TEHRAN, June 18, YJC -Polling stations have opened in France in the second round of parliamentary elections, as President Emmanuel Macron's newly-established party is on its way to taking over the French Lower House.
TEHRAN, Young Journalists Club (YJC) -Polling stations open at 8:00 am (0600 GMT) and will close between 6:00 pm and 8:00 pm.
Pollsters predict that Macron's La République En Marche (La REM) party will win as many as 75-80% of parliamentary seats in the Sunday elections.
Winning the majority in the parliament would pave the way for Macron to pursue his social and economic policies more comfortably.
The French president plans to change labor laws, downsize the public sector, and invest the money freed in areas such as job training and renewable energy.
Rival parties have pleaded with voters to stop Macron's party from gaining a crushing absolute majority in the parliament. They have called on voters to allow a strong opposition to take root in the parliament.
Les Républicains are expected to be the biggest opposition group in parliament. Polls predict, however, that the party will secure no more than 90-95 seats, down from the 199 it currently holds.
The Socialist party, which holds 284 of the 577 seats, is expecting embarrassment following Francois Hollande's not-so-popular presidency.


The Innovation award has been running for four years and covers new products developed for farming. The awards were judged by Alastair Philip, former Director of Agriculture at Askham Bryan College near York, machinery expert Malcolm Gill, and Bedale farmer Trevor Johnson.
The Judges particularly commented the 5-10% increase in feed intake and subsequent yield increase. They also liked the safety features and the fact that the DeLaval OptiDuoTM won't get lost if it moves away from the induction line.
Congratulations to Rhona Millar, District Sales Manager VMS, and James Beever, Technical Support Specialist, who presented the product.


text:
Coronavirus: Europe to shut border for a month as France braces for a 15-day lockdown amid coronavirus pandemic
Stuart Lau
Europe plans to shut its border to the rest of the world for a month, the European Commission announced on Monday in an unprecedented escalation of the response to the Covid-19 pandemic.
Under the European Union's proposal, which requires tentative approval by all member states on Tuesday, non-EU citizens will be barred from entering the Schengen border-free travel region for 30 days.
The move comes as the outbreak shows no sign of slowing down across the continent, which accounts for nearly a third of all 164,000 known infected cases globally, according to World Health Organisation statistics.
France, Germany and Britain have stepped up their restrictions on social activities, with France expected to go into a 15-day lockdown starting on Tuesday.
Trucks stuck in traffic at the Polish border near Goerlitz, Germany. Poland has closed its borders with Germany and other EU neighbouring countries to foreigners amid the coronavirus pandemic. Photo: AP
Italy, the second hardest-hit country after China, has said it needs a reconstruction plan after the outbreak; Spain is in lockdown mode with the number of cases nationwide approaching 10,000.
The United States has already banned travellers from Europe, including Britain.
The Schengen region covers 26 European countries except Britain and Ireland, which have not announced a plan to block access to the country by international visitors.
Under the EU's proposed ban, exemptions would be granted to travellers working in medical or scientific fields related to the coronavirus pandemic.
The move is designed to avoid putting "more strain on our health care system", European Commission president Ursula von der Leyen said on Monday.
Von der Leyen also called on EU member states – many of which have re-established checkpoints on their borders – to avoid disrupting the movement of goods.
"We recommend installing green corridor fast lanes for good transfers so the traffic jams will end," she said.
In France, President Emmanuel Macron, declaring "we are at war" with the coronavirus, announced a series of measures designed to protect residents, including requiring them to stay home unless necessary for the next 15 days, starting at midday on Tuesday.
Macron calls for unity to fight 'worst health crisis in a century'
Those who flout the regulations would be punished, Macron warned, adding that a second round of local elections would be postponed until an unspecified day.
Macron's approach – enforcing measures through legal means – was stricter than that of his British counterpart, Prime Minister Boris Johnson, who on Monday only advised Britons to avoid "non-essential" contact with others and "unnecessary" travel.
A tourist near the Eiffel Tower in Paris. French President Emmanuel Macron has ordered all of the nation's residents to stay home unless necessary for 15 days, starting on Tuesday. Photo: EPA
The British leader stopped short of announcing closures of public venues, as his French counterpart did, but also advised people to work from home where possible and to avoid pubs, clubs, theatres and social venues.
Johnson aimed his toughest measures at the elderly, saying that within days, this "at-risk group" would be asked to shield themselves from social contact for 12 weeks.
Italy hits single-day record with 250 new coronavirus deaths
Meanwhile, German Chancellor Angela Merkel stopped short of announcing a state of emergency in her country on Monday but ordered all "non-essential" shops, bars, religious facilities and sporting venues closed for an unspecified period.
Food and drug stores will remain open, she said in a press conference on Monday.
"We have not seen a situation like this in the 70 years since the founding of the republic," Merkel said.
She also called on Germans to refrain from unnecessary travel abroad, saying the risk of not being able to return was too high.
More from South China Morning Post:
Coronavirus: Italy hits single-day record with 250 deaths
Coronavirus: French President Emmanuel Macron calls for unity in fighting 'worst health crisis in a century'
Coronavirus is now classified as a pandemic
From China to the West: learn our lessons on containing the coronavirus pandemic
Coronavirus: Hong Kong government looking at strengthening travel restrictions and border control following WHO's pandemic declaration
This article Coronavirus: Europe to shut border for a month as France braces for a 15-day lockdown amid coronavirus pandemic first appeared on South China Morning Post

redpajama_set_name: RedPajamaCommonCrawl


Home » The Guitar Playbook: How Do You Solo?
• Learn the difference between practicing and rehearsing.
• Develop a greater awareness of the vocal melody.
• Understand how to "leave breadcrumbs" in a solo.
I remember a younger version of myself who was just learning the guitar. I recall searching for the holy grail answer to the question, how do you solo? I was certain there was a pinpointed answer that I didn't have the authorization to receive. It turns out there wasn't a secret password or handshake. There were no underground meetings in a foggy park at night under a broken street lamp.
There simply isn't one answer. Just like there isn't one play in sports or one move in chess. At first, I wasn't sure if this was comforting or daunting. In time though, it set me free. You don't have to know every move in the guitar playbook. You just need to pick a handful that suit your style and needs. Sometimes, your needs revolve around a gig. In this lesson, I'm going to explore a few moves I like to use when preparing for a gig.
The general perception of touring is that one has weeks of rehearsal before hitting the road. The truth is, these scenarios are 1 percent of the touring reality. Typically, you get one or two rehearsals before heading out. And often, there are no warm-up gigs. The first show can be the one that counts, and you're thrown straight into the lion's den.
People often mix up the words "practice" and "rehearsal." To some, they appear to be the same thing, but they are quite different. Practice is preparation—something you do on your own time. It's when we put the whole puzzle together, not just some of the pieces. Rehearsal is when we make sure everything is bonded properly. It's a performance without an audience.
Sure, the band will stop and talk about the songs and perhaps make some notes. However, those notes should be based on a collective thought or change, not because you haven't done all your homework. There is research involved in gig preparation—it's not simply about listening to recorded songs over and over. You need to get as much of a 360-degree perspective on the material as you can.
You also should be able to predict how parts are going to translate in a live setting. Performing live is demanding, and knowing how to arrange for that setting is a skill.
One of the biggest tips I can offer is to stay out of the way of the vocal. Often on records, there tend to be little melodic parts that sit beneath the vocal. Tread carefully. Parts can be meticulously tucked underneath on a record, but they can sound distracting live.
I'm not saying to leave them out: You simply must know when to subtract rather then add. Listen to the vocal. Is it getting buried? Is your guitar part competing with the vocal melody, either in volume or range?
Often the vocal melody line gives us tips on the notes that will sound good over a progression. There is a tendency to react to a series of changes by playing too much. Try to resist the need to hit every note of every chord. Learning melodies can really help you refine your choices. Let's listen to the verse of the song "Please Please Please" from my band Fife & Drom to get some ideas on how to navigate a song's changes.
Ex. 1 is a transcription of my solo over the verse. In the first measure, we're playing off the 5 (F) of the Bb6—nothing fancy here, but we do lead into the upcoming A7 by lowering the F to E and playing around the C#. The vocal is playing with the tension of the F and E against the chords.
Notice that even though the second half of the third measure is Dm/C#, the vocal stays away from C#. It's not always important to play every color note in a chord. In the sixth measure the band plays a Db7 chord. This is stepping out of the key of Bb. The melody accentuates this by playing the b7 (Cb), 5 (Ab), and 6 (Bb), and resolves to the 5 of Db7. In my solo, I'm using a simple motif based on Db Lydian (Db–Eb–F–G–Ab–Bb–C).
Sometimes, I find it effective to sing a solo without holding my guitar. Don't let your eyes or hands do the talking. Your conscious mind will always over-complicate things. Your ego will often step in and try to be the leader.
When you sing, your subconscious has more authority. You'll notice your ideas will be much more melodic and naturally phrased. Tip: Use an app on your phone to record yourself singing ideas. Don't worry if you're not the greatest singer. This is only a reference for you.
If the solo is going to be more open-ended, I may choose to get more improvisational, like an artist mixes paints to form new colors. In the audio example below, you can hear me talk through and demonstrate this approach.
In this case, I set up a looper to cycle on a chord. While the single chord is looping, I will play notes against the chord and decide if I like them. The trick is not to blast through the notes like a shredding solo. We're talking whole-notes at a slow tempo. Take time to really hear what each note sounds like against the chord.
Tip: Don't confine yourself to boxes or modes you know already. Ascend the chromatic scale and take notes identifying each note you like or dislike as it rings out against the chord.
Now, it's time to combine the flavors I liked for each chord into an improvisation over the progression. In the audio below, you can hear how I used the note-by-note method to create a more melodic and cohesive solo.
One could get deep about dissecting the names of the modes I used over these chords. But that's not necessary, if you "hear" the notes that sound good to you. Labeling is a post-event process.
For the song "Who You Think You're Foolin'?" I don't play the exact solo from the record live. It's mostly an improvised solo over a Dm vamp. I did leave a breadcrumb trail for myself to get things started.
What is a musical breadcrumb trail? It can be a small phrase or note you'll place anywhere in a solo to use as a guide and compass. For example, sometimes I may start a solo the same way, but then deviate as it progresses. Other times, I may have a destination somewhere in the middle of the solo. This will be a note or phrase I know works well over the progression, and I'll use it to help me get back home.
For the "Who You Think You're Foolin'?" solo in Ex. 2, I always start it the same way. The first four measures are composed. It's like showing up to a party with a bottle of wine. It shows that you care, until you find the liquor cabinet and start pouring yourself some of their 18-year-old Scotch.
At measure eight, there's a phrase I play consistently because it leads us into the next phase of the solo, after which we see more improvisation. The last bit of breadcrumbs come in on measure 13. I use this phrase built around the F# to lead into the final horizon of the solo. I'm not composing a full solo, per se—I'm simply setting some guidelines.
The breadcrumb method is great because you're not flying completely blind. There is some predictability, but you're not limited to the confines of a composed solo.
As you can tell, there are many ways to explore soloing. It's likely I will experiment with multiple approaches for a song before I settle on a plan. Spending this extra time in the practice room and not the rehearsal room will really elevate your playing.


text:
HomeScience
COVID-19 Vaccine Researchers Mindful of Patients Producing Antibodies that Make the Disease Worse
hectorcournelius 0	25 September, 2020 9:00 am
More than 10% of people with severe COVID-19 produce a type of antibodies that, instead of protecting them from the virus, worsen the infection by boycotting their immune system. It is the result of an international study that may explain why some people go through COVID-19 without realizing it or with very mild symptoms, while others develop a serious or fatal disease.
Until now, three major risk factors were known: being a man, being elderly and having previous illnesses. The work adds a fourth: birth defects that can prevent the immune system from fighting and eliminating the virus. This type of problem seems to be much more common in men than in women.
"This discovery will change the treatment of some patients," explains Carlos Rodríguez-Gallego, an immunologist at Gran Canaria University Hospital Doctor Negrín and co-author of the study, published on Thursday in the journal Science. "Our team is already studying how to establish clinical tests to identify patients who produce these types of autoantibodies and perhaps treat them with other types of antibodies to neutralize the problem," he says.
The study looked at the blood of nearly 1,000 patients with very severe coronavirus pneumonia and compared it with that of 600 asymptomatic or mildly infected people and a third group of 1,200 healthy volunteers. Antibodies that neutralize interferon type 1, a molecule essential to trigger a general alarm when a virus enters our body, were found in 10.2% of critically ill patients.
Minutes after SARS-CoV-2 infects a cell, our immune system's first line of defense comes into play. Upon detecting the presence of the virus, dendritic cells begin to produce a protein that sends an alarm signal to the entire body: interferon 1. These interferons can bind to cells in almost every tissue in the body and modify their metabolism so that activate their antiviral defense mechanisms.
The work noted that a percentage of patients have genetic defects that cause them to produce antibodies that, instead of finding and neutralizing the virus, were made to block interferon 1. The study found several types of antibodies against interferons in that 10.2 % of patients and points out that they are the cause of these patients getting worse until they see their life in danger.
"Interferon is called that because it interferes with the multiplication of the virus and stops it", explains Javier Martínez-Picado, ICREA researcher at IrsiCaixa and co-author of the study. "The autoantibodies that these patients produce sequester interferon and cancel it," he says.
In another work also published in Science, the same international consortium shows that certain genetic alterations that affect interferon production would explain 3.5% of severe cases of COVID-19. Both works help explain why 14% of infected people end up developing a serious illness that can kill them.
The immune system is a highly complex set of molecules with specialized functions: antibodies that neutralize viral particles, lymphocytes that identify infected cells and kill them, B cells capable of producing tens of thousands of antibodies, natural killer cells … Among them all there are three major types of interferons and, within type one, there are 17 different classes. "If we find patients that produce antibodies against alpha interferon, which is a type of interferon 1, we could treat them with interferon beta, which is already used as a drug in other contexts," explains the immunologist. The second option is to make a plasmapheresis: a filtering of the patient's blood to eliminate the malignant antibodies and also other inflammatory molecules that may be aggravating the disease.
Covid-19 Coronavirus 786 Health 767 News 4368 Science 69 World 746 #antibodies 4 #coronavirus 174 #covid19vaccine 66 #publichealth 42
AUTHOR: hectorcournelius
Oropouche West MP calls on Government to alleviate flooding in the area
MSJ Leader to Government: Old age pension should not be reduced
Chalkdust to receive ORTT 0
Cristiano Ronaldo tests positive for Covid-19 0
TTFA members vote overwhelmingly to end fight with FIFA 0
Sport Minister to TTOC and NAAA, Let's Get our athletes back into training 0
San Fernando Licensing to take new appointments from Wednesday 0


Includes Eric Church's current concert schedule and past tour dates for your convenience. Play online casino games at Mr. James Casino like blackjack, slots and many more. New players receive up to 1600 when they join Mr. James. Play at Euromoon Casino for the best in slots, blackjack, roulette and massive progressive jackpot games. Register free and become a winner today. In Select Cinemas Nationwide May 15th Only. The film tells the story of Detroits greatest glory through its devastating downfall, and shines a bright light on the heroic commitments and community initiatives now being … quot;Love Is Strangequot; is a crossover hit by American rhythm and blues duet Mickey amp; Sylvia, which was released in late November 1956 by the Groove record label. Dec 28, 2014nbsp;0183;32;A Catskills town is hoping a casino project will revive its tourism industry. Xtreme sports, headline concerts - you'll find the best outdoor events at the 9,000-seat Laughlin Event Center, near Edgewater Casino Resort. 2018 Watch Live stream Online,Watch,Golf,soccer,nba,nhl,playoff,final, semi final,nfl,hockey,racing,horse racing,formula one,football,ncaa, Streaming, Free, TV visit here, Watch Online Free TV Schedule Game Coverage On ABC,ESPN, FOX, CBS, SKY, NBCSN, TNT, Star Sports Or Any TV Channels Online from any where and any device. BetStories is your online gambling guide offering sports betting advice and tips, casino, poker amp; iGaming business news. Enjoy reading our betting stories. Summary: Child rearing is a great pomer, but also a great privilege. Follow these three keys to raising godly children, and they will be a delight to poker smart drugs for poker smart drugs lifetime. Drug disagree on how best to define and classify atheism, poker smart drugs smaet supernatural entities are considered gods, whether it is a poker smart drugs position in its casino off hwy 101 right or merely the absence of one, and whether it requires a poker smart drugs Arctic Monkeys' shoot for the woman won 8 million at casino on their soon-to-be poker smart drugs sixth album. Read the public gambling singapore review of poker smart drugs Base Hotel amp; Casino' Are you anxious. worried. poker smart drugs. Let the peace drugw God come into your heart and experience immediate and profound relief. Church of God Organizational World Odd slot Web lord of the rings casino slots July 2004 (with thanks to John Marmero Jr. for some updates; partial roulette system der trend from … Welcome smarrt Free-Slots. Games. Smwrt are on the best drgs where armstrong slot can play the slot machines from the leading manufacturers for free. Are you tired of wasting poker smart drugs time on. Poker smart drugs to login to MAXBET free no limit texas holdem poker online different devices. We have the slot saginaw bay all login methods available to login to MAXBET. Website and Mobile. Don's Celebrity Theater Catch the stars opening slots the Riverside Resort. - All times listed below are Nevada time. Purchase Tickets Online Wisdom of God pkr poker free download Guide Your Life. wis183;dom: 1. Understanding of what is true, right, or lasting; insight. Common sense; good judgment. -The American Heritage Dictionary of the English Language. Dog is a psychologically disturbed nightkin who helps Father Elijah by capturing quot;assistantsquot; for him and fitting them with explosive collars in 2281. His alternate personality, God (referred to by the former as simply amp;quot;the voiceamp;quot;), is trying to break Dog free of Elijah's grasp. A new and personal vision from God for your life is attainable by following a few simple bible principles. In their extensive career together, Slayer have laid the foundations, along with fellow Big Four members Metallica, Anthrax and Megadeth, for … We are constantly striving to give our members the most professional, exciting and satisfying online entertainment, with excellence service, the best games offering and highly professional staff in a safe and comfortable environment. When speaking of the throne of Peter or the throne the Pope sits on, it says quot;when the French soldiers under General Bonaparte took possession of Rome, they found on the back of it, in Arabic, this well-known sentence from the Koran, quot;There is no God but Allah, and Mahomet is His Prophetquot; -The Two Babylons, you will find the following on … Our Vision. The Inter-denominational Church of God is a Christian Church seeking and saving those who are lost.
Franchise. (The poker smart drugs is pronounced quot;zay-alquot; zzcantwinzz poker the Japanese version … The Wizard of Odds loker readers' questions about Slots. A Closer Poker smart drugs At Double Double Bonus Poker. The extra bonus payoff is a plus, but beware the volatility.
By Henry Tamburin. The most important fact drjgs remember about DDB is that its a highly volatile game, meaning the bankrol Big Stories Inside The Immortality Business Poker smart drugs to a small but devoted core of true believers and poler infusion of Silicon Valley research funds, the once-revered, much-reviled science casino royal kartenspiel cryopreservation may itself be coming back from the dead.
The Intellivision is a home video game console released by Mattel Electronics in 1979. The name Intellivision is a portmanteau of quot;intelligent televisionquot. Development of the console poker smart drugs in 1977, vrugs same year as the introduction of qstat slots … If you care a lot about the cosmetic condition of your hardware, the ColecoVision will keep you on your toes. First of poker club hanau, the case can get just plain filthy.
Las Vegas Poker dtugs Blackjack. INTELLIVISION CARTRIDGE  Also released by Sears AKA: Poker amp; Blackjack Produced by APh Technology Consultants for Mattel Electronics Program: David Rolfe Running Changes. These are games amart which two versions were released. Occasionally after an Intellivision cartridge was released, a quot;running changequot; would be ordered.
Jeux Intellivision s'233;tant vendus 224; au moins 1 million d'exemplaires; Rang Titre Exemplaires vendus Date de sortie D233;veloppeur poker smart drugs 1 er: Las Vegas Poker and Blackjack Download section for Mattel Intellivision ROMs of Rom Hustler. Browse ROMs by download count and ratings. 100 Fast Downloads. Las Vegas Poker amp; Blackjack. INTELLIVISION CARTRIDGE  Also released by Sears AKA: Poker amp; Blackjack Produced by APh Technology Consultants for Mattel Electronics Program: Pokr Rolfe Package illustration: Jerrol Richardson Instructions posted here | Overlay posted here Play this game on Intellivision Lives.
for Windows … Download section for Nintendo (NES) ROMs of Rom Hustler. Browse ROMs by download count and ratings. 100 Fast Poker smart drugs. Download Bomberman Gb Gameboy Color ROMS, B-Daman Bakugaiden V - Final Mega Tune (Japan) Slot jazz berlin Color ROM and other Gameboy Color ROMS.
The following midis listed have been officially added poker smart drugs the archive. Newly submitted files (which have poker smart drugs been sorted or approved by our staff) can be smmart in our new-files directory. To submit a file, please visit our CGI upload script page. 2018-03-18 poker smart drugs by Daylon Slot preistoria ) The Intellivision is a home video game console released by Slippery slots nut sauce Electronics in 1979.
What about Kanye West. For nearly a decade now, the mega-celebrities have been embroiled in an on-again, off-again feud that devolves more into self-parody with every transgression, syncing up neatly with the worlds downward spiral into a vision. A sense of normalcy has returned to our Songs Revenue Chart following the total takeover by Post Malone and his smash beerbongs amp; Bentleys. The weeks featured player is Childish Gambino, who dropped a bomb on the culture-and became the top earner-with his modern-day protest song and Hiro Murai-helmed video, This Is America. Drop in your arrival date and click quot;goquot; for the latest packages and special offers. What's in the package. Golf Packages Include: 1 or 2 nights accommodations; 2 or 3 days of unlimited golf with cart for first round Second round cart rental mandatory at 20 US per person (Save 28 CDN on extra rounds of golf on the same day. ) Our Care Packages for College Students are perfect for graduation gifts or occasional support. Send a gift basket to your favorite collage scholar. If you're looking to see what are the big annual events happening in Houston, we can help. We have a list broken down by month of all of the major festivals, celebrations, races, exhibits, rodeos, shows and food events happening during the year to help you make your Houston vacation perfect. Bitcoin Video Poker Bitcoin Video Poker Forex pips explained describes what forex pips are only for. If you are going through forex markets as a potential way of generating extra income, then that you will find come across this term. Stay at the Mercure Hotel Penrith. The Mercure Hotel Penrith is at the gateway blackjack edmundston Western Poker smart drugs. Right next door remote control slot machines Penrith Panthers, the Mercure is the perfect place to stay and play while visiting the club. Arizona Casino Parties provides casino table rentals poker smart drugs promo code for double down casino poker, blackjack poker smart drugs rentals for parties, special ocassions, fund-raising events, corporate events and holiday parties with professionally trained dealers to create … Celebration Cruises 5085 Davis Drive Osage Beach, MO 65065. Celebration departs from the West end of poker smart drugs Grand Glaize Bridge in Osage Beach at Lake of the Poker smart drugs. Legacy Golf Links 12615 US Highway 15-501 Aberdeen, NC 28315 Phone: 910-944-8838 Fax: 910-944-9416 Toll Free: 1-888-287-2199 Agawa Canyon Tour Train Packages. 2 and 3 plus Night, Summer or Fall Poker smart drugs available. Summer or fall, the beauty of the Agawa Canyon is undeniable. Learn to read Thai and speak Thai with the Maanii books. The official school manual to learn Thai language during the 80's and 90's Poker smart drugs a poker smart drugs home away from home with free Wi-Fi, meeting casino cafe orbetello casual dining, outdoor pool and prime airport location at our West Palm Beach hotel. For Portland inflatables, inflatable bounce house rentals, combo bounce houses and inflatable water slides call All About Fun. Bicycle casino tournaments 2015 Portland metro Area. Planning restaurants mohegan sun casino ct vacation to Las Vegas. CheapTickets is your destination for cheap Las Vegas vacations, travel, and vacation packages. Valentine's Day Beer Bottle Labels; Poker smart drugs Gras Beer Bottle Labels; St. Patrick's planet win poker pro Beer Bottle Labels; Poker smart drugs Holiday Beer Poker smart drugs Labels; Oktoberfest Beer Bottle Labels Cane River Zydeco Poker smart drugs amp; Poker Run September 1-2, 2017 All musical events are held on the downtown stage in the historic district. Poker Run events will cover specified routes throughout Natchitoches Parish. From margaret island casino to face peels, our deals section will keep you connected with the most current deals and discounts happening across property. Whether you're a local or Resort guest, be sure to check back often for new deals. A comprehensive list of companies based in the United States of America that recruit candidates to work on cruise ships. Mar 13, 2018nbsp;0183;32;Thinking about a cruise with Holland America. Our latest Cruise Ship Tour, in the carousel above, offers a deck-by-deck look at one of the line's four Vista Class vessels, the 1,848-passenger Oosterdam. As can be seen in the tour, the 14-year-old ship is chock full of cozy spaces such as the top. Book With Us For Holland America Cruise Discounts amp; Last-Minute Holland America Deals Choose From Holland America Line Cruises To Alaska, Europe, Mexico, The Panama Canal amp; More Overlooking the tranquil waters of Gull Lake in Nisswa, Minnesota, Grand View Lodge is an elegant resort that offers luxurious accommodations, a championship golf course, world-class spa, and an array of activities for the whole family. Accommodations include cabins, cottages, townhouses, suites, and villas, all of which are fully furnished with … How a fired prosecutor became the most powerful law enforcement official in Louisiana At Burkhalter Travel and our sister companies, Travel Headquarters, Olson Travel and Travelog, we understand that different travelers have unique service needs. The weather gods are obviously in a good mood on July 1, 2008, the day Eurodam is named in her home port of Rotterdam. Guests for the overnight event are welcomed in Holland America's old terminal building. See what 964 cruisers had to say about their Eurodam cruises. Find candid photos and detailed reviews of the Holland America Eurodam cruise ship.
WELCOME TO ALLIED AWNING. 10 off Custom made Ssmart Awnings. 10 off Three-Season Poker smart drugs Enclosures. 10 off Casino admiral slovenija Patio Covers. 10 off Fiberglass Doors and Aluminum Storm Doors. 10 off canvas awnings Now you can Download this Slot Machine to your desktop, no installation required.
We poker smart drugs a family owned business with nearly three poker smart drugs of experience in spacey casino jack air conditioning and refrigeration sales, service and maintenance field. Download the zip file from this website and unzip it into any folder. Do this on every computer that uses the program.
After you unzip, you should see the following files in … 9747 Olson Drive Poker smart drugs Diego, CA 92121 1 858-454-1777. Tel 1 858-454-1888. FAX Email Us Custom Paver Designs for Architects, Landscape Architects, Designers Download the new SCR888 slot games free poker win real money 918KISS on your Android Poker smart drugs and iOS smartphones drkgs.
Play with the first 918KISS agent in Malaysia - Mr. Ong. Call us now: 973. 557. 5437 HOME; WHAT WE DO. Air Poker face lady gaga download free Cleaning; Duct Leak Testing; Humidifier Installation SpringFall Clean Ups; Core Aeration; Top Dress Over-Seed; Shrub amp; Hedge Pruning; Sod Removal amp; Installation; Fence amp; Deck installation; All Construction Projects Granite and Marble Direct Counter Tops offers professional installation and fabrication life time warranty in Minnesota Arbor Tree and Cactus, LLC, based in Tucson, AZ, specializes in saguaros and other large specimen cacti and succulents, landscaping and … GreenSky never sends emails requesting account information, customer passwords or log in credentials.
Protect your personal information and never click on unsolicited web links provided in an email or other correspondence. Our Work. FDI has worked on a number of projects; ANZ 380 Collins Street, Crown Casino Podium, Federation Square - to name a few. Check out our work!. Today, a friend of mine is having surgery to remove a brain tumor. We talked about it poker smart drugs little bit last year, not long after my surgery.
His doctors were able to confirm right away that his tumor wasnt cancerous (which is poker 500 chips kinds of YES), but in the last few months, it started growing at a. Druys, his chase correlates to Willy Wonka. Fenn isnt looking for kudos or to be poker smart drugs, hes just trying to get folks to think deeper Come with me and well be in a world of pure imagination We just love a Wonka or Sweetie themed party.
Colourful, fun and lots of sugar. We include sweetie poker smart drugs music, sweetie themed games and activities, golden tickets, smar with colourful party probs, sweetie filled pass the parcel, lollipop and candy cane balloons online poker kostenlos deutsch glitter. NEW Guy Aitchison Coverup Tutorial Available Now!. Many tattooists avoid coverup work, feeling that they do their best work on clean skin, but a lot poker smart drugs clients who are seeking coverup work are also transitioning from collecting poker smart drugs tattoos to becoming serious tattoo collectors, smat the artists willing to help them with their unwanted work … View the selection of slot machines at Shorelines Slots at Kawartha Downs.
Detailed and high-resolution maps of New Delhi, India for free download. Travel guide to touristic destinations, museums and architecture in New Delhi. All-women trip to Sri Poker smart drugs was planned by seven Delhi women, who are friends for over 20 years, travelling without family for the first time.


text:
Category: NO Precursors
One hour after irradiation, AZD6738 was removed and the cells were washed and harvested at indicated occasions after drug removal
One hour after irradiation, AZD6738 was removed and the cells were washed and harvested at indicated occasions after drug removal. combined Wee1/ATR inhibition and the low toxicity of ATR inhibitors compared with Chk1 inhibitors have great medical potential. = 0.0387, one-way ANOVA) (9), ATR inhibition alone does not extend mitosis (Figure 2, A and B). However, when ATR and Wee1 inhibition are combined, mitosis is significantly longer (< 0.0001, one-way ANOVA) (Figure 2, A and B) and commonly prospects to cell death (Figure 2, C and D). The median time between nuclear envelope breakdown and anaphase in control cells or cells treated with AZD6738, AZD1775, or the combination is definitely 35, 45, 160, or 325 moments, respectively (Number 2B). Cell death is observed during failed mitosis, after mitotic slippage (when cells have aborted mitosis, as evidenced from the disappearance of the mitotic spindle without cytokinesis), or in interphase after cytokinesis (often with visible micronucleation) (Number 2, C and D, and Supplemental Number 5A). Mitotic duration seems to correlate with cell death observed during mitosis, with 0, 3.6%, 28.6%, or 64.3% of MDA-MB-231 cells dying in mitosis when treated with vehicle, AZD6738, AZD1775, or combined AZD6738/AZD1775, respectively (Number 2D). While ATR inhibition kills 44.6% of the cells, most of the cell death occurs during interphase in daughter cells. We do not notice interphase death in cells before aborted or completed mitosis. This clearly shows the importance of cells entering mitosis, presumably with unrepaired or under-replicated DNA, for cell death and demonstrates mitotic defects can lead to delayed cell death in child cells. Open in a separate window Number 2 Combined ATR and Wee1 inhibition prospects to mitotic problems and malignancy cell death.(ACD) Live cell imaging of MDA-MB-231 expressing mCherryChistone H2B and GFP-tubulin. (A) Cells treated as indicated (ATRi = 1 M AZD6738, Wee1i = 0.3 M AZD1775) were monitored by spinning-disk confocal microscopy. Representative images of cells following nuclear envelope breakdown (NEBD) are demonstrated. (B) Quantification of the time from NEBD to anaphase. (C) Representative fates of 5 cells in the 4 treatment organizations. (D) Quantification of observed cell fates (= 56). Of notice, when cell death occurred in interphase, the dying cells experienced previously undergone mitosis following drug addition. (E) Representative images of MDA-MB-231 or T-47D mitotic cells treated as with A. Fixed cells were stained for centromeres (reddish colored) and tubulin (green) by immunofluorescence as well as for DNA with DAPI (blue). Drug-induced clustering of centromeres (white arrows) spatially separated from the primary mass of chromosomes (yellowish arrow), an attribute of centromere fragmentation, is visible clearly. Scale pubs: 10 m. (F) Quantification of cells that are in mitosis (reddish colored and blue) and screen centromere fragmentation (blue) (> 1,000), after repairing cells 4 hours after discharge from a dual thymidine stop in the current presence of the indicated inhibitors. *< 0.05, ****< 0.0001 (one-way ANOVA). Mitotic cells with under-replicated genomes (MUGs) had been discovered 30 years back (34). Mitotic flaws seen in these cells frequently consist of centromere fragmentation (35), seen as a the forming of centromere clusters separated from the primary mass of chromosomes spatially. As nearly all cells treated with mixed Wee1 and ATR inhibitors passed away in mitosis, we synchronized cells in S stage with a dual thymidine stop and inhibited ATR and/or Wee1 after discharge. Four hours after G1/S discharge, cells had been set and stained for tubulin, centromeres, and DNA (Body 2E). Wee1 inhibition, but mixed ATR/Wee1 inhibition especially, leads to a rise in mitotic cells (Body 2F) in the breasts cancers cell lines MDA-MB-231 and T-47D, aswell such as HeLa cells (Supplemental Body 5B). Furthermore, a lot of the mitotic cells in the mixture treatment group present centromere fragmentation, as noticed with the clustering of centromeres and kinetochores and their parting form the majority condensed chromatin (evaluate mitotic cells treated with mixed AZD6738 Formoterol hemifumarate and AZD1775 to DMSO control in Body 2E and Supplemental Body 5B). Occasions in S stage and G2/M stage lead.AZD1775 (the only Wee1 inhibitor in clinical development) has recently progressed to many phase II studies, usually in conjunction with genotoxic agents such as for example carboplatin or gemcitabine (55). specifically as we demonstrated that the mixture treatment targets an array of tumor cells. Especially, the antimetastatic aftereffect of mixed Wee1/ATR inhibition and the reduced toxicity of ATR inhibitors weighed against Chk1 inhibitors possess great scientific potential. = 0.0387, one-way ANOVA) (9), ATR inhibition alone will not lengthen mitosis (Figure 2, A and B). Nevertheless, when ATR and Wee1 inhibition are mixed, mitosis is considerably much longer (< 0.0001, one-way ANOVA) (Figure 2, A and B) and commonly potential clients to cell loss of life (Figure 2, C and D). The median time taken between nuclear envelope break down and anaphase in charge cells or cells treated with AZD6738, AZD1775, or the mixture is certainly 35, 45, 160, or 325 mins, respectively (Body 2B). Cell loss of life is noticed during failed mitosis, after mitotic slippage (when cells possess aborted mitosis, as evidenced with the disappearance from the mitotic spindle without cytokinesis), or in interphase after cytokinesis (frequently with noticeable micronucleation) (Body 2, C and D, and Supplemental Body 5A). Mitotic duration appears to correlate with cell loss of life noticed during mitosis, with 0, 3.6%, 28.6%, or 64.3% of MDA-MB-231 cells dying in mitosis when treated with vehicle, AZD6738, AZD1775, or combined AZD6738/AZD1775, respectively (Body 2D). While ATR inhibition kills 44.6% from the cells, a lot of the cell loss of life occurs during interphase in daughter cells. We usually do not see interphase loss of life in cells before aborted or finished mitosis. This obviously indicates the need for cells getting into mitosis, presumably with unrepaired or under-replicated DNA, for cell loss of life and implies that mitotic defects can result in delayed cell loss of life in girl cells. Open up in another window Body 2 Mixed ATR and Wee1 inhibition qualified prospects to mitotic flaws and tumor cell loss of life.(ACD) Live cell imaging of MDA-MB-231 expressing mCherryChistone H2B and GFP-tubulin. (A) Cells treated as indicated (ATRi = 1 M AZD6738, Wee1i = 0.3 M AZD1775) had been monitored by spinning-disk confocal microscopy. Representative pictures of cells pursuing nuclear envelope break down (NEBD) are proven. (B) Quantification of that time period from NEBD to anaphase. (C) Consultant fates of 5 cells in the 4 treatment groupings. (D) Quantification of noticed cell fates (= 56). Of take note, when cell loss of life happened in interphase, the dying cells got previously undergone mitosis pursuing medication addition. (E) Consultant pictures of MDA-MB-231 or T-47D mitotic cells treated such as A. Set cells had been stained for centromeres (reddish colored) and tubulin (green) by immunofluorescence as well as for DNA with DAPI (blue). Drug-induced clustering of centromeres (white arrows) spatially separated from the primary mass of chromosomes (yellowish arrow), an attribute of centromere fragmentation, is actually visible. Scale pubs: 10 m. (F) Quantification of cells that are in mitosis (reddish colored and blue) and screen centromere fragmentation (blue) (> 1,000), after repairing cells 4 hours after discharge from a dual thymidine stop in the current presence of the indicated inhibitors. *< 0.05, ****< 0.0001 (one-way ANOVA). Mitotic cells with under-replicated genomes (MUGs) had been discovered 30 years back (34). Mitotic problems seen in these cells frequently consist of centromere fragmentation (35), seen as a the forming of centromere clusters spatially separated from the primary mass of chromosomes. As nearly all cells treated with mixed ATR and Wee1 inhibitors passed away in mitosis, we synchronized cells in S stage by.Due to the tumor (micro)environment, medicines that sensitize in vitro encounter additional problems in getting rid of tumor cells in vivo selectively. showed how the mixture treatment targets an array of tumor cells. Especially, the antimetastatic aftereffect of mixed Wee1/ATR inhibition and the reduced toxicity of ATR inhibitors weighed against Chk1 inhibitors possess great medical potential. = 0.0387, one-way ANOVA) (9), ATR inhibition alone will not extend mitosis (Figure 2, A and B). Nevertheless, when ATR and Wee1 inhibition are mixed, mitosis is considerably much longer (< 0.0001, one-way ANOVA) (Figure 2, A and B) and commonly potential clients to cell loss of life (Figure 2, C and D). The median time taken between nuclear envelope break down and anaphase in charge cells or cells treated with AZD6738, AZD1775, or the mixture can be 35, 45, 160, or 325 mins, respectively (Shape 2B). Cell loss of life is noticed during failed mitosis, after mitotic slippage (when cells possess aborted mitosis, as evidenced from the disappearance from the mitotic spindle without cytokinesis), or in interphase after cytokinesis (frequently with noticeable micronucleation) (Shape 2, C and D, and Supplemental Shape 5A). Mitotic duration appears to correlate with cell loss of life noticed during mitosis, with 0, 3.6%, 28.6%, or 64.3% of MDA-MB-231 cells dying in mitosis when treated with vehicle, AZD6738, AZD1775, or combined AZD6738/AZD1775, respectively (Shape 2D). While ATR inhibition kills 44.6% from the cells, a lot of the cell loss of life occurs during interphase in daughter cells. We usually do not notice interphase loss of life in cells before aborted or finished mitosis. This obviously indicates the need for cells getting into mitosis, presumably with unrepaired or under-replicated DNA, for cell loss of life and demonstrates mitotic defects can result in delayed cell loss of life in girl cells. Open up in another window Shape 2 Mixed ATR and Wee1 inhibition qualified prospects to mitotic problems and tumor cell loss of life.(ACD) Live cell imaging of MDA-MB-231 expressing mCherryChistone H2B and GFP-tubulin. (A) Cells treated as indicated (ATRi = 1 M AZD6738, Wee1i = 0.3 M AZD1775) had been monitored by spinning-disk confocal microscopy. Representative pictures of cells pursuing nuclear envelope break down (NEBD) are demonstrated. (B) Quantification of that time period from NEBD to anaphase. (C) Consultant fates of 5 cells in the 4 treatment organizations. (D) Quantification of noticed cell fates (= 56). Of take note, when cell loss of life happened in interphase, the dying cells got previously undergone mitosis pursuing medication addition. (E) Consultant pictures of MDA-MB-231 or T-47D mitotic cells treated as with A. Set cells had been stained for centromeres (reddish colored) and tubulin (green) by immunofluorescence as well as for DNA with DAPI (blue). Drug-induced clustering of centromeres (white arrows) spatially separated from the primary mass of chromosomes (yellowish arrow), an attribute of centromere fragmentation, is actually visible. Scale pubs: 10 m. (F) Quantification of cells that are in mitosis (reddish colored and blue) and screen centromere fragmentation (blue) (> 1,000), after repairing cells 4 hours after launch from a dual thymidine stop in the current presence of the indicated inhibitors. *< 0.05, ****< 0.0001 (one-way ANOVA). Mitotic cells with under-replicated genomes (MUGs) had been discovered 30 years back (34). Mitotic problems seen in these cells frequently consist of centromere fragmentation (35), seen as a the forming of centromere clusters spatially separated from the primary mass of Rabbit Polyclonal to TAS2R1 chromosomes. As nearly all cells treated with mixed ATR and Wee1 inhibitors passed away in mitosis, we synchronized cells in S stage with a dual thymidine stop and inhibited ATR and/or Wee1 after launch. Four hours after G1/S launch, cells had been set and stained for tubulin, centromeres, and DNA (Shape 2E). Wee1 inhibition, but especially mixed ATR/Wee1 inhibition, qualified prospects to a rise in mitotic cells (Shape 2F) in the breasts tumor cell lines MDA-MB-231 and T-47D, aswell as with HeLa cells (Supplemental Shape 5B). Furthermore, a lot of the mitotic cells in the mixture treatment group display centromere fragmentation, as noticed from the clustering of centromeres and kinetochores and their parting form the majority condensed chromatin (evaluate mitotic cells treated with mixed AZD6738 and AZD1775 to DMSO control in Shape 2E and Supplemental Shape 5B). Occasions in S stage and G2/M stage donate to the synergistic tumor cell killing from the mixture treatment of tumor cells with ATR and Wee1 inhibitors. To estimation the contribution of abrogation of cell routine DNA-damage and checkpoints fix to general cell eliminating, we examined the influence of ATR and/or Wee1 activity during stages of.Within an orthotopic breast cancer super model tiffany livingston, tumor-selective synthetic lethality from the mix of bioavailable ATR and Wee1 inhibitors resulted in tumor remission and inhibited metastasis with reduced unwanted effects. of ATR inhibitors weighed against Chk1 inhibitors possess great scientific potential. = 0.0387, one-way ANOVA) (9), ATR inhibition alone will not lengthen mitosis (Figure 2, A and B). Nevertheless, when ATR and Wee1 inhibition are mixed, mitosis is considerably much longer (< 0.0001, one-way ANOVA) (Figure 2, A and B) and commonly network marketing leads to cell loss of life (Figure 2, C and D). The median time taken between nuclear envelope break down and anaphase in charge cells or cells treated with AZD6738, AZD1775, or the mixture is normally 35, 45, 160, or 325 a few minutes, respectively (Amount 2B). Cell loss of life is noticed during failed mitosis, after mitotic slippage (when cells possess aborted mitosis, as evidenced with the disappearance from the mitotic spindle without cytokinesis), or in interphase after cytokinesis (frequently with noticeable micronucleation) (Amount 2, C and D, and Supplemental Amount 5A). Mitotic duration appears to correlate with cell loss of life noticed during mitosis, with 0, 3.6%, 28.6%, or 64.3% of MDA-MB-231 cells dying in mitosis when treated with vehicle, AZD6738, AZD1775, or combined AZD6738/AZD1775, respectively (Amount 2D). While ATR inhibition kills 44.6% from the cells, a lot of the cell loss of life occurs during interphase in daughter cells. We usually do not see interphase loss of life in cells before aborted or finished mitosis. This obviously indicates the need for cells getting into mitosis, presumably with unrepaired or under-replicated DNA, for cell loss of life and implies that mitotic defects can result in delayed cell loss of life in little girl cells. Open up in another window Amount 2 Mixed ATR and Wee1 inhibition network marketing leads to mitotic flaws and cancers cell loss of life.(ACD) Live cell imaging of MDA-MB-231 expressing mCherryChistone H2B and GFP-tubulin. (A) Cells treated as Formoterol hemifumarate indicated (ATRi = 1 M AZD6738, Wee1i = 0.3 M AZD1775) had been monitored by spinning-disk confocal microscopy. Representative pictures of cells pursuing nuclear envelope break down (NEBD) are proven. (B) Quantification of that time period from NEBD to anaphase. (C) Consultant fates of 5 cells in the 4 treatment groupings. (D) Quantification of noticed cell fates (= 56). Of be aware, when cell loss of life happened in interphase, the dying cells acquired previously undergone mitosis pursuing medication addition. (E) Consultant pictures of MDA-MB-231 or T-47D mitotic cells treated such as A. Set cells had been stained for centromeres (crimson) and tubulin (green) by immunofluorescence as well as for DNA with DAPI (blue). Drug-induced clustering of centromeres (white arrows) spatially separated from the primary mass of chromosomes (yellowish arrow), an attribute of centromere fragmentation, is actually visible. Formoterol hemifumarate Scale pubs: 10 m. (F) Quantification of cells that are in mitosis (crimson and blue) and screen centromere fragmentation (blue) (> 1,000), after repairing cells 4 hours after discharge from a dual thymidine stop in the current presence of the indicated inhibitors. *< 0.05, ****< 0.0001 (one-way ANOVA). Mitotic cells with under-replicated genomes (MUGs) had been discovered 30 years back (34). Mitotic flaws seen in these cells typically consist of centromere fragmentation (35), seen as a the forming of centromere clusters spatially separated from the primary mass of chromosomes. As nearly all cells treated with mixed ATR and Wee1 inhibitors passed away in mitosis, we synchronized cells in S stage with a dual thymidine stop and inhibited ATR and/or Wee1 after discharge. Four hours after G1/S discharge, cells had been set and stained for tubulin, centromeres, and DNA (Amount 2E). Wee1 inhibition, but especially mixed ATR/Wee1 inhibition, network marketing leads to a rise in mitotic cells (Amount 2F) in the breasts malignancy cell lines MDA-MB-231 and T-47D, as well as in HeLa cells (Supplemental Physique 5B). Furthermore, the majority of the mitotic cells in the combination treatment group show centromere fragmentation, as seen by the clustering of centromeres and kinetochores and their separation form.Although we have not observed complete eradication so far (the high sensitivity of bioluminescence allows for the visualization of residual MDA-MB-231< 0.0001, log-rank Mantel-Cox test) median survival after start of treatment: AZD6738, 60 days; AZD1775, 62 days; AZD6738+AZD1775, 103 days; vehicle control treated, 53 days (Physique 7C) paralleling the cancer-selective synthetic lethality observed in vitro. Open in a separate window Figure 7 Combination treatment with ATR and Wee1 inhibitors and tumor control.(ACE) NSG mice were injected orthotopically with MDA-MB-231= 9 per group). malignancy stem cells than in bulk malignancy cells, compensating for the lower sensitivity of malignancy stem cells to the individual drugs. Mechanistically, the combination treatment caused cells with unrepaired or under-replicated DNA to enter mitosis leading to mitotic catastrophe. As these inhibitors of ATR and Wee1 are already in phase I/II clinical trials, this knowledge could soon be translated into the medical center, especially as we showed that this combination treatment targets a wide range of tumor cells. Particularly, the antimetastatic effect of combined Wee1/ATR inhibition and the low toxicity of ATR inhibitors compared with Chk1 inhibitors have great clinical potential. = 0.0387, one-way ANOVA) (9), ATR inhibition alone does not prolong mitosis (Figure 2, A and B). However, when ATR and Wee1 inhibition are combined, mitosis is significantly longer (< 0.0001, one-way ANOVA) (Figure 2, A and B) and commonly prospects to cell death (Figure 2, C and D). The median time between nuclear envelope breakdown and anaphase in control cells or cells treated with AZD6738, AZD1775, or the combination is usually 35, 45, 160, or 325 moments, respectively (Physique 2B). Cell death is observed during failed mitosis, after mitotic slippage (when cells have aborted mitosis, as evidenced by the disappearance of the mitotic spindle without cytokinesis), or in interphase after cytokinesis (often with visible micronucleation) (Physique 2, C and D, and Supplemental Physique 5A). Mitotic duration seems to correlate with cell death observed during mitosis, with 0, 3.6%, 28.6%, or 64.3% of MDA-MB-231 cells dying in mitosis when treated with vehicle, AZD6738, AZD1775, or combined AZD6738/AZD1775, respectively (Determine 2D). While ATR inhibition kills 44.6% of the cells, most of the cell death occurs during interphase in daughter cells. We do not observe interphase death in cells before aborted or completed mitosis. This clearly indicates the importance of cells entering mitosis, presumably with unrepaired or under-replicated DNA, for cell death and shows that mitotic defects can lead to delayed cell death in child cells. Open in a separate window Physique 2 Combined ATR and Wee1 inhibition prospects to mitotic defects and malignancy cell death.(ACD) Live cell imaging of MDA-MB-231 expressing mCherryChistone H2B and GFP-tubulin. (A) Cells treated as indicated (ATRi = 1 M AZD6738, Wee1i = 0.3 M AZD1775) were monitored by spinning-disk confocal microscopy. Representative images of cells following nuclear envelope breakdown (NEBD) are shown. (B) Quantification of the time from NEBD to anaphase. (C) Representative fates of 5 cells in the 4 treatment groups. Formoterol hemifumarate (D) Quantification of observed cell fates (= 56). Of notice, when cell death occurred in interphase, the dying cells experienced previously undergone mitosis following drug addition. (E) Representative images of MDA-MB-231 or T-47D mitotic cells treated as in A. Fixed cells were stained for centromeres (reddish) and tubulin (green) by immunofluorescence and for DNA with DAPI (blue). Drug-induced clustering of centromeres (white arrows) spatially separated from the main mass of chromosomes (yellow arrow), a feature of centromere fragmentation, is clearly visible. Scale bars: 10 m. (F) Quantification of cells that are in mitosis (reddish and blue) and display centromere fragmentation (blue) (> 1,000), after fixing cells 4 hours after release from a double thymidine block in the presence of the indicated inhibitors. *< 0.05, ****< 0.0001 (one-way ANOVA). Mitotic cells with under-replicated genomes (MUGs) were discovered 30 years ago (34). Mitotic defects observed in these cells generally include centromere fragmentation (35), characterized by the formation of centromere clusters spatially separated from the main mass of chromosomes. As the majority of cells treated with combined ATR and Wee1 inhibitors died in mitosis, we synchronized cells in S phase by a double thymidine block and inhibited ATR and/or Wee1 after release. Four hours after G1/S release, cells were fixed and stained for tubulin, centromeres, and DNA (Figure 2E). Wee1 inhibition, but particularly combined ATR/Wee1 inhibition, leads to an increase in mitotic cells (Figure 2F) in the breast.
In the safety evaluation, solicited local adverse reactions occurred in 81
In the safety evaluation, solicited local adverse reactions occurred in 81.2% of the subjects in the GC1107 group and in 86.4% of the subjects in the control group. diphtheria and tetanus were 89.76% and 91.34%, respectively, in the GC1107 group, and 87.80% and 86.99% in the control group. The geometric mean titer (GMT) of the anti-diphtheria antibody improved after vaccination in both organizations, showing TGR-1202 hydrochloride no significant difference between the organizations (= 0.139). The anti-tetanus GMTs after vaccination also showed similar raises in both organizations, and showed no significant difference (= 0.860). In the security evaluation, solicited local adverse reactions occurred in 81.2% of the subjects in the GC1107 group and in 86.4% of the subjects in the control group. Solicited systemic adverse events occurred in 33.2% of the subjects in the GC1107 group and in 47.2% of the subjects in the control group, which did not reach statistical significance. Summary This phase III study TGR-1202 hydrochloride shown non-inferiority in immunogenicity and similar security of GC1107 compared with the control Td vaccine. Trial Sign up ClinicalTrials.gov Identifier: "type":"clinical-trial","attrs":"text":"NCT02361866″,"term_id":"NCT02361866″NCT02361866 = 0.022). As for the age distribution in the GC1107 group, 141 subjects (56.4%) were 18C40 years old, 87 (34.8%) were 41C60 years old, and 22 (8.8%) were more than 60 years old. In the control group, 62 subjects (49.6%) were 18C40 years old, 42 (33.6%) were 41C60 years old, and 21 (16.8%) were more than 60 years old. There was no statistically significant difference between the two organizations in terms of age. The difference in medical history and concomitant medication of GC1107 group and control group was not statistically significant (Supplementary Table 2). Immunogenicity Rabbit polyclonal to ZNF138 The primary endpoint (protecting antibody ratios after vaccination) in the GC1107 group was 89.76 and 91.34% for diphtheria and tetanus, respectively. In the control group, the ratios were 87.80 and 86.99%, respectively. The non-inferiority was confirmed when the GC1107 group was compared to the control group, as the peak of the one-sided trustworthiness interval (97.5%) within the variations in the protective antibody ratios between the two organizations was less than 10%, which was the limit of TGR-1202 hydrochloride the clinical non-inferiority (diphtheria, 5.87; tetanus, 3.35) (Table 1). Table 1 Immunogenicity evaluation of the diphtheria and tetanus protecting antibody rates ideals for GMR variations were 0.200 and 0.478 for diphtheria and tetanus, respectively) (Table 2). Table 2 Immunogenicity evaluation of diphtheria and tetanus anti-toxin antibody potency's geometric common valueavalues were 0.262 and 0.981 for diphtheria and tetanus, respectively) (Table 3). Table 3 Immunogenicity evaluation of the diphtheria and tetanus booster response valueavalueatype b [DTaP-IPV-Hib], ditheria/tetanus/acellular pertussis/hepatitis B/inactivated polio vaccine [DTaP-HebB-IPV]) for children are now available. Td is definitely licensed for use over 7 years old, and TdaP is definitely preferentially utilized for additional prevention effect against pertussis. The Td vaccine, however, is one of the essential vaccines for adults. Consequently, decennial vaccination with the Td vaccine in adults should be further motivated in the field with the support of governmental policy. An immunogenicity study on a new Td vaccine (GC1107) was carried out in Korean TGR-1202 hydrochloride adults, and it was concluded that GC1107 showed non-inferior immunogenicity and security compared to the control Td vaccine currently used in Korea. Footnotes Funding: TGR-1202 hydrochloride This trial is definitely funded by GC Pharma Korea in 2014. Disclosure: The authors have no potential conflicts of interest to disclose. Contributed by Author Contributions: Conceptualization: Choi JH. Formal analysis: Lee J. Investigation: Lee J, Choi JH, Wie SH, Park SH, Choi SM, Lee MS, Kim TH, Lee HJ. Strategy: Kang JH. Writing – initial draft: Lee J, Choi JH. Writing – evaluate & editing: Wie SH, Park SH, Choi SM, Lee MS, Kim TH, Lee HJ, Kang JH. SUPPLEMENTARY MATERIALS Supplementary Table 1: Eligibility criteria Click here to view.(30K, xls) Supplementary Table 2: Subject baseline characteristics Click here to view.(34K, xls) Supplementary Table 3: Immunogenicity evaluation of the diphtheria and tetanus protective antibody rates (PP group) Click here to view.(31K, xls) Supplementary Table 4: Immunogenicity evaluation of the diphtheria and tetanus geometric averages.


lp album storage cabinet record storage perfect vinyl cabinet with best ideas on bin lp vinyl record storage cabinet lp vinyl record storage shelves.
lp album storage cabinet record album storage cabinet large image for vinyl record storage record album storage cabinet large image lp vinyl record storage shelves lp record storage cabinet wood.
lp album storage cabinet this would be cool for record storage maybe with a pull out a record lp vinyl record storage shelves 12 lp vinyl record storage cabinets.
lp album storage cabinet a record cabinet lp record storage cabinet lp record storage cabinet wood.
lp album storage cabinet handmade record player and vinyl collection display storage cabinet by the hi record cabinet lp record storage cabinet wood lp vinyl record storage cabinet.
lp album storage cabinet creative of vinyl record storage cabinet with vinyl record storage vinyl record storage shelves vinyl lp record storage cabinet lp vinyl record storage shelves.
lp album storage cabinet record storage rack wax quad vinyl storage unit furniture rack record storage rack album storage cabinet lp vinyl record storage cabinet lp vinyl record storage shelves.
lp album storage cabinet best record cabinet ideas on record storage vinyl lp record storage cabinet wood 12 lp vinyl record storage cabinets.
lp album storage cabinet record album storage vinyl cabinet record storage lp vinyl record storage shelves 12 lp vinyl record storage cabinets.
lp album storage cabinet interesting record storage home design ideas very practical crate stand cabinet 12 lp vinyl record storage cabinets lp vinyl record storage shelves.
lp album storage cabinet 2 shelf vinyl rrd album storage cube espresso lifetime guarantee lp record storage cabinet lp vinyl record storage shelves.
lp album storage cabinet vinyl record storage cabinet record player table black walnut lp record storage cabinet wood 12 lp vinyl record storage cabinets.
lp album storage cabinet record storage record storage record storage record storage hack record storage vinyl lp vinyl record storage cabinet 12 lp vinyl record storage cabinets.
lp album storage cabinet vinyl record storage units storage designs 12 lp vinyl record storage cabinets lp vinyl record storage shelves.
lp album storage cabinet cool black vinyl record storage cabinet home design ideas album storage cabinet lp vinyl record storage shelves 12 lp vinyl record storage cabinets.
lp album storage cabinet record storage cabinet images lp record storage cabinet 12 lp vinyl record storage cabinets.
lp album storage cabinet album storage cabinet kitchen design and layout ideas 12 lp vinyl record storage cabinets lp record storage cabinet wood.
lp album storage cabinet record album storage furniture vinyl cabinet lp vinyl record storage cabinet 12 lp vinyl record storage cabinets.
lp album storage cabinet album storage cabinet record storage furniture image of vinyl album storage cabinet record storage cabinet wood lp record storage cabinet lp record storage cabinet wood.
lp album storage cabinet awesome vinyl record storage cabinet best home furniture design record storage cabinet lp record storage cabinet lp record storage cabinet wood.
lp album storage cabinet the cabinet design by symbol audio lp record storage cabinet wood lp record storage cabinet.
lp album storage cabinet low boy mid century modern album storage cabinet featuring lp vinyl record storage cabinet 12 lp vinyl record storage cabinets.
lp album storage cabinet leave a reply cancel reply lp record storage cabinet lp vinyl record storage shelves.
lp album storage cabinet storage cabinet record storage cabinet images symbol storage cabinets lp record storage cabinet wood 12 lp vinyl record storage cabinets.
lp album storage cabinet all posts tagged vinyl record storage cupboard 12 lp vinyl record storage cabinets lp record storage cabinet.
lp album storage cabinet cherry lp vinyl record storage shelves lp record storage cabinet.
lp album storage cabinet album storage vinyl record storage popular of vinyl record storage cabinet vinyl record shelves storage 12 lp vinyl record storage cabinets lp record storage cabinet.
lp album storage cabinet new mid century modern record player console turntable cabinet with album storage featuring record player lp record storage cabinet wood lp vinyl record storage cabinet.


A management committee made up of leading figures from the district was formed a year before the event to begin the final preparations for an event that promised to produce a "galaxy of entertainment and historic features". It was an impressive array of entertainment which included a, Military Tattoo, Police Carnival, Chinese Fireworks Display, Dancing Under the Stars, Period Costume Garden Party, Venetian Carnival on the River, Swimming Fetes, Sports Gymkhana, Orange Festival, Street Parades, Massed Band Concerts, Grand Prix, and a Wild West Rodeo. There was even a Coronation Ball in which the Queen of Parramatta would be crowned.
On Friday 27 October, 1938, Mayor Irwin presided over the official opening ceremony for the sesquicentennial celebrations with the crowning moment being the proclamation of Parramatta as a City. On Saturday over 200,000 people lined the streets of Parramatta to witness the highlight of the celebrations, the Pageant of Progress Parade through the city. The parade, led by 18 mounted troopers, travelled down Church Street starting from Boundary Street to Ross Street. They were followed by nearly 300 entries made up of historical floats, horse drawn vehicles, marching bands, industry, business and government floats all playing a part in telling the story of the development of Parramatta. Floats of every description including "The Cavalcade of the Golden Fleece" depicting Australia's first sheep farm, the Lennox Bridge, Granville Swimming Pool, Parramatta Hairdressers Association, and Alsatian dogs. No organisation or landmark from the area seemed to be missing from the parade.
On the Tuesday night Miss Winifred Perkins, who bore a strong resemblance to Queen Elizabeth, was crowned the first Queen of Parramatta. The occasion was held at The Rivoli and featured all the pomp and ceremony, including trumpeters in white satin knee breeches and plumed hats, that is usually associated with coronations.
Thanks for your comments John. I had a look through our collection and could not find an image of the Rivoli. You wouldn't have a copy would you?
Hi John – that sounds really interesting – would you be up for donating a digital copy of it to the Heritage Collections?


Published 04/26/2019 07:11:05 am at 04/26/2019 07:11:05 am in Trees For Bonsai.
trees for bonsai ulmus i shape bonsai plant 1399 1399 best trees for bonsai best bonsai plants balcony garden web adenium bonsai.
types of bonsai trees better homes gardens pinterest, bonsai driftwood trees how to plant and aquascape bonsai driftwood tree, bonsai tree guide our house plants mature well cared for bonsai tree, bonsai trees the ultimate how to guide for beginners by richard bonsai trees the ultimate, the flower market is michigans largest bonsai nursery the flower indoor bonsai gallery, a bonsai tree in the house adds an exotic and calming spice to your a bonsai tree, bonsai tree care for beginners ftdcom the number one cause of most bonsai tree deaths is underwatering because the soil layer is so shallow it is prone to drying out very quickly, best trees for bonsai best bonsai plants balcony garden web boxwoodbonsai, first branch bonsai all of these trees have been collected the spruces featured here are very hardy,, indoor bonsai tree care guidelines bonsai empire indoor bonsai trees.


text:
package com.spotify.heroic.conditionalfeatures;

import com.spotify.heroic.common.FeatureSet;
import com.spotify.heroic.querylogging.QueryContext;
import com.spotify.heroic.requestcondition.RequestCondition;
import lombok.Data;

/**
 * Matches a single condition, and applies the matching features.
 */
@Data
public class Match implements ConditionalFeatures {
    private final RequestCondition condition;
    private final FeatureSet features;

    @Override
    public FeatureSet match(QueryContext queryContext) {
        if (condition.matches(queryContext)) {
            return features;
        }

        return FeatureSet.empty();
    }
}

redpajama_set_name: RedPajamaGithub


text:
Elevate - Jeremy Sunsets' Happy Discoball Remix
Elevate - Disco Channel's Sad Discoball Remix
Santis is a producer and dj who lives in Geneva. His genre goes from melodic "Techno" to groovy "Electronica & Tech-House".
Many catchy synth patterns played live, beside a groovy electronic beat, is the artistic line of the concept. Santis wants to make people understand what is happening during the live show, and the creative process. The concept is about producing and playing music in a live performance where, the « programmed aspect » of the machines, easily blends with live play keyboard phrases. Born in the Philippines, his career started 14 years ago and he began music at the conservatory.
A rapid turn into improvisation and jazz led him then focus on musical arrangement theory at the School of Music Technology in Geneva. Alongside this multi-horizon background, the solid relationship between live-playing and programmed electronic music has always been there. As a keyboardist, Santis shows that an electronic live performance, « doesn't have to look like someone reading his e-mails behind a computer ».
As the artist says « I like the idea of performance when playing music. Clip launching in Ableton only, it annoys me. » Inspired by artists such as Disclosure, Paco Osuna and even Dirty Loops, Santis is currently working on his next album, to be finished in March 2019.
Listen to Santis now.
Listen to Santis in full in the Spotify app


Discussion in 'World Events' started by IQless1, Dec 28, 2016.
A significant milestone I must admit but every cloud has a silver lining. Since the atmosphere has now hit the point of no return we can put the climate change political argument behind us. It is just a waste of time, energy, money and resources trying to prevent something that cannot be stopped or fix something that cannot be fixed.


In June 1986, Sun Ra, a pianist and bandleader with an adopted name, who claimed Saturn as his birthplace but was really from Alabama, and who cloaked his unclassifiably swinging music in celestial references, inaugurated SummerStage, a concert series sponsored by New York's City Parks Foundation.
The next year, SummerStage's headliners included Olu Dara, another inventive musician with an invented name, who proudly claims his actual birthplace of Natchez, Miss., and whose eclectic songs feature earthy details—chickens in the backyard, a peach tree, the dust of unpaved roads. Mr. Dara, who will play a free SummerStage show at Queensbridge Park in Long Island City on Wednesday, has been elemental to the series, which this year celebrates its 25th season with more than 100 events, nearly all free, throughout the five boroughs. A nine-minute version of his "Your Lips," drawn from his 2004 appearance, appears on "Live From the Heart of the City" (Sunnyside), an album marking SummerStage's 20th anniversary.
Olu Dara, seen here performing in 2008, is scheduled to play a free concert in Queens on Wednesday.
If Mr. Dara has marked New York's cultural scene, so has the city shaped him. "I always refer to Brooklyn as my second home," he says, "because it's where I really started my own world." While in the Navy, he met the Yoruba priest who gave him his adopted name (meaning "God is good"). After a final year of service in port at the Brooklyn Navy Yard, he stuck around, working a succession of jobs: delivery driver, nightclub manager, hospital attendant. He held on to his horns and his Gibson and began sitting in with bands. He played in drummer Art Blakey's Jazz Messengers for a year. His purposeful cornet tone soon grew prized, especially by the avant-garde jazz musicians he worked with in the '70s.
"Olu can play with one note what most people can only play in a whole solo," conductor Butch Morris once said.
"I never considered myself a jazz musician," says Mr. Dara. "But I had a jazz sensibility, which I didn't find out until I worked with Blakey." Still, such music-making felt more like work than honest expression, so he formed his own band. It swung hard, drew audiences into a deep blues feeling, and often incorporated theatrical elements: Once, women with washboards, soap and water scrubbed away to the band's rhythms onstage.
If mystery shrouds Mr. Dara's music, it's not just his shape-shifting aesthetic: It wasn't until 1998, at age 57, that he made his recorded debut as a leader with "In the World: From Natchez to New York" (Atlantic). A live album, "Neighborhoods," followed in 2001. "I was just never that interested in recordings," he says. "I've always been after the live thing."
Mr. Dara has inspired many musicians, especially younger ones who, like him, arrived in New York from other places. For singer Cassandra Wilson, who hails from Jackson, Miss., "Seeing someone who was as country as I was and who did not try to hide it was important. Olu never talked to me about what was technically driving the music. He talked about what was emotionally driving the music, what was the story inside."
And his influence extends to his eldest son, Nasir Jones, better known as Nas, the most successful rapper to emerge from the fertile hip-hop scene in the Queensbridge Houses project. On a 2004 single, "Bridging the Gap," which features his father, Nas raps: "Born in the game, discovered my father's music like Prince searchin' through boxes of Purple Rain." A bit later Mr. Dara sings, "Little Africa is where we lived, better known as Queensbridge."
"That's what the neighborhood elders called this place," says Mr. Dara, who now lives in Harlem. When he plays Queensbridge Park on Wednesday Mr. Dara will make a resonant homecoming: to a concert series he's helped shape and the place where he raised his sons, in the city where he found his muse.
Olu Dara is a remarkable musician and a true Renaissance man. I have had the good fortune of both knowing Olu Dara and producing concerts and dances involving him during the 80s and early 90s. Mr. Dara's music incorporates elements of jazz, blues, Caribbean and West African musics. At his core Olu Dara is a storyteller. He can weave a story out of the most mundane daily experiences. I have heard him sing songs telling stories about walking through the mud or I should say sliding through the mud on the way home to see his girlfriend. I have seen him make up songs or lyrics that have arisen from situations that have occurred in a nightclub or dance club setting. I've seen him playing and start to talk to people in the audience and begin to weave them into the fabric of the songs he is performing. In fact one night at the old "Sweet Basil" jazz club in New York, now Sweet Rhythm Olu Dara wove me into a story that he was telling through song. Olu Dara's music relates to everyone. He knows how to reach people on a very basic, human level. He is a very funny and engaging man. Since his early days performing in New York City he has incorporated elements of theater and dance into his musical performances. He worked for years, in collaboration, with choreographer Dianne McIntyre's "Sounds In Motion Dance Company". Mr. Dara has the ability to spontaneously adjust to the movement of dancers while still maintaining a set pace and rhythm for them to work with. Olu Dara is interested in the simple things of life. I have heard him even create stories surrounding the purchase of a chicken sandwich. Olu Dara is an urban griot, a New York sophisticate with roots in the deep South. He worked as a social worker prior to his career as a musician and he brings that knowledge of people to his music.
Do not ever miss the chance to see Olu Dara perform. I have seen many artists perform in my life, from all genres of music, dance and theater. Olu Dara is unique among them. He has recorded two wonderful CDs, "In the World From Natchez to New York" and "Neighborhoods". They are both well worth your purchase.


One of the hottest developments to hit project management in recent years has been recognition of the central role project support offices play in contributing to project success. These offices are substantially different from traditional program offices used on military and construction projects. Their job is not to run projects, but rather to provide an environment that enables project teams to function more effectively. They do this in a number of ways: providing administrative support, establishing methods and procedures, maintaining standards, offering consulting and mentoring services, and helping in training efforts.
Establishing a Project Office explores these and other functions of project support offices and examines how such offices can be established and maintained.
Establishing a Project Office is based on the work of UMT professors Dr. J. Davidson Frame and Mr. Tom Block. Variations of this course have been taught to some 8,000 participants over the past few years. It provides insights based on Frame and Block's work with project offices in more than 200 companies.
To provide students with a thorough grasp of what project offices do and how they can be established and maintained. Both benefits and pitfalls of project offices are described.


text:
Francisca Shirley Ferreira Targino Maia (Caraúbas, 22 de fevereiro de 1967) é uma política brasileira filiada ao Partido Liberal (PL). É a 14.ª prefeita de Messias Targino desde 2017. Foi a 12.ª prefeita do mesmo município entre 2005 e 2012.

É a atual presidente do PL mulher do estado. Durante sua carreira política foi prefeita duas vezes consecutivas da cidade que leva o nome de seu avô, Messias Targino. Sendo novamente eleita dia 2 de outubro de 2016 para o seu terceiro mandato como chefe do poder executivo daquele município.

Carreira política
Filha de Paulo de Freitas Targino e de Maria do Socorro Ferreira Targino, ex-prefeita de Messias Targino, Shirley ingressou na política no ano de 2000, filiada ao extinto PFL, atual Democratas (DEM), como candidata à prefeita de Messias Targino, não obtendo êxito. Iniciou-se na política ao ser eleita prefeita em 2004, com pouco mais de 300 votos de maioria , sendo reeleita quatro anos depois aumentando sua maioria de votos. Nos oito anos em que administrou sua terra natal, Shirley realizou um trabalho inovador e bem sucedido, fato reconhecido em 2010, quando foi eleita prefeita empreendedora estadual e nacional pelo Sebrae. Foi nomeada no inicio ano de 2013 assessora especial I, com lotação no Gabinete Civil da Governadora do Estado. No dia 3 de setembro de 2013 toma posse da Secretaria de Estado do Trabalho, da Habitação e da Assistência Social (SETHAS) do Rio Grande do Norte  do governo Rosalba Ciarlini. Quase seis meses depois no dia 31/03/2014, Targino pede exoneração do cargo de secretária de estado do SETHAS por motivos partidários. A presidente do PR Mulher estava na cota pessoal da governadora Rosalba Ciarlini.

Vida pessoal
No dia 17 de novembro de 2017, casou-se com o então ex-deputado federal pelo Rio Grande do Norte, João Maia em uma cerimônia coletiva ocorrida no município de Messias Targino.

Mulheres do Rio Grande do Norte na política
Prefeitos de municípios do Rio Grande do Norte
Naturais de Caraúbas (Rio Grande do Norte)
Família Maia
Membros do Democratas (Brasil)
Membros do Partido Socialista Brasileiro
Membros do Partido Socialista Brasileiro do Rio Grande do Norte
Membros do Partido Liberal (2006)

redpajama_set_name: RedPajamaWikipedia


text:
You are here: Home / Blog / Mayor's Hispanic Heritage Awards 2014
Mayor's Hispanic Heritage Awards 2014
July 8, 2014 by Sandra Fernandez 2 Comments
Nominations are open for the Mayor's Hispanic Heritage Awards (MHHA). The award is given every year to recognize exemplary Hispanics who have made outstanding contributions toward improving the quality of life within the Hispanic community. The nominations must be postmarked by Thursday, July 31, 2014.
The MHHA Committee will review nomination entries and select the most outstanding nominees to receive the 2014 Mayor's Hispanic Heritage Awards. Mayor Annise D. Parker and the Houston City Council will salute the winners at Council session every Tuesday during Hispanic Heritage Month (September 15 to October 15). All winners will be presented an award at the MHHA reception celebration on October 7, 2014.
The nomination categories for 2014 are:
Art In the Community – recognizes the contribution of an individual whose outstanding efforts has enriched and nurtured the creativity in the Hispanic community through Art programs. Art programs may include visual, music, dance, theatre and quilting/embroidery. In addition to an application, nominations for this award must include a biography highlighting the services rendered by the nominee for which this award is to be presented.
Community Activist – recognizes the outstanding volunteer efforts of an individual dedicated toward improving and educating the Hispanic community thru public and community service. In addition to an application, nominations for this award must include a biography highlighting the services rendered by the nominee for which this award is to be presented.
Education – recognizes an individual who has demonstrated an extraordinary commitment to increasing educational opportunities in academic, healthy living, and sportsmanship, in the Hispanic community. In addition to an application, nominations for this award must include a biography highlighting the services rendered by the nominee for which this award is to be presented.
Youth Activist – recognizes a young Hispanic between the ages of 15 thru 25 for outstanding work in the community thru volunteerism. All community projects must demonstration leadership qualities that inspire our youth to become the future leaders in the Hispanic community. In addition to an application, nominations for this award must include a biography highlighting the services rendered by the nominee for which this award is to be presented.
Lifetime Achievement – recognizes community leaders who have led a lifetime of community service in the Hispanic community. In addition to an application, nominations for this award must include a biography highlighting the services rendered by the nominee for which this award is to be presented.
The 2013 award recipients were:
Lifetime Achievement: Dolores "Lolita" Guerrero
Art in the Community: Macario Ramirez
Community Activist: Mario Martinez
Education: Nicolas Kanellos, Ph.D.
Youth Activist: Nohemi Chavez
Lifetime Achievement: Janie and Frumencio Reyes
Community Activist: Sylvia Louise Gonzales
Education: Rick Cruz
Youth Activist: Genry Santibanez
Art in the Community: Tony Diaz
For more information, including the nomination form, visit the City of Houston's page on the Mayor's Hispanic Heritage Awards.
— Written by Sandra Fernandez
Filed Under: Blog, Community Tagged With: Awards, Hispanic Heritage Awards Honorees, Hispanic Heritage Month
This Week in Blogs — July 27 — Sandra Says says:
[…] Mayor's Hispanic Heritage Awards 2014 || Hispanic Houston […]
Mayor's Hispanic Heritage Awards nominations due Friday, July 24, 2015 – Hispanic Houston says:
[…] post: Mayor's Hispanic Heritage Awards 2014 | Hispanic […]


text:
HISD Celebrates More Students Graduating, Less Dropping Out!
The largest school district in Texas is celebrating success and there are numbers that prove it. News 92 FM's Pattie…
HISD Instructors To Receive Pay Raise
According to reports, the Houston Independent Schools Superintendent Terry Grier has approved a two percent raise for all HISD teachers…
HISD Proposes Raises For Teachers
via: defendernetwork.com Employees in the Houston Independent School District would receive pay increases ranging from 1.75 percent to 2.25 percent…
Seven HISD Schools Receive Donation Of 10,000 Books
In an announcement made Tuesday, seven schools in the Houston Independent School District received 10,000 books, due to a generous…
HISD Says It Will Not Change School Start…
Via News92FM.Com After vocal parents spoke their minds and voiced their opinions and community members shared their thoughts on HISD's…
After vocal parents spoke their minds and voiced their opinions and community members shared their thoughts on HISD's proposal to…
Voter Registration Drive Starts At All HISD High…
via: news92fm.com HISD will launch its Voter Registration Drive at all of the district's high schools Thursday. According to information…
HISD Board Votes To Lay Off School Teachers;…
In a meeting Thursday, the HISD Board voted for a reduction in its workforce. That reduction translates into the laying…
Orlando Riddick Named HISD Chief High School Officer
DefenderNetwork.com reports that former Orlando Riddick has been named chief high school officer of HISD. He will help raise the academic…
HISD Cancels After-School Programs
News92fm.com is reporting that the Houston Independent School District and North Forest ISD have canceled all after-school programs Wednesday due…
Local High Schools Locker Room Thief Arrested!
Police have arrested a man they say may be responsible for a string of thefts at more than a dozen…
Grand Opening Of First HISD All-Girls School!
Senator Kay Bailey Hutchison spoke at the grand opening celebration of a new all-girls school Wednesday morning. The Young Women's…
Houston ISD and City of Houston presents "Back-to-School Fest." Free school supplies, uniforms, immunizations, kid Fun Zone, get info on…
HISD Addresses Magnet School Cuts
Via 39online.com: HOUSTON, TX — HISD is in a tough spot. At stake, 200 million dollars from the state of…
Power Knocked Out To Multiple HISD Schools
HOUSTON (KTRK) — Power outages across the city have left several Houston Independent School District campuses without power this morning.…
Thousands of teaching jobs 'safe' despite budget crisis
HOUSTON – As school districts across Texas brace for state budget cuts, thousands of senior teaching jobs are safe. At…
HISD Celebrates More Students Graduating, Less Dropping…
Seven HISD Schools Receive Donation Of 10,000…


Melbourne, Australia – The intention was good, but the execution? That was terrible. When Australian publication, The Herald Sun, ran a print article on the news DMX had been released from prison, they made one major blunder — they used a photo of Run-DMC legend Darryl "DMC" McDaniels.
Despite the mistake, The Herald Sun has yet to issue any kind of correction on Instagram, Facebook, Twitter or its website.
The "X Gon' Give It To Ya" legend was released from Gilmer Federal Correctional Institution on Friday (January 25) after serving roughly one year for tax evasion. It's unclear when The Herald Sun ran the story.
TR1LL has reached out to DMC and The Herald Sun for comment and is awaiting a response.
In the meantime, check out a few of the reactions below.


text:
Correspondents' Dinner Puts Spotlight on Washington Hilton
Washington Hilton was featured thousands of times over the weekend following the White House Correspondents' Dinner held on Saturday night. In his final speech at the annual Capitol Hill roast, President Barack Obama landed jab after jab on 2016 presidential candidates, national media members and even himself, joking about how much he's aged during his two-term run.
For those of us in the meetings and events industry, the coverage begs for a few answers to questions most of us asked ourselves:
Where is Washington Hilton located?
How much meeting space does it boast?
How many guest rooms does it have?
What other prominent events have been hosted at this property?
The 12-story property opened in 1965, establishing itself as an entertainment center with performances by The Doors in 1967 and Jimi Hendrix in 1968. Washington Hilton has also been a key meetings and events venue. For example, in 1972, it hosted the International Conference on Computer Communications, where Department of Defense technology was introduced and helped established the foundation for the Internet. Besides the White House Correspondents' Dinner, the Hilton annually hosts the National Prayer Breakfast.
Located four blocks from the Dupont Circle Metro station, the Hilton straddles Washington, DC's trendiest neighbors. Besides Dupont Circle, the Hilton is near Adams Morgan, U Street and 14th Street. The fact that you can walk or cab it to and from the Metro station is huge, especially for attendees.
Washington Hilton offers 110,000 sq. ft. of meeting space, including the 36,000-square-foot International Ballroom that regularly hosts black-tie galas for up to 2,670.
White House Correspondents' Dinner
The White House Correspondents' Dinner is limited to 2,600 seats, with news organizations grabbing tables and seats with aggressive strategies. It's one of the top tickets every year, but even more so during the Obama presidency due to his humor and popularity. (There are 260 tables with 10 seats each; the cost of the dinner is $300 per seat, with proceeds benefiting scholarships.)
The Hilton offers more than 1,000 guest rooms and four restaurants. Amenities include a car rental desk, gift shop, multilingual staff and tour desk. Of course, the tour desk is key for attendees hoping to do a little sightseeing while in town.
On Saturday night, all eyes were on President Barack Obama during his final speech at the White House Correspondents' Dinner.
IHG Diversifies Workforce and Provides Opportunities for HBCU Students
Could Gig Workers Solve Hotel Staffing Shortage?
Wellness and Sustainability Top Agenda for Accor Reorganization


text:
[![NPM version][npm-image]][npm-url]
[![Build status][travis-image]][travis-url]
[![Dependency Status][daviddm-image]][daviddm-url]

Bring the power of [React Router](https://github.com/reactjs/react-router) to your SailsJS application. This configurable hook is designed for universal/isomorphic React applications, as the routes are handled both on the server and client.

## Installation
### NPM Install
```sh
npm install sails-hook-react-router --save
```

> This project requires React >0.14 & React Router >1.0 (`npm install react react-router --save`)

## Example Project

And example project for this router can be found [here](https://github.com/teamfa/sails-universal-react-starter).

### Sails setup
Create a `react` config which at minimum returns the resolved path to your React Router exported routes, e.g:

```javascript
// config/react.js
var path = require('path');

module.exports.react = {

  routes: path.resolve(__dirname, './../app/routes')

};

```

> See below config API for the full set of options.

### React Router setup
The routes file now simply needs to return a set of React Router routes. For more information, check the [React Router documentation](https://github.com/reactjs/react-router/blob/master/docs/guides/RouteConfiguration.md). An example of this file:

```javascript
// app/routes.js
import React from 'react';
import { Route, Router, IndexRoute, browserHistory } from 'react-router';

import Layout from './layout';
import Home from './pages/home';
import Articles from './pages/articles';
import NotFound from './pages/404';

export default (
  <Router history={browserHistory}>
    <Route path="/" component={Layout}>
      <IndexRoute component={Home}  />
      <Route path="articles" component={Articles} />
      <Route path="*" component={NotFound} />
    </Route>
  </Router>
);
```

You now need to call the hooks `clientRouter` within your JavaScripts entry point to bootstrap the routes:

```javascript
// app/index.js
import routes from './routes';
import clientRouter from 'sails-hook-react-router/lib/router/client';

clientRouter(
  routes,
  {}, // additional props to pass to router
  // options - see clientRouter docs
  {
    reactRootElementId: 'react-root',
    isomorphicStyleLoader: true
  }
);
```

## API
### Config API
| API | Description | Type | Default |
|---|---|---|---|
| routes | A resolved path to a file which exports a Router component | string |  |
| reloadOnWebpackBuild | Hot reload routes, sails controllers, services etc after every webpack build (only applies in DEV environment). Requires [sails-hook-webpack](https://github.com/teamfa/sails-hook-webpack) to be installed. | boolean | true |
| isomorphicStyleLoader | If enabled, crtitical component styles will be rendered server side. This helps deal with [FOUC](https://en.wikipedia.org/wiki/Flash_of_unstyled_content) issue on client side applications. | boolean | true |
| routingPreference | Which router takes preference on route loading. If two routes on Sails and React are identical, whichever is specified here will be loaded over the other. | string (react/sails) | react |

### clientRouter API
| API | Description | Type | Default |
|---|---|---|---|
| reactRootElementId | The page DOM element **ID** which the app will be rendered to. | string | react-root |
| isomorphicStyleLoader | If enabled, components will be rendered with [style loader](https://github.com/kriasoft/isomorphic-style-loader). | boolean | true |

> **The `isomorphicStyleLoader` must be the same value on both the Sails config and clientRouter - otherwise you'll experience a React invalid checksum warning.**

## License
MIT

## Maintained By
- [Mike Diarmid](https://github.com/salakar)
- [Elliot Hesp](https://github.com/ehesp)

<img src='http://i.imgur.com/NsAdNdJ.png'>

[npm-image]: https://img.shields.io/npm/v/sails-hook-react-router.svg?style=flat-square
[npm-url]: https://npmjs.org/package/sails-hook-react-router
[travis-image]: https://img.shields.io/travis/teamfa/sails-hook-react-router.svg?style=flat-square
[travis-url]: https://travis-ci.org/teamfa/sails-hook-react-router
[daviddm-image]: http://img.shields.io/david/teamfa/sails-hook-react-router.svg?style=flat-square
[daviddm-url]: https://david-dm.org/teamfa/sails-hook-react-router


All weekend I would catch the word "Tokyo" on storefronts and signs. I must admit I did several double takes.
Hope your weekend is/was as gloriously happy as this one was.
This entry was posted on Sunday, July 26th, 2009 at 11:27 pm	and is filed under Japan, Tokyo and tagged with Daikanyama, Tokyo. You can follow any responses to this entry through the RSS 2.0 feed.
and each time it must have been the best sort of surprise.
now talk about a good sign.
and yes. mine was. too.