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Prince Harry, Meghan sign up to exit deal; give up royal titles
0 0 Sunday, 19 January 2020 Edit this post
London: Prince Harry and his wife Meghan Markle, the Duke and Duchess of Sussex, have signed up to a formal exit deal from the royal fam...
London: Prince Harry and his wife Meghan Markle, the Duke and Duchess of Sussex, have signed up to a formal exit deal from the royal family, which will see them forsake their His and Her Royal Highness (HRH) titles and will no longer receive UK taxpayers' funding for their duties.
The deal, which comes into effect by spring in a few weeks' time, means the couple will no longer be representing the Queen in an official capacity.
"The Sussexes will not use their HRH titles as they are no longer working members of the royal family," Buckingham Palace said in a statement on Saturday night.
Queen Elizabeth II said the agreement followed months of discussions and was a "constructive and supportive" way forward for her grandson and his family.
"Harry, Meghan and Archie will always be much loved members of my family," the 93-year-old monarch's personal statement read.
"I recognise the challenges they have experienced as a result of intense scrutiny over the last two years and support their wish for a more independent life," she says, thanking the couple for their work for UK and across the Commonwealth.
In a special message for Markle, she said: "I am... particularly proud of how Meghan has so quickly become one of the family. It is my whole family's hope that today's agreement allows them to start building a happy and peaceful new life".
The palace confirmed that the couple were required to withdraw from royal duties, including official military appointments.
"While they can no longer formally represent the Queen, the Sussexes have made clear that everything they do will continue to uphold the values of Her Majesty," the palace said.
It added that the pair would continue to maintain their private patronages and associations.
The couple intend to repay 2.4 million pounds of UK taxpayer money for the refurbishment of Frogmore Cottage, which will remain their UK family home as they split their time between Britain and Canada.
The palace has declined to comment on security arrangements and who would foot that bill for the couple in future, an issue that has been at the centre of much of the debate since they announced their decision to step back as senior royals earlier this month.
Harry, 35, and Meghan, 38, issued their own update on their official Sussex Royal website, which has been updated to remove references to the HRH titles on the opening page.
"We now plan to balance our time between the United Kingdom and North America, continuing to honour our duty to The Queen, the Commonwealth, and our patronages.
"This geographic balance will enable us to raise our son with an appreciation for the royal tradition into which he was born, while also providing our family with the space to focus on the next chapter, including the launch of our new charitable entity," the statement on their website reads.
Meghan is already in Canada with the couple's eight-month-old son Archie and some reports indicate she may fly back briefly for some pending royal engagements until the new agreement formally kicks in on an unspecified date in spring which begins towards the end of March in the UK.
Meanwhile, Prince Harry will continue to perform royal duties until that time, which includes at a summit for African leaders in London on Monday.
He will eventually step back permanently, giving up his military roles as Captain General of the Royal Marines (a post passed to him by the Duke of Edinburgh), Honorary Air Commandant at RAF Honiton, and Commodore-in-Chief, Small Ships and Diving.
Under what is being dubbed as a "hard Megxit", the couple will also lose their relatively new roles as Youth Ambassadors of the Commonwealth.
However, as part of keeping their private patronages, they are expected to remain President and Vice President of the Queen's Commonwealth Trust.
"As agreed in this new arrangement, they understand that they are required to step back from royal duties, including official military appointments. They will no longer receive public funds for royal duties," the palace statement specifies.
This gives the couple the financial independence they had sought and means they no longer have access to a share of the UK's taxpayer-funded Sovereign Grant the 82.2-million pounds that the royal family receives from the UK Treasury each year.
According to some reports, the couple will continue to receive an undisclosed sum of "private financial support" from Harry's father Prince Charles.
There are still some question marks over the couple's future status, including what their tax and immigration status will be in the UK and Canada.
It is unclear whether former American actress Markle still intends to gain British citizenship, which she had initiated when she got engaged to Harry in November 2017 and would require her to spend a certain amount of time in the UK.
-Source: News Agency
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SAN DIEGO--(BUSINESS WIRE)--Feb. 25, 2016-- La Jolla Pharmaceutical Company (NASDAQ: LJPC) (the Company or La Jolla), a leader in the development of innovative therapies intended to significantly improve outcomes in patients suffering from life-threatening diseases, today reported fourth quarter and full year 2015 financial results and highlighted 2015 corporate progress.
The ATHOS (Angiotensin II for the Treatment of High-Output Shock) 3 trial, La Jolla's multicenter, randomized, double-blind, placebo-controlled, Phase 3 clinical trial of LJPC-501, La Jolla's proprietary formulation of angiotensin II, in catecholamine-resistant hypotension (CRH) was initiated in March 2015. The initiation of the ATHOS 3 trial followed the reaching of an agreement with the U.S. Food and Drug Administration (FDA) on a Special Protocol Assessment (SPA), in which the agreed-upon primary efficacy endpoint in ATHOS 3 is increase in blood pressure. ATHOS 3 is enrolling as planned, and results are expected by the end of 2016.
A multicenter, open-label, dose-escalation Phase 1 clinical trial of LJPC-401, the Company's novel formulation of hepcidin, in patients at risk for iron overload due to conditions such as hereditary hemochromatosis, beta thalassemia, sickle cell disease and myelodysplastic syndrome was initiated in October 2015. Interim results, reported in January 2016, suggested a dose-dependent reduction in serum iron following a single dose of LJPC-401. Additionally, the European Medicines Agency (EMA) Committee for Orphan Medicinal Products (COMP) designated LJPC-401 an orphan medicinal product for the treatment of beta thalassemia intermedia and major.
La Jolla entered into exclusive worldwide license agreements with the Indiana University Research and Technology Corporation and the University of Alabama at Birmingham to acquire intellectual property rights covering LJPC-30Sa and LJPC-30Sb in May 2015. LJPC-30Sa and LJPC-30Sb are La Jolla's next-generation gentamicin derivatives for the potential treatment of serious bacterial infections and rare genetic disorders, such as cystic fibrosis and Duchenne muscular dystrophy.
La Jolla completed a public offering of common stock in September 2015, whereby La Jolla received approximately $104.6 million, net of issuance costs. La Jolla finished 2015 with $126.5 million in cash and cash equivalents and believes this is sufficient to fund operations into 2018.
As of December 31, 2015, La Jolla had $126.5 million in cash and cash equivalents, compared to $48.6 million as of December 31, 2014. The increase in cash and cash equivalents was primarily due to cash provided by our common stock offering that was completed in September 2015, which was partially offset by net cash used for operating activities. Based on current operating plans and projections, La Jolla believes that its current cash and cash equivalents are sufficient to fund operations into 2018.
La Jolla's net cash used for operating activities for the three and twelve months ended December 31, 2015 was $8.5 million and $25.2 million, respectively, compared to net cash used for operating activities of $5.4 million and $12.9 million, respectively, for the same periods in 2014. La Jolla's net loss for the three and twelve months ended December 31, 2015 was $11.8 million and $41.9 million, or $0.69 per share and $2.68 per share, respectively, compared to a net loss of $6.8 million and $21.3 million, or $0.45 per share and $2.00 per share, respectively, for the same periods in 2014. During the three and twelve months ended December 31, 2015, La Jolla recognized contract revenue of approximately $0.4 million and $1.1 million, respectively, which was pursuant to a services agreement initiated in 2015 under which La Jolla provides research and development services to a related party. The net loss includes non-cash, share-based compensation expense of $2.8 million and $13.1 million for the three and twelve months ended December 31, 2015, respectively, compared to $2.5 million and $9.1 million of noncash, share-based compensation expense, respectively, for the same periods in 2014.
The increases in net cash used for operating activities and net loss in 2015 as compared to 2014 were primarily due to increased development costs associated with the Phase 3 clinical trial of LJPC-501 in catecholamine-resistant hypotension and the costs associated with the initiation of the Phase 1 clinical trial of LJPC-401 in iron overload. In addition, there were increases in personnel and related costs, which were mainly due to the hiring of additional personnel and increased facility costs to support the increased development activities.
This document contains forward-looking statements as that term is defined in the Private Securities Litigation Reform Act of 1995. These statements relate to future events or the Company's future results of operations. These statements are only predictions and involve known and unknown risks, uncertainties and other factors, which may cause actual results to be materially different from these forward-looking statements. The Company cautions readers not to place undue reliance on any such forward-looking statements, which speak only as of the date they were made. Certain of these risks, uncertainties, and other factors are described in greater detail in the Company's filings with the U.S. Securities and Exchange Commission (SEC), all of which are available free of charge on the SEC's web site www.sec.gov. These risks include, but are not limited to, risks relating to: the timing for commencement of clinical studies, the anticipated timing for completion of such studies, and the anticipated timing for regulatory actions; the success of future development activities; potential indications for which the Company's product candidates may be developed; and the expected duration over which the Company's cash balances will fund its operations. Subsequent written and oral forward-looking statements attributable to the Company or to persons acting on its behalf are expressly qualified in their entirety by the cautionary statements set forth in the Company's reports filed with the SEC. The Company expressly disclaims any intent to update any forward-looking statements.


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Posted in Elections, Govt Incompentece
Twenty Six Haitian-American Elected Officials Call on the State Department, the UN, OAS, CARICOM, IADB, IMF and World Bank to Act Immediately on the Dominican Republic
` February 28, 2014
Honorable Joseph Champagne, Mayor of South Toms River, New Jersey
The National Haitian American Elected Officials Network (NHAEON) strongly condemns the Dominican Republic court ruling (Sentencia 168-13) which renders stateless thousands of Dominicans, mainly of Haitian and Caribbean origin.
Media Contact: Joseph Makhandal Champagne, Jr., Esq., Chair Tel: 732-240-0030 and email: nhaeon.chairman@gmail.com
The ruling officially states that any Dominican citizen without one parent of Dominican nationality will have their citizenship stripped retroactively to 1929. This ruling violates the Dominican constitution and a number of international conventions.
Consider the vast implications of this ruling. Without citizenship, these Dominicans have no property rights; they are unable to use hospital facilities their children cannot go to school; their passports are void and they cannot travel. They are in limbo. An 80-year old grandmother living in the Dominican Republic for generations just lost everything – as have her children and grandchildren. Most concerning to my organization is that a disproportionate number of Dominicans affected by this ruling are black and of Haitian descent.
Multilateral institutions, including the Caribbean Community and Common Market (CARICOM), Organization of American States (OAS), the United Nations (UN), and the Inter American Human Rights Commission, have condemned the decision. Haitian President Michel Martelly addressed the OAS on February 7, 2014 calling for constant vigilance on this issue (https://www.youtube.com/watch?v=8kk8Byb-kQA&list=PLkh9EPEuEx2sNOv3Z8kwhcHuDZXHHQTt8&index=3). Twelve days after that speech, CARICOM countries called on the OAS Permanent Council to consider the report of the Inter American Commission on Human Rights calling for the Dominican Republic to respect its international obligations (https://www.youtube.com/watch?v=zq34GEHxU1E&index=2&list=PLkh9EPEuEx2sNOv3Z8kwhcHuDZXHHQTt8).
Many human rights organizations have joined the condemnation, including Amnesty International and the Robert Kennedy Center for Human Rights and Justice. Human rights activist and winner of the 2010 Nobel Prize for Literature, Mario Vargas Llosa, has likened the Dominican court ruling to tactics used by the Nazis and the brutal Apartheid regime in South Africa. Unfortunately for Haitians, who are the main ethnic group targeted by this ruling, there is a troubling historic precedence underpinning this comparison. In 1937, Dominican President Rafael Trujillo directed the purge of black Haitian workers and murdered as many as 40,000 Haitians without repercussion.
In the face of international pressure, the Dominican Government has only minimally responded. They have engaged the Haitian government in a bilateral dialogue, which has resulted in no serious solutions to date. Rather, the Dominicans have focused on a tangential issue, namely "regularizing" undocumented workers, and have issued two decrees that provide papers to those citizens. Undocumented workers are not the core issue. The rendering stateless of tens of thousands Dominicans is the core issue.
NHAEON is calling upon multilateral institutions, the Dominican and Haitian Diaspora, as well as human rights groups, and the global community to mobilize against this state-sponsored ethnic cleansing of Dominicans of Haitian and Caribbean descent by calling for the following actions:
1) UN Security Council, the Secretary General and the Organizations of American States officially condemn the ruling of the Dominican court; 2) Additional efforts by the CARICOM to suspend Dominican Republic participation in multilateral organizations, including the OAS, UN, the African Union, European Union, and PetroCaribe. 3) Call for the World Bank, International Monetary Fund and the Inter American Development Bank to consider sanctions; 4) Appeal for U.S. Diplomatic intervention and for Haitian Americans to build coalitions with our friends and allies in the Congressional Black Caucus, the Latino Caucus, the Progressive Caucus, the NAACP, Urban League, and religious groups to join us in protecting the citizenship of all Dominicans; and, 5) Mobilize the Dominican and Haitian Diaspora to boycott the Dominican government and businesses and request host nations to condemn the Dominican ruling and impose trade sanctions.
ABOUT NHAEON National Haitian American Elected Officials Network in the United States (NHAEON) is a non-partisan coalition determined to promote Haitian culture, education, welfare and well being while improving relations between the United States and Haiti. NHAEON is committed to bringing a renewed national and local focus on key legislative, diplomatic, security, economic and human rights issues affecting Haiti.
State Department Human Rights on the Dominican Republic, see: http://www.state.gov/j/drl/rls/hrrpt/humanrightsreport/index.htm#wrapper
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redpajama_set_name: RedPajamaCommonCrawl


Originally, the meridians (sometimes called acupuncture lines) of our bodies were connected to the grid that surround the planet and cross all known places of power, such as Machu Picchu and Sedona.
This grid is designed to continue out and connect with a much larger grid, connecting us with the entire universe. Each of our bodies contains its own set of energy lines and points and although they are only reminiscent of what they once were, these lines and points continue to serve us as an interface with the universe. This interface is a channel that facilitates our communication of energy, light and information between the big and the small, the macrocosm and the microcosm, the universe and humanity.
According to the theory, at one time we were disconnected from these lines and we lost access to the totality of our inherent connection with the universe, distancing ourselves from our previous rhythm of rapid and expansive evolution.
The Personal Reconnection® is carried out in 2 sessions. There must be a night of rest between them, in which you can relax and enjoy your process.
The sessions are from Monday to Friday from 12:00 am to 08:00 and last from 30 to 45 minutes on a stretcher. We coordinate by phone to give you day and time once you have booked session.


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United States: Selling QSBS Before Satisfying Section 1202's Five-Year Holding Period Requirement?
by Scott W. Dolson
A stockholder must hold QSBS for more than five years in order to take advantage of Section 1202's generous gain exclusion.1 Here are some steps to consider if it appears you will be selling your QSBS before satisfying that five-year holding period requirement:
This is one in a series of articles addressing planning issues relating to qualified small business stock (QSBS) and the workings of Sections 1202 and 1045 of the Internal Revenue Code.
1. Postpone the QSBS Sale.
Consider working with the buyer (or your company's management) to postpone the closing of your stock sale until you have satisfied Section 1202's five-year holding period requirement. Depending on how long your sale must be postponed, possible planning suggestions include signing a sale agreement with a deferred (later) closing date, signing a sale agreement coupled with an agreement to have the buyer operate the business under a management arrangement until stockholders are past the required five-year holding period, or entering into a joint venture arrangement with the buyer, followed by the buyer's purchase of the company's QSBS after the five-year holding period requirement is satisfied. Of course, these alternatives do introduce the business risk that a sale delayed may become a sale termination.
2. Exchange QSBS for Buyer Stock.
Section 1202 allows holders of QSBS to exchange their stock for other stock (either QSBS or non-QSBS) in a Section 351 tax-free exchange or Section 368 tax-free reorganization. In these tax-free transactions, the holding period of the original QSBS is tacked onto the holding period for the replacement stock, which can then be held until the combined holding period satisfies Section 1202's five-year requirement. The holder will be positioned to eventually claim Section 1202's gain exclusion when the replacement QSBS is sold if the tax-free transaction involved the exchange of original QSBS for replacement QSBS. If the replacement stock is non-QSBS, then the Section 1202 gain exclusion will apply to the gain deferred when the QSBS was exchanged for the non-QSBS and any additional appreciation will qualify for long-term capital gains treatment. Unfortunately, if QSBS is exchanged for LLC or LP (partnership) interests in a tax-free Section 721 exchange, neither the LLC/LP nor the stockholder of the original QSBS will be able to claim Section 1202's gain exclusion with respect to the former QSBS.
3. Reinvest QSBS Sales Proceeds Into Other QSBS Under Section 1045.
QSBS sales proceeds can be rolled over tax-free into other QSBS under Section 1045 if the rollover occurs during the 60-day period beginning on the date of the sale of the original QSBS. Sellers of QSBS can reinvest their sales proceeds into a common or preferred stock investment in an existing qualified small business. The holding period for the original QSBS is tacked onto the holding period for the replacement QSBS. See point #4 below for a possible solution if no acceptable investment opportunity becomes available during the short 60-day window. A previous article Advanced Section 1045 Planning addresses Section 1045 planning in further detail.
4. Reinvest QSBS Sales Proceeds Into QSBS of a Newly-Organized C Corporation.
We work regularly with sellers of original QSBS who decide to reinvest their QSBS proceeds under Section 1045 in a newly-organized C corporation. This new C corporation issues QSBS and then uses the contributed proceeds to either (1) undertake start-up and/or R&D activities associated with creating a profitable qualified small business from scratch, or (2) undertake a search to identify and purchase the assets or equity of an existing qualified small business. If this route is taken, we assist entrepreneurs and investors with their efforts to comply with the complicated requirements of Sections 1202 and 1045, including developing and implementing business plans and complying with each of Section 1202 eligibility requirements. These holders of replacement QSBS can eventually claim Section 1202's gain exclusion when they sell their replacement QSBS or liquidate the corporation if the venture fails to meet expectations. Like any start-up venture, some issuers of replacement QSBS will be profitable and some will not succeed.
5. If QSBS Is Sold by a Partnership, Either the Partnership or Its Partners Can Elect to Reinvest the QSBS Sales Proceeds in Replacement QSBS Under Section 1045.
Section 1045 provides flexibility when a partnership sells QSBS. Either the partnership or individual partners can reinvest the sales proceeds. But there is a fair amount of complexity that accompanies this flexibility, making it important for the parties involved to work with knowledgeable tax advisors.
6. Section 1045 Permits Sellers of QSBS to Reinvest Their Sales Proceeds Through Partnerships.
Section 1045's regulations open the door for sellers of QSBS to reinvest the sales proceeds through a partnership (i.e., contributing QSBS sales proceeds to a partnership). If a seller of QSBS decides to contribute the sales proceeds to a partnership, those funds must be reinvested by the partnership into replacement QSBS during the investor's 60-day window under Section 1045.
7. Be Sure to Fully Document Satisfaction of Section 1202's (and Section 1045's) Eligibility Requirements.
Stockholders who roll QSBS sales proceeds over under Section 1045 into replacement QSBS should fully document satisfaction of Section 1202's eligibility requirements for both their original and replacement QSBS investments. See the article Dissecting Section 1202's 'Active Business' and 'Qualified Trade or Business' Qualification Requirements for more detailed information. If a seller of original QSBS decides to organize a new C corporation to issue the replacement QSBS, the main challenge will be documenting compliance with all of Section 1202's requirements regarding undertaking start-up and R&D activities (whether the rollover of proceeds involves starting a new qualified small business from scratch or purchasing one.) With respect to satisfying Section 1045's requirements, the election to take advantage of that provision must be properly made on the stockholder's tax return, and reinvestment of the QSBS sales proceeds within the allowed 60-day window should be fully documented.
In spite of the potential for extraordinary tax savings, many experienced tax advisors are not familiar with Section 1202 and Section 1045 planning. Venture capitalists, founders and investors who want to learn more about Section 1202 and Section 1045 planning opportunities are directed to several articles on the Frost Brown Todd website:
If you want an in-depth discussion of Section 1045, see the article Advanced Section 1045 Planning.
Other Section 1202 Articles Include:
Section 1202 Qualification Checklist and Planning Pointers
A Roadmap for Obtaining (and not Losing) the Benefits of Section 1202 Stock
Maximizing the Section 1202 Gain Exclusion Amount
Dissecting 1202's Active Business and Qualified Trade or Business Qualification Requirements
Recapitalizations Involving Qualified Small Business Stock
The 21% Corporate Rate Breathes New Life into IRC § 1202
1 There are exceptions to the general rule when the stockholder receives QSBS as a gift, as a distribution from a partnership, upon the death of the original holder, or in connection with the receipt of replacement QSBS in connection with a tax-free exchange or reorganization.
Scott W. Dolson
United States Tax Sales Taxes: VAT, GST Tax Authorities
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Are you looking for a static caravan for sale in North Wales?
North Wales is a beautiful place to own a static caravan in the UK. It is widely regarded as one of the most popular destinations in the UK due to having stunning beaches, warm climate and friendly people.
Read on to discover why searching for a static caravan for sale in North Wales is an excellent choice.
A static caravan is a popular type of holiday home that remains permanently on a particular position on a holiday park. Static caravans are fantastic as they have everything you need for a holiday base for the family.
Holiday parks in North Wales will be well presented, with plenty of facilities and activities for everyone to enjoy. Wales, and in particular North Wales, has been a popular destination for holidaymakers for decades. You will be amazed by the stunning scenery of mountain ranges as well as an idyllic coastline. Choose Wales to buy a static caravan and you will find plenty of activities to entertain the whole family. Filling the days couldn't be easier here, with attractions like Zip World and Surf Snowdonia for all to enjoy.
North Wales is an area of outstanding natural beauty with stunning scenery. In particular the Snowdonia National Park sets the region apart from others in the UK. Here visitors are able to access the historical Snowdon Mountain Railway which climbs to the summit of Wales's highest mountain, Mount Snowdon. From here you can marvel at stunning views across the sea to Ireland.
Did you know? People from North Wales are sometimes referred to as 'gogs', a term that derives from the Welsh word for North.
The Welsh have a reputation for being friendly and welcoming. They are proud of their history and ensure that all that visit their country feels at home. There is a proud culture in Wales which can be found in their music, customs and language. Owning your own static caravan in this region will mean you can really soak up the atmosphere and learn about another culture.
Finding a static caravan for sale in North Wales and buying will mean you will be able to visit more often. One of the benefits of visiting this region more often is the fantastic food. The food in Wales is diverse, but there are a number of traditional dishes visitors should try. Bara Brith is a tea loaf made with dried fruit and spices and is often enjoyed as part of an afternoon tea. Another popular delicacy is Welsh Rarebit, a take on cheese on toast with ale, mustard, cayenne pepper and Worchester sauce.
If you're considering purchasing your own static caravan. North Wales, with its stunning locations is a must for you to consider. It's easily accessible from all corners of the UK, meaning visiting for a long weekend couldn't be simpler. Due to the nature of static caravan holidays, you will find yourself outdoors more often, therefore the weather is an important factor. Luckily the coastal areas of North Wales experience plenty of sunshine in the summer months, with scorching highs of 25°C.
Popular coastal areas in North Wales include Barmouth, Fairbourne and Shell Island, all of which have their own unique appeal. Here you will find stunning places to own your own static caravan with great weather and friendly locals. It is easy to see why North Wales is such a popular choice for people looking to buy a static caravan.
Are you looking for a static caravan for sale in North Wales? CLICK HERE to few a selection of parks we are working with and enquire today.
When looking to buy a static caravan, it is important that you weigh up the pro's and con's of buying a static caravan. If bought for the right reasons you will be sure to find a great joy in owning a static caravan. For most venturing into the world of holiday home ownership is an enjoyable experience. You get to focus on the important things in life such as family, friends and leisure experiences.
Many holidaymakers dream of one day owning their very own home away from home. Buying a static caravan is the obvious choice where that this dream can be realised. Returning to a location that you love, to enjoy a holiday whenever you please is a great luxury. That said, buying a static caravan should always be considered carefully by those keen to take the plunge into ownership.
Here we have put together a list of pros and cons to help you make your decision a much easier one.
For many people, one massive draw when buying a static caravan is the opportunity to go on holiday whenever they choose. Owning your own caravan or lodge on park gives you the flexibility to arrive and depart at a time that suits you. There will be no need to book ahead or check in which can appeal to many people.
Booking accommodation online can be a roulette. Most of the time you will fall lucky and receive a nice standard of accommodation. Other times you may get let down or something may not be quite as described. Who enjoys spending hours browsing for the best rates in the most desirable locations only to feel let down when they are booked. Knowing where you are going and where you are staying can give you more piece of mind.
While the communities that we build at home are important, sometimes we need to look further afield and consider where else we can become part of something. The great thing about holiday home ownership parks is you are surrounded with like minded people which enjoy getting away and enjoying the good things in life. You are able to choose your park based on your interests and circumstances; for example, if you have children, find a family-friendly holiday park that your children will be able to make friends on. Building lasting relationships on a holiday park is great for sociable people and could present a better option than visiting a different resort or park every year.
Have you ever considered letting out your static caravan to other holidaymakers while you aren't there? This can be a great source of income, especially during the peak months, such as the summer holidays. Many holiday parks have fantastic letting schemes where they can take care of all aspects of the letting for you. This will work well as you can enjoy many holidays whilst making it help towards runnings costs. There are cons associated with letting out your holiday home which you need to be aware of and ensure you have prepared for.
It may be let when you want to use – Rent out your holiday home in blocks and plan your time in first.
The holiday home will suffer wear & tear – With more use comes more wear & tear however the income you will make will outweigh the expense of replacing the carpet eventually or repair works.
Whilst it is true that for most people buying a static caravan is reported to be one of the best things they have ever done. There can be a few drawbacks that you may want to consider before making your final choice.
Are you the kind of person that struggles to stay in the same place? If so, you may struggle with the concept of visiting the same location time and time again. While it can be comforting to grow familiar with your surroundings, some may find this monotonous over time. Having said that, most parks are situated in stunning surroundings with national parks with plenty of trails and walks nearby. This means there is plenty of opportunity to get out and about the area which will give variety to your experience.
Just as you need to invest in your home to maintain it, you will need to do the same with a static caravan. You will need to allow for general upkeep and ensure that your static caravan is safe to use. While it can give many a sense of pride of ownership and accomplishment. For others, maintaining their own home as well as a static caravan can be a challenge. Parks usually provide services to help maintain your caravan including gas and electric servicing. These services can be convenient and necessary however you will need to allow for this outlay.
When buying a static caravan you may want to consider the process if you ever need to sell. Your static caravan is a valuable asset and at some point you may have a change of life circumstance which forces you to consider selling. Many Parks will help you will this process and offer a price to buy it back from you. Ensure you know what the company policy if so you can plan ahead. Here at Parklink we have a dedicated page where you can advertise your private caravan for sale. CLICK HERE to find out more.
While the initial investment in a static caravan represent a large purchase. It's important to recognise the long-term enjoyment you will get from owning your own – Memorable family holidays, on your own terms, in a place that you love can mean a lot. If you value freedom, relaxation and family time then holiday home ownership will benefit you.
Now you have considered buying a static caravan pros and cons perhaps you would like to discover more and request further information. Parklink is the 'go to' place for holiday home ownership and we would like to help you get the information you need.
Are you interested in buying a static caravan? We have some fantastic private sales on our books which can offer you massive savings! CLICK HERE to view now.
Perhaps you would like to view holiday parks where you can own a static caravan on? CLICK HERE to view our selection of Parks in the UK you can own a holiday home on.
Thank you for reading our article. We would love to hear any further pros and cons you think would be worth sharing with people. CLICK HERE to message us now.


text:
Command & Conquer: Generals
by jetblack | Mar 1, 2003 | LJ Archive | 1 comment
I've been a fan of the Command & Conquer series of games, ever since the original published in the mid-90s for MS-DOS. I remember that we all went out a bought copies, and then null modem cables so we could set up head-to-head matches in the special accounts lab, where my group also work out of during the graveyard shift. Now and I, since we both left the hellhole known as Acer, have sort of continued the tradition of real-time strategy games, though it's not been limited to C&C. We both played Red Alert and loved it, but when it came to Tiberian Sun, I think both of us were pretty disappointed with the game. When Red Alert 2 came out, I remember the phone call and invitation to hunker down into his hovel underneath the house to watch him play the game, and I was pretty much sold as that point. I went out and bought it, and then the expansion pack. The only problem with C&C:RA2 was the stupid Westwood TCP drivers. Anytime I tried to play that game and used the internet tools that came with it to hook up with and play over the net, it would utterly destroy my TCP stack and I would have to reboot in order to get net connection back. It sucked royally.
Now, I knew Generals was coming out, but I guess my attention toward the game sort of faltered, because I forgot the street date for the game. Fate intervened apparently, because when I went over to Gamestop to see my roommate at his place of work, he mentioned that Generals was released that day and, of course, I snatched up a copy immediately. I played that game for about 4 hours, only in skirmish mode. I always start playing RTS games in the skirmish mode, because you're not timed and there's no objective but to defeat your enemy. Only then can I get a real feel for the building structures, unit heirarchies, what's required to reach a certain unit that will rule all. The neat thing about Generals is that there is no uber-unit, that I'm aware of. In fact, if you don't work your units in some kind of harmony, there's just no way you can win with only building a mess of certain units.
I'm having a lot of fun, but the minimum requirements are insane. On spike, I have to reboot every time I play the damn game. Yikes, this game is a resource beast…
inetmonkey	on March 3, 2003 at 06:33
What?!? No Gonzalo squad? How lame!


Macular holes can cause a distortion and loss of central vision, interfering with daily life.
Macular holes are tears on the macula, which cause a defect or dark spot in the central vision, resulting in distortion and a loss of central vision.
The macular is the part of the retina used for visual task work such as driving and reading. A macular hole can develop and cause distortion and a loss of central vision making day to day activities/tasks problematic.
Macular holes tend to develop with age, usually appearing in people in their 60's and 70's and the occurrence is more prevalent in females.
Surgery is required to treat a macular hole and special follow-up care is required. Auckland Eye have enormous experience in dealing with macular hole surgery and will be on hand to support you through the whole process.
For more information on macular holes and treatment, please contact our friendly specialist team.
In order to see clearly, light from an object has to be focused by the optical elements of the eye onto the retina. The retina is a thin layer, about the thickness of a piece of tissue paper, which is next to the inside wall of the eye.
There are certain parts of the retina that perform different visual tasks. For example the retina towards the front of the eye is best used for detecting objects in the dark. The macula is another small part of the eye which we use for visual tasks such as reading, driving and watching TV. A hole in this part of the retina is called a macular hole.
How do macular holes develop?
It is not yet known how holes develop in the macula. Some experts believe that the thin membrane lying on the surface of the retina can develop abnormal connections with the macula and a small tear may occur. If this tear enlarges, a full macular hole can develop.
What are the risk factors to developing macular holes?
Macular holes are more common in people in their sixties and seventies, although they can occur in other age groups. Women are more susceptible to developing macular holes than men. People with macular holes in one eye also have a greater risk of developing a hole in their other eye.
Some reports have suggested there is a higher incidence of macular holes in women who have had a hysterectomy and who are on hormone replacement therapy. However there are no reports suggesting discontinuing hormone replacement decreases the risks of a hole development, and most authorities do not advise stopping therapy.
During the mid 1990s micro-surgical techniques were developed which have proved successful in some patients with macular holes.
Macular hole surgery involves removal of the vitreous, a procedure known as a vitrectomy . The vitreous is a thick, transparent substance that fills the centre of the eye. This enables the surgeon to access and remove the membranes holding the macular hole open. Once the traction is released the hole can be closed.
The success of the surgery is dependent on the hole remaining 'sealed'. A gas bubble is placed in the eye to help repair and assist in keeping the macular hole closed.
Click here to view a short surgical video of a vitrectomy.
Click here to view a short surgical video of a vitrectomy with an epi-retinal membrane peel.
Click here to see a surgical video of a macular hole operation.
Macular hole surgery can be performed under local or general anaesthesia. The eye may a feel a little gritty and uncomfortable for a period following surgery but pain is rare. After surgery the patient must lie face down for a period of 10 days. Your surgeon will discuss the necessary posture requirements and success rates in further detail.


text:
IIM SHILLONG
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The IIM Shillong classrooms are designed to become a stage for intellectual and interdisciplinary collaboration, creativity and critical thinking. A strong technological infrastructure, instructional technologies, seating architecture facilitate a culture of innovation, experimentation and intellectual freedom aimed at grooming responsible managers for tomorrow.
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Spread over an area of more than 10000 sq. feet, the library in the IIM Shillong campus provides ample quiet study space to its users. With its contemporary design, the reading room overlooks the scenic hills covered in pine trees, providing for an inviting and tranquil open space to its readers.
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The Library subscribes to both online and physical newspapers and magazines whilst the scholarly e-Collection is accessible from any networked computer within the campus via E-Library Portal. The library houses a collection of more than 15000 physical books, reports, dissertation and thesis which are searchable on the OPAC. The library services include tools like Turnitin plagiarism checker, E-resources search (databases, articles, reports etc.), and remote access (off campus facility). The library hosts the finance lab powered by Bloomberg wherein real time financial data can be accessed. To facilitate resource sharing, it participates in different consortia like the IIM consortium and e-Shodhsindhu. It is a member of different resource sharing network like DELNET, INFLIBNET etc. that provides access to a collection of more than 5000 e-journals and 1 lakh plus dissertation and thesis. The RFID-equipped self-service kiosks facilitate automated check-in, check-out and renewals.
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Last modified: January 10, 2023 at 7:07 am
Shri. Maneesh Jaikrishna
Maneesh Jaikrishna is currently serving as Regional Vice President for Middle East, APAC and Africa at Embross. Prior to this, he had had an illustrious 21 years career at SITA as the Vice President & General Manager for Indian Subcontinent, Dubai, Eastern & Southern Africa. He brings with him an extensive leadership experience in building organizations from ground up, business transformation and leading multi-functional teams in medium sized and large organizations across 30+ countries across ME, APAC, Indian Subcontinent & Africa while growing profitable businesses in the global Travel & Transport Industry. He has been instrumental in enabling win-win business outcomes through application of advance technology led IT systems and services to improve the travel experience, safety, security and operational efficiency for his airport, airline, government and other industry stakeholders.
Recipient of several awards, he had been nominated to SITA Board for 16 years and currently is an ExCo member in Embross. He has authored several articles, white papers as the media spokesperson which have been covered extensively in leading national and international publications. He had also been nominated to the Sectoral Innovation Council of the Ministry of Civil Aviation and as a member in the FICCI Civil Aviation Committee.
He holds a first class first B.E. (Hons.) degree in Electronics & Telecommunications of Mumbai University, and also an Executive Master of Business Administration degree from IMD Business School, Switzerland.
Regional Vice President for Middle East,
APAC and Africa at Embross
Post Graduate Programme for Working Executives
Degree: MBA for Working Executives (MBAWE)
Duration: Two-Year Program Live Classes held over Electronic Mode
Current Company Name*
Job Title.*
Work Experience(in months)*
Dr. D P Goyal
Dr. D P Goyal, Director, IIM Shillong, is an internationally acclaimed academician and researcher. He carries over thirty-five years of rich experience in teaching, research and various leadership roles in few of India's finest institutions including MDI Gurgaon, IMT Ghaziabad and Thapar Institute of Engineering & Technology, Patiala. He is also a visiting Professor at Aarhus University, Denmark. Prof Goyal has already supervised fifteen PhD research scholars; published over 60 research papers and has been principal investigator of several sponsored research projects. He has more than a dozen books to his credit which includes three highly popular text books in Information Systems area. He has also been the editor of a couple of research journals and is on the Editorial Board of several national and international journals.
Prof Goyal has been on the expert/assessment/selection committees of various National bodies and is also on the Board of Governor/Governing Council; Academic Advisory Board; Academic Council; Board of Studies of a large number of business schools and universities.
Shri. Ashutosh Dikshit
Shri. Ashutosh Dikshit has over 16 years of professional experience in the roles of Presales, Innovation Consulting, Marketing and Program Management. During his career, he has worked across organizations such as Deloitte, IBM, Wipro Technologies, Birlasoft and University College London. In his current role, Ashutosh leads the CxO and Executive Briefing Program for Europe, Middle East and Africa (EMEA) at Amazon Web Services (AWS) and is based in London. He is an alumnus of IIM Shillong (PGP 2008-10) and is one of the winners of the prestigious Global Peter Drucker Challenge (2015).
CxO Advocacy and Executive Marketing - Senior Manager EMEA,
Amazon Web Services & Alumnus, IIMS
Dr. Paula Sengupta
Dr. Paula Sengupta is an artist, academic and curator resident in Kolkata. She graduated in Painting from the College of Art, New Delhi, followed by an MFA and PhD in Printmaking from Kala Bhavana, Santiniketan. She is currently Professor at the Department of Printmaking at Rabindra Bharati University, Kolkata.
She is author of The Printed Picture: Four Centuries of Indian Printmaking published by DAG, New Delhi and Foreign & Indigenous Influences in Indian Printmaking with LAP Lambert Academic Publishing, Saarbrucken, Germany.
Her curatorial projects include a soul (un)gendered: Anupam Sud – A Retrospective for DAG MODERN & KNMA, Delhi in 2019-20; Ghare Baire at the Old Currency Building, Kolkata for DAG MODERN and the Archaeological Survey of India in 2019; Popular Prints and the Freedom Struggle at the Drishyakala Museum, Red Fort, Delhi for DAG MODERN and the Archaeological Survey of India in 2019; the landmark exhibition Trajectories: 19th-21st Century Printmaking from India and Pakistan for the Sharjah Art Museum, Sharjah, UAE in 2014; and six editions of The Printed Picture: Four Centuries of Indian Printmaking for DAG MODERN, India from 2012-18.
Prof. Paula Sengupta
Ravindra Bharati University
Shri. Atul Chandrakant Kulkarni
Shri Atul Chandrakant Kulkarni is an Independent Management and Strategy Consultant in Infrastructure domain with special focus on Maritime Industry.
He has been advising various domestic and international clients on Feasibility Study, Project Master Plan, Business Plan, Operations and Strategy. He serves as Director on the boards of Eurasia Special Technologies Pvt Ltd. (Defense Equipment), Varti Agro Pvt Ltd. (Exports of Fresh Fruits), 3.Yuva Vikas Society (Skill Development), etc. He is also associated in the advisory committees and governing councils/boards of SNDT University, Mumbai, Adi Sankara Group of Institutions, Kerala, National Institute of Industrial Engineering (NITIE), Mumbai, among others.
He had earlier been associated in various roles including 'C Level' position with Chowgule Ports & Infrastructure Pvt. Ltd., V R Marine Services Pte Ltd, Singapore, Indian Ports Association, Gas Authority of India Limited, Deloitte Touche Tohmatsu India Pvt. Ltd, Ministry of Shipping, GoI, Camlin Ltd. and many others over his 3-decade professional career.
He is also Chairman of a Public Charitable Trust SEIL (Students' Experience in Inter-state Living) focusing on National Integration.
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Shri. Shishir Kumar Bajoria
Shri Shishir Bajoria is a well-known Industrialist and the head of S K Bajoria Group – manufacturing ceramics for the steel industry in India, UK, USA, Germany, China. His businesses also include insurance services involving health and travel insurance administration, claim settlement, insurance and re-insurance broking; as well as an Art Gallery.
He has been the President of the Indian Chamber of Commerce- Kolkata, Honorary Vice Counsel for Denmark in Eastern India and has also been a Director of the State Industrial Development Corporations of Orissa (IPICOL) and West Bengal (WBIDC). He has been Knighted by the Governments of Denmark in 1998 and Italy in 2006.
Chairman Board of Governors, IIM-S
Head of S K Bajoria Group


text:
Otto Lüdecke (* 28. Januar 1909 in Hamburg; † 18. März 1990 ebenda) war ein deutscher Fußballspieler und -trainer. Der Mittelfeld- und Abwehrspieler hat mit seinem Heimatverein Eimsbütteler TV in der Gauliga Nordmark in den Jahren 1934, 1935, 1936 und 1940 die Meisterschaft gewonnen und mit dem ETV in den nachfolgenden Endrunden um die deutsche Fußballmeisterschaft 24 Spiele (1 Tor) absolviert. Als Kriegsgastspieler gewann er 1940/41 mit dem LSV Stettin die Gaumeisterschaft in Pommern und trat mit Stettin in weiteren vier Endrundenspielen an.

Spielerkarriere

Vereine
Lüdecke spielte von 1929 bis 1949 für die erste Mannschaft des ETV, u. a. in der Gauliga Nordmark, unterbrochen durch eine Zeit als Gastspieler in der Gauliga Pommern, zwei von zunächst 16, später auf 23 aufgestockten Gauligen zur Zeit des Nationalsozialismus als einheitlich höchste Spielklasse im Deutschen Reich. Von 1940 bis 1943 war er Gast beim LSV Stettin. Von 1934 bis 1936 feierte der spätere Lehrer drei Meisterschaften in Folge in der Gauliga Nordmark und 1938 und 1939 jeweils die Vizemeisterschaft. Er gehörte der ETV-Elf als Mittelläufer an, die am 2. Dezember 1934 einen 8:3-Erfolg gegen den Hamburger SV erzielen konnte und laut dem Magazin "Fußball" dabei "die Ränge vor Begeisterung rasten."

Das erste seiner 24 Endrundenspiele für Eimsbüttel bestritt der zwei Jahrzehnte zuverlässige Akteur am 6. April 1934 auf dem Victoria-Platz bei einem 5:1-Erfolg gegen den VfL Benrath. Er dirigierte dabei als Mittelläufer die Abwehr und hatte es insbesondere mit dem Benrather Nationalstürmer Karl Hohmann zu tun gehabt. Erfolgreich schnitt Lüdecke mit dem ETV in den Endrunden nicht ab, aber gegen den deutschen Meister der Jahre 1934 und 1935, den FC Schalke 04, gelang jeweils ein Heimerfolg. Am 29. April drehte die Mannschaft um Lüdecke einen 0:2-Halbzeitrückstand zu einem 3:2-Sieg und auch am 26. Mai 1935 setzte sich der Nordmeister mit einem 2:1 auf dem Victoria-Platz gegen die "Knappen-Elf" aus Schalke durch.

Durch einen Meisterschaftsgewinn mit 35:1-Punkten gelang in der Serie 1947/48 in der Alster-Staffel und den nachfolgenden Aufstiegsspielen gegen Bremerhaven 93, Göttingen 05, Itzehoer SV, Altona 93 und Teutonia Uelzen der Einzug in die erstklassige Fußball-Oberliga Nord. In der Saison 1948/49 absolvierte er 16 Spiele in Folge, ehe ihn eine Operation zur Aufgabe zwang. Der Senior war auch beim 2:1-Erfolg am 26. September 1948 gegen den Hamburger SV im Einsatz gewesen.

1949 wechselte er beim Eimsbütteler TV auf den Trainerstuhl und wirkte gegen Saisonende noch zweimal selbst mit.

Auswahlmannschaft
Lüdecke wurde jeweils in die Gauauswahlmannschaft Nordmark und Pommern berufen, zum Nationalspieler reicht es jedoch nicht.
Die erste Berufung in die Gauauswahl Nordmark erhielt er im Wettbewerb um den Bundespokal 1935. Am 3. Februar 1935 lief er als Mittelläufer in Hamburg beim Spiel gegen die Auswahl von Sachsen auf. Beim 4:2-Erfolg spielte er an der Seite seiner ETV-Vereinskollegen Karl Böhlke, Erwin Stührk, Hans Rohde, Wilhelm Ahlers, Otto Rohwedder und Herbert Panse. Mit der Gauauswahl Nordmark gewann er 1937/38 nach Erfolgen gegen die Gauauswahlmannschaften Pommern und Niederrhein, im Halbfinale gegen die Gauauswahlmannschaft Baden und im Endspiel gegen die Gauauswahlmannschaft Südwest am 6. März 1938 in Erfurt mit 3:1 Toren den Reichsbundpokal. Zu der siegreichen Mannschaft gehörten neben Otto Lüdecke die HSV-Spieler Walter Warning, Richard Dörfel, Erwin Reinhardt, Werner Höffmann, Rudolf Noack und Gustav Carstens sowie die Eimsbütteler Hans Rohde, Wilhelm Ahlers und Herbert Panse und der noch beim SC Victoria Hamburg spielende Erwin Seeler.

Er nahm auch mit der Nordmark-Auswahl am deutschen Turn- und Sportfest 1938 in Breslau teil und stand auch am 3. Dezember 1939 in Hamburg in der Verteidigung bei einer 3:6-Niederlage gegen Sachsen. Als Gastspieler von Stettin nahm er 1940/41 und 1941/42 am Reichsbundpokal für Pommern bei den Spielen gegen Mitteldeutschland und Sachsen teil. Insgesamt wird er mit 10 Gau-Auswahl-Wettbewerbsspielen in der Statistik geführt.

Stationen
 1929 bis 1940: Eimsbütteler TV
 1940 bis 1943: LSV Stettin
 1943 bis 1945: nicht bei Eintracht Braunschweig (der dort hieß Lüddecke)
 1945 bis 1950: Eimsbütteler TV (1949/50 als Trainer)

Erfolge
 Reichsbundpokal-Sieger 1938

Trainerkarriere
Für mehrere Spielzeiten (ab 1950 über 1951/52 und 1953/54) trainierte er den SC Victoria Hamburg. 1956 übernahm er diese Mannschaft erneut.

Stationen
 1950 bis 1954: SC Victoria Hamburg (Trainer)
 ab 1956: SC Victoria Hamburg (Trainer)

Sonstiges
Lüdecke war von Beruf Lehrer. Im Alter von 81 Jahren verstarb er in seiner Geburtsstadt und wurde auf dem dortigen Friedhof Ohlsdorf neben seiner Frau Gretel, geb. Turowski (1911–1979), beigesetzt. Die Grabstätte liegt im Planquadrat W 15, nordwestlich von Kapelle 2.

Walter Jens, als Junge ein Anhänger des ETV, verfasste den Artikel Vorbei die Eimsbütteler Tage und hat darin seine Erinnerungen an die ETV-Glanzzeit in Worte gefasst:

Literatur
 Folke Havekost: ETV Hamburg. 100 Jahre Fußball in Eimsbüttel. Verlag Die Werkstatt. Göttingen 2006. ISBN 978-3-89533-529-7.
 Hardy Grüne, Lorenz Knieriem: Spielerlexikon 1890 bis 1963. Agon Sportverlag. Kassel 2006. ISBN 978-3-89784-148-2. S. 240.

Weblinks

 Eintrag auf pruess-oberliga.de

Einzelnachweise

Fußballspieler (Eimsbütteler TV)
Fußballspieler (Eintracht Braunschweig)
Fußballspieler (LSV Stettin)
Fußballtrainer (Deutschland)
Geboren 1909
Gestorben 1990
Deutscher
Mann

redpajama_set_name: RedPajamaWikipedia


text:
Q: Clicking on the button selects everything, instead of selecting only one Angular 13 So whenever i click on any 'Follower' button it just selects everything there is available instead of just selecting only one... How can i fix this?
Example:

It doesn't matter which button i click, it just selects everything available
Here's the code:
follower service
export class FollowerService {

  constructor(private http: HttpClient) { }

  public url: string = environment.apiBaseUrl;

  followUser(userId: number, follower: Follower){
    return this.http.post<Follower>(`${this.url}/follow/user/${userId}`,follower);
  }
  unfollowUser(userId: number) {
    return this.http.delete<Follower>(`${this.url}/unfollow/user/${userId}`);
  }
  getUserFollowers(userId: number) {
    return this.http.get<FollowerModel[]>(`${this.url}/user/${userId}/followers`);
  }
  getUserFollowee(userId: number) {
    return this.http.get<FolloweeModel[]>(`${this.url}/user/${userId}/followee`);
  }
}

follower component
export class FollowersComponent implements OnInit {

  constructor(private userService: UserService, private followerService: FollowerService) { }

  users: User[];
  follower: Follower;
  isFollowed: boolean;
  ngOnInit(): void {
    this.userService.getUsers().subscribe(response => {
      this.users = response;
    });
  }

  followUser(userId: number){
    this.followerService.followUser(userId, this.follower).subscribe(response => {
      this.follower = response;
      this.isFollowed = true;
    });
  }

  unfollowUser(userId: number){
    this.followerService.unfollowUser(userId).subscribe(response => {
      this.isFollowed = false;
    });
  }
}

follower entity
export class Follower {
    id: number;
    followee: User;
    follower: User;
}

follower template
<app-toolbar></app-toolbar>

        @{{user.username}}

            <button mat-raised-button color="primary" (click)="followUser(user.id)">Follow</button>

            <button mat-flat-button color="warn" (click)="unfollowUser(user.id)">Unfollow</button>

A: It is due to your conditions *ngIf="!isFollowed" and *ngIf="isFollowed".
And you set isFollowed to true in followUser method. So, all the user will be selected.
You have do be more specfic, and make something like *ngIf="!user.isFollowed".

redpajama_set_name: RedPajamaStackExchange


TalkTalk has renewed its agreement with Sky to provide its customers with ongoing access to its basic and premium channels.
The latest multi-year agreement covers entertainment channels Sky 1, Sky Arts and Sky Living as well as premium channels Sky Sports and Sky Cinema. Pay-per-view service Sky Box Office is also included, but there's no mention of Sky Atlantic.
TalkTalk launched its TV offering, which is powered by YouView, in 2012 and currently has around 1.4 million customers. The service is a hybrid of terrestrially delivered channels via the Freeview signal and pay TV channels delivered via the internet. It is currently the only YouView based service that includes any of Sky's main entertainment channels.


text:
February 10, 2015 2014-2015 News Releases
FOR IMMEDIATE RELEASE: FEBRUARY 10, 2015
The 2015 KHSAA State Bowling Championships visit Collins Eastland in Lexington this week (Feb. 12-13), with the singles championship slated for Thursday and the team competition set for Friday. The team championship matches will be streamed live at KHSAA.tv, with the girls' team finals scheduled for 12:15 p.m., followed by the boys' team championship at 5:15 p.m.
Thursday's boys' and girls' singles competition begins with qualifying games at 10:10 a.m., as the field is trimmed to the top eight individuals. The top eight will roll three additional games, with the top four boys' and girls' singles advancing to the step ladder bracket, which will continue through its completion. Awards for the singles competition are tentatively scheduled for 2:30 p.m.
The girls' team championship opens Friday's action, with team introductions slated for 7:30 a.m. and qualifying games starting at 7:50 a.m. Following two qualifying games, each team will be seeded in a 16-team bracket with the state champion determined through baker matches. Team introductions for the boys' championship get underway at 1:15 p.m., with qualifying games scheduled for a 1:35 p.m. start time.
Lane Assignments for Thursday's singles competition can be found at:
http://khsaa.org/bowling/2015/2015singleslaneassignments.pdf
Lane Assignments for Friday's team competition are available at:
http://khsaa.org/bowling/2015/2015teamlaneassignments.pdf
The official championship program can be viewed here:
http://khsaa.org/Publications/Programs/20142015/Bowling/issue1/index.html
Championship results will be posted to KHSAA.org as they become available.


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Review of the U.S. Department of Agriculture's Animal and Plant Health Inspection Service Response to Petitions to Reclassify the Light Brown Apple Moth as a Non-Actionable Pest: A Letter Report (2009)
Chapter: Front Matter
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Suggested Citation:"Front Matter." National Research Council. 2009. Review of the U.S. Department of Agriculture's Animal and Plant Health Inspection Service Response to Petitions to Reclassify the Light Brown Apple Moth as a Non-Actionable Pest: A Letter Report. Washington, DC: The National Academies Press. doi: 10.17226/12762.
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Review of the U.S. Department of Agriculture's Animal and Plant Health Inspection Service Response to Petitions to Reclassify the Light Brown Apple Moth as a Non-Actionable Pest A Letter Report   Committee for the Review of the U.S. Department of Agriculture's Animal and Plant Health Inspection Service Response to Petitions to Reclassify the Light Brown Apple Moth as a Non-Actionable Pest Board on Agriculture and Natural Resources Division on Earth and Life Studies      Â
  THE NATIONAL ACADEMIES PRESS 500 Fifth Street, N.W. Washington, DC 20001 NOTICE: The project that is the subject of this report was approved by the Governing Board of the National Research Council, whose members are drawn from the councils of the National Academy of Sciences, the National Academy of Engineering, and the Institute of Medicine. The members of the committee responsible for the report were chosen for their special competences and with regard for appropriate balance. This study was supported by a grant from U.S. Department of Agriculture, Animal and Plant Health Inspection Service under Grant No. 09-8100-1363-GR. Any opinions, findings, conclusions, or recommendations expressed in this publication are those of the author(s) and do not necessarily reflect the views of the organizations or agencies that provided support for the project. The report is available online from the National Academies Press at http://www.nap.edu. Copyright 2009 by the National Academy of Sciences. All rights reserved. Printed in the United States of America
 The National Academy of Sciences is a private, nonprofit, self-perpetuating society of distinguished scholars engaged in scientific and engineering research, dedicated to the furtherance of science and technology and to their use for the general welfare. Upon the authority of the charter granted to it by the Congress in 1863, the Academy has a mandate that requires it to advise the federal government on scientific and technical matters. Dr. Ralph J. Cicerone is president of the National Academy of Sciences. The National Academy of Engineering was established in 1964, under the charter of the National Academy of Sciences, as a parallel organization of outstanding engineers. It is autonomous in its administration and in the selection of its members, sharing with the National Academy of Sciences the responsibility for advising the federal government. The National Academy of Engineering also sponsors engineering programs aimed at meeting national needs, encourages education and research, and recognizes the superior achievements of engineers. Dr. Charles M. Vest is president of the National Academy of Engineering. The Institute of Medicine was established in 1970 by the National Academy of Sciences to secure the services of eminent members of appropriate professions in the examination of policy matters pertaining to the health of the public. The Institute acts under the responsibility given to the National Academy of Sciences by its congressional charter to be an adviser to the federal government and, upon its own initiative, to identify issues of medical care, research, and education. Dr. Harvey V. Fineberg is president of the Institute of Medicine. The National Research Council was organized by the National Academy of Sciences in 1916 to associate the broad community of science and technology with the Academy's purposes of furthering knowledge and advising the federal government. Functioning in accordance with general policies determined by the Academy, the Council has become the principal operating agency of both the National Academy of Sciences and the National Academy of Engineering in providing services to the government, the public, and the scientific and engineering communities. The Council is administered jointly by both Academies and the Institute of Medicine. Dr. Ralph J. Cicerone and Dr. Charles M. Vest are chair and vice chair, respectively, of the National Research Council.  www.national-academies.org Â
 COMMITTEE FOR THE REVIEW OF THE U.S. DEPARTMENT OF AGRICULTURE'S ANIMAL AND PLANT HEALTH INSPECTION SERVICE RESPONSE TO PETITIONS TO RECLASSIFY THE LIGHT BROWN APPLE MOTH AS A NON-ACTIONABLE PEST MAY R. BERENBAUM (Chair), University of Illinois, Urbana-Champaign THOMAS E. BUNDY, Office of General Counsel, U.S. Department of Agriculture, Washington, DC (retired) SEAN B. CASH, University of Wisconsin, Madison; University of Alberta, Canada (on leave) RACHAEL E. GOODHUE, University of California, Davis VINCENT P. JONES, Tree Fruit Research and Extension Center, Washington State University, Wenatchee NICHOLAS J. MILLS, University of California, Berkeley L. JOE MOFFITT, University of Massachusetts, Amherst JERRY A. POWELL, University of California, Berkeley (emeritus) DANIEL S. SIMBERLOFF, University of Tennessee, Knoxville ROBERT C. VENETTE, U.S. Forest Service, St. Paul, Minnesota Staff ROBIN A. SCHOEN, Director KARA N. LANEY, Associate Program Officer KAMWETI MUTU, Research Associate KAREN L. IMHOF, Administrative Assistant NORMAN GROSSBLATT, Senior Editor vÂ
  BOARD ON AGRICULTURE AND NATURAL RESOURCES NORMAN R. SCOTT, Chair, Cornell University, Ithaca, New York PEGGY F. BARLETT, Emory University, Atlanta, Georgia ROGER N. BEACHY, Donald Danforth Plant Science Center, St. Louis, Missouri HAROLD L. BERGMANN, University of Wyoming, Laramie RICHARD A. DIXON, Samuel Roberts Noble Foundation, Ardmore, Oklahoma DANIEL M. DOOLEY, University of California, Oakland JOAN H. EISEMANN, North Carolina State University, Raleigh GARY F. HARTNELL, Monsanto Company, St. Louis, Missouri GENE HUGOSON, Minnesota Department of Agriculture, St. Paul KIRK C. KLASING, University of California, Davis VICTOR L. LECHTENBERG, Purdue University, West Lafayette, Indiana PHILIP E. NELSON, Purdue University, West Lafayette, Indiana ROBERT PAARLBERG, Wellesley College, Watertown, Massachusetts KEITH PITTS, Marrone Bio Innovations, Davis, California CHARLES W. RICE, Kansas State University, Manhattan HAL SALWASSER, Oregon State University, Corvallis PEDRO A. SANCHEZ, The Earth Institute, Columbia University, Palisades, New York ROGER A. SEDJO, Resources for the Future, Washington, DC KATHLEEN SEGERSON, University of Connecticut, Storrs MERCEDES VAZQUEZ‐AÑON, Novus International, Inc., St. Charles, Missouri Staff ROBIN A. SCHOEN, Director KAREN L. IMHOF, Administrative Assistant AUSTIN J. LEWIS, Senior Program Officer EVONNE P.Y. TANG, Senior Program Officer PEGGY TSAI, Program Officer CAMILLA YANDOC ABLES, Associate Program Officer KARA N. LANEY, Associate Program Officer RUTH S. ARIETI, Research Associate JANET M. MULLIGAN, Research Associate KAMWETI MUTU, Research Associate ERIN P. MULCAHY, Senior Program Assistant viÂ
   Acknowledgments    This report has been reviewed in draft form by persons chosen for their diverse perspectives and technical expertise in accordance with procedures approved by the National Research Council Report Review Committee. The purpose of the independent review is to provide candid and critical comments that will assist the institution in making its published report as sound as possible and to ensure that the report meets institutional standards of objectivity, evidence, and responsiveness to the study charge. The review comments and draft manuscript remain confidential to protect the integrity of the deliberative process. We thank the following for their review of the report: Greg Baker, South Australian Research and Development Institute, Adelaide Mark Hoddle, University of California, Riverside Frances Homans, University of Minnesota, St. Paul Russell Messing, University of Hawaii, Kapa'a Keith Pitts, Marrone Bio Innovations, Davis, California Wendell Roelofs, Cornell University, Ithaca, New York (emeritus) Lucía Varela, University of California, Santa Rosa Although the reviewers listed above have provided many constructive comments and suggestions, they were not asked to endorse the conclusions or recommendations, nor did they see the final draft of the report before its release. The review of the report was overseen by Drs. Harley W. Moon, Iowa State University (emeritus) and Fred L. Gould, North Carolina State University. Appointed by the National Academy of Sciences, they were responsible for making certain that an independent examination of the report was carried out in accordance with institutional procedures and that all review comments were carefully considered. Responsibility for the final content of the report rests entirely with the author committee and the institution. vii
  Â
  BOARD ON AGRICULTURE AND NATURAL RESOURCES 500 Fifth Street, NW Washington, DC 20001 Phone: 202 334 3062 Fax: 202 334 1978 E-mail: banr@nas.edu www.dels.nas.edu/banr August 31, 2009 Dr. David Kaplan Assistant Deputy Administrator Director, Emergency & Domestic Programs USDA/APHIS/PPQ 4700 River Road Riverdale, MD 20737 Dear Dr. Kaplan, In February 2009, representatives of the U.S. Department of Agriculture (USDA) Animal and Plant Health Inspection Service (APHIS) approached the National Research Council's Board on Agriculture and Natural Resources (BANR) to ask for an objective technical evaluation of the service's response to two petitions to change the classification of the light brown apple moth (LBAM) from a quarantine-significant pest to a non-actionable/non-reportable pest. BANR assembled a committee of 10 members and charged it with evaluating the scientific basis of policy and regulatory decisions made by APHIS with respect to LBAM and the quality of evidence used by the agency in reaching its decisions. The committee was to determine whether APHIS satisfactorily addressed the specific arguments raised in the petitions for reclassification and whether its analysis of the arguments was balanced, thorough, and clearly articulated (see Appendix A for the committee's statement of task). The members of the committee are pleased to provide this letter report containing their findings. The report represents the consensus of the committee (see Appendix B for committee member biographies). Material for review included the two petitions, the APHIS response (hereafter referred to as the Response), and ancillary Web-based materials. On July 9, 2009, the committee conferred by telephone and decided that additional information from APHIS was needed to permit evaluation of the Response; such information was provided by the agency on July 22, 2009. The committee met on the following 2 days in Washington, DC, at which time it put additional questions to APHIS. APHIS responded to further inquiries regarding the publication status of LBAM regulations in the Federal Register during the next week. The committee deliberated over the new information and the report in a conference call on July 30. The format of this report, a brief document prepared over a short time, is well suited to the task at hand in view of the urgency perceived by the agency in addressing the regulatory ix
  status of a pest species newly discovered in California that is of economic importance elsewhere in its range. First reported in 2006, the moth has been found in 17 California counties; APHIS classified LBAM as a high-risk pest of quarantine significance and in fall 2007 initiated an eradication program in cooperation with the California Department of Food and Agriculture. The two petitions were filed in accordance with Chapter 18 of the USDA Emergency Programs Manual (Floyd et al., 2002), which details criteria for termination of an emergency eradication program. In response to its statement of task, the committee found that APHIS did not "fully consider and address the specific arguments" and did not "conduct a thorough and balanced analysis" supporting the conclusions in its Response. Full consideration would have included a more detailed economic analysis and a more complete response to the argument against eradication. Overall, the committee found that the APHIS Response would greatly benefit from the use of more robust science to support its position. In responding to the petitions, APHIS would be well served by articulating the justification for its actions to the public clearly, and the Response should be revised accordingly. In addition, the LBAM regulations should be published for comment in the Federal Register. Sincerely, May Berenbaum, Chair Committee for the Review of U.S. Department of Agriculture's Animal and Plant Health Inspection Service Response to Petitions to Reclassify the Light Brown Apple Moth as a Non- Actionable Pest x
Next: BACKGROUND »
Review of the U.S. Department of Agriculture's Animal and Plant Health Inspection Service Response to Petitions to Reclassify the Light Brown Apple Moth as a Non-Actionable Pest: A Letter Report Get This Book
The U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) has classified the Light Brown Apple Moth (LBAM)--originally from Australia and confirmed in California in 2007--as an "actionable quarantine significant pest" and has applied its authority to implement a program of quarantine restrictions and eradication, which has been met with some public resistance.
Some have petitioned for the LBAM to be reclassified as a "non-actionable pest" based on the argument that the moth is not a significant pest economically and can be controlled by means other than eradication. APHIS asked the Research Council to evaluate the scientific justification of the draft response APHIS wrote to answer the petitions.
This report from the National Research Council concludes that APHIS is within its broad regulatory authority to classify the LBAM as an "actionable" pest. However, APHIS would benefit greatly from referencing more robust science to support its position, as its draft response did not adequately explain the moth's most likely future geographic distribution in the United States or the level of economic harm it could cause.
Front Matter i–x
BACKGROUND 1–13
REFERENCES 14–16
APPENDIX A Review of U.S. Department of Agriculture's Animal and Plant Health Inspection Service (APHIS) Response to Petitions to Reclassify the Light Brown Apple Moth as a Non-Actionable Pest 17
APPENDIX B Biographical Sketches of Committee Members 18–21


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Analysis of cDNAs encoding the two subunits of crotoxin, a phospholipase A2 neurotoxin from rattlesnake venom: the acidic non enzymatic subunit derives from a phospholipase A2-like precursor
The transcriptional regulator LevR of Bacillus subtilis has domains homologous to both sigma 54- and phosphotransferase system-dependent regulators
Publication : Journal of molecular biology
Two MalT binding sites in direct repeat. A structural motif involved in the activation of all the promoters of the maltose regulons in Escherichia coli and Klebsiella pneumoniae
Team: Archived: Group: Evelyne Richet
Member: Evelyne Richet
Published in Journal of molecular biology - 20 Mar 1991
Vidal-Ingigliardi D, Richet E, Raibaud O
J. Mol. Biol. 1991 Mar;218(2):323-34
The maltose regulons of Escherichia coli and Klebsiella pneumoniae are very similar, comprising three operons that code for the proteins required for the utilization of maltodextrins as a carbon source. The maltose regulon of K. pneumoniae contains two additional operons, pulAB and pulC-O, which allow the use of starch as a carbon source. The promoters of all of these operons are strictly controlled by the activator protein MalT. In this paper, we report a detailed study of the structure and the functional role of the MalT binding sites located in the adjacent and divergent pulAp and pulCp promoters. By biochemical and genetic experiments, we show that the 134 base-pair region separating the transcription start sites of pulAp and pulCp contains four MalT binding sites, which leads us to propose a revised consensus for the asymmetrical nucleotide sequence recognized by MalT (5′-GGGGAT/GGAGG). MalT binds co-operatively to these four sites, contacting the major groove of the DNA helix. The genetic dissection of the pulAp-pulCp region shows that the promoters partially overlap: the two central MalT binding sites, which are in direct repeat, are required for the activation of both promoters. We further show that an analogous pair of directly repeated MalT binding sites is also involved in the activation of two other promoters of the regulon, malEp and malKp. This study, which confirms the striking structural diversity of the promoters of the maltose regulon, suggests that the motif formed by two MalT binding sites in direct repeat is a recurrent feature of these promoters and plays a crucial role in their activation.
Published on: 20 Mar 1991


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What is a Callosal Disorder?
Disorders of the corpus callosum are not illnesses or diseases, but abnormalities of brain structure. Many people with these conditions are healthy. However, other individuals with disorders of the corpus callosum do require medical intervention due to seizures and/or other medical problems they have in addition to the disorder of the corpus callosum.
Current research suggests that as many as 1 person in 3,000 is affected by some disorder of the corpus callosum. The rate of diagnosis of these disorders is likely to increase with greater access to the brain scanning technology listed above.
The corpus callosum (call o sum) is the largest connective pathway in a human brain. It is made of more than 200 million nerve fibers that connect the left and right sides (hemispheres) of the brain.
If we cut a brain in half down the middle, we would also cut through the fibers of the corpus callosum. When looking at the middle side of one half of the brain, for example, in magnetic resonance imaging (MRI), the corpus callosum looks like a cross-section of a mushroom cap at the center of the brain.
Each hemisphere of the brain is specialized to control movement and feeling in the opposite half of the body, and each hemisphere specializes in processing certain types of information (such as language or spatial patterns). Thus, to coordinate movement or to think about complex information, the hemispheres must communicate with each other. The corpus callosum is the main connector that allows that communication.
In a typical infant brain, the corpus callosum develops between 12 to 16 weeks after conception (near the end of the first trimester). While the entire structure develops prior to birth, the fibers of the corpus callosum continue to become more and more effective and efficient on into adolescence. By the time a child is approximately 12 years of age, the corpus callosum functions essentially as it will in adulthood, allowing rapid interaction between the two sides of the brain. From this age on (and typically earlier) as the corpus callosum becomes increasingly functional in their typically developing peers, children with ACC appear to fall behind developmentally because the corpus callosum is absent.
Parents often ask if the corpus callosum is the only path between the hemispheres of the brain. It isn't the only path, but it is by far the most important. Some much smaller connections are usually present in DCC. The anterior commissure is the largest and most useful of these other pathways. However, it only has about 50,000 nerve fibers, a far cry from the more than 200 million fibers in the corpus callosum.
The following sections clarify the differences between complete agenesis of the corpus callosum (ACC), partial ACC, hypoplasia of the corpus callosum, and dysgenesis of the corpus callosum.
If the nerve fibers don't cross between the hemispheres during that critical prenatal time, they never will. ACC becomes a permanent feature of the individual's brain. The callosal fibers may have started to grow, but when unable to cross between the hemispheres, they grow toward the back of the same hemisphere where they began. These fibers form what are called Bundles of Probst. Some smaller connections between the hemispheres develop in most individuals with ACC. These are the anterior commissure, posterior commissure, and hippocampal commissure. However, each of these is at least 40,000 times smaller than the corpus callosum. Thus, they cannot compensate completely for the absence of the corpus callosum.
In partial ACC, the corpus callosum began to develop, but something stopped it from continuing. Since the corpus callosum develops from front to back, the part of the corpus callosum that is present in partial ACC usually will be toward the front of the brain, with the back portion missing. Partial ACC includes the entire range of partial absence, from absence of only a small portion of callosal fibers to absence of most of the corpus callosum. In partial ACC, the other smaller commissures usually are present.
Hypoplasia refers to a thin corpus callosum. On a mid-line view of the brain, the structure may extend through the entire area front-to-back as would a typical corpus callosum, but it looks notably thinner. It is unclear in this case if the callosal nerve fibers are fully functional and just limited in number, or if they are both less plentiful and more dysfunctional.
Dysgenesis means that the corpus callosum developed, but developed in some incomplete or malformed way. Thus, partial ACC and hypoplasia of the corpus callosum would be forms of dysgenesis, as would any other form of inadequate callosal development. Dysgenesis is a broad term for any malformation of the corpus callosum that is not a complete absence (agenesis).
Physically, complete ACC is a condition that does not change. It will not get worse. Since the corpus callosum is already absent, it cannot regenerate or degenerate. Likewise, in partial ACC and hypoplasia, once the infant's brain is developed, no new callosal fibers will emerge.
In that sense, disorders of the corpus callosum are conditions one must "learn to live with" rather than "hope to recover from". Long-term challenges are associated with malformation of the corpus callosum, but this in no way suggests that individuals with DCC cannot lead productive and meaningful lives.
These symptoms occur in various combinations and severity. In many cases, they are attributed incorrectly to one or more of the following: personality traits, poor parenting, ADHD, autism spectrum disorders, Nonverbal Learning Disability, specific learning disabilities, or psychiatric disorders. It is critical to note that these alternative conditions are diagnosed through behavioral observation. In contrast, DCC is a definite structural abnormality of the brain diagnosed by an MRI. These alternative behavioral diagnoses may, in some cases, represent a reasonable description of the behavior of a person with DCC. However, they misrepresent the cause of the behavior.