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Malaysia Airlines launches new brand following fatal incidents last year
The company is rebranding to Malaysia Airlines Berhad (MAB) after it saw a £54.2 million loss in 2014 following a plane disappearing and another being shot down over Ukraine.
By Sarah Dawood September 1, 2015 4:44 pm September 1, 2015 4:44 pm
Image courtesy of Flickr user Byeangel.
Malaysia Airlines, which saw two fatal incidents last year, is rebranding with new name Malaysia Airlines Berhad (MAB).
The airline announced last week that it had received its Air Operator Certificate from Malaysia's Ministry of Transport to fly under the new name, with flights starting today 1 September.
The airline announced that it would rebrand in June this year, after it saw one plane disappear and another shot down in 2014.
"Milestone" for the airline
Datuk Seri Liow Tiong Law, Malaysian minister of transport, says: "This is an important milestone in the evolution of Malaysia's national airline.
"The government of Malaysia is committed to ensuring that the rejuvenated Malaysia Airlines will take off on a strong note."
MAB had to undergo months of audit activities before qualifying for its AOC, including airworthiness of the airline's operations and aircraft maintenance.
Aims to become "national icon"
The new MAB visual identity is yet to be revealed. The airline's chairman Tan Sri Md Nor Yusof says: "MAB will endeavour to ensure our passengers are given the best of our services and we will persevere to build a sustainable national icon."
The company was announced "technically bankrupt" in June this year, after it saw a £54.2 million loss between March and June of 2014. This was following flight MH370 going missing in March 2014, and flight MH17 being shot down over Ukraine in July 2014.
31 August-6 September 2015 Projects Branding
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UBS reveals new branding (and new sound…)


Do you have nerve damage? Nerve damage can result from a variety of causes: traumatic injuries, exposure to toxins, infections, metabolic problems, and even inherited causes.
Oftentimes, it's more than just an inconvenience. You could be experiencing stabbing pain in the middle of the night. Or you might be feeling prickling, tingling, or burning all day long. This can make sleeping a challenge, and doing even simple daily tasks can be a major chore.
Fortunately, surgical intervention can help repair damaged nerves. And at Coastal Empire Orthopedics, Dr. Jonathan Shults is an experienced orthopedic surgeon who can help you decide if surgery is the best option for you.
Autonomic nerves control heart rate, blood pressure, digestion, and body temperature. If this is the type of nerve damage you're suffering from, you may experience the inability to sense chest pain, excessive sweating, lightheadedness, dry eyes and mouth, constipation, and bladder and sexual dysfunction.
Motor nerves control movement and actions. You may experience weakness, twitching, paralysis, or muscle atrophy if you have motor nerve damage.
Sensory nerves are what allow your skin and muscles to send information to your spinal cord and brain. If you have sensory nerve damage, you may experience sensitivity, numbness, tingling, prickling, burning, pain, or problems with positional awareness.
Nerve damage can negatively affect the quality of your life and can be an ongoing issue if not treated.
Are you a candidate for nerve surgery?
Consult with your physician before trying any of these management treatments.
If you have a closed nerve injury and clinical treatments and electrodiagnostic studies don't work after three months, surgery is generally recommended.
If you have an open nerve injury, Dr. Shults generally recommends surgery immediately.
With a crushed nerve injury, as with a closed nerve injury, surgery is often recommended if you don't improve after after three months of more conservative treatments.
The exact process for surgery can vary depending on the cause and the location of the pain. There are many cases where the pain comes from pressure on a nerve or several nerves. When this pressure is removed, oftentimes the pain also goes with it.
Depending on your condition, small incisions can help remove the pressure on the nerves. In other cases, the nerves need to be divided and rerouted.
Sometimes, the procedure leaves you with numbness, but many patients find this to be a better option than living with the pain.
Is your nerve damage negatively affecting your daily life? Have you explored other options only to find no relief? Surgical intervention can help repair your damaged nerves, allowing you to live more comfortably. Is surgery right for you? The only way to know is to get in touch with us at Coastal Empire Orthopedics. Don't delay — call today or book a consultation using our online portal.
Knee pain affects people of all ages. From teens to seniors, knee pain can make it hard to enjoy the activities you love. Learn more about your knee pain — and what you might be doing to make it worse.
Do you suffer from chronic joint pain? Many Americans today face limitations on their physical activities due to joint pain. Read on to learn how stem cell therapy can help relieve the pain.
Trigger finger is a condition where your finger locks up or sticks in a flexed position, making it difficult for you to straighten it, then snaps straight. There are treatment options to help you find relief from this condition.
How Effective is Carpal Tunnel Surgery?
Carpal tunnel syndrome is a painful condition that makes everyday activities hard to enjoy. But is carpal tunnel surgery worth it? Learn more about the relief you can find with carpal tunnel surgery and get back to work or the activities you love.
Weekend warriors may catch up on much-needed exercise after the work week is over, but they also put themselves at risk of injury. Learn about the most common injuries and how to avoid them.
Overuse injuries aren't just common in adults, they also affect young athletes. The good news is many overuse injuries can be prevented with proper technique and training. Read on for the signs of overuse injuries and ways to keep your child healthy.


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Home > Blog > Shopify Celebrates 5 Years on HackerOne
Shopify Celebrates 5 Years on HackerOne
May 5, 2020 | HackerOne
Five years ago, Shopify's small but mighty security team began their hacker-powered security journey with HackerOne. Since then, they have paid out over $1,000,000 in bounties and resolved more than 1,150 vulnerabilities thanks to hackers.
Early on, the Shopify security team realized the significant impact white hat hackers could have in strengthening security. What started in 2013 as a self-run, email-based bug bounty program with a security team of one, has now become a fully-fledged public program with a Trust and Security team of more than 100.
To celebrate this milestone, we sat down with Pete Yaworski, Senior Application Security Engineer at Shopify to learn about their program's top hackers, biggest lessons learned, and what's ahead.
"Security is not a one-time thing, but a continuous cycle. We know that there are always going to be bugs in software development," said Pete Yaworski, Senior Application Security Engineer at Shopify. "As we develop, and as we iterate, we want to make sure security is an active part of that process, and never a roadblock to innovation. The HackerOne bug bounty program allows us to put another cog in the wheel of security."
Last year, Shopify became the 5th public bug bounty program on the HackerOne platform to reach the $1,000,000 paid in bounties milestone. Along the way, they had help from 400+ unique hackers across 60+ countries. To date, they have resolved over 1,150 vulnerabilities, with the highest bounty being $25,000.
Shopify continues to attract new hackers to their program with their comprehensive scope and commitment to transparency. Shopify has been a big proponent of disclosing resolved vulnerabilities on Hacktivity. In the past 5 years, they have publicly disclosed over 450 reports for other security teams and hackers to learn from.
"Transparency is an overall net win for the broader community, and we would love to see disclosures standardized within the security community," said Pete. "Not only are they helpful for other programs and hackers to learn from, but they act as a flag for hackers to follow-up on, to test tour fixes for bypasses. We've received vulnerability reports that would not have been found had we not disclosed a previous bug."
In addition to their dedication to transparency, they have also achieved record-breaking response times. They aim to pay out eligible bounties within seven days of triage, and have an average first response time of ten hours!
TAPPING INTO THE HACKER MINDSET
The hacker community is always at the forefront of the Shopify program and they've built relationships through live hacking events and engagements through reports. In fact, in 2017, Shopify hired Pete Yaworski, also known as @yaworsk and one of the top hackers on HackerOne, for an in-house role on their security team, after establishing a relationship at the 2017 h1-415 live hacking event. Keeping with the company culture, the program is truly designed by hackers for hackers.
"Don't underestimate the creativity of hackers. Everyone comes at it with a different lens, different expertise, and different experience," shares Pete. "We don't want to leverage the community to approach a problem in the same way we would approach a problem. Our software becomes more secure when we open it up to diverse mindsets."
Pete and the Shopify team have noticed a few standout contributors to the program over the last 5 years, who all bring diverse skills sets to the table:
@h13- has become the number one hacker on Shopify's program and the team has enjoyed watching his skills evolve, and his attention to detail grow. His ability to dive into new functionality as it's been released has been impressive and unmatched.
@zombiehelp54 has been hacking on Shopify for a long time and is one of a few hackers to have been awarded swag for his critical reports. His persistence poking at a problem until confirming a vulnerability is enviable.
@cache-money's ability to think creatively has impressed the team. You can tell he has a software development background with the way he approaches hacking.
@0xacb has taken the largest bounty we've ever awarded. He invests his time when approaching a program and digs deep when he smells a vulnerability, which results in very impactful bugs.
@ngalog is newer on the program but has shown great potential and a willingness to help teach others. We hope sticks with us and continues his commitment to disclosing bugs for others to learn from.
"We don't see reports as a one-time interaction, but as a single step in a long term relationship with our hackers," said Pete. "We respect their time and are proactively working to ensure we create a positive experience for them. It's a big win when they take the time to poke at our systems."
LEARNINGS AND LOOKING TO THE NEXT 5 YEARS
Of course, running a bug bounty program for half a decade brings much experience and learnings to share.
First, Shopify tends to view hackers as a resource to cherish. One that provides much more value than just reporting bugs. It's the hacker mindset, specifically their tactics and methods that can't be easily replicated, no matter how robust an internal security effort might be.
Second, Shopify sees hacker-powered security as a means of broad and non-stop testing far beyond what any internal security team alone could accomplish. That blanket of coverage extends downstream into engineering and development, which adds another "guardrail" on the software development lifecycle.
Finally, Shopify points to transparency as beneficial to everyone, from their internal teams, to other hackers, to other bug bounty programs, and even to the technology industry in general. Specifically with disclosures, their belief is that the more everyone shares, the safer everyone will be.
As Shopify's public bug bounty program moves into its next year, the team continues its goal to improve response times, strengthen its partnership with the hacker community and continue as a top program on HackerOne. This includes finding new ways to attract hackers to the program through competitive bounties, impactful scopes and innovative means of communication.
To learn more about Shopify's bug bounty program, visit their program page at https://hackerone.com/shopify
January 13 | HackerOne
LINE on Securing the Application Development Lifecycle with Bug Bounties
December 17 | HackerOne
Grab Celebrates 5 Years on HackerOne
Quantifying Risk: How do you measure success in security?

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Joe Dante Could Have Directed A Batman Movie With John Lithgow As The Joker
Posted on Wednesday, September 14th, 2016 by Jacob Hall
Tim Burton's Batman shook the pop culture landscape in some pretty profound ways when it first arrived back in 1989. Burton transformed into a go-to blockbuster guy. Michael Keaton proved himself to be more than just a comedian. Jack Nicholson became absurdly wealthy. And perhaps most importantly, millions of people around the world willingly paid hard-earned cash money to see a superhero movie, which wasn't exactly a healthy genre at the time.
But that version of the film only came about after nearly a decade of development, with many different directors, writers, and actors brushing against the project. One of those directors was Joe Dante, and he wanted to cast John Lithgow as the Joker.
Dante is, of course, the director B-movie gems like 1978's Piranha and 1981's The Howling, but it was 1984's Gremlins that put him into proximity with the Dark Knight. At the time, Warner Bros. was working from a screenplay by Tom Mankiewicz (who did uncredited work on Richard Donner's Superman movies), and it was very different form the version that would come together several years later. Speaking with Psychotronic Cinema, Dante explained that he wanted to cast Lithgow as the Joker, but it was this character that also led him to drop the film:
I wanted to hire John Lithgow for that part [of the Joker] because I had met him on The Twilight Zone movie. And for whatever reason, I started to gravitate more towards The Joker than towards Batman. And I actually woke up one night and I said to myself, 'I can't do this movie—I'm more interested in The Joker than I am in Batman, and that's not the way it should be.' I think I was not the right guy to do the movie.
Interestingly, Tim Burton's Batman is also more interested in the Joker than it is in the Caped Crusader himself. It just seems like that wasn't as much of concern for Burton.
At this time, Lithgow was a two-time Oscar nominee for The World According to Garp and Terms of Endearment, so it's not like he was small potatoes (although he definitely lacked the star power of Jack Nicholson). In retrospect, it's easy to imagine Lithgow killing it with this role. He's an incredible comic presence who could have captured the playful side of Batman's arch-nemesis, but his terrifying work in the fourth season of Dexter is proof that he could have given us a villain worthy of nightmares. As far as "What Could Have Been" casting stories go, this is a great one.
Thirty years later, Dante doesn't sound too beat up about never making this movie:
I don't regret not doing Batman, in the sense that I'm not sure what it would have ended up being like. But I certainly can't say it was a major career-booster, my decision not to make it.
Anyway, Dante is a tremendous raconteur and the entire interview linked above is worth your time if you enjoy good things.
Superhero Bits: 'Batwoman' Crossovers with 'Supergirl' and 'Superman & Lois' Canceled, 'X-Men' Arcade1Up Cabinet & More
Cool Stuff: Bottleneck Gallery's New Batman Posters Honor 'Batman Returns', 'The Dark Knight' & More
Superhero Bits: 'Rise of the TMNT: The Movie' Synopsis Revealed, Wolverine Casting Rumors Debunked & More
Superhero Bits: Black Mask Heading to 'Batwoman', Martian Manhunter Confirmed for Zack Snyder's 'Justice League' & More
Comic Book/Superhero, Trivia, Warner Brothers, Batman, Joe-Dante, Jon Lithgow


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Castle Orthopaedics is now open for virtual and face to face appointments at both Spire Nottingham Hospital and BMI The Park Hospital. We are also now scheduling treatment and surgery.
Contact UsMake a referral01156 719930contact@castleortho.co.uk
Castle Orthopaedics
Degenerative arthritis
Meniscal injuries
Subacrominal impingement
ACJ pain & injuries
Tennis / golfer's elbow
Deformity of foot & toes
Dupuytrens disease
Rotator Cuff Injuries are Common with Summer Sports
Elbow & Shoulder
Rotator Cuff Injuries are Common…
Your rotator cuff is a group of muscles and tendons surrounding the shoulder. They help to provide stability and keep the head of your upper arm within your shoulder socket, as well as enabling your arm to rotate. Rotator cuff injuries are common in sports that involve making repeated overhead movements, as well as certain professions like carpentry or painting and decorating.
Symptoms of rotator cuff injuries
A torn rotator cuff causes a sudden and severe pain at the top and side of your shoulder if it the result of a single injury. Alternatively, microtearing may develop over time as the result of repetitive movements and this tends to cause a deep ache within your shoulder, sometimes accompanied by arm weakness. If you have a torn rotator cuff, it may be difficult to reach behind your back or comb your hair and the pain may worsen when you have your arm raised. Some people find it uncomfortable to sleep. The rotator cuff may become fully or partially torn.
Summer is a peak time for us to see people with rotator cuff injuries due to an increase in people playing sport. The rotator cuff is particularly prone to tearing in people over the age of 40 who play high impact sports. This is because the tendons degenerate naturally with age. A weakened rotator cuff may tear suddenly and completely in older sportsmen and women so it is important for people in this age group to warm up properly before a game and to train with a professional coach to ensure that they are using correct technique. A physiotherapist can recommend low resistance exercises to strengthen your rotator cuff, which is particularly important if you have had a previous injury.
Other factors that increase your risk of rotator cuff injury include having a job that necessitates making repetitive overhead arm movements and have a genetic predisposition.
High risk sports
Tennis players are one of the groups most at risk of rotator cuff injuries due to the strain placed on this group of muscles during the tennis serve. If you play tennis regularly you may develop microtears or partial tears in the rotator cuff due to the jarring caused by hitting the ball repeatedly. This is called tendinopathy and it can lead to subacromial bursitis, which causes pain in the upper arm which may be worse at night.
Golfers are also at risk of rotator cuff tears due to the strain placed on the shoulders, arms, back and wrists during the golf swing. Other sports that can cause rotator cuff tears include volleyball, basketball, swimming and weightlifting.
Diagnosis of rotator cuff injuries
A torn rotator cuff may cause degeneration of the shoulder joint if it is not treated so it is essential to get a proper diagnosis. Your doctor will carry out a physical examination and assess the strength of your shoulder and arm muscles. You may be sent for imaging tests such as an X-ray to rule out other causes of shoulder pain (for example, arthritis), or an ultrasound scan to assess the structures of your shoulder as you move. MRI scans are also sometimes used.
Treatment of rotator cuff injuries
Treatment for a rotator cuff injury depends on the severity of the tear. Your orthopaedic surgeon will always recommend conservative treatments first. If you suspect you may have a rotator cuff injury, rest the affected shoulder and use ice to bring down swelling. A physiotherapist may be able to recommend exercises to strengthen your shoulder and carefully restore flexibility.
If conservative treatments don't alleviate the symptoms you may be offered:
Injections of steroids into the affected shoulder joint.
Tendon repair – This may be performed arthroscopically (using keyhole surgery) using a small incision and tiny instruments to reattach the torn tendons to the bone. However, some rotator cuff tears are more suitable for open surgery, using a larger incision to access the damaged tendons.
Tendon transfer – If the tendons cannot be repaired it may be better to use a nearby tendon to replace the damaged one.
Shoulder replacement – In very severe rotator cuff injuries, a shoulder replacement may be the only option. In some cases, a reverse shoulder arthroplasty (where the artificial joint has a socket on the arm bone and a ball on the shoulder blade rather than the other way around) may be the best way to ensure joint stability.
Pain in your shoulder that lasts beyond a few days needs to be investigated by a doctor to ensure that it is appropriately treated and to avoid the risk of long-term damage.
Castle Orthopaedics is here to help
Following the lockdown, Castle Orthopaedics is now re-open for virtual and face to face appointments at both Spire Nottingham Hospital and BMI The Park Hospital. Surgery is now also being scheduled once again, which means that injuries requiring surgery can be treated.
Our orthopaedic consultants each specialise in a particular area of orthopaedics, giving you added peace of mind that you are receiving expert medical advice and highly tailored treatment.
BMI The Park Hospital
Sherwood Lodge Drive Burntstump Country Park, Arnold NG5 8RX
Spire Nottingham Hospital
Tollerton Ln, Tollerton, Nottingham NG12 4GA
Meet our specialists >
Fees >
Categories: Elbow & Shoulder, Orthopaedic Treatment 12th August 2020
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Managing Your Arthritis in 2021
Arthritis: The Importance of Staying Healthy and Mobile in Winter
Rugby Injuries: Prevention, Diagnosis and Treatment
Stress Fractures of the Foot and Ankle: Who Is At Risk and How to Prevent Them?
Frozen Shoulder: Causes, Symptoms and What To Do
Is Private Joint Replacement Surgery a Worthwhile Option Right Now?
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C&M takes alot of pride in helping those that are unfortunate. Ten years ago, C&M Home Heating Oil partnered up with Joe's Oil and the District of Columbia (LIHEAP) Program. Their purpose in doing so is to provide affordable home heating oil during winter months to families in need.
C&M is also big on giving back to young Men and Women of their community by donating to local Schools such as: Robert Frost Elementary, Charles Carroll Middle School, Parkdale High School, Duval High School, Central High School, Potomac High School, Fairmont Heights High School, Charles Herbert Flowers High School, Eleanor Roosevelt High School just to name a few.
The promotion of biodiesel enhances the State's energy security and air quality initiatives that aid in the reduction of global warming. These our primary goals are embeded in our Motto, which is "Let our family heat your family".
If any questions arise as you surf through our site or if we can be of service to you, please feel free to call us at 301-336-0065 or C & M Contact Form. We look forward to providing you with our products and services.


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Facelifted 2014 Honda CR-V Series II revealed
03 Dec 2014 Isaac Bober
Honda has revealed its facelifted 2014 Honda CR-V Series II featuring a range of upgrades to two and all-wheel drive variants, and no price change.
HONDA HAS revealed its "redesigned inside and out" 2014 Honda CR-V Series II. And, according to Honda Australia director, Stephen Collins: "The most significant change to the two-wheel drive range is the addition of two variants. The two-wheel drive variants also have the same spec levels as their four-wheel drive counterparts; what differentiates them is drivetrain.
"Spec levels are outstanding and we've kept the same sharp, competitive price, demonstrating our commitment to great value for money."
Key exterior changes see the addition of LED daytime running lights, a new griller and new front and rear bumper design as well as a new colour; Brilliant Sporty Blue Metallic. Inside, the changes are limited to paino-black trim and chrome surrounds to HVAC vents.
Honda has grown the variants available, with buyers now able to choose from three two-wheel drive variants: VTi (from $27,490+ORC – manual; from $29,790+ORC), VTi-S (from $33,290+ORC) and VTi-L (from $36,290+ORC). Both the petrol and diesel VTi receive Honda's Display Audio system with Bluetooth connectivity and audio streaming along with one HDMI and two USB ports. The reversing camera has also been upgraded to feature three modes: top-down, wide and normal.
The VTi-S variants in both drivetrains (petrol and diesel) receive Smart Entry with push-button start, auto wipers, auto headlights, front and rear sensors, dual-zone climate control and Honda's LaneWatch system that features an integrated camera offering an 80-degree view of the left lane of traffic to aid the driver in monitoring a blind spot.
Both VTi-L drivetrains feature Display Audio Plus with inbuilt satellite navigation and leather-appointed trim. The four-wheel drive VTi-L's factory-fitted Advanced Driver Assist System (ADAS) which includes Collision Mitigating Braking System (CMBS), Active Cruise Control (ACC) and Lane Keep Assist System (LKAS) has also been retained (it's available from from $42,290+ORC).
Tags:Honda CR-V
Kia Seltos S vs Honda HR-V VTi
The difference between a 65 and 90km/h crash
Honda CR-V range updated for 2021
Honda CR-V Vi 2019 Review


hi i would like to get the current coordinate of the user on the mapview.
My question is how do i get the x and y coordinate in NSString instead of AGSPoint or AGSGeometry?
Is there another way to get the current coordinate?
Hi i manage to solve my own problem.


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c) Accompany it with the information you received as to the offer to distribute corresponding source
code. (This alternative is allowed only for noncommercial distribution and only if you received the
program in object code or executable form with such an offer, in accord with Subsection b above.)
The source code for a work means the preferred form of the work for making modifications to it. For
an executable work, complete source code means all the source code for all modules it contains, plus
any associated interface definition files, plus the scripts used to control compilation and installation of the
executable. However, as a special exception, the source code distributed need not include anything that
is normally distributed (in either source or binary form) with the major components (compiler, kernel, and
so on) of the operating system on which the executable runs, unless that component itself accompanies
the executable.
If distribution of executable or object code is made by offering access to copy from a designated
place, then offering equivalent access to copy the source code from the same place counts as
distribution of the source code, even though third parties are not compelled to copy the source along with
the object code.
4. You may not copy, modify, sublicense, or distribute the Program except as expressly provided
under this License. Any attempt otherwise to copy, modify, sublicense or distribute the Program is void,
and will automatically terminate your rights under this License. However, parties who have received
copies, or rights, from you under this License will not have their licenses terminated so long as such
parties remain in full compliance.
5. You are not required to accept this License, since you have not signed it. However, nothing else
grants you permission to modify or distribute the Program or its derivative works. These actions are
prohibited by law if you do not accept this License. Therefore, by modifying or distributing the Program
(or any work based on the Program), you indicate your acceptance of this License to do so, and all its
terms and conditions for copying, distributing or modifying the Program or works based on it.
6. Each time you redistribute the Program (or any work based on the Program), the recipient
automatically receives a license from the original licensor to copy, distribute or modify the Program
subject to these terms and conditions. You may not impose any further restrictions on the recipients'
exercise of the rights granted herein. You are not responsible for enforcing compliance by third parties to
7. If, as a consequence of a court judgment or allegation of patent infringement or for any other
reason (not limited to patent issues), conditions are imposed on you (whether by court order, agreement
or otherwise) that contradict the conditions of this License, they do not excuse you from the conditions of
this License. If you cannot distribute so as to satisfy simultaneously your obligations under this License
and any other pertinent obligations, then as a consequence you may not distribute the Program at all. For
example, if a patent license would not permit royalty-free redistribution of the Program by all those who


text:
Our Family Genealogy Pages
Discovering our American, Canadian and European Ancestors
Daniel R. Bush
1. Daniel R. Bush was born on 2 Apr 1982 (son of Joe Bush and Kathleen Muckey); died on 30 Jan 2013.
2. Joe Bush
Joe married Kathleen Muckey. [Group Sheet] [Family Chart]
3. Kathleen Muckey
1. Daniel R. Bush was born on 2 Apr 1982; died on 30 Jan 2013.
Amy Bush
Chad Bush
Maryn Bush
6. Robert Clyde Muckey was born on 24 Dec 1933 in New York (son of Joseph Francis Muckey and Erthus Cecelia Dashnau); died on 13 Dec 2002.
Robert married Dora Cotton. Dora (daughter of Thomas Cotton) was born on 14 Jun 1937; died in Jun 1985. [Group Sheet] [Family Chart]
7. Dora Cotton was born on 14 Jun 1937 (daughter of Thomas Cotton); died in Jun 1985.
Donna Muckey
Susan Muckey
Alan Muckey
12. Joseph Francis Muckey was born on 13 Jul 1900 in Constantia, Oswego, New York, United States (son of Frank Muckey and Sarah Suffern Simmons); died on 28 Aug 1985 in Fulton, Oswego, New York, USA; was buried in Fulton, Oswego County, New York, USA.
Joseph married Erthus Cecelia Dashnau on 3 Jul 1922 in Fulton, Oswego, New York, United States. Erthus (daughter of Arthur Napoleon Dashnau and Lucy Mary Talbot) was born on 10 Jul 1902 in Fulton, Oswego Co., NY; died on 12 Jun 1985 in Fulton, Oswego, New York, United States; was buried in Fulton, Oswego County, New York, USA. [Group Sheet] [Family Chart]
13. Erthus Cecelia Dashnau was born on 10 Jul 1902 in Fulton, Oswego Co., NY (daughter of Arthur Napoleon Dashnau and Lucy Mary Talbot); died on 12 Jun 1985 in Fulton, Oswego, New York, United States; was buried in Fulton, Oswego County, New York, USA.
Paul Bernard Muckey was born on 8 Oct 1932 in Crosby Hill, New York; died on 22 Nov 2001 in Tucson, Pima, Arizona, United States; was buried in Hannibal, Oswego County, New York, USA.
June L. Muckey was born on 15 Aug 1928 in Fulton, NY; died on 18 Jun 2009 in Kissimmee, FL.
Ronald L Muckey
6. Robert Clyde Muckey was born on 24 Dec 1933 in New York; died on 13 Dec 2002.
James F Muckey
14. Thomas Cotton
7. Dora Cotton was born on 14 Jun 1937; died in Jun 1985.
Phyllis Cotton
Richard Cotton
Maintained by kevin stewart.


WASHINGTON, D.C. — Today the Consumer Financial Protection Bureau (CFPB) published a bulletin reminding employers that they cannot require their employees to receive wages on a payroll card. The bulletin also explains some of the federal consumer protections that apply to payroll cards, such as fee disclosure, access to account history, limited liability for unauthorized use, and error resolution rights.
The CFPB has heard reports of employers, particularly in the retail and food service industries, distributing wages solely through payroll cards. Federal law, however, prohibits employers from mandating that employees receive wages exclusively on a payroll card. Payroll cards fall under the CFPB's jurisdiction under the Electronic Fund Transfer Act (EFTA) and Regulation E. State law typically governs which alternative payment methods employers must offer.
Disclosure of fees: Payroll card holders are entitled to receive disclosures of any fees that they may incur for electronic transfers of funds to or from the card. These disclosures must be clear, in writing, and in a form that consumers may keep.
Access to account history: The card issuer must either provide periodic statements or generally make card holders' account balances and 60-day account histories available — by phone for the balance, and online, as well as in writing if requested, for the account history. The account history must include information on any fees imposed for fund transfers.
Limited liability for unauthorized use: Payroll card holders' liability for unauthorized use of their cards is limited, provided the unauthorized use is reported within a certain period of time.
Error resolution rights: If a card holder reports a payroll card account error, the financial institution must respond so long as the report is received within a certain period of time.
With some limited exceptions, the CFPB has authority to enforce the EFTA and Regulation E against anyone who violates them, including employers and the financial institutions that issue payroll cards. The Bureau intends to use its enforcement authority to stop violations before they grow into systemic problems, maximize remediation to consumers, and deter future violations. The Bureau also has supervisory authority over larger depository institutions engaged in, among other things, providing payroll cards. The Bureau will be looking to ensure that entities comply with federal consumer financial laws.


Looking for a hotel in Bella Vista? Compare all 4 hotels in Bella Vista (Argentina) and book online.
This is the list of all 4 hotels in Bella Vista.
Featuring free WiFi, Apartamentos Bella Vista is situated in Bella Vista, 28 km from Buenos Aires. Tigre is 17 km away. Free private parking is available on site.
All units include a flat-screen TV. Some units feature a terrace and/or balcony. There is also a kitchen, fitted with an oven, microwave and fridge. A stovetop and kettle are also featured. There is a private bathroom with a bath or shower and bidet in every unit. Towels are offered.
Apartamentos Bella Vista also includes a sun terrace. The property also offers grocery delivery.
Rooms: Apartment, Apartment with Balcony, Duplex Apartment, Standard Apartment.
Rooms at Hotel de La Tour are comfortably furnished and feature carpeted floors and air conditioning. They have a flat-screen TV, a safety deposit box and a minibar. Some rooms also have a hot tub and spa bath.
Other services offered at the hotel include laundry, ironing and room service. The property also has meeting/banquet facilities.
Rooms: Large Double Room, Suite, Superior Double Room.
Hostel Walkiria has a garden and a terrace in Bella Vista. Among the various facilities are a shared lounge and a bar. Free WiFi and a 24-hour front desk are provided.
At the hotel, every room has a desk. Every room is fitted with a private bathroom with a bath or shower and certain rooms here will provide you with a terrace. Guest rooms at Hostel Walkiria include air conditioning and a wardrobe.
Rooms: Bunk Bed in Female Dormitory Room , Bunk Bed in Male Dormitory Room , Bunk Bed in Mixed Dormitory Room, Twin Room.
Bella Vista Bed&Breakfast is located in Bella Vista and features a garden. Boasting a shared kitchen, this property also provides guests with a sun terrace. Free WiFi is included.
All units in the bed and breakfast are fitted with a flat-screen TV. Rooms are complete with a private bathroom, while some rooms at Bella Vista Bed&Breakfast also provide guests with a seating area. The rooms will provide guests with a microwave.
Rooms: Double Room, Studio with Spa Bath.


UK charities are joining a social enterprise that provides them with a new income stream using an innovative take on the £1.7bn greeting card market1.
DontSendMeACard.com provides a comprehensive fundraising toolset for charities to encourage supporters to send digital cards and donate the cost of printed cards to their cause.
Over 100 UK charities have joined the venture including names such as Headway, Sumatran Orangutan Society, the British Deaf Association and the Royal Life Saving Society.
The platform offers charities a high level of customisation including the uploading of custom ecard artwork and the creation of fundraising pages for different occasions.
Individual and corporate supporters can then donate the cost equivalent of cards and stamps, and send ecards via email or share to Facebook.
"The system is built for charities – and with a host of tools and promotional materials at their disposal – they can very easily start fundraising after joining. We've seen generous individuals give as much as £200.00 in lieu of cards and stamps, making it a great source of additional charitable income this Christmas," says Alex Furness, Founder.
- The social enterprise was started in 2013. Founded by Alex Furness of Future Imaging and Craig Lawson of Web Engineer, both based in Exeter.


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Fazerdaze — новозеландський гурт, заснований у Окленд 2014 року. Вокалісткою та фронтвумен гурту є Амелія Мюррей, за якою і закріпилося прізвисько «співачка Fazerdaze». За роки існування співачка разом з сесійними музикантами видали 2 міні-альбоми, а також 1 студійний альбом «Morningside», до якого входить і найвідоміша наразі композиція «Lucky Girl».

Жанр виконання
В основному музика колективу являє собою суміш Lo-Fi та інді-музики. В деяких композиціях помітна схильність до альтернативного року та пост-панку.

Дискографія

EP
 «Fazerdaze» (2015)
 «Little Uneasy» (2015)

Студійні альбоми
 «Morningside» (2017)

Сингли
 «Take it Slow» (2017)
 «Lucky Girl» (2017)

Відеокліпи
 «Little Uneasy» (2016)
 «Take it Slow» (2017)
 «Lucky Girl» (2017)
 «Break!» (2022)
 «Winter» (2022)

Примітки

Посилання
 https://www.groenland.com/artist/fazerdaze/
 https://web.archive.org/web/20170602175606/http://www.theaudience.co.nz/fazerdaze/
 https://soundcloud.com/fazerdaze
 https://www.discogs.com/artist/4442057-Fazerdaze

Новозеландські музичні гурти
Рок-гурти

redpajama_set_name: RedPajamaWikipedia


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4.Install Dominoes Elite for PC.Now you can play Dominoes Elite on PC.Have fun!


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SU, Rockapella set the stage for Family Weekend 2008
Thursday, October 30, 2008, By News Staff
Matthew R. Snyder
As many as 4,000 family members from around the country are getting ready to come to Syracuse University to visit their students during Family Weekend 2008 — and more than a few might be packing Halloween costumes, Rockapella tickets or SU football fan gear as they prepare for the wide range of activities being offered Oct. 31-Nov. 2. With dozens of academic, social, athletic and cultural opportunities on the schedule, Family Weekend 2008 offers unprecedented opportunities for parents, siblings and other family members to engage with their students' SU experience.
Highlights of the weekend will include academic samplers, dean's breakfasts and classroom experiences with some of SU's leading scholars and teachers; "Trick or Treating with the Greeks" and Halloween activities for children on Friday night; the SU football game against Louisville and a variety of student performances on Saturday; and a Pulse performing arts series concert by top-selling a cappella group Rockapella on Sunday afternoon.
"Family Weekend is a tremendous opportunity for SU to celebrate the family members who make it possible for our students to succeed at college," says Colleen O'Connor Bench G'89, director of the Parents Office and founding chair of the national Association of Higher Education Parent/Family Program Professionals. "I am thrilled that so many faculty, staff and especially students are coming together to offer parents and families this special experience."
The Parents Office, a unit of the Division of Student Affairs, hosts Family Weekend in collaboration with offices, departments and recognized student organizations across campus. Most events are free of charge and open to all students and registered family members; some, including the football game and Rockapella concert, require paid tickets. Online registration for Family Weekend has closed, but families can still pay their $40 registration fee on arrival by visiting the Parents Place Hospitality Suite, located in the Panasci Lounge on the third floor of the Hildegarde and J. Myer Schine Student Center. For a complete calendar of events and details about registration, parking, lodging, transportation and tickets, visit http://parents.syr.edu/FW2008.php.
Family Weekend fees support the dozens of no-fee events offered throughout the weekend, as well as the Parents Office's efforts to focus on the evolving needs of SU students and their families. A portion of the ticket proceeds from the Rockapella concert will be used for the Parents Office Special Needs fund, which supports students and families in times of crisis.
For more information about the Parents Office and its services, visit http://parents.syr.edu. To learn about the Pulse performing arts series, visit http://pulse.syr.edu. For more information about Family Weekend, call (315) 443- 1200.
Syracuse Views Fall 2021
We want to know how you experience Syracuse University. Take a photo and share it with us. We select photos from a variety of sources. Submit photos of your University experience using #SyracuseU on social media, fill out a submission…
The United States Need For Better Long-Term Services and Support For the Elderly
Nina Kohn, the David M. Levy Professor of Law and Faculty Director of Online Education in the College of Law, was quoted in the Politico story 'We Don't Fix This Because We Just Don't Care About Old People' Kohn discussed the…
China and the United States Will Work Together To Tackle Climate Change
Dimitar Gueorguiev, assistant professor for political science in the Maxwell School, authored an opinion piece for the Washington Post "The U.S. and China agreed to work together on climate action. What would push this cooperation forward?" and was quoted in…
Astroworld Concert Sparks Online Conspiracies Surrounding the Tragic Event
Jennifer Stromer-Galley, professor in the School of Information Studies and Senior Associate Dean for Academic and Faculty Affairs, was quoted in The Guardian story "Astroworld disaster fuels wave of satanic conspiracy theories on TikTok." Prof. Stromer-Galley was also quoted about…
Is DotDash Acquiring People Magazine A Smart Business Move?
Aileen Gallagher, associate professor of magazine, news and digital journalism in the Newhouse School, was quoted in the New York Times story "People Magazine Heads to New Ownership. Again." With People Magazine recently being bought by the company DotDash, many…


I came across an opinion piece in the Sweetwater Now, written by the owner of the Wyoming Fishing Company in southwest Wyoming. I've not read an opinion piece related to fly fishing so pointed in its criticism of a specific individual. And that's what I think makes me uncomfortable.
The author's comments begin with a pertinent observation about the abuse that results from some brands providing incentives to anglers for use of fishing photos. His concern is that this practice may push some anglers into doing whatever it takes to get a heroic shot – even if there is damage to the environment, such as spawning beds.
He comments that he has seen much of this over the 14 years he's guided, and has, in apparent frustration now called out one abuser.
Citing the cover of the December 2017 issue of American Angler, he goes into specific detail about the incident that caused his reaction. He had very pointed things to say about the Colorado guide involved and his prominent display of brands in the shot, including a Hatch reel and a Thomas and Thomas fly rod. (The author does believe the brands were poorly represented, with which I agree).
The fault it seems to me lies with American Angler magazine that published a photo showing a brown trout with a tail that reflects recent spawning activity. They should have known better.
There is more background on the incident and the author provides additional photos where this same guide has apparently done the same in past years.
I don't know the guide. So it's difficult to assess whether this was an apparently repeated case of ignorance, poor judgment, or casual indifference. I think a guide's job is to educate not only on casting or how to catch fish, but more importantly on the preservation and respect of the fisheries. One would hope he would have been better mentored, if only judged by his behavior in this incident.
I have no quarrel with the concerns the author has expressed. I agree that whether brand ambassadors or everyday fly fishers it can be too easy to make poor choices to get a heroic shot or video of a trophy fish; we should all be abiding by an ethos of take only memories – leave the fish in the water.
But I think the author would have been better served by contacting the brands involved and laying out the points he made in this editorial. Attacking an individual online means both the author and guide will be forever linked, and perhaps tarnished.
In the end, I guess I'm most concerned that this is just another example of the corruption commercial interests can have on everything – including fly fishing.
You can read the editorial here and form your own opinion.


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breadcrumbs Home » Topics A–Z » Key clinical-trial evidence for pembrolizumab
Key clinical-trial evidence for pembrolizumab
Author: Anoma Ranaweera, Medical Writer, Auckland, New Zealand. DermNet NZ Editor in Chief: Adjunct A/Prof Amanda Oakley, Dermatologist, Hamilton, New Zealand. First published December 2014; updated March 2018. Copy edited by Gus Mitchell/Maria McGivern.
This article was updated with financial support from Merck Sharp & Dohme (New Zealand) Limited, distributors of Keytruda® in New Zealand. Sponsorship does not influence content.
Key clinical-trial evidence for pembrolizumab — codes and concepts
Treatment or procedure
Programmed death receptor-1 inhibitor, PD-1 blocker, Metastatic melanoma
SNOMED CT:
716125002, 706031000168100
Pembrolizumab (Keytruda®) is a highly selective humanised monoclonal antibody directed against the programmed cell death 1 (PD-1) receptor on T cells. The drug blocks the PD-1 receptor, thereby preventing the formation of programmed cell death ligand 1 (PD-L1) complexes. This mechanism causes the activation of T-cell mediated immune responses against tumour cells.
On 4 September 2014, the US Food and Drug Administration (FDA) approved pembrolizumab as a breakthrough therapy for the treatment of metastatic melanoma, based on response rates demonstrated in clinical trial data from 173 patients with melanoma in a cohort of the KEYNOTE-001 study.
Since then results from two further clinical trials (KEYNOTE-002 and KEYNOTE-006) have continued to show the benefit of pembrolizumab for the treatment of advanced unresectable or metastatic melanoma.
Pembrolizumab is now registered for the treatment of advanced (metastatic or unresectable) melanoma in many countries worldwide, including Europe, the UK, and New Zealand.
Subcutaneous metastatic melanoma
The KEYNOTE-001 study
The efficacy of pembrolizumab was investigated in a multicentre, open-label, randomised (1:1), dose-comparative Phase 1b study.
The key eligibility criteria were unresectable or metastatic melanoma with progression of disease and refractory to treatment with two or more doses of ipilimumab (3 mg/kg or higher), and, if BRAF V600 mutation-positive, a BRAF or MEK inhibitor, and disease progression within 24 weeks following the last dose of ipilimumab.
Patients were randomised to receive 2 mg/kg n = 89 or 10 mg/kg n = 84 of pembrolizumab every 3 weeks until unacceptable toxicity or disease progression that was symptomatic.
Assessment of tumour status was performed 12 weeks after the first dose of pembrolizumab and every 12 weeks thereafter.
The major efficacy outcome measures were duration of response and confirmed overall response rate (ORR) according to Response Evaluation Criteria in Solid Tumors (RECIST 1.1) as assessed by a blinded independent central review.
The ORR was 24% (95% CI: 15–34) in the 2 mg/kg arm, consisting of one complete response and 20 partial responses.
Among the 21 patients with an objective response, three (14%) had disease progression at 2.8, 2.9, and 8.2 months, respectively, after the initial response.
The duration of response in the remaining 18 patients (86%) varied from 1.4 to 8.5 months and included eight patients with ongoing responses of 6 months or longer.
Similar ORR results were observed in the 10 mg/kg arm.
The response rate did not differ significantly between patients who had received prior ipilimumab treatment and those who had not.
Table 1 presents adverse reactions identified from analyses of the 89 patients with unresectable or metastatic melanoma who received pembrolizumab 2 mg/kg every 3 weeks.
The median duration of exposure to pembrolizumab was 6.2 months (range: 1 day to 15.3 months) with a median of nine doses (range: 1–23).
Pembrolizumab was discontinued in 6% of the 89 patients because of adverse reactions.
Table 1. Drug-related adverse reactions occured in > 10% of patients in KEYNOTE-001
Pembrolizumab 2 mg/kg every 3 weeks (n = 89)
All grades (%)
Grade 3 (%)
General disorders and administration site conditions
Fatigue 47 7
Peripheral oedema 17 1
Chills 14 0
Pyrexia 11 0
Diarrhoea 20 0
Nausea 30 0
Abdominal pain 12 0
Cough 30 1
Dyspnoea 18 2
Rash 29 0
Pruritus 30 0
Vitiligo 11 0
Arthralgia 20 0
Myalgia 14 1
Back pain 12 1
Headache 16 0
Dizziness 11 0
Increased AST 24 2
AST: aspartate transaminase
KEYNOTE-002 was a Phase II study that assessed the efficacy and safety of two pembrolizumab doses compared with investigator-choice chemotherapy in patients with ipilimumab-refractory melanoma.
Patients had histologically or cytologically confirmed unresectable stage III or stage IV melanoma that had progressed within 24 weeks of the last ipilimumab dose (minimum two doses, 3 mg/kg once every 3 weeks) and/or had had previous BRAF or MEK inhibitor therapy, or both (if mutant-positive).
Patients were randomised (1:1:1) to receive intravenous pembrolizumab 2 mg/kg or 10 mg/kg every 3 weeks or investigator-choice chemotherapy (paclitaxel plus carboplatin, paclitaxel, carboplatin, dacarbazine, or oral temozolomide).
Tumour assessments were done before starting study treatment (baseline), at Week 12, every 6 weeks through to Week 48, and then every 12 weeks thereafter.
The primary endpoint was progression-free survival, the time from randomisation to first documented disease progression per RECIST v1.1 by an independent central review, or death from any cause, whichever occurred first.
Results are summarised in Table 2.
Table 2. Summary of efficacy parameters in KEYNOTE-002.
Pembrolizumab 2 mg/kg (n = 180)
Pembrolizumab 10 mg/kg (n = 181)
Chemotherapy control (n = 179)
Progression free survival (% of patients) assessed by RECIST v1.1 by investigator review
Progression free at 6 months 3326 45% (37–52) 15% (10–21)
Progression free at 9 months 32% (25–40) 36% (29–44) 10% (6–15)
Progression free survival (% of patients) assessed by modified RECIST v1.1 by independent central review
Progression free at 6 months 43% (35–50) 48% (40–55) 17% (12–23)
Best overall response (no. of patients) assessed per RECIST v1.1 by independent central review
Complete response 4 (2%) 5 (3%) 0
Partial response 34 (19%) 41 (23%) 8 (4%)
Progressive disease 84 (47%) 86 (48%) 111 (62%)
RECIST, Response Evaluation Criteria in Solid Tumors
The incidence of Grades 3–4 drug-related adverse events in KEYNOTE-002 higher in patients treated with chemotherapy compared to those treated with pembrolizumab.
The most common treatment-related adverse events with chemotherapy were alopecia, anaemia, decreased appetite, fatigue, nausea, and vomiting.
The treatment-related adverse events that were more frequent with pembrolizumab were rash, pruritus, and diarrhoea.
Table 3 is a summary of adverse events in KEYNOTE-002.
Table 3. Summary of adverse events — KEYNOTE-002
Fatigue 38 (21%) 2 (1%) 0 51 (28% 1 (< 1%) 0 54 (32%) 8 (5%) 0
Pruritus 37 (21%) 0 0 42 (23%) 0 0 6 (4%) 0 0
Nausea 8 (4%) 0 0 15 (8%) 1 (< 1%) 0 52 (30%) 3 (2%) 1 (< 1%)
Decreased appetite 8 (4%) 0 0 15 (8%) 2 (1%) 0 26 (15%) 0 0
Anaemia 4 (2%) 1 (< 1%) 0 7 (4%) 0 0 26 (15%) 9 (5%) 0
Rash 21 (12%) 0 0 18 (10%) 0 0 8 (5%) 0 0
Alopecia 5 (3%) 0 0 1 (< 1%) 0 0 24 (20%) 1 (< 1%) 0
Vomiting 1 (< 1%) 1 (< 1%) 0 9 (5%) 1 (< 1%) 0 22 (13%) 3 (2%) 1 (< 1%)
Arthralgia 12 (7%) 1 (< 1%) 0 10 (6%) 1 (< 1%) 0 8 (5%) 1 (< 1%) 0
Myalgia 7 (4%) 2 (1%) 0 7 0 0 9 (5%) 1 (< 1%) 0
Diarrhoea 15 (8%) 0 0 17 (9%) 2 (1%) 0 11 (6%) 3 (2%) 0
Neutropenia 1 (< 1%) 0 0 1 (< 1%) 0 0 8 (5%) 4 (2%) 2 (1%)
Leucopenia 0 0 0 0 0 0 8 (5%) 4 (2%) 2 (1%)
Health-related quality of life
Health-related quality of life (HRQoL) was assessed using the Global Health Status (GHS)/HRQoL scores of the European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30 (EORTC QLQ-C30) at baseline, Weeks 3, 6, 12, 24, and 36, at treatment discontinuation, and during safety follow-up.
HRQoL was maintained to a greater degree with pembrolizumab versus chemotherapy, with fewer patients treated with pembrolizumab experiencing deterioration in GHS at Week 12 (31.8% patients with pembrolizumab 2 mg/kg, 26.6% for 10 mg/kg, and 38.3% for chemotherapy).
In addition to the GHS/HRQoL score, patients in the two pembrolizumab arms had consistently smaller longitudinal score changes from baseline to Week 12 across functional scales, including physical, cognitive, social, and emotional functions, and across symptoms scales including fatigue, nausea/vomiting, pain, dyspnoea, insomnia, appetite loss, constipation, and diarrhoea.
Table 4. Change from baseline to Week 12 in the GHS score of the EORTC QLQ-C30 in KEYNOTE-002
Treatment arm
Change from baseline least squares mean (95% CI)
Mean ± SD
Pembrolizumab 2 mg/kg Q3W
66.2 ± 22.1
−2.6 (−6.2 to 1.0)a
Pembrolizumab 10 mg/kg Q3W
-2.6 (−6.0 to 0.9)a
−9.1 (−12.9 t −5.4)
a P = 0.01 versus chemotherapy.
The Phase III KEYNOTE-006 study showed superior overall and progression-free survival of pembrolizumab versus ipilimumab in patients with advanced melanoma.
834 patients with advanced melanoma were enrolled and randomly assigned to receive intravenous pembrolizumab every 2 weeks (n = 279), intravenous or every 3 weeks (n = 277), or intravenous ipilimumab every 3 weeks (n = 278).
Median follow-up was 22.9 months.
The estimated 6-month progression-free survival rates were 47.3% for patients receiving pembrolizumab every 2 weeks, 46.4% for those receiving pembrolizumab every 3 weeks, and 26.5% for those receiving ipilimumab.
One-year estimates of overall survival were 74.1% for patients receiving pembrolizumab every 2 weeks (hazard ratio for death as compared with the ipilimumab group, 0.63; 95% CI: 0.47–0.83; p < 0.0005), 68.4% for those receiving pembrolizumab every 3 weeks (hazard ratio for death as compared with the ipilimumab group, 0.69; 95% CI: 0.52–0.90; p = 0.0036), and 58.2% for those receiving ipilimumab.
24-month overall survival rate was 55% in the 2-week group, 55% in the 3-week group, and 43% in the ipilimumab group.
The primary patient-related outcome assessment in KEYNOTE-006 was the score change from baseline to Week 12 in EORTC QLQ-C30 GHS/HRQoL score between treatment arms, using a constrained longitudinal data analysis.
From baseline to Week 12, GHS/HRQoL scores were better maintained with pembrolizumab than with ipilimumab (decrease of −1.9 and −2.5 for pembrolizumab vs −10.0 for ipilimumab; p < 0.001 for each pembrolizumab arm vs ipilimumab; see Table 5).
Fewer patients treated with pembrolizumab experienced deterioration in GHS at Week 12 (31% for pembrolizumab every 2 weeks; 29% for pembrolizumab every 3 weeks, and 44% for ipilimumab), with similar trends being observed for individual functioning and symptoms scales.
Table 5. Change from baseline to Week 12 in the GHS score of the EORTC QLQ-C30 — KEYNOTE-006
Change from baseline
Mean (SD)
LS mean (95% CI)
Pembrolizumab 10 mg/kg Q2W 239 71.4 (20.4) 172 71.1(19.3) −1.9 (−4.86 to 1.01)
Pembrolizumab 10 mg/kg Q3W 230 70.5 (21.9) 188 69.5 (22.3) −2.5 (−5.32 to 0.37)
Ipilimumab 213 67.4 (24.0) 149 64.3 (25.8) −10.0 (−13.16 to −6.85)
CI, confidence interval; EORTC QLQ-C30, European Organisation for Research and Treatment of Cancer Quality-of-Life Questionnaire-Core 30; GHS, Global Health Status; LS, least squares; Q2W, every 2 weeks; Q3W, every 3 weeks; SD, standard deviation
In KEYNOTE-006, the most common treatment-related adverse events of any grade occurring in the pembrolizumab groups were fatigue (20.9% in the 2-week group and 19.1% in the 3-week group), diarrhoea (16.9% and 14.4%, respectively), rash (14.7% and 13.4%, respectively), and pruritus (14.4% and 14.1%, respectively).
For ipilimumab, the most frequent adverse events were pruritus (25.4%), diarrhoea (22.7%), fatigue (15.2%), and rash (14.5%).
The findings of the KEYNOTE-001, KEYSTONE-002 and KEYSTONE-006 trials establish pembrolizumab as a new standard of care for melanoma and support the accelerated approval granted by the US FDA for the use of pembrolizumab in patients with unresectable or metastatic melanoma whose disease had progressed after ipilimumab and, if BRAF V600 mutant-positive, a BRAF inhibitor.
HRQoL was better maintained with pembrolizumab than with chemotherapy (KEYNOTE-002) or ipilimumab (KEYNOTE-006), further supporting the use of pembrolizumab in patients with ipilimumab-refractory melanoma.
Overall, the combination of prolonged progression-free survival and overall survival, a decreased incidence of high-grade toxicity, and a better HRQoL provided by pembrolizumab compared with ipilimumab or chemotherapy, supports the use of this drug as a standard of care for patients with advanced melanoma.
The New Zealand approved datasheet is the official source of information for this prescription medicine, including approved uses and risk information. Check the New Zealand datasheet on the Medsafe website.
Robert C, Ribas A, Wolchok JD, et al. Anti-programmed-death-receptor-1 treatment with pembrolizumab in ipilimumab-refractory advanced melanoma: a randomised dose-comparison cohort of a phase 1 trial. Lancet 2014 Sep 20; 384(9948):1109-17. DOI: 10.1016/S0140-6736(14)60958-2. PubMed
Hamid O, Robert C, Daud A, et al. Safety and tumor responses with lambrolizumab (anti-PD-1) in melanoma. N Engl J Med 2013; 369: 134–44. DOI: 10.1056/NEJMoa1305133. PubMed
Poole RM. Pembrolizumab: first global approval. Drugs 2014; 74: 1973–81. DOI: 10.1007/s40265-014-0314-5. PubMed
Hamid O, Puzanov I, Dummer R, et al. Final analysis of a randomised trial comparing pembrolizumab versus investigator-choice chemotherapy for ipilimumab-refractory advanced melanoma. Eur J Cancer 2017; 86: 37–45. DOI: 10.1016/j.ejca.2017.07.022. PubMed
Schadendorf D, Dummer R, Hauschild A, et al. Health-related quality of life in the randomised KEYNOTE-002 study of pembrolizumab versus chemotherapy in patients with ipilimumab-refractory melanoma. Eur J Cancer 2016; 67: 46–54. DOI: 10.1016/j.ejca.2016.07.018. PubMed
Petrella TM, Robert C, Erica Richtig, et al. Patient-reported outcomes in KEYNOTE–006, a randomised study of pembrolizumab versus ipilimumab in patients with advanced melanoma. Eur J Cancer 2017; 86: 115–24. DOI: 10.1016/j.ejca.2017.08.032. PubMed
Robert C, Schachter J, Long GV, et al. Pembrolizumab versus ipilimumab in advanced melanoma. N Engl J Med 2015; 372: 2521–32. PubMed
Schachter J, Ribas A, Long GV, et al. Pembrolizumab versus ipilimumab for advanced melanoma: final overall survival results of a multicentre, randomised, open-label phase 3 study (KEYNOTE-006). Lancet 2017; 390(10105): 1853–62. DOI: 10.1016/S0140-6736(17)31601-X. PubMed
Gangadhar TC, Hwu WJ, Postow MA, et al. Efficacy and safety of pembrolizumab in patients enrolled in KEYNOTE-030 in the United States: an expanded access program. J Immunother 2017; 40: 334–40. DOI: 10.1097/CJI.0000000000000186. PubMed
Dabrafenib
Pembrolizumab
KEYTRUDA® (pembrolizumab) for injection, for intravenous use — US FDA prescribing information, September 2014 (pdf)
Keytruda — Medsafe New Zealand manufacturer datasheet (pdf)
Cancer treatment with Keytruda — Information for patients in New Zealand provided by the manufacturer
Keytruda® (pembrolizumab) Healthcare Professionals Portal — MSD Oncology


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Debut host Wild eager for fittingly frigid Winter Classic
The Minnesota Wild are preparing to play in the NHL's Winter Classic for the first time.
Whitmer kidnapping plot defense seeks to dismiss indictment
Defense attorneys want to dismiss the indictment against five men accused of plotting to kidnap Gov. Gretchen Whitmer because of what they described as "egregious overreaching" by federal agents and informants, according to a court filing. In the 20-page motion, which was filed Saturday night, defense attorneys allege FBI agents and federal prosecutors invented a conspiracy and entrapped people who could face up to life in prison. The request comes after developments and claims about the government's team, including the conviction of Richard Trask, an FBI special agent who was arrested on a domestic violence charge and later fired and convicted of a misdemeanor.
Lawsuit seeks $1M after Michigan teacher cuts girl's hair
The father of a 7-year-old Michigan girl whose hair was cut by a teacher without her parents' permission has filed a $1 million lawsuit against the school district, a librarian and a teacher's assistant.
First sentence to be handed down in kidnap plot of Michigan Governor Gretchen Whitmer
Ty Garbin told prosecutors six men trained at his property, constructing a "shoot house" to resemble Whitmer's vacation home and "assaulting it with firearms."
GM recalls all Chevy Bolts due to fire risk, says owners should park outside and limit charging
The latest recall will cost the company about $1 billion, bringing the total cost of the Bolt battery recalls to $1.8 billion.
Nelly Korda wins in Michigan for 2nd victory of year
Nelly Korda became the first two-time winner on the LPGA Tour this season, closing with a 5-under 67 on Sunday for a two-stroke victory in the Meijer LPGA Classic.
6 men charged with conspiring to kidnap Michigan Gov. Gretchen Whitmer, face maximum penalty of life in prison
It says Fox later met Garbin, a leader of a Michigan group called the "Wolverine Watchmen," at a rally outside of the Michigan Capitol in Lansing. At a meeting in Grand Rapids, the two men and other members of the Watchmen agreed to work together "toward their common goals," the document says.
COVID-19 vaccine shipments begin in historic US effort
Shots are expected to be given to health care workers and nursing home residents beginning Monday. Initial surveys have found that even some health care workers don't want to be first in line. Dr. Graham Snyder, who's led the vaccine task force at Pennsylvania health care giant UPMC, estimates that about half of its employees are willing to get the vaccine as soon as it's offered. But many health officials expect enthusiasm to grow. The Moderna vaccine will be reviewed by an expert panel Thursday and soon afterward could be allowed for public use.
'Shame': Protesters tell Michigan lawmaker to certify vote for Biden as he goes to meet Trump at White House
The Michigan Senate's Republican majority leader and other state lawmakers were greeted Friday by protestors' signs saying "SHAME" and chants of "certify the vote" as he headed to meet with President Donald Trump. Trump is expected to lean on them to overturn President-elect Joe Biden's victory in that state, according to an NBC News report. Majority Leader Mike Shirkey and the others were confronted by about 20 protestors after they arrived at Reagan International Airport, just outside Washington, D.C., before their White House meeting. Romney was the 2012 GOP nominee for president; his late father, George Romney, had been governor of Michigan. That's what they're going to tell the president," the leader said.
Michigan couple with 14 sons welcome their first daughter
This November 2020 photo provided by Jay Schwandt shows Maggie Schwandt. A Michigan couple whose large family attracted attention by growing to include 14 sons welcomed their first daughter nearly three decades after the birth of their first child. Maggie Schwandt was born Thursday, Nov. 5, 2020, at a hospital in Grand Rapids, Mich. (Jay Schwandt via AP)LAKEVIEW, Mich. – A Michigan couple whose large family attracted attention by growing to include 14 sons has welcomed their first daughter nearly three decades after the birth of their first child. Their oldest child, Tyler Schwandt, 28, said his parents thought they would never have a daughter after 14 sons. They wed in 1993, before they attended Ferris State University, and before they graduated the couple had three sons.
The Latest: Trump set to spend election night at White House
President Donald Trump arrives with Vice President Mike Pence for a campaign rally Monday, Nov. 2, 2020, in Grand Rapids, Mich. (AP Photo/Carlos Osorio)If you need help with the Public File, call (713) 778-4745.
China says it's not trying to replace US, won't be bullied
U.S. Attorney General William P. Barr speaks at the Gerald R. Ford Presidential Museum in Grand Rapids, Mich., Thursday, July 16, 2020. The United States has become overly reliant on Chinese goods and services, including face masks, medical gowns and other protective equipment designed to curb the spread of the coronavirus, Attorney General Barr said Thursday. Her comments came in response to a speech Thursday by Attorney General William Barr in which he cautioned American business leaders against promoting policies favorable to Beijing. Hua dismissed Barr's accusations of cybertheft related to vaccine development as absurd." Chinese companies have moved swiftly to develop a coronavirus vaccine, as countries compete for the prestige and profits that would come with being the first to bring such a product to market.
Five surprising new markets enter 2019's top 10 ZIP codes
It takes just 17 days on average for a home in these ZIP codes to sell, 40 days faster than the rest of the nation. Also driving the top 10 markets are relatively affordable home prices, large numbers of high-earning millennials and low unemployment. The average home price in these ZIP codes is $272,000, well below the national price. The median income of residents in these ZIP codes is $64,000, 9% lower than the rest of the top 10. The number of households in these markets is expected to jump 4.3% this year, far higher than the 1.1% national rate.
Stolen "Wizard of Oz" ruby slippers found after 13 years
The slippers were stolen from the Judy Garland Museum in Grand Rapids, Minnesota, the town where the actress was born
Four States brace for snow amid blizzard warning
Four States brace for snow amid blizzard warning New England is not the only place getting blanketed, as snow was falling overnight near Grand Rapids, Michigan. Blizzard warnings are posted for parts of the state. Meteorologist Danielle Niles has the details.


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Beau Baron Takes Win, David Haagsma Clinches Championship
Posted on October 18, 2015 by Podium Promotions	Leave a comment
Primm, NV – Beau Baron's quick thinking pit strategy paid off as he won his second consecutive Rocky Mountain ATV WORCS presented by Maxxis and Dirt Wheels series at Buffalo Bill's. David Haagsma's second-place finish handed him the 2015 WORCS ATV Pro Championship. Mike Sloan made his Pro debut and finished third. Robbie Mitchell and Collins Webster rounded out the top five.
With rain on and off all weekend and temperatures in the mid-70s, the track was fast and fun, and Baron made the most of it. The ATV event was run in conjunction with the Motorcycle class, but the ATV course split for much of the course.
Mitchell took advantage of the fast and tacky condition and nabbed the holeshot at the dead engine start. Haagsma, whose goal was the title, was on a mission and grabbed the lead on the first lap, with Baron just behind. At the midpoint of the race, Baron elected to short pit and only take fuel. That move put him in the lead for good and handed him the victory.
Baron overcame injuries suffered earlier this year to finish strong with two straight wins, but he fell short on regaining the points lead and finished the year in the second spot.
Haagsma was simply out to finish third or better to clinch the title. After losing the lead to Baron, he elected to run a conservative pace to protect his championship. Haagsma is heading to the East Coast next season and plans to run the full ATV Motorcross Nationals season. Winning the WORCS title was an important milestone for Haagsma, but he will be back at the WORCS series for races that don't conflict.
Sloan made his Pro debut after clinching the Pro-Am Championship at the last round. He was pleased with this third-place finish after having to charge from the back of the pack. In the end, cramping legs and a flat tire slowed Sloan's charge to the front.
Mitchell's quad suffered a front wheel bearing failure, which forced him to have an extended pit stop, his team changed the front spindle and bearing and got him back out. He charged back to finish fourth.
David Flores won the Pro Am race, running from the back to the front. After a disappointing start, he picked off positions all race, taking the lead on the final lap and the eventual victory.
Mathew Hancock finished in the second spot followed by Alex Ortiz at the WORCS season finale.
The 2016 WORCS season kicks off on January 15-17th in Taft, California at Honolulu Hills.
tagged with Alex Ortiz, ATV Pro-AM, BEAU BARON, Buffalo Bills Casino, COLLINS WEBSTER, DAVID HAAGSMA, dirt wheels, Mathew Hancock, MAXXIS, Primm NV, PRO ATV, Robbie Mitchell, Rocky Mountain ATV MC


Stacey is in charge of our food shopping and up until very recently, Stacey had always done a "big shop" once a month at the local ASDA store. We'd always order the same bits month after month and have the same meals week after week.
It doesn't help that me and Poppy are very fussy. I'm not very adventurous when it comes to trying new foods and nor is Poppy, our 4 year old girl. I'd imagine Poppy has just picked up on the foods that I eat, maybe heard me say I do not like this or that and decided to come to the same conclusion! Our fussiness results in Stacey, sometimes, having to cook three different meals. No fair really.
Anyway, Stacey decided in an attempt to save some extra money, to do a weekly shop and to plan our meals. By planning we could prepare meals that we all would eat and we'd only need to buy the food we needed for those meals. We took this idea from the BBC's Eat Well for Less TV show and even bought the book. There is around 80 different recipes in this book and I would really recommend it to anyone who has fussy eaters, or anyone looking to save a few pounds.
Without further ado, here's a vlog of our first attempt at cooking one of the recipes. Hope you enjoy and please, let me know if you are in the same situation and what you do to keep the whole family fed and happy!


Investigators from Rock County, Wisconsin, are one step closer to solving the mystery surrounding the death of an unknown teenager thanks to Smithsonian scientists.
Artist's sketch issued by the Rock County Coroner's Office showing what John Clinton Doe may have looked like at age 16.
Christine France, a physical scientist at the Smithsonian's Museum Conservation Institute, was asked to help pinpoint the region where a white male whose skeletal remains were discovered in 1995 on the bank of Turtle Creek near Clinton, Wis., may have grown up. Police estimate John Clinton Doe, so named because he was found near Clinton, was about 18 years old and had been dead for about one year before his remains were discovered by hunters. He was wearing only one Nike Air sneaker and a T-shirt bearing the logo from the English rock band Venom. France was asked by Wisconsin police "to analyze the stable isotope values in the femur bone from the unidentified individual," she says.
Oxygen isotope values embedded in bones can indicate the geographical region where a person lived. Harnessing the power of stable isotope analysis, France was able to help police narrow their search to a teenager who likely once lived in Wisconsin, Michigan or Minnesota. While the cause of his death remains undetermined, investigators believe this new information will greatly assist in identifying the boy and hopefully resolving the case. Police have already assembled a long list of missing persons who have been ruled out as this individual.
Isotopes are variants of a particular chemical element. While all the isotopes of a given element, like oxygen, have the same number of protons in each atom, the number of neutrons differs between them. This changing number of neutrons alters the atom weight of each isotope allowing France to calculate an isotope ratio value based on the combinations of atoms of differing weight. "We created a fine powder from a sample of the individual's femur bone. This allowed us to extract the oxygen isotopes from the bone by separating them into their different weights using our stable isotope mass spectrometer," France said.
Many different combinations of oxygen isotopes exist in our environment and our bodies. These variations found in the bones can help scientists identify a likely geographic location from which the individual came, based on known variations in oxygen isotopes found in drinking water.
Oxygen isotopes are not the only elemental tools in France's scientific toolbox when it comes to discovering the historic background of human remains. Isotopes of carbon and nitrogen also can reveal information about the diet and demographics of an individual. These indicators, however, are not as useful for modern forensic cases.
Although called upon every now and then to help police with modern mysteries, France and her colleagues specialize in developing techniques to assist archeological investigations. In their work to find the best bone isotope indicators for region of origin, racial identity and social class, France and her colleague Douglas Owsley found that these techniques can give us insight into key moments of our history. Owsley is a forensic anthropologist at the Smithsonian's National Museum of Natural History.
While investigators may never be able to put a name to some historic or modern day human remains, scientific techniques like stable isotope analysis now allows them to get a better understanding of a person's background, which could result in a better chance of solving the mystery.


text:
Antonella Bechi Piaggio – moglie di Umberto Agnelli, madre di Giovanni Alberto Agnelli, figlia di Giovanni Alberto Bechi Luserna
 Gino Bechi – baritono italiano
 Giovanni Alberto Bechi Luserna – ufficiale e scrittore italiano, figlio di Giulio Bechi
 Giulio Bechi – scrittore e ufficiale italiano, padre di Giovanni Alberto Bechi Luserna
 Luca Bechi – allenatore di pallacanestro italiano
 Stanislao Bechi – ufficiale, zio di Giulio Bechi


Looking for a daily, visible presence in the market place? High Resolutions can wrap your fleet with partial to full wraps, door magnets or removable decals. Whether you're sitting in traffic or cruising down the freeway, our fleet wraps are a cost effective and powerful way to make a lasting impact on the road.
Impact, visibility, targeting, and longevity, all benefits of giving your company's fleet some compelling advertising. A blank commercial van or truck is a waste of space, but a work vehicle utilizing that empty space is in a league all of its own. Fleet graphics work 24 hours a day and are the perfect way to get non-stop exposure. When comparing the cost to that of expensive, multi-media advertising, fleet graphics are a fraction of the cost. Customized to target your audience and region, we offer a variety of materials including reflective wraps to ensure the most effective short term or long-term advertising alternatives. Our talented creative team can assist in the design and our team of installers can arrange installation locally or nationally for your entire fleet.
We can take your artwork or start from scratch and give your branding a look all its own. Once the artwork is printed, we laminate it to protect against fading and abrasions. Utilizing premium materials with vibrant colors and state-of-the-art technology, we'll cover your entire vehicle if desired.
If you want a partial wrap, our design staff is very skilled at strategically placing graphics that will give your vehicle optimal coverage exposure. Partial wraps are cost-effective and impactful while showcasing your brand to match your vehicle style. Featuring premium vinyl materials and vibrant inks that won't fade or streak, a partial wrap is an excellent solution for just the right exposure.
Looking for a way to display graphics on your windows without blocking the ability to see out? Or perhaps you don't want to cover the entire surface of your vehicle with over-powering graphics? High Resolutions can create state-of-the-art photos, logos, or any marketing graphics with a unique blend of visual interest to provide the perfect view through vinyl treatment. Designed to showcase the vehicle's style and your company's brand, our view through vinyl applications are high impact advertising that gets the job done.
Give your fleet a professional, cohesive look while capitalizing on rolling advertising. Guaranteed to provide your business with a recognized trademark all around town, High Resolutions' van wraps feature cutting-edge creativity with endless commercial appeal. Using premium materials and vibrant, UV resistant inks, we can wrap the entire van, or focus on the windows, backend, sides, or a custom, unique look that suits your brand best.
Do you have a one-of-a-kind design in mind for your truck? We create custom looks that will set your vehicle apart on the highway. Whether you're looking for definitive commercial branding or just some fun graphics that will make you smile, a High Resolutions' truck wrap is sure to exceed your expectations. Featuring top-of-the-line materials and bold, UV resistant inks, our seasoned, graphic designers can create a look that is unforgettable.
Boost your company's business presence around town by featuring your logo on a door magnet. Available in standard and custom sizes and shapes, High Resolutions' door magnets are printed on a vinyl magnetic stock that is all-weather resilient. We use premium UV-resistant inks that maintain a bold presentation. Affordable and practical, our door magnets will market your business with an unlimited visual presence everywhere you go.
Looking for a versatile temporary way to advertise on your vehicle? High Resolutions can provide full-color, removable decals that will give you the option of removing your brand when desired. Designed to peel off easily, our decals are fashioned from premium vinyl materials that are super durable. Printed with UV resistant inks, a High Resolutions' removable decal is the perfect solution to give your vehicle marketing versatility.


Today, one in 6 people lack access to safe, affordable water and the United Nations expects this number to rise. Amid this crisis, some of the world's wealthiest corporations–like Nestlé and Coca-Cola–are making a profit, often at the expense of the poor. Water, like air, is a necessity of human life. It is also, according to Fortune magazine, "One of the world's great business opportunities. It promises to be to the 21st century what oil was to the 20th." A vibrant international movement is challenging the corporate control of this precious resource, and defending water as a public good and an inalienable right.


Successful leaders of today are expected to provide their employees with a sense of meaning in their work as well as provide an engaging workplace. Yet, according to a recent Gallup poll, 70 percent of U.S. employees are "not engaged" at work. How is this possible?
People need to feel their work matters. In order for this message to be communicated with authenticity, the leader must come from a place of emotional resonance. You have to truly believe in your employees and genuinely appreciate the contributions they make every day.
With a mindful attitude and a set of clearly defined principals, you have the power to shape your destiny as a leader at any juncture. Are you the type of leader people want to follow? Do you understand what sets extraordinary leaders apart from all the others? Inspired leadership necessitates casting away personal and psychological barriers and recognizing, cultivating, and maintaining that connection. If you unveil and remove the barriers you have placed over your heart, your paradigm for the way you see, approach and work with others will shift.
We all have unique goals and ideals, and to access them, you need to slow down and take a look within — and listen to your heart. You'll find that by doing so, you become more connected with who you are and with those around you. Put your heart into your interactions with coworkers and employees, rather than looking for outward recognition as a leader. The focus is to serve the people that you are leading, not the other way around. Once you begin to incorporate Heart-Centered leadership practices, the most powerful shifts can occur in your relationships, and business outcomes.
Here are five signs of a heart-centered leader. One who leads by inspiration and encouragement, not by fear and control.
1. You maintain people's self-esteem.
Leadership requires first connecting to, then inspiring, people. When you regularly express gratitude and treat employees with respect — you lead your people by example and set them up for alignment with others. This also engenders trust. The bonds of trust can only be forged when you consistently show your team that they are valued, listened to and involved.
2. You replace blame with responsibility.
3. You don't assume, or judge — you come to understand.
It's amazing what can be accomplished when you have the willingness to assume that people have positive intentions. Strive to be more open-minded. Ask better questions. Being consistent in making every attempt to understand the behavior of your colleagues, customers, friends, and family — rather than automatically assuming you know what happened or what they are thinking — will yield substantial, long-term rewards.
4. You know your impact.
An inspired, heart-centered leader is always cognizant of how words and actions may be interpreted. When you have the integrity and foresight to understand that everything you do and say has an impact — you'll begin to consciously direct your energy and intentions. If you can master this, the perilous outcomes brought about by short-range thinking and impulsiveness comes to a halt.
The biggest challenge you may have as a leader is the pressure to perform at an accelerated pace, and at higher levels, for the business to be profitable. This means experiencing a great deal of stress to achieve goals and objectives. Longer working hours, 24/7 access and fewer resources can create a mountain of pressure and stress — and because the pressure is on you to perform, you may put yourself last. However, remember there is a reason that when flying you are asked to "place your oxygen mask on yourself before helping others." If you are not strong, mentally and physically, then it is unlikely you will be able to take care of your business and your employees. When you are healthy, focused and calm, your positive behavior can't help but enhance employee productivity and engagement.


Just get or renew your commission? Purchase your Official Wyoming Notary Seal Stamp here at Simply Stamps, professional grade tools for your workplace. Be sure your Wyoming Notary Seal Stamp is updated with the latest Notary design! Please provide the name, county and expiration date below.
Wyoming Notary Rectangle Stamp Details This Wyoming Notary Rectangle Stamp features the State Seal of Wyoming, which features a banner saying "Equal Rights". The men on the seal signify the industry of the state. Stamp Size is 2.375" x .75". Don't hesitate and purchase yours here!


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Пя́тая Магистра́льная у́лица — улица, расположенная в Северном административном округе города Москвы на территории Хорошёвского района.

История
Улица получила своё название 6 июля 1957 года как часть системы транспортных магистралей между многочисленными промышленными предприятиями, сосредоточенными на стыке Хорошёвского и Пресненского районов.

Расположение
5-я Магистральная улица, являясь продолжением 2-го Магистрального тупика, проходит от 1-й Магистральной улицы на северо-восток, с запада к ней примыкает Магистральный переулок, далее с востока — 2-й Хорошёвский проезд, 5-я Магистральная улица проходит далее до Хорошёвского шоссе. Сквозной проезд по участку между 2-м Хорошёвским проездом и Хорошёвским шоссе ранее был невозможен из-за пересекавших 5-ю Магистральную улицу подъездных путей (данный факт вошёл в число «дорожных парадоксов» Московского центра борьбы с пробками, с которым заместитель мэра Москвы П. П. Бирюков обещал разобраться до 1 августа 2012 года). По состоянию на январь 2014 года по улице имеется сквозной проезд. На южном участке 5-й Магистральной улицы между 1-й Магистральной улицей и Магистральным переулком расположен действующий железнодорожный переезд (подъездной путь к Московскому мельничному комбинату № 3). Нумерация домов начинается от 1-й Магистральной улицы.

Примечательные здания и сооружения
По нечётной стороне:
 Дом № 5 — федеральное государственное бюджетное образовательное учреждение дополнительного профессионального образования «Академия переподготовки работников искусства, культуры и туризма»
По чётной стороне:

Транспорт

Автобус
 27: от Магистрального переулка до 2-го Хорошёвского проезда и обратно.

Метро
 Станция метро «Беговая» Таганско-Краснопресненской линии — восточнее улицы, в начале Хорошёвского шоссе.
 Станция метро «Полежаевская» Таганско-Краснопресненской линии — северо-западнее улицы, на Хорошёвском шоссе.

См. также
 Первая Магистральная улица (Москва)
 Вторая Магистральная улица (Москва)
 Третья Магистральная улица (Москва)
 Четвёртая Магистральная улица (Москва)
 Магистральный переулок (Москва)
 Первый Магистральный проезд
 Первый Магистральный тупик
 Второй Магистральный тупик

Примечания


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Q: Wordpress: Add extra fields in user profile with respect to user roles I want to add extra fields in user profile with respect to user roles.
Actually I am creating a website on wordpress which requires to type of users Buyers and Sellers. And I have already created two custom roles 'Buyer' and 'Seller'.
Now I need some different fields for user with buyer role and some different fields for user with seller role.

A: Following are the resources that may help you achieving the required functionality
Adding fields when editing - but your custom fields will not come up if you are adding a user(for this its the next link)
https://wordpress.stackexchange.com/questions/23813/adding-fields-to-the-add-new-user-screen-in-the-dashboard
Adding the custom fields when adding the new user from the CMS
http://justintadlock.com/archives/2009/09/10/adding-and-using-custom-user-profile-fields
For showing the different fields based on role
https://wordpress.stackexchange.com/questions/52547/different-fields-in-my-profile-page-depending-on-user-role
I guess the specified code in the above link might not work when you are adding the user from the cms you have to hook some javascript and hide and show your desired fields based on the role - use the following code to achive this.
 function hide_options(){
echo "\n" . '<script type="text/javascript">jQuery(document).ready(function($) {

);

function syncMailingAddress(){

    jQuery("#mailing-address").val(jQuery("#address").val());
    jQuery("#postaladdress").val(jQuery("#address").val());

}
</script>' . "\n";
}
add_action('admin_head','hide_options');

redpajama_set_name: RedPajamaStackExchange


Nokia, the brand which once used to have dominance over whole mobile phones market… is back to the play ground with a new yet powerfull flagship smart phones, The Nokia 8. Launched in August of 2017 this smartphone has already created a splash in the smartphone market. The phone comes with a 5.30-inch touchscreen display with a resolution of 1440 pixels by 2560 pixels at a PPI of 554 pixels per inch.
The Nokia 8 is powered by 1.8GHz octa-core Qualcomm Snapdragon 835 processor. The memory department is handled by 4GB of RAM. The phone comes with 64GB of internal storage that can be expanded up to 256GB via a microSD card. As far as the cameras are concerned, the Nokia 8 packs a 13-megapixel primary camera on the rear and a 13-megapixel front shooter for selfies. For powering the device, Nokia inserted a massive 3900mAh non-removable battery. It measures 151.50 x 73.70 x 7.90 (height x width x thickness) and weigh 160.00 grams.
HMD Global has finally decided to plunge into the dual-rear camera trend. The phone has a vertically stacked set of dual rear cameras (13MP Colour sensor with OIS + 13MP Mono sensor), and there's a front 13MP camera all well. Nokia 8 has PDAF, IR range finder, dual tone flash on the rear camera, and yes there's the Zeiss Optics branding as well that used to be standard on older Nokia phones.
Like most other dual cameras, the Nokia 8 is capable of shooting a bokeh mode, for portrait pictures where the background is blurred.


Click the "i" icon of the card you no longer need.
A window will appear with its description and stats, with buttons below: Sell, Evolution, Fuse.
Click the "Sell" button to get rid of the card and gain some silver.


text:
Q: Question about Conditional Expectation from One Variable I'm having a bit of trouble understanding how to solve this question in my textbook.
It says to allow X to have the following distribution:

Suppose you are then told that $X \geq 2$. Record a prediction of a future value of X
that uses this information.
I know that I need the expectation, but I was struggling a bit to find $\text{E}(X|X \geq 2)$. $$\text{E}(X|X \geq 2) = \sum_x{x\Pr(X=x|X \geq 2)}$$ and $$\Pr(X=x|X \geq 2) = \frac{\Pr(X=x \cap X\geq2)}{\Pr(X \geq 2)} \\ \Pr(X=x \cap X\geq2) = \frac{1}{2} \\ \Pr(X \geq 2) = \frac{1}{2}$$ so $$\text{E}(X|X \geq 2)= 8$$ which doesn't seem right at all.
edit: I'm really not sure how I got 8 lol!

A: The probability that $X=x$ and $X\geq 2$ is not a flat $1/2$.   It depends on what value of $x$ we have.
Clearly $\mathsf P(X=1\cap X\geq 2)=0$ but for all $x\geq 2$ there $\mathsf P(X=x\cap X\geq 2)=\mathsf P(X=x)$
$$\begin{array}{|c|c|}\hline x & 1 & 2 & 3 & 4 \\\hline\mathsf P(X=x\cap X\geq 2) & 0 & 1/4 & 1/8 & 1/8 \\\hline \end{array}$$
$$\mathsf E(X\mid X\geq 2) =\dfrac{2\cdot 1/4+3\cdot 1/8+4\cdot 1/8}{1/2}=\dfrac{11}{4}$$

A: The summation binds $x$ to a (series of) particular value(s).  In your first line that ends with 1/2, you're using the union of all values $\geq 2$, but that's wrong for the probability expression in the sum.  You have to fill in 2, 3, 4 for $x$, one by one for both $x$'s in the sum.
(I'll let you work out the rest.)
[Not sure how you got 8, but it doesn't matter!]


Can you tell us what Lollipop Kids is all about?
This is an idea that was born out of the creative environment of your own family right?
How has the story evolved for the comic page from the bedtime story it started out as?
Aiden – As you've been more involved in creating this story than anything previous, such as co-creating characters with your dad for Suicide Squad or Teen Titans, what has been surprising or challenging about this process?
I love the idea that Nick is part of this bigger world and legacy that he knew nothing about. I think, as kids, we all imagine there is some secret world we belong to that's bigger than ourselves. Is that an idea that will explored in the story, belonging?
What are some of the other themes that will be explored in the story?
How did you bring your artist Diego Yapur onboard?
What has the collaboration been like?
What is it about Diego's style that you feel sutis this story so perfectly?
Aiden – What has the experience been like for you to see these pages of artwork come in and see your ideas so expertly brought to life by Diego?
Anything to else to share with our listeners? Other projects?


text:
Karl Müller (* 16. Juli 1825 in Friedberg (Hessen); † 24. September 1905 in Bonn) war ein deutscher evangelischer Geistlicher und Naturforscher.

Leben
Müller wurde als Sohn des Rektors am Friedberger Schullehrerseminar und Volkslieddichters Peter Müller geboren. Er besuchte die Augustinerschule in Friedberg und ab 1841 das Gymnasium in Darmstadt. Zum Wintersemester 1843/44 immatrikulierte er sich an der Hessischen Ludwigs-Universität. 1844 wurde er im Corps Teutonia Gießen recipiert. Er zeichnete sich als Fuchsmajor und Consenior aus und machte sich einen Namen als herausragender Mensurfechter. Im Wintersemester 1848/49 bestand er das theologische Fakultätsexamen, im November 1851 das Staatsexamen. 1852 wurde Müller die Verwaltung der Mitprediger- und Rektoratsstelle in Alsfeld übertragen. Der Gemeinderat schlug ihn 1862 einstimmig für die vakante Stelle des zweiten Pfarrers von Alsfeld vor, die er nach Bestätigung durch den Landesherren antrat. 1874 wurde er erster Pfarrer, 1875 Mitglied der Landessynode, im selben Jahr Vorsitzender des Stadtschulvorstandes, 1882 Dekan des Dekanats Alsfeld.

Seit den 1860er Jahren veröffentlichte Müller, meist gemeinsam mit seinem Bruder Adolf Müller, der als Oberförster in Gladenbach und Krofdorf tätig war, eine Reihe von populären zoologischen Arbeiten, zunächst als Aufsätze in der Gartenlaube, im Daheim und in Westermanns Monatsheften. 1865 erschien seine erste Buchveröffentlichung "Charakterzeichnungen der vorzüglichsten deutschen Singvögel", der rasch weitere folgten, 1867 ein Jagdalbum in zwei Teilen ("Waidmanns Heil" und "Der Hund und seine Jagd") und 1873 "Die einheimischen Säugetiere und Vögel in ihrem Nutzen und Schaden in der Land- und Forstwirtschaft", das von den Ministerien verschiedener Länder den höheren Lehranstalten zu Lehrzwecken empfohlen wurde. 1883 veröffentlichten die Brüder Müller ihr Hauptwerk "Tiere der Heimat", das 1894 in einer zweiten Auflage herauskam. Auch die anderen Werke erreichten eine weite Verbreitung. Ein enger Austausch bestand mit Alfred Brehm, der wiederholt im Alsfelder Pfarrhaus zu Gast war.

Veröffentlichungen
 Gefangenleben der besten einheimischen Singvögel (1871)
 Unsere nützlichen Säugetiere (1876)

Auszeichnungen
 Ehrenbürger der Stadt Alsfeld (1877)

Literatur
 Academische Monatshefte 22 (1905/06), S. 243f.

Weblinks

Einzelnachweise

Evangelischer Geistlicher (19. Jahrhundert)
Zoologe
Ehrenbürger im Vogelsbergkreis
Corpsstudent (19. Jahrhundert)
Person (Alsfeld)
Geboren 1825
Gestorben 1905
Mann


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