This trip is not for everyone. It wont be a first time exploration trip; but, that is the way it feels every single time. This is an expedition trip into virgin jungle which includes at sometimes making your way as you go.
The highlight of this hike is to reach Los Monos waterfall. Refer to the picture below.
But there is much more ! We will encounter huge trees , dense jungle, crystal clear rivers (if it does not rain) and for sure, now than I mention it, rain. This is the rainiest area of Panama !
Portobelo National Park conserves rivers and mountains in an incredibly virgin state. In it is the Sierra Llorona Mountain Range, in which we enter, and in which it rains an average of 286 days per year.
The topography of the park is very complicated. Its highest point is Cerro Bruja, with 979 meters of altitude, located in the continental watershed. The Pan de Azúcar and Palmas hills and a narrow mountain range within the northern limit of the Panama Canal basin.
It protects the headwaters and watersheds of the region's most important rivers such as Cascajal, Guanche, Piedras, Iguana, Iguanita and Brazuelo.
Our objective is to walk through the jungle until we reach the Salto de los Monos, one of the highest waterfalls in the country and the highest in the Province of Colon, 74 meters high.
We will meet you at your hotel lobby wiithin Panama City at 6:00am to travel toward Colón and arrive to Guanche river mouth by 8:00am. We will stop for breakfast somewhere along the way.
We should be starting to hike around 9:00 top. It should be a 4-5 hour hike from information I had searched on the web. Do not expect trail, but mostly hiking upstream in a slippery and rocky river shore, and trying to avoid it whenever possible walking at its banks.
We will have a light lunch on the way and set up camp not later than 3-4:00pm. If by then we have found Salto de Los Monos we will have achieved our goal.
Next day we should be heading out of the camp by 8:00am after breakfast to trace back to our start up place the day before. We should be back to the car by 3:00-4:00pm at the latest and back to the city around 6:00pm.
WHAT DOES IT INCLUDE ? All mentioned transportation, expedition kayaks and snorkel gear, guides, tents, sleeping pads, camping gear, and meals. Our guides are trained in kayak navigation skills, first-aid and CPR.
WHO CAN GO ? Any person from twelve to seventy years old, in good health. Minors must travel with a responsible adult.
WHAT SHOULD YOU TAKE ALONG ? A pair of shorts for navigating, sneakers or strapped sandals, a cap, sun-block, a light jacket or windbreaker (in case of rain), a blanket, a towel and a dry set of clothes for the trip back.
It's very important to pack only what you will require and use. Also, make sure you pack it so that it'll stay dry, including your sleeping clothes and blanket.
WHAT SHOULD NOT BE BROUGHT ? Any object than can be deteriorated by water or valuables like jewels, cash, credit cards, etc. Anything that you wont use such as extra clothing, make up, etc.
Year around. The rainy season in Panama starts in April-May and ends by November-December. The peak of the rainy season is usually in October.
Flooded river and creeks , if not possible possible at all to cross them, my delay our itinerary or change our plans. We do no fight nature.
This is a remote location with out access roads. Jungle is so dense that an helicopter evacuation might not be feasible. The terrain is very abrupt and slippery. The trail in many sections is poorly marked or totally gone. There are all kind of poisonous plants, insects, and snakes that yes, their bite could kill you. You are totally warned about it.
The group was conformed by Alexandra, Yoselin, Manuel and me.
We met on Saturday, July 30, 2016 at 6:00 am in the offices of Aventuras Panama to distribute in our backpacks group equipment, and then we started our trip to the Guanche River in Colon Province. After a good breakfast and under a persistent rain we started walking at 9:00 am.
We had only hike close to 15 minutes when Manuel, the only participant in the group that had previously done this trip, shared his amazement in front of a raging flood that we had to cross. "Ooops .. there was a bridge before somewhere here ! " We had to managed it swimming to the other shore.
We followed a well-defined path to the mountains along the river. The river was also flooded, and we wondered what we were going to do to go across it. When we arrived at the usual crossing site there was no way to walk to the other side because of current depth and strength. We kept on hiking further upstream until finding a suitable place and again we had to swim. Now, this was not a creek; but, the Guanche River. Manuel swimmed across and them used a rescue cord to safely assist everyone else crossing with their backpacks. Yes, backpacks that were packed for heavy rain; but, not for floods.
By 10:00 am we left behind a cattle farm, and we entered the jungle of the National Park Portobelo. There is a path but not very traveled so it tends to disappear. Thank goodness Manuel was with us !
We moved quickly arriving at 11:00 am at the junction of the Quebrada de Los Monos Waterfall and the Guanche River. The jungle terrain was fairly flat, though with muddy and slippery parts. However, to get to the rivers confluence we had to walk along a rocky slope of the rivershore and due to continuous rain, it was very slippery. Most of our accidents happened here. Although minors memories remains. Alexandra broke her pants beyond any possible repair, and Yoselin experienced a hard landing hurting her legs.
After a rest in which we recover contemplating the landscape we leave the Rio Guanche and follow the river (creek) that will take us to our waterfall.
The terrain became steeper and as we were following a river, to which many ravines joined on it, our path rose and fell abruptly with each crossing of water that defined its course between the mountains. We hiked alternating mud, roots and stones.
At 12:00 m we reached the Solange cascadel where we had lunch after a refreshing, and relaxing shower.
At 2:00 pm we arrived at the camp site. It was so dark that it looked like 6:00 pm and we knew that the persistent rain was going to be replaced by a storm so we set up camp as soon as possible. Yoselin set up his jungle hammock, Alexandra and I set up a tent and we all set up a tent where we made the dining room and kitchen. We look for wood and we set up the typical stove three stones.
It was not long before the downpour was unleashed, just as we had finished putting together the indispensable. Obviously we did not find dry wood anywhere. But after much patience and a couple of old tricks we had our fire burning consistently.
We had a very pleasant time, eating my patented spaghetti recipe with cheese and tuna, drinking wine, chatting and making jokes. As at 9:00 pm we all retired and I doubt that someone took more than 2-3 minutes to fall asleep because of the tiredness we had.
The next day I got up at 7:00 am and Manuel had the fire ready. We had breakfast oatmeal, jam sandwiches with peanut butter accompanied by Tang and instant coffee ... all gourmet cuisine to survive.
After picking up the camp and hiding our backpacks we resumed the trek upstream and in about an hour we had reached our goal ... The Waterfall of Los Monos. No matter how many photos I saw on the internet. I was impressed ! Above all because I did not find any photo that showed the flow that I had at that moment. Unfortunately, by then, my GoPro camera had drowned. Here the sun rose for the first time, opportunely to mock us.
After almost an hour of imagining the photos that we could have taken from all possible angles we started the return which was much faster since we knew the way well and we were lighter.
On our way back we passed our backpacks to the camp site and had lunch at the Solange Waterfall around midday.
We had to improvise a double river crossing in Paso El Jaguar since the shore we used before was under water and this is a place where you do not want to take chances. Here we used river rafting rescue ropes and although it took us very well.
We reach the junction of the rivers around 2:00 pm and we hit the road at 5:30 pm. This time we found a place where the Guanche River split in two and as its level had gone down we could walk through it. The ravine that had received us flooded the first day was low, transparent, and even with bridge.
It was an expedition that surpassed all my expectations. That if, as I warned in the invitation, it is not for everyone. It is for people in very good physical condition, with previous experience in similar activities, who feel comfortable improvising and always seeing the positive side of each situation.
In short, if you enjoy leaving destroyed, hurt, chopped, mottled, cut, tired ... this tour will delight you .... And no, you do not have to be a masochist. You have to have passion for adventure.


text:
For Putin, Syria weapons deal would be masterstroke
Russia backs plan to place Syria%27s chemical stockpile under international control
White House skeptical%2C but plan offers Obama possible path away from confrontation
For Putin%2C it%27s an opportunity to play bigger role in global politics
WASHINGTON — It looks, at least for the moment, like Russian President Vladimir Putin had something useful to contribute to dealing with the Syrian crisis after all.
Weeks after President Obama canceled bilateral meetings in Moscow with Putin because of doubts that anything constructive could come of such a visit, it's the Russians who have offered a potential opening for Obama, who has failed to win support from Americans or Congress to carry out a punitive military strike against the Bashar Assad regime.
Obama told lawmakers Tuesday he has decided to put off a potential strike as he pursues a Russian-backed plan at the United Nations that would place Syria's chemical stockpile under international monitoring.
There is healthy skepticism at the White House about the plan, and administration officials have made clear to the Russians that this can't become a process of delay and avoidance.
But the proposal offers Obama a potential path away from a military confrontation that would allow him to claim Syria paid a price for a chemical attack that killed more than 1,400 people Aug. 21.
The turn in events raises questions about whether the Obama administration properly gauged Putin's motivations and what this could mean for the tense U.S.-Russia relationship.
"It shows that there are still some bargains to be struck with the Russians that the president maybe hadn't taken very seriously," says Stephen Long, a political scientist at the University of Richmond.
In a series of television interviews Monday shortly after the Russians publicly floated their proposal, Obama tried to squash the notion that it came out of thin air.
The president said talk between the United States and Russia about securing the Syrian chemical stockpile dates back to a conversation he had with Putin at a G-20 summit in Los Cabos, Mexico, last year. Obama said he and Putin again discussed the issue on the margins of this year's G-20, which was held last week in St. Petersburg, Russia.
Earlier on Monday, Secretary of State John Kerry had said at a London news conference that a military confrontation could be avoided if Syria gave up its chemical weapons. Later, he spoke by telephone with Russian Foreign Minister Sergey Lavrov and told him the United States was not ready to embrace such a proposal but was willing to take a hard look if it was credible, according to a senior administration official, who spoke on the condition of anonymity to discuss the internal deliberations.
Soon after the Kerry-Lavrov phone call, Lavrov announced that Russia was willing to play a role in securing the Syrian chemical weapons. The proposal was quickly embraced by Syrian government officials and U.N. Secretary-General Ban Ki Moon.
For Putin, the opportunity to reinsert himself into the debate on Syria was ideal.
While Obama has staked his credibility on doing something in Syria, Putin has staked his credibility on not letting Syria become another Libya — a NATO-led and U.N.-sanctioned operation that Putin fiercely opposed and said was tantamount to the Christian Crusades.
"This may be a way for him to look less weak, while also potentially boxing the United States in a corner, if we nonetheless go to war" in Syria, said Matthew Rojansky, a Russian expert at the Wilson Center in Washington.
For the past decade, Russia strove to play a bigger role in global politics, and it's long seen itself as having a rightful place in shaping the Middle East, even though its sphere of influence is largely limited to Syria and Iran.
If Putin is able to help shepherd a deal that averts U.S. military action, it would be a masterstroke. Even if it doesn't head off a strike, he may still end up looking good.
"If it comes to pass, he then becomes a necessary player in Middle East politics – which is something he wants, to enhance Russia's place in determining world affairs," said Michael Corgan, a professor of international relations at Boston University. "If it doesn't happen, then Putin looks like the one who tried to do things peacefully. This is a win-win for him."

redpajama_set_name: RedPajamaCommonCrawl


Patriots Day marks the third time that Peter Berg and Mark Wahlberg have collaborated together, doing Lone Survivor in 2013 and Deepwater Horizon just a few months before the release of Patriots Day. All three of these films address sensitive subjects as they all share the theme of human disaster. Berg's newest film offers a more in depth look into the tragic events that occurred on April 15, 2013 in Boston when two bombs exploded near the finishing line of the famous marathon, taking the lives of three and injuring over 260 innocent citizens. Not even four years later we have our first film adaptation about the incident with a couple more already in development. Tackling a subject like this so soon can be conflicting. For anyone who knows of Peter Berg they would know him for being a proud American who has the utmost respect for all the soldiers fighting for his country. Depending on who makes this film, maybe an Oliver Stone type, this could easily have been looked at as propaganda but Berg tells this story in a more intimate, orderly fashion. Having Boston's boy Mark Wahlberg star and produce the film shows that they truly care about the material and want to make it as genuine a film as possible.
Patriots Day introduces numerous characters early on who all have stories that weave into the events of April 15, 2013. Though some could make the argument that the ensemble is underdeveloped, it's important to realize that this is more than one persons story. Personifying each character gives the audience some backstory into the lives of each character, as we acknowledge them as real people who suffered during the time. The first act does drag at times due to all the changes in perspective but as the film progresses the groundwork that was laid in the first act plays an important part in developing a surreal atmosphere. Towards the end of the second act, into the third is when the tense film becomes flat out spine-tingling as the manhunt in Watertown ensues. Featuring some of his best filmmaking to date, Berg puts us in the middle of the shocking raid that resulted in the city of Boston being on lockdown. Amplified by the haunting score from Trent Reznor and Atticus Ross, the conclusion of Patriots Day is bittersweet and will leave you sniffling and wiping a tear or two away.
Many will debate whether or not this film needed to be made, regardless, Patriots Day is a harrowing but necessary watch as it quickly joins the ranks as one of the most respected American films in recent years. Having this material fall into the hands of Berg and Wahlberg was the best case scenario as they nurtured the delicate subject matter and recognized it with no filter. The cast which features Mark Wahlberg, John Goodman, JK Simmons, Kevin Bacon, and Michelle Monaghan all commit to their roles regardless of its size. With two critically acclaimed films within a few months from each other, Peter Berg has found his stride when it comes to bringing recent historical events to the big screen. Patriots Day works better as a suspense thriller than it does as the traditional docudrama that goes from point A to point B and so on. Never exploitative, the film honors the first responders and pays respect to the victims, while rallying a nation.


Easy bachelorette/bridal shower party decor ideas anyone can do.
I used to see posts with people appreciating Teuchi, the owner of Ichiraku Ramen and I would think it's people being overly dramatic over such a side character in Naruto. Only now with the new theme ending in season 20 am I comprehending how completely amazing he was!
He was probably one of the first people who was actually compassionate towards Naruto. Naruto, whose childhood is heart breaking. An orphan who never knew his parents and was shunned by the village people because of the Nine Tails power inside him. The people of Konaha had lost many loved ones to the Nine Tails rampage and had associated the pain, fear and anger to Naruto, the child who merely carried the Nine Tails.
People would give him a wide berth on the streets, teach their kids not to talk or play or with him, chase him out of their shops and as if that wasn't enough they would glare at him, sneer, call him a monster. The kid faced all this since he was born. Imagine it, a three year old, a four year old, running into a park to play with the other kids only to have their parents whisk them away. To see families walking around, mothers and fathers treating their kids, worrying about them, carrying them on their shoulders or swinging from their arms and all he could do was look on and wonder why he didn't have parents. Naruto grew up confused and lonely, yearning for people to see him, acknowledge him, to be his friends.
When you watch the closing clip and see young three year old Naruto peeking into Ichiraku from behind the wall and jumping up in fear when Teuchi spots him, it breaks your heart. To see such fear in his eyes because he's so used to being shunned haunts you. No child should be made to feel like that. An outsider to the world with no claims to love and compassion from people.
Teuchi invited Naruto inside and gave him a bowl of hot ramen. It became the first place Naruto could go to and feel welcome. A place where people smiled at him, greeted him when he came in. Teuchi would often treat Naruto to free meals on special occasions, share his sorrows and success, ask him about his day.
People like this are the unsung heroes in this world. Their kindness is truly something to aspire to. He gave Naruto the love every kid deserves when no one else could care less. I cannot begin to explain how much I admire him. You can see how surprised Naruto is that the ramen is actually for him and then the smile that lights up his face is priceless. Children should always be smiling like that.
We need to be people like Teuchi from Ichiraku Ramen. Who see and help the people who need it most despite the prejudice around us. They're the true warriors, the heroes that don't get enough appreciation for what they do. It doesn't take much. A kind word, a listening ear and some sincerity. Sincerity and love are all that people want, and orphans deserve it the most. You have no idea how it is to live without parents. To think you're all alone in the world. Love isn't confined for family, it's for every one.
Understand people's situation and don't just feel bad for them. Share their pain. Do something, however small. It makes a huge difference.
Been ages since I wrote anything…. been contemplating to start for a week before I actually made it back here.
It's just that my Facebook is getting crowded, Twitter too a bit.
Well my insecurities are growing alarmingly fast. I hate how I don't feel like talking most of the time, but I want to be heard and matter at the same time. I don't want to be boring. I don't want to be an attention freak…I don't want to be the center of attention. I just want to matter, my opinion to matter. Worst part is, I don't think it matters myself how can other people?
I just want to go to a new place and start over. Or I just want to go to a jungle, desert, mountain, lake anywhere and just get lost in nature and see who I actually am. I feel like myself only when I'm alone or think I'm alone, the former being when I'm alone somewhere and the latter when I'm someplace new and no one knows me and I can say and do as I please.
Maybe I'm just a born loner.
I don't even know why I'm writing this here…it's public…but I want to. A bit.
I wonder how people can be so carefree… be quick at making decisions and be sure of themselves.


She can't win! Now this is on the way … streaming across the global network, destination determined and effect certain!
Y o u c a n ' t s t o p m e . . . y o u c a n o n l y h o p e t o c o n t a i n m e!
… and that means I'm gonna torture Michele.
How? With music, of course … and as a first salvo, I've just fired this via email.
Enjoy. I f y o u c a n.
Michele alerts us that Stacy (who did the layout design for Command Post) is moblogging a Buffet shot at this very moment. Go here to see her pics; even better, go here and listen to the show live.
Who … I say, WHO … ever said that dag-blammed Internet was a waste of time, huh? WHO?!?
Went out to the car this morning, read the thermometer and it read … uhhh … 28 degrees? Really??
Hmmm … coulda' sworn spring was around here somewhere. Oh yeah, there it is.
So without Spring out there, I brought it in here … so check out Tulips, on the Photoblog.
With an entry worthy of this page: Peep Jousting.
Anyhow, if you place Peeps in a microwave and set it for one or two minutes, they'll swell up. Actually, any generic marshmallow will do this, but it's much more fun if they're chicken-shaped. To have a Peep Joust, simply stick a toothpick in two Peeps, place them facing each other in a microwave, and fire that sucker up. Soon enough, the two Peeps will swell and one will stab the other one with its toothpick jousting lance. Sounds fun, doesn't it?


text:
Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup
William Bruno, L. Pastorino, Paola Ghiorzo, Virginia Andreotti, Claudia Martinuzzi, Chiara Menin, Lisa Elefanti, Camilla Stagni, Antonella Vecchiato, Monica Rodolfo, Andrea Maurichi, Siranoush Manoukian, Vincenzo De Giorgi, Imma Savarese, Francesca Gensini, L. Borgognoni, Alessandro Testori, Giuseppe Spadola, M. Mandalà, Gian Lorenzo ImbertiP. Savoia, C. Astrua, Anna M aria Ronco, Alessandra Farnetti, Maria Grazia Tibiletti, Maurizio Lombardo, Giuseppe Palmieri, Fabrizio Ayala, Paolo Antonio Ascierto, Giovanni Ghigliotti, M. Muggianu, Francesco Spagnolo, Virginia Picasso, Enrica T eresa Tanda, Paola Queirolo, Giovanna Bianchi Scarrà
A.O.U. San Martino - IST, Istituto Nazionale Ricerca sul Cancro (GENOVA)
Istituto Oncologico Veneto
Istituto Europeo di Oncologia
Istituto Nazionale Tumori Fondazione G. Pascale
BACKGROUND: Multiple primary melanoma (MPM), in concert with a positive family history, is a predictor of cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) germline mutations. A rule regarding the presence of either 2 or 3 or more cancer events (melanoma and pancreatic cancer) in low or high melanoma incidence populations, respectively, has been established to select patients for genetic referral.
OBJECTIVE: We sought to determine the CDKN2A/CDK4/microphthalmia-associated transcription factor mutation rate among Italian patients with MPM to appropriately direct genetic counseling regardless of family history.
METHODS: In all, 587 patients with MPM and an equal number with single primary melanomas and control subjects were consecutively enrolled at the participating centers and tested for CDKN2A, CDK4, and microphthalmia-associated transcription factor.
RESULTS: CDKN2A germline mutations were found in 19% of patients with MPM versus 4.4% of patients with single primary melanoma. In familial MPM cases the mutation rate varied from 36.6% to 58.8%, whereas in sporadic MPM cases it varied from 8.2% to 17.6% in patients with 2 and 3 or more melanomas, respectively. The microphthalmia-associated transcription factor E318K mutation accounted for 3% of MPM cases altogether.
LIMITATIONS: The study was hospital based, not population based. Rare novel susceptibility genes were not tested.
CONCLUSION: Italian patients who developed 2 melanomas, even in situ, should be referred for genetic counseling even in the absence of family history.
Journal of the American Academy of Dermatology
https://doi.org/10.1016/j.jaad.2015.09.053
Published - Feb 1 2016
cyclin-dependent kinase
cyclin-dependent kinase inhibitor 2A
microphthalmia-associated transcription factor
10.1016/j.jaad.2015.09.053
http://www.scopus.com/inward/citedby.url?scp=84973407250&partnerID=8YFLogxK
Dive into the research topics of 'Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup'. Together they form a unique fingerprint.
Multicenter Studies Medicine & Life Sciences 100%
Microphthalmia-Associated Transcription Factor Medicine & Life Sciences 39%
Germ-Line Mutation Medicine & Life Sciences 19%
Genetic Counseling Medicine & Life Sciences 19%
Mutation Rate Medicine & Life Sciences 18%
Cyclin-Dependent Kinase Inhibitor p16 Medicine & Life Sciences 12%
Pancreatic Neoplasms Medicine & Life Sciences 8%
Bruno, W., Pastorino, L., Ghiorzo, P., Andreotti, V., Martinuzzi, C., Menin, C., Elefanti, L., Stagni, C., Vecchiato, A., Rodolfo, M., Maurichi, A., Manoukian, S., De Giorgi, V., Savarese, I., Gensini, F., Borgognoni, L., Testori, A., Spadola, G., Mandalà, M., ... Bianchi Scarrà, G. (2016). Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup. Journal of the American Academy of Dermatology, 74(2), 325-332. https://doi.org/10.1016/j.jaad.2015.09.053
Multiple primary melanomas (MPMs) and criteria for genetic assessment : MultiMEL, a multicenter study of the Italian Melanoma Intergroup. / Bruno, William; Pastorino, L.; Ghiorzo, Paola et al.
In: Journal of the American Academy of Dermatology, Vol. 74, No. 2, 01.02.2016, p. 325-332.
Bruno, W, Pastorino, L, Ghiorzo, P, Andreotti, V, Martinuzzi, C, Menin, C, Elefanti, L, Stagni, C, Vecchiato, A, Rodolfo, M, Maurichi, A, Manoukian, S, De Giorgi, V, Savarese, I, Gensini, F, Borgognoni, L, Testori, A, Spadola, G, Mandalà, M, Imberti, GL, Savoia, P, Astrua, C, Ronco, AMA, Farnetti, A, Tibiletti, MG, Lombardo, M, Palmieri, G, Ayala, F, Ascierto, PA, Ghigliotti, G, Muggianu, M, Spagnolo, F, Picasso, V, Tanda, ETE, Queirolo, P & Bianchi Scarrà, G 2016, 'Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup', Journal of the American Academy of Dermatology, vol. 74, no. 2, pp. 325-332. https://doi.org/10.1016/j.jaad.2015.09.053
Bruno W, Pastorino L, Ghiorzo P, Andreotti V, Martinuzzi C, Menin C et al. Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup. Journal of the American Academy of Dermatology. 2016 Feb 1;74(2):325-332. doi: 10.1016/j.jaad.2015.09.053
Bruno, William ; Pastorino, L. ; Ghiorzo, Paola et al. / Multiple primary melanomas (MPMs) and criteria for genetic assessment : MultiMEL, a multicenter study of the Italian Melanoma Intergroup. In: Journal of the American Academy of Dermatology. 2016 ; Vol. 74, No. 2. pp. 325-332.
@article{df2a3a41e3924077a057333c3d4d59fe,
title = "Multiple primary melanomas (MPMs) and criteria for genetic assessment: MultiMEL, a multicenter study of the Italian Melanoma Intergroup",
abstract = "BACKGROUND: Multiple primary melanoma (MPM), in concert with a positive family history, is a predictor of cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) germline mutations. A rule regarding the presence of either 2 or 3 or more cancer events (melanoma and pancreatic cancer) in low or high melanoma incidence populations, respectively, has been established to select patients for genetic referral.OBJECTIVE: We sought to determine the CDKN2A/CDK4/microphthalmia-associated transcription factor mutation rate among Italian patients with MPM to appropriately direct genetic counseling regardless of family history.METHODS: In all, 587 patients with MPM and an equal number with single primary melanomas and control subjects were consecutively enrolled at the participating centers and tested for CDKN2A, CDK4, and microphthalmia-associated transcription factor.RESULTS: CDKN2A germline mutations were found in 19% of patients with MPM versus 4.4% of patients with single primary melanoma. In familial MPM cases the mutation rate varied from 36.6% to 58.8%, whereas in sporadic MPM cases it varied from 8.2% to 17.6% in patients with 2 and 3 or more melanomas, respectively. The microphthalmia-associated transcription factor E318K mutation accounted for 3% of MPM cases altogether.LIMITATIONS: The study was hospital based, not population based. Rare novel susceptibility genes were not tested.CONCLUSION: Italian patients who developed 2 melanomas, even in situ, should be referred for genetic counseling even in the absence of family history.",
keywords = "cyclin-dependent kinase, cyclin-dependent kinase inhibitor 2A, family history, genetic assessment, melanoma, microphthalmia-associated transcription factor, mutation, pancreatic cancer",
author = "William Bruno and L. Pastorino and Paola Ghiorzo and Virginia Andreotti and Claudia Martinuzzi and Chiara Menin and Lisa Elefanti and Camilla Stagni and Antonella Vecchiato and Monica Rodolfo and Andrea Maurichi and Siranoush Manoukian and {De Giorgi}, Vincenzo and Imma Savarese and Francesca Gensini and L. Borgognoni and Alessandro Testori and Giuseppe Spadola and M. Mandal{\`a} and Imberti, {Gian Lorenzo} and P. Savoia and C. Astrua and Ronco, {Anna M aria} and Alessandra Farnetti and Tibiletti, {Maria Grazia} and Maurizio Lombardo and Giuseppe Palmieri and Fabrizio Ayala and Ascierto, {Paolo Antonio} and Giovanni Ghigliotti and M. Muggianu and Francesco Spagnolo and Virginia Picasso and Tanda, {Enrica T eresa} and Paola Queirolo and {Bianchi Scarr{\`a}}, Giovanna",
doi = "10.1016/j.jaad.2015.09.053",
journal = "Journal of the American Academy of Dermatology",
T1 - Multiple primary melanomas (MPMs) and criteria for genetic assessment
T2 - MultiMEL, a multicenter study of the Italian Melanoma Intergroup
AU - Bruno, William
AU - Pastorino, L.
AU - Ghiorzo, Paola
AU - Andreotti, Virginia
AU - Martinuzzi, Claudia
AU - Menin, Chiara
AU - Elefanti, Lisa
AU - Stagni, Camilla
AU - Vecchiato, Antonella
AU - Rodolfo, Monica
AU - Maurichi, Andrea
AU - Manoukian, Siranoush
AU - De Giorgi, Vincenzo
AU - Savarese, Imma
AU - Gensini, Francesca
AU - Borgognoni, L.
AU - Testori, Alessandro
AU - Spadola, Giuseppe
AU - Mandalà, M.
AU - Imberti, Gian Lorenzo
AU - Savoia, P.
AU - Astrua, C.
AU - Ronco, Anna M aria
AU - Farnetti, Alessandra
AU - Tibiletti, Maria Grazia
AU - Lombardo, Maurizio
AU - Palmieri, Giuseppe
AU - Ayala, Fabrizio
AU - Ascierto, Paolo Antonio
AU - Ghigliotti, Giovanni
AU - Muggianu, M.
AU - Spagnolo, Francesco
AU - Picasso, Virginia
AU - Tanda, Enrica T eresa
AU - Queirolo, Paola
AU - Bianchi Scarrà, Giovanna
N2 - BACKGROUND: Multiple primary melanoma (MPM), in concert with a positive family history, is a predictor of cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) germline mutations. A rule regarding the presence of either 2 or 3 or more cancer events (melanoma and pancreatic cancer) in low or high melanoma incidence populations, respectively, has been established to select patients for genetic referral.OBJECTIVE: We sought to determine the CDKN2A/CDK4/microphthalmia-associated transcription factor mutation rate among Italian patients with MPM to appropriately direct genetic counseling regardless of family history.METHODS: In all, 587 patients with MPM and an equal number with single primary melanomas and control subjects were consecutively enrolled at the participating centers and tested for CDKN2A, CDK4, and microphthalmia-associated transcription factor.RESULTS: CDKN2A germline mutations were found in 19% of patients with MPM versus 4.4% of patients with single primary melanoma. In familial MPM cases the mutation rate varied from 36.6% to 58.8%, whereas in sporadic MPM cases it varied from 8.2% to 17.6% in patients with 2 and 3 or more melanomas, respectively. The microphthalmia-associated transcription factor E318K mutation accounted for 3% of MPM cases altogether.LIMITATIONS: The study was hospital based, not population based. Rare novel susceptibility genes were not tested.CONCLUSION: Italian patients who developed 2 melanomas, even in situ, should be referred for genetic counseling even in the absence of family history.
AB - BACKGROUND: Multiple primary melanoma (MPM), in concert with a positive family history, is a predictor of cyclin-dependent kinase (CDK) inhibitor 2A (CDKN2A) germline mutations. A rule regarding the presence of either 2 or 3 or more cancer events (melanoma and pancreatic cancer) in low or high melanoma incidence populations, respectively, has been established to select patients for genetic referral.OBJECTIVE: We sought to determine the CDKN2A/CDK4/microphthalmia-associated transcription factor mutation rate among Italian patients with MPM to appropriately direct genetic counseling regardless of family history.METHODS: In all, 587 patients with MPM and an equal number with single primary melanomas and control subjects were consecutively enrolled at the participating centers and tested for CDKN2A, CDK4, and microphthalmia-associated transcription factor.RESULTS: CDKN2A germline mutations were found in 19% of patients with MPM versus 4.4% of patients with single primary melanoma. In familial MPM cases the mutation rate varied from 36.6% to 58.8%, whereas in sporadic MPM cases it varied from 8.2% to 17.6% in patients with 2 and 3 or more melanomas, respectively. The microphthalmia-associated transcription factor E318K mutation accounted for 3% of MPM cases altogether.LIMITATIONS: The study was hospital based, not population based. Rare novel susceptibility genes were not tested.CONCLUSION: Italian patients who developed 2 melanomas, even in situ, should be referred for genetic counseling even in the absence of family history.
KW - cyclin-dependent kinase
KW - cyclin-dependent kinase inhibitor 2A
KW - family history
KW - genetic assessment
KW - melanoma
KW - microphthalmia-associated transcription factor
KW - pancreatic cancer
U2 - 10.1016/j.jaad.2015.09.053
DO - 10.1016/j.jaad.2015.09.053
JO - Journal of the American Academy of Dermatology
JF - Journal of the American Academy of Dermatology


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Energy, Industry and Resources
WSP receives Engineering Firm of the Year at SAPSA 2019 Awards
WSP in Africa is proud to have received the Engineering Firm of the Year award at the SA Professional Services Awards (SAPSA) for 2019, as announced during the gala dinner hosted at the Monte Casino Ballroom in Johannesburg, South Africa.
15 March 2019 - South Africa
Designed to celebrate the professional achievements of key individuals and the distinction of professional service firms across various industries, these awards involve strict criteria as well as a rigorous judgement process for determining the winners.
WSP with award for Engineering Firm of the Year
Mathieu du Plooy, Managing Director, accepting the award on behalf of WSP
Mathieu du Plooy, Managing Director, WSP in Africa said: "We are elated and honoured to have received this accolade. In addition to winning the overall category award, we are also exceptionally proud that three engineers from our ranks received individual recognition and commendation – Jabulile Nhlapo and Vishaan Ramnarian in the Young Professional of the Year category and Vishaal Lutchman in the Professional of the Year category."
Individual recognition and commendations
Jabulile Nhlapo and Vishaan Ramnarian for Young Professional of the Year, and Vishaal Lutchman in the Professional of the Year category
"As a firm, we pride ourselves on offering premier consultancy services to public and private sector clients across the built and natural environments – and ensuring we attract and retain top talent. This accolade reinforces market recognition of our unwavering commitment in both regards," added du Plooy.
In a statement issued by SAPSA, Janette Minnaar, the chair of the adjudication panel explained how the winners were determined: "They were judged based on a host of attributes including demonstration of leadership skills, changing of paradigms and innovation within the bounds of available resources. We also conferred a number of Lifetime Achievement Awards to deserving recipients who had served their professions faithfully for many years."
Sponsored by Sanlam, SAPSA aims to recognize the professional excellence of individuals across industries such as accounting, management consulting, architecture, legal, quantity surveying, and engineering. The award groupings are defined into two broad categories, namely; Legal & Finance and Engineering & The Built Environment – and within these there are overall category winners, as well as different awards capturing the levels mentioned below:
Professional Services Firm of the Year award
Professional of the Year Award
Young Professional of the Year Award (aged 35 and younger)
Woman Professional of the Year Award
For more details on the 2019 winners: http://saproawards.co.za
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It's been a few days since I've had a download on offer for something other than U2, so it's great that Indiecater has another stellar new release. This time it's Candy Claws, and their excellent In the Dream of the Sea of Life, an album bound to appeal to lovers of Panda Bear and Animal Collective. I have a preview download below, but on the site you can stream the album in full and then buy it for €4!


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The Ford Mustang Was Almost The Original 'Imported From Detroit' Car: History Alley
Today, the tagline "Imported from Detroit" is virtually inseparable from the Chrysler brand. But interestingly, while performing research for a new book entitled Once in a Great City: A Detroit Story, author David Maraniss discovered that the slogan almost belonged to a very different Detroit original: the 1964 Ford Mustang.
Automotive News reports that in the book, Maraniss describes how ad agency J. Walter Thompson proposed marketing the yet-unnamed Ford Mustang as a "brand new import… from Detroit… inspired by Italy's great road cars, but straight from Detroit." The pony car was originally to be called the "Torino," after the city of Turin, Italy, but that name was instead pocketed until 1968, when it was applied to a different pony car model. The Ford Mustang's original marketing angle, however, was retired altogether.
So why the last-minute switch-up? Maraniss writes that at the time of the original Ford Mustang's product planning, Henry Ford II was undergoing a divorce, and had been linked romantically to Italian woman Cristina Vettore Austin. Ford Motor Company felt that the pony car's original marketing strategy could have added more fuel to the fire, resulting in more bad press for both Henry Ford II, and the automaker.
Ford later married Christina Vettore, and the "Imported from Detroit" tagline was resurrected by Chrysler for an ad campaign beginning in 2011.
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Giorgio Piola and Sutton Images reveal the all-important Formula 1 technical updates on show in the Silverstone pitlane at the British Grand Prix.
Toro Rosso has unveiled a new set of wing mirrors which follow the same design concept as those used by Ferrari since the start of the season. The open-faced mirror housings improve flow around the mirror itself and its surroundings.
Flo-viz is painted on the rear wing endplate of the Sauber as the team establishes whether the large strake added in the middle of the element is performing the task expected of it.
Alonso re-trials the prototype front wing which first appeared in Austrian GP Free Practice. Flo-viz is painted on the wing to help the designers understand if it's performing as expected.
Kiel probe arrays are mounted behind the front wheels on the RB14 during FP1 as the team looks to collect data.
A rear view of the SF71H showing off the spoon-shaped rear wing and tapered engine cover cooling solution.
Stoffel Vandorne testing a prototype front brake duct again, having already given it a run out in Austria.
A Renault mechanic makes an adjustment to the RS18 in the pitlane.
A close-up of the MCL33's front brake duct sprayed with flo-viz paint.
The underside of the prototype front wing mounted on the McLaren MCL33 has been painted in the flo-viz, as seen on the strakes.
The STR13 with a kiel probe array mounted behind the left front wheel to collect data.
Stoffel Vandorne climbs out of his MCL33, of which the halo has been painted with flo-viz paint.
A close-up view of the outboard section of the SF71H's diffuser, which since its update has more than a hint of Red Bull design about it.
A look at Red Bull's turning vanes, note the metal support which bridges the vanes to the bargeboards just behind.
The front wing and left-hand sidepod bodywork removed from the Mercedes W09.
Mercedes added an extra mirror and housing beneath the new mirror and stalks that were introduced in Austria. A thermal-imaging camera is also housed within.
A UV light is used to show up the true effect of the flo-viz that's been painted on the Mercedes W09's front brake duct and suspension.
A rearward shot of the additional mirror mounted on the W09 during Free Practice.
The front wing mounted on Daniel Ricciardo's car has an extreme cutout, creating a curvature in the upper flaps. The Kiel probe arrays mounted behind the front wheels collect data on how the airflow is affected by this change.
As a comparison this is the wing mounted on Max Verstappen's car which features the conventional flap design.
Hamilton: Silverstone's new DRS zone "pointless", "dangerous"


Kazantzakis and Istrati met during the former's trip to the Soviet Union in November 1927. Both were social reform enthousiasts, but their different way of seeing it tore them apart.Kazantzakis was too metaphysical, and Istrati took a materialistic view that his friend couldn't cope with.
A second meeting the following year just widened the gap between them. They continued corresponding, however, and "Don Quixote" was written for Istrati.
Istrati visited Greece shortly after he had met Kazantzakis, to give a lecture on the Bolshevik Revolution, which caused a demonstration in Athens, and resulted in his deportation. During his stay, he visited left-wing patients with tuberculosis in an Athens hospital, being himself a patient, which didn't go down too well with authorities. He died sick and alone in Bucarest.
Kazantzakis outlived him by 22 years. He mentions Istrati repeatedly in his works.
Here is an excerpt chosen and translated by Costas Papageorgiou, to match the photo of the friends in Athens.
"We entered a restaurant, we sat down. He then took a bottle of oil he wore around his neck as a charm and poured it in his food. Afterwards he took a box of pepper out if his vest pocket and threw in his rich meat soup.
-Oil and pepper, he said licking his lips. Just like Braila!
-Welcome! Welcome back. How have you been?
He kept an eye on his watch. All of a sudden he stood up.
He called for the waiter; he took four bottles of fine Armenian wine, filled his coat pockets with small packs of desserts, overfilled his tobacco box with cigarettes and off we went."
Νίκος Καζαντζάκης, Αναφορά στον Γκρέκο.
Should we look at the Romanian folklore, a faithful mirror of the folk mindset, we will note that Romanians had always empathized with the Greeks, considering them friends with whom they shared religion and often the same hardships. A comparative study of mentalities could reveal striking similarities and affinities between the two nations. Greek literary works gained wide recognition on Romanian soil and became popular reading.
Furthermore, mention should be made of the fact that the beginnings of modern Romanian literature are closely intertwined with those of neo-Hellenic literature. The first generation of 19th century poets formed under the influence of the Phanariot Athanasios Hristopoulos. Most Romanian intellectuals in the former half of the 19th century could speak Greek (as alumni of the Princely Academies or of the many Greek private schools) and made their literary debut with translations from Neo-Greek.
The most direct means of dialogue between the two cultures is provided by translations. No wonder therefore that in point of translations from neo-Greek, Romania holds one of the leading positions in Europe. The Romanian public has familiarized with neo-Greek literature through translations since the 17th century.
Daca ne uităm la folclorul românesc, o oglindă fidelă a modului in care se construieste un popor, vom nota că românii au avut întotdeauna relatii faine cu grecii, considerându-i prietenii cu care au împărtăşit atat religia dar de multe ori si greutatile. Un studiu comparativ al mentalităţilor ar putea dezvălui şi afinitati, izbitoare asemănări între cele două naţiuni. operele literare in limba greaca au dobândit o mare recunoaştere si pe teritoriul românesc a devenit o lectură mai mult decat populara.
Mai mult, ar trebui să se menţioneze faptul că începuturile literaturii moderne a românilor sunt strâns legate cu cele din literatura de neo-elena. Prima generaţie de poeţi din secolul 19 s-au format sub influenţa Phanariot Athanasios Hristopoulos. Cei mai mulţi intelectuali români, în fosta jumătate a secolului al 19-lea, puteau vorbi greacă (ca absolventii de la Academiile domnesti sau de la mai multe şcoli private de greacă) şi si-au făcut debutul literar cu traduceri din neo-greacă.
Cel mai direct mijloc de dialog între cele două culturi este furnizat de traduceri. Nu e de mirare, prin urmare, că, în ce priveste numarul de traduceri din neo-greacă, România deţine una din pozitiile de top în Europa.Românii sunt familiarizati cu literatura neo-greacă, prin traduceri, inca din secolul al 17-lea.


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Paterson police officer indicted for allegedly assaulting teen, attempting to cover up attack - about 1 hour ago
Paterson woman arrested in deadly Main Street hit-and-run incident
July 20, 2021 by Jonathan Greene
A city woman has been arrested in connection with a deadly hit-and-run incident on Main Street, according to the Passaic County Prosecutor's Office.
Kymora Jordan, 30-year-old, was arrested on Monday and charged with leaving the scene of a motor vehicle accident resulting in death, endangering an injured victim, and driving while suspended and causing death.
During the early morning hours on April 24, Jordan drove an Audi A4 near 645 Main Street. She struck 44-year-old Armando Medrano of Lodi and left the scene of the accident, authorities said.
Medrano was later pronounced dead.
Jordan could face decades in state prison if convicted on the charges. She is being held at the Passaic County Jail.
That's no she. That's a man. Fact is he will never be able to be pregnant and give birth.
Jadey223
That's your first thought upon finishing this article? Imagine being obsessed with someone else's reproductive organs. Weird.
Paterson Resident
You are one hopeless individual
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Probably under the influence and dirty


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The biggest event of the design year, Milan's Salone Del Mobile festival saw the city once again taken over by the interiors industry. The streets were packed with the biggest names in furniture and architecture, exhibiting alongside up-and-coming names that are new on the scene. Our own in-house design team were out scouring the studios and showrooms for the hottest trends on show, dissecting the wealth of ideas to select six key trends that we are confident will be driving the look of our interiors over the next 18 months and beyond. These diverse trends will be filtering through many aspects of interior design, with the overall drive being towards a warmer, tactile and soothing look and feel for our homes.
Soft, subtle colours – ones that are easy on the eye and the psyche - were in evidence everywhere, suggesting a desire for soothing interior elements as an escape from stressful lives. The core colour was a skin-tone pink, evoking the sense of touch and inviting an emotional connection. We saw this combined with organic, unbleached wood and tactile brass and copper.
Once considered a rather retro, ostentatious material, marble continues its comeback as the luxury accent of choice. This year we saw marble used on everything from chairs to bookcases, with warmer, mottled versions more popular than harsh white. Marble was combined with slick materials like plastic as well as organic, sensual wood and metal, again with warm colour tones to the fore.
Once seen as cold, hard and industrial, metal finishes in warm tones continued to provide an air of luxury and light to many pieces shown this year. Copper, brass and bronze featured in numerous designs across all design disciplines, but the rose gold was the finish of choice, adding glamour when combined with materials like exotic wood, leather and velvet. Star of the show was Knoll's iconic Platner arm chair, created in 18 karat gold and blue velvet to celebrate its 50th anniversary.
At the Eurocucina dedicated kitchen exhibition at Salone the kitchens were hard to find! Many companies displayed kitchens that hid their workings when not in use – cooker hoods that retract into the wall, sliding covers for hobs, and even a worktop insert to cover the sink. In addition, large sliding door sections were used to close off the whole kitchen, turning it into an object of furniture or sculpture. The trend points both to our increased desire for a clear, uncluttered environment, and the need for open-plan living spaces to conceal multiple functions.
Technology and tradition collided to present new ways of working with wood this year. Modern production and processing techniques have created an explosion in fluid, sensual forms for wood furniture, where curved lines and surfaces both highlight the natural grain of the wood and also invite the user to make physical contact with this enduring material. This is enhanced by the combining of wood with other tactile materials like leather and moulded plastic.
Design for children is emerging as one of the hot trends as designers and brands cotton on to the vast potential of the kids' furniture market. Among those to spot a gap in the market was Italian brand Kartell, which launched an entire new range of products for younger users. In most cases brands are approaching the objects as adult's furniture for the reason that you do not have to clutter your house with objects that do not fit into the environment.


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Social Networking with Interactive Promotions~Interactive Promotions and Social Networking~Enhance Interactive Promotions with Social Media
Article by Rex Thompson
Within the past few years, social networking has skyrocketed from a frivolous add-on to an essential part of every interactive marketing campaign~In recent times, social networking has launched into a crucial part of every modern interactive marketing campaign~Marketing campaigns today are increasingly dependent on social networking. With interactive promotions, or the practice of promoting brands and services online, social networking has even become the starting point for marketing brands and launching viral campaigns that are able to reach a bigger audience than TV or paper ads had ever accomplished~In terms of interactive promotions, social networking has provided a launching pad for brands and viral campaigns to reach a larger and more quality audience than other media, such as TV commercials and radio ads~Marketing campaigns can now reach a wider, more relevant audience with social networking integrated into their interactive promotions campaign, which is increasingly more effective than TV or radio ads.
Many companies have taken advantage of the free services offered by Facebook, Twitter, and RSS Feeds to get their brand out to a wider audience, but how many understand the true value of what these social networks are capable of doing and why they make such a huge impact on the rise and fall of a marketing campaign~How many companies truly understand the value of social networking and its ability to increase and decrease profits in a marketing campaign~With so many companies taking full advantage of free services like Facebook and Twitter, is it any wonder than many marketers don't understand the true value of using these? Once marketers begin understanding the precise role of social media platforms, many problems can be solved and overall efficiency of marketing can be improved~When marketers can finally understand the exact role of social media in their campaigns, several problems can be resolved and the efficiency of marketing can ameliorate~Understanding the precise role of social media can increase the efficiency of the entire campaign while solving many other problems in the process.
The first thing to understand is the need to precisely define what social media is~Defining what social media is can be a great place to start~Knowing the exact definition of social media is an ideal place to start. Social media are tools used to share and encourage interaction between users, particularly through social networks devised on Internet platforms such as Twitter and Facebook~Using platforms like Twitter and Facebook, social networks are tools used to share and stimulate interaction between users and the content generators~Strictly speaking, social media is a tool utilized amongst Internet users to share and exchange information of articles, blogs, and status updates amongst online communities. Social media strives to stimulate user-generated content in the form of blogs, comments, status updates, and photos to circulate information amongst various crowds~Various crowds can benefit from the information found on blogs, comments, and status updates that circulate in these social networks~An overarching goal of social media is always striving to encourage user-generated content in various forms, including blogs, comments, status updates and photos.
Marketers love social media, because it appears to do half the work for them~There are many reasons why marketers adore social media, one of them being is it appears to do most of the work for them~Among the several reasons marketers love using social media is because it almost does half of their work for them. In terms of brand exposure and presence, there is almost nothing easier to use, nor as wide-reaching, as social media networks~Nothing is easier to use, nor is anything as far-reaching, as the breadth of social media networks in terms of exposing a brand~When seeking to give brand new exposure and market presence, nothing is easier or as widespread as social media networks. With a few choice words, an eye-catching icon, and a link directing to the brand's website, marketers can update multiple social media platforms with a single keystroke~In a single keystroke, marketers can release new information through multiple social platforms with eye-catching descriptions, icons, and links~Releasing new information from a brand or company can now be published with one keystroke across several platforms that reach thousands in a matter of seconds. Within minutes, users will either respond, "re-tweet", or pass along the information to their friends online~Users are then capable of responding and passing the information along to their online network of friends~The information can them be shared among friends and one's personal network online community. The best case scenario is when the brand's ad or promotional item goes viral, which is when people start sharing it via word of mouth, a golden technique that is highly difficult to attain through traditional media~In the most ideal of scenarios, the brand will go viral and people will begin spreading it through word of mouth, which is the best way to expose a brand~Unlike traditional media, having the brand go viral through the Internet and eventually via word-of-mouth is the best situation that any marketer can ask for.
So what does this mean for the interactive promotions industry~What does this signify for a nascent industry such as interactive promotions~For interactive promotions, what does this mean? It means that another tool has been added to the box~It signifies that an additional tool and resource has been added to the supply closet~It means an additional resource has joined the toolbox. Social media, when done right, accomplishes what marketers have been trying to do for decades: gain an intricate understanding of their audience and the things they like and don't like while creating a direct relationship with the consumer~Marketers have been trying for decades to achieve the goal they've always strived to obtain, which is an intricate understanding of their audience and building a direct relationship with them~Understanding their audience and building a direct relationship with them is what marketers have always strived to obtain in their goals. It builds trust, understanding, and a mutually beneficial agreement that allows the relationship to flow both ways instead of one~Social media builds trust, understanding and an agreeable system of benefits for both parties~Instead of an one-way direction for a marketing relationship to flow, social media has enabled it to become a two-way system where both parties benefit.
When interactive promotions utilize social media platforms, they often end up being for brand exposure and directing traffic to a website where they can purchase items or fill out forms to receive direct consultations on various services~Often times when interactive promotions seek to utilize social media networks, it is typically for brand exposure or to receive direct consultation on a variety of services~Interactive promotions can sometimes use social media platforms for other purposes, such as gathering consumer information for receiving direct consultation in making their next step. Twitter, for instance, has infiltrated every websites by the now-ubiquitous aqua-hued logo on the top fold their site~Nowadays, Twitter has become an ubiquitous symbol on many sites that wish to have a social media presence~By enabling Twitter on a website, it becomes a way for consumers to identify the symbol with the brand. Companies also create Facebook pages where users can receive a discount off purchases or generous freebies via status updates that link quizzes, advergames, and other interactive promotional activities that engage the user~Engaging the user can be accomplished through Facebook pages that constantly offer new deals and discounts, while links to advergames and quizzes can effectively hook new consumers~There are many methods of attracting and keeping consumers, some of which can include utilizing a Facebook page that dishes discounts and deals with links to advergames and quizzes to keep the interactive promotions campaign alive.
Marketers should exercise caution in using social media as a means to itself~Using social media should be used with caution~Marketers should tread on social media with caution, especially when attempting to use it as a means it itself. In reality, it should remain one of various tools used in interactive promotions and not as a way to rack up followers for the sake of coming out on top~In interactive promotions, this should remain one of many tools that effectively attract quality consumers~Social media tools should be used as a part of an interactive promotions campaign rather than a means to ratchet up as many followers as possible. With tactful, well-time messages in social networks, interactive promotions can be increasingly enhanced without becoming overshadowed~When social networks are effectively implement, interactive promotions campaigns can be enhanced by them rather than overshadowed~Social media should never overshadow an interactive promotions campaign, but rather be effectively complementing.
Rex Thompson is a internet marketing and social media enthusiast from Atlanta, GA. In his spare time, he enjoys blogging on the future of interactive promotions and experimenting in the kitchen, especially with sushi.
Tags: Interactive, Media, Networking, Networking~Enhance, Promotions, Promotions~Interactive, Social


This set of Linear Integrated Circuit Multiple Choice Questions & Answers (MCQs) focuses on "Voltage Series Feedback Amplifier – 1".
1. Specify the voltage gain of non-inverting amplifier with feedback amplifier with and without feedback?
Explanation: The voltage gain of op-amp with feedback is the open loop voltage gain, A=Vo /Vid. The voltage gain of op-amp without feedback is the closed loop voltage gain, AF = Vo /Vin.
2. If the feedback voltage and the output voltage are given as 10v and 4v. Find the gain of the feedback circuit in voltage-series feedback amplifier?
Explanation: Gain of feedback, B = Vf /Vo = 10v/4v = 2.5v.
3. How is the difference voltage calculated in closed loop non-inverting amplifier?
Explanation: Although, the input is given to the non-inverting terminal of op-amp, the difference voltage is equal to the input voltage minus feedback voltage is Vid= Vin – Vf.
4. Why the feedback circuit is said to be negative for voltage series feedback amplifier?
Explanation: Voltage series feedback amplifier have the difference voltage, Vid = Vin-Vf. Therefore, the feedback voltage always opposes the input voltage and is out of phase by 180o with respect to input voltage. Hence, the feedback is said to be negative.
5. Determine the closed loop voltage gain from the given circuit. (Where gain of op-amp= 105).
6. Express closed loop voltage gain (AF) in terms of open loop gain (A) and feedback circuit gain (B)?
Explanation: The closed loop voltage gain in terms of open loop gain and feedback circuit gain is expressed as AF = A/(1+AB).
7. Which factor determines the gain of the voltage series feedback amplifier?
Explanation: In setting the gain of the voltage series feedback amplifier, the ratio of two resistors is important and not the absolute value of these resistors. For example: If a gain of 11 is desired, we choose R1=1kΩ and R1=10kΩ or R1=100Ω and RF= 1kΩ.
8. For the feedback circuit of voltage series feedback amplifier, find the feedback voltage for the specifications: R1=1kΩ, RF = 10kΩ and Vo= 25v.
The feedback voltage, Vf = (R1*Vo)/(R1+RF) = (1kΩ*25v)/(1kΩ+10kΩ) = 2.272v ≅ 2.3v.
9. What must be the value of external components used in voltage series feedback amplifier?
Explanation: All external components value should be less than 1MΩ. So, that they do not adversely affect the internal circuitry of the op-amp.
10. Find the block diagram representation of non-inverting amplifier with feedback?
Explanation: The mentioned block diagram is the standard form for representing a system with feedback.
11. Define the input resistance with feedback for voltage series feedback amplifier?
Explanation: In feedback amplifier, the input resistance of the op-amp with feedback is (1+AB) times that of without feedback.
Explanation: When the input at both the terminal are equal, the difference input voltage, Vid=Vin1– Vin2.
the closed loop voltage gain, AF= Vo/ Vin = 1+ (RF/ R1).


Short-term family health insurance can be required for those who are in between jobs, without coverage for any length of time and for those who are in transition between other work plans. Short-term health insurance coverage is available for as short as three months for up to a year. Short term insurance could be more expensive in some ways, but you will definitely be securing your finances in case something happens during that time when you do not have the full coverage your family had otherwise.
Short-term health insurance is a plan that you can get for just a few months. Short term insurance does not have to be something you pay a lot of money for if you're choosing a plan that covers just hospital visits, etc. If you choose a short term plan that covers the major bills, or major illness factors you can still have the protection against things that could happen in life without any worries.
Perhaps you are in between jobs, and your new health insurance does not kick in for six months, short-term health insurance can give you the coverage you need during this time, without the worry of any accidents occurring and using up all your savings.
Apply for health insurance as if you were going to get it for years. You do not have to tell the private company that you're going to need it just for a few months. You just pay the premium for a few months and then cancel your insurance when you do not need it any longer. Some companies will offer certain packages for a short term insurance, but you'll have to compare the rates and coverages as well.
Generally, the rates are going to be higher because you need it just for a short while, but if you compare with the other regular coverage you have available, you may find your best savings. Read, compare and then purchase for the best decision making process when getting health insurance.
For the simple reason that you just never know when an accident could happen, you need some type of short term insurance. Cover those medical bills so you're not creating debt that you'll have to worry about for years to come.
If you never use short term insurance, you do not have to worry about the money spent, because it could have always been worse if someone had an accident. Short term insurance is a protection for your future. Short term insurance is not a commitment for years to come, but just for a few months, so even if it's more expensive right now than what you could afford other wise, you must look at it, because you do not need to pay that bill forever each month. You have other insurance coming, so you know your medical bills will be covered in the long run too.
You do not have to stick with this company if you do not like them forever. Just get through this point in your life and good things will happen later as you start that new job, or you move to the new state or as you find other better health insurance.
The family health insurance assistance program is here to help you with every need in learning about health insurance. Health insurance is what your family needs for those unexpected events and needs in life. If you're under pressure to get health insurance because you have no benefits at work, you can find some inexpensive alternatives to your needs here on these pages. We have various types of insurance companies listed with various plans offered.
Lost Your Job Or Taking On A New One?
If you're without health insurance at the moment because of a change in careers or perhaps you've lost your job, you can find health insurance that will cover your family during that time. Your family's health is important and there are many stages in life where sickness and accidents happen and where check ups are required. With health coverage, you can get to the doctor or the hospital as you need to, without the worry about the medical bills that will follow.
Different types of health insurance are available for different budgets, and different medical needs. If you have pre-existing conditions, you may find that basic health insurance coverage will be what you need to improve your budget in the long run. If you have no pre-existing conditions, you can qualify for some types of plans that are more intensive but with a lower payment rate. Make sure you list all your conditions and needs when filling out the insurance quote inquiry forms for the most accurate rates that will apply for your entire family coverage needs.
Health insurance quotes are available for your review online. You can find information on how much it would cost you monthly or quarterly. Quotes will not oblige you to apply with or 'go with' any one insurance company, it's simply a tool for your use in understanding how much the price may be for the benefits you want for your family. Apply for a quote by giving the age, gender, and information about your family's medical history and current medical condition.
Look for all the benefits you have always wanted in a health insurance program when reviewing the information you find online. If you travel a lot and you want nationwide coverage, check the rates out, if you need limited coverage, look for coverage through a managed care plan for the lowest possible rates for your needs.


The Drava River - Part two - Cooking along the Drava. Croatian traditional food, travel and landscape.
One thing I've always liked is the long dirt road that needs to be done to get closer to the water. It's like a no-man's land left to itself. Also here you see marshes, wild trees, fallen branches, tangled creepers. The vegetation is everywhere very thick and sometimes the sun's rays can penetrate creating magnificent light effects.
Reaching the river means crossing the wild vegetation that surrounds it. Among marshes, silences and mystic lights.
This is the second part of the story on the Drava river. If you have not read the first part yet, you can click here.
These places are full of memories for me.
For example it was just among these trees that one day we had a barbecue, because the river water was very high and we couldn't reach the beach. That day I sat on a fallen tree trunk in a bathing suit, and for the first time I felt how painful it can be to be pinched by red ants. An incredible pain and burning that persisted over time.
It's right here that I saw my first leech.
And I remember that many times we did this road by bike, at full speed, screaming like crazy, and whipping us with some branches, to avoid being points from clouds of horseflies that chased us.
But, despite everything, every time I walk this road through the trees, I feel the magic.
This fall I managed to take pictures of the vegetation while changing color. The leaves were falling continuously and it seemed that it was raining. Shame not to have made a video. Next time.
Here at the river I learned to make holes in the sand. Or better: to make traps.
It's easy, just follow some simple rules.
The first rule is to dig a deep hole away from your place at the beach. So that, if someone falls into it, it is difficult to go back to you.
Second point: dig a deep hole. Better if narrow and long, because the chances of someone falling into it increase. The hole must have vertical walls.
Now begins the most delicate phase: covering the hole without leaving any trace of it. We must be able to cover it with a very light structure, made of twigs, shrubs and leaves. If the structure is too light, it will embark under the weight of the sand, if it is too solid you risk walking on it without sinking.
We need to create a first plot of thin branches. They must be placed at regular distances, covering the shortest distance. Then move on to a second layer of even thinner branches, better if reeds, hatched in the other direction. At this point, the best thing is to get some sheets of newspaper, otherwise you are forced to use large leaves, because it is necessary to create a layer that does not let the sand pass.
Then you have to cover everything with a thin layer of dry sand. Of course you also need to get rid of the pile of dug, damp and dark sand, trying to distribute it and cover it with dry sand.
Then you have to move away and lurk in a safe place, and wait for someone to fall into it.
I know, it sounds like a perverse game, but we kids always had a lot of fun. Needless to say: every hole that was made was bigger, deeper and more ambitious than the previous one. One day we reached perfection. Almost we ourselves could no longer recognize where the hole was. And we waited and waited. In the end, unexpectedly, we see our uncle returning from the store of drinks, exactly on the path of the hole. Well, my uncle was not very tall, and he almost disappeared inside the hole. We had to go get him out of there, despite being a great sportsman, football coach.
That was the last hole we dug. The perfect one.
See in the film "Sonatine", after many years, running the same kind of holes in the sand, with the same techniques, has filled me with joy. Thanks, Takeshi.
The river is the border between Croatia and Hungary, and until recently, there was a ban on taking photographs. In fact, all these years, I have no picture of all the time spent here. But now I have been able to do many: in summer, at sunset and in autumn. Let me know what you think about it.


Loyalty programs can be a highly effective way to build brand loyalty and encourage new brand advocates. From periodic discounts or rewards for promoting the brand, membership certainly has its benefits. And no one benefits more than the brand. But there is much more that a brand can do with loyalty programs and much more to be gained - including increasing time-on-site, page views, ad impressions and click-throughs, and direct sales.
Let's take a look at one such loyalty program, offered by Chicago radio station WXRT, at 93.1 FM and www.wxrt.com. Their program is called the VIP Lounge and features several outstanding uses of brand loyalty.
Below is an image of the home page after logging-in to the VIP Lounge. We first see the brand, clear and present, with the identifiable moniker of "93 XRT" and call-sign diamond in the logo. The page is immediately inviting as a place to relax and spend some time exploring - a nice touch with the couch and a personalized invitation with the welcoming video. Of course, the VIP's name is prominent, as is his or her status and balance of VIP points. Altogether, the user is made to feel very welcome and encouraged to explore the brand (more on that later).
VIP points are earned by interacting with the website and the radio station offline. The points can then be spent on promotional items - such as tickets to concerts or passes to events. For example, one entry for a free ticket to a local concert might "cost" 10 points. It's then up to the user to decide how many points to spend - the more points spent, the more entries and better chance of success to win the tickets. Instead of simply shipping a product when the user reaches a certain threshold, the user is given control of their loyalty. This gives them a reason to get excited and, more important, to come back and keep trying. Users can also spend their points on merchandise. Options.
Let's now look at one way for users to earn points. To the right is an image of blues legend BB King, who will be making an appearance at Chicago's House of Blues, a WXRT-sponsored event. On that photo is a call-to-action - 250 VIP points using the keyword "BB." By entering this code in the "Spend VIP Points" section at the VIP Lounge, the user earns 250 points that they can use to enter to win tickets to any number of WXRT concerts including BB King. Synergy.
Sure, we want our users to benefit from loyalty programs. More important, however, our brands and our bottom line needs to benefit. Going back to the VIP Lounge home page, we can see several important branding elements and opportunities.
The most striking element of the page is designed first and foremost for brand interaction - the red buttons. There are links to earning and spending VIP points, listening to the radio station live (cross-channel promotion), 'giveaways,' 'photos,' and the ever-important 'refer friend.' The referral is accomplished by an e-mail invite and rewarded by additional VIP points for each friend referred, and 10 percent of VIP points earned by those friends within the first seven days of their signup. In other words, the user becomes a loyalty program affiliate. Brilliant. There is also a prominent 'contact' button. After all, what good is being a VIP if you don't get personalized VIP treatment?
Also highly visible are a few direct revenue generators; in the casino ad, the "Big Holiday Concert" ad and another casino ad at the very top of the page (not pictured).
One of the most imporant features of this page and the VIP Lounge in general is the benefit to the website's statistics, which become highly relevant to prospective advertisers. By the time you reach the VIP Lounge you've already created a few page views. The multiple interactions available also encourage more page views and increased time-on-site, including photos and the video welcome message. Now, back to the BB King photo - this was the last of at least two dozen photos in the gallery. The gallery is promoted as offering 250 VIP points by looking for the keyword. So, the user must click through many other photos before reaching the last one, containing the keyword "BB." That's a tremendous way to get people to spend more time on the page, while giving something in return and even entertaining them.
Of course, a successful loyalty program requires promotion and maintenance. WXRT has more than 12,000 Facebook Fans and over 3,300 Twitter followers. The BB King promotion (along with all the others) are promoted heavily through both channels. Viral Marketing.
It should be noted that WXRT is no stranger to brand loyalty. The purveyors of "Chicago's Finest Rock" have been building a community and a following of Chicago music fans since about 1972. They have enjoyed loyal fans well before the Web had any impact on business, or even existed. But these elements are a fine example of brand loyalty objectives, benefits, and strategies that any business can employ.


How Far is Reliance Umanagar Galaxy?
Reliance Umanagar Galaxy is a residential project of Reliance Builders that is located in Begumpet, Hyderabad. It offers apartments with all the basic amenities like parking area to facilitate the life of residents.


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This year's Easter Fun Festival at Churchill Island is set to be bigger and better than ever when the cast of Madagascar and Alvin and the Chipmunks perform live shows across two big days.
Join in the fun on Saturday 30 March when Alex the Lion learns how to juggle and hula hoop in the Madagascar live show. Learn some classic circus moves with Alex who'll be joined on stage by a circus ringleader and some crazy clowns.
The fun continues on Sunday 31 March with everyone's favourite chipmunks – Alvin, Simon and Theodore. Dance and sing along to the exciting 'Chipwrecked' show with fun-loving Alvin and gang. And don't forget – you can meet the characters at noon.
Just 90 minutes from Melbourne, the Churchill Island Easter Fun Festival is action-packed with activities for the whole family. From 10am to 4:30pm catch the Magic Punch and Judy show, Pockets the Clown, Tall Poppy stilt walker, working horses, Historic Cars and Caravans, plus live music and food stalls. And don't forget the free Kids activity shows bags to be given away and free Easter eggs on Sunday for the kids.
Shows at 11a.m. and 1p.m. on Saturday and Sunday.


Steem Monster Treasure Chest Riddle.
To Solve This Puzzle And Open The Spoils.
You Must Become Completely Foiled.
You Must Become Confused And Toiled.
The Hardest Workers Open The Chest.
The Key To Open Is Owning The Best.
What You Own Must Shine Beyond The Rest.
To Open The Chest You Must Own All 10 Dragons.
But If You Own Too Many Cards, You May Be Lacking.
If This Puzzle Is Too Hard, Simply Start With The Rarest Card.