text:
Cobra Ranch
Cobras, GT40s, and everything in between.
Artwork by Wallace Wyss
The Shelby Mk. V
Shelby Mk V aka The Mangusta
Never heard of it? It reached the U.S. market as the Mangusta.
by Wallace A. Wyss
Carroll Shelby was a quick learner. He learned early on that the Cobra, particularly the leaf sprung Cobra descended from the 1953 A.C. Ace, had peculiar handling. The Cobra chassis was redesigned by Ford for the big block model, but it was never a sophisticated handler; more of a "point and squirt" device.
Once he became involved with the Ford GT40 in 1964, Shelby realized that mid-engined was the way to go. Having the engine between the axis made for a better polar moment of inertia, reducing the time a car takes to respond to turning input.
When the Group 7 cars began to emerge, Shelby wanted to get into it. He had earlier imported some Cooper Monacos, mid-engined cars, from England and had Cobra-ized 289 cast iron V8s installed. These were nicknamed by the press "King Cobras" but were dropped from his racing roster once he became involved with the Ford GT.
ENTER DE TOMASO
Then came Alejandro de Tomaso (from here on, we spell it the American with a capitalized "D"). An Argentine living in Italy, he was infamous for developing one race car after another, often with ingenious ideas but he had a penchant for always going on to the next idea; leaving the last project stillborn with no development.
Around 1962 he did get a mid-engined coupe into production, called the Vallelunga after a racetrack where the prototype in roadster form had some small success. This Ford Cortina-powered car was svelte looking, but handled only marginally, and the power output from a nearly stock engine was far below what it needed to beat Porsches in the same class.
Then in 1965 Shelby had his chief in-house designer, Peter Hall Brock, design a mid-engined car that would be good for the emerging Group 7 class in the U.S. The car had a svelte roadster body, with a mid-mounted V8 and a rear spoiler that finally saw the airfoil that Brock had envisioned for the Cobra Daytona coupe reach fruition. The driver could control the angle of a movable panel in the center of the airfoil so that the amount of download on the rear could be varied.
The car was innovative. Unfortunately the first coachbuilder, Frua, totally screwed up the design, so much so that Brock took the car over to Fantuzzi, who built many a race car, and had a new body designed that was closer to his clay model.
The racing world was awaiting the car and had their appetite whetted when DeTomaso rolled out a mockup of the chassis--a spine frame chassis with the engine connected to central spine, an idea that DeTomaso had reportedly cribbed from a German design of the 1920's called the Rumpler.
Alas two such mercurial temperaments as DeTomaso and Shelby couldn't get along for long—each had a penchant to take the limelight and there was room under that limelight for only one at a time. Plus Shelby had promised Ford he would make more Daytona coupes. The first Daytona had a body hand-hammered out in Los Angeles by Bill Honda, but the bodywork for the next batch was farmed out to Italy, to Carrozzeria Gran Sport in Modena. Once Shelby took the money out of the kitty provided by Ford to make more Daytonas he had none left to pay DeTomaso so DeTomaso glommed onto the race car project and finished it out as a Ghia show car called the 70P.
Whether one ever reached a racetrack is debatable. This writer has seen pictures of one being tested and even pictures of it being raced, but was it a real race, or just a gathering of individuals to watch a car being tested? And how many were made is even debated some 40 years later…maybe two…maybe three. Documenting early DeTomaso prototypes is like trying to catch cats, the history is elusive, and there are no fulltime DeTomaso serial number mavens equal to Marcel Massini is in the Ferrari world.
But DeTomaso never quite threw anything away. Here he had the world's attention with the spine frame and the 70P. Then luck came his way. Ghia had done a design for a rival firm, Iso of Bresso, who made Chevy V8-powered cars. Giugiaro had penned a dramatic mid-engine car that could have been the "little brother" of the big Iso Fidia four seater. But Renzo Rivolta, head of Iso, soundly rejected the idea so there was DeTomaso with a beautiful mid-engined car body design and no chassis to put it on. Wait a minute--what about the 70P chassis? Thus came the Mangusta.
THEN CAME THE MANGUSTA
The DeTomaso Mangusta is one of the most beautiful cars ever to come out of Italy. But it does have its problems.
It had a similar frame to the 70P race car but not quite. Around the perimeter of the floor-pan is tubing of quite a modest size. The body was heavy steel (except for the deck lids, which in some cars were aluminum). The car flexed like crazy.
The engine was a 302 in its American form, not the robust 302 that was in the Boss 302 of 1969 but a weak 302 that was reportedly available as a stationary industrial engine. It was a low revver but at least durable if you kept it below 6000 rpm.
The gearbox was a ZF 5-speed trans-axle similar to that in the GT40, ordered up after the disaster in the '64 season when the Colotti gearboxes packed up whenever they were pushed hard.
One of the main problems of the Mangusta was that the gearbox was put in the same place vis-a-vis the engine as that in the GT40, with the result that it was quite low to the ground. Hit a pothole and you stood a chance of cracking the bell housing which was quite expensive. In the later Pantera. DeTomaso wisely flipped the gearbox around, so that it was a few inches higher off the road which the result less cracked gearbox casings.
The designer of the Mangusta was none other than Giorgetto Giugiaro, then just a very young man with only one other carrozzeria (Bertone) in his resume, but now arguably the most famous car designer in Italy. The car made it from the prototype to production with very few changes, the biggest being the adding of two vents to the rear deck "butterfly" wings in order to vent hot air out of the engine compartment.
Sitting in the Mangusta , one discovers how close the windscreen is to the driver's head. This writer is 6'1" and grew uncomfortable having the windscreen only 3" from his head. So much for a design that looks good from all angles but forces you to accommodate to something arguably dangerous in order to get those good looks.
Today's owners of the 400-odd cars (the general consensus was that 400 coupes were made and one roadster prototype ) sometimes defend it by saying the tires of the time were to blame. Others spend the development money DeTomaso should have spent, re-arranging the rear suspension a bit to correct flaws in the original design. Back in the car's original era, Sports Car Graphic did a whole number of trying to correct the car, such as fitting more modern Polyglas 60-series tires, finally concluding that it was tail heavy . Their staff was able to improve it, but it was all for naught, the car was only popular as The Car To Own in Tinseltown for a few months, soon eclipsed by the Lamborghini Miura, also mid-engined but with a high winding V12 engine with a real yowl.
SHELBY'S INVOLVEMENT
Carroll Shelby is nothing if not an entrepreneur. Despite the fact that DeTomaso had been so miffed when Shelby pulled funding on the 70P that he had named the subsequent road car the "mongoose" because in nature that is the natural enemy of the Cobra, Shelby was amenable to helping market it in the U.S.
At an auto show, probably the 1969 New York Show, a yellow Mangusta coupe was displayed along with the production Ford cars and the flier handed out to show-goers referred those interested in the car to Carroll Shelby, as if he were the distributor.
At the time, at least two Ford executive were in love with the car including the then VP in charge of design, Eugene Bordinet. Money was even spent in devising a rubber front bumper similar to that later used on the Ferrari 365GTC/4. That nose would have allowed it to meet the upcoming bumper regulations. The Mangustas that did make it into the U.S. were allowed in under a special law that exempted manufacturers who made less than 500 cars from many regulations, but even those regulations wouldn't let it in past 1969.
During their brief love affair with the 'Goose, Ford dispatched two designers to Modena to inspect the Mangustas being built at Ghia Carrozzeria but they came back with a negative report. Their conclusion was that the term "production line" in this case was a misnomer--the cars were really hand-built with variations from car to car. Ford, back in Dearborn, had already tired of that way of doing things in the A.C. Cobras. They pulled away from wanting to import the Mangusta. Fortunately for DeTomaso, Kjell Qvale of British Motor Car Distributors in San Francisco took up the cause and imported at least 180 of the total, selling them for around $11,000 each.
This left Shelby out in the cold. He had been temporarily buoyed by Ford showing a Mangusta in an internal design review that had SHELBY Mk.V badges on it. The badges made sense,for, in 1967 Ford had won the 24 Hours of LeMans for the second time with a Ford GT called the Mk. IV.
But in that same design show there was another Ford prototype, the Mach 2C, a car designed by Ford designer Larry Shinoda that would have been all American-made. It was a svelte design, using a V8 larger than a 302, possibly a 400, and possibly fuel injected. It would have used a Borg-Warner gearbox. But that design became a political casualty when Shinoda's boss, Semon Knudsen, was fired by Henry Ford II.
Ford had hired Bunkie") Knudsen away from GM, where he had spent 29 years , in the hopes he would bring some fresh ideas. But Knudsen had rather too many ideas, even going down to the Styling studio and insisting on changes in the upcoming cars. Henry Ford II summarily fired him after 19 months so all ideas connected to Knudsen were round-filed. When Knudsen left so did his fair-haired boy Shinoda, who Knudsen had brought over from Ford, and who had angered the other designers by reporting only to Knudsen, going around the entire design chain of command. Plus Knudsen had a mortal enemy at Ford—Lee Iacocca—of whom Time magazine quoted some Ford executive as saying: "Lee had chewed his way through ten layers of management to get where he was, and he was determined to chew his way through anyone who was placed above him."
Shelby did eventually come up with his own mid-engined design, the Lone Star, about which we'll do a story on eventually. But it was ignored by Ford and now, some 40 years later, that single car is slowly being restored up in the Northwest where it is in the hands of a well-known Cobra historian.
The Mangusta occupies rather a strange perch. It is one of the great Sixties designs like the Ferrari Daytona and Lamborghini Miura, but where those cars have equally great engines, the mangusta does not. But that just goes to show you that "putting all the money on the outside," an old Detroit slogan, sometimes works. The Mangusta put DeTomaso on the map and led to Ford buying his firm, and Carrozzeria Ghia, at a fat profit to DeTomaso.
He laughed all the way to the bank....
Posted by Half Coct at 2:30 PM
Labels: Carroll Shelby, Cobra, De Tomaso, Detomaso, Ford, Journalism, Mangusta, Shelby, Supercar, Wallace Wyss
D22 Zone March 27, 2011 at 3:51 PM
Excellent post man! Was a really interesting read! thanks for sharing!
CPH March 27, 2011 at 4:07 PM
What a sleek, sophisticated automobile. I have an uncle that will love this blog. Showing him soon, keep up the good work!
Team Panda March 28, 2011 at 2:07 PM
wow nice shelby, ive never seen one like that, only the new ones (which are awesome btw)
Bulwyf March 30, 2011 at 12:01 PM
never saw one these, just awesome.
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Kentucky reports 4 adults have died of the flu this season
Kentucky health officials say four people have died of the flu this season.The four people who have died of influenza since September are all adults, according to Kentucky's Department for Public Health.On Thursday, the city of Louisville reported its first death of the flu season.The victim who died Dec. 7 was an elderly person who had not been vaccinated and had underlying medical conditions, the Louisville Metro Department of Health and Wellness said in a news release.Health officials say the current flu season in Kentucky runs from September to May 2020. Louisville has seen a sharp rise in flu cases in the past two weeks, the Louisville health department said.Through Dec. 7, there had been more than 1,600 flu cases this season in the state, according to the Kentucky health department's weekly influenza report.There have been 124 flu deaths in Louisville since 2015. The Centers for Disease Control and Prevention estimates that influenza has resulted in between 12,000 and 61,000 deaths each year in the United States since 2010, the department said.
LOUISVILLE, Ky. —
Kentucky health officials say four people have died of the flu this season.
The four people who have died of influenza since September are all adults, according to Kentucky's Department for Public Health.
Health officials: 427 new flu cases reported in Metro Louisville
On Thursday, the city of Louisville reported its first death of the flu season.
The victim who died Dec. 7 was an elderly person who had not been vaccinated and had underlying medical conditions, the Louisville Metro Department of Health and Wellness said in a news release.
Health officials say the current flu season in Kentucky runs from September to May 2020. Louisville has seen a sharp rise in flu cases in the past two weeks, the Louisville health department said.
Through Dec. 7, there had been more than 1,600 flu cases this season in the state, according to the Kentucky health department's weekly influenza report.
There have been 124 flu deaths in Louisville since 2015. The Centers for Disease Control and Prevention estimates that influenza has resulted in between 12,000 and 61,000 deaths each year in the United States since 2010, the department said.

redpajama_set_name: RedPajamaCommonCrawl


By Jeff Roux B.P.E; CSCS; TSCC "Life moves pretty fast. If you don't stop and look around once in a while, you could miss it." – Ferris Bueller- Ferris is right, life is fast. It is essential not only to take the time to look around to ensure you don't miss it but also to make the effort required to maximize your health, fitness and performance in order to make sure you can keep up. Luckily, there are now more ways than ever to get moving, get fit, and maximize your opportunity to keep up with the speed of life….


Human Anatomy Laboratory Manual Axial Skeleton - 1 Human Anatomy and Physiology I Laboratory The Axial Skeleton This lab involves study of the laboratory exercise "The Axial Skeleton", completing the. Body Organization and Terminology, Care and Use of the Compound Light Microscope, Cell Structure and Cell Division, Membrane Transport, Epithelial and Connective Tissues, The Integumentary System, The Axial Skeleton, The Appendicular Skeleton, Articulations, Histology of Muscle Tissue, Gross Anatomy of the Muscular System, Physiology of the Muscular System, Histology of Nervous Tissue,. 7 Initial Quiz 1. Define the terms Anatomy and Physiology. 2. List the levels of organization List the levels of organization of the Human Body from least comof the Human Body from least complex to plex to.
Anatomy is a fundamental science that studies the structure of the human body from ancient times. Over time, the discipline constantly expands with recent progress that has been produced in researching the human. Anthropometry (from Greek ἄνθρωπος anthropos, 'human', and μέτρον metron, 'measure') refers to the measurement of the human individual.An early tool of physical anthropology, it has been used for identification, for the purposes of understanding human physical variation, in paleoanthropology and in various attempts to correlate physical with racial and psychological traits.. The Human Body Is Structured By The Skeletal System - The human body is structured by the skeletal system which includes over 200 bones that help protect vital organs..
Learn about the veterinary topic of Imaging Techniques in Equine Lameness. Find specific details on this topic and related topics from the Merck Vet Manual.. Flashcard Machine - create, study and share online flash cards My Flashcards; Flashcard Library; About; Contribute; Search; Help; Sign In; Create Account. Types. A person's prosthesis should be designed and assembled according to the person's appearance and functional needs. For instance, a person may need a transradial prosthesis, but need to choose between an aesthetic functional device, a myoelectric device,.
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Textbook Topic Lab Manual Chapter 7 The Axial Skeleton Exercise 9 ... Transition between axial & appendicular skeleton: the pelvis!


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2019 Dinner Photos
Links & Sponsors
Welcome to the home of Raynes Park Former Pupils' Society (RPFPS).
A Society for pupils who have attended Raynes Park High School both past and present. RPFPS is an independent society with a strong affiliation with the School. It was originally founded in the 1950s by a small group of ex-pupils keen to play rugby, cricket and hockey. Since then the Society has continued to enhance and enrich the traditions of the School. The Society maintains links with the School by sponsoring trophies and awards for outstanding sports boys/girls and has supported many school projects over the years. The latest was a donation of £40,000 towards the new sports ground at Westway Close.
In recent years the number of new members to the Society has dwindled as the original sports sections have become less connected to the School and the Society. The remaining active sporting connection is now the golf section but the annual dinner continues to provide a chance for ex-pupils to catch up with friends old and new. There is a one-off payment for lifetime membership, currently costing less than a round of drinks at £20 for a former pupil. Why not join the Society and become part of the School's rich history? The Society wouldn't be anywhere without its former pupils and without new members joining, the Society will inevitably decline. So please take 5 minutes to have a look at the website and see what benefits the Society has to offer and do your part to keep the long standing traditions of the Society alive by becoming a member today.
To apply for membership, CLICK HERE to download the application form.
© 2017 Raynes Park Former Pupils' Society.
Raynes Park Former Pupils' Society Privacy Policy.


Phi Phi Hotel on Phi Phi Island was our choice for the family Christmas break. With 4 families including grand parents, 4 kids and 2 infants was a big enough group and phi-phi.com sorted out our booking with no problem.
Phi Phi Hotel is a 4 storey hotel building right next to the main pier in Tonsai Village. It was a simple walk from the Sea Tran ferry from Phuket and the porters carried our bags ( and kids ) on the trolley carts. Checking in was straight forward with a signature, home address and passport number and we soon had our hotel room keys and direction to our rooms (Not everybody had a porter to their room).
The Mountain View Room had views of the coconut trees, Phi Phi Village bazaar and one room had a glimpse of the back bay (Loh Dalum Bay). The Sea View Rooms had amazing views of Tonsai Bay cliffs, the coral reefs, the pier and the Bay. The Grandparents had the VVIP room on the 4 th floor and although they didn't enjoy the walk up the stairs every time (no lift) their room had an extended balcony with a lot of room.
The kids settled in quickly, getting to grips with the cartoon network on the TV and generally making a mess so we spent as little time there as possible and spent most of the time on the Beaches, at the pool or taking tours with Siam UK.
With about 70 rooms it is small enough so that you can remember faces of the staff and other guests. Phi Phi Hotel had all the main facilities required. Breakfast was good enough for the kids. The Hotel seemed very busy but as it is so centrally located for everything it made it simple to get around with such a large group. Service was polite if lacking a little with eagerness. The staff were genuinely helpful with the infants and kept them happy while we ate at the Pakarang restaurant. A good stay.


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Q: how can a process execute network code I am a beginner to networking and I have a few questions regarding networking.
1)How can a process execute code that is sent from a different computer on the network. Generally a process's code segment cannot be changed once its loaded to ensure protection. (Also I can execute some arbitrary code to corrupt the process's memory)
2)Also can a process hear to multiple ports ? And multiple processes can hear to a same port ? For example two https associated with port 80. How to distinguish between the processes and how to ensure protection ?
3)Also I would like to know how listen is implemented in sockets. Are they implemented as software interrupts ?
Any good book recommendations are very much appreciated.
Thanks & Regards,
Mousey.

A: Q: How can a process execute code sent from another machine?
A: Generally, this is a bad idea as the security concerns are difficult to fully explore.  However, this can be done by saving the network-delivered code to a separate executable and then launching this new program.  This can also be done on most systems by just treating the raw bytes received as code; load the bytes into the heap (not the stack!), cast the address to a function pointer, and call it.  Again though, this is almost certainly a bad idea.
Q: Can a process listen on multiple ports simultaneously?
A: Yes.  By the way, HTTPS is port 443.  HTTP is port 80.
Q: Can multiple processes listen on the same port (with the same protocol, on the same address)?
A: No.  Other processes might be able to eavesdrop and also receive the packets, but they're not directly bound to the port.  In general, only one process can be bound to a given protocol/port/address 3-tuple.
Q: How is blocking while listening on a socket implemented?
A: By the operating system, in its own fashion.  Generally a thread is moved into the "blocking" state when it calls accept, read, or poll/select on a non-ready socket, and will not receive CPU time until some data have arrived.

A:
1)How can a process execute code that is sent from a different computer on the network. Generally a process's code segment cannot be changed once its loaded to ensure protection.

This has nothing to do with networking. Once you receive the data through a socket, it's in your local memory. What you do after that is OS-specific. For example, on Windows, you can use VirtualProtect to mark pages as executable.

2)Also can a process hear to multiple ports ?

Sure, just create a different socket for each port you want to listen to. Of course, to use them simultaneously, you either need to use non-blocking sockets or run each socket in a separate thread.

3)Also I would like to know how listen is implemented in sockets. Are they implemented as software interrupts ?

This is entirely OS-specific. listen just sets up the socket so that it can accept connections. Any connection requests that arrive after this (this probably happens somewhere in the TCP/IP driver) are put in a queue by the OS. When you later call accept, the OS pulls out the first pending connection from this queue and returns a socket to that.

redpajama_set_name: RedPajamaStackExchange


I know firsthand the benefits that exercise in general, and weight training in particular, can bring. Not only did weight lifting help me combat scoliosis, but it gave me the strength and energy to live an active life of sport, travel, and family. In addition, to physical strength, it helped me develop the mental strength and discipline to become a top Phi Beta Kappa student and an Ivy League educated lawyer. My doctor tells me that weight training has also given me good cholesterol levels, helped me keep off those extra pounds that usually comes as someone gets older, and slowed many of the normal signs of aging.
Anyone who has heard the television news or picked up a newspaper or looked on the Internet lately knows that there is an epidemic of child obesity. According to the National Institute of Health, almost 36% of adults in America are obese. Incredibly, three quarters of American men are overweight or obese. Obesity-related health conditions include heart disease, stroke, type 2 diabetes and certain types of cancer, some of the leading causes of preventable death. Even worse, overweight and obese children are more likely to become overweight or obese adults. As a country, we are heading towards a crises of having millions of people who are not only an expensive burden on the healthcare system, but who will be not enjoy a quality of life. This can be prevented if more people exercised.


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package com.rocana.lucene.codec.v1;

import org.apache.lucene.codecs.PostingsFormat;
import org.apache.lucene.codecs.simpletext.SimpleTextPostingsFormat;
import org.junit.Assert;
import org.junit.Test;

/**
 * Unit test for {@link RocanaPerFieldPostingsFormat}.
 *
 * This test class contains additional Rocana tests and is not a fork of
 * any existing Lucene tests. In other words, these tests are original.
 */
public class TestRocanaPerFieldPostingsFormat3 {

  /**
   * This is a sunny day test, ensuring the method returns the postings format it
   * was asked to return. This does not cover any special cases, like "Lucene50".
   */
  @Test
  public void lookupPostingsFormatShouldReturnTheRocanaPostingsFormat() {
    String shortName = RocanaLucene50PostingsFormat.SHORT_NAME;
    PostingsFormat expected = PostingsFormat.forName(shortName);

    PostingsFormat actual = RocanaPerFieldPostingsFormat.FieldsReader.lookupPostingsFormat(shortName);

    Assert.assertSame("Expected the same instance the SPI lookup returns", expected, actual);
    Assert.assertEquals("Expected an instance of the class we asked for",
      RocanaLucene50PostingsFormat.class, actual.getClass()
    );
  }

  /**
   * This verifies we have logic to return Rocana's custom postings format
   * whenever asked for Lucene's postings format.
   *
   * This scenario comes up as Lucene reads old index files (from data written
   * with the original Lucene54 codec, before Rocana's custom codec). When
   * Lucene reads those index files and comes across "Lucene50" specified as the
   * postings format, the code we're testing asks the SPI (Service Provider Interface)
   * for that "Lucene50" postings format, but we want it to use our custom postings
   * format for the performance benefits. So instead we return Rocana's fork of
   * the postings format. This only works because the on-disk representation of
   * both Lucene's and Rocana's postings formats are identical.
   */
  @Test
  public void lookupPostingsFormatShouldReturnTheRocanaPostingsFormtForLucene50() {
    PostingsFormat rocanaPostingsFormat = PostingsFormat.forName(RocanaLucene50PostingsFormat.SHORT_NAME);

    PostingsFormat actual = RocanaPerFieldPostingsFormat.FieldsReader.lookupPostingsFormat("Lucene50");

    Assert.assertSame("Expected the same instance the SPI lookup returns", rocanaPostingsFormat, actual);
    Assert.assertEquals("Expected an instance of the class we asked for",
      RocanaLucene50PostingsFormat.class, actual.getClass()
    );
  }

  /**
   * This is a sunny day test to ensure the method returns the postings format
   * asked for. The other tests verify how the method behaves when returning
   * {@link RocanaLucene50PostingsFormat}, which means if the method
   * always 100% of the time returned {@link RocanaLucene50PostingsFormat} those
   * tests would pass. This test ensures the method actually does return the
   * real postings format asked for, and therefore proves the method only does
   * something special when asked for "Lucene50".
   */
  @Test
  public void lookupPostingsFormatShouldReturnThePostingsFormatAskedFor() {
    String shortName = "SimpleText";
    PostingsFormat expected = PostingsFormat.forName(shortName);

    PostingsFormat actual = RocanaPerFieldPostingsFormat.FieldsReader.lookupPostingsFormat(shortName);

    Assert.assertSame("Expected the same instance the SPI lookup returns", expected, actual);
    Assert.assertEquals("Expected an instance of the class we asked for",
      SimpleTextPostingsFormat.class, actual.getClass()
    );
  }

}

redpajama_set_name: RedPajamaGithub


Q-symbio is a randomized, placebo-controlled, double-blinded study, begun in 2003 under the direction of Associate Professor Svend Aage Mortensen (picture) from the Copenhagen University Hospital. The study involved 420 patients with severe heart failure (NYHA* Class III or IV) from nine different countries. The participants were randomly chosen to receive either soft gelatin capsules with Q10 as ubiquinone each day or identical-looking placebo capsules. The participants in the two groups were then followed for 2 years.
The aim of the study was to investigate how much time would elapse until the participants in the two groups again encountered heart problems, meaning unplanned hospitalizations because of heart failure, fatal heart attacks, a need for cardiac transplantation, or a need for a mechanical assist pump (a heart pump).
If you calculate the study's patient-years, the Q-symbio clinical trial is actually the largest placebo-controlled study of coenzyme Q10 for heart failure in the world to date. The study and its groundbreaking results have also aroused great interest and curiosity among medical doctors and scientists in many countries and especially in the U.S., where Svend Aage Mortensen has given several presentations on the results. More interest in coenzyme Q10 will be generated by the publication of the study results..
* The NYHA classification is an official ranking system used globally that divides heart failure patients into four individual categories depending on the severity of their symptoms.
The study showed that patients in the Q10 group had a 43% decrease in cardiovascular death compared to the placebo group. Only 15% of the patients in the Q10 group experienced serious heart events, called MACE events, compared with 26% of the patients who received the placebo, corresponding to a 43% relative reduction, which was a statistically significant result. Supplementation with Q10 also significantly reduced the risk of death from all causes by 42% compared to the placebo group. The number of unplanned hospitalizations was 8% in the Q10 group against 14% in the placebo group, which was also a statistically significant difference. Moreover, there were significantly more of the Q10-treated patients who improved one or more NYHA class than in the group receiving placebo (58% versus 45%). One patient in the Q10 group went from NYHA IV to NYHA I during his treatment. In addition, a biological marker for heart disease called NT-proBNP was slightly improved in the Q10 group, and the Q10 group also experienced fewer side effects.
Chief Physician Dr. Steen Stender, Clinical Biochemistry Department, Gentofte Hospital, Quoted in Jyllandsposten. 2014, Oct.19, in response to the Q-symbio study.
"CoQ10 is the first new medication to improve survival in chronic heart failure, and it should be added to standard therapy."
Assoc. Prof. Dr. Svend Aage Mortensen, Head of the Q-Symbio study.
At a Q10 conference at Columbia University in New York 2018, Dr. Svend Aage Mortensen's daughter, biochemist Anne Louise Mortensen, presented new data from the European subgroup of the patients in the Q-Symbio study. This new analysis included 231 patients from Denmark, Sweden, Austria, Slovakia, Poland and Hungary. The Q10 group comprised 108 patients who received (Myoqinon) 100 mg Q10 x 3 daily. The placebo group with similar characteristics represented 123 patients.
Why were there significantly better results in the European subgroup?
There may have been better compliance (patients have been better taking their medication)?
Egwim C, et al. Global variations in Patient populations and Outcomes in Heart Failure Clinical Trials. Curr. Heart Fail. Rep. 14, 30-39 (2017).
Mortensen SA, et al. The effect of coenzyme Q10 on morbidity and mortality in chronic heart failure: results from Q-SYMBIO: a randomized double-blind trial. JACC. Heart Fail. 2,641-9 (2014).


By promoting awareness of the early signs of autism.
For example, by hosting a workshop for local parents or professionals or by inviting us to contribute an article to a newsletter.
For example, by using our expertise in the design or review of services.
By helping us to raise funds for treatment.
For example, by running a fundraising event or by making a donation. Go to our JustGiving page to make a donation, to start a campaign or to donate funds to an existing campaign.
We are interested in your ideas of how we can work together. Go to our Contact us page to let us know what you think.


text:
You Are the Music...We're Just the Band is the third studio album by British rock band Trapeze. Recorded with producer Neil Slaven, it was released in 16 March 1972 by Threshold Records. The album was preceded by the release of the single "Coast to Coast" in 1972.

Background
You Are the Music...We're Just the Band was the last Trapeze album recorded by the lineup of Glenn Hughes, Mel Galley and Dave Holland, as Hughes left the band in 1973 to join Deep Purple. The album was also the band's first not to be produced by John Lodge, and featured a wide range of guest performers, including guitarist B. J. Cole, pianist Rod Argent and saxophonist Jimmy Hastings. Five of the album's eight songs were written by Hughes, while the other three were written by Galley and his brother Tom.

Reception

Critical reception for You Are the Music...We're Just the Band was generally positive. Variety called the album "another hard-rockin' set by Trapeze".

Legacy
A retrospective review for AllMusic, Richard Foss praises Hughes's vocal performances and the "softer tunes" of the album. Foss named "Coast to Coast" and "What Is a Woman's Role" as particular highlights.

Track listing

Personnel

Primary personnel
Glenn Hughes – bass, piano, vocals
Mel Galley – guitar
Dave Holland – drums, percussion
Technical
Neil Slaven – production
John Burns – engineering
Dave Grinsted – engineering
Carl Dunn – photography
Fin Costello – photography
Garry Sharpe-Young – liner notes

Guest musicians
B. J. Cole – steel guitar on "Keepin' Time" and "Coast to Coast"
Rod Argent – electric piano on "Coast to Coast", piano on "Feelin' So Much Better Now"
Kirk Duncan – electric piano on "What Is a Woman's Role"
John Ogden – percussion on "What Is a Woman's Role"
Frank Ricotti – vibraphone on "Will Our Love End"
Jimmy Hastings – alto saxophone on "Will Our Love End"

References

1972 albums
Funk rock albums
Trapeze (band) albums
Threshold Records albums

redpajama_set_name: RedPajamaWikipedia


Our business started in 1996 doing residential roofing and siding before adding Minneapolis exterior design and build capabilities for remodeling projects and building artisan homes. We are exterior systems integrators who promise to install exterior cladding and roofing to meet or exceed manufacturer recommendations for all exterior renovation projects. For homeowners involved in construction defect litigation, we have experience providing in-court testimony and writing cost estimates. Because AMEK Exteriors has construction defect expertise and in-depth knowledge of construction techniques and building codes, we can reassure homeowners that we can not only diagnose damage caused by improper building techniques but also know how to repair it to prevent future issues.
What does condensation or fogging mean on my windows?


We want you to be completely satisfied with your purchase. If for any reason you are not happy, simply return the product in as new condition with a copy of your invoice and we will offer you a replacement, exchange or full refund for purchase price minus shipping fees. If the return resulted due to error on our part, shipping fees will be refunded as well.
Refund issued within 7 business days of our receiving your return.


When King Khan (then 'Blacksnake') decided to stay in the land of kraut and honey, they always maintained that they would soon lay waste to this miserable world. And so they began in 2002. BBQ visiting my man King Khan, and jamming in his Nazi-bunker rehearsal space. They took it easy, honing their craft, playing sporadically around Germany and Spain to crowds outraged by their incredible sound and nasty live show. Two guys. One smashing snare, bass drum and tambourine with his bare feet, molesting his guitar and singing like a possessed angel. The other spinning and howling like a freak while belting it out on his guitar like a real gone savage.


The UNL Web Developer Network is an open-invitation group of web developers working together to build UNL's websites.
The WDN operates by consensus, and a comprehensive list of standards (the Standards Guide) has been created to achieve a consistent experience for users of UNL websites. The Standards Guide is the guiding document for the WDN Quality Assurance process. The overall direction of the WDN is led by an elected Governance Board.
These resources are available to all interested parties, and your participation is welcome. Meetings are held on Second Tuesdays at 2 p.m. in the Nebraska Union. If you need immediate assistance, try the WDN chat room.
The first question we get is: "Why?"
You may not know it, but Nebraska is unique online.
Since 2007, UNL has had a unique set of standards for the development of the website that represents our university. All sites are published using a single template and codebase that we call the UNLedu Web Framework. This organization, the UNL Web Developer Network, was formed to encourage engagement and participation in that effort. To our knowledge, we're still the only R1 university taking this approach. Which naturally leads to a question: Are we nuts? Perhaps. But perhaps not.
DID YOU KNOW that UNLedu WAS RECOGNIZED by eduStyle as the 'BEST OVERALL WEBSITE' of 2014?
You may be interested to know why this university has chosen this unique — for a university — path.
OUR BRAND IS IMPORTANT TO US While the term turns some off, especially in academia, brands are important. As a large public entity, our brand is our identity; it's our name and our face to the world. Well-managed brands benefit through each impression. In our case, UNL's identity — its brand — is enhanced each time a story about us comes out, whether it's told around the dinner table about a new Nebraska grad, or in the New York Times about an important new discovery enabled by our research. In our publications and websites, it's important that our brand is consistently and attractively displayed. The UNLedu Web Framework accomplishes that.
OUR COMMUNITY IS OUR STRENGTH The web is being reinvented every day. Over time, those little changes sometimes add up to big things, like responsive design, which is the ability to serve up pages that adapt to any screen size. Or CSS Grid, which creates an entirely new foundation for the future of web development, and which the Framework 5 release (2019) incorporates. In either case, no longer do sites need to maintain a completely separate website targeted to mobile devices. Instead, the site itself adapts to the parameters of whatever device it's displayed on. By continually reinventing the UNLedu Web Framework, we can incorporate new technologies, consistently throughout the website, at a level of efficiency that would just not be possible by taking any other approach. When responsive design was first introduced in the UNLedu Web Framework in 2012, this web community pressed forward together and quickly made the entire website, all 500,000 pages of it, optimized for any device, from 'classic' desktops and laptops, to tablets, to smartphones and more. The introduction of Grid in 2019 creates amazing new design and presentation possibilities as we continue to move forward.
OUR FUTURE IS BUILDING Just like the web in general aggregates bunches of little things into Next Big Things, the continual development of the UNLedu Web Framework continues to yield interesting results in delivering computing services directly, and transparently, to our users. Building an ecosystem in which we could maintain and update our codebase across multiple websites and web applications required some innovative thinking in code distribution. Today, synchronization of our framework code is a mature and every-day process. To that sync process, it doesn't matter whether that code is related to look and feel issues or if it's related to adding new functions. And some functions just make the most sense when delivered at the highest possible scale; when they're available from any page.
Today, each and every page of the UNL website offers a place to log in, and each and every page, when the user is logged in, carries a 'ticket' when logged in that allows the user to go from one service to the next without continually entering usernames and passwords (not all authenticated services at UNL take advantage of this single sign-on system, yet). Every page continually monitors for emergency alerts, and immediately displays any that are issued. Every page includes a comprehensive constituent-chat system that, when used well, brings us into direct contact with site visitors, giving them a personal touch of Nebraska hospitality. Every page is built from foundations that incorporate high standards of accessibility and code validity, giving developers a head start on supporting diversity and inclusion in the digital space, providing good search engine optimization, and delivering compatibility with the widest-possible variety of web browsers.
In the future, users could even – from any page – access a notification center that would aggregate the latest notifications from all major systems in one single drop-down panel (think Facebook notifications but, like, important).
It's things like this that make working on the UNL Web Framework interesting and exciting. Already, it's much more than a set of design instructions. Today it's an aggregation of best ideas for design and computing from across the university. As it continues to evolve, along with the web, its relevance and its ability to serve our users is only limited by our collective imaginations. Yours is welcome here.


On 3/25 we will spend some time reviewing rank size rule and primate cities. It would be in your best interest to research them before hand to insure that you really understand these ideas.
Christaller's Central Place Theory has serious theoretical and practical applications for the distribution of goods and services in a region/country.
C) What are two disadvantages for a region and/or country having a primate city?
Discuss two specific strategies that a region and/or country have used to slow down the growth of their primate city.


Here we have another image Cocinas Rusticas Modernas Con Chimenea Cocinas Fotos Modernas Unique Cocinas Rusticas Con Chimenea Diseno featured under Cocinas Rusticas Modernas Con Chimenea Cocina Rºstica Con Muebles De Madera De Roble Machihembrado — Fiesta. We hope you enjoyed it and if you want to download the pictures in high quality, simply right click the image and choose "Save As". Thanks for reading Cocinas Rusticas Modernas Con Chimenea Cocina Rºstica Con Muebles De Madera De Roble Machihembrado — Fiesta.


Is the wall space in your area dull? When they really are, you have to think about making a brand new appealing style. It could be an inconvenience to beautify an area but dull wall space is not appealing.
In luck, you will discover a few ideas that will simplify your room decoration. One of the tips is by using bedroom wall decals. Because wall decals are not long lasting, you could redesign the room whenever you need.
We have just used for a couple of days but this is what I could show you to date: I study a lot of testimonials about this kind of item before creating my choice to purchase the dot decals verses the stars. These are definitely more cash but from things I could show to date, they never not dropped off since yet (there is an approximate roof), they were simple to set up.
The shine is excellent, we laid the coverings in our kitchen area together with all of the lighting on before using to kids' room ceilings. They will steadily dim which means that the children can turn to sleep. I set the dots up to be able to create the constellations so that they can be an excellent education instrument. Click here for more details.
It is beautiful! Really worth the cost. The stickers on their own are very durable. Almost every other quote decal I have purchased (from some other retailers) is extremely thin and low-cost looking. The lettering is an extremely great sizing. The single problem I had placing this up is the small scroll arrangements. They were a bit difficult to move.
They actually threw in a compact dimensions "Always Kiss Me Good Night" sticker. Appears excellent within my bedroom. This will take persistence to ensure it is flat. For the gray in background truly not gray. There is certainly a few shadowing but hey to every his own since mine is not visible except if you looking at it for over five minutes flat. Click here for more details.
There is textured wall space and decided to try at any rate. Nicely, it doesn't attach properly to textured wall space. It appeared good on the wall structure but will gradually peel off on its own. Therefore, because I am not an expert painter, I traced it to the wall surface and then hand coated it. I then taken off the decal so it appears beautiful within my son's room. Therefore, managed to get double use of it.
This tree is wonderful. It is complicated to find the correct parts but I was capable to modify a few branches to suit my area. I actually do need extra branches as well as frames however I have matched the coloring to incorporate branches.
Actually, this bedroom wall decals helps make my wall appear great with images in every one of the squares. It started to take me a couple of hours to accomplish it, every branch, leaf and squares come in different parts but they are labeled with a good simple diagram to carry out if you wish. Click here for more details.


Happiest of Fridays, friends! Today's swap card was made by Rachel Dechant. The stamp set (Still Night) and coordinating thinlits dies can be found on page 41 of the Holiday Catalog.
I love the 3/8″ Black Glittered Organdy Ribbon!


Artificial sweeteners help individuals with obesity to cut calories and lose weight but may have negative health effects, according to researchers at York University's Faculty of Health.
"Our study shows that individuals with obesity who consume artificial sweeteners, particularly aspartame, may have worse glucose management than those who don't take sugar substitutes," says Professor Jennifer Kuk, obesity researcher in the School of Kinesiology and Health Science.
Normally, weight loss is associated with several improvements in health. Artificial sweeteners are often used to help individuals cut calories and manage their weight as they are not digested by the body. However, the recent study suggests that the bacteria in the gut may be able to break down artificial sweeteners, resulting in negative health effects.
"We didn't find this adverse effect in those consuming saccharin or natural sugars," says Kuk. "We will need to do future studies to determine whether any potentially negative health effects of artificial sweeteners outweigh the benefits for obesity reduction."
Currently, there are many new sugar substitutes that are used in foods. The researchers note that further investigation is needed to determine if there are any health effects of using these sweeteners.
For the study, data from 2856 U.S. adults from the Third National Health and Nutrition Survey (NHANES III) was used. Individuals reported their diet over the past 24 hours and were categorized as consumers of artificial sweeteners (aspartame or saccharin), or high or low consumers of natural sugars (sugar or fructose). Diabetes risk was measured as the ability to manage blood sugars using an oral glucose tolerance test.


text:
/*
 * buildingBlock.cpp
 *
 *  Created on: 22 mars 2013
 *      Author: dom
 */

#include <iostream>

#include "buildingBlock.h"
#include "world.h"
#include "simulator.h"
#include "scheduler.h"
#include "trace.h"

using namespace std;

namespace BaseSimulator {

bID BuildingBlock::nextId = 0;
bool BuildingBlock::userConfigHasBeenParsed = false;

//===========================================================================================================
//
//          BuildingBlock  (class)
//
//===========================================================================================================

  BuildingBlock::BuildingBlock(int bId, BlockCodeBuilder bcb, int nbInterfaces) {
    OUTPUT << "BuildingBlock constructor (id:" << nextId << ")" << endl;

    if (bId < 0) {
      blockId = nextId;
      nextId++;
    } else {
      blockId = bId;
    }

    state.store(ALIVE);
    clock = new PerfectClock();

    ruint seed = Simulator::getSimulator()->getRandomUint();
    seed *= bId;
    generator = uintRNG(seed);

    buildNewBlockCode = bcb;

    if (utils::StatsIndividual::enable) {
      stats = new StatsIndividual();
    }

    for (int i = 0; i < nbInterfaces; i++) {
        P2PNetworkInterfaces.push_back(new P2PNetworkInterface(this));
    }

    wirelessNetworkInterface = new WirelessNetworkInterface(this,4.5,-82,-110);
    //setDefaultHardwareParameters();

    blockCode = (BaseSimulator::BlockCode*)bcb(this);

    // Parse user configuration from configuration file, only performed once
    if (!userConfigHasBeenParsed) {
      userConfigHasBeenParsed = true;
      blockCode->parseUserElements(Simulator::getSimulator()->getConfigDocument());
    }

    isMaster = false;
}

BuildingBlock::~BuildingBlock() {
    delete blockCode;
	OUTPUT << "BuildingBlock destructor" << endl;

	if (clock != NULL) {
		delete clock;
	}

	if (stats != NULL) {
	        delete stats;
	}

	for (P2PNetworkInterface *p2p : P2PNetworkInterfaces)
		delete p2p;
}

bool BuildingBlock::addP2PNetworkInterfaceAndConnectTo(BuildingBlock *destBlock) {
    P2PNetworkInterface *ni1, *ni2;
    ni1 = NULL;
    ni2 = NULL;
    if (!getP2PNetworkInterfaceByBlockRef(destBlock)) {
		// creation of the new network interface
		OUTPUT << "adding a new interface to block " << destBlock->blockId << endl;
		ni1 = new P2PNetworkInterface(this);
		P2PNetworkInterfaces.push_back(ni1);
    }

    if (!destBlock->getP2PNetworkInterfaceByBlockRef(this)) {
		// creation of the new network interface
		OUTPUT << "adding a new interface to block " << this->blockId << endl;
		ni2 = new P2PNetworkInterface(destBlock);
		destBlock->P2PNetworkInterfaces.push_back(ni2);
    }

    if (ni1!=NULL && ni2!=NULL) {
		ni1->connect(ni2);
		return (true);
    } else {
		OUTPUT << "*** ERROR *** could not connect the new interfaces" << endl;
    }
    return false;
}

bool BuildingBlock::addP2PNetworkInterfaceAndConnectTo(int destBlockId) {
    // if the link is not in the list
    BuildingBlock *destBlock = BaseSimulator::getWorld()->getBlockById(destBlockId);
    if (!getP2PNetworkInterfaceByBlockRef(destBlock)) {
		// creation of the new network interface
		P2PNetworkInterface* ni1 = new P2PNetworkInterface(this);
		P2PNetworkInterfaces.push_back(ni1);
		// if the corresponding interface exists in the connected block, we link the two interfaces
		if (destBlock->addP2PNetworkInterfaceAndConnectTo(this)) {
			P2PNetworkInterface* ni2 = destBlock->getP2PNetworkInterfaceByBlockRef(this);
			ni1->connect(ni2);
		}
    }
    return false;
}

P2PNetworkInterface *BuildingBlock::getP2PNetworkInterfaceByBlockRef(BuildingBlock *destBlock) {
    for(P2PNetworkInterface *p2p : P2PNetworkInterfaces) {
		if (p2p->connectedInterface) {
			if (p2p->connectedInterface->hostBlock == destBlock) {
				return p2p;
			}
		}
    }
    return NULL;
}

P2PNetworkInterface*BuildingBlock::getP2PNetworkInterfaceByDestBlockId(bID destBlockId) {
    for(P2PNetworkInterface *p2p : P2PNetworkInterfaces) {
		if (p2p->connectedInterface) {
			if (p2p->connectedInterface->hostBlock->blockId == destBlockId) {
				return p2p;
			}
		}
    }
    return NULL;
}

unsigned short BuildingBlock::getNbNeighbors() {
  unsigned short n = 0;
  P2PNetworkInterface *p;
  vector<P2PNetworkInterface*>::iterator it;
  for (it = P2PNetworkInterfaces.begin(); it != P2PNetworkInterfaces.end(); ++it) {
    p = *it;
    if (p->isConnected()) {
      n++;
    }
  }
  return n;
}

void BuildingBlock::scheduleLocalEvent(EventPtr pev) {
    localEventsList.push_back(pev);

    if (localEventsList.size() == 1) {
		Time date;
		date = max(pev->date,this->blockCode->availabilityDate); // WARNING: is blockCode->availabilityDate considered?
		if (date < getScheduler()->now()) date=getScheduler()->now();
		getScheduler()->schedule(new ProcessLocalEvent(date,this));
    }
    return;
}

void BuildingBlock::processLocalEvent() {
    EventPtr pev;

    if (localEventsList.size() == 0) {
		cerr << "*** ERROR *** The local event list should not be empty !!" << endl;
		getScheduler()->trace("*** ERROR *** The local event list should not be empty !!");
		exit(EXIT_FAILURE);
    }
    pev = localEventsList.front();
    localEventsList.pop_front();
    blockCode->processLocalEvent(pev);

    if (pev->eventType == EVENT_NI_RECEIVE ) {
      utils::StatsIndividual::decIncommingMessageQueueSize(stats);
    }

    if (blockCode->availabilityDate < getScheduler()->now()) blockCode->availabilityDate = getScheduler()->now();
    if (localEventsList.size() > 0) {
		getScheduler()->schedule(new ProcessLocalEvent(blockCode->availabilityDate,this));
    }
}

void BuildingBlock::setColor(int idColor) {
    const GLfloat *col = tabColors[idColor%12];
    color.set(col[0],col[1],col[2],col[3]);
    getWorld()->updateGlData(this);
}

void BuildingBlock::setColor(const Color &c) {
    if (state.load() >= ALIVE) {
		color = c;
    }
    getWorld()->updateGlData(this);
}

void BuildingBlock::setPosition(const Cell3DPosition &p) {
    position = p;
    getWorld()->updateGlData(this);
}

void BuildingBlock::tap(Time date, int face) {
    OUTPUT << "tap scheduled" << endl;
    getScheduler()->schedule(new TapEvent(date, this, (uint8_t)face));
}

ruint BuildingBlock::getRandomUint() {
    return generator();
}

void BuildingBlock::setClock(Clock *c) {
  if (clock != NULL) {
    delete clock;
  }
  clock = c;
}

Time BuildingBlock::getLocalTime(Time simTime) {
  if (clock == NULL) {
    cerr << "device has no internal clock" << endl;
    return 0;
  }
  return clock->getTime(simTime);
}

Time BuildingBlock::getLocalTime() {
    if (clock == NULL) {
      cerr << "device has no internal clock" << endl;
      return 0;
    }
    return clock->getTime();
}

Time BuildingBlock::getSimulationTime(Time localTime) {
    if (clock == NULL) {
      cerr << "device has no internal clock" << endl;
      return localTime;
    }
    return clock->getSimulationTime(localTime);
}

/*************************************************
 *            MeldInterpreter Functions
 *************************************************/

unsigned short BuildingBlock::getNeighborIDForFace(int faceNum) {
    short nodeID = P2PNetworkInterfaces[faceNum]->getConnectedBlockId();

	return nodeID > 0  ? (unsigned short)nodeID : 0;
}

int BuildingBlock::getFaceForNeighborID(int nId) {
	for (uint face = 0; face < P2PNetworkInterfaces.size(); face++) {
		if (nId == getNeighborIDForFace(face))
			return face;
	}

	return -1;
}

} // BaseSimulator namespace


text:
Q: Two different syntax structure for Selenium I'm using using AutoHotkey to drive SeleniumBasic v2.0.9.0
I'm new to Selenium and have been looking at a lot of different pages discussing how to get/set elements on a webpage.  I've noticed there seems to be (at least )two different types of format for syntax.
Here are two examples:
 1. driver.findElementByID("search_form_input_homepage").SendKeys("hello")
 2. driver.findElement(By.id("search_form_input_homepage")).SendKeys("hello")

In my case the first one works but the second throws an error saying No such interface supported. I'm just curious of the origin of the second structure.  Is it from Selenium 3?

A: Here is the Answer to your Question:

*

*driver.findElementByID("search_form_input_homepage").SendKeys("hello") : Is in use through the VBA module maintained by @FlorentB.

*driver.findElement(By.id("search_form_input_homepage")).SendKeys("hello") : Is in use through the Java bindings of Selenium.

Let me know if this Answers your Question.


text:
Richest stars Born today Born tomorrow Born in February Popular stars
: 22 June 1921
: 31 October 1991
: 70 years
Ask / say what you think about JOSEPH PAPP:
Joseph Papp Wiki
Joseph "Joe" Papp was an American theatrical producer and director
Born: 22 June 1921 Comment
When did Joseph Papp die? / Died 31 October 1991
How many years did Joseph Papp live? / Lived 70 years
Joseph Papp Net worth 2023 (estimated)
How much is Joseph Papp worth? Under review
Joseph Papp facts
Papp established The Public Theater in what had been the Astor Library Building in downtown New York
"The Public," as it is known, has many small theaters within it
There, Papp created a year-round producing home to focus on new creations, both plays and musicals
Among numerous examples of these creations were the works of David Rabe, Ntozake Shange's For Colored Girls Who Have Considered Suicide When the Rainbow Is Enuf, Charles Gordone's No Place to Be Somebody (the first off-Broadway play to win the Pulitzer Prize), and Papp's production of Michael Bennett's Pulitzer Prize–winning musical, A Chorus Line
Upon Papp's death, The Public Theater was renamed the Joseph Papp Public Theater
Photo credit: https://www.wikipedia.org/
Cancer celebrities Born June 22 Born in February Richest stars


The Marine Conservation Society are calling out for volunteers to roll up their sleeves to help clean Gunwalloe Fishing Cove and Church Cove as part of the annual Great British Beach Clean.
This year many of the plastics removed from clean-up events will be sorted and recycled, giving them a second life as new products. Rigid plastic and cigarette stubs will be turned into shampoo bottles and advertising boards.
To join in the beach cleans at Fishing Cove on Saturday from 9am, or at Church Cove on Sunday from 2pm, register as a volunteer at mcsuk.org.
Toby Hines founded the Helston Advertiser in 2000 and is a passionate supporter of local businesses. He is a big believer in health and wellness and likes to begin most days with a walk around Helston with his Golden Retriever or an hour in the gym. A father of three, he is happiest when spending quality time with the family.
Should time be called on pub music?
Our future plans – we want your views!
Mullion Food Bank, every Friday from 10.00am to 12.00pm, at Mullion Methodist Chapel, Mullion (opposite Boots).
Copyright © 2019 Helston Advertiser. All rights reserved.


Happy New Year: Farewell & Many Thanks 2011!
A New Beginning lurks around the corner. Unwrap it with a joyful spirit! Farewell to 2011- to all your happy memories, the tough moments, and the love. This year past was a gift. One I will be eternally grateful for.
Are You a Booze Bag?
It's a valid question, especially at this time of year. I'm not evaluating myself until I'm sober. Maybe January second I will take a look at what I am doing where wine is concerned. Meg and I have been tossing around not drinking at all in January. I'm already afraid. That's a lot days.
What are your plans for New Year's Eve? Wherever you go to celebrate the coming of the new year, make sure you do it in style! Essie New Year's Eve Metallic Color Collection is exactly what you need to finalize your fun, fabulous party ensemble.
"I don't have time." "I don't have money." "I'm just too busy." These excuses (that we all make at some point or another) are no longer valid. We've all been guilty of staying within our comfort zone, even if we aren't truly comfortable there. We spend time dreaming of better scenarios but then make excuses about why we can't change.
Kings of Leon Caleb Followill and Model Lily Aldridge are Expecting a Baby!
Today, I Won't Take You For Granted!
Last night, as I laid my head down for bed a thought came over me – often I take my kids for granted. That keeps me from fully appreciating the miracle that they are. It was a long and exhausting bedtime routine, as they sometimes are. I was looking forward too much to them being asleep instead of enjoying the moment fully with them.
Our new baby gives me time for reflecting and its a perfect time of year to do so.
The day after Christmas, I was reading my daughter a bedtime story. It was Zen Shorts by Jon J. Muth, a book about three siblings who each learn a Zen principle in an encounter with a giant panda named Stillwater.
Are you ready for a whale of a tale? A Dolphin Tale, that is. Dolphin Tale is a heart-warming story about a poor little dolphin who gets caught in crab trap and seriously hurts her tail.


Research demonstrates that children who attend reliable, high-quality, licensed early care programs that adequately address their early development needs are better prepared for school, have better educational outcomes, and require less social service interventions. As adults, they earn more income, have higher rates of home ownership, and pay more taxes than children who do not participate in such programs. However, access to high quality early care programs is unattainable for many low-income children who are most at-risk. According to the National Women's Law Center, in 2006, 75 percent of states would not offer a child care subsidy to a family of three earning more than $32,200 a year. During the 2007 legislative session, the State of Missouri increased their maximum income criteria for subsidy eligibility for the first time since 1999, from 105% to 126% of the federal poverty level, moving the state from 50th in the nation to 46th. Over the next four years, 400,000 children are expected to loose their subsidy assistance as funding to the Child Care Development Block Grant (CCDBG) will remain steady with no increases for inflation. These are in addition to the 250,000 children who have lost their coverage since 2000 due to overall decreased funding of the CCDBG.
** No licensed child care capacity available in this ZIP code.


text:
Authorities estimate 2.3 million people affected by earthquake in Mexico
The number of people potentially affected by the earthquake of magnitude 8.2 of September 7 in Mexico amounts to around 2.3 million, while the death toll remains at 90, official sources said today.
The governor of Oaxaca, Alejandro Murat, confirmed in a press conference in the municipality of Ixtepec that the number of people died due to the quake in that southern state remains at 71.
"There are 41 municipalities that have been affected by this earthquake. We are talking about more than 800,000 citizens who were potentially affected," he said.
Murat said that the municipalities with the most damage are Juchitán, Unión Hidalgo, Ixtalpetec and Astaca. "We are still evaluating the other municipalities that also had important impacts," he said.
The governor also reported that there are 324 schools affected, 42 of them with total damages, reason why the suspension of classes will be kept tomorrow in the region of the Isthmus of Tehuantepec "to continue with the evaluations and to avoid risks".
Meanwhile, the Secretary of Public Education of the Federal Government, Aurelio Nuño, told Milenio newspaper that there will also be no classes tomorrow in the southeastern state of Chiapas, where there is severe damage in 47 schools and minor damages in 900.
"We will be enabling alternate sites to avoid delays in the courses," because "there are schools that have relatively minor damages that will be repaired more or less quickly and others that are, at least, will have to be completely rebuilt," he said.
The government of Chiapas reported that the number of houses affected by the earthquake reached 40,000 and the number of deaths remains at 15.
He said that although there are reports from the 122 municipalities in the state, most of the damage is concentrated in 82 locations. Some of the municipalities with the largest number of damaged houses are Tonalá, Cintalapa, Parral, Venustiano Carranza, Acapetahua, Emiliano Zapata, Tuxtla Gutierrez, Tapachula, Suchiate, Pijijiapan and Comitán.
The number of victims in the state of maintains in 1 million 479,575 people, so the total is approximately 2.3 million.
Apart from the fatalities in Oaxaca and Chiapas, the state of Tabasco (southeast) also has four deaths from the earthquake, National Civil Defense Coordinator Luis Felipe Puente reported Saturday.
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The Bourne family is associated both with pottery and Methodism in Belper and Derbyshire. Hugh Bourne (1772–1852) was the joint founder of Primitive Methodism, the largest offshoot of Wesleyan Methodism and, in the mid nineteenth century, an influential Protestant Christian movement in its own right.
Hugh Bourne was born on 3 April 1772 at Ford Hayes Farm, Ford Hayes Lane, Bucknall, now within the present-day boundaries of Stoke-on-Trent, Staffordshire. He was the son of Joseph and Ellen Bourne. In 1788, after basic training as a carpenter, Hugh moved to the nearby mining village of Bemersley (in the north-eastern fringe of the present-day Stoke-on-Trent) and was apprenticed to his uncle as a wheelwright. After 'serving his time' learning the trade, Hugh specialised principally in making and repairing windmill and watermill wheels.
Bourne's conversion at the age of twenty seven led him to join the local Wesleyan society at Burslem, one of the historical six towns of the City of Stoke-on-Trent. He continued as a wheelwright but, after a period of group bible study, soon became a Methodist lay-preacher.
One of the main features of Primitive Methodist evangelism was an all-day, open-air prayer and preaching meeting. Unfortunately, these American-style meetings were viewed with great suspicion by the Methodist authorities and a ban on holding such gatherings was imposed. Having ignored this ruling, both Bourne and Clowes were eventually expelled from the Methodist Church (in 1808 and 1810 respectively). Despite this set-back, the new movement continued to grow, spreading throughout the Midlands and the North of England, following the line of the River Trent to Hull, where Clowes died and is buried.
This J. Bourne, printer, is a preacher, together with his brother, Hugh Bourne, under both of whose labours has arisen the Primitive Connexion.... Missionary exertions, which had been declining, were revived at Belper " very powerfully," while "the praying people, in returning home, were accustomed to sing through the streets of Belper!" It is added, that "this circumstance procured them the name of Ranters, and the name of Ranter, which first arose on this occasion, afterwards spread very extensively." The work, we are told, then spread to Derby and Nottingham, whence circuits were established, one circuit having been hitherto sufficient for the Connexion.
Belper was made a circuit of the Methodist preachers and they and the Bourne family established a chapel for worship on Kilburn Road, Belper, called Pottery Methodist Chapel on the road directly opposite the old Belper Pottery site. Belper Pottery Methodist Church is Grade II listed and the chapel and school were built in 1812 and 1878. The name "Pottery" echoes the predecessor of Bourne's Pottery at Denby which formerly stood in this locality.
This story happened around 1816 at Belper in Derbyshire in the English Midlands. It concerns John Benton, a Primitive Methodist open-air preacher and missionary. At this time, the movement was beginning to expand rapidly, using open-air preaching throughout the counties of Cheshire, Staffordshire and Derbyshire.
This style of preaching was not without its challenges. One of the hazards of open-air preaching was opposition and persecution from rabble-rousers and gangs. Primitive Methodist preachers often faced name-calling, violence and disruption in their public meetings. However not all opposition went in the way desired by their opponents. This is just one of many stories of how the plans of those who opposed the Primitive Methodist preachers came undone.
One evening Benton and a group of young converts entered the town of Belper, singing as they approached the market-place. They intended to preach the gospel and "mission" the town. Hundreds of people gathered to hear the missionary preacher and his associates. As well as those who came to hear them, a rabble also gathered to cause trouble.
The rabble was organised by a ringleader, intent on disrupting the preaching. His plan was a simple one. He had taken a bucket, and mixed in it blood and excrement from an animal that had been killed. His intention was to scale a ladder at the back of the building and pour the bucket of filth on the preacher's head from the front of the building.
The ringleader climbed the ladder and tried to place the bucket on the ridge of the building. As he did so, his foot slipped, and the whole of the contents came down on his own head, and he could only get down the ladder with great difficulty.
This was a great source of laughter and mirth for his fellow rabble rousers, and he was so humiliated by the whole process, that the next time Benton came to preach he gave him a sober hearing. So the moral of this story is: when opposing God, be prepared for the unexpected.
A deed of 1737 records the presence of a 'Potters Acre' at Belper. In 1772 William Bourne, described as a potter of Belper, took out an insurance policy which included £50 for a workhouse and workrooms. A jug dated 1765 is thought possibly to be attributable to Belper; more certain are two pieces of 1775 which have both Belper and the date incised on them. Various other dated pieces of the late 18th century have survived (Oswald 1982).
Pottery manufacture, already established by the 1760s and probably before continued into the early 19th century. The pre-existing works at Belper Pottery were taken over about 1800 by William Bourne. The local clay was suitable for brown kitchenware, such as bowls, dishes and water-jugs. For better quality articles, clay was brought from Derby or Staffordshire.
In 1812 Joseph Bourne added the existing Denby Pottery to his business and he operated on both sites until 1834, when the Belper works were closed and all production carried on at Denby Giles et al 2000).
The famous pottery at Denby was established in 1809, and its origins were documented in some detail by Llewellynn Jewitt in his book Ceramic Art of Great Britain first published in 1877.
"The works were commenced in 1809 by a Mr. Jager, on the estate of W. Drury Lowe, Esq., where, some time before, a valuable and extensive bed of clay had been found to exist. This clay, previous to the establishment of the Denby Works, was used at the Belper Pottery for the manufacture of stoneware ink, blacking, and other bottles. … In 1812 Joseph Bourne, son of William Bourne, of the Belper Pottery, succeeded Mr. Jaeger and the Belper and Denby works were carried on simultaneously until 1834 when the Belper Works were discontinued, and the plant and workpeople moved to Denby."
Other sources indicate that William Bourne gave the task of managing the new business to two of his sons John and Joseph Bourne, perhaps while he continued at the Belper Pottery. The business was originally known as J. & J. Bourne, however, John Bourne died in 1819 and Joseph Bourne then continued the business in his own name. The nearby Codnor Park Works were acquired in 1833 and the Shipley Pottery in 1845 and both were eventually closed and their plant and staff moved to the Denby site.


text:
Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency
Willemijn J. van Rijt, Emmalie A. Jager, Derk P. Allersma, A. Çiğdem Aktuğlu Zeybek, Kaustuv Bhattacharya, François Guillaume Debray, Carolyn J. Ellaway, Matthias Gautschi, Michael T. Geraghty, David Gil-Ortega, Austin A. Larson, Francesca Moore, Eva Morava, Andrew A. Morris, Kimihiko Oishi, Manuel Schiff, Sabine Scholl-Bürgi, Michel C. Tchan, Jerry Vockley, Peter WittersSaskia B. Wortmann, Francjan van Spronsen, Johan L.K. Van Hove, Terry G.J. Derks
Purpose: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a life-threatening, ultrarare inborn error of metabolism. Case reports described successful D,L-3-hydroxybutyrate (D,L-3-HB) treatment in severely affected MADD patients, but systematic data on efficacy and safety is lacking. Methods: A systematic literature review and an international, retrospective cohort study on clinical presentation, D,L-3-HB treatment method, and outcome in MADD(-like) patients. Results: Our study summarizes 23 MADD(-like) patients, including 14 new cases. Median age at clinical onset was two months (interquartile range [IQR]: 8 months). Median age at starting D,L-3-HB was seven months (IQR: 4.5 years). D,L-3-HB doses ranged between 100 and 2600 mg/kg/day. Clinical improvement was reported in 16 patients (70%) for cardiomyopathy, leukodystrophy, liver symptoms, muscle symptoms, and/or respiratory failure. D,L-3-HB appeared not effective for neuropathy. Survival appeared longer upon D,L-3-HB compared with historical controls. Median time until first clinical improvement was one month, and ranged up to six months. Reported side effects included abdominal pain, constipation, dehydration, diarrhea, and vomiting/nausea. Median D,L-3-HB treatment duration was two years (IQR: 6 years). D,L-3-HB treatment was discontinued in 12 patients (52%). Conclusion: The strength of the current study is the international pooling of data demonstrating that D,L-3-HB treatment can be effective and safe in MADD(-like) patients.
Genetics in Medicine
Published - May 1 2020
D,L-3-hydroxybutyrate treatment
fatty acid oxidation
inborn error of metabolism
ketone bodies
multiple acyl-CoA dehydrogenase deficiency
Dive into the research topics of 'Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency'. Together they form a unique fingerprint.
Multiple Acyl Coenzyme A Dehydrogenase Deficiency Medicine & Life Sciences 100%
3-Hydroxybutyric Acid Medicine & Life Sciences 75%
Inborn Errors Metabolism Medicine & Life Sciences 12%
Constipation Medicine & Life Sciences 9%
Cardiomyopathies Medicine & Life Sciences 9%
Age of Onset Medicine & Life Sciences 9%
van Rijt, W. J., Jager, E. A., Allersma, D. P., Aktuğlu Zeybek, A. Ç., Bhattacharya, K., Debray, F. G., Ellaway, C. J., Gautschi, M., Geraghty, M. T., Gil-Ortega, D., Larson, A. A., Moore, F., Morava, E., Morris, A. A., Oishi, K., Schiff, M., Scholl-Bürgi, S., Tchan, M. C., Vockley, J., ... Derks, T. G. J. (2020). Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency. Genetics in Medicine, 22(5), 908-916. https://doi.org/10.1038/s41436-019-0739-z
Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency. / van Rijt, Willemijn J.; Jager, Emmalie A.; Allersma, Derk P. et al.
In: Genetics in Medicine, Vol. 22, No. 5, 01.05.2020, p. 908-916.
van Rijt, WJ, Jager, EA, Allersma, DP, Aktuğlu Zeybek, AÇ, Bhattacharya, K, Debray, FG, Ellaway, CJ, Gautschi, M, Geraghty, MT, Gil-Ortega, D, Larson, AA, Moore, F, Morava, E, Morris, AA, Oishi, K, Schiff, M, Scholl-Bürgi, S, Tchan, MC, Vockley, J, Witters, P, Wortmann, SB, van Spronsen, F, Van Hove, JLK & Derks, TGJ 2020, 'Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency', Genetics in Medicine, vol. 22, no. 5, pp. 908-916. https://doi.org/10.1038/s41436-019-0739-z
van Rijt WJ, Jager EA, Allersma DP, Aktuğlu Zeybek AÇ, Bhattacharya K, Debray FG et al. Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency. Genetics in Medicine. 2020 May 1;22(5):908-916. doi: 10.1038/s41436-019-0739-z
van Rijt, Willemijn J. ; Jager, Emmalie A. ; Allersma, Derk P. et al. / Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency. In: Genetics in Medicine. 2020 ; Vol. 22, No. 5. pp. 908-916.
@article{0d73358219c5451a83e7d9f4380b2edb,
title = "Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency",
abstract = "Purpose: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a life-threatening, ultrarare inborn error of metabolism. Case reports described successful D,L-3-hydroxybutyrate (D,L-3-HB) treatment in severely affected MADD patients, but systematic data on efficacy and safety is lacking. Methods: A systematic literature review and an international, retrospective cohort study on clinical presentation, D,L-3-HB treatment method, and outcome in MADD(-like) patients. Results: Our study summarizes 23 MADD(-like) patients, including 14 new cases. Median age at clinical onset was two months (interquartile range [IQR]: 8 months). Median age at starting D,L-3-HB was seven months (IQR: 4.5 years). D,L-3-HB doses ranged between 100 and 2600 mg/kg/day. Clinical improvement was reported in 16 patients (70%) for cardiomyopathy, leukodystrophy, liver symptoms, muscle symptoms, and/or respiratory failure. D,L-3-HB appeared not effective for neuropathy. Survival appeared longer upon D,L-3-HB compared with historical controls. Median time until first clinical improvement was one month, and ranged up to six months. Reported side effects included abdominal pain, constipation, dehydration, diarrhea, and vomiting/nausea. Median D,L-3-HB treatment duration was two years (IQR: 6 years). D,L-3-HB treatment was discontinued in 12 patients (52%). Conclusion: The strength of the current study is the international pooling of data demonstrating that D,L-3-HB treatment can be effective and safe in MADD(-like) patients.",
keywords = "D,L-3-hydroxybutyrate treatment, fatty acid oxidation, inborn error of metabolism, ketone bodies, multiple acyl-CoA dehydrogenase deficiency",
author = "{van Rijt}, {Willemijn J.} and Jager, {Emmalie A.} and Allersma, {Derk P.} and {Aktuğlu Zeybek}, {A. {\c C}iğdem} and Kaustuv Bhattacharya and Debray, {Fran{\c c}ois Guillaume} and Ellaway, {Carolyn J.} and Matthias Gautschi and Geraghty, {Michael T.} and David Gil-Ortega and Larson, {Austin A.} and Francesca Moore and Eva Morava and Morris, {Andrew A.} and Kimihiko Oishi and Manuel Schiff and Sabine Scholl-B{\"u}rgi and Tchan, {Michel C.} and Jerry Vockley and Peter Witters and Wortmann, {Saskia B.} and {van Spronsen}, Francjan and {Van Hove}, {Johan L.K.} and Derks, {Terry G.J.}",
note = "Funding Information: The authors thank Katinka A.M. Mulder, legal advisor—research contracts, for her contribution to the realization of the consortium agreement. Pharmaceutical industries did not play any role in this study. The MD/PhD scholarships of W.J.v.R. and E.A.J. are funded by the Junior Scientific Masterclass from the University of Groningen, University Medical Center Groningen (MD/PhD 15–30, MD/PhD 18–55, respectively). J.V. is supported in part by National Institutes of Health (NIH) grant R01-DK78755. The sources of funding had no involvement in the study design; data collection, analysis, and interpretation; reporting of the results; or in the decision to submit the paper for publication. Publisher Copyright: {\textcopyright} 2020, The Author(s).",
journal = "Genetics in Medicine",
T1 - Efficacy and safety of D,L-3-hydroxybutyrate (D,L-3-HB) treatment in multiple acyl-CoA dehydrogenase deficiency
AU - van Rijt, Willemijn J.
AU - Jager, Emmalie A.
AU - Allersma, Derk P.
AU - Aktuğlu Zeybek, A. Çiğdem
AU - Bhattacharya, Kaustuv
AU - Debray, François Guillaume
AU - Ellaway, Carolyn J.
AU - Gautschi, Matthias
AU - Geraghty, Michael T.
AU - Gil-Ortega, David
AU - Larson, Austin A.
AU - Moore, Francesca
AU - Morava, Eva
AU - Morris, Andrew A.
AU - Oishi, Kimihiko
AU - Schiff, Manuel
AU - Scholl-Bürgi, Sabine
AU - Tchan, Michel C.
AU - Vockley, Jerry
AU - Witters, Peter
AU - Wortmann, Saskia B.
AU - van Spronsen, Francjan
AU - Van Hove, Johan L.K.
AU - Derks, Terry G.J.
N1 - Funding Information: The authors thank Katinka A.M. Mulder, legal advisor—research contracts, for her contribution to the realization of the consortium agreement. Pharmaceutical industries did not play any role in this study. The MD/PhD scholarships of W.J.v.R. and E.A.J. are funded by the Junior Scientific Masterclass from the University of Groningen, University Medical Center Groningen (MD/PhD 15–30, MD/PhD 18–55, respectively). J.V. is supported in part by National Institutes of Health (NIH) grant R01-DK78755. The sources of funding had no involvement in the study design; data collection, analysis, and interpretation; reporting of the results; or in the decision to submit the paper for publication. Publisher Copyright: © 2020, The Author(s).
N2 - Purpose: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a life-threatening, ultrarare inborn error of metabolism. Case reports described successful D,L-3-hydroxybutyrate (D,L-3-HB) treatment in severely affected MADD patients, but systematic data on efficacy and safety is lacking. Methods: A systematic literature review and an international, retrospective cohort study on clinical presentation, D,L-3-HB treatment method, and outcome in MADD(-like) patients. Results: Our study summarizes 23 MADD(-like) patients, including 14 new cases. Median age at clinical onset was two months (interquartile range [IQR]: 8 months). Median age at starting D,L-3-HB was seven months (IQR: 4.5 years). D,L-3-HB doses ranged between 100 and 2600 mg/kg/day. Clinical improvement was reported in 16 patients (70%) for cardiomyopathy, leukodystrophy, liver symptoms, muscle symptoms, and/or respiratory failure. D,L-3-HB appeared not effective for neuropathy. Survival appeared longer upon D,L-3-HB compared with historical controls. Median time until first clinical improvement was one month, and ranged up to six months. Reported side effects included abdominal pain, constipation, dehydration, diarrhea, and vomiting/nausea. Median D,L-3-HB treatment duration was two years (IQR: 6 years). D,L-3-HB treatment was discontinued in 12 patients (52%). Conclusion: The strength of the current study is the international pooling of data demonstrating that D,L-3-HB treatment can be effective and safe in MADD(-like) patients.
AB - Purpose: Multiple acyl-CoA dehydrogenase deficiency (MADD) is a life-threatening, ultrarare inborn error of metabolism. Case reports described successful D,L-3-hydroxybutyrate (D,L-3-HB) treatment in severely affected MADD patients, but systematic data on efficacy and safety is lacking. Methods: A systematic literature review and an international, retrospective cohort study on clinical presentation, D,L-3-HB treatment method, and outcome in MADD(-like) patients. Results: Our study summarizes 23 MADD(-like) patients, including 14 new cases. Median age at clinical onset was two months (interquartile range [IQR]: 8 months). Median age at starting D,L-3-HB was seven months (IQR: 4.5 years). D,L-3-HB doses ranged between 100 and 2600 mg/kg/day. Clinical improvement was reported in 16 patients (70%) for cardiomyopathy, leukodystrophy, liver symptoms, muscle symptoms, and/or respiratory failure. D,L-3-HB appeared not effective for neuropathy. Survival appeared longer upon D,L-3-HB compared with historical controls. Median time until first clinical improvement was one month, and ranged up to six months. Reported side effects included abdominal pain, constipation, dehydration, diarrhea, and vomiting/nausea. Median D,L-3-HB treatment duration was two years (IQR: 6 years). D,L-3-HB treatment was discontinued in 12 patients (52%). Conclusion: The strength of the current study is the international pooling of data demonstrating that D,L-3-HB treatment can be effective and safe in MADD(-like) patients.
KW - D,L-3-hydroxybutyrate treatment
KW - fatty acid oxidation
KW - inborn error of metabolism
KW - ketone bodies
KW - multiple acyl-CoA dehydrogenase deficiency
JO - Genetics in Medicine
JF - Genetics in Medicine


Getting started on another one. 1/2″ foil back insulation and a 60 MIL PVC rubber is the modus operandi on this job.
New decking being installed. Decking installed. Ready for the new roof.
Severely deteriorated roof deck at Husqvarna.


The Yiribana Gallery at the Art Gallery of NSW is the home of the Aboriginal and Torres Strait Islander art collection. It presents works from across the country in a diverse range of media and range of styles. The current selection is centred on family - whether this be family inheritance, family experiences or familial connections to country. In addition, numerous works by artists from within the same family are presented, highlighting both the connections and innovations across generations as works by parents and their children, or husbands and wives, are shown alongside on another.
Pitjantjatjara artists Mumu Mike Williams, Willy Muntjantji Martin and Sammy Dodd have created an artwork that discusses land rights and law. Spears have an important symbolic role in law.
Count how many spears you can see. Include both painted and carved spears.
Design a protest poster to communicate an issue that is important to you.
Locate the Anangu Pitjantjatjara Yankunyjtjatjara lands on a map. Find out about the important plants in this region.
Ngarrindjeri artist Ian Abdulla combines pictures and words to represent childhood memories of life in the Riverland region of rural South Australia.
Find the children cooking toast and swimming in the river. How many birds can you spot?
Draw a map of you journey to school.
Draw a cherished family memory. Write a short story explaining your drawing.
Gumatj artist Gulumbu Yunupingu has covered this larrakitj (hollow log) in a field of stars.
Look at the sculpture from different angles. What do you notice about the patterns on the surface?
Imagine yourself as one of Yunupingu's stars in the night sky. Draw the planets, stars and floating objects you see around you.
Photograph the stars in the night sky over two weeks. What has stayed the same and what has changed?
Kudjla/Gangalu artist Daniel Boyd based this painting on a photograph that shows two figures seated on the ground, with one watching the other light a fire with a firestick.
Look at the painting close up and far away. What differences do you notice?
Draw yourself with a friend. Focus on showing light and shade.
Find out about the use of firesticks in Australia.
Warra Warra artist Susan Balbunga has used pandanus leaves to weave a bamugura (covering), which protects sleeping babies from milkmilk (mosquitoes) and gatjirri (sandflies).
Look at the shadow cast by the bamugura.
Imagine yourself lying underneath the bamugura looking up at the sky. Draw what you see.
Use a torch to cast shadows of household objects against a wall. Notice the patterns and shapes created.
Gija artist Lena Nyadbi paints stories associated with her country around Warmun (Turkey Creek) in Western Australia.
Find the hideout of Binyjirrminy (the bat) depicted in this painting.
Draw another animal that you might find taking shelter in a cave.
Design and build your own hideout.
Bidigal artist Esme Timbery learnt shell work as a young girl from her mother, grandmothers and aunts by first sorting the shells by type, size and colour.
Notice the different types of shells on this sculpture. Talk about the shape, size and colour of each type.
Draw a landscape where you might find shells. Include plants and animals you would find there too.
Construct a model of your home using materials found inside and outside of your home.


Republic of Ireland boss Martin O'Neill opts to keep striker Daryl Murphy in his starting lineup for the second leg of the World Cup playoff with Denmark.
Republic of Ireland boss Martin O'Neill has opted to keep striker Daryl Murphy in his starting lineup for the second leg of the World Cup playoff with Denmark.
After Saturday's goalless draw in Copenhagen, Murphy's place in attack had been under threat, but O'Neill has decided to keep faith in the Nottingham Forest forward.
The only change to the starting lineup sees David Meyler - who was suspended for the first leg - replace Callum O'Dowda on the right flank.
Denmark manager Age Hareide has made two alterations to his team, with Andreas Christensen and Yussuf Poulsen being brought into the team.
Peter Ankersen and Andreas Cornelius are the players to make way, with Nicklas Bendtner having to make do with a place on the bench.