael Dupree, Dutchess County Executive Marcus Molinaro ('01) and others
Associate degrees and career certificates in 46 programs of study were earned by 1,006 graduates, who range in age from 18 to 71 years old.
Associate in Science degrees were awarded to 65 percent of the students; 12 percent received Associate in Arts degrees; 20 percent received Associate in Applied Science degrees, and three percent earned certificates.
Additionally, the second cohort of Think Ahead program graduates earned certificates of completion. Think Ahead is a partnership between the College, the county, Abilities First, Maplebrook School, the Arc of Dutchess and Taconic Resources, which teaches life- and job-readiness skills to students with intellectual and developmental disabilities.
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IT WILL not be lost upon Adam Reach that his three picture-book strikes in successive home games have not yielded any wins for Sheffield Wednesday.
Reach's latest effort proved mere consolation for the Owls, who lost out 2-1 to former club Middlesbrough on Friday evening – following on from home draws with West Brom and Leeds United.
Admirably, Reach remains a glass-is-half-full type and is looking at the wider picture of Wednesday's improved form over the past two months ahead of away fixtures at QPR and Birmingham City.
On the task for the Owls, who have won three of their last four games on the road, he said: "After a negative result, I think we have always reacted immediately afterwards which shows good team spirit and strong character from the players.
"We were all disappointed after Boro, but we will go again and concentrate on QPR. If we go there and play like we have done in recent away games, I think we will come away with a result.
It is important to get that monkey off our back. It will come and we are all working hard for that.
One pertinent issue remains the club's inability to keep a clean sheet, which extends back to April 28 – and is something that everyone at Hillsborough is acutely aware of.
Reach added: "Cam (Cameron Dawson) and the defenders are not feeling the pressure because when you keep a clean sheet it is down to the whole team.
Boro, meanwhile, head into tomorrow's home game with Rotherham United in good order after three points at Wednesday, which followed previous away draws at fellow Yorkshire sides Leeds United and Hull City.
Friday was the prelude to a good weekend for the Teessiders, who retained top spot, courtesy of results elsewhere.


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Full of Old City enthusiasm, Yaron has eye on expanding
By MPN RealtyAugust 15, 2005August 26th, 2019No Comments
PHILADELPHIA — Yaron Properties is expanding its presence in Old City by adding two additional residential projects, switching its successful Merchants' Row apartment complex into condominiums, and breaking out a new concept for the building that housed MTV's "Real World" cast.
Yaron has already amassed 10 buildings in Old City and invested more than $100 million in redeveloping the properties into mostly residential structures. Many of the properties have a mix of retail and residential components. It's a section of Philadelphia the developer has focused on since taking a stake in the neighborhood eight years ago.
"There is something about Old City that I find very charming," said Michael Yaron, owner and principal of Yaron Properties.
Yaron isn't the only developer keen on Old City. Historic Landmarks for Living led the way in the mid-1980s, buying historic properties in the neighborhood and redeveloping them into apartments.
Developer interest in the neighborhood continued to rev up in the 1990s as restaurants and trendy lounges came on the scene. Additional apartments and condos were made available in the neighborhood as part of an overall residential boom under way in Philadelphia that has been spurred by tax abatements on conversions and new construction, as well as historically low interest rates.
"Everything people are building is selling, and the process keeps going up for the units," said Steve Clofine, an investment broker with Mallin Panchelli Nadel who has sold 40 buildings in Old City to developers. "I think it's still exploding. Everything I list is sold right away and we have seen no stall or sign of things slowing down."
Yaron has positioned himself to continue creating a critical mass in Old City. He plans to keep identifying what he calls "key properties" in the neighborhood that will have an effect on the direction of Old City. His gusto for the neighborhood and desire for more projects comes after he threatened to halt any future ones after what he called a "fiasco" last year when the city's unions picketed the former Merchant Seamen's Center, a building he owns at 3rd and Arch streets where MTV's "Real World" was preparing to shoot the show, because the work site was non-union.
Arcadia Land Development paid Thomas Richter $4 million for 26 acres at Walker Road and Old Eagle Road in Tredyffrin. Arcadia had been taking plans for the site through the approval process since 2010 and a subsequent settlement with the township has the developer building Wayne Glen, a residential community of 91 villas and carriage homes. Arcadia had planned to built upwards of 240,000 square feet of commercial space on an adjacent 10 acres fronting Swedesford Road at Old Eagle, but that isn't proposed at this time. 73,126 square feet May Cabinets Inc. leased 73,126 square feet at Route 55 Industrial Center at 70 Sewell St. in Glassboro, N.J. as a new manufacturing plant, distribution center and headquarters. Michael T. Bown Sr. of Industrial Investments Inc., the landlord, arranged the lease. The industrial center totals 371,326 square feet and with the lease with May Cabinets, it has just 2,911 square feet vacant.
Since the show was taped last year, the building has sat vacant. Yaron plans to restore and renovate the building as a new gallery called FUEL, which stands for Fostering Undergraduate Exposure on Location. It's geared toward showcasing works done by undergraduate design and visual arts students and is scheduled to open next spring.
Also on Yaron's lineup is to change Merchants' Row at 3rd and Arch streets from rental to for-sale units. The building has 19 apartments and two retail outlets. The success of that property and the seemingly insatiable appetite for condo living in Philadelphia has prompted Yaron to go condo with the apartments.
"We know it will go quickly," Yaron predicted. The units, which range from 700 to 1,400 square feet, will be priced to sell for $600 per square foot.
Drawing on the expected sellout of Merchants' Row, Yaron will break ground in the next 60 days on Merchants' Court, which will sit adjacent to Merchants' Row. Yaron anticipates constructing a seven-story building adjacent to Merchants' Row that will have four condos which will be 2,000 square feet each, or a full floor, and a 3,300-square-foot penthouse. While the smaller units will be priced up to $650 per square foot, the penthouse will sell for as high as $800 per square foot. He also plans a high-end retail outlet for the building. Merchants' Court will be completed within nine months.
Plans are less concrete for 218-230 Arch St., which Yaron recently bought. Preliminary plans call for a $60 million, multistory condo building that will have two levels of retail space and parking. The company is meeting with the Philadelphia Historical Commission and the Old City Civic Association to vet the project.
Yaron is also developing plans for the area from 305 Arch St. to 102-110 N. 3rd St., which is at present a parking lot. It is expected that Yaron will construct a garage on the site but has yet to finalize the plans.


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Q: Address custom enum values by order Usually I can address each item in an enum by it's ordered position (0, 1, 2, 3...), but if I've created an enum with custom values (as below), is there still a way to address each item by its declared order (e.g., Off = 0, _5m = 1, _15m = 2, etc.), rather than its value?
enum WaitTime { Off = 0, _5m = 5, _15m = 15, _30m = 30, _1h = 60, _2h = 120, _3h = 180, _6h = 360, _12h = 720, _1d = 1440, _2d = 2880 }

A: In C# You can use Enum.GetValues() method.

It retrieves an array of the values of the constants in a specified
  enumeration. The elements of the array are sorted by the binary values
  of the enumeration constants.

Array enumElementsInArray = Enum.GetValues(typeof(WaitTime));

int firstElement = enumElementsInArray[0];
int secondElement = enumElementsInArray[1];

But know that, it will return the aray after sorting elements by their values. But of course, for your enum it will work as you want.

A: This would be a generic way that works for all types of enums:
public static T GetValueAt<T>(int idx)
{
  var vals = Enum.GetValues(typeof(T));
  return (T)vals.GetValue(idx);
}

Usage:
var value = GetValueAt<WaitTime>(2); //returns _15m

A: (Answer for C#)
No you wont, e.g. _5m converts to 5, not to 1.
What you call "order" is an implicit conversion to an integer (which by default is 0 ... N-1 for an enum with N values)
enum WaitTime { Off = 0, _5m = 5, _15m = 15, _30m = 30, _1h = 60, _2h = 120, _3h = 180, _6h = 360, _12h = 720, _1d = 1440, _2d = 2880 }

class Program
{
    static void Main()
    {
        WaitTime wt = WaitTime._15m;
        Console.WriteLine((int)wt);
    }
}

Will output 15.
PS.: avoid leading underscores when declaring your enum values.

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UNDP to collaborate with OSSAP to integrate SDGs into state programmes
The Office of the Senior Special Assistant to the President on Sustainable Development Goals (OSSAP-SDGs) is collaborating with the UN Development Programme (UNDP) to integrate SDGs into states policies and programmes.
The office and UNDP on Monday in Abuja, began a three-day workshop tagged 'Advocacy and Capacity Building Workshop on Mainstreaming at the Sub-national level in Nigeria' to train officials on how to integrate state programmes with SDG vision 2030.
Speaking at the event, SSAP-SDGs, Mrs Adejoke Orelope-Adefulire, said the workshop was a conscious attempt at supporting the state governments to prioritise and mainstream the SDGs I to their policies and plans.
"The year 2021 is a landmark year for us, as we commence the Second Phase of scaling-up implementations in the Decade of Action for global goals.
"This will involve strengthening the capacities of state officials to conceptualise, integrate and implement the SDGs at the Sub-national level with the aim of ensuring that no Nigerian is left behind.
"Going forward, we will judiciously use our scarce resources towards programme support as against funding stand-alone projects.
"Due to the proximity of the sub-national governments to the citizens, you have better understanding of their specific needs, and are better able to identify planning gaps as well as facilitate awareness of the SDGs," she said.
Orelope-Adefulire said the officials were expected, at the end of the workshop, to implement SDGs in communities by conducting needs assessments to define priorities, engaging in cooperative governance to establish shared priorities.
She said it would be achieved by aligning local and regional plans with SDGs, mobilising local resources, building capacities for effective and responsive leadership and promoting ownership and sustainability.
Mr Edward Kallon, UN Resident Humanitarian Coordinator in Nigeria, said the COVID-19 had made the achievement of the SDGs more imperative.
He said the situation called for urgency in approach and innovations to find creative ways to accelerate the implementation of SDGs within the remaining time frame.
According to him, for the achievement of the Agenda 2030, it is important to create awareness and sensitise all stakeholders not only at the national level but down to the Sub-national level, to ensure everyone is on board.
On his part , Mr Yemi Kale, the Statistician-General, represented by Director, Corporate Planning and Technical Unit, National Bureau of Statistics, Mr Simon Harry, said various levels must ensure that appropriate allocations were made to implement the SDGs.
Kale said stakeholders also had to look at mechanisms like the national integrating finance framework as an instrument for mobilising required resources.
Mr Amarakoon Bandara, Senior Advisor, UNDP, said the SDGs could not be implemented without implementing them at state level hence the sensitisation of official of the state to familiarise and equip them with the core issues of the SDGs.
The News Agency of Nigeria (NAN) reports that seven states, Lagos, Akwa Ibom, Zamfara, Plateau, Ondo, Kogi and Kwara States are represented at the workshop. (NAN)
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Rheumatoid arthritis (RA) is a representative autoimmune disease characterized by chronic and destructive inflammatory synovitis. The multiple cytokinesand cell surface molecules play a pivotal role in the pathogenesis of RA and binding of these molecules to their ligands on the cell surfaceinduce various signal intracellular transduction including phosphorylation of kinase proteins. The tyrosine kinase is the first intracellular signals to be phosphorylated and 14 tyrosine kinases are known to be involved in RA. Among them, members of Janus kinase (Jak) familyare essential for the signaling pathways of various cytokines and are implicated in the pathogenesis of RA. An orally available Jak3 inhibitor tofacitinib is currently in clinical trials for RA with satisfactory effects and acceptable safety [1, 2]. A phase 2 double-blinded study wascarried out to investigate the efficacy and safety of tofacitinib in Japanese patients with active RA andinadequate responseto methotrexate (MTX). A total of 140 patients were randomized to tofacitinib 1, 3, 5, 10 mg, or placebotwice daily and ACR20 response rates at week 12, a primary endpoint, was significant for all tofacitinib treatment groups . Thus, tofacitinib in combination with MTX was efficacious and had a manageable safety profile and tofacitinib 5 and 10 mg twice a day appear suitable for further evaluation to optimize their potential for the treatment of RA. Although the mode of action of tofacitinib has remain unclear, we clarified thatthe inhibitory effects of tofacitinib could be mediated through the suppression of IL-17 and IFN-γ production and proliferation of CD4+ T cells, presumably Th1 and Th17 cells by in vitro experiments. We next conducted a treatment study in the SCID-HuRAg mice, an RA animal model utilizing SCID mice implanted with synovium and cartilage from patients with RA and tofacitinib was administered via an osmotic mini-pump. Tofacitinib decreased serum levels of human IL-6 and IL-8 in the mice and reduced invasion of the synovial tissue into the implanted cartilage as well as accumulation of immune cells in the synovium.Taken together, orally available low molecular weight products such as tofacitinib targeting intracellular signaling molecules, would provide enormous power and flexibility in the treatment of RA.


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Bolivia salt flats: what's all the fuss about Uyuni?
The Bolivian salt flats and one of the top reasons I wanted to travel in South America in the first place. But when I got there, I hated every second I spent in that salt-drenched desert.
What are the Bolivia salt flats?
The Bolivian salt flats are located just outside of Uyuni and is one of the most travelled to attractions in Bolivia. Instagram is full of salt flat perspective shots and there is a lot of hype around it. And I was excited. At this point in the South America backpacking trip, I had broken up with my boyfriend, spent almost all of money and gotten incredibly sick from a dodgy hot dog in La Paz. But this - this, I told myself - was going to make the toil and turmoil of the trip all worth it.
The journey to the salt flats
From a logistical standpoint To get there, we took a bus and arrived in Uyuni several hours later. Nothing was open and it was hard to get a room. It was a Sunday so also couldn't book the tour. There was nothing left to do but make a very ridiculously makeshift meal in our four-bed dorm room and drink red wine. It was freezing.
Our travel group had become fractured. The next morning we all - still travelling together - walked through the run-down town of Uyuni. It was freezing. The tour person said it was super expensive (find out prices) for the weekend one, so, already freezing our arses off, we wanted to do the one day tour. The ex was disgruntled. He went off to a bar and found some travel buddies. Several beers later and he had agreed to join them on the three-day tour. We bid farewell that night.
All a matter of perspective
We got over it. As a three, we looked forward to our day trip. We jumped in the jeep and went out. Walked around. Took a few photos.
t's everyone's favourite thing to do in Bolivia: take perspective shots on the salt plains. But seriously, that is ALL there is to do. When I bemoaned this, I was met with such travel snobbery it was outrageous. And that is the kind of traveller I think Bolivia attracts (see my in-depth rantings of my dislike for Bolivia backpackers).
It was all quite underwhelming. Granted in hindsight I can almost certainly deduce that the breaking up of the group had something to do with the lack of fun in the salt flats... but I mean, there was nothing there. Tell me how long you think you could stand in freezing cold temperatures with the wind whipping your face, gazing at miles of salty hexagons? For me, it was 45 minutes.
We had a drink and the food flew off the plate.
Dropped us back off, and we went to a restaurant. The unfriendly atmosphere, terrible food. Went to our separate rooms, and I literally froze my arse off until the time came to get our bus. It was one of the single most miserable experiences in my life. Food poisoning the way back, and Brogan is just out of this world gross sick.
When we caught up with the missing member of our South America travel party, he told us about his 2-night, 3-day trip to the salt flats. It was eventful. One of the cars flipped, badly injuring one of the tour guests. They eventually continued on the journey, but the cold killed any kind of magical vibe he had imagined.
There are plenty of people who have the magical time, but this time, it wasn't me.
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