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Paul Steinle
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Associate Consulting Editors
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I used to cover high school sports in this town, and we had a longtime football coach that even when I went to school he was the football coach – and then when I was covering the sports, I covered his teams and stuff.
We had a good relationship because he knew me and my brothers and everything else. But every once in a while I'd have to take him to task in my column for something but he was never – we'd get to an understanding.
But, he died of a heart attack, which was a bit sudden – he was not that old and seemed to be in good shape and things like that. So I went to the funeral home and the wife was there and their son was there, and he was probably maybe middle school age – 9 or whatever else. And I just expressed how sorry I was. What they told me, they said, you know after he died they went home, and they went through a box of old clippings and things like that. They found a column that I had written when the boy was younger, and I was doing an interview with the coach after they'd lost a football game that night. And how we were discussing the football game and the boy came running up and grabbed his dad, and everything else. And I just put a note in the column about how that sort of made things in perspective.
And they were reading that column to sort of sooth themselves during that time.
Now if that didn't sort of tell me that you can make a difference. It doesn't have to be a law changed or anything else. But in someone's life, you get it down to that level, I thought that made a difference. And I've always remembered that.
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A attention-grabbing and well timed biography of J. Edgar Hoover from a Sibert Medalist.
"King, there's just one factor left so that you can do. you recognize what it really is. . . . You larger take it prior to your filthy, irregular, fraudulent self is bared to the nation."
— and the Bureau — the entire energy he sought after. utilizing photos, cartoons, motion picture posters, and FBI transcripts, Master of Deceit provides readers the mandatory facts to make their very own conclusions. here's a booklet concerning the 20th century that blazes with questions and insights approximately our offerings within the twenty-first.
Maybe most sensible often called the long-suffering spouse of Jackson Pollock, Lee Krasner is now, eventually, being well-known as one of many twentieth century's modernist masters. In Lee Krasner, writer Gail Levin provides us an engrossing biography of the painter—so memorably portrayed within the motion picture Pollack through actor Marcia homosexual Harden, who gained an Academy Award for her performance—a firebrand and trailblazer for women's rights in addition to a superb artist who led a really interesting lifestyles.
Hundreds of thousands of audience recognize and love Bob Saget from his function because the sweetly neurotic father at the spoil hit complete condo, and because the captivating wisecracking host of America's Funniest domestic video clips. after which there are the legions of lovers who cannot get adequate of his scatological, out-of-his-mind stand-up workouts, comedy specials, and outrageously profane performances in such indicates as HBO's Entourage and the hit documentary The Aristocrats.
Within the Beginner's advisor to successful the Nobel Prize, Doherty recounts his not going route to changing into a Nobel Laureate. starting together with his humble origins in Australia, he tells how he constructed an curiosity in immunology and describes his award-winning, influential paintings with Rolf Zinkernagel on T-cells and the character of immune safety.
Joe Louis defended his heavyweight boxing name an unbelievable twenty-five occasions and reigned as international champion for greater than 11 years. He bought extra column inches of newspaper insurance within the Nineteen Thirties than FDR did. His racially and politically charged defeat of Max Schmeling in 1938 made Louis a countrywide hero.
The folks in entrance of the billboard during this picture are lining up for bread after a flood in Louisville, Kentucky. The recognized picture was once taken in 1937 through Margaret BourkeWhite and speaks volumes in regards to the distinction among the all-white, filthy rich, snapshot of the USA and the tough realities of the time. In 1931, for the 1st and basically time in American historical past, extra humans have been leaving the rustic than arriving at its shorelines. Over 100000 of these americans looking higher possibilities utilized to maneuver to Russia within the first 8 months of the 12 months by myself. simply as Marx had expected, staff have been fleeing from the obstacle of capitalism and flocking to the land the place the long run was once being outfitted via their very own palms. while americans arrived in Moscow with their households, they have been filled with optimism. Their childrens went to a different Anglo-American college that used to be stocked with books through authors they knew and loved, resembling Jack London, Mark Twain, and Charles Dickens. Their just a little older brothers shaped baseball groups, which have been so well known that Russians started to absorb the game. The obstacle of Capitalism: The 3rd mystery sixty seven In 1933, for instance, thirteen-year-old Lucy Abolin moved from Boston to Moscow, the place her father took a role as a metalworker. She speedy turned a celeb on the Anglo-American college. Her brothers, Arthur and Carl, performed for the Moscow overseas staff baseball workforce. The Abolins have been a poster family members for the attraction of being americans within the staff' Paradise. HOOVER'S 3rd mystery again in the USA, the Communists have been famously good geared up and fearless, which made them perfect union organizers. within the Thirties, they unfolded to aid staff struggle for his or her rights. no matter if a manufacturing unit hand didn't care approximately Marx or Lenin, he was once joyful to have a robust, powerful voice on his part, arguing for larger wages or shorter hours. Communists driven to arrange car crops, waterfront docks, and Mexican-American and AsianAmerican farmworkers. anywhere there have been americans in desire, american citizens missed, overlooked, or oppressed, the Communists sought them out and provided a assisting hand. as well as its direct assaults on injustice, the Communist celebration sponsored various firms dedicated to solid factors: foster mom and dad for kids stuck up in international wars, the yank adolescence Congress, the Abolish Peonage Committee to struggle for the rights of southern farmworkers. To well-meaning voters, those teams supplied how to aid others, and the truth that the occasion was once in some way concerned with them infrequently mattered. The powerful, energetic organizers mixed with the seeming dying throes of capitalism introduced novices to the get together. club This poster for the yank Communist social gathering was once designed through Hugo Gellert, whose pictures of muscular staff inspired the creators of Superman. Ben Gitlow, named the following as a vice-presidential candidate, labored with John Reed on radical papers and was once arrested in the course of the November 7, 1919, raid Hoover equipped. quadrupled from round 10000 within the mid-1920s to 40 thousand in 1936, then doubled to eighty-two thousand in 1938.


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Home » Destinations » Chhattisgarh » Kawardha
Tour to Kawardha
Kawardha At a Glance
Average Climate:4°C - 20°C
Best Time to Visit:December - February
STD Code:07741
Kawardha is a picturesque little town that is set in the periphery of the Maikal Ranges. This hilly terrain with an altitude of nearly 1000 meters above sea level, lies on the south eastern side of the Kanha National Park which is the largest wildlife reserve in India (in terms of extent). It is for such a strategic situation of the town that Tour to Kawardha is an important content in the itinerary of Chhattisgarh Travel Guide.
Tour to Kawardha, India becomes all the more meaningful due to the scenic beauty of the place. In addition to this, the region in and around the city of Kawardha is characterized by the tribal population which in itself is dominated by the Gond and the Baiga tribes. The forest cover to the south of Jabalpur serves as the home for these tribes. Thus the simple and unproblematic livelihood of the tribes can be closely observed while Touring Kawardha.
Kawardha is also a place that can be marked by a few Monuments and Temples. These sites form the major Tourist Attractions in Kawardha. There are also various places of Sightseeing from Kawardha. These include the following:
The Saroda Reservoir which is an artificial lake situated 12 kilometers from Kawardha
The intricate stone carvings on the temples of Shiva Bhoramdeo belonging to the 11th century A.D. (18 kilometers from Kawardha) form a major place of visit.
The underground rooms of the famous Radha Krishna Temple (belonging to the 19th century) fascinate tourists from all over the world.
For nature, adventure, and wildlife lovers, Sahaspur Wildlife Sanctuary (21 kilometers from Kawardha) is the chief attraction.
Kawardha is easily accessible by rail, road, and air from Raipur, which is the capital of the State of Chhattisgarh. Hence, with all such attractions, Tour to Kawardha is a holiday worth considering.
Things To Do in Chhattisgarh
Kutaghat Dam, Bilaspur
Shivani Temple
Shiva Bhoramdeo Temples
Saroda Reservoir
Ratanpur Fort, Bilaspur
Ram Tekri, Bilaspur
Maria Menhirs
Laxman Temple
Kutumsar Caves and Kailash Gufa Bastar
Akuri Nala
Kailash Nagar Dantewada
Kailash Gufa Jashpur
Holy Places in Mahasamund
Holy Places in Kanker
Holy Places in Bilaspur
Champaran
Bastar Palace
Amrit Dhara Waterfall
About Chhattisgarh
Lakes, Waterfalls & Springs
Rivers and Caves
Tribal Culture
Chhattisgarh Arts and Crafts
Chhattisgarh Tour Packages
Best of Chhattisgarh
India Tribal Tour with Wildlife
Wildlife of MP with Khajuraho
Chhattisgarh and Madhya Pradesh Tribal Tour
Tiger & Tribal Tour
Central India - Royal and Tribal Experience
Top Hotels In Chhattisgarh
Ashish International
Hotel Himalaya Park
Hotel Mayura
Hotel Jaybee Inn Bilaspur
Hotel Grand Amba
Other Cities of Chhattisgarh


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Lok Sabha Elections 2019: The Rahul Gandhi-led Congress is likely to contest between 420 to 430 Lok Sabha seats leaving the remaining seats for its alliance partners.
In pics: Congress president Rahul Gandhi, RJD leader Tejashwi Yadav, DMK president MK Stalin, NCP leader Sharad Pawar and Karnataka Chief Minister and JDS leader HD Kumaraswamy.
Lok Sabha Elections 2019: The elections for the 17th Lok Sabha will take place in seven phases from April 11 to May 19. The result will be declared on May 23. The Lok Sabha has 543 elected members and 91 constituencies will go for polls in the first phase on April 11. Voters in 97 seats will use their franchise in the second phase on April 18 whereas the third phase will be held on April 23 on 115 constituencies. The fourth phase will be held on April 29 (71 seats), fifth phase on May 6 (51 seats), sixth phase on May 12 (59 seats) and seventh phase on May 19 (59 seats). The elections are likely to be a very close contest between the Bharatiya Janata Party (BJP)-led National Democratic Alliance (NDA) and the Congress-led United Progressive Alliance (UPA). The Rahul Gandhi-led Congress is likely to contest between 420 to 430 Lok Sabha seats leaving the remaining seats for its alliance partners. The party has already announced 407 candidates till now and is likely to announce the other candidates soon.
Several parties are contesting under the umbrella of UPA this election. The Dravida Munnetra Kazhagam (DMK) in Tamil Nadu is contesting on 20 seats and the Rashtriya Janata Dal (RJD) has also fielded candidates on 20 constituencies (19 seats in Bihar and 1 seat in Jharkhand). The Nationalist Congress Party (NCP) is contesting on 19 seats in Maharashtra. The Jharkhand Mukti Morcha (JMM) and the Jharkhand Vikas Morcha (JVM) will contest in 4 and 2 seats respectively in Jharkhand. The JMM will contest in 1 seat in Odisha also in an alliance with the Congress. In Bihar, the Rashtriya Lok Samata Party (RLSP), the Hindustani Awam Morcha (HAM), the Vikassheel Insaan Party (VIP) and the Communist Party of India (Marxist–Leninist) will contest on 5, 3, 3 and 1 seats respectively. The other UPA partners are Janata Dal Secular (JDS: 7 seats in Karnataka), Jan Adhikar Party (JAP: 5 seats in Uttar Pradesh), Communist Party of India (CPI: 2 seats in Tamil Nadu and 1 seat in Odisha), Indian Union Muslim League (IUML: 2 seats in Kerala and 1 seat in Tamil Nadu), Apna Dal (Krishna Patel) 2 seats in Uttar Pradesh, Viduthalai Chiruthaigal Katchi (VCK: 2 seats in Tamil Nadu), Communist Party of India Marxist (CPM: 2 seats in Tamil Nadu and 1 seat in Odisha), Swabhimani Paksha (2 seats in Maharashtra), Kerala Congress Mani (KCM: 1 seat in Kerala), Yuva Swabhiman Party (YSP: 1 seat in Maharashtra), Bahujan Vikas Aaghadi (BVA: 1 seat in Maharashtra), Marumalarchi Dravida Munnetra Kazhagam (MDMK: 1 seat in Tamil Nadu), Indhiya Jananayaga Katchi (IJK: 1 seat in Tamil Nadu), Kongunadu Makkal Desia Katchi (KMDK: 1 seat in Tamil Nadu) and Revolutionary Socialist Party (RSP: 1 seat in Kerala). Meanwhile, the party has also decided to back National Conference in Srinagar and in return will get its backing for Jammu and Udhampur seats. The party along with Zoram People's Movement (ZPM) will support Independent candidate Lalnghinglova Hmar in Mizoram. The Grand Old Party has also decided to leave 6 seats (Muzaffarnagar, Baghpat, Mainpuri, Firozabad, Kannauj and Azamgarh) for SP-BSP-RLD grand alliance in Uttar Pradesh.


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Copy numbers, seizures and speech
Posted on July 12, 2012 by Ingo Helbig
Why does this child with speech delay get an EEG? My first encounter with Landau-Kleffner-Syndrome and continuous spikes and waves during slow sleep (CSWS) was in medical school when my pediatric neurology attending faced me with this very question. I looked at him and basically had no idea. This is when I learned about the spectrum of rolandic epilepsies and how epilepsy interacts with speech. This concept is best explained by going back to the most common epilepsy in children, Benign Rolandic Epilepsy (BRE). And the genetics of BRE and the rolandic spectrum has been anything else but straightforward.
Benign Rolandic Epilepsy. The rolandic region is the cortex next to the primary motor and primary sensory cortex and is particularly prone to producing hypersynchronous activity that can be recorded over the centroparietal region. These centrotemporal spikes (CTS) are the hallmark of a group of epilepsies that can be quite heterogeneous. The textbook description is a child that suddenly stands in the parents' bedroom, looks extremely terrified, drools and cannot speak. In some cases, children have a palsy of one side of the body, which might even look like a stroke. Parents are on high alert and rush the child to the hospital. By the time they arrive in the ER, the symptoms are gone. The child receives an EEG on the next day where classical CTS can be seen. This hypothetical case report highlights the major aspects of rolandic epilepsies: they may affect speech, often occur at night and have a particular EEG signature.
Rolandic Epilepsy and twins. Rolandic Epilepsies are self-limiting epilepsies in the majority of cases and the MRI is typically normal. In the genomic era, this suggests that genetic factors could be at play. This is the case with other formerly called "idiopathic" epilepsies including Childhood Absence Epilepsy or Juvenile Myoclonic Epilepsies. In these diseases, twins tell a very clear story: identical twins are almost always concordant, i.e. both twins are affected in contrast to non-identical twins. However, in BRE the story is entirely different. There is not a single identical twin pair reported to date where both twins have typical rolandic epilepsy. They simply don't exist. What twins have in common, however, is the EEG pattern of CTS. On the basis of the familial clustering of CTS, family linkage studies have been performed and these families are also studied within the EuroEPINOMICS CoGIE project. Some candidate genes such as ELP4 for CTS have been suggested.
Epilepsy without seizures – LKS and CSWS. The EEG pattern of CTS is particularly frequent in sleep and can be so frequent that it completely predominates slow-wave sleep. In this case, children have an electrical status epilepticus in sleep. Interestingly, these children often do not have seizures. The term continuous spikes and waves during slow sleep (CSWS) refers to this condition. This status epilepticus, i.e. continuous seizure activity takes its toll on the brain region that is affected the most – the rolandic region, which is important for speech and speech perception. When children are affected to that extent that they loose speech and have difficulties perceiving sounds ("auditory agnosia"), this combination has been described as Landau-Kleffner-Syndrome (LKS). In contrast to "benign" rolandic epilepsy, CSWS and LKS are extremely difficult to treat and are the reason why my attending during medical school wanted to have an EEG done on this particular child (while there is no debate that children with language loss or deterioration should get an EEG, there is actually an ongoing discussion whether this should also be offered to children with primary speech delay, i.e. speech problems from the beginning). CSWS and LKS can be due to lesions or developmental malformations in the rolandic area, but also due to genetic factors.
The genetics of LKS and CSWS. As one of the first genetic findings in the spectrum of benign to severe rolandic epilepsies, SRPX2 was identified in 2006. While the function of SRPX2 as an secreted protein is still unknown and completely unrelated to other pathogenic principles seen in genetic epilepsies, some interaction with the plasminogen activator receptor uPAR has been shown. More recently, the role of copy number variations in CSWS was suggested. In a recent study in Epilepsia, Lesca and collaborators screened a cohort of 61 patients with CSWS and LKS for copy number variations.
CNV analysis is LKS/CSWS. The authors identify 5 bona fide de novo CNVs in 61 patients, a frequency that is comparable to studies in other neurodevelopmental disorders. Many of the other variants identified in this study probably represent benign variants.
CNVs in LKS and CSWS. Lesca and collaborators identify 5/61 (8%) pathogenic de novo CNVs in patients with LKS/CSWS and a large number of previously not identified CNVs that were either inherited or not tested. The frequency of roughly 10% is in line with initial studies on autism, but in comparison to more recent estimated in other neurodevelopmental disorders might be an overestimate. Many genes involved in these de novo CNVs and inherited CNVs have previously been reported in autism studies, which leads the authors to postulate that "genomic dissection makes the link with autism". While it is left to the reader to interpret what genomic dissection actually refers to, some overlap with genes found in autism is surprising. However, some of the genes proposed by the authors might not be as pathogenic as suggested. For example, while intronic and exonic CNVs identified in CTNNA3 are unique and not previously described, other gene-disrupting CNVs can be found in this gene in the Toronto Database of Genomic Variants. Accordingly, this gene is very unlikely to contribute to disease. A similar case holds for other genes identified by the authors, reducing the frequency of 74% of patients with allegedly pathogenic variants to a probably much a smaller number.
Candidate genes in LKS/CSWS. Despite these issues, the confirmed de novo CNVs provide an interesting glimpse into the genetic architecture of LKS/CSWS. One patient was identified with a partial deletion of GRIN2A. GRIN2A, coding for and N-methyl-D-aspartate (NMDA) receptors had previously been identified in rolandiform epilepsies, as well. In addition, deletions in MDGA2 identified in one patient have previously been found in patients with autism. This provides an additional hint that some genetic risk factors including recurrent microdeletions might predispose to a broad variety of neurodevelopmental disorders.
Implications for EuroEPINOMICS. The EuroEPINOMICS-RES consortium has initiated a LKS/CSWS working group and CNV analysis in addition to trio exome sequencing will be performed. Given the initial data from Lesca and colleagues, these investigation might help discover genetic risk factors in a significant fraction of patients with LKS/CSWS, helping us understand these perplexing disorders.
This entry was posted in 2012, Epileptic encephalopathy, EuroEPINOMICS, Papers and tagged CNV, copy number variation, CSWS, genetic architecture, GRIN2A, Landau-Kleffner, microdeletion, SRPX2 by Ingo Helbig. Bookmark the permalink.
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An immigration fugitive from El Salvador wanted for aggravated homicide was deported Thursday by officers with U.S. Immigration and Customs Enforcement's (ICE) Enforcement and Removal Operations (ERO) in Laredo, Texas.
Carlos Vidal Navarro-Montecinos, 22, was flown to El Salvador July 13 on board a charter flight coordinated by ICE's Air Operations (IAO) Unit. Upon arrival, Navarro-Montecinos was turned over to officials from El Salvador's Civilian National Police (PNC).
According to the Attorney General of El Salvador's Department of Usulutan, on March 7, 2015, two MS-13 gang members shot and killed a prominent federal prosecutor, Andres Ernesto Oliva Tejada. Before the shooting, detectives learned that Navarro-Montecinos, an MS-13 gang member, was ordered to scout the location prior to the murder. Navarro-Montecinos is being charged as accomplice to the aggravated homicide. The prosecutor died at the scene from injuries he sustained from the shooting.
On June 9, 2015, Navarro-Montecinos entered the United States near Mission, Texas, and was arrested by agents with U.S. Customs and Border Protection's (CBP) Border Patrol. On Dec. 15, 2016, an immigration judge ordered him removed. On June 8, the Board of Immigration Appeals denied Navarro-Montecinos's appeal. He was transferred to ICE custody and taken to the Rio Grande Detention Center June 11 to await his removal. On June 23, he was transferred to the South Texas Detention Complex in Pearsall, Texas.


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ComicsDC Comics
Harley Quinn: Breaking Glass' Creative Team Opens Up About Reinventing Gotham's Most Dynamic Antihero
Charles Pulliam-Moore
Harley Quinn going for a stroll in her new duds.
Image: Steve Pugh (DC Comics)
Though Batman, Wonder Woman, and Superman would never admit it publicly, Harley Quinn is arguably one of the most important characters in DC's comics, film, and television worlds because of the way she lends herself to a wide variety of reimaginations and deconstructions. More than that, though, Harley's always been a fascinating character who ends up drawing your attention because of the chaotic, exciting energy she brings.
When I spoke with writer Mariko Tamaki and artist Steve Pugh, the creative team behind DC Comics' upcoming young adults graphic novel Harley Quinn: Breaking Glass, they explained how easy and natural it felt to create a new take on the character once they established a few baseline ideas about which parts of her original depiction should be carried over.
Because once you nail down those core elements, everything else that's added only ends up making you realize how dynamic the character's always been, and how much more potential there is to mine from her stories.
DC Universe's Foul-Mouthed Harley Quinn Series Is No Fucking Joke
DC Universe's upcoming Harley Quinn animated series is a show about being confronted with difficult
io9: Who is this Harley Quinn? You can see so much of classic Harley in her, but there's also something that feels distinct about her—it's not just that she's young, she's got this interesting new background.
Mariko Tamaki: We really wanted to make sure that this Harley Quinn was a teenager. Like most heroes, she's had a rough go of life at the start. She lost her dad when she was younger and she has a single mom who's kind of struggled to get by at various points in her life. But really the key element to this Harley is that she's got this incredibly resolute sense of right and wrong, ultimately.
io9: How so?
Tamaki: If she sees you doing something that she thinks is unfair, she's prone to responding the way Harley in Injustice would. She'll take anybody out that she thinks needs to be taken out at any given moment and she doesn't see it as anything other than being fair. She sees it as if she's weighed the scales, made a decision, and feels fundamentally good about the things she does. Even though she doesn't own many things, she has what she needs to get by, and she figures things out. She's never too bent out of shape about anything, and prefers to deal with things as they come at her.
When we meet her here, she's been brought into this new environment where she's got to get herself started again, which is something she's done a lot. She's used to it, but we're meeting her at the beginning of one of the many beginnings of her life.
io9: You really lean into the spacier side of Harley's personality and in the book, but it's clear that she's speaking authentically, and in a really clear-minded way that people just don't understand. Talk to me how you went about finding that voice for Harley.
Tamaki: I really like the idea of Harley being someone who marches to the beat of her own drum, but I wanted to think about what that means exactly for her. She figures things out in a very Harley way, and I pictured that she spent a lot of time by herself growing up and that led to her really having to develop her own own compact worldview in order to survive. It has all these composite parts which are very confusing to other people, but she's not bothered by that, you know? It was really fun to write a character who is so completely at ease with her own weirdness, and not even see herself as being odd. She's just like "Oh, this is how I see things. This is what I need and this is what I feel. And if you steal something from my mom, I'm gonna come and get you because nobody else is gonna do it."
io9: Even though that vibrance in Harley you're talking about puts so many people off, it's what makes Mama so willing to welcome her into his family, and what draws Ivy and the Joker to her as the story progresses, I think. Was your intention always to make Harley, kind of like an emotional lightning rod for the book's other characters?
Tamaki: The idea was to create a sort of triad of characters. Harley's in the middle because she's intensely empathetic to other people and she bonds with and becomes loyal to people very quickly. If you're her friend, she's your friend for life and she's just gonna look after you. Then you have Ivy, who is very socially conscious and very community-minded person who's very connected to the bigger picture of things. And then you have the Joker, who's chaos. The three of them together kind of create, to me, like an interesting reflection on different kinds of justice.
Ivy pointing out how Harley doesn't experience the same kind of radicalized microaggressions she does.
io9: Steve, there an undeniable effervescence to Harley's personality that you totally capture in your illustrations, but the book as a whole has this very intense almost noir vibe to it that really highlights how distinct Harley's way of moving through the world is. Talk to me about how you settled on an aesthetic for this particular story.
Steve Pugh: Gotham became quite a big part of the book for that, for the look of it. I've never lived in America but obviously I've been steeped in that culture since I've had a television. A lot of the area that this is set in was very similar to the place where I grew up, in a small place in Birmingham. That's a lot of small locally owned shops a lot of characters who were just trying to get by, hustling, and keeping things moving. People who had trouble with being forced out of the city because of their rents being raised.
In terms of the characters themselves, I took a lot of cues from Mariko's dialogues almost entirely because she really paints a perfect picture of a human being. You read the dialogue, and it's like a movie—you see the characters, honestly.
io9: It's interesting you say that because yeah, reading the dialogue, these characters immediately read as versions of people that you know, but you've also brought this wildly different style to everyone that sets them apart from their classic comics counterparts.
Pugh: Definitely. These key to reimagining characters, but making them "read" correctly is finding those distinct anchors, and Mariko emphasizes a lot of them. Take the Joker. The purple suit was in the script and I think it's an important visual anchor. I think it's very important—and we learned from The Flintstones—that if you're going to call these people the same name, then you should acknowledge the source material in order to understand where the character's coming from. But that doesn't mean just replicating what we've seen before. There's a certain shape to the Joker. There's a certain theatrical self-obsession that kind of defines his body language. But I also like throwing some random stuff that feels very Joker-y, like he does just like the Nixon two-finger point as he's making his exit.
All the Cozy New Comics Series to Settle in With This Fall
Sure, the planet's on fire more often than not these days, but fall usually means nights drawing…
io9: You're turning his personality into physicality, then.
Pugh: The look of him was kind of defined by who he was in this story. Mariko described him as a creature of media. He's a construct who's put himself together. The plastic bag is...it's sort of like the commercialism and corporate-ness and the cutouts for his eyes, which change every time you see him, are meant to be a ransom note. His entire face is a ransom note made from this collage of magazines.
io9: And for Harley?
Pugh: For Harley, I pictured her as a kid just with lots of layers. She's wearing lots of clothes because she was wearing everything she was carrying with her. When you see her going to school for the first time, she had to carry all this stuff. And I thought "Well, what kind of bag would she have?" She was kind of unprepared for the whole thing, moving. So she had to stuff everything into the pockets of her parka, and every time she moves, you see these big, expansive movements with rulers, and pencils, and pens to jutting out the parka. She's constantly leaving a trail of debris. Those are the kinds of small details I think make you feel like these characters don't just exist on the surface, but they go all the way back.
Harley getting her first inkling that the Joker might not be a good person.
io9: A lot of fans cling very dearly to Harley's classic origin story, but we're going through this interesting period of storytellers rethinking her roots and deciding to just go in a completely different, but still familiar direction. What were the elements of Harley's story that you wanted to elevate in Breaking Glass to really set your spin on the character apart?
Tamaki: The traditional hero's journey is about the obstacles that are placed in front of something. Figuring out what emotional thing is standing in the way of you becoming the kind of hero you want to be. But to me, that doesn't really seem like a good fit for Harley. The question for Harley is more about which direction is she ultimately going to go in. I wanted her story to exist within the larger context of other people's troubles. Harley's problems aren't the only problems that exist at any given point of time and Ivy helps her come to understand that—to give her that perspective. The Joker exists to remind her that she can just destroy things that are bothering her, of course. But Ivy's there to remind her that whatever Harley's going through pales in comparison to what someone else out there is likely going through because everything exists within a larger, imbalanced power structure that hurts people.
io9: Right, and Harley understanding about that imbalance of power really makes it make more sense to steer the character in a different direction than her classic depiction. What value do you think there is in reimagining these characters and developing new incarnations of them?
Tamaki: I mean I think it's always worth interrogating the stories we see as well as the tropes in them. It's worth looking at those stories and seeing who isn't part of these stories or can't be part of those stories. A lot of the sort of original stories reflect the values of the time, or the ideas of the time about various things. I see these things as expansive. How many Batmans are there at any given time? We certainly have no problem with multiple Batmen. Comics is one of the few places where you can say "Look, there's these four versions of these characters who are existing at the same time, and they speak to different things." I don't think it's about obliterating other stories, but being able to have a critical view of a character as a whole, which for me is interesting.
Harley fashioning a new costume for herself.
Harley Quinn: Breaking Glass is on sale now.
io9 Culture Critic and Staff Writer. Cyclops was right.
Angrier Geek
Though Batman, Wonder Woman, and Superman would never admit it publicly, Harley Quinn is arguably one of the most important characters in DC's comics, film, and television worlds because of the way she lends herself to a wide variety of reimaginations and deconstructions.
You can say this about any character not just her. Can a day go by without some one shot or mini-series "re-imagining" one of the big three?


Why the number of blogs is declining? What could be done to reignite the interest in writing?
How can I add a widget to My page?
How to define English user's skill level?
What do you dread/fear about english?
Does changing your avatar reflects a change in your personality? OR the change affects you afterwards?
The journey is always long, hard and trying, but with perseverance, eventually you will get there.
Heart is the greatest cheater in the world. It makes thousands of different excuses to stay in touch with the person you love.
10. IELTS Speaking related blogs..
Special thanks to yasemin and bluerose for the wonderful cards!
Thinking about thinking.. What have I been thinking??
Naveed, thanks for the add... I'm glad. This is for you, cutie bubbles to lift some spirits. Smile.
Kiya haal hain Nave ed? Main tumhari dost manta, mumkin? If you have time, see my blog, Ashura and give us your point of view. Thanks! I hope to be one of your friends.
Hope your way is getting easier and full of success insha allah.


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June Pointer dead at 52
From Sean Dennis@1:18/200 to All on Wed Apr 12 22:39:22 2006
From CNN.COM:
June Pointer, youngest Pointer Sisters, dies at 52
Family said singer had cancer
LOS ANGELES (AP) -- June Pointer, the youngest of the Pointer Sisters -- known for the '70s and '80s hits "I'm So Excited," "Fire" and "Slow Hand" -- has died
of cancer, her family said Wednesday. She was 52.
Pointer died Tuesday at Santa Monica University of California, Los Angeles, Medical Center, the family said in a statement. She had been hospitalized since
late February. The type of cancer wasn't disclosed.
She died "in the arms of her sisters, Ruth and Anita and her brothers, Aaron and Fritz, by her side," the statement said. "Although her sister, Bonnie, was unable to be present, she was with her in spirit."
The four sisters grew up singing in the choir of an Oakland church where their parents were ministers. Bonnie and June formed a singing duo and began performing in clubs around the San Francisco Bay area. Anita and Ruth later joined the group, which sang backup for artists such as Taj Mahal, Boz Scaggs and Elvin Bishop.
Their self-titled debut album was released in 1973, and the song "Yes We Can Can" became their first hit. They followed up with "That's A Plenty," which featured an eclectic mix of musical styles ranging from jazz to country and pop. They won a Grammy Award in 1974 for best country vocal performance by a group for the song "Fairytale."
Bonnie Pointer left the group in 1977 for a solo career.
The Pointer Sisters recorded several more albums, including 1984's "Break Out,"
which won two Grammys for "Automatic" and "Jump (for My Love)." The album's other hit song, "Neutron Dance," was prominently featured in the movie "Beverly
Hills Cop."
June recorded two solo albums, and later left the trio.
Anita and Ruth still perform under the group's name. Ruth's daughter, Issa Pointer, is the trio's newest member.
Funeral arrangements were incomplete.
(That's too bad-she was too young to die. :/ )
--- FleetStreet 1.27.1
* Origin: Outpost BBS - 423.926.0556 - bbs.outpostbbs.net (1:18/200)


text:
""" Django REST Framework Serializers """
from rest_framework import serializers

class CourseGradeSerializer(serializers.Serializer):
    """ Serializer for Courses and their grade policy """
    course_id = serializers.CharField()
    course_display_name = serializers.CharField()
    organization = serializers.CharField()
    run = serializers.CharField()
    name = serializers.CharField()
    course_start = serializers.DateField(allow_null=True)
    course_end = serializers.DateField(allow_null=True)
    course_registration_start = serializers.DateField(allow_null=True)
    course_registration_end = serializers.DateField(allow_null=True)
    grader = serializers.ListField(allow_null=True)
    grade_cutoffs = serializers.DictField(allow_null=True)

redpajama_set_name: RedPajamaGithub


A gene on chromosome 11p15.5 that encodes a voltage-gated potassium channel required for the repolarisation phase of the cardiac action potential. The KCNQ1 gene product can form heteromultimers with two other potassium channel proteins, KCNE1 and KCNE3.
KCNQ1 mutations are associated with hereditary long QT syndrome/Romano-Ward syndrome, Jervell and Lange-Nielsen syndrome and familial atrial fibrillation.


Fans of the bouncy bits will now have something distinctly more human to look at. We presume there will be a few fight scenes as well.
The lovely ladies in Tecmo's multimillion selling Dead or Alive series are bringing their wily ways to the silver screen.
Cory Yuen, director of Jason Statham actioner The Transporter and fight choreographer for Lethal Weapon 4 and Romeo Must Die is currently shooting the flick on location in China and Hong Kong.
The film, which is based on a script co-written by Pretty Woman scribe J.F. Lawton, stars an array of lithe, young Hollywood twentysomethings, including Jaime Pressly (Not Another Teen Movie), pop star Holly Valance, Devon Aoki (Sin City), Matthew Marsden (Black Hawk Down) and Eric Roberts (National Security).
The movie may yet be a way off, but you can catch the ladies in their Xbox 360 debut Dead or Alive 4, which should launch alongside the console at the end of the year.


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Obama haters petition for Colorado to secede: More than 3,000 signatures at WhiteHouse.gov
Sam Levin
| News |
Sam Levin | November 12, 2012 | 9:56am
There's been a lot of talk this election about how divided our country is -- and that was very clear in Colorado, where a roughly even split had two camps bashing each other -- sometimes on opposite sides of the street. Taking the divisiveness to a whole new level, voters angry with the outcome of the election have created a petition to the White House for Colorado to secede from the nation. It has close to 3,000 signatures.
The Colorado petition reads:
Peacefully grant the State of Colorado to withdraw from the United States of America and create its own NEW government.
As the founding fathers of the United States of America made clear in the Declaration of Independence in 1776:
"When in the Course of human events, it becomes necessary for one people to dissolve the political bands which have connected them with another, and to assume among the powers of the earth, the separate and equal station to which the Laws of Nature and of Nature's God entitle them, a decent respect to the opinions of mankind requires that they should declare the causes which impel them to the separation."
"...Governments are instituted among Men, deriving their just powers from the consent of the governed, that whenever any Form of Government becomes destructive of these ends, it is the Right of the People to alter or abolish it, and institute new Government..."
The petition was created on Saturday by Lynette A., of Golden and bears the same text as similar petitions in twenty other states posted on Whitehouse.gov since election day.
As of this writing, Colorado has 3,662 signatures, trailing behind Indiana, Mississippi, Georgia, Kentucky, North Carolina, Alabama, Texas and Louisiana -- all of which created petitions before Colorado.
Still, Colorado has gotten more support than a handful of blue and red states generating similar calls for secession, including New York, South Carolina, Michigan and Tennessee.
Continue to read more about the secession petition. A quick glance through the signatures on Colorado's petition show that many of them are not residents of Colorado. In the most recent thirty at this writing, only three of them are listed as residents of Colorado -- from Pueblo, Littleton and Denver.
The online petitioning platform dictates that the White House must respond if a petition reaches 25,000 signatures within thirty days. That means Colorado is about 14 percent of the way there. Louisiana, which appears to be the first petition created after election day, is currently more than half the way there, with 13,084 signatures.
The petitions, which don't mention Barack Obama or Mitt Romney, come just weeks after both candidates made commitments to bipartisanship and reaching across the aisle in their final pleas for votes.
If voters aren't satisfied with these petitions and still want to make their voices heard beyond the call for secession, there's always a other White House petition entitled "Recount the election!"
More from our Politics archive: "Scott Gessler says he's innocent as Ethics Commission begins investigation"
Follow Sam Levin on Twitter at @SamTLevin. E-mail the author at Sam.Levin@Westword.com.


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St. Paul & The Broken Bones Unveil 30-Date 2022 Tour Including Biggest NYC Show
St. Paul & The Broken Bones Unveil 30-Date 2022 Tour Including Biggest NYC Show Yet At The Beacon Theatre March 11
In Support Of The Alien Coast out January 28 on ATO Records
Watch/Share This Live Performance of Lead Single "The Last Dance": https://www.youtube.com/watch?v=K28c5Ftp0bU
November 9, 2021 – St. Paul & The Broken Bones have announced a lengthy 30-date 2022 US tour to support their forthcoming album and ATO Records debut The Alien Coast, out January 28. The tour features some of the biggest headlining shows yet for the blazing Alabama 8-piece, including a performance at The Beacon Theatre in New York City on March 11. One of the great live bands to emerge over the past few years, St. Paul & The Broken Bones have toured the globe many times over, delivering a "potent live show that knocks audiences on their ass" (Esquire). Led by frontman Paul Janeway, SPATBB have opened for the Rolling Stones and shared the stage with Elton John, and their shows are perennial highlights of marquee music festivals including Coachella and Lollapalooza.
Tickets go on sale Friday morning, see below for the full itinerary.
The band has also revealed a live performance video of lead single "The Last Dance" today. The video captures one of the band's very first live performances of the song and is brimming with their trademark energy and swagger. It was filmed in a single take at Ol Elegante studios in Birmingham, AL, the studio where they made some of their earliest recordings. Watch here: https://www.youtube.com/watch?v=K28c5Ftp0bU
The Alien Coast is a fever dream convergence of soul and psychedelia, stoner metal and funk, and sounds unlike anything they've created before. It is the first SPATBB album tracked in the band's hometown of Birmingham, AL. The arrangement allowed the octet to spend more time and tap a broader creative community than ever before, resulting in their most ambitious work to date. Janeway cites a disparate range of influences that wove their way into the writing for The Alien Coast, from Greek mythology and dystopian sci-fi, to works of art like Bartolomé Bermejo's Saint Michael Triumphs over the Deviland 17th-century Italian sculpture, to colonial-period history books.
The full music video for "The Last Dance" debuted last month and was directed by Machete Bang Bang (Coldplay, Jeff Goldblum, Evan Rachel Wood). Says Janeway: "The juxtaposition of dancing while facing certain doom is what "Last Dance" is all about. Like dancing through a Mad Max scene. So naturally the video had to be a dance video." The band also recently shared the song and video for "3000 AD Mass," a raw, explosive track driven by Janeway's vocal roar that sets the tone for the album.
St. Paul & The Broken Bones has reached incredible heights since breaking out with their first album. Their previous three albums each debuted in the Billboard 200, their legendary NPR Tiny Desk has over 7 million views and they've appeared on several television shows including Jimmy Kimmel Live, Austin City Limits and more. They were the first-ever musical performance on Stephen Colbert's Late Show, were asked to do a rare encore by David Letterman and were nominated for a Daytime Emmy for their appearance on CBS Saturday Morning.
St. Paul & The Broken Bones is Paul Janeway, Jesse Phillips (bass), Browan Lollar (guitar), Kevin Leon (drums), Al Gamble (keyboards), Allen Branstetter (trumpet), Chad Fisher (trombone), and Amari Ansari (saxophone).
https://stpaulandthebrokenbones.com/shows/
Pre-order The Alien Coast: https://atorecords-ffm.com/thealiencoast
St. Paul & The Broken Bones 2021-2022 tour:
December 3 – Athens, GA – Georgia Theatre
December 4 – Columbia, SC – The Senate
December 30 – Nashville, TN – Brooklyn Bowl Nashville
January 26 – Atlanta, GA – Criminal Records (In-store event)
January 27 – Birmingham, AL – Seasick Records (In-store event)
January 28 – Nashville, TN – Grimey's (In-store event)
February 1 – London, United Kingdom – Electric Ballroom
February 3 – Leeds, United Kingdom – Brudenell Social Club
February 4 – Glasgow, Scotland – Old Fruitmarket
February 6 – Paris, Ile-de-France – Bataclan
February 8 – Berlin, Germany – Hole 44
February 9 – Belgium, Brussels – Le Botanique
February 10 – Amsterdam, Netherlands – Paradiso
March 2-March 6 – North Charleston, SC – Riverfront Park Performance Pavilion
Newly announced dates:
March 4 – Atlanta, GA – The Eastern *
March 5 – Charleston, SC – Charleston Wine & Food Festival
March 6 – Raleigh, NC – The Ritz *
March 8 – Washington, DC – Lincoln Theatre *
March 9 – Washington, DC – 9:30 Club *
March 11 – New York, NY – The Beacon Theatre *
March 12 – Lebanon, NH – Lebanon Opera House *
March 13 – Boston, MA – House of Blues *
March 15 – Philadelphia, PA – The Fillmore *
March 16 – Pittsburgh, PA – Stage AE *
March 18 – Toronto, ON – Queen Elizabeth Theatre *
March 19 – Ottawa, ON – Bronson Centre *
March 20 – Detroit, MI – St. Andrews Hall *
March 22 – Chicago, IL – Thalia Hall *
March 25 – Minneapolis, MN – Palace Theatre *
March 26 – St. Louis, MO – The Pageant
April 23 – Dallas, TX – The Granada Theater ^
April 24 – Austin, TX – Stubb's ^
April 26 – Tulsa, OK – Cain's Ballroom ^
April 28 – Denver, CO – Mission Ballroom ^
April 29 – Aspen, CO – Belly Up ^
April 30 – Salt Lake City – Commonwealth Room ^
May 3 – Seattle, WA – The Neptune ^
May 5 – Portland, OR – Crystal Ballroom ^
May 6 – San Francisco, CA/Oakland, CA – Fox Theater ^
May 7 – San Diego, CA – Humphreys Concerts By The Bay ^
May 10 – Los Angeles, CA – The Theatre at Ace Hotel ^
May 11 – Pioneertown, CA – Pappy & Harriet's ^
May 12 – Phoenix, AR – The Van Buren ^
* with Thee Sacred Souls
^ with Danielle Ponder
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text:
Q: looping for a series I have this question:

Write a program to display the sum of the series  1+1/2+2/3+3/4+...
  +(n-1)/n (using for loop).

I did not understand the series well, kindly explaint it for me if n = 6. (no need for coding).

A: For n = 6, you need to calculate 1 + (1/2) + (2/3) + (3/4) + (4/5) + (5/6)

A: The question is asking you to fill the details in to the following program:
sum = 0;
for (int i=1; i<=n; ++i) {
    sum += ???
}
return sum;

where ??? should give you the following values:
i | ???
-------
1 |  1
2 | 1/2
3 | 2/3
4 | 3/4
5 | 4/5
6 | 5/6
.
.
.
n | (n-1)/n

A: It is simple. The biggest hint is the nth term itself : (n-1)/n
Except the first term, every other term can be represented by an expression of the form of (i-1)/i, which means the algorithm boils down to this:
double sum  = 1.0; //first term
for(int i = 2 ; i <= n ; ++i) //2nd to nth term!
   sum += (i-1.0)/i;

Why did I write (i-1.0) instead of (i-1)?
You need to figure that out yourself, as I already have explained and written almost the whole code.

A: Write a loop that evaluates (n-1)/n for each value of n and adds the outcome to some variable.
That "some variable" is the answer.
Set n=6

A: The final term of the series can also be written as n / (n + 1) where n is a value that iterates.

redpajama_set_name: RedPajamaStackExchange


text:
Technical Video Series
Commissioning in the Age of COVID-19
Devesh Nirmul, Managing Director of CounterpointeSRE, joins Wade Conlan and Bill Bradford of Hanson Professional Services for a discussion of commissioning and energy auditing in the age of Covid-19. Listen as they discuss striking a balance between delivering occupant comfort, working towards safety and overcoming financial barriers, each a distinctly different discipline that is adapting to the "new normal."
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Financial and Technical Information
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COVID preparedness
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Pandemic Proof?
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C-PACE Primer
Explore the basics of C-PACE financing, including information on repayment structure, term length and several of the financial highlights.
About CounterpointeSRE:
Counterpointe Sustainable Real Estate (CounterpointeSRE) is a leading commercial real estate finance provider specializing in sustainable infrastructure improvements through PACE financing. Counterpointe Energy Solutions together with its affiliates, including CounterpointeSRE, is engaged in implementing, funding, managing and administering PACE programs and is a program administrator in Chicago, California and Florida.
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text:
Common Side Effects
Prolactin's Effect
Heart Problems and Death
By Emily Miller
Edited By Kevin Connolly
Medically Reviewed by Dr. Ashraf Ali
This page features 9 Cited Research Articles
Risperdal Overview
Lawsuits and Settlements
Lawsuit Information Risperdal lawsuits claim Johnson & Johnson hid serious side effects, including enlarged male breasts. Learn More
Home Risperdal Side Effects
Common side effects of Risperdal include weight gain, drowsiness, dizziness and nausea. Because some side effects such as enlarged breast tissue, obesity, heart problems and diabetes can be serious, experts recommend alternative treatments for children who are stable but experiencing aggression or irritability.
This is an active lawsuit See if you can file
Approved for treatment of schizophrenia, bipolar disorder and autism spectrum disorders, Risperdal (risperidone) caused a host of common side effects in clinical trials, including increased appetite, upper respiratory tract infection, vomiting and rash.
In addition to these, the drug was associated with adverse reactions upon discontinuation. These included dizziness, nausea, irritability, drowsiness (somnolence), abdominal pain, Parkinsonism, restlessness and rapid heart rate.
Although manufacturer Johnson & Johnson has not received FDA approval to market and sell Risperdal for attention deficit hyperactivity disorder (ADHD), sleep disorders, anxiety disorders and depression, doctors prescribe the drug for these "off-label" uses.
According to the package insert, commonly observed adverse reactions in clinical trials included:
Movement disorders (Parkinsonism, tremor, muscle contractions)
Pain in the extremities
These side effects were observed most frequently in clinical trials and range from mild discomfort to severe adverse events that can last indefinitely. Prolonged use of the antipsychotic can lead to tardive dyskinesia and gynecomastia. The latter is a rare side effect that has cost the manufacturer billions of dollars in lawsuits.
In 2005, the FDA required Risperdal and other atypical antipsychotics to carry the agency's strongest warning. The black box was added because of an increased risk of premature deaths of elderly people with dementia-related psychosis.
The warning says the death rate of these patients on the drug during a typical 10-week controlled trial was 4.5 percent, compared to 2.6 percent taking placebos. The causes of death varied. Most involved some type of cardiovascular failure or infection.
"Elderly patients with dementia-related psychosis treated with antipsychotic drugs are at an increased risk of death," the drug's label says.
Researchers examined this warning and published their findings in the Canadian Medical Association Journal in 2007. They found elderly patients on conventional antipsychotic medications face death risks that are comparable or even greater than elderly patients on atypical antipsychotics like Risperdal.
"Until further evidence is available, physicians should consider all antipsychotic medications to be equally risky in elderly patients," researchers said.
Lawsuit Information
Men, boys and their families are suing Johnson & Johnson alleging Risperdal use caused gynecomastia, or enlargement of male breasts that can require surgery to correct.
View Lawsuits
The Effect of Prolactin
Prolactin is a hormone that controls sex drive in males. The pituitary gland produces prolactin, and the neurotransmitter dopamine controls the levels of the hormone.
Risperdal blocks dopamine's action on the pituitary gland and can cause the levels of prolactin to increase and reach abnormal levels.
In women, prolactin stimulates breast development and breast milk production. When high levels of prolactin are present in males, those excessive levels can prompt similar processes, resulting in gynecomastia, excessive breast tissue growth, sometimes accompanied by galactorrhea (abnormal lactation).
In clinical trials involving 1,885 children and adolescents taking Risperdal, 43 boys experienced gynecomastia.
Since the U.S. Food and Drug Administration approved Risperdal in 1993, hundreds of boys have developed breasts that resemble those of women's while on the medication. In some cases, boys' breasts grow as large as "DD" cups.
According to an article published in the Journal of Clinical Psychiatry, elevated prolactin levels may occur in more than 90 percent of Risperdal users at some point during treatment. This effect, referred to as Risperdal-induced hyperprolactinemia, often persists throughout therapy and for some time after the drug is discontinued.
In children and adolescents, the overabundance of prolactin can cause:
Milky, nipple discharge in both males and females (galactorrhea)
Absence of periods in females
Delay in growth
Early Signs of Gynecomastia
Males who take Risperdal not only accumulate fat in their chest tissues, as can happen in overweight boys and men, but they also develop excess breast tissue. Growths typically begin as a small lump under the nipple. The nipple may become tender and gradually will grow larger.
The degree of enlargement can vary from one individual to another, and while gynecomastia most often occurs in both breasts, it can affect just one. When the condition strikes both breasts, each can be affected differently. One breast can grow larger than the other, leaving the patient with an even more uncomfortable social stigma. In some cases of gynecomastia, males produce breast milk.
Treating Gynecomastia
Mild to moderate cases of gynecomastia may resolve themselves with discontinuing the use of Risperdal. Switching to a safer, prolactin-sparing antipsychotic medication becomes an option at that point.
If enlarged breasts remain for a year or more, doctors may suggest surgery to normalize breast size. Many men and boys have had to undergo standard or laser-assisted liposuction, male breast reduction surgery or mastectomy to resolve male breast enlargement.
Risperdal is linked to muscular and neurological problems called extrapyramidal symptoms (EPS). These are uncontrolled movements that involve a series of short, quick movements of the limbs, head and tongue, or slow, painful, twisting movements that are repeated over and over. People may even make involuntary noises such as grunting.
While most antipsychotic drugs come with a higher risk of these disorders, Risperdal and other atypical antipsychotics, the newer generation of antipsychotics, cause fewer cases of EPS.
For some patients who develop these conditions, they remain even after they stop taking the medication.
If a patient notices any loss of motion or control while taking these drugs, a doctor needs to address the problem before it becomes irreversible. Although addressing EPS often involves stopping treatment with antipsychotics, some patients may require continuation of Risperdal despite the presence of movement disorders.
Researchers don't understand why or how antipsychotic medications cause these disorders. Some theories point to the way antipsychotics alter the levels of neurotransmitters like serotonin and dopamine in the brain.
Dopamine is responsible for regulating body movement, and it is possible that by altering dopamine levels, Risperdal can cause unnatural and involuntary movements. This may cause abnormal stimulation of the parts of the brain that signal muscles to move. In many cases, patients will have irreversible damage to receptors in the brain.
Tardive Dyskinesia and Tardive Dystonia
Tardive dyskinesia and the related tardive dystonia are two conditions that involve abnormal bodily movements. The risks of developing them and the likelihood they will become irreversible are believed to increase as the duration of treatment and the dose administered increase. There is no known treatment for established cases of tardive dyskinesia, although doctors may recommend discontinuing use of Risperdal in an attempt to lessen or stop symptoms completely.
In clinical trials, parkinsonism was listed as one of the most common adverse reactions to Risperdal in schizophrenia patients. When caused by a medicine, it is also referred to as secondary parkinsonism. This helps differentiate the condition from Parkinson's disease.
Like tardive dyskinesia and dystonia, parkinsonism causes involuntary body movements. Elderly users are most susceptible.
Weight gain is one of the most common side effects of Risperdal. In one study, patients gained an average of 4.6 pounds after 10 weeks of treatment. The FDA reports that patients on the drug had "a statistically significantly greater incidence of weight gain."
Patients who experience any side effects while taking this drug should contact their doctors. They should not stop taking any medication without consulting a doctor, as this may result in withdrawal and a relapse of symptoms.
Risperdal can cause the pituitary gland to grow in size. This disrupts the production of hormones and can lead to the development of pituitary tumors.
One study published in the journal Pharmacotherapy analyzed the FDA's adverse effect database and found that the drug accounted for 70 percent of all pituitary tumors. The researchers also said that there may be more cases but the adverse events are underreported.
While pituitary tumors are usually benign, they can cause other serious health problems, such as vision problems, internal bleeding, headaches and convulsions.
Risperdal can cause the pituitary gland to increase in size leading to pituitary tumors.
Patients with schizophrenia are already at an increased risk of diabetes mellitus (Type 2 diabetes) compared with the general population. On top of this, studies suggest a relationship between antipsychotic use and high blood sugar incidents, known as hyperglycemia-related events. Patients on any antipsychotic should monitor their glucose levels.
Risperdal is associated with elevated blood sugar levels and diagnoses of Type 2 diabetes, including, in rare cases, extreme ketoacidosis (shortage of insulin) resulting in coma or death. Studies suggest that the risk of Type 2 diabetes is higher with atypical antipsychotics than with traditional antipsychotics.
More than 13,000 Risperdal lawsuits have been filed against Johnson & Johnson. Learn about pending cases.
Numerous studies show Risperdal and other atypical antipsychotic drugs can interfere with the electrical impulses that regulate heart rhythm, causing cardiac arrhythmias that can lead to cardiac arrest and death.
Another rare but serious side effect is neuroleptic malignant syndrome (NMS), a life-threatening neurological condition that occurs in less than 1 percent of patients taking an antipsychotic medication.
In a 2009 study published in the New England Journal of Medicine, researchers found that users of atypical antipsychotic drugs had a rate of sudden cardiac death that was more than twice the rate for nonusers.
Arrhythmia (Irregular Heartbeat)
All antipsychotic drugs are associated with increased risk of arrhythmia, or irregular heartbeat.
A 2002 study evaluated risk of arrhythmia and cardiac arrest in schizophrenic patients treated with risperidone, clozapine, thioridazine or haloperidol between 1993 and 1996. According to the study, patients using these drugs had rates of arrhythmia and cardiac arrest between 1.7 and 3.2 times higher than that of a control group (even though members of that control group were older than the patients taking antipsychotic drugs). Death rates also were higher — 2.6 and 5.8 times higher.
Of the four drugs evaluated, Risperdal had the highest risk of cardiac arrest, arrhythmia and death, and surprisingly, that risk increased with lower doses of the drug.
Other heart issues associated with Risperdal include metabolic changes that can increase the risk of disease, such as hyperglycemia, diabetes, dyslipidemia and weight gain.
Previous Topic Lawsuits and Settlements
Next Topic Risperdal
Risperdal Plaintiffs Get OK to Seek Punitive Damages
Court Reverses $5.6M Risperdal Death Case Verdict
Written By Emily Miller Managing Editor
Emily Miller is an award-winning journalist with 7 years of professional experience writing and editing content for reputable media organizations across the U.S. She also has 13 years of personal experience as a patient living with Crohn's disease. Her coverage of U.S. prescription drug prices for Drugwatch has been published or cited by news outlets, including The Hill, Fox Business and United Press International. Some of her qualifications include:
Society of Professional Journalists and The Alliance of Professional Health Advocates member
Centers for Disease Control and Prevention Health Literacy certificates
2016 Florida Society of News Editors third place winner in Breaking News
Kevin Connolly Editor
Dr. Ashraf Ali Psychiatrist
Duke Medicine News and Communications. (2006). Antipsychotic drug may be linked to pituitary. Retrieved from https://corporate.dukehealth.org/
Gandey, A. (2006, June 3). Antipsychotic drugs linked to pituitary tumors. Retrieved from https://www.medscape.com/viewarticle/533771
National Institutes of Health. (2013). Gynecomastia. Retrieved from https://medlineplus.gov/ency/article/003165.htm
National Institutes of Health. (2010). Risperdal (risperidone). Retrieved from https://dailymed.nlm.nih.gov/dailymed/index.cfm
New Zealand Medicines and Medical Devices Safety Authority. (2001). Hyperprolactinaemia with antipsychotics. Retrieved from https://www.medsafe.govt.nz/profs/puarticles/hyperpro.htm
Rosenbloom, A. L. (2010). Hyperprolactinemia with antipsychotic drugs in children and adolescents. Retrieved from https://www.ncbi.nlm.nih.gov/pmc/articles/PMC2943074/
Schneeweiss, S. et al. (2007, February 27). Risk of death associated with the use of conventional versus atypical antipsychotic drugs among elderly patients. Retrieved from https://www.cmaj.ca/content/cmaj/176/5/627.full.pdf
Silverman, E. (2012, September 11). J&J Sees Male Breasts And Quickly Settles Risperdal Suit. Retrieved from https://www.forbes.com/sites/edsilverman/2012/09/11/jj-sees-male-breasts-and-quickly-settles-risperdal-suit/
U.S Food and Drug Administration. (2012). 2012 Meeting Materials, Pediatric Advisory Committee to the Food and Drug Administration. Retrieved from: https://wayback.archive-it.org/7993/20170405191807/https://www.fda.gov/AdvisoryCommittees/CommitteesMeetingMaterials/PediatricAdvisoryCommittee/ucm283814.htm
Side effects from Risperdal use?
Call now for a free case review


Welcome to Happily Ever Parties of Nebraksa!
Please fill out the CONTACT FORM if you would like to book an event, or send an email.
Prices listed are for parties that are physically located in or near the Chicago area. Extra costs for mileage may apply, for parties that are outside of this area.
2 Characters - 30 Minute Meet & Greet - $250 Total plus tips. $150 down payment/booking deposit plus $50 in cash to each character, ($100 cash total) at the event. Tips appreciated. (No supplies or activities are included, Character just drops by & interacts with the kids, poses for photos & etc.
1 Character for 1 hour $150 total plus tips. $100 down payment/booking deposit plus $50 in cash to character at event. Tips appreciated. (45 minutes is the same rate as 1 hour).
1 Character for 1-1/2 hours $175 total plus tips. $100 down payment/booking deposit plus $75 in cash to character at event. Tips appreciated.
1 Character 2 hours $200 total plus tips. $100 down payment/booking deposit plus $100 in cash to character at event. Tips appreciated.
1 Character for 2-1/2 hours $225 total plus tips. $100 down payment/booking deposit plus $125 in cash to character at event. Tips appreciated.
1 Character for 3 hours $275 total plus tips. $125 down payment/booking deposit plus $150in cash to character at events. Tips appreciated.
Your costume character visit of 1 hour or more can include your choice(s) of some of these activities (as time permits): Light face painting, simple balloon twisting, temporary tattoos, reading a story book, a princess singalong, dancing, limbo game, and/or light age-appropriate make-up.
The activities that can fit into your event will depend on the length of time you have booked your character and the number of children at the party. Please note that light face painting takes approximately 5 minutes, per face; plan accordingly.
There may be additional charges for supplies, if there are more than 50 children at your event.
has experience acting for theater and film. She is a teacher and an experienced princess entertainer.
Why Choose Happily Ever Parties & Entertainment?
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evennia.prototypes.menus
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.. automodule:: evennia.prototypes.menus
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It costs truckers HOW much to sit in Jersey traffic?
ARLINGTON, Va. — According to a report released Tuesday, the worst-in-the-nation congestion of the New York-New Jersey metropolitan area causes the trucking industry to lose $3 billion a year in the Garden State alone, accounting for nearly 5 percent of congestion costs nationwide.
Even given the notorious Jersey bottlenecks like the Routes 95/4 approach to the George Washington Bridge, New Jersey ranked only fifth in the study done by the American Transportation Research Institute, a division of the American Trucking Association, as reported by NJ.com. New York was fourth, at $3.9 billion lost by truckers in the year 2015; Florida led all states at $5.3 billion.
Across the country, truck drivers lost $63.4 billion in 2015 while stuck in a combined 996 million hours of traffic on major U.S. roads. That would be the equivalent of 362,000 drivers sitting in their individual cars and not moving for an entire year, the report said.
Even though several factors in New Jersey are helping to improve the situation — such as the recent 23-cent-per-gallon hike in the gas tax and the widening of the New Jersey Turnpike past Exit 6 — the lost costs represent not just wasted time, according to the report, but wasted fuel, shipping complications, and wear-and-tear on the trucks themselves.
Source: It Costs Truckers HOW Much To Sit In Jersey Traffic?


text:
Italy moves against corruption with "bribe destroyer" bill
By: Reuters
Fri, Sep. 7, 2018
ROME - 7 September 2018: Italy's government on Thursday moved to prevent people convicted of serious corruption from ever working with the state again with a bill it says will save billions of euros.
The so-called "bribe destroyer" or "spazzacorrotti" bill is a brainchild of the anti-establishment 5-Star Movement, which took office after campaigning against the rampant corruption that has characterised Italian politics in the past.
Five-star has governed in a coalition with the far-right League party since June.
Deputy Prime Minister Luigi Di Maio, who is also 5-Star leader, told reporters the bill would save the state "billions" of euros. He did not specify how that figure had been calculated.
Justice Minister Alfonso Bonafede, also 5-Star member, hailed the bill as a "revolution in the fight against corruption," after the cabinet approved it.
"This is the first in a series of measures that should make the country competitive again," Prime Minister Giuseppe Conte said.
The bill now goes to parliament. The coalition has a majority in both houses, but Italian legislation is often amended by deputies before becoming law.
Under the government's draft, anyone convicted of corruption and sentenced to more than two years in prison will never be able to hold public office or seek a state contract again, Bonafede said.
Those convicted of corruption crimes carrying sentences of less than two years will be shut out of public business for five to seven years, he said.
The legislation would also allow undercover agents to work on corruption investigations for the first time.
Another component of the bill is that it will require full transparency on private and corporate contributions to political parties and foundations, Di Maio said.
"This will allow us to finally understand why over the years we've seen some policy choices made that went against the interests of citizens," he said.
Egypt, UAE, US, France, UK, Italy urge de-escalation, warn terrorists
Tue, Jul. 16, 2019
Italian farmers oppose EU-Mercosur trade deal: Italy's agriculture minister
Egypt keen on maintaining strong relations with Italy: governor
Mon, Jul. 15, 2019
South Africa's Zuma to face corruption inquiry
6 arrested for attempting to sell state land at fraction of price
Maat Foundation delegates to attend 41st UNHRC Session
Sun, Jun. 23, 2019
Italy's deputy PM praises Egypt's efforts in investigating Regeni's death
Wed, Aug. 29, 2018
Italy's deputy PM expresses keenness to boost partnership with Egypt
Tue, Aug. 28, 2018