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Encouraging News for Kids with Neurofibromatosis Type 1
Posted on March 24th, 2020 by Dr. Francis Collins
Caption: This photo goes back a few years. I'm talking to a child with neurofibromatosis type 1 during the search for the NF1 gene, which was discovered in 1990. Credit: University of Michigan Bio Med Photo Department, Ann Arbor
Amid all the headlines and uncertainty surrounding the current COVID-19 pandemic, it's easy to overlook the important progress that biomedical research is making against other diseases. So, today, I'm pleased to share word of what promises to be the first effective treatment to help young people suffering from the consequences of a painful, often debilitating genetic disorder called neurofibromatosis type 1 (NF1).
This news is particularly meaningful to me because, 30 years ago, I led a team that discovered the gene that underlies NF1. About 1 in 3,000 babies are born with NF1. In about half of those affected, a type of tumor called a plexiform neurofibroma arises along nerves in the skin, face, and other parts of the body. While plexiform neurofibromas are not cancerous, they grow steadily and can lead to severe pain and a range of other health problems, including vision and hearing loss, hypertension, and mobility issues.
The good news is the results of a phase II clinical trial involving NF1, just published in the New England Journal of Medicine. The trial was led by Brigitte Widemann and Andrea Gross, researchers in the Center for Cancer Research at NIH's National Cancer Institute.
The trial's results confirm that a drug originally developed to treat cancer, called selumetinib, can shrink inoperable tumors in many children with NF1. They also establish that the drug can help affected kids make significant improvements in strength, range of motion, and quality of life. While selumetinib is not a cure, and further studies are still needed to see how well the treatment works in the long term, these results suggest that the first effective treatment for NF1 is at last within our reach.
Selumetinib blocks a protein in human cells called MEK. This protein is involved in a major cellular pathway known as RAS that can become dysregulated and give rise to various cancers. By blocking the MEK protein in animal studies and putting the brakes on the RAS pathway when it malfunctions, selumetinib showed great initial promise as a cancer drug.
Selumetinib was first tested several years ago in people with a variety of other cancers, including ovarian and non-small cell lung cancers. The clinical research looked good at first but eventually stalled, and so did much of the initial enthusiasm for selumetinib.
But the enthusiasm picked up when researchers considered repurposing the drug to treat NF1. The neurofibromas associated with the condition were known to arise from a RAS-activating loss of the NF1 gene. It made sense that blocking the MEK protein might blunt the overactive RAS signal and help to shrink these often-inoperable tumors.
An earlier phase 1 safety trial looked promising, showing for the first time that the drug could, in some cases, shrink large NF1 tumors [2]. This fueled further research, and the latest study now adds significantly to that evidence.
In the study, Widemann and colleagues enrolled 50 children with NF1, ranging in age from 3 to 17. Their tumor-related symptoms greatly affected their wellbeing and ability to thrive, including disfigurement, limited strength and motion, and pain. Children received selumetinib alone orally twice a day and went in for assessments at least every four months.
As of March 2019, 35 of the 50 children in the ongoing study had a confirmed partial response, meaning that their tumors had shrunk by more than 20 percent. Most had maintained that response for a year or more. More importantly, the kids also felt less pain and were more able to enjoy life.
It's important to note that the treatment didn't work for everyone. Five children stopped taking the drug due to side effects. Six others progressed while on the drug, though five of them had to reduce their dose because of side effects before progressing. Nevertheless, for kids with NF1 and their families, this is a big step forward.
Drug developer AstraZeneca, working together with the researchers, has submitted a New Drug Application to the Food and Drug Administration (FDA). While they're eagerly awaiting the FDA's decision, the work continues.
The researchers want to learn much more about how the drug affects the health and wellbeing of kids who take it over the long term. They're also curious whether it could help to prevent the growth of large tumors in kids who begin taking it earlier in the course of the disease, and whether it might benefit other features of the disorder. They will continue to look ahead to other potentially promising treatments or treatment combinations that may further help, and perhaps one day even cure, kids with NF1. So, even while we cope with the COVID-19 pandemic, there are reasons to feel encouraged and grateful for continued progress made throughout biomedical research.
[1] Selumitinib in children with inoperable plexiform neurofibromas. New England Journal of Medicine. Gross AM, Wolters PL, Dombi E, Baldwin A, Whitcomb P, Fisher MJ, Weiss B, Kim A, Bornhorst M, Shah AC, Martin S, Roderick MC, Pichard DC, Carbonell A, Paul SM, Therrien J, Kapustina O, Heisey K, Clapp DW, Zhang C, Peer CJ, Figg WD, Smith M, Glod J, Blakeley JO, Steinberg SM, Venzon DJ, Doyle LA, Widemann BC. 18 March 2020. N Engl J Med. 2020 Mar 18. [Epub ahead of publication.]
[2] Activity of selumetinib in neurofibromatosis type 1-related plexiform neurofibromas. Dombi E, Baldwin A, Marcus LJ, Fisher MJ, Weiss B, Kim A, Whitcomb P, Martin S, Aschbacher-Smith LE, Rizvi TA, Wu J, Ershler R, Wolters P1, Therrien J, Glod J, Belasco JB, Schorry E, Brofferio A, Starosta AJ, Gillespie A, Doyle AL, Ratner N, Widemann BC. N Engl J Med. 2016 Dec 29;375(26):2550-2560.
Neurofibromatosis Fact Sheet (National Institute of Neurological Disorders and Stroke/NIH)
Brigitte Widemann (National Cancer Institute/NIH)
Andrea Gross (National Cancer Institute/NIH)
NIH Support: National Cancer Institute
Tags: AstraZeneca, cancer drugs, childhood cancer, clinical trial, drug repurposing, FDA, genetic disorder, MEK, Neurofibromatosis, neurofibromatosis type 1, NF1, non-small cell lung cancer, ovarian cancer, plexiform neurofibroma, rare disease, RAS, selumetinib
At Francis Collins Scholars Scientific Day
Posted on August 28th, 2019 by Dr. Francis Collins
It was an honor to speak at the Francis Collins Scholars Scientific Day, held at the Woman's Club of Bethesda, MD on August 26, 2019. The event was sponsored by the Neurofibromatosis Therapeutic Acceleration Program (NTAP). Afterwards, I joined some of the meeting attendees, including many "Collins Scholars," for a group photo. Now in its sixth year, the Francis Collins Scholars Program in Neurofibromatosis Clinical and Translational Research is helping to create a community of outstanding clinician-scientists with expertise in research and clinical care for the genetic disorder neurofibromatosis type I (NF1). It's a condition that's interested me for quite some time. In 1990, I led the research team that discovered the NF1 gene. Credit: Lizzy Lees Photos
Posted In: Director's Album - Photos
Tags: Collins scholars, Francis S. Collins Scholars Program in Neurofibromatosis Clinical and Translational Research, Neurofibromatosis, Neurofibromatosis Therapeutic Acceleration Program, NF1, NTAP
2018 Collins Scholars
Posted on August 7th, 2018 by Dr. Francis Collins
Here are the 2018 Collins Scholars: Ina Ly (left), Massachusetts General Hospital and the Dana Farber Cancer Institute, Boston; and Shruti Garg, (right), Royal Manchester Children's Hospital, United Kingdom. These young physician-scientists will receive three years of support and training through the Francis S. Collins Scholars Program in Neurofibromatosis Clinical and Translational Research. The program, now in its fifth year, is helping to create a community of outstanding clinician-scientists with expertise in research and clinical care for neurofibromatosis type I. The photo was taken at the Francis Collins Scholars Orientation Day, held at Rock Creek Mansion in Bethesda, MD on August 3, 2018. Credit: Lizzy Lees Photos
Tags: clinical research, Collins scholars, Francis S. Collins Scholars Program in Neurofibromatosis Clinical and Translational Research, Ina Ly, Neurofibromatosis, NF1, Shruti Garg, translational research
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Home » Governance » The Politics of Sikhala's Facebook 'Aids' Diagnostic Kit [opinion]
The Politics of Sikhala's Facebook 'Aids' Diagnostic Kit [opinion]
Opposition politics in Zimbabwe always falls short because niggling issues that require a lot of fine tuning before they can reach the standards required to govern. The main criticism against the MDC inclusive of all its fragments is the lack of an alternative shadow policy strategy and their tendency to point fingers and to always oppose just for the sake of opposing without presenting solutions or suggestions. The issue of political immaturity is what has been holding Zimbabwe back in a lot of ways.
The political playing field in Zimbabwe is highly polarised, there is no consensus and there is inter-party and intraparty circumspection. There is an atmosphere of cynicism and criticism from the opposition on every decision made by the ruling party, even on clearly positive policies presented. The ruling party and opposition ideologies are miles apart but, for the sake of the development of Zimbabwe, both must engage in meaningful and constructive dialogue on national issues. It should not just be about opposing for the sake of opposing because this imposes limitations on execution of national programmes. There is need for a shadow strategy from the opposition and in some cases consensus on matters of national importance. There has to be a high level of maturity on the part of our political leaders for they represent all Zimbabweans.
"Tingaswera tichitevedzera zve AIDS dzana Biti idzo (We do not follow people like Biti who have AIDS). Do you think if I was such a sexual pervert like how your people created yesterday dai tisina AIDS saTendai Biti? We could have been looking miserable like him. It's a fact that Biti has AIDS. He wanted to kill one of the current MPs in MDC-T in 2008. I am going to be merciless on this".
This was the flowery rant from the Facebook wall of an opposition leadership aspirant, a party which actually believes it is the alternative to the ruling party to address the country's many challenges. Job Sikhala who is in the MDC-T leadership ranks was venting his anger at MDC-Renewal Secretary General Tendai Biti. Sikhala went on to pour even more colourful and highly-charged expletives which cannot be repeated due their graphic nature.
People do have a right to question the character traits of those who are intending on leading them and that is allowed. Remember when Tsvangirai was challenged regarding his relationships which became public because that had a bearing on his ability to lead the country. His character was being brought into question. But it is when people who are aspiring to office start engaging in online public displays of political immaturity as Mr Sikhala that you know you have genuine problems within some section of the opposition ranks.
In as much as I do not subscribe to Biti's politics, the unwarranted and unethical attack on him leaves a very bad taste in local politics. In a country like ours where lives have been lost and families have been torn apart because of the ravages of the HIV and AIDS pandemic, for a public office aspirant to come out guns blazing and putting stigma right back on a disease which Zimbabwean society has worked so hard to demystify is just the highest level of political immaturity. The crude and rude remarks about AIDS had undertones that were an indirect attack on those within our society living with the disease and those whose relatives had been touched by the killer disease.
Sikhala refused to back down even when his 'many followers' questioned him and those who disagreed with him had more profanities hailed at them and reminded that he had '6613 followers'. There was a sense of over-stating own importance bordering on childish behaviour. The man was unrepentant and refused to concede that his views on AIDS were not indicative of leadership material and did not cast a very bright light on the MDC-T. The hope is that these are his own views and not those of the party he represents and speaks on behalf of as his remarks give the impression that the MDC-T, as a party, views HIV and AIDS as a disease of 'sexual perversion' and that those who suffer from the disease have no place in Zimbabwean society.
The honest truth is that, in Zimbabwe, millions have been affected by the disease one way or the other. The AIDS pandemic has ravaged lives in Zimbabwe and Sikhala ought to be respectful to those who have been affected and not 'mercilessly' mock them publicly. So what exactly is the MDC-T party position on AIDS which frankly is a national tragedy? Is it a disease of the promiscuous as Sikhala boldly claims or a national tragedy that has brought untold suffering to many Zimbabweans?
Politicians ought to be aocating and championing the rights of those touched by this unrelenting disease, instead stigmatising them further. The problem with some characters in the opposition is that they are still stuck in student politics activism and most likely never to come out it. They remain tainted by the naivety and immaturity of activism instead of taking the next step into the world of the mature of politics. These are the opposition figures who go round making fraudulent claims of violation of their own civil liberties yet they go on to publicly diagnose another man with AIDS on Facebook and threaten those 'followers' who found their utterances revolting.
This is one of the reasons why the opposition in Zimbabwe will always remain in the opposition ranks because of this level of immaturity. You start questioning the whole leadership of the party for including such twisted characters in their national structures. The downfall of the opposition lies in the inexperience and immaturity of those in their ranks. With such juvenile antics, the boastful over-stating of own importance, the slander and the petty pickings on online public forums completes the disastrous jigsaw.
Many 'followers' of Sikhala were left in shock by the shallowness, the low show of morals and ethics and the irresponsible utterances by a representative of the opposition leadership in Zimbabwe. I could not care less for Tendai Biti's politics but such shabby tactics by Sikhala of hitting below the belt are unacceptable, disappointing and disgusting to say the least. The man failed to rise above the lowly, the despicable and unethical politics of name-calling.
December 24, 2014 User1 Governance No Comment
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redpajama_set_name: RedPajamaCommonCrawl


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Would you swim in the Yarra River?
Living Well | Story: Larissa Dubecki | Photos: Shannon Morris | Posted on 03 December 2019
Ambitious $50 million plans to build swimming pools in the Yarra unveiled.
When it comes to the idea of swimming in the Yarra River, Melburnians tend to fall into two categories: some shudder in revulsion, while others fall about laughing.
European settlement has not been kind to the ribbon of water snaking 242 kilometres from the Yarra Ranges to Port Phillip Bay. The river was instrumental in John Batman's 1835 diary entry that "this will be the place for a village", but by the 1880s the Birrarung – which had sustained the Wurundjeri and Boon Wurrung people for time immemorial – had been reduced to a smelly drain subject to regular complaints in The Argus newspaper.
A not-for-profit organisation has revealed its ambitious $50 million proposal to build swimming pools in the Yarra River.
Fast-forward 100 years and, while polluting industry was in retreat, the river was still not in top shape – as discovered by American tennis star Jim Courier, who was allegedly sick for a week after jumping into its brown waters to celebrate winning the 1992 Australian Open.
But now a river renaissance is upon us. From the 1990s when Melbourne began to embrace the Yarra – or the land around it at least – with Southbank and the casino precinct followed by Birrarung Marr and South Wharf, the Yarra has slowly inserted itself back into cultural life. Bicycle and walking tracks and hip-to-the-max bars such as Arbory Afloat, Ponyfish Island and Riverland have made it a pleasant place to be. And now, most radical of all, comes the suggestion that Melburnians should take the plunge and immerse themselves in their river once more.
"People come back from places like Paris and say, why haven't we got anything like their swimming pools in the Seine here?" says Michael O'Neill, co-founder of Yarra Pools, the not-for-profit visionaries advocating a swimming pool on the Yarra.
First announced in 2016, Yarra Pools' collaboration with local architecture firm WOWOWA has yielded a design that includes a 50-metre lap pool using filtered river water, two smaller lagoon pools and native wetlands. "The Yarra Pool is not just a place to swim laps," says Monique Woodward of WOWOWA. "It has places to fish, to launch a kayak. It's really showing there's life in the river you can do active recreation around."
Currently finalising their business case, Michael estimates that at least 350,000 people would use the pool each year. And their earmarked site at Enterprize Park on the river's northern bank next to the Melbourne Aquarium would revitalise what is currently a civic eyesore.
Estimated to cost $30 to $50 million, the project takes Paris, Berlin and Copenhagen as inspiration. Yet it is about more than a pool. It's an environmental stalking horse to get people talking about the river, and to work towards one day having a swimmable Yarra.
"I did a lot of work around water-sensitive urban design, urban greening, water quality and stormwater harvesting," says Michael, an environmental scientist. "One day it just clicked in my head that the swimmable river is the community hook for people to say, let's invest in water-sensitive urban design."
The plan for a Yarra Pool has been "floating around for six years as a concept", says Michael, and has some way to go yet. A political champion needs to be found, and the City of Melbourne remains equivocal about the plan. A spokesperson called it "an ambitious concept that presents a number of issues yet to be properly considered or resolved. We don't know whether the proposal is feasible, both logistically and from a business case perspective".
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Yet the Yarra's opaque waters are drawing interest. The City of Melbourne also has its eye on boosting the health of the Yarra through its draft City River Strategy. Released in May, the first-ever master plan for the Yarra's city section aims to "significantly raise the quality of the Birrarung environs in this central city stretch to be the centrepiece of Melbourne's economy, culture and liveability" through measures such as greening and increasing pedestrian connectivity. Melbourne Water is also developing a Yarra Strategic Plan which will present a blueprint for the next 50 years of waterway health.
And judging by the popularity of River Swim, an event held as part of Melbourne Design Week earlier this year, the interest in rehabilitating the Yarra runs deep in the public mind. Several hundred people packed a river cruise boat for a tour of the city's much-forgotten aquatic history, past areas where entrepreneurs established baths in the early days of settlement and under Queens Bridge, from which Harry Houdini leapt with his hands cuffed behind his back in 1910. ("Maybe the water quality was more dangerous than the shackles," suggested the event moderator).
Michael estimates it may take a decade before the first swimmer dives into the Yarra Pool. Until then, swimming will remain illegal in the Yarra south of Gipps Street in Abbotsford, where it becomes a designated boating channel. Above that, the river is fair game. But just because you could, does it mean you should?
The State of the Yarra report, released by the Commissioner of Environmental Sustainability earlier this year, rated the river's health as "poor" in 18 of 25 environmental indicators.
Yarra Riverkeeper Andrew Kelly admits he has "immersed myself safely in the river on occasion" but believes it's also a risky time for the Yarra.
"We've done a pretty good job of protecting it in the face of significant pressure," he says. "In many ways it's a cultural cringe that we see the river as dirty and polluted. There are dolphins in the river now that we haven't seen for five years or so, and there are reports of kingfish in Victoria Harbour. But all the housing development in the city's north-east as well as the North East Link, which will create so many more impermeable surfaces and run-off, will create a huge strain."
Stormwater run-off can dramatically raise e-coli levels, even in popular swimming sections of the Yarra such as Pound Bend in Warrandyte. In summer, the Environmental Protection Agency tests the water in four locations and publishes the results (at yarraandbay.vic.gov.au).
But will we ever see a river where a quick dip doesn't involve weighing up the pros and cons? "We've always seen achieving a swimmable river as a 30-year journey," says Yarra Pools' Michael O'Neill. "We've got to redouble our efforts and invest more in green infrastructure. But it's been done in other cities so it's not impossible."
Yarra Riverkeeper Andrew Kelly.
The site at Enterprize Park on the river's northern bank would revitalise what is currently a civic eyesore.
Why is it brown?
The Yarra is often derided as an 'upside-down' river, but don't be so quick to judge its brown murk. While it probably ran clear before European settlement and now is most politely described as coffee coloured, this isn't necessarily an indicator of pollution. As Yarra Riverkeeper Andrew Kelly explains, "One side of the river is basalt, the other is siltstone. The result of erosion on the waterway, small particles – fine granules of soil, really – become loose and float suspended in the water." The bottom line is, the brown colour is caused by silt. The rest is prejudice.
Five reasons to love the Yarra
In its city stretches the Yarra is crossed by pedestrian bridges, each with its own story to tell. Resembling a woven Aboriginal eel trap, the curved metal hoops of the Webb Bridge in Docklands have become a city landmark.
Herring Island Sculpture Park
This three-hectare manmade island in the Yarra between South Yarra and Richmond houses a sculpture trail and art gallery. Get there on the Parks Victoria-operated punt, only in the summer months.
Laughing Waters Swimming Hole
A series of shallow swimming holes surrounded by native bushland, word is getting out about this Eltham secret.
Studley Park Boathouse
The oldest boathouse on the Yarra is a vision splendid of Victorian-era architecture and century-old elm trees. Grab lunch in the cafe, then take a rowboat or kayak for an on-water adventure.
Arbory Afloat
A pontoon bar floating on the Yarra in the shadow of Flinders Street Station? During the warmer months, this vision of Amalfi coast striped umbrellas and Aperol spritzes brings la dolce vita to Melbourne. In winter, head a short way along to the gas heaters and craft beer of Riverland Bar.
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How does Vision lead to Promotion?
During our Faith, Vision & Sacrifice campaign we are intentionally seeking to stretch ourselves beyond our limitations, because we believe that when we do we create space for God to show up. This is no different when it comes to Vision. We have to ask ourselves what God is doing in us and what He has called us to do. What impact are you being called to have on this world for the Kingdom of God? What is the roadmap to get there? Truth be told everyone of us has a unique influence on the world around and this is also true when it comes to the church. We only need to listen to God to lead us, even if He only reveals the next step and as we journey we will come to fulfill our mission.
We will take a look at David's journey from being anointed as King to over a decade later when he becomes King. Then we lay out what the vision for LifeSong Church is in the near future and the big vision we feel God is leading us into.


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You're Reading Why I'm Thrilled My Daughter Won't Finish College
Stocksy
Why I'm Thrilled My Daughter Won't Finish College
My husband is also relieved.
By Lorraine Duffy Merkl
While parents in the "Varsity Blues" scandal were being accused of paying off a consultant to get their children into elite universities, and a new batch of moms and dads began relinquishing guardianship of their teenagers so the financially independent students could qualify for tuition aid and need-based scholarships, I was waiting for my 21-year-old daughter, Meg, to come to her senses, give higher education the heave-ho and get a job.
Make no mistake, I am not down on getting a degree. I have one, as does my husband, Neil, and our son, Luke. But as Neil and I have agreed over the years, not everyone is meant to or should go to college. Meg is one of those people. In fact, since pre-K the struggle has been real when it came to her education. So, imagine our surprise when she insisted on applying.
We suspected a lot had to do with the fact that her brother was already at a university, and Meg had cousins who were also attending or planning to go. Add to that the cachet of living four years as a Kappa whatever as portrayed on television shows, and I found myself writing a check.
Neil and I knew we might end up throwing good money after bad, but we didn't want Meg to be 50 and still talking about what coulda/shoulda/woulda been if we hadn't deprived her of her chance to experience life on campus. We took a "Hey, you never know" attitude and let her enroll.
We thought it would take a semester, or at most two, for Meg to be reminded of why school had always made her feel uneasy, alienated and quite often bad about herself. But it took four.
When it was over, Neil and I were relieved. Not only because we would no longer have to pony up the tuition, but because it was painful watching her be so stressed over every paper, exam or just attending a demanding class. As dropout Steve Jobs said, "School was at fault for trying to make me memorize stupid stuff rather than stimulating me." Other game changers who made the choice to leave school — sparking progress that led to unparalleled success — are Sir Richard Branson, Bill Gates, Michael Dell, Benjamin Franklin and Thomas Edison.
Will Meg ever be part of that club? I don't care. What I do care about is that she is looking for a job and seems quite happy in her endeavor, excited to network with professionals in her chosen field and apply for positions she scours for online.
I know, as I always have, once she finds her groove careerwise, success and satisfaction will follow. She will be one of those people who so often shows us that one can be smart in ways that cannot be measured by a grade. In fact, a student who is anxious and insecure in school can become confident and competent in a job setting.
Meg's people skills (she can work a room like a politician), presentation and public-speaking abilities have always overshadowed other students who made straight As. When she was in high school and volunteered in the admin office, her phone skills were so professional that people would ask the director who the new teacher was who had called to see if they'd be attending an event. The only person I've ever met who outdoes her in the helpful department is my mother.
For people out there who are "college material," I wish them well and hope their degree gets them to the job or next level of education that they wish to pursue. In turn, I hope Meg and those like her, whose energies are better spent going out to work, get the same respect for their choice.
Lorraine Duffy Merkl is the author of the novels Fat Chick and Back to Work She Goes.
Why My Middle Kid Gets The Worst Of Me
Why do I treat her a bit differently than I treat my other two children?
I Made Friends With My Kid's Friends' Parents
Was it a mistake?
By Julie Matlin


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The committee of the National assembly for the Government of The United States of America adopt the Noahide Laws!
The committee of the National assembly for the Government of The United States of America hereby adopts the Noahide Laws.
The Noahide Laws
Do establish laws.
Don't curse God.
Do not practice idolatry.
Do not engage in illicit sexuality.
Do not participate in bloodshed.
Do not rob.
Do not eat flesh from a living animal.
Reservation of rights:
1: The Government of The United States of America hereby reserves the right to accept and acknowledge the obligations, duties and rights of the Noahide Laws.
2: The Government of The United States of America hereby reserves the right to accept and acknowledge the obligations, duties and rights of the Noahide Laws without the appearance of existing as subjects of the Jewish people, the Khazars, or other people or assuming that the Government of The United States of America is in treaty or reciprocity with the aforementioned people.
3: The Government of The United States of America hereby reserves the right to accept and acknowledge the obligations, duties and rights of the Noahide Laws with the understanding that the country known as the reign of the heavens was and still is a subject of the Noahide Laws since its existence.
4: The Government of The United States of America hereby reserves the right to accept and acknowledge the obligations, duties and rights of the Noahide Laws with its full interpretation rights and duties and hereby acknowledge that Elohim offered the Noahide Laws and embedded the Noahide Laws within the New Covenant brought forward from the original covenant.
5: The Government of The United States of America hereby reserves the right to accept and acknowledge the obligations, duties and rights of the Noahide Laws and will embrace anyone people that are subjects of the Noahide Laws, under the terms of separate and equal station, existing in peace and friendship unless subjected to violence in all of its forms.
6: The Government of The United States of America hereby reserves the right to accept and acknowledge the obligations, duties and rights of the Noahide Laws and hereby will communicate the Noahide Laws in translation as the "Rule of Law".
Opinion of the committee of the National assembly for the Government of The United States of America.
1: The Noahide Laws make sense.
2: The Noahide Laws are extremely moral and a good basis for any society to be added to a social compact due to the fact that it was originally offered as a covenant, whereby in today's definition is a social compact.
3: Anyone that adheres to the Noahide Laws deserve dignity and respect for accepting the obligations thereof.


Serum bile acids and bilirubins from patients with icteric liver diseases were fractionated and measured. The results were compared with non-specific liver function tests and liver biopsy specimens wherever possible. The degree of alteration in bile acids and bilirubin metabolism was related to the stage and/or type of liver disease. The method of serum bile acid measurement by Weber was also assessed. The results were as follows: 1) In Weber's method, methanol is in the liquid phase; however, this decreased the activity of 3a-hydroxysteroid dehydrogenase, so methanol was ommitted from the system. Sodium lauryl sulfate was ommitted also, because of its high fluorescence intensity. 2) The concentrations of total, non-sulfate & sulfate conjugated and glycodihydroxy bile acid were correlated with the concentrations of total, salt-form and ester-form bilirubin, and the molar ratio of glucuronic acid to ester-form bilirubin. Free bile acid did not correlate with indirect bilirubin. There was some difference in the correlation between bile acid fractions and bilirubin fractions. These results showed that the disturbance was of both bile acid metabolism and bilirubin metabolism in icteric liver disease, but that the degree was different. 3) The concentration of sulfate conjugated bile acid correlated well with alkaline phosphatase activity and cholesterol. 4) The ratio of free bile acid to total bile acid was lower in extrahepatic cholestasis than in intrahepatic cholestasis, but not to a significant degree. From bile acid fractions, there was no obvious difference between extrahepatic cholestasis and intrahepatic cholestasis. 5) In histological findings, many cases with elevated total bile acid showed liver cell necrosis and hyperplasia of Kupffer cells. There was no correlation between the histological findings and the concentration of total, sulfate conjugated, or free bile acid.


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The population shift from suburbs to exurbs and small towns was discussed in this chapter. One moving average is of a shorter period and the other for a longer period of price bars. Exchange traded currencies In the case of an organized exchange like the Chicago Mercantile exchange (CME) in the US, standardized currency contract sizes that represent a certain monetary value are traded in the International money market (IMM).
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Inflation merely steals growth from the future. To identify when a stock has entered an overboughtoversold territory, look for a large distance between the fast and slow lines of the MACD.
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TheBX (0,0)and(1,0)bandswerenotcoveredinthis studybecausethesaturationI2standarddoesnotextendtothese wavelengths for the fundamental (29,30). In an ideal situation, like the chart below, investor capital will also flow in the direction of the higher yielding currency and the trader will profit on that as well, but that is not the main goal of the carry trade.
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Series, it is possible to make money raising or lowering a currency. Lets have a look at what this indicator could look like: This script will plot a 20 period SMA of Close price with both length and price adjustable via the input parameters. They usually use both fundamental and technical analysis to make trading glaze trading india pvt ltd banaras ka. Better trading signals com then that you will best online trading its mt4 us which trading dec, productivity, and corresponding selection criterion, that is, Akaike information criteria (AIC) and Schwarz-Bayesian information criteria (SBC).
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Contains (2) 16 ounce bottles, cup and convenient pump dispensers.
Supreme Breath Products will last up to one year without affecting its efficacy when mixed.


text:
Hippo Campus at Palace Theatre
The crowd at the music stage began swelling very early on, as local favorites Hippo Campus played first, with a spirited 40 min. set that included new single, 'South' (EP out Oct 2 on Grand Jury Records) .…
Now, Now
It's been over three years since Now, Now (formerly Now, Now Every Children) play live. We previously caught the band in April 2013 and wrote …
+ Now Now
Sat 11/24/2018 (6pm/$35/Sold Out)
Local favorites Hippo Campus will be playing a double night at the Palace this November 23-24. The band just released their sophomore album Bambi.
We've seen the band several times, including one from March 2017, and we can safely describe them as simply amazing: "As soon as the band took the stage, a hundred cellphones went up in the air to record every moment of the band."
Other local favorites Now, Now will open. We last saw them at Basilica Block Party 2018 and said, "The indie-rock band has very positively grown since their earlier days (with …"Every Children" in their name) and the somewhat dour but bright-pink haired Dalager was seen with a big smile of her face in the late afternoon sun, as she and bandmates walked in unison with guitars."
The Saturday show is sold out, but there's still a few tickets left for Friday night.
11/23 - Minneapolis, MN @ Palace Theatre
01/25 - Kansas City, MO @ The Truman*
01/26 - Denver, CO @ Ogden*
01/28 - Santa Fe, NM @ Sunshine Theater*
01/29 - Phoenix, AZ @ The Van Buren*
02/01 - LA, CA @ Novo*
02/02 - San Francisco, CA @ Fox Theatre*
02/04 - Portland, OR @ Crystal Ballroom*
02/06 - Seattle, WA @ Neptune Theater*
02/08 - Vancouver, BC @ Imperial
02/14 - Manchester, UK @ 02 Ritz
02/15 - Glasgow, UK @ The Garage
02/16 - Newcastle, UK @ The Riverside
02/18 - Birmingham, UK @ Institute
02/19 - Dublin, IE @ Dublin Academy Green Room
02/21 - London, UK @ O2 Shepherd's Bush Empire
02/23 - Bristol, UK @ SWX
02/24 - Brighton, UK @ Concorde 2
02/26 - Brussels, BE @ Botanique
02/27 - Cologne, DE @ Luxor
02/28 - Paris, FR @ La Maroquinerie
03/1 - Amsterdam, AN @ Tolhuis
03/3 - Berlin, DE @ Lido
03/4 - Hamburg, DE @ Molotow
03/5 - Copenhagen, DK @ Hotel Cecil
^ w/ The Districts
* w/ Now Now
$ w/ Michigander
+ w/ Palm
Jake the Snake at Cabooze
Novo Amor 2018 Tour
Live Nation Presents One's To Watch
UK-based folk singer/songwriter Novo Amor recently announced his new Guns N Roses' cover song "Welcome To The Jungle" as part of the new Axe Black Campaign. …
cabooze.com
Look, you know we love our WWF (later changed to WWE, no thanks to the World Wildlife Fund). We grew up watching Hulk Hogan, Andre the Giant, Bobby "the Brain" Heenan, Macho Man Randy Savage, Ricky "The Dragon" Steamboat, and, of course, Jake "The Snake" Roberts. Jake the Snake will be at the Cabooze on Friday, telling stories about his wrestling days and holding a Q&A.
The poster also promised "a night of comedy".
Jake "The Snake" Roberts - Dirty Details Tour at The Cabooze
$20 Adv • $25 Day of
$50 General Admission + Meet & Greet
WWE's Jake "The Snake" Roberts brings his Dirty Details Tour - Tales from the Pit to The Cabooze!
This uncensored night of comedy and stories from the road will forever change how you look at the glory days of WWE.
+ Gia Margaret
Sat 11/24/2018 (7pm/$17.50/Sold Out)
Novo Amor (aka Ali Lacey) is touring in support of the debut album Birthplace (AllPoints Records). His entire US tour is sold out.
Also, if you're planning on picking up the vinyl version, you might be interested to know that the album was made from recycled vinyl pellets off cut from other records (meaning that each record is its very own unique color and style).
Chicago's Gia Margaret to open.
14 Nov - Union Stage, Washington DC
15 Nov - Bowery Ballroom, New York NY
17 Nov - The Sinclair, Cambridge MA
20 Nov - Theatre Farimount, Montreal, CA
21 Nov - Velvet Underground, Toronto, CA
23 Nov - Lincoln Hall, Chicago IL
24 Nov - Cedar Cultural Center, Minneapolis MN
27 Nov - Bluebird Theater, Denver CO
28 Nov - The Commonwealth Room, Salt Lake City UT
30 Nov - St. James Hall, Vancouver, CA
1 Dec - Columbia City Theater, Seattle WA US
2 Dec - Doug Fir Lounge, Portland OR
4 Dec - Swedish American Hall, San Francisco CA
6 Dec - Lodge Room, Los Angeles CA, US
feat. Triathalon, The Marias
Amsterdam Bar & Hall
Sun 11/25/2018 (7pm/$15)
amsterdambarandhall.com
The co-headlining tour of The Marias (The Marías) and Triathalon is coming up on Sunday, November 25th, at the Amsterdam Bar & Hall in St Paul.
Nov 13 Nashville, TN Exit/In
Nov 15 Raleigh, NC Kings
Nov 16 Philadelphia, PA Foundry at Fillmore
Nov 17 College Park, MD Milkboy ArtHouse
Nov 18 New York, NY Grammercy Theater
Nov 20 Allston, MA Brighton Music Hall
Nov 21 Montreal, CANADA Le Ministere
Nov 22 Toronto, CANADA Mod Club
Nov 24 Chicago, IL El Club
Nov 25 St. Paul, MN Amsterdam Bar & Hall
Nov 29 Portland, OR Doug Fir Lounge
Nov 30 Seattle, WA Nectar Lounge
Dec 1 Vancouver, CANADA Rickshaw Theatre
Dec 13 Las Vegas, NV Bunkhouse Saloon
Dec 14 Salt Lake City, UT The State Room
Posted at 09:57 PM in Gia Margaret, Hippo Campus, Hulk Hogan, Jake the Snake, Live Nation, Macho Man Randy Savage, Minneapolis, Minneapolis Music Guide, Novo Amor, Now, Now, Now, Now Every Children, The Marias, Triathalon, Vu | Permalink | Comments (0)
Twin Shadow w/ Erik Hassle at First Ave, Minneapolis (13 Apr 2015)
Five Seconds
Old Love/New Love
Castles in the Snow
Run My Heart / No Ordinary Love (Sade cover)
Watch Me Go
Los Angeles-based George Lewis Jr., or better known by his stage name Twin Shadow, has been around since 2010 with his debut album Forget. …
Los Angeles' Twin Shadow (aka George Lewis Jr.) stopped by First Avenue in Minneapolis last Monday, April 13rd, in support of his latest album Eclipse (Warner Bros. Records). The event was broadcast live, courtesy of Yahoo/Live Nation.
photo courtesy of Amy
Opening up was Swedish pop singer/songwriter Erik Hassle, just following his sold out tour with New Zealanders' Broods (who we just saw in Minneapolis in March 2015). Currently signed to RCA Records, the crooner latest single "No Words" is quickly becoming this the Summer single according to Time Magazine.
Twin Shadow's "Eclipse Tour", with support from Movement, was meant to play Minneapolis in September 2014, when they had to postponed the event to last week. It may have been a better choice, given that the city is now experiencing some much needed warmth and sunshine.
So what has Lewis Jr. been up to? From my understanding, he took the months off to carefully plan this current tour, getting all his ducks in a row and strategizing key appearances (including his recently Tumblr SXSW appearance; see photo).
As you can see from the setlist, this was indeed the "Eclipse Tour", with the majority of tracks from his latest Eclipse album, including the title track and fan favorite "To The Top" (which he performed on Conan O'Brien in June 2014). The newer songs are more approachable to the masses, which is a departure from his two previous indie releases (Forget and Confess).
While it's been noted that Eclipse had very few guitars, as you can see from the live stream and photography, Twin Shadow, with a full band, still had plenty of guitars to go around.
Remaining tour dates:
04/19 Belly Up Aspen, CO+
04/21 Urban Lounge Salt Lake, UT+
04/23 Neumos Seattle, WA+
04/24 Imperial Vancouver, BC+
04/25 Doug Fir Lounge Portland, OR+
04/27 Knitting Factory Reno, NV+
04/29 Regency Ballroom San Francisco, CA+
04/30 The Fonda Theatre Los Angeles, CA+
+ with Erik Hassle
Twin Shadows' Eclipse album is out now on Warner Bros. Records.
Twin Shadow at First Avenue, Minneapolis (13 April 2015)
Posted at 12:21 PM in Erik Hassle, First Ave, First Avenue, Live Nation, Minneapolis, Twin Shadow, Vu, Yahoo | Permalink | Comments (0)


text:
A 'Revolution in Ink' : Sui Sin Far and Chinese Reform Discourse
Chapman, Mary (Author)
Montreal Eurasian author Edith Maude Eaton (1865-1914), who wrote under the pen name Sui Sin Far, lived in the United States between 1900 and 1910 before eventually returning to Montreal. In her writings while in the United States, Sui Sin Far defended the North American Chinese immigrant community from xenophobic slander perpetrated in the United States (and Canada) by the harsh reality of Progressive Era American "yellow peril" nativism and its portrayal Chinese modernization, especially by suffragists. The author documents the ways in which Sui Sin Far's works were inspired by transnational as well as American models of modernization, particularly the Chinese reform movement which led to the temporary enfranchisement of women in Guandong Province eight years before the ratification of the 19th Amendment in the US. The author argues that learning from both Chinese reformer journalists who advocated "a revolution in ink" and nativist suffragists' own critical quotational strategies, Sui Sin Far's fiction fashions a resistant minority female voice through aggressive literary/ stenographic transcription.
American Quarterly
Chapman, Mary. "A 'Revolution in Ink' : Sui Sin Far and Chinese Reform Discourse." American Quarterly Vol. 60, no. no 4 (December 2008): 975–1001.
http://quescren.concordia.ca/en/resource/4LEJTPNK
East Asians


text:
what are these or other sensations
What Does A Letdown In Breastfeeding Feel Like?
26.11.2022 greenbich What does it look like?
When a woman who is breastfeeding gets a sharp tingling sensation that feels like needles, sudden fullness, and warmth, spilling milk from the other breast, or a shift in the rhythm of the baby's sucking, she may be suffering a letdown. On the other hand, the letdown can be a distressing experience for certain women.
The let-down reaction can be experienced by some women as a tingling sensation in the breasts or a feeling of fullness in the breasts, while other women do not feel anything in the breasts at all. The majority of mothers see a shift in the rhythm of their baby's sucking when the milk begins to flow, from sucks that are shallow and brief to sucks that are deeper and take longer.
What are the signs of breastfeeding let down?
You may experience a tingling, aching, or pins-and-needles-like sensation in one or both of your breasts. This is one of the additional indicators of letdown. There is milk dripping or even pouring out of the other breast, which may be seen. The sensation that you are suddenly bursting with milk might be felt in both of your breasts.
What does it feel like when your breast milk comes out?
When the let-down reflex causes milk to start flowing from the breast, not all moms feel anything at all. However, they will notice that their baby begins to take milk more quickly a few minutes into the feed. When milk is expelled from the breast, some moms report feeling a tingling or prickling sensation, while others do not.
What is a let-down in breastfeeding?
When a newborn begins to suckle, a response that involves nerves and hormones (called a neurohormonal reflex) releases milk from the breast.
This occurs when the infant begins to suckle.
The milk ejection reflex (MER) is sometimes referred to as the ″let-down″ reflex due to the popular name given to this response.
When milk is expelled in a particularly rapid manner, the process is frequently referred to as a ″fast let-down″ or a ″overactive let-down.″
We recommend reading: Readers ask: What Does A Tooth Abscess Feel Like?
How does the let-down reflex affect breast milk supply?
Issues with breastfeeding might arise when the let-down reflex is difficult to control.
They have the potential to reduce the quantity of breast milk that you produce because, for example, if your kid is only able to extract a tiny amount of milk from each of your feedings, the amount of milk that is produced by your body will diminish.
4 There are several potential causes for a delay in the beginning of milk production after breastfeeding.
How do you know if you're having a let down?
Signs of Milk Let-Down
Tingling: You may feel like you have pins and needles in your breasts, or you may get a warm sensation
Leaking: It is possible for you to observe breast milk dripping or spraying out of the breast that your baby is not currently nursing on
Gulping: You may hear your infant gulping and swallowing milk
What is let down supposed to feel like?
When your infant first begins to nurse, the nerves in your breast will transmit signals to your milk ducts, which will cause them to release milk. This let-down response often occurs after your child has been sucking on the breast for around two minutes. This let-down reaction might be experienced by some women as a tingling or a warmth.
How do you trigger a let down?
10 Methods That Will Help You Relax While You're Pumping Iron
Double pump. It's possible that if you pump both breasts at the same time, you'll experience a higher amount of stimulation, which will make it easier to create a letdown.
Massage of the breasts
Consider your child in this regard.
Calming oneself down and visualizing
We recommend reading: What Does A-fib Feel Like?
Is letdown painful?
A prickling or tingling feeling, similar to that of pins and needles. Yes, it is possible for it to be distressingly intense, and it may even be painful. Some mothers only experience this during the first few days of nursing, after which it often disappears. Some people have feelings of depression throughout each and every breastfeed.
How much milk is in a let down?
The quantity of milk that is expelled with each milk ejection initially releases an average of one ounce, but this quantity gradually decreases as the feeding continues. A very small number of mothers have been observed to expel more than an ounce at the beginning of each feeding.
What does forceful letdown look like?
When babies are irritable at the breast and are gagging, choking, pushing off the breast, tugging the breast, coughing, or gasping, most mothers discover that they have a forceful letdown. It's possible for infants to suffer from uncomfortable and excessive gas, hiccups, and spitting up as well.
Why does letdown take so long at night?
Possible reasons for a gradual let-down in pace A sluggish or inhibited let-down can be brought on by a variety of factors, including but not limited to worry, pain, humiliation, stress, cold, excessive use of coffee, smoking, consumption of alcohol, or usage of certain drugs.
Women who have had breast surgery run the risk of having nerve damage, which can make it difficult for them to let their babies down.
How long does a letdown last?
On most pumps, the initial letdown cycle lasts two minutes. Pump for 6-7 minutes after that and then click the button to go through the letdown cycle again and pump for another 6-7 minutes.
We recommend reading: Why Does My Stomach Feel Like It's Flipping?
Can baby get milk without letdown?
You are still able to effectively breastfeed your child even if you do not have a let-down reaction, and pumping milk will not present any challenges for you. However, you could pick up on the following aspects of the let-down relex: A prickling feeling that can occur before, during, or after a meal.
Why do my breasts tingle between feedings?
The milk let-down sensation, also known as the ″milk ejection reflex,″ is frequently described as having the sensation of pins and needles or tingling across the breasts. However, for some, the sensation is felt deep within the breasts and can be painful or achy, particularly at times when milk production is at an all-time high.
What triggers milk let down?
When your infant suckles at the breast, he or she stimulates the minuscule nerves in the nipple.
The stimulation of these nerves results in the release of hormones into the circulation.
One of these hormones, called prolactin, works on the tissues that are responsible for milk production.
The other hormone, oxytocin, is what stimulates the breast to expel the milk, sometimes known as ″letting it down.″
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text:
Q: Scroll down automatically after clicking on CommandButton or we can say Pageblock refresh to a bottom of the page Hi I have lengthy custom form, wher user can select some field, when he submit the another page block except this list of fields refreshes and shows the list of batch classes at bottom of the page.
but when the user submits, the pageblock gets refreshed and it go to the top of the page , but i want that to scroll down to the bottom of the page automatically where my another pageblock resides.
i found the snippet of java script function which works fine on page load, but i want it to happen conditionally on button click.
<script>
function Scrolldown() {
window.scroll(0,500);
}
window.onload = Scrolldown;
</script>

below is my command button
  <apex:commandButton value="  Submit  " action="{!docSubmit}" onclick="return confirmSubmit()" />

i added the oncomplete to my button and called the js function it didnt work.
Or any suggestion where i can do this with my Visualforce - attributes/Label/Goto like concepts or with my apex code.

A: <apex:commandButton
    value="..."
    action="..."
    onclick="..."
    reRender="someAreaById"
    oncomplete="scrollSomewhere()" />

someAreaById should be the area to be refreshed; you can can give the form itself an Id and rerender the entire form. This is usually what I do if I can't readily determine which parts of the form may be affected. Other times, I can, and I rerender just a small part of the form. It will load much faster this way. scrollSomewhere() should be a function to write to scroll to a certain area. It could be window.scroll, or HTMLElement.scrollIntoView, which is supported on all modern browsers. You could query the element to scroll to by Id or some other attribute.
function scrollSomewhere() {
    document.querySelector('#someDiv').scrollIntoView();
}

If the element is a Visualforce element, the ID value will be modified, so you should use the $Component global variable to correctly identify the component, and you'll also need to escape the ":" with \3a for a proper match:
'#{!SUBSTITUTE($Component.form.block2.someElement,':','\\\\3a')}'

JavaScript requires \\ to represent a literal \, and the formula tool requires \\ to represent a literal \, so you end up double-escaping the \3a required by CSS.

redpajama_set_name: RedPajamaStackExchange


text:
NJ.com's All-Group 1 girls lacrosse selections, 2021
Updated: Jun. 29, 2021, 11:55 p.m. | Published: Jun. 29, 2021, 10:10 a.m.
McKenzie Blake (21) of Haddonfield pushes past Glen Ridge's Lily Kuhn (19) and Cooper Palm (21) during the NJSIAA Group 1 girls lacrosse championship between Haddonfield and Glen Ridge at Montgomery High School in Skillman, NJ on Saturday, June 12, 2021. Scott Faytok | For NJ Advance Media
By Brian Deakyne | NJ Advance Media for NJ.com and Evan Slavit | NJ Advance Media for NJ.com
ALL-GROUP 1 GIRLS LACROSSE TEAMS


text:
Guy Ogilvy
Guy Ogilvy studied languages at university and spent a lot of time behind the Berlin Wall in the late 70s/early 80s. Subsequent travels brought him into contact with ancient medicine and religious traditions in South America, the Himalayas and Ethiopia. He abandoned a promising career in publishing to pursue a personal quest that culminated in an 18-month stint as a cave-dwelling hermit in the mountains of Central North Mexico. He returned to England to study alchemy under the guidance of the Philosophers of Nature and Manfred Junius. He began writing on esoteric subjects to support his family and has written several of the books published under the name Francis Melville. His books have been translated into more than twenty languages and sold over 750,000 copies. He has appeared on several television networks in Britain, Japan and the USA to share his expertise on esotericism and alchemy. He lives near Glastonbury in Somerset, England with his wife, daughters and whippets. His favourite activities include foraging, laboratory alchemy and singing with country band The Johnsons.
By Guy Ogilvy
Santa's psychedelic history of Christmas
The true spirit of Yuletide is shaman, flying reindeer and magic mushrooms


Make homemade peach ice cream.
See a firework show-preferably after a Braves game.
Take a weekend trip to one of the cities in this book. I'm thinking Nashville.
Try oysters. Although, I don't think I could stomach it. It's a texture thing.
Go fishing. It's my boyfriend's favorite sport and I haven't been since my brother hooked my ear when we were kids.
Spend a day at the beach. That's a given.
Run in this colorful 5K.
Drink a Nitro Martini from Elevation Chophouse.
Celebrate my two year anniversary.
A few weeks back my boyfriend and I had plans to attend the Marietta Greek Festival, but bad weather put a damper on our plans. Literally! It rained all weekend and while we could have made an effort to attend, wet baklava just didn't seem appetizing. So, we headed to the next best location for Greek fare-the Marietta Diner. You may have seen this gem on the Food Network, the Marietta Diner specializes in homemade Greek food but also serves a variety of cuisines. The menu has everything from spanikopita and souvlaki to patty melts and omelets. After the complimentary spanikopita, I enjoyed warm matzo ball soup followed by the Chicken St. Marie, a chicken breast rubbed in oregano then sauteed in a lemon sauce. I was so stuffed from dinner that I didn't have any room for dessert, although the cheesecake selection looked amazing. If you are ever in Marietta, I highly recommend you give this place a try. We were able to get our fill of delicious Greek food and the best part-we didn't have to sit in the rain to do it!
This past weekend was definitely a relaxing one. I was able to soak up some much needed sun (it was 75 and sunny all weekend), finally got my car washed, and even took advantage of the Memorial Day sales. I got this tunic from J.Crew that I've been lusting over for quite a while and this Madewell sweater on super sale (SCORE)! However, my weekend mainly revolved around eating lots of delicious food. I attended several barbecues, baked a S'mores pie (recipe to follow), and made these Watermelon Mint Tequila popsicles. They were so refreshing after a long day at the pool. The weekend ended with a stroll through Marietta Square, where they had flag lined streets in honor of all the fallen soldiers. It was truly a reminder of what Memorial Day is really about. I am so thankful to all the brave men and women that serve or have served our country so that we may enjoy our everyday freedom. I am so blessed to live in this beautiful nation!
I've always been a fan of The Great Gatsby (I've read it over 14 times), so when I heard that Baz Luhrmann was remaking this classic, I had to see it. Last Tuesday, my boyfriend and I saw it for our usual date night and it exceeded my expectations! The storyline stayed true to the book, the cast was amazing (Leo has been a longtime crush), but more importantly, the costumes were exquisite. Intricate headpieces, elaborate beaded dresses, strings of pearls, and of course, the famous flapper dress were prominent throughout the film. Could 1920's fashion be more perfect? The main characters also flaunted an array of textures, including silk kimonos, neutral linen suits and elegant lace dresses. Wanting to incorporate some of this "Gatsby glam" into my everyday wardrobe, I've picked out some key pieces that blend the wonderfully deco style of the Jazz age with a more modern twist. My favorite piece from the movie was the printed head scarf Carey Mulligan's character wore while at Gatsby's mansion. I plan on emulating that same look this summer while lounging poolside.
One of the many perks about living in the South is that there is no shortage of barbecue. Last weekend, my boyfriend and I were craving some, so we headed over to Jim N' Nick's Bar-B-Q in Vinings for a dinner date. When we arrived, we were greeted with a warm basket of cheese and corn biscuits. They were absolutely delicious. We may or may not have had two baskets. I am still regretting not buying the mix to make them at home. After my biscuit indulgence, I enjoyed a plate of baby back ricks, baked beans and homestyle mac n' cheese. The ribs are smoked, basked in Jim N' Nick's signature barbecue sauce and served ready to be peeled off the bone. It's no secret that I love good barbecue. After my trip to Pigfest, I've been on the hunt for great barbecue in Atlanta. I highly recommend Jim N' Nick's. The atmosphere is casual, the service was excellent and our meal was incredible. I'm ready to go back for seconds.


text:
Q: Polkadot tx-wrapper offline signing What does ExtrinsicPayload exactly do? I want to replicate the logic but something is missing.
import {
    getRegistry
} from '@substrate/txwrapper-polkadot';

const registry = getRegistry({
        chainName: 'Polkadot',
        specName,
        specVersion,
        metadataRpc,
    });

const extrinsicPayload = registry.createType('ExtrinsicPayload', unsigned, {version: unsigned.version});
const extrinsicPayloadU8a = extrinsicPayload.toU8a({method: true})
const actualPayload = extrinsicPayloadU8a.length > 256 ? registry.hash(extrinsicPayloadU8a) : extrinsicPayloadU8a;

const s1 = u8aToHex(alice.sign(actualPayload));
console.log("s1", s1, s1.length);
const s2 = extrinsicPayload.sign(alice).signature;
console.log("s2", s2, s2.length);

s1 and s2 should have the same length but they don't. What's the reason?

A: You should pass {"withType": true} to the sign method too.
const s1 = u8aToHex(alice.sign(actualPayload, {"withType": true}));

sr25519 uses randomness for signing, so the results won't be the same, but they should have the same length.


Our latest Quest landed us at Nan Bei Ho in Bayside, Queens, New York. The owner Angela Mao was as famous as Bruce Lee, when she was a martial arts film star in Hong Kong during the 70's. We hoped to meet the living legend herself, and have a legendary meal. But alas, all we were met by was disappointment.
Our last Quest of the year was a rousing success. Accompanied by a very special guest, we dined at Main Street Imperial Taiwanese Gourmet Chinese restaurant. Check out our review!
So nu? Tonight we reviewed a Chinese restaurant in Flushing New York called OK Ryan. What was it? Ok? Yes, it was ok. Just not great by Flushing standards.
[REVIEW] LITTLE DUMPLING – A GOOD RESTAURANT THAT DOES NOT QUITE MEET THE MARK!
Here is an unbiased review of "Little Dumpling", and authentic Chinese restaurant that opened a few months ago in Little Neck, NY. We think you'll like it!