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Home All Specialties Gastroenterology
Decrease in symptom severity linked to infliximab Crohn's treatment [Pediatrics Classics Series]
byLeah Carr, MDandLewis First, MD
in Gastroenterology, Pediatrics, Pediatrics Classics, The Classics
1. The severity of Crohn's disease as assessed by the Pediatric Crohn's Disease Activity Index in patients recruited from 3 pediatric specialty centers decreased significantly over the course of a 12-week treatment regimen with infliximab.
2. All patients were on corticosteroids at the start of the study; however, steroid administration decreased significantly over the course of the investigation.
Original Date of Publication: August 2000
Study Rundown: Crohn's disease is an inflammatory bowel disease (IBD) often diagnosed in adolescence and young adulthood and results from an immune-mediated, inflammatory process with the potential to affect any portion of the gastrointestinal tract. Knowing that tumor necrosis factor –α (TNF-α), a cytokine involved in the modulation of the inflammatory responses, is increased in patients with Crohn's and that the drug infliximab (Remicade) acts to neutralize TNF-α, this study built upon encouraging research in adult patients in investigating the potential utility of infliximab in the pediatric population. In this study, 19 patients with poor response to other therapies were started on varying infliximab dosing schedules. All patients were on daily prednisone at baseline. Crohn's disease symptom status was assessed at baseline, 1 month, and 3 months into the study through physician assessment and use of the Pediatric Crohn's Disease Activity Index (PCDAI). Over the study period, the severity of Crohn's symptoms by PCDAI score and the doses of steroids used to treat disease decreased significantly. This study was limited by the variation in infliximab dosing schedules, lack of a control group, and small sample size. However, it stands as one of the first studies to investigate the use of infliximab in a pediatric population with Crohn's and indicated many potential positive outcomes.
Following Food and Drug Administration approval in 2006, infliximab was and still is used in pediatric patients with moderate to severe Crohn's who have not responded adequately to other therapies. While only 3 of the 19 patients in this study experienced any type of adverse reactions, adverse effects from long-term use, including lymphoma, are of major concern in patients. The risk of malignancy along with other severe reactions continues to be investigated. In addition, many patients with Crohn's are on combined therapies, the efficacy and adverse effects of these regimens are also under investigation.
Click to read the study in The Journal of Pediatrics
#VisualAbstract Drug survival of etanercept was significantly lower than other biologics in patients with hidradenitis suppurativa
#VisualAbstract: Dual therapy with infliximab and IVIG in children with multi-system inflammatory syndrome
#VisualAbstract Risk of serious infection in patients with moderate to severe psoriasis is associated with the type of biologic treatment
In-Depth [prospective cohort study]: Pediatric patients with Crohn's disease, treated at 3 IBD specialty centers, and who had responded poorly or not at all to previously treatment strategies or depended entirely on corticosteroids, were eligible to participate. A total of 19 patients were recruited (average age 14.4 years, with a mean 3.5 years since diagnosis) to receive infliximab administered intravenously at a dose of 5 mg/kg over 2 hours. The number of treatments varied among participants. Treatment outcomes were assessed by physician assessment and the PCDAI, a physician-completed health evaluation, filled out prior to infliximab treatment and then 4 and 12 weeks after initiation. Patients were followed for an additional 3 to 9 months following the 12-week evaluation. At the time of treatment initiation, all patients had moderate to severe disease as measured by the evaluation tool and all were on daily corticosteroids with 14 participants on an additional agent.
Over the course of treatment, all patients experienced symptomatic improvement. After 4 weeks of therapy, 9 patients were asymptomatic and PCDAI values significantly decreased from 42.1 + 13.7 to 10.0 + 5.6 (p < 0.0001). Over the 12 week study period, patients became increasingly symptomatic, but the 12-week PCDAI still remained significantly lower than the score at the time of treatment initiation at 26.8 + 16.4 (p < 0.01). Prednisone dosing decreased over the course of the study with doses at both 4 weeks and 12 weeks significantly lower than at baseline (28 + 14 mg at baseline v. 20 + 12 mg at 4 weeks and 8 + 12 mg at 12 weeks, p < 0.01) and 9 participants on no corticosteroids at the study's conclusion. At final follow-up, 3 patients had inactive disease, 9 had mild disease, and 4 had moderate disease. 3 patients experienced adverse reactions such as dyspnea and rash which were controlled in 2 who received pretreatment with diphenhydramine prior to administration of infliximab.
© 2013 2minutemedicine.com. All rights reserved. No works may be reproduced without expressed written consent from 2minutemedicine.com. Disclaimer: We present factual information directly from peer reviewed medical journals. No post should be construed as medical advice and is not intended as such by the authors, editors, staff or by 2minutemedicine.com. PLEASE SEE A HEALTHCARE PROVIDER IN YOUR AREA IF YOU SEEK MEDICAL ADVICE OF ANY SORT.
Tags: Crohn's DiseaseIBDInfliximab
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Priwallpromenade 29 Apartment 18 is located in Priwall. This apartment offers accommodation with free WiFi. The apartment features 2 bedrooms and a living room with a TV and Blu-ray player. The accommodation is fitted with a kitchen with a dishwasher and microwave. Priwallpromenade 29 Apartment 18 offers 5-star accommodation with a hot tub. Lübeck is 20 km from the accommodation. Hamburg Airport is 83 km away.


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Destiny: The Taken King Review
Animal Crossing: Happy Home Designer Review
by Mike Stubbsy on September 22, 2015
PlatformPCPlayStation 3PlayStation 4Xbox 360Xbox One
DeveloperEA Canada
PublisherEA Sports
Reviewed OnXbox One
There is no game quite like FIFA when it comes to making you scream expletives at your TV. Whether you are playing alone, online, or when FIFA is (perhaps) at its best: locally, you're going to swear at the ref, the developers, or the asshat sat next to you who just ran past your entire team and slotted the ball into the bottom corner in the 89th minute. This is a game that invokes emotion like no other, and while over the last few years rage has been a common feeling when playing, this year relief and satisfaction are much more common.
One of the many criticisms of FIFA has been that it always felt like attacking was the main focus, with little reason to keep possession across the back line or in the midfield. Getting it to your strikers was always the priority and usually the best tactic, but this year things are a little more balanced across the pitch. Keeping the ball moving across midfield, while trying to draw out the opponents is a tactic that has served me well. Once a defender moves out of position, a gap usually appears and a well-timed through-ball (on the ground through-balls seem to be the way to go this year) or use of the new passing with purpose modifier that puts some serious pace on a pass to get it there quickly can often lead you through on goal.
But it isn't quite the surefire way to score that over the top through-balls or finesse shots have been in the last few years. The defensive AI has been significantly improved in relation to cutting out passes and, unless your pass is risk-free or pinpoint accurate, there is a high chance it will be cut out. While that may sound infuriating, it actually works well and makes things seem much more realistic. Almost every pass in the final third is contested in some way, unless you get a pocket of space, making it feel like it was a really good passage of play that lead to the shot.
There are also lots of improvements for when you don't have the ball. While many of the new changes on the defensive side are incredibly minor on their own, when put together they make winning the ball back a lot easier. Quicker turning animations, better AI tracking of runners, and the ability to jump up out of a missed slide tackle with a single button press to keep momentum make defending the best it has been for years, and the most enjoyable, to boot. Add in the much improved (providing you play on professional or higher) goalkeepers, and goals start to become much more of a rarity. Whereas a 3-2 or 4-3 would be classed as a close game in previous years, this year a 1-0 win is the more common score line.
Just because it seems harder to score this year doesn't mean that the incredible goals which FIFA is known for have disappeared. I have had a good number of goals that made my jaw drop, and even goals that sound fairly mundane when describing them can have a massive impact. Such as the time Michael Carrick bulldozed past two defenders, leapt like a salmon and powered a header into the bottom left corner, it sounds like a fairly boring goal but in that moment it looked amazing.
On the pitch there is very little to complain about. On easier difficulties attacking down the wings and cutting back inside seems a bit too easy, and there is still the odd questionable physics interaction between players, but other than that there is very little wrong. That doesn't mean it's quite perfect; there have been a few things such as strange own goals and misplaced passes directly to my striker within the last five minutes of a close game that made it almost feel like the game was giving me as much of a chance a possible to score. But overall it is incredibly satisfying to play and even more so to score a goal.
As ever, Ultimate Team returns with some fairly minor changes to the main game mode, although the new addition of FUT Draft is certainly welcome. This gives you the option to build a super team to use in up to four games (a loss means your run with that team is over) by selecting one of five randomly selected players for each position. For those of us who will never have enough coins to buy the likes of Ronaldo or Messi, Draft Mode provides the chance to at least have them in our squad for a few games. How many wins you manage to get depends on the type of pack you receive as a reward, but with a 15,000 coin entry fee it can be considered a financial risk for those highly invested in traditional Ultimate Team.
Career mode has also had some small but very welcome chances. The first one you will notice is the addition of pre-season tournaments that offer up bonus transfer funds if you perform well. In my career with Manchester United I headed to the USA to play in a tournament consisting of the likes of Boca Juniors, Barcelona, and Atletico Madrid, and I managed to secure an extra few million in transfer funds by coming second. Player training allows you to set specific training drills for up to five players a week to help them improve. For those looking to put a lot of time into career mode this seems like the obvious way to boost any young players you have to make them future super stars. Interestingly, you can also take part in the training as a skill game to improve your playing skills.
Of course, EA has also added women's football this year, and they play significantly differently to the men. It feels slower and there is more space on the pitch, which is actually very enjoyable, but I doubt anyone will spend all their time playing with the women's teams – they are a nice addition but ultimately it is more of a distraction than anything else. Although their inclusion has resulted in all hair now being realistically simulated, which does look really good in replays, and visual upgrades are always welcome.
There is no doubt that this is easily the best FIFA game of this generation. The game modes that have been at the heart of the series over the last few years remain as good as they have ever been with a few minor additions, and FUT Draft offers up an interesting new prospect for those who tire of the traditional mode. On the pitch the action is the most balanced yet, with the midfield actually being a key part of any game for the first time in a while, and somehow they have managed to make defending fun, instead of incredibly frustrating. There are still a few issues here and there, and some may question if the relatively minor changes from last year are worth shelling out for an entirely new game, but this is without a doubt the best FIFA in years.
Review code provided by publisher.
Amazing goals still pop up regularly.
Most balanced on-pitch action for years.
Pre-season tournaments are finally in.
Mostly minor changes.
Occasional physics issues.
Lots of small improvements both on and off the pitch make this the best FIFA in years.
ea sportsFIFAPC
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FIFA Ultimate Team releases new TOTW stars for Black Friday
FIFA 21 FUT TOTW 8 revealed
David Beckham is back in FIFA 21
NHL 21 review
What's new in NHL 21? A primer for this year's game
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Federalist Party
1900 (Partido Federalista)
1953 (Third Republic)
January 17, 1981 (Fourth Republic)
April 30, 2018 (Partido Federal ng Pilipinas)
1910s (Partido Federalista)
Late 1981 (Fourth Republic)
Pro-Statehood
Politics of the Philippines
Federalist Party or Federal Party refer to political parties that advocated federalism in the Philippines. Before the recognition of Philippine independence in 1946, several iterations advocated the annexation of the Philippines as a U.S. state through Federalist Party.
Prior to the 2016 general elections, the PDP–Laban initiated moves to revise the 1987 Philippine Constitution and field then Davao City Mayor Rodrigo Duterte to promote the proposal to shift to a federal form of government. This led interest from various groups to convince Duterte to run for president. When Duterte became the 16th President of the Philippines in 2016, a separate Duterte sympathetic group, initiated move to launch a Federalist Party through Partido Federal ng Pilipinas (PFP)
Insular government era (1900–1907)
Main article: Progresista Party
After the cessation of hostilities in the Philippine–American War (then known as the "Philippine Insurrection"), political parties were allowed to be formed for the first time. The Partido Federalista (Federal Party) was one of the first to be formed, on December 23, 1900. In the establishment of the Philippine Assembly, delegates such as Pedro Paterno, that pushed for Philippine statehood within the United States, formed the Partido Federal; the party was favored by the American insular government, which appointed delegates in the assembly. The Federalists elected Trinidad Pardo de Tavera as party president and dominated Manila politics. Their primary opponent were delegates that advocated immediate independence; these would later form the Nacionalista Party. The nationalists would wrest control of the assembly starting in 1907 when the first elections were held. At this point, the power of the Federalists waned, and their statehood platform was rescinded, and the party was named as the Progresista Party.[1]
Third Republic (1953–1961)
A "Federal Party" existed during the Third Philippine Republic. Alfredo Abcede was a two-time presidential candidate of this Federal Party. In 1957, Abcede lost, winning 470 votes nationally or less than 0.01%. In 1961, he lost again, polling a mere seven votes. Abcede also ran for the Senate in 1953, 1955 and 1959, losing each time, and never getting more than 0.5% of the vote.[2]
Fourth Republic (1981)
Former Representative from Cebu Bartolome Cabangbang was one of the candidates in the 1981 presidential election overwhelmingly won by the incumbent president Ferdinand Marcos. This election was boycotted by most opposition parties when their preferred candidate, Benigno Aquino Jr., was barred from running for being underage. Cabangbang's platform of the Philippines becoming the 51st state of the United States earned him a surprising 4% of the vote, attributed to the people's yearning for the American colonial administration in preference to Marcos' just-concluded martial law.[3]
Fifth Republic (2018–present)
Main article: Partido Federal ng Pilipinas
On April 30, 2018, a group sympathetic with President Rodrigo Duterte, initiated move to promote federalization of the Philippines as Partido Federal ng Pilipinas (PFP).[4] On June 25, 2018, Lawyer Jesus "Jayvee" Hinlo was elected as president,[5] former generals Abubakar Mangelen as Chairman and Thompson Lantion as secretary general[6] and the new group filed for accreditation as a political party. The Commission on Elections accredited the party on October 8, 2018.[7]
On October 17, 2018, the party fielded three senatorial candidates in the 2019 midterm election namely Maria Socorro Manahan, Elmer Francisco, and Diosdado Padilla.[8] It also fielded candidates in the local elections as well.[9]
^ Cullinane (1989), p. 64
^ Nohlen, Grotz and Hartmann (2001), p. 185-230
^ Steinberg (1997), p. 135
^ http://www.dwiz882am.com/index.php/binuong-partido-federal-ng-pilipinas-pormal-nang-inilunsad/
^ http://www.visayandailystar.com/2018/June/25/topstory7.htm
^ http://www.ndb-online.com/june2518/hinlo-heads-partido-federal-ng-pilipinas
^ "Partido Federal ng Pilipinas , pormal nang inilunsad sa QC".
^ "LIST: Senate hopefuls who filed COCs for the 2019 midterm polls".
^ "Sign of humility". Manila Standard.
Cullinane, Michael (1989). Ilustrado Politics: Filipino Elite Responses to American Rule, 1898-1908. Ateneo de Manila University Press. ISBN 978-971-550-439-3.
Christof Hartmann, Graham Hassall, Soliman M. Santos Jr. (2001). Dieter Nohlen, Florian Grotz and Christof Hartmann (ed.). Elections in Asia and the Pacific Vol. II. Oxford University Press. pp. 185–230. ISBN 0199249598. CS1 maint: uses authors parameter (link)
Steinberg, David Joel (2000). The Philippines: a singular and a plural place. Westview Press. ISBN 978-0-8133-3755-5.
Political parties established in 1900
Defunct political parties in the Philippines
1900 establishments in the Philippines


On Martin Luther King day we had a break from the rain, so I decided to venture out to the coast. These photographs are of the surprize that awaited me, a beach covered with foam! It reminded me if the diamond Ice beach in Iceland, but instead if icebergs floating they were giant pieces of foam. This is McClures beach along the coast of northern Marin County. Crystal clear skies after all of the rain, Magical.


Scott Evans - voice, guitar.
Kowloon Walled City is a band who have a dedicated and loyal fan base including ourselves at Sludgelord. Their blend of hard-hitting dirge infested Sludge Metal mixed in with Harsh Noise Rock has seen them receive praise from the underground press and fans alike.
Ever since, they released their debut EP – Turk Street in 2008 and subsequent debut album in 2009 – Gambling on the Richter Scale. Kowloon Walled City showed the world that they were not afraid to show life how it really is. Bleak, Mean, loud and angry just like their music.
Well 3 years after their brilliant debut album, Kowloon Walled City is back with a vengeance. Their new album – Container Ships – features some of their finest work to date.
Newly signed to Brutal Panda Records, Container Ships feature Kowloon Walled City most creative work yet.
First track – The Pressure Keeps Me Alive – starts with a more restrained Kowloon Walled City than ever before. The lo-fi guitar riff setting the scene that sounds fresh but vaguely familiar at the same time. Wait around the 2nd minute before vocalist Scott announces to the world – "Can you take it slow" - The answer on this heavy pounding track is a resounding NO. Kowloon Walled City does not care what you think. They play slow-pace/mid-tempo riffs full of anger and passion.
Kowloon Walled City might have lost a bit of their rough DIY edge to their music from previous releases but it is great to hear the band louder, clearer and angrier than ever.
This track is only the start of a more refined Kowloon Walled City. This band is ready to stake their claim as one of the best bands of Sludge Metal/Noise Rock. And there is nobody going to stop them on this form.
Up next is one of the album's stand out tracks – 50s Dad – A 3:27 minute track that features sublime angry based lyrics and vocals from Scott. This is where the rest of the band shows their talents as well. The interaction from the band is intense. The drums and duelling guitars give 50s Dad a life of its own. The lyrics providing a bleak story that sounds like a personal history lesson from this great band. It is awe-inspiring stuff. A personal history lesson you will always be happy to be listening too.
50s Dad shows what superb underrated songwriters Kowloon Walled City actually are.
Beef Cattle is more familiar Kowloon Walled City territory. Blending harsh sludge rock vibes with added grizzled noise rock landscapes. The drumming is simply immense here. Adding an extra layer of authority to proceedings. It feels like the vocals and guitars were built around the drums on this track, as they are the major driving force here. But Kowloon Walled City do have another social tale of disharmony in the ranks to tell.
Up next is the epic 7:11 minute title track - Container Ships. This is a track where Kowloon Walled City show the world what they are now made of. This has a slight Post-Metal edge to it. The way it starts building up the atmosphere with slow-paced Sludge based guitars and intricate drumming. You know with this being Kowloon Walled City the fireworks will eventually kick off. Believe me they do. But enjoy the instrumental ride before the 2:30 minute when Scott kicks this song into life.
Scott is not just singing to you. He is outlining a statement of intent to the entire world. They are telling you what is wrong with the world.. This t rack is a song full of passion and determined anger that features Kowloon Walled City best lyrics to date. They were written for a purpose and it is a song with a thought provoking message attached. It is up to the listener to figure this out for themselves.
Other tracks such as Cornerstone and Wrong Side Of History carry on the bleak and unsettling tales of modern life with more down-tuned riffs to shake your fragile mind to. Both tracks have sublime riffs that will leave you breathless. It does for me every time I listen to them. It takes this album into the realm of class status.
Last is the almost 9 minute epic – You Don't Have Cancer – a track that is possibly Kowloon Walled City finest work to date. A haunting tale with beautiful atmospheric Sludge guitar riff matched with the creative intensity of sublime noise rock driving it through. Scott paints an eerie picture with his emotionally charged vocals. I don't know if Scott is speaking from experience but this is a gut-wrenching conclusion to a collection of outstanding tracks.
Kowloon Walled City have always been a social conscience band but they take this part of their music onto another level.
They have delivered a truly astonishing album. This should hopefully take this band to the next level as they truly deserve their shot at the big time.
The album is expertly produced and one that shows off Kowloon Walled City talents to hard-hitting brilliance. The album will leave you wanting more. My only complaint is – We might have to wait another 3 long years before their next album. And that is too long not to hear from these extraordinary Sludge Rockers.
We at Sludgelord rate this album not only as Kowloon Walled City best work to date but possibly one of 2012 best offerings to date as well.
This is a must have record you should all own when it's released on Dec 4th 2012 on digital and physical copies on Brutal Panda Records.


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goodreports.net
Canada's Premier Independent Book Site
A Rage for Order, America's War for the Greater Middle East, and Black Flags
A RAGE FOR ORDER: THE MIDDLE EAST IN TURMOIL, FROM TAHRIR SQUARE TO ISIS
By Robert F. Worth
AMERICA'S WAR FOR THE GREATER MIDDLE EAST
By Andrew J. Bacevich
BLACK FLAGS: THE RISE OF ISIS
By Joby Warrick
There was a time, and that not long ago, when people had at least a general idea of what was happening in the Middle East. Whether you were for or against the invasion of Iraq, anyone could follow the latest developments in the news and consider him or herself reasonably well informed on the situation.
In comparison, the chaos that has followed the so-called Arab Spring (a violent aftermath inevitably dubbed the Arab Winter) has resulted in a situation practically incomprehensible to anyone but an expert. There are, for example, over half-a-dozen major players – foreign and domestic – fighting within Syria, while elsewhere along the region's arc of instability the story is much the same. Who is fighting whom now in Yemen? Or in Libya?
At the end of his magisterial chronicle of the decades-long story of America's War for the Greater Middle East Andrew J. Bacevich looks at the Fourth Gulf War (broadly, the current struggle against the Islamic State) and sees it as having given "new meaning to the term convoluted." In A Rage for Order, Robert F. Worth's attempt to explain these convolutions, the situation in Yemen is likened to "a pane of glass shattering into ever-smaller shards." And there's no putting that broken window back together again.
You'd need a scorecard just to keep track of the changing names. The Jordanian terrorist leader Abu Musab al-Zarqawi began life as Ahmad Fadil al-Khalayleh. Zarqawi, whose story is told in Joby Warrick's Black Flags, was radicalized in a Jordanian prison, ran away to join al-Qaeda in Afghanistan, returned home and started a terrorist group called Jund al-Sham, went back to Afghanistan, and then joined a group called Ansar al-Islam in Iraq (sometimes referred to as al-Qaeda in Iraq). Later he set up his own jihadist organization called al-Tawhid wal-Jihad. This would morph, eventually, into the organization now known as ISIS, ISIL, DAESH (these were all acronyms), or just Islamic State.
This confusion of names has some significance. If there is a Fourth Gulf War being fought against the Islamic State, who exactly does that label include? Does anyone really know?
Even the traditional split between Shia and Sunni Islam (with their leading state backers, Iran and Saudi Arabia respectively) isn't very helpful. As with most wars of religion, religion isn't as big an issue as it at first seems. Cross-sectional alliances of convenience come and go. And terrorism isn't about religion as much as it's about political ends anyway. Beyond these immediate ends one can glimpse deeper regional dysfunctions that have been at work now for over half a century: economies based on oil; large populations of young people with little in the way of opportunity (when Worth describes how, in Tunisia, "crowds of young men hang around all day in cafés, watching sports on TV and smoking" you know something bad is about to happen); a history of corrupt, authoritarian government; mass migrations of the dispossessed; and even the effects of climate change.
The Arab Spring was a time of hope, but seems now to have been a turning point when the Middle East didn't turn. Those deeper dysfunctions I just mentioned weren't going to be remedied overnight. And so, as Worth reports:
Five years after the outbreak of the Arab Spring, its original message appears to have been wholly reversed. The demands for dignity and civic rights have given way to conflicts that loosened the very building blocks of social and political belonging. The protesters who chanted for freedom and democracy in 2011 had found nothing solid beneath their feet, no common agreement on what those words meant.
Or, as W. B. Yeats put it in his poem "Nineteen Hundred and Nineteen," his anthem of political disillusion:
O what fine thought we had because we thought
That the worst rogues and rascals had died out.
O but we dreamed to mend
Whatever mischief seemed
To afflict mankind, but now
That winds of winter blow
Learn that we were crack-pated when we dreamed.
We, who seven years ago
Talked of honour and of truth,
Shriek with pleasure if we show
The weasel's twist, the weasel's tooth.
So long to the rule of law and civil society. Hello "dragon-ridden days" and "Violence upon the roads."
Worth covered the Middle East during these years for the New York Times, though he never seems to have had a high opinion of the place. Of Syria he writes:
I had been to Syria many times in the years before the revolution. I loved it the way you love an old abandoned junkyard, full of undervalued rusty relics that no one else has discovered. It was dim and depressing, with its collapsing old markets and decaying French mandate architecture, its medieval tunnels and dark silent bars, its dead cities full of crumbling stones and empty, lichen-clad cisterns.
And of Egypt:
I had been living in the Middle East on and off for more than seven years, and Cairo was a place that made me almost physically sick with its atmosphere of fatalism and decay.
Perhaps some of this is coloured by what came after. One senses a high level of frustration on Worth's part at the collapse of the Arab Spring's promise. His exasperation, however, is in part aggravated by the narrowness of his focus. The current situation is very much the product of long-term forces that were never going to respond to a quick fix, and A Rage for Order does not take a historical perspective. In addition, the focus is narrowed even further by political blinkers. "I have little to say about the role of the United States and other Western powers [in the collapse], because I believe it was mostly secondary," he tells us up front in his Introduction. Nor is much said about Israel. The crises in countries like Syria, Libya, Egypt and Yemen are primarily the result of "indigenous" forces.
However much one may agree with this point of view, it makes A Rage for Order a nice complement to America's War for the Greater Middle East, which takes a much wider view (the war in question begins in 1980 with Operation Eagle Claw, which was the failed attempt to free the American hostages in Iran), and which exclusively addresses America's involvement in the region.
If Bacevich has a recurring theme it is the incoherence of American foreign policy during this period, which is something that came about largely as the product of shifting domestic political considerations. In a nutshell, the question "Why are we fighting over there?" has never been addressed because Americans haven't wanted an honest answer. In his opening paragraph, Bacevich cuts to the chase:
From the outset, America's War for the Greater Middle East was a war to preserve the American way of life, rooted in a specific understanding of freedom and requiring an abundance of cheap energy. In that sense, just at the American Revolution was about independence and the Civil War was about slavery, oil has always defined the raison d'être of the War for the Greater Middle East. Over time, other considerations intruded and complicated the war's conduct, but oil as a prerequisite of freedom was from day one an abiding consideration.
Such directness is surprising for its candor. Obviously Bacevich is critical of America's now longest war, but, a former military man himself, he is less critical of the military than the many recurring failures in political leadership there have been. The army won battles, but not wars; tactical success was betrayed by strategic failures. Nevertheless, a banner announcing victory, or some variation on "mission accomplished," was necessary to sell the war politically back home. Americans were being lied to, but this was just the nature of democratic politics. The people were physically and mentally insulated from what was happening on the other side of the world, and wanted to stay that way. In maintaining this state of blissful ignorance the media were happy to oblige.
American culpability for the present mess is a question of degree. With power comes responsibility. Out of incoherence, chaos has blossomed. There are some who have argued that chaos was America's goal all along, as it frustrated any attempt at unifying the region under a nationalist strongman, but Bacevich won't go that far. Instead he is willing to blame mistaken policies that created negative feedback loops. Even success could lead to failure, as every illusory victory provided a quick political hit. Kicking the "Vietnam syndrome once and for all" may not have been such a good idea, as that had at least held American aggression in check and provided some restraint on the use of force. In comparison, putative success in Afghanistan would lead to "a raging bout of victory disease" that "made [the U.S.] stupid." "Here was an indication of what the passing of the Vietnam Syndrome portended – a heedless absence of self-restraint, with shallow moralistic impulses overriding thoughtful strategic analysis." War had become a fix to boost poll numbers, and little more.
Bacevich's book is essential reading: a thorough and clear-headed look at its subject, but one that should be read in conjunction with Worth's reporting on the ground for a more rounded picture. As noted, the two complement each other nicely. A third book, Joby Warrick's Black Flags offers up yet another perspective, the biographical, in providing a study of the short, violent life of Abu Musab al-Zarqawi.
Bacevich's approach is less concerned with individual personalities, seeing such a focus as typical of America's mistaken thinking: "mistaking symptom (terrorism) for disease (profound political and social dysfunction exacerbated by ill-advised U.S. policies." The same message, however, is also delivered by Warrick, where the point is made that despite al-Zarqawi's leading role in the rise of ISIS, his death did little to change facts on the ground. The final sentence of Black Flags signals the ongoing, indeed endless nature of the struggle: "The next morning, with fresh bombs attached to their wings, they [Jordanian fighter jets] would head north to attack again." No closing curtain. No "The End."
That's not very upbeat, but then what is there to be optimistic about? As I write this review both of the two presumptive major party nominees to become the next president of the United States are far more hawkish than the outgoing Barack Obama. In Israel the government has taken an even further turn to the right and there is no longer any pretense of a "peace process." There is armed conflict ongoing in Iraq, Syria, Yemen, and Libya. Egypt has installed a new military leader, perhaps even more corrupt than the last. This morning I watched two former American military men on CNN debating foreign policy, and offering contrasting yet equally depressing points of view. The one insisted that everything is fine in the Middle East and we just have to be patient. The other wanted to see an increase in the use of military force in order to do "whatever it takes" to get results.
Change is not an option. We should expect to see more of the same.
Review first published online June 9, 2016.
Author Alex GoodPosted on June 9, 2016 June 18, 2017 Categories Reviews -- Non-fiction
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To best understand the game of water polo, John Tanner believes it is imperative to look at the game with a multi-faceted perspective. This includes seeing the game through the eyes of a referee, coach, and player. The goal of this four-part presentation is to create a clear understanding of the game that benefits players, coaches, and spectators along with sharing insights and strategies.
Unlike other sports where the whistle indicates a game stoppage, in water polo the whistle indicates continuation of the game, and the whistle pattern indicates both the infraction and how to continue play. In the pool, Coach Tanner defines and demonstrates examples of the following fouls: Ordinary, Exclusion, Penalty, and the Offensive Push Off foul. The detailed explanation Tanner provides coupled with player demonstrations of each of these foul situations--including the whistle pattern for each-- provide a very clear understanding of how these rules effect the continuous play of the game. Invaluable information for players, coaches, and spectators!
Coach Tanner engages 3x Olympian Brenda Villa in an information exchange regarding styles of play throughout the world. Both Tanner and Villa share their experiences with these different styles and what challenges these styles create to both playing in or playing against. Discussion includes the importance of advanced planning at any level to be prepared for teams that offer unique challenges.
This segment offers a look at understanding tactics of the game. Tanner and Villa diagram and discuss the offensive and defensive strategies for a variety of systems. Tanner first shares his numbering system and proceeds to look at a variety of front court attack and defend strategies. Tanner and Villa present specifics on how to successfully attack and defend and offer invaluable nuances from their experiences as both a coach and a player.
Tanner and Villa again look at tactics and strategies for defending and attacking in power play situations. Villa specifically details strategies for a high school level or lower level team that offers the best offensive and defensive tactics for that level of play along with the pros and cons of various power play strategies.


text:
Q: Query for select items where time after 12 O'clock
Select all VisitNo between two days which are arrived after 12o'clock at noon

A: Try like this,
SELECT VisitNo
FROM   <table_name>
WHERE  EXTRACT(HOUR FROM CAST(ArrivalDate AS TIMESTAMP)) >= 12;

redpajama_set_name: RedPajamaStackExchange


There are 26 letters he can use to make any 2 letter combination. Which means the total number of possible combinations is 26² = 676.
He will have to try 676 combinations before getting the right one. The time he needs is 676 × 5 = 3380 seconds which is less than an hour. Therefore he will crack it in time just before the guard comes.
Suppose the president has been a bit smarter and changed it to a 4 letter password will he make it now? Possible combinations is 26⁴ =456976. The time he needs now is 2,284,880 seconds (634 hours). Clearly he just won't be able to search through the entire space of possible passwords within the hour.
The blind watchmaker also known as natural selection acting on the population requires variation to work. The source of the majority of variation comes from genetic mutations. It is random in that, it is unguided and blind, an error that occurs during DNA replication. DNA consists of a sequence of different nucleotides with each group of three nucleotides representing one amino acid. Proteins consists of a sequence of amino acids. Amino acids is to proteins what letters are to words. Each protein has a unique function determined by its unique sequence of amino acids. Amino acids can link up to form proteins of any length. Proteins have three structures. Primary structure, secondary and tertiary. The tertiary structure is the three dimensional arrangement of amino acids, called a fold, it is what gives proteins their biological functions. Proteins perform various functions such as catalyzing specific reactions, cell signaling as well as part of molecular complexes such as spliceosome, ribosome, and polymerase.
The 3 dimensional structure of a protein gives it its unique function. For example replacing one amino acid in the hemoglobin protein causes it to lose its stable shape and this causes sickle cell disease. The mutant protein is unable to fold properly and therefore will not function. Not all protein sequences are able to form stable folds. Similar to how not all combinations of letters will produce meaningful words.
Figure 2: Primary, secondary and tertiary structure of proteins. Tertiary structure (protein fold) determines the biological function.
New organisms, require new physiological systems such as respiration, which need new organs, which means new tissues, new cell types and new proteins. The origin of new species must atleast begin with the origin of new functional proteins.
Suppose we take a protein consisting of a chain of 150 amino acids, how many different possible sequences are there? There are 20 different types of amino acids used by amino acids which means: possible sequences is =1.4 × 10195 To put this number into perspective – compare it to the total estimated number of individual organisms to have ever lived – which is estimated to be 1043. This value sets an upper limit on the available resources that random mutations have. If a search cannot be successful with this upper limit then it could not have occurred during the history of life. Clearly this is an astronomical number but fortunately random mutations do not have to search through the entire sequence space to find a functional protein.
Figure 3: Fitness landscape in sequence space.
These figures illustrates the fitness landscape concept and how random mutations must randomly search through the space to find functional/fit proteins. Each point on the landscape represents a different protein sequence. The mountain peaks represent the most functional/fit sequences. The low flat parts of the landscapes represent non-functional sequences. The crucial question is the ratio of peaks to flat sequences. Random mutations must "blindly search" through the sequence space for functional peaks.
(B) This figure shows a rugged landscape where functional proteins can get trapped in smaller peaks before reaching the highest peak. (C) Ideal fitness landscape where each point mutation leads to a higher and fit protein. If the landscape is rugged then incremental, one step at a time mutations will not find the highest peak but will get trapped in low fitness valleys. If the landscape is a smooth upward hill – then one step at a time mutations can slowly find the peak of the landscape.
What kind of landscape do proteins have? Is it rugged or smooth?
What is the ratio of functional proteins to non-functional proteins in the protein landscape?
Douglas Axe conducted an experiment to estimate what the ratio of functional folding protein sequences is in comparison total sequence space.
The authors evaluate how many proteins are required to find a functional AroQ class chorismate mutase (CM). Mutase are enzymes that are in the isomerase class – they are used to catalyze reactions where the shifting of a functional group in a molecule to a different position in the same molecule is required. They say, "Genetic selection was used to explore the probability of finding enzymes in protein sequence space…This study provides a quantitative assessment of the number of sequences compatible with a given fold and implicates previously unidentified residues needed to form a functional active site". The study then concludes, "Extrapolating from our data and from modest sequence constraints on interhelical turns (23, 28–30), we can estimate that if every position in the protein had been randomized, a library of 10²⁴ members would have been needed to obtain AroQ mutases." This means that for every 10²⁴ proteins only one will be a functional AroQ mutase enzyme.
Researchers conducted an experiment to find the protein fitness landscape of a particular protein. They randomized a section of the protein (139 amino acids), specifically the D2 Domain section which is crucial for phage infection. They then estimated how large a library (number of different sequences) would be required to find a protein with a fitness level equal to wild type protein (naturally occurring).
Their results indicate that adaptive walking or step by step mutations would be able to climb the fitness landscape up to a certain fitness level indicated of 0.4. The wild type fitness (the actual protein activity found in organisms in the wild) is indicated as 1. The landscape is smooth and single point substitutions can climb up the hill. But above fitness level of 0.4 the landscape becomes rugged and fit sequences become considerably rare. They estimate to reach a peak fitness of 1; it would take 10⁷⁰ different sequences and 35 mutations from the bottom to the peak.
In other words there is one protein with a peak fitness of 1 per 10⁷⁰ proteins. They conclude that a Darwinian step by step mechanism would not be able to find the wild type phage due to the large protein sequence space required to search through and that 35 mutations would be required. Therefore they think that homologous recombination was the mechanism used by nature to find wild type phage protein.
Figure 6: Experimental and theoretical (cytochrome c) results of protein fitness landscapes of different proteins. Values represent the total number of non-functional proteins per functional protein. So for the beta-lactamase domain – 10⁷⁷ proteins must be searched through in order to find one functional protein.
The fitness landscape of proteins can be rugged which means that darwinian point mutations are not sufficient for finding the peak of proteins.
Protein sequence space is populated by non-functional proteins.
In part 2 I will continue looking at more in depth evidence for the rarity of folding and functional proteins in total sequence space.


VIDHYUT SALE CORPORATION is a total solutions provider in the field of Electrical & Automation. The company experience in field of L.T. Electrical System Design, Manufacturing, Erection & Maintenance. With the idea to provide total electrical solution to customer, It has gradually accoutered with the ideal of quality product and satisfactory services during this period. It has been our constant endeavor to provide the best in whatever we pursue. Our diligent engineering team has already executed a number of projects in the field of electrical and automation.
We ensure that our customers get the best of services and support at their doorstep. We shall be honored to be a part of your systems development process right from the beginning to serve you with the right mix of products that can save your time and energy, while providing you with the best technology in the world.
Our expertise is to serve the customer with the right solution at the right time at their doorstep within their budget and guaranteeing after sales support for uninterrupted availability of the system. Our team is trained and made capable enough to select the right components of your solution and integrate those so as to serve you with the complete system.
We have provided our services to reputed private companies and government Organizations. In very short span of time, Safeline has made a niche for itself even in selling a number of AC Drives and PLC Systems to our satisfied customer base.
We are certain that as we have served the industry in past, we will continue the same incorporating modern technology and ideology.


VitroGel 3D can be used for 3D cell culture by simply mixing with cells. The hydrogel matrix supports cells to grow as 3D colonies over time. Drugs or other chemical compounds can be added to penetrate into hydrogel system for screening.
VitroGel 3D can be used to coat the substance that cells grow on. The different stiffness and texture of the substance might lead to different cell behaviors. Also, as time goes on, cells might move into the hydrogel matrix for invasion/migration study.
By mixing the hydrogel solution and cell suspension (or other ionic solution) in a proper ratio (recommend 4:1 v/v), an injectable hydrogel can be formed and used for xenograft, drug delivery, bio-printing, microarray, etc.
Additionally, the hydrogel properties and preparing protocols can be manipulated for different physical/chemical characteristic and gel formation times. The concentration of hydrogel solution can also be adjusted for different hydrogel strengths. Multiple applications can be done with these flexibilities.
For customized products or special applications, please contact us!


Having a great lawn is essential and choosing the right one can be difficult for you if you do not know. If you live in a place that experiences lots of harsh climatic conditions, it is important that you ensure that you get to know how you can be able to ensure the survival of the normal grass, you need sod. There are some of them that will often make you enjoy a landscape that is amazing as this is essential for you. Therefore when you decide to buy sod, don't choose any one of them, you will need to consider these three items when you are choosing the quality one.
You need to know how soil has been consistent in coming up with the sod as this plays a great role in choosing the right one. You need to know that there are a number of things that will help you along the way and being able to choose the right one will keep your business able to focus more on beauty. In case it happens to be much, there are high chances that you would be having the grass between too much sod and this would not work for you right on the yard. It is important that you get to know that having the right amount of soil will ensure that you enjoy grass survival and this is very important for you.
Never make mistakes of buying sod before you are sure that it is fertilized enough to be uprooted and transferred to your lawn. Note that there are times where drought will come, and if your sod had not been well fertilized, then it will not survive the hardship that comes with insufficient fertilization. Also, if you realize that your grass starts changing its original color to other colors like yellow, then it might be an implication that its sod was not well fertilized. The stress of the sod being transplanted and uprooted to be taken somewhere else can only be withstood by sod which has enough fertilizer. You can only expect healthy and green lawn if the sod you invested on was well fertilized.
About maturity, you also do not wish to assume that you have a mature sod. If you do not see quality grass when you look at your lawn, then it could be that you were very careless when choosing mature sod. Note that the immature sod has not yet found its base on earth and that is why it would be struggling to find where it belongs. If you are still wondering how you can find out how mature your sod is, here are some great tips for you. For you to know the maturity of sod, look at its dense and also how the color blends.


2 What is a QMS?
Quality management is vital to the success of an organisation. It enables it to deliver products and services that meet both customers' requirements and regulations, protecting its reputation while reducing costs and driving improvement. It also helps an organisation ensure it is operating in the most sustainable way.
Quality planning: This ensures that quality requirements are addressed throughout the product and service lifecycle.
Quality control: This focuses on process outputs to ensure that standards are actually met.
Quality assurance: This gives confidence that standards and requirements are being met.
Quality improvement: This process is informed by all of the above activities and the requirements of the business.
Failure in the quality of a product or service.
Failure to deliver the product or service on time.
Failure to deliver the product or service to cost.
Failure to identify trends in customer needs.
Failure to meet legal or regulatory requirements.
Failure of partners and suppliers.
Loss of customer data or property.
Superior customer satisfaction and loyalty.
Identification and elimination of waste.
Employees committed to quality and improvement.
Plan: Establish the objectives and processes necessary to deliver results in line with customer service requirements and company policies.
Check: Monitor and measure processes necessary to deliver the results.
Act: Take action and continually improve performance.
The QMS helps an organisation to plan for success, and measures and reviews the effectiveness and efficiency of processes to inform improvement. A major misconception is that adopting a QMS demands a large amount of paperwork. Although certain documents are required, the modern QMS can be lean and agile, and should be developed to suit a business in terms of size, complexity and risk.
The ISO 9000 series of standards is the main set of international standards that apply to the management of quality systems. It includes ISO 9001, the standard against which organisations can achieve third-party certification for a QMS.
A statement demonstrating that an organisation's quality policy is driven by senior management. This may cover: identification of the customer's needs; support and standards of performance for subcontractors and suppliers; a focus on prevention rather than detection; measurement of satisfaction among customers and the supply chain; performance measurement, review and improvement. Leadership also requires senior management commitment to ensuring that the QMS delivers the intended outcomes through communication of the policy, allocation of responsibilities, providing adequate training and resources, and so on.
Taking into account the commercial context and customer requirements, the QMS will establish "who, what, how and when" the organisation will address risks and opportunities, avoid undesirable effects and achieve desired outcomes.
Establishing the resources required to deliver on the quality policy and objectives throughout the organisation and supply chain, including communicating the different roles of people within the organisation in delivering the requirements of the QMS.
Planning, implementing and controlling internal and outsourced processes to design and deliver products and services.
Setting out how work is to be monitored, measured, analysed and evaluated, to establish that the QMS is suitable, adequate and effective. Inputs may include audits, metrics, schedules, non-conformities, complaints, monitoring and measurement results.
Dealing with instances of undesirable results and identifying ways to prevent future occurrence. This also includes considering changes in the internal and external environment and how these future risks and opportunities are to be addressed.
Certification can open new markets where it is a customer requirement, as it is among many public and private sector organisations.
Certification reduces the number, and therefore the cost, of supplier audits. Instead of multiple audits, it involves a single audit, and provides a certificate that is universally recognised by customers (depending on their own policies).
Certification provides an organisation with an independent view of its QMS performance and its capability to consistently meet customer and regulatory requirements and to continue to improve.
Certification can provide a level of confidence in the capability of an organisation's own supply chain to consistently meet its requirements, as well as reducing the cost of the oversight audit that is required.
The Chartered Quality Institute promotes "accredited certification", which means that the third-party certification operates under the oversight of the United Kingdom Accreditation Service, in the UK, or a similar national accreditation body in other territories. Achieving non-accredited certification may mean that an organisation's certified status is not recognised by some customers and may not necessarily comply with international standards.


text:
Nosopsyllus aralis är en loppart som först beskrevs av Anatol I. Argyropulo 1946.  Nosopsyllus aralis ingår i släktet Nosopsyllus och familjen fågelloppor.

Underarter

Arten delas in i följande underarter:

 N. a. aralis
 N. a. tschu

Källor

Fågelloppor
aralis

redpajama_set_name: RedPajamaWikipedia


I hope she doesn't get a bad grade.
Published on October 12, 2017 by Jonny Aleksey.
Dutch and Phillman leave to talk about Val as she struggles with her fears.
Webcomics. Superhero. Fantasy. Drama. Book 3. Page 13. All Ages.


Looking for a new location or an additional location for your business? Check out the officesat Clock Tower in New Windsor. Excellent Visibility and High Traffic count, over 20K Cars per day direct on 9W. Class A medical tenants in place already.Only twosuites left totaling 4000 sq feet. One space is an open floor concept alreadyand the other is a turn key medical office perfect for pediatrics, Neurologist, cardiologist, etc.Excellent opportunity! Price per sq foot can be reduced but will depend on amount of square footage and term.


text:
Juan Fernando Arango Sáenz (Maracay, 17 mei 1980) is een Venezolaans betaald voetballer die bij voorkeur als aanvallende middenvelder speelt. In januari 1999 debuteerde hij in het Venezolaans voetbalelftal.

Clubcarrière
Arango begon met voetballen bij Club de la Universidad Central. Hij debuteerde als prof voor Nueva Cádiz FC uit de Venezolaanse tweede divisie. Via Zulianos FC en Caracas FC kwam Arango in 2001 bij het Mexicaanse CF Monterrey. Vervolgens speelde hij in Mexico bij CF Pachuca (2002/2003) en Puebla FC (2003/04). In 2004 tekende Arango bij Real Mallorca.

Tijdens de wedstrijd van Real Mallorca tegen Sevilla FC op 20 maart 2005 raakte Arango geblesseerd door een overtreding van Sevilla-verdediger Javi Navarro, die voor de charge een gele kaart kreeg. Arango viel door een elleboogstoot van Javi Navarro op de grond en lag trillend en brakend buiten bewustzijn op het gras. Arango dreigde te stikken doordat hij zijn tong had ingeslikt, maar dankzij optreden van de eerste hulp, die een slangetje in de mond van Arango bracht waardoor hij kon blijven ademen, liep het goed af. Arango moest direct naar het ziekenhuis. Daar werd een hersenschudding en een gebroken jukbeen geconstateerd. Van hersenbeschadiging was geen sprake. Arango keerde binnen enkele weken alweer terug in het elftal van Real Mallorca en met enkele doelpunten had hij een aandeel in de handhaving van de club in de Primera División.

Hij tekende in juli 2009 een driejarig contract bij Borussia Mönchengladbach, dat hem overnam van RCD Mallorca. In 2014 en 2015 speelde hij in Mexico voor Club Tijuana, ruim vijfenveertig competitiewedstrijden, waarin hij elf doelpunten maakte. Op 29 januari 2016 tekende Arango bij de Amerikaanse club New York Cosmos.

Interlandcarrière
Arango debuteerde op 27 januari 1999 in het Venezolaans voetbalelftal in een oefenduel tegen Denemarken. Hij viel in die interland na 61 minuten in voor Luis Vera. In 1999, 2001, 2004, 2007, 2011 en 2015 nam hij met zijn vaderland deel aan de strijd om de Copa América.

Op 9 september 2015 zwaaide Arango af bij het elftal, na 129 interlands en 23 interlanddoelpunten. Zijn finest hour met de nationale ploeg beleefde hij in 2011, toen hij zijn vaderland naar de vierde plaats leidde bij de strijd om de Copa América: de beste prestatie ooit van Venezuela in de historie van het Zuid-Amerikaanse kampioenschap.

Bondscoach Noel Sanvicente prees Arango bij diens afscheid. "Als we het over Arango hebben, hebben we het over de beste voetballer die Venezuela ooit heeft gehad", zei de coach over de speler die in Europa naam maakte bij Real Mallorca (49 goals in 191 duels) en Borussia Mönchengladbach (31 goals in 175 duels).

Clubstatistieken

Zie ook
 Lijst van spelers van CF Monterrey
 Lijst van spelers van het Venezolaanse voetbalelftal

Venezolaans voetballer


Bedrooms, Party Room Decoration was posted February 11, 2016 at 11:33 pm by arlo.info . More over Party Room Decoration has viewed by 1261 visitor.
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text:
enum
{
    kSKPSMTPIdle = 0,
    kSKPSMTPConnecting,
    kSKPSMTPWaitingEHLOReply,
    kSKPSMTPWaitingTLSReply,
    kSKPSMTPWaitingLOGINUsernameReply,
    kSKPSMTPWaitingLOGINPasswordReply,
    kSKPSMTPWaitingAuthSuccess,
    kSKPSMTPWaitingFromReply,
    kSKPSMTPWaitingToReply,
    kSKPSMTPWaitingForEnterMail,
    kSKPSMTPWaitingSendSuccess,
    kSKPSMTPWaitingQuitReply,
    kSKPSMTPMessageSent
};
typedef NSUInteger SKPSMTPState;

// Message part keys
extern NSString *kSKPSMTPPartContentDispositionKey;
extern NSString *kSKPSMTPPartContentTypeKey;
extern NSString *kSKPSMTPPartMessageKey;
extern NSString *kSKPSMTPPartContentTransferEncodingKey;

// Error message codes
#define kSKPSMPTErrorConnectionTimeout -5
#define kSKPSMTPErrorConnectionFailed -3
#define kSKPSMTPErrorConnectionInterrupted -4
#define kSKPSMTPErrorUnsupportedLogin -2
#define kSKPSMTPErrorTLSFail -1
#define kSKPSMTPErrorNonExistentDomain 1
#define kSKPSMTPErrorInvalidUserPass 535
#define kSKPSMTPErrorInvalidMessage 550
#define kSKPSMTPErrorNoRelay 530

@class SKPSMTPMessage;

@protocol SKPSMTPMessageDelegate
@required

-(void)messageSent:(SKPSMTPMessage *)message;
-(void)messageFailed:(SKPSMTPMessage *)message error:(NSError *)error;

@end

@interface SKPSMTPMessage : NSObject <NSCopying, NSStreamDelegate>

@property(nonatomic, retain) NSString *login;
@property(nonatomic, retain) NSString *pass;
@property(nonatomic, retain) NSString *relayHost;

@property(nonatomic, retain) NSArray *relayPorts;
@property(nonatomic, assign) BOOL requiresAuth;
@property(nonatomic, assign) BOOL wantsSecure;
@property(nonatomic, assign) BOOL validateSSLChain;

@property(nonatomic, retain) NSString *subject;
@property(nonatomic, retain) NSString *fromEmail;
@property(nonatomic, retain) NSString *toEmail;
@property(nonatomic, retain) NSString *ccEmail;
@property(nonatomic, retain) NSString *bccEmail;
@property(nonatomic, retain) NSArray *parts;

@property(nonatomic, assign) NSTimeInterval connectTimeout;

@property(nonatomic, assign) id <SKPSMTPMessageDelegate> delegate;

- (BOOL)send;

@end


Approximately 700,000 deaths annually are caused by antimicrobial-resistant microorganisms, and the Organization for Economic Co-operation and Development (OECD) predicts that current rates of antibiotic resistance will result in cumulative costs of roughly $3 trillion by 2050. With antibiotic resistance increasing at a startling rate, the need for rapid, precision diagnostics and decision support infrastructure is critical to changing the treatment paradigm and unlocking the economic potential of novel targeted antibiotics.
Global coordination of key stakeholder groups and focus on these activities will help turn the tables on antibiotic resistance over time, sharply improving patient and public health outcomes.


Thank you to Ruth Blankenbaker, CILC, for sending me this article from Morinville, Alberta on a Read Around the Planet connection with one of my schools, Sylvester Elementary. It's a cute write up and the teachers decided to be pen pals after the connection. A common response to Read Around the Planet.
Do you know of any published news articles about RAP connections in your area? Please comment and share!


text:
Home / What You Must Know About ERP For the Small Shop
What You Must Know About ERP For the Small Shop
In the hyper-competitive metalworking business, some job shops with only a few employees still use separate homegrown systems or one very old program that is not very efficient in managing and reconciling their manufacturing and financial operations. They still shy away from ERP because making that transition is just too big of a task, too large of an investment in IT infrastructure on-site and training that is more trouble than it's worth.
But times have changed: With today's cloud-based systems, the upgrade to ERP isn't as challenging as it was before. These new systems don't require full-time IT resources or a costly infrastructure, which can be very attractive for a small shop that wants to lower operating costs and improve efficiency. Cloud-based systems no longer require a hefty IT infrastructure on-site, which can make advanced ERP available to even the smallest of shops. However, to plan for an upgrade, shop owners must consider the factors that are explored in this webinar by Epicor:
The cost of doing nothing: When shops don't implement ERP
What causes ERP projects to fail: Why successful implementation matters as much as the technology itself
Process, timing, cost, sizing and other considerations in starting a selection process
Scott Marienthal has been working with manufacturing companies all over the world for 25 years. Since joining Epicor in 2010, he has focused on assisting larger manufacturing and distribution companies in the Midwest benefit from Epicor ERP. Backed by the most talented team in the country, Scott has seen the Midwest become Epicor's most productive and successful region.
Sonia Haslam is the co-founder of Encompass Solutions, Inc., a Platinum Certified Epicor Partner, founded in 2001. She began her career in manufacturing, working on an ERP implementation. From there she became proficient in small business operations and has grown to take on ever more complex projects, including many for large, multi-national companies. Sonia has been implementing business systems for over 20 years, in a cross-section of process and discrete industries. She is particularly knowledgeable in enterprise-wide integration and the management and support of heavily customized applications. With her depth and breadth of experience, she commits to understanding the client's core competencies and partners with the enterprise to achieve total success, providing solutions that allow customers to remain competitive and on the leading edge of technology.
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Woman needed oxygen after getting stuck in lift at Derriford Hospital
Two people had to be released from the lift
Rom Preston-EllisDeputy Head of Content
A woman had to be given oxygen after becoming trapped in a lift at Plymouth's Derriford Hospital.
Fire crews were called to the hospital after two people reported they were stuck in the lift at 5.39pm.
The patient in need of medical treatment was left in the hands of hospital nurses having been released from the lift.
Derriford Hospital in Plymouth (Image: SWNS Group)
A spokesperson for Devon and Somerset Fire and Rescue Service said: "Two fire appliances from Crownhill attended a lift rescue incident where two females were trapped.
"Crews got to work with small tools to effect a rescue.
Police have already rescued four dogs from hot cars in Plymouth today
"One of the females received oxygen therapy by fire crews once released and duty of care of the ladies was left with a staff nurse."
A spokesperson for Derriford Hospital confirmed that the patients were stuck in the lift for 'a short time'.
Devon and Somerset Fire and Rescue


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Ali twins used $40k in savings to build property portfolio worth $5 million
A PAIR of identical twins from Western Sydney have accomplished the rare feat of buying into the housing market not once, but 10 times over.
AIDAN DEVINE
The Daily TelegraphMay 11, 20178:29am
Mona (left) and Sana Ali own nearly $5 million in property.Source:Supplied
THINK high prices have made it impossible to own property? A pair of identical twins from Western Sydney will make you want to think again.
Sana and Mona Ali, 31, have amassed a property portfolio of eight properties worth roughly $5 million, starting from savings of about $40,000, and claim almost anyone can replicate their success.
Their investments span properties spread across Western Sydney and Brisbane, which they have acquired at a rate of roughly a property a year.
The key to the twins' success was buying properties in areas they could afford, like Blacktown.Source:News Limited
The Pakistan-born twins claim the key to their success was that they focused on cheap properties with high rents that showed the potential to increase in value.
This strategy started with their first purchase: a two-bedroom villa in the Parramatta region, bought in Mona's name for $330,000 in 2009.
Aged 24 at the time, the twins had only recently started their careers — Mona in an accounting role and Sana in IT.
"Sydney prices were considered unaffordable even back then and interest rates were much higher, so we knew it was going to be difficult," Sana said.
"We realised that to just get into the market we'd need to buy at lower prices and get rents that would cover most of our mortgage."
They repeated the strategy for their next property, a unit in Western Sydney's Blacktown region bought in Sana's name.
In both purchases, the twins supplemented their savings of $40,000 (across the two properties) with the First Home Owners Grant, which at the time was available for purchases of established properties.
By 2011, the value of both properties had increased enough to allow the twins to refinance their loans and use their equity gains as deposits for subsequent properties.
This included another unit in Blacktown and, six months later, a three-bedroom villa in a nearby area.
The twins recently started their own property company.Source:Supplied
"We liked areas liked Blacktown because the prices were cheaper but also going up," said Mona.
Their next property was a three-bedroom townhouse in Penrith, bought in 2013, followed by a two-bedroom townhouse and three-bedroom detached house, both in Blacktown.
They then used a combination of savings and further refinancing arrangements to purchase another property near Parramatta, now their residence, and two neighbouring properties in Logan, Qld.
Two of these properties have since been sold but recent valuations of the rest of the twins' homes proved they chose their properties wisely.
Their first property in the Parramatta area has nearly doubled its value since purchase to $630,000, while their three-bedroom house in the Blacktown area went from being worth $430,000 when they bought it to $850,000.
"I think it helped that we had different priorities," Mona said. "We didn't go travelling, even though we wanted to, so it was easier to save."
Being realistic about what they purchase was also a help, according to Sana.
"People need to realise that it's OK to start small," she said. "Your first property doesn't need to be your dream home. Buy somewhere affordable. You can always buy somewhere else later.
"It's about delayed gratification. The holidays and flashy cars don't have to happen today. They can wait until later."
The twins claim they acquired this understanding after first moving to Australia in 2000.
"We went to a private school in Karachi and had a very high standard of living but when we moved to Australia we lived in a low income area … you start to get a (perspective) of what's really important."
The twins' latest move saw them leave Macquarie Group, where both were working, to start a mortgage brokerage, Property Twins, earlier this year. The company aims to assist homebuyers build an asset base.
Originally published asTwins turn $40k savings into $5m
Upper north shore market back with a bang
Price records set to tumble in 2021
COVID-safe apartment sells for around $7.5m
The big trap first-home buyers must be wary of
DIY jobs Aussies are all chasing


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Q: Insert, get id and insert at the same time I have two PHP functions that have to be executed at the same time. I need to use two different functions because, for example, I create a course in my app and at the same time I add multiple homework for my students. Here's my simplified code:
function createCourse($courseName) {
    global $mysqli,$db_table_prefix;
    $stmt = $mysqli->prepare("INSERT INTO courses (name) VALUES (?)");
    $stmt->bind_param("s", $courseName);
    $result = $stmt->execute();
    $stmt->close();
    return $result;
}

function addHomeworkToCourse($homeworkDescription) {
    global $mysqli,$db_table_prefix;
    $course = "13"; // Here comes the problem: how do I get the ID inserted in the previous function
    $stmt = $mysqli->prepare("INSERT INTO homework (course, description) VALUES (?, ?)");
    $stmt->bind_param("is", $course, $homeworkDescription);
    $result = $stmt->execute();
    $stmt->close();
    return $result;
}

And the form to create a course and add some homework to it in the same page:
createCourse("Maths");
addHomeworkToCourse("Resolve this equation"); // Add some homework to "Maths"

Thanks for your time! (Please note that I'm not an expert PHP, MySQL and English)

A: $id = createCourse("Maths");
addHomeworkToCourse($id, "Resolve this equation");

have the createCourse return the id of the course with last inserted id.
php.net/manual/en/mysqli.insert-id.php
This would also make the add HomeworkToCourse method/function more robust and able to be used in a variety of situations

A: With mysql you can use the php function mysqli_insert_id (docs) to get the last inserted ID of the course, then you can add the homework to it.


Yesterday, myself and Keith gave ourselves an early Xmas present.
We went up to London to see The Phantom Of the Opera at Her Majesty's Theatre.
We had originally brought front row tickets in the balcony, from previous experience of the show, the higher you are the better view of the special effects you get, yes we have seen it over a dozen times, mostly in Las Vegas.
We were moved by the theatre to what they said were better seats, I guess they did not need to open the balcony up as it was a matinee, and not fully sold out.
The seats we were given were in the second row of the Grand Circle, more expensive, but very disappointing, as you could not see the front of the stage, and with just one person in front of you, if they leaned forward, our view was nearly blocked completely.
So if you intend going, be careful where you actually purchase your seats.
The performance itself was as amazing as ever, thankfully the music overrides the need to actually see the performance.
2 roles were the best we have ever seen, Christine and Carlotta, and I have to mention the orchestra, they do not get as much praise as I think they deserve.
All in all a great day out, but such a shame such a great musical is in a theatre that does not do it justice, mind you it still regularly sells out, just wonder how many people would return if located in a better theatre.
We were obviously spoilt by the Las Vegas show and purpose built theatre, sorry to say the show has now closed in Vegas.
Keith has now got to put up with me singing some of the songs from the show, he says earplugs are needed, LOL.
Not everything you see can really be true, we had a wonderful day out at the Frankfurt Xmas Market, seeing young Jake so excited was great, so many stalls, nearly blew the diet, wonderful donuts, chocolates, cakes, and that was just the sweet items.
Many other stall selling savouries, but they were not as much fun, LOL.
Other stall were selling fancy items, very nice.
Now you might have wondered just how we managed Frankfurt in a day, well we cheated, this xmas market is now on in Birmingham, England, just over an hour from us on the train.
Jakes new hat also caused a few laughs, cheeky chappy.
Our thoughts and prayers are with all our friends in the US and Canada that have been affected by the storm.


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Forecast: Upland bird numbers in Kansas among best in nation
KDWPT
The Kansas Department of Wildlife, Parks and Tourism this week issued its 2018 Upland Bird Forecast, and the outlook is generally pretty solid across the state.
The Kansas pheasant forecast was categorized as being "fair to locally good" this year after Kansas reported the second-highest harvest by state in 2017, though roadside counts indicate a below-average pheasant population this year. Still, the state is set to have one of the top pheasant populations again this fall.
"Winter precipitation was limited this year, resulting in short wheat and concern for nesting prospects," the report stated. "Heavy spring and summer showers greatly improved vegetative cover for nesting, but also limited nest success. Conditions shifted peak pheasant hatch later into June and July. While wheat harvest was delayed, which typically benefits pheasant production, the short wheat limited its usefulness for nesting."
Best areas will likely be in the northern half of the Kansas pheasant range, with areas of high densities also found in central and far southwestern regions, according to the report.
The recorded 2017 bobwhite quail harvest in Kansas was the highest of any state in the country, just above Texas, and though the population is predicted to be down slightly it will still be among the best in the country, the forecast predicts.
"While total harvest has remained well below average due to lower hunter participation, the average daily bag has remained at the best levels observed in 20 years. The bobwhite whistle survey in 2018 showed only a slight decline compared to the 2017′s highest values ever recorded from this survey, which began in 1997."
The report says densities in the eastern-most regions are not as high as other parts if the state, but all regional indices remain near or above their respective long-term averages, with the best opportunities in the central regions, extending east into the northern Flint Hills. Pheasant and quail seasons run Nov. 10 through Jan. 31, 2019, with a youth season Nov. 3-4. The daily bag limit for pheasant is four cocks during the regular season and two during youth season. The bag limit for quail is eight birds during the regular season and four during the youth season.
In the Northern High Plains and Smoky Hill Regions, greater prairie chicken numbers have been stable or even increasing, the report added. The greater prairie chicken early season runs Sept. 15 through Oct. 15 and Nov. 17-Jan. 31, 2019. Hunters are required to purchase a $2.50 Prairie Chicken Permit to harvest the birds, in addition to their regular hunting license.


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Home>Faculty & Staff>Faculty>Hon. William Dreier
Hon. William Dreier
Norris, McLaughlin & Marcus P.A.
Judge Dreier is a member of Norris, McLaughlin & Marcus, Bridgewater, NJ, and is retired Presiding Judge of the Superior Court of New Jersey, Appellate Division. Concentrating his practice on Arbitration, Mediation and Case Management. He is an experienced Mediator and Arbitrator in all areas of civil litigation who frequently lecturers and writes on ADR subjects. He is a member of several AAA panels: Class Actions, Appellate, Large and Complex Case, Wireless Telecommunications, Commercial and Mediation. and ICDR. A, Fellow of the College of Commercial Arbitrators and the National Academy of Distinguished Neutrals, he also has served as an I.C.C. Arbitrator and a Distinguished Neutral for CPR, He is also a Certified Mediator, of the International Mediation Institute and an Accredited Mediator for CEDR (London, UK).
A graduate of Columbia Law School and M.I.T., Judge Dreier is the author of New Jersey Arbitration Handbook, New Jersey Products Liability and Toxic Torts Law, Chancery Practice in New Jersey, and Secured Transactions Under the U. C. C.,each in many annual editions, as well as over 50 published Law Review, Law Journal and magazine articles, and approximately 380 officially reported judicial opinions. He lectured for ALI-ABA for over a decade at many locations nationally; as well as for N.J.I.C.L.E for nearly 40 years, for New Jersey Judicial College for 30 years, and for the New Jersey Law Journal: several times . He was a faculty member at the National Judicial College for eight years, and participated in various law school symposia in NJ and nationally, and was a. Judicial Conference Guest Lecturer in five states.
The judge is a member of the Columbia Law School Board of Visitors (Emeritus) and the Editorial Board of the New Jersey Law Journal. He is the Former Board of Trustees Chair of N.J.I.C.L.E, as is a Life Fellow of the American Bar Foundation;, a Life Member of the American Law Institute, a Master of the Marie L. Garibaldi ADR Inn of Court, and a member of American, N.J. State, and Somerset County Bar Associations. He is a past President of the Retired Judges Association of New Jersey, and has served for 17 years as a New Jersey Supreme Court Judicial Evaluation Commissioner..
Judge Dreier is a recipient of the New Jersey Bar's highest award, the 2008 New Jersey Bar Foundation's Medal of Honor, as well as the 2010 Boskey Award for Excellence as New Jersey's Outstanding ADR Practitioner from the Dispute Resolution Section NJSBA. He received the first annual William A. Dreier Award in 2009 for excellence in and the advancement of Product Liability Law from the Product Liability Section, NJSBA, and the 2015 Lifetime Achievement Award for Service to the Public and Legal Profession by the New Jersey Law Journal, as well as the 1983 Alfred C. Clapp Award for Excellence in Continuing Legal Ed.,from NJICLE. He was named Lawyer of the Year in the field of Arbitration, 2016, (Central NJ Area) by Best Lawyers, and has been listed in the compilations of Chosen as a Super Lawyer and Best Lawyers in America since 2004, and for several years in Who's Who in America.