New ways of providing affordable home occupation are being sought which enable low and middle income groups to get onto the housing ladder, while avoiding some of the risks associated with full ownership. One such means is shared ownership; a product that allows a home buyer to purchase a proportion of the equity in a home, thereby paying a mortgage on part of the property, and a subsidised rent on the remainder. This PhD thesis explores the conditions that led to the emergence of shared ownership products in the UK housing sector and considers the costs and benefits of such schemes to tenants and social enterprises (e.g. housing associations) that operate them.
Rowena has gained extensive knowledge on contemporary debates in housing and particular expertise in the issue around shared ownership. This knowledge is both theoretical, informed by a comprehensive review of the academic literature, and practical, informed by the good relationship and close involvement of the CASE partner.
The supervisory team have built a strong relationship with the CASE partner which holds promise for further collaborations and on-going outputs from the project. The supervisors consider that the empirical study from this studentship is very strong and will produce future high quality academic publications jointly with Rowena. The supervisors additionally benefit in expanding their expertise through the in-depth knowledge the studentship is generating on shared ownership in the housing sector.
The partner has gained a valuable extensive and comprehensive literature overview of the latest academic reflections and theorisations on the housing sector. The partner closely defined the research topic and is very pleased with the progress of the studentship; as such the CASE partner gains outputs from a detailed and in-depth research project directly on a topic of high priority for their own knowledge and development.


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Chris Blakemore
"I am a retired Accountant and Company Director and became a Trustee of Heartcare in 2001 because I was impressed by the work that it does helping patients to recover who have suffered cardiac problems".
"I am a member of The Rotary Club of Aldridge which has supported Heartcare over the years". "I have always been impressed by the effort the Heart Care team put in and after suffering a bypass operation in 2009, I experienced first hand the hard work put into my recovery".
Eric Watts
"I qualified as an Accountant, Company Secretary in 1956 and spent the early part of my early career in Finance where I became a Director in 1959, I had formed my own Company by 1962 Watts Clift Holdings Ltd". "I held various Director roles at Watts Clift Holdings during my career and became Chairman in 1983 and I am still active in this role today".
"I formed Walsall Heart Care Cardiac Trust with Dr Ron McKechnie 1980 and started a Walsall Fun Run with the Aldridge Rotary in 1981 and raised £9000 in the first year". "This continued for 8 years until we could appoint a part time Fund raiser". "We raised monies for the purchase of the properties and borrowed the balance from the Bank".
"I trained as a State Registered Nurse in the early 1980s and I worked for the NHS for 37 years most of this was spent in cardiac nursing. The latter half of my career encompassed a number of managerial and commissioning roles before retiring in 2016".
"I have a keen interest in cardiac rehabilitation and during my career had close links with a number of cardiac rehabilitation services across the Birmingham and the Black Country". "I worked for Walsall Manor Hospital for a number of years and referred many patients to Heart Care so appreciated the positive benefits of the rehabilitation service". "This made it an easy decision, to serve as a Trustee and didn't hesitate to take on this role".
"I remain committed to helping Heart Care deliver help and support to local patients and hope we can continue, in alliance with the NHS and community to deliver this service for many years to come".
Angie Haire
"While a Walsall GP for 31 years my patients found Heartcare an inspiring place for rehabilitation for Heart and Lung Disease". "With the help of the dedicated and friendly staff they gain the motivation and confidence to move to a healthy lifestyle through exercise, counselling and healthy eating"
"'As a trustee I hope to help Heartcare develop it's services in health and well being for all the people of Walsall"
Phil Griffin
I am a recently retired NHS senior manager with considerable commissioning, project management and contracting experience . I have always wanted to use this experience to the benefit of the voluntary sector so I was delighted I was able to join the Heart Care Trustees about 18 months ago.
I have particular expertise in working with NHS clinicians including consultants, GPs, specialist heart nurses, cardiac technicians and patients. My work involved improving the coronary care pathway in Walsall including rehabilitation services using nationally developed cardiac standards. I am also able to support contract review processes with our local commissioner and undertake a range of Governance oversight responsibilities expected of a Trustee including financial review and risk management .
I truly believe that cardiac rehabilitation is a very important part of the heart pathway and as a Trustee I will work to ensure that the services we have developed as a Charity over many years continue to be available to people that need them now and in the future.

redpajama_set_name: RedPajamaCommonCrawl


Black patent dress shoes for your Bitty Baby boy dolls. Perfect for a Christmas or Easter outfit.
Cute yellow canvas sneakers in bright yellow for your Bitty baby dolls. Great for Bitty twins too!
White canvas sneakers for your Bitty Baby dolls including the Bitty Twins.
Light blue kroc duck shoes for your Bitty Baby dolls.


Last month, we had the pleasure to support Texas Linux Fest. One thing that makes Linux festivals special is simply witnessing the importance of community. Interacting with individuals that share a similar passion with you sparks a special feeling that you really can't replicate. At Texas Linux Fest, we could definitely feel this in the open source air, especially when we brought out Linux Trivia!
So sure, the internet connects us with millions of beautiful people from around the globe but it just doesn't feel the same as sitting down with your friends to share a toast, laugh in unison, or just to have the sense of togetherness.
Finding friends in your immediate area to share the love for Linux and the Open Source community can seem scarce. It can even be impossible at times. Let's face it, your local pub probably doesn't host a weekly Linux-themed trivia night. (If you do, that's awesome and we'd love for you to comment below with your meetup to help others find it!). But if not, why not host one yourself? We'll even help you get started!
For all this and more, we've prepared a Linux Trivia powerpoint for you to use. Help spread the open source and Linux love around in your community. Whether you're creating this new community or finding them, be sure to embrace it and celebrate that bond. After all, we all learn from each other, right?
Create new friendships, share some laughs, learn some Linux tips & commands, and interact with each other through a friendly competition.
Don't forget to let us know how the event goes, cheers to open source & community!
Looking to learn Linux? Spin up your own personal cloud servers and start mastering the command line today!
Which of the following was the first feature major motion picture produced entirely on Linux servers?
Which language is the primary language that the Linux kernel and its modules were (and still are) written in?
You want to locate all known commands that are associated with a key word. Which of the following commands would you use with that key word?


DocuTAP, one of the nation's fastest growing healthcare technology companies and provider of electronic medical records (EMR) and practice management (PM) software for urgent care clinics, is pleased to announce the appointments of Ronald Curtis as SVP of Product and Kerri Tietgen as EVP of People and Culture.
Curtis and Tietgen have joined the rapidly growing company and robust executive team within the last quarter and will play critical roles as DocuTAP continues to help clinics effectively navigate the expanding on-demand healthcare space.
Curtis has more than 20 years of experience building and leading product organizations and joins DocuTAP's executive team as SVP of Product to drive market opportunities and product initiatives. Prior to DocuTAP, Curtis served as VP Product Management at Cardlytics where he was responsible for identifying and assessing market opportunities and helped create the company's Product organization.
An experienced consultant and team developer, Tietgen has worked with organizations of all sizes throughout her career. As EVP of People and Culture, Kerri also sits on the executive team and is focused on leadership development. Before joining DocuTAP, she ran her own consulting firm for over 10 years where she focused on organizational development, executive coaching, and the development of people and teams.
Like the on-demand healthcare space, DocuTAP continues to evolve. Adding top-tier talent to its leadership team will shape the trajectory of the company's growth—and its success.
Posted in DocuTAP News on November 20, 2018.


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German police raid mosque and apartments in crackdown on Salafists
Editor's note: LUBP has been consistently advocating similar action against the radical Deobandis in Pakistan. The radical Deobandis hold very similar and dangerous views as the radical Salafis elsewhere in the world. The Salafi/Wahhabi and Deobandi connection which goes back to over a century. the founders and progenitors of the Deobandi sect and Abdul Wahab are said to have the same teacher, Mohammad Hayat Al-Sindhi.
BERLIN: German police have searched a mosque and eight apartments in Hildesheim that are believed to be a hotbed of a radical Salafist community, the interior minister of the northern state of Lower Saxony said on Thursday.
Germany is on high alert after a spate of attacks since July 18 left 15 people dead – including four attackers – and dozens injured. Two assailants, a Syrian asylum seeker and a refugee from either Pakistan or Afghanistan, had links to militancy, officials say.
Interior Minister Boris Pistorius said in a statement that up to 400 police – including mobile squads and a special forces police commando – were involved in the raids on Wednesday in the Hildesheim area, which is a short drive south of Hanover.
"The German-speaking Islamic circle (DIK) in Hildesheim is a nationwide hot-spot of the radical Salafist scene that Lower Saxony security authorities have been monitoring for a long time," the state official said.
Pistorius said the search followed months of planning and was an important step toward banning the association, which security authorities say has radicalised Muslims and encouraged them to take part in jihad in combat zones.
Numerous members of the mosque have traveled to Syria and Iraq to join Islamic State, while sermons, seminars and speeches call for "hate against non-believers," the ministry said.
Germany has seen sharp increases in the number of ultra-conservative Muslims known as Salafists in recent years, with the total number of sympathizers now seen at 8,900, up from 7,000 at the end of 2014, German officials have said.
Security authorities say the DIK in Hildesheim is believed to have become the focal point of Salafist activities in Lower Saxony, the second-largest of Germany's 16 states after Bavaria.
"We will not put up with Salafist associations and their backers flouting our rules and bringing our rule of law into question and convincing young people that they want to join the so-called IS," Pistorius said.
"I'm convinced that our freedom is stronger than the inhuman ideology of the extremists," he added.
http://tribune.com.pk/story/1151149/german-police-raid-mosque-apartments-crackdown-salafists/
TagsAl-Qaeda Anjem Choudary Germany Great Britain or United Kingdom UK ISIS Daesh ISIL Saudi Arabia KSA Syria & Syrian Civil War Takfiri Deobandis & Wahhabi Salafis & Khawarij Taliban & TTP Terrorism
A Threat to American Heritage – by Muhammad Faisal Younus
Security forces seal deobandi seminary, arrest 100 Afghan Students in Quetta


Notes: This is my first CustomFit sweater. We are going to be offering CustomFit services (measuring, classes, knitalong) at the shop this fall so we're all making sweaters to try it out. I chose one of the "classic" designs. All the options (3/4 length sleeve, low-hip length, band width, etc.) were all pre-selected. Unfortunately my sleeve length measurements were wrong so this came out more bracelet length. The shaping is perfect. I have princess seams in the front for bust shaping as well as shaping up the back. It just fits so nicely. I made everyone at Purlygirls stop knitting so they could admire my new sweater. I love it!
It was pretty dark when these photos were taken. The sweater is a much brighter yellow-y green.


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Chargers' Joe Lombardi eager to build an…
Chargers' Joe Lombardi eager to build an offense around Justin Herbert
The new offensive coordinator said he's learned from his prior stint as the Lions' play caller in 2014-15
Joe Lombardi, right, works with New Orleans Saints quarterback Drew Brees with offensive coordinator Pete Carmichael, left, last summer. (AP Photo/Gerald Herbert, pool)
By Gilbert Manzano | gmanzano@scng.com |
Brandon Staley observed from the back of the room while Joe Lombardi instructed the New Orleans Saints' quarterbacks, including Drew Brees.
Nearly 12 years before Staley asked Lombardi to be his offensive coordinator with the Chargers, Lombardi invited his former quarterback turned coach to a training camp visit as the Saints embarked on their Super Bowl season of 2009.
"I'd bet you that he's watched every single game we've played on offense here in New Orleans since then," Lombardi said Tuesday about Staley, who at the time coached defensive linemen and special teams at St. Thomas, a Division III program in Minnesota. "Just (Staley's) familiarity with me and what we've done here (in New Orleans), it makes it such an easier transition."
If Lombardi's guess about the recently-hired Chargers head coach is true, then Staley has watched more than 160 Saints games from the past decade.
On Monday, Staley hired Lombardi as the Chargers' new offensive coordinator. Lombardi spent 12 seasons on Sean Payton's coaching staff during two stints in New Orleans — 10 overall as the quarterbacks coach, including the past five seasons.
Lombardi, 49, said he had interest in other coaching jobs since the Detroit Lions fired him as the offensive coordinator in 2015, but he wasn't going to jump at any opportunity. It needed to make sense and familiarity was important to him.
Staley, 38, was Lombardi's quarterback for one season at Mercyhurst University in 2005, when Lombardi was the offensive coordinator.
"Brandon, No. 1," Lombardi said when asked why the Chargers' opening was the right fit. "How well I know him and I think how well he knows me. … Not to mean that we're going to copy (the Saints' offense), but just coming from a common background of football, to be able to get things started. As he is in the beginning of putting a staff together, what he is looking for, it all lines up with the way that I think.
"Sean Payton often says that he is more interested in compatibility first before he thinks about capability. I just think that the compatibility of what Brandon is building here is going to be second-to-none."
Lombardi will likely incorporate some parts of the Saints' offense to form the right scheme for quarterback Justin Herbert and the rest of the Chargers' offense, but he knows the importance of flexibility.
Lombardi said a reason why his stint with the Lions didn't work out was because he forced the Saints' offensive system instead of using it as a starting point to build off players' strengths.
The Lions finished 11-5 during Lombardi's first season in 2014, but the offense based on short passes, timing and precision produced mixed results for quarterback Matthew Stafford and a Lions team that ranked 19th in total offense. It got worse the following season and the Lions fired Lombardi after a 1-6 start.
"The biggest thing is just being able to be more flexible," Lombardi said about what he learned the most as a first-time play caller in Detroit. "Spending so much time in New Orleans and doing things one way, you kind of get used to that. When you're put into a new situation where the schedule is different, and maybe you're around coaches that weren't used to doing things the way that you were used to, just having flexibility to adjust a little bit better maybe than we did back then.
"That's the biggest thing, just the flexibility to adjust when things aren't the way that you're used to them being."
Staley has only coached in the NFL for four seasons, but he's had plenty of success by prioritizing players' strengths over schemes. Lombardi said he is eager to form an offensive coaching staff with Staley.
Lombardi wants coaches from other offensive schemes to provide different perspectives, which will be vital for Herbert's development after a dynamic rookie season.
"He's got a skill set that's elite," Lombardi said about Herbert. "It appears there's nothing that he can't do. He's got an incredibly strong arm, good accuracy and he's very athletic. Sounds like he's a real smart guy that's a good leader. He just checks all the boxes."
Lombardi said it's too soon to reveal what the Chargers' offense will look like in 2021, but he said Staley wants tempo.
With Herbert's downfield accuracy, and Staley looking to play off his quarterbacks' strengths, Lombardi will likely call many deep shots, but he understands what type of weapons Herbert has.
Wide receiver Keenan Allen, running back Austin Ekeler and tight end Hunter Henry thrive with up-tempo passes, a staple of the Saints' offense since Payton took over in 2006. The Chargers' trio had a similar style with quarterback Philip Rivers before Herbert took over in 2020.
Allen had an instant connection with Herbert, but Henry and Ekeler, one of the best pass-catching running backs in the NFL, often got lost when the rookie quarterback was looking upfield for wide receivers Mike Williams, Jalen Guyton and Tyron Johnson.
It will be up to Lombardi and Staley to find the right balance to utilize all of the Chargers' skill players.
Lombardi has shown he's able to evolve around his Saints quarterbacks in recent years. He's worked with quick passers Brees and Teddy Bridgewater, aggressive quarterback Jameis Winston and athletic quarterback Taysom Hill.
Watching how Payton changed the Saints' offense from Brees as the focal point to wide receiver Michael Thomas and running back Alvin Kamara as the centerpieces, will likely help Lombardi in his second opportunity as an offensive coordinator.
Chargers interview New York Giants' Thomas McGaughey for special teams
Chargers fire special teams coordinator Derius Swinton II after one season
Brandon Staley, Chargers to prioritize defense in offseason
Alexander: Chargers' aggressive play-calling here to stay
Chargers' offseason outlook: Pending free agents and biggest needs
Lombardi said it's important to have a balanced offense, which scared some Chargers fans on social media, but he reiterated the importance of using Herbert's strengths as a passer.
"I think it's important to have some balance," Lombardi said. "But when you have a quarterback as talented as Justin, you want to let him throw the ball when it's appropriate. That's for sure."
Herbert had a historic rookie season under prior head coach Anthony Lynn, but the coaching staff was often criticized for conservative play calling and not taking enough chances on fourth down.
Lombardi wasn't as cautious in his response when asked about possibly going for it more on fourth downs.
"I'm a big fan of going for it on fourth down," Lombardi said. "I know all the data analysis says that we are probably not aggressive enough as NFL coaches. I'm in favor of moving in that direction."
Gilbert Manzano | Reporter
Gilbert Manzano grew up reading the Pasadena Star-News, and now he's the Chargers beat writer for the Southern California News Group. Manzano moved back to Pasadena after working three years for the Las Vegas Review-Journal as a Raiders and boxing reporter. The Cal State Northridge graduate spent two seasons as a breaking news editor for NFL.com. The Spanish-speaking lefty likes to go on runs with his dog, Cam.
gmanzano@scng.com
Follow Gilbert Manzano	@GManzano24
More in Los Angeles Chargers


Situated 5 km from Resorts World Manila in Manila, Skylab213B has free WiFi access. The property has a common lounge area and a shared kitchen with kitchen ware. Every room has a shared bathroom. Guests can find restaurants, banks and shops in the surrounding area. Spa treatments can be arranged upon request at extra charges. The inn also offers car hire. City of Dreams Manila is 8.5 km from Skylab213B, while SM Mall of Asia Arena is 9 km away. The nearest airport is Manila International Airport, 4.2 km from Skylab213B.
Please inform Skylab213B in advance of your expected arrival time. You can use the Special Requests box when booking, or contact the property directly with the contact details provided in your confirmation.


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Portland • Hotels
The Hoxton Portland
The Hoxton's habit of integrating local life into the travel experience continues in Oregon, as Portland joins their expanding roster...
Lisa Davidson • 18 December, 2018
With 119 rooms to bed down in, expansive communal spaces, and a choice of three restaurants—including the all-day rooftop eatery with views across the city—The Hoxton, Portland, is the second American outpost for the Ennismore-created brand; following a theme for seeking style with its location in the hip city's offbeat Old Town Chinatown neighbourhood.
Housed within a building that dates back to 1906, rooms are spread across Shoebox, Snug, Cosy, and Roomy categories, and—as is The Hoxton way—have been designed to make the most of the space without compromising on comfort. Rich walnut panelling is the backdrop for contemporary artworks, ceramics, and bookshelves all of which have been curated by local business owners, artists, residents, and artisans.
Referred to warmly as Hox Friends, these insights into Portland life feature alongside perks that devotees of The Hox have grown accustomed to, such as a mini fridge for you to stock at your whim with fairly-priced goodies from the reception shop, and a daily 'emergency' breakfast bag delivered straight to your door.
Serving as boltholes for travellers and local alike since 2006 when their first 'open house' hotel opened in Shoreditch, The Hoxton have established a reputation for vibrant public spaces and on-trend food offerings—Portland being no different with a large open lobby to relax, work, and play; a basement bar serving inventive cocktails focussed around rice- based spirits; all-day dining destination, La Neta, serving Mexican-influenced fare on the ground floor; and Tope, the rooftop taqueria boasting views across the city.
Throw in a stellar calendar of cultural and lifestyle events, a retail collection of products created in collaboration with local brands to showcase the best of the neighbourhood, and a Portland iteration for The Apartment—the hotel brand's multi-functional events and meetings space—The Hoxton have arrived in Oregon with all the aplomb, style, and substance we've come to expect.
@TheHoxtonHotel
Photography, courtesy The Hoxton Portland
Bars, Interiors, Food & Drink, Hotels, Portland, Design, The Hoxton
There's no rock and roll, but plenty of art and creativity at London's alt-souvenir store We Built This City...
Ghent office block takeover WATT reveals a whole new way of looking at the pretty Belgian city...
Technology welcomes new dawn: we experience Audi's piloted driving concept setting records on the track...
Portlanders get a slice of the action, as Vancouver's Virtuous Pie arrives Stateside in serious style...
Following on from the rapid success of their first Vancouver restaurant, the guys behind Virtuous Pie — an eatery on a mission to accelerate the adoption of the plant-based diet — have stepped onto American soil for the first time. Portland,...
Serious coffee with smiley aesthetics, Portland's NEVER is a juxtaposition that hits all the right notes...
NEVER COFFEE Portland, serves up some of the city's finest third wave coffee in a small but perfectly-executed space on Belmont Street. A neighbourhood joint where bumping elbows and standing to enjoy a quick espresso is actively encouraged,...
Welcome Home: Portland's The Society Hotel honours authentic experiences free from attitude and pretension...
Located in the longtime-vacant Mariners Building in the heart of downtown Portland, The Society Hotel is a project from Matt Siegel, Jonathan Cohen, Gabe Genauer and Jesse Burke; combining lodging solutions and affordable prices in a lovingly...
Chef and bartender come together at Franco-Belgian passion project La Moule, Portland...
There are few greater joys in life than a big bowl of mussels accompanied by a plate of frites and a Belgian beer. La Moule in Portland, Oregon, is attempting to prove that there are: an expertly-crafted cocktail for afters. (Or...


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Q: VM restoring issue My VM has apparently crashed, probably due to a virus attack. Here's the message I'm getting
The saved memory file "/Users/fjacks/Desktop/Windows Vista.vmwarevm/Windows Vista.vmem" is corrupt and cannot be restored.
What are my options? This has never happened before. Please, no lectures about windows and viruses. I need a solution, not another problem.
!file:///Users/fjacks/Library/Caches/TemporaryItems/moz-screenshot.png!!file:///Users/fjacks/Library/Caches/TemporaryItems/moz-screenshot-1.png!

A: The .vmem file is a copy of the running memory state on the VM and is only present when a VM is running or has crashed. You should be able to restart the machine if the .vmem is corrupt but you wont be able to restore it to the running state. To get around this rename the relevant file to something else (to get past the corruption issue) and try to power on the VM.
When you say "probably due to a virus attack" was this on the guest system or the host? Whichever it was you should seriously consider cleanly rebuilding it and sanitizing all data - anything on the infected system is now highly suspect.

redpajama_set_name: RedPajamaStackExchange


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Beijing Downplays Reports Taiwan Defense Minister May Visit US - 2002-02-26
China appears to be downplaying reports the United States may allow a top official from Taiwan to visit. In the past, Beijing has reacted angrily on such matters. Beijing's first comment on the reports was unusually mild.
Chinese Foreign Ministry spokesman Kong Quan says China resolutely opposes official ties between the United States and Taiwan, especially in the military field. "He is referring to news reports that Washington may give a visa to Taiwan's Defense Minister, Tang Yao-ming so he can attend a military conference in the U.S. state of Florida next month."
Taiwan broke away from China amid civil war in 1949, and has been ruled separately ever since. Beijing says Taiwan is part of China and has worked hard for decades to isolate the prosperous, democratic island diplomatically.
Beijing opposes any diplomatic links or actions that imply Taiwan is a separate nation from China. Beijing has reacted furiously in the past when Washington granted top Taiwanese officials visas for even the briefest visits to the United States.
This new case is sensitive because the Florida meetings involve major U.S. military contractors and arms suppliers. Under U.S. law, Washington can sell Taiwan enough weapons to defend itself from its huge rival on the mainland. But Beijing has been pushing Washington to reduce arms sales to Taiwan.
The U.S. State Department has not confirmed the reports that a visa will be granted to Taiwan's defense minister.
The controversy follows months of effort by China to improve relations with the United States, which is a major trading partner and investor for China. Last week, President Bush visited China for talks that yielded no major agreements, but which were seen by both sides as warm and successful.


On Wednesday 17th June PF Whitehead's Transport Manager, Matt Allen, joined the RHA and a group of industry professionals to deliver a petition to No 10 Downing Street.
The petition details the driver shortage crisis and the knock on effects this has on the UK logistics supply chain and urges the Prime Minister to address the threat in the July budget.
Read more in the Freight Industry Times article and hear what RHA Chief Executive, Richard Burnett, had to say on BBC Breakfast.


Signs of Child Abuse - Do you need help?
HomeChildren & Young PeopleDo you need help?
We have created a great new video animation to show how we can help you and get you the support you need.
Click here to find out what to do if you call 999 in an emergency but you are unable to talk.
extra support. It means you get the right people offering the right support at the right time. This Early Help Leaflet can help explain this in a bit more detail for you.


You are being informed that IBPS i.e. Institute of Banking Personnel Selection has released the Result for the IBPS Clerk Mains Exam. The candidates those who appeared in this exam can check their result through the below mentioned link. The IBPS Clerk 2018- 19 Mains Exam was held on 20 January 2019. Candidates who are selected after the final round are handed the appointment letter to join the Bank of their choice.


BATON ROUGE, La. — Global technology leader IBM will conduct a career fair on Saturday, April 6, in Baton Rouge to fill openings for experienced and emerging information technology professionals at its flagship Client Innovation Center in downtown Baton Rouge. The 10 a.m. to 2 p.m. career fair will take place at Baton Rouge Community College's Bienvenue Student Center, located at 201 Community College Drive.
LED FastStart®, the nation's top-ranked state workforce development program, is supporting the event. Interviews will take place on-site for all interested candidates, and attendees are asked to dress professionally and bring their résumés.
To access the Bienvenue Student Center at BRCC's Mid City Campus, take Exit 158 on Interstate 10 and travel north on College Drive, then turn left on Foster Drive. Continue on Foster across Government Street and turn right onto the Baton Rouge Community College campus. The Bienvenue Student Center will be on the left. Signage will be available to direct participants to the building.
IBM is seeking to fill more than 50 available positions in Baton Rouge. To see the list of available jobs, visit IBMLouisiana.com/jobs. Candidates may register for the career fair and also upload résumés at that website. IBM officials will be on hand at the career fair to screen and interview applicants.


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Popular Pairings
Literature Directory
Near Hentai
Nearphotison's Hentai
Character Asks Hunter × Hunter
Gon and Killua Character Ask 1
By Nearphotison on Tuesday, July 31, 2018
I was looking over this question and, you know, I figured… Why not? When I watched Hunter × Hunter I thought the way they raised money seemed a little suspect. Like, the story was presented in a way where it didn't seem impossible that they could raise money the way they did, but I like the idea of this explanation for how they rounded the numbers out enough to get to where they needed to be. At the very least it's super in-character for the versions of the characters I present in my content.
Colorization Comic Dragon Ball Traveling to Planet Namek
ben_10mil – Traveling to Planet Namek 03
By Nearphotison on Monday, July 30, 2018
Here's the new page of ben_10mil's comic Traveling to Planet Namek with inks, colors and translation by yours truly. In this page Gohan and Krillin are enjoying their bath together, but a little accidental contact reveals Krillin's packing a surprise!
As always, here's the original page for comparison's sake:
Commission The Boondocks
Ruckus' Pleasure Holes, Pt. 2
By Nearphotison on Sunday, July 29, 2018
Here's the second and final part of the "Ruckus' Pleasure Holes" commission series. After finishing up with the back ends of Riley and Huey, the anonymous dudes found their way around the wall (probably what the boys should have done, but luckily for us they tried to fit through these holes instead). Finding the top halves of the boys, the strangers decide to clean off the cocks they just wrecked their asses with.
Colorization Comic S wa Fragile no S
Takatsu – S wa Fragile no S, Page 06
By Nearphotison on Saturday, July 28, 2018
I don't know if I'll be able to maintain this pace forever, but I am trying to get these early pages of Takatsu's S wa Fragile no S colored relatively quickly since it's a much longer and slower-paced comic than the ones I usually color. If it updated at the same page as the other comics I color, it'd probably be next year before we even got to see a dick or anything. So here, enjoy this new page where we see Satou-kun bullying poor Suzuki-kun after school.
Applebridge Applebridge Bios
Mace Mezzenga Bio
By Nearphotison on Friday, July 27, 2018
I've been thinking about doing something like this for a while, and a couple different times people have asked me to do bio pages for the Applebridge characters. The main reason I haven't before now is just that I don't really know how to, but… Well, here goes. This is Mace's bio page, and hopefully I'll get around to making ones for all the Applebridge characters eventually. 🙂
Asta Character Ask 1
By Nearphotison on Thursday, July 26, 2018
So in Hunter × Hunter, Asta and Killua start off bickering, but eventually they seem to find an understanding, which is what this Ask is referring to. In the show they seemed to just realize that they both had things to contribute to their group, but that's a little boring by Near Hentai standards so instead Asta answers…. about like how you'd expect my version of her would. >_>
Takatsu – S wa Fragile no S, Pages 01-05
By Nearphotison on Wednesday, July 25, 2018
Okay, so, this one's been simmering for a long time. I feel like it was probably a year or two ago I saw the first chapter of this manga floating around on e-hentai and immediately fell in love with it. It's one of my favorite original character doujins, for reasons I can't entirely pinpoint. It's just a great combination of character design quirks that speak to my personal tastes as well as a unique story and character dynamic that all comes together spectacularly for me, personally. I love it so much that at one point I was toying with doing an Applebridge comic based on a similar premise, but in the end I decided instead that I would just color this. Now, this is a huge comic (as anyone who's seen it or is willing to look up the original could tell you), at well over a hundred pages. I don't plan to color some of the filler chapters that don't pertain to the main plot, but even cutting those it's still over a hundred pages easily. So this will be a long-haul project. I'm sorry to anyone who is already frustrated with how many projects I balance, but some itches need to be scratched or they'll drive you insane.
GeGeGe no Kitarō
Yūta-kun
I've been watching the latest version of GeGeGe no Kitarō, an old horror anime for kids that gets remade about once every ten years. The newest version is more like a shounen adventure anime than the usual ones, but I like it and have a lot of ideas for it. The show has one minor character that I instantly fell in love with, and that's Yūta-kun. He's a pretty insignificant part of the show, though he does have one episode so far dedicated to him. He's the shy and delicate neighbor of Mana, who's the new protagonist that befriends Kitarō, and the second I saw him I knew I had to draw him. I wanna draw him again, too, maybe where he's being sweet and cute instead of getting wrecked like this. I drew him nude at first, but I decided to add his sweater vest because it's really cute.
Applebridge Character Asks
Loren Cox Character Ask 2
I was super happy to see Loren get not one, but two Character Asks the first month after his debut! Since he seems so popular, I'll definitely have to think of more excuses to draw him in the future. As for his answer here, Loren's got a real thing for studly men who can pin him down and fuck him senseless, so Goku is a natural fit out of the characters in the Near Hentai Studios. However, he's hear rumors about Luffy, who's also a bit of a newcomer to the studio, which is of course the person he refers to but doesn't know by name.
Disney The Incredibles
Elastic Tongue
So I have about five or six half-finished Incredibles pictures lying around in my work folder (I have more unfinished pics than I can count), and all the buzz around the Incredibles sequel got me itching to draw Helen again. I resisted that urge and instead wrapped up this pic, which I started a couple months ago. I just like how much pleasure Violet seems to be in here. It's kind've up to your imagination how Helen's using her tongue back there, but given her elastic stretching powers there's lots of possibilities.
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PhonoApps are computational and learning tools for phonologists.
PhonoApps are supported by the University of Toronto Advancing Teaching and Learning in Arts and Science (ATLAS) grant to Peter Jurgec. First released in August 2018.


text:
Joseph Bibby
ARTICLE UNDER CONSTRUCTION
Joseph Bibby (1851–1940) was an English industrialist and member of the Theosophical Society based in Adyar, Chennai, India He is best known as the editor of Bibby's Annual.
1 Family life
3 Theosophic Society involvement
4 Publication of Bibby's Annual
Clara Codd wrote of the Bibby family:
He lived in a beautiful house and grounds near Birkenhead; and all his eight children, six boys and two girls, lived with him. I never met a happier family. They never quarreled and when the sons married, they built another house near their father's Two of his sons were killed in the first world war and another was badly wounded... Mrs. Bibby was a frail, sweet little lady of Quaker extraction... she started life with him in a working-man's cottage.
Often have I stayed at the Bibby's home. The first time I went there, the youngest boy and girl met me at the train. I noticed they were convulsed with giggles. At home Mrs. Bibby said to me: "You won't mind, but the children were so funny. I asked them if they found you easily, and they said, 'Oh! Yes Mama, there was such a strong smell of fish about.'"[1]
Mr. Bibby's manufacturing business produced soap and animal feed, such as oil cakes for cattle.[2]
Theosophic Society involvement
Joseph Bibby became a member of the Theosophical Society in Liverpool on January 23, 1889.[3]
Bibby met young Clara Codd, when she began touring England as a lecturer in 1906. She became a frequent visitor to the Bibby home. He proposed to send Clara for a two-year course at the Theosophical Society headquarters in Adyar, Madras, India, and financed the trip.
Publication of Bibby's Annual
Of this enterprise, Clara Codd wrote,
His great delight was the editing of his famous Bibby's Annual. Many will remember its outstanding articles and its gloriously reproduced pictures. The articles were his way of helping the Theosophical Society, though he also gave large sums of money, too. Sometimes I would go with him to picture galleries of all kinds to find pictures to reproduce in his magazine. Because he would accept no advertisements, he lost, so he told me, a regular £1,000 a year on his journal. But he willingly lost it because of the good it did. It had a circulation all over the world of about one million. As far away as New Zealand did I discover Bibby's Annual."[4]
In 1922, publication came to an end.
Theosophists the world about will learn with deep regret that Bibby's Annual for 1922 announces the discontinuance of that beautiful periodical. To learn that this masterpiece of artistic printing is to cease publication is much like hearing that a dear friend has passed on. For many years Bibby's Annual has carried the gospel of Theosophy into multiplied thousands of homes in all parts of the world. Its reading matter was edited with the same care that was given to the art subjects from which its wealth of pictures was drawn. "Perfection" is a word that should be used with caution, but it may safely be said of Bibby's Annual that very few things in any realm of human effort have come so near to the goal of perfection.[5]
↑ Clara Codd, So Rich a Life (Pretoria: Institute for Theosophical Publicity, 1956), 103-104.
↑ T. A. B. Corley, "Bibby, Joseph (1851–1940)", Oxford Dictionary of National Biography. 2004. Available online by subscription at this website.
↑ Theosophical Society General Membership Register, 1875-1942 at http://tsmembers.org/. See book 1, entry 4831 (website file: 1b/50).
↑ Anonymous, "Bibby's Annual Discontinue" The Messenger 9.12 (May, 1922), 266.
Retrieved from "https://theosophy.wiki/w-en/index.php?title=Joseph_Bibby&oldid=35642"
TS Adyar


text:
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Within the music industry, a mechanical license gives the holder permission to create copies of a recorded song or musical composition, a sound recording, which they did not write and/or do not have Copyright over. It is a music contract Agreement with the Copyright holder, the publisher, or the songwriter that allows the holder to reproduce the sound recording.
A mechanical license is not generally required for an artist who is recording and distributing her/his/their own work. This is also used by recording artists performing cover versions of songs and artists who do not typically write their own songs, as is typical in Country and Top 40 music.
This is a five page, fifteen clause legal music contract Agreement.
We regularly receive feedback that we have successfully drafted our music contracts to be as complete as possible for all legal situations. However, should you experience a unique personal situation requiring the drafting of a special clause, please contact us at your convenience. Otherwise, you may be obliged to find a local entertainment lawyer experienced in the music industry who will draft any and all other clauses for your Project's unique situation or circumstance.
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Mechanical License (Royalties)
Owner Name: _____________________________________________________ (Print Names) Area of Entertainment: ______________________________________________ Licensee Company: _______________________________________________ Licensee Company Representative: __________________________________ Project: _________________________________________________________ (records, cassettes, CDs, DVDs, Internet Downloads, etc.) Herein this Agreement is between the above named and below signed Owner of the musical composition(s) (herein called the "Owner") and the above named and below signed purchaser of distribution Rights (herein called the "Licensee"). The Licensee is a going concern that specializes in the recording reproducing, marketing and selling musical compositions. The term "phonorecord(s)" or "records", as used herein, means any and all methods of mechanically reproducing a musical Composition including, but not limited to the following: phonograph records, cassette tapes, digital audio tape, compact disc, Internet Download and any and all methods of reproducing a Composition, now known or in the future to come into existence. HENCE, in consideration of the promises, and of the mutual undertakings herein contained, and for other good and valuable considerations, the above named and below signed Owner and the above named and below signed Licensee agree as follows: 1. The Owner hereby grants to the Licensee the Right to record, reproduce, market and sell the musical composition(s) listed in Appendix "A" under each composition's current title, including composer's names (herein called the "Composition") 2. The Owner warrants and represents that she/he/it is the sole and exclusive proprietor of a valid Copyright or License in …continued 10. Commencing with the signing of this Agreement and continuing for the term of this Agreement, the Licensee will diligently use her/his/its best efforts to secure distribution of the Recording throughout . . . continued
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text:
#ifndef CAPU_IPHONEOS_TCPSERVERSOCKET_H
#define CAPU_IPHONEOS_TCPSERVERSOCKET_H

#include <capu/os/MacOSX/TcpServerSocket.h>

namespace capu
{
    namespace iphoneos
    {
        class TcpServerSocket: private capu::os::TcpServerSocket
        {
        public:
            using capu::os::TcpServerSocket::accept;
            using capu::os::TcpServerSocket::close;
            using capu::os::TcpServerSocket::bind;
            using capu::os::TcpServerSocket::listen;
            using capu::os::TcpServerSocket::port;
            using capu::os::TcpServerSocket::getSocketDescription;
        };
    }
}
#endif // CAPU_IPHONEOS_TCPSERVERSOCKET_H

redpajama_set_name: RedPajamaGithub


A 25-year-old Texan just landed a six-figure book deal for her wildly popular fan-fic starring Harry Styles and the boy band. What's next?
Fan fic, in which amateurs write and share unauthorized adventures featuring established characters or real people, has been big business for many years. "Fifty Shades of Grey" started as "Twilight" fan fic. But this is the first big deal to involve a "Directioner," as members of the massive 1D fan-fic community call themselves. (Other big musical subjects of RPF - real people fiction - include Beyonce and 5 Seconds of Summer).
"After" imagines a bad-boy punk version of Styles falling for sheltered college freshman Tessa, whose world is upended by their relationship. Todd put the story up in daily installments - some 300 short chapters spread out across three volumes - on the relatively new Wattpad, where it was an almost instant hit. Wattpad's Ashleigh Gardner says that even before Todd finished the first volume, "After" was registering all over the company's internal social media metrics, with fan-generated art and custom musical playlists popping up on Twitter and Instagram. When Todd mentioned "Pride and Prejudice" or "Wuthering Heights" in "After," Wattpad had spikes in the reads (how the company counts clicks) on those novels on its site.
To date, "After" has notched more than 800 million reads and ended 2013 as the site's most-shared story. Wattpad reached out to Todd, helped her build her fan base during the next two volumes and guided her toward a book deal, essentially acting as her agent.
Beginning in November, Gallery Books will publish a reworked version of "After" that will turn Styles into a fully fictionalized character in the way that "Twilight" characters Bella and Edward were reworked into Anastasia and Christian when "Fifty Shades of Grey" went from fan fic to traditional book. If Todd is even a tiny bit as successful as E.L. James, who has sold more than 70 million copies of "Fifty Shades of Grey," she'll be writing new verses of that fairytale song long into the future.


text:
Indications : Asthma
Pregnancy Category B
FDA Approved 2003 Jun
DRUG CLASS : : Monoclonal antibodies
BRAND NAMES : Xolair (US);
For Subcutaneous Use
Xolair is a recombinant DNA-derived humanized IgG1? monoclonal antibody that selectively binds to human immunoglobulin E (IgE). The antibody has a molecular weight of approximately 149 kilodaltons. Xolair is produced by a Chinese hamster ovary cell suspension culture in a nutrient medium containing the antibiotic gentamicin. Gentamicin is not detectable in the final product.
Xolair is a sterile, white, preservative-free, lyophilized powder contained in a single-use vial that is reconstituted with sterile water for injection (SWFI), and administered as a subcutaneous (SC) injection. A Xolair vial contains 202.5 mg of omalizumab, 145.5 mg sucrose, 2.8 mg L-histidine hydrochloride monohydrate, 1.8 mg L-histidine, and 0.5 mg polysorbate 20, and is designed to deliver 150 mg of omalizumab in 1.2 ml after reconstitution with 1.4 ml SWFI.
Omalizumab inhibits the binding of IgE to the high-affinity IgE receptor (FceRI) on the surface of mast cells and basophils. Reduction in surface-bound IgE on FceRI-bearing cells limits the degree of release of mediators of the allergic response. Treatment with omalizumab also reduces the number of FceRI receptors on basophils in atopic patients.
After SC administration, omalizumab is absorbed with an average absolute bioavailability of 62%. Following a single SC dose in adult and adolescent patients with asthma, omalizumab was absorbed slowly, reaching peak serum concentrations after an average of 7-8 days. The pharmacokinetics of omalizumab are linear at doses greater than 0.5 mg/kg. Following multiple doses of omalizumab, areas under the serum concentration-time curve from Day 0 to Day 14 at steady-state were up to 6-fold of those after the first dose.
In vitro, omalizumab forms complexes of limited size with IgE. Precipitating complexes and complexes larger than 1 million daltons in molecular weight are not observed in vitro or in vivo . Tissue distribution studies in cynomolgus monkeys showed no specific uptake of 125I-omalizumab by any organ or tissue. The apparent volume of distribution in patients following SC administration was 78 ± 32 ml/kg.
Clearance of omalizumab involves IgG clearance processes as well as clearance via specific binding and complex formation with its target ligand, IgE. Liver elimination of IgG includes degradation in the liver reticuloendothelial system (RES) and endothelial cells. Intact IgG is also excreted in bile. In studies with mice and monkeys, omalizumab:IgE complexes were eliminated by interactions with Fc? receptors within the RES at rates that were generally faster than IgG clearance. In asthma patients omalizumab serum elimination half-life averaged 26 days, with apparent clearance averaging 2.4 ± 1.1 ml/kg/day. In addition, doubling body weight approximately doubled apparent clearance.
In clinical studies, serum free IgE levels were reduced in a dose dependent manner within 1 hour following the first dose and maintained between doses. Mean serum free IgE decrease was greater than 96% using recommended doses. Serum total IgE levels (i.e., bound and unbound) increased after the first dose due to the formation of omalizumab:IgE complexes, which have a slower elimination rate compared with free IgE. At 16 weeks after the first dose, average serum total IgE levels were 5-fold higher compared with pre-treatment when using standard assays. After discontinuation of omalizumab dosing, the omalizumab-induced increase in total IgE and decrease in free IgE were reversible, with no observed rebound in IgE levels after drug washout. Total IgE levels did not return to pre-treatment levels for up to 1 year after discontinuation of omalizumab.
The population pharmacokinetics of omalizumab were analyzed to evaluate the effects of demographic characteristics. Analyses of these limited data suggest that no dose adjustments are necessary for age (12-76 years), race, ethnicity, or gender.
The safety and efficacy of omalizumab were evaluated in three randomized, double-blind, placebo-controlled, multicenter trials.
The trials enrolled patients 12-76 years old, with moderate to severe persistent (NHLBI criteria) asthma for at least 1 year, and a positive skin test reaction to a perennial aeroallergen. At screening, patients in Studies 1 and 2 had a forced expiratory volume in 1 second (FEV1) between 40 and 80% predicted, while in Study 3 there was no restriction on screening FEV1. All patients had a FEV1 improvement of at least 12% following beta-agonist administration. All patients were symptomatic and were being treated with inhaled corticosteroids (ICS) and short acting beta-agonists. In Study 3, long-acting beta-agonists were allowed. Study 3 patients were receiving at least 1000 µg/day fluticasone propionate and a subset was also receiving oral corticosteroids. Patients receiving other concomitant controller medications were excluded, and initiation of additional controller medications while on study was prohibited. Patients currently smoking were excluded.
Each study was comprised of a run-in period to achieve a stable conversion to a common ICS (beclomethasone dipropionate, for Studies 1 and 2; fluticasone propionate for Study 3), followed by randomization to omalizumab or placebo. In Study 3, patients were stratified by use of ICS-only or ICS with concomitant use of oral steroids. Patients received omalizumab for 16 weeks with an unchanged corticosteroid dose unless an acute exacerbation necessitated an increase. Patients then entered an ICS reduction phase of 12 weeks (Studies 1 and 2) or 16 weeks (Study 3) during which ICS (or oral steroid in Study 3 subset) dose reduction was attempted in a step-wise manner.
Omalizumab dosing was based on body weight and baseline serum total IgE concentration. All patients were required to have a baseline IgE between 30 and 700 IU/ml and body weight not more than 150 kg. Patients were treated according to a dosing table to administer at least 0.016 mg/kg/IU (IgE/ml) of omalizumab or a matching volume of placebo over each 4 week period. The maximum omalizumab dose per 4 weeks was 750 mg; patients who had a weight-IgE combination that yielded a dose greater than 750 mg were excluded from the studies. Patients who were to receive more than 300 mg within the 4 week period were administered half the total dose every 2 weeks.
The distribution of the number of asthma exacerbations per patient in each group during a study was analyzed separately for the stable steroid and steroid-reduction periods. In all three studies an exacerbation was defined as a worsening of asthma that required treatment with systemic corticosteroids or a doubling of the baseline ICS dose.
In both Studies 1 and 2 the number of exacerbations per patient was reduced in patients treated with omalizumab compared with placebo (TABLE 1). In Study 3 the number of exacerbations in patients treated with omalizumab was similar to that in placebo-treated patients (TABLE 2). The absence of an observed treatment effect in Study 3 may be related to differences in the patient population compared with Studies 1 and 2, study sample size, or other factors. In all three studies most exacerbations were managed in the out-patient setting and the majority were treated with systemic steroids. Hospitalization rates were not significantly different between omalizumab and placebo-treated patients; however, the overall hospitalization rate was small. Among those patients who experienced an exacerbation, the distribution of exacerbation severity was similar between treatment groups.
TABLE 1 Frequency of Asthma Exacerbations per Patient by Phase in Studies 1 and 2
Exacerbations per Patient
Stable Steroid Phase (16 Weeks)
p-Value
Mean number exacerbations/patients
Steroid Reduction Phase (12 Weeks)
Mean number exacerbations/patient
TABLE 2 Percentage of Patients with Asthma Exacerbations by Subgroup and Phase in Study 3
Inhaled Only
Oral + Inhaled
Patients with =1 exacerbations
Difference (95% CI)
0.9 (-9.7, 13.7)
9.8 (-10.5, 31.4)
-4.4 (-17.6, 7.4)
-0.2 (-22.4, 20.1)
In all three of the studies, a reduction of asthma exacerbations was not observed in the omalizumab-treated patients who had FEV1 > 80% at the time of randomization. Reductions in exacerbations were not seen in patients who required oral steroids as maintenance therapy.
In Studies 1 and 2 measures of airflow (FEV1) and asthma symptoms were evaluated (TABLE 3). The clinical relevance of the treatment-associated differences is unknown.
TABLE 3 Asthma Symptoms and Pulmonary Function During Stable Steroid Phase of Study 1
n=268*
Mean Baseline
Median Change (Baseline to Week 16)
Ttoal asthma symptom score
-1.5†
Nocturnal asthma score
Daytime asthma score
FEV1% predicted
3†
Asthma symptom scale: total score from 0 (least) to 9 (most); nocturnal and daytime scores from 0 (least) to 4 (most symptoms).
* Number of patients available for analysis ranges 255-258 in the omalizumab group and 238-239 in the placebo group.
† Comparison of omalizumab versus placebo (p <0.05).
Results from the stable steroid phase of Study 2 and the steroid reduction phases of both Studies 1 and 2 were similar to those presented in TABLE 3.
Omalizumab is indicated for adults and adolescents (12 years of age and above) with moderate to severe persistent asthma who have a positive skin test or in vitro reactivity to a perennial aeroallergen and whose symptoms are inadequately controlled with inhaled corticosteroids. Omalizumab has been shown to decrease the incidence of asthma exacerbations in these patients. Safety and efficacy have not been established in other allergic conditions.
CONTRAINDICATIONS :
Omalizumab should not be administered to patients who have experienced a severe hypersensitivity reaction to omalizumab (see WARNINGS, Anaphylaxis).
Malignant neoplasms were observed in 20 of 4127 (0.5%) omalizumab-treated patients compared with 5 of 2236 (0.2%) control patients in clinical studies of asthma and other allergic disorders. The observed malignancies in omalizumab-treated patients were a variety of types, with breast, non-melanoma skin, prostate, melanoma, and parotid occurring more than once, and five other types occurring once each. The majority of patients were observed for less than 1 year. The impact of longer exposure to omalizumab or use in patients at higher risk for malignancy (e.g., elderly, current smokers) is not known (see ADVERSE REACTIONS).
Anaphylaxis has occurred within 2 hours of the first or subsequent administration of omalizumab in 3 (<0.1%) patients without other identifiable allergic triggers. These events included urticaria and throat and/or tongue edema (see ADVERSE REACTIONS). Patients should be observed after injection of omalizumab, and medications for the treatment of severe hypersensitivity reactions including anaphylaxis should be available. If a severe hypersensitivity reaction to omalizumab occurs, therapy should be discontinued (see CONTRAINDICATIONS).
Omalizumab has not been shown to alleviate asthma exacerbations acutely and should not be used for the treatment of acute bronchospasm or status asthmaticus.
Corticosteroid Reduction
Systemic or inhaled corticosteroids should not be abruptly discontinued upon initiation of omalizumab therapy. Decreases in corticosteroids should be performed under the direct supervision of a physician and may need to be performed gradually.
Patients receiving omalizumab should be told not to decrease the dose of, or stop taking any other asthma medications unless otherwise instructed by their physician. Patients should be told that they may not see immediate improvement in their asthma after beginning omalizumab therapy.
Serum total IgE levels increase following administration of omalizumab due to formation of omalizumab:IgE complexes (see CLINICAL PHARMACOLOGY and DOSAGE AND ADMINISTRATION). Elevated serum total IgE levels may persist for up to 1 year following discontinuation of omalizumab. Serum total IgE levels obtained less than 1 year following discontinuation may not reflect steady-state free IgE levels and should not be used to reassess the dosing regimen.
No long-term studies have been performed in animals to evaluate the carcinogenic potential of omalizumab.
No evidence of mutagenic activity was observed in Ames tests using six different strains of bacteria with and without metabolic activation at omalizumab concentrations up to 5000 µg/ml.
The effects of omalizumab on male and female fertility have been assessed in cynomolgus monkey studies. Administration of omalizumab at doses up to and including 75 mg/kg/week did not elicit reproductive toxicity in male cynomolgus monkeys and did not inhibit reproductive capability, including implantation, in female cynomolgus monkeys. These doses provide a 2- to 16-fold safety factor based on total dose and 2- to 5-fold safety factor based on AUC over the range of adult clinical doses.
Reproduction studies in cynomolgus monkeys have been conducted with omalizumab. Subcutaneous doses up to 75 mg/kg (12-fold the maximum clinical dose) of omalizumab did not elicit maternal toxicity, embryotoxicity, or teratogenicity when administered throughout organogenesis and did not elicit adverse effects on fetal or neonatal growth when administered throughout late gestation, delivery, and nursing.
IgG molecules are known to cross the placental barrier. There are no adequate and well-controlled studies of omalizumab in pregnant women. Because animal reproduction studies are not always predictive of human response, omalizumab should be used during pregnancy only if clearly needed.
The excretion of omalizumab in milk was evaluated in female cynomolgus monkeys receiving SC doses of 75 mg/kg/week. Neonatal plasma levels of omalizumab after in utero exposure and 28 days of nursing were between 11% and 94% of the maternal plasma level. Milk levels of omalizumab were 1.5% of maternal blood concentration. While omalizumab presence in human milk has not been studied, IgG is excreted in human milk and therefore it is expected that omalizumab will be present in human milk. The potential for omalizumab absorption or harm to the infant are unknown; caution should be exercised when administering omalizumab to a nursing woman.
Safety and effectiveness in pediatric patients below the age of 12 have not been established.
In clinical trials 134 patients 65 years of age or older were treated with omalizumab. Although there were no apparent age-related differences observed in these studies, the number of patients aged 65 and over is not sufficient to determine whether they respond differently from younger patients.
No formal drug interaction studies have been performed with omalizumab. The concomitant use of omalizumab and allergen immunotherapy has not been evaluated.
The most serious adverse reactions occurring in clinical studies with omalizumab are malignancies and anaphylaxis (see WARNINGS). The observed incidence of malignancy among omalizumab-treated patients (0.5%) was numerically higher than among patients in control groups (0.2%). Anaphylactic reactions were rare but temporally associated with omalizumab administration.
The adverse reactions most commonly observed among patients treated with omalizumab included injection site reaction (45%), viral infections (23%), upper respiratory tract infection (20%), sinusitis (16%), headache (15%), and pharyngitis (11%). These events were observed at similar rates in omalizumab-treated patients and control patients. These were also the most frequently reported adverse reactions resulting in clinical intervention (e.g., discontinuation of omalizumab, or the need for concomitant medication to treat an adverse reaction).
Because clinical trials are conducted under widely varying conditions, adverse reaction rates observed in the clinical trials of one drug cannot be directly compared with rates in the clinical trials of another drug and may not reflect the rates observed in medical practice.
The data described above reflect omalizumab exposure for 2076 adult and adolescent patients ages 12 and older, including 1687 patients exposed for 6 months and 555 exposed for 1 year or more, in either placebo-controlled or other controlled asthma studies. The mean age of patients receiving omalizumab was 42 years, with 134 patients 65 years of age or older; 60% were women, and 85% Caucasian. Patients received omalizumab 150-375 mg every 2 or 4 weeks or, for patients assigned to control groups, standard therapy with or without a placebo.
TABLE 4 shows adverse events that occurred =1% more frequently in patients receiving omalizumab than in those receiving placebo in the placebo-controlled asthma studies. Adverse events were classified using preferred terms from the International Medical Nomenclature (IMN) dictionary. Injection site reactions were recorded separately from the reporting of other adverse events and are described following TABLE 4.
TABLE 4 Adverse Events =1% More Frequent in Omalizumab-Treated Patients
Skin and Appendages
Dermaititis
Age (among patients under age 65), race, and gender did not appear to affect the between group differences in the rates of adverse events.
Injection Site Reactions
Injection site reactions of any severity occurred at a rate of 45% in omalizumab-treated patients compared with 43% in placebo-treated patients. The types of injection site reactions included: bruising, redness, warmth, burning, stinging, itching, hive formation, pain, indurations, mass, and inflammation.
Severe injection-site reactions occurred more frequently in omalizumab-treated patients compared with patients in the placebo group (12% vs 9%).
The majority of injection site reactions occurred within 1 hour-post injection, lasted less than 8 days, and generally decreased in frequency at subsequent dosing visits.
Immunogenicity
Low titers of antibodies to omalizumab were detected in approximately 1/1723 (<0.1%) of patients treated with omalizumab. The data reflect the percentage of patients whose test results were considered positive for antibodies to omalizumab in an ELISA assay and are highly dependent on the sensitivity and specificity of the assay. Additionally, the observed incidence of antibody positivity in the assay may be influenced by several factors including sample handling, timing of sample collection, concomitant medications, and underlying disease. Therefore, comparison of the incidence of antibodies to omalizumab with the incidence of antibodies to other products may be misleading.
Allergic symptoms, including urticaria, dermatitis, and pruritus were observed in patients treated with omalizumab. There were also 3 cases of anaphylaxis observed within 2 hours of omalizumab administration in which there were no other identifiable allergic triggers (see WARNINGS, Anaphylaxis).
The maximum tolerated dose of omalizumab has not been determined. Single IV doses of up to 4000 mg have been administered to patients without evidence of dose-limiting toxicities. The highest cumulative dose administered to patients was 44,000 mg over a 20 week period, which was not associated with toxicities.
Omalizumab 150-375 mg is administered SC every 2 or 4 weeks. Because the solution is slightly viscous, the injection may take 5-10 seconds to administer. Doses (mg) and dosing frequency are determined by serum total IgE level (IU/ml), measured before the start of treatment, and body weight (kg). See the dose determination charts below (TABLE 5 and TABLE 6) for appropriate dose assignment. Doses of more than 150 mg are divided among more than 1 injection site to limit injections to not more than 150 mg per site.
TABLE 5 ADMINISTRATION EVERY 4 WEEKS: Omalizumab Doses (mg) Administered by SC Injection Every 4 Weeks for Adults and Adolescents (12 Years of Age and Older) With Asthma
Body Weight (kg)
Pre-Treatment Serum IgE (IU/ml)
>60 to 70
>90 to 150
=30-100
>100-200
* See TABLE 6.
TABLE 6 ADMINISTRATION EVERY 2 WEEKS: Omalizumab Doses (mg) Administered by Subcutaneous Injection Every 2 Weeks for Adults and Adolescents (12 Years of Age and Older) With Asthma
Pre-Treatement Serum IgE (IU/ml)
† DO NOT USE.
Dose Adjustment
Total IgE levels are elevated during treatment and remain elevated for up to 1 year after the discontinuation of treatment. Therefore, re-testing of IgE levels during omalizumab treatment cannot be used as a guide for dose determination. Dose determination after treatment interruptions lasting less than 1 year should be based on serum IgE levels obtained at the initial dose determination. Total serum IgE levels may be re-tested for dose determination if treatment with omalizumab has been interrupted for 1 year or more.
Doses should be adjusted for significant changes in body weight. (See TABLE 5 and TABLE 6.)
Stability and Storage
Omalizumab should be shipped at controlled ambient temperature [=30°C (=86°F)]. Omalizumab should be stored under refrigerated conditions 2-8°C (36-46°F). Do not use beyond the expiration date stamped on carton.
Omalizumab is for single-use only and contains no preservatives. The solution may be used for SC administration within 8 hours following reconstitution when stored in the vial at 2-8°C (36-46°F), or within 4 hours of reconstitution when stored at room temperature.
Reconstituted omalizumab vials should be protected from direct sunlight.
Xolair is supplied as a lyophilized, sterile powder in a single-use, 5 cc vial that is designed to deliver 150 mg of omalizumab upon reconstitution with 1.4 ml SWFI.


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One of the most vital skills in entrepreneurship is the ability to push outside of your comfort zone and keep learning. Whether it's a new technology changing your industry or a novel approach to marketing, it's important to keep your eyes open, take in these changes, and allow them to inform your offerings and your business.
It's even better if you can absorb these ideas and teach your peers about them – positioning you as a thought leader in your industry, even while you're still learning and growing alongside everybody else. We also touched on this idea in the previous episode with Michael Roderick.
Sometimes, it's best to educate people who are just a few steps behind you in business, rather than those who are just starting out. You can teach others as you're learning, stay ahead of the curve in your industry, and build a dedicated community around your ideas and knowledge.
Natalie Sisson has been practicing this approach by educating fellow entrepreneurs since she started her business ten years ago as a suitcase entrepreneur.
She's been on a quest to discover what freedom really means for almost a decade.
After 8 years in the corporate world, and two years as co-founder of a tech company, she turned her blog The Suitcase Entrepreneur into an online education company where she created online courses, coached, taught workshops, and held international retreats to show people how to build a business they loved, from anywhere. She did all this while living out of a suitcase for 6.5 years and traveling to 70 countries.
Then in 2016 she moved home to New Zealand to live a more rooted lifestyle and pivot in her business. Now, she does strategic consulting with impact-driven ventures, coaches purpose-driven entrepreneurs, and builds online learning solutions to help people thrive in the future of work.
Natalie has had such a fascinating career and is a true lover of learning. We talk about how she grew The Suitcase Entrepreneur while traveling the world and helping other business owners create more lifestyle freedom through their work.
Natalie also highlights the importance of continual learning and why positioning yourself as a "leading learner" is often more dynamic and fulfilling than claiming to be a "guru" or "expert".
We also talk about how she transitioned her business as her life became more settled, how she navigated re-branding herself and her work, and why she didn't want to scale everything up. And, we discuss the fascinating future of work and how technology is becoming more integrated with what we do – and how to prepare for the changes that are already on their way.
How Natalie built a thriving online business around her desire for freedom and travel.
Why she prefers the term "leading learner" to titles like expert or guru.
How Natalie transitioned her business and scaled things back so she could establish a more rooted lifestyle after moving back to New Zealand.
Why it can be more effective to educate people only a few steps behind you rather than complete beginners.
How Natalie used the tools she uses with clients to redesign her business and get excited about entrepreneurship all over again.
What the future of work looks like and why the special skills humans have will only become more important.
What Mastery means to Natalie:
Fully comprehending a concept and being able to teach & apply it with real insight.
Turning point:
When I designed my business around my lifestyle and created more time, money and freedom as a result.
Natalie's Core message:
That we have so much more potential than we often realize and it's up to us to unleash it.
Links mentioned in this show
Natalie Sisson | Instagram | Twitter | LifePilot | Natalie's Books
Roger Hamilton – Wealth Dynamics
Thrive Architect for WordPress
Trint – AI-powered transcription
Ready to position your brand, grow your business, and increase your freedom? Sign up for the next round of my two-day Position Your Mastery workshop, happening August 1st & 2nd!


This article describes the general content and distribution requirements of the summary plan description under the Employee Retirement Income Security Act (ERISA).
content and distribution requirements of the summary plan description.
What is Covered in the Summary Plan Description?
When Must a Summary Plan Description be Provided?
Inc.Are There Any Exceptions to the Summary Plan Description? Employer-provided daycare and welfare plans for management and highly compensated employees are exempt from the SPD requirement. long term disability benefits. by Mark Johnson provides benefit consulting and advisory services and does not engage in the practice of law. J. 2010 .D.erisa-benefits. pension benefits in bankruptcy. How Often Must a Summary Plan Description be Updated? If a plan is amended or modified within a five year period. forfeitures. ESOP and pension fiduciary liability. About the Author. October. is a highly experienced ERISA expert. A "summary of material modifications" may also be used to notify plan participants of a significant plan change. As a former ERISA Plan Managing Director and plan fiduciary for a Fortune 500 company..com. third party administrator disputes. ERISA Benefits Consulting. What Are Common SPD Errors that Can Result in ERISA Litigation? Administration errors or disputes that may result in ERISA litigation include but are not limited to:  Failure to follow the procedures described in the SPD  Conflicts between the SPD and any underlying plan document which it describes or summarizes  Failure to clearly disclose circumstances that may result in benefits reduction. the original SPD must be distributed to plan participants every ten years. ERISA provides clearly proscribed procedures that must be closely followed by plan sponsors and administrators. or exclusions  Failure to provide plan documents in a timely manner Overall. Johnson has practical knowledge of plan documents as well as an in-depth understanding of ERISA obligations. individual benefit claims. There are no exemptions from the SPD requirement for small plans covering fewer than 100 participants. Mark Johnson. Ph. a new SPD must be distributed to participants. and cash conversion balances. If there is no change.. He can be reached at 817-909-0778 or www.D. Dr. retiree medical benefit coverage. Questions about ERISA compliance should be directed to an attorney experienced in ERISA matters. He works as an expert consultant and witness on 401(k).


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Q: Dependency property default value does not show in properties browser I have a custom window class that inherits from window class. In custom class I defined a dependency property and set its default value. But the default value does not show in property browser panel of visual studio. How can I fix this problem
Best regards.
namespace WpfApplication2
{
    [Description("Some descriptions")]
    public class FlatWindow:Window
    {
        public FlatWindow()
        {
            if(DesignerProperties.GetIsInDesignMode(this))
            {
                this.HasCloseButton = true;
            }
        }

        [Description("my description"), Category("my Properties"), Browsable(true),DefaultValue(true)]
        public bool HasCloseButton
        {
            get { return (bool)GetValue(HasCloseButtonProperty); }
            set { SetValue(HasCloseButtonProperty, value); }
        }

        // Using a DependencyProperty as the backing store for MyProperty.  This enables animation, styling, binding, etc...
        public static readonly DependencyProperty HasCloseButtonProperty =
            DependencyProperty.Register("HasCloseButton", typeof(bool), typeof(FlatWindow),new FrameworkPropertyMetadata(true,FrameworkPropertyMetadataOptions.AffectsRender));
}
}

Screen shot from VS

A: Dependency Property (DP) appear in Visual Studio property browser when you use :

*

*Custom control

*Control

*UserControl

Unfortunately the properties box now show DP when you use "Window"
You can see on msdn more on Dependency Property


Have you ever wondered what it would feel like to get eloped in the mountains right next to your close family members? Well, I've got a treat for you. Last summer I had an amazing privilege to photograph this gorgeous couple tying the knot at Stanley Lake, Idaho. These two are one powerful couple, Danette is an amazing makeup artist and Andy on the other hand is a badass helicopter pilot. First thing Danette told me when we first met is that she wanted a calm small wedding in the middle of Idaho. I was so excited to hear this, it was a nice change of pace at the time with so many large weddings we had. It felt great just to be in the moment and photograph this gorgeous couple. Andy and Danette got ready at their rustic cabin near Redfish Lake, just 1 hour away from Sun Valley. For their first look, they both wanted the legendary Sawtooth mountains in the background. Right after they saw each other, their family joined them right on the waters edge of Stanley Lake. After a tear jerking vowels, these two said their " I Do's" and off they went on their honeymoon to the Caribbean Islands. If you aren't big into large weddings, I highly recommend just having a small and intimate elopement at a place that means the most to both of you.