Joaquin Mateo, M.D., Suzanne Carreira, Ph.D., Shahneen Sandhu, M.D., Susana Miranda, B.Sc., Helen Mossop, M.Math.Stat., Raquel Perez-Lopez, M.D., Daniel Nava Rodrigues, M.D., Dan Robinson, Ph.D., Aurelius Omlin, M.D., Nina Tunariu, M.D.Res., Gunther Boysen, Ph.D., Nuria Porta, Ph.D., Penny Flohr, B.Sc., Alexa Gillman, B.Sc., Ines Figueiredo, B.Sc., Claire Paulding, B.Sc., George Seed, M.Sc., Suneil Jain, M.D., Christy Ralph, M.D., Andrew Protheroe, M.D., Ph.D., Syed Hussain, M.D., Robert Jones, M.D., Ph.D., Tony Elliott, M.D., Ph.D., Ursula McGovern, M.D., Ph.D., Diletta Bianchini, M.D., Jane Goodall, B.Sc., Zafeiris Zafeiriou, M.D., Chris T. Williamson, Ph.D., Roberta Ferraldeschi, M.D., Ph.D., Ruth Riisnaes, F.I.B.M.S., Bernardette Ebbs, B.T.E.C., Gemma Fowler, B.Sc., Desamparados Roda, M.D., Wei Yuan, Ph.D., Yi-Mi Wu, Ph.D., Xuhong Cao, M.S., Rachel Brough, Ph.D., Helen Pemberton, Ph.D., Roger A'Hern, Ph.D., Amanda Swain, Ph.D., Lakshmi P. Kunju, M.D., Rosalind Eeles, M.D., Ph.D., Gerhardt Attard, M.D., Ph.D., Christopher J. Lord, Ph.D., Alan Ashworth, Ph.D., Mark A. Rubin, M.D., Karen E. Knudsen, Ph.D., Felix Y. Feng, M.D., Ph.D., Arul M. Chinnaiyan, M.D., Ph.D., Emma Hall, Ph.D., and Johann S. de Bono, M.B., Ch.B., Ph.D.
Prostate cancer is a heterogeneous disease, but current treatments are not based on molecular stratification. We hypothesized that metastatic, castration-resistant prostate cancers with DNA-repair defects would respond to poly(adenosine diphosphate [ADP]–ribose) polymerase (PARP) inhibition with olaparib.
We conducted a phase 2 trial in which patients with metastatic, castration-resistant prostate cancer were treated with olaparib tablets at a dose of 400 mg twice a day. The primary end point was the response rate, defined either as an objective response according to Response Evaluation Criteria in Solid Tumors, version 1.1, or as a reduction of at least 50% in the prostate-specific antigen level or a confirmed reduction in the circulating tumor-cell count from 5 or more cells per 7.5 ml of blood to less than 5 cells per 7.5 ml. Targeted next-generation sequencing, exome and transcriptome analysis, and digital polymerase-chain-reaction testing were performed on samples from mandated tumor biopsies.
Overall, 50 patients were enrolled; all had received prior treatment with docetaxel, 49 (98%) had received abiraterone or enzalutamide, and 29 (58%) had received cabazitaxel. Sixteen of 49 patients who could be evaluated had a response (33%; 95% confidence interval, 20 to 48), with 12 patients receiving the study treatment for more than 6 months. Next-generation sequencing identified homozygous deletions, deleterious mutations, or both in DNA-repair genes — including BRCA1/2, ATM, Fanconi's anemia genes, and CHEK2 — in 16 of 49 patients who could be evaluated (33%). Of these 16 patients, 14 (88%) had a response to olaparib, including all 7 patients with BRCA2 loss (4 with biallelic somatic loss, and 3 with germline mutations) and 4 of 5 with ATM aberrations. The specificity of the biomarker suite was 94%. Anemia (in 10 of the 50 patients [20%]) and fatigue (in 6 [12%]) were the most common grade 3 or 4 adverse events, findings that are consistent with previous studies of olaparib.


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Folli Follie is one other multi-brand Bologna store, a destination for fashion lovers of all ages. However there are also little boutiques in Bologna which are just as fascinating. These embody Jacqueline – which is exactly forty metres square and is just like the closet of your goals – Dondup, Golden Goose Kristina Ti, Jo No Fui, Fuel By Marie, and Mister & Mrs Fur. There's a careful collection of brands, one which corresponds to a selected fashion – for the trendy, glamorous lady who loves timeless magnificence. In Via Indipendenza, between the signs of the commercial chains, there's a mirage: a shop signal that hasn't modified since 1835.
That is complete trendsetting, from the furnishings and the make-up to the perfumes and the jewelry, with a ground put aside specifically for music. It contrasts with the brand new Borgo delle Tovaglie, a flagship being opened right this moment: the five hundred sq. metres inside were once a furrier's workshop they usually retain the interval ambiance. Between tough walls and industrial buildings, a dreamy, poetic wonderland opens up. Working with the Milan-primarily based Orlandi house, the philosophy is to let fashion, design and artwork mix together. Some individuals are saying that it is a space destined to change town.
Located simply south of Central Park are the ladies's and men's shops of Bergdorf Goodman ( ), on opposite sides of Fifth Avenue at 754 and 745 Fifth Avenue respectively. The quintessential luxury New York shopping expertise, going robust since 1899, they carry a variety of high-end clothes and have signature design houses resembling Chanel, Gucci, Versace and, for the boys, Yves Saint Laurent and Paul Smith. The women's retailer is the show-stopper. Chic, modern brands similar to 3.1 Philip Lim, Alexander Wang and Theyskens' Idea might be discovered in the 5F Contemporary section catering to young, refined Gossip Women. For an afternoon break, head to the seventh flooring the place BG Restaurant serves a full lunch menu and high tea.
All of us love the thought of finding that secret designer cut price or vintage clothing in a charity shop, but relating to it, hunting them down in all these racks is usually a bit confusing, and more often that not we end up leaving empty-handed. Keep in mind the Vogue District is 100 blocks, so put on snug footwear. This excellent purchasing app for that look that you simply will not discover in any mall.


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V Wine Room, V Cheese Shoppe, and I have teamed up to bring you an incredibly scrumptious tasting event. Featuring #VeganCheese and Decadent Desserts paired with Vegan Wines and Live Jazz.
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Zoodles are noodles made out of zucchini, nothing more. Using a julienne peeler or spiralizer, the zucchini is cut into noodles. Whenever I make zoodles, I usually dress them in a pesto or top them with marinara. This pesto has a lovely mix of basil, kale, and spinach, and because this recipe was is Fall- and Halloween-inspired, pumpkin seeds were thrown into the mix. The end result is really delicious.
After tossing the zoodles with pumpkin kale pesto, throw in some sliced grape tomatoes for more texture and sweetness. When served with my Pink Peppercorn vegan "Goat Cheese," it is even more satiating and scrumptious.
For a quick, raw, and satisfying meal, try this dish. You will be happy you did!
1. Make zoodles using a julienne peeler or a spiralizer. When using a julienne peeler, carefully peel the zucchini as you would a carrot, making long "noodles". When using a spiralizer to make zoodles, follow the manufacturer's directions.
1. Place all of the Pumpkin Kale Pesto ingredients into a food processor or blender, and pulse until fully pureed and sauce-like in consistency.
1. Carve faces in your peppers. To do this, cut a round section on the top of the pepper. Discard the seeds and scrape away the insides. Being very careful, begin to carve the jack-o'-lantern face. When complete, set aside.
a) place onto a plate. Add about 8 grape tomato halves to the zoodles, and if you have it, a slice of Pink Peppercorn Vegan "Goat Cheese". Serve immediately.
b) Toss in the sliced tomatoes and stuff each bell pepper with zoodles and tomatoes, replacing the top of the pepper once filled.
I absolutely love Thanksgiving stuffing. For as long as I can remember, my family enjoyed Stove Top stuffing for the holidays. For my first holiday season as a vegan, my holiday meals didn't feel complete without my beloved stuffing. Thankfully, I discovered raw vegan stuffing through Kimberly Snyder, my health and nutrition guru. I adapted her recipe by changing up and adding a few other herbs and spices. I also made my version lower in fat by reducing the amount of oil and adding a vegetable stock (ok, that's not fully raw) or filtered water (this is raw!) instead!
After reading the Food Babe's article highlighting what toxins may be hiding in typical American Thanksgiving feasts, I was thoroughly disgusted. I actually don't miss Stove Top stuffing one bit! Why would I subject my body (and the bodies of my loved ones) to toxic food when I can make non-gmo, nutrient-dense, better-for-you versions myself? And they're so easy to make, too!
I am so happy that I can now enjoy my raw stuffing and share it with everyone! This recipe isn't just for the holiday season, it can be enjoyed year-round as a side dish, added to a salad, or stuffed into lettuce wraps!
One bite of this stuffing and you will be in disbelief at how much this tastes just like Stove Top stuffing! It truly is amazing how good this is!!
My friend, Jasmine, and I created a bountiful Thanksgiving feast for our readers to enjoy, which consists of 13 deliciously tantalizing recipes! We're referring to this collection of recipes as our Sweet Eclectic Thanksgiving celebration! We hope you include this recipe, as well as our other recipes, on your holiday tables!
and hashtag #SweetEclecticThanksgiving #MyEclecticKitchen if you recreate any of our recipes! We would love to see your photos and Thanksgiving feasts!
1. Process the soaked almonds and pecans in the food processor until they are chunky and not too fine.
2. Pour the nuts into a large bowl, then add the remaining ingredients, and mix well.
3. Cover and refrigerate until serving.
I made tabouli for the first time a couple of weeks ago using Kimberly Snyder's recipe from her book "Beauty Detox Solution", and I really liked it! It's so fresh, tangy and delicious!
My husband (my best test-taster) though, didn't love the slightly peppery and almost anise-like taste of the parsley. Since it's been warm out, I thought a fresh Mediterranean salad would be perfect to start tonight's dinner. This time, though, I would only use half of the parsley I used last time and I'd add in kale to make up for the other half of parsley in the recipe. I'd also add cayenne for a little kick.
Without having told Peyman I changed up the salad, he told me, "I like the tabouli better today than the last time you made it". My eyes lit up and I explained to him why. Yay! Hooray! This tabouli is husband-approved. Success!
1. Chop parsley and kale (Will be quick if you use a food processor to chop the greens) and place in a large bowl with the onion, tomato and hemp seeds.
2. In a blender, combine lemon, garlic, olive oil and salt and blend until smooth.
3. Pour dressing over the salad and mix well. It's best chilled.


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California Gov. Newsom Signs Bill Protecting Wild Animals from Super-Toxic Rat Poisons
California Leads the Nation on Safeguards for Second-Generation Anticoagulant Rodenticides
Sacramento, CA (September 29, 2020) — Gov. Gavin Newsom signed the California Ecosystems Protection Act (AB 1788) into law today, placing greater restrictions — with limited exceptions — on the use of second-generation anticoagulant rodenticides to protect the state's native wildlife.
The bill, introduced by Assemblymember Richard Bloom (D-Santa Monica), requires state regulators to reduce the threats to nontarget wildlife before the restrictions on second-generation anticoagulant rodenticides can be lifted.
Raptors Are the Solution
A project of Earth Island Institute
"Anticoagulants are wiping out the very wildlife that help control rodents naturally. There is a groundswell of support for this bill, which takes a giant step to reduce secondary poisoning," said Lisa Owens Viani, director of Raptors Are The Solution, a project of Earth Island Institute.
"We can protect public health without threatening California's wildlife," said Jonathan Evans, environmental health legal director at the Center for Biological Diversity. "We applaud Governor Newsom and Assemblymember Bloom for their leadership in protecting California's mountain lions, bobcats, and kit foxes."
Rodents that consume these long-lasting poisons are in turn consumed by other wildlife, resulting in secondary poisoning and contamination of the food chain. Developed in the 1970s, second-generation anticoagulant rodenticides have higher potency than earlier compounds. A single dose has a half-life of more than 100 days in a rat's liver.
"These 'one-feeding-kills' poisons are devastating California's wild animals, including some of the state's most beloved species like mountain lions," said Stephen Wells, executive director of the Animal Legal Defense Fund. "California has taken a critical step towards safeguarding these animals from unnecessary suffering and death."
Despite a 2014 ban on consumer sales, rodenticides continue to be heavily used by commercial operators. The California Department of Pesticide Regulation's 2018 analysis of 11 wildlife studies determined anticoagulant rodenticides are poisoning a wide range of animals, including mountain lions, bobcats, hawks, and endangered wildlife such as Pacific fishers, spotted owls, and San Joaquin kit foxes.
There are many safer alternatives to anticoagulant rodenticides. Exclusion and sanitation are the best approach to managing rodents. Sealing buildings, eliminating food and water sources, and trimming foliage and tree limbs from the sides and roofs of houses are also important steps to reduce the presence of rodents. When physical exclusion is not possible, there are dozens of safer rodent control options, including providing owl boxes in rural areas to encourage natural predation, and using traps that don't involve these highly toxic chemicals.
AB 1788 was cosponsored by the Animal Legal Defense Fund, Center for Biological Diversity, and Raptors Are The Solution. The bill was also supported by Earth Island's Project Coyote.
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Scrambled eggs are my favorite!! They are definitely one of my favorite things for breakfast & they keep me full until lunch. I often get questions on how to get the creamy scramble down, so I thoughts I'd try to do a step by step with how I make it!


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We were lucky to catch a break in the clouds while conducting and ERT survey in the hills on the Highlands. The scenery was a well-deserved reward after a backpacking trip to the site.
This a story from BBC News about a 20m deep sinkhole that appeared on A26 in Kent. Luckily nobody has been hurt. This is just an example how useful geophysical technics can be for infrastructure inspections.
We have change our address from 111 Gallowgate, Aberdeen to 12a Carden Place, Aberdeen AB10 1UR. The change is effective from 1st of February.
Here is an example of a successful GPR survey carried out at Chapel of Saint Lesmo at Glentanar. In the first instance the response from the field data is not always very strong even though the GPR lines are spaced fairly close at 0.5m. Once the data has been processed and we have created slices trough the whole data we can see clear linear features appearing that can be easily identified as buried utilities that were unknown of until the survey.
In this example we would like to show how 2D Electrical Resistivity Tomography, or for short ERT, can be visualized in 3D. The data is shown in context, using satellite imagery of the area.
We would like to thank SRUC Aberdeen for allowing us to share the data. The ERT section has been acquired on Scotland's oldest continuous crop testing field – Woodland.


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Sharon, Strafford will decide ownership of Ashley Community Forest next year
By ANNA MERRIMAN
Published: 11/2/2020 9:12:44 PM
Modified: 11/2/2020 9:12:38 PM
STRAFFORD — Residents in Sharon and Strafford will be asked to vote early next year on a long-discussed measure to accept ownership of the 256-acre Ashley Community Forest, which straddles the line between the towns.
Selectboards in both towns recently decided to bring the issue to the public in Special Town Meeting ballot votes on Jan. 18, and both boards are still finalizing the language of the question that they'll put to voters.
Sharon Selectboard Chair Joseph Ronan said the date is a compromise for residents, some of whom wanted to put the measure up for a vote on Nov. 3, and others who wanted to wait until Town Meeting in the spring. In a Strafford Selectboard meeting last week, the board decided it would "be best to hold the vote on the same day" as Sharon, according to minutes from the Oct. 26 meeting.
The forest was purchased in 2018 by the Alliance for Vermont Communities, partly to save the land from being acquired by David Hall, the Utah engineer who at the time was proposing the controversial "NewVistas" development in the area.
The AVC always intended on donating the forest to the two towns, and initially suggested the towns take ownership of the entire parcel in a joint partnership, said Orange County Forester Dave Paganelli, a Strafford resident who serves on the Ashley Community Forest Committee.
But Selectboard members in both Sharon and Strafford disagreed, saying instead that they would each own only the section of forest that sat within their town lines.
"The board feels it is in the town's best interest to own Strafford's portion of the forest and to allow Sharon to own their portion. The board agreed to try to manage the land cooperatively with Sharon and to share the same Conservation Easement," the minutes from Strafford's Oct. 26 board meeting said.
In addition to the land donation, the AVC would provide $20,000 "to cover initial management expenses," Paganelli said, adding that, in time the committee expects the towns will be able to pay for upkeep of the forest through the timber revenue it brings in.
"It would be self-sustaining forest and would never require a significant input of money from the towns," he said.
He said the forest would be an ideal spot for recreational activities like snowshoeing, skiing and hiking. On top of that, the land could be used for educational programming for local schools, though the towns will need to discuss building a larger parking lot in order to be accessible to school buses, he said.
"There are two old foundation sites that are in beautiful condition," he said, adding that the historic foundations are evidence of homes and old farms that once sat on the property.
Ronan said he was trying to stay neutral about the proposal. He said it was a "good project," though it raised some financial concerns for him.
"Part of it is what the town wants in terms of property. Mountain biking and walking trails will cost more," he said, suggesting it might be a better idea to set up a nonprofit to run the property. "We just borrowed $1 million to fix a road in Sharon. Doesn't that suggest that any incremental budget requirements might not be such a good idea?"
However, he said, the towns will have ample time to discuss the project and any financial concerns in the 2½ months leading up to the ballot question, during which the Sharon board plans to hold more informational sessions for residents.
Anna Merriman can be reached at amerriman@vnews.com or 603-727-3216.


Lt. Gov. Dan Patrick and House Speaker Joe Straus had their first meeting in months on Monday.
"The Speaker and I had a substantive meeting today where we discussed a lot of issues. We are still talking," Patrick said in an emailed statement.
The two Republican leaders — who have traded barbs over issues like the "bathroom bill" and school finance since the 30-day special legislative session began — have a history of frosty relations.
A contentious bill giving homeowners more power to resist annexation failed to progress in the House after a procedural hang-up Monday. But lawmakers said they expect a revised version to be back up for consideration by week's end.
WASHINGTON — Texas Sen. John Cornyn could be on a collision course with some home-state mayors over a push to combat so-called sanctuary cities.
A bill announced last week by the Republican would go after cities that do "not cooperate with federal law enforcement authorities" on immigration matters by withholding federal dollars from violators for certain programs that "that are important to mayors and local communities," he said.
That's a nonstarter for many Texas mayors, who are already fighting anti-sanctuary policies on several fronts.
Austin's new Central Library will have a grand opening Oct. 28, the city said in a news release Monday.
The long-delayed, $125 million library has been under construction for more than four years at 710 W. Cesar Chavez St. At 200,000 square feet, it's double the size of Faulk Central Library, which it will replace, and it will include hip features like a cooking demonstration space, a technology "petting zoo" where people can play with new devices, solar panels, rainwater collection, an event center and a restaurant. It was first set to open in November 2016, then May 2017.


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Here's why the Bears traded Robert Quinn
Bryan Perez October 27, 2022 October 27, 2022
Chicago Bears general manager Ryan Poles's decision to trade Robert Quinn wasn't easy. Quinn is one year removed from setting the Bears' single-season sack record and was, by all accounts, one of the team's leaders in the locker room.
Now, he's a member of the Philadelphia Eagles.
For a team in transition, moving a 32-year-old pass-rusher for a quality draft pick — a 2023 fourth-round pick — is smart. It will allow young players like Trevis Gipson and Dominique Robinson to get more playing time while adding another quality rookie to the roster next spring.
And Poles feels good about that.
"My job is to do what's best for this organization not only now, but in the future," Poles said Wednesday. "I really do trust in Gipson, he's had a good start to the season; (Al-Quadin) Muhammad, he's brought intensity and toughness to that group, and even young Robinson has flashed, he tipped that ball that Roquan got the other day and has a promising future and I think he's going to continue to trend upwards."
2022 Season, News
Previous: Twitter reacts to Bears trading Robert Quinn to Eagles
Next: 2023 NFL Draft: Updated first-round order entering Week 8


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Scenic Group Travel Policy and Advisory Update: COVID-19
OPERATIONAL UPDATES
On behalf of all the Scenic Group team, we hope that your families, friends and you are all well. There has been significant progress made with global vaccinations, however, the timeframes for the full vaccination roll-out continues to vary significantly for each region in which we operate. While we are making every effort to operate our cruise and land journey itineraries, the emergence of new COVID variants and outbreaks, the extension of lockdowns in hotspots, changes in quarantine requirements and attraction closures, and civil unrest in Myanmar are continuing to impact our industry. .
This means that it is currently not possible for us to operate the Egypt and Middle East land journeys which were scheduled to depart from 1 January to 31 May 2022 and New Zealand land journeys scheduled until 31 January 2022. As previously advised, Australia land journeys and Scenic Eclipse voyages have been suspended to 31 December 2021, Europe Rver Cruises have been suspended to 28 February, 2022, and Asia River Cruises have been suspended to 31 May 2022. International land journeys have also been suspended to 31 January 2022.
The flexible conditions for your Future Travel Credit (FTC) are as follows:
Departure Period - 2021
FTC Voucher
Value of FTC
Can I use FTC with other brands?
What Can I apply the FTC to?
Can I transfer the FTC?
Europe River cruise reservations departing from August 1, 2021 - February 28, 2022
100% Up to December 31, 2024 FTC is based on the amount paid for your reservation to date FTC can be applied to any booking within the Scenic Group The FTC can be applied to any existing booking or when re-booking your future travel The FTC is fully transferrable to another guest.
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100% Up to June 30, 2024 FTC is based on the amount paid for your reservation to date FTC can be applied to any booking within the Scenic Group The FTC can be applied to any existing booking or when re-booking your future travel The FTC is fully transferrable to another guest.
Ocean cruise reservation departing from October 1 to December 31, 2021
Land tours reservation: Africa tours departing from January 1, 2021 to July 31, 2021; Canada tours departing from January 1 to December 31 2021; Australia tours departing from July 12-December 31, 2021
100% Up to June 30, 2024 FTC is based on the amount paid for your reservation to date
FTC can be applied to any booking within the Scenic Group The FTC can be applied to any existing booking or when re-booking your future travel
The FTC is fully transferrable to another guest.
Land tours reservation: Africa tours departing from August 1 2021 to December 31 2021
100% Up to December 31, 2024 FTC is based on the amount paid for your reservation to date
Land tours reservation: Any departing September 1, 2021 to January 31, 2022 including Middle East land journeys through May 31, 2022
Upon the expiry of the FTC on June 30, 2024 or December 31, 2024, guests who choose not to travel may contact us to receive a cash refund equal to the amount paid.
+For guests with a Mekong River Cruise departing or an Irrawaddy River Cruise departing from September 1, 2021 to May 31, 2022, we will provide a Future Travel Credit (FTC) for the full amount that has been paid to date.
*The FTC cannot be applied against stand-alone products or upgrades from third parties or Service Providers (as defined in our Terms and Conditions) in conjunction with the standard tour itinerary
Guests Holding Future Bookings
The safety of our guests and crew remains our first priority and we are closely monitoring this constantly evolving situation. New updates relating to the suspension of operations will be provided up to 2 months prior to your cruise or tour departure date. You can stay up to date with the policy information on this page, and if your booking is affected by a future suspension, you will be contacted as a priority.
Re-booking using a Future Travel Credit
With many people now planning and looking forward to traveling in 2022 and 2023, we have started to see increasing demand for popular cruise and tour destinations, departures and suites.
To re-book your preferred departure with your Future Travel Credit (FTC), or if you have any questions regarding the above or the FTC process, please contact your Travel Advisor or the Scenic Group Reservations team at +1-855-517-1200.
Our Flexible Booking and Cancellation Policy
All guests with an international land journey or Europe river cruise booking scheduled to depart from 1 January to 31 December 2022, or Asia river cruise departing to 28 February 2023, or Scenic Eclipse cruise departing to 31 December 2023, have the option to defer their booking to an alternate date or cancel without the Scenic Group fee, up to 60 days prior to departure. For cancellations, the value of the booking will be applied as a Future Travel Credit (FTC) which is valid for 24 months.
Please note, the final payment is due as per your booking conditions, and if you choose to cancel or transfer there may be third party fees applicable, which will be at your own expense. This flexible booking and cancellation policy excludes Russia, South America, Australia and New Zealand land touring.
We will continue to monitor the changing global situation and remain committed to doing our best to assist with your concerns and adjusting travel plans. On behalf of the Scenic Group team, we are here to support you during this challenging period and look forward to exploring our precious world with you again soon using the Future Travel Credit.
Q. What should I do next?
A. If we cannot operate your departure as scheduled, then Scenic Group will send you an auto notification letter, for the booking with the applicable Future Travel Voucher details. We will automatically apply the Future Travel Voucher on your record so there is no need to take any immediate action. Our reservations team will be working through these bookings in departure date order and would appreciate your patience in waiting for us to contact you. This will ensure we process the changes as quickly as possible. However, if you would like to secure your reservation now for a future travel date please contact your Scenic or Emerald Cruises/Evergreen Travel Agent or our reservations team.
Q. What is the current situation and when do you expect to operate again?
We are closely monitoring the changing global situation and will continue to take guidance from Government advisory notifications and travel restrictions (including port and border closures). The inability to operate our schedules applies to all Scenic Group cruise and tour departures up to December 31, 2021 and Asia River Cruising through May 31, 2022.
Q. What is your policy if I cancel my booking for a cruise or tour which remains scheduled to depart
A. If you choose not to take up the option of the Future Travel Credit for any cruise or tour that remains scheduled to depart, you may opt to cancel your booking under our standard terms and conditions. You can then consult with your travel insurance company to enquire if you are eligible to lodge a claim. If required, we can provide a letter to assist you in making your claim.
Q. Is there a flexible booking policy for Future Travel Credit holders?
The below flexible booking policy applies when using a Future Travel Credit (FTC) to re-book:
• Included flexible cover means you can re-book with confidence and protection.
• You can defer travel after re-booking up to 60 days prior to travel*, with no Scenic Group fees (3rd party fees may apply).
• Should you need to cancel your re-booking, you can do so up to 60 days prior to travel*, with no Scenic Group fee (3rd party fees may apply). Your FTC will then be held for a further 24 months to use on a future departure.
• Final payment is due as per your booking conditions. However, changes can be made up to 60 days prior to travel*, with no Scenic Group fee (3rd party fees may apply).
This policy applies to guests who have been affected by a booking that has been unable to operate or who have cancelled their booking voluntarily under our COVID policy.
*Excluding Russia and South America
Q. What is a Third Party Fee?
A. Third party fees are incurred by Scenic Group when we contract with other travel partners to help package your itinerary. This may include airlines, hotels, Russian River cruises, Dalmatia Ocean Cruises coach and limousine transfers, exclusive access to venues and charters. In these circumstances, Scenic is subject to the third party terms and conditions and needs to make a claim for the costs incurred to deliver the services within your booking. For example, an airline may apply an amendment or cancellation fee on your air ticket.
Q. What is a Future Travel Credit?
The Future Travel Credit (FTC) provides flexibility for you to re-book a land tour, river or ocean cruise for travel in 2021 to 2024 as outlined in communication provided for the date of departure of your suspended reservation.
The Future Travel Credit (FTC) is fully transferrable to another guest, booking or other Scenic Group brand.
Q. Is my Future Travel Credit combinable with all other offers available at the time of booking?
A. Some conditions may apply to the use of your FTC and they may not be combinable with limited promotions, such as Deposit Protection Plan, Super Earlybird Offers and Early Payment Discount.
Q. Do I Still Get Scenic Group Status Points for the booking that is unable to proceed?
A. No, as guests will receive a Future Travel Credit this is not applicable. However, upon re-booking you will accrue Scenic Group Status points on the selected departure once your journey has been completed.
Q. Can I extend my final payment? (All departures and all destinations)
A. Yes, we understand your concerns around payment final payment in the current environment. Please contact our reservations team to request a final payment extension review.
* Excludes Russia, South America, Canada, Australia and New Zealand
Q. What are your on board safety and health protocols?
Scenic Group will ensure that we adhere to the highest standards of hygiene and cleaning protocols on all ships and all tours when operating. Thorough cleaning will be conducted regularly, and hand sanitisers are located throughout the ship to ensure the highest level of personal hygiene whilst on board. For further information, refer to our Cruise with Confidence information for:-
Read our statement from the Scenic Group Chairman and Founder, Glen Moroney, here.
We appreciate that the situation is constantly evolving and it can be quite overwhelming to make future travel plans. We will continue to update you as much as possible through our websites. If you have any further questions please contact our Reservations Centre and we appreciate your patience as there may be delays due to the unusual higher volume of calls.


text:
Stupid by Tate Mcrae
Overview. Total views, likes or dislikes have been reached by "Stupid" as summary. Earnings and Net Worth. Interactive graphics based on weekly views and history of all chart achieves for this music video.
Tate Mcrae - Stupid (Lyrics)
Vote for "Stupid"
"Stupid" has reached 92.7K total views, 2.1K likes, and 34 dislikes. It has been submitted at 13/01/2020 and spent 1 weeks on the charts. For all times when appearing in charts, the song achieved 46.4K average weekly views.
Weekly Chart Achieves (Top 40 Songs)
The highest charting position of the entry is #150 . The video has reached most views on week #263 , acquiring 92.7K views on YouTube. The worst ranking place of the video is #150. "Stupid" has been charted in 1 trends (countries):
Canada Top 40 Chart
Canada Top 40 / week #263
The highest ranking position of the entry is #150 . The video has achieved most views on 14/01/2020, acquiring 76.4K views on YouTube. The song appeared 1 total times in the Top 100 ; The worst charting place of the entry is #31. Find all daily charts - Top 100 Canada


I love the fall, and having fun little ones to share it with is a blast. In the last couple of weeks we've been to the Scarecrow festival and Cornbelly's at Thanksgiving Point. We've also been to the big red barn at Stoneridge Farms in Santaquin, UT for apples, hayrides, a pumpkin patch, and delicious apple donuts and cider.
We had fun getting lost in the corn maze!
My friend Amanda and her cute kids Courtney, Peyton, and Aubrey joined us. The kids ate it up...literally.


A Pakistani high court judge who publicly accused the country's powerful intelligence service of manipulating judicial decisions to influence the last general election was removed from his post Thursday.
A notification issued by the ministry of law and Justice said the country's president had removed Shaukat Aziz Siddiqui from his office with immediate effect.
The role of the military and Inter Services Intelligence in politics is rarely discussed openly in Pakistan due to fear of repercussions.
But in a public speech delivered days before the July elections, Siddiqui had accused the ISI of being fully involved in manipulating judicial process, including the selection of judges, and conspiring to keep ousted former prime minister Nawaz Sharif behind bars during the polls.
In his speech to lawyers in Rawalpindi, Siddiqui said the spy agency was involved in corrupt practices including providing aid in the commission of offences and receiving their share from crime money.
He added, People from ISI approached my boss and said We do not want to let Nawaz Sharif and his daughter come out [of the prison] until elections.
On Thursday, the Supreme Judicial Council - the country's top body of judges - said Siddiqui had displayed conduct unbecoming of a judge of a High Court and was thus guilty of misconduct.
I am constrained to observe that local police is in league with the mighty agencies who have disrupted the civic fibre of the country, Siddiqui said in a written order concerning a petition about enforced disappearances.