I can hardly believe it is really ten years since I ventured pole-wards with my good friend Chris to visit Tromso, which at 69.6 degrees is still the northernmost city in the world. Our short visit must have made such a deep impression on me that I found myself telling Grahame how wonderful it had been more often than was strictly necessary. All the same, when I first thought of taking him to the Arctic for a birthday present (a man can get so sick of socks and ties!) I had been exploring the possibility of a trip to Murmansk. Then a sudden downturn in our diplomatic relations with Russia put those plans on hold for the time being so Tromso it would have to be.
While the Gulf Stream continues to flow the summers up here in north Norway can be exceptionally mild but since we were leaving behind the enervating weather of a record-breaking heatwave we were none too disappointed to find it overcast and chilly on our arrival. In the event, we didn't see the midnight sun once throughout our whole week's stay and cloud cover also made it impractical for a repeat of the whale watching boat tour out through the neighbouring islands. Nonetheless, we certainly found plenty to do and, with the economies of AirBNB, a weekly bus ticket and regular trips to the supermarket for self-catered meals, we were able to enjoy ourselves without breaking the bank. Hot chocolate and slice of cake for two in a restaurant can cost upwards of £28 so it definitely pays to plan ahead.
We took a bus ride down to the University Museum at the southernmost tip of the island and had a look around the models explaining the aurora borealis, various dioramas demonstrating examples of arctic wildlife (stuffed) and a number of rooms containing displays of various Sami costumes and artefacts. Without adequate explanation, the latter seemed rather disappointing and I caught myself hanging onto the tail end of a cruise ship guided tour to try to listen in for any useful snippets of information. However, in the manner of cruise ship groups the world over, this one passed through the gallery at whirlwind speed and so, coupled with the fact that my eavesdropping was hindered by a limited understanding of Italian, this turned out to be a pretty fruitless exercise.
But help was at hand when we found our way outside to the "living exhibit" of a rather pissed-off student wearing full ethnic regalia and tending the fire in an authentic sod-covered hut. We were able to overcome her initial hostility with a few more intelligent questions and less patronising observations and she offered to arrange a proper guided tour of the exhibits for us if we were prepared to come back on the following day. It wasn't hard to feel for the girl, probably an anthropology undergraduate or some such, having to cope with inanities of a new batch of tourists arriving every day of the summer season to "do the Arctic" in a day and a half.
The Sami reindeer herders have eight seasons in their calendar and midsummer is a busy time when visitors are not welcome out on the pastures so we could not go for a visit ourselves. However, back at the museum on the next day the culture came to us in the person of another, altogether more enthusiastic, student who went to the trouble of bringing a bag of her own personal treasures to enliven her tour. The intricacies of duodji (wood, bone and antler tools which are often highly decorated but always completely utilitarian) and the practicalities of traditional clothing so came to life with her vivid explanations that our half hour tour stretched out to take up much of the afternoon.
Only about 10% of Sami people live by reindeer herding although up here in the Northern region the proportion is considerably higher. Fishing, farming and other less nomadic livelihoods have been the mainstay of these indigenous Arctic people for thousands of years but they have never been reticent in adopting innovation and some of the traditions most beloved by visiting tourists are quite recent imports. I particularly love the story of the consignment of bright blue woollen cloth intended for French naval uniforms which found its way North by accident some time during the early nineteenth century. I had long suspected that the brilliant shade of scarlet used in Sami accessories was not the product of roots and berries alone but now I at least know where the blue comes from.
Nor is much traditional Sami music of any long standing. The sacred drum was used in ceremony without the addition of other instruments and the adding of song lyrics and musical accompaniment to the joik (a high-pitched animal herding cry) has only been around since it became famous on TV by a few handsome heartthrobs who made it big in the 1960s. Later, I rather regretted asking how they got the hair off of the reindeer skins to make the finest bags and shoes that no self-respecting Sami woman can be without. The time-honoured method seem to have involved burying the hides under the floorboards or leaving them to soak in a freezing lake but apparently nowadays you just wrap them in some plastic bags "until they really stink". We were told that each girl learns to make her own accessories (or at least those who are as talented as our guide) but even she had to revert to conventional stuffing for her slippers when the other students complained about dried grass getting all over the place.
The bus tickets enabled us to get around as much as we liked and over the next few days and we took in the Polar Museum (which more than lived up to expectation) and the Polaria Arctic aquarium (which did not). The University Botanical Gardens were an experience to be treasured even if one is not a keen horticulturalist (and I'm not) and seeing these exquisitely delicate plants in flower more than made up for any disappointments on the cetacean front. There are specimens from other extreme environments all around the world: treasures from Svalbard, Patagonia and the Himalayas, some so rare that there are still only a few individuals known to science. It was a special privilege to be able to wander around them at liberty (and for free) with just a few polite reminders not to leave the path. And there were waffles with fresh cloudberries for sale in the cafeteria.
This time we didn't bother with the Arctic cathedral as I've discovered since my last visit that it is actually only a church and the real cathedral, the Domkirk, was closed for renovations. We did, however, take the cable car up to the viewing platform on the top of the opposite islands and our view out over the fjords helped to set the bleak, rocky landscape in perspective. And to confirm that a boat trip would have been a bad idea. We decided against trying out the "Midgard" takeaway pizza restaurant and found the doors of the "Ragnarok" cafe and burger bar firmly closed but, despite these lapses in good taste the city displayed less of the anomalous Viking paraphernalia than one finds in many other Scandinavian destinations.
Altogether more charming was the way in which local women feel comfortable to adopt traditional Norwegian folk costume for special occasions such as a Saturday night restaurant visit and the flattering combination of bold felt waistcoats, embroidered lace blouses and shimmering silver jewellery was not an unusual sight. If you want the full-on Nordic fantasy, nonetheless, you could not do better than to visit the Tromso Bruktbokhandel: without a doubt the best sword wielding, dragon-slaying fantasy comic book and DVD emporium within the Arctic Circle. The proprietor was away when we popped in to replenish our reading material but his teenaged son came to my rescue when I got lost among the labyrinthine shelves of doorstop sized sagas and trilogies, quadrilogies or whatever. Not the worst way to spend an Arctic Winter, I suppose.
On our last day we climbed to the natural lake which has been extended to form a huge reservoir and paradise for visiting sea birds. These are not so easy to photograph as the flowers but we saw an otter, terns and cormorants and some (probably) rare varieties of duck while we had a very enjoyable bit of exercise without risking getting lost on a proper hike. The greater black-back gull is enormous and pretty intimidating close up and, when we got to the other side of the lake we found out why some of the birds had got so tame. Here an elderly, Chinese gentleman with a straggly beard was carefully fending off the larger birds to feed a few of his favourites. Smallish, with black feathers and yellow rimmed eyes: they definitely weren't ravens but otherwise don't ask me what they were. We started a conversation and he shyly invited us to partake at his restaurant down in the town but when I asked who he was he replied enigmatically "I have many names". He wasn't wearing a cloak or an eyepatch but I did find myself checking whether or not it was a Wednesday.


text:
Q: Why does  height change when I change a heading to display: inline? I have the following:

Hello

Hello

Hello

h4 {
    font: normal 12px/23px Arial, sans-serif; margin: 0; padding: 0 7px;
    border: 1px solid #CCC; background-color: red;
}
h4.a { display: inline; }
h4.b { display: inline; height: 23px; }

Example: Here
What I need is for the height of the heading to remain the same but for the width to not be full width. I changed to inline but I notice that now the height changes. Can someone explain how I can keep it the same height?

A: You quite simply can't apply an explicit height value to an element with display: inline.
What if you made it display: inline-block instead?

A: I'd be more inclined to use float: left

redpajama_set_name: RedPajamaStackExchange


Newton Hotel has been established since 1964 and was taken over in 2006. Since being taken over it has been fully refurbished to offer our guests a very high standard of accommodation.
We are a small Bed & Breakfast hotel allowing us to ensure that our guests always receive the best service and hospitality during their stay at the hotel, we really do provide a truly personal service.
All our rooms include en-suite showers and guests have the choice of a single, double and family room options. We also have a room specifically catered for disabled guests.


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Home > Technology Frontiers > Blockchain based Technologies
Blockchain has been heralded as the most significant innovation since the Internet itself. It initially emerged as the backbone of bitcoin and is an incorruptible digital public ledger of transactions. Blockchain technology is a novel data structure that is secure, cryptography-based, and stores transactional records (known as the block) in databases (known as chains) distributed across a network through peer-to-peer nodes, allowing the transfer of digital goods. It works on the principles of transparency, decentralisation, accountability, and immutability. They find wide applications in Smart contracts, Supply chain management, Asset protection through an indisputable record of real-time ownership, Personal data management and Identification, Payment processing, Crowdfunding through cryptocurrencies, tracking drugs in pharmaceutical supply chains, verification of land records and certificates, etc. The potential of blockchain technology to enable remote voting is also being explored by the election commission. It is estimated that blockchain will generate $3.1 trillion worldwide in new business by 2030. India aims to become a digital economy powerhouse and embracing emerging technologies like cryptocurrency and blockchain is a necessity. The digital economy currently comprises 14-15% of India's total economy, which is targeted to reach 20% by 2024.
Globally India is among the fastest-growing FinTech markets. It is expected that 60% of retail and SME credit will be digitally disbursed by 2029. In 2019, fintech investments nearly doubled to $3.7 billion from the previous year's $1.9 billion. The Indian fintech ecosystem is the third-largest in the world and attracted investments of nearly $6 billion since 2014. Digital payments are expected to touch $500 billion by 2020, about 15% of the GDP. The International Financial Services Centres Authority (IFSCA) introduced a framework of "Regulatory Sandbox" for entities operating in the capital market, banking, insurance, and financial services to experiment with innovative FinTech solutions and operates within the IFSC located at GIFT City (Gandhinagar). The Centre of Excellence (CoE) in Blockchain Technology was launched in Bengaluru for identifying and sharing suitable data and rendering world-class blockchain services to government departments. It is set up by the National Informatics Centre (NIC) to provide Blockchain-as-a-Service (BaaS) as a third-party cloud-based infrastructure and management. Institute for Development and Research in Banking Technology (IDRBT), an arm of the Reserve Bank of India (RBI), is working on a model platform for blockchain technology.
worth Blockchain ecosystem in India
of the states in India are involved in Blockchain-related initiatives
Blockchain initiatives are being executed by the public sector in India
Demand for blockchain talent is growing every quarter
NASSCOM Avasant India Blockchain Report 2019
Participating countries for standardization of Blockchain Technologies
India is among the 44 participating member countries for standardization of blockchain technologies and distributed ledger technologies in the International Organization for Standardization.
Evolving a National Strategy
NITI Aayog prepared Blockchain the India Strategy: Towards enabling ease of business, ease of living and ease of governance.
Initiatives by Other Departments
MoC launched Coffee Board Activates Blockchain-based Marketplace in India.
Ministry of Electronics & IT
National Informatics Centre (NIC) has set up the Centre of Excellence (CoE) in Blockchain Technology in Bengaluru, Karnataka.
NITI Aayog & GNFC
NITI Aayog and Gujarat Narmada Valley Fertilizers & Chemicals Limited (GNFC) -NITI Aayog partners with GNFC Ltd to implement Fertilizer Subsidy Disbursement through Block ...
Advancing Blockchain Technologies
Govt.of Telangana
Blockchain district, anchored by the Government of Telangana, brings together different facets of the Blockchain technology realm in the city of Hyderabad.
Govt. of Kerala
Kerala Blockchain Academy (KBA), is an initiative of the Government of Kerala under the IIIT– Kerala, for offering blockchain training in multiple domains.
Govt. of Andhra Pradesh
The government of Andhra Pradesh is working with Zebi data for blockchain-based solutions in land registry. The government is also partnering with Hitachi to set up an online citizen governance platform.
The Telangana government has signed a MoU with Tech Mahindra and is collaborating with IIIT Hyderabad and C-DAC to build a state-level Blockchain platform. It is also collaborating with NITI Aayog for blockchain in governance.
The Maharashtra government has signed an MoU with the Swiss government to share ideas on Blockchain technology and its applications.
Govt. of Tamil Nadu
The Tamil Nadu government has signed a MoU with IIT Chennai to explore Blockchain applicability in different use cases.
Govt. of Assam
The Assam government is collaborating with Nucleus Vision to set up Blockchain solutions for governance process and other citizen-facing applications.
Govt. of Uttar Pradesh
The Uttar Pradesh government has partnered with UNDP to implement a Blockchain solution in land title management.
Govt. of Gujarat
Gujarat government was collaborating with Zebpay to explore blockchain technology applications in the state.
Govt. of Rajasthan
The Rajasthan government has partnered with Mumbai-based Auxesis group to implement a Blockchain solution in electronic health records and land registration.
Blockchain based Technologies News & Updates from India
Blockchain-based Technology
The subdued rise of blockchain in India
by The Hindu
Abjayon partners with ISGF on pilot project into solar power power using blockchain technology
by Times of India
Blockchain smart phone launched in the country
by United News of India
Uttar Pradesh Starts India's First Blockchain-Enabled Rooftop Solar Trading Platform
by Rahul Nair
Indian Crypto Boom: New Traders Flood Exchanges — CEOs Reveal What's Driving Massive Growth
by News Bitcoin
Blockchain platform connects Indian farmers to UAE food industry
by Turner Wright
Indian state of Tamil Nadu announces blockchain infrastructure plan
by Husayn Hashim
Top Indian Startups In The Field Of Blockchain Technology
by Vishal Chawla
Blockchain based Technologies News & Updates from across the world
Colombian Financial Watchdog Says Local Firms Can Use Capital to Buy Bitcoin
Singapore tightens rules for virtual payment service providers offering crypto
The UK's ban on crypto derivatives is set to go into effect on Wednesday
Chilean Court Orders Two Major Banks to Keep Open Checking Accounts of Crypto Exchange Buda
Kyrgyzstan Central Bank Is Set to Introduce Bills to Monitor Crypto Exchanges Activities and Forcing Them to Apply for Permits
Story from Tech Blockchain Platform Telos Launches Crypto Tokens That Act Like Treasurys
Lead Agencies
Top Organisations / Institutions In India

redpajama_set_name: RedPajamaCommonCrawl


If you have seen any of my social media pages recently you may have realised that last week we were at Bluestone in Wales!
When an email landed in my inbox a few months ago inviting us along for a stay I couldn't contain my excitement. The place looked amazing online and I knew the kids would love it, well last week the time finally come for us to visit so we packed up our car and off we went.
Upon arriving we came up to the check in point for Bluestone which thanks to their "drive thru" style check in was super quick and really easy. Its just a case of driving up to the indicated window and handing over either your booking reference number or surname and you are handed your welcome pack and keys and shown where your lodge is!
As we were in a Ramsey lodge we could check in from 3pm and had very little time to wait so we parked up for a little bit and checked out the map we had received in our welcome pack. In no time 3pm had arrived and we were shown through the gate and off we went to find our lodge. We had been given a map which our accommodation had been circled on but everything is so well sign posted at Bluestone finding our lodge was really easy to find.
Our lodge was beautiful and you can read more about our Bluestone accommodation here.
Bluestone is a no car zone (with exception to check in and check out days where cars are allowed back on site), however you can hire bikes or golf buggies to get around whilst you are there. We had been undecided at home about hiring one as we weren't sure how far away our lodge would be from the amenities. We soon discovered we were quite a walk away and opted to hire a golf buggy on our second day.
We were really lucky and the buggy hire centre had a buggy for us however Bluestone do advise that you book these before arrival, there is no guarantee there will be any left if you wait until you arrive on site. The cost for buggy hire is £92 for the week (with bikes averaging about the same for a family of 4). I did think this was a little steep but after a day of walking up the hills with a non compliant toddler it was certainly worth it for us.
There is so much to see at Bluestone I would suggest setting aside a few hours to explore each day, there are mapped out walks as well as the village, lots of parks, the lake and the steep ravine to name a few. You will also receive a timetable when you check in which will list and detail all the Bluestone activities on offer during your stay with times, dates and prices. There was something for everyone from baby sensory and messy play to tree climbing, high ropes and even little excursions little ones can go on without parents. James really wanted to take part but lots of the "older kids" activities were 8 + and as he is only 7 was unable to join in. I know when we next return he will have a whole host of activities on his list to do!
There are also plenty of places to eat on site at Bluestone from the Chippy to serving your classic fish and chips to Camp Smokey where you can dine al fresco on food cooked on the open fired barbecue! We did grab some chips from the Chippy after our day at Folly Farm and they were delicious and the prices were really good too.
The smell coming from the Farmhouse Grill was amazing (and they apparently have a children's play area to keep the kids entertained whilst you wait too!) Unfortunately we didn't eat out at any of the restaurants this time as Evelyn was so tired on an evening from all our exploring but we will definitely be trying them out next time we visit.
The Blue Lagoon and Adventure centre were big hits with both James and Evelyn too, with the adventure centre evening featuring a LEGO wall, HUGE soft play centre and even a 9 hole game of crazy golf. With usage of all these things included in your holiday cost! Despite lots of the lodges seeming occupied none of the amenities seemed overly busy which was great. Bluestone never felt cramped or busy at any point which was a big plus for me and a credit to how well Bluestone is organised.
The Blue Lagoon is fantastic and we managed to squeeze in 2 visits here as it was such a hit with the kids. There is a wave machine, lazy river and as well as the main pool there are 2 smaller pools with a beach/pirate theme perfect for younger kids! Evelyn loves all the fountains and spouts in these she could play with. James loved the 3 water slides on offer in the lagoon and was thrilled to discover he was tall enough for them all! The swimming pool is actively watched by vigilant lifeguards who were doing a great job, the slides were watched by lifeguards too which meant they ran really smoothly and safely at all times.
All the staff we met at Bluestone were fantastic, there really is nothing that is to much trouble and from what we saw they all went out of their way to ensure everyone on site has the most amazing time. We had a little issue with out buggy giving up on us at one point and the staff were straight out to our lodge to try to fix/replace it. The staff we met were always smiling and took the time to engage with the kids which of course Evelyn loved as she is such a chatter box.
Whether its the thrill of the high ropes, the adventure of the nature trails or the relaxation of the spa Bluestone has it covered. The park itself is has a friendly village atmosphere that instantly makes you want to smile and relax, which is exactly what holidays should do right?
Leaving Bluestone left us all emotional, we may have only been there for 5 days but it already felt like home. Bluestone gave us quality family time with freedom, fresh air and memories that we will remember forever. I know that we will be returning, we couldn't not return its been so special for us. Its the kind of place that I hope my kids will bring their kids in years to come and relive all the amazing memories we are making right now!
If you have been thinking about booking a Bluestone break, do it! You won't regret it, its almost impossible to regret visiting somewhere so beautiful and there really is something for everyone.
We love Bluestone Wales and have stayed there many times. The blue lagoon is amazing for families!
that looks like a really fun place to visit, love the indoor play area.
Great review lovely. We felt really emotional leaving Bluestone too! Such a lovely and relaxing place.
It sounds like an incredible getaway, the Blue Lagoon looks like so much fun! Love the idea of the drive thru check-in, too!!
It always looks such a wonderful place, the setting is idyllic.


Shaw Yoga's founders bring to Shaw Yoga's mission decades of personal and professional dedication.
Ben's passion for entrepreneurship, self-reliance, and the potential for local businesses to effect change prepared him to help shape the mission of Shaw Yoga. A lawyer by training, his sense of fairness, attention to detail, and fondness for adventure led him away from the legal desk and into the creative world.


Fisher & Paykel is doing freestanding cookers now and we're redecorating!
Cleaning your oven racks could easily top the list of kitchen jobs that rarely get done.
But according to Melissa Maker, the cleaning expert behind popular YouTube channel Clean My Space, after watching her video, 80 per cent of people will want to clean their oven racks.
The hack is simple but does require soaking the racks overnight.
Watch the full video below for Melissa's step-by-step instructions.


GIWA Co-Founder, Pujya Swami Chidanand Saraswati and Secretary General, Sadhvi Bhagawati Saraswati met South Africa's President, His Excellency, Mr. Jacob Zuma, at a private meeting yesterday, at the Johannesburg home of Shri Ajay Guptaji. During the meeting, they discussed the mission of GIWA and the importance of WASH for everyone, everywhere. The meeting ended on a warm note, with the President's pledge to arrange for meetings with his Cabinet ministers upon their return to South Africa.


text:
Genome and Epigenome
Genetic Data from Nearly 63,000 Women of European Descent Predicts DNA Methylation Biomarkers and Epithelial Ovarian Cancer Risk
Yaohua Yang, Lang Wu, Xiang Shu, Yingchang Lu, Xiao-Ou Shu, Qiuyin Cai, Alicia Beeghly-Fadiel, Bingshan Li, Fei Ye, Andrew Berchuck, Hoda Anton-Culver, Susana Banerjee, Javier Benitez, Line Bjørge, James D. Brenton, Ralf Butzow, Ian G. Campbell, Jenny Chang-Claude, Kexin Chen, Linda S. Cook, Daniel W. Cramer, Anna deFazio, Joe Dennis, Jennifer A. Doherty, Thilo Dörk, Diana M. Eccles, Digna Velez Edwards, Peter A. Fasching, Renée T. Fortner, Simon A. Gayther, Graham G. Giles, Rosalind M. Glasspool, Ellen L. Goode, Marc T. Goodman, Jacek Gronwald, Holly R. Harris, Florian Heitz, Michelle A. Hildebrandt, Estrid Høgdall, Claus K. Høgdall, David G. Huntsman, Siddhartha P. Kar, Beth Y. Karlan, Linda E. Kelemen, Lambertus A. Kiemeney, Susanne K. Kjaer, Anita Koushik, Diether Lambrechts, Nhu D. Le, Douglas A. Levine, Leon F. Massuger, Keitaro Matsuo, Taymaa May, Iain A. McNeish, Usha Menon, Francesmary Modugno, Alvaro N. Monteiro, Patricia G. Moorman, Kirsten B. Moysich, Roberta B. Ness, Heli Nevanlinna, Håkan Olsson, N. Charlotte Onland-Moret, Sue K. Park, James Paul, Celeste L. Pearce, Tanja Pejovic, Catherine M. Phelan, Malcolm C. Pike, Susan J. Ramus, Elio Riboli, Cristina Rodriguez-Antona, Isabelle Romieu, Dale P. Sandler, Joellen M. Schildkraut, Veronica W. Setiawan, Kang Shan, Nadeem Siddiqui, Weiva Sieh, Meir J. Stampfer, Rebecca Sutphen, Anthony J. Swerdlow, Lukasz M. Szafron, Soo Hwang Teo, Shelley S. Tworoger, Jonathan P. Tyrer, Penelope M. Webb, Nicolas Wentzensen, Emily White, Walter C. Willett, Alicja Wolk, Yin Ling Woo, Anna H. Wu, Li Yan, Drakoulis Yannoukakos, Georgia Chenevix-Trench, Thomas A. Sellers, Paul D.P. Pharoah, Wei Zheng and Jirong Long
Yaohua Yang
Division of Epidemiology, Department of Medicine, Vanderbilt Epidemiology Center, Vanderbilt-Ingram Cancer Center, Vanderbilt University Medical Center, Nashville, Tennessee.
Lang Wu
Xiang Shu
ORCID record for Xiang Shu
Yingchang Lu
Xiao-Ou Shu
ORCID record for Xiao-Ou Shu
Qiuyin Cai
Alicia Beeghly-Fadiel
Bingshan Li
Department of Molecular Physiology & Biophysics, Vanderbilt Genetics Institute, Vanderbilt University, Nashville, Tennessee.
Fei Ye
Division of Cancer Biostatistics, Department of Biostatistics, Vanderbilt University Medical Center, Nashville, Tennessee.
Andrew Berchuck
Department of Obstetrics and Gynecology, Duke University Medical Center, Durham, North Carolina.
Hoda Anton-Culver
Department of Epidemiology, Genetic Epidemiology Research Institute, University of California Irvine, Irvine, California.
Susana Banerjee
Gynaecology Unit, Royal Marsden Hospital, London, United Kingdom.
Javier Benitez
Human Cancer Genetics Programme, Spanish National Cancer Research Centre (CNIO), Madrid, Spain.Biomedical Network on Rare Diseases (CIBERER), Madrid, Spain.
Line Bjørge
Department of Gynecology and Obstetrics, Haukeland University Hospital, Bergen, Norway.Center for Cancer Biomarkers CCBIO, Department of Clinical Science, University of Bergen, Bergen, Norway.
James D. Brenton
Cancer Research UK Cambridge Institute, University of Cambridge, Cambridge, United Kingdom.
ORCID record for James D. Brenton
Ralf Butzow
Department of Pathology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
Ian G. Campbell
Peter MacCallum Cancer Center, Melbourne, Victoria, Australia.Sir Peter MacCallum Department of Oncology, The University of Melbourne, Melbourne, Victoria, Australia.
Jenny Chang-Claude
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.Cancer Epidemiology Group, University Cancer Center Hamburg (UCCH), University Medical Center Hamburg-Eppendorf, Hamburg, Germany.
ORCID record for Jenny Chang-Claude
Kexin Chen
Department of Epidemiology, Tianjin Medical University Cancer Institute and Hospital, Tianjin, China.
Linda S. Cook
University of New Mexico Health Sciences Center, University of New Mexico, Albuquerque, New Mexico.Department of Cancer Epidemiology and Prevention Research, Alberta Health Services, Calgary, Alberta, Canada.
Daniel W. Cramer
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Obstetrics and Gynecology Epidemiology Center, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Anna deFazio
Centre for Cancer Research, The Westmead Institute for Medical Research, The University of Sydney, Sydney, New South Wales, Australia.Department of Gynaecological Oncology, Westmead Hospital, Sydney, New South Wales, Australia.
ORCID record for Anna deFazio
Joe Dennis
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.
ORCID record for Joe Dennis
Jennifer A. Doherty
Huntsman Cancer Institute, Department of Population Health Sciences, University of Utah, Salt Lake City, Utah.
Thilo Dörk
Gynaecology Research Unit, Hannover Medical School, Hannover, Germany.
Diana M. Eccles
Cancer Sciences Academic Unit, Faculty of Medicine, University of Southampton, Southampton, United Kingdom.
Digna Velez Edwards
Vanderbilt Epidemiology Center, Vanderbilt Genetics Institute, Department of Obstetrics and Gynecology, Vanderbilt University Medical Center, Nashville, Tennessee.
Peter A. Fasching
David Geffen School of Medicine, Department of Medicine Division of Hematology and Oncology, University of California at Los Angeles, Los Angeles, California.Department of Gynecology and Obstetrics, Comprehensive Cancer Center ER-EMN, University Hospital Erlangen, Friedrich-Alexander-University Erlangen-Nuremberg, Erlangen, Germany.
ORCID record for Peter A. Fasching
Renée T. Fortner
Division of Cancer Epidemiology, German Cancer Research Center (DKFZ), Heidelberg, Germany.
ORCID record for Renée T. Fortner
Simon A. Gayther
The Center for Bioinformatics and Functional Genomics at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Graham G. Giles
Cancer Epidemiology & Intelligence Division, Cancer Council Victoria, Melbourne, Victoria, Australia.Centre for Epidemiology and Biostatistics, Melbourne School of Population and Global Health, The University of Melbourne, Melbourne, Victoria, Australia.Department of Epidemiology and Preventive Medicine, Monash University, Melbourne, Victoria, Australia.
ORCID record for Graham G. Giles
Rosalind M. Glasspool
The Beatson West of Scotland Cancer Centre, Glasgow, United Kingdom.
Ellen L. Goode
Department of Health Science Research, Division of Epidemiology, Mayo Clinic, Rochester, Minnesota.
Marc T. Goodman
Samuel Oschin Comprehensive Cancer Institute, Cancer Prevention and Genetics Program, Cedars-Sinai Medical Center, Los Angeles, California.
Jacek Gronwald
Department of Genetics and Pathology, Pomeranian Medical University, Szczecin, Poland.
Holly R. Harris
Program in Epidemiology, Division of Public Health Sciences, Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington, Seattle, Washington.
ORCID record for Holly R. Harris
Florian Heitz
Department of Gynecology and Gynecologic Oncology, Dr. Horst Schmidt Kliniken Wiesbaden, Wiesbaden, Germany.Department of Gynecology and Gynecologic Oncology, Kliniken Essen-Mitte/Evang. Huyssens-Stiftung/Knappschaft GmbH, Essen, Germany.
Michelle A. Hildebrandt
Department of Epidemiology, University of Texas MD Anderson Cancer Center, Houston, Texas.
Estrid Høgdall
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.Molecular Unit, Department of Pathology, Herlev Hospital, University of Copenhagen, Copenhagen, Denmark.
Claus K. Høgdall
The Juliane Marie Centre, Department of Gynecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
David G. Huntsman
Department of Molecular Oncology, BC Cancer Research Centre, Vancouver, British Columbia, Canada.Department of Pathology and Laboratory Medicine, University of British Columbia, Vancouver, British Columbia, Canada.Department of Obstetrics and Gynecology, University of British Columbia, Vancouver, British Columbia, Canada.OVCARE, Vancouver Coastal Health Research Centre, Vancouver General Hospital and University of British Columbia, Vancouver, British Columbia, Canada.
Siddhartha P. Kar
Beth Y. Karlan
Women's Cancer Program at the Samuel Oschin Comprehensive Cancer Institute, Cedars-Sinai Medical Center, Los Angeles, California.
Linda E. Kelemen
Hollings Cancer Center and Department of Public Health Sciences, Medical University of South Carolina, Charleston, South Carolina.
Lambertus A. Kiemeney
Radboud Institute for Health Sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
ORCID record for Lambertus A. Kiemeney
Susanne K. Kjaer
Department of Virus, Lifestyle and Genes, Danish Cancer Society Research Center, Copenhagen, Denmark.Department of Gynaecology, Rigshospitalet, University of Copenhagen, Copenhagen, Denmark.
ORCID record for Susanne K. Kjaer
Anita Koushik
CHUM Research Centre (CRCHUM) and Département de Médicine Sociale et Préventive, Université de Montréal, Montréal, Quebec, Canada.
ORCID record for Anita Koushik
Diether Lambrechts
VIB Center for Cancer Biology, VIB and Laboratory for Translational Genetics, Department of Human Genetics, University of Leuven, Leuven, Belgium.
Nhu D. Le
Cancer Control Research, BC Cancer Agency, Vancouver, British Columbia, Canada.
Douglas A. Levine
Gynecology Service, Department of Surgery, Memorial Sloan Kettering Cancer Center, New York, New York.Gynecologic Oncology, Laura and Isaac Pearlmutter Cancer Center, NYU Langone Medical Center, New York, New York.
Leon F. Massuger
Department of Gynaecology, Radboud Institute for Molecular Life sciences, Radboud University Medical Center, Nijmegen, the Netherlands.
Keitaro Matsuo
Division of Molecular Medicine, Aichi Cancer Center Research Institute, Nagoya, Japan.Department of Epidemiology, Nagoya University Graduate School of Medicine, Nagoya, Japan.
Taymaa May
Division of Gynecologic Oncology, University Health Network, Princess Margaret Hospital, Toronto, Ontario, Canada.
Iain A. McNeish
Department Surgery & Cancer, Imperial College London, London, United Kingdom.Institute of Cancer Sciences, University of Glasgow, Wolfson Wohl Cancer Research Centre, Beatson Institute for Cancer Research, Glasgow, United Kingdom.
ORCID record for Iain A. McNeish
Usha Menon
MRC Clinical Trials Unit at UCL, Institute of Clinical Trials & Methodology, University College London, London, United Kingdom.
ORCID record for Usha Menon
Francesmary Modugno
Womens Cancer Research Center, Magee-Womens Research Institute and Hillman Cancer Center, Pittsburgh, Pennsylvania.Division of Gynecologic Oncology, Department of Obstetrics, Gynecology and Reproductive Sciences, University of Pittsburgh School of Medicine, Pittsburgh, Pennsylvania.
Alvaro N. Monteiro
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.
ORCID record for Alvaro N. Monteiro
Patricia G. Moorman
Department of Community and Family Medicine, Duke University Medical Center, Durham, North Carolina.
Kirsten B. Moysich
Division of Cancer Prevention and Control, Roswell Park Cancer Institute, Buffalo, New York.
Roberta B. Ness
School of Public Health, University of Texas Health Science Center at Houston (UTHealth), Houston, Texas.
Heli Nevanlinna
Department of Obstetrics and Gynecology, Helsinki University Hospital, University of Helsinki, Helsinki, Finland.
ORCID record for Heli Nevanlinna
Håkan Olsson
Department of Cancer Epidemiology, Clinical Sciences, Lund University, Lund, Sweden.
N. Charlotte Onland-Moret
Julius Center for Health Sciences and Primary Care, University Utrecht, UMC Utrecht, Utrecht, the Netherlands.
Sue K. Park
Department of Preventive Medicine, Seoul National University College of Medicine, Seoul, Korea.Department of Biomedical Sciences, Seoul National University Graduate School, Seoul, Korea.Cancer Research Institute, Seoul National University, Seoul, Korea.
ORCID record for Sue K. Park
James Paul
ORCID record for James Paul
Celeste L. Pearce
Department of Epidemiology, University of Michigan School of Public Health, Ann Arbor, Michigan.Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.
Tanja Pejovic
Department of Obstetrics and Gynecology, Oregon Health & Science University, Portland, Oregon.Knight Cancer Institute, Oregon Health & Science University, Portland, Oregon.
Catherine M. Phelan
Malcolm C. Pike
Department of Preventive Medicine, Keck School of Medicine, University of Southern California Norris Comprehensive Cancer Center, Los Angeles, California.Department of Epidemiology and Biostatistics, Memorial Sloan-Kettering Cancer Center, New York, New York.
Susan J. Ramus
School of Women's and Children's Health, Faculty of Medicine, University of New South Wales Sydney, Sydney, New South Wales, Australia.The Kinghorn Cancer Centre, Garvan Institute of Medical Research, Sydney, New South Wales, Australia.
ORCID record for Susan J. Ramus
Elio Riboli
Imperial College London, London, United Kingdom.
Cristina Rodriguez-Antona
ORCID record for Cristina Rodriguez-Antona
Isabelle Romieu
Nutrition and Metabolism Section, International Agency for Research on Cancer (IARC-WHO), Lyon, France.
Dale P. Sandler
Epidemiology Branch, National Institute of Environmental Health Sciences, NIH, Research Triangle Park, North Carolina.
ORCID record for Dale P. Sandler
Joellen M. Schildkraut
Department of Public Health Sciences, University of Virginia, Charlottesville, Virginia.
Veronica W. Setiawan
Department of Preventive Medicine, Keck School of Medicine, University of Southern California, Los Angeles, California.
Kang Shan
Department of Obstetrics and Gynaecology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
Department of Gynaecological Oncology, Glasgow Royal Infirmary, Glasgow, United Kingdom.
Weiva Sieh
Department of Genetics and Genomic Sciences, Icahn School of Medicine at Mount Sinai, New York, New York.Department of Health Science and Policy, Icahn School of Medicine at Mount Sinai, New York, New York.
Meir J. Stampfer
Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.
Rebecca Sutphen
Epidemiology Center, College of Medicine, University of South Florida, Tampa, Florida.
Anthony J. Swerdlow
Division of Genetics and Epidemiology, The Institute of Cancer Research, London, United Kingdom.Division of Breast Cancer Research, The Institute of Cancer Research, London, United Kingdom.
Lukasz M. Szafron
Department of Immunology, Maria Sklodowska-Curie Institute - Oncology Center, Warsaw, Poland.
ORCID record for Lukasz M. Szafron
Soo Hwang Teo
Cancer Research Malaysia, Subang Jaya, Selangor, Malaysia.Breast Cancer Research Unit, Cancer Research Institute, University Malaya Medical Centre, Kuala Lumpur, Malaysia.
ORCID record for Soo Hwang Teo
Shelley S. Tworoger
Department of Cancer Epidemiology, Moffitt Cancer Center, Tampa, Florida.Research Institute and Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
ORCID record for Shelley S. Tworoger
Jonathan P. Tyrer
Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Penelope M. Webb
Population Health Department, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
ORCID record for Penelope M. Webb
Nicolas Wentzensen
Division of Cancer Epidemiology and Genetics, National Cancer Institute, Bethesda, Maryland.
Fred Hutchinson Cancer Research Center, Seattle, Washington.Department of Epidemiology, University of Washington, Seattle, Washington.
Walter C. Willett
Department of Epidemiology, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.Channing Division of Network Medicine, Brigham and Women's Hospital and Harvard Medical School, Boston, Massachusetts.Department of Nutrition, Harvard T.H. Chan School of Public Health, Boston, Massachusetts.
Alicja Wolk
Institute of Environmental Medicine, Karolinska Institutet, Stockholm, Sweden.Department of Surgical Sciences, Uppsala University, Uppsala, Sweden.
ORCID record for Alicja Wolk
Yin Ling Woo
Department of Obstetrics and Gynaecology, University Malaya Medical Centre, University Malaya, Kuala Lumpur, Malaysia.
Anna H. Wu
Li Yan
Department of Molecular Biology, Hebei Medical University, Fourth Hospital, Shijiazhuang, China.
Drakoulis Yannoukakos
Molecular Diagnostics Laboratory, INRASTES, National Centre for Scientific Research "Demokritos", Athens, Greece.
Georgia Chenevix-Trench
Department of Genetics and Computational Biology, QIMR Berghofer Medical Research Institute, Brisbane, Queensland, Australia.
Thomas A. Sellers
Paul D.P. Pharoah
Centre for Cancer Genetic Epidemiology, Department of Public Health and Primary Care, University of Cambridge, Cambridge, United Kingdom.Centre for Cancer Genetic Epidemiology, Department of Oncology, University of Cambridge, Cambridge, United Kingdom.
Wei Zheng
Jirong Long
For correspondence: jirong.long@vumc.org
DOI: 10.1158/0008-5472.CAN-18-2726 Published February 2019
DNA methylation is instrumental for gene regulation. Global changes in the epigenetic landscape have been recognized as a hallmark of cancer. However, the role of DNA methylation in epithelial ovarian cancer (EOC) remains unclear. In this study, high-density genetic and DNA methylation data in white blood cells from the Framingham Heart Study (N = 1,595) were used to build genetic models to predict DNA methylation levels. These prediction models were then applied to the summary statistics of a genome-wide association study (GWAS) of ovarian cancer including 22,406 EOC cases and 40,941 controls to investigate genetically predicted DNA methylation levels in association with EOC risk. Among 62,938 CpG sites investigated, genetically predicted methylation levels at 89 CpG were significantly associated with EOC risk at a Bonferroni-corrected threshold of P < 7.94 × 10−7. Of them, 87 were located at GWAS-identified EOC susceptibility regions and two resided in a genomic region not previously reported to be associated with EOC risk. Integrative analyses of genetic, methylation, and gene expression data identified consistent directions of associations across 12 CpG, five genes, and EOC risk, suggesting that methylation at these 12 CpG may influence EOC risk by regulating expression of these five genes, namely MAPT, HOXB3, ABHD8, ARHGAP27, and SKAP1. We identified novel DNA methylation markers associated with EOC risk and propose that methylation at multiple CpG may affect EOC risk via regulation of gene expression.
Significance: Identification of novel DNA methylation markers associated with EOC risk suggests that methylation at multiple CpG may affect EOC risk through regulation of gene expression.
Note: Supplementary data for this article are available at Cancer Research Online (http://cancerres.aacrjournals.org/).
Revision received October 16, 2018.
Accepted December 6, 2018.
Published first December 17, 2018.
©2018 American Association for Cancer Research.
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Cancer Res February 1 2019 (79) (3) 505-517; DOI: 10.1158/0008-5472.CAN-18-2726
SATB2-AS1/SATB2/Snail Axis Inhibits CRC Aggressiveness
Oncogenic Roles of SNHG10 and SCARNA13 in HCC
PRC2 Loss: Epigenetic Driver and Achilles Heel in MPNST
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Eco-town plans showcase politicians' ability to keep repeating their mistakes
A few months ago Mike Denham wondered, on the Burning Our Money blog, whether the new eco-towns would be "The Crap Towns Of Tomorrow". After all, the last generation of government sponsored new towns hardly matched up to the initial, idealistic visions. Even the relatively successful schemes like Harlow are now themselves candidates for "regeneration". The less successful new towns have become bywords for urban blight.
Classic mistakes are already beginning to be made. On Monday the BBC reported that those living in or entering the new eco-towns will be kept to a 15mph speed limit. Caroline Flint says that she will "make no apology for setting the bar as high as possible" because there is "a unique opportunity to deliver a programme which will genuinely revolutionise the way people live".
This attempt to use housing policy not to deliver the kind of lifestyle people want but the kind that Ministers think they should want is not just unpleasant and dictatorial, it is almost invariably a dismal failure. Harlow's town centre is in need of regeneration after 60 years, while older centres have been well maintained over centuries, because it couldn't attract the shoppers and other ordinary people whose patronage provides the economic incentive to keep a place looking pleasant. Similarly, the eco-towns will only be a success if ordinary people want to live there.
Outside of major cities a heavy majority of people drive to work. As there is no way for the government to make the eco-towns immune to the impracticalities of public transport and only a limited range of jobs will exist in towns with populations of 5-20,000 residents of eco-towns will drive to work as well. A 15mph speed limit - not just in the centre of town but also on approach roads - will be a endless source of frustration and make eco-towns an undesirable place to live.
While shortages of housing supply will mean that someone will live in the eco-towns, if it is only those with no other choice - who leave when they can - the new towns will quickly fall into unloved neglect. Most of those who profess to care so much about the environment will stay in market towns built millenia ago. It is easy for Flint to 'set the bar high' if she isn't going to be the one facing the frustration of trundling along at half the national urban centre speed limit.
Eco-towns are likely to prove expensive - both financially and in terms of destruction of the natural environment they are built on top of. Unless they are stopped or seriously rethought that cost might be paid just in order to create new urban planning disasters and, as Mike predicted, "The Crap Towns Of Tomorrow". Politicians much prefer the noisy idealism of forcing people to walk to work and 'eco-towns' to carefully thinking through the possible unintended consequences of their actions. Housing policy needs to be brought closer to ordinary people or we will keep seeing the same mistakes being made, decade after decade.


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Internal Medicine Flashcard| Volume 35, e1-e2, November 2016
What could have caused this weight loss?
Rachid Mahmoudi
Department of Internal Medicine and Gerontology, University Hospital, Maison Blanche Hospital, Reims F-51092, France
University of Reims Champagne-Ardenne, Faculty of Medicine, E.A 3797, Reims F-51092, France
Patrick Manckoundia
Corresponding author at: Pôle Personnes Âgées Hôpital de Champmaillot CHU BP 87 909, 2, rue Jules Violle, F21079 Dijon Cedex, France. Tel.: +33 3 80 29 39 70; fax: +33 3 80 29 36 21.
Department of Geriatrics, University Hospital, Champmaillot Hospital, Dijon F-21079, France
Inserm/U1093 Cognition Action Plasticity, University of Burgundy Franche Comté, F-21078 Dijon, France
Jean Luc Novella
Previous ArticlePrevalence and predictors of hyperprolactinemia in subclinical hypothyroidism
Next ArticlePurple urine bag syndrome
Achalasia is rare and often diagnosed late.
It is characterized by functional gastro-oesophageal sphincter obstruction.
Aspiration pneumonia may complicate the achalasia.
Intrasphincteric botulinum toxin injection is one of the main treatments for achalasia.
1. Indication
An 87-year-old woman was hospitalized for a productive cough, wheezing and weight loss. Her medical history included recurring aspiration pneumonia. She had intermittent dysphagia that appeared 2 years earlier, predominantly for solids. She experienced up to 48 h of aphagia followed by dysphagia-free intervals of 4 to 5 days. There was also significant regurgitation of undigested food, causing coughing, bronchial obstruction and aspiration pneumonia. The patient reported worsening digestive disorders and a weight loss of 7 k in the previous 2 years. Biological screening showed hypoalbuminemia (28 g/L). Chest X-ray showed esophageal hydroaeric levels (Fig. 1a ). Barium swallow showed a discreetly tapering lower third of the esophagus with a bird's beak appearance, and esophageal dilatation consistent with megaesophagus and esophageal dyskinesia (Fig. 1b). Gastrointestinal endoscopy showed a dilated esophagus and a large volume of food debris, with no signs of tumor.
Fig. 1Chest X-ray which shows oesophageal hydroaeric levels (a) and Barium swallow which revealed a discreetly tapering lower third of the esophagus in the shape bird's beak, as well as oesophageal dilatation and dyskinesia (b).
What is the diagnosis?
2. Diagnosis
After eliminating secondary causes of esophageal motility disorders, achalasia was diagnosed despite the absence of manometry (patient's refusal). Achalasia is characterized by the incomplete relaxation of the gastro-esophageal sphincter, an increase in esophageal resting pressure and impaired esophageal peristalsis, leading to functional gastro-esophageal sphincter obstruction, and then megaesophagus [
Boeckxstaens G.E.
Zaninotto G.
Richter J.E.
Oesophageal motility disorders.
]. Achalasia is rare (prevalence 10/100,000) [
Enestvedt B.K.
Williams J.L.
Sonnenberg A.
Epidemiology and practice patterns of achalasia in a large multi-centre database.
Aliment Pharmacol Ther. 2011; 33: 1209-1214
] and often diagnosed late. The symptoms, mainly solid and liquid dysphagia, chest pain and regurgitation develop progressively [
]. Weight loss and/or aspiration pneumonia can appear.
The treatment of achalasia includes medical therapy (calcium inhibitors/nitrate derivatives), pneumatic dilation, Heller's myotomy, and intrasphincteric botulinum toxin injection (IBTI). The results of medical therapy are disappointing and the adverse effects cannot be ignored, especially in the elderly [
Dughera L.
Battaglia E.
Maggio D.
Botulinum toxin treatment of oesophageal achalasia in the old old and oldest old: a 1-year follow-up study.
Drugs Aging. 2005; 22: 779-783
]. Pneumatic dilation carries a risk of perforation. Heller's myotomy is rarely performed in the elderly because of surgical risk. Here, IBTI was performed. It led to immediate functional improvement with excellent tolerance. In the elderly, IBTI yields a clinical response in 40–60% of cases at 1-year after one injection, and up to 70% of cases after two injections [
]. In practice, in the elderly, the treatment choice is between medical therapy, although disappointing, pneumatic dilation and IBTI, depending on the patient's wishes and comorbidities.
The early diagnosis and management of achalasia would help to avoid recurrence or serious complications (aspiration pneumonia, malnutrition).
The authors have no conflicts of interest to declare.
The authors are grateful to Mr. Philip Bastable.
Appendix A. Supplementary data
Download .docx (.02 MB)
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Supplementary material.
Accepted: May 9, 2016
Received: February 12, 2016
© 2016 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.


The Water Conservation Garden is pleased to host a special "appreciation day" for ratepayers of Helix and Otay Water Districts, Sweetwater Authority and the City of San Diego. Families will enjoy food and refreshments, kids' activities and special habitat and butterfly gardening presentations by Pam Meisner, Director of Education and Clayton Tschudy, Director of Horticulture at The Garden. Customers will also discover different varieties of drought-tolerant plants, learn how to "Toss the Turf" and get inspiration to incorporate water-wise gardening into their own gardens. Water agency representatives will be on hand to answer questions and provide advice on sustainable water use methods and technology.


The world of technology is improving every aspect of our lives by simplifying processes and providing access to knowledge for all—it's a time of possibility and excitement. As technology is evolving, so is the real estate market. As the online real estate marketing industry becomes increasingly sophisticated, the old days of picking up a real estate catalog or looking at a newspaper for local listings is quickly fading. Homebuyers are becoming more educated with the help of the new technologies. Stay organized and efficient during the hunt for your next home with the most powerful tool in your pocket—your smartphone.
Check out our top 6 "must-download" mobile apps to simplify your house hunting process. Who knows, maybe you'll be a new homeowner sooner than you think!
With a range of filters and searchers from homes for sale to homes for rent, the realtor.com app gives you the power to search for your future home. Updated on a consistent basis, the app is user-friendly and is easy to use in finding a home that meets the needs of you and your family. Make sure to update your app regularly as it constantly updates to provide you the best home shopping experience.
One of the most popular websites for the real estate hunt, Trulia brings you all the best features from its desktop version to its mobile version. With a focus on design to reach a variety of audiences, the apps main screen opens to groupings of home photos rather than a map. With high-resolution photo galleries and essential information on the neighborhood, Trulia brings a home to life on your phone.
An app built for agents, but now loved by homebuyers, Homesnap is used by millions of people nationwide. Homesnap has simplified the process to find your next home. Try out its signature feature and simply snap a photo of any home to find out all about it. Whether you're walking around town, or sitting on your couch, the app is the easiest way to get accurate real estate information.
The most downloaded real estate-related app for both Android and Apple phones, the Zillow app provides users an interactive map and home value estimate—the same capabilities as the desktop form. Zillow's app features homes for sale, rent, recent home sales, foreclosures, and open houses, all at the ease of your fingertips. Make sure to check the "Zestimate," Zillow's industry-exclusive home value system that's used to price more than 100 million homes nationwide.
The Xome real estate app bundles all the steps of real estate into one easy package. The app takes you through the entire buying process from showing you listings, connecting you with agents, scheduling tours, and calculating your mortgage. Put the power back into your hands and download the Xome app to purchase your next home.
Once you have your home picked out, it's important to design it the way you like. Rated the number one home design app, Houzz allows you to browse over 15 million interior designs photos, home decor, and decorating ideas. Whether you want to look at photos, shop for your home, read advice and stories, or find a nearby professional for your design needs, the app gives you the creativity to design the home you've always wanted.
It's fun to use mobile apps to help with the real estate process. When you pair the power of your smartphone with the real estate experts at The Degnan Group at Key Realty, you become unstoppable. For the most professional and knowledgeable realtors in the area, contact The Degnan Group at Key Realty.


An evil medieval army attempting to eradicate your peaceful civilization. You are armed with a legendary bow and can use a variety of spells and different types of magical arrows to defeat your enemy. Use strategy to prioritize your targets and exploit their weaknesses.


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Are Psychedelics Legal In Puerto Rico Yet?
Home » Blog » Are Psychedelics Legal In Puerto Rico Yet?
Magic mushrooms can be found growing naturally all over the island of Puerto Rico.
Despite this, magic mushrooms and most other psychedelics are prohibited, with little to no indication that things will change anytime soon.
Here, we'll discuss the legality of psilocybin along with a handful of other psychedelics in Puerto Rico — including LSD, DMT, MDMA, and more.
Are Magic Mushrooms Legal in Puerto Rico?
No. Magic Mushrooms are illegal in Puerto Rico.
The Controlled Substances Act considers psilocybin, the psychoactive component of magic mushrooms, a Schedule I substance.
Simple possession is a felony, with penalties ranging from three to five years and a fine up to $5,000 for a first conviction. For subsequent offenses, the penalties range from six to ten years in prison.
However, if charged with intent to sell, the mandatory minimum sentence is 20 years and a $25,000 fine.
You can legally buy magic mushroom spores in Puerto Rico because they don't contain psilocybin. However, cultivating magic mushrooms is illegal.
Map of Magic Mushroom Laws In the USA
WA MT ND MN SD WY ID OR NV CA AZ NM PR GUAK CO KS OK TX LA AR MO IA WI MI IL IN OH KY TN MS AL GA FL SC NC WV VA PA NY VT NH RICT MA NJ DE MD ME UT NE DC HI
Do Magic Mushrooms Grow Wild in Puerto Rico?
Yes, you can find magic mushrooms in Puerto Rico.
Many species of psilocybin-containing mushrooms can be found on the island of enchantment.
Psilocybe cubensis, for example, grows from February to December on cow dung or highly fertilized soils in the Barranquitas area. Also, Psilocybe caerulescens spreads gregariously from June to October, which prefers sunny spots and muddy grounds.
In addition, Psilocybe guilartensis is a native species, which grows gregariously mainly in clay or moss. Along hiking trails, you can find it in landslide areas and forests, such as the Monte Guilarte State Forest.
Finally, you can also spot Psilocybe banderillensis and Psilocybe zapotecoantillarum growing on moss in forests.
What Are the Medicinal Uses of Shrooms?
Leading medical and scientific institutions, such as John Hopkins Medicine, call for the reclassification of psilocybin due to its low abuse potential and strong evidence of therapeutic use.
Numerous studies indicate that mushrooms may be helpful for PTSD, cluster headaches, addiction, depression, or existential anxiety in terminally ill patients.
Also, there's evidence that suggests that microdosing magic mushrooms and other psychedelics can improve our problem-solving skills and make us more creative.
Related: What is Psychedelic-Assisted Psychotherapy?
Is LSD Legal in Puerto Rico?
LSD (lysergic acid diethylamide) is illegal in Puerto Rico. It's classified as a Schedule I substance under the Controlled Substances Act.
Possession of LSD is a felony, with penalties of up to five years and a fine of $5,000.
Is MDMA Legal in Puerto Rico?
No. MDMA (ecstasy) is illegal in Puerto Rico.
MDMA is a Schedule I controlled substance, and possession is a felony charge, carrying a fine of up to $5,000 or even three to five years in jail.
However, MDMA may be legalized soon for medicinal use, given the scientific evidence of its efficacy in treatments along with psychotherapy.
Is Ketamine Legal in Puerto Rico?
Ketamine is legal in Puerto Rico, strictly for medical use.
However, possessing it without a prescription is a felony, and penalties go up to a fine that cannot exceed $5,000, or three to five years in prison.
You can only purchase it legally with a prescription, and it is used as an analgesic for surgery, veterinary anesthesia, or as a treatment for severe depression.
Is DMT Legal in Puerto Rico?
No. In Puerto Rico, DMT (dimethyltryptamine) is a Schedule I controlled substance, and penalties for possession range from a fine of up to $5,000 to three years of imprisonment, or both.
Suggested Reading: List of Plants that Contain DMT.
What's The Difference Between Legalization & Decriminalization?
Although they may seem the same, there are critical differences between legalization and decriminalization.
Decriminalizing a substance means reducing penalties and fines, but not entirely. Legalizing a substance means removing all penalties and fines on possession, sale, and cultivation.
This means law enforcement stops prosecuting the user. In addition, the state provides a legal framework for a market to develop.
Key Takeaways: What's The Future of Psychedelics in Puerto Rico?
Although more and more places are opting to decriminalize psychedelics with less risk of abuse, it seems unlikely this will happen soon in Puerto Rico. Although the island has a medical marijuana program that is easy to access, the laws for possession are pretty harsh.
The best we can hope for is a significant change at the federal level, following the general trend towards decriminalization in the rest of the U.S. and Europe.
by supermeds
Are Magic Mushrooms Legal in Puerto Rico?, Is DMT Legal in Puerto Rico?, Is Ketamine Legal in Puerto Rico?, Is LSD Legal in Puerto Rico?, Is MDMA Legal in Puerto Rico?, Key Takeaways: What's The Future of Psychedelics in Puerto Rico?, What's The Difference Between Legalization & Decriminalization
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Man faking madness caught with N250,000, three iPhones, women's underwear in Ogun
A man, said to be pretending to be mentally unstable, was beaten to a pulp by locals after he allegedly found with N250,000, three iPhones, and women's underwear in Ogun state.
It was gathered that the suspect, who stays under the bridge in Mowe, in the Obafemi Owode Local Government Area of Ogun State, was caught answering a call on Thursday, July 29, and it made residents suspicious to see a supposedly mad man answering a call.
According to, residents asked where he got the phone from but he could not give a satisfactory answer, instead, he tried to escape.
Residents caught him before he could go far and they searched him. They allegedly found the sum of N250,000, three iPhones, and women's underwear in his possession, and the locals descended on him, beating him.
An eyewitness, who identified himself simply as Ade, told Punch that he and his friends were placing a bet under the bridge when they saw the suspect making a phone call so they confronted him.
The eyewitness added: "He had been at the Mowe bus stop for long and when some passers-by saw what we found on him, they pounced on him and beat him.
"We later handed him over to the police, but policemen at the Mowe Police Division said they could not accommodate a lunatic in their station. Only God knows who he was calling."
A trader in the area, identified simply as Yetunde, said the suspect was beaten when he refused to disclose who he was talking to on the phone.
She said, "When he was asked who he was talking to, he refused to talk; it was the annoyance that made people to start beating him and wondering where a lunatic got such amount of money, phones and women pants and bra from. This is an eye-opener to everyone in Mowe. Only God knows how many atrocities he has committed in Mowe.
"Probably he is working with ritualists, because I don't know where he got the money and the phones, and maybe the underwear belong to women he raped or killed and sold their body parts."
See also Wike pledges N500 million to Sokoto but unwilling to pay Rivers pensioners
Tags: iPhone Ogun Police command
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Q: How to repeat a value each x cells? The idea is to have 2 inputs the number and the number of spaces, so lets say those numbers are 2 & 3 it should look like:
2
0
0
0
2
0
0
0
2

A: If first parameter is in A1, second in B1, you can enter the following formula in any cell, and fill it down:
=IF(MOD(ROW(A1),$B$1+1)=1,$A$1,0)

A: Your sample data is confusing in that there are three 2's and three zeroes. It's unclear on what it should look like if the second number was a 4. If it is always three of the first number try something using REPT. With 2 in A1 and 3 in A2,
=A1&rept("0", A2)&A1&rept("0", A2)&A1

A: Pick a cell and enter:
=IF(MOD(ROWS($1:1),4)=1,2,0)

and then copy down:


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What Is The Difference Between Prokaryotic And Eukaryotic Cells?
Updated on: 22 Apr 2019 by John Staughton
What Are Prokaryotic Cells?
What Are Eukaryotic Cells?
3.5 billion years ago, the world was a very different place, and almost entirely unrecognizable from how things are now. There was also no oxygen in the atmosphere, making it impossible for life to thrive. However, that is when something quite remarkable happened – the rise of prokaryotic cells.
It is from these earliest scraps of life that all the magnificent diversity on this planet have evolved. For that reason alone, understanding the key elements of prokaryotic cells, their history, and their role in the present is well worth your time.
Prokaryotic cells are defined by their lack of any membrane-bound organelles, including a nucleus. They are extremely simple structures, and their limited contents float freely in the cytoplasm of the intracellular space. Prokaryotic cells may contain DNA, proteins and metabolites, but they are not bound or sectioned off within the cell. Many of these simple cells also have flagellum for movement, a cell wall and cell membrane, ribosomes, cytoplasm, and the nucleoid area, where the genetic material is suspended.
Most experts agree that prokaryotes were the first form of life, having likely evolved from protocells approximately 3.5 billion years ago, and from there, the two earliest domains of life arose: Archaea and Bacteria. The vast majority of prokaryotes are unicellular, although some cyanobacteria can be multicellular. Whenever you hear about a type of bacteria, that is a type of prokaryote, since they contain no nucleus and possess an external protective shell.
(Photo Credit : Wikimedia Commons)
It is also important to note that prokaryotic cells are found almost everywhere, across the globe, even in some of the harshest conditions this planet has to offer. They are in the dirt, the air, steaming hot springs, as the bottom of the ocean and everywhere in between. Their ability to adapt to extreme environments has made them the most ubiquitous form of life on Earth.
The distinction of something being a prokaryote or a eukaryote is perhaps the most notable difference between any organisms, as all the other domains of life are eukaryotic, and evolved later in Earth's history. Prokaryotic cells tend to be smaller than eukaryotes, and have a higher surface area to volume ratio. They also have a higher metabolic rate than eukaryotes, allowing them to grow and reproduce faster. This aggressive ability to reproduce is what makes certain bacterial infections so dangerous.
When it comes to reproducing, prokaryotes are also notably different than most forms of life. Whereas humans (and nearly every other species) carry their genetic information on chromosomes, prokaryotes only have a single loop chromosome of DNA that is found in the nucleoid. The genome of prokaryotes is highly concentrated and functional, with almost every piece of DNA coding for some essential function, which is also different from more complex forms of life. Most prokaryotes will only contain one copy of each gene, and transcription and translation can occur simultaneously during reproduction. Unlike the fusion of gametes to replicate more complex cells, prokaryotic cells divide through binary fission.
Eukaryotic cells are a bit easier for most people to understand, because they are the cells that are filling your entire body! Eukaryotic cells are those that have a membrane-bound nucleus and organelles, as well as multiple chromosomes in a multicellular organism. Every animal and plant you have encountered in your life follows this more advanced structure, as it allows for many more complex processes to occur.
Eukaryotic cells are believed to have evolved from prokaryotic cells consuming one another. Imagine that a large prokaryote was blindly moving through the world in search of food when it encountered a smaller prokaryote. Through a process called endocytosis, it consumed the smaller cell, but did not digest it. Instead, an endosymbiotic relationship was formed, in which both prokaryotes could live healthy and happy in their new arrangement. The theory goes that these smaller prokaryotes began reproducing along with the larger one, until the small cells eventually evolved into mitochondrion – the energy factories of a cell. The larger cell provided a safe space for the smaller one, while the smaller one creates usable energy for the larger one.
It is believed that a similar endosymbiotic process occurred when a large prokaryote consumed a cyanobacteria, which was the first form of life on earth that could photosynthesize, thus creating its own food and releasing the very first puffs of oxygen into the atmosphere. When these cyanobacteria were consumed, they spent a few million years evolving into chloroplasts, a critical organelle for photosynthesizing creatures. From that point on, eukaryotic cells became more and more advanced, and had the capacity to grow and evolve through processes like cellular respiration and photosynthesis.
Eukaryotic cells also divide and multiply in a different way that prokaryotes; namely, through mitosis or meiosis, rather than cellular fission. As mentioned before, eukaryotic cells carry their genetic information on chromosomes, within the nucleus, where our DNA (composed of nucleotides) is tightly wrapped around a protein called histone. Unlike prokaryotes, most eukaryotes contain two copies of the same gene, making them diploid. There is also a great deal of excess genetic code in eukaryotes; sometimes as much as 95% of the genome doesn't directly code for anything. Finally, since there are clear divisions between organelles in the cell, transcription will occur in the nucleus, whereas translation will happen in the cytoplasm.
The distinction between prokaryote and eukaryote is incredibly important and reveals a key moment in the history of life on this planet. Most experts believe that eukaryotes evolved between 1.5 and 2 billion years ago, meaning that all of those prokaryotes were floating around in an ancient soup for nearly 2 billion years before the first organelle evolved. Since that critical moment, the pace of change on the planet has sped up enormously as oxygen filled the atmosphere and life began to diversify and grow. From the very first single-celled organism, the most basic bacterium, we have come a very long way, evolving and spreading our eukaryotic cells across the world.
LibreTexts
Book: Eukaryotic And Prokaryotic Cell Structures – By Lesli J Favor PhD
The short URL of the present article is: http://sciabc.us/EyGCW
John Staughton is a traveling writer, editor, publisher and photographer who earned his English and Integrative Biology degrees from the University of Illinois. He is the co-founder of a literary journal, Sheriff Nottingham, and the Content Director for Stain'd Arts, an arts nonprofit based in Denver. On a perpetual journey towards the idea of home, he uses words to educate, inspire, uplift and evolve.
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Tags: Biology


Luke Gibson has been named the South Atlantic Conference Scholar-Athlete for men's basketball.
Newberry's first-ever Academic All-American in men's basketball becomes fourth Newberry men's basketball player to earn the award in the last five years. The prestigious honor equally weighs athletic achievement with academic success and community service.
Head coach Dave Davis is proud of Gibson's achievements, saying, "Luke Gibson has been the consummate student athlete in his entire time here. What an incredible honor for him and he truly deserves this award."
Gibson, a junior, boasts an exceptional 3.98 GPA as an accounting major. The Albemarle, N.C. native has been named to the Dean's List in each semester at Newberry College.
The junior started in 18 games in Coach Davis' five-in, five-out system, asserting himself as one of the leaders on a young Wolves squad. Gibson was third on the team in scoring this season, averaging 11.2 points per game while leading the team in both three-point percentage (.385) and three-point field goals made (65). He's also served as the iron man for Newberry this season, playing in every game and leading the way in minutes per game (25.8).
Gibson has a long resume of community service activities during his time as a Newberry student as well. The junior has worked with multiple special olympics basketball events hosted at Newberry, as well as serving as volunteering as a referee-coach with the Law Enforcement & Youth Basketball Tournament meant to improve relations between law enforcement and community members.
During his freshman and sophomore years, Gibson served as a weekly Spanish Academy volunteer at Newberry Academy, as well as participating in a weekly team activity at Gallman Elementary where he assisted a classroom teacher. Gibson's efforts earned him an exclusive selection to attend the NCAA Division II APPLE Institute in Dallas to promote student-athlete wellness and substance abuse prevention; using the tools he learned there, he will work with a team to create and implement a Newberry-specific action plan on this topic.
Gibson becomes the 20th SAC Scholar-Athlete across all sports at Newberry College.


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A solid actor who assumes the weight of heavy responsibilities with ease. Her filmography is full of brave choices
Han Jimin
Han Jimin is in full bloom with her profound acting in melodramas. Since she was a teenager, she has been active in commercials and music videos. She began acting in 2003 when she starred as the child actor of Song Hyekyo in All In, the popular TV series. Han played Lee Junghee, a female aviator in the film Blue Swallow (2005), and starred for the first time in the horror film Cadaver (2007), which depicts bizarre events that occur while medical students practice anatomy. It was Yi San, Wind of the Palace, the TV historical drama in 2007 that showed the actor's talent and star quality in full. Han played Seong Songyeon, who helped King Jeongjo Yisan's dream, fell in love, and became a royal concubine later.
After that, Han Jimin showed a femme fatal charm through Han Kaekju in Detective K: Secret of the Virtuous Widow (2011), a fusion costume film that attracted public attention. She also showed Asian beauty, especially with the image of a woman in a traditional Korean dress, the Hanbok, while playing Park Ha in the 2012 romantic comedy series, Rooftop Prince. In the historical drama The Fatal Encounter (2014), she appeared as ambitious Queen Jeongsun, who harassed King Jeongjo (Hyun Bin), transforming her image into a villain. On the other hand, through the romantic comedy The Plan Man (2014), she got out of costume dramas and gave off various witty and cheerful charms. Han expanded her acting career into romantic comedies by playing Yoo Sojung, a singing and dancing musician.
She played Minjeong, a daughter of Geumnim (Yun Yuhjung), in the film Salut d'Amour (2015) and Yeon Gyesoon, a member of the Heroic Corps, who chooses to die in prison in The Age of Shadow (2016). In the short film Two Lights: Relumino (2017), the actor played Sooyoung, a character that is visually impaired. With a warm story about falling in love with a man who is losing his sight, the film shows Han Jimin's characteristics. It was the melodramatic genre that would maximize her sensibility and softness as it was often said, 'Melodrama is second nature for her.' That was why she played a double role with senior actor Kim Hyeja in the 2019 TV drama Dazzling. The image of her falling in love was enough to satisfy many people's expectations.
Her turning point as an actor was with the film Miss Baek (2018). She played the role of Baek Sangah, a low-life figure who finds the meaning of life by helping a young girl in a difficult situation. She Han showed solid acting skills without compromising her unique soft charm. It became known as the 'Rediscovery of Han Jimin.' The film received rave reviews as she swept Best Actress at many film awards, including the Blue Dragon Award. The evolution of her acting led to Josée (2020). She plays the character Josée, who is handicapped and in a wheelchair. She falls in love with Youngseok (Nam Joohyuk). Josée opens her heart by habitually saying, "Eat before you go!"
However, knowing that their love cannot last, Josée calmly accepts to say farewell. Han Jimin's acting range is shown through Josée's sympathy is added to the energy of Baek Sangha, an unyielding character. Han Jimin has proved that she can have her own voice not only in melodramas but also in stories against the harsh world and the fetters of life.
<Josée> (2020)<My Name Is KIM Bok-dong> (2019) narration<Default> (2018)<Miss Baek> (2018)<Herstory> (2018)<Keys to the Hear> (2018)Short film <Two Lights: Relumino> (2017)<The Age of Shadows> (2016)<Salut d'Amour> (2015)<The Fatal Encounter> (2014)<The Plan Man> (2014)<Detective K : Secret of Virtuous Widow> (2011)<Cadaver> (2007)<Blue Swallow> (2005)


It could be demolished, but some preservationists are pushing for its salvation, along with other community members who also want to preserve it for its practical value.
We're at the Mayor's Agent hearing to #SavetheTrestle from demolition. The historic Foundry Branch Trolley Trestle could be reused as a pedestrian and cycling path, but WMATA wants to demolish it before a complete reuse study can be completed by DDOT.
Metro has submitted a permit to tear down the trestle, claiming that the transit agency will face economic hardship if the permit is denied. Metro earlier had told WTOP that the bridge has to be torn down due to its deteriorated condition, and because of their main focus is keeping the transportation system safe for its passengers.
The Mayor's Agent on Historic Preservation held a public hearing Friday regarding Metro's permit to raze the streetcar bridge.
The DC Preservation League tweeted that discussion of Metro's permit will continue until the District Department of Transportation completes its Palisades Trolley Trail and Foundry Trestle Feasibility Study in August.
Brett Young, who lives in the Palisades neighborhood and was at the permit hearing, agrees with Friday's decision by the Mayor's Agent.
Young also said the streetcar bridge is historic and can have practical value as well.
"We could be reusing it for encouraging more cycling, more paths to walking, dog walking," Young said.
He said preserving the bridge could also help D.C. meet some of its traffic safety objectives by providing another pathway for pedestrians and cyclists to commute from their homes to other points in D.C. and beyond.
"It's a dedication to Vision Zero, a safer environment where the pedestrian and the cyclist are in a safe environment," Young said. D.C.'s Vision Zero plan involves shrinking traffic fatalities and serious injuries to zero by the year 2024.
The Foundry Branch Trolley Trestle is at "imminent risk of collapse," and trail users are being advised to detour around the danger.


Time for the sixth day of Stamping Bella Summer 2018 release peeks!
There are some brilliant new stamps in this release (aren't there always?), so make sure you stick with us for all of the peeks! Today we're showing off some more awesome new images together with something else exciting – standalone word dies!
The stamps and coordinating dies will all be available to order as of Monday 25th June 2018 at Stamping Bella.
UK/Europe based readers: lovely Tracy at Dies to Die For has the release on order so make sure you stalk her for them!
As always, I filmed the colouring process for each of the new stamps. I will be uploading them a few at a time, and sharing them in these preview posts, and for a little while following the release. If you don't want to miss any of my videos, please do subscribe to my channel over on YouTube.
All images have been coloured using Copic Markers on Make it Colour Blending Card.
First up, lets take a minute to get excited about the new addition to the Stamping Bella range – STANDALONE WORD DIES! Whoo! I love a word die for adding a bold sentiment to a card, and the best thing about these? Each set includes THREE sizes of the same word. So much fun. Over the past two days we've seen the MWAH and Smile sets, now we have Celebrate and Happy!
Just a perfectly whimsical selection of flowers to create scenes with the other Little Bits sets!
Watch me colour this set in the video below or in HD over on YouTube.
These are great on their own, or together with the other Little Bits characters and elements! I used mine with the gorgeous Celebrate die set.
Watch me colour this sweet set in the video below or in HD over on YouTube.
I hope you have enjoyed today's post as much as I enjoyed creating it for you. Be sure to visit the Stamping Bella blog for more inspiration from the Bellariffic Babes and a chance to win a voucher!
Don't want to miss out on future posts? Subscribe to my RSS feed in your favourite blog reader or subscribe via email using the form over in the sidebar.
If you want to keep an eye on what I'm colouring on a daily(ish) basis, follow me over on Instagram where I share frequent peeks at the colouring I'm doing along with other day to day snaps. You can also follow my page on Facebook if you'd like to connect over there.
Please note that in order to assist with the running of this blog I do use affiliate links from time to time and there may be some in this post, denoted with a *. Please see my About page for more information.
This entry was posted in Cards, Colouring, Tutorials & Videos on June 23, 2018 by Elaine.


Discoveries in Health Policy: Is the FDA FMI CDx Approval "Really" A Very Elaborate Analytical Validity Assessment?
Is the FDA FMI CDx Approval "Really" A Very Elaborate Analytical Validity Assessment?
In mid-December, the FDA released its main safety & effectiveness review document on the Foundation Medicine CDX 384-gene test (here). As commentators have noted, CMS gives very high priority to FMI's PMA approval - "This tells us that it really has clinical utility." Far lower status is given to tests with published data, NYSDOH approval, or the new 510(k) somatic gene panel approval. As proposed, those tests get coverage only if $10,000 or more, such as RECIST studies, are deployed for each test paid by CMS.
The 58-page FDA review is worth reading in detail, which probably few people have invested several hours in doing. The review is mostly an exhaustive analytical validity assessment. FMI CDx is verified to have 700-800X coverage for targeted regions; which was information already used in publications, its website, I assume its CAP validations, NYS approval, and MolDX approval. FMI CDx has a net sequencing error rate of .003 percent (below the FDA's stated threshold of .01 percent or 1 base in 10,000). But again, this is sequencing accuracy level that is known to be met for clinical genetic tests. And it's analytical data.
The heart of the review assesses the performance of six very specific outputs of the FMI CDx test against six prior art PMA comparators, as diverse as the Ventana ERBB2/Her2 FISH test and the Roche EGFR T790M point mutation test.
Two of the comparisons involved clinical blocks, but these were much noisier (with missing blocks, differing results, etc) than the four comparisons that involved running the predicate test on merely available tumor blocks.
The two comparisons that are cross-modality (between ALK FISH and ERBB2 FISH and sequencing) are much noisier than accuracy between an FMI point mutation and a PMA kit point mutation. I summarize the results in the first figure below by gene reviewed, and give representative examples of "very tight" and "noisier" concordance in the second figure below.
I provide a more detailed, but still informal, summary of the S&E key findings in a sidebar blog, here. In general, whether clinical trial or "available" blocks were used, about 100-150 positive blocks and a similar number of negative blocks were required. However, even when clinical trial archives were used, the assessing for a passing grade is based on the analytical validity concordance of FMI and prior art results.
The FDA approval is, no question, an exhaustive view that gives a great deal of confidence in the test. But few commenters actually read it. The key pivotal tables are mostly based on "available" blocks. All the data on concordance to prior art is "analytical" and "statistical." The bar is within 10% noninferior to a comparator.
It's a big, big achievement. But I'm unconvinced it's light-years and night and day different than an academic NGS test which has, say, 99% concordance to Sanger in hundreds of specimens and 95-99% concordance to an IVD in dozens of specimens. Or for that matter, the 99.9% accurate MSK IMPACT test with its new 510(k) approval.
As I noted earlier (here), the FDA review defines away any issues about accuracy outside the claims. The FDA tested accuracy in some cases to match a single point mutation; in writing up its pivotal risk-benefit decision, FDA states that: the test matches those several cases of prior PMA art and therefore the whole test (which also reports sequencing on some 377 other genes and things like Total Mutational Burden) introduces no new medical issues or risks beyond the prior art such as a point mutation T790M test or a point mutation L858R test.


Class containing current Net2Plan-wide options, and methods to work with them.
Important: Values are stored in String format. Users are responsible to make conversions to the appropiate type (i.e. double).
Important: Users should not access this class directly. All interfaces for implementing user-made code (i.e. algorithms) include a map so-called net2planParameters as input parameter, where users can find the current configuration of the tool (e.g. IAlgorithm.executeAlgorithm()) .
Checks the given options for validity.
Returns the default name of the library file (to set as solverLibraryName in JOM calls), defined by the user for the given solver name.
Returns the current map of Net2Plan-wide options.
Returns the list of Net2Plan-wide parameters, where the first item of each element is the parameter name, the second one is the parameter value, and the third one is the parameter description.
Returns the value of an option.
Returns the current map of options (inlcuding ones those from plugins).
Reads options from the default file.
Reads options from a given file.
Saves current options to the file system.
Sets the default name of the library file (to set as solverLibraryName in JOM calls).
Puts the value for an option.
Puts the value a set of options.
Goes through this map of parameters and, if both the parameters solverName and solverLibraryName exist, and solverLibraryName equals "", then sets the value of such parameter to the default library file set by the user (in user->options) for such solver.
name - The file name that will be defined at the Net2Plan options.
Puts the value for an option. If an option already exists, its value will be overriden.
Puts the value a set of options. If an option already exists, its value will be overriden.


Think of your kitchen as one big tasty medicine cabinet.
Low-fat, plain yogurt is a healthy protein without the saturated fats, Fung said. It doesn't spike up blood sugar levels and contains probiotics — microorganisms that promote the good bacteria in the digestive system.


text:
'Resistance' to California Republican: 'May You Die in Pain'
Mobilize Chico / Twitter
Left-wing "resistance" activists flooded a town hall meeting Monday held by Rep. Doug LaMalfa (R-CA) in Chico, California, with one attendee taunting the congressman: "May you die in pain!"
According to the Los Angeles Times, that attendee was an "older man" upset by LaMalfa's vote for the House's version of legislation to repeal and replace Obamacare, the American Health Care Act. Others present were also opposed to repealing Obamacare.
The Times reports that most other comments and questions were "cordial," though LaMalfa was often interrupted. It is not clear what proportion of people in attendance at the Chico Elks Lodge were actually from California's 1st congressional district, which encompasses a large swath of the northeast part of the state, and which LaMalfa has represented since 2013, winning re-eleciton by wide margins.
The 1st district also includes a large portion of the proposed "State of Jefferson," where many residents feel alienated from the Democrat-dominated state government, and where Donald Trump trounced Hillary Clinton in the 2016 presidential race, contrary to the rest of the state.
Still, activists from the so-called "resistance" have been known to organize attendance at town hall meetings in the conservative interior of the Golden State, where they target Republican representatives for vociferous protest.
In some Republican-held districts, Democrats are crafting their messages more carefully. The Times notes a new campaign ad from Democrat Dave Min, one of several challengers hoping to take on Rep. Mimi Walters (R-CA) in Orange County. The ad, "Country of Immigrants," touts Min's "progressive values" and attacks Trump's policies on illegal immigration. "I'm profoundly concerned about my kids growing up in Donald Trump's America," Min says.
Democrats hope to flip several Republican-held seats in California, particularly in districts where Clinton defeated Trump. LaMalfa's is not one of them — though LaMalfa declined to support Trump in the 2016 Republican primary.
Joel B. Pollak is Senior Editor-at-Large at Breitbart News. He was named one of the "most influential" people in news media in 2016. He is the co-author of How Trump Won: The Inside Story of a Revolution, is available from Regnery. Follow him on Twitter at @joelpollak.
HealthLocalPolitics2018 house races2018 midtermsDoug LaMalfaObamacareresistance


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