Huron Consulting Group Announces Clinical Operations Solution Leader | Huron Consulting Group Inc.
CHICAGO--(BUSINESS WIRE)--Jul. 10, 2012-- Huron Consulting Group (NASDAQ: HURN), a leading provider of business consulting services, today announced that Hazel Seabrook has been appointed to lead the Clinical Operations solution within the Company's Huron Healthcare practice.
Seabrook, who is a registered nurse, has more than 30 years of experience in the healthcare industry. Under her leadership, Seabrook has helped many hospitals and health systems realize long-term cost savings to enhance their operations. She joined Huron Healthcare in 2007 as a managing director.
The Clinical Operations solution improves the efficiency of key care and resource management processes in a variety of care settings, including outpatient, emergency and peri-operative. Huron Healthcare solutions create dramatic and substantial improvement that include enhanced consistency and quality of care, reduced lengths of stay and costs per case, decreased variation and care delays, increased revenue, and improved patient satisfaction.


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City of Bellevue, WA Transportation
City of Bellevue
Bike fatality highlights need for caution on roadways
City Clerk's Office News
City Council News
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Published August 21 2019
City strives to provide safe streets for all users
City of Bellevue investigators say last week's fatal car-bicycle collision is a tragic reminder for motorists to always exercise caution and adjust for travel conditions, and for bicyclists not to assume drivers will see them, even if they have the right of way.
Whether you're driving a car or riding a bike, remember to:
Obey traffic signals and signs. Drivers and bicyclists have the same privileges and responsibilities.
Communicate with others. Make eye contact and signal your turns and lane changes.
Use a light at night. For bikes, a white light in front and red reflector or light in back.
Scan the road ahead. At intersections, watch for cars, pedestrians and bicycles.
The city has a bicycle map, which includes extra safety tips for people riding bikes. The National Highway Traffic Safety Administration offers useful tips for motorists.
The crash happened on Northeast Eighth Street on Wednesday morning, Aug. 14, when a motorist turning left from an eastbound lane onto 134th Avenue Northeast struck a westbound bicyclist. The King County Medical Examiner's Office has identified the individual killed as James Ralph, 33, a Bellevue resident.
Bellevue Police say they are investigating several factors as they work to determine causes of the crash. Impairment due to alcohol or drugs has been ruled out. The motorist, a 48-year-old Bellevue woman, told police there was sun in her eyes as she was making the turn.
The incident was the first fatal bicycle collision in Bellevue in at least 10 years and the first traffic-related death on city streets in 2019. Transportation staff are studying the incident to learn more and help prevent future collisions.
"We understand how devastating all traffic collisions can be for friends, family and the community, and we're working together to eliminate them," said Transportation Director Andrew Singelakis.
City departments are collaborating to make roadways safer through its Vision Zero program, an effort to eliminate traffic deaths and serious injuries on city streets by 2030.

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(Louisville to St. Louis)
9 days with American Queen Steamboat Rating: Deluxe
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Day 1: Hotel Stay - Louisville, KY
Enjoy your included, one-night stay at The Brown Hotel in Louisville. The evening is yours to get self-acquainted with this rich in architectural beauty and hidden history.
Our Hospitality Desk will be located in the hotel for your convenience between 3:00 PM and 7:00 PM. It is here that our friendly staff can assist with everything from general questions about your upcoming voyage to reserving Premium Shore Excursions. An American Queen Steamboat Company representative, as well as a local representative, will be readily available to provide you with dining, entertainment, and sight-seeing suggestions so that you may maximize your time in Louisville.
Day 2: Louisville, KY
Departure 5:00 PM
Enjoy Louisville at your leisure. You will board the American Duchess this afternoon to begin your journey.
Day 3: Brandenburg, KY
Once in Brandenburg and Meade County, enjoy the stunning scenery of a city perfectly situated along the Ohio River. The quiet community features two golf ranges, countless outdoor activities, and hunting and fishing abound. The relaxing nature of Brandenburg has pasted its name onto tourist's maps as a quiet, rejuvenating vacation destination. While visiting, discover Brandenburg's rich history winding throughout the Civil War and pay a visit to historic Fort Knox to uncover stories from the past!
INCLUDED SHORE EXCURSIONS
Today we will trace the life of the sixteenth president of the United States - Abraham Lincoln. Beginning at The Lincoln Museum, full of three-dimensional wax figures, life-size dioramas, exhibits, and campaign posters that will build the background of Lincoln's story. From there, we will make our way to Lincoln Square where an impersonator will stand in front of a six-foot brass Lincoln statue and continue telling the story of his life. We will finish the day at the Abraham Lincoln Birthplace National Historic Site, where we will discover Lincoln's humble beginnings.
Day 4: Owensboro, KY
The first European descdant to settle in Owensboro was frontiersman William Smeathers or Smothers in 1797, from whom the Riverfront park is named. The settlement was originally known as Yellow Banks from the color of the land beside the Ohio River. The Lewis and Clark Expedition wintered at what is today's Owensboro prior to departing on their famous travels. In 1817, Yellow Banks was formally established under the name Owensborough, named after Col. Abraham Owen. In 1893, the spellung of the name was shortened to its current Owensboro. There have been several distillers, mainly of bourbon whiskey, in and around the city of Owensboro. The major distillery still in operation is the Glenmore Distillery Company. Owensboro is home to famous actor Johnny Depp, as he is a member of an old and prodigious Kentucky family.
O.Z. Tyler Distillery
The tour of the O.Z. Tyler Distillery covers every aspect of whiskey production, from grain to mash to beer to distillate to barrels of whiskey. A visit to the distillery includes an overview of this patented technology and how it builds upon traditional barrel aging. And after you've seen how it's made, you'll get to taste the end products—O.Z. Tyler Bourbon Whiskey, O.Z. Tyler Rye Whiskey, and O.Z. Tyler Honey Flavored Bourbon Whiskey—in their speakeasy-style tasting room. Finally, no visit would be complete without a stroll through their on-site gift shop! Featuring O.Z. Tyler whiskey products, branded hats, shirts, glassware, and much more, you're sure to find a perfect gift for any bourbon lover.
Western Kentucky Botanical Garden
Conceived from the dust of a cornfield in 1993, the Western Kentucky Botanical Gardens were the idea of a local horticulturalist. Today, six gardens have been established including; a butterfly garden, rose garden, iris garden, herb garden and a fruit and berry garden.
Owensboro Museum of Fine Art
The Owensboro Museum of Fine Art presents traveling exhibitions from major museum, galleries and private collections and rotating exhibitions from the permanent collection. The facility includes two structures listed on the National Register of Historic Sites: the 1909 Carnegie Library and the John Hampden Smith House, a pre-Civil War era mansion which serves as a decorative arts wing. The permanent collection features American, European and Asian fine and decorative arts dating from the 15th century to the present, a stained glass gallery of late 19th and early 20th century German stained glass windows; a collection of contemporary studio art glass; a major collection of American Folk Art with emphasis on the works of 20th century Appalachian artists and craftsmen; and a collection of works by artists and craftsmen with Kentucky connections from the early 1800's to the present.
Owensboro-Daviess County Convention & Visitor's Bureau
Owensboro, Daviess County and the surrounding region are home to an impressive array of well-known celebrities from motorsports, movies, television, sports, music, and government. The Hall of Fame is located in the Convention & visitors Bureau, where visitors can freely browse to learn more about the accomplishments of its members. Visitors may also pick up more information about the history and attractions of the area.
International Bluegrass Music Museum
The International Bluegrass Music Museum is the world's only facility dedicated to the history and preservation of the international history of bluegrass music. Bluegrass is the official State Music of Kentucky. The International Bluegrass Music Museum is located in the River Park Complex at the foot of "the blue bridge" in downtown Owensboro, Kentucky. As you draw near, you'll hear the sounds of bluegrass music emanating from the museum's radio station, RBI, with audio speakers taking the music to the streets. Only a few hundred feet from the museum's entrance, the sounds of music drifts downstream via the mighty Ohio River, the subject of more than a few memorable bluegrass songs.
Day 5: River Cruising
Day 6: Paducah, KY
Paducah embraces their harmonious history between the European settlers and the Padoucca Indians native to the area. The city is located at the confluence of the Ohio and the Tennessee Rivers and because of this, it is often called the Four-Rivers Area due to the proximity of the Ohio, Cumberland, Tennessee, and Mississippi Rivers. This prime location has played a major role in Paducah's history, as transportation was easily accessible – the economy was strong and travelers were frequent!
National Quilt Museum
Celebrating 25 years in 2016, The National Quilt Museum is the largest of its kind in the world. It is the portal to the contemporary quilt experience - exhibits and workshops by renowned quilters who are implementing creative approaches to fiber art. The 27,000-square-foot contemporary structure features three galleries highlighting a collection of contemporary quilts and changing thematic exhibitions that celebrate the talent and diversity of the global quilting community. Workshops taught by world-class fiber art instructors are offered year-round. The Museum Shop & Book Store offers Kentucky Crafted items and quilt-related instructional and collector books.
Floodwall Murals
These incredible works of art span "Wall to Wall" across 3 linear blocks of historic of Paducah. They were started over twenty years ago by Robert Dafford and his team of artists. The walls line the riverbanks of the Ohio River. The murals portray images of Paducah and the river basin's history, and create a nice backdrop for the city, where flooding once was prevalent. (mural books are sold at Yeiser Art Center at 2nd & Broad)
Lloyd Tilghman House
This historic Greek Revival house was built in 1852 for Lloyd Tilghman, a new member of Paducah's community at the time. After the house was completed, Tilghman did not purchase the property. Instead, the builder, Robert Woolfolk became the sole owner of the house and grounds. Tilghman, his wife, their seven children, and five slaves resided in the home until 1861. It was then that Woolfolk and his family moved into the home. Their family was pro-South and proudly flew a Confederate flag causing many uproars in the community and with the Federal Troops who located their headquarters just across the street from the home. Eventually Woolfolk and his family were banished from Paducah and the United States, forced to live in Canada on August 1, 1864.
Paducah Railroad Museum
The original Freight House (across the parking lot from the Museum) was built in 1925 by the Nashville, Chattanooga, and St. Louis Railway. In 1996, the Freight House was sold and the Museum moved to a building one-half block away. Here, learn the history of the railroad and those who used it, explore the authentic train models, and enjoy the memorabilia showcased for guests.
River Discovery Center
In 1988 Mayor Gerry Montgomery and her committee pursued the development of a museum to showcase the Four Rivers Region's maritime heritage. The River Heritage Center was planned in 1992 as the very beginning stages of the mayor's dream. Years later the museum was relocated by Seamen's Church Institute of New York and renamed the River Heritage Museum before finally receiving its current name, the River Discovery Center in 2008. Here explore artifacts, exhibits, and interactive displays that share the history of marine life and the history of the river. Trail Interactive exhibit
The Moonshine Company
Explore, taste, and purchase traditional and international award-winning Kentucky moonshine and moonshine flavors at The Moonshine Company in historic downtown Paducah. Located only blocks from the confluence of the Ohio and Tennessee Rivers, The Moonshine Company offers complimentary guided museum tours and moonshine samples that are distilled on-site in our 108-year-old building. Get a glimpse into the rich Kentucky moonshine history with their collection of historic moonshine stills and purchase that same moonshine secretly produced and bootlegged by our family over 80 years ago to bring home with you!
Day 7: Cape Girardeau, MO
Nestled along the western banks of the mighty Mississippi River lays the city of Cape Girardeau, Missouri. It's a community rich in history and heritage. For more than 250 years, people have been drawn to Cape Girardeau and the river on which it lies. Stroll along the riverfront, where the passion that led Mark Twain to write so eloquently about Cape Girardeau in Life on the Mississippi, the inspiration that Gen. Ulysses S. Grant used to lead with firm conviction as he took command of the Union Army in the historic downtown, and the warmth and hospitality that community founder Louis Lorimier extended to Lewis and Clark while on the journey of a lifetime as they set forth on their Corps of Discovery to explore the Louisiana Purchase will be prominent.
Mississippi River Tales Murals
The Mississippi River Tales Mural is the largest and most dramatic of Cape Girardeau's murals and is located on a portion of the downtown floodwall. Covering nearly 18,000 square feet, this 1,100-foot-long mural features 24 historically-themed panels that vividly portray Cape Girardeau's rich history and heritage; descriptive markers provide an explanation of each panel. The Missouri Wall of Fame Mural features 47 individuals who were born in Missouri or achieved fame while living in the state.
Red House Interpretive Center
The Center commemorates the life of community founder French-Canadian, Louis Lorimier, as well as the visit of Meriwether Lewis and William Clark in November, 1803. The Interpretive Center houses an early 1800s exhibit that reflects the lives of the early settlers of the old Cape Girardeau district. In addition, a rendering of Lorimier's Trading Post displays authentic items that would have been sold at the turn of the 19th century. The gardens on the north side of the house show the types of garden you might have seen in 1803 with flowers, vegetables, cooking herbs, and medicinal herbs.
Old St. Vincent's Church
The Renaissance architecture, referred to as English Gothic Revival style, is not only beautiful but also extremely rare, as very few churches of this style exist in America today. Explore the many artifacts preserved in the church as you admire the arches and woodwork lining the interior of the chapel. Discover this fully restored beauty as it transports you back in time.
Glenn House
Completed in 1883, the Glenn house is a fully restored historic museum in Cape Girardeau, Missouri. It is a prime example of the Victorian period lifestyle including the architecture, furnishings, clothing, and décor. The Glenn House was built for David A. Glenn, who was an influential figure in the city's history. He and his family occupied the home until 1915. Before they vacated the home, it was renovated in 1900 to the Queen Anne Style. The house is listed on the National Register of Historical Places. Many of the furnishings and features of the home have been restored to their original beauty and have been kept authentic to the Victorian time interior.
Holland School of Visual and Performing Arts River Campus
Earl and Margie Holland School of Visual and Performing Arts is composed of departments covering the history and science of art, music, theater, and dance. Visit the beautiful campus and explore the unique styles and subjects taught here. Walk around and discover impressive pieces of art, in many different styles, showcasing the talent and hard work of local students.
Crisp Museum
The Crisp Museum collects in three thematic areas: archaeology, history, and fine art. The Archaeology collection has several collections of prehistoric Native American artifacts, which illustrate aspects of the daily and ceremonial lives of the indigenous peoples who lived in southeastern Missouri from 13,500 B.C. to 1400 A.D., highlighting some very rare and exotic artifacts. The museum's historical collections cover a wide range of artifacts with strengths in the areas of militaria, firearms and their accessories, clothing, and hand tools.
Cape River Heritage Museum
Since its founding in 1981, the Cape River Heritage Museum has focused on local history while preserving a historic building at the corner of Frederick and Independence streets. Located in an old fire house, the museum offers events, tours, and exhibits on steamboats, education, commerce, the Missouri mule, the state flag, the Show-Me slogan, Native American culture, and fire and police memorabilia. Snap a picture of yourself in the model steamboat or in the cab of a tall-ladder fire truck from the 1950s!
Day 8: Chester, IL
Known as the "Home of Popeye", Chester, Illinois is a city rich in history and pop culture. Because creator and writer of Popeye, Elzie Crisler Segar, was born here, the famous characters starred in the show will be seen showcased frequently throughout the town. Stop at the Popeye Character Trail to view granite statues of the characters overlooking the Mississippi or check out America's only Popeye museum and gift shop to take home a souvenir to remind you of your visit to Chester! Spend the day exploring the unique history as you walk through luxurious homes, historical buildings, and museums!
Cohen Memorial Home
The Cohen home is located on a beautiful historical site on Harrison Street overlooking the Mississippi River. Its unusual blue storm windows make it a very visible landmark for boats on the river and travelers approaching the Chester Bridge from Missouri. Built in 1855, it was the home of the William Cohen family who lived there until 1983. The upstairs' bedrooms contain furnishings and collections from several families of Chester including the Cohen family.
The Spinach Can Collectables and Museum
As the only Popeye collectables store and museum in America, this small shop located in Downtown Chester will surely bring back memories of the past as you explore. Walk around the front to see original and rare collectables featuring Popeye, Olive Oyl, Wimpy, Bluto, Swee'Pee, Jeep, and much more. Pick out the perfect unique book, toy, video, postcard, poster, or other memorabilia for someone back home or to keep for yourself. Then head into the back to see some rare and highly sought after Popeye collectables.
The Courthouse and Randolph County Museum
The museum houses permanent displays as well as some artifacts that are temporarily on loan, and it hosts shows and exhibits which showcase specific treasures from the heritage and the long history of Randolph County. In addition, the newly established archives room will enable the museum to properly preserve and store documents, photographs, and other non-displayed artifacts for generations to come. Explore the history of Randolph County through collections of paintings, articles, photos, and artifacts that depict their past.
The Chester Welcome Center offers a lookout point which gives a fantastic vantage point to observe the majestic Mississippi River below. You won't miss this building as a large statue of the iconic Popeye cast in bronze marks its location along the Chester streets. The Chester Welcome Center is located in Segar Park next to the Chester Bridge overlooking the Mississippi River. The new Welcome Center contains restrooms, an information center with displays and a large deck overlooking the Mississippi River and Missouri Bottoms. The bronze statue of Popeye the Sailor Man has been overlooking the Mississippi River in Segar Park for more than 30 years. This is the first of numerous Popeye & Friends Character Trail statues of Popeye characters placed in various areas in Chester.
Day 9: St. Louis, MO
Arrival 8:00 AM
Thank you for cruising with us! We hope that you had a memorable experience and look forward to welcoming you aboard in the future. Enjoy nearby St. Louis at your leisure or consider a Post-Cruise Premium Shore Excursion with airport transfer.
All This Included
LEWIS AND CLARK - The Ohio River served as a thrilling avenue of American Discovery. Explorers became heroes, bigger-than-life exploits were transformed into legends, and American identity was forever tied to the West. The wilderness region is just as evocative today with an abundance of history to explored. Delve into the early days of American exploration and acquaint yourself with the heroic Lewis and Clark Expedition. Special guest historians will be onboard to provide you with a sense of the challenges and triumphs that the nation's early pioneers faced.
Complimentary Hop-On Hop-Off shore excursions in each port of call
Complimentary hotel stay the night before your voyage – includes breakfast, taxes, porterage and transfers to the vessel
All onboard meals, including both fine dining and casual cuisine
Complimentary wine and beer with dinner
Complimentary cappuccino, espresso, specialty coffees, tea, bottled water and soft drinks throughout your voyage
Gracious service from a friendly, all-American staff
Acclaimed entertainment worthy of Broadway
Our own dedicated fleet of deluxe motorcoaches
Accommodations on this Tour
Cabin onboard American Duchess
Cabin upgrades are available.
Itineraries are subject to change.
Single occupancy cabins are available.
Port Taxes are additional and not included in the prices shown above.
Please ask your Vacations To Go travel counselor for more information.
* The prices shown are U.S. dollars per person, based on double occupancy, and subject to availability. Prices quoted for land/cruise arrangements are subject to increase without notice. Once we have received your deposit, land/cruise prices are guaranteed. Air prices quoted via phone or email are subject to increase and are guaranteed only from the time that full payment is received. Also, air prices or air promotions mentioned on this site or on the phone do not include baggage fees imposed by airlines. Sorry, we are unable to offer air from countries other than the U.S. However, for those international customers who are able to arrange their own transportation to the trip origination city, we are able to offer the land/cruise portion of the package at the price quoted.
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Atlanta, 30319
6701 Discovery Blvd.
Home > Georgia > Atlanta > 30319
Atlanta, Georgia, 30319.
We are an Atlas Van Lines Agent in Atlanta, Georgia, 30319.
Estimated Population:
10.4 square miles
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Peachtree Golf Club
achtree is a very exclusive classic Robert Trent Jones and Bobby Jones design in northeast Atlanta that enjoys large pine and dogwood trees, Augusta-like bunkers, and rolling terrain with azalea flowers. The conditioning is impeccable in every sense of the word with every blade of zoysia grass seemingly perfect in health and length. The course is bordered by busy streets and development, but you would never know it due to the surrounding trees that screen the views and buffer the noise so effectively. The design elements and feel of the course draw a lot of similarities to Augusta National which shouldn't be a big surprise given Bobby Jones' influence on the layout. There are only five fairway bunkers found on the course paired with the comfortable driving corridors combine to create Peachtree's reputation as a very playable course. Hundreds of trees have been removed from property which has opened up the feel of the interior holes and delivered some welcome vistas across the course. The tips play more than ten strokes stiffer than the forward tees and delivers a stout, but fair, test to any golfer. The tee box may be the only flat lie you'll find during the day and your caddy will help you read the large undulated greens that roll fast and true. In conclusion, Peachtree is a pure golfing experience that features a quaint pro shop and clubhouse. It is the type of course that you could play everyday and never grow tired of it and the design is such that you should be able to keep big numbers off your scorecard but will still have a difficult time breaking par. The terrain and conditioning at Peachtree are perfect for golf and deserves its place among the Top 100 finest tracks in the country.
Founded in 1835, Oglethorpe University unites a close-knit campus community with big city culture and opportunities. Today, Oglethorpe enrolls 1,385 students, representing 37 states and 31 countries. We've also been ranked:
Top 20 "Best Buy School" (Fiske Guide to Colleges).
#33 among America's most entrepreneurial colleges (Forbes).
#48 out of 1,223 for "Best Value" nationwide (USA Today/Wall Street Journal).
#56 out of all liberal arts colleges in the nation for our contribution to the public good (Washington Monthly).
#148 among America's best national liberal arts colleges (US News and World Report).


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Chinese Leader's Visit to Paris Seen as Test for European Unity
26 Mar 2019, 07:06 GMT+10
PARIS - Chinese President Xi Jinping has been treated to a sumptuous dinner near Nice and an official welcome by his French counterpart at the Arc de Triomphe in Paris not to mention a 17th-century French translation of Confucius.
But Xi's three-day visit to France, which began Sunday, promises to be a much bigger challenge than his past two stopovers. The Chinese leader coasted on the first leg of his European tour, marked by getting Italy on board his 'Belt and Road' project, and a friendly welcome in the tiny Riviera principality of Monaco, which agreed to let Chinese technology company Huawei develop its controversial 5G telecommunications network.
His third leg will test both Xi and French President Emmanuel Macron, who has cast himself as one of Europe's strongest champions. For Xi, analysts say, the goal is not just to broaden Chinese economic ties, but also political clout in Europe in the face of other major global competitors. For Macron and his allies, it means coaxing a fractured bloc to speak in a single voice when it comes to doing business with China.
'It's in the Chinese interest that Europe is not divided, that we remain a leading partner,' Le Journal du Dimanche newspaper wrote, summing up what it described as Macron's thinking about China's relations with the European Union, its biggest trading partner.
Monday's agenda included inking energy, food and transport deals, followed by a state dinner for Xi hosted by Macron at the Elysee presidency. Besides trade, the two leaders were also expected discuss climate change, with Macron reportedly seeking greater Chinese cooperation to counter Trump administration skepticism.
The bigger business comes Tuesday, when German Chancellor Angela Merkel and European Commission President Jean-Claude Juncker join Macron in Paris for talks with Xi.
The French president has already set the tone, declaring Friday 'the time for European naivete is over' a sentiment echoed by fellow EU powerhouse Germany.
'We want a relationship based on reciprocity,' Merkel said. 'If one side has access, then the other side should, too.'
But European solidarity may be undermined by more than a dozen individual trade and investment agreements struck between China and EU member states, from Poland and Portugal, to Greece and the Czech Republic.
'If Paris, Brussels and Berlin are on the same page, it's not certain that everyone will follow them,' France's Le Monde newspaper wrote. 'Scandinavian countries are reticent ... those in the south Italy, Portugal, Greece ... need Chinese investment.'
Indeed, earlier this month, Malta signaled it might be the next contender.
'One has to be wary of any country, especially with political ambitions or any sort of ambitions,' Maltese Finance Minister Edward Scicluna told CNBC, 'but that's life.'
Also described as the new Silk Road, China's strategy of infrastructure development and investments now spans more than 150 countries. Chinese yuan have helped to bankroll new trains, roads and ports around the globe crucial additions, especially for developing nations, and key instruments to expand Beijing's economy and global leverage.
Win-win deals or are they?
China calls the initiative a 'win-win' deal. But critics note the infrastructure projects have indebted some African and Southeast Asian nations and rendered strategic assets, including ports in Djibouti and Greece, essentially under Chinese control.
Already weakened by Brexit and internal political divisions, Europe's ability to handle China in a unified way may be put to the test at an EU-China summit next month.
The European Union has drafted an official strategy calling on member states to pressure Beijing for greater accountability and transparency in its business dealings. Yet that might be undermined by another reality; China's effectiveness 'at dividing and conquering EU member states by targeting them individually,' wrote University of Bristol East Asia expert Winnie King in The Conversation.
Francois Godemont, an Asia expert at the Montaigne Institute in Paris, believes Xi's priorities on this trip are not only economic, but also to 'disarm' a skeptical Europe and further distance Brussels from Washington before more U.S.-Chinese trade talks next month.
'Seen from China, trade deals are a footnote,' he added in an interview Monday with France-Info radio.
Another French analyst, Sylvie Kauffman, argues Xi's visit underscores a much bigger threat as other powers including Russia and the United States also seek to undermine European unity.
'Europeans need more than a wake-up call,' Kauffman wrote in the The New York Times. 'They must decide whether they can contemplate the prospect of their continent being cut up piece by piece by competing bigger powers, or whether they want to regain enough collective strength and common sense to control their own destiny.'


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William Montacute, Another Royal Favourite (2)
Second and final part (first part) of my post about Sir William Montacute, one of the three great 'favourites' of Edward II in the middle years of his reign.
It was in 1316 that William, who had recently distinguished himself on the campaign against Llywelyn Bren in South Wales, really came to prominence. On 20 August that year, the king granted him the marriage of Joan de Verdon, eldest daughter and co-heiress of her recently-deceased father Theobald, and William arranged Joan's marriage to his eldest son John. (Theobald de Verdon's widow, Edward II's niece Elizabeth de Burgh, was in fact pregnant, though Edward couldn't have known that at the time, and gave birth in March 1317 to another daughter, so Joan remained an heiress.) On or around 18 November, Edward appointed William steward of the royal household, replacing John Cromwell, and in January 1317 William contracted to serve Edward for life, in return for an annual salary of 200 marks. [1] As William was already married, he could not compete with his fellow royal 'favourites' Roger Damory and Hugh Audley for the two greatest prizes at Edward II's disposal in 1316/17, the hands in marriage of his nieces Margaret (de Clare) Gaveston and Elizabeth (de Clare) de Burgh, though the marriage of his son John to one of the Verdon heiresses was a sign of great royal favour.
The appointment as steward gave William constant access to the king, which translated into a great deal of political influence. William was, with Roger Damory and Hugh Audley, said by the Flores Historiarum to be "worse than Piers" (Gaveston), and was also said to be deliberately preventing the king from reaching an accord with his powerful cousin the earl of Lancaster for his own selfish ends (see my posts on Damory and Audley for more details). William and the others actually admitted this in June 1318, during the negotiations which were soon to lead to the Treaty of Leake between Edward and Lancaster; they acknowledged that Lancaster had refused to come to the king and make his peace "by reason of us" (par encheson de nous). [2] In July 1318, Lancaster accused William, and Roger Damory, of trying to kill him. [3] Was that true, or only Lancaster's paranoia? It's hard to say, but clearly William, Damory and Hugh Audley were widely seen as Lancaster's enemies and as standing in the way of the very necessary reconciliation between the two most powerful men in the country. The Vita Edwardi Secundi points out in July 1318, when Lancaster failed to attend a meeting of the king's council in Northampton, that the earl refused to attend because he "counted all the aforenamed [the three favourites, the two Hugh Despensers and the earl of Surrey] as his deadly enemies...[who] intrigued against the earl as best they could." [4]
To cut a very, very long story short, William's influence on the king was preventing accord between Edward and his powerful cousin, and could not be allowed to continue. After the signing of the Treaty of Leake and the 'kiss of peace' between Edward and Lancaster, William was removed from his post as steward of the royal household and replaced by Bartholomew, Lord Badlesmere, and was appointed steward of Gascony instead on 20 November 1318, replacing Antonio di Pessagno of Genoa. [5] Although this appointment was a great honour, it was also - and certainly William knew that it was - intended to keep him well away from Edward and to prevent him exercising any influence over the king. (One historian has described this excellently as William being "kicked upstairs," but unfortunately I can't find the reference at the moment. I think it was Seymour Phillips, possibly in his article in the BIHR about the 'Middle Party' and the Treaty of Leake negotiations.) Understandably, perhaps, William was in no great rush to leave to take up his new job: he and his household were still in England on 5 March 1319. [6]
William lasted less than a year in his new position, and died in mid or late October 1319 (his date of death is sometimes given as 18 October, but I don't know the source for that), probably aged forty or thereabouts, and was buried in Gascony. He was survived by his widow Elizabeth de Montfort, sons William, Simon and Edward, and half a dozen or so daughters - among them a future earl, a future bishop, two abbesses and a prioress. Edward II - who, I assume, mourned the sudden passing of a close friend - had heard of William's death by 6 November, on which date he ordered the escheator to take William's lands in Somerset, Dorset, Devon, Lincolnshire, Norfolk, Oxfordshire, Buckinghamshire and Hertfordshire into his own hands. William's eldest surviving son William was still under-age and became a royal ward, and was called a 'king's yeoman' in May 1321 when Edward granted him "wardship of two parts of the lands late of his said father..." (a favour, as William was still under-age, and received the rest of his inheritance on turning twenty-one). [7] He accompanied Edward II to France in June 1320, when the king had to pay homage to his brother-in-law Philip V, and remained close to Edward during the rebellion of 1321/22, being appointed mainpernor for the rebel Edward de Stredelynge. [8]
It's interesting to speculate what would have happened had Sir William Montacute (the elder) remained in England and survived past 1319: would he have turned against the king, infatuated with Hugh Despenser the Younger, as his fellow 'favourites' Roger Damory and Hugh Audley did in 1321, or remained loyal, as his son did? At any rate, his friendship with and loyalty to Edward II and his son's friendship with and loyalty to Edward's son Edward III - one wonders how successful the young king's coup against Roger Mortimer in October 1330 would have been without the younger William - were to make the Montacutes one of the most prominent families in England in the fourteenth century.
1) Calendar of Patent Rolls 1313-1317, pp. 535, 609; T.F. Tout, The Place of the Reign of Edward II in English History, second edition, p. 315.
2) Flores Historiarum, ed. H.R. Luard, vol. iii, p. 178; J.R.S. Phillips, Aymer de Valence, Earl of Pembroke 1307-1324: Baronial Politics in the Reign of Edward II, p. 164.
3) Phillips, Aymer de Valence, p. 131; J. R. Maddicott, Thomas of Lancaster 1307-1322: A Study in the Reign of Edward II, p. 224.
4) Vita Edwardi Secundi, ed. N. Denholm-Young, p. 87.
5) Foedera 1307-1327, p. 377; Patent Rolls 1317-1321, pp. 243, 257.
6) Patent Rolls 1317-1321, pp. 311, 312, 314.
7) Calendar of Fine Rolls 1319-1327, pp. 7, 56.
8) Patent Rolls 1317-1321, p. 452; Fine Rolls 1319-1327, p. 293.
Posted by Kathryn Warner at 2:02 pm
Makes you wonder what exactly were the problems between William (and Damory and Audley) and Lancaster.
Monday, 17 January 2011 at 16:49:00 GMT
Anerje said...
William, to me, appears to be the less well-known of Edward's favs. It is intriguing, as you say, to think what would have happened had he lived - which side would he have been on? Was there any jockeying for favour between Damory, Audley and Montacute?
Gabriele, I think William and the others just did their best, or rather their worst, to prevent any reconciliation between Ed and Lanc (and possibly even made it worse), because Lanc, if reconciled to the king, would have them removed from court.
Thanks, Anerje! I love those 'what ifs'! Yes, I'm sure there was a lot of jockeying for power, and plenty more when the younger Despenser began his rise at court, but unfortunately it's not visible in the sources (but would make great fiction...! :)
Tuesday, 18 January 2011 at 07:54:00 GMT
Susan Higginbotham said...
I'm so glad he left his son behind after his death to help Edward III oust Mortimer!
Hehe, me too, Susan! ;-)
Hugh Despenser Seizes Tonbridge Castle
It's That Man Again! Some Primary Sources Relating...


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text:
Critical Care > Intensivists
Sleep Deprived-Patients in ICU May Fail to Get Off Ventilation
Pathological wakefulness in ICU could predict ventilator dependence
by Salynn Boyles Salynn Boyles, Contributing Writer March 02, 2019
Attempts to wean intubated, critically ill patients off mechanical ventilators were less successful when the patients exhibited atypical sleep or pathological wakefulness, researchers reported.
The findings suggest that sleep deprivation may be a risk factor for weaning-failure, and that monitoring sleep patterns prior to weaning attempts could be a successful strategy for identifying mechanically ventilated patients who are not ready to breathe on their own, reported Laurent Brochard, MD, PhD, of the University of Toronto and St Michael's Hospital in Toronto, and colleagues, in the American Journal of Respiratory and Critical Care Medicine.
To measure sleep in critically ill patients, researchers combined standard polysomnography with a novel sleep index, developed by co-author Magdy Younes, MD, PhD, of Sleep Disorders Centre in Winnipeg, Canada, which utilized a portable sleep diagnostic device rating deep sleep (score of 0) to full wakefulness (score of 2.5).
Brochard explained to MedPage Today that disordered sleep and sleep deprivation are common among ICU patients on mechanical ventilation.
"A number of studies have shown that sleep architecture is very abnormal in these patients," he said. "Most lose the circadian rhythm, and experiencing no REM sleep is also common."
He said these sleep issues could play a role in delirium, which is also common among patients on mechanical ventilation, and in neurocognitive dysfunction after an extended ICU stay.
Brochard noted that while several earlier studies have linked disordered sleep to more difficulties weaning patients off mechanical ventilators, the impact of ICU stays and sleep deprivation on liberation from ventilation is poorly understood.
"Successful separation from mechanical ventilation necessitates an adequate response from a number of physiological systems, all of which could be impaired by sleep deprivation," he said, adding that the current study was conducted to determine whether assessment of periods of sleep and wakefulness in the hours before attempted ventilator weaning would predict success or failure.
Electroencephalogram (EEG) data recorded during a 15-hour period preceding the spontaneous breathing trial (SBT) was analyzed to assess patient ability to breathe without mechanical ventilation.
The researchers hypothesized that patients with atypical sleep or pathological wakefulness were more likely to fail an SBT. In addition to conventional scoring, they used a digital scoring system that produces a number of EEG markers -- odds ratio product (ORP) and spindle characteristics -- that are relevant to identify pathological wakefulness and atypical sleep, as well as possible cerebral pathology.
"ORP is highly correlated with arousability and is therefore a valid index of sleep depth. One of its advantages is that it can distinguish between different levels of wakefulness since the awake range extends from 2.5 (full wakefulness) to 1.8 (epochs still scored wake but contain some sleep features). This would make it particularly useful for identifying Pathological Wakefulness in which wake EEG contains some sleep features," the researchers wrote.
They analyzed data from 37 mechanically ventilated patients treated at three Toronto-area hospitals, scheduled for a SBT, to assess their readiness for breathing on their own.
All patients had undergone polysomnography for 15 hours prior to the SBT test, and 31 had the ORP analysis.
The SBT test was successful in 19 of the patients, but eight did not have their breathing tubes removed due to other clinical issues. SBT was unsuccessful in 18 patients.
Classical sleep stages determined solely by conventional sleep scoring guidelines were not associated with success or failure of SBT.
"The high prevalence of stages referred to as pathological wakefulness or atypical sleep made the classical scoring of sleep of limited value and the distribution of sleep stages did not differ," the researchers wrote.
Longer duration of full wakefulness (ORP score >2.2) was highly correlated with successful SBT and extubation and the degree of wakefulness was clearly lower in patients who failed SBT based on ORP assessment.
In addition, poor correlation between sleep depth in the right and left brain hemispheres was also highly predictive of SBT failure.
"The lack of synchronicity between the two parts of the brain seen in some patients was a complete surprise to us," Brochard said.
He noted that correlation of sleep depth between the left and right brain hemispheres is a characteristic of sleep studies in normal participants and those with chronic sleep disorders.
The finding that nearly half the patients in the ICU study exhibited discordant sleep depth between the two brain hemispheres was characterized as "remarkable and highly significant" by the researchers, and highly predictive of SBT failure.
"Although it is not possible at present to determine why SBT failure and poor right/left correlation are associated, the finding that a poor correlation is associated with severe pathological wakefulness suggests a possible link," they wrote.
They added that this phenomenon of regional differences in sleep -- some parts of the brain are asleep while others are awake, and often called uni-hemispheric sleep -- is seen in dolphins and related mammals, as well as in birds that must go for long periods without sleep.
"It is possible that this primitive adaptive mechanism is reactivated in humans under conditions where natural sleep is deemed by the individual to be unsafe," the authors wrote.
Study limitations included those "intrinsic" to the classical sleep scoring process, they noted. Also, "Assessment of hemispheric EEG correlation with the [right/left] ORP was not correlated with specific neurological investigation but there were no clinical grounds to suspect the presence of primary brain disease," the authors stated.
The study was funded by the French Intensive Care Society, the European Respiratory Society, the 2015 Bernhard Dräger Award for advanced treatment of ARF of the European Society of Intensive Care Medicine, the Assistance Publique Hôpitaux de Paris, the Fondation pour la Recherche Médicale, and MitacsGlobalink Sorbonne Universités.
Younes disclosed relevant relationships with Cerebra Health. Brochard disclosed holding the Keenan Chair in Critical Care and Acute Respiratory Failure, and relevant relationships with Covidien, Air Liquide, Philips, and Fisher Paykel. Co-authors disclosed support from, or relevant relationships with, Pulsion Medical Sysem, Lungpacer, and Mahidol University.
American Journal of Respiratory and Critical Care Medicine
Source Reference: Dres M, et al "Sleep and pathological wakefulness at time of liberation from mechanical ventilation (SLEEWE): a prospective multicenter physiological study" Am J Respir Crit Care Med 2019.
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Tiny flower girl dress of Ruffle Fabric: Tutorial!
You've got to check out this amazingly fun and easy project I just did for our flower girl at the wedding in a couple of weeks. I only recently discovered Ruffle Fabric, this great site with tons of cute already-ruffled fabric in many colors and types, and it was perfect for the flower girl's dress! So happy to have them as a sponsor!
They have all kinds of choices but I went with lavender my 2-year-old flower girl's dress. Inspired by fancy girl's dresses on J.Crew Crewcuts and other stylish kid companies, I thought it would be fun to do a ruffled skirt and a smooth bodice of a contrast fabric.
It was amazing how easy this dress was to make--maybe it's because I don't often make children's clothes (pretty much never) and, um, they go together way faster than clothes for me! Duh. And the fit is less critical since children are little barrels with limbs and their clothes don't need to fit like a glove.
Anyway, want a tutorial for how to use this great ruffle fabric for a little girl's fancy dress? Here goes!
I used a regular pattern for the bodice, Simplicity 2430. I wanted something a little 50's vintage-ey as well as cool and classy J.Crew-ey, so I gave her puff sleeves.
Cut out the bodice and get your piece of ruffle fabric. Depending on the height of the child, you'll probably only need about 1/3 of a yard!
Okay, now you have all your pieces cut out.
Assemble the bodice as you would any other dress. Leave the back open and don't install your zipper or buttons yet.
Pin right sides together the selvages of the fabric, aligning your ruffles so they all lay pointing down.
Starting 4-5" down, sew together.
There's no real need to press that center back seam you just made open or to one side, since it's a stretch fabric and will do what it wants anyway.
Now, along the top edge of the skirt (the one with the 4-5" opening), run a long stitch with tight tension and gather the skirt.
Right sides together, pin your gathered skirt to the bodice. I like to try to match the center front of the skirt (as it lays flat, using the center front of the bottom of the skirt as a guide) to the center front of the dress so you know your gathering is even all around.
Again you don't really need to press since the woven nature of the bodice will dominate the loosely woven knit of the top of the ruffle fabric, so your seam allowance should point down toward the skirt.
Now, install your zipper or other closure as you would any dress.
To match my silk flowers and everything, and to give it some more detail, I made a silk flower for the waist of the dress and sewed it to a pin back. Then I pinned it to the waist of the dress--hope it's in the right place, but we can move it around or take it off and put a sash or something on it for another occasion later! Easter, maybe?
Seriously, this took me like an hour. So fast and easy! And cute. Check out Ruffle Fabric and look at all the cute colors and ideas there... great idea for a quick and simple project!
That is adorable! Great use of ruffle fabric!
Your flower girl is going to look soooo puuuurrrty! I really like this dress, and it does not look like it only took you an hour to make!
Awww how lovely. I saw this exact fabric here in my local fabric store (im in the UK) and thought how lovely it was. My daughter loves ruffle/rah-rah skirts so I best get making!!
Really cute dress! I love making kid's clothes bc it's so much faster and easier! I always opt to make stuff for my daughter over me!
I absolutely love this! I want one!
Ooooh you should totally sell these, I would buy them for my flower girls!!!!


text:
Patriots showing interest in veteran TE Delanie Walker
Back in 2010, the Patriots drafted two young tight ends – Rob Gronkowski and Aaron Hernandez. To help them get acclimated to the NFL, the team brought in veteran tight end Alge Crumpler, who was 33 and had four Pro Bowls to his resume.
Crumper only caught six passes that season, which happened to be his last, but he certainly helped the young players in their first NFL season.
Fast forward to 2020 and the Patriots are in a similar situation after drafting Devin Asiasi and Dalton Keene in the third round. According to ESPN, the Patriots are showing interest in veteran Pro Bowl tight end Delanie Walker.
Walker, 35, is a three-time Pro Bowler. He spent the last seven seasons in Tennessee. Last year, he caught 21 passes for 215 yards and two touchdowns. An addition like this one would make a lot of sense for the Patriots.
First and foremost, the Pats lack a veteran at the tight end position. On Sunday, Matt LaCosse opted out. That left Ryan Izzo, 24, as the most experienced tight end on the roster. He made his NFL debut last season and ha six career catches. Izzo 'leads' a group with four other rookies – Asiasi, Keene and undrafted free agents Rashod Berry and Jake Burt.
Adding Walker to this mix would make a ton of sense. He could help the rookies and provide some much-needed leadership to this position group and locker room. Although his numbers last season weren't eye-opening, it still would've led all Patriots tight ends from 2019.


Glendale's Budget is in for a Tough Time.
After continually using the GWP as a piggy bank to draw upon for budgetary shortfalls, Glendale's Power Plant is now in need of $500 Million re-power. $500 Million that will be borrowed to pay for the re-power. Eight out of the nine generation units are well beyond their useful life and have been operating for years spewing pollutants into the air. Yet each year $20 Million continues to be dutifully transferred to the General City Fund to maintain employee benefits at the expense of GWP assets. Given that GWP is in such dire condition, serious concern exists on where the $20 Million for next years budget is going to come from.
More pressure is mounting on the city's budget from CALPERS that administers the city employees pensions. Legal challenges are mounting that questions the entitlement of benefits to employees and the City's continued obligations to fund them. This caused CALPERS management to reduce the payback period for unfunded pension obligations from 30 years to 20 years to ensure it can collect all it can before changes in the law. Changing the amortization years from 30 years to 20 years creates a 27% increase in the annual payments the city is required to pay back. Funds that the city does not have.
The budgetary pressures on Glendale have created a great rush upon which the city wishes to implement this $500 million re-power. The proposed re-power is controversial due to the continued use of petroleum based fuel and does not take adequate consideration for new and renewable sources of energy and power management technologies. Opponents of the re-power question the environmental impact on health and the wisdom of investing $500 million in antiquated technologies without a comprehensive study for renewable alternatives. There seems to be a huge rush to implement this re-power despite large opposition from the public. An opposition that calls on GWP to slow down and consider renewable options.
Given the above constraints, Glendale will certainly be challenged to balance the budget. However, fattening up the piggy bank with $500 million will sure go a long way in continuing the illusion of a balanced budget if only it can be done fast enough.
Roland Kedikian has been a practicingbankruptcy attorney since 1997 focusing exclusively in bankruptcy law. He provides debt relief services to individuals and businesses experiencing financial hardship. With offices in Glendale and Arcadia, he serves the southern California communities and cities within the San Fernando and San Gabriel valley regions. Prior to transitioning into law, Roland worked at the Jet Propulsion Laboratory as an engineer where he helped develop vibration suppression methodology for use on satellite systems. Roland subsequently transitioned into law where he obtained certification as a patent attorney. Roland received his bachelors of science in aerospace engineering in 1993 from Cal Poly Pomona and his JD from Southwestern University School of Law in 1997.
2016 Year in Review of the GCBG Activities.
Carmel Partner's proposed 285 Unit Development Would Exacerbate Glendale Quality of Life and Housing Problems.
Next story The Elephant in the Room…or, How Could Something So Simple Be Overlooked??


Thanksgiving Point is located in Lehi, Utah, and has beautifully manicured gardens and walkways. Beautiful arbors and architecture make for stunning images. This area is by the water tower and contains the Rose Gardens, the Logia, and the small waterfall. There is a $75 fee to shoot here and a $30 travel fee. There is also the Thanksgiving Point Gardens which is about a 1/2 mile away. See that location here.
Address: 3003 N. Thanksgiving Way, Lehi, Utah 84043 Purchase the photo pass at the Water Tower Plaza. We will meet at the Water Tower.


text:
Domagoj Surać (* 4. März 1984 in Zadar) ist ein kroatischer Handballspieler.

Karriere
Der gebürtige Jugoslawe spielte bis zur Saison 2007/08 bei RK Gortan Zadar  bis er zur Saison 2008/09 zu EMC-Split wechselte. Nach nur einer Saison in der ersten kroatischen Liga wechselte er zur Saison 2009/10 zum italienischen Erstligisten HC Teramo Handball. Nach Ablauf der Saison führte ihn seine Karriere wieder zurück in seine Heimat zu RK Gortan Zadar. Zwischen 2011/12 und 2014/15 lief Surać für Union Leoben in der Handball Liga Austria auf. 2015/16 wurde er vom Ligakonkurrenten Moser Medical UHK Krems verpflichtet. Bereits im März 2016 verkündete der Alpla HC Hard die Verpflichtung des Kreisläufers für die Saison 2016/17, damit spielte der Kroate nur eine Saison in Krems. 2016/17 sicherte sich der Rechtshänder den österreichischen Meistertitel. Nach der Saison 2017/18 wurde der Vertrag des Kroaten nicht verlängert. Für die Saison 2018/19 kehrt der Kreisläufer zu seinem Jugendverein RK Zadar zurück. Im Januar 2019 wurde der Rechtshänder von JS Cherbourg verpflichtet.

HLA-Bilanz

Erfolge
 1× Österreichischer Meister 2016/17

Weblinks
 HLA-Kader von Union Leoben

Einzelnachweise

Handballspieler (Kroatien)
Handballspieler (Italien)
Handballspieler (Handball Sportunion Leoben)
Handballspieler (UHK Krems)
Handballspieler (Alpla HC Hard)
Kreisläufer
Kroate
Geboren 1984
Mann

redpajama_set_name: RedPajamaWikipedia


text:
A statisztikai hipotézisvizsgálatokban az egy- és kétoldalas próbák különböző megközelítései egy paraméter statisztikai szignifikanciájának meghatározásában.
A kétoldali próba abban az esetben megfelelő, ha a becsült érték lehet nagyobb és kisebb is, mint a referenciaérték, például ha egy tesztkitöltő teljesíthet a történelmi átlag alatt és felett is. Az egyoldali teszt akkor alkalmazandó, amikor a becsült érték a referenciaértéktől csak egy irányban térhet el, például ha arra vagyunk kíváncsiak, hogy egy gép több mint 1%-nyi hibás terméket hoz-e létre. A próbák neve a mintavételi eloszlás oldalaira utal, ahol az értékek gyakorisága igen kicsi, és gyakran a nullához közelít.

Alkalmazási területei
Az egyoldalas próbát olyan aszimmetrikus eloszlásokban alkalmazhatjuk, amelyeknek csak egy oldala van, például a khí-négyzet eloszlásban, vagy alkalmazhatjuk egy kétoldalú eloszlás (például normális eloszlás) egyik oldalára, ha megjelöljük a próba irányát. Kétoldalas próbát csak abban az esetben alkalmazhatunk ha az eloszlásnak két oldala van, így mindkét irányban lehet szignifikáns értékünk.

Ronald Fisher megközelítése szerint a nullhipotézis elvethető, ha a statisztikai próba p-értéke megfelelő mértékben szélsőséges, és ezzel a véletlen eredmény magasan valószínűtlennek ítélhető. Egy egyoldalas próbában a 'szélsőség'  iránya a próba elvégzése előtt dől el, tehát vagy kellően kicsi az érték, vagy kellően nagy – a másik irányban lévő értékek nem tekinthetők szignifikánsnak. A kétoldalas tesztekben mindkét irányban szignifikáns lehet a szélsőséges érték. Egy kétoldalas statisztikai próba adott adatokkal és szignifikanciaszinttel egy ezzel megegyező egyoldalas tesztben ugyanazokkal az adatokkal, vagy kétszer szignifikánsabb (a p-érték fele) – ha az adatok a tesztben meghatározott irányban vannak –, vagy egyáltalán nem szignifikáns, hiszen a tesztben meghatározott iránnyal ellentétesek az adataink.

Például, ha pénzfeldobáskor azt akarjuk tesztelni, hogy a pénz cinkelt-e a fej irányába, az egy egyoldalas próba, amelyben ha minden pénzfeldobásunk fej, az adatok magasan szignifikánsak lennének, míg ha minden pénzfeldobásunk írás lenne, akkor nem lenne szignifikáns az eredményünk. Ezzel szemben, ha azt teszteljük, hogy cinkelt-e akármelyik irányba, az egy kétoldalas próba, amelyben mind a fej, mind az írás extrém gyakorisága szignifikanciát jelezne. Az egészségügyi kutatásban, ha arra vagyunk kíváncsiak, hogy a kezelés eredménye jobb-e a véletlenszerű eredménynél, akkor egyoldalas próbát csinálunk; a véletlenszerűnél rosszabb is szolgálhat fontos adatokkal, ebben az esetben kétoldalas próbát kell alkalmaznunk, amelyben azt vizsgáljuk, hogy eltér-e a kezelés eredménye a véletlenszerűtől.

A pénzfeldobásos példa
Pénzfeldobáskor a nullhipotézis Bernoulli-próbák sorozata 0,5-ös valószínűséggel, egy olyan véletlenszerű változót (X) magába foglalva, amely vagy 1 (fej), vagy 0 (írás) értékeket vehet fel (röviden, a nullhipotézisünk az, hogy 50-50% esély van mindkét értéket felvennie a változónknak).  Ha arra vagyunk kíváncsiak, hogy a fej irányába van-e cinkelve a pénzünk, egy egyoldalas próbát kell alkalmaznunk – tehát csak nagy fej-többségben lesz szignifikáns a próbánk. Ebben az esetben, ha az adathalmazunk 5 fejből áll, 1-es mintaátlaggal, amelynek a valószínűsége 1/32 = 0,03125 (5 egymás után pénzfeldobás két lehetséges kimenetellel – ((1/2)^5=1/32). A p-érték tehát körülbelül 0,03 lenne, amely szignifikanciát jelez, ha a 0,05-ös határértékkel számolunk. Ezzel szemben, ha azt teszteljük, hogy a pénzérme bármelyik irányba cinkelve van-e, egy kétoldalas tesztet alkalmaznánk,  amelyben 5 fej (1-es mintaátlag) és 5 írás (0-ás mintaátlag) is ugyanannyira szélsőséges lenne, ebben az esetben a p-érték 2/32 lenne (0,0625), amely már nem számít szignifikánsnak a 0,05-ös határértékkel számolva.

Története

A p-értéket Karl Pearson vezette be a Pearson-féle khí-négyzet próbában, ahol a p-értéket egy adott értéktől való eltérés valószínűségeként határozta meg. Ez egy egyoldalas meghatározás, mert a khi-négyzetes eloszlás aszimmetrikus, amely vagy nullát, vagy egyet feltételez, tehát az eloszlásnak csak egy oldala van. A próba az adataink eloszlásának egy hipotetikus eloszlásra való illeszkedését vizsgálja.

Az egyoldalas és kétoldalas tesztek elkülönítését Ronald Fisher népszerűsítette a nagy sikerű Statistical Methods for Research Workers című könyvében, ahol leginkább a normáleloszlásra alkalmazta, amely egy szimmetrikus eloszlás két oldallal.

Fisher az oldalak kiszámításának fontosságát hangsúlyozta a The Design of Experiments (1935) című könyvében is, ahol elmagyarázta, hogy egy specifikus adathalmaz lehet kellően valószínűtlen, de ha az a kérdésfelvetésünkkel ellentétes irányú, nem lehet szignifikánsnak tekinteni.

Jegyzetek

Fordítás

Statisztika


Countless people are currently smoking marijuana for recreational purposes, to alleviate chronic health conditions, and to naturally address issues like anxiety or depression. Now that many states have legalized marijuana, this drug is easier to access than ever before. Moreover, weed prices have stabilized and consumers can choose from a much broader range of options. Despite the many positive changes that affect weed users, however, companies still frown upon marijuana use among their employees. As such, many people undergo mandatory drug testing as part of the normal hiring process. Some companies are also required to perform drug testing on a regular basis, as a way of mitigating workplace accidents and other problems related to on-the-job impairment. Although you might not ever arrive at the workplace high, this drug testing is still necessary and virtually unavoidable. The good news is that there are a number of tips, tools, and resources that you can use to ensure that you never get a positive.
There are no sound arguments against the fact that abstinence is always the best method of passing a drug test. Apart from false positives, which do not occur as often as people think, there's no way to test positive for drug use if you have not been using drugs in any way at all and have not been in an environment in which people have used drugs. There are, however, a few effective cleansing methods that you can put to use in order to clear your system out. But, you should bear in mind that these will only be effective if you're willing and able to do your part – which usually means abstaining throughout the cleansing process.
For marijuana users, cleansing is rarely an effective method when there are less than two weeks to get the job done. Unlike other illicit substances, marijuana is fat soluble and stored in the individual's body fats. People with high body fat percentages and those who have a habit of using the highest potency weed products they can find, tend to have the hardest time cleansing over a very short period. Drinking lots of cranberry juice, apple cider vinegar, or water just won't work. With weed, it is important to burn off the fat stores that contain THC or to give the body sufficient time to metabolize the THC that's been stored in these cells.
Taking zinc is considered to be an effective way to block positive results in this testing, but many testing facilities are now looking for excessive amounts of zinc in urine samples. If you have a marijuana test to take and have been using a fairly high-potency strain in recent weeks, you'll want to purchase the best synthetic pee you can find. You can use this in place of a natural urine sample so that there's absolutely no risk of the lab finding THC in the liquids that you've submitted.
When it comes to using synthetic urine to pass a drug test, there are still a number of important considerations to make. To start, you want to make sure that urine sampling is the type of testing that you're required to undergo. It makes absolutely no sense to invest in the best synthetic pee if you'll be asked for a sample of your saliva instead. Keep in mind that third-party testing facilities often perform urine or hair analysis, while small-sized companies that perform testing onsite analyze saliva via low-cost cheek swabbing sets.
Another vital factor to consider is whether or not the testing environment will make it easy for you to submit synthetic urine. For instance, you may have near-constant supervision while producing your urine sample. A lot of companies do this to ensure that people are not removing bags of pre-collected urine from the legs or inner thigh areas. There are other measures that are taken to ensure that false samples are not submitted. For instance, testing facilities make sure that urine samples are the appropriate temperature and that these are reflective of the individual's natural characteristics, such as his or her gender and expected hormone profile.
With these things in mind, the best synthetic pee products are rarely standalone solutions. These come as part of comprehensive kits instead. When shopping for these products, look for kits that include warming devices, and genital prostheses for natural-looking elimination.


We love a tonal look, but choose your pieces with care – you don't want the outfit to melt together. The trick to making each piece stand out is to mix materials and textures. Wear a fluffy fur – this season's trend piece – with classy pants and a soft, loose-fit t-shirt.
When dark, fall-like mornings approach, our outfit inspiration tends to run a little low. Enter the statement jacketA jacket is a mid stomach length garment for the upper body. A jacket typically has sleeves, and fastens in the front or slightly on the side. A jacket is generally lighter, tighter-fitting, and less insulating than a coat, which is outerwear. Some jackets are fashionable, while others serve as protective clothing. – perfect for turning a simple, all-black look into an eye-catching on-trend outfit. Our favorite styleStyle is a manner of doing or presenting things, especially a fashionable one. for the season is checkered and bulky – balance the silhouette with classics pumps (worn with socks on cold days) or a sleek sock boot.
If you don't have a classic, blazer-style jacket in your wardrobe, it's time to invest in one. Wear with a shiny patent skirtA skirt is a tube- or cone-shaped garment that hangs from the waist or hips and covers all or part of the legs. The hemline of skirts can vary from micro to floor-length and can vary according to cultural conceptions of modesty and aesthetics as well as the wearer's personal taste, which can be influenced by such factors as fashion and social context. Most skirts are self-standing garments, but some skirt-looking panels may be part of another garment such as leggings, shorts, and swimsuits. and roll up your jacket sleeves to create a boxy silhouette.


Today, pause many times to feel Love's hug. Rest in that hug. For that moment, give up all worries, knowing that they are held by Love. Feel Love's affection and acceptance flowing into you.
Today, know that you are already worthy, lovable, and whole, just as you are, just as Love made you.
This way, you don't burden your work unnecessarily with your need for it to reflect back to you a version of yourself you can admire, with a need for it to give you a sense of purpose and make you feel needed and successful. Likewise with your relationships.
Instead, know your work and relationships as gifts - all of you learning together, all of you opening your hearts to learn what Love might teach you.
Today, trust the threads in your life: the continuities, those things you love, the divine patterns.
How to help more wisely.
In her book on creativity Big Magic, Elizabeth Gilbert shares this quip from columnist Katharine Whitehorn: "You can recognize the people who live for others by the haunted look on the faces of the others."
Those of us who feel deeply empathetic and responsible for others - or who define our worth by our ability to be capable and helpful - sometimes need to pull back a little on our "helping." Think about the kinds of support others have offered you: what has strengthened and sustained you and what has annoyed or undermined you? Respect that others can solve their own problems. Actively recognize others' strengths and capacities. Admit that you do not fully understand another's situation. Understand that support comes from many directions - you are not its only source. Recognize the people grow and change on their own timing and often on surprising trajectories. Humbly recognize your own need for help and accept it.
This, of course, does not mean that we are not generous and kind and present - only that we admit how much we don't know about what others need, we communicate respect for other's innate worth and capacity, and we watch that we are not serving others for our own ego-needs, asking them to give us what is not their responsibility to give.
The book of James promises that "If any of you is lacking wisdom, ask God, who gives to all generously and ungrudgingly, and it will be give you."
Today, humbly ask for wisdom. Ask for wisdom in your relationships. Ask for wisdom in your work. Ask for wisdom in your words. Ask for wisdom in your actions and reactions. Ask for wisdom in your pacing. Ask for wisdom in your priorities. Ask for wisdom in your small, daily decisions and in your large life decisions. Ask for wisdom, and then feel a deep, calm trust that your request is being answered right now. Trust. Be patient, and take the next step that feels right.
We often resist structure as something that limits us or squashes inspiration. But structure can be not just beautiful, but essential: think of the structure of a bridge or a building, the structure of a skeleton or a leaf.
Today, feel the power of Love revealing and enforcing useful structures that support your well-being - and the well being of those you love. Acknowledge Love at work when you get an idea for how to better organize your day, your time, your possessions, a creative project, a work project. Acknowledge Love at work when you see ways to create routines that better support your priorities. Listen. Love's ideas for structures in your life may be different from what you assumed, may run counter to organizational and self-help advice. These ideas are designed specifically to support your individual stability, joy, growth, and prosperity.
To expand your prayer, feel the power of Love revealing ethical and effective systems and structures to families, organizations, and governments.


The best advice you can give a young player is for them to play like Morphy and Tarrasch, and to play the openings they played. But, once your play has reached a certain standard, you need to appreciate more the complex and sometimes contradictory nature of chess. Then you are ready to look at Larsen's games.
He was clearly the one of the strongest players in the world in the 'sixties and 'seventies, and captained the Rest of the World team against the Soviet Union in 1970. And he also has a bold spirit, excellent fighting qualities, superb technique and a fresh approach to the openings. You can learn a lot from a man like that.
Larsen is also a wonderful annotator, and worth reading for his notes alone: for example, his book of the 1978 Karpov-Korchnoi match is excellent reading, and a far cry from the hurried hackwork that usually follows a championship match. His games collection is a joy from start to finish - frank, witty, thorough and the games are full of delights.
Not a move to play against everybody: 3...Nxe4! 4. Qh5! may be required.
"Most masters have no high opinion (of Bird's Opening), but I chose it for the very reason that they do not play it and do not know it. I know it quite well, and have many original ideas. Now I challenge Spassky with it; let us see what ideas he has to show."
"If (Black) forgets to do something active, then he will be slowly strangled. Playing this system means that I force myself to play aggressively!"
Black waits for the Bc1 to move before playing Nh5.
White gets nervous and flees the centre, but this is out of the frying pan and into the fire.
"A move full of fighting spirit and self-confidence. As a matter of fact I believe that Bronstein knows more about the King's Indian than I do but -- come out and fight!"
The next few moves should be showered with annotation marks, but which ones?
A fabulous ding-dong of a game. Donner annotated this game twice in two days, once giving 22.Kxf2? then again with 22.Kxf2! But if he knew about 25...Nxc4, maybe he would have annotated it a third time, and found a third typographical symbol. Larsen thought that Donner had a lot of courage to correct his first analysis so quickly; I agree.
"I used to have Black in this position!"
"I have several times used this position to illustrate how the right move is sometime found through elimination."
"We perceive after a careful consideration of the evolution of the chess mind that such evolution has gone on, in general, in a way quite similar to that in which it goes on with the individual chess player, only with the latter more rapidly."


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Policy Analysis for California Education
Continuous school improvement & support
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PACE/USC Rossier Annual Voter Poll
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Getting Down To Facts II
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How School Districts Craft Coherence Towards Continuous Improvement
Newcomer Students' English Language Development
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Does Reclassification Change How English Learners Feel About School and Themselves?
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Eric Grodsky
About PACE
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Professor, Department of Sociology,
Eric Grodsky is professor of sociology and educational policy studies at the University of Wisconsin—Madison. His research focuses on inequality in higher education, including work on affirmative action; socioeconomic inequalities in college attendance and completion; changes in the role of merit in these processes over time; and the role of college-readiness information in high school students' college preparatory behavior. Grodsky is also involved in a study of the relationship between adolescent sexual activity and educational attachment and achievement; work on the effects of college remediation on persistence and time to degree; and research on the determinants of entry into and persistence in science, technology, engineering, and mathematics at baccalaureate institutions. He is codirector of the Madison (Wisconsin) Education Partnership. He has taught at the University of Minnesota and the University of California, Davis. He received his PhD in sociology from the University of Wisconsin—Madison.
Contributing topics
Publications by Eric Grodsky
State Standards, the SAT, and Admission to the University of California
Like most other universities in the country, the University of California (UC) requires that students submit scores from either the SAT or ACT exams as part of their application package. These tests have their origins in the efforts of a handful of…
Postsecondary Preparation and Remediation
Examining the Effect of the Early Assessment Program at California State University
This paper investigates how participation in the Early Assessment Program (EAP), which provides California high school juniors with information about their academic readiness for college-level work at California State University campuses, affects…
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Famous Philosophers
Philosophical Problems & Questions
Enlightenment Philosophers List
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Pragmatism: Definition and Philosophers
Philosophy of knowledge
Skepticism Philosophy Summary
Women Philosophers List
Philosophy Dictionary
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French Quotes, Quotes
Tocqueville Quotes: Politics, freedom and society
1 Best Quotes by Alexis de Tocqueville, political philosopher
2 Tocqueville and freedom:
3 Tocqueville and Equality:
4 Tocqueville and individualism:
5 Tocqueville and political power:
6 Tocqueville and the Revolution:
Best Quotes by Alexis de Tocqueville, political philosopher
Alexis De Tocqueville is the thinker of modern democracy, representative in large and multi-cultural States. Regarded as a sociologist, Tocqueville had actually conducted a descriptive philosophy of liberal democracy. Tocqueville's opinion are keen on main democratic items : public opinion, association, tyranny of the majority, individualism. Tocqueville, for all these reasons, should be read again.
Tocqueville and freedom:
– "People want equality in freedom and if they can not get it, they still want to slavery"
Tocqueville and Equality:
– "There is indeed a male and legitimate passion for equality which excites men to want to be all strong and valued. This passion tends to elevate the rank of major small, but it also occurs in the human heart taste depraved for Equality, which is low in wanting to attract high levels, and reduces men to prefer equality in servitude to inequality in freedom "
– "When inequality is the common law of a corporation, the strongest inequalities do not strike the eye, and when everything is pretty close to that level, the slightest injury. That is why the desire equality always becomes insatiable as equality is greater "
Tocqueville and individualism:
– "Individualism is a feeling which disposes each citizen thought to isolate themselves from the mass of his fellows so that, having created a small company for its use, he willingly leaves society at large itself "
– "Individualism is of democratic origin, and it threatens to grow as conditions equalized"
– "Individualism is a recent expression of a new idea was born. Our fathers only knew about egoism"
– "The Passion of material well-being is essentially a passion of the middle classes"
Tocqueville and political power:
– "Above the citizens arose immense and tutelary power, which takes upon itself alone to secure their enjoyments and watching over their fate. It is absolute, minute, regular, provident, and mild"
– "The fear of disorder and the love of well-being are gradually democratic nations to increase the attributes of the central government"
– "One point does make me believe that a Liberal government, energetic and wise, can never get out the votes of a nation of slaves"
– "I hope the legislature takes care of itself deprive the men of their independence, they are almost happy '
– "The State represents more daily, next to, around, over each individual to assist, advise and constrain"
Tocqueville and the Revolution:
– "All that the Revolution did, would have done, I doubt not, without her, she was a violent and rapid method with which it has adapted to the political state social state, the facts to ideas, laws manners "
– "In democratic societies, the majority of citizens do not see clearly what it could win a revolution, and she feels at every moment, and a thousand ways, it could lose"
– "The great revolutions that succeed, by eliminating the causes that produced them, thus become incomprehensible by their own success"
Cite this article as: Tim, "Tocqueville Quotes: Politics, freedom and society, April 24, 2012, " in Philosophy & Philosophers, April 24, 2012, https://www.the-philosophy.com/tocqueville-quotes.
Thomas Jefferson Quotes
Balzac Quotes: Human Comedy and Passions
Voltaire Quotes: Religion, Politics and Pacifism
Nietzsche Quotes
Bourdieu Quotes : Capital, Distinction and Habitus
If god does not exist everything is permitted – Dostoevsky
American, Philosophers
Ayn Rand and Objectivism
What is philosophy*?
Etymologically, philosophy means love of wisdom. Before being a field of study, it is above all a way of seeing the world, of questioning it. The founding principle of philosophy is perhaps the astonishment, source of the questions. Then, philosophy related to the activity of argue rationally about astonishment. * We have published more than 500 articles, all seeking directly or indirectly to answer this question. Know first of all that there is no single answer to this question.
Major Philosophers
Socrates, Plato, Aristotle, Epicurus, Descartes, Spinoza, Rousseau, Kant, Hegel, Nietzsche, Marx, Sartre, Heidegger, Tocqueville
The-Philosophy helps high-school & university students but also curious people on human sciences to quench their thirst for knowledge.
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Microsoft Lumia650 is now available for just $119.99 on Carphone Warehouse
Lumia 650 is now available for a more cheap deal in the UK. Microsoft recently revealed their premium looking affordable Windows 10 Mobile powered smartphone, the Lumia 650. Several retailers are already selling the new device in different corners of the world.
Now Carphone Warehouse is selling the device for just $119.99. Which is one the cheap deals you can get for the Lumia 650 if you are a UK resident. Here are some of the key features of this smartphone:
5-inch display (1280 x 720 pixels, 297ppi, AMOLED, ClearBlack, Gorilla Glass 3)
8MP rear camera (f/2.2 aperture), 5MP front camera (f/2.2 aperture)
Qualcomm Snapdragon 212 (Quad core, clocked at 1.3 GHz)
16GB of internal storage (with microSD support)
6.9mm thick, weighs only 122g.
GSM, WCDMA, LTE support
Glance screens support
Comes in White and Black
The next update to Google Chrome will block autoplay videos with sound
Windows 10 Build 17120 now available with fixes and improvements
Notepad ++ Microsoft Store version available now
Windows 10 SETS UI is all set to make the next paradigm shift in computing
Mozilla brings back Google as the default search engine for its Firefox browser
Facebook kills Messenger day to merge it with Facebook Stories


^The "Luke" necklace is in the middle photo and the third photo I am wearing the 4XL monogram w/16" chain.
Use code FORYOU for 40% off almost everything on the site.
Use code LOVEMOM for 30% off site wide. If you have a Loft card, you get 40% off the site.
Use code MOM for 40% off the Gap website.
Buy one item get 20% off – or buy 3 items and get 30% off! Use codes SAVE30, SAVE 25, SAVE 20!
Get $170 off Vitamix blenders! + A few other random sales!
There are no real sales going on site wide for Nordstrom BUT a few of my favorite items are on sale! Like THESE wedges I've been wearing a lot, THESE little lace-up sandals are for $49, THESE Stuart Weitzman wedges, and THESE Tory Burch flip flops.
Also, there are some cute tops and dresses that are marked down. I have THIS top in 3 colors and it is on sale for $27. And THIS bell sleeve top is $26. Okay – last thing – I love THIS ruffled sleeve sweatshirt, on sale for $41!
^The white tunic in the first photo is the tunic I have in 3 colors.
Below are links to shop clothing & shoes on sale – there are TONS of good items that are included!
Hi Emily! Is The luSh top you are wearing in the top left pic white or ivory? I love it and have been looking For white for months, and its never an option. I WONDERED if the one you are wearing is really the ivory one? Also, love your blog and wanted You to know i'm a maternal/child rn and teach breastfeeding Every day and i seriously thought it was the hardest thing with my first. TotallY worth it , but DEFINITELY not as easy as i thought it would be.!!😳 You are doing great and look so lovely WITH a baby in Your arms!!😊 Happy mothers day!!


WordPress is an ideal solution for a business website, it's easy to manage, offers huge flexibility on a solid platform.
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Nourished by the Blood
By twos and tens, by hundreds and thousands they fell and their blood soaked into this sacred soil.
By squads and companies, by battalions and regiments they fell in combat and their bodies were laid beneath this sod and their blood mixed with the soil.
In drops and trickles, in pints and by the heart-full their blood was spilled and spread across the red clay dirt of Dixie.
In battles and skirmishes and engagements; in hospitals, homes and tented camps, illness took them and their bodies were laid to rest in the soil of the Southland.
On the fields where they fell, in church yards, by the road sides they were interred. In a land scarred and riven by war the soil was billowed with the graves until the surface of the land was like the ocean on a windy day - roll after roll after roll.
And their bodies became one with the loamy land of Dixie.
The rains fell and the occasional snow covered the land so that moisture penetrated the earth, carrying their blood deep into our fields.
Not just the soldiers, either. Poverty, disease, starvation carried off women, even children. Much of the condition causing their deaths was a deliberate ploy induced by a cunning and heartless invader who hated the South and all things Southern, who hated out of envy and who superciliously sought for a false moral high ground to justify their immoral actions.
So the blood of innocents was shed, the lives of the blameless were taken. Their forms went beneath the sod. And those forms mingled with the soil, the soil on which we now stand.
The seasons passed and trees dropped their leaves. The leaves crackled and crumbled, turning to humus and enriching the soil, mixing with their blood.
Those who survived that holocaust tilled the earth, planted and tended the seed, and lo, the crops grew and matured and they were nourished by the produce of the soil, a soil enriched by the blood.
Now we stand, in our day, sprung from their loins, though at a remove in time. And we till the soil and eat of the fruit of the land, the land which holds their bodies, the land which is soaked with their blood.
Intolerant and angry voices are today raised against those people, our people, the people of our past.
In the name of "diversity" exclusion is practiced and practiced against us because of our sires and dames.
In the name of "tolerance" intolerance is shown towards the South and all things Southern.
Our children are taught [in government schools] more about the 5th of May [Mexican Cinco de Mayo] than about 21 July, 1861 [Battle of First Manassas]. They should be taught about both battles against imperialist invaders.
They are given the words to folk songs from every part of the world but can attend kindergarten through 12th grade and 4 years of college without hearing the soul stirring strains of "Dixie." They should know the songs of their own forebears.
They are taught the holidays and heroes of all the cultures in the nation but are never told January 19th is the birthday of Robert E. Lee. They should know the heroes of their own people.
The voice of John Brown, the axe murderer from Kansas, the terrorist of Harpers Ferry, is mild compared to some of the voices which speak out against the South today.
The politically correct have come to teach us their ways. They scorn us for being what we are. But they will fall. When Political Correctness is but the unpleasant distant memory of a forgotten fad, the starry blue cross of St. Andrew on a red field will still wave over a proud, brave and free people.
We cannot be worn down, we cannot be overpowered because our fields bring forth food which contains not only nutrients for our bodies but which replenishes our spirits and our souls.
We are different, we Southerners, because we are nourished by the remains of heroes. They have enriched our soil. We are nourished by their blood.
And, strengthened by that nourishment, we do not forget, we do not turn back, we do not surrender.
Those who wish to say us "nay" may do so. Those who wish to forget the past will do so. But may God have mercy on their shriveled up little souls. We hold fast to our Confederate heritage for we are nourished by the blood of heroes and martyrs.
That blood is within us. We cannot fail to remember them!
Deo Vindice


Summary of Presentation: There are no good biomarkers for the early diagnosis of cholangiocarcinoma. CEACAM6 is an extracellular protein involved in cell signaling. When overexpressed in gastrointestinal malignancies such as pancreas and colon cancer, it is associated with worse prognosis. Therefore we hypothesized that if CEACAM6 can be detected in the bile of patients of cholangiocarcinoma, it may serve as an early marker of disease. Bile was collected from patients undergoing resection for cholangiocarcinoma and from patients with benign biliary disease. Biliary CEACAM6 levels were determined by enzyme-linked immunosorbent assay and Western blot. Higher CEACAM6levels were found in the bile of patients with bile duct cancer especially extrahepatic cholangiocarcinoma. Future studies with a larger number of patients are needed to validate these results.


iPhone 7 and iPhone 7 Plus owners have had more than a year for the wounds of losing the 3.5mm headphone jack to heal. But for people upgrading to a new model from an older iPhone like the iPhone 6s or iPhone 6, the pain of losing the headphone jack is fresh. Luckily, there's a tiny little accessory that will make the pain go away. The Ombrace Lightning Splitter lets you connect a Lightning charger Lightning headphones (or 3.5mm headphones with the dongle that comes in your iPhone box) at the same time, so you can power up your iPhone and listen to music on the go. If you have an iPhone X, iPhone 8, iPhone 8 Plus, or even any of last year's iPhone models, definitely check it out.
With this accessory, you won't have to worry about compromised sound quality on your audio, either. It's accurately restores the 24 bit/48 KHz digital audio stream output of the iPhone through the Lightning port, with no damage to the original high-quality music.