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Bird Box (2018)
As a film critic, I feel compelled to write about Bird Box because, apparently, one third of the entire Internet is currently talking about this Netflix sci-fi horror movie. It's about killer monsters that cause people to violently kill themselves upon sight. Netflix has reported that over 40 million customers have watched Bird Box in its first week of its streaming release, which basically means 35 million people likely fell asleep to Netflix and it started playing the new high-profile movie on auto play. I know people that love this movie. I know people that hate this movie. I know people who hate this movie with a passion and go into apoplexy trying to describe their disgust. Bird Box isn't a movie worth strong feelings, both good and bad. It's a fittingly entertaining movie with too many structural flaws, underdeveloped ideas, and diminished tension and stakes.
Malorie (Sandra Bullock) is trying to navigate the post-apocalyptic world of monsters. She's traveling down river with her two children, all blindfolded. Meanwhile, she flashes back to the first few days of the monster outbreak when she found security in a stranger's home until things went from bad to worse to murderous.
Part of the problem with Bird Box is that the monsters never feel that threatening because the hazy rules manage to defang them. Given the unknowable nature of monsters, I'm not expecting a textbook but some level of consistency that won't rip me out of the film. The monsters are only a threat when you look at them, which is fine, except they cannot or choose to refrain from physically interacting with their human targets. I don't know if this is a natural limitation, a choice, or simply anecdotal evidence that will be disproved. Just because the monsters haven't done something yet doesn't mean they might not be able to. Just because the monsters don't attack anyone wearing a blue sweatshirt with a googly-eyed reindeer doesn't mean this is standard. We see at one point the collateral movement of a monster chasing after Sandy and the kids, shoving trees and other forest vegetation aside. They do physically interact with the world; they just do not interact with our characters. This takes away much of the danger of these creatures. There's one scene where a character is struggling to get indoors and, oh no, the garage door is opening. Look out; all he has to do is… continue not looking at the monsters as he was doing without effort. It makes me think of The Simpsons Halloween episode where the key to defeating killer mutant advertisements was not to look (it had Paul Anka's guarantee).
The monsters also adopt the voices of loved ones, so survivors would start to learn from these experiences and begin to carry a deep skepticism about suddenly prevalent loved ones begging for blindfolds to be removed. Does this mean the monsters can psychically read the thoughts of human beings to know what voices to tap into? It made me think of The Bye Bye Man and its Bye Bye Man-induced hallucinations ("Is this cop's face really oozing black blood through empty eye sockets, or is that you Bye Bye Man, you scamp?"). This is an interesting aspect that never feels fully developed, the mistrusting nature of the calls for help. Instead of adopting the voice of dead loved ones, I wish the monsters had chosen more judiciously. You could feature a sequence with someone genuinely calling for help and being left behind by Sandy because, in their blindfolded state, they cannot tell the difference in the authenticity of the speaker's claims.
But what I kept coming back to is why can't the monsters go indoors? This was a hurdle I could never fully get over because it cheapened the threat for me. As with any apocalyptic or viral outbreak, there is danger in having to leave the sanctuary, and there will be a need to gather supplies, but once you have a home base the monsters can't enter, it loses a level of stakes. It makes me think of M. Night Shyamalan's Signs where space aliens can travel the stars but cannot open a pantry door. Having limitations on your monsters is essential or else the threat will feel too overwhelming, but these limitations need to make consistent sense. The monsters in A Quiet Place had superior hearing but were essentially blind. The monsters in Bird Box are deadly to look at, will tempt you with auditory siren songs, but as long as one remains indoors and stays away from windows, you can live a happy and healthy albeit sheltered life of repose.
This is one reason why the story has to find a new threat that is allowed to venture into the safe spaces. There are certain people who seem immune to the suicidal impulses of the monsters. The screenplay by Eric Heisserer (Arrival) implies people who were crazy beforehand are unaffected, though what degree of crazy or mental instability is up to interpretation. These people worship the monsters and actively try to force others to look at them, to also be enlightened. This could have been an interesting addition to the world of Bird Box but it plays it too straight. These cultist people are just another obstacle, a group of standard movie crazy killers. I was hoping that the screenplay was playing coy with this subject and biding its time only to introduce this group in a more meaningful and manipulative fashion later. It never happens. They're just crazy killers meant to enter buildings and pose a new indoors threat. Now you can't trust anyone!
The structure of Bird Box constrains the overall impact of its story. The movie is divided almost equally between two different timelines, one shortly after the start of the monster attacks and one five years later. I was waiting for these two different storylines to inform one another, and they do in essentially superficial ways. We know in the future story that it's only Sandy and the kids, so it's only a matter of time before everyone in this house will end up dead. It also hurts that this segment is best described as "dime store Stephen King." We're stuck with a group of strangers who have all been given one note to play, therefore the extra time feels tedious because we don't care about them or what happens to them next (sorry John Malkovich, Jacki Weaver, BD Wong, and others). Winnowing these extended flashbacks and sticking with the current day storyline would have improved the movie. There's a more immediate threat and it presents a more intriguing scenario of being on the run and learning as we go about the monsters and the accrued survival tactics. I think learning on the run would be more exciting rather than conveniently finding refuge with a guy who explains everything because he was doing a book report on the supernatural and somehow knows the rules. This would also better hone the theme because the "before" of our before-and-after dynamic doesn't establish Sandy enough as a disinterested mother.
Much of this could be forgiven or mitigated if the suspense sequences were engaging and smartly developed. I can forgive any nagging plot quibble with A Quiet Place (Why don't they live closer to the waterfall? Why don't they have a sound system to draw away monsters?) because the suspense sequences were brilliantly executed and highly unnerving. This just isn't the case with Bird Box. There is one clever sequence that seems to capitalize on the possibilities of its sight-challenged premise. During the house half, the gang climbs into a car and uses its motion sensors and GPS to navigate a trip to the local grocery store for a supply run. It's fun and decently staged. The inclusion of caged birds being a monster alarm is interesting until it starts to become more ridiculous. People never seem to listen to these birds and pay the price. The initial outbreak in the opening, with cars flipping and people flipping out, has a nice escalation into madness and chaos. The movie never quite recovers that same tense feeling. Watching people wander with blindfolds doesn't make for great visual tension unless we see what they do not and dread what's to come. Bird Box settles into a generic paranoia thriller about who can be trusted, and that's even before the crazy cultists come knocking. Outside in the woods, the final act involves running to sanctuary, but without the killer cultists, it's only running away from a thing that can't touch them. It makes for a curiously inept climax and a sentimental resolution that feels unearned.
The arc of the movie is about Sandra Bullock's character accepting motherhood and attachment to others but this theme is murky. She named her children "Girl" and "Boy" because she didn't want to think of them as her own. This is the kind of thing that seems more symbolic and meaningful in theory than practice. She tells the children that in order to survive in this brave new world that they must be ready to cut another person loose at any moment. Attachments to others will get you killed, or so Sandy argues but not in deed. Because this storyline covers half of the film, the relationship she has with the kids feels underdeveloped but not by Sandy's choice, by the filmmakers. If Sandy's character arc was going to end at the destination of her realizing love is not a detriment even in a horrible, terrifying world, then we needed more time spent on this emotional journey, which is another reason why we could have used more time in the present-day storyline. A degree of self-sacrifice feels missing to better signify the theme of attachment and the emotional stakes.
I reiterate that Bird Box is not worth the strong feelings of love or hate. It's got a wobbly structure where either half fails to better inform the other, the limitations of the monsters guts too much of the tension and stakes, and the actors deserve better. Bullock delivers a strong central performance and serves as our entertainment anchor. She makes the movie more watchable and does her best with some less-than-stellar expository dialogue. It's enough to make you wish this movie was better and better realized with its spooky premise.
Nate's Grade: C
Posted on January 2, 2019, in 2018 Movies and tagged horror, jackie weaver, john malkovich, monsters, motherhood, netflix, rosa salazar, sanda bullock, sarah paulson, sci-fi, strong heroine, tom hollander. Bookmark the permalink.	1 Comment.
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For the fourth consecutive year, the Jason Taylor Foundation is giving the South Florida community the chance to witness the top youth poets in the state compete during a cutting edge event – the Louder Than A Bomb Florida Poetry Festival presented by Nova Southeastern University and UPS. This highly anticipated event takes place from March 26 – April 21, 2018.
Dubbed the "Super Bowl of poetry," Louder Than A Bomb Florida (LTABFLA), a Jason Taylor Foundation arts and education project, features a friendly spoken-word competition between school-based poetry teams representing high schools from across the state. Funding from Nova Southeastern University, UPS and a host of other community partners has assisted the Jason Taylor Foundation support the schools' efforts by providing year-round, in-class and after-school instruction, which will culminate in this 27-day festival.
For the first time in LTABFLA history, a Central Florida preliminary round has been added to the competition and will feature schools representing Brevard, Columbia, Duval, Hillsborough, Orange and St. Lucie counties, while the South Florida regional bracket will be comprised of more than 30 schools from Broward, Miami-Dade and Palm Beach counties.
Since founding the bluapple Poetry Network with actor and poet Omari Hardwick in 2012, the Foundation has helped more than 65 schools activate this program, with more than 1,200 participants inspiring their communities with poetry.Louder Than A Bomb Florida is a festival featuring poetry bouts, workshops, exhibits, and ultimately the crowning of Florida's top youth poetry team. The most critical component, however, is the year-round, meaningful instruction inside the classroom and after-school clubs, with teachers and teaching artists who create and facilitate a safe space for individual and collective expression.In addition to Nova Southeastern University and UPS, other supporters of Louder Than A Bomb Florida include 99 JAMZ, Arts Garage, ArtServe, BBX Capital Foundation, Best Buy of Davie, Broward Schools, Carnival Foundation, City of Miramar, City of Sunrise, Commissioner Keon Hardemon, DeBartolo Family Foundation, Ella Café, Florida Panthers Foundation, Goldman Properties, Heroes of Hip Hop, Hits 97.3, Hoffman's Chocolates, Invicta Watch Group, Jax Youth Poetry Slam, LIME Fresh Mexican Grill, Little Haiti Cultural Complex, Miami Dolphins Foundation, Minuteman Press of Hollywood, Miramar Cultural Center, MOD Pizza, NBC-6, Pavlov's Ring The Bell Management, PlugIN Private Karaoke Rooms, Publix, Savor Cinema, Sonshine Communications, Sports & Activities Directory, StevenDouglas, The Fountains, The Performers Academy, Thunderous Genius Creative House, Ultimate Software, Urban Word, Wizard Creations, YoungArts Foundation, and Young Chicago Authors.
For more information, or to purchase tickets for Louder Than A Bomb Florida events, visit www.bluapplepoetry.org or call (954) 424-0799.


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Evolved RNA Recognition Motifs for Therapeutic and Gene EditingApplications
Award Number: R15GM141783
ORGANIZATION: NATIONAL INSTITUTE OF GENERAL MEDICAL SCIENCES
OPDIV: NIH
AWARD ACTIVITY TYPE: SCIENTIFIC/HEALTH RESEARCH (INCLUDES SURVEYS)
Summary/Abstract. RNA-targeting approaches have received considerable attention, and remain major areas of focus in both basic research and therapeutic development. We have reported TBP6.7, a laboratory evolved U1A-derived RNA Recognition Motif (RRM), that binds HIV-1 trans-activation response (TAR) hairpin (KD ~5 nM), has no endogenous human RNA hairpin targets, and inhibits TAR-dependent transcription. More recently, we reported the 1.8Å crystal structure of the TBP6.7-TAR hairpin complex, which led to structure-guided development of a cyclic peptide inhibitor of TAR-dependent transcription. Researchers have used TBP6.7 as a central component in CRISPR-Cas-Inspired RNA Targeting System (CIRTS), a programmable RNA modifying platform. CIRTS consists of an effector domain, TAR-binding domain (TBP6.7), and a single-stranded RNA shield protein domain. When mixed with a guide strand RNA (gRNA) consisting of a target sequence complementary region flanked by TAR RNA hairpin, sequence-specific mRNA targeting (degradation or gene editing) is achieved. However, a single TBP6.7:TAR binding pair, responsible for forming the necessary CIRTS fusion protein-gRNA complex, dramatically limits number of mRNAs that can be targeted – to one per experiment. Using a structure-guided approach, we will evolve new RRMs that bind TAR-derived RNA hairpins. Following biophysical characterization of these complexes, they will be incorporated into the CIRTS platform and mRNA degradation or gene editing will be measured using standard reporter systems (Dickinson lab). In addition to TAR, we have evolved RRMs that bind the oncogenic precursor microRNA pre-miR-21. Preliminary flow cytometry data indicates that a number of these proteins potently and selectively bind pre-miR-21. We will use ELISA, SPR, and ITC to characterize these new protein-RNA interactions, engineer and test mutant forms of these new RRM-RNA pairs to better understand the requirements for binding, and measure RRM-dependent inhibition of DICER pre-miR-21 splicing. Collectively, this research will lead to the development of new RNA-targeted therapeutic leads, expand our understanding of sequence-selective RNA recognition, and develop new protein-RNA binding partners for incorporation into the mRNA gene editing platform CIRTS – enabling multiplexed editing of specific mRNAs in a single cell. Finally, funding for this research will expand research opportunities for undergraduate and graduate researchers at Delaware State University – an Historically Black College and University (HBCU). Given the makeup of our undergraduate and graduate student population, this research will enrich the training of young researchers and scholars who are historically underrepresented in Science, Technology, Engineering, and Mathematics (STEM).
2022 2022 DELAWARE STATE UNIVERSITY 1200 N DUPONT HWY DOVER DE 19901 KENT USA Biomedical Research and Research Training 000 1 12/30/2021 NEW $438,000

redpajama_set_name: RedPajamaCommonCrawl


it's just Laine: Got Beans?
I found an old bag of "15 bean soup" mix in the back of my cupboard that has been waiting for a crockpot and a ham bone. But alas, I never bought a ham this year and so it continued to sit. Until two weeks ago.
We were having one of "those" days. (Ever have those?) And as I was on the brink of losing my sanity while trying to homeschool and entertain a three year old, I poured the neglected beans into a Sterilite container, added a few dried black beans and gave it to my rambunctious three year old. Caleb sat for 2 hours. TWO WHOLE HOURS. With barely a peep. He played and played with his "digger" and dump trucks and had a blast.
Since then I've added a few medicine cups (you know, the little clear ones you get with Robitussin, etc.) and that has brought even more excitement. He loves to pour the beans back and forth between the cups. My children LOVE playing with this...it is usually the first thing off of the shelf in the morning.
So fellow Mommies, if you are looking for something to keep your little people busy, I highly suggest some dried beans and a plastic container!!
I totally agree about the bin of beans - When the Man-Cub was little - we had a big bin of beans - the kind that slides under the bed and he played with his 'diggers' for hours too.


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Get e-Books "Thanhha Lai Young Readers Collection" on Pdf, ePub, Tuebl, Mobi and Audiobook for FREE. There are more than 1 Million Books that have been enjoyed by people from all over the world. Always update books hourly, if not looking, search in the book search column. Enjoy 100% FREE.
Thanhha Lai Young Readers Collection
Author : Thanhha Lai
Acclaimed New York Times bestselling author Thanhha Lai won the National Book Award for Young People's Literature and the Newbery Honor for her debut novel, Inside Out and Back Again. This collection includes Inside Out and Back Again along with her newest novel, Listen, Slowly. Inside Out and Back Again: Inspired by the author's childhood experience of fleeing Vietnam after the Fall of Saigon and immigrating to Alabama, this coming-of-age debut novel told in verse has been celebrated for its touching child's-eye view of family and immigration. For all the ten years of her life, Hà has only known Saigon: the thrills of its markets, the joy of its traditions, and the warmth of her friends close by. But now the Vietnam War has reached her home. Hà and her family are forced to flee as Saigon falls, and they board a ship headed toward hope. In America, Hà discovers the foreign world of Alabama: the coldness of its strangers, the dullness of its food . . . and the strength of her very own family. Listen, Slowly: Twelve-year-old Mia's parents are sending her, along with her father, on a trip to Vietnam so she can learn more about her roots—and also help her grandmother figure out what really happened to Mia's grandfather during the Vietnam War. Since Mia barely knows the language or customs, she is desperately counting down the days until she can go back home. But the next few weeks are a life-changing experience. As time passes, Mia begins to have a change of heart, growing closer to her family and developing an understanding of a culture and an entire world which that she never really knew about.
Inside Out Back Again
Publisher : Univ. of Queensland Press
Through a series of poems, a young girl chronicles the life-changing year of 1975, when she, her mother, and her brothers leave Vietnam and resettle in Alabama.
Listen Slowly
Listen, Slowly is a New York Times Book Review Notable Book and a Publishers Weekly Best Book of the Year! This remarkable and bestselling novel from Thanhha Lai, author of the National Book Award–winning and Newbery Honor Book Inside Out & Back Again, follows a young girl as she learns the true meaning of family. A California girl born and raised, Mai can't wait to spend her vacation at the beach. Instead, she has to travel to Vietnam with her grandmother, who is going back to find out what really happened to her husband during the Vietnam War. Mai's parents think this trip will be a great opportunity for their out-of-touch daughter to learn more about her culture. But to Mai, those are their roots, not her own. Vietnam is hot, smelly, and the last place she wants to be. Besides barely speaking the language, she doesn't know the geography, the local customs, or even her distant relatives. To survive her trip, Mai must find a balance between her two completely different worlds. Perfect for fans of Rita Williams-Garcia and Linda Sue Park, Listen, Slowly is an irresistibly charming and emotionally poignant tale about a girl who discovers that home and culture, family and friends, can all mean different things.
Butterfly Yellow
Author : Thanhhà Lai
Genre : Young Adult Fiction
Winner of the Scott O'Dell Award for Historical Fiction! Perfect for fans of Elizabeth Acevedo, Ibi Zoboi, and Erika L. Sanchez, this gorgeously written and deeply moving own voices novel is the YA debut from the award-winning author of Inside Out & Back Again. 4 starred reviews! In the final days of the Việt Nam War, Hằng takes her little brother, Linh, to the airport, determined to find a way to safety in America. In a split second, Linh is ripped from her arms—and Hằng is left behind in the war-torn country. Six years later, Hằng has made the brutal journey from Việt Nam and is now in Texas as a refugee. She doesn't know how she will find the little brother who was taken from her until she meets LeeRoy, a city boy with big rodeo dreams, who decides to help her. Hằng is overjoyed when she reunites with Linh. But when she realizes he doesn't remember her, their family, or Việt Nam, her heart is crushed. Though the distance between them feels greater than ever, Hằng has come so far that she will do anything to bridge the gap.
Reading The World S Stories
Author : Annette Y. Goldsmith
Genre : Language Arts & Disciplines
Publisher : Rowman & Littlefield
Reading the World's Stories is volume 5 in the Bridges to Understanding series of annotated international youth literature bibliographies sponsored by the United States Board on Books for Young People. USBBY is the United States chapter of the International Board on Books for Young People (IBBY), a Switzerland-based nonprofit whose mission is bring books and children together. The series promotes sharing international children's books as a way to facilitate intercultural understanding and meet new literary voices. This volume follows Children's Books from Other Countries (1998), The World though Children's Books (2002), Crossing Boundaries with Children's Books (2006), and Bridges to Understanding: Envisioning the World through Children's Books (2011) and acts as a companion book to the earlier titles. Centered around the theme of the importance of stories, the guide is a resource for discovering more recent global books that fit many reading tastes and educational needs for readers aged 0-18 years. Essays by storyteller Anne Pellowski, author Beverley Naidoo, and academic Marianne Martens offer a variety of perspectives on international youth literature. This latest installment in the series covers books published from 2010-2014 and includes English-language imports as well as translations of children's and young adult literature first published outside of the United States. These books are supplemented by a smaller number of culturally appropriate books from the US to help fill in gaps from underrepresented countries. The organization of the guide is geographic by region and country. All of the more than 800 entries are recommended, and many of the books have won awards or achieved other recognition in their home countries. Forty children's book experts wrote the annotations. The entries are indexed by author, translator, illustrator, title, and subject. Back matter also includes international book awards, important organizations and research collections, and a selected directory of publishers known for publishing books from other countries.
Author : Nadia Hashimi
Perfect for fans of Rita Williams-Garcia, Thanhha Lai, and Rebecca Stead, internationally bestselling author Nadia Hashimi's first novel for young readers is a coming-of-age journey set in modern-day Afghanistan that explores life as a bacha posh—a preteen girl dressed as a boy. Obayda's family is in need of some good fortune, and her aunt has an idea to bring the family luck—dress Obayda, the youngest of four sisters, as a boy, a bacha posh. Life in this in-between place is confusing, but once Obayda meets another bacha posh, everything changes. Their transformation won't last forever, though—unless the two best friends can figure out a way to make it stick and make their newfound freedoms endure. Nadia Hashimi's first novel for adults, The Pearl That Broke Its Shell, was a bestseller that shares a bacha posh character with One Half from the East.
Author : Jesmyn Ward
Genre : African American children
Publisher : A&C Black
WINNER OF THE NATIONAL BOOK AWARD 2011
Author : Linda Sue Park
The New York Times bestseller A Long Walk to Water begins as two stories, told in alternating sections, about two eleven-year-olds in Sudan, a girl in 2008 and a boy in 1985. The girl, Nya, is fetching water from a pond that is two hours' walk from her home: she makes two trips to the pond every day. The boy, Salva, becomes one of the "lost boys" of Sudan, refugees who cover the African continent on foot as they search for their families and for a safe place to stay. Enduring every hardship from loneliness to attack by armed rebels to contact with killer lions and crocodiles, Salva is a survivor, and his story goes on to intersect with Nya's in an astonishing and moving way.
Our Story Begins
Author : Elissa Brent Weissman
Publisher : Simon and Schuster
From award-winning author Elissa Brent Weissman comes a collection of quirky, smart, and vulnerable childhood works by some of today's foremost children's authors and illustrators—revealing young talent, the storytellers they would one day become, and the creativity they inspire today. Everyone's story begins somewhere… For Linda Sue Park, it was a trip to the ocean, a brand-new typewriter, and a little creative license. For Jarrett J. Krosoczka, it was a third grade writing assignment that ignited a creative fire in a kid who liked to draw. For Kwame Alexander, it was a loving poem composed for Mother's Day—and perfected through draft after discarded draft. For others, it was a teacher, a parent, a beloved book, a word of encouragement. It was trying, and failing, and trying again. It was a love of words, and pictures, and stories. Your story is beginning, too. Where will it go?
Freewriting With Purpose
Author : Karen Filewych
Genre : Education
Publisher : Pembroke Publishers Limited
In freewriting, we write continuously: we begin with a prompt and keep our pen or pencil moving throughout the entire duration. We do not stop to question or censor ourselves; we do not concern ourselves with spelling, punctuation, capitalization, or grammar; we do not allow critical thoughts. This practical book shows teachers how to use freewriting to help kids write well and more, regardless of grade level, subject, or time of day or year. It is a simple process to implement, and yet makes a significant difference in teacher attitudes, student confidence, and, ultimately, student writing abilities.


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Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage
Csaba Szabo, Gerardo Ferrer-Sueta, Basilia Zingarelli, Garry J. Southan, Andrew L. Salzman, Rafael Radi
Nitric oxide (NO) produced by the inducible nitric-oxide synthase (iNOS) is responsible for some of the pathophysiological alterations during inflammation. Part of NO-related cytotoxicity is mediated by peroxynitrite, an oxidant species produced from NO and superoxide. Aminoguanidine and mercaptoethylguanidine (MEG) are inhibitors of iNOS and have anti- inflammatory properties. Here we demonstrate that MEG and related compounds are scavengers of peroxynitrite. MEG caused a dose-dependent inhibition of the peroxynitrite-induced oxidation of cytochrome c 2+, hydroxylation of benzoate, and nitration of 4-hydroxyphenylacetic acid. MEG reacts with peroxynitrite with a second-order rate constant of 1900 ± 64 M -1 s -1 at 37 °C. In cultured macrophages, MEG reduced the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite. MEG also reduced the degree of vascular hyporeactivity in rat thoracic aortic rings exposed to peroxynitrite. The free thiol plays an important role in the scavenging effect of MEG. Aminoguanidine neither affected the oxidation of cytochrome c 2+ nor reacted with ground state peroxynitrite, but inhibited the peroxynitrite-induced benzoate hydroxylation and 4-hydroxyphenylacetic acid nitration, indicating that it reacts with activated peroxynitrous acid or nitrogen dioxide. Compounds that act both as iNOS inhibitors and peroxynitrite scavengers may be useful anti-inflammatory agents.
https://doi.org/10.1074/jbc.272.14.9030
Guanidine
Nitric Oxide Synthase Type II
Nitration
Hydroxylation
Cytochromes c
2-mercaptoethylguanidine
Mitochondrial DNA
Szabo, C., Ferrer-Sueta, G., Zingarelli, B., Southan, G. J., Salzman, A. L., & Radi, R. (1997). Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. Journal of Biological Chemistry, 272(14), 9030-9036. https://doi.org/10.1074/jbc.272.14.9030
Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. / Szabo, Csaba; Ferrer-Sueta, Gerardo; Zingarelli, Basilia; Southan, Garry J.; Salzman, Andrew L.; Radi, Rafael.
In: Journal of Biological Chemistry, Vol. 272, No. 14, 04.04.1997, p. 9030-9036.
Szabo, C, Ferrer-Sueta, G, Zingarelli, B, Southan, GJ, Salzman, AL & Radi, R 1997, 'Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage', Journal of Biological Chemistry, vol. 272, no. 14, pp. 9030-9036. https://doi.org/10.1074/jbc.272.14.9030
Szabo C, Ferrer-Sueta G, Zingarelli B, Southan GJ, Salzman AL, Radi R. Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. Journal of Biological Chemistry. 1997 Apr 4;272(14):9030-9036. https://doi.org/10.1074/jbc.272.14.9030
Szabo, Csaba ; Ferrer-Sueta, Gerardo ; Zingarelli, Basilia ; Southan, Garry J. ; Salzman, Andrew L. ; Radi, Rafael. / Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage. In: Journal of Biological Chemistry. 1997 ; Vol. 272, No. 14. pp. 9030-9036.
@article{981c39c43d1f473fa0e9e5b3fe3e6462,
title = "Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage",
abstract = "Nitric oxide (NO) produced by the inducible nitric-oxide synthase (iNOS) is responsible for some of the pathophysiological alterations during inflammation. Part of NO-related cytotoxicity is mediated by peroxynitrite, an oxidant species produced from NO and superoxide. Aminoguanidine and mercaptoethylguanidine (MEG) are inhibitors of iNOS and have anti- inflammatory properties. Here we demonstrate that MEG and related compounds are scavengers of peroxynitrite. MEG caused a dose-dependent inhibition of the peroxynitrite-induced oxidation of cytochrome c 2+, hydroxylation of benzoate, and nitration of 4-hydroxyphenylacetic acid. MEG reacts with peroxynitrite with a second-order rate constant of 1900 ± 64 M -1 s -1 at 37 °C. In cultured macrophages, MEG reduced the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite. MEG also reduced the degree of vascular hyporeactivity in rat thoracic aortic rings exposed to peroxynitrite. The free thiol plays an important role in the scavenging effect of MEG. Aminoguanidine neither affected the oxidation of cytochrome c 2+ nor reacted with ground state peroxynitrite, but inhibited the peroxynitrite-induced benzoate hydroxylation and 4-hydroxyphenylacetic acid nitration, indicating that it reacts with activated peroxynitrous acid or nitrogen dioxide. Compounds that act both as iNOS inhibitors and peroxynitrite scavengers may be useful anti-inflammatory agents.",
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T1 - Mercaptoethylguanidine and guanidine inhibitors of nitric-oxide synthase react with peroxynitrite and protect against peroxynitrite-induced oxidative damage
AU - Szabo, Csaba
AU - Ferrer-Sueta, Gerardo
AU - Zingarelli, Basilia
AU - Southan, Garry J.
AU - Salzman, Andrew L.
AU - Radi, Rafael
N2 - Nitric oxide (NO) produced by the inducible nitric-oxide synthase (iNOS) is responsible for some of the pathophysiological alterations during inflammation. Part of NO-related cytotoxicity is mediated by peroxynitrite, an oxidant species produced from NO and superoxide. Aminoguanidine and mercaptoethylguanidine (MEG) are inhibitors of iNOS and have anti- inflammatory properties. Here we demonstrate that MEG and related compounds are scavengers of peroxynitrite. MEG caused a dose-dependent inhibition of the peroxynitrite-induced oxidation of cytochrome c 2+, hydroxylation of benzoate, and nitration of 4-hydroxyphenylacetic acid. MEG reacts with peroxynitrite with a second-order rate constant of 1900 ± 64 M -1 s -1 at 37 °C. In cultured macrophages, MEG reduced the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite. MEG also reduced the degree of vascular hyporeactivity in rat thoracic aortic rings exposed to peroxynitrite. The free thiol plays an important role in the scavenging effect of MEG. Aminoguanidine neither affected the oxidation of cytochrome c 2+ nor reacted with ground state peroxynitrite, but inhibited the peroxynitrite-induced benzoate hydroxylation and 4-hydroxyphenylacetic acid nitration, indicating that it reacts with activated peroxynitrous acid or nitrogen dioxide. Compounds that act both as iNOS inhibitors and peroxynitrite scavengers may be useful anti-inflammatory agents.
AB - Nitric oxide (NO) produced by the inducible nitric-oxide synthase (iNOS) is responsible for some of the pathophysiological alterations during inflammation. Part of NO-related cytotoxicity is mediated by peroxynitrite, an oxidant species produced from NO and superoxide. Aminoguanidine and mercaptoethylguanidine (MEG) are inhibitors of iNOS and have anti- inflammatory properties. Here we demonstrate that MEG and related compounds are scavengers of peroxynitrite. MEG caused a dose-dependent inhibition of the peroxynitrite-induced oxidation of cytochrome c 2+, hydroxylation of benzoate, and nitration of 4-hydroxyphenylacetic acid. MEG reacts with peroxynitrite with a second-order rate constant of 1900 ± 64 M -1 s -1 at 37 °C. In cultured macrophages, MEG reduced the suppression of mitochondrial respiration and DNA single strand breakage in response to peroxynitrite. MEG also reduced the degree of vascular hyporeactivity in rat thoracic aortic rings exposed to peroxynitrite. The free thiol plays an important role in the scavenging effect of MEG. Aminoguanidine neither affected the oxidation of cytochrome c 2+ nor reacted with ground state peroxynitrite, but inhibited the peroxynitrite-induced benzoate hydroxylation and 4-hydroxyphenylacetic acid nitration, indicating that it reacts with activated peroxynitrous acid or nitrogen dioxide. Compounds that act both as iNOS inhibitors and peroxynitrite scavengers may be useful anti-inflammatory agents.
U2 - 10.1074/jbc.272.14.9030
DO - 10.1074/jbc.272.14.9030
10.1074/jbc.272.14.9030


AUGUSTA, Ga. – The 12th hole in Augusta National usually has something to say about who wins the championship. The famous Par-3 turned critical again on Sunday afternoon and opened the door for Tiger Woods to receive his fifth green jacket.
Four players from the last two groups found water in 12th, including Francesco Molinari Woods, who was two shots ahead. Tony Finau, also in dispute and playing with Woods and Molinari, found the water as well as Brooks Koepka, who was in the group in front of Woods. All suffered double on the hole while Woods scored a par. He left the hole with Molinari at 11, while Koepka was 9 below and Finau from 10 to 8 below.
3th, Woods took his first lead Sunday at the Masters since making birdie on the 15th in 2005 and breaking a jam of competitors who had blocked the rankings.
"This mistake Francesco made there has taken many guys into the tournament," Woods said. "There were so many different scenarios that could have happened in the last nine years. There were so many people who had a chance to win. The ranking was absolutely full and everyone was playing well. They could not have had more drama than we all had outside. Now I know why I'm bald. This stuff is tough.
"I think we have decided to shoot for the right and just not hit hard enough, "he said. "It was a tough day with the wind today. I managed to climb well in the first nine. I just had some mental failures on the last nine that were costly. "
Molinari, who held the 54-hole lead with two strokes, brought the ball into the water after par 15 on the 15th. He landed Sunday with a 2 over 74 and finished 11 under two, two strokes behind Woods. Koepka was 12 under and Finau 11 under.
"I knew from then on that I had to play pretty perfect golf," Finau said. I could have done something all the way, but 12 was a kind of swing. "
Koepka, who was aiming for the par 5-13 eagle cruiser, said the wind hit his ball on the 12th.
"Once it's over these trees, it's just a guessing game," he said.


text:
Q: Overriding Exception.Message / exception pattern matching I'm trying to pattern match on an exception within its definition. Is something like the following possible using F#'s exception syntax, or must I subclass Exception?
This is what I expected to work:
exception CoordErr of int * int
    with
        override this.Message =
            let CoordErr(x, y) = this
            sprintf "(%i %i)" x y //ERROR

But yields the errors:

The value or constructor 'x' is not defined
  The value or constructor 'y' is not defined

EDIT
I also tried adding parens:
let (CoordErr(x, y)) = this

But this gives the error:

This expression was expected to have type exn but here has type CoordErr

UPDATE
The following works, but isn't ideal:
exception CoordErr of int * int
    with
        override this.Message =
            sprintf "(%i %i)" this.Data0 this.Data1

Is there another way to do this?
UPDATE 2
Taking a cue from kvb's answer, I suppose I could do the following to swallow the incomplete matches warning:
exception CoordErr of int * int
    with
        override this.Message =
            match this :> exn with
            | CoordErr(x, y) -> sprintf "(%i %i)" x y
            | _ -> Unchecked.defaultof<_>

A: Your first attempt doesn't work because you're defining a let-bound function called CoordErr which shadows the exception constructor, which isn't what you want.
Your second attempt almost works.  Unfortunately, exception definitions don't work quite like discriminated unions: when pattern matching against an exception constructor, the expression that you're matching has to be of type exn (and not of the specific exception subtype).  In your case, you are trying to match this (of type CoordErr) against the CoordErr constructor.  How's this for a workaround?
exception CoordErr of int * int
    with
        override this.Message =
          let (CoordErr(x,y)) = upcast this
          sprintf "(%i %i)" x y

A: Naming the constructor arguments and accessing the corresponding fields seems to work:
exception CoordErr of x : int * y : int
    with
        override this.Message =
            sprintf "(%i %i)" this.x this.y

I realise this is not a pattern-matching solution, but it does answer the "Overriding Exception.Message" part of your question. :)

A: You could use the exception aware pattern matching of a try with expression
exception CoordErr of int * int
    with
        override this.Message =
            try raise this with CoordErr(x, y) -> sprintf "(%i %i)" x y

redpajama_set_name: RedPajamaStackExchange


Ever wonder what goes into the tour your favorite band just went on and the show they just played?! Check out what the tour manager for a fantastic live band had to say about her job and the day to day aspects of touring!
The second band to be featured as the spotlight band of the week is… Set it Off!
They have really caught my attention on numerous occasions with their hard work and dedication as well as their theatric live performances.
The first band to be featured as my spotlight band of the week is The Word Alive! Not only did they catch my attention with their live performance but they have given me the idea to showcase bands that do something that needs to be spoken about. I covered the unconditional tour for Make Waves where The Word Alive is touring as direct support to Memphis May Fire and it was a show I won't soon forget!
New to Edge of the Dream!
There's so many great bands out there but some just really stand out; whether it be for a new album, great live performance, or anything that really catches my attention I want to showcase a different band every week in my new "spotlight" category!
A new band will be in the spotlight on Mondays when something needs to be spoken about! Check back later to see what band has been the inspiration for the new column on Edge of the Dream as they will be the first in The Spotlight !


text:
Home |News & Opinion | News
Report: Homeschoolers Much More Diverse Than Previously Thought
By Vivian E. Jones
About 26 percent of U.S. homeschooling families—more than 400,000—are Hispanic, and 8 percent—about 130,000 families—are black, National Center for Education Statistics data show.
Homeschooled students, and the educational opportunities available to them, are becoming more diverse than ever, a new study from the Center on Reinventing Public Education (CRPE) states.
"Black families are increasingly rejecting traditional district schools in favor of homeschooling," writes Aaron Hirsh in his CRPE policy brief on "The Changing Landscape of Homeschooling in the United States," released July 22.
"The homeschooling community includes Muslim and Jewish families, military families, families of gifted students and of those with special needs," Hirsh writes. "Homeschoolers run the political spectrum from left to right and the economic spectrum from wealthy to poor."
Estimates of the number of homeschooled students in the United States range from two million to three million.
"While only 3 percent of K-12 students in the United States are homeschooled, this percentage has grown since 1999 and shows signs of continuing to increase," Hirsh writes.
Dissatisfied with Government Schools
Homeschooling was once perceived as a niche educational alternative practiced largely by conservative white families for religious reasons, but homeschoolers today come from many backgrounds, says Aaron Smith, director of education reform at the Reason Foundation.
"The fact is that homeschool families are much more diverse than commonly believed, and there are many reasons parents are increasingly choosing this option," Smith said.
"Motives for opting out vary, but many black families cite racism and a lack of opportunity for black students in the traditional classroom," Hirsh writes.
There hasn't been much research on why some types of families are choosing to homeschool, according to Hirsch.
"Almost no scholarly research has been conducted on the motivations and practices of Hispanic families who choose to homeschool," Hirsh writes.
Parents could be prompted by the failure of the default option, Smith says.
"One reason is dissatisfaction with the performance of their zoned public school," Smith said.
Innovative Teaching
Today's homeschooling families are not limited to teaching at the dining room table. In many communities, parents have several choices of independent micro-schools or interfamily cooperatives where their children can attend classes taught by parents or others with expertise in their subject of instruction.
In addition to specialized cooperative class opportunities, many communities offer homeschoolers extracurricular activities such as varsity sports teams, robotics clubs, and mock trial and debate teams.
High school homeschooled students also take college-level classes offered by local universities and community colleges, earning dual enrollment credits for both high school and college. A multitude of courses are also available online for students in kindergarten through 12th grade.
'Force for Change'
Traditional education cannot meet the needs of all students, says Luther, Oklahoma Mayor Jenni White, cofounder and director of education for Reclaim Oklahoma Parent Empowerment.
"Classroom teaching will, unfortunately, always have the limitation of being unable to provide an equitable education to every child in the classroom because children are individuals who intellectually and emotionally differ from one another," White said. "This is the exact reason homeschooling is such a force for change in education."
One-on-one teaching is the most effective form of education, White says.
"When you make the opportunity to meet a child at their level with whatever curricula or method—online, in person, visiting museums, experimentation—you're able to utilize, that child truly learns the lessons that might completely escape him with a teacher who has limited classroom time," White said.
Meets Individual Needs
The wide range of options available to parents to customize education to their child's specific needs has proven a great service to the individual student, particularly those with special needs, White says.
"Our youngest son was doing very poorly in his first-grade class and unable to keep up with math, specifically," White said. "He would come home with poor grades, and his teacher would badger both him and me about his poor performance, which only added to the stress of the situation for both of us."
When the White family chose to homeschool, they discovered their son had a form of dyslexia which made mathematics especially challenging, White says.
"Once we identified the problem, we were able to find assistance and rectify it," White said. "I'm still uncertain if this discovery would ever have occurred had he stayed enrolled in public school."
Of the six states that have Education Savings Accounts, three allow families to use ESA funds for homeschooling students with disabilities: Florida, North Carolina, and Tennessee. Only Nevada allows ESA funds to be used for homeschooling without restrictions. Arizona families may use ESA funds for homeschooling of students who meet certain eligibility requirements.
Allows Customized Education
Homeschooling is innovative and less restricted than traditional schools, White says.
"Homeschooling allows parents to customize a child's education to their unique needs and interests, which largely isn't possible in a traditional setting," Smith says. "It also opens up a robust menu of learning opportunities that might otherwise be restricted or unavailable, such as regular field trips, customized projects, and quality curriculum."
Vivian E. Jones (vivianejones@aol.com) writes from Murfreesboro, Tennessee.
Internet Info:
Aaron Hirsh, "The Changing Landscape of Homeschooling in the United States," Center for Reinventing Public Education, July 22, 2019: https://www.heartland.org/publications-resources/publications/report-the-changing-landscape-of-homeschooling-in-the-united-states
Sub-topic
Education: Home Schooling
Related News & Opinion View All News
Bernie's Education Plans are Bonkers
Organization Tracks Lawsuits Challenging Colleges' Sexual Misconduct Policies
By Ashley Bateman


text:
rhingo
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Why You Should Be Careful About 23andMe's Health Test
Their test is F.D.A. approved, but that doesn't necessarily mean it's useful.
1 Comments in
via www.nytimes.com
How I let drinking take over my life
The long read: Five years after his last taste of alcohol, William Leith tries to understand its powerful magic
discuss in
via www.theguardian.com
Analysis rhingo
Bees can count with just four nerve cells in their brains
Bees can solve seemingly clever counting tasks with very small numbers of nerve cells in their brains, according to researchers at Queen Mary University of London.
via www.qmul.ac.uk
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Men In Black: International - Official Trailer
movietrailers
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Tribe creation The maximum amount of tribes you can create has been raised by 2 to a total of 17.
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NSFW: Vietnam's dog meat culture clashes with modern tastes [GRAPHIC]
Vietnamese officials in Hanoi have asked residents to stop eating dog meat, citing health and public image concerns. Vendors and enthusiasts now fear a nationwide ban on what they consider to be a traditional delicacy.
via www.dw.com
Astronomers may have discovered the first moon ever found outside our Solar System
A pair of astronomers believes they've found a moon orbiting a planet outside our Solar System — something that has never before been confirmed to exist. Though they aren't totally certain of their discovery yet, the find opens up the possibility that more distant moons are out there. And that could change our understanding of how the Universe is structured.
via www.theverge.com
House passes bill to require minimum standards for airplane seat size, legroom
The House passed a bill that would require minimum airplane seat sizes and configurations. The clause was part of a five-year extension of the Federal Aviation Administration.
via www.cnbc.com
The tragic end of Telltale Games, as told by the people who were there
How an award-winning studio abruptly shuttered.
pcgaming
1rulebecool
Russian President Vladimir Putin arrives in India today, likely to sign 20 agreements
India and Russia are likely to sign about 20 pacts in areas ranging from defence, nuclear energy, space and economy during Russia's President Vladimir Putin's two-day visit to India from Thursday. Putin is scheduled to meet Prime Minister Narendra Modi on Friday.
via indianexpress.com
Carlsberg glues beer cans together becoming one of the first breweries to abandon plastic rings
arlsberg beer cans are to be stuck together with glue as it becomes one of the first brewers to abandon plastic rings. The Danish firm said the move, which has been heralded as a world-first, to attach its multi-packs with adhesive will reduce the use of plastic to package products by 75 per cent. After a three-year development process, Carlsberg insists the dots of glue bonding its new "Snap Packs" are strong enough to withstand journeys from shelves to homes, yet sufficiently brittle...
via www.telegraph.co.uk
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Manta rays' food-capturing mechanism may hold key to better filtration systems
CORVALLIS, Ore. – Manta rays strain their tiny food from mouthfuls of seawater in a novel way that could hold the key to better filtration in a variety of commercial applications, new research by Oregon State University shows. Published today in Science Advances, the findings explain that manta rays filter zooplankton, mesoplankton and microcrustaceans with an apparatus different from anything previously seen in any biological or industrial system.
marinelife
via today.oregonstate.edu
Atheists think Sinead O'Connor is owed an apology, and then some
Irish singer Sinead O'Connor has been a longtime critic of the Catholic Church and as more and more scandals continue to come to light, some have wondered if O'Connor is owed some sort of an apology. In 1992, the Irish singer made headlines when she tore up a picture of Pope John Paul II and said: "Fight the real enemy" during a performance of her song War on Saturday Night Live.
via www.irishcentral.com
Tiger Woods wins a PGA Tour event for the first time since 2013
Tiger Woods has won a PGA Tour event for the first time in over five years after victory at the Tour Championship. The 14-time major winner's triumph at Atlanta's East Lake Golf Club was his 80th on the PGA Tour and his first since August 2013. Woods finished 11-under par for the weekend, two strokes clear of his nearest challenger Billy Horschel.
via www.cnn.com
Google admits it lets hundreds of other companies access your Gmail inbox
Google is allowing hundreds of companies to scan people's Gmail accounts, read their emails and even share their data with other firms, the company has confirmed. In a letter to US senators Susan Molinari, Google's vice president for public policy in the Americas admitted that it lets app developers access the inboxes of millions of users – even though Google itself stopped looking in 2017.
corporategreed


text:
Événements

Pièces de théâtre publiées
 L'Affaire () d'Aleksandre Soukhovo-Kobyline (Leipzig)

Pièces de théâtre représentées
 3 avril : L'Amour en sabots d'Eugène Labiche, au Théâtre des Variétés
 21 octobre : Le Beau Narcisse, vaudeville des Frères Cogniard et Eugène Deligny, au théâtre des Variétés
 18 novembre : On ne badine pas avec l'amour, comédie d'Alfred de Musset, à la Comédie-Française
 28 décembre : Les Mille et un Songes, revue-féérie des Frères Cogniard et Monsieur Clairville, au théâtre des Variétés

Récompenses

Naissances

Décès
 20 février : Eugène Scribe

Voir aussi
 L'année 1861 dans tous les domaines.
 1861 en littérature

XIXe siècle au théâtre
Theatre

redpajama_set_name: RedPajamaWikipedia


text:
Q: DRF SerializerMethodField: 'obj' argument vs. self.instance What is the difference between self.instance and the argument obj in a Django REST Framework's SerializerMethodField?
Per the documentation of SerializerMethodField it discusses the obj argument:

The serializer method referred to by the method_name argument should accept a single argument (in addition to self), which is the object being serialized.

and also per the documentation of Serializers it discusses self.instance:

When passing an initial object or queryset to a serializer instance, the object will be made available as .instance. If no initial object is passed then the .instance attribute will be None.

Do they refer the same object then?

A: The obj parameter that is passed to your method is based on the source argument to your SerializerMethodField.
Generally the source argument is just "*" and, "*" indicates to the serializer to pass the instance to the method.  If instead you set source="date_joined" on your SerializerMethodField, then your get_days_since_joined might look like this instead:
def get_days_since_joined(self, date_joined):
    return (now() - date_joined).days


Born in 1956 in Santiago, Chile, Jaar lived with his family in Martinique from the age of five to 15 and is now based in New York. Always thoughtfully researched and often with community cooperation, Jaar's projects bear witness to inequalities and injustices around the world such as toxic pollution in Nigeria, gold mining in Brazil and genocide in Rwanda.
Jaar's work has been exhibited extensively around the world and he has participated in the Venice and Sao Paulo Biennales numerous times since the 1980s, as well as Documenta in 1987 and 2002. Alongside many solo exhibitions, he has realised over 60 public interventions around the world and his work is held in important collections including the Guggenheim Museum, New York, the MCA in Chicago, and Tate, London. He became a Guggenheim Fellow in 1985 and a MacArthur Fellow in 2000.
The Garden of Good and Evil was commissioned to coincide with the major exhibition of the same name at YSP in 2017 by Chilean-born artist Alfredo Jaar.
Watch pioneering Chilean artist, Alfredo Jaar and YSP Director of Programme, Clare Lilley discuss 'The Garden of Good and Evil' at the Park.


Adaptive Riding is recreational horseback riding lessons for individuals with special needs. Riders learn horsemanship and riding skills in an environment that is custom-tailored to their needs and learning styles.
We work with the rider and their family to set measurable long-term goals for their progress. The goals for those in the adaptive riding program are riding-skill as well as therapeutically based. These benefits include improvements in physical strength, balance, coordination, mobility, self-confidence, self-control, peer interaction, and social skills.
While we set long term goals, one of the benefits of choosing Scooter's Place is that we take each lesson as it comes. Wherever the student is on that particular day is where we work. We know that, especially children on the spectrum, but even people working through physical challenges, have good days and bad days – a bad night's sleep, changes in the home environment, additional therapies that are leaving them tired, or even a reaction to a gray day. It is important to us to keep the lesson fun and stimulating regardless of the type of day the rider is having. If that means moving backward a bit on the progress that had previously been made, there is nothing wrong with that. If that means that they don't even get on the horse but do activities with a horse nearby or participate more in some grooming, that's where we take the lesson. For children, we work very interactively with their parents to determine daily goals to help keep their session productive but don't leave the child too tired to participate in the rest of their day.
Adaptive riding lessons often incorporate games and exercises designed to meet each student's needs. The goal is to keep the time fun and diverse and to disguise therapeutic movements as games and play time. Sword fights and balloon tosses are favorite activities, as are egg hunts, ornament decorating, and even leprechaun clean up.
Why does horseback riding work?
The combination of the rider's posture and the horse's walking rhythm and three-dimensional movement help to improve circulation and muscle tone for the rider. The disciplines used in working with a large animal and the progress through varied skills, create a feeling of accomplishment and pride in the rider. Horses are willing and non-judgmental, which helps to create a bond between horse and rider that is indescribable.
During riding, the horse's movement naturally mimics a person's motion while walking. This repetitive motion cannot be duplicated by machines or in physical therapy. In this way, the horse aids in relaxing the rider's muscles and increasing his or her balance and flexibility.
In addition, every rider has between 2 and 5 people helping guide them through the lesson. These volunteers are supportive, upbeat, and 100% focused on the lesson at hand. This focus can help with the rider's social skills, provide distraction from potential discomfort or fear, and can provides up to five sets of eyes on areas of improvement and of success. Our volunteers are completely committed to the success of each lesson and many form firm friendships with the riders and their families.


I have a Healthy Habits theme coming up in my preschool classroom for the next couple of weeks. The other teacher of four year olds and I wanted to swap sensory bins after a week so I wanted to come up with something fun that was not terribly messy since the other bin involves messy fun with pretend teeth and brushing.
I searched a bit around and discovered a photo of a spaghetti themed sensory bin. I also looked into using real spaghetti but that seemed a bit too messy for this time around and would probably involve making new spaghetti each day, which I did not really want to sign up myself as well as my fellow teacher to do.
I checked out our pom poms supplies and discovered a lack of large brown ones for meatballs and not much in the way of small ones for cheese so I headed off to the craft store. Unfortunately there were no brown pom poms to be found there and only mixed sets that might have yellow so I needed another solution.
In comes the pom pom maker I saw in the crochet and knitting aisle. I picked this Clover brand one up and found it very easy to use. (You can use my affiliate link to see more details about it from Amazon.) In the past I have made those cardboard rings to make pom poms and felt like I did not make ones that were uniform or well tied. So far, so good with these ones. I will do an update after a week of use by preschoolers to let you know how they fare.
Next up is cutting off white yarn into foot long sections to look like spaghetti. My yarn actually came from the mill ends section of the local craft store, unlike the white yarn pictured above, since I already had it on hand from another project. My inspiration used real pasta, but not spaghetti. Since we have had real pasta as well as real spaghetti in the sensory bin before this year, I wanted to try something new.
For sauce I pulled out some red felt and cut it into organic looking blobs. We will see what the kids think of that tomorrow when we have our first day of school this week.
I also created some quick meatballs with alphabet letters and numbers on them for some review activities. My plan is for the students to pull out a letter with a tool and then make that letter with one of the yarn spaghetti noodles on the plate. With the numbers I was thinking the students could make a plate with that many yarn meatballs or that many spaghetti pieces. I found a similar idea for kindergarten students with words on Mrs. Bremer's Class blog.
Can't have a spaghetti sensory bin without this song. I need to remember to teach this one to my students tomorrow.
I am looking forward to seeing what my preschoolers think of this spaghetti sensory bin tomorrow. What is in your sensory bin this week?


text:
Created on Saturday, 07 November 2009 13:30
Health Department H1N1 Saturday Clinic Vaccinates More than 2,200
The Marion County Health Department vaccinated 2,272 individuals during today's clinic held at Warren Central High School.
The Warren Central clinic was the fourth sponsored by the health department and brought the four-clinic total of people vaccinated to 11,648.
"We were able to offer the vaccine at various times during the day, in the evening, on the weekend and from two locations to make the vaccine accessible to as many in the at-risk group as we could," said Virginia A. Caine, M.D., director, Marion County Health Department. "We would always like to vaccinate more, but feel good about this initial step," Dr. Caine added.
While looking for additional opportunities to hold large, public clinics, the health department will begin vaccinating elementary school-aged children Monday. Local health officials will work in ten schools per day for the next two weeks. Middle school and high school students will be vaccinated in early December. The ultimate goal is to offer the vaccine to a majority of school-aged children in Marion County by the end of the year.
All health department clinics are based on the availability of vaccine. Any vaccine production or delivery delays could impact the school-based H1N1 vaccination plan.
Those with flu-related questions are asked to call the health department's 221-3366 Flu Helpline. The bi-lingual helpline is available Monday through Friday from 8 a.m. until 5 p.m. Those contacting the helpline after hours will have their call returned the next business day.


text:
function [tile_names] = generateClassRandomTiles( image_fullfname, class_label, ...
    number_tiles, tile_size, factor, mask_fullfname, tiles_path)
%% generateClassRandomTiles - generating random tiles from a given class
%   image_fullname - the full name of the image to generate tiles from
%   class_label - the class from which we want randowm tiles
%   number_tiles - the desired number of tiles
%   tile_size - vector for 2 elements- the number of rows and columns of the tile
%   factor - the factor for the minimum number of pixels from all pixels with given label
%   mask_fullfname - the full names of the binary mask corresponding to
%                    the class label (1:'BuiltUp', 2: 'NonBuiltUp' or 3: 'Slum')
%   tiles_path - the main filder for the tiles to be saved in subfolders
%
%   tiles - the full filenames of the tiles
% For Testing use test_generateRandomTiles. See also nonSlumTiling.m

%% input control
if nargin < 7
    error('nonSlumTiling: not enough input arguments!');
end

%% params -> vars

% basename and extention for the tiles
[~,base_fname,ext] = fileparts(image_fullfname);
ext = ext(2:end);

%% initializations
tile_names = {};

%% load the data from the files
image_data = imread(image_fullfname);
mask = imread(mask_fullfname);
[nrows, ncols] = size(mask);

% f = figure;
% subplot(221); imshow(image_data);axis on;grid on;title('Image data');
% subplot(222); imshow(mask);axis on;grid on;title(['Mask for ' class_label ' class']);

%% dimensions
nrows_tile = tile_size(1); ncols_tile = tile_size(2);
half_nrows_tile = fix(nrows_tile/2); half_ncols_tile = fix(ncols_tile/2);

%% generate valid 'strict' mask locations and an image tile
i = 0;
total_num = nrows_tile * ncols_tile;
%rng(0,'twister');

while i < number_tiles

    % generate random pixels
    min_r = half_nrows_tile + 1;
    max_r = nrows - min_r;
    pr = fix((max_r-min_r)*rand + min_r);

    min_c = half_ncols_tile + 1;
    max_c = ncols - min_c;
    pc = fix((max_c-min_c)*rand + min_c);

    % tile extent
    sr = pr - half_nrows_tile;
    er = sr + nrows_tile -1;
    sc = pc - half_ncols_tile;
    ec = sc + ncols_tile - 1;

    % check if the central pixel of a tile belongs to a mask
    if mask(pr, pc)
        % get the mask tile
        tile_mask  = mask(sr:er, sc:ec);
        % determine if the tile satisfies the strict condition
        num_class = sum(tile_mask(:));
        % if it is mark the location in the strict mask
        if num_class/total_num >= factor
            i = i + 1;
            extent = [sr er sc ec];
            image_tile  = image_data(sr:er, sc:ec, :);
            % save
            tile_name = saveTile2File(image_tile, extent, tiles_path,...
                class_label, base_fname, ext);
            tile_names{i} = tile_name;
        end
    end
end

redpajama_set_name: RedPajamaGithub


text:
Fanduel Sportsbook Promo Code June 2020.
Fanduel Sportsbook Promo Code June 2020. Every day, promogains.com serves up the latest coupon code and deals from FanDuel. You are in the right place looking for real and verified Fanduel Sportsbook Promo Code for June 2020. We feature the best deals online including up to 100% off for you and help you to spend less on products you want. Choose from our 50 verified Fanduel Sportsbook Promo.
FanDuel through its daily fantasy offering has exploded in popularity and visibility in the last few years. They now bring a recognizable and trusted brand to New Jersey's legal sports betting market. Recently acquired by the European gambling giant Paddy Power Betfair, they launched their online sportsbook in New Jersey in September 2018 and have been taking bets at their physical sportsbook.
I've deposited on Fantasy instead of. - FanDuel Sportsbook.
However, FanDuel Sportsbook does not seem to have a problem with this, as all deposit methods are eligible for the first deposit bonus. Whether one chooses to deposit directly from a bank account or credit card or using one of the other services such as PayPal, the operator will pay out the bonus should the player's first bet end up being a losing one.FanDuel Casino PA promotions. Visit FanDuel Online Casino's promotions page in Pennsylvania and you will find a wide variety of offers for the app's integrated casino, sportsbook and DFS products. From cash-back offers to prize draws and a generous loyalty program, FanDuel Online Casino PA has plenty of daily, weekly and monthly promotions. The FanDuel Online Casino loyalty program is.FanDuel Sportsbook has been a hit since launching in Indiana in September 2019, with the mobile component falling into place just over a month later. Here's a breakdown of what new users can expect from FanDuel Sportsbook Indiana, and how it compares to the competition. Deposit Bonus: FanDuel Sportsbook Indiana.
Along with the initial deposit bonus, FanDuel Sportsbook also offers some incredible promotions periodically. They include options like: Daily Odds Boosts. Inflated odds on a particular side or total in an event gives players an advantage over the book. There is usually a betting limit associated with these, but they present incredible value to the bettor. In the example below, FanDuel was.FanDuel sportsbook sign-up bonus. FanDuel sportsbook has some great sign-up bonuses that you will want to be aware of before you sign up. For starters, our FanDuel Sportsbook review found FanDuel.
FanDuel Sportsbook is now available in the New Jersey, Pennsylvania, West Virginia, Indiana and Colorado sports betting markets. The company that made its brand through daily fantasy sports moved into the legal sports betting industry in July 2018. FanDuel partnered with the Meadowlands Racetrack in East Rutherford, NJ, to bring a retail sportsbook to the Garden State.
Visit the FanDuel Sportsbook, sign up for a FanDuel account (This bonus offer is only open to bettors who are at least 21 years of age. You must be physically present in Colorado to qualify). Make your first deposit in your account to start betting; If you win your first bet, your winnings will reflect in your account.
The promotions are obtained through a support agent or FanDuel No Deposit Bonus Code. Free money is rewarded to players at no cost of their own, which is enticing for anybody that bets online. However, these sorts of promotions often come with stricter terms of conditions that aren't maintained with standard bonuses. This means a higher wagering requirement at 50x, and longer delays in.
FanDuel Sportsbook And Daily Fantasy Reivew - Bonus Code.
FanDuel Review. FanDuel Sportsbook is legal in Colorado, New Jersey, Pennsylvania, Indiana and West Virginia. The company — which you probably know from being one of the leaders in the daily fantasy sports space — is owned by Paddy Power BetFair, one of the largest gaming conglomerates in the world. FanDuel is not a scam and it most definitely is legit, as it is required to follow the.
Contact Sportsbook support for a return of your Sportsbook deposit. Contact Fantasy support for a return of yoru Fantasy Deposit. Please keep in mind that refunded deposits will forfeit any related deposit bonus. We hope in future to provide shared wallets with winnings available across all of our products, for as many of our customers as possible.
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FanDuel opened its first physical sportsbook in July of 2018 and shortly after, their online sportsbook was launched. Back in 2016, FanDuel and DraftKings agreed to merge, however, after the Federal Trade Commission threatened litigation over the deal because it would create a monopoly, the merger agreement was terminated in 2017, allowing Paddy Power to swoop shortly after.
In general, deposit will be instantaneous whereas withdrawals can take between 3-7 days based on the method prescribed. Deposit and withdrawal limits may apply. FanDuel Customer Service. The FanDuel Sportsbook Michigan is expected to provide customer service in four different ways: Live Chat; Email; Phone (toll-free number) Regular mail.
If you make your way to the Meadowlands Racetrack in East Rutherford, NJ, you can go to the FanDuel Sportsbook desk at the Victory Bar and deposit cash into your FanDuel Online Sportsbook account. Deposit hours are 12 pm-11 pm weekdays; 9 am-11 pm Saturdays and Sundays.
FanDuel Sportsbook Review: Why It Dominates The Market.
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FanDuel Sportsbook was established in 2018, making this a relatively new addition to the sports betting world. It entered with a bang, instantly cementing itself at the top through its an excellent web-based and mobile platform. As is the requirement with New Jersey-based regulated sites, FanDuel receives its license via the Meadowlands Racetrack, which is near MetLife Stadium.
Get ready to place your bets, Hoosiers. FanDuel Sportsbook has come to Indiana. FanDuel Indiana launched in October 2019 to become the latest fantasy site to expand its offering to include traditional sports betting. Parent company Betfair Interactive US (which itself is a subsidiary of international gaming giant Flutter Entertainment) is partnered with Blue Chip Casino in Michigan City and.


text:
Colaptes melanolaimus, "guldbröstad hackspett", är en fågel i familjen hackspettar inom ordningen hackspettartade fåglar. Den betraktas oftast som underart till grönbandad hackspett (Colaptes melanochloros), men urskiljs sedan 2014 av IUCN och Birdlife International som egen art. Den kategoriseras av IUCN som livskraftig.

Arten delas in i tre underarter med följande utbredning:
 C. m. melanolaimus (Malherbe, 1857) – arida höglänta dalar i centrala och södra Bolivia
 C. m. nigroviridis (C. H. B. Grant, 1911) – södra Bolivia, västra Paraguay, norra och östra Argentina (söderut till Córdoba och Buenos Aires) samt västra Uruguay
 C. m. leucofrenatus Leybold, 1873 – nordvästra och västcentrala Argentina (söderut till Neuquén och västra Río Negro).

Noter

Externa länkar

Hackspettar
Fåglar i neotropiska regionen
Colaptes


text:
Home Anderson County Williamston Hillcrest members share Gospel in India
Hillcrest members share Gospel in India
By Larry Baldwin/David Meade
Five members of Hillcrest Baptist Church of Williamston recently traveled to India for a mission trip where they shared the Gospel and saw and did some exciting things. The trip was during the week of September 25-Oct. The mission team, Rev. Larry Baldwin, Debbie Creamer, Leon Brown, Dolly Ford, and Fran Cooley ministered south of Delhi at a colony called Mahipalpur.
While there, they prayer walked through a Sikh temple and visited several Hindi temples, one of which was the temple of Hanuman, the Hindu monkey god in Chatarpur.
The team also participated in a ministry that is called the Luke 10 ministry, which involves walking down streets, stopping and sharing with the people that they meet. "Many times we were invited into homes where we shared our faith and accepted the hospitality of a very friendly culture," Rev. Baldwin said.
During one outing, they traveled five miles southwest to a church in the village of Karnal. Ford and Cooley discipled the women of the church while Rev. Baldwin and Brown taught the men how to share their faith. On Thursday, Oct. 3rd, the team traveled to Agra to visit the Taj Mahal.
When asked, "Why do you think you have to go 8000 miles to the other side of the world to share the Gospel? There are people right here in our area that needs Christ," Rev. Baldwin said, "You're exactly right, there are people here that need Christ in their lives. But the reason we go there also is because when Hillcrest Baptist Church does missions, I want to do it Biblically. Christ said in Matthew 28:19-20 – the Great Commission, "Therefore go and make disciples of all nations, baptizing them in the name of the Father and of the Son and of the Holy Spirit, and teaching them to obey everything I have commanded you. And surely I am with you always, to the very end of the age."
Balwin said, "Also in Acts 1:8 we are told this: "But you will receive power when the Holy Spirit comes on you; and you will be my witnesses in Jerusalem, and in all Judea and Samaria, and to the ends of the earth." Hillcrest has mission projects going on in the Williamston area (our Jerusalem), we go in-state and out-of-state every year (Judea and Samaria) and also out of the country (the ends of the earth)."
"Everyone can be involved in missions," he said. "No matter how young or old. If you're not able to be involved physically, you can still "give" and "pray!"
Rev. Baldwin stated that he is "so humbled to be a part of such a mission minded church." If you would like to be involved or know more about what God is doing through the mission efforts of Hillcrest Baptist Church, contact the church office at 847-7521.
hillcrest baptist church
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text:
package pneumaticCraft.api.recipe;

import java.util.ArrayList;
import java.util.List;

import net.minecraft.block.Block;
import net.minecraft.item.Item;
import net.minecraft.item.ItemStack;

public class AssemblyRecipe{
    public static List<AssemblyRecipe> drillRecipes = new ArrayList<AssemblyRecipe>();
    public static List<AssemblyRecipe> laserRecipes = new ArrayList<AssemblyRecipe>();
    public static List<AssemblyRecipe> drillLaserRecipes = new ArrayList<AssemblyRecipe>();

    private final ItemStack input;
    private final ItemStack output;

    public AssemblyRecipe(ItemStack input, ItemStack output){
        this.input = input;
        this.output = output;
    }

    public ItemStack getInput(){
        return input;
    }

    public ItemStack getOutput(){
        return output;
    }

    public static void addDrillRecipe(Object input, Object output){
        drillRecipes.add(new AssemblyRecipe(getStackFromObject(input), getStackFromObject(output)));
    }

    public static void addLaserRecipe(Object input, Object output){
        laserRecipes.add(new AssemblyRecipe(getStackFromObject(input), getStackFromObject(output)));
    }

    private static ItemStack getStackFromObject(Object object){
        if(object instanceof Block) {
            return new ItemStack((Block)object);
        } else if(object instanceof Item) {
            return new ItemStack((Item)object);
        } else {
            return (ItemStack)object;
        }
    }

}


text:
Ethiopia arrests 5 S. Sudanese, seizes 300,000 SSP, illegal firearms in Gambella
A Soviet Union General-Purpose Machine Gun (PKM) and more than 300,000 South Sudanese pounds impounded from smugglers in Gambella | Photo: EBC
The Ethiopian government has arrested five suspects accused of illegally smuggling more than 300,000 South Sudanese pounds, PKM machine guns and rounds of ammunition in Gambella, a town bordering Ethiopia and South Sudan.
According to Ethiopian Broadcasting Corporation, "the five suspects were arrested while smuggling foreign money and weapons from neighboring South Sudan."
The incident was also confirmed by Gambella's Deputy Police Commissioner, Tut Khor. "The five suspects were arrested three days ago in the Gambella region, and are in police custody before they are brought before the court as soon as their investigation is finalized."
More than 300,000 South Sudanese pounds impounded from South Sudan's nationals | Photo: ETB
South Sudan and Ethiopia have porous border points that make it easy for criminal groups to smuggle firearms and illicit money used to fund illegal activities in the region.
Last week, the two neighboring countries inked an agreement aimed at curbing cross-border criminals activities in the region.
The cooperation agreement was signed by the Ethiopian Chief of General Staff, General Birhanu Jula and his South Sudanese counterpart Gen. Johnson Juma Okot in the Ethiopian capital, Addis Ababa.