text:
Team Detroit to Showcase First-to-Market Consumer Targeted Initiatives at South by Southwest (SXSW) Interactive Festival
Team Detroit
DEARBORN, Mich., March 5, 2015 /PRNewswire/ -- WPP's Team Detroit, a leading global advertising and design agency, is returning to South by Southwest (SXSW) to showcase a few "industry firsts" with a panel discussion on the history, success, and future of The Car Customizer, as well as, a partnership with Pandora to experiment with listening data to identify three trending artists who will perform live at a private agency event during the festival.
SXSW Panel:
Reinventing the Car Customizer... Again
311 E. 5th
Panel Description: In 2009 we attempted to put a new spin on configuring a car by adding some fantasy and fun to an otherwise tedious journey in the shopper funnel. The results were astounding. The "Customizer" became a lightning rod for creativity in a space typically owned by functionality. Many future car customization in the online space followed suit.
Krysty Sagnia – SVP, Managing Partner, Team Detroit
Andrea Zuehlk - Car Digital Marketing Manager, Ford Motor Company
Stuart O'Neil – Group Creative Director, Team Detroit
Christian Colasuonno – Executive Digital Producer, Team Detroit
Pandora's proprietary algorithm, the Music Genome, fuels personalization and music discovery for listeners.
For several years, Team Detroit and Pandora have partnered together to tap into the music consumption insights that stem from the Music Genome to support innovative, digital, branding campaigns for Team Detroit's key client initiatives.
This year at SXSW, Team Detroit will again leverage Pandora's listening data in an experiential capacity to identify three trending artists who will perform live at Team Detroit's private agency event. Team Detroit has partnered with Pandora on several first-to-market initiatives, including leveraging the connected car to serve Pandora listeners targeted marketing messages through in-car integration.
Team Detroit at SXSW
Team Detroit is offering two full days of programming during SXSW. In addition to senior keynote speakers and an immersive hands-on Technology Lounge, highlights from day two include the "60 Seconds to SXSW" student recruiting promotion - developed in partnership with composting and urban farming organization Detroit Dirt - where three teams from around the country have been chosen as finalists to pitch their ideas for a new Creative campaign.
Austin SOUP, a unique crowd funding competition, encourages leaders in the community to pitch their ideas for social good and community outreach. According to U.S.A. President David Murphy, "Austin SOUP is about people. It's about connecting and empowering people, and giving them what they need to make a difference in their own community. We're looking forward to leaving something good behind."
Team Detroit's Presence at SXSW is enhanced by the following: Adaptly, DataXu, TapAd, Pandora, Data Logix, Microsoft, AOL, Cars.com, Visible Measures, and Twitter. Learn more at www.Teamdetroit.com.
About Team Detroit
Based in Dearborn, Michigan, Team Detroit was founded in 2007 as an entirely new model of collaboration that gives marketers access to the breadth of WPP's talent, ideas and tools. The agency has 36 U.S. offices and employs more than 3,000 worldwide. Clients include Ford Motor Company, Ford Dealers, Johnson Controls, Ohio Art and the United Way of Southeast Michigan. Visit www.teamdetroit.com for more information.
SOURCE Team Detroit
http://www.teamdetroit.com


A: "I finished my first senior semester, started my senior capstone which is a volleyball launcher. The volleyball launcher will have a functioning prototype by the end of my senior year."
Q: What are some short term goals that you'd like to accomplish?
A: "Finishing my senior capstone and having a fully functional prototype. I'd also like to get a job in my desired field upon graduation."


Concept videos for each topic and subtopic.
Assessment with video solutions for the complex problems.
Valid certification on successful completion of the course.
Step 4: Login here https://app.placementseason.com/ and the respective test can be taken at the courses section.


text:
"use strict" ;

/* global AggregateError */

const Promise = require( './seventh.js' ) ;

// This object is used as a special unique value for array hole (see Promise.filter())
const HOLE = {} ;

function noop() {}

Promise.all = ( iterable ) => {
	var index = -1 , settled = false ,
		count = 0 , length = Infinity ,
		value , values = [] ,
		allPromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		const promiseIndex = ++ index ;

		Promise.resolve( value )
			.then(
				value_ => {
					if ( settled ) { return ; }

					values[ promiseIndex ] = value_ ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						allPromise._resolveValue( values ) ;
					}
				} ,
				error => {
					if ( settled ) { return ; }
					settled = true ;
					allPromise.reject( error ) ;
				}
			) ;
	}

	length = index + 1 ;

	if ( ! length ) {
		allPromise._resolveValue( values ) ;
	}

	return allPromise ;
} ;

// Maybe faster, but can't find any reasonable grounds for that ATM
//Promise.all =
Promise._allArray = ( iterable ) => {
	var length = iterable.length ;

	if ( ! length ) { Promise._resolveValue( [] ) ; }

	var index ,
		runtime = {
			settled: false ,
			count: 0 ,
			length: length ,
			values: [] ,
			allPromise: new Promise()
		} ;

	for ( index = 0 ; ! runtime.settled && index < length ; index ++ ) {
		Promise._allArrayOne( iterable[ index ] , index , runtime ) ;
	}

	return runtime.allPromise ;
} ;

// internal for allArray
Promise._allArrayOne = ( value , index , runtime ) => {
	Promise._bareThen( value ,
		value_ => {
			if ( runtime.settled ) { return ; }

			runtime.values[ index ] = value_ ;
			runtime.count ++ ;

			if ( runtime.count >= runtime.length ) {
				runtime.settled = true ;
				runtime.allPromise._resolveValue( runtime.values ) ;
			}
		} ,
		error => {
			if ( runtime.settled ) { return ; }
			runtime.settled = true ;
			runtime.allPromise.reject( error ) ;
		}
	) ;
} ;

Promise.allSettled = ( iterable ) => {
	var index = -1 , settled = false ,
		count = 0 , length = Infinity ,
		value , values = [] ,
		allPromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		const promiseIndex = ++ index ;

		Promise.resolve( value )
			.then(
				value_ => {
					if ( settled ) { return ; }

					values[ promiseIndex ] = { status: 'fulfilled' , value: value_ } ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						allPromise._resolveValue( values ) ;
					}
				} ,
				error => {
					if ( settled ) { return ; }

					values[ promiseIndex ] = { status: 'rejected' ,  reason: error } ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						allPromise._resolveValue( values ) ;
					}
				}
			) ;
	}

	length = index + 1 ;

	if ( ! length ) {
		allPromise._resolveValue( values ) ;
	}

	return allPromise ;
} ;

// Promise.all() with an iterator
Promise.every =
Promise.map = ( iterable , iterator ) => {
	var index = -1 , settled = false ,
		count = 0 , length = Infinity ,
		value , values = [] ,
		allPromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		const promiseIndex = ++ index ;

		Promise.resolve( value )
			.then( value_ => {
				if ( settled ) { return ; }
				return iterator( value_ , promiseIndex ) ;
			} )
			.then(
				value_ => {
					if ( settled ) { return ; }

					values[ promiseIndex ] = value_ ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						allPromise._resolveValue( values ) ;
					}
				} ,
				error => {
					if ( settled ) { return ; }
					settled = true ;
					allPromise.reject( error ) ;
				}
			) ;
	}

	length = index + 1 ;

	if ( ! length ) {
		allPromise._resolveValue( values ) ;
	}

	return allPromise ;
} ;

/*
	It works symmetrically with Promise.all(), the resolve and reject logic are switched.
	Therefore, it resolves to the first resolving promise OR reject if all promises are rejected
	with, as a reason an AggregateError of all promise rejection reasons.
*/
Promise.any = ( iterable ) => {
	var index = -1 , settled = false ,
		count = 0 , length = Infinity ,
		value ,
		errors = [] ,
		anyPromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		const promiseIndex = ++ index ;

		Promise.resolve( value )
			.then(
				value_ => {
					if ( settled ) { return ; }

					settled = true ;
					anyPromise._resolveValue( value_ ) ;
				} ,
				error => {
					if ( settled ) { return ; }

					errors[ promiseIndex ] = error ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						anyPromise.reject( new AggregateError( errors ) , 'Promise.any(): All promises have rejected' ) ;
					}
				}
			) ;
	}

	length = index + 1 ;

	if ( ! length ) {
		anyPromise.reject( new RangeError( 'Promise.any(): empty array' ) ) ;
	}

	return anyPromise ;
} ;

// Like Promise.any() but with an iterator
Promise.some = ( iterable , iterator ) => {
	var index = -1 , settled = false ,
		count = 0 , length = Infinity ,
		value ,
		errors = [] ,
		anyPromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		const promiseIndex = ++ index ;

		Promise.resolve( value )
			.then( value_ => {
				if ( settled ) { return ; }
				return iterator( value_ , promiseIndex ) ;
			} )
			.then(
				value_ => {
					if ( settled ) { return ; }

					settled = true ;
					anyPromise._resolveValue( value_ ) ;
				} ,
				error => {
					if ( settled ) { return ; }

					errors[ promiseIndex ] = error ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						anyPromise.reject( new AggregateError( errors , 'Promise.some(): All promises have rejected' ) ) ;
					}
				}
			) ;
	}

	length = index + 1 ;

	if ( ! length ) {
		anyPromise.reject( new RangeError( 'Promise.some(): empty array' ) ) ;
	}

	return anyPromise ;
} ;

/*
	More closed to Array#filter().
	The iterator should return truthy if the array element should be kept,
	or falsy if the element should be filtered out.
	Any rejection reject the whole promise.
*/
Promise.filter = ( iterable , iterator ) => {
	var index = -1 , settled = false ,
		count = 0 , length = Infinity ,
		value , values = [] ,
		filterPromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		const promiseIndex = ++ index ;

		Promise.resolve( value )
			.then( value_ => {
				if ( settled ) { return ; }
				values[ promiseIndex ] = value_ ;
				return iterator( value_ , promiseIndex ) ;
			} )
			.then(
				iteratorValue => {
					if ( settled ) { return ; }

					count ++ ;

					if ( ! iteratorValue ) { values[ promiseIndex ] = HOLE ; }

					if ( count >= length ) {
						settled = true ;
						values = values.filter( e => e !== HOLE ) ;
						filterPromise._resolveValue( values ) ;
					}
				} ,
				error => {
					if ( settled ) { return ; }
					settled = true ;
					filterPromise.reject( error ) ;
				}
			) ;
	}

	length = index + 1 ;

	if ( ! length ) {
		filterPromise._resolveValue( values ) ;
	}
	else if ( count >= length ) {
		settled = true ;
		values = values.filter( e => e !== HOLE ) ;
		filterPromise._resolveValue( values ) ;
	}

	return filterPromise ;
} ;

// forEach performs reduce as well, if a third argument is supplied
// Force a function statement because we are using arguments.length, so we can support accumulator equals to undefined
Promise.foreach =
Promise.forEach = function( iterable , iterator , accumulator ) {
	var index = -1 ,
		isReduce = arguments.length >= 3 ,
		it = iterable[Symbol.iterator]() ,
		forEachPromise = new Promise() ,
		lastPromise = Promise.resolve( accumulator ) ;

	// The array-like may contains promises that could be rejected before being handled
	if ( Promise.warnUnhandledRejection ) { Promise._handleAll( iterable ) ; }

	var nextElement = () => {
		lastPromise.then(
			accumulator_ => {
				let { value , done } = it.next() ;
				index ++ ;

				if ( done ) {
					forEachPromise.resolve( accumulator_ ) ;
				}
				else {
					lastPromise = Promise.resolve( value ).then(
						isReduce ?
							value_ => iterator( accumulator_ , value_ , index ) :
							value_ => iterator( value_ , index )
					) ;

					nextElement() ;
				}
			} ,
			error => {
				forEachPromise.reject( error ) ;

				// We have to eat all remaining promise errors
				for ( ;; ) {
					let { value , done } = it.next() ;
					if ( done ) { break ; }

					//if ( ( value instanceof Promise ) || ( value instanceof NativePromise ) )
					if ( Promise.isThenable( value ) ) {
						value.then( noop , noop ) ;
					}
				}
			}
		) ;
	} ;

	nextElement() ;

	return forEachPromise ;
} ;

Promise.reduce = ( iterable , iterator , accumulator ) => {
	// Force 3 arguments
	return Promise.forEach( iterable , iterator , accumulator ) ;
} ;

/*
	Same than map, but iterate over an object and produce an object.
	Think of it as a kind of Object#map() (which of course does not exist).
*/
Promise.mapObject = ( inputObject , iterator ) => {
	var settled = false ,
		count = 0 ,
		keys = Object.keys( inputObject ) ,
		length = keys.length ,
		outputObject = {} ,
		mapPromise = new Promise() ;

	for ( let i = 0 ; ! settled && i < length ; i ++ ) {
		const key = keys[ i ] ;
		const value = inputObject[ key ] ;

		Promise.resolve( value )
			.then( value_ => {
				if ( settled ) { return ; }
				return iterator( value_ , key ) ;
			} )
			.then(
				value_ => {
					if ( settled ) { return ; }

					outputObject[ key ] = value_ ;
					count ++ ;

					if ( count >= length ) {
						settled = true ;
						mapPromise._resolveValue( outputObject ) ;
					}
				} ,
				error => {
					if ( settled ) { return ; }
					settled = true ;
					mapPromise.reject( error ) ;
				}
			) ;
	}

	if ( ! length ) {
		mapPromise._resolveValue( outputObject ) ;
	}

	return mapPromise ;
} ;

// Like map, but with a concurrency limit
Promise.concurrent = ( limit , iterable , iterator ) => {
	var index = -1 , settled = false ,
		running = 0 ,
		count = 0 , length = Infinity ,
		value , done = false ,
		values = [] ,
		it = iterable[Symbol.iterator]() ,
		concurrentPromise = new Promise() ;

	// The array-like may contains promises that could be rejected before being handled
	if ( Promise.warnUnhandledRejection ) { Promise._handleAll( iterable ) ; }

	limit = + limit || 1 ;

	const runBatch = () => {
		while ( ! done && running < limit ) {

			//console.log( "Pre" , index ) ;
			( { value , done } = it.next() ) ;

			if ( done ) {
				length = index + 1 ;

				if ( count >= length ) {
					settled = true ;
					concurrentPromise._resolveValue( values ) ;
					return ;
				}
				break ;
			}

			if ( settled ) { break ; }

			const promiseIndex = ++ index ;
			running ++ ;
			//console.log( "Launch" , promiseIndex ) ;

			Promise.resolve( value )
				.then( value_ => {
					if ( settled ) { return ; }
					return iterator( value_ , promiseIndex ) ;
				} )
				.then(
					value_ => {
					//console.log( "Done" , promiseIndex , value_ ) ;
						if ( settled ) { return ; }

						values[ promiseIndex ] = value_ ;
						count ++ ;
						running -- ;

						//console.log( "count/length" , count , length ) ;
						if ( count >= length ) {
							settled = true ;
							concurrentPromise._resolveValue( values ) ;
							return ;
						}

						if ( running < limit ) {
							runBatch() ;
							return ;
						}
					} ,
					error => {
						if ( settled ) { return ; }
						settled = true ;
						concurrentPromise.reject( error ) ;
					}
				) ;
		}
	} ;

	runBatch() ;

	if ( index < 0 ) {
		concurrentPromise._resolveValue( values ) ;
	}

	return concurrentPromise ;
} ;

/*
	Like native Promise.race(), it is hanging forever if the array is empty.
	It resolves or rejects to the first resolved/rejected promise.
*/
Promise.race = ( iterable ) => {
	var settled = false ,
		value ,
		racePromise = new Promise() ;

	for ( value of iterable ) {
		if ( settled ) { break ; }

		Promise.resolve( value )
			.then(
				value_ => {
					if ( settled ) { return ; }

					settled = true ;
					racePromise._resolveValue( value_ ) ;
				} ,
				error => {
					if ( settled ) { return ; }

					settled = true ;
					racePromise.reject( error ) ;
				}
			) ;
	}

	return racePromise ;
} ;

redpajama_set_name: RedPajamaGithub


text:
require 'tomlrb'

module LicenseFinder
  class Dep < PackageManager
    def possible_package_paths
      [project_path.join('Gopkg.lock')]
    end

    def current_packages
      toml = Tomlrb.load_file(detected_package_path)
      projects = toml['projects']

      return [] if projects.nil?

      projects.map do |project|
        GoPackage.from_dependency({
                                    'ImportPath' => project['name'],
                                    'InstallPath' => project_path.join('vendor', project['name']),
                                    'Rev' => project['revision'],
                                    'Homepage' => repo_name(project['name'])
                                  }, nil, true)
      end
    end

    def repo_name(name)
      name.split('/')[0..2].join('/')
    end

    def self.takes_priority_over
      Go15VendorExperiment
    end

    def prepare_command
      'dep ensure -vendor-only'
    end

    def package_management_command
      'dep'
    end
  end
end


We're bringing the JusCollege Spring Break experience to Miami! Spend the day at beach and pool parties, and hang out at South Beach's hottest clubs at night. There are no other Spring Break experiences of this caliber in Miami.
Book now to secure your space before it sells out!
Prices starts at $499/person for a 5-nights. Small deposit due today w/ final payment due 2/15. Payments after 2/15 will be pay in full.


text:
Main Speakers
The International Society for NonParametric Statistics (ISNPS) was founded in 2010 with the mission "to foster the research and practice of nonparametric statistics, and to promote the dissemination of new developments in the field via conferences, books and journal publications."
ISNPS has a distinguished Advisory Committee that includes R.Beran, P.Bickel, R. Carroll, D. Cook, P. Hall, W. Hardle, R. Johnson, B. Lindsay, E. Parzen, P. Robinson, M. Rosenblatt, G. Roussas, T. SubbaRao, and G. Wahba. The Charting Committee of ISNPS consists of over 50 prominent researchers from all over the world.
The nature of ISNPS is uniquely global, and its international conferences are designed to facilitate the exchange of ideas and latest advances among researchers from all around the world in cooperation with established statistical societies such as the Institute of Mathematical Statistics (IMS) and the International Statistical Institute (ISI).
The First Conference of ISNPS is scheduled to take place in Chalkidiki, Northern Greece, June 15-19, 2012 (with participants arriving on June 14), and is co-sponsored by the IMS, the ISI, and other organizations. The venue is the G-Hotel complex: http://www.ghotels.gr/ enlocated 40 miles (60 Km) away from Thessaloniki (also know as Salonica) which is Greece's 2nd largest city. Thessaloniki has an international airprot with direct conections to many European cities; a sampler includes: London, Rome, Berlin, Munich, Frankfurt, Dusseldorf, Stutgard, Zurich, Budapest, and Bucharest. Thessaloniki's IATA 3-letter airport code is SKG.
The conference will bring forth recent advances and trends in several areas of nonparametric statistics, in order to facilitate the exchange of research ideas, promote collaboration among researchers from all over the world, and contribute to the further development of the field. The program will include plenary talks, special invited talks, invited talks, contributed talks and posters on all areas of nonparametric statistics. A round table discussion on the constitution of ISNPS and future conferences will also take place.
Researchers that are interested in ISNPS and/or would like to participate in its First Conference by giving a contributed talk or poster are encouraged to contact ISNPS at the email: This e-mail address is being protected from spambots. You need JavaScript enabled to view it
Looking forward to seeing you in June!
The Organizers:
M.G. Akritas, S.N. Lahiri, and D.N. Politis
Executive committee of ISNPS
Valid XHTML & CSS - Template Design ah-68 - Copyright © 2011 by HRG GREECE

redpajama_set_name: RedPajamaCommonCrawl


Our client was a tenant in a block of flats in Kent which was let by the defendant in this case. Our client was ascending a set of communal stairs when a plastic edging detached from one of the steps causing our client to fall and suffer personal injury and loss.
Our client stated that there had been previous problems with the stair edging coming away and had been reported by numerous tenants in the block to their landlord.
What did Hayward Baker Solicitors to do help?
Gary Lee one of our senior personal injury claims handlers took on the case on a No Win No Fee basis and submitted the claim through the low value personal injury claims on-line portal setting out why the defendant was responsible for the accident.
a) Failing to keep the common parts of the premises in a state of good repair as per your obligations under provisions ss 11 and 12 of the Landlord and Tenant Act 1985, or under an express or implied term of the tenancy agreement between the parties, or as a result of the provisions of the Occupiers' Liability Act 1957 or otherwise.
b) Failing to inspect the stairs and ensure that the same were safe for the use of tenants.
c) Failing to heed previous problems with the edging of the stairs and takes measures to ensure that the stairs were safe.
d) Failing to ensure that the edging of the stairs was sufficiently fixed to the stair so that it could not detach.
After a small period of investigation by the defendant insurers they confirmed to Hayward Baker via the portal that liability was admitted.
This mean't that provided that a medical report confirms our client was injured as a result of the accident, they have agreed to pay our client compensation, and Gary will of course discuss with our client the level of compensation after receipt of the medical report.
Gary arranged for our client to be examined by an Orthopaedic Consultant and sent off for copies of our client's medical records from her GP and Hospital which the expert will need to see prior to the appointment. After the examination the expert will formulate a report upon our client's injuries and this report will be used to prove our client's injuries and aid Gary in valuing the claim for compensation.
On receipt of the medial report Gary reviewed it and sent a copy to our client for approval along with a schedule of out of pocket expenses claim which covered the following items:.
Our client promptly approved the medical report and signed the consent forms to allow Gary to try and settle the claim now with the defendant insurers.


text:
October 6, 2009 In Culture, Economy, Education, Environment, International, Internet, Philosophy, Politics, Science By Tony Winders
Bill Clinton's Win-Win Philosophy
I attended a talk by the 42nd President of the U.S., William Jefferson Clinton last night at the Thousand Oaks Civic Arts Plaza, part of the Distinguished Speaker Series. Packing a wealth of stories, stats and a good sense of humor, he promised and then delivered a framework we can all use to make sense of today's complex world in which we live. Wondering about what caused the financial meltdown of September 15, 2008? How about our education crisis (according to Clinton we slipped from first to tenth in the past decade)? Or how we're to "win" in Afghanistan? For most of us, it takes every bit of our energy to deal with life's immediate challenges, let alone trying to sort fact from fiction from all the information we're bombarded with in today's fragmented and often biased media ecosystem. His talk gave a fresh perspective on how to interpret the world today and some guidance on what we can do to affect change.
The number one definining characteristic of the 21st century is our global interdependence. The result of our diversity and new technologies like the Internet carry with it both good and bad consequences. Posit for a moment that we know the good things, namely technology. Most of the bad consequences of our interconnectedness are defined by inequality and instability.
Inequalityis presented primarily in education and income. One billion people live on less than $1 per day, one billion people will go hungry tonight and one billion don't have access to clean water. One quarter of everyone who dies on the planet this year will be due to tuberculosis, malaria, AIDS or dirty water. And of the dirty water victims 80 perent will be under five years old. In the U.S., 90 percent of our growth in recent years has gone to 10 percent of the population.
Instabilityis created by how quickly thing can spread, from terrorism (easy access to information) to Swine Flue (permeability and uprootedness) to the world financial crisis (inter-connectedness of financial systems). Even with $3 trillion in cash, a whopping 2 million factory workers in China are unemployed because the rest of the world is not buying as much of their exports.
In light of the complexities in our interconnected world, we need a framework from which to act. How do we respond to these many challenges? Not more liberally, but in a more "communitarian" fashion — more succinctly put, by focusing on creating win-win situations. For every situation or decision, he asks "will this bring us closer together or tear us further apart?"
Prime examples where "win-win" has worked are in Iraq where the people ultimately declared a common enemy in Al Qaeda. In Tanzania where our continued efforts to finance AIDS and Malaria relief have demonstrated our commitment their children. And in Rwanda, where the Tutsi leader insisted his post-genocide successor be a Hutu, and engraining in his people the need for win-win by granting land to those who would live next door to someone from the rival tribe.
Another timely example of searching for win-win was through a clear explanation of health carereform, including the back-story on "death panels," and distinctions between terms like "public option" and "socialized medicine." Every year we spend 17 percent of our income on health care– money consumers aren't investing in other things, which gives other countries that much more of an advantage over us on the world economic stage. The bottom line: if you're not for some kind of change in health care, you are a proponent of win-lose, not win-win.
One of the things that stood out for me most was Clinton's commentary on the differences between being a sitting president and a former president. "The good news is, you can say anything you like," he said. "The bad news is that nobody cares about what you have to say…that is, unless your wife happens to be Secretary of Sate."
While this was met with laughter, it was obvious everyone should care about what this former president has to say. He is using his clout and connections through the William J. Clinton Foundation to make a difference in the lives of millions through several thoughtful initiatives. And while he has raised hundreds of millions from the wealthiest people in the world, he stressed the importance of each individual being called into service in some way. He spoke of the secret of the U.S. economy having always been the strength of our middle class, and how this group must now stand and help the U.S. regain its footing in our inter-connected world. "It's not enough to work and pay taxes, raise a good family and show up to vote." There are one million public service groups to which we can donate our time and expertise, over half of which were started in the last year.
While it's of course possible to donate to the Clinton Foundation, he did not make a direct pitch but rather spoke about Kiva.org, where for $25 you can make the difference in the life of someone anywhere in the world whom the group has already vetted as qualified for needing assistance.
Something else that resonated with me personally, and I don't think he would have said as president, is how we treat others is dependent upon our own identity and what we think about ourselves. Identity is highly complex, but we need to realize how much we are all alike. In fact, the argument in genomic circles is whether we are genetically 99.5 or 99.9 percent alike. By continually forcing ourselves to communicate with the other side we become more comfortable with one another. When we see how alike we are, we eventually decide that it's less costly to work with together than to keep killing each other and we collaborate in the interest of finding win-win situations. It is imperative in the modern world that we leave the door open.
While everything President Clinton had to say was in line with my own opinions, I hope his thoughtful presentation gave those of every political persuasion a new perspective on tolerance and possibility. It was awe-inspiring for me to hear this brilliant mind, speaking in his familiar and reassuring tone of so many examples of hope and of what is possible if we work together and apply ourselves to overcoming our collective challenges, be they local or global.
Think win-win and dedicate yourself to some form of public service. And when you do, I hope you'll let me know about it.
August 5, 2009 In Community, Economy, Friends and Colleagues, Marketing, Online Advertising, Online Marketing By Tony Winders
Plugged In, Charging Up
The Los Angeles Business Journal article referenced in my last post came out yesterday and I thought Charles Proctor did a superb job profiling the current state of the technology industry in Los Angeles. The article, entitled "Special Report: Plugged In, Charging Up" goes into great detail comparing employment trends in the technology sector in Los Angeles with that of Silicon Valley, including how our diversified market helped LA recover faster from the dot-com crash and the way aerospace engineers transfered their expertise to industries like computer science and medical devices in the post-Cold War era.
Carrying the technology industry in 2009 is a robust games industry, alternative fuel vehicles and renewable energy and digital media and marketing. I'm quoted as saying "This is a major media location and it has a big, big talent pool," said Tony Winders, a vice president at Westlake Village-based ValueClick Inc., a publicly traded Internet advertising company. "So the tech community settled in here as a hub for the digital advertising business."
It was fun being asked to contribute to this piece, but even more encouraging to read an article with some quantifiable details about how well our local technology community is faring these days. Hats off to Mr. Proctor for his thoughtful, quantitative analysis, and A BIG THANK YOU to Nicole Jordan for the introduction.
June 21, 2009 In Business, Content, Economy, Entertainment, Online Entertainment, Video By Tony Winders
The Economics of Online Entertainment
I've been thinking a lot about the economics of online entertainment lately, in part based on a June 15, 2009 LA Times article entitled 'Hollywood hits the stop button on high-profile Web video efforts." Despite many failed attempts at monetizing online entertainment content, ranging from DEN, Icebox and POP.com in the late 90s to Stage 9 Digital and 60Frames in recent months, I'm not convinced there isn't a profitable model for making the studio model of the future a reality.
Whatever the successful combination, it is certain to be as complex and dynamic as the changing media landscape itself. It will include both traditional and yet untested advertising and sponsorship models, but it won't be fully reliant on them either. It will include brave new brand extensions and cross-platform integration and ways to interact with audiences that result in them eagerly spending their hard earned money on e-commerce and subscriptions and engaging with sponsors.
It will also include strategies with no intent of directly driving revenue, but still being accountable to some other practical revenue stream — offline purchases, participation in events, engagement in online communities, etc. Or for large media carriers to support membership/subscription-based services and any myriad of other business objectives.
Making quality online entertainment content is hard, but building an audience for it from scratch is even harder. This reality has been part of what makes it difficult to monetize the emerging category of web video content with any scale. The model that works will include an innovative way for content producers to attract and retain large new audiences in a way that presents clear value for each of the key stakeholders: content creators, distributors and consumers.
Many more layers of this oninion to be peeled in the weeks ahead I'm sure.
Speaking of identifying good online entertainment content, as a fan of Weeds, I was interested to learn from Tubefilter about University of Andy, a series of short videos in which Andy Botwin (played by Justin Kirk) lectures on various life skills that are not likely to be offered at the local community college, but are guaranteed to make you laugh.
June 10, 2009 In Behavioral Targeting, Economy, Online Advertising, Privacy By Tony Winders
Economic Value of the Ad-Supported Internet
I'm impressed by how the Interactive Advertising Bureau has stepped up to answer the call for industry self regulation and the creative ways it is demonstrating to Congress and the FTC the importance of online advertising to the U.S. economy. In a a report out today entitled "Economic Value of the Advertising-Supported Internet Ecosystem," the IAB suggests online advertising is responsible for employing 3.1 million Americans and generating $300 billion, or 2.1 percent of the U.S. GDP.
Coinciding with the release of the report, this week the IAB is hosting a series of meetings and a press conference in Washington, D.C. dubbed the "IAB Long Tail Alliance Fly-In." The event is intended to put real faces to the individuals and small businesses that benefit from online advertising and comprise a portion of the revenue and jobs cited in the Economic Value report. Some of those faces are represented in this video called "I Am the Long Tail."
The report and this week's activities in D.C. are a testament to Randy Rothenberg's leadership and have created a strong foundation for demonstrating that our industry takes seriously the call for self-regulation. But the rubber will meet the road when the IAB and other trade groups with whom it has partnered publish more formal recommendations about how to allay consumer and regulator concerns surrounding behavioral targeting and consumer privacy protection.
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Vassy JL, Stone A, Callaghan JT, Mendes M, Meyer LJ, Pratt VM, Przygodzki RM, Scheuner MT, Wang-Rodriguez J, Schichman SA. Response to Gammal et al. Genet Med. 2019 Jan 11. PMID: 30635623.
Saad MA, Ku J, Kuo SZ, Li PX, Zheng H, Yu MA, Wang-Rodriguez J, Ongkeko WM. Identification and characterization of dysregulated P-element induced wimpy testis-interacting RNAs in head and neck squamous cell carcinoma. Oncol Lett. 2019 Mar; 17(3):2615-2622. PMID: 30854037.
Kuo SZ, Honda CO, Li WT, Honda TK, Kim E, Altuna X, Abhold E, Wang-Rodriguez J, Ongkeko WM. Metformin Results in Diametrically Opposed Effects by Targeting Non-Stem Cancer Cells but Protecting Cancer Stem Cells in Head and Neck Squamous Cell Carcinoma. Int J Mol Sci. 2019 Jan 07; 20(1). PMID: 30621095.
Vassy JL, Stone A, Callaghan JT, Mendes M, Meyer LJ, Pratt VM, Przygodzki RM, Scheuner MT, Wang-Rodriguez J, Schichman SA. Pharmacogenetic testing in the Veterans Health Administration (VHA): policy recommendations from the VHA Clinical Pharmacogenetics Subcommittee. Genet Med. 2018 Jun 01. PMID: 29858578.
Li WT, Zheng H, Nguyen V, Wang-Rodriguez J, Ongkeko WM. Functional Genomics Profiling of Bladder Urothelial Carcinoma MicroRNAome as a Potential Biomarker. Neoplasia. 2018 04; 20(4):364-373. PMID: 29544183.
Zheng H, Li P, Kwok JG, Korrapati A, Li WT, Qu Y, Wang XQ, Kisseleva T, Wang-Rodriguez J, Ongkeko WM. Alcohol and hepatitis virus-dysregulated lncRNAs as potential biomarkers for hepatocellular carcinoma. Oncotarget. 2018 Jan 02; 9(1):224-235. PMID: 29416609.
Wang-Rodriguez J, Yunes A, Phan R, Ma N, Baddoura F, Mosse C, Kim AS, Lu CM, Dong DZM, Schichman S, Icardi M, Ehsan A. The Challenges of Precision Medicine and New Advances in Molecular Diagnostic Testing in Hematolymphoid Malignancies: Impact on the VHA. Fed Pract. 2017 Aug; 34(Suppl 5):S50-S61. PMID: 30766310.
Zheng H, Zou AE, Saad MA, Wang XQ, Kwok JG, Korrapati A, Li P, Kisseleva T, Wang-Rodriguez J, Ongkeko WM. Alcohol-dysregulated microRNAs in hepatitis B virus-related hepatocellular carcinoma. PLoS One. 2017; 12(5):e0178547. PMID: 28562643.
Zou AE, Zheng H, Saad MA, Rahimy M, Ku J, Kuo SZ, Honda TK, Wang-Rodriguez J, Xuan Y, Korrapati A, Yu V, Singh P, Grandis JR, King CC, Lippman SM, Wang XQ, Hinton A, Ongkeko WM. The non-coding landscape of head and neck squamous cell carcinoma. Oncotarget. 2016 08 09; 7(32):51211-51222. PMID: 27323410.
Yu V, Singh P, Rahimy E, Zheng H, Kuo SZ, Kim E, Wang-Rodriguez J, Ongkeko WM. RNA-seq analysis identifies key long non-coding RNAs connected to the pathogenesis of alcohol-associated head and neck squamous cell carcinoma. Oncol Lett. 2016 Oct; 12(4):2846-2853. PMID: 27698869.
Yu V, Rahimy M, Korrapati A, Xuan Y, Zou AE, Krishnan AR, Tsui T, Aguilera JA, Advani S, Crotty Alexander LE, Brumund KT, Wang-Rodriguez J, Ongkeko WM. Electronic cigarettes induce DNA strand breaks and cell death independently of nicotine in cell lines. Oral Oncol. 2016 Jan; 52:58-65. PMID: 26547127; PMCID: PMC4891196 [Available on 01/01/17].
Saad MA, Kuo SZ, Rahimy E, Zou AE, Korrapati A, Rahimy M, Kim E, Zheng H, Yu MA, Wang-Rodriguez J, Ongkeko WM. Alcohol-dysregulated miR-30a and miR-934 in head and neck squamous cell carcinoma. Mol Cancer. 2015 Oct 15; 14:181. PMID: 26472042; PMCID: PMC4608114.
Zou AE, Ku J, Honda TK, Yu V, Kuo SZ, Zheng H, Xuan Y, Saad MA, Hinton A, Brumund KT, Lin JH, Wang-Rodriguez J, Ongkeko WM. Transcriptome sequencing uncovers novel long noncoding and small nucleolar RNAs dysregulated in head and neck squamous cell carcinoma. RNA. 2015 Jun; 21(6):1122-34. PMID: 25904139; PMCID: PMC4436665.
Sebesta EM, Mirheydar HS, Parsons JK, Wang-Rodriguez J, Kader AK. Primary mucin-producing urothelial-type adenocarcinoma of the prostatic urethra diagnosed on TURP: a case report and review of literature. BMC Urol. 2014 May 22; 14:39. PMID: 24885582; PMCID: PMC4059493.
Ongkeko WM, Burton D, Kiang A, Abhold E, Kuo SZ, Rahimy E, Yang M, Hoffman RM, Wang-Rodriguez J, Deftos LJ. Parathyroid hormone related-protein promotes epithelial-to-mesenchymal transition in prostate cancer. PLoS One. 2014; 9(1):e85803. PMID: 24465715; PMCID: PMC3899059.
Kinseth MA, Jia Z, Rahmatpanah F, Sawyers A, Sutton M, Wang-Rodriguez J, Mercola D, McGuire KL. Expression differences between African American and Caucasian prostate cancer tissue reveals that stroma is the site of aggressive changes. Int J Cancer. 2014 Jan 01; 134(1):81-91. PMID: 23754304; PMCID: PMC3800217.
Kuo SZ, Blair KJ, Rahimy E, Kiang A, Abhold E, Fan JB, Wang-Rodriguez J, Altuna X, Ongkeko WM. Salinomycin induces cell death and differentiation in head and neck squamous cell carcinoma stem cells despite activation of epithelial-mesenchymal transition and Akt. BMC Cancer. 2012 Nov 24; 12:556. PMID: 23176396; PMCID: PMC3522015.
An Y, Kiang A, Lopez JP, Kuo SZ, Yu MA, Abhold EL, Chen JS, Wang-Rodriguez J, Ongkeko WM. Cigarette smoke promotes drug resistance and expansion of cancer stem cell-like side population. PLoS One. 2012; 7(11):e47919. PMID: 23144836; PMCID: PMC3489897.
Zhang S, Chen L, Wang-Rodriguez J, Zhang L, Cui B, Frankel W, Wu R, Kipps TJ. The onco-embryonic antigen ROR1 is expressed by a variety of human cancers. Am J Pathol. 2012 Dec; 181(6):1903-10. PMID: 23041612; PMCID: PMC3509760.
Zhang S, Chen L, Cui B, Chuang HY, Yu J, Wang-Rodriguez J, Tang L, Chen G, Basak GW, Kipps TJ. ROR1 is expressed in human breast cancer and associated with enhanced tumor-cell growth. PLoS One. 2012; 7(3):e31127. PMID: 22403610; PMCID: PMC3293865.
Abhold EL, Kiang A, Rahimy E, Kuo SZ, Wang-Rodriguez J, Lopez JP, Blair KJ, Yu MA, Haas M, Brumund KT, Altuna X, Patel A, Weisman RA, Ongkeko WM. EGFR kinase promotes acquisition of stem cell-like properties: a potential therapeutic target in head and neck squamous cell carcinoma stem cells. PLoS One. 2012; 7(2):e32459. PMID: 22384257; PMCID: PMC3288103.
Abhold E, Rahimy E, Wang-Rodriguez J, Blair KJ, Yu MA, Brumund KT, Weisman RA, Ongkeko WM. Recombinant human erythropoietin promotes the acquisition of a malignant phenotype in head and neck squamous cell carcinoma cell lines in vitro. BMC Res Notes. 2011 Dec 21; 4:553. PMID: 22188703; PMCID: PMC3285115.
Wilson LD, Zaldivar FP, Schwindt CD, Wang-Rodriguez J, Cooper DM. Circulating T-regulatory cells, exercise and the elite adolescent swimmer. Pediatr Exerc Sci. 2009 Aug; 21(3):305-17. PMID: 19827454; PMCID: PMC4822516.
Carpenter PM, Dao AV, Arain ZS, Chang MK, Nguyen HP, Arain S, Wang-Rodriguez J, Kwon SY, Wilczynski SP. Motility induction in breast carcinoma by mammary epithelial laminin 332 (laminin 5). Mol Cancer Res. 2009 Apr; 7(4):462-75. PMID: 19351903.
Richmon JD, Wang-Rodriguez J, Thekdi AA. Ehlers-Danlos syndrome presenting as dysphonia and manifesting as tongue hypermobility: Report of 2 cases. Ear Nose Throat J. 2009 Feb; 88(2):E8-12. PMID: 19224471.
Lu Q, Nunez E, Lin C, Christensen K, Downs T, Carson DA, Wang-Rodriguez J, Liu YT. A sensitive array-based assay for identifying multiple TMPRSS2:ERG fusion gene variants. Nucleic Acids Res. 2008 Nov; 36(20):e130. PMID: 18794177; PMCID: PMC2582611.
Lopez JP, Wang-Rodriguez J, Chang CY, Sneh G, Yu MA, Pardo FS, Aguilera J, Ongkeko WM. Gefitinib (Iressa) potentiates the effect of ionizing radiation in thyroid cancer cell lines. Laryngoscope. 2008 Aug; 118(8):1372-6. PMID: 18475209.
Chen J, Guo L, Peiffer DA, Zhou L, Chan OT, Bibikova M, Wickham-Garcia E, Lu SH, Zhan Q, Wang-Rodriguez J, Jiang W, Fan JB. Genomic profiling of 766 cancer-related genes in archived esophageal normal and carcinoma tissues. Int J Cancer. 2008 May 15; 122(10):2249-54. PMID: 18241037.
Carpenter PM, Wang-Rodriguez J, Chan OT, Wilczynski SP. Laminin 5 expression in metaplastic breast carcinomas. Am J Surg Pathol. 2008 Mar; 32(3):345-53. PMID: 18300817.
Bibikova M, Yeakley JM, Wang-Rodriguez J, Fan JB. Quantitative expression profiling of RNA from formalin-fixed, paraffin-embedded tissues using randomly assembled bead arrays. Methods Mol Biol. 2008; 439:159-77. PMID: 18370102.
Lopez JP, Wang-Rodriguez J, Chang C, Chen JS, Pardo FS, Aguilera J, Ongkeko WM. Gefitinib inhibition of drug resistance to doxorubicin by inactivating ABCG2 in thyroid cancer cell lines. Arch Otolaryngol Head Neck Surg. 2007 Oct; 133(10):1022-7. PMID: 17938326.
Bibikova M, Chudin E, Arsanjani A, Zhou L, Garcia EW, Modder J, Kostelec M, Barker D, Downs T, Fan JB, Wang-Rodriguez J. Expression signatures that correlated with Gleason score and relapse in prostate cancer. Genomics. 2007 Jun; 89(6):666-72. PMID: 17459658.
Schwindt CD, Zaldivar F, Wilson L, Leu SY, Wang-Rodriguez J, Mills PJ, Cooper DM. Do circulating leucocytes and lymphocyte subtypes increase in response to brief exercise in children with and without asthma? Br J Sports Med. 2007 Jan; 41(1):34-40. PMID: 17021002; PMCID: PMC2465132.
Wang-Rodriguez J, Lopez JP, Altuna X, Chu TS, Weisman RA, Ongkeko WM. STI-571 (Gleevec) potentiates the effect of cisplatin in inhibiting the proliferation of head and neck squamous cell carcinoma in vitro. Laryngoscope. 2006 Aug; 116(8):1409-16. PMID: 16885745.
Ongkeko WM, An Y, Chu TS, Aguilera J, Dang CL, Wang-Rodriguez J. Gleevec suppresses p63 expression in head and neck squamous cell carcinoma despite p63 activation by DNA-damaging agents. Laryngoscope. 2006 Aug; 116(8):1390-6. PMID: 16885742.
Li HR, Wang-Rodriguez J, Nair TM, Yeakley JM, Kwon YS, Bibikova M, Zheng C, Zhou L, Zhang K, Downs T, Fu XD, Fan JB. Two-dimensional transcriptome profiling: identification of messenger RNA isoform signatures in prostate cancer from archived paraffin-embedded cancer specimens. Cancer Res. 2006 Apr 15; 66(8):4079-88. PMID: 16618727.
Zhang C, Li HR, Fan JB, Wang-Rodriguez J, Downs T, Fu XD, Zhang MQ. Profiling alternatively spliced mRNA isoforms for prostate cancer classification. BMC Bioinformatics. 2006 Apr 11; 7:202. PMID: 16608523; PMCID: PMC1458362.
Chen JS, Pardo FS, Wang-Rodriguez J, Chu TS, Lopez JP, Aguilera J, Altuna X, Weisman RA, Ongkeko WM. EGFR regulates the side population in head and neck squamous cell carcinoma. Laryngoscope. 2006 Mar; 116(3):401-6. PMID: 16540898.
Zaldivar F, Wang-Rodriguez J, Nemet D, Schwindt C, Galassetti P, Mills PJ, Wilson LD, Cooper DM. Constitutive pro- and anti-inflammatory cytokine and growth factor response to exercise in leukocytes. J Appl Physiol (1985). 2006 Apr; 100(4):1124-33. PMID: 16357073.
Ongkeko WM, Altuna X, Weisman RA, Wang-Rodriguez J. Expression of protein tyrosine kinases in head and neck squamous cell carcinomas. Am J Clin Pathol. 2005 Jul; 124(1):71-6. PMID: 15923166.
Bibikova M, Yeakley JM, Chudin E, Chen J, Wickham E, Wang-Rodriguez J, Fan JB. Gene expression profiles in formalin-fixed, paraffin-embedded tissues obtained with a novel assay for microarray analysis. Clin Chem. 2004 Dec; 50(12):2384-6. PMID: 15563488.
Wang-Rodriguez J, Urquidi V, Rivard A, Goodison S. Elevated osteopontin and thrombospondin expression identifies malignant human breast carcinoma but is not indicative of metastatic status. Breast Cancer Res. 2003; 5(5):R136-43. PMID: 12927044; PMCID: PMC314424.
Wang-Rodriguez J, Dreilinger AD, Alsharabi GM, Rearden A. The signaling adapter protein PINCH is up-regulated in the stroma of common cancers, notably at invasive edges. Cancer. 2002 Sep 15; 95(6):1387-95. PMID: 12216108.
Wang-Rodriguez J, Cross K, Gallagher S, Djahanban M, Armstrong JM, Wiedner N, Shapiro DH. Male breast carcinoma: correlation of ER, PR, Ki-67, Her2-Neu, and p53 with treatment and survival, a study of 65 cases. Mod Pathol. 2002 Aug; 15(8):853-61. PMID: 12181271.
Tyrberg B, Anachkov KA, Dib SA, Wang-Rodriguez J, Yoon KH, Levine F. Islet expression of the DNA repair enzyme 8-oxoguanosine DNA glycosylase (Ogg1) in human type 2 diabetes. BMC Endocr Disord. 2002 Apr 25; 2(1):2. PMID: 12003641.
Welsh JB, Sapinoso LM, Su AI, Kern SG, Wang-Rodriguez J, Moskaluk CA, Frierson HF, Hampton GM. Analysis of gene expression identifies candidate markers and pharmacological targets in prostate cancer. Cancer Res. 2001 Aug 15; 61(16):5974-8. PMID: 11507037.
Wang-Rodriguez J, Fry E, Fiebig E, Lee T, Busch M, Mannino F, Lane TA. Immune response to blood transfusion invery-low-birthweight infants. Transfusion. 2000 Jan; 40(1):25-34. PMID: 10644808.
Bashey A, Shepherd S, Frankel W, Wang-Rodriguez J, Cahill T, Chamberlain M, Mason JR, Ho AD, Corringham RE. Induction of molecular remission by donor peripheral blood leukocyte therapy in patients relapsing with extramedullary blastic phase chronic myeloid leukemia after allogeneic bone marrow transplantation. Oncol Rep. 1998 Jan-Feb; 5(1):281-5. PMID: 9458334.
Wang-Rodriguez J, Rearden A. Reduced frequency of HLA-DQ6 in individuals with a positive direct antiglobulin test. Transfusion. 1996 Nov-Dec; 36(11-12):979-84. PMID: 8937408.
Frankel W, Chan A, Corringham RE, Shepherd S, Rearden A, Wang-Rodriguez J. Detection of chimerism and early engraftment after allogeneic peripheral blood stem cell or bone marrow transplantation by short tandem repeats. Am J Hematol. 1996 Aug; 52(4):281-7. PMID: 8701946.
Wang-Rodriguez J, Mannino FL, Liu E, Lane TA. A novel strategy to limit blood donor exposure and blood waste in multiply transfused premature infants. Transfusion. 1996 Jan; 36(1):64-70. PMID: 8607157.
Wang-Rodriguez J, Rearden A. Effect of crossmatching on outcome in organ transplantation. Crit Rev Clin Lab Sci. 1995; 32(4):345-76. PMID: 7576157.


To I° 38' E.) but inland Togoland widens to three or four times that breadth.
Just below the crown of tentacles, however, the body widens out to form a " head," termed the hydranth (a), containing a stomach-like dilatation of the digestive cavity.
On the north is the Charles river, which widens here into a broad, originally much broader, inner harbour or back-bay.
In Rio Grande do Sul, where two large lakes have been created by uplifted sand beaches, the coastal plain widens greatly, and is merged in an extensive open, rolling grassy plain, traversed by ridges of low hills (cuchillas), similar to the neighbouring republic of Uruguay.
This ingenious operation widens the track at the expense of an unimportant fraction of its length.
After leaving the Central Provinces, the river widens out in the fertile district of Broach, with an average breadth of z m.
At Coblenz the valley widens and the river is 1200 ft.
At Toungoo it is narrow, but below Shwegyin it widens, and at Sittang it is half a mile broad.
It widens into what was called by Maury the Telegraph Plateau.
The West Atlantic Trough lying on the western side of the Central Rise widens in the north into the North American Basin, and its, greatest depths appears to be in the Porto Rico Trench, where in 1882 Capt.
The valley now widens out into the rich district of Hamah (Hamath-Epiphaneia), below which lie the broad meadow-lands of Ghab, containing the sites of ancient Apamea and Larissa.
In width, and to the northward it widens to too m.
From Devil's Point, a sharp promontory on the north bank - up to which place the water is salt - the river widens considerably and enters the Atlantic, in about 132° N.
As in the north-east, so in the south-west, the crystalline belt widens and gains in height; but while New England is an indivisible unit, the southern crystalline belt must be subdivided The Southinto a higher mountain belt on the north-west, 60 m.
Farther south, the mountain belt widens and attains its greatest development, a true highland district, in North Carolina, where it includes several strong mountain groups.
(of Texas); but it again widens to 300 m.
Every five or ten years the annual scarcity widens its area and becomes a recognized famine; every fifty or a hundred years whole provinces are involved, loss of life becomes widespread, and a great famine is recorded.
It is only at the mouth of the Eleutherus and at Acre (`Akka) that the strip of coast-land widens out into plains of any size; there is a certain amount of open country behind Beirut; but for the most part the mountains, pierced by deep river-valleys, approach to within a few miles of the coast, or even right down to the sea, as at Ras en-Nakura (Scala Tyrioruin, Jos.
On the west the belt is narrow, but towards the east it gradually widens, and north of Lago di Garda its northern boundary is suddenly deflected to the north and the zone spreads out so as to include the whole of the Dolomite mountains of Tirol.
Towards the north end of the island the spurs of the main chain sometimes extend towards the neighbourhood of the east coast and the eastern plain widens from north to south.
Below the junction of the Fier the hills sink on either side, the channel of the river widens, and one may say that it leaves the mountains for the plains.
The river now widens, but the neighbouring country is much exposed to inundations.
In the south this is very narrow; it widens towards the north savewhere the Cameroon peak reaches to the sea.
On entering Mysore it passes through a narrow gorge, but presently widens to an average breadth of 300 to 4 00 yds.
Upstream from that point, but is generally taken to embrace the whole valley from its source to a point near Jervaulx abbey, a distance of nearly 40 m., below which the valley widens out upon the plain.
Southward it widens out and forms Lake Kasse (20 m.
On the northern side of the range which separates the upper Bukhtarma from the upper Katun is the Katun glacier, which after two ice-falls widens out to 700-900 yards.
The east coast faces the shallow North Sea, which widens from the point where it joins the Channel to 375 m.
Not so drop C, for directly the summit is passed the wind necessarily widens out vertically and, having a greater space to fill, loses forward velocity.
Above this entrance it widens into an ellipse a mile long, half a mile broad and 15 ft.
The inside shape of the producer is such that the upper, less hot portion cannot get stopped, as it widens out towards the bottom; the lower, hotter portion, where the ashes are already fluxed, is contracted to a slit a, through which the air ascends.
At low water, but presently widens to 12 m.
Below the Greben, the Prigrada rocky bank nearly blocked the river at the point where it widens out after leaving the Kazan defile.
In places, as at Lere and Bifara, it widens into lake-like dimensions.
It consists of a compressed intermolar portion with a flat upper surface, broad behind and becoming narrower in front, and of a depressed anterior part rather shorter than the former, which is narrow behind and widens towards the evenly rounded apex.
The fact that the light widens out toward the sun leads to the inference that it entirely surrounds the sun.
End the hills again recede and the plain widens to include Dweru.


text:
Browsing publications of the research group of molecular bacteriology(MOBA) by Subjects
Department of molecular bacteriology (MOBA)
publications of the research group of molecular bacteriology(MOBA)
A chemical proteomics approach to identify c-di-GMP binding proteins in Pseudomonas aeruginosa.
Düvel, Juliane; Bertinetti, Daniela; Möller, Stefan; Schwede, Frank; Morr, Michael; Wissing, Josef; Radamm, Lena; Zimmermann, Bastian; Genieser, Hans-Gottfried; Jänsch, Lothar; et al. (2012-02)
In many bacteria, high levels of the ubiquitous second messenger c-di-GMP have been demonstrated to suppress motility and to promote the establishment of surface-adherent biofilm communities. While molecular mechanisms underlying the synthesis and degradation of c-di-GMP have been comprehensively characterized, little is known about how c-di-GMP mediates its regulatory effects. In this study, we have established a chemical proteomics approach to identify c-di-GMP interacting proteins in the opportunistic pathogen Pseudomonas aeruginosa. A functionalized c-di-GMP analog, 2'-aminohexylcarbamoyl-c-di-GMP (2'-AHC-c-di-GMP), was chemically synthesized and following its immobilization used to perform affinity pull down experiments. Enriched proteins were subsequently identified by high-resolution mass spectrometry. 2'-AHC-c-di-GMP was also employed in surface plasmon resonance studies to evaluate and quantify the interaction of c-di-GMP with its potential target molecules in vitro. The biochemical tools presented here may serve the identification of novel classes of c-di-GMP effectors and thus contribute to a better characterization and understanding of the complex c-di-GMP signaling network.
Cross talk between the response regulators PhoB and TctD allows for the integration of diverse environmental signals in Pseudomonas aeruginosa.
Bielecki, Piotr; Jensen, Vanessa; Schulze, Wiebke; Gödeke, Julia; Strehmel, Janine; Eckweiler, Denitsa; Nicolai, Tanja; Bielecka, Agata; Wille, Thorsten; Gerlach, Roman G; et al. (2015-07-27)
Two-component systems (TCS) serve as stimulus-response coupling mechanisms to allow organisms to adapt to a variety of environmental conditions. The opportunistic pathogen Pseudomonas aeruginosa encodes for more than 100 TCS components. To avoid unwanted cross-talk, signaling cascades are very specific, with one sensor talking to its cognate response regulator (RR). However, cross-regulation may provide means to integrate different environmental stimuli into a harmonized output response. By applying a split luciferase complementation assay, we identified a functional interaction of two RRs of the OmpR/PhoB subfamily, namely PhoB and TctD in P. aeruginosa. Transcriptional profiling, ChIP-seq analysis and a global motif scan uncovered the regulons of the two RRs as well as a quadripartite binding motif in six promoter regions. Phosphate limitation resulted in PhoB-dependent expression of the downstream genes, whereas the presence of TctD counteracted this activation. Thus, the integration of two important environmental signals e.g. phosphate availability and the carbon source are achieved by a titration of the relative amounts of two phosphorylated RRs that inversely regulate a common subset of genes. In conclusion, our results on the PhoB and TctD mediated two-component signal transduction pathways exemplify how P. aeruginosa may exploit cross-regulation to adapt bacterial behavior to complex environments.
Deep transcriptome profiling of clinical Klebsiella pneumoniae isolates reveals strain and sequence type-specific adaptation.
Bruchmann, Sebastian; Muthukumarasamy, Uthayakumar; Pohl, Sarah; Preusse, Matthias; Bielecka, Agata; Nicolai, Tanja; Hamann, Isabell; Hillert, Roger; Kola, Axel; Gastmeier, Petra; et al. (2015-11)
Health-care-associated infections by multi-drug-resistant bacteria constitute one of the greatest challenges to modern medicine. Bacterial pathogens devise various mechanisms to withstand the activity of a wide range of antimicrobial compounds, among which the acquisition of carbapenemases is one of the most concerning. In Klebsiella pneumoniae, the dissemination of the K. pneumoniae carbapenemase is tightly connected to the global spread of certain clonal lineages. Although antibiotic resistance is a key driver for the global distribution of epidemic high-risk clones, there seem to be other adaptive traits that may explain their success. Here, we exploited the power of deep transcriptome profiling (RNA-seq) to shed light on the transcriptomic landscape of 37 clinical K. pneumoniae isolates of diverse phylogenetic origins. We identified a large set of 3346 genes which was expressed in all isolates. While the core-transcriptome profiles varied substantially between groups of different sequence types, they were more homogenous among isolates of the same sequence type. We furthermore linked the detailed information on differentially expressed genes with the clinically relevant phenotypes of biofilm formation and bacterial virulence. This allowed for the identification of a diminished expression of biofilm-specific genes within the low biofilm producing ST258 isolates as a sequence type-specific trait.


text:
Police arraign 60 Shiites for homicide, public disturbance
Ade Adesomoju
Federal High Court, Abuja
Ade Adesomoju, Abuja
The police on Wednesday arraigned 60 Shiite Muslims who are members of the Islamic Movement of Nigeria, on charges of culpable homicide, destruction of public property and constituting public disturbance.
The defendants, who were arrested in the aftermath of the their July 22, 2019 protest in Abuja, were arraigned before the High Court of the Federal Capital Territory, Abuja.
They pleaded not guilty to the charges, which were read in English and interpreted to them in Hausa language.
A Deputy Commissioner of Police, Usman Umar, and one National Youth Service Corps member, Precious Owolabi, who was serving with Channels Television, had died in the violence that erupted during the clash between the police and the Shiites during the July 22, 2019 protest.
[READ ALSO] IPPIS: FG says lecturers enrolling, despite ASUU's opposition
Following the not-guilty plea of the defendants, the counsel prosecuting for the police, Simon Lough, urged the court to remand them in the Kuje Prison.
He noted that the defendants had been in the custody of the Special Anti-Robbery Squad of the Police Force in Abuja since their arrest in June.
Man impregnates 14-year-old daughter in Bayelsa
Gombe police arrest 109 over illegal business, entry into Nigeria
Arrest 'yahoo boys', don't collect their money - Pastor Ibiyeomie to police
Lough applied to the court to move its sitting to Kuje Prison due to the potential logistical challenges of transporting the 60 defendants to court for trial.
The defence counsel, Bala Dakum, did not oppose the prosecutor's request.
He, however, informed the court of his intention to move the bail application he filed on behalf of the defendants.
The trial judge, Justice Sulaiman Belgore, ordered that the defendants should be remanded in SARS custody till December 10 which he fixed for the hearing of the defendants' bail application.
Monalisa Chinda, Charles Inojie, Francis Duru, others for 'Philomena'
Robbers injure two drivers during operation in Kwara
Land agent dies in Ogun hotel after sex with ex-wife
Police rescue seven trafficked victims, repel bandits' attack in Katsina
May we not forget
Tags: homicide police public demonstrations Shiites


Our online safety training system allows managers and supervisors to quickly build industry-specific or organization-specific courses or policies and deliver them to all staff easily.
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text:
College of Business > News & Events > Management Faculty Member Named DePaul Presidential Fellow
Management Faculty Member Named DePaul Presidential Fellow
DePaul Newsline | Photo By Jeff Carion / 2/21/2019 / Twitter / Facebook
Associate Professor of Management Alyssa Westring
Alyssa Westring, associate professor of management & entrepreneurship at the Driehaus College of Business, has been appointed by DePaul University as one of its two inaugural Presidential Fellows.
Westring and Christina Rivers, associate professor of political science, were named fellows in a new research program created by DePaul President A. Gabriel Esteban to examine diversity and inclusion issues influencing the recruitment, retention and success of diverse faculty, staff and students at DePaul.
Westring will evaluate DePaul's culture to identify opportunities to enhance the engagement, retention and career advancement for women and faculty of color, according to DePaul's Newsline. Rivers will lead an effort for diverse faculty and students to form strong bonds through research, as well as a post-prison higher education initiative.
Westring joined DePaul's business faculty in 2007 after earning a PhD in industrial and organizational psychology from Michigan State University. A 2017 Excellence in Teaching Award winner, she teaches courses that focus on organizational behavior and career management. Her research explores the interplay of work, family and life. As a committee member of the Women in Entrepreneurship Institute at DePaul, she and colleagues are studying the barriers to success for women business founders.
Read more about Westring's appointment and the new Presidential Fellows program in Newsline.


All rights reserved. The copyright for any material published on this website is reserved. Any duplication or use of images, videos and/or texts is not permitted without Frank Hülsbömer's written agreement.
Frank Hülsbömer is not responsible for any contents linked or referred to from his website. The contents will not be checked and are subject to control and liability of the responsible provider. The use of published postal addresses, telephone or fax numbers and email addresses for marketing purposes is prohibited.


Conclusion: That's about it just a nice "looking" phone. While the rest of technology is advancing to the latest Android Operating System updates, Sony Ericsson Xperia X10, fall short.
First of all, I am a cell phone junkie! I am addicted to Phone Arena and Phone Scoop. I have read mixed reviews on the Xperia, and I am pleasantly disappointed. I find a very good looking phone, the screen is beautiful, and it runs great. It is a shame that it doesn't have the latest Android version, but that is not the end of the world. It is still Android, and I understand that there will be updates. People are not crazy about the keyboard. It's okay, but you can go to the Android Market and download "Better Keyboard". It's free! Make sure that you download Advanced Task Manager and your battery life will be much better. I think this phone deserves much better press than it has gotten.
SONY X10 Is a waste of phone.
Logging on to the Internet,I think dial up could be faster...and yes Iam in a 3G area with full bars. The unlock slider locks/freezes up half the time.The camera is the worst Ive seen yet on a phone in at least 2yrs, I can put it flat and picture will still be blurry, theres no focus even though it says it does, The flash is a joke..not even a flash just a really bright annoying light that doesnt even help in dark places. While on a call and I receive another I wont even ignore it, I will just let it keep ringing while still on the call and all the sudden the person that was calling me that I didnt want to speak with at the time is on the line. (this happens everytime I get another call while on a call). The sound is HORRIBLE!!! Both ways. I can not hear the other caller unless there is no noise at all, and still very low.The ringer is so low I miss a lot of calls.Music player sound is pointless.Randomly wont even make a noise for notifications/text...etc. So again I miss these as well.I will check the settings and everything will be set correct as I wanted, also I set a certain ring tone and when I get a call it doesn't even play it, plays default ringer. A LOT of dropped calls, with full bars and in 3G coverage and everyone else around has no problems,cant even get a call sent out half the time.The keys on the keyboard with touch always sticks, Space bar and Delete are the ones that I usually have the problems with.After writing a long note/text/status...etc I will touch the delete and it will stick and delete everything I had wrote and nothing will un freeze it.Iam VERY disappointed in this phone.I have always been a Sony lover, I've had lots of the sony phones and was always satisfied. This has been a shock to me that this phone is as crappy as it is.Maybe their needs to be some changes with this device,I guess Im going to look at the Samsung Galaxy/Captivate, I have read great reviews. Really wish this phone would work right, my excitement level is under zero.
I stopped in an AT&T store to test drive this phone.
Very slow and jerky web browsing performance when scrolling sites like Amazon.com.
The lack of pinch zoom also hinders use.
In my opinion even things like going into settings and scrolling/selecting items was just not very snappy.
Too bad, I had wanted this phone since it's release in Japan a year ago! But ... the newer devices (iPhone, HTC) are much more better performers.
I have an unlocked Rogers wireless X10a running on AT&T. After using this phone for over a month I am mostly satisfied with its performance. The combination of the 4 inch screen and 1 GHz processor result in a pleasant user experience. The phone shows very little lag except when using the Timescape interface. Timescape is still very usable but takes a few seconds to load if you include all your online accounts and media. The screen is bright enough that I use it at 25% brightness indoors. At 100% it is readable in bright sunlight. If you leave the APN (3G) enabled to get email, facebook, twitter etc. updates constantly and make quite a few phone calls the battery may not last you through a work day. Installing Process Manager and setting it to automatically terminate applications after 20 Mins. or 1 Hr. battery life will increase (you will need to tweak it to keep important applications open). Installing JuiceDefender and setting it to only enable the APN periodically can get you through a day but you loose automatic updates.
Large bright 4 Inch screen.
Very good phone radio performance.
Hardware Back, Menu and Home buttons work better than touch sensitive ones on many other phones.
8 Mega-pixel camera takes great pictures.
Fits nicely in average sized hand despite large screen.
Speaker call volume not very loud (it plays music at a fairly loud volume so the problem does not seem to be a hardware limit).
Battery life will be a problem for heavy users.
No video output (I don't need it).
No significant amount of built-in storage memory for data and applications.
Must wait until Sept. for Android 2.x update.
Font is very small (e.g. needed reading glasses to see contacts & numbers) and there is no way to enlarge the font.
Poor battery life - but I guess that is pretty standard for the large screen "smart phones."
This device is an enigma.If you read the cell site reviews the Xperia X10 gets very ho-hum grades but if you read actual owner experiences they are much more favorable. No excuse for SE shipping the X10 with OS 1.6 and AT&T/SE still hasn't offered the official 2.1 update.But if you can look past the older OS there is alot to like.The Xperia X10 is a beautiful device,especially in White.(Only avail at Best Buy)The Sony-based camera/video software is among the best on an Android device.On 1.6 the software runs smooth and fast.As a phone the Xperia gets very good reception though the call volume could be better.Good speakerphone for calls and music.SonyEricsson has very up & down reputation but the Xperia deserves a look.


Chess is incredibly popular at Junior Boys with over 100 pupils involved.
The emphasis is on enjoying the game and boys have the chance to play several times a week in clubs. There have been some significant successes in recent years with county champions and our boys playing for England.
Most competitive activity is physical, chess challenges the brain and will encourage your son to sit still and concentrate. As well as helping improve his patience, chess enhances the strategy and sequencing skills used in Maths and History.


Mere mortals beware, there's a dark cloud that looms, judgment day is afoot and Doom is your worst nightmare.
Born in Kingston, Jamaica, Doom moved to England permanently in 1980. From a young age he had a love of sporting competition, especially cricket.
He gained his first physical education and personal training qualifications whilst serving with the British Armed Forces. It was through the army that Doom was able to recognise his potential as an athlete and would attempt any competitive sport. Leaving the army he went on to pursue a career with the Physical Education Branch of the Metropolitan Police, where he established the rehabilitation department.
Representing Great Britain in Bobsleigh for over seven years, Doom is also an enthusiastic runner, and has competed in the 400m hurdles at county level and has completed a half-marathon. He's also wrestled at Olympic standard.
In 2008, Doom began the journey in training to be a stuntman, this gave him the opportunity to feature on shows such as The Bill, EastEnders, Holby City, Whistle Blower and his first speaking role on Spooks. His modeling career began several years ago when he was signed by MOT Model Agency, since then he has posed for Argos, Inter-sports, Tesco, Ultra-Fit, Sky and more.
Doom was one of two reserve male Gladiators for the first series of the Sky1 relaunch. He was initially going to be known as Stealth but when he became a fully fledged Gladiator in Series 2 he became the evil Doom!
Nowadays, Doom and his girlfriend Enigma (they met whilst Bobsleighing at the 2005 World Championships in Canada) pass on their knowledge and experiences to young people through school projects and workshops. They also run their personal fitness company Pace & Go where they encourage everyone to 'Be All You Can Be!'.


Hypereosinophilia of the myofibers (cardiac myocytee sarcoplasm) can be easily detected on examinaiton of H&E stained sections. It may not show frank coagulation necrosis. It may be accompanied by other changes such as wavy fibers (myofibers) as shown in this example.


text:
Q: Ionic build Android error when downloading Gradle I'm very new to the Ionic framework :)
>npm install -g cordova
>npm install -g ionic
>ionic start test blank
>cd test
>ionic platform add android

When I use '>ionic build android' start download gradle, but I can't download and get an error.
What caused this error and how can I fix it?!
I download Gradle and install it on a PC, but it wants to download again.
Can I add Gradle to a project offline?
C:\Users\LENOVO2014\test>ionic build android
running cordova build android
Running command: "C:\Program Files\nodejs\node.exe" C:\Users\LENOVO2014\myApp\ho
oks\after_prepare\010_add_platform_class.js C:\Users\LENOVO2014\myApp
add to body class: platform-android
Running command: C:\Users\LENOVO2014\myApp\platforms\android\cordova\build.bat
ANDROID_HOME=D:\program\Programing\Android\sdk
JAVA_HOME=C:\Program Files\Java\jdk1.8.0_31
Running: C:\Users\LENOVO2014\myApp\platforms\android\gradlew cdvBuildDebug -b C:
\Users\LENOVO2014\myApp\platforms\android\build.gradle -Dorg.gradle.daemon=true
Downloading http://services.gradle.org/distributions/gradle-2.2.1-all.zip
................................................................................
................................................................................
................................................................................
............................................
Exception in thread "main" java.lang.RuntimeException: java.net.SocketException:
 Connection reset
        at org.gradle.wrapper.ExclusiveFileAccessManager.access(ExclusiveFileAcc
essManager.java:78)
        at org.gradle.wrapper.Install.createDist(Install.java:47)
        at org.gradle.wrapper.WrapperExecutor.execute(WrapperExecutor.java:129)
        at org.gradle.wrapper.GradleWrapperMain.main(GradleWrapperMain.java:48)
Caused by: java.net.SocketException: Connection reset
        at java.net.SocketInputStream.read(SocketInputStream.java:189)
        at java.net.SocketInputStream.read(SocketInputStream.java:121)
        at java.io.BufferedInputStream.read1(BufferedInputStream.java:284)
        at java.io.BufferedInputStream.read(BufferedInputStream.java:345)
        at sun.net.www.MeteredStream.read(MeteredStream.java:134)
        at java.io.FilterInputStream.read(FilterInputStream.java:133)
        at sun.net.www.protocol.http.HttpURLConnection$HttpInputStream.read(Http
URLConnection.java:3335)
        at sun.net.www.protocol.http.HttpURLConnection$HttpInputStream.read(Http
URLConnection.java:3328)
        at org.gradle.wrapper.Download.downloadInternal(Download.java:63)
        at org.gradle.wrapper.Download.download(Download.java:45)
        at org.gradle.wrapper.Install$1.call(Install.java:60)
        at org.gradle.wrapper.Install$1.call(Install.java:47)
        at org.gradle.wrapper.ExclusiveFileAccessManager.access(ExclusiveFileAcc
essManager.java:65)
        ... 3 more

C:\Users\LENOVO2014\myApp\platforms\android\cordova\node_modules\q\q.js:126
                    throw e;
                          ^
Error code 1 for command: cmd with args: /s /c "C:\Users\LENOVO2014\myApp\platfo
rms\android\gradlew cdvBuildDebug -b C:\Users\LENOVO2014\myApp\platforms\android
\build.gradle -Dorg.gradle.daemon=true"
ERROR building one of the platforms: Error: C:\Users\LENOVO2014\myApp\platforms\
android\cordova\build.bat: Command failed with exit code 1
You may not have the required environment or OS to build this project
Error: C:\Users\LENOVO2014\myApp\platforms\android\cordova\build.bat: Command fa
iled with exit code 1
    at ChildProcess.whenDone (C:\Users\LENOVO2014\AppData\Roaming\npm\node_modul
es\cordova\node_modules\cordova-lib\src\cordova\superspawn.js:131:23)
    at ChildProcess.emit (events.js:110:17)
    at maybeClose (child_process.js:1015:16)
    at Process.ChildProcess._handle.onexit (child_process.js:1087:5)

A: If you require to use a proxy on your network then add a gradle.properties file in %USER_HOME%/.gradle with the below but replacing the values with your proxy details. This worked for me.
gradlePropertiesProp=gradlePropertiesValue
sysProp=shouldBeOverWrittenBySysProp
envProjectProp=shouldBeOverWrittenByEnvProp
systemProp.system=systemValue
systemProp.http.proxyHost=myproxy.com
systemProp.http.proxyPort=8080
systemProp.http.nonProxyHosts=\*.mydomain.com|localhost
systemProp.https.proxyHost=myproxy.com
systemProp.https.proxyPort=8080
systemProp.https.nonProxyHosts=\*.mydomain.com|localhost

A: Hi all I had the same issue.
In the platforms\android\cordova\lib\build.js file, I changed
var distributionUrl = 'distributionUrl=http\\://services.gradle.org/distributions/gradle-2.2.1-all.zip';

to
var distributionUrl = 'distributionUrl=http://services.gradle.org/distributions/gradle-2.2.1-all.zip';

and it worked.

A: Since the solution posted above needs to include .zip into folder that is about 55MB
You can also force CLI to use Ant instead of gradle during a build with the following command:
cordova build android -- --ant

A: There seems to be a problem for the previous solutions. At least none of them worked for me, and I just changed it to:
var distributionUrl = 'http://localhost/gradle-2.2.1-all.zip';

Then it works. I don't know why they all add "distributionUrl=" as follows (this doesn't work for me):
 var distributionUrl = 'distributionUrl=http\\://localhost/gradle-2.2.1-all.zip';

BTW, I am using ionic 2.
Pay attention to the path if you don't want to use localhost. It will automatically add myApp/platforms/android/gradle/wrapper before distributionUrl, for example if you put gradle-2.2.1-all.zip in
the myApp/platforms/android/gradle directory, then you need to set:
var distributionUrl = '../gradle-2.2.1-all.zip';

A: Alternatively, if you have a web server on your localhost, download and put the gradle (exactly the tested version, i.e. http://downloads.gradle.org/distributions/gradle-2.2.1-all.zip at the time of this post) in the www root and change the platforms\android\cordova\lib\build.js file in your application directory to this one:
 var distributionUrl = 'distributionUrl=http\\://localhost/gradle-2.2.1-all.zip';

Changing the URL to a local file (not an http address) would not work for me under windows and it would complain that the URL has an unknown protocol.

A: I have faced the same problem recently, and I searched here and there.
Finally for the latest build I found the solution.
After "ionic platform add android" command, go to platforms/android/cordova/lib/builders/GradleBuilder.js
Search for
http\\://services.gradle.org/distributions/gradle-2.2.1-all.zip

and change it to
http\\://downloads.gradle.org/distributions/gradle-2.2.1-all.zip

A: I had the same problem, and it was solved with uninstalling build-tools 24, and installing build-tools 23 from SDK Manager.

A: I ran into this issue as our network proxy is blocking the download of the zip file. Here's what I found:

NOTE: this differs from the "accepted" answer in that we aren't modifying Cordova's library directly. This is far less prone to "error" or being overwritten when you run ionic state restore

*

*Download gradle - http://services.gradle.org/distributions/gradle-2.2.1-all.zip

*Put this file in platforms/android/gradle. However, if you're integrating this into your build process, you may want to stick it somewhere less volatile and add a step to copy the file into that location.

*Set the environment variable CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL to ../gradle-2.2.1-all.zip

*

*linux/osx: add export CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL="../gradle-2.2.1-all.zip" to your ~/.bashrc file

*windows: setx CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL ../gradle-2.2.1-all.zip

*Run ionic build android

A: Another option from command line is to run $ export JAVA_OPTS="-Dhttp.proxyHost=proxy-url.com -Dhttp.proxyPort=911 -Dhttps.proxyHost=secure-proxy-url.com -Dhttps.proxyPort=911"before the cordova build command.

A: I am using Ionic version 1.7.14 and the distributionUrl found in the following file. myApp/platforms/android/cordova/lib/builders/GradleBuilder.js.
I had to point the locally downloaded gradle as specified in this answer.
I had the same problem. I added gradle to my project offline.
After downloading gradle from issued link (here is http://services.gradle.org/distributions/gradle-2.2.1-all.zip) paste it in somewhere likes myApp\platforms\android\gradle\gradle-2.2.1-all.zip and in build.js from myApp\platforms\android\cordova\lib\build.js find this:
var distributionUrl = 'distributionUrl=http\\://services.gradle.org/distributions/gradle-2.2.1-all.zip';

And replace it with your own file's location:
var distributionUrl = 'distributionUrl=../gradle-2.2.1-all.zip';

A: Cordova 6.0.0 / Visual Studio Code 0.10.6
TL;DR
Manually download http://services.gradle.org/distributions/gradle-2.2.1-all.zip.
Place it in appName\platforms\android\gradle\
set CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL=..\gradle-2.2.1-all.zip

Start code and compile.
Explanation:
GradleBuilder.js sets distributionUrl as follows:
var distributionUrl = process.env['CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL'] || 'http\://services.gradle.org/distributions/gradle-2.2.1-all.zip';
Script runs in appName\platforms\android\gradle\wrapper
Output is:
Downloading file://appname/platforms/android/gradle/gradle-2.2.1-all.zip

A: All answers here are all saying the same thing when this could be done easier than the top answer. Updating your Android SDK should fix it, and you can do it with this one line from the terminal:
android update sdk --no-ui --all --filter "extra-android-m2repository"

or
android update sdk --no-ui --filter extra

Also see this repos issue (it's the essentially same problem).
But after you do that rebuild, and it should work.

A: It sounds like Windows Defender or some other antivirus system is messing up with your install. So temporarily deactivate your firewall and re-run the command:
ionic build android (or ios)

At the end you have the message BUILD SUCCESSFUL...

A: As far as ionic development concern,you will have to modified the distributionURL in GradleBuilder.js with below mentioned URL.
/android/cordova/lib/builders/GradleBuilder.js
var distributionUrl = process.env['CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL'] || 'https://services.gradle.org/distributions/gradle-2.14.1-all.zip';

A: I used every thing above but nothing was working  and then I did this and boom it worked..!

Here is what I did:
 1. open cmd from your project
 2. goto https://services.gradle.org/distributions/ click on the version you need , right click and copy link.
 3. Once done set the variable : set CORDOVA_ANDROID_GRADLE_DISTRIBUTION_URL=https://services.gradle.org/distributions/gradle-2.2.1-all.zip
 4. Good to go!

A: Download JDK version 8 and remove all existing versions.
And update Ionic.
I hope your problem will be solved.

A: Updating the Android platform did the trick for me:

*

*Cordova platform update Android

*Cordova prepare,

*Cordova compile and finally

*Cordova build

A: This is because of a Gradle error.
Download the file http://services.gradle.org/distributions/gradle-2.14.1-all.zip and extract it in any of directory and set the path by open cmd and enter: setx path (extracted directory)/bin
After that, reopen cmd and check whether Gradle is works or not by issuing gradle -v. It shows the Gradle version output. Now the error is fixed; run ionic build android.

redpajama_set_name: RedPajamaStackExchange


This spreadsheet allows you to follow the status of requests for the Salón de Actos de la Senieta and Aula de Asociaciones.
After making one or more requests, please allow me some time to organise them.
If, after a day or two, you don't see your request in the list or it has been entered incorrectly, please contact me, so that I can correct the mistake as soon as possible.
The list shows the status of the request, when it was made and, when known, the official (or often informal) response from the ayuntamiento.


text:
Started a Fire
Ghost Town - KJ-52
Doin' Alright
From the middle of nowhere in Indiana, electronic funk-infused pop duo Turnaround began their journey in 2009. Their high-energy shows captivate fans of all ages. Brock Barcus (frontman) and Colton Smith (drummer) are not afraid to write about the heavy things they have experienced in life. Creating honest lyrics based out of their experiences and faith, their music reminds listeners there is always hope. The message from their come-back single is simple, yet powerful—no matter how bad today seems, we can do something monumental: we can change the world for the better, one action at a time.
Brock and Colton both enjoy a wide variety of genres and artists, with influences ranging from the sounds of the Motown era to bands like OneRepublic. In 2017, Turnaround won their regional portion of the Christian Festival Association's National Talent Search at Big Ticket Festival. As a result, the group was invited back in 2018 and played the main stage of Big Ticket, opening for artists Love & The Outcome, Building 429, and Michael W. Smith. The duo had a cameo role in 2017 performing their song "Unforgettable" in the award-winning independent film, Two Steps From Hope by Gaffer Media.
Houston, US6 LISTENERS
Chicago, US5 LISTENERS
Atlanta, US5 LISTENERS
Adelaide, AU4 LISTENERS
Bern, CH4 LISTENERS
Monumental (Acoustic)
Home with You
Lazybones
Positive Music 2021
CROSS NATION
New Christian Music 2021
Top Gospel Internacional
* album inspiration *
Listen to Turnaround now.
Listen to Turnaround in full in the Spotify app


Sinister gray clouds hovered above the Homewood campus early on May 25 and threatened to drench the thousands gathered to participate in and witness the close of the university's 124th academic year.
Luckily for all, these billowy bullies were just show.
The nonprofit sector in Maryland is large and continues to grow, but workers in that sector have few choices when it comes to advanced training in their field. To help fill that void, the university is launching a two-year Certificate in Nonprofit Studies program.


Camden Hardy is a visual artist whose artistic practice is driven by questions about the dissonance that occurs when we encounter information that contradicts our expectations, as well as our own agency in the construction of our individual realities.
In 2010 he founded The Postcard Collective, an international collaborative art project bringing creative minds together through seasonal postcard exchanges. Camden is a Core Faculty member at Southwest University of Visual Arts in Tucson, Arizona.


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This article is part of: Regulatory Science Edition 8
Ton de Boer: Bring Care and Research closer together
"Anyone who uses medicines ought to contribute the knowledge they acquire to help future users. Let's bring Care & Research closer together," says MEB chairman Prof. Dr Ton de Boer. He claims that more research is needed into the favourable effects of medicines. Although this research should be carried out by scientists, input should also be provided by experts from the field or, in other words, the medicine users.
When assessing medicines the MEB always looks at the proof that indicates whether a medicine works, or weighs up the effect against the adverse reactions. "This proof has to be convincing and preferably obtained via standard randomised studies. A lot of thought is going into new types of clinical trials. Some are already being used. In the case of Adaptive Trial Design a study structure based on interim analysis can be adapted, for example by terminating, or indeed increasing, participation by patients with certain characteristics in one or more study arms. We are also seeing Single Arm Trials more and more frequently, for example in conjunction with oncology medication, whereby a pharmaceutical company tries to accelerate the registration of a medicine on the basis of phase 2 studies. However, this is something we at the MEB find very difficult because there is then no control group for a direct comparison."
No 'light assessment'
Ton De Boer recognises that this sounds contradictory. After all, on the one hand the MEB wants to make new medication available to patients quickly while, on the other hand, it puts on the brakes. "Yes because the effect has to be proven and safe. So that requires certain studies and that will always be the case. Patients have to be able to have confidence that, if we authorise a new medicine, the benefit-risk balance is positive. This means that, if possible, large-scale studies are always needed in phase 3. And yes, we're always asked to do it more quickly. And sometimes that's possible. However, there will always have to be convincing proof. That is crucial." He refers to the example of the classical form of Pompe disease, which is a muscular disease that affects children. "In that case the effect of a new medicine called myozyme was so convincing that you just know it's going to work. Because without the medicine you know what the natural progression of the disease is, namely that these children will, on average, die around their first birthday. A control group is then less important when it comes to determining the effectiveness. However, it continues to be a combination of thorough, but also efficient and effective research. Ultimately the proof has to be sufficiently convincing. We don't do any 'light assessment', but we are, however, realistic."
MEB Chairman Ton de Boer
Care & Research
The MEB chairman believes there are opportunities for extra research, once a medicine has been registered and is being prescribed: "As soon as the medicine is registered, we ought to study not only the adverse reactions, but also the favourable effects of medicines systematically and in a valid way."
A type of research which has not yet been used very often, called the Pragmatic Trial, could play an important role, Ton De Boer believes. The idea is that medicines with the same indication are given to patients in a randomised way in everyday practice, for example if you want to compare two statins. The randomisation is arranged via the prescriber and ought to take place in an environment where patients are routinely monitored via 'Electronic Healthcare Records'. This structure enables the favourable effects in the long term to be studied as well and in patient groups which were excluded from the preregistration studies. One problem with this type of studies is the obligatory informed consent in the event of randomisation. Research has shown that the informed consent results in doctors and patients being reluctant to participate. In, among other places, America and Canada a Pragmatic Trial can be carried out in certain circumstances without informed consent. Among other things this is also a case of equipoise, in other words uncertainty on the part of the doctor, patient and researcher regarding the outcome of the study because it entails the comparison of two or more interventions of which the relative benefit-risks of the medicines is unknown. Recently Ton De Boer and other co-authors argued in the BMJ that the regulations should be altered in Europe as well. The Pragmatic Trial can, therefore, bring Care & Research closer together.
Ton De Boer refers to the example of this being done via so-called 'academic GPs', or GPs who cooperate with studies. "The patient knows in advance that his GP is helping with the studies and if the patient does not want to cooperate with a clinical trial, he can indicate this in advance. The following is an example. The doctor establishes that his patient has to start using a cholesterol-lowering medicine, i.e. a statin. You could then carry out a pragmatic study. These days we have a choice of 5 to 6 good quality statins in the Netherlands. So you can have fate determine which statin the patient receives. And if you randomised this data, you can routinely collect information on morbidity and mortality. This will give you an insight into the effects in the long term. That would be a hugely interesting study. After all, everyone gets the care he should get, the patient will be unaware of the study and we will be able to gather a huge amount of knowledge about the relative favourable effects. We will be creating a longer follow up and we can also assess therapy compliance. Although trials do focus on therapy compliance, things are different in everyday practice. What then are the effects? I believe there are enough reasons to collect information on the favourable effects and to study them."
The question is who is going to carry out and finance such studies in the future. The MEB can, in any event, highlight their importance. Ton De Boer thinks that a lot of people realise how important these types of studies are: "And the MEB will then receive a lot more information which is valid and can, if necessary, be used to change the product information relating to a medicine."
Real World Data
Ton De Boer also thinks that this kind of Real World Data could play a much more important role in the pre-registration phase. "In the case of phase 3 clinical studies you could not only carry out studies using data which is collected on the basis of strict protocols, but also data which is routinely collected in the healthcare sector. The patient may, of course, also visit his GP or specialist outside the context of a study if he experiences illnesses and symptoms. The medical data which is then recorded could enrich the clinical study data. Data collected using health apps, such as step counters or heart rate monitors, could be used to monitor the impact of a medicine on, for example, a patient's stamina. There is, however, still some way to go for such data can be used in a meaningful way. We still have to discover how valuable this is. It may well enhance the phase 3 studies, but also be useful thereafter in terms of gaining more of an insight into the favourable effects of medicines." Real World Data can also be used to clarify more effectively the results of the above-mentioned single arm trials in the context of oncology by comparing outcomes with a relevant Real World population.
"It is logical, as regards Real World Data, to look to link up with Health Technology Assessment (HTA) organisations. They too have a clear need for Real World Data to be used via registries."
It is important for the further access and use of Real World Data in the pre-registration phase and thereafter for possible label changes that the MEB cooperates at both national and international level. As Ton De Boer explains, "We are doing that with universities, the National Health Care Institute [Zorginstituut Nederland] (ZIN), the Regulatory Science Network Netherlands (RSNN) and relevant parties within Europe. The MEB fulfils a pioneering role in the EMA Task force on Registries, and also participates in the HMA/EMA – Task force on Big Data. In addition it is important to consider focusing the MEB's scientific policy more on research into Real World Evidence. Cooperation is already taking place with, among others, Utrecht University, Erasmus University Rotterdam and the University of Groningen via PhD programmes in this field."
Ton De Boer believes that the extra information via RWD could further improve patient confidence in medicines. "It is relevant for patients if they know more about their medicines, what the impact is in everyday practice, what they stand to gain and what the adverse reactions are. This will increase confidence even more, even though there is, of course, always the possibility of us discovering that the balance between effectiveness and safety is poorer in everyday practice than we thought during registration."
See also the summary of the 4th RSNN Workshop 2019 – "The future of clinical trials and evidence generation, and their use in regulatory decision making" – where prof. Ton de Boer gave a presentation.
Regulatory Science Edition 8, Tuesday 04 June 2019
Email: science@cbg-meb.nl
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