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Inovio Coronavirus vaccine (INO-4800) Phases, Availability, Cost
The coronavirus pandemic has recently hit its 21 million marks. This ongoing pandemic has taken around seven hundred thousand lives. Search to find the vaccine to fight this pandemic has been ongoing since the day WHO declared it to the Public Health Emergency of International Concern. Among all this, various companies were able to develop various candidates to combat this pandemic. One such company is Inovio Pharmaceutics. Inovio Pharmaceuticals, a biotechnological company, is in the process of developing a vaccine INO-4800 against COVID-19. INO-4800 is a DNA based vaccine having the plasmid pGX9501, encoding for the entire length of the spike glycoprotein of COVID-19. It has demonstrated long term protection in non-human subjects challenged with the COVID-19 virus 13 weeks after immunization. Its response was mediated by the memory T and B cells. According to the Inovio pharmaceuticals, INO-4800 is the only one among nucleic acid-based vaccines that are stable at room temperature and does not require freezing for transportation or storage, which is a crucial feature for mass immunizations.
Inovio Coronavirus vaccine(INO-4800) Phase Results
Pre-clinical Study
INO-4800 was designed within three hours on January 10th, 2020, by Inovio, using its unique DNA medicines platform technology to match the virus's DNA sequence after the release of the genetic sequence of the COVID-19 by Researchers in China. Pre-clinical testing and clinical trial designing were started between January 10th to 23th,2020 and its data is available in the journal Nature Communications. The pre-clinical testing was done on mice and guinea pigs. Mice and Guinea pigs were given 2.5-µg and 10-µg. The antigen mediated and T-cell immune responses were measured during the preclinical studies. The vaccine showed not only the virus-neutralizing activity but it also produced antibodies in the animals The pre-clinical testing showed promising results that lead to further studies. INO-4800 was also studied in larger animal rhesus macaques. Macaques were given two doses of 1-mg INO-4800 with a 4-week gap.
The animals were challenged with the live COVID-19 virus for more than 3 months after the immunization with INO-4800. The INO-4800 was able to provide long-lasting protection for up to four months. The INO-4800 was able to reduce the viral replication in the lungs and nasal pathways thereby decreasing the severity of the disease. The result of the study is published in the peer-reviewed and non-peer-reviewed journal. The preliminary study results make INO-4800 a potential candidate for the COVID-19. This is the first vaccine that has provided protection through the memory immune response in non-human subjects. INO-4800 has become the participant of the non-human primate study conducted by the US Operation Warp speed due to its encouraging interim study results. The Chief Executive Officier and President of Inovio, Joseph Kim, had said,
"All other previously reported NHP vaccine protection studies actually challenged the animals at the peak of their immune response. Our study demonstrates that INO-4800 could provide protection in a more real-world setting, where vaccine-generated memory immune responses protected NHPs for more than 3 months (13 weeks) from the last vaccination. Given the importance of protective antibody and T cell responses, this study gives us more confidence as we continue to advance INO-4800 in the clinic. We believe INO-4800 holds significant potential to help address this global public health crisis."
Phase I & II clinical trial
In April 2020, the Inovio started its Phase-I of the human clinical trials. The trial was open-labeled and carried out at the University of Pennsylvania, Pennsylvania, and Center of Pharmaceutical Research in Kansas City,Missouri. The first phase clinical trial involves 40 participants between the age of 18-50 years, each of which are given two doses of INO-4800 with a four-week gap. The doses of 1 mg and 2 mg INO-4800 were given with the help of CELLECTRA®. The first phase involved the assessment of the safety and immunogenicity profile of INO-4800 in humans. Three volunteers were excluded during the study entry as they tested positive due to prior infection before the study enrollment and one volunteer left the study due to unknown non-clinical reasons. Both the humoral and cellular immunes responses were studied through immunological assays.
At week 6, overall immunity was found in 94% of the volunteers. The ten adverse effects reported were of grade 1 severity, with redness at the injections site being the most common. There were no serious adverse effects found till week 8 and it was found to be safe and well-tolerated in humans. The first phase trial now has been expanded to the older population over the age of 65 years. The Inovio is aiming to publish the study results in a peer-reviewed journal. In June 2020, Inovio initiated its Human clinical trials in South Korea.
The main purpose of this trial is to determine the safety and immunological profile of INO-4800 by the use of CELLECTRA® 2000 for electroporation and administration of INO-4800 intradermally. The trial will include healthy individuals between the age of 19 to 50 years, later the trial will include an additional 120 individuals between the age of 19 to 64 years. On July 15th, 2020, the Seoul National University has administrated the first dose of INO-4800 to a 40-year-old patient. The 2/3 efficacy phase is expected to be initiated after the approval from the regulatory authority in the summer because of the positive results from the first phase. The Vice President of R&D, Kate Broderick, had said,
"As we eagerly anticipate initiating a Phase 2/3 efficacy trials this summer, an animal challenge is currently the closest thing we have to testing a vaccine's efficacy when confronting a live virus. We are very encouraged with the duration of protection that INO-4800 demonstrated in this NHP study and look forward to reassessing its impact on durability of response at 12 months out from our other ongoing non-human primate and animal challenge studies.In addition to safety and efficacy, it is essential that any vaccine targeting SARS-CoV-2 generates a relevant durability of response.A vaccine that only provides protection for a very short period of time is not going to realistically solve the problem of this pandemic."
Inovio Coronavirus vaccine(INO-4800) Mechanism
Inovio DNA vaccines can produce balance antibodies and T-cell responses. Inovio is using its DNA medicine platform for the optimized delivery of the plasmid directly into the cells. It is brought by the use of a small handheld device called "CELLECTRA®" which is patented to the Inovio. This device uses an electrical pulse to open a small pore in the cell for the entry of plasmid. Inside the cell, the plasmid starts replicating. The plasmid assists the cell to produce the targeted antigen to strengthen the immune system. This antigen then initiates the desired T-cell and antibody-mediated immune response. The INO-4800 targets the major spike surface proteins of the COVID-19 virus which results in the production of B-cells and T-cells. The antibodies that recognize the virus are produced by B-cells while the virally infected cells are killed by T-cells which also supports B-cells.
Studies have demonstrated that INO-4800 can provide long term protection due to its vaccine generated memory immune response which has protected non-human subjects since their last vaccination for 13 weeks. The T-cells produced after immunization can control the severity of the disease. After the initial dose, the antibodies and the T-cells lasted for more than 4 months in the non-human subject's blood. The antibodies level and T-cell responses were found to be significantly greater than the recovered and recuperating COVID-19 patients. The study data support the INO-4800 ability to reduce viral replication and viral shedding in the nasal cavity. It not only produces responses against the early virus but also against the G614 mutant variant which is now dominant.
Inovio Coronavirus vaccine(INO-4800) Availability
In March 2020, Inovio prepared 3000 INO-4800 doses for clinical trials on humans in the US, South Korea, and China and had started to prepare its plan for mass manufacturing. Inovio has been receiving generous funding from various resources after its successful and positive study results. The US's Department of Defence has funded 71 million dollars to Inovio for the mass manufacturing of its trademark smart device CELLECTRA® 3PSP and purchasing of CELLECTRA® 2000 devices, which are used for the delivery of INO-4800 intradermally into the body cells.
The Coalition for Epidemic Preparedness Innovations (CEPI) and Bill & Melinda Gates Foundation also has given an extensive amount of funding to Inovio. INO-4800 has also been selected for the US's Operation Warp Speed program whose aim is to provide a safe and effective COVID-19 vaccine by January 2021. Furthermore, Inovio is planning to provide one million doses by the end of the year with the use of its current capacity and resources. German Manufacturing partner, Richter-Helm has provided additional capacity which will be helpful in mass manufacturing of the vaccine. Inovio is still looking for additional resources and funds to expand its capacity.
Inovio Coronavirus vaccine(INO-4800) Cost
The Inovio has not released any information regarding the cost of the vaccine. Since the vaccine is still in clinical trials, it is too early to make any comment on the cost of the vaccine.
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What are BAP and AIS Club?
The members of Beta Alpha Psi are offered a unique networking opportunity. At each of our meetings, future employers present on a topic, opportunities available at their firm, and allow members to ask questions. We also host many social events that allow interaction amongst classmates and professionals in a casual setting. Recruiters of BGSU students often look for "Beta Alpha Psi" on resumes, as they know the prestige our group has earned Nationally and the commitment it takes to become a member.


6" Dia. stainless steel disc used for stacking molds, compatible with S4 Mold (#33203) and S6 (#33204).
Lipase Powder, Italase (Mild), 1 oz. Ricki's Mozzarella & Ricotta Cheese Making Kit Cut Resistant Glove, Medium Cheese Salt, 8 oz.
I love the quality of this product. Not only do I use them for pressing cheese, but I also use them to weight down cheese while in brine. It doesn't leave any indents or impressions on cheese.


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More than 175 airmen from the 934th Airlift Wing along with four C-130 aircraft are scheduled to return to Minnesota Sunday following a four-month deployment to Southwest Asia. They were responsible for transporting people, cargo and supplies throughout the southwest Asian theatre of operations. Personnel included pilots and co-pilots, navigators, crew chiefs, load masters, logistics […]
A Women's March in Bemidji today as part of a larger movement across the country, organizers say to "support the recognition and improvement of our basic human rights." It coincides with the 100th anniversary of women gaining the right to vote through the 19th Amendment to the U-S Constitution. There's also a panel discussion after […]
Supporters of Senator Amy Klobuchar's bid for president ramp up their efforts in Minnesota on this first day of early voting for the March 3rd "Super Tuesday" presidential primary. Minnesota House Speaker Melissa Hortman and Mayor Jacob Frey are at a morning (8am) event in Minneapolis, while Mayor Melvin Carter shows his support at an […]
Reducing or eliminating Minnesota's estate tax could be back on state lawmakers' radar screen this year, after Senate Democratic Minority Leader Tom Bakk said in Rochester this week that he supports it to keep older Minnesotans from leaving the state. Senate Republican Majority Leader Paul Gazelka's response: "If the governor is also open, so that […]
Two victims and their parents are suing the Bemidji Area School District, alleging administrators did not take adequate steps to protect students from an assistant principal who solicited sexually explicit photos from them. 37-year-old Brandon Bjerknes is serving a 25-year prison sentence. The Star Tribune reports the plaintiffs allege that in 2016 a parent complained […]
The Bemidji Police Department is asking for the public's help in locating a missing woman. 29-year-old Katrina Gulbranson was reported missing by her family on Tuesday and has not been in contact with them since January 8th. Investigators say prior to being reported missing, Gulbranson had been in sporadic contact with detectives and family members […]
Minnesota Attorney General Keith Ellison contends the state's consumer protection laws must be updated in the wake of lawsuit settlements with two major telecommunications providers, Comcast and CenturyLink. Ellison says Minnesotans have lived for 40 to 50 years under the ideology that business is self-regulating, but "it's not. We've got to make sure that there […]
Walz gives thumbs-up to federal court blocking Trump refugee resettlement order
Governor Tim Walz says he welcomes a federal court blocking President Trump's executive order which requires counties to vote on whether they'll accept refugees. "I know that there will be further appeals to that, but at this point in time we're back to something that's worked in this country basically since our beginning," Walz says. […]
Walz rollout of final bonding numbers sets up debate for 2020 session
Governor Tim Walz has released final details of his bonding request for state public works projects, arguing the state is in sound fiscal shape to leverage surplus dollars for much-needed and long-deferred investments. "This is the most local projects that have ever been submitted by a governor's proposal," Walz says. "We need to start tackling […]

redpajama_set_name: RedPajamaCommonCrawl


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Q: How to provide an API to alter CSS / styles / white label for an encapsulated angularJS directive ( re usable widget / component ) In my journey to understand directives and after looking on http://ngmodules.org/ and considering the re usable component / widget model.
A question i have is how would you / whats the best way to provide an API for a hosting application to alter the CSS of an encapsulated widget.
So we have widget A ...
Basic structure
Module
Service
Model
Controller
Directive etc
Any events from the component / widget are emited in order to provide loose coupling
We dont want a dependency on a CSS library like bootstrap so we want to be able to provide an api to allow the hosting application to white label the look and fell to be more in line with itself.
How would you / what is the best way to do this ?

A: I wasn't sure if you're looking to provide default styling within a directive or whether you want the flexibility to apply styling on a directive from a client application.
CSS and styles can be applied on a directive when it is declared.  The CSS/Style rules are "passed" into the directive and depending on how your directive template is defined, will automatically be applied to the underlying template.  If you want more specific control of CSS/styling, you can use the passed in attributes parameter in a compile or link function to indicate where you want the styling to specifically occur.

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You Are the President of Your Own Personal Services Business – Whats your superpower?
This is the message I want to give to my plumber, electrician, painter, and ANYONE who is struggling and thinking that what they do is not important or doesn't pay enough.
Whether you are an electrician, a doctor, a lawyer, a plumber, a consultant or a "grass cutter"- the going rate seems to start at $300 per visit. Think about it. The other day I had a guy come to remove some stuff from around my yard to take to the Dump and he said that it's $350 a load. Someone came to give me a quote for cutting the grass in my yard. He said that it would cost me $400 and an extra $150 to take the cuttings away! In case you are not doing the math – that is $550 per grass cutting session. And I have to cut my grass twice a month in the rainy season. Go figure!
Why then are tradespeople (I hope I am politically correct using this description) ALWAYS complaining about money?
I think it's less about the kind of job and more about the kind of thinking.
Production, quality control, training and development, marketing, finance, and promotion are all in your control.
Seeing yourself as self-employed forces you to recognize that you are also self-responsible and self-determining. That everything that happens to you happens because of your conduct and your behavior. You're in the driver's seat. You're behind the steering wheel of your life. It's up to you to decide how to utilize your talents and abilities in such a way as to bring you the very highest return on the investment of your time and energy.
I recently employed a painter who did a less than stellar job. All he was focused on was drawing down on the agreed project $ figure. He would come, do some painting, then ask for $500. In the end, he seemed upset when we pointed out that an area needed another coat of paint, or where needed to be painted or the fact that we were seeing blue in the white paint and blue on the door knobs. All he could focus on was why wasn't I giving him his money.
I attempted to explain that after giving him the first 50% of the job, that he should only receive the balance when the job was completed to my satisfaction. He kept explaining that he owed money to taxi drivers, that his children needed money for school etc. etc.
I told him that the quality of his work was like his personal signature and reputation. That it spoke volumes about him long after he left.
You are responsible for making a living. People can give you opportunities, advice, or guidance but it's up to you to use and apply it to improve what you do, and how you do it.
You're the boss. No one else can make the critical decisions that will determine your future OR your fortune.
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PHL must shift to renewable energy, says Caritas exec
Jan. 30, 2017 MART D. SAMBALUD
DAVAO CITY, Philippines—The country must shift from coal to renewable energy, an official of the Caritas Philippines said Monday.
Fr. Edwin Gariguez, national secretariat for Social Action and Caritas Philippines executive secretary, issued this statement during the energy forum dubbed as the "Catholics & Coal" conference in Chicago, Illinois.
Hosted by the Center for World Catholicism and Intercultural Theology of De Paul University, the forum draws on Catholic Social Teaching to connect the American Church's experience with the issue to the situation facing the Church in the global South.
"The issue of coal mining and the operation of coal fired power plants all over our country is causing an alarming concern because of their harmful impacts," he pointed out.
He claimed that the extraction and utilization of fossil-fueled energy sources have caused damages to the environment, health, and livelihood of poor communities.
According to Gariguez, the longest-running coal mining project in the country is the coal mining in Semirara Island, Antique. He said the coal mining operation has led "to immeasurable ecological destruction, including the destruction of hectares of mangroves due to clearing operations, land reclamation, dumping of infills, and siltation."
Apart from the ecological destruction, it has also affected the residents relying on fishing and seaweed farming for food security and livelihood as "toxic chemicals build up in surrounding waters, increase of cancerous particulate matter in the water and air….and loss of coral areas owed to dumping of infills and pollution."
Citing a 2015 data from the Department of Energy, Gariguez said the Philippines is "becoming more heavily dependent on coal, contributing 44.5-percent to the power generation mix."
"This is in total contradiction to the global consensus in the Paris climate conference, and an outright inconsistency with the country's commitment in its Intended Nationally Determined Contribution (INDC) to cut 70-percent of its carbon emission by 2030," Gariguez said.
Presently, there are19 existing coal-fired power plants operating across the country. At least 39 more coal-fired power plants are expected to be operational by 2020, he added.
Gariguez, however, said that "even without new dirty and harmful energy projects, the country can still fulfill its energy demands by building alternatives."
As of September 2015, he said a total of 682 renewable energy projects have been approved with a potential generating capacity of 13,574.68 megawatts, while 242 more contracts are still pending for approval. (davaotoday.com)
← Partial distribution of claims for ML victims urged After N. Cotabato clash, NPA doubts if peace panel, Duterte in control of AFP →


Provides expertise in analyzing technical learning needs for a business or function then designs and delivers training solutions. Requires mastery of a body of theoretical knowledge. Requires developed and strong foundation of function skills and knowledge of relevant technologies.


Glossary Credits: WebMD and the Cleveland Clinic Heart Center.
The removal or destruction of tissue.
A document written in "good" health which informs your family and health care providers of your wishes for extended medical treatment in times of emergency.
Exercise which can improve your functional ability and, in some cases, reduce symptoms of heart disease. It is repetitive in nature and involves the large muscle groups. Examples are walking, swimming, and cycling.
Small portable electrocardiograph machines that are able to record the heart's rhythm. Each type of monitor has unique features related to length of recording time and ability to send the recordings over the phone. They include: Holter Monitor, Loop Recorder, and Transtelephonic transmitter.
A condition characterized by a deficiency of red blood cells. Anemia reduces the amount of oxygen available to the body.
A sac formed by the bulging of a blood vessel wall or heart tissue. When aneurysms grow too large, they can rupture and the bleeding can be life threatening. Aneurysms that have grown too large should be removed.
Discomfort or pressure, usually in the chest, caused by a temporarily inadequate blood supply to the heart muscle. Discomfort may also be felt in the neck, jaw or arms.
The spontaneous or drug-induced growth of new blood vessels. The growth of these vessels may help to alleviate coronary artery disease by rerouting blood flow around clogged arteries.
An invasive procedure, during which a specially designed balloon catheter with a small balloon tip is guided to the point of narrowing in the artery. Once in place, the balloon is inflated to compress the fatty matter into the artery wall and stretch the artery open to increase blood flow to the heart.
A group of drugs used to treat high blood pressure and heart failure. ACE inhibitors block a specific enzyme (ACE or angiotensin-converting enzyme) that retains salt in the kidney and can cause heart and blood pressure problems. ACE inhibitors have been shown to decrease the risk of dying from a heart attack.
A group of drugs used to treat high blood pressure.
A ring of tough fibrous tissue that is attached to and supports the leaflets of the heart valve.
The normal anatomy for the coronary arteries involves their origin from the aorta at each of two separate sites. Sometimes people can be born with the origin of a coronary artery that comes from an abnormal site and this can lead to problems of coronary ischemia which can subsequently lead to a heart attack. Not all coronary anomalies need surgery, but some do and the specific operation depends on which of the many varieties of coronary anomalies is present.
A medication used to treat high blood pressure.
Vitamins (A, C and E) that may help to limit the cellular damage caused by free radicals (which are released when tissue is being injured, such as during the progression of heart disease.) Studies suggest that certain antioxidants may protect against coronary artery disease.
Large artery leaving the heart. All blood pumped out of the left ventricle travels through the aorta on its way to other parts of the body.
The aortic valve is the last valve through which the blood passes before it enters the aorta or main blood vessel of the body. The valve's role is to prevent blood from leaking back into the left ventricle from the aorta after it has been ejected from the heart.
When replacement of an aortic valve is necessary it is possible to replace the valve with another human valve known as an aortic valve homograft. This operation involves cardiopulmonary bypass.
The aortic valve is the last valve in the heart through which the blood travels prior to circulating in the body. When this valve is leaking or too tight, a surgeon may be able to repair the valve rather than replace it.
In patients who require coronary artery bypass graft surgery, it is sometimes desirable to use arteries from other parts of the body to provide the bypass grafts. This is known as arterial grafting. The alternative is to use vein grafts for coronary bypass surgery.
This procedure is used to clean out clogged heart arteries. A DCA catheter has a hollow cylinder on the tip with an open window on one side and a balloon on the other. When the catheter is inserted into the narrowed artery, the balloon is inflated, pushing the window against the fatty matter clogging the vessel. A blade (cutter) within the cylinder rotates and shaves off any fat, which protruded into the window. The shavings are caught in a chamber within the catheter and removed. This process is repeated as needed to allow better blood flow.
The process whereby abnormal deposits of lipids, cholesterol and plaque build up, leading to coronary artery disease and other cardiovascular problems.
The upper chambers of the heart. (Atrium refers to one chamber of the heart).
Atrial flutter is a regular heart rhythm in which many impulses begin and spread through the atria. The resulting rhythm is organized, but so rapid that the atria are not able to fully empty their contents into the ventricles.
An abnormal hole located in the walls between the two atria. Tiny defects called patent foramen ovale are present in up to 30% of people and are of no consequence except in unusual circumstances. Moderate size to larger size defects should be corrected and may require heart surgery.
A group of special cells located near the center of the heart that helps to regulate the heart rhythm. Here, the electrical current slows for a moment before going on to the ventricles.
The top chamber of the heart. There are two atria — the left and the right, divided by a muscular wall, called the septum. The atrium contracts before the ventricle to allow optimal filling of the ventricle.
A procedure used to clean out clogged heart arteries. A specially designed balloon catheter with a small balloon tip is guided to the point of narrowing in the artery. Once in place, the balloon is inflated to compress the fatty matter into the artery wall and stretch the artery open to increase blood flow to the heart.
During this surgical procedure, to treat heart failure, the surgeon cuts out a piece of the patient's enlarged left ventricular muscle. The intention is to reduce the size of the left ventricular cavity, improve left ventricular function and reverse congestive heart failure. Long-term results found the procedure unsuccessful, however, the procedure has led to better surgical techniques to treat those with heart failure (see infarct exclusion surgery).
A drug that slows heart rate, lowers blood pressure, controls angina and protects patients with prior heart attacks from future heart attacks.
Removal and analysis of a tissue sample.
The force exerted in the arteries by blood as it circulates. It is divided into systolic (when the heart contracts) and diastolic (when the heart is filling) pressures.
A number that reflects body weight adjusted for height.
Part of the electrical pathway of the heart that delivers electrical impulses to the ventricles of the heart. Normally, electrical impulses start in the sinoatrial or SA node and travel to the atrioventricular or AV node. Then it goes to the bundle of His. The bundle divides or branches into a right bundle and the left bundle. The bundles take the impulse through the ventricles (bottom chambers) to cause them to contract.
Normally, the electrical impulse travels down both the right and left bundle branches at the same speed and the ventricles contract at the same time. If there is a block in one of the branches, it's called a bundle branch block. A bundle branch block causes one ventricle to contract just after the other ventricle.
Tiny blood vessels connecting arteries to veins. These blood vessels carry oxygen and nutrients to individual cells throughout the body.
An organic compound, found in food substances such as sugar, cereal and other grain products, fruits and vegetables, that provides fuel for the body.
A gas created during metabolism, when the cells use oxygen to burn fat and release energy. The lungs release carbon dioxide when you breathe out.
A heart procedure used to diagnose heart disease. During the procedure, a catheter (inserted into an artery in your arm or leg) is guided to your heart, contrast dye is injected, and X-rays of the coronary arteries, heart chambers, and valves are taken.
Doctor specializing in the diagnosis and treatment of heart disease.
An abnormal heart condition in which the heart is dilated (poor pumping power), restrictive (impaired ability of the heart to fill) and hypertrophic (enlarged heart).
A technique designed to temporarily circulate oxygenated blood through the body of a person whose heart has stopped. It involves assessing the airway; if necessary breathing for the person; determining if the person is without a pulse; and if necessary, applying pressure to the chest to circulate blood.
Relates to the heart and blood vessels.
A procedure used to convert an irregular heart rhythm to a normal heart rhythm by applying electric shockor using certain medications.
A slender, hollow, flexible tube.
A very small amount of radiation is used to produce an image of the structures of the chest (heart, lungs and bones) on film.
A fatty substance made by the body and found in some foods. Cholesterol is deposited in the arteries in coronary artery disease.
Thin chords that provide support to the tricuspid and mitral valves of the heart helping them to open and shut properly.
An abnormality where the ends of the fingers and toes enlarge and the nails curve; often it is related to an inadequate oxygen-rich blood supply, however it can be hereditary and completely normal. Often seen with congenital heart defects, but also seen in other conditions.
A severe narrowing of the aorta, causing a decrease in blood flow to the lower part of the body. This narrowing is a congenital defect and can be corrected with surgery.
Small capillary-like branches of an artery that form over time in response to narrowed coronary arteries. The collaterals "bypass" the area of narrowing and help to restore blood flow. However, during times of increased exertion, the collaterals may not be able to supply enough oxygen-rich blood to the heart muscle.
A surgical procedure that helps to repair the damage caused by defective heart valves. In some patients, specifically those with rheumatic heart disease, this area of the heart (also called the commissures) can become scarred and the valve leaflets fail to open and allow blood to flow through easily. In this surgery, the commissures can be released or reopened.
Starchy foods that are good sources of energy and nutrients, such as whole grain breads, rice, and pasta.
Heart defects present at birth.
A condition where the heart muscle weakens and can't pump blood efficiently throughout the body.
The pericardium is the sac around the heart. In people with constrictive pericarditis, this sac becomes inflamed and scarred leading to shrinkage of the pericardium. This can prevent the heart from filling to its full extent.
Network of blood vessels that branch off the aorta to supply the heart muscle with oxygen-rich blood. There are two main coronary arteries: the right and the left. The left splits into two arteries called the circumflex and the left anterior descending (LAD) arteries, thus, the heart is often considered to have three major coronary arteries.
A build-up of fatty material in the wall of the coronary artery that causes narrowing of the artery.
Repeated contractions and dilations of the coronary arteries, causing a lack of blood supply to the heart muscle. It may occur at rest and can even occur in people without significant coronary artery disease.
A blue tint to the skin, indicating the body is not receiving enough oxygen-rich blood.
A machine that is used to administer an electric shock to the heart in order to re-establish normal heart rhythm.
A condition in which the body does not produce or respond to insulin (a hormone produced by your body, which allows blood sugar or glucose into your body's cells for energy).
The pressure of the blood in the arteries when the heart is filling. It is the lower of two blood pressure measurements (for example, 120/80, where 80 is the diastolic pressure).
A disease of the myocardium (heart muscle) that causes the heart cavity to become stretched and enlarged, and the pumping capacity of the heart is reduced.
The increase in size of a blood vessel.
If you are unable to exercise on a treadmill or stationary bicycle for a stress test, a medication, called dipyridamole (Persantine) is used instead of exercise to test the heart's blood flow.
A drug that enables the kidneys to rid the body of excess fluid. May be referred to as a "water pill.".
A procedure that involves infusing a medication (dobutamine) through an intravenous (IV) line while you are closely monitored. This drug stimulates your heart allowing evaluation of heart and valve function at rest and with exertion, when you are unable to exercise on a treadmill or stationary cycle.
Echocardiography is an imaging procedure that creates a graphic outline of the heart's movement, valves and chambers using high-frequency sound waves that come from a hand held wand placed on your chest.
An imaging procedure that creates a moving picture outline of the heart's valves and chambers using high-frequency sound waves that come from a hand held wand placed on your chest or passed down your throat. Echo is often combined with Doppler ultrasound and color Doppler to evaluate blood flow across the heart's valves. Doppler senses the speed of sound and can pick up abnormal leakage or blockage of valves.
In people who are unable to provide oxygen for their own blood or enough blood circulation, they can be put on life support known as extra corporeal membrane oxygenation. The blood is withdrawn from a large vein in the body and passes through a pumping mechanism, and then through a device that puts oxygen into the blood and removes carbon dioxide from the blood. The blood is then returned to the body and circulated in such a way as to sustain life.
Swelling; the accumulation of fluids, usually in the hands, feet, or abdomen.
The amount of blood pumped out of a ventricle during each heartbeat. The ejection fraction evaluates how well the heart is pumping.
The EKG records on graph paper the electrical activity of the heart using small electrode patches attached to the skin.
An EP study is a test that evaluates the electrical activity within your heart. This test is used to help your doctor find out the cause of your rhythm disturbance and the best treatment for you. During the test, your doctor may safely reproduce your abnormal heart rhythm, then give you medications to see which one controls it best.
A blood clot that moves through the blood stream.
An infection of the inner lining of the heart or its valves. It is usually caused by bacteria and is more likely to occur in people who have heart valve defects or have had heart surgery to treat valve disease.
A treatment for those with symptomatic coronary artery disease (also called refractory angina), not eligible for standard treatments of revascularization (such as bypass surgery.) During EECP, cuffs wrapped around the calves, thighs and buttocks are inflated and deflated, gently but firmly compressing the blood vessels in the lower limbs, increasing blood flow to the heart. EECP may stimulate the openings or formation of collateral vessels to create a "natural bypass" around narrowed or blocked arteries.
A small recorder (monitor) is attached to electrodes on your chest. It is worn continuously for a period of time. If symptoms are felt, an event button can be depressed, and the heart's rhythm is recorded and saved in the recorder. The rhythm can be saved and transmitted over the phone line.
A procedure that combines echocardiography with exercise to evaluate the heart's function at rest and with exertion. Echocardiography is an imaging procedure that creates a picture of the heart's movement, valves and chambers using high-frequency sound waves that come from a hand held wand placed on your chest. Echo is often combined with Doppler ultrasound and color Doppler to evaluate blood flow across the heart's valves.
A test used to provide information about how the heart responds to stress. It usually involves walking on a treadmill or pedaling a stationary bike at increasing levels of difficulty, while the electrocardiogram, heart rate and blood pressure are monitored. If you are not able to do activity, medications may be used to "stress" the heart.
An indigestible carbohydrate found in foods such as fruits and vegetables; aids in digestion.
Abnormally rapid, inefficient contractions of the atria or ventricles. Ventricular fibrillation is life-threatening.
One form of rapid heartbeat.
When the surgeon removes the mammary artery from its origin to use as a bypass graft.
A destructive fragment of oxygen produced as a by-product. Increased free radicals are thought to trigger atherosclerosis.
A test used to determine the cause of fainting spells. The test involves being tilted at different angles for a period of time. Heart rhythm, blood pressure, and other measurements are evaluated with changes in position.
A condition where the heart muscle weakens and cannot pump blood efficiently. Fluid accumulates in the lungs, hands, ankles, or other parts of the body.
Heart surgery is any surgery that involves the heart or heart valves.
There are four valves in the heart: the tricuspid and the mitral valve, which lie between the atria and ventricles, and the pulmonic and aortic valves, which lie between the ventricles and the blood vessels leaving the heart. The heart valves help to maintain one-way blood flow through the heart.
A protein in red blood cells that transports oxygen and carbon dioxide and gives blood its red color.
After a heart attack, some areas of heart muscle do not pump as they should. Some areas will have permanent damage. Other areas are able to return to their normal function if blood flow is returned to that area by medications or a procedure. Hibernating myocardium is heart muscle that is "resting" and may possibly return to normal function.
Lipoprotein particle in the blood. HDL is known as "good" cholesterol because it deposits cholesterol in the liver, where it is excreted by the body. High HDL is thought to protect against coronary artery disease.
A small recorder (monitor) is attached to electrodes on your chest. It records the heart's rhythm continuously for 24-hours. After the monitor is removed the heart's beats are counted and analyzed by a technician with the aid of a computer. Your doctor can learn if you are having irregular heartbeats, what kind they are, how long they last, as well as what may cause them.
An amino acid. High levels of homocysteine are a risk factor for coronary artery disease.
A process used to harden unsaturated liquid vegetable oils into saturated fats.
High levels of fat in the blood, such as cholesterol and triglycerides.
An abnormal enlargement of an organ or thickening of its tissue. Ventricular hypertrophy is the name given to a thickened ventricle.


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Norwegian prime minister on Trump's immigration comments
By Christina Capatides, Lauren Meltzer
February 1, 2018 / 4:56 PM / CBS News
Global GoalsCast 1
Global GoalsCast 1 10:55
DAVOS, Switzerland -- Norwegian Prime Minister Erna Solberg and President Trump recently attended the World Economic Forum, which was held in Davos, Switzerland. Solberg spoke with Hub Culture executive editor Edie Lush -- co-host of Global GoalsCast -- about her conversation with Mr. Trump on immigration.
Mr. Trump, during a conversation in the Oval Office, recently said he'd prefer to see immigration from Norway over what he called "sh*thole countries." Solberg responded: "We peaked in immigration to the U.S. in 1886, so there are as many Norwegian Americans as there are Norwegians in Norway. So, I think we have done our deal to the people in the U.S."
"He treated me very nicely, politely, and it was an interesting discussion. Between Norway and the U.S., it's usually about security policies," Solberg said. "We are neighbors to Russia in the north. We have the longest sea line. We are quite a long country, scarcely populated. The control of the North Atlantic at sea is extremely important for the connection in NATO between the American parts of NATO and the whole of Europe."
"But I also hope that we'll see a U.S. that understands security policies about preventing conflict, also about following up on the sustainable development goals in the future, environmental change that has to stop," she continued. "All of these issues are important."
"After he met with you, he indicated in fact that the U.S. could re-enter the Paris Accord," Lush interjected. "What kind of powers of persuasion were you using with him?"
"He said that he felt that the Paris accord was a bad deal for the U.S., but he wasn't against doing something about climate change. So, I'm not sure if I have very good powers of persuasion, but I think I made an argument for it," Solberg said. "There is a lot of technology development now because some of us, like Norway, is doing strict policies on Co2 emissions; meaning that there is business opportunities. Over 40 percent of new car sales in Norway are either hybrid or electrical cars. There are business opportunities in this."
Solberg went on to say that the U.S. remains the "world's most innovative country" that creates the most "new types of technology."
"If you put that to work to the benefit of climates, it will really also create jobs in the U.S.," she said.
Norwegian leader on Trump 03:10
Last year, the United Nations named Norway as the world's happiest country, significantly outranking the U.S.
Solberg credited a "good education system" and "ways of large trust in the institution" for her country's success.
"It's a trust in politicians, it's a trust in government institutions, it's a trust in their legal system, and what I think is important to encourage, which you have to have political parties that are open for change, open to reach out to people," she said. "And also not just election machines, but in fact have real political debates about 'Where do you go from here?' which I hope we have in our society."
"One of our challenges is to make sure that those aspects of our society is kept when we have more migrants who have come, more refugees who have come in the last years, and when they bring their families they should also get into the Norwegian society," Solberg added. "That's one of the biggest things we are working on now. Children of immigrants should have the same possibilities as the children of people born in Norway."
Is it possible to change the world? Can we still make the planet a better place for us all to live? UN special adviser Claudia Romo Edelman and Hub Culture executive editor Edie Lush -- hosts of the Global Goalscast -- believe the answer is a resounding 'yes,' and that everyone can play a part. Subscribe to the podcast here.
First published on February 1, 2018 / 4:56 PM
Christina Capatides
Christina Capatides is the director of social media and trending content for CBS News. She is also a senior producer and reporter, focusing on culture and gender equity.
Davos: The World Economic Forum
Davos: The World Economic Forum More
Global leaders call for more female participation at World Economic Forum
Women do more grunt work at home, no matter their pay or education
Planned Parenthood leader speaks out on Roe v. Wade anniversary
Trump touts "thriving" U.S., rejects "prophets of doom" in Davos
Greta Thunberg calls for end to all fossil fuel investment "now"
Latest From "60 Minutes"
How Washington is bolstering security for the inauguration; Then, former Capitol Police Chief Steven Sund's account of the Capitol assault; And, Washington Football Team QB Alex Smith's comeback from nearly losing his leg.
Bill Whitaker speaks with one of the three law enforcement officials who resigned in the wake of the attack on the Capitol, and reports on the threat behind what one expert says "may have been the most predictable terrorist incident in modern American history."
NFL QB Alex Smith's comeback from nearly losing his leg
Washington Football Team Quarterback Alex Smith was fighting for his leg and his life in November 2018 after he suffered a gruesome on field injury. Following thousands of hours of rehab and help from the US Military, he defied expectations to make a return to the NFL, in one of the greatest sports comebacks ever.
President-elect Joe Biden will be inaugurated in the same spot where insurrectionists waged an assault on the U.S. Capitol just weeks before. Scott Pelley reports on how officials are ensuring the inauguration will be safe.
Right Rail - Video Promo - Listing
Kamala Harris on the job ahead
In part one of our two-part interview with the Vice President-Elect, Kamala Harris talks with "Sunday Morning" host Jane Pauley about her role in this unique moment in history. The former prosecutor, attorney general and U.S. Senator also looks back at the many "firsts" of her career; her debates with her mother about optimism vs. realism; and the January 6th assault on our democracy on Capitol Hill.
A protected right? Free speech and social media
A decade ago social media was hailed as an organizing tool for pro-democracy rallies, giving voice to the voiceless. But it has also become a forum for conspiracy theories, disinformation and hate speech. President Donald Trump was recently banned from Twitter following his incitement of rioters, and his social media accounts on Facebook and Instagram were suspended. Correspondent Lee Cowan looks into the legality and implications of tech companies "de-platforming" a user – even a president.
After 20 years of trying, standup comedian Sarah Cooper became an overnight success when she started lip-syncing President Trump, stripping away his image and using only his words, in social media posts that became comedy sensations. Correspondent Jim Axelrod talks with Cooper about her rise to fame, and what the future may hold for her, now that her object of mockery is leaving the stage.
Passing the torch: An inauguration amidst crisis
An inauguration represents a grand re-opening of the American experiment. But as Joe Biden is sworn in as our 46th President, old grudges imperil the traditions of renewal. "60 Minutes" correspondent John Dickerson talks with New Yorker writer Jill Lepore, New York Times columnist Jamelle Bouie, and Washington Post columnist Michael Gerson about the challenges facing a president taking charge of a nation enflamed by mistrust, disinformation and insurrection.
An unprecedented impeachment
President Donald Trump became the first chief executive to be impeached twice, when the House of Representatives voted this past week that he had incited a violent insurrection upon the U.S. Capitol. Correspondent Rita Braver talks with GOP Rep. Jaime Herrera Beutler, who joined with nine other Republicans to vote for impeachment.
Latest From CBS News
Director-General Tedros Adhanom Ghebreyesus said that most vaccine makers have targeted locations where "profits are highest."
One human rights group says the Netanyahu government's approval of East Jerusalem construction puts it on a "collision course" with the Biden White House.
"Insurrectionists planning attacks across the country this week and Florida is jailing scientists for the crimes of knowing and speaking," she tweeted.
President-Elect Joe Biden's proposed $1.9 trillion relief bill could face some hurdles, analysts say.
Watch: Player surprised with scholarship while working at Walmart
Dee Mitchell was surprised by his head coach — in the middle of Mitchell's 1-10 p.m. shift at Walmart as a produce stocker.
Right Rail - Gallery Promo
A look back at the esteemed personalities who've left us this year, who'd touched us with their innovation, creativity and humanity
Dec 17, 2020 150 photos
Shows and movies you'll want to stream soon.
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Joe Biden through the years
Newly elected to be the 46th president, Biden has had a long political career and a personal life filled with triumph and heartbreak.
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Astrophotography: Stunning images of Idaho's night sky
The Central Idaho Dark Sky Reserve, draped over nearly one million acres of wilderness areas and the Sawtooth National Forest, is a major draw for amateur astrophotographers capturing the heavens
Sep 13, 2020 31 photos
The most popular dog breeds in America
The American Kennel Club has released its latest list of the nation's most beloved breeds.
Oct 28, 2020 101 photos
The girl recorded a message to send to friends and family via a Ring doorbell.
She said she is also working on getting her 1971 show "The Pet Set" rereleased.
Ric Jackson has fixed more than 650 bikes for friends, neighbors, even strangers.
Agnes Keleti recently celebrated her 100th birthday, and her 10 Olympic medals are just a part of her incredible life story.
The Paul O'Sullivan Band recorded its first album during lockdown — giving members an outlet during a difficult year.
One pregnant woman's battle with COVID-19 sparked a valuable friendship.


As temperatures drop and the light wanes beyond your door, set the mood for wintry festivities at home with this elegantly rustic runner that features a traditional fir cone lace motif flanked by a fir-and-diamond lace pattern and a simple, textured seed stitch border. The finished size is approximately 10" wide and 40" long, but this is also a fabulous one-skein project that can be adjusted depending on the amount of yardage available. The runner is worked in two pieces and grafted in the center.


Breath of Earth by Beth Cato Review - Unabashedly Fantastic!
I am not always as fond of Steampunk as a genre. The authors tend to focus on "cool alternate toys I can imagine" and forget about story. Imaginary technology bores me without an amazing plot and characters I can identify with and cheer for.
Breath of Earth has complex characters and plot in abundance. I don't know which I liked better – the wonderfully diverse and rich characters or the non-stop excitement of the story.
The setting is alternate history San Francisco on the eave of the 1906 great earthquake. But this is an America which is ruled by Japanese and Americans and where the magic of geomancers keeps stability in the world. The instability of world affairs, including brutal wars in India and China, sets the stage for the complicated interweaving of the plot.
Ingrid Carmichael, our delightful main character, is a strong woman of magic in a patriarchal society that doesn't believe women can be geomancers. Her mentor and second father Mr. Sakaguchi helps her hide her powers. But her world literally explodes around her when someone targets the of Earth Warden's Auxiliary. She saves Mr. Sakaguchi, but he is wounded as they are targeted by assassins. With the help of handsome airship pilot Cypress Jennings (romance – yeah!) and his mechanic Fenris, Ingrid must save her mentor, find out who is targeting geomancers and try to prevent the world from literally shaking apart at the seams. The story's non-stop action turns even more frantic when Ingrid realizes that instead of the solution, she may just be the problem.
And that is a very quick and dirty summary which leaves out most of the plot-lines and twists. Between the lively characters, the unabashed use of magic and interwoven plot this was a stay-up-past-your-bedtime read. An instant favorite on my bookshelf, I will happily reread Breath of Earth many times.
Beth Cato is the author of the Clockwork Dagger series from Harper Voyager. She's a Hanford, California native transplanted to the Arizona desert, where she lives with her husband, son, and requisite cat. Follow her at BethCato.com and on Twitter at @BethCato.
Very excited to say that Beth Cato sent me an excerpt! This excerpt from chapter 1 offers an introduction to geomancy.
Whimpers and moans welcomed Ingrid to the junior classroom. Nearest to the door, a dozen boys half sprawled over their desks. A blue mist overlay their skin, and beneath that mist were the sure signs of power sickness—skin flushed by high fever, thick sweat, dull eyes. The rest of the class stared, their expressions ranging from curiosity to horror. Some of them still showed signs of very recent recovery in their bloodshot eyes. None of these boys was older than ten; the youngest was a pudgy-faced eight.
fault he'd been so inept with his accounting. Biting her lip, she held out the bag. He snatched it from her fingertips.
three days before. These students had been directly exposed to the current and hadn't been allowed access to any kermanite. As a result, they spent the past few days bed-bound in misery as though gripped by influenza.
Thank God none of them were as sensitive as Ingrid. Another direct tremor would cause their temperatures to spike even more, and could even lead to death.
The teacher adept pressed a piece of kermanite to a boy's skin. He gasped at the contact. Blue mist eddied over his body, the color evaporating as it was pulled inside the rock.
If she could see the kermanite in the adept's hand, the clear crystal would be filling with a permanent smoky swirl. It took a trained mechanic to rig an electrical current to tap the trapped magic as a battery. When the energy within was exhausted, a crystal turned dull and dark. Once that happened, kermanite became a useless rock.
voice still ragged. It would take him hours to fully recover.
Ingrid looked away, that familiar anger heavy in her chest.
stones could be easily switched out once they were full.
She had to be far more subtle. Her kermanite chunks clinked together in her dress pocket. She had to take care not to touch them today, or the energy she held would be siphoned away.
everyone else had the capacity of a private safe.
When it came to her natural skill, Ingrid often regarded herself as a rare fantastic or yokai — not like garden ornamentals like the kappas or naiads sold to the stuffed shirts on Market Street — but like the geomantic Hidden Ones Mr. Sakaguchi so loved to research. She was a creature relegated to idle fancy and obscure mythology, and aggravating shoes.


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Investment News / Fri 26 Oct 2018
Hackajob gets £5m to help companies hire tech talent
Recruitment tech startup hackajob has raised £5m ($6.7m) to continue its international expansion.
The startup, based in London, raised from an investor pool led by AXA Venture Partuners, existing backer Downing Ventures and Angel investor Dragos Nicolaescu.
Today's news comes after the business closed a £400,000 Seed in May 2016 and amid plans to open a new office in the US next year.
According to the company, the funding will also be used to continue building proprietary technology and to expand the client and candidate relations teams. Funds will also go towards marketing expenditure.
CEO and co-founder of hackajob, Razvan Creanga, spoke about the news: "We are thrilled to be able to continue our mission of making the hiring process unbiased, fairer and meritocratic on a global scale. Our constant focus on innovation and deep understanding of technical talent, alongside our in-house expertise, has allowed us to develop a unique business and we're very excited to take it to the next level."
Set up in 2014, hackajob was launched in a bid to improve the traditional recruitment agency approach and make it easier for companies to hire technical talent.
COO and co-founder Mark Chaffey went on to note: "After seeing the impact our unique approach to tech recruitment has had on our client base; by helping them improve their quality of hire whilst saving huge amounts vs traditional channels, we're incredibly excited about scaling hackajob globally to help more companies hire the right tech talent for their business."
Hackajob automatically matches clients with highly curated candidates from their talent pool of more than 60,000 technical people and can view their code or cloud infrastructure implementation alongside their profile.
Companies are then able to manage interviews, integrate with existing ATS's and ask candidates to complete specific challenges unique for their company.
Imran Akram of AXA Venture Partners, who will be joining the board, said: "hackajob have transformed recruiting with data, evidenced by the proportion of recommended candidates who are hired and we are excited to be helping them expand internationally."
Investment Director at Downing Ventures, Richard Lewis, concluded: "We are delighted to continue supporting this fantastic team, who have come a long way since 2015, and thrilled to work with AXA Venture Partners throughout this next phase of global growth."
Downing VenturesInvestmentsLondonrecruitment tech
Need to Know / 22 hours ago
Chip designer Alphawave gets 225% sales boost following IPO woes


The 2018 British GT Championship season will kick-off on Easter weekend at Oulton Park International circuit. The 35 crew are ready for two one-hour races on the 4.3 km (2.69-mile) circuit in Cheshire. Thirteen crews are entering the competition in GT3 class and twenty-two crews will race in GT4 class.
Same as in 2017, this season will feature seven racing weekends with ten races. The double-header events are planned for Oulton Park, Snetterton and Spa-Francorchamps. The season's finale will take place at Donington Park on September 22-23.
Team Parker Racing's Rick Parfitt Jr. will defend his championship title in the #1 Bentley Continental GT3. Seb Morris, his partner from the last year's victorious campaign, moved to the Blancpain GT Series and will be replaced by Ryan Ratcliffe in the #1 car. Parfitt and Ratcliffe have a successful history together, they won GT4 class title in 2013 British GT Championship.
Last year's vice-champions Phil Keen and Jon Minshaw will stay together in the #33 Barwell Motorsport Lamborghini Huracan GT3. Jonny Adam and Derek Johnston, champions in 2016 and last year's third-placed crew, will be separated this year in two different Aston Martins. Jonny Adam will share the #75 Optimum Motorsport car with Flick Haigh while Derek Johnston will share the #17 TF Sport entry with Marco Sorensen.
One more Danish ace joined TF Sport – Nicki Thiim will share the #11 car with Mark Farmer. Maxime Martin, new Aston Martin Racing's driver in the FIA WEC, will also race in the British GT in the #47 Jetstream Motorsport's car. Aston Martin's veteran Darren Turner, who was successful in international competitions, will make his debut in British GT Championship alongside Andrew Howard.
In the GT4 class, HHC Motorsport will try to defend a title with #55 Ginetta G55. A new pair of drivers in that car would be Ginetta GT4 Supercup champion Callum Pointon and his partner from Denmark Patrik Matthiesen.
The biggest novelty in GT4 class is a bespoke Jaguar F-Type SVR. Invictus Games Racing will run two unique cars, also playing an active role in the rehabilitation of wounded, injured and sick veterans of the British Armed Forces. Team's Pro drivers Matthew George and Jason Wolfe would be joined by Major Steve McCulley and RAF Sergeant Ben Norfolk.


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Figures and Statues
1:18 Scale Classic TV Series Batmobile With Batman & Robin - Hot Wheels
The story goes that he was approached by producers from Fox who were going to be doing a BATMAN TV Series and needed an exotic car. George sketched out a version of the Futura with suitable Bat alterations and presented it to the producers. George felt it was the perfect answer.Sometime later in October of 1965, the BATMOBILE was born. Show more Show less


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Four Higher Things youth conferences planned
Reporter Staff
Registration is open for four Higher Things Lutheran youth conferences set for this summer.
Sharing the theme "Sanctified," the conferences will be held:
July 3–6 at Carleton College, Northfield, Minn.;
July 10–13 at Southern Illinois University, Carbondale, Ill.;
July 24–27 at the University of Kansas, Lawrence; and
July 31–Aug. 3 at Pacific Lutheran University, Tacoma, Wash.
All of the conferences — planned for junior-high and high-school-age youth — will run Tuesday through Friday, with scheduled times for worship, learning and organized free-time activities. All will be "deaf-friendly," with sign-language interpreters.
the Rev. George Borghardt, president of Higher Things and pastor of Immanuel Lutheran Church, Bossier City, La., and the Rev. Donavon Riley, pastor of Saint John Lutheran Church, Webster, Minn. (Minnesota conference);
the Rev. Chris Hull, pastor of Zion Lutheran Church, Tomball, Texas, and the Rev. Brent Kuhlman, pastor of Trinity Lutheran Church, Murdock, Neb. (Illinois);
the Rev. Aaron Fenker, pastor of Bethlehem and Immanuel Lutheran Churches, Breman, Kan., and the Rev. Bryan Wolfmueller, pastor of Hope Lutheran Church, Aurora, Colo. (Kansas); and
the Rev. Duane Bamsch, pastor of Zion Lutheran Church, Terra Bella, Calif., and the Rev. Todd Peperkorn, pastor of Holy Cross Lutheran Church, Rocklin, Calif. (Washington).
The all-inclusive registration fee of $385 includes three nights of on-campus housing, nine meals and all programming. Rates increase to $410 per person May 1.
"Over the past 17 years, Higher Things conference themes have covered each section of the Catechism except the Ten Commandments," noted Conference Executive Sandra Ostapowich. "The 'Sanctified' conferences will focus on the Ten Commandments and how God has called us to be His own people in Christ."
More than 1,000 worshipers attend the opening Divine Service in the Valparaiso University chapel during one of the Higher Things youth conferences in 2017. This year's conferences are planned for Northfield, Minn.; Carbondale, Ill.; Lawrence, Kan.; and Tacoma, Wash. (Higher Things/Ann Osburn)
The conference hymn, "In the Shattered Bliss of Eden" (LSB 572), was sung by participants at one of last year's conferences.
Higher Things is an LCMS Recognized Service Organization that sponsors annual youth conferences and assists parents, pastors and congregations in cultivating a distinctly Lutheran identity among their youth and young adults. For more information, visit higherthings.org.
Tags higher things Recognized Service Organizations (RSOs) youth
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Broad River's outdoor category grows double digits
by Home News Now September 6, 2022 September 6, 2022
What a difference a year can make in outdoor retail.
A 19 percentage point difference, as it turns out.
A year ago, Broad River Retail, Ashley Furniture's largest licensee in the U.S., was reporting that outdoor sales had increased by 70% year over year, following an outdoor showcase that took place three years earlier.
At that event in 2017, the retailer both introduced its new outdoor category and demonstrated to its partners that it was fully committed to taking it outside.
And it has. That 70% has increased to an 89% rise year over year, which Broad River COO Manny Rodrigues attributes to a concentration on quality in the goods, as well as a continuing trend of Americans seeing patios and decks as an extension of the interiors of their homes.
The Silo Point collection is positioned at the front of the new Broad River Ashley store in Southern Pines, North Carolina. For more images from the store, see below.
"We have really seen growth in this category and we're still bullish on it," Rodrigues says. "We love it for a lot of reasons."
Lynn Knowles, who works on the merchandising team, says that product mix and placement, tied to the seasons, works well in the category. In spring, Broad River places outdoor, especially dining, in the front room of the store, making it top of mind for the retail performance team. In the fall, outdoor is moved back into the store, and the pieces are more about seating and fire pits.
"It really makes it like an oasis in the store and that has contributed greatly to our success," Knowles says.
As with real estate, outdoor retail is about location. Rodrigues says that Broad River's location in the Carolinas and Georgia have had a boom in residential construction and with it, more emphasis on outdoor living. At the same time, people who worked at home because of Covid have a new appreciation for all the rooms of their home – both inside and out.
"The home outdoor experience today is one that just continues to drive a lot of excitement in our stores," Rodrigues says. "Folks are working more and more outside in their outdoor spaces, using outdoor furniture in ways that they wouldn't before. It has become more important to the overall home than it has been in the past."
Knowles says the new definition of home has had a good effect on outdoor retail.
"People are feeling better about making investments in their outdoor spaces," Knowles explains. "They want high-quality furniture on the outside, like they have on the inside."
Rodrigues says that Broad River isn't immune to industry challenges. But the biggest challenge, supply chain shortages, hasn't had as much of an effect, because Ashley has worked hard to keep product in stock and stores supplied.
Another challenge has been a good one to have — because so many offerings have been added to outdoor collections, Broad River has begun displaying them both vertically in the stores and featuring them on kiosks and on iPads and tablets that sales consultants carry with them.
"We have a multiple ways to show the product," Rodrigues explains. "We've put more of it on our website and we are seeing more traffic. Our guests are looking online and then coming to the store and asking to see the Beechcroft sectional or the Clairview dining set."
In addition, product reps coach the 300 employees on the features and benefits of the outdoor furnishings, coupled with an internal LMS system called Ashley Discovery that has videos and other resources the sales team can use.
What, overall, are customers looking for?
Knowles says that generally, guests are looking for designs out of nature and not as much the traditional looks, while Rodrigues said he has seen some pieces scaling smaller to better fit apartments and condominiums.
"That is the genius of the Ashley model, depending on which stage of life you are in, whether you are just out of college and in your first apartment and you need something small, or you are in your small first home and you have more space, as we've got those, too," Rodrigues says.
The Cloverbrooke collection is part of the outdoor display at Broad River's Southern Pines store that Home News Now visited in July.
That model is working, as sales figures show. Rodrigues said that in 2021, the Broad River Retail stores had 98 Million Dollar Memory Makers — sales staff that had each sold $1 million or more in sales, including both indoor and outdoor furniture. That's up almost double from the 51 honorees in 2020.
"We have a gala and each is given time to talk through their story, how they have gotten into this moment," Rodrigues says. "It's grit, determination and perseverance. They have a willingness to be coachable and improve on their craft, to know our product offerings."
In all of it, outdoor is at Broad River Retail to stay.
"We're 100% committed to outdoor," Rodrigues says. "Ashley is committed to it. The product continues to get better and evolve year over year. It goes back to what customers want. What they are telling us and what we are seeing is that outdoor space is being used more and more and it is more and more important to them in their lives to be outside, to enjoy time with family, to enjoy time with friends and they want to have great outdoor furniture. It reflects their personality and their lifestyle."
This small-scale sectional and companion cocktail table is part of Ashley's Cherry Point collection.
The Visola outdoor colldction features a sofa, loveseat and chair plus a cocktail table.
Also on display in the Southern Pines store is the Clare View collection, which includes a sofa, loveseat, chair and occasional table set featuring a cocktail and end tables.
This six-piece curved sectional is part of the Harbour Court collection. It includes a center console that can hold drinks.
Ashley's Grasson Lane collection is shown with seating featuring Navy Blue fabric. It includes a sofa, loveseat, lounge chair and occasional tables.
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Q: iPhone - change the wallpaper?
Possible Duplicate:
change wallpaper via iphone app

How can I change the wallpaper on iPhone using Cocoa Touch/Objective-C ?

A: You can't. Apple doesn't provide any public API. You can find answers to this question in other posts like mentioned in the above comment.
change wallpaper via iphone app
How to change the system wallpaper/background of an iOS device with Objective C?
Setting The Wallpaper On An IPad
How to change wallpaper in iPad programmatically?


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London Bridge terror attack: Seven murdered as terrorists wearing hoax bomb vests run people over before launching stabbing frenzy
Three suspects shot dead by armed officers within eight minutes of police receiving first call
Phil NorrisBreaking News Editor
07:10, 4 JUN 2017
Updated 11:20, 4 JUN 2017
Seven people are now known to have died after a terror attack in London last night.
After running people over on London Bridge in a white van, terrorists left the vehicle and stabbed a number of people.
It was just eight minutes from the first call to police, to the suspects being killed by armed officers.
UPDATES: Seven killed and dozens injured in London Bridge terror attack
At the height of the terror, people in three areas of the capital were told to run and hide by Metropolitan Police.
Dozens were also injured and are being treated at six hospitals in the city after the incidents in the London Bridge and Borough Market areas of south London.
A few hours ago, the Met released a statement saying the attacks were being treated as a terrorist incident and a full investigation is under way.
It said:
At 22:08hrs yesterday evening we began to receive reports that a vehicle had struck pedestrians on London Bridge.
The vehicle continued to drive from London Bridge to Borough Market.
The suspects then left the vehicle and a number of people were stabbed, including an on-duty British Transport Police officer who was responding to the incident at London Bridge. He received serious but not life-threatening injuries. His family has been informed.
Armed officers responded very quickly and bravely, confronting three male suspects who were shot and killed in Borough Market.
The suspects had been confronted and shot by the police within eight minutes of the first call. The suspects were wearing what looked like explosive vests but these were later established to be hoaxes.
The ongoing operation is led by the Met, working closely with British Transport Police, City of London Police, the London Ambulance Service and the London Fire Brigade.
Assistant Commissioner Mark Rowley said: "At this stage, we believe that six people have died in addition to the three attackers shot dead by police.
"I'd like to repeat our request for the public to avoid the following areas: London Bridge and Borough Market. This is to allow emergency services to deal with this incident.
"The investigation is being led by the Counter Terrorism Command and we would ask anybody who has images or film of the incident to pass those to police by uploading it at www.ukpoliceimageappeal.co.uk.
"Our thoughts are with all those involved and those responding to both incidents. Those who are concerned about a loved one can contact the Casualty Bureau on 0800 0961 233.
"We are reviewing and planning to strengthen our policing stance across London over the forthcoming days, and there will be additional police and officers deployed across the Capital.
"I would like to ask the public to remain vigilant and let us know if they see anything suspicious that causes them concern and dial 999 immediately."
It was later confirmed that seven people have been killed.
The London Ambulance Service later reported that around 48 people were injured during the incidents.
The Mayor of London Sadiq Khan said: "We don't yet know the full details, but this was a deliberate and cowardly attack on innocent Londoners and visitors to our city enjoying their Saturday night. I condemn it in the strongest possible terms. There is no justification whatsoever for such barbaric acts."
StroudTeenager, 16, airlifted off holiday island for life-saving brain surgery as he battles mystery illness Jack Deane from Stroud was in intensive care


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Франкова дилатација једна је од најпознатијих нехируршких техника у креирању роднице или неовагине код атрезије роднице. Добра страна ове методе је избегавање хируршке интервенције.  Мана ове технике је временски период у којем ће се креирати неовагина, као и потреба за сталним дилатацијама роднице, што понекад код саме пацијенткиње може довести до одустајања.

Историја
Милерова атрезија  је други најчешћи узрок примарне аменореје. Погађа 1/5.000 до 1/10.000 живорођених жена. Пошавши од ових података Р. Т. Франк је осмислио нехируршку методу за обликовање неовагине  код многих пацијената са вагиналном атрезијом.  Креирање вагине нехируршким путем  др Франк је као посебну технику популаризивао почев од 1938. године, од када се  она  доста успешно изводи.

На основу задовољавајућих клиничких исхода и ниског морбидитета, неколико аутора сугерисало је да се нехируршка вагинална дилатација треба сматрати терапијом прве линије код пацијената са вагиналном атрезијом. То је недавно потврдила група пацијената са милеровском атрезијом, њих 87-91% који су успели да створе функционалну родницу користећи вагиналну дилатацију.

Опште информације
Процедура се изводила тако што се постепеним свакодневним дилатацијама кожни остатак закржљале роднице тегли пут унутра, а потом, након постигнуте дубине роднице, изводи се дилатација ширим дилататорима, да би се добила адекватна ширина вагине, како би био могућ што успешнији сексуални односа.

Франкова почетна техника користила је ручне вагиналне дилататоре у положају литотомиј (сличан лежећем положају тела када је пацијент окренут према горе, са рукама у страну,  ногама које су раздвојене, подигнуте и ослоњене у држач за ноге у стилу чизме или у положају узенгија). Ова техника имала је ограничења као што су замор пацијентових руку и ногу, дужина времена проведеног током процеса дилатације и неудобно позиционирање.

Инграмов метод донекле је превазишао ове потешкоће коришћењем седећег положаја како би се искористила телесна тежина пацијента. Ова метода користи вагиналне дилататоре постављене на специјално дизајнирану столицу у облику бициклистичког седишта које обезбеђује перинеални притисак преко уског и повишеног предњег дела бициклистичког седишта.

Упркос повољном клиничком исходу ове методе, постоје неке практичне потешкоће у изради и руковању бициклистичким седиштем посебно код њене примене у амбулантним условима.

Један чланак извештава о случају у којем је вагинална атрезија успешно лечена коришћењем поједностављене верзије Инграмове методе. У овој модификацији, вагинални дилататори су постављени на обичну амбулантну столицу уместо на столицу са бициклистичким седиштем.

Види још
 Операција промене пола
 Вагинопластика

Извори

Спољашње везе

Креирање вагине нехируршким путем

redpajama_set_name: RedPajamaWikipedia


Stephen King is one of the most fascinating authors around, notably for the unreal number of adaptations of his works. But did you know he self-banned one particular work after its connection to multiple school shootings was revealed?
In 1977 King, writing under the pseudonym Richard Bachman, published Rage, a story about a troubled high school student involved in a school shooting. 11 years later, a copy of that title was found in the personal belongings of Jeffrey Lyne Cox, a high school student who held one class hostage at gunpoint after allegedly being inspired by King's story.
Rage would go on to reportedly inspire a number of similar school shootings between 1988 and 1998, so many in fact that the sheer number convinced King to pull the plug. In 1998, shortly after another shooting connected to Rage, King reportedly approached his publishers and asked them to stop publishing the book and allow it to fall out of print. They agreed.
Today, a small number of copies exist, but they don't come cheap.
On Amazon, copies of Rage are sold by third-party sellers charging anywhere between $500 and $750 for a mass-market used paperback. Yep, you read that right. If you wish to be fancy and buy a standard paperback, a copy will cost you upwards of $1000.
While the staggering price might seem unreasonable or make you ask yourself why anyone would be willing to pay so much for a book, it makes sense when you consider supply and demand. Let's be honest, I'm sure there are King fanatics out there who would definitely pay that much in order to complete their collection of King works.
As for Stephen King, while he may not be profiting from the sales of Rage any longer, his decision to pull the plug appeared to be an easy one.
Feature image via The Geeked Gods.


This year the Jambo seemed to be comfortable in it's own clothes. It liked the way it looked in the mirror and did not care about what anyone thought. As far as events go on the 4&Rotary show calendar, the V 4&Rotary Jamboree is our favourite. The South Island Champs and the Nationals are show and drags, but the 'Jambo' has show, drifting and circuit racing. Three aspects of the car world that the team really likes.
For the 2015 instalment, almost everyone understood the modified import show scene is in a rebuilding phase. Well it has been for a while but give it a few years and we will see enough players emerge again, all of them wanting to be the boss. So everyone was sweet with the show hall being filled with mint streeters rather than dedicated show cars. Trust me with the amount of crazy rides in the build around the country, it will only be a matter of time before they start getting completed and start filling the halls again. But its like the expectation wasn't there so everyone seemed to be having a much better time, rather than being in a competitive environment.
An ex world time attack car There was even a non-mini truck..
You see lots of variety in the schedule of the event itself; If you get sick of looking at all the vehicles in the show hall, you could rock out to the skid pad and see some rides killing all the tyres. If that wasn't your jam, then you could take a walk to the track and go see some cars battling against the clock, or even a bunch of sliders take on the famed Manfield drift section. It's this variety that keeps you entertained and before you know it half the day is gone.
We feel that at Nationals it is always quite difficult to start up a random conversation with strangers, in the South Island champs it's a little easier. At Jambo people are more than happy to strike up a conversation and talk some cars. Tell us about their own ride or just about how the weekend was going. There was a sense of comradery in the Jambo show hall. This may have come down to the amount of club stands in the hall, which are all based around unity. Or it could've been that most the people knew or knew of each other as the lower north modified car community is much smaller in scale than the upper north. Either way it was just a good times, a chilled out atmosphere that keeps us coming back each year.
We hope that you are having a brilliant day, and this letter finds you well.
We are writing behalf of all the lower North Island modified vehicle enthusiasts.
Firstly we would like to say that we really love your events, and thank you for holding them for us to enjoy. We did have one suggestion though for next years event. The Manfield circuit, pit area and the show hall proximity, lends itself to the format that they use for the Chrome Expression Sessions.
The lower North Island is all about building useable tidy street rides, with a splattering of drift hacks. If you changed to this format, it would set the Jambo off into the stratosphere. The thought of ripping round the track with your mates in the car with all your crews rides in-front and behind you, it would almost be like a throw back to the old Manfield open days (for those of your crew that attended 'back in the day' will understand that reference).
Your events are well organised and last years Chrome Expression Sessions was hands down the best car event of the year. So if you guys could please incorporate that same format at Jamboree, that will really set things off for all of us in the lower North.
Thank you so much for your time and we look forward to hearing from you soon.
The Speedmagnet team and the lower North Island modified car community.
Here is part one of the two part photo-set, the drift and track pics will follow soon. Feel free to right click save the pics and upload them to Facebook or keep for your own pleasure. Please all we ask is that the watermarks remain on the photos. To all the people that entered the event, thank you for stepping up and putting your ride on the line for public scrutiny. For those that attended the event, thank you for being part of the event. We Look forward to seeing you next year for a yarn and to talk some cars.


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Q: Disable "Optimize Storage" on Catalina I remember in older versions of MacOS there was a setting in:
System Preferences -> iCloud -> Options @ iCloud Drive -> Optimize Mac Storage

It's been known to cause all sorts of problems, so I want to make sure I disable it, but it is not there any more!
How can I make sure I disable this setting and NOT have Catalina manage free space on my drive for me?

A: Here is how you can ensure iCloud does not take an optimize pass after it downloads the full version of cloud synced app data and finished processing and uploading any selected folders or selected Application data that only exists on your local Mac.

*

*https://support.apple.com/guide/system-information/optimize-storage-space-sysp4ee93ca4/mac
In system preferences, at the very top, select AppleID and in the main pane, you can choose to opt in or opt out of syncing specific buckets of files. The equivalent check box is located at the bottom of that list -  Optimize Mac Storage.


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