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Adrian Maguire
Partner at Kirkland & Ellis LLP
Adrian's concentration solely on financial sponsor matters means he sees a huge number of transactions, this gives him an almost unrivaled overview of what is going on in various markets.
As well as being highly proficient legally, he is also an avid market watcher. As the markets develop, this puts him in an excellent position to negotiate with third parties on behalf of his client.
Adrian is heavily involved with every stage of a transaction, from the initial stages right through to the close, whether that is a matter of weeks or months or, in some cases, years.
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Partner & Managing Director at Warburg Pincus LLC
US Firms Mostly Hire From Other US Firms in London, 2019 Data Shows
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YOUNG PRETENDERS; James Booth on whether Freshfields can retain its private equity crown
Paths to Adrian Maguire
The University of Durham, commonly known as Durham University, is a public research university in Durham, England. It was founded by Act of Parliament in 1832 and granted a Royal Charter in 1837. It was one of the first universities to open in England for more than 600 years and has a claim towards being the third oldest university in England. Durham is a collegiate university, with its main functions divided between the academic departments of the university and 16 colleges. In general, the departments perform research and provide lectures to students, while the colleges are responsible for the domestic arrangements and welfare of undergraduate students, graduate students, post-doctoral researchers and some university staff.
Kirkland & Ellis LLP provides legal services. The company counsels clients in complex litigation, corporate and tax, intellectual property and restructuring matters. The company was founded in 1909 and is headquartered in Chicago, IL.
Prior - 2019
Freshfields Bruckhaus Deringer LLP
Freshfields Bruckhaus Deringer LLP provides legal services. The law firm specializes in business law & advises corporations, financial institutions, and governments around the world. Its practice areas include antitrust & competition, mergers & acquisitions, corporate finance, tax, employment, real estate, intellectual property, and dispute resolution. The company was founded on August 1, 2000 and is headquartered in London, UK.
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Duluth feminists force cancelation of Garrison Keillor event
Date: March 10, 2020Author: philahistory 0 Comments
Radio personality Garrison Keillor of "A Prairie Home Companion."
By HEATHER BRADFORD
Humorist, radio personality, writer, and unapologetic sexual harasser Garrison Keillor was scheduled to perform on April 16 at the historic NorShor Theatre in Duluth, Minn. The event, which was scheduled during Sexual Assault Awareness Month, immediately attracted social media backlash against the theater. Due to the efforts of local feminist organizers, the anger quickly coalesced into a petition, boycott, plans for a protest, negative media attention, and campaign to call and write the theater to demand that the event be canceled. Ultimately, on March 2, these actions successfully pressured Keillor's booking agency to cancel the event, a decision that NorShor's board refused to make themselves.
To understand why his appearance at the NorShor mobilized Duluth feminists, it is important to review Keillor's history of sexual harassment and abuse of power. In November 2017, Minnesota Public Radio (MPR) severed ties with him. Minnesota Public Radio was the distributor of Keillor's "A Prairie Home Companion," a radio program heard by millions of listeners each week across hundreds of public radio stations since 1974. Keillor had retired from the program in 2016, so the end of their business relationship meant that they would not rebroadcast his episodes, the name would be changed to "Live from Here," and they would no longer distribute his "Writer's Almanac."
At first, Minnesota Public Radio was not forthcoming with details over the firing, which led some listeners to believe he had been falsely accused. Keillor claimed in the Star Tribune, that he had accidentally put his hand six inches up his colleague's shirt when he was trying to console her. Of course, it seems dubious that hands accidentally slip up the shirts of coworkers. The incident occured the same month that he had sent this coworker an email stating that he would like to touch her breast. While there had been sexual emails exchanged between the two of them, his account of the incident minimized the allegations brought against him and ignored power dynamics in the workplace.
In addition to minimizing and denying the allegations, Keillor has also claimed that he is the true victim and argued that the sexual misconduct allegations were actually an extortion scheme by a fired ex-employee who put his accuser up to lying about him.
Of course, MPR did not end its relationship with Keillor over one incident. In their own account released a few months later, they ended their business relationship following an investigation into alleged sexual misconduct which occurred over years Keillor spent working with a woman on "A Prairie Home Companion." The allegations included unwanted touching and sexual harassment, which the employee outlined in a 12-page document.
MPR interviewed over 60 people who had worked with Keillor and released an article with some of the allegations. For instance, Molly Hilgenberg, a former employee of Keillor's bookstore, Common Good Books, recalled an incident in 2012 when he wrote a sexual limerick on a white board about a young female staff member. Hilgenberg said she was afraid to erase it, so she covered it with books. When she finally erased it, Keillor became angry and wrote a condescending non-apology explaining to the sexually harassed worker what a limerick was. In another incident, Keillor sent a sexually inappropriate email to a student when she asked him if she could be his intern. At the time, she didn't share the email as she was afraid that she would not be believed.
In 2009, a subordinate female staff member who was romantically involved with Keillor was asked to sign a confidentiality agreement, wherein she was to agree not to disclose personal or confidential information about him or his company. The agreement was accompanied with a $16,000 check from his production company. She never cashed the check or signed the agreement. In 1999, Patricia McFadden, who worked for "The Writer's Almanac" for three years, was fired from the show, and sued MPR, alleging age, sex, and relational discrimiation after she was replaced by a younger woman. She maintained that the firing was requested by Keillor, who treated female employees in a demeaning, hostile, and abusive manner. He complained when she featured too many female writers and poets for the program. The matter was settled outside of court.
A similar situation was experienced by Liz Fleischman, who also worked for Keillor and watched him crumple up her scripts when he didn't like them. She also learned that she was going to be replaced by a younger woman, but decided to quit her position with "Writer's Almanac." In her observation, he tended to hire younger women, but was often demanding, frustrated, and unappreciative of them.
Although numerous accusations of sexual harassment and abuse of power have been brought against him, Keilor has said that he has nothing to apologize for. He has minimized and denied all accusations brought against him. For instance, he claimed that several sexually suggestive emails that he sent to coworkers were examples of romantic writing. The power dynamics of working as the supervisor of women, and especially younger women, has never been acknowledged. Instead, he has treated the emails as harmless because they never resulted in a physical relationship.
Because he never took accountability for nor issued any semblance of an apology for his behavior, Duluth feminists took several measures to see that his performance was canceled. The immediate response of members of Feminist Justice League and Feminist Action Collective was to contact the NorShor Theatre via phone and Facebook to urge them to cancel the event. Other community members called for a boycott of the NorShor Theatre because of the event. Feminist Justice League launched a petition aimed at the NorShor Theatre to urge them to cancel the performance and had planned a series of protests during the month of March.
The backlash attracted some media attention, which also spotlighted anger over the event. NorShor's board met to discuss canceling the performance and suspended ticket sales for a short time, but ultimately did not decide to cancel it. It was Keillor's booking agent that pulled the plug on the event, saying that it was canceled for "unforeseen circumstances."
Surely, the "unforeseen circumstances" of feminist backlash was not entirely unexpected. In February 2018, Keillor was scheduled to appear at the Burlington Book Festival in Vermont but was forced to cancel due to outcry against his appearance on social media. More recently, social media backlash against Keillor prompted him to cancel a scheduled appearance at the Women's Club of Minneapolis on Feb. 29.
In response to the backlash at the Women's Club, Keillor said that young women seem to view him as a felon or child abductor and that he would rather not fight over it. Again, rather than taking responsibility for his actions, he shifted blame to young women, who for unimaginable reasons, treat him like a villain. In this narrative, he heroically stepped back from the fight so that the Women's Club could have the continued support of young women. Keillor, with a net worth of $5 million and upcoming April performances in Grand Forks, N.D., and International Falls, Rochester, Fairmont, and Mankato, Minn., does not have to be bothered by feminists and past wrongs so long as the money and audiences keep coming.
The #MeToo movement has drawn attention to the sexual misconduct of powerful and famous men such as Harvey Weinstein, Matt Lauer, Al Franken, Neil Degrasse Tyson, Brett Kavanaugh, Louis CK, Bill Clinton, Sherman Alexie, R. Kelly, and scores of others. Powerful men should be held accountable for their abuses. At the same time, as the list of names grows longer and accusations fade out of public consciousness, individual accountability is a losing battle. A part of this struggle is also how sexual harassment is handled in workplaces on a day to day basis.
It is an enormous oversight that for decades Garrison Keillor made numerous female employees feel belittled, harassed, and sexualized. The #MeToo movement did not uncover his behaviors, but created the social conditions in which Minnesota Public Radio felt obligated to fire him. Workplace sexual harassment is more than a matter of individual men exerting power over women; it is also matter of working conditions that serve to silence and instill the fear of firing, retribution, and loss of opportunity. Fifty-four percent of women report sexual harassment at their jobs.
For real empowerment, workers must be agents in uncovering, discussing, developing policies, making decisions, and holding abusers accountable. No one should have as much power as Keillor did over his coworkers, and MPR's hierarchical power structure, like most places of employment, hindered a full investigation of complaints.
DuluthGarrison Keillor
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redpajama_set_name: RedPajamaCommonCrawl


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Onchnesoma
Onchnesoma is one of the two genera that constitute the family Phascolionidae of Phylum Sipuncula, described by Koren and Danielssen established in 1873 as the type species to Onchnesoma steenstrupii.[1][2][3][4][5]
Sipuncula
Sipunculidea
Golfingiiformes
Phascolionidae
Koren & Danielssen, 1875
4 (see text)
The species of this genus are usually small in size (with a trunk of less than 1 cm in length). The introverted is much longer than the trunk. The body wall muscle layers presents continuous. The disc may present oral tentacles (usually less than 10 and about 8 mm. in length) arranged around the mouth, but those tentacles can be reduced in size or completely absent. The retractor muscle system is a highly modified introverted form fused to form a muscle retractor. The anus is located in the distal half of introverted. Gallbladder contractile is rarely observed and if present is without villi. They have a single nephridium.[3][5][6][7]
SpeciesEdit
Onchnesoma intermedium Murina, 1976[3][5][8]
Onchnesoma magnibathum Cutler, 1969[3][5][9][10]
Onchnesoma squamatum (Koren y Danielssen, 1875)[3][5][11]
Onchnesoma steenstrupii Koren y Danielssen, 1875[3][5][11]
^ Stephen, A. C., and. Edmonds S. J. (1972): The Phyla Sipuncula and Echiura. vii+528 Trustees of The British Museum of Natural History. London. ISBN 0-565-00717-3
^ Ditadi, A.S.F. & Migotto, A.E. (1982): O Filo Sipuncula. Concelho Nacional de Desemvolvimento Cientifico e Tecnologico CNPq Brasilia. 43p.
^ a b c d e f Cutler, Edward B. & Cutler, Norma J (1985): A revision of the genera Phascolion Théel and Onchnesoma Koren and Danielssen (Sipuncula). Proceedings of Biological Society of Washington 94(4):809-850
^ Cutler, Edward B. & Gibbs, Peter E. (1985): A Phylogenetic analysis of higher taxa in the Phylum Sipuncula. Systematic Zoology 34(2):162-173.
^ a b c d e f Cutler, Edward B. (1994): The Sipuncula: their systematic, biology and evolution. Comstock Publishing Associates of Cornell University. Ithaca, New York. 406p ISBN 0-8014-2843-2 Google Books
^ Cutler, Edward B. (1973): Sipuncula of the Western North Atlantic. Bulletin of American Museum of Natural History, 152(3):103-203.
^ Gibbs, Peter E and Cutler, Edward B. (1987): A classification of the phylum Sipuncula. Bulletin of the British Museum (Natural History) Zoology, 52(1):43-58
^ Murina, V.V. (1976): New and rare species of sipunculida from the East China Sea. Vestnik Zoologi, 2:62-67
^ Cutler, Edward B. (1969): New species of Sipuncula from western North Atlantic. Proceedings of Biological Society of Washington, 82:209-218.
^ Smithsonian National Museum of Natural History. Antarctic Invertebrates: Onchnesoma magnibathum Cutler, 1969 http://invertebrates.si.edu/antiz/taxon_view.cfm?ScreenWidth=1003&ScreenHeight=567&taxon=8585&MODE=taxon
^ a b Koren, J. and Danielssen, D.C. (1875): Bidrag de norskr Gephyreens Naturhistorie. Nytt. Magasin for Naturvidenskapene, 21:201-138.
Wikispecies has information related to Onchnesoma.
World Register of Marine Species (WoRMS) Onchnesoma Koren & Danielssen, 1876 AphiaID: 136024
Integrated Taxonomic Information System (ITIS): Onchnesoma Koren and Danielssen, 1875 Taxonomic Serial No.: 154722
Retrieved from "https://en.wikipedia.org/w/index.php?title=Onchnesoma&oldid=1073051718"
This page was last edited on 20 February 2022, at 19:45 (UTC).


In all the excitement and public campaigns about the importance of recycling, the other two R's—reducing and reusing—are often forgotten. Reducing and reusing can be even more significant than recycling in that they eliminate any waste or energy spent in the first place. To that end, a campaign to replace bottled water with water fountains and reusable water bottles was initiated in collaboration with the New York State I Love NY Water Campaign. Laminated signs declaring, "Freefill Stations" were posted on all school water fountains to remind students of the 'tested, sustainable, and free' water available to them.
Additionally, reusable water bottles were distributed during Earth Week. The bottles were an enormous hit, with fifty gone in under ten minutes. The student body was quite excited about the bottles. As one student said, "these bottles, together with the signs posted, will really help reduce my water bottle buying habit!" Stickers declaring "I [heart] NY water" were also distributed, with students taking them and sticking them on phones, backpacks, and their new water bottles. Hopefully, the combination of the signs with the sticker and water bottle distribution will help raise awareness of the importance of reducing and reusing, and decrease the amount of waste put out by Yeshiva University students.


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BME posts a net profit of €33.1 million in the third quarter, up 6.8% year on year
Net profit in the first nine monthsof 2013 totalled €105.2 million, up 0.1% yoy
Quarterly revenues increase 2.8% from the third quarter in 2012
Operating costs decrease 2.8% in the third quarter and 1% to the end of September
The efficiency ratio for the first nine months stands at 32.9%, 15 points above the sector average
Return on equity (ROE) from January to September increases to 34.7%, more than 22 points above the sector average
Total investments flows channelled through the exchange in the first nine months amounted to €25.6 billion (+27.7%)
BME reported net profit of €33.1 million for the third quarter of 2013, an increase of 6.8% year-on-year. In the first nine months of 2013, net profit amounted to €105.2 million, an increase of 0.1% from the same period last year. Year-on-year comparisons of cumulative net profit turned positive for first time after previous quarters showed declines.
Revenues rose 2.8% year-on-year in the third quarter of 2013 to €72.5 million. In the first nine months of the year revenues decreased 1.4% year-on-year to €225.9 million. This has allowed a 1.9% reduction from the -3.3% reported at the end of the previous quarter. Equity trading was the largest driver of revenue growth in the third quarter. Revenue and EBITDA in the Equity unit rose 11.6% and 17.7% year-on-year, respectively.
Operating costs totalled €23.7 million in the third quarter of 2013 and €74.4 million in the first nine months, signalling decreases of 2.8% and 1%, respectively, from the same periods last year.
Aggregate earnings per share in the first nine months of 2013 were €1.26, of which €0.40 related to the third quarter.
Among the main financial management indicators, the efficiency ratio for the first nine months was 32.9%, more than 15 points above the sector average. ROE in the first nine months improved 2.3% and stood at 34.7%, more than 22 points above the sector average.
Revenues for the Equity unit rose 11.6% year-on-year in the third quarter of 2013 to €29 million. EBITDA for the same period was up 17.7% from a year earlier, at €21.5 million. In the first nine months of the year, revenues and EBITDA fell 3.3% and 3.6% from the previous year, respectively, to €83.2 million and €59.9 million.
The number of equity trades rose 42% year-on-year in the third quarter to 12.6 million. Turnover in equities in the third quarter increased by 3% from a year earlier, to €158.2 billion.
In the Settlement and Registration unit, revenues through September amounted to €61.8 million (+2.3%), of which €18.4 million were obtained in the third quarter of 2013 (-3.6%). EBITDA for these services amounted to €15.1 million in the third quarter, posting a year-on-year decline of 1.6% and €51.6 million in the nine-month period, an increase of 4.3% from last year.
The nominal volume registered for Fixed Income (both private and public) and equities at the end of the third quarter amounted to €2.2 trillion, up 4.4% from the third quarter of 2013.
The use of capital instruments in the form of rights issues and scrip dividends remained strong in the third quarter. Investment flows channelled through the exchange in the third quarter amounted to €6.1 billion, taking the total for the first nine months of the year to €25.6 billion, 27.7% higher than in the same period a year earlier.
Investment flows in shares already admitted to trading in the third quarter included €2.9 billion of scrip dividends and BBVA's capital increase. Scrip dividends rose 21% year-on-year to €7.8 billion in the first nine months of 2013, with a 49.7% increase in the third quarter relative to a year earlier.
Revenue for the Listing business amounted to €4.8 million in in the third quarter of 2013 (+1.1%) and €14.8 million in the first nine months of the year (-8.5%). EBITDA showed an increase of 4.4% to €2.6 million in the third quarter and €8 million in the nine-month period, marking a decrease of 13.5% from the same period last year.
Revenues from Information services totalled €8.1 million in the third quarter (-5.2%) and €24.5 million in the first nine months of the year (-6%). EBITDA amounted to €6.3 million in the third quarter and €19 million in the first nine months of 2013, down 6% and 7.5% from the same periods last year.
The total volume of contracts traded in the Derivatives unit fell 25.2% in the third quarter of 2013 and 27.3% in the first nine months of the year, both from the same periods a year earlier.
Revenues for the Derivatives unit in the third quarter fell 0.7% year-on-year to €6.5 million but were still up in the nine-month period by 5% from a year earlier, at €20.1 million. EBITDA totalled €3.8 million in the third quarter of 2013 and €11.7 million in the first nine months, marking year-on-year increases of 1.7% and 11.7%, respectively.
Total trading in the unit fell 54% year-on-year in the third quarter, to €272 billion. However, the number of trades executed in the period rose by 55.9%, helping temper the fall in turnover. Through 30 September, Fixed Income turnover was down 43.3% from a year earlier, with 8.2% fewer trades.
Operating revenues in the Fixed Income unit rose by 2.2% year-on-year in the third quarter of 2013 to €1.9 million, but fell 9.6% year-on-year in the nine-month period to €6.5 million. EBITDA increased by 6.3% year-on-year in the third quarter of 2013, to €1.1 million, but declined by 13.3% from the previous year in the first nine months, to €4.2 million.
IT & CONSULTING
Revenue from the IT & Consulting unit performed in positive in the third quarter, rising 2.3% year-on-year and taking the cumulative gain in the first nine months of 2013 to 9.7% from a year earlier. The unit's various activities obtained revenues of €3.9 million in the third quarter and €13.3 million in the nine-month period this year. EBITDA for the unit rose 18.1% in the third quarter of 2013 to €1.5 million and was up 35.3% year-on-year in the nine-month period, at €5.8 million.
In technical infrastructure, more clients have been added to BME's co-location infrastructure service, rolled out in April, meanwhile the number of clients connected "in proximity" from London increased by 44.4% since September last year. The area of production, contingency (BME Alternative) and cloud (BME Incloud) solutions received a commercial boost through bundled offers combining the three services.
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Anticoagulation Reference Centre
Consultative advice
Anticoagulation guidelines
NOAC monitoring
Anticoagulation news items. Week commencing 30th October 2017
Use of oral anticoagulants in combination with antiplatelet(s) in atrial fibrillation
Analysis of Danish registry data (n=2946) found that from 2011 to 2016, the use of a NOAC in combination with antiplatelet(s) increased from 10% to 52% in patients with AF following MI/PCI, and exceeded the use of vitamin K antagonist in combination with antiplatelet(s) by 2016.
Hospital admissions for bleeding events associated with treatment with apixaban, dabigatran and rivaroxaban
European Journal of Hospital Pharmacy
Retrospective observational study identified 37 hospitalisation episodes for DOAC-induced bleeding in 32 patients (15 rivaroxaban, 9 apixaban, 8 dabigatran), representing incidence rate of 3.44/ 100 person-years. Most common bleeding site was GI. Intracranial bleeding was rare.
US FDA approves 10mg dose of rivaroxaban for reduction of continued risk of venous thromboembolism (VTE)
Biospace Inc.
FDA has approved 10 mg dose for reducing continued risk for VTE after completing at least 6-months of initial anticoagulation. Approval is based on data from EINSTEIN CHOICE, which showed superior efficacy in reducing VTE risk and with major bleeding rates similar to aspirin.
International Expert Consensus on Switching Platelet P2Y12 Receptor-Inhibiting Therapies
This expert consensus provides an overview of the pharmacology of P2Y12 inhibitors, different modalities and definitions of switching, and available literature and recommendations for switching between P2Y12 inhibitors.
Bayer files for approval of long-acting haemophilia therapy damoctocog alfa pegol (BAY94-9027) in US
PharmaTimes
BAY94-9027 is engineered to potentially prolong factor VIII activity in the blood while preserving coagulation activity using site-specific PEGylation technology, thus reducing the number of infusions necessary to prevent bleeds in patients with haemophilia A.
Revised SPC: Pradaxa (dabigatran) hard capsules (all strengths)
electronic Medicines compendium
Sections 4.2 (Posology and method of administration), 4.4 (Special warnings and precautions for use) and 5.1 (Pharmacodynamic properties) have been updated to include information regarding catheter ablation for atrial fibrillation.
Revised SPCs: Xarelto (rivaroxaban) film-coated tablets (all strengths)
As with other anticoagulants, the possibility may exist that patients are at increased risk of bleeding in case of concomitant use with SSRIs or SNRIs. When concomitantly used in the clinical program, numerically higher rates of clinically relevant bleeding were observed.
The Efficacy and Safety of the Use of Non-Vitamin-K Antagonist Oral Anticoagulants in Patients with Non-Valvular Atrial Fibrillation and Concomitant Aspirin Therapy: A Meta-Analysis of Randomized Trials
This analysis of 4 RCTs found that in patients receiving aspirin (n=21,722), NOACs were more effective than vitamin K antagonists (e.g. HR 0.78; 95% CI 0.67-0.91 for stroke/systemic embolism), as safe for major bleeding and safer for intracranial haemorrhage (HR 0.38; 0.26-0.56).
Conference report: Three months of dual antiplatelet therapy (DAPT) non-inferior to 12 months DAPT in patients with acute coronary syndrome (ACS) treated with the COMBO Dual Therapy Stent
The overall incidence of the primary endpoint (composite of all-cause mortality, myocardial infarction, stent thrombosis, stroke, target vessel revascularisation, moderate/major bleeding within 360 days) was 8.2% for 3 months v 8.4% for 12 months DAPT; P non-inferiority <0.001).
Lower dose of rivaroxaban (Xarelto) for extended prevention of recurrent venous thromboembolism (VTE) approved in Europe
The European Commission has approved a 10mg once daily dose for extended prevention of recurrent VTE, for patients who have already received at least six months of initial anticoagulation. The approval is based on data from the EINSTEIN CHOICE study.
The above records have been identified by UKMi and feature in the NICE Medicines Awareness Service. Further details on this service can be found at:
http://www.evidence.nhs.uk/about-evidence-services/content-and-sources/medicines-information/new-medicines-awareness-services
Anticoagulation news items. Week commencing 23rd October 2017
Pregnancy, thrombophilia, and the risk of a first venous thrombosis: systematic review and bayesian meta-analysis
This review of 36 cohort or case-control studies (41,297 reported pregnancies) found all inherited thrombophilias increased the risk for pregnancy associated VTE, with the highest risks seen for antithrombin, protein C and protein S deficiency, and homozygous factor V Leiden.
Less dementia with oral anticoagulation in atrial fibrillation
Swedish retrospective registry study (n=444,106) found anticoagulant treatment at baseline was associated with 29% lower risk of dementia than in patients not on anticoagulant [HR 0.71, 95% CI, 0.68–0.74]. Direct comparison between DOACs and warfarin showed no difference.
Streamlining primary and secondary care management pathways for stroke prevention in atrial fibrillation
This article outlines the collaborative working between primary and secondary care in one CCG in the development of a simple and practical decision-making pathway for stroke prevention in atrial fibrillation.
Anticoagulation news items. Week commencing 9th October and 16th October 2017
Safety and efficacy of long-term treatment of chronic/persistent ITP with eltrombopag: final results of the EXTEND study
Over median duration of 2.37 years, 259 patients (85.8%) achieved response (platelets ≥50×109/L at least once in absence of rescue) and 133 of 257 (52%) achieved continuous response ≥25 weeks. Rate of thromboembolic events (6%) did not increase with treatment duration past 1 year.
Comparative safety of direct oral anticoagulants and warfarin in venous thromboembolism: multicentre, population based, observational study
Retrospective study (n=12,489 on DOACs and 47,036 on warfarin in Canada and US with new diagnosis of venous thromboembolism) found treatment with DOACs, compared with warfarin, was not linked to increased risk of major bleeding or all-cause mortality in first 90 days of treatment.
Co-administration of cyclosporine and ticagrelor may lead to a higher exposure to cyclosporine: a case report of a 49-year-old man
Timeline for increase in trough level of cyclosporine after introduction of ticagrelor (TC) for unstable angina was considered consistent with appearance of an interaction, thought to be due to inhibition of CYP3A4 and P-glycoprotein by TC, which was managed by cessation of TC.
Anticoagulation news items. Week commencing 2nd October 2017
Venous thromboembolism in over 16s: reducing the risk of hospital-acquired deep vein thrombosis or pulmonary embolism (Update): Draft guidance consultation
National Institute for Health and Care Excellence
A DRAFT update of NICE guideline CG92 (published January 2010), which includes new and updated recommendations on the risk assessment and prophylaxis of people at risk of venous thromboembolism, is now available for consultation.
Bayer halts Phase III study of rivaroxaban in embolic stroke
Bayer has halted a Phase III study investigating rivaroxaban in patients with embolic stroke of undetermined source after it showed no improvements in efficacy when compared to aspirin. Bleeding rates were low overall but higher in the rivaroxaban arm (no data presented).
In Use Product Safety Assessment report for Inhixa (enoxaparin biosimilar)
Specialist Pharmacy Service
This assessment, produced using the validated UKMi product assessment tool, discusses practical safety considerations associated with the introduction of this biosimilar product, including the need to ensure prescribing of product by brand name.
Anticoagulation combined with antiplatelet therapy in patients with left ventricular thrombus after first acute myocardial infarction
Review (n=1850 with MI) found that among those with a left ventricular thrombus given a vitamin K antagonist, those with a time in therapeutic range (TTR) ≥50% had a lower risk of thromboembolism vs those with TTR <50% (2.9% vs 19%, p=0.036) with no difference in major bleeding.
Indications for anticoagulant and antiplatelet combined therapy
Review notes combination treatment increases risk of bleeding, and this risk should be estimated and discussed with patients to guide treatment decisions (e.g. using risk scores such as HAS-BLED). Consideration should be given to addition of H2 antagonist or proton pump inhibitor.
Association Between Use of Antithrombotic Medication and Hematuria-Related Complications
Journal of the American Medical Association
Canadian retrospective cohort study (n=808,897) found that over a median follow-up of 7.3 years the rate of haematuria complications was higher in those exposed to antithrombotics vs those not exposed (123.95 vs 80.17 per 1000 person years, Rate Ratio 1.44, 95% CI 1.42-1.46).
Association Between Use of Non–Vitamin K Oral Anticoagulants With and Without Concurrent Medications and Risk of Major Bleeding in Nonvalvular Atrial Fibrillation
Taiwanese study (91,330 patients on NOACs) found that those on concurrent amiodarone, fluconazole, rifampicin and phenytoin had a significant increased risk of major bleeding vs NOAC use alone (difference +13.94, +138.46 +36.90 and +52.31 incidents per 1000 person years).
Clinical impact of major bleeding in patients with venous thromboembolism treated with factor Xa inhibitors or vitamin K antagonists
Thrombosis and Haemostasis
Combined data from the EINSTEIN, AMPLIFY and HOKUSAI-VTE studies found that factor Xa inhibitor associated major bleeding events in these studies had a less severe presentation and similar course compared to vitamin K antagonists.
Shortage of abciximab (Reopro) 2mg/ml solution for injection or infusion
There is a potential 6 month supply issue affecting abciximab from October through till March 2018. This memo advises on alternative treatment options in the interim should stock run out.
Low-Dose vs Standard-Dose Alteplase for Patients With Acute Ischemic Stroke: Secondary Analysis of the ENCHANTED Randomized Clinical Trial
This secondary analysis of a RCT that involved 3310 patients with acute ischaemic stroke found no clear differential benefits of low-dose alteplase compared with standard-dose alteplase in disability outcomes, irrespective of age, race/ethnicity, and neurological severity.
Anticoagulation news items. Week commencing 25th September 2017
Miconazole (Daktarin): over-the-counter oral gel contraindicated in patients taking warfarin
Medicines and Healthcare products Regulatory Agency
Patients taking warfarin should not use over-the-counter miconazole oral gel. If concomitant use is planned via prescription, the anticoagulant effect of warfarin should be monitored carefully. Patients who experience signs of bleeding should seek immediate medical attention.
Meta-Analysis of Safety and Efficacy of Uninterrupted Non–Vitamin K Antagonist Oral Anticoagulants Versus Vitamin K Antagonists for Catheter Ablation of Atrial Fibrillation
Review of 13 studies (3 RCTs and 10 observational studies, total n=4,878) found no significant difference in the risk of major bleeding, systemic thromboembolism and symptomatic stroke/TIA, though the evidence was not of high quality.
Evolving landscape of stroke prevention in atrial fibrillation within the UK between 2012 and 2016: a cross-sectional analysis study using CPRD
Cohort study showed an increasing proportions of patients with non-valvular AF receiving anticoagulant therapy (16.7% rise), together with similar reductions in antiplatelet (16.8% decrease). The proportion of patients not receiving antithrombotics remained the same (15%).
Effect of Genotype-Guided Warfarin Dosing on Clinical Events and Anticoagulation Control Among Patients Undergoing Hip or Knee Arthroplasty: The GIFT Randomized Clinical Trial
RCT (n=1,650) found that fewer patients in the geno-type guided group had a composite outcome event (major bleeding, INR>4, VTE or death) vs clinically guided warfarin (10.8% vs 14.7%, RR 0.73, 95% 0.56 to 0.95).
Phase III L-PLUS2 study investigating lusutrombopag for the treatment of thrombocytopenia in patient with chronic liver disease undergoing elective invasive procedures meets primary endpoint
This study (n=215) reports that more patients on lusutrombopag vs placebo (64.8% vs 29.0%) met the primary efficacy endpoint (defined as proportion of patients who required no platelet transfusion prior to the invasive procedure) and no rescue therapy for bleeding post procedure.
Interhospital Transfer Prior to Thrombectomy is Associated with Delayed Treatment and Worse Outcome in the STRATIS Registry
Median onset-to-revascularisation time was 202 minutes for direct presentation vs 311 minutes for interhospital transfer in 984 patients undergoing mechanical thrombectomy for severe stroke (p<0.001). Mortality did not differ and IV alteplase did not impact outcomes.
New Drug Application submission to FDA for avatrombopag, an oral second generation thrombopoietin receptor agonist
The NDA was based on data from two Phase III trials, ADAPT-1 and ADAPT-2, that evaluated the efficacy and safety of avatrombopag for the treatment of severe thrombocytopenia (<50,000/μL) in patients with chronic liver disease who are scheduled to undergo a procedure.
Diagnosis and management of postpartum haemorrhage
Review notes this is second leading direct cause of maternal deaths in UK. It recommends tranexamic acid for all women with atonic and traumatic postpartum haemorrhage as well as for ongoing haemorrhage during a caesarean section.
National community pharmacy oral anticoagulant safety audit
This audit will provide insight on patient awareness of key information about their anticoagulant, use of alert cards and compliance with monitoring requirements. Results will be used to inform a national update of patient held oral anticoagulant information and alert cards.
Screening for Occult Cancer in Patients With Unprovoked Venous Thromboembolism: A Systematic Review and Meta-analysis of Individual Patient Data
10 studies (n=2,316) found a 12 month prevalence of cancer after VTE of 5.2%. The point prevalence of cancer was higher in those with extensive screening vs limited screening initially (OR 2.0, 95% CI 1.2 to 3.4), but not at 12 months (OR 1.4, 95% CI 0.89 to 2.1).
Effects of Anticoagulants in Patients With Cirrhosis and Portal Vein Thrombosis: A Systematic Review and Meta-analysis
Review of 8 studies (n=353) found that more patients given anticoagulants underwent portal vein thrombosis recanalization vs no treatment (71% vs 42%, p<0.0001). There was no difference in major or minor bleeding in the 6 studies that reported this.
Bleeding-related hospital admissions and 30-day readmissions in patients with non-valvular atrial fibrillation treated with dabigatran versus warfarin
Journal of Thrombosis and Haemastasis
Dabigatran vs warfarin, was associated with comparable incidence of first hospital admission (incidence rate ratio, 0.92; 95% CI, 0.66-1.28) but higher risk of 30-day readmission with respect to bleeding (adjusted HR, 2.87; 95%CI, 1.10-7.43) in 51,946 Hong Kong patients with AF.
The management of antiplatelet therapy in acute coronary syndrome patients with thrombocytopenia: a clinical conundrum
In the absence of clinical guidance, this review discusses the evidence and proposes management strategies for antiplatelet therapy in patients with acute coronary syndrome and thrombocytopenia.
Rivaroxaban vs Warfarin Sodium in the Ultra-Early Period After Atrial Fibrillation–Related Mild Ischemic Stroke A Randomized Clinical Trial
This RCT (n=195) reports in patients with mild acute ischaemic stroke and AF, new ischaemic lesions or intracranial haemorrhage (noted on MRI imaging) after 4 weeks occurred in 49.5% of patients receiving rivaroxaban v 54.5% receiving warfarin (nonsignificant difference, p=0.49).
Long-term mortality and prehospital tirofiban treatment in patients with ST elevation myocardial infarction
Subgroup analysis of the On-TIME 2 trial (n=984) found that baseline N-terminal pro-B-type natriuretic peptide level predicted long-term mortality. In those with high levels, early prehospital treatment with tirofiban significantly reduced 30-day and 1-year mortality vs placebo.
Factor VIII medicines: no clear and consistent evidence of difference in risk of inhibitor development between classes
The European Medicines Agency has concluded there is no clear evidence of a difference in risk of inhibitor development between recombinant factor VIII medicines and those derived from plasma. The risk of inhibitor development should be evaluated individually for each medicine.
Anticoagulation news items. Week commencing 4th September 2017
Pharmacovigilance Risk Assessment Committee (PRAC) confirms its previous conclusion on risk of inhibitor development with factor VIII medicines
The PRAC has confirmed its previous conclusion that there is no clear and consistent evidence of a difference in the incidence of inhibitor development between the two classes of factor VIII medicines: plasma-derived and made with recombinant DNA technology.
Anticoagulation news items. Week commencing 28th August 2017
Guided de-escalation of antiplatelet treatment in patients with acute coronary syndrome undergoing percutaneous coronary intervention (TROPICAL-ACS): a randomised, open-label, multicentre trial
Guided de-escalation of antiplatelet therapy (one week prasugrel then one week clopidogrel, followed by maintenance treatment dictated by platelet function testing) was non-inferior to 12 months prasugrel for net clinical benefit at one year (7% v 9%; HR 0.81; 95% CI 0.62-1.06]).
Dual Antithrombotic Therapy with Dabigatran after PCI in Atrial Fibrillation
In patients with AF who had undergone PCI (n= 2725), dabigatran (110 mg or 150 mg bd) plus P2Y12 inhibitor (clopidogrel or ticagrelor) resulted in risk of major or clinically relevant non-major bleeding events that was significantly lower than risk with warfarin triple therapy.
Rivaroxaban with or without Aspirin in Stable Cardiovascular Disease
In patients with stable atherosclerotic vascular disease (n=27,395), rivaroxaban (2.5 mg bd) plus aspirin led to better CV outcomes but more major bleeding events vs aspirin. Rivaroxaban (5 mg bd) did not result in better CV outcomes vs aspirin and more major bleeding events.
A multifaceted intervention to improve treatment with oral anticoagulants in atrial fibrillation (IMPACT-AF): an international, cluster-randomised trial
Educational intervention (providers and patients, with regular monitoring and feedback), aimed to improve use of oral anticoagulation in patients with AF, resulted in an increase in patients treated with oral anticoagulants (68% to 80%) vs usual care (64% to 67%).
Bivalirudin versus Heparin Monotherapy in Myocardial Infarction
This Swedish registry-based study (n=6006) reports among patients undergoing PCI for MI, the rate of the composite of death from any cause, MI, or major bleeding was similar among those who received bivalirudin vs heparin monotherapy (12.3% vs 12.8%, HR 0.96; p=0.54).
Anticoagulation news items. Week commencing 21st August 2017
FDA grants priority review to licensing application for haemophilia drug emicizumab
Reuters Health
Roche said submission is based on positive data from phase 3 study in adolescents/adults with haemophilia A with inhibitors (IHs) and interim phase III results in children. It said ~30% patients develop IHs limiting treatment options and increasing risk of life-threatening bleeds.
NIHR Signal: Drug reduces deaths from bleeding after childbirth
National Institute for Health Research Signal
Expert commentary is provided for an RCT (20,600 women with post-partum haemorrhage) which found that IV tranexamic acid reduced the risk of death from bleeding vs placebo. The challenge is to promptly implement the early use of tranexamic acid into best practice.
Predicting major bleeding in patients with noncardioembolic stroke on antiplatelets. S2TOP-BLEED
A prediction model for major bleeding in patients with a TIA or ischaemic stroke on antiplatelets was developed following review of data from 6 RCTs. Authors claim that the S2TOP-BLEED score had a reasonable external validation but slightly underestimated the major bleeding risk.
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Check out our photo gallery for before and after pics, quality work is in our detail!
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These are the most comfortable cushiony shoes! I just love them. I work in a hospital and put tons of miles on my shoes and love how springy these shoes are. I also appreciate that there is no extra stitching or material around the fore foot which can sometimes bother my feet due to swelling. Fresh Foam Vongos and these 1080's are awesome! Thank you NB!


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I am sure, however, that he would have had no trouble in the delivery of a beautiful tapestry of prose dedicated to describing what this will mean for New Zealand's future. The darkest clouds often precede the brightest dawn. Read More …..


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Review: 10.5-inch iPad Pro is the 'Goldilocks' edition. It's just right
Apple came mighty close with the 9.7 iPad Pro, but with its new 10.5in iteration it really has created a machine to properly replace your laptop
By Jeremy White
Class-leading screen; super powerful; fine audio; just the right size
Similar price to MacBook; slightly squashed keys; needs iOS 11
The perfect laptop killer. Apple's formidable 10.5-inch iPad Pro
Apple had so much to announce at last month's WWDC keynote – both hardware and software – that the company couldn't actually fit everything into its 140-minute presentation. Some good stuff got cut from the stage show, including a lovely new wireless keyboard complete with number pad (WIRED likes this kind of stuff, so hold your sniggering).
The biggest reveals were undoubtedly the HomePod, the new iMac Pro and this, the 10.5-inch iPad Pro. It replaces the 9.7-inch iPad Pro and joins the 12.9-inch iPad Pro iPad Pros, which seems weird when you consider the smaller iPad Pro is barely a year old. How much difference can 0.8-inches make? A lot, as it happens.
You see, the iPad Pros are partly aimed at convincing you that with a bump in specs and performance you no longer need to lug around a heavier laptop – especially if what you mainly do with it is email, web, media, docs and spreadsheets (i.e. practically everyone, then). WIRED has used the 9.7-inch and 12.9-inch iPad Pros extensively and one is slightly too small for prolonged working, the other perhaps a little too bulky for those used to traditional tablet weights and dimensions.
This is where the 10.5-inch version comes in – the "Goldilocks" iPad Pro. At least that's what Apple wants us to think: not too big and not too small – but juuust right. And, you have to hand it to Apple, it's got it practically spot on. There's the bigger and better screen; the faster chip with more RAM; and its even got an enlarged Smart Keyboard, more of which later – all in a package using virtually the same real estate as the 9.7-inch Pro, making that version instantly obsolete.
The real reason Jony Ive left Apple
By John Arlidge
It's an iPad. Which means the following: glass front, aluminium body, precisely chamfered metal edges, well-defined corners and solid, dependable buttons and the usual ports in the usual places.
Where Apple has departed from convention is the screen. The side bezels have been pushed out to accommodate a screen that is almost an inch greater on the diagonal. Yes, the tablet size has been increased marginally to help achieve this – squeaking up from 9.4 x 6.6 inches to 9.8 x 6.8 inches – but that reduced bezel is what really counts.
Now, some, frothing at the mouth at the prospect of any significant design change on the iPad, have gone as far as to say that this 10.5 Pro is "practically bezel free!" This is patently rubbish. The bezels are right there, clear as day, and still reasonably chunky at the top and bottom of the screen. You will notice the difference, however. The extra inch makes a big difference to viewing media and split-screening apps. But WIRED cannot help but imagine how this experience will be if Apple ever produces truly bezel-free iPads.
Apple has pushed out the side bezels on the iPad Pro 10.5 to give another inch of screen space
The new design is heavier, but marginally (just 30g, going from 437g to 467g) that it will more than likely go unnoticed.
Dark Mode and Maps Look Around are iOS 13's highlights (so far)
By Andrew Williams
Apple has made much of the fact that it has managed to squeeze a full-size keyboard onto its Smart Cover for the 10.5 iPad. And it has indeed. What's more it works very well and allows fast typing, just like the previous Smart Keyboards.
However, although all the keys are actually on there, they have definitely been squeezed on in places. It takes some getting used to, and if you type fast you will, for at least a short period of time, find yourself bashing the wrong keys as you habitually reach for a character at the edge of the keyboard that isn't quite in the location you think it is.
The "full-size" Smart Keyboard on the Apple iPad Pro 10.5
The camera is now bigger, of course, which is likely down to the fact that the iPhone 7 lens assembly used takes up more space than the 6S camera the previous 9.7-inch iPad Pro had. And the TouchID sensor, now upgraded to the second generation you get in the iPhone 6S and 7, is indeed faster.
The new screen is the star of the show here, though. The 10.5-inch Pro has a 2224×1668 display, up from 2048×1536 in the 9.7. The benefits of the anti-reflective coating, seen in recent iMacs and MacBook Pros, are obvious. As is the True Tone feature, which analyses the colour temperature of the iPad's ambient light and adjusts the display's temperature to match it.
Jony Ive's replacement rescued the first iPhone from disaster
The 10.5-inch iPad Pro camera is bigger, using the iPhone 7 lens assembly
Where Apple has perhaps been most innovative is the screen variable refresh rate, dubbed "ProMotion". The iPad's refresh rate has been doubled from 60Hz up to a top whack of 120Hz, but to stop this bump in performance murdering the battery Apple has improved the tech seen in the last-gen Pro, which let the iPad drop the refresh rate from 60Hz to 30Hz when displaying static or slow-moving content. Now, however, it can go from 120Hz to 24Hz. This means slick, fluid viewing when you want it but subtle power saving when you won't notice it. Very clever.
It's not all wonderment, though. Along with the squished keys on the Smart Keyboard, on WIRED's test unit it kept crashing Notes, while copying and pasting anything other than very small amounts of text resulted in odd delays, as if the iPad had to stop and think for a moment.
[article id="mQVgb59OZRE"]
Also, WIRED loves the speaker system in the 12.9-inch iPad Pro – it truly is astonishing with great volume and surprisingly good tone and nice bass for in-built speakers on a tablet. Apple could not replicate this in the 9.7-inch version, sadly – and we could instantly tell the difference. While the audio was perfectly fine, it was not a patch on the setup in big brother. Frustratingly, the middle sibling here doesn't get the 12.9-inch audio kit either. It is perhaps the only thing stopping the 10.5 being practically perfect.
Apple's iPad Pro 10.5 speaker system is not quite as punchy as the formidable 13in version
One important last word of caution. Despite the score, WIRED would not recommend getting a 10.5 iPad Pro until iOS 11 comes out. This welcome overhaul of the operating system will bring more than a few Mac OS essentials to the iPad, such as drag and drop, the new Files app, the expanded dock and Split View. It is this addition, plus the refinements listed above that allows the 10.5 iPad to replace your everyday laptop so well.
Subscribe to WIRED
WIRED went without a laptop for the entirety of this test period, and at no point did we feel the need to revert back to one. The Pro could handle all web, email, file, media needs, and for a much, much longer period thanks to the 30.4‐watt‐hour battery. If you want to go heavy on picture manipulation though, a laptop would still be our recommendation.
But for most, if you can stomach the price with all the accessories (which takes the 10.5 iPad Pro almost into MacBook country) – which is an all-too-common criticism for Apple product – then this is a superb, powerful machine with perhaps the best screen out there. But wait for iOS 11. Apple may drop the price by then. (You're laughing again, aren't you?)
Apple iPad Air review: the best iPad you can buy right now
New iPad Pro vs 2017 iPad Pro. Which one should you get?
By Matt Reynolds
Microsoft's Surface Go is an iPad rival actually worth caring about
By Robert Leedham
33 of the best documentaries on Netflix
By WIRED


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Difference between revisions of "John (Roshchin) of Naro-Fominsk"
Чръный человек (talk | contribs)
(→Biography)
A Holy Synod decision on 25 July 2014 (Journal Number 66) elected him as Administrator of the Patriarchal Parishes in the USA, and vicar bishop of the Diocese of Moscow with the title "Naro-Fominsk".
On August 1st, the Feast of the Uncovering of the Relics of St. Seraphim of Sarov, Patriarch Kirill of Moscow and all Russia served the Divine Liturgy in the Church of St. George the Great Martyr at Poklonnaya Hill. This date commemorates the 100th Anniversary of Russia's entry into the First World War. During the Divine Liturgy Patriarch Kirill led the Episcopal Consecration of Archimandrite John (Roshchin) as Bishop of Naro-Fominsk.
Bishop John (secular name Georgy Yevgenyevich Roshchin, Russian: Георгий Евгеньевич Рощин; 22 October 1974) is priest of the Russian Orthodox Church and elected bishop of Naro-Fominsk, Administrator of the Patriarchal Parishes in the USA.
He graduated from the Moscow Theological Seminary and Moscow Theological Academy.
In 1996-1997, worked as an employee of the Patriarchate of Moscow Publishing Council. In 1997, he joined the staff of the Patriarchate of Moscow Synodal Department for External Church Relations.
In December 1998, he was a member of the Moscow Patriarchate's delegation at the Eighth Assembly of the WCC (Harare, Zimbabwe) and became a member of the WCC Central Committee.
In 2000-2002, he studied at the Faculty of Philosophy at the Catholic University of America (Washington, DC).
From 2003 to 2009, as a member of the Secretariate on Church and Society of the Synodal Department for External Church Relations, he was in charge of inter-religious communication, including interaction with the Interreligious Council of Russia and the SNG Interreligious Council, and international interfaith organizations, was a member of the Commission of the Conference of European Churches "Islam in Europe", participated in the preparation and conduct of the Fourth, Fifth, and Sixth Meetings of the joint Russian-Iranian commission "Islam-Christianity".
On 27 July 2009, the Holy Synod appointed him Deputy Chairman of the Moscow Patriarchate Synodal Department for the Coordination of Church and Society.
In 2009, with the blessing of Patriarch Kirill of Moscow and all the Rus, he was a member of the Council for the Study of Religious Materials to identify extremist materials in the Ministry of Justice. He was the official representative of the Moscow Patriarchate in the Parliamentary Assembly of the Union of Belarus and Russia, a member of the Commission on organising state support and the development of original Cossack culture, a member of the Public Council under the Federal Drug Control Service, and a member of the Public Council under Rosreyestr.
From 2010 to 2013, he was the Executive Secretary of the Interreligious Council of the Commonwealth of Independent States.
On 4 October 2012, the Holy Synod appointed him representative of the World Russian People's Council at the UN and assigned him to St Nicholas Cathedral in New York City.
On 11 March 2014, with the blessing of Patriarch Kirill of Moscow and all the Rus, the Superior of the Trinity - Sergius Lavra, Archbishop Theognost (Guzikov) of Sergiev Posad, tonsured him a monk with the name John in honour of St John (Maximovitch) of Shanghai and San Francisco.
Archimandrite John (Roshchin) Consecrated to the Episcopacy
Retrieved from "https://en.orthodoxwiki.org/index.php?title=John_(Roshchin)_of_Naro-Fominsk&oldid=120053"
Categories > People > Clergy > Bishops
Categories > People > Clergy > Bishops > Bishops by century > 21st-century bishops
Categories > People > Clergy > Bishops > Bishops by city > Bishops of Naro-Fominsk


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Floor is Lava: Where Do The Contestants Go After They Fall?
Before we used to be invested in watching reality series, we used to watch games shows, and before that, we used to watch overly dramatic and mindlessly distracting kids shows. But, even before that, we just used to spend all summer at home jumping from couch to couch, tossing pillows on the ground as imaginary safe pads, hanging onto rods, and climbing up on top of shelves just so we didn't touch the floor and "burn" ourselves.
Netflix's newest reality game show series 'Floor is Lava,' is a reminisce of all these things combined. The concept of it is simple and straightforward. Each level of the obstacle course is set in one of the "rooms" in the house – whether it be a basement or a dining room – and each team has to navigate these rooms by communicating with each other, jumping from one object to another, and swinging wildly from bars and nets, just in order to not get wet.
If a contestant does get wet and fall into the "lava," it's goodbye for them. The rest of their team members would have to continue finishing the level all on their own, hoping, that they can avenge them, and on the way, not face the same fate. Because once they slip and fall into the lava, they vanish. But, the question that remains is, where do they go? And what exactly happens to them after they fall? So, Let's find out.
Where Do They Go When They Fall Into The Lava?
Once a contestant slips and gets into the crimson lake, they are treated as if they are dead, and the other contestants feign horror and pretend to believe that their teammate has been permanently sucked into the void of the bubbling "lava." They do genuinely act as if the contestant has burned and perished forever. But, obviously, while we know that no one died in that hot lava, the show does not explain where the contestants go.
To be honest, even Netflix and the producers of 'Floor is Lava' have been very tight-lipped about the whole situation. They haven't revealed anything that would give us a clue about what happens to the contestants after they drop and disappear into the lava as they try to navigate the obstacle course.
However, we noticed that once a contestant does fall in, the film immediately cuts to their teammates crying in horror and showing us a replay of what happened over and over again. This cut suggests that a big chunk of footage has been edited out, and we think that the part where the contestant emerges from the lava and then exits the course is the thing that we don't get to see.
There is also a theory circling around that the contestants are pulled from below the set into another room. Well, theoretically, it is certainly possible, but practically such a maneuver is almost impossible to pull off for a simple reason that if there's any hole inside the room, it will also start emptying the lava — even if the hole opens for a few seconds. So, the best explanation of where the players go after they fall in the lava may actually lie in the clever editing of the show.
After their fall, the players are presumably taken to another room where they watch the rest of the show from the sidelines, cheering for their team to win the $10,000 grand prize and the opportunity to meet Rutledge Wood, the host of the series. They are not dead, and they are definitely not kept under the "lava" for the whole time. The mindlessly distracting series may be a little dumb, but the childlike feeling it encaptures makes it fun to watch.
Read More: What Is The Lava Made Of?


A day to enjoy throwing in porcelain with ceramic artist, Kat Logan. This course is open to all levels though some. wheel experience is helpful and the ability to center the clay. We will be focusing on learning different throwing forms, opening and closing cylinders, foot and rim treatment, altered form techniques and creating a set of related pieces.


2. Twilight also brought forth the question of would we rather fall in love with an old, (though good looking) dead person or a half-man, half-wolf (also very good looking) man. Without Twilight, we would never have thought this dilemma was a viable worry.
4. Twilight is also a beacon of hope. Stephanie Meyer showed us unpublished authors that a cheesy romance story starring a sparkly vampire can be published and sell well. REALLY well.
5. Also, we would never have seen a multitude of actors blossom and reach their full potential in their chosen career. Just look at these masterful facial expressions.
I hope this helped catch your Twilight heart and helped your love for vampires grow!


If you want you and your family to be safe, then you will need to make sure all security measures have been put in place. One of the locks which can be installed on your doors is the deadbolt locks, and they normally act as extra security for the home. The deadbolt locks are beneficial because they offer extra security when somebody tries to mess with the door or when they try to force their way in. There are certain characteristics that deadbolt locks have, and this is what makes them different. All your important things together with your family will be safe when you consider having a strong lock installed. The deadbolt lock is different from other types of locks since you will need to rotate the cylinder before you open the door. Spring-bolt locks are also common and for you to use them, then you will need to exact more force on the bolt.
It will be difficult for you to open up a door when you do not have the right key. The double cylinder, single cylinder and key less entry are some of the deadbolt locks which are in the market. There are some things which makes these locks be different from one another. There are some people who view the installation of a deadbolt lock as a difficult task and that is why they will look for the services of http://johnslocksmithservices.com/ locksmith or carpenter. However, with a bit of knowledge, you can easily install these locks. You will also need to have certain tools that will make your installation easy. First of all, you will need to evaluate your door and see if there is a hole which is there.
A majority of deadbolt locks come along with manuals that will show you where you are supposed to drill and then screw. It is important that you think about the handle of the door and where the lock will be directed to when you are installing your lock. So that you can make sure there is a proper alignment, you can use a square while attaching the template. You can also use a tape so that you cannot damage the door paint.
You can begin drilling the hole when you have found the correct location. The latch plate is the next thing that you will need to install after drilling of the holes. The next installation should be that of the strike plate, and you need to make sure that it is in line with other plates. It is now the best time to place the lock mechanism, and a majority of electronic doors have wires that can be connected on the lock and to the back. Know about deadbolt installation Philadelphia here!


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T-shirt/Stage Banner - Aaron Buchanan
T-shirt and stage backdrop commission
Commissioned to create a 'Charles Bronson' inspired character, covered in Russian prison tattoos - each telling a unique story.
I was later asked to convert the design into a 6x4 metre stage banner, extending the art deco elements.
THE MAN WITH STARS ON HIS KNEES - Album coming soon!
Stay up to date with the latest news on the band, including tour dates, new music and merchandice - and much, much more!
https://www.facebook.com/TheCultClassics/?fref=ts
First single - 'All the things you said and done' available now on itunes and Spotify.
Created Adobe Photoshop and Adobe Illustrator using a Wacom Cintiq drawing tablet.
Initial Mock Up
Stage Backdrop Banner


Glossier is one of the biggest beauty brands which is developed by Emily Weiss and by her team members and staff. Glossier is also known for providing coupons and promo codes on monthly basis in order to help by saving some money or by promoting it by offering huge sales and coupons on Glossier beauty products for students as well as for others. It offers products like Coconut Balm Dotcom, Boy Brow, Moisturizing Moon Mask and more.
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Copy the above-mentioned codes and paste that code in that coupon box. Your discount will automatically be added to your bag.


Designed for use in metal building walls and roofs, the OptiLiner® high-R system features an exceptional vapor retarder, an enhanced acoustical environment (both inside and outside of the building), and attractive finished appearance, with a bright interior finish which may allow for reduced lighting loads.
The high-R metal building insulation system uses a series of 1-inch galvanized steel straps to support a bright white or black polyethylene fabric that serves as the low permeance vapor retarder. The fabric sections are custom fit for each bay to ensure a swift installation and a clean interior finished appearance, which allows roof cavities to be completely filled with uncompressed insulation and maximizes thermal performance.
One of the difficulties in meeting code compliance for the building envelope is to prove the insulation system or application you are using meets the thermal performance (U-Value) listed for the specific code that applies to your project. This is not an issue with the OptiLiner® system since it meets the definition of Liner System (Ls) as described in the latest version of ASHRAE 90.1, which is also referenced by the IECC (International Energy Conservation Code).


Handmade French jaw clip shaped into a fancy ice cream cone in pink with three gold pearls and two white pearls on top. The unique design of this jaw clip compliments any outfit, great for all hair types. It holds securely without compromising in comfort, making styling your hair quick and easy, stylish and fabulous.


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Q: How to detect FTDI driver in system I have an app that requires FTDI D2XX Direct Drivers drivers to be installed in system. Now I am creating an installation script using Inno Setup. How can I get an information whether FTDI drivers are installed in system (Windows). Is there any path or registry entry that could be checked to gain unambiguous information about that?

A: There were two ways I was thinking of when posting this answer, but I've decided to show my preferred one that time. For the sake of completeness, I'm including also a generic way to check whether a library is present in the system.
1. Try to call an FTDI driver library function
I think the best you can do is trying to call a function from the driver's library itself using delayed loading (delayload option). A good function to call is e.g. the FT_GetLibraryVersion function, by which you can get the library version, and which does not require opened device. In the following example code is shown just how to test whether the library is present in the system:
[Code]
type
  ULONG = Cardinal;
  FT_STATUS = ULONG;

function FT_GetLibraryVersion(out lpdwVersion: DWORD): FT_STATUS;
  external 'FT_GetLibraryVersion@ftd2xx.dll stdcall delayload';

function IsFTD2xxInstalled: Boolean;
var
  Version: DWORD;
begin
  Result := True;
  try
    FT_GetLibraryVersion(Version);
  except
    Result := False;
  end;
end;

It's just a probe if a library function can be called. Hence there is no result nor error checking.
2. Check the library presence in a generic way
Since the functions like LoadDLL and FreeDLL are deprecated (and there's no function to check if the library is already loaded), a generic way for checking whether a library is present in the system requires importing a few WinAPI functions. The following function LibraryExists checks whether a library of a given name is already loaded by Inno Setup and if not, it tries to load and unload it:
[Code]
#ifdef UNICODE
  #define AW "W"
#else
  #define AW "A"
#endif

const
  ERROR_MOD_NOT_FOUND = 126;

type
  HINSTANCE = THandle;
  HMODULE = HINSTANCE;

function LoadLibrary(lpLibFileName: string): HMODULE;
  external 'LoadLibrary{#AW}@kernel32.dll stdcall';
function FreeLibrary(hLibModule: HMODULE): BOOL;
  external 'FreeLibrary@kernel32.dll stdcall';
function GetModuleHandle(lpModuleName: string): HMODULE;
  external 'GetModuleHandle{#AW}@kernel32.dll stdcall';

procedure RaiseLastError(const Message: string; const Exclude: array of LongInt);
var
  I: Integer;
  LastError: LongInt;
begin
  LastError := DLLGetLastError;
  for I := 0 to GetArrayLength(Exclude) - 1 do
    if Exclude[I] = LastError then
      Exit;
  RaiseException(Format('%s' + #13#10 + '%d: %s', [Message, LastError,
    SysErrorMessage(LastError)]));
end;

function IsModuleLoaded(const Name: string): Boolean;
begin
  Result := GetModuleHandle(Name) <> 0;
  if not Result then
    RaiseLastError('GetModuleHandle call failed.', [ERROR_MOD_NOT_FOUND]);
end;

function LibraryExists(const Name: string): Boolean;
var
  Handle: HMODULE;
begin
  Result := IsModuleLoaded(Name);
  if not Result then
  begin
    Handle := LoadLibrary(Name);
    if Handle <> 0 then
    begin
      Result := True;
      FreeLibrary(Handle);
    end
    else
      RaiseLastError('LoadLibrary call failed.', [ERROR_MOD_NOT_FOUND]);
  end;
end;

And a possible usage for your case:
function IsFTD2xxInstalled: Boolean;
begin
  Result := LibraryExists('ftd2xx.dll');
end;

redpajama_set_name: RedPajamaStackExchange


Tanah Lot Tour or known as Tanah Lot Sunset Tour is one of the Bali half day tour packages to go to the temple in the sea that is popular with the magical sunset background.
Tanah Lot temple excursion spends up to 5 hours to explore the places of interest in the southwest of Bali island and the trip will end up in Tanah Lot Temple to experience the lovely panorama of the sea temple that stands on a hard rock with a fabulous view of the sunset backdrop.
Tanah Lot Bali is one among the greatest destinations on the island of Bali Indonesia and it is a must-place to visit when you are on holiday in Bali.
Tanah Lot Temple Bali Tour is a hit choice among most of the Bali tour packages, which really can be proved by a massive tourists are coming to visit the temple every day.
Below is the itinerary of Bali temple Tanah Lot sunset tour package in a half day around 5 hours to 6 hours, please be informed that the Tanah Lot tour package from us is a private tour with a private vehicle (NOT a sharing tour) and you will be accompanied by a friendly and professional driver.
The first place to visit in the itinerary Tanah Lot Tour Package is Taman Ayun Temple that is located in the region of Mengwi, Badung regency, Bali.
Pura Taman Ayun Temple is a Mother temple to the Mengwi Kingdom. This temple was built by King Mengwi, I Gusti Agung Putu, in 1556 Saka (1634 AD).
Taman Ayun Temple surrounded by the large water ponds and also has a beautiful garden around it. It's one of the sites in Bali defined by UNESCO as world cultural heritage in 2012.
Taman Ayun Temple is the supreme water temple with its most typical architecture, exemplifies the complete development of the Subak irrigation method under royal authorities of Bali in the 19th century.
The entrance fee to visit Taman Ayun temple is IDR 20,000/person (Valid for 2018, the entrance ticket may change without any prior notice).
The second attraction to visit in the Tanah Lot Temple tour is Alas Kedaton Monkey Forest, it is located in the village of Kukuh, Marga Sub-district, Tabanan Regency, Bali.
Alas Kedaton Monkey Forest is one the most popular sacred monkey forests in Bali island. The forest covers 6.4 hectares inhabited by monkeys and also big bats.
Apart from that, there is also a temple which is located in the middle of the Kedaton forest. The Alas Kedaton temple was built by Mpu Kuturan during the reign of King Sri Masula Masuli in Bali around 1178 AD - 1255 AD.
The entrance fee to visit Alas Kedaton Monkey Forest is IDR 15,000/person (Valid for 2018, the entrance ticket may change without any prior notice).
The final destination to go in the Tanah Lot Sunset tour package is to visit Tanah Lot Temple, it is located at Beraban village, Kediri subdistrict, Tabanan regency, on the south coast of the island of Bali Indonesia, more or less 25 km from Denpasar city.
Tanah Lot is a Hindu temple built to worship the God in its manifestation as the God of the sea (Lord Varuna) to invoke prosperity and the balance of sea and earth.
Tanah Lot Temple was built by Danghyang Nirartha (Holy priest from Java island) in 16th Century, people also call him DangHyang Dwijendra or Pedanda Sakti Wawu Rauh.
Tanah Lot is a very famous tourist destination in the world and it's one of the best attractions in Bali island, the sunset time at Tanah Lot becomes the sweetest moment that can be enjoyed when visiting this temple.
The entrance fee to visit Tanah Lot is IDR 60,000/person (Valid for 2018, the entrance ticket may change without any prior notice).
The tour will end here, and we'll go back to the hotel after sunset.


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Труп () — мертве тіло людини чи тварини

Труп — місто, штат Нью-Йорк
 Труп — місто, штат Пенсільванія

redpajama_set_name: RedPajamaWikipedia


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Investors pile into gold
Slice 1
The gold price is poised to hit an all-time high, amid growing expectations that the Federal Reserve will put a cap on US interest rates to stimulate its economy.
This week, the price traded at $1,800 an ounce, against a record $1,896 struck in September 2011. It was $1,290, on 2 May 2019, when Family Capital pointed to purchases by the central banks as a bullish indicator.
The central banks have remained net buyers ever since although they fell in number in the first quarter. The Russian central bank said it would suspend its gold purchases in April, possibly due to a drop in oil revenues.
Gold purchases by investors have been behind a price rise of 17% this year, amid the Covid-19 pandemic, against a -5.5% loss for US stocks. In value terms, gold-backed ETFs rose in value by a record $23 billion in the quarter.
Hedge fund manager John Paulson has benefited hugely, as one of the world's biggest investors in gold and mining stocks since the 2008 credit crisis. Paulson has just confirmed that he will convert his $9 billion hedge fund into a family office.
The gold price is buoyant when low yields offer little incentive for investors to put their money in bonds or bank accounts. Gold also benefits during periods of low-interest rates when inflation expectations are rising and the dollar is falling.
More than half of economists recently polled by Bloomberg say the US Federal Reserve will keep a tight lid on bond returns through a measure known as yield curve control.
This strategy would see the Fed using bond purchases to cap yields on certain maturities at a specific level.
This move was initiated by the Bank of Japan four years ago, as it fought to free its economy from a 20-year deflationary spiral.
Australia adopted its own version of the policy this year. Traders say India has adopted the strategy informally.
A recent fall in yields for five and ten-year Treasury bonds suggests the market is bracing itself for the yield control. Fresh Covid-19 outbreaks in part of the US, plus corporate collapses, have helped fuel this expectation although some argue the recent economic recovery has been sharp enough to postpone the strategy.
Analysts believe that yield curve control could spark a "buy everything" rally for credit, equities, gold and emerging markets, although gold is perceived as a prime beneficiary.
This would be due to dollar weakness and economic uncertainty hurting the other asset classes.
Goldman Sachs has raised its gold price forecast to $2,000 an ounce saying consumers in emerging markets could afford to lift purchases, if the dollar stays low. Bank of America is forecasting gold hitting $3000 an ounce.
Thomas Puppendahl, founder of Singapore-based Chancery Asset Management, says gold will hit $5,000 as inflation rises: "Gold needed a black swan event to launch the next bull market.
Everything has come together now. We are seeing governments going in hyper overdrive and printing even more money and central banks calling on governments to implement fiscal stimulus."


I've always found the BD message boards to be a good barometer of what's happening on the So Cal fishing scene. I don't gauge it by the reports that are, or aren't, being posted, but on the amount of non-fishing related posts I see — especially those that flare into 10-page monster arguments on subjects like tipping on sport boats. While these types of threads are amusing, they're usually a pretty good indicator that our members are getting restless due to a lack of fishing.
While we've got some rain scheduled to arrive this weekend, the last couple weekends have offered great weather and while the fishing hasn't been wide open, there were still plenty of fishing options available to both private and sport boat anglers.
If you're feeling like getting off the couch and out on the water, this is a great time of year to learn new techniques and practice some of the things you already know. That way, when the fish do start biting again, you'll be better prepared to catch them. Everyone's fishing goals and skill sets are different, so I can't tell you what you should be practicing or experimenting with, but I will share what I've been doing over the last few weeks, and it might just give you some ideas of your own.
Though seemingly abundant and easy to catch, spotted bay bass have proven to be the nemesis of me and my fishing partner Matt. These fish, which can be so easy to catch on some days, prove almost impossible for us to catch on tournament day. While we've had some success, like our fifth place finish in an SWBA spotty event a couple of years ago, we just can't ever seem to get the fishery dialed in to the level that we can when targeting sand bass or calicos.
I believe this is mostly due to the fact that we need to stop thinking like saltwater bass fishermen and start acting like freshwater bass fishermen as some of the best spotty fishermen on the tournament circuit have extensive largemouth bass fishing experience. The problem is that it's tough to just throw a switch and start fishing differently. Like anything else, it takes hours and hours of practice. So, that's why I've been trying to commit at least one trip per week this winter to targeting spotties. Yeah the fishing's been tough more often than not, but that just makes it more rewarding when I do catch a few.
A couple of weeks ago I went fishing with my friend Dave Valadez who invited me to come and check out how he fly-fishes for calico bass. With morning air temps hovering just about freezing along the coast and brisk 52-degree water on the Palos Verdes coast, I didn't have very high expectations. To my surprise, the fish were biting the fly pretty well and they were doing it in areas that I'd never had much success with conventional baits.
So, not only did I get a chance to learn about a new technique, I also got to see how different presentations might lead to bites, or lack of bites, at a particular spot. While the information I gathered may not be of any immediate use, it's important to hang on to it rather than dismiss it. Any information gained on the water is of value if you can process it and log it into your memory for future use.
This may seem like a minor factor, but it's the single most important step in becoming a better fisherman. An angler can only reach a certain level of ability when casting. By that I mean that just about all really good fishermen are on the same level when it comes to handling a rod and reel, casting and presenting a bait. So aside from that, the only thing that sets one fisherman apart from the next is his ability to process and log the information he takes in.
It's a lot like assembling a picture puzzle. In the beginning, there is a big, mixed up pile of pieces and a picture on the box that shows what the end result should look like. At that point it might seem damn near impossible that you'll be able to assemble all of the pieces in the correct manner. But if you follow procedure and pick out all of the pieces that are flat on one side and put the frame together, it starts to look a little more manageable.
The next step is to work on the easily distinguished parts of the puzzle and then put those into their approximate position to give you a better feel for the whole picture. At this point you've probably got 80 percent of the puzzle finished, but now that all the obvious things are completed, it will take an ability to focus on the small details to fit together the remainder of the puzzle.
A lot of fishermen are content to get 80 percent of the puzzle completed and call it good, which is okay. I was one of those guys too and to be honest I didn't even realize that there was another 20 percent of the puzzle that was still awaiting completion.


An easy way to give PGDB (PostgreSQL) a performance boost is to judiciously use indexes based on queries observed in the system. For most situations, this is as simple as indexing columns that are referenced frequently in WHERE clauses. PGDB is one of the few database engines that takes this idea even further with partial indexes. Unfortunately as a consequence of insufficient exposure, most DBAs and users are unfamiliar with this extremely powerful functionality.
Imagine we have an order system that tracks order state, such that entries are marked as new, processing, or done. These kinds of transient states are not uncommon in various inventory management systems, so it's a great example for this use case. Often with such systems, data is distributed in such a way that more than 90% of orders are marked as 'done'. To make this interesting, let's just cap the done state at 90%, and distribute another 5% to processing, and 5% to new.
In many, if not most situations, automated tools and interfaces are only interested in pending order states. If an order is new, or in the middle of processing, it's going to see a lot of activity. Because of this, a lot of queries will request orders based on status. Let's presume an example of this is to fetch all new orders from a certain account, possibly for display on a web site.
In my virtual environment, this executes in about 3ms and uses the index on account_id as expected. Few people would consider a 3ms execution time as slow, so this is where most optimization stops. But we know something about this data! We know that 90% (or more) of all possible order states are 'D'. In the case of this query, PGDB has to reduce 10,000 matches from the index, down to 500 to return our results.
Hopefully it comes as no surprise that an index which includes 90% less data will be 90% smaller. Also, keep in mind that this contrived example was designed to somewhat downplay the effect of partial indexes. In a real order system, far more than 90% of orders would be marked as done, thus magnifying the speed increase and index size reduction.
There are a lot of ways partial indexes can be used, and like most tools, they're not appropriate for all situations. But when the data cooperates, they're extremely relevant. When time permits, take a look at data distribution and queries against the system. Chances are, there will be at least one situation that could be improved with a partial index.
If only every database was so accommodating.
There is any recommendation about when to repeat the where clause of the index in the where clause of the query. I read that sometimes is needed to convince the planner to use the index.
BTW, this is a great serie of posts. Thanks for taking time to write it. As a developer that sometimes have to do DBA tasks there are very helpful.


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26 Oct 2020 3:08 PM +00:00 UTC
NBA 2K21: Top earning title in September 2020
2K had a September to remember with the launch of NBA 2K21.
By Toby Durant
NBA 2K21 dropped on 4 September, and had a truly remarkable launch month.
While 2K has spent plenty of time recently hyping up the amazing features the next-gen version will have, gamers have been enjoying the title on current-gen too.
Top earner for September
NBA 2K games sell like hotcakes every year, and 2020 was no different.
NBA 2K21 sold 1.9 million digital units, with digital console sales up 19% over NBA 2K20 at launch.
NO STOPPING ME: New physics will make driving the rim even more realistic
in-game revenue has seen an increase too, of 8% over last year.
All told that made NBA 2K21 the top earning title of September per a SuperData report.
NEXT-GEN: NBA 2K21 looks better than ever
Some of this is attributed to the NBA playoffs running at the same time, heightening the interest in the sport and the game.
Plans for next-gen
NBA 2K21 promised something big for next-gen, and 2K has started to outline what that means. From new player ratings to changes in Badges and new Takeovers, there is a lot of new gameplay options for players to enjoy on PS5 and Xbox Series X.
SPLASH DOWN: The Warriors are still elite in 2K21
All that comes with the natural upgrades the superior hardware offers, like faster loading and better graphics.
NBA 2K21 is the first truly next-gen built sports title, and we can't wait to see how it plays on the new machines!