text:
Genomic transformation in UK pathology
Bulletin April 2016 Number 174
This article by Dr Isabelle Delon and Dr Mike Scott of Cambridge University Hospitals NHS Foundation Trust discusses the clinical applications, challenges and workforce adaptation in the field of genomics.
What is genomics: Techniques and costs
Genomics is a genetic discipline concerned with mapping, analysing, modifying and interrogating the whole genome of an organism. It considers the entire set of genes and their functions within their structural landscape and surrounding non-coding sequences. Given the large size of genomes, genomics is frequently concerned with broad questions and uses large datasets and statistical methods to find patterns and come to high-level conclusions. However, it also examines and compares single individual genomes to identify differences and rare events. Functional genomics in turn looks at the function of genes in different contexts and tries to integrate datasets such as DNA sequence (genome), DNA methylation (methylome), gene transcription (transcriptome) and protein expression (proteome) to understand cellular or tissue function.
The field of genomics has witnessed an explosion in interest in the last ten years due to the rapid advances in sequencing technologies. Generating the data is no longer a limitation; it is fast and becoming cheaper day by day. From 2008, with the introduction of next generation sequencing (NGS), the cost of re-sequencing of a human-size genome dropped from $1 million to $1000 according to NIH monitoring figures.1 Costs including laboratory activity to produce the sequence have been driven down by the intense competition between sequencing technology companies, to the great benefit of the wider scientific community.2 Bioinformatic algorithms concerned with the alignment, mapping and filtering sequencing data as well as variant calling and variant annotation have advanced rapidly to accommodate this dramatic increase in activity. As a result, both commercial and public bioinformatic pipelines have become highly sophisticated and capable of producing high-quality, reliable data. Of particular relevance to the study of genetic variation, although manufacturers provide pre-made tools for the analysis of VCF files (variant call format, a file containing the variations against a reference sequence), custom scripts are often favoured in order to tailor pipelines to the specific analytical or clinical requirement. However, interpretation of such data with regards to their clinical significance is lagging behind and will require systematic efforts to help it advance.
Clinical applications of genomics: promises and risks
Translational research has seen application of genomics in an increasing number of clinical fields, from the diagnosis or monitoring of disease to the development, choice or stratification of therapies. However, translating the use of genomics into the clinic is a daunting business because of the wide uncertainties implicit to large and complex datasets. Constitutional genetics is already benefiting from whole genome (WGS) or whole exome sequencing (WES). With the possibility to interrogate the genome of an individual on a large scale has come the immense hope for the end of the diagnostic odyssey for people or families with rare genetic disorders. But while the possibilities are immense, the risks are also great: What will be the implication for the patient and their family if we see something we didn't look for, so-called 'incidental findings'? How will the patients and their doctors deal with uncertainty when there is no clear-cut answer? A genetic result can help the choice of therapy, but it can equally generate concern and anxiety. These are highly pertinent questions that render the task of translating genomic data into clinical advice complex and sensitive.3 The ultimate goal of genomic data interpretation in rare disease diagnosis is to spot the critical difference, or find the rare event in the whole of the genome that is sufficiently deleterious to cause disease.
As with inherited diseases, genomics has become an important tool for the diagnosis and management of acquired disorders. Large international efforts such as the Cancer Genome Atlas, for example (TCGA4), have led to the identification of recurrent somatic mutations that drive oncogenesis in a wide variety of cancers, through the comparative sequencing of cancer and constitutional genomes.5 These advances have truly revolutionised both the understanding of the molecular pathogenesis of cancer as well as cancer diagnosis, classification and monitoring.
Another important area of progress is targeted cancer therapy and pharmacogenomics, which are already in use as personalised medicine tools. Amongst the most used are HER2 in breast cancer (trastuzumab), KRAS/NRAS in colorectal cancer (cetuximab and panitumumab), EGFR and ALK in non-small cell lung cancer (gefitinib/erlotinib and crizotinib), BRAF in melanoma (vemurafenib) and chronic myelogenous leukaemia (imatinib). So far, approximately 50 targeted drugs have acquired regulatory approval to treat nearly three dozen types of solid tumours and haematological malignancies (www.centerwatch.com/drug-information/fda-approved-drugs). Many of the targeted therapies are approved along with a specific molecular test or companion diagnostic kit, making the precision molecular diagnostics a mandatory prerequisite for the cost-effective use of targeted treatment. With the wider availability of tumour sequencing, more of these tests, or combinations thereof, could be developed to improve and personalise treatment further. However, although screening and diagnostic tests are already possible, the pharmacogenomics field is complicated due to high complexity of the cancer genomes and the average ten-year period for drug development. A recent report by Mody et al (2015) describe the clinical utility of combined germline exome sequencing with DNA and RNA sequencing of tumour in paediatric cases. The study set out to identify actionable germline mutations and somatic mutations that may modulate the histopathology diagnosis and be amenable to specific drugs. The study reports 46% of cases with actionable results, half of those translating into a change of management including therapy. The authors stress that unfortunately targeted therapy was often unavailable. Commenting on this study, Schnepp et al (2015) highlight the importance of the multidisciplinary board for the interpretation of the data but also reflects on practicality and best use of cancer genomics:
"Although comprehensive sequencing is clearly optimal for discovery efforts, gene panel NGS strategies that provide robust depth of coverage (necessary to detect potentially important subclonal events) and that can now be manufactured to cover the majority of known gene-fusion events have significant advantages as a companion diagnostic when the goal of the assay is to promptly assign therapy because results generally can be returned in less than 2 weeks. There is clearly no single best technology, and the field will likely adapt a hybrid approach to address practical, clinical, and financial pressures."
The integration of genomics in cancer diagnosis practice is therefore still underway and may involve a phased adaptation to technology first – transferring all molecular testing to gene panels and NGS sequencing – and then the introduction of blood/tumour WGS when interpretation is deemed feasible.
The third main area of genomics in medicine concerns microbiology and virology and their role in infectious diseases diagnostics and public health surveillance. Sequencing of pathogen genomes can be used to discriminate between species with high confidence, while informing about features such as virulence, resistance and phylogeny. Pathogen sequence information can therefore be used for rapid diagnosis and treatment and transfusion safety, as well as monitoring data for outbreak protection and guideline for drug uses. The recent national strategic review by the PHG Foundation enounced important recommendations for the implementation of 'pathogen genomics'.8 The report discusses how current practice is limited to outbreak detection and control, for example reporting of a MRSA outbreak within the neonatal unit at Addenbrooke's Hospital.9 The PHG Foundation proposes a framework for the development of integrated and nationally coordinated diagnostic pathogen genomics based on the concerted development of a strategic capacity and integration of knowledge and data. As in rare diseases, genomics of infectious diseases has the potential to halt the diagnostic odyssey, with the added complexity of obligatory rapid turnaround. Integrated testing is being developed on a research basis, for example the UCSF's precision medicine test for infection,10 using a microarray and massively parallel deep sequencing approach to comprehensively identify infectious agents in blood. Therefore with its resolution power combined with capacity to improve the laboratory workflow, pathogen genomics is a very promising innovation in the diagnostic and management of infectious disease.
Genomics in the UK NHS
Large projects, such as the 100,000 Genomes Project led by Genomics England and in partnership with sequencing industries, lead the way. In the UK, the structural organisation into genomic medicine centres will play a critical role in the future to channel results and ensure the legacy of the 100,000 Genomes Project. Focusing on rare diseases, cancer and infectious diseases, the project embraces the three main branches of genomics as described above. The proposed infrastructure will bring together clinicians, diagnostic laboratories and research units into 'clinical interpretation partnerships', therefore building bridges across disciplines and accelerating translational research into clinical utility. Genomics England says:
"For patients with rare diseases, we hope to help with diagnoses, for cancer patients we hope the programme will help to target medicines more appropriately and for infectious diseases it may help to generate new opportunities for therapies for these diseases".
Translational genomics research is, of course, not restricted to the Genomics England initiative and many applications of genomics are being developed in partnership with industry.
Genomics thus carries huge opportunities to improve clinical practice in many fields across pathology. Quicker, cheaper, more practical and more easily integrated practice, genomics will drive improvement in patient pathways. As the invention of the x-ray at the end of the 19th century drove a revolution in medical imaging,11 rapidly improving technological advances are driving the field of genomics. Harnessing the novel opportunities brought by genomics while maintaining patient safety and integrating novel ways within traditional pathology is a major challenge that the NHS must approach. Training the current workforce and educating future ones across scientific, medical and other healthcare professional disciplines seems like a gargantuan task. However, a combination of policy, education and training programmes is shaping the current top-down approach to change.
Challenges to the current workforce
The bottleneck to genomics approaches is no longer technical; it resides in the interpretation of data. It is not easy and remains very time consuming. The main challenge for the current workforce is that somehow we first have to 'unlearn' in order to learn new ways. From a rare disease point of view, screening a gene will result in a 'yes' or 'no' answer within the limit of the given analysis, whereas the interpretation of a whole genome is based on the relative frequency of an event compared to control populations and in the context of a specific disease. This requires appropriate filtering of data and balanced judgement using multi-source information.
This heuristic approach contrasts sharply with the more or less binary evaluation that prevails in traditional genetic testing. Fear for the increase of uncertainty and the decrease in quality fuel resistance to change. Somehow we have to reframe our expectations. Partly, this may be a matter of solving the 'excellent being the enemy of the good' and moving through the shift in paradigm that will drive the democratisation of genomics.12 Genetic testing will not just be required within a genetics clinics, but will be integral to any clinic where a genetic aetiology of the disease is suspected.13,14 This is already happening, and it can disturb the social order and lead to confusion by blurring boundaries. Building bridges across disciplines will enable the current genetics workforce, pathologists in general and other medical disciplines to embrace genomics and make the most of it for the great benefit of our patients. Moreover, the risk of misdiagnosis and uncertainty can be greatly reduced by the setting of rigorous quality measures of the raw data and processes of interpretation using evidence-based sources and scientific expertise15.
Genomics transformation: policy, education and training
The 5 Year Forward View for the NHS (2014)16 identifies technological advances and its ability to transform the way we predict, diagnose and treat disease as a fundamental challenge for the health system. Accelerating useful health innovation via translational research to promote advances in the diagnostic setting is a top priority. In that respect, the 100,000 Genomes Project is a major flagship project for the NHS. The Accelerated Access Review17 discusses further factors that have been impeding translation of innovation in clinical practice, especially in the precision medicine field, one of the key applications of genomics. Supporting a modern workforce in collaboration with Health Education England (HEE) is recognised in the 5 Year Forward View as a necessity to bring about new care models, innovation and working across boundaries. In a report commissioned by the Office of Life Science,18 shortage of skills in bioinformatics and genomics is recognised as a key constraint for the evolution of the sector, the major challenge being data analysis and interpretation.
The HEE framework 15 (2014–2029)19 places emphasis on genomics as a driver for innovation and recognises the need to invest in appropriate training of both existing and future workforce to ensure the legacy of the 100,000 Genomes Project and the successful integration of genomics into mainstream care pathways. With this in mind, £25 million has been allocated to support genomics education and the workforce transformation project. The objective of the transformation project is to educate the entire healthcare workforce, including commissioners and GPs. The HEE transformation programme includes training across a large proportion of the workforce via targeted programmes and the recruitment of new cohorts of scientists in new disciplines that will support the development of genomics in practice. The ultimate goal is to create an intersection of skills for better working across boundaries between clinical scientists, pathologists, clinicians, industry and academia. A comprehensive program of education includes:
• the commissioning of new scientist training programmes (STP) in molecular pathology, genomics and genetic counselling and bioinformatics. The National School of Healthcare Science, part of HEE since 2013, provides the structure for the STP training
• HEE-sponsored higher specialist scientist training (HSST) posts have been filled in genetics and molecular pathology, in order to produce consultant clinical scientists in these areas
• the introduction of a sponsored MSc in genomic medicine offered by several universities and available to current staff on a part-time basis, including the option to subscribe to individual modules as CPD units. In addition, online courses and resources are offered on the Genomics education website20
• the encouragement of translational research stemming from the 100,000 Genomes Project via research fellowships for PhD students and post-doctoral scientists
• raising the awareness of genomic medicine by non-specialist staff.
This College has a major role to play in training. An approved curriculum is now available in molecular pathology and examinations leading to Fellowship are in development. The first Part 1 examination will have taken place by the time this article is published. Successful completion of the curriculum is an integral component of the five-year HSST programme. A HSST clinical bioinformatics curriculum is under development.
Regulation and monitoring of outcomes are overseen by the Association of Clinical Scientists and the Academy for Healthcare Science, both providing standards and regulations for the recommendation of trainees to the Health and Care Professions Council (HCPC).
In parallel to the scientific workforce transformation, the integration of genomics into clinical practice will also require evolution of medical training. Aspects of this are covered in the article elsewhere in this issue by Dr Young.
The genomics movement
In addition to generating policy and new education programmes, the genomics movement will need enthusiasts and tempered radicals to ensure continuity and commitment to the organisational change required to fully integrate genomics into practice. Clinical geneticists organising their own future as interpreters and researchers highlights the need to break boundaries between the medical and scientific workforce. As the emphasis of our role turns towards the analysis of large datasets, increased joined practice and co-leadership with pathologists, medical geneticists, scientists and other specialties are necessary to make clinical interpretations while developing safe practices and monitoring outcomes.15 The concept of the multidisciplinary team (MDT) as a cross-boundary vehicle for progress needs to shift to the centre of a new work organisation3 and inevitably MDT collaboration and distributed leadership will emerge as the new ethical values in medicine.21 Innovative thinking will come from the establishment of novel relationships across traditional boundaries.22 In turn, we will become more versatile in our intellectual aptitude to integrate information and stimulate new critical thinking.
Building this strategic capacity will enhance our ability to play an important role in designing the practical delivery of genomics in the clinic. The supporting structures of the nascent Genomic Medicine Centres (GMCs) and their parent, Genomics England, have been founded to nurture the genomics transformation. GMCs provide the opportunity to change the organisational landscape and build a new collective identity amongst healthcare professionals. Being part of the foundation of the genomics movement enables participants to drive policy in that area, activity that has always been an integral role of healthcare scientists.23 In addition to the clinical utility of WGS, the study of practicality and cost-effectiveness for laboratory routine and patient pathways is a topic that will necessarily drive changes in policy at high level. Organisational change is a critical step for the genomics transformation, although the relationship between 'biotech revolution' and policy-making needs is not always obvious and needs caution.24 The genomics transformation is a large-scale change for medicine, entailing a relatively quick shake-up of culture and values in GMCs in order to sustain the growing demands and make the most of the possibilities.
Genomics is the story of us and the story of now. Investment in training will certainly help promote new values but professionals must also drive the movement from within.
Dr Isabelle Delon
Clinical Scientist in Molecular Genetics (HSST trainee)
Dr Mike Scott
Clinical Lead
Haematopathology and Oncology Diagnostic Service
1. National Human Genome Research Institute. DNA Sequencing costs. www.genome.gov/sequencingcosts (accessed 29 February 2016).
2. Mardis ER. A decade's perspective on DNA sequencing technology. Nature 2011;470:198-203. doi:10.1038/nature09796.
3. Bowdin SC, Hayeems RZ, Monfared N, Cohn RD, Meyn MS. The SickKids Genome Clinic: Developing and evaluating a pediatric model for individualized genomic medicine. Clin Genet 2015;89:10–19. doi:10.1111/cge.12579.
4. National Human Genome Research Institute. The Cancer Genome Atlas. www.cancergenome.nih.gov (accessed 29 February 2016).
5. Kandoth C, McLellan MD, Vandin F et al. Mutational landscape and significance across 12 major cancer types. Nature 2013;502:333–339. doi:10.1038/nature12634.
6. Mody RJ, Wu Y-M, Lonigro RJ et al. Integrative clinical sequencing in the management of refractory or relapsed cancer in youth. JAMA 2015;314:913–925. doi:10.1001/jama.2015.10080.
7. Schnepp RW, Bosse KR, Maris JM. Improving Patient outcomes with cancer genomics: unique opportunities and challenges in pediatric oncology. JAMA 2015;314:881–883. doi:10.1001/jama.2015.9794.
8. Luheshi L, Raza S, Moorthie S et al. PHG Foundation. Pathogen Genomics Into Practice, 2015. www.phgfoundation.org/reports/16857 (accessed 29 February 2016). ISBN 978 1 90719 818 2.
9. Harris SR, Cartwright EJP, Török ME et al. Whole-genome sequencing for analysis of an outbreak of methicillin-resistant Staphylococcus aureus: a descriptive study. Lancet Infect Dis 2013;13:130–136. doi:10.1016/S1473-3099(12)70268-2.
10. Chiu C, Global Research Projects. Broad Detection of infectious agents in blood by microarrays and deep sequencing. http://globalprojects.ucsf.edu/project/broad-detection-infectious-agents-blood-microarrays-and-deep-sequencing (accessed 29 February 2016).
11. Beutel J, Fitzpatrick J, Horii S et al. Medical Imaging. In: Beutel J, Kundel H, Van Meter R (eds). Handbook of Medical Imaging. Vol 1. Bellingham, Washington USA: SPIE Press; 2010:1–16.
12. Zimmern R. PHG Foundation. Whole Genome Sequencing: Savile Row or Marks &Spencer? 2014. www.phgfoundation.org/blog/16159/ (accessed 29 February 2016).
13. Clayton-Smith J, Newbury-Ecob R, Hurst J, Mcconnell V, Tatton-brown K, Mckay V. The Evolving Role of the Clinical Geneticist, 2015. www.bsgm.org.uk/media/956131/theevolvingroleoftheclinicalgeneticist_29.07.15.pdf (accessed 29 February 2016).
14. Nguyen MT, Charlebois K. The clinical utility of whole-exome sequencing in the context of rare diseases – the changing tides of medical practice. Clin Genet 2015;88:313–319. doi:10.1111/cge.12546.
15. Luheshi L, Raza S, PHG Foundation. Clinical whole genome analysis : delivering the right diagnosis. Phg Found. 2014;January:1-4. www.phgfoundation.org/briefing_notes/97/? (accessed 29 February 2016).
16. NHS England. Five Year Forward View, 2014. https://www.england.nhs.uk/ourwork/futurenhs/ (accessed 29 February 2016).
17. Bell J. Accelerated Report Title Access Review: Interim Report. Review of Innovative medicines and medical technologies, Supported by Wellcome Trust Oc.; 2015. https://www.gov.uk/government/uploads/system/uploads/attachment_data/file/471562/AAR_Interim_Report_acc.pdf (accessed 29 February 2016).
18. Monitor Deloitte. Genomics in the UK: An industry study for the Office of Life Sciences. 2015;(September):32.
19. Davison V. HEE Genomics Education Programme.
20. HEE. Genomics Education, 2016. https://www.genomicseducation.hee.nhs.uk (accessed 29 February 2016).
21. West MA. Creating a culture of high-quality care in health services. Glob Econ Manag Rev 2013;18:40–44. doi:10.1016/S2340-1540(13)70007-0.
22. Ganz M. Leading change. Leadership, organization, and social movements. In: Nohria N, Khurana R, eds. Handbook of Leadership Theory and Practice. Vol Boston MA: Harvard Business Press, 2010.
23. National School of Healthcare Science. Careers in Healthcare science, 2015. www.nshcs.org.uk/for-trainees/careers-healthcare-science (accessed 29 February 2016).
24. Hopkins MM, Martin P, Nightingale P, Kraft A, Mahdi S. The myth of the biotech revolution: An assessment of technological, clinical and organisational change. Res Policy 2007;36:566–589. doi:10.1016/j.respol.2007.02.013.
Publishing team
RCPath


South america vintage chunky weighty sterling silver figural charm is one images from stunning 46 images south charms of Baxters Homes photos gallery. This image has dimension 600x600 Pixel and File Size 51 KB, you can click the image above to see the large or full size photo. Previous photo in the gallery is patricia altschul whitney sudler smith premiere quot ultrasue. For next photo in the gallery is pin cameran eubanks southern charm pinterest. You are viewing image #42 of 46, you can see the complete gallery at the bottom below.


Lone Star State of Texas. We have several examples of Match.com successes in Texas. Join Match.com to meet real singles like you today! Flirting with the idea of dating again? View thousands of hot Waxahachie single men and single women looking for dates on Match.com.


text:
Begin searching
Pharmacovigilance Consultancy
REG+
FDA releases draft guidance for post-approval changes to drug substances
Posted at 14:24 on September 12th, 2018 in Generics, Industry news
The US Food and Drug Administration (FDA) have released new draft guidance for drug manufacturers who are looking to make a change to the drug substance manufacturing process during an application's post-approval period.
The draft guidance, which was completed as part of a commitment to the reauthorisation of the Generic Drug User Fee Amendments (GDUFA II), contains recommendations for holders of approved new drug applications, abbreviated new drug applications and holders of drug master files, who may want to make a change to the drug substance manufacturing process during the drug product application post-approval period.
The draft guidance details information regarding the following:
facility, scale and equipment changes that are associated with all steps of drug substance manufacturing
specification changes to starting materials, raw materials, intermediates and the unfinished and final drug substance
synthetic manufacturing process changes
changes in the source of drug substance
change to container closure system of the drug substance.
The draft guidance states that late-stage changes in the drug substance manufacturing process may be "more likely to have an adverse impact on the quality of the drug substance and, consequently, on the drug product".
The responsibility for reporting the types of changes described in the guidance may lie with a single party or with several parties, depending on whether the drug substance synthesis or processing is described in an application or in one or more master files. The draft guidance also states that "notification to FDA should include reference to the section of this guidance under which the change is made and all pertinent information to ensure the quality of the drug substance and drug product."
To read the draft FDA guidance on post-approval changes to drug substances, please click here.
FDA release draft guidance on the uncertainty of medical device benefit-risk determinations
Health Canada launches pilot project on new meeting framework for pre-clinical advice on devices
Detailed guidance on the electronic submission process for applications to the UK
The FDA details their plans to advance regulatory science in 2021
European Commission Decision Reliance Procedure provides a new route to obtain marketing authorisations in Great Britain
European Commission temporarily allows notified bodies to perform remote audits
EMA publishes second issue of their Clinical Trials Information System (CTIS) Highlights newsletter
ATMPs [13]
Awards [7]
Brexit [97]
CMC [12]
Company news [36]
Compliance [13]
COVID-19 [22]
EMA [47]
FDA [31]
Generics [14]
GMP [31]
International [35]
Medical device [126]
Medicinal product [96]
MHRA [24]
Paediatrics [6]
Post-licence maintenance [3]
Press [6]
Product information [23]
PV [86]
Regulation [271]
Trials [74]
Uncategorised [1]
Winner of TOPRA Support Award 2019
© 2021 Regulis Consulting Limited. All rights reserved. Registered in England 04164163
Created by Satellite.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: 'findmnt --verify' gives warning: 'cannot detect on-disk filesystem type' I used findmnt --verify to verify some changes I did to /etc/fstab. However to my surprise it gave me the warning
/
   [W] cannot detect on-disk filesystem type

for my root partition. A quick check with df -T / shows
Filesystem     Type 1K-blocks      Used Available Use% Mounted on
/dev/sdb2      ext4 116778960 107259980   3543840  97% /

Is the on-disk filesystem type something different from the filesystem type of the partition?
If not, is the warning legit or a missing feature/bug? (findmnt --version gives findmnt from util-linux 2.31.1)

A:
Is the on-disk filesystem type something different from the filesystem type of the partition?

No.

is the warning legit or a missing feature/bug?

Legit but somewhat misleading. It could be findmnt: /dev/sdb2: Permission denied.
Regular users cannot read /dev/sdb2 directly, so the tool cannot verify if the device holds a filesystem that matches the corresponding fstab entry. Run sudo findmnt --verify. The tool will be allowed to examine /dev/sdb2.

A: The next version (v2.38) will print the reason, for example
[W] cannot detect on-disk filesystem type (Permission denied)

redpajama_set_name: RedPajamaStackExchange


In a previous post, I wrote how website credibility, or creating credibility with your website, should be a small business' number one objective. In my post, titled Credibility is Paramount for Small Business Websites, I suggested that creating credibility for your organization should be a significant part of your website strategy, possibly even more so than site visibility (via search engine rankings) - although both strategies should be connected. The basic reason for this is that credibility can dramatically impact not only your online conversions, but offline conversions as well, which can lead to greater sales and enhanced brand perception.
So if credibility is so important, what can you do to positively impact your organization's credibility on your small business website? The truth is I have no idea. OK, I do have some idea, but as each business is different, so too will each plan be to create credibility for your organization. And, as I don't know your organization like you do, I also can't create a credibility plan that will completely fit your business – at least not until I learn more about your organization and your dealings. So, as you read through the rest of this article, use it as a starting point for your own organization's credibility plan or something to get your creative juices flowing. With that said, here are three (3) main components to creating credibility on your home page and throughout your entire website.
As I mentioned in my previous article, your website is the new yellow pages for your business – it's the first place any prospect will go when they want to learn more about your organization and what you do. With that said, you don't want them arriving to your homepage and immediately having a poor experience (and opinion of your company). That's what will happen if your site is old, outdated or poorly designed – even if you have good content within your site.
If your site looks unprofessional or unorganized, a prospect may never even take the step of browsing your site for specific content. If you have a high home page bounce rate, this could be the reason. Think back to the last time you went shopping in a new mall for the first time. You walk around and stick your head in a few stores to see if they quickly interest you. If they don't quickly grab your attention, you don't walk in and browse – instead you move on to the next storefront. Same thing with your website – make a positive impression in the first five to ten seconds, or the user will move on to other options.
Now days you also need to make that positive impression regardless of the device (desktop, tablet, phone, etc.) your audience is using. If you don't have a responsive web design or mobile friendly site, odds are that smart phone web viewers will not have a positive experience.
When I visit a website for the first time, my mental processing works like this. First, can I tell what the organization does in the first few seconds and do I get a generally favorable impression from the site's overall appearance? If so, I then move on to my specific need or reason for searching or visiting that site. Does the organization offer the product, service, or information I'm looking for? If the answer is "Yes" again and I quickly see that high level offering (product, service, etc.), then I move on to specifics that will make me more comfortable in taking some next step (conversion), whether that next step is buying, making a call, or downloading an article.
So depending on what your organization does, what type of content will portray you as an expert, provide credibility, and make me more comfortable so I will take that next step (conversion)? Certain content, such as awards, press releases, membership in associations, or featuring well known customers, will provide basic confidence that your organization is credible. Different types of content can really hook me and drive me further down your purchasing or conversion cycle. If, for instance, I'm searching for a service offering, my next thought process may be whether your company has specific experience with my type of company or industry. Testimonials, case studies, project galleries, or white papers – specific to my industry or more specific needs (project type for example) – give me a much greater level of comfort that you are a viable option. Specific blog posts that touch on details (examples, industries, specific types of projects, etc.) can also provide that same level of reassurance I'm looking for, while positioning your organization as a leader in your space.
The third way to create web credibility is directly related to the strong content I discussed above. A strong social media presence can reinforce the positive impression your website provides, while allowing you to leverage some of that compelling content across multiple channels that encourage sharing and that will drive more eyes to your site. Nowadays, you may have certain individuals that start their search via different social media channels such as Twitter, Facebook, Linked In, Google+, or even Pinterest or Instagram if you have robust visual content. Having a strong presence on these sites will drive visitors to your website, but will also provide yet another level of comfort for those prospects that use that particular social marketing site. Reviews via sites like Google+, Facebook, Yelp, or Citysearch can also enhance credibility and help drive conversions, especially in certain industries (restaurants, service business, etc.) where reviews are prevalent. With that said, most small organizations don't have the resources to have a positive presence on all the sites I mentioned. I'd recommend starting small and doing one or two social sites well, rather than trying to manage too much too soon. Remember, a poor impression on a social media site can be much worse than not having a site, and will hurt your credibility.


Maybe this year you will skip the beach holidays. Culture, nature and sports: perfect mix for your young ones!
Centuri is a little village and harbour which serves the best crayfish in France! Spend time visiting this authentic village, eat in one of the local restaurants and enjoy the peacefulness of this enchanting place.
A sweet escape, far from the over-crowded summer season. This trip is great if you want to discover the beaches and coastline of the South. With the flexibility and autonomy of having a car with you, there is plenty to do and see. You will wish to stay longer!
Some of my favourites on this Croatian adventure are the waterfalls of Krka.
Our best family holiday in Corsica! A beautiful and unspoilt region of Corsica with exceptional scenery. Children love having to take care of their donkey throughout the trip - the difficulty is saying goodbye! Experience Corsica at its most authentic and at its very best.
As an Italian, I just love sharing our local culture, cuisine and history with travellers from all around the world. Italy should be everyone's to enjoy!
Cinque Terre... five villages overlooking the sea, breathtaking views and astonishing walking itineraries for everyone. The ideal vacation for nature lovers!
A brilliant way to discover Corsica's past and culture! This trail offers magnificent landscapes. One of my favourites: the Needles (or peaks) of Bavella. When I walk the Mare a Mare South, I also love visiting Sainte Lucie de Tallano and tasting the village's famous olive oil.
This is such a good trail! Rather easy and full of charm with brilliant little French B&Bs, friendly locals and delicious food.


After work yesterday, I decided to wander around Union Station and Olvera Street. I saw another photographer photowalking, so I struck up a conversation. We ended up hanging out for 30 minutes[1. It was much longer than I planned to stay around, but I'm glad I did.].
Miles is a freelance photographer from Maryland, visiting some friends and relatives in San Diego. He does all sorts of assignments: glamour shots, portrait work and weddings. That covers photography expenses and living. But, his passion is documentary and photojournalist-type photography. He recently traveled to Iraq to document the war (protected with an Army platoon) and Istanbul.
In Los Angeles, he went to Venice Beach to photograph the surfers. The pedestrians on the boardwalk looked at him funny, but didn't start any confrontations (unlike my friend, Brian Auer). He also loved Hollywood Blvd. In a nut shell, he wandered the streets the night before from 11pm to 2am. Then, he went back to his hotel[2. I don't know if he stayed at a hotel, but I'll just say that to keep it simple.], slept, and woke back up at 6am to capture the emptiness of the streets.
Miles uses a Nikon D3, but had to resort to his Nikon D200 because he didn't charge any of his four batteries[3. Shame on him! :)]. He also had an hard drive backup device (independent — no computer required) and a few lenses.
We also talked about processing photos. He primarily uses Adobe Photoshop CS3 and Photomatix Pro, but also Lightroom. His photographer friend, Dennis, uses Lightroom heavily and constantly tries to persuade him to get into it. But, Miles can't break the habit. As for me, all I use is Lightroom (and Photomatix Pro for HDR).
Confidently act the part of a photographer. Want a good photo of a stranger? Just take it and don't try to hide. When they look at you funny, just smile back. At one point, he was even bold enough to stop a chic-looking lady, ask her to step into better light, and pose a bit.
If you're on public property, everything is fair game. Someone starts nagging you? Ignore them — that's what Miles does.
Do what you love. Miles does lots of gigs just to make enough to get by and buy better equipment. I could totally feel his passion for photography and it's inspiring.
Find your niche. He pointed out that I'm in the right place (Los Angeles) because so many people here want to become models or actors.
I had a problem writing this because Miles can't be found online — he wouldn't give me his last name, either[4. If it's any consolation, he promised to email me.]. This is all good and dandy, but slightly in vain if I can't promote his photos. He says he's building his portfolio, but from the experiences he shared, it sounds like he has a ton of photos ready to be seen.
I gave him my card, told him to get something online, then wished him a safe drive back to San Diego and wherever else he was going.
Miles, I hope I hear from you and that you start to display your photos online somehow — if you don't want to use Flickr, try SmugMug or Zooomr.


text:
David Lynch: The Early Short Films (1966 -1995)
A dancer's movements bring a chorus of women and unexpected choreographies to life.
10 – 15 | 2011 | Dance | Experimental | USA | Video Art
Sometimes, the most radical innovations are inspired by the past. This is the case of Michael Lagan and Terah Maher who took on the discourse on the deconstruction of the movement started by Marey's chronophotography and Muybridge's subsequent, and created one of the most innovative shorts recently seen. Choros is a hymn to dance, to the body gestures, a dreamy study on our perception of the movement, as well as an open tribute to Pas de Deux , Norman McLaren's pioneering short. McLaren in 1968 used multiple exposures on film, while Maher and Lagan relied on a mixture of compositing techniques to multiply endlessly the dancer's movements, the draw shapes and figures in the air. The music of avant-garde minimalist composer Steve Reich perfectly ties in with the images, and sounds and movements blend together, while the dancer (Terah Maher herself) is multiplied into space, creating an illusionary dance ensemble that performs complex choreographies . This chorus of women "travels" through three stages of thehuman existence, discovery, euphoria and rebirth , in a surreal journey suspended between reality and hallucination.
Flavia Ferrucci
Michael Langan, Terah Maher
Langan Films
Jimmy Page: An Animated Short Film Chronicles The Story Behind Led Zeppelin Guitar
The 1959 Fender Telecaster was a gift from Jeff Beck and now Page shares the psychedelic story of that instrument
Agua Viva – by Alexa Lim Haas
A short animation about feelings that no language can describe.
Memoria del fuego – by Francesco Clerici
From the director of "Hand Gestures," the manufacturing of Cuban cigars in a factory in Estelí, Nicaragua
Danger Island
A couple of british poachers set sail to explore a string of previously undiscovered islands in search of the...
A couple of british poachers explore undiscovered islands in search of the fabled Moth Owl, in this animated tribute to old b-movies.
Caveirão
São Paulo do Brasil, night time. It's 3:33 am and the time stops. We are in a deserted area...
Every night, time stops for a moment in Sao Paolo, and ghosts and mosters of all kinds dance and play music on the city's deserted streets.
(Hornet)
Brazil / 10minutes
Kung Fury
Kung Fury is a medium-length film (30 '), written and directed by the young Swede...
A cop martial arts expert is sent back in time to defeat Hitler...
(Laser Unicorns)
Sweden / 30minutes
Borrowed Time – by Andrew Coats & Lou Hamou-Lhadj
Animated short film and drama. We are not used to associate this genre to poignant and dark tales, but watching Borrowed...
American animation comes out of its comfort zone and tells the drama
(Quorum Films)
Jaffa – by Jay Branagan
Between thirty and forty years, for many people life takes a common turn: marriage, sons, a stable job and...
Many couples want a child, but what happens when a child does not arrive because of his sperm?
(Plain Sailing Films)
Ireland / 12minutes
Guida – by Rosana Urbes
Guida has dedicated her life working as an archivist, her days, for thirty years, are marked by an unabashed...
Beauty of life is ageless.
(Belisa Proença)
Similo
2065. The entire planet is facing the climate change aftermath. One of the few habitable places left is Antarctica,...
A sci-fi romance set in a dystopian future questions about artificial love and the future of humanity. (NSFW)
(Blackmeal)
Spain / 22minutes
Mostly known as Amy Pond in "Doctor Who" or the Nebula of "The Guardians of the Galaxy", Scottish actress Karen...
A horror film actress deals with her fall from stardom and learn the true nature of the genre.
(FunSize Horror)
Online Premiere: Arianna
Arianna is the title of the promo-short realised by Roman director Carlo Lavagna to promote the crowdfunding campaign on...
How to turn a simple crowfunding promo into a short masterpiece.
La Boca Del Léon
La Boca Del Léon is a story directed by Alfonso García López and written by Vincent Blonde, inspired by the...
A man obsessed with the world of dead messes up with the dark arts and make one last call for help.
(Geo Films)
Spain / 5minutes
Memories of Papé, the short film by Nicolas Polixene
Memories of Papé Diary of my short film. The beginning My name is Nicolas Polixene and I'm 33 years old. Native...
The private diary by French director of Martinique descent
The Tree – by Cheikh Mohammed Horma
A lumberjack travels in the desert. There're just sand dunes, ants, dromedary camels and bulldozers around him. A bunch...
An immersive visual experience of Sahara desert, exploring the changing balance between man and nature
(Sahara Lab)
Morocco / 9minutes
Goat Witch
Weird things happen in the woods of Georgia. For example, coming across the occult universe of James Sizemore and...
From the creators of 'The Demon's Rook' comes Emelin & Gloria's ancient ritual: witches, demons, and deities during a full lunar eclipse…
(Black Rider Productions)
Scrambled – by Bastiaan Schravendeel
Can a Rubik's Cube still be an intriguing game for millennials? It is probably the question that the animators...
The immortal charm of the Rubik's cube
(Polder Animation)
Netherlands / 7minutes
Transmission – by Varun Raman and Tom Hancock
After a long and extremely successful run in the festival circuit, British dystopian short film Transmission is now available...
Welcome To Britannia. Together We Stand Alone.
(Parallel Madness)
Little Shit – by Richard Gorodecky
The acclaimed short film Little Shit by Richard Gorodecky has collected many awards in its festival run, including that...
A child's journey to discover his and London's hidden nature
(Post Panic)
Out in 2013, then removed from the web, now online again, this time permanently, Noah is the debut short film,...
A "screenager romance" with a spymovie-turn between attention disorder e social networking.
Killing Klaus Kinski – by Spiros Stathoulopoulos
Killing Klaus Kinski by Spiros Stathoulopoulos, Greek-Colombian director best known for the uncut cult film PVC-1 (2007) and Meteora...
The vertiginous reimagination of a myth of the history of film: the filming of Fitzcarraldo by Werner Herzog
(Candelaria Films)
Colombia / Greece / 20minutes
Minako, a young Japanese female, lives in a Tokyo penthouse with her European boyfriend, a successful musician. One morning she...
A Japanese lady holds an intriguing double life, but her secret is about to be discovered.
(DAYFORNIGHT)
A new short film from Federico Heller explores a well travelled dystopian sci-fi narrative territory—addiction to future technologies, war and...
In the slums of the future, virtual reality junkies satisfy their violent impulses in online entertainment.
(3dar)
Argentina / 9minutes
Written by proven duo Drew Grubich and Nickolas Duarte, fresh authors of the award-winning Fish Hook, Sea Change is a...
Two sisters travel up to Pacific Coast to seek an alternative treatment for the younger sister's misterious disease.
(Crown Chimp Productions)
Blending together science fiction and melodrama, Joe Sill's Expo is a short that combines a great visual impact to...
Science fiction and melodrama come together in this story of loss, loneliness and survival.
(Everdream Pictures )
Ca' Foscari Short Film Festival Unveils Its 7th Edition
From 15 to 18 March 2017 the spotlight will be on the Auditorium Santa Margherita in Venice for the...
The first film festival in Europe to be entirely conceived, coordinated and managed by students reveals Jury and poster
The Driving Seat – by Phil Lowe
In order to properly write about this short movie, I felt the need to listen in loop Perfect by Ed...
The hilarious attempt of a middle aged couple to put a spark back in their marriage
(Turn the Slate Productions)


Welcome to your Bay Watch III Homeowner's page. Here you will find information that is contained in the Information Bulletins that are sent out to each resident. These documents provide a wealth of information regarding winterization and rental policies just to name a few.
Upon logging in, (please have cookies enabled) you will be able to access our by-laws, rules and regulations of our condominium and amendments to those rules, and a forum that you can use to post a message to fellow owners or a contact form to contact just the board members. Additionally you will be able to access owner's information if you require the need to contact only one specific owner and you will have an opportunity to update your contact information. We request that you keep this information current as it is imperative that we are able to reach you in case of an emergency.


Look through the listings of Member users here at BHM Personals that are tagged with French. Dating others who have similar interests is an ideal way to come up with ideas to do once you are dating. Register for a Free Account to Meet Someone Tonight!


Therese Halscheid was one of the six featured poets at the 2015 West Caldwell Poetry Festival.
Therése Halscheid's most recent book of poems is Frozen Latitudes (Press 53). Other collections include Uncommon Geography, Without Home, Powertalk, and a Greatest Hits chapbook. Her poetry and lyric essays have appeared in many journals, among them The Gettysburg Review, Tampa Review, Crab Orchard Review, and Natural Bridge. By way of house-sitting, she has been an itinerant writer for several years. Her travels have taken her from the Florida Panhandle to the Arctic north of Alaska, where she lived with and taught poetry to an Eskimo Inupiaq tribe.
Frozen Latitudes melds two journeys, where lives are at the very edge of survival. One is the literal location of Alaska where Halscheid lived among clans of an Inupiaq tribe, as well as in the frontier town of Homer. The second location is the place and time where her father's life was frozen when, during heart surgery, he suffered brain damage. In this collection, the journey into the cold becomes a metaphor for a family struggling with dementia.
"'My lips, bright as scars, are parting / open with words,' writes Therése Halscheid. In these moving poems of loss, interwoven with vivid poems inspired by people and the landscape of Alaska, she composes resonant lines imbued with deep emotion."
Frozen Latitudes won Honorable Mention for The Eric Hoffer Book Award for Poetry. The collection is reviewed in the US Review of Books. Read the Review.
This is how it really looked long ago….
that full of my father….
watching the weather above them.
And this is an image of the whole town in shock.
Select a topic that is risky for you and allow yourself to free-write about it. A few lines, a paragraph, a page, it does not matter. Just spend a few moments writing. Then go back to what you have written and circle a sentence or phrase. Lift it out. Using that sentence or phrase as a starting point, free-write again. This exercise is helpful in allowing you to experience how writing unfolds in layers. Note how you are moving from a surface experience to crisp details, from abstracts to images. You can try this again and again as a way to enter the heart of the matter, which then becomes powerful material for a poem.
R.G. Evans, aka Bob, was one of six featured readers at the 2015 West Caldwell Poetry Festival.
R.G. Evans' first collection, Overtipping the Ferryman, received the 2013 Aldrich Press Poetry Prize. His poems, fiction, and reviews have appeared in Rattle, The Literary Review, Paterson Literary Review, Lips, and Weird Tales, among other publications. His original music was featured in the 2012 documentary film All That Lies Between Us. He teaches high school and college English and Creative Writing in southern New Jersey.
Overtipping the Ferryman is a collection of poems ranging from the dark to the darkly comic. Themes include mortality, the art of poetry, grief and loss, and the natural world. Most of the poems are free verse, but the book includes formal poems such as sonnets and a villanelle as well.
and roam the darkened oblongs of the dunes.
and all the sky above is one dark dream.
between belief and what I know is true.
I gave you a diamond. It should have been a pearl.
It should have been a stone to hang above the world.
In one of the most famous scenes from the film Jaws, Quint, Brody and Hooper sit in the cabin of the Orca drinking and comparing various scars they have (moray eel bite, thresher shark's tail). Quint reveals that one mark on his arm is a tattoo he had removed: the USS Indianapolis. He proceeds to tell the true story of the Indianapolis, the ship that delivered the Hiroshima bomb and which ultimately sank, many of the survivors attacked by sharks before the rest could be rescued.
Like Quint's, the marks on our bodies tell the stories of our lives.
Make a list of all your bodily markings: scars, tattoos, piercings, etc. If you want to go deeper, you can list your emotional scars as well.
Write a poem either 1) in the voice of one of your scars speaking to you (recalling how it came to be, what it has to teach you, etc.) or 2) in the form of a dialogue between two of your scars/markings speaking about you in the third person.


The DuPage Airport Authority, after a closed-door meeting Monday, voted unanimously to drop a Union Pacific Railroad proposal to build a truck-train rail yard on 500 acres owned by the West Chicago airport.
Joseph Kindlon, chairman of the authority, said commissioners have the support of U.S. House Speaker Dennis Hastert (R-Ill.) and Gov. George Ryan to pursue the development of a high-technology business park.
Hastert has said he envisions a mix of business, science and education interests locating at the airport, similar to projects elsewhere such as in North Carolina's Research Development Triangle or the research park in Evanston near Northwestern University.
"It's over," Kindlon said, referring to months of negotiations with Union Pacific amid widespread community opposition. "We didn't have this option 60 days ago. When we weighed this decision, we decided this was the way to go."
Kindlon said there are no guarantees businesses will flock to airport land, which is south of Roosevelt Road. But he said he anticipates the involvement of the nearby Fermi National Accelerator Laboratory and further discussions with DuPage County government about extending Eola Road as a major north-south thoroughfare.
Thomas Zapler, spokesman for Union Pacific, said the Airport Authority's decision did not come as a surprise.
"We are disappointed in that decision, but surely we can understand it," he said. "My thought was they would continue to review the lease agreement to see if something could be worked out."
DuPage County Board Chairman Robert Schillerstrom (R-Naperville) helped pave the way toward the airport authority's decision by relieving the board of a previous charge to get the airport off the tax rolls.
Schillerstrom, who appoints the airport authority commissioners and has final approval over the airport budget, also opposed the Union Pacific plan.
"I feel very happy about it," Schillerstrom said of Monday's vote. "They shouldn't feel compelled to enter development just for the sake of development. We can look for better forms of development that suit the community, and suit the airport as well."
Union Pacific's railport proposal had drawn citizen and municipal protest in nearby communities, including West Chicago, Geneva, St. Charles, Warrenville, Winfield and Batavia. Residents in those communities feared increased truck and train traffic.
Union Pacific's plan called for a train-truck hub where up to 700 trucks a day would transfer products to and from trains.
"I'm hopeful that as a result of this we can start working with the airport authority, and that it will improve our working relationship," said a jubilant West Chicago Ald. Nancy Kifer Assian. "This opens the door for that to happen."
West Chicago filed a lawsuit against the DuPage Airport Authority late last year, citing the Union Pacific proposal as one example of a larger dispute regarding zoning issues and development. The disagreements stem from differing interpretations of an annexation agreement that brought the airport into West Chicago.
Union Pacific, which had not submitted a formal proposal for the railport, was negotiating a lease agreement with the airport that was "95 percent" complete, said Gordon Cole, the airport's executive director.
He said the most recent lease terms called for Union Pacific to pay $765 million in rent over 90 years.
The payments would have been phased in during the first five years, to up to $4 million, and continue to increase annually over the length of the agreement.
Some Airport Authority commissioners, after voting on the resolution to drop the plan, said there will be more issues to resolve.
"The only problem with developing something piecemeal is that someone has to pay for the roads, the sewers and the lights," said Commissioner Thomas McWilliams, estimating it could cost the airport $30 million for the infrastructure improvements.
As for the Union Pacific plan: "Everybody's against it," he said. "No matter what you say, you can't win."


text:
Youth Will Power SC 76ers At Deep South Classic
on January 8, 2014 by ASGR Basketball
The spring roster for the South Carolina 76ers will include a number of talented players from the Class of 2015, but the stars of the program in the coming months will be from the 2016 class. That fact should make the spring an exciting, interesting time for 76ers coach Roger Wiley.
"We are going to be extremely talented, but we are going to be very young," Wiley said. "We lost a number of players to graduation. About half our team will be from the 2015 class, but our starters will be from the 2016 class. They are tall and talented, but that's a lot of youth out on the court."
The 76ers will get an early challenge in Raleigh, NC, on April 25-27 at the Deep South Classic. Now in its 17th year, the Deep South Classic annually hosts many of the nation's elite travel teams in a field that will eclipse 200 squads, and hundreds of collegiate coaches will be on hand searching for talent. The 2014 event will mark the second year that the Deep South Classic has been held at the Raleigh Convention Center. The venue was a tremendous success in its debut last year, with all games played at one site on 18 courts, and it is in a convenient central location.
A trio of 2016 prospects will be in the spotlight for the 76ers. Jhileiya Dunlap is a 6-2 forward who is listed as the No. 42 recruit in the class by the All Star Girls Report. Christian Hithe is a 5-7 guard who is rated at No. 53 by ASGR, and Shaquanda Miller-McCray is a 6-3 post player.
ASGR analyst Bret McCormick has scouted all three players. "Dunlap is a long athlete who could play the three or the four because she has the skills to score from just about anywhere," McCormick said. "Hithe is a very strong combo guard with great skills, including a nice step back jumper and great shooting range. Miller-McCray is a long post player who blocks shots and scores inside. She has a lot of potential."
Wiley is confident that all three of his rising stars will shine this spring.
"Shaquanda is a player who brought up late last year, and people are just starting to notice her," the coach said. "She is a tremendous shot blocker and a great rebounder. Jhileiya is an amazing jumper who alters a lot of shots, and she is a great rebounder. Christian is our leading scorer, and I think she is our most talented player. She has amazing hang time and body control, and she is a great three-point shooter."


text:
Померанц Александр Джошуа (Померанц Ишия Авраамович) ( 1 мая 1901, Гродно — 9 января 1965, Нью-Йорк) — американский литературовед, публицист, журналист и переводчик.

Биография
Получил традиционное еврейское образование в хедере и иешивах. В 1921 эмигрировал в США. Окончил педагогический колледж. Издавал первые пролетарские журналы США «Spartak» и «Kuznie». Входил в состав редколлегии нью-йоркских журналов «Дер Хамер», «Сигнал» и «Югнт». Около 25 лет был сотрудником газеты «Морген фрайгайт». Помогал в написании биографий советских еврейских писателей для книги Ш.Нигера «Идише шрайбер ин Совет-Русланд» («Еврейские писатели в Советской России», 1958). Принимал участие в издании академического «Большого словаря языка идиш». В 1955-65 работал библиографом в библиотеке Еврейской теологической семинарии в Нью-Йорке.

Произведения
 «Пролет-пен» (1935, Киев)
 «А мейдл фун Минск» («Девушка из Минска», 1942)
 «Кавказ» (1943)
 «Церисене кейтн» («Разорванные оковы», 1943)
 «Рейзе ин дер цукунфт» (1944)
 «Ди советише гаруге-малхус» («Советские жертвы», 1962)

Примечания

Ссылки

Писатели на идише
Журналисты США
Писатели США

redpajama_set_name: RedPajamaWikipedia


A type of blood fat different from cholesterol may play a key role in heart disease, a study suggests.
Cambridge University researchers looked at the role of triglycerides, which is produced in the liver and derived from foods such as meat and dairy products.
The analysis of 350,000 people from 101 previous studies found those with higher levels of the blood fat were more likely to have heart disease.
But experts warned more research was needed to confirm the link.
The analysis centred on a specific gene which is known to influence the levels of triglycerides, the Lancet medical journal reported.
Previous research has looked into the issue, but has been inconclusive.
But the latest study found those with the variation in the gene which boosted triglyceride levels had an 18% greater risk of heart disease than those that did not.
Lead researcher Dr Nadeem Sarwar said the findings suggested the blood fat could be causing heart disease in some way.
But he added further research involving the lowering of the levels of the blood fat was now needed to confirm the suspicion.
"Such trials should help establish whether lowering triglyceride levels can reduce the risk of heart disease."
Mike Knapton, of the British Heart Foundation, said: "It could yet prove to be an important step towards tackling cardiovascular disease but we mustn't get ahead of ourselves.
"There still needs to be larger trials before we can know whether lowering triglyceride levels can reduce heart disease risks.
"For now, people should continue to follow advice on diet, exercise, stopping smoking and medication which are still the best ways to tackle your heart disease risk."
Dr Sonia Anand, of Canada's McMaster University, agreed.
"The true nature of triglycerides effect on coronary risk still needs further clarification."


text:
Эта статья — о населённом пункте. Об одноимённом озере см. Айнское (озеро).

Айнское — село в Томаринском городском округе Сахалинской области России, в 90 км от районного центра.

География
Находится на берегу реки Новая Айнская. Ближайший крупный город — Красногорск.

Часовой пояс

Айнское ранее находилось в часовом поясе, обозначаемом по международному стандарту как Vladivostok Time Zone (VLAT/VLAST). Смещение относительно Всемирного координированного времени UTC составляет +10:00. Смещение относительно Московского времени (MSK/MSD) составляет +7:00 и обозначался в России соответственно как MSK+7.

В настоящее время, с 2015 года, Айнское, как и весь остров Сахалин, находится в часовом поясе, обозначаемом по международному стандарту как Magadan Time Zone. Смещение относительно UTC составляет +11:00 Относительно Московского времени часовой пояс имеет постоянное смещение +8:00 часов и обозначается в России соответственно как MSK+8.

Список улиц
Основными улицами села Айнское являются:

История
До 1945 года входило в состав японского губернаторства Карафуто и называлось . После передачи Южного Сахалина СССР село 15 октября 1947 года получило современное название.

Население

По переписи 2002 года население — 111 человек (58 мужчин, 53 женщины). Преобладающая национальность — русские (83 %).

Примечания

Населённые пункты Томаринского городского округа


Can the folks at Airstory access My Stuff — the content that I'm writing, the notes I've highlighted, and so forth?
How does Airstory use the data included in My Stuff? I couldn't find this spelled out in the data storage & security guidelines.


text:
Q: Class App\Providers\Router does not exist in BoundMethod.php I have a provlem with my laravel. i have laravel peckage on repository gitlab
i try to clone it.
i found some problem and fix it. but i can not solve this one.
 C:\xampp\htdocs\xxxxxxxx\vendor\laravel\framework\src\Illuminate\Container\BoundMethod.php

                        : new ReflectionFunction($callback);
    }

    /**
     * Get the dependency for the given call parameter.
     *
     * @param  \Illuminate\Container\Container  $container
     * @param  \ReflectionParameter  $parameter
     * @param  array  $parameters
     * @param  array  $dependencies
     * @return mixed
     */
     protected static function addDependencyForCallParameter($container, $parameter,
                                                            array &$parameters, &$dependencies)
    {
        if (array_key_exists($parameter->name, $parameters)) {
            $dependencies[] = $parameters[$parameter->name];

            unset($parameters[$parameter->name]);
        } elseif ($parameter->getClass() && array_key_exists($parameter->getClass()->name, $parameters)) {
            $dependencies[] = $parameters[$parameter->getClass()->name];

            unset($parameters[$parameter->getClass()->name]);
        } elseif ($parameter->getClass()) {
            $dependencies[] = $container->make($parameter->getClass()->name);
        } elseif ($parameter->isDefaultValueAvailable()) {
            $dependencies[] = $parameter->getDefaultValue();
        }
    }

    /**
     * Determine if the given string is in Class@method syntax.

the error from my laravel
any one can help me?

A: i found my answere. it's something wrong with my composer.json. in old composer.json is laravel/framework 5.1.*.
i try to change with laravel/framework 5.2.* and i run composer update --no-scripts. it's solved. thanks for your responce all


text:
Beware of the vanishing bonus account
By Sylvia Morris for MailOnline
Updated: 05:24 EDT, 10 June 2009
Savers should check the rate they earn on the high-flying accounts they opened 12 months ago. Those in one popular regular savings account could see their interest plummet from 10% to 0.1% - and that's before tax.
Hey presto: an account over 5% last year could now fall to below 1%.
Savers with Alliance & Leicester, Barclays, First Direct, Halifax, Derbyshire Building Society - now part of Nationwide - and Tesco are all in danger of seeing a drop in rate.
A year ago, banks and building societies, desperate to attract funds from savers after the money markets seized up, launched deals paying well above the 5.5% base rate at the time. The best paid more than 6.5% before tax on easy access accounts, and as much as 10% on fixed-rate regular savings.
Some were boosted by large bonuses to ensure top headline rates. But these bonuses, which often last for a year, are starting to vanish. If so, you could find you're earning well below the top rates.
The average rate paid on easy access accounts is just 0.16% before tax, Bank of England figures show. For cash Isas its 0.42%. But there are far better deals around. Under the Banking Code, banks and building societies do not have to tell you when the bonus runs out - a practice the Financial Services Authority says it is looking to change when it starts to regulate the savings industry on November 1.
The 1% bonus paid on Alliance & Leicester Direct Isa Issue 4 disappeared at the end of last month. Its savers now earn just 0.55%.
Derbyshire launched its Web Saver account on July 1 last year paying 6.55% before tax, including a 1% bonus for the first 12 months. Its current rate, excluding the bonus, is 0.84% after tax (1.05% before tax) - well below the internet account rates now on offer.
Yorkshire Building Society pays double this before tax - and, with the Derbyshire account, you are restricted to making four withdrawals a year. Tesco Internet Saver paid 6.25% before tax from May last year including a 12-month 1.5% bonus. Once you no longer qualify for the bonus, you earn 1% after tax (1.25% before).
Barclays e-savings Reward was a year old on June 2. It came with a 0.75% bonus for the first year.
Savers lured by its original 5.25% pre-tax will earn 0.4% after tax (0.5% before) in any month they make no withdrawals and 0.08% (0.1%) if they make a withdrawal once the bonus goes.
Savers who signed up for top fixed-rate deals will also see a big drop unless they act now. Halifax Regular Saver, on sale between June 9 and July 20 last year, paid a fixed 8% (10%) on your monthly savings. After this year, the bank moves your money into another account where you could earn just 0.08% (0.1%).
First Direct Regular Saver Isa, on sale this time last year, paid 7% fixed, tax free, for twelve months. After this, the account is renamed Cash E-isa with a rate of just 0.2%.
If you have a fixed-rate bond coming up to maturity you need to act - or your money could end up in an account paying 0.08% (0.1%).
Beware of vanishing savings bonuses


text:
Boston BOS
928 Massachusetts Ave
The Best Italian Restaurants In Boston
Our guide to the best Italian restaurants in a city that has a lot of Italian restaurants.
Where To Have A Group Dinner
Everyone finally agreed on a date for the group dinner. Choosing a spot should be the easy part.
The Best Restaurants In Cambridge
The 21 best restaurants in a city with a lot of great restaurants.
Tina Picz
Pammy's
Pasta / Italian in Cambridge / Riverside
Dan Secatore
Perfect For: Date Night Dinner with the Parents Drinking Good Cocktails Impressing Out of Towners
Sometimes we like something without being able to say exactly what it is. That pretty much explains love, irony, and the smell of a fresh can of tennis balls, which could be either the byproduct of the industrial rubber cleaning process, or the perfume of the tennis fairies who wove the balls together using the neon hair of a unicorn.
That's how we feel about Pammy's, a hard-to-classify restaurant between Central and Harvard Squares. It's Italian, but the key ingredient in our favorite dish is a Korean red chili sauce. It's a perfect winter restaurant thanks to a wood-burning fireplace, but it also works in the summer with giant windows and a dining room that looks like a Restoration Hardware exploded inside a Mediterranean villa. And it's a good spot to take a date, but, without a single flickering candle in the whole place, it isn't really a traditional date night spot. So what is Pammy's? It's a place that just works. Pick almost any adjective you want, stick an -ish on the end and that will begin to describe it.
Generally, you should be wary of something that's "ish." If your doctor tells you surgery was "successful-ish," get a new doctor. If your friend tells you they're "close-ish" to the theater, be prepared to whisper-recap the first third of the movie. But Pammy's is the exception to ish-wariness. Here, the ish is the good stuff. It's what makes the food way more interesting than what you see in a Barilla Pasta commercial, and it's what makes it a restaurant that's appropriate for almost any situation and almost any kind of person. When you don't know exactly what you want or expect out of a night, head to Pammy's and let the ish provide.
Look around you on any given night here and close to half of the dining room will be eating the bolognese with the Korean gochujang sauce. They're not wrong to do so - it's a really good and interesting take on a dish that you've been eating since the days when you thought that Olive Garden breadsticks were the food of the gods. But the whole menu is filled with things that you'll only kind of recognize but come to love. Take the bucatini, a dish you may initially try to send back thinking the server mistakenly brought you a salad, only to find that an entire farmer's market's worth of fresh greens really does work with pasta, pistachios, and shrimp that's sweet enough to be sold out of an ice cream truck. Pammy's has taken what might be the most ubiquitous cuisine in America and given it little tweaks that you rarely see anywhere else. It's not so much that they're reinventing the wheel, it's just that they're saying "Hey, wouldn't wheels be a little bit better if they came with in-season strawberries instead of axle grease?"
The word is already out on this place, so expect it to be packed just about every night. But again, that's just a testament to the restaurant's flexibility. There will be dates, there will be neighborhood regulars, and there will be Harvard undergrads proud of themselves for making it so far out of the square. That's what you get with a restaurant that's just plain good all-around. It may be hard to say exactly what Pammy's is, but it's not hard to like it.
Food Rundown
Marinated Artichokes
They're made with a Middle Eastern garlic sauce, and they're way better than those marinated artichokes you get in tiny glass jars in the grocery store (though let's be real: standing at the fridge and eating those right out of the jar is great).
Bluefin Tartare
It's a little hockey puck of tuna, asparagus, and potato chips. The chips initially seem a little out of place with those fancy ingredients, but they pull their weight.
It's got a ton of anchovy flavor, so if that's not your thing, stay away. But if you like them, dive into this salty, cheesy pasta dish and swim around a while.
Bucatini
The shrimp in this dish are sweet enough you'll think they're candy, but they're also served with a salad's worth of uncooked greens, so you don't need to feel guilty about eating candy for dinner.
It's a Korean-Italian hybrid bolognese, and it makes us want to see the Italians and Koreans team up more often (thing of how stylish and practical a Kia-Ferrari would be).
Pork Milanese
It's very rich, very galicky, and very good. There's no shame in not finishing, just please try to do better next time.
Date Night Dinner with the Parents Drinking Good Cocktails
More spots in Cambridge
Santouka Ramen
Santouka is a great ramen spot in Harvard Square that kind of feels like a spaceship.
Loyal Nine
Loyal Nine is a restaurant focused on regional foods with a nice patio in East Cambridge.
Oleana is a very good Mediterranean restaurant from the same people behind Sarma and Sofra.
Muqueca
Muqueca is an excellent casual Brazilian restaurant in Inman Square.
More Italian spots
Galleria Umberto
Galleria Umberto is a pizza joint in the North End serving thick crust pizza for lunch.
Coppa is an excellent Italian restaurant in the South End.
The Daily Catch
The Daily Catch is an Italian seafood restaurant in North End with great squid dishes and wine in plastic cups.
Taranta
Taranta is an Italian-Peruvian restaurant in the North End that more people should know about.
SRV in the South End is a great Italian restaurant with plenty of room, outdoor space, and pasta.
Cafe Sushi
Cafe Sushi is an excellent sushi place in Harvard Square.
Little Donkey
Little Donkey is a small plates restaurant in Central Square that's great for drinks and few bites.
The Plough And The Stars
Go to The Plough & The Stars to drink double-strength cocktails and maybe dance to Justin Timberlake remixes.


text:
Saint Athanasius
May 31, 2022 Biographiesallyoucanbooks cancel, biographies, download free audio books, free audiobook downloads, free e books, free ebooks, unlimited biography books, unlimited ebooksaudiobooks-ebooks
Saint Athanasius by F. A. Forbes
A short and rather old fashioned biography a great saint. Don't expect subtlety; it's unapologetic hagiography. The saint is presented as a figure of pristine brilliance, courage and integrity and his persecutors as conniving villains. But to those who appreciate what was at stake in the controversy, Athanasius is indeed a God-sent hero. This is an informative, if quaint, introduction to a fascinating figure in history.
May 30, 2022 Biographiesallyoucanbooks.com, audio books free, biographies, ebooks free, free audiobook, free kindle books, unlimited audio books, unlimited biography booksaudiobooks-ebooks
Martin Luther by Carl E. Koppenhaver
This short, engaging volume summarizes the life of a priest who, intending to spark a lively academic debate by nailing 95 theses on a church door, unwittingly sets the continent aflame with the 1517 Reformation of the Catholic Church.
May 19, 2022 Biographiesallyoucanbooks.com review, biographies, free audio books online, free audiobooks, free books online, free ebooks download, unlimited audiobook subscription, unlimited biography booksaudiobooks-ebooks
The French Revolution by Thomas Carlyle
The French Revolution: A History was written by the Scottish essayist, philosopher, and historian Thomas Carlyle. The three-volume work, charts the course of the French Revolution from 1789 to the height of the Reign of Terror (1793–94) and culminates in 1795. A massive undertaking which draws together a wide variety of sources, Carlyle's history—despite the unusual style in which it is written—is considered to be an authoritative account of the early course of the Revolution. Volume 1 is titled 'The Bastille'
The Lives of the Painters, Sculptors & Architects, Vol. 1
May 9, 2022 Biographiesall you can books, audio books, biographies, books, download audio books, free audiobooks download, free ebooks for kindle, listen to books online free, unlimited biography booksaudiobooks-ebooks
The Lives of the Painters, Sculptors & Architects, Vol. 1 by Giorgio Vasari
The Lives of the Most Excellent Italian Painters, Sculptors, and Architects, from Cimabue to Our Times, or Le Vite delle più eccellenti pittori, scultori, ed architettori, as it was originally known in Italian, is a series of artist biographies written by 16th century Italian painter and architect Giorgio Vasari, which is considered "perhaps the most famous, and even today the most- read work of the older literature of art", "some of the Italian Renaissance's most influential writing on art", and "one of the founding texts in art history". Vasari's work has been described as "by far the most influential single text for the history of Renaissance art" and "the most important work of Renaissance biography of artists". Its influence is situated mainly in three domains: as an example for contemporary and later biographers and art historians, as a defining factor in the view on the Renaissance and the role of Florence and Rome in it, and as a major source of information on the lives and works of early Italian artists. (Summary by Wikipedia)
Buffalo Bill from Prairie to Palace
Buffalo Bill from Prairie to Palace by John M. Burke
William Frederick "Buffalo Bill" Cody is one of the legends of the American western frontier. As a teen he rode for the pony expressed and then drove for the Union Army during the U.S. Civil War. He later rejoined the army as a scout and was awarded the medal of honor for his valor during the Indian Wars. His fame became worldwide, however, through his flamboyant Wild West shows which toured not only across the American West but through England and Europe. John M. Burke served as Cody's publicist and promoter for the Wild West shows, propelling him into celebrity status.


If John Choi was the protagonist of this story there would have been alcohol and women involved before it's conclusion.
Unfortunately, this is not entirely factually correct. While Dale's comments are true for the most part, I believe there needs to be more glowsticks, black slacks, and Sandstorm mp3s in this story to make it true.
Seriously, the guy wakes up to Sandstorm every morning.


Partnering with brands to find value in data.
Data is a commodity from which real value can be extracted. We endeavour to build the most complete dataset possible, by blending data from different online data sources. We have built our own search and extraction techniques, and also make use of industry-leading monitoring tools.
Our data analysis processes includes automated data cleaning and manual data enrichment. Our dedicated team of analysts is at the core of what we do. They ensure accurate results and a deep and holistic understanding of the data when compiling reports.
Getclosure has a strong business analysis ethic, we focus on finding meaning and value in the data we collect. We develop bespoke reports and services which fit with our clients' needs.
Our clients are partners. We work with them to understand their business and their industries.


SeaWorld Parks & Entertainment, Inc: Inviting applications for 'grant' to work with purpose and passion on behalf of wildlife and habitats worldwide, encouraging sustainable solutions through support of species research, animal rescue and rehabilitation and conservation education.
U.S. Fish and Wildlife Service: Inviting applications for 'Marine Turtle Conservation Fund' to provide financial support for projects that conserve nesting populations and habitat and address other threats to the survival of marine turtles in foreign countries.
U.S. Fish and Wildlife Service: Inviting applications for 'grant' to work with others to conserve, protect and enhance fish, wildlife and plants and their habitats for the continuing benefit of the American people.
American Society of Primatologists (ASP): Inviting applications for 'Conservation Small grant´to recognize and financial support for students and early career investigators from habitat countries who demonstrate potential for making significant and continuing contributions to primate conservation and 'Conservationist award' for conservation research or related projects, including conservation education.
The Keidanren Nature Conservation Fund (KNCF): Inviting applications for '2019 KNCF Grant Program' to projects for preserving biodiversity.
The Jana Robeyst Trust Fund (JRTF): Inviting applications for 'grant' to early career scientists/conservationists and non-profit organizations to carry out vital field conservation and research work in Africa.
Emerging Wildlife Conservation Leaders (EWCL): Inviting applications for 'grant' to help jump-start early career conservation professionals through a combination of skills training, networking opportunities and the completion of a wildlife conservation initiative that provides real benefits to imperiled species.
The Explorers Club: Inviting applications for 'Student Grants' to recognize the importance of new ideas and avenues of exploration.
Thomson Reuters Foundation: Inviting applications for 'the Reporting Illegal Wildlife Trading programme' to build the capacity of journalists to report on the issue of illegal online wildlife trade – improving both knowledge and skills and also help journalists to present new viewpoints, promote discussion and dialogue on the most strategic areas for intervention.
Columbus Zoo and Aquarium: Inviting applications for 'Columbus Zoo Fund for Conservation' to help hundreds of dedicated wildlife heroes across the globe protect threatened and endangered animals and their critical habitats.
The Walt Disney Company: Inviting applications for 'the Disney Conservation Fund' to give priority consideration to holistic programs addressing a significant conservation need.
The Morris Animal Foundation: Inviting applications for 'grant' for established Investigator, first award, fellowship training and pilot study grants on topics relevant to wildlife/exotics health and welfare.
Auckland Zoo: Inviting applications for 'The Auckland Zoo Conservation Fund Small Grants' to help provide relatively small levels of funding for ongoing projects or pilot programmes with clear conservation value.
Interdisciplinary Centre for Conservation Science (ICCS): Inviting applications for 'The Biodiversity Fellows Programme' to improve engagement between researchers, conservation practitioners in the international and local NGO sectors, and businesses developing and implementing corporate biodiversity strategies, in order that scientific research is informed by, and meaningful for, real-world conservation issues.
UK Department for Environment, Food, and Rural Affairs and DFID, Darwin Initiative: Inviting applications for 'grant' to support developing countries to conserve biodiversity and reduce poverty.
Prince Bernhard Nature Fund (PBNF): Inviting applications for 'grant' to help the conservation of endangered species.
Wildlife Acoustics, Inc.: Inviting applications for 'Wildlife Acoustics Scientific Product Grant' to support efforts in conservation and environmental stewardship.
Oklahoma City Zoo & Botanical Garden: Inviting applications for 'Small Grant Program' to support the conservation of imperiled species, habitats and their surrounding communities through species preservation, research and education.
European Outdoor Conservation Association (EOCA): Inviting applications for 'grant' to implement a conservation project.
The Takagi Fund for Citizen Science: Inviting applications for 'grant' to foster and support independent Citizen Scientists who propose well-founded criticism and scientific counterarguments about problems and threats caused by present-day science and technology.
Association of Reptile and Amphibian Veterinarians (ARAV): Inviting applications for 'ARAV Research & Conservation Grant' to fund clinically-oriented and/or conservation research projects involving reptiles and/or amphibians.
The Weeden Foundation: Inviting applications for 'grant' to Protect Biodiversity.
Cleveland Metroparks: Inviting applications for 'Grants' to support field conservation projects in Africa and Asia to help secure a future for wildlife and positively impact human communities.
The Nagao Natural Environment Foundation (NEF): Inviting applications for 'NEF Commemorative Grant Fund for Capacity Building of Young Scientists (CGF)' to help young scientists in this region grow up as world-class scientists in the areas of, or related to, conservation of wildlife and ecosystem in their own country or in the Asia-Pacific region.
WildlifePhoto.com: Inviting applications for 'wildlife photography contest series for 2018'.
International Iguana Foundation: Inviting applications for 'grant' to a wide range of species and programs.
Society for Conservation Biology: Inviting applications for 'Conservation Small Grants Program (CSGP)' to fund worthy conservation projects around the globe.
The Nature Conservancy: Inviting applications for 'NatureNet Science Fellows Program' to create a reservoir of new interdisciplinary science talent that will carry out the new work of conservation.
Cultural Survival: Inviting applications for 'Keepers of the Earth Fund (KOEF)' to support Indigenous values-based community development.
Whitley Fund for Nature (WFN): Inviting applications for 'Whitley Awards' for dynamic mid-career conservationists who are leading wildlife conservation projects in developing countries.
Nagao Natural Environment Foundation (NEF): Inviting applications for 'grant' to support academic and scientific research that will deepen knowledge of the nature conservation in developing countries in the Asia-Pacific region.
UNESCO: Inviting applications for 'Michel Batisse Award for Biosphere Reserve Management'.
Future For Nature Foundation: Inviting applications for 'The 2019 Future for Nature Award' to protect species of wild animals and plants by combining passion with action to create concrete results in nature conservation.
Chicago Zoological Society (CZS): Inviting applications for 'CZS CBOT Endangered Species Fund' to support conservation-oriented research.
The International Elephant Foundation (IEF): Inviting applications for '2019 Elephant Conservation and Research Funding Support'.
The Institute for Global Environmental Strategies (IGES): Inviting applications for 'SDM 2018 Call for Proposals' to contribute to the retention and enhancement of biodiversity in socio-ecological production landscapes and seascapes (SEPLS) for achieving the Aichi Biodiversity Targets.
The United Nations Development Programme (UNDP), the International Union for Conservation of Nature (IUCN) and its World Commission on Protected Areas (WCPA): Inviting applications for 'Pathfinder Award' to recognize outstanding and innovative solutions for protected and conserved areas, developed and implemented by individuals, organizations or groups.
The European Outdoor Conservation Association (EOCA): Inviting applications for 'grant' to implement a conservation project in any country around the world except North America (US and Canada – where the Conservation Alliance provides funding for conservation efforts from the North American outdoor industry).
The Pro Natura Foundation: Inviting applications for 'Pro Natura Fund' to conserve nature by supporting scientific researches and activities in areas other than Japan, especially in developing countries.
The BBVA Foundation: Inviting applications for 'The BBVA Foundation Frontiers of Knowledge Awards' to recognize fundamental contributions in a broad array of areas of scientific knowledge, technology, humanities and artistic creation.
The Barcelona Zoo Foundation: Inviting applications for 'grant' to promote projects in accordance with general objectives in the scope of research and conservation.
The National Geographic Society: Inviting applications for 'Big Cats Initiative' to advance conservation efforts benefitting big cat populations, protecting and restoring them and their habitats via field-based, action-oriented, direct, and quantifiable strategic programs.
The Nagao Natural Environment Foundation (NEF): Inviting applications for 'NEF Commemorative Grant Fund for Capacity Building of Young Scientists – CGF Programme' to help young scientists in this region grow up as worldclass scientists in the areas of, or related to, conservation of wildlife and ecosystem in their own country or in the Asia-Pacific region.
The Roger Williams Park Zoo: Inviting applications for 'The Sophie Danforth Conservation Biology Fund (SDCBF)' to support conservation programs that protect threatened wildlife and habitats worldwide.
Science for People and Nature Partnership (SNAPP): Inviting applications for 'grant' to deliver rapid solutions to the most critical challenges facing humans and our planet.
The Inter-American Institute for Global Change Research (IAI): Inviting applications for 'Co-funded Small Grants Program' for the role of ecosystem services in adaptation to global change for human wellbeing.
The University of St Andrews and ConocoPhillips: Inviting applications for 'The St Andrews Prize' to find innovative solutions to environmental challenges across the world.
The AEON Environmental Foundation: Inviting applications for 'The MIDORI Prize for Biodiversity' to raise public awareness about the importance of biodiversity and to contribute to the objective of the United Nations Decade on Biodiversity 2011-2020.
Agreement on the Conservation of African-Eurasian Migratory Waterbirds (AEWA): Inviting applications for 'AEWA Conservation Award 2018' to recognize and honour individuals, as well as government and non-government organizations and enterprises.
Mohamed bin Zayed Species Conservation Fund: Inviting applications for 'grant' to provide targeted grants to individual species conservation initiatives, recognize leaders in the field and elevate the importance of species in the broader conservation debate.
The Society for Marine Mammalogy: Inviting applications for 'Small Grants In Aid of Research' to help support marine mammal research in low-income countries.
Oasis Magazine and AITN Group: Inviting applications for 'Oasis Photo Contest'.
Food and Agriculture Organization (FAO): Inviting applications for 'Benefit-sharing Fund' to enable farmers around the world use and conserve adapted varieties, leading to increased productivity, on-farm incomes and nutrient-rich food, as well as enhanced resilience to production shocks and reduced adverse impacts to the environment.
The International Union for Conservation of Nature Netherlands (IUCN NL): Inviting applications to provide funds for local NGOs to acquire threatened patches of wilderness to create or expand safe reserves and connect wildlife habitats.
The International Zoo Educators Association (IZEA): Inviting applications for 'grant' to support Zoo and Aquarium Educators to attend the two yearly.
Ernest Kleinwort Charitable Trust (EKCT): Inviting applications for the funding theme- a) Wildlife & Environmental Conservation (UK and International); b) Reproductive Health (International).
Fauna & Flora International and Botanic Gardens Conservation International (BGCI): Inviting applications for 'The Global Trees Campaign (Student Grants)' to help meet the costs of Masters level research addressing questions relevant to the in situ conservation of threatened tree species.
BigPicture: Inviting applications to encourage photographers from around the world to contribute their work to this competition that will both celebrate and illustrate the rich diversity of life on Earth and inspire action to protect and conserve it through the power of imagery.
Auckland Zoo: Inviting applications for 'Conservation Fund' to help provide relatively small levels of funding for ongoing projects or pilot programmes with clear conservation value.
National Geographic Society: Inviting applications for 'grants' for conservation, education, research, storytelling, and technology through its Committee for Research and Exploration.


text:
Самуїл, у миру Неділка Самійло (? — † по 1769) — ієромонах, іконописець і маляр-портретист другої половини 18 ст.

Був учнем Алімпія Галика в іконописній майстерні Києво-Печерської Лаври. Близько 1754 року працював у Хрестовоздвиженському монастирі в Полтаві. З 1762 призначений «малярським начальником» Софійського монастиря в Києві. Відомі портрети Нектарії (у світі Наталії Долгорукої, тепер у Чернігівському історичному музеї) і Дмитра (1769; в Київському музеї українського мистецтва). Можливо, брав участь у розписах Собору Святої Софії в Києві.

Література

Українські художники
Українські іконописці