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California National Primate Research Center Successfully Demonstrates Gene Editing in Nonhuman Primates
Home/News, Press Releases, Reproductive Sciences And Regenerative Medicine, Research Units/California National Primate Research Center Successfully Demonstrates Gene Editing in Nonhuman Primates
Introduction to Genome Editing Using CRISPR/Cas9 from Innovative Genomics Institute on Vimeo.
Media Contact: CNPRC Info (530) 754 4413
(U.C. DAVIS) – Imagine a world where maladies such as cystic fibrosis, Huntington's Disease, or sickle cell anemia no longer exist. While the U.S. is far from achieving this lofty goal, it recently came a step closer at the California National Primate Research Center (CNPRC), where scientists have efficiently used CRISPR/Cas9 technology to modify the genes of rhesus macaque embryos.
The research, recently published in the latest edition of Human Molecular Genetics, paves the way for future studies where the possibility of birthing gene-edited monkeys that can serve as models for new therapies is greatly increased.
CRISPR, an acronym for Clustered Regularly-Interspaced Short Palindromic Repeats, is essentially a DNA segment that scientists can manipulate using a system known as CRISPR/Cas9 to edit the genes within organisms. CRISPR/Cas9 seeks and targets specific genes in organisms that are linked to diseases. It does this by utilizing a single strand of ribonucleic acid (RNA), a nucleic acid present in all living cells, as a guide to target specific genes for editing.
The editing of genes in animals using CRISPR/Cas9, and specifically in nonhuman primates is not new. For several years, scientists in the U.S. have edited the genes of fruit flies and rodents. In China and Japan, scientists have used Cas9 to edit the genes of nonhuman primates with little efficiency. This is because the technology can be imprecise – causing off-target effects to genes that were not intended to be targeted.
"One of the problems with the CRISPR/Cas9 approach is that you have to target the gene," said Dr. Catherine VandeVoort, the core scientist at the CNPRC who collaborated with Keith Latham of Michigan State University and Dr. Daniel Bauer at Harvard Medical School for the study. Latham designed the CRISPR/CAS9 system used in the CNPRC project. "When you have a very short (gene) sequence that you are targeting, it may show up in different places, in another part of the DNA strand instead of where you intend. It can cause off-target effects."
Another challenge with the process is that the longer Cas9 stays in the cell, the higher the likelihood of off-target effects, she said. While rodent-based models are good for studying diseases, rodents differ from humans in many anatomical and physiological ways making it difficult for rodent-based models to make the jump to human clinical trials. Alternatively, nonhuman primates share many similarities to humans, making them ideal models for studying human diseases.
While the monkey model is better for studying human diseases, it is also much costlier than rodent-based models. For example, the cost of raising a nonhuman primate can be roughly $15,000 and can take a long as 4-6 years to have a mature monkey with the desired genetic characteristics. Rodents with pre-disposed genetic characteristics can be easily ordered and shipped to laboratories within days and for a much lower rate.
"In monkeys, we can't afford any off-target effects and so we asked ourselves, 'How can we make this more efficient?'" VandeVoort said.
To minimize the risk of the off-target effects, the study used a two-pronged approach to increase the efficiency of the CRISPR/Cas9 targeting. In one group of embryos, the scientists used two RNAs instead of one to target binding sites on the HBB gene. The HBB gene is associated with sickle cell anemia and thalassemia, inherited blood disorders in which the body makes abnormal hemoglobin. In a second group of embryos, the scientists aimed to reduce the length of time that the Cas9 remained active in the cells by using protein rather than the RNA to edit the genes.
The scientists successfully edited the genes of the monkey embryos with 85 percent efficiency. Furthermore, the study demonstrated the first time in the U.S. that this method could effectively be used in monkey embryos. VandeVoort said the embryos used in the study were not implanted in recipient female monkeys, but that a future study will transplant the embryos with a goal of creating a gene-edited monkey.
For more information on this, and other studies occurring at the CNPRC visit cnprc.ucdavis.edu
web.cnprc@ucdavis.edu2017-05-02T17:26:28+00:00May 2nd, 2017|Tags: CRISPR, CRISPR-CAS9, cystic fibrosis, gene editing, Huntington's Disease, sickle cell anemia, thalassemia|
The CNPRC is an Organized Research Unit of the University of California, Davis and part of the National Primate Research Centers Program. The CNPRC mission is to improve human health and quality of life through support of exceptional nonhuman primate research programs.
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Programs of the California National Primate Research Center are supported in part by the Office of Research Infrastructure Programs (ORIP) of the National Institutes of Health through Award Number P51OD011107.
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Below is the text of the maiden speech made by Philip Hammond in the House of Commons on 17 June 1997.
I am delighted to make my maiden speech in the debate on this short but important Bill, which will have a significant effect on many of my constituents.
A number of my hon. Friends who are new Members have already made their maiden speeches. My tardiness owes something to Disraeli's advice to a new Member: "It is better they wonder why you do not speak than that they wonder why you do." It must be said that if I were looking for support from my colleagues, my timing has not been perfect; but Conservative Members are not so numerous that we can afford to carry passengers indefinitely and, for better or worse, the time has now come.
I have the privilege to represent the new constituency of Runnymede and Weybridge, which was formed largely from the former Chertsey and Walton constituency, with a piece of North-West Surrey attached to it. The boundary commission seldom wins friends when naming new constituencies, but that much-maligned body has surely got it right this time in including the historic name of Runnymede in the title of a constituency for the first time.
I am sure that many hon. Members envy me a constituency which stretches from the Wentworth golf course in the west to the St. George's hill course in the east, by way of another five first-class courses. It is, perhaps, in the interest of diligent pursuit of parliamentary duties that such a constituency should return a non-golfing Member.
I follow in the footsteps of a number of eminent Members who have represented areas that are now part of my constituency, but it is my immediate predecessors in Chertsey and Walton and North-West Surrey to whom I now pay tribute. Both Sir Geoffrey Pattie and Sir Michael Grylls did excellent work on behalf of their constituents over the years, in their different ways. My special thanks are due to Sir Geoffrey Pattie for the superb apprenticeship that he bestowed on me during the 18 months before my election. He served Chertsey and Walton for 23 years, becoming a Minister and a vice-chairman of the Conservative party. I can honestly say that, if at the end of my parliamentary career I have made half as many friends and admirers in my constituency as Sir Geoffrey has, I shall regard that career as having been a great success.
Runnymede and Weybridge comprises two local authority areas, the borough of Runnymede itself and part of the borough of Elmbridge. The constituency straddles the M25 and the M3; indeed, in those road atlases that tend to exaggerate the width of roads my constituency appears to contain little other than the intersection of those two motorways. It also comprises the ancient town of Chertsey, where the Romans first crossed the River Thames, Egham, Addlestone and Weybridge, as well as the historic site of Runnymede and that of the Tudor royal palace of Oatlands. Those historic locations, together with a selection of smaller towns and villages and the garden estates of Wentworth and St. George's Hill, are set in the beautiful Surrey countryside, which many people are surprised to find so close to London.
Most, if not all, hon. Members will recognise the name of my constituency and may even be able to locate it geographically through their knowledge of the events in 1215. The basis of constitutional government in England began to emerge when Magna Carta was signed in the meadows by the Thames, between Staines and Windsor, near the town of Egham. We can trace the origins of our modern freedoms to that event which took place in my constituency. It was on 15 June that year when the King and the barons first met at Runnymede. During the next few days, they negotiated the charter. I am delighted to be able to commemorate this week, the 782nd anniversary of the signing of Magna Carta, by making my maiden contribution in the House in the name of Runnymede and Weybridge.
Rather more recently, Brooklands, in Weybridge, has been renowned as the home of British motor sport and the birthplace of the British aviation industry. It spawned an engineering industry in the area, which provided an important part of the country's aviation resource during the second world war. It has also created a surprisingly diverse economy in our constituency.
The Brooklands museum is an extraordinary tribute to the men of vision and spirit who built those twin industries on Hugh Locke-King's race-track during the 1920s and 1930s. I strongly recommend hon. Members to take the time to visit that museum when passing through my constituency.
Like people in many similar areas of the home counties, my constituents enjoy the benefits of material prosperity, which are due primarily to our proximity to London and the excellent communications that we enjoy because of the motorway network and Heathrow airport. We also suffer because of that proximity from traffic, noise, pollution and the inexorable pressure for further development. The challenge for my constituency as we move into the new millennium will be to get the balance right. We must achieve the correct balance between continuing prosperity and maintaining the quality of life in the area. That will not be an easy task, but I look forward to playing my part, together with the elected local authorities in the constituency, in achieving it over the years to come.
It will be a pleasure to work with those local authorities, especially Surrey county council, now returned to Conservative control by a substantial majority, and Runnymede borough council, which is also Conservative controlled. Whatever other messages the electors of Surrey may have sent out on 1 May, they clearly voted yes to sound Conservative principles and good management in local government.
Runnymede has the lowest council tax in Surrey while, by general consensus, delivering a high standard of services. It has no statutory obligation to do so, but it is the highest spending authority on services for the elderly in Surrey. Its programme of upgrading and improving council-owned housing stock has the widespread support of tenants. Its private sector partnerships have attracted interest across the country. A key factor in achieving that enviable combination of low council tax and high service provision has been the careful management of its capital receipts. Runnymede is debt-free and it has chosen to invest its capital receipts to produce a substantial income to supplement the council tax for the benefit of all the people of Runnymede.
When the Labour party first promoted the idea of the release of capital receipts, it was presented as some kind of cost-free option. The idea was to take out from under the bed the pot of gold that the wicked Tories had squirrelled away and to spend it to good effect. It is now generally understood that there is no pot of gold. To the extent that set-aside capital receipts are cash-backed, the cash is largely in the wrong places. In public sector borrowing terms, the receipts have already been taken into account. Any increase in the aggregate supplementary credit approvals issued will result in an increase in the public sector borrowing requirement. There is no offsetting effect on the PSBR from any notional release of set-aside capital receipts. There was no mention earlier of the Revenue effects of the increased housing provision that the Government are seeking. If the Government achieve anything by the Bill it will be only by robbing Peter to pay Paul.
The reference in the Bill to capital receipts is a smoke-screen. It does not detail the methodology that will apply in determining the supplementary credit applications. If it is to increase the amount of investment in social housing, it must envisage an increase in the aggregate amount of borrowing by local authorities for that purpose.
The Bill provides a thin cover, through the mechanism of taking total capital receipts into account when determining the supplementary credit approvals, for a transfer of borrowing power from authorities with capital receipts to those without. In many cases, that will mean a transfer of borrowing power from authorities that have managed their housing stock well; taken a forward-looking, innovative approach to housing; and undertaken large-scale voluntary transfers to those that have succeeded in frustrating their tenants' right to buy and which have eschewed the opportunities of the large-scale voluntary transfers that have brought such a welcome diversity to the social housing sector. Incidentally, such transfers have also attracted £4 billion of private sector money, which otherwise would not have been available. The Bill represents the worst kind of subsidy—a subsidy from the efficient to the inefficient.
The implementation of the Bill represents an unjustifiable penalisation of thrifty, well-managed councils such as Runnymede and an erosion of the principle of local autonomy and accountability, which the Government purport to favour. It will also lead directly to the imposition of higher council taxes and higher rents as receipt-rich authorities are forced to run down their balances and forgo the considerable income that those balances currently generate. No less an organisation than Shelter, hardly a well-known supporter of the Conservative view of the world, has calculated that council house rents will rise by £6 a week if all the receipts are released. It is clear that council taxes will rise or services will be cut as prudent councils find that the dice are loaded against them and are forced to liquidate investments.
The Bill is an attack on thrift and good management. It represents a thinly veiled transfer of borrowing power to Labour's friends in local government. I fear that my constituents may expect more of the same when the local government settlement is announced.
The Bill attacks the capital balances of prudent authorities and an attack on their revenue support will not be far behind. It is the new Government's double whammy for the council tax payers of Surrey.
When the Bill is stripped of the smokescreen of capital receipts, it is clear that it paves the way for either an increase in the PSBR or for the reallocation of borrowing power away from receipt-rich authorities. It would be better if it said so plainly without hiding behind the fig leaf of capital receipts. It represents an inefficient way of achieving the Government's legitimate manifesto commitment to higher investment in social housing.
The Bill is unfair in its effect on prudent local authorities. It is lacking in detail. It confers excessive discretion on Ministers. In short, it is an ill-conceived piece of legislation and I urge the House to vote against it on Second Reading.


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CHEYENNE RIVER ELM CREEK
Cheyenne You hear 'Cheyenne' and images of cowboys and rodeos pop in your head. Settled by rugged pioneers following the path of the transcontinental railroad, the capital of Wyoming beckons to you as it did to settlers all those years ago. The quintessential diner on the West Edge of Cheyenne harkens to bygone days. As the regulars will tell you, the core of the restaurant is an old Cheyenne Street Railway Trolley car shell. It carried passengers on the streets of Cheyenne at some point between 18and was repurposed into a diner in Cheyenne TV Series – TV-G 1 h IMDb RATING /10 K YOUR RATING Rate POPULARITY 1, Western After the Civil War, nomadic adventurer Cheyenne Bodie roamed the West looking for fights, bad guys to beat up, and women. His job changed from episode to episode. Stars Clint Walker Clyde Howdy Chuck Hicks.
Interstate 80 Lakes — Grand Island to Elm Creek Island SRA, Cheyenne, West Wood River, War Axe, Windmill SRA, Fort Kearny SRA, Archway Lakes. Cheyenne, North American Plains Indians who spoke an Algonquian language and inhabited the regions around the Platte and Arkansas rivers during the 19th century. Before the Cheyenne lived in what is now central Minnesota, where they farmed, hunted, gathered wild rice, and . Project Period: Cooperators: Cheyenne River Sioux Tribe, U.S. Army Corps of EngineersProject Chief: John Stamm. James River 1 at 16 N, 2 W of Huron off SD 37 Antelope Creek 1 S, 11 E of Fort Pierre off SD Elm Creek at 18 S of Chamberlain off SD Cheyenne is an American Western television series of black-and-white episodes broadcast on ABC from to The show was the first hour-long Western, and was the first hour-long dramatic series of any kind, with continuing characters, to last more than one season. It was also the first series to be made by a major Hollywood film. Beaver Creek are 'steep streams', the Upper Cheyenne River is a 'flat stream', the Belle Fourche River near Elm Springs, South Dakota. Cheyenne is a city located in Laramie County www.saybook.ru is also the county seat of Laramie www.saybook.ru a population of 66,, it is the largest city in Wyoming and the rd largest city in the United States. Cheyenne is currently growing at a rate of % annually and its population has increased by % since the most recent census, which recorded a . Delivery & Pickup Options - reviews of 2 Doors Down "Operated by the owners of Pizzeria Vente (and just 2 doors down from it), 2 Doors Down is a great place to eat if you love hamburgers. They serve a wide variety of tasty burgers with good fries -- and you can substitute a veggie burger for any one of them, a real rarity in Cheyenne -- as well as salmon burgers and some fine salads. In a politically turbulent Mexico full of revolutionaries, Cheyenne encounters a sexy, blond pickpocket singer in Rio Hondo. She arrived on the stage with a local rancher who owes Cheyenne money from a cattle deal and he wants to be paid. S1, Ep13 1 May Star in the Dust () Rate. Delivery & Pickup Options - reviews of 2 Doors Down "Operated by the owners of Pizzeria Vente (and just 2 doors down from it), 2 Doors Down is a great place to eat if you love hamburgers. They serve a wide variety of tasty burgers with good fries -- and you can substitute a veggie burger for any one of them, a real rarity in Cheyenne -- as well as salmon burgers and .
Cheyenne River near Angostura Reservoir (ANGS2) Boxelder Creek at st Ave near Box Elder (BCBS2) Elk Creek (SD) near Elm Springs (ELCS2). Cheyenne is the northern terminus of the extensive Southern Rocky Mountain Front, which extends southward to Albuquerque, New Mexico, and includes the fast-growing Front Range Urban Corridor. [3] [8] Cheyenne is situated on Crow Creek and Dry Creek. Contents 1 History 2 Geography Climate 3 Demographics Ethnicity 4 Arts and culture. Welcome to Cheyenne Wyoming The New Old West Around the world, the very name Cheyenne conjures up images of cowboys, trains, and the great outdoors. Today's Cheyenne is all of that and more! We'll always be here ready to outfit you in new boots and hats from the Wrangler, to point out the Wild-West history in our unique downtown, and to set you front and center at the . Cheyenne, capital (since ) and largest city of Wyoming, U.S., and seat of Laramie county, in the southeastern corner of the state, on Crow Creek, 49 miles (79 km) east of Laramie city; it sprawls over high prairie that slopes westward to the Laramie Mountains. Get river conditions in South Dakota. Cheyenne River Below Angostura Dam, SD · Cheyenne River Near Buffalo Gap, SD Elk Creek Near Elm Springs, SD. Solely represents the Cheyenne River Sioux Tribe and its. Programs and Departments. North Elm Street, Eagle Butte, SD. Lakewood, CO CHEYENNE RIVER RESERVATION. CHEYENNE RIVER SIOUX TRIBE. NAME. PROD. MILES LOC. SHOT. CI F, S. A3. HANDY BOY CREEK 16 F, S. Interstate 80 Lakes — Grand Island to Elm Creek Island SRA, Cheyenne, West Wood River, War Axe, Windmill SRA, Fort Kearny SRA, Archway Lakes. made an www.saybook.ru up the Moreau River as far as Virgin Creek, line on the divide and proceeded west along Elm Creek Valley as far as Arrow Head.
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Cheyenne, English, Plains Sign Talk Religion traditional tribal religion, Native American Church, and Christianity Related ethnic groups Arapaho, Blackfoot, Suhtai, and other Algonquian peoples The Cheyenne (/ ʃaɪˈæn / shy-AN) are an Indigenous people of the Great Plains. Their Cheyenne language belongs to the Algonquian language family. Cheyenne River and certain tributaries' uses. West Fork Lac Qui Parle River, also known as Gary Creek West Fork Elm Creek. IRR County Road over Elm Creek, Open to traffic, Pony truss, , --, , Four Corners Bridge, Four Corners Road over Cheyenne River. Similar Homes For Sale Near Adrian, MI. Comparison of Cheyenne River Dr, Adrian, MI with Nearby Homes: Photo of property at Elm St, Adrian. scramblingbadger. Score: % Views: Elk Creek Canyon Closeup Score: % Views: Cheyenne River Canyon Area Elm Creek Canyon Rock. Cheyenne (TV Series –) cast and crew credits, including actors, actresses, directors, writers and more. Menu. Trending. Top Movies Most Popular Movies Top TV Shows Most Popular TV Shows Most Popular Video Games Most Popular Music Videos Most Popular Podcasts. Movies. Cheyenne, North American Plains Indians who spoke an Algonquian language and inhabited the regions around the Platte and Arkansas rivers during the 19th century. Before the Cheyenne lived in what is now central Minnesota, where they farmed, hunted, gathered wild rice, and made pottery. They later occupied a village of earth lodges on the Cheyenne River in .
The Cheyenne (/ ʃaɪˈæn / shy-AN) are an Indigenous people of the Great Plains. Their Cheyenne language belongs to the Algonquian language family. Today, the Cheyenne people are split into two federally recognized nations: the Southern Cheyenne, who are enrolled in the Cheyenne and Arapaho Tribes in Oklahoma, and the Northern Cheyenne, who. Badger Park housing subdivision located on the Cheyenne River Reservation, Lightning, Bear Creek, and in Eagle Butte at the CRST Tribal Wellness Center. Cheyenne TV Series – TV-G 1 h IMDb RATING /10 K YOUR RATING Rate POPULARITY 1, Western After the Civil War, nomadic adventurer Cheyenne Bodie roamed the West looking for fights, bad guys to beat up, and women. His job changed from episode to episode. Stars Clint Walker Clyde Howdy Chuck Hicks. Red Elm. Promise. LaPlante. Ridgeview. Swiftbird. Blackfoot. Glencross Cheyenne River Sioux Reservation to hunt, fish or trap without the appropriate. director of the Office of Tribal Relations and a member of the Cheyenne River Sioux tribe. Great River Energy Elm Creek Boulevard Maple Grove. SD NE ; Avg (inches) Entire Basin::CHEYENNE RIVER AT EAGLE BUTTE SD CREEK NR MITCHELL SD NE ; Avg (inches) Entire Basin::ELM RIVER. Have a definition for Elm Creek (Rio Grande River)? Write it here to share it with the entire community. Add Definition.

redpajama_set_name: RedPajamaCommonCrawl


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Learn about black women in history through black history movies. These are a few movies that feature historical documentaries of the lives of Black and African-American women in history.
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In addition to the list of segregation movies on Netflix, these segregation movies feature historical documentaries surrounding the trials of Black and African-American people during the 1960s.
These slavery movies feature historical documentaries surrounding the trials of Black and African-American people during slavery in the 17th and 18th centuries. There are also several slavery movies on Netflix.


Buildings including our residential homes or structures in our places of work comprise of different things including the windows. These pieces are usually made by combining the wooden or steel frames with the glass panes. Joined with the help of hinges and screws etc, good windows help the humans to have fresh air, sunlight and also a glimpse of the exteriors. As such we must buy good pieces for which services of windows Harrow or other prominent entities are often hired by the needy guys.
Exact needs – First of all, make a list of the places where you intend to get the new windows installed. It would be helpful in apprising the manufacturer or vendor to make available suitable pieces. Check if the company is able to fulfil your exact needs with regard to the number of required windows.
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Villa Lucilia is a palatial-style holiday home close to the town of Calpe on the Costa Blanca. With unobstructed views of the sea from many rooms and the extensive grounds, Villa Lucilia commands a privileged position within a quiet neighbourhood.
The luxurious look and feel of this villa can be enjoyed both inside and out, with beautifully furnished rooms to the interior and a stunning outside area.
Set over three levels, the accommodation at Villa Lucilia is comfortable and full of modern conveniences. As soon as you step inside and enter the hall, you're greeted with a sense of grandeur. There are a sofa and coffee table for sitting and taking in the views offered by patio doors that open onto a terrace.
By these doors is a space with a small dining table and a beautiful fireplace for enjoying cosy evening meals when it's chilly outside. The contemporary living room is a vast, chic space. It's home to three sofas that are positioned around a large flat screen television and a suspended wood-burning stove that acts as a stunning focal point.
The well-equipped kitchen is also the right size and has both a small breakfast bar and table for flexible eating options. Patio doors lead out to a balcony terrace with outdoor furniture for taking your meals outside.
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The outside space is simply breathtaking regarding its features, facilities and views. As well as the many smaller terraces around the exterior of the villa, there's also one large main terrace.
Here you will find a beautiful lagoon-shaped swimming pool with a selection of sun loungers sitting alongside it. The gardens surrounding the pool are full of exotic trees and plants, making it feel like a secret paradise. A separate building mimics the grand style of the villa, with nods to ancient Greece and Rome throughout its pillars and temple-like structure.
Under its partially-covered terrace are a large dining table and an outdoor kitchen with built-in barbecue, giving you the chance to dine like emperors!
Situated within a residential area close to the heart of Calpe, Villa Lucilia is ideally located for amenities and places to go for days out.
The seaside town of Calpe is just 2 km away and offers streets full of history and culture. Gothic churches and Roman ruins are just some of the fascinating points of interest to visit in Calpe.
Head down to the town's marina for some lunch after a morning of sightseeing. There's a great choice of restaurants on offer here, and most serve a variety of fresh fish and seafood dishes.
Having several sandy stretches to its name, the main beach of Calpe is Playa de la Fossa. With a long promenade full of shops, bars and restaurants, you don't have to go far to grab some ice creams for the whole family or enjoy a delicious lunch at a traditional restaurant.
The coastal parts of Calpe are dominated by Penyal d'Ifac, a massive limestone rock that rises out of the sea. A natural park in itself, it's home to hundreds of animal species and many rare plants. If you're feeling energetic, hike to the top of the rock and marvel at the stunning views over the town and sea.
Altea is approximately 30 km away from the villa and is another coastal town that has managed to retain much of its traditional Spanish charm. The old town is nestled on a hillside, and its cobbled streets are lined with traditional restaurants and shops selling beautiful handmade goods.
The famous blue-domed church of the Virgin de Consuelo sits at the top of the old town area and offers fantastic views down over the bay.
Villa Lucilia is a fantastic holiday home for families with children. Everyone will love the amount of space inside the villa and the friendly areas for getting together.
The outside area is like a playground, with the outdoor kitchen and barbecue building being the perfect place to let their imaginations go wild. They'll also love playing in the pool and with the table tennis table.
Head to Terra Mítica in Benidorm to enjoy a thrilling day out. This fun-filled theme and adventure park are only 30 minutes away from the villa by car, and it'll keep the children entertained for hours.
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Stacker2 Europe has been well known for over 15 years as the producer of the most powerful sports nutrition. Every product is meticulously composed and tested for effectiveness in consultation with top athletes. Only the best and most efficacious ingredients are used. This also applies to our latest pre-workout: INFERNO.
INFERNO sets the bar several notches higher during your training session. 15 minutes after taking INFERNO, you can feel the energy flowing through your entire body. Your inner fire blazes. There is no way back. Your body demands that you take on that punishing training session to get rid of the energy. At the gym you hunger for more sets, heavier weights and a more demanding training schedule.


text:
Caratteristiche tecniche
È un mediano.

Carriera

Nazionale
Ex capitano dell'Under-21 slovacca, ha giocato anche le Olimpiadi 2000 da capitano dell'Under-23.

Esordisce il 6 febbraio 2002 contro la Nazionale iraniana (2-3).

Collegamenti esterni

Calciatori della Nazionale slovacca

redpajama_set_name: RedPajamaWikipedia


text:
Q: when to use show Segues & when to use Show detail Segues I am new to IOS Development and I am confused between when to use show segue & when to use Show detail segue. Both them are used in the default master-detail project.
So when do we use either of them? What is the best case to use show segue & when to use show detail segue?

A: Show segue can be used with navigation controllers, they simply push viewControllers on your stack.
Show detail segue has only sense with split view controllers. Since you have two viewControllers inside your split view controller you can:

*

*navigate in your master view controller by presenting (pushing, since the default project uses a navigationVC as master VC) view controllers with Show segue

*show details in your detail view controller with Show detail segue
In case you don't know how a Split view controller is composed:
**************++++++++++++++++++
*            *                 +
*            *                 +
*   master   *      detail     +
*    view    *       view      +
* controller *    controller   +
*            *                 +
*            *                 +
**************++++++++++++++++++

BUT !
On iphones it's presented like this (iPhone6+ landscape excluded)
****************
*++++++++++++++*
*+            +*
*+            +*
*+            +*
*+   detail   +*
*+    view    +*
*+ controller +*
*+            +*
*+            +*
*++++++++++++++*
****************

Both of Show segueand Show detail segue are new to iOS8 & Xcode6, they are called adaptative segues, they behaves differently depending on the device type or the orientation.
Basically, Show segueand Show detail segue seems to do the same thing on iPhones, since there is no much space to present view controllers side by side.
Technically, you don't present details several times until you go back in your navigation. Only the master view controller should perform Show detail segues, a detail view controller should be a leaf in your navigation tree (but it's not forbidden to use a navigationVC as a leaf ;) )
Hope it helps.

redpajama_set_name: RedPajamaStackExchange


The Australian-flagged MV Tomin was detained in the Port of Yamba, New South Wales, on June 25 after Australian Maritime Safety Authority (AMSA) inspectors found the vessel to be unseaworthy, substandard and a threat to the marine environment.
With support from New South Wales Police, the owners of the vessel were arrested on board and have been charged with offences under the Navigation Act.
AMSA inspectors found what appeared to be structural leaks and oily waste inside the vessel, as well as information suggesting the vessel undertook a voyage to Australia from the Solomon Islands without required certification.
AMSA notes that the International Convention for the Prevention of Pollution from Ships (MARPOL) applies to all ships on international voyages. Section 135 of the Commonwealth Navigation Act provides that it is an offence for an owner to take a vessel to sea, or cause or permit another person to take the vessel to sea, unless the vessel has been certified to comply with applicable provisions of MARPOL. The offence carries a maximum penalty of 10 years imprisonment or a fine of $126,000 or both.


During the retirement process, you designated a beneficiary for your SFERS Plan to ensure a benefit is paid to the intended recipient upon your death.
To update your beneficiary information, download, complete, and submit a new SFERS Designation of Beneficiary Form. Please have the form notarized if submitted to our office by mail.
If you are submitting the form in person, visit the SFERS office at 1145 Market Street, 5th Floor, between 8:00 am and 4:30 pm Monday through Friday. Bring your picture ID (e.g. Driver's License) and sign the form in the presence of a SFERS employee to witness your signature (the form does not need to be notarized if submitted in person). An appointment is not required to update beneficiary information.


Mark Watson's artificial intelligence and machine learning blog: Is it better to spend time learning new programming languages or study languages and tools you already use?
Is it better to spend time learning new programming languages or study languages and tools you already use?
I have been thinking about a discusion on Hacker News yesterday about which new programming language people want (or need) to learn. While I definitely enjoy learning new programming languages by writing small applications, I think that I personally get a better productivity boost by reviewing languages and tools I already use.
In the last year I have mostly used Ruby and Clojure for my work. In the last few months I have read two books on Clojure and one on Ruby. Sort of: the more you know, the more you can learn and more deeply understand something.
Recently I reviewed the commands and read another tutorial for the screen utility that I have been using almost everyday for three years. Well worth the time.
I do a lot of work on remote servers and emacs is not always installed so I have also used vi for years. This morning, I saw a reference to learning vim by using vimtutor and spend 20 minutes working through the complete tutor program (learn by doing: you edit the tutorial as part of the tutorial). Time very well spent.


Prime Minister Narendra Modi evidently scored a point with the support he lent the Armed Forces Special Powers Act (AFSPA) even as the Congress manifesto calls for a review of it in Jammu and Kashmir. Modi told Network18 removing AFSPA is like 'sending our soldiers to the gallows' and the BJP would never do that. This will largely sit well with the Indian Armed Forces. But how effective is the AFSPA in its current form? Does it give cover to our soldiers? This question demands an answer beyond the BJP-Congress rhetoric.
In this era of fake news, the brouhaha reached a crescendo with a story going viral about how Indian soldiers were sent to jail — at the behest of former Jammu and Kashmir chief minister Mehbooba Mufti — simply for having stopped a civilian vehicle at a barricade. This fake news became the symbol of everything that is wrong with hobbling our men in what is essentially a battle zone.
The echo of the lie that masquerades as the truth is something we have learnt to live with. The more important question to ask is this: Does AFSPA actually give the men in the firing line legal cover?
1: After giving such due warning, fire upon or use other kinds of force even if it causes death, against the person who is acting against law or order in the disturbed area for the maintenance of public order.
2: Destroy any arms dump, hide-outs, prepared or fortified position or shelter or training camp from which armed attacks are made by the armed volunteers or armed gangs or absconders wanted for any offence.
3: To arrest without a warrant anyone who has committed cognisable offences or is reasonably suspected of having done so and may use force if needed for the arrest.
4: To enter and search any premise in order to make such arrests, or to recover any person wrongfully restrained or any arms, ammunition or explosive substances and seize it.
5: Stop and search any vehicle or vessel reasonably suspected to be carrying such person or weapons.
6: Any person arrested and taken into custody under this Act shall be made present over to the officer in-charge of the nearest police station with least possible delay, together with a report of the circumstances occasioning the arrest.
But now, every one of these actions can trigger judicial probes and reports against soldiers that would have them confined to barracks or worse, arrested on charges of violence, torture, assault and molestation. And in every such case, give the local police powers that render null and void the soldier's initiative.
Consequently, Modi's indignation over the Congress shortsightedness and myopic vision is slightly skewed by the general feeling in the forces that they are collectively and singly vulnerable to legal prosecution while carrying out their duties and that the human factors of fear, self-preservation and search for safety in the face of death by violence has been disregarded.
In this context, the Major Gogoi case leaps centre stage. In April 2017, to escape stone-pelters and save his squad, Gogoi tied a local — Farooq Ahmad Dar — to the bonnet of his official vehicle and used him as a human shield in the Beerwah area of central Kashmir's Budgam district. Dar is seeking legal justice for this act of torture.
In a post-op situation or one where you are under threat of life or are confronting elements who have just killed your mates and would happily kill you (that being their singular intent) the one proviso the AFSPA should satisfy is that soldiers expect their nation to have their backs and not have to watch their back from their nation and government.
There is no right way to behave when someone is carving your name on a bullet.


text:
WATER DISCOVERY
PROJECT EXPERIENCES
LUNI RICERCHE S.R.L.
" His abilities are extraordinary. He seems to be able to see through the earth with his hands."
" He found water for us in places where we had nearly given up after long and expensive searches. I remember a spot where our company sought water since 1906, using all possible technology to no avail. After only two days of walking the area, Maurizio discovered a rich vein of water and told us exactly how far down the water was." "Thanks to his gift, we were able to save millions of dollars"
Vittorio Arbasino,
head of research at ITALGAS,
Italian state-run natural gas company
The following testimony demonstrates, such as moving only a few feet from failed drilling without water, we can instead find a rich aquifer. Often, since recognized expert in the field of water research, I was called where the others had failed, like in the case of the Company ITALGAS which operates the aqueduct of Rapallo, where I discovered a huge underground aquifer where the other researchers had in succession always failed water search for nearly a century (85 years).
The film director, Fabrizio Cattani, was inspired, for his film "The Diviner", by the special technique of Maurizio Armanetti and said:
"His name is Maurizio Armanetti, I think he's the most famous dowser in Italy. He even managed to find in the valley of Tigulio, in Liguria, a large water reservoir where instead a group of geologists had tried without success. Maurizio has fascinated me his way of seeing things, of estrangement from the matter to search on a quasi-shamanic spirituality. The most beautiful idea he gave me is the one of the hands. When he is searching for water, moving on the ground, making moving his hands from the top down , at the height of the belly. I found this technique to search water very cinematic and I played on the screen."
The professional activity of Maurizio Armanetti is cited in the following books:
Water trasparent gold
This book stems from the humanitarian exigency of the authors to transmit the incisors conclusions of an International Symposium of the Association of Orthomolecular Medicine (A.I.M.O.) during which were faced possible solutions regarding the emergency "water"…humanitarian exigency of the authors to transmit the incisors conclusions of an International Symposium of the Association of Orthomolecular Medicine (A.I.M.O.) during which were faced possible solutions regarding the emergency "water"…
"… the use of the brain as an instrument of perception, but in addition to this ability to use the body as an instrument, you can also feel those biophysical feelings already described …"
" In Italy we have two brilliant and enthusiastic researchers and through them we had the introduction and diffusion of Organic Architecture: Gianfranco Carignano and Maurizio Armanetti."


text:
← Barry Trower on Wi Fi Radiation: "We Are Risking the Future Generations of All the Children in the World"
Dr. Mercola Interviews Alasdair Philips: EMF's Effect on Health: What the Research is Showing and What We can Do To Limit Radiation Exposure From Wireless Devices →
The website 5GWiFi, set up by Irvine-based Broadcom, offers a "primer" on the new IEEE 802.11 ac or "5G" Wi Fi chip. Scroll down to the "technical details" to read about the RF spectrum and "beamforming." Note: Be prepared when reading industry ads to be transported "kidlike" back to Superman watching days: This chip will allow people to be "on the move," taking their devices wherever they please to form "ad-hoc" work groups. It will improve, they say, "connectivity," opening up a whole new "freeway" with lots of driving room ("wide lanes") for one's data and an ability with the "beamforming" capacity to avoid "potholes," and penetrate surfaces heretofore impermeable to Wi-Fi such as concrete:
"Many factors affect the coverage area of a network—most notably, the way a structure is built. Concrete walls, ceramic bathroom tile, and metal appliances are more difficult for Wi-Fi signals to penetrate, in contrast to wooden walls with gypsum board, which are easier to penetrate. But signals from IEEE 802.11ac networks, with beamforming and other innovations, do a much better job in penetrating all forms of building materials than do the signals from its predecessor networks. In fact, the ability of IEEE 802.11ac signals to transmit through some concrete walls is expected to help homes in India and China, where concrete is used extensively as a construction material."
One can get so swept away reading industry ads, that it may only occur later, when one is scrubbing the kitchen sink, the window slider open even though it is a gray day and they are predicting rain, that the ability of these new chips to penetrate concrete, ceramic and metal means that along with all the "exciting" new features the new 5G WiFi chip is "offering," it will also be disrespecting our boundaries and invading our personal spaces: the walls of our homes, the skin which separates our bodies from the air around us; and, as the IARC WHO "Working Group" wrote in its discussion of EMF's in The Lancet Oncology , it will, in fact, "couple" with our bodies "resulting in induced electric and magnetic fields and associated currents inside tissues"; and people who want to shield from this radiation will have a lot more difficulty.
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text:
A Cappella Books
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An Abraham Lincoln Tribute: Featuring Woodcuts by Charles Turzak
Dover Publications, January 2009. Hardcover. Used - Very Good / Very Good. Item #221790
From a humble backwoods cabin to the highest office in the land, this graphic art biography chronicles Abraham Lincoln's path from obscurity to immortality. Its thirty-six striking woodcuts, each accompanied by a brief caption, depict scenes from the life of the sixteenth president. Original and imaginative in their stark beauty, these images offer fresh perspectives on the familiar tale of Lincoln's progress from rail-splitter and self-taught prairie lawyer to his role as the Great Emancipator and preserver of the Union.
This new edition of Charles Turzak's remarkable book is presented in commemoration of the bicentennial of Lincoln's birth. In addition to a new preface and introduction, it features an appendix with several of Lincoln's famous speeches, letters, and quotations. A keepsake treasure for Civil War buffs and historians, this unique expression of American culture will inspire readers of all ages.
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text:
Q: How to know which JMS listener listen message from queue? I have configured jms queue where multiple listeners are listening to same queue and if i push multiple objects into my queue which listener going to get the messages? is there any guarantee that to know which listener listen my message?

A: Did you custom code the listeners? If so, just add some code to generate a unique id for each listener, save the id in an instance variable. When the listener gets a message, output the event with the id to standard log file.
public class MyListener extends MessageListener {

    private static int listeners;
    private int id;

    public MyListener(){
      this.id = generateUniqueId();
    }

    public void onMessage(Message m){
      System.out.println("Listener " + id + " got message!");
      //do stuff here
    }

    private synchronized static int generateUniqueId(){
        return listeners += 1;
    }
  }

A: Hi user2336442 (nice name by the way...),
if two receivers listen on the same queue there's no guarantee about which one of them will receive the message first, since they follow the principle first-come first-served. If the two listeners are on the same machine (same ip addresses) there's no way to understand which one received the message, otherwise you can use the console to roughly see where the messages have been sent...


text:
Hero Collector Launches Trio of New Star Trek Books, Including Star Trek: The Original Series — A Celebration
NEW YORK, Aug. 30, 2021 /PRNewswire/ — Hero Collector, the publishing division of Eaglemoss, continues to boldly go to the final frontier, beaming Star Trek fans a trio of exciting new books. Star Trek: The Original Series – A Celebration will arrive on September 21, following on the heels of the August releases Star Trek Shipyards: Starfleet Ships 2294-The Future (Updated and Expanded) and Star Trek: Designing Starships – Deep Space 9 and Beyond.
The cover of Star Trek: The Original Series — A Celebration, written by Ben Robinson and Ian Spelling, available from Hero Collector.
Star Trek – A Celebration is the ultimate guide to the making of the Star Trek that started it all. Written by Ben Robinson and Ian Spelling, Star Trek – A Celebration's 256 pages are filled with brand-new and archival conversations, and 200-plus photos and sketches, many rarely seen or never-before-seen, that shine a fresh light on the actors, writers, directors, production and costume designers, composers, prop builders, visual effects and makeup artists, and more, who brought Star Trek to life. A Celebration also pays tribute to the fans who campaigned to save the show, looks back at the earliest Trek conventions, and breaks down 12 key episodes.
"Our goal was to craft a book that was the written and visual equivalent of a great convention," Spelling says. "We've brought fresh eyes to everything and tried to strip the myths away from the reality and, we've discovered new stories that haven't been told." Adds Robinson, "We also tracked down some incredibly rare pictures and artwork that have never been printed before. However well you think you know Star Trek, there's something new for you. It's really the Star Trek book I've always wanted to add to my collection."
Star Trek Starships: 2294-The Future, edited by Ben Robinson and Marcus Riley, presents a chronological history of Star Trek's Starfleet starships, from the 24th century to the far future. This in-depth reference book shines a spotlight on such vessels as the U.S.S. Enterprise NCC-1701-D, U.S.S. Voyager, and Starfleet's first true warship, the U.S.S. Defiant. Fans can also explore several time-traveling ships, among them the U.S.S. Enterprise-J, and the U.S.S. Nog. All of the ships are illustrated with CG artwork, including original VFX models crafted for the shows.
The inventive concept art behind Star Trek: Deep Space Nine's titular space station, as well as the U.S.S. Defiant, and dozens more ships from other Star Trek series and movies come to life on the pages of Star Trek – Designing Starships: Deep Space 9 And Beyond. Edited by Ben Robinson, the book delivers original production art and extensive interviews with the award-wining concept artists who created the ships for The Original Series through the TOS and The Next Generation movies to Enterprise.
Star Trek – A Celebration is priced at $34.95/U.S. and $44.95/Canada. It's available for pre-order at www.penguinrandomhouse.com. Star Trek Starships 2294-The Future (Updated and Expanded) and Designing Starships: Deep Space 9 and are each priced at $34.95 in the U.S. and $44.95 in Canada. They're available now at www.penguinrandomhouse.com.
Ian Spelling
SOURCE Hero Collector


He's a recent High School graduate; he was probably an average student, pursued some form of sport activities, drives a ten year old jalopy and has a steady girlfriend that either broke up with him when he left or swears to be waiting when he returns from half a world away He listens to rock and roll or hip-hop or rap or jazz or swing and a 155mm howitzer.
He is 10 to 15 pounds lighter now than when he was at home because he is working or fighting from before dawn to well after dusk. He has trouble spelling; thus letter writing is a pain for him. He can field strip a rifle in 30 seconds and re-assemble it in less time in the dark. He can recite to you the nomenclature of a machine gun or grenade launcher and use either one effectively if he must.
He has two sets of fatigues; he washes one and wears the other. He keeps his canteens full and his feet dry.
He sometimes forgets to brush his teeth but never to clean his rifle. He can cook his own meals, mend his own clothes and fix his own hurts.
He feels every note of the National Anthem vibrate through his body while at rigid attention, while tempering the burning desire to 'square-away ' those around him who haven't bothered to stand, remove their hat or even stop talking.
He has asked nothing in return except our friendship and understanding.
As you go to bed tonight, remember this shot. . .
This came to me through my email from a very dear lady whose husband is a veteran.
Remember these faces. They could be the faces of the boys and girls you watched grow up–except now they are men and women. They are doing a thankless job, due to our traitorous MSM and such seditious and subversive groups as Code Pink, such idiots as Nancy Pelosi thanking Iran for the surge working rather than these men and women, and such moronic head cases as Cindy Sheehan. These are the faces of the men and women who give these traitors their rights–and are spit on, denigrated, called names, disrespected at every turn and, often, who lose their lives due to the actions of the lunatic fringe and those like them by vital information being given to the enemy.
Remember these faces. They are loved and they are protecting YOU and me and our loved ones. Pray for them and their families. And when you see one of them or their sisters and brothers, thank them–and be sincere. Were it not for such raw courage, where would this country be? Were it not for these men and women doing their jobs, and doing them very well indeed, what shackles would US citizens be living under? They fight and bleed, sweat and die for us and our way of life, our freedoms.
Remember these faces. Don't ever, EVER take them for granted.


text:
Pseudocnus grubii is een zeekomkommer uit de familie Cucumariidae.

De wetenschappelijke naam van de soort werd in 1874 gepubliceerd door Emil von Marenzeller.

Zeekomkommers


Recently, I've become attracted to a guy who manages a gay sauna in my local area.
I asked him if he wanted to go out for a drink, he was very unenthusiastic, made the excuse that he was very busy.
When I suggested the following week, he just said maybe and told me to call him.
What seems weird to me is that prior to me asking him out, he has always been very flirty and friendly towards me, to the point that I'm certain that he's attracted to me as much as I am to him.
He always goes out of his way to talk to me and even gave me a free entry voucher to his sauna.
Plus told me he manages another sauna across town and said if I was ever in the area to come and say hi.
I really like him, do you think he is playing hard to get, is cautious of going out with one of his customers or am I just misreading his attraction?
How can I find out if he likes me? I don't know whether to ask him out again or just give up. What's your advice?
It looks like you tried, but he just gave you excuses not to go out with you.
He may be very friendly because he owns a business and he wants customers to come back.
If you are good at customer service, you give your customer full attention and make him feel special.
In other words, he may not be attracted to you at all. It may just be business.
The only way to know for sure is to ask him out again.
This time tell him how you feel about him and see what he says.


text:
Q: Has my book an errata or is my calculus wrong when differentiating $x^{2} = 2y^{2}\log{y}$ In "Differential Equations with Applications and Historical Notes" there is a calculus problem at the very beggining that ask you to verify that:
If $x^{2} = 2y^{2}\log{y}$ then $y' = xy/x^{2} + y^{2}$
My differentiation is as follows:
$$
x^{2} = 2y^{2}\log{y}\\
2x = 4yy'\log{y} + 2y^{2}\frac{y'}{y} \\
2x = y' (4y\log{y} + 2y^{2}\frac{1}{y}) \\
y' = \frac{2x}{4y\log{y} + 2y} = \frac{x}{2y\log{y}+y} \\
y' = \frac{x}{2y\log{y}+y}\frac{y}{y} = \frac{xy}{2y^{2}\log{y}+y^{2}} \\
y' = \frac{xy}{x^{2}+y^{2}} \neq xy/x^{2} + y^{2}
$$
Clould it be an errata? Thank you in advance.


Not everyone knows just how much work the Chamber Executive team get through on behalf of our members to ensure we have the best possible representation and influence regarding developments within our town and the County.
August is traditionally a holiday month but we have continued to present your views on the Joint Core Strategy (proposals for new housing and business premises in Cheltenham for the next 20 years), the Gloucestershire LEP (major infrastructure schemes for the County) and the Cheltenham Development Partnership (the regeneration of Cheltenham Town centre). Specifically this month we have challenged the Borough Council's plans for up to 650 new dwellings in Leckhampton, where the A46 is already near capacity in highly valued greenbelt.


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For two years I pursued wellness through healthy eating, as outlined by naturopathic tradition and emphasized with little change in the health food literature of today.
This program seeks to provide new opportunities as well as stay up to date with more traditional career paths. Inthe Paris pastry guild was recognized and started to expand their product—and so something like the modern day crust began to be used. Add on top of that the fact that these three-dimensional wads of meat would have to be exercised regularly with stretching machinery, essentially elaborate meat gyms, and you can begin to understand the incredible challenge of scaling in vitro meat.
Ours attracted food idealists. Each ingredient has been specifically selected for a host of reasons and replacing one for another can have numerous consequences. Fasting on oranges is healthy.
In this vision of the future, our steaks are grown in vats rather than in cows, with layers of cow cells nurtured on complex machinery to create a cruelty-free, sustainable meat alternative.
If it continues after this, the food will not be overcooked, and it will not cook more after it stops being heated. This 'pastry' cover was not meant to be eaten and was thrown away.
He is a testament to the health destroying properties of milk. A long, inflexible pipe is shoved down their throats three times a day and several pounds of feed are pumped into their stomachs, causing their livers to become diseased and swollen.
Choose the solution that fits you the best, but the final choice is in your hands.
The flavors and 'crust' texture developed by browning are generally seen as very desirable in the cooking of certain types of meat, such as a steak. Pasteurized milk is even worse. They believed onion-family foods provoked sexual desire. Wild salmon also has the benefit of being very high in vitamin D.
As early as live cattle were driven to Boston, where they commanded high prices The etymology of the word is unknown, but may be related to the magpie also called "pie"perhaps because both were spotted, or because the bird collects miscellaneous articles.
Each food would come complete with a citation from one system or authority claiming it the most divine edible ever created, and another, from an opposing view, damning it as the worst pestilence one human being ever fed to another. Makes 6 burritos Even though there are only 9 ingredients in the burritos there are several different ways to prepare them.
These movements occurred on a prodigious scale, hardly comparable to the placid processions of fifty or a hundred head which had earlier moved north from Georgia or east from Ohio Vitamin D was an extremely tricky vitamin to get into the Ultimate Burrito and it highlights how we live in a world of tradeoffs and tough decisions.
Other well known varieties of meat pie include British meat piesFrench-Canadian meat pieand the Australia and NZ meat pie. The first occurred when my guru in eating, a lacto-ovo-vegetarian headed on his way toward Fruitarianism, suddenly abandoned his quest.
Until you change your policies about this, please remove my name from your mailing list".
I abhor animal experimentation with my whole soul. We all know calcium is needed for strong, healthy bones and it is no surprise that dairy products like cheese have lots of it. Thank you for reading this.
In this vision of the future, our steaks are grown in vats rather than in cows, with layers of cow cells nurtured on complex machinery to create a cruelty-free, sustainable meat alternative. Study the puffy skin of his face.
Nevertheless as early asHarper's Weekly reported that the commonest meal in America, from coast to coast, was steak; and at the beginning of the Civil War, Anthony Trollope Grant funding will assist in the purchase of equipment to develop this community business.
All I could think about was food. Empanada dough takes many forms, from those made with cornmeal to puff pastry.Several weeks ago, New York Times columnist Ariel Kaminer created a contest asking people to argue that eating meat is an ethical decision.
Kaminer was pleased by the response. Judges included carnivores, vegetarians, and perhaps the most thoughtful and compelling vegan living, Peter Singer (and it. Shop new, used, rare, and out-of-print books. Powell's is an independent bookstore based in Portland, Oregon.
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Mobile learning is any sort of learning that happens when the learner is not at a fixed, predetermined location or learning that happens when the learner takes advantage of the learning opportunities offered by mobile technologies.
These technologies make a user mobile examples are Mobile phones, notebooks, laptops, PDAs etc. Limitations of learning as in everywhere are overcome by using m-learning as it provides mobility through the use of portable mobile devices.


A female was the victim of an assault with a deadly weapon — a skateboard — on Saturday.
At about 11:30 p.m., the victim and a friend were walking on Frank Schlessinger Way near Haas Pavilion when a nearby skateboarder threw a skateboard at her for unknown reasons, according to a UCPD crime alert released Monday.
The victim received an arm injury, and the skateboarder fled on the skateboard, heading westbound on Frank Schlessinger Way.
The victim was then transported to Alta Bates Summit Medical Center for treatment.
According to the crime alert, the perpetrator is described as a white male, 20 to 30 years old and wearing a T-shirt and light-colored cargo pants.


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How McLaren found the right formula for F1 success with Splunk
By Chris Middleton January 18, 2023 Audio mode
Motor racing legend McLaren and its data analysis partner Splunk discuss how they make cars go faster – in both the real and virtual worlds
(Image sourced via McLaren)
British Formula One and automotive giant McLaren is celebrating three years of its partnership with US machine data specialist, Splunk. But why is such a relationship so important in a world that, on the face of it, is all about speed, engineering excellence, and driver skill?
The answer is that F1 is no longer just about the physical realm, where data is critical, but also about its virtual and simulated counterparts. In all these environments, racing generates a phenomenal amount of data about a car's performance on the track in all weather conditions, which can lead to race-winning decisions and improvements.
In a market that is the definition of fast moving – not just car speeds of over 200mph, but also constantly changing regulations and technologies, plus new safety and sustainability/circularity demands – even marginal improvements can mean the difference between being first or last on the grid.
As a result, today's physical F1 cars are packed with sensors, monitoring every aspect of these fine-tuned, multimillion-dollar machines. James Hodge is GVP and Chief Strategy Advisor for Splunk. He says:
On the real racing cars there are initially about 300 sensors, but that gets reduced down to about 120 over free practice, qualifying, and the race, because of weight. And because they won't do anything in real time with a lot of that data during the race. You only keep a sensor on if you're going to make it actionable.
Ed Green is Head of Commercial Technology at McLaren. He explains:
We were one of the first teams to run sensors on cars. We started out with, say, 20 monitoring low-level telemetry, maybe temperature or pressures. And now up to 300 measure everything from air pressure all the way through to gearbox temperatures and ride height.
And from those 300 channels of data – some are reading at 10 hertz, and others at 60 to 80 hertz – you can synthesize data together and start getting data points that you're not physically measuring yourself.
Throughout McLaren's history, we've pioneered and led the way in this, and that's inspired work across other industries as well. But it's also really helped us to go fast!
This sport has got such fine margins – a percentage-point difference between first and last positions on the grid. Sometimes that's seconds, but sometimes it's hundredths between lap times, or milliseconds. In a world like that, you've got to use tech and you've got to use data to help you see the way forward and how you're going to improve.
But at some point, might the laws of physics intervene, and it will no longer be possible to make a car go faster on a given track? Green says:
That's a really good question. I'd say no, because there are so many regulations. Two years ago, the aerodynamics of the Formula One car were designed to push the car into the road. But this year, we had a regulation change, which means we've now got to suck the cars onto the road, in effect. So, might we one day come up against the laws of physics? Maybe, but only in a totally unregulated world!
In the 21st Century, these issues increasingly apply in simulations and in competitive esports just as much as they do on the tarmac at Grands Prix, with major F1 brands having a presence in all these realms and more. Indeed, it could be argued that physical events are almost becoming brand ambassadors for their virtual, esports counterparts, which attract millions of fans from a broad gaming demographic.
McLaren – winner of 12 physical drivers' championships and eight constructors' titles since 1974, after debuting at the 1966 Monaco Grand Prix – has been a prime mover in all these spaces. For example, while McLaren Racing came fifth in the real-world Constructors Championship in 2022, the McLaren Shadow team is the reigning Formula One Esports champion, the virtual racing series that launched in 2017.
Lindsey Eckhouse is McLaren Director of Licensing and Digital Products. She says:
What is unique about F1 Esports, as opposed to other esports, is how similar it is to the real-life product, to Formula One. There are a lot of shared insights and shared experiences, plus a shared approach, or one that we can shadow. That's where the name McLaren Shadow comes from.
And that's why a partner like Splunk, who partner with the Formula One team and offer a variety of technical solutions to them, are critical to us as an F1 Esports team as well. As with McLaren Racing, we take Splunk's Data to Everything platform, with custom dashboards, and are able to analyze real-time data that ultimately improves our F1 Esports performance.
The Woking, Surrey-based automotive company began its partnership with the San Francisco-based machine-data specialist just before the pandemic hit. COVID not only shut real-world events for an extended period, of course, but also caused a spike in popularity for F1's esports counterpart.
Today, Splunk is the bigger company, with revenues of $2.67 billion against the $771 million of the McLaren Group (of which McLaren Racing is a subsidiary). Proof that even in the heady, big-money world of F1 racing, data is now the real money-spinner.
So how linked are real-world F1 racing and esports from a technology perspective?
In a sense, the F1 simulator rigs are the bridge between the real and virtual environments. F1's star drivers increasingly train in these simulators – combinations of the virtual and the modelled physical worlds – before taking the new season's car out on a physical track. Terabytes of data might be gathered from simulated laps on the globe's most challenging circuits, information that could save the driver's life in the real world, as well as win races.
McLaren's Green adds:
What's amazing is when drivers join the team and we put them in the simulator, we've got historic data too. We can see how drivers throughout history would have raced in those conditions.
As for esports, Eckhouse explains:
What we do is analyze the laps done in the simulator rig, but from a gaming perspective, and use those insights to inform our race strategy. Just like the Formula One team analyzes their real-life laps and the data points that come through the track, using those insights to develop their race strategy in the real world.
It's a similar approach, but in esports ours is fully focused on the rigs. Yet the blurring of the physical and the virtual is one of the nuances of Formula One and F1 Esports, in that the game is incredibly similar to the real-life racing experience.
In both areas, Splunk has been integral to our overall practice regimen. The real-time data dashboards they've created for us from an F1 Esports perspective, quite genuinely led to us winning the championship last year and helped our driver Lucas Blakely win the individual F1 Esports Series Pro Championship.
Virtual crossover
So, do people ever cross from the virtual world into the real one? In other words, could McLaren identify esports talent and train them up to be real F1 drivers? Eckhouse says:
That's a hypothesis we would love to test more, and understand if that's a reality we can make happen. But Lucas is a brilliant real-life driver too, and has beaten Sebastian Vettel on a real-life track.
In both realms, analyzing data is critical for success, concludes Splunk's Hodge:
It's about good stats and predictive modelling. And we're starting to look at more areas for improvement. So, as we're improving lap times, what do we think is the ultimate place we could get to? Where is the best lap possible – looking at different tires and aerodynamic setups versus others? How long is this tire going to last in these conditions?
That's the kind of the area we're getting into now, plus what is the best type of practice to get ready for a Grand Prix? On race weekend, the McLaren team have done all of their 'What if?' planning, so they are, as much as possible, best prepared or resilient.
But of course, there are key differences between the real and virtual worlds, he says:
There's a lot more complexity in the physical one, because physics and practicalities are more in play. There are race locations all around the world. Every race weekend, McLaren moves in an IT rig that always follows the cars. It goes in the same plane and takes the telemetry that gets streamed off them from the track.
It also gets streamed over the Internet back to the McLaren Technology Centre. So, the first thing we do for them is make sure that's working perfectly, because it's mission critical: you're not allowed to start up a Formula One engine or keep it running without that telemetry, largely because of safety concerns.
They have 32 race engineers, over a weekend, sat in a calm environment making decisions that get relayed back to the trackside. So, they're running blind without that data. Plus, the secondary benefit is financial. These engines are very expensive, and you only have a few per season.
But he adds:
"The esports team gives us a lot more freedom to rapid prototype and put things into rapid development, whereas with the Formula One team there's so much more complexity, there's cost cap considerations. There's a lot more deliberate intent, if you like.
A great example is supercomputing capacity. You are limited per season in how much you can do. If you run, say, a computation for an hour, and it didn't write the results to the database because you've run out of disk space, then you've lost an hour you can never get back. So, our foundation is resilience.
For us, it's about the marginal gains that we can focus on to build that resilience for McLaren, to get better decision-making and mission-criticality. That's where digital systems are so important. And when you get that right, you can move on to the next thing, and the next, and start to foster a data culture.
Before, it was 'We just need to get great drivers and make them practice.' But now, it's 'How do we use data to make a more efficient decision on how to train better – on how to do things better?'
Welcome to the new world of racing: fast, accurate data means faster, better, safer cars: bit by achievable bit.


Lovers + Friends is for the girl who is a go-getter. She is in the know and on the scene, an early morning riser and late night explorer. Whether her flawless blazer look to the office or a floral dress while digging her toes in the sand, she always exudes confidence, grace with a side of sexuality.


This entire project, I have been unsure what to do about bulk. I mean the bulk that happens when a fluffy interlining gets sewn into seam allowances.
For the final shacket, I still plan to attach the interlining to the lining piece, and treat them as one. To deal with bulk in the seam allowances, I tried out a technique I found in Kenneth D. King's book, Cool Tricks.
You get a piece of "thin cheap" fabric, and cut it to the same shape as the bulky interfacing/interlining. Next, attach the two pieces with a zigzag stitch, using a wider seam allowance than you will use for the seams. (In the book, King uses a 1 inch seam allowance). Then, cut out the "thin cheap" fabric in the interior of the piece, up to the seam allowance. Then, trim the interfacing out of the seam allowance, and baste the "thin cheap" fabric to the fashion fabric. Finally, sew your construction seam. The "thin cheap" fabric is caught in the construction seam, but not the thicker interlining.
I made a sample using some organza as "thin cheap", some scrap sweatshirt fleece as the interlining, and flannel for the public-facing fabric. (At the time I made the sample, I was toying with the idea of attaching the interlining to the outer flannel, an idea I've since discarded).
This seemed to work pretty well, so for the actual shacket I plan to attach interlining to the lining piece with this method.
For the interlining, I started with some JoAnn's fleece, then stumbled upon some technical outerwear fabric that is both thinner and water-resistant. I thought it was a good idea.
Tammy, the studio owner at Sips N Sews, took one look at my technical outerwear fabric and immediately tried to talk me out of using it. First, it is better used for a garment all by itself – for instance, a pair of ski pants. Second, the water-resistant aspect won't work well. Since the outer shell of the shacket would be cotton flannel, it would absorb the water and then transport it to the seams, where it would leak to the inside.
Instead, she suggested the perfect alternative: a cut of poly-cotton (70/30) sweater knit fabric that had been sitting in the studio free-fabric bin waiting for the right project. It's just fluffy enough to provide the right amount of insulation, and the fact it is a knit means it will afford movement sandwiched between lining and the outer shell. It's kind of ugly, but it doesn't matter since it will be fully enclosed and not visible in the finished garment.
I'm really thrilled about this fabric, and I think it will work well.
It's finally time to talk about cuffs.
I want a shirt-style cuff, and I liked the cuff with the extension tab I saw in the store, so I'm making mine like that too.
The challenge has been how to make a lined garment with cuffs. It seems simple enough to make the outer sleeve and the lining the same length, and then to sew the outer sleeve plus lining as one unit into the cuff, so they both get caught by the cuff seam.
But a shirt-style cuff also has a slit running up the back, that is finished with a placket. How do I do that with a lining?
One option came from the sample photos I took at the store. An extra seam is added to the sleeve. That sleeve is flat-felled from the shoulder up to the end of the cuff opening. There, the lining seam allowance is stitched to the outer fabric from the inside. Turn it all right-side out, and the cuff opening is finished with the lining. A bar tack at the cuff opening anchors everything.
I tried making a quick sample, again to convince myself the construction steps would work. They did.
But another option presented itself on another espionage run to the mall. I spotted a different shirt jacket with a lining, cuffs, and a fairly standard placket to finish the opening.
I haven't made a sample yet, but likely will make one before final construction just to be sure there aren't any "gotchas" with an interlining and lining involved. I plan to use some form of continuous lap placket, rather than the traditional "tower" placket seen in a fine dress shirt.
I have completely eliminated the lower pockets from the design. I agree with MainelyDad's comments; the lower pockets read blazer or sportcoat rather than shirt. So I am going with chest pockets.
I'm using a contrast flannel as an accent fabric for the pockets. I don't have enough of the blue plaid flannel to go around, so I'm using the purple accent fabric for facings, inside cuffs, the undercollar and probably the sleeve plackets.
I did a bakeoff of pocket treatments, and settled on a bias cut for the pocket because it had the most visual interest. The pocket has a matching flap.
And in agreement with some critique I received at the studio, I am making one chest pocket rather than two. With the accent fabric, two pockets would be a little ostentatious.
Currently, I've cut all of the fabric pieces, and I'm ready to start constructing the outer and lining shells. More progress to report soon.
I have enrolled in a class in Fashion Draping at City College of San Francisco for the spring semester. Draping is the technique for creating sewing patterns from scratch, by molding and shaping fabric to a form, or to a live model.
The course covers much of the same material as a class I took with Paul Gallo at Sips N Sews a year ago. But since this is a full semester course, there is much more time and much more material to cover.
My instructor is Judy Jackson. She works professsionally in theater costuming, and she is also a Craftsy class instructor. I have previously viewed her Craftsy class Patternmaking for Knits: Essential Slopers and I like her teaching style.
I've been to two class sessions so far. We've covered draping a basic bodice sloper, both front and back, on a dress form. This coming week, we will drape a skirt sloper. Each class begins with a demonstration and lecture, followed by a lunch break and then a lab session where we carry out the same work on dress forms in the classroom.
Here's a photo of the drape I did in class, for the back of my bodice sloper.
The first day, we each chose a dress form we will work with for the remainder of the semester. Mine is a size 8 Wolf form, which is very similar to the form I have at home. While I won't be using my home form for the class assignments, I can use it for practice outside of class.
The classroom is also equipped with industrial sewing machines and irons. I got my first experience using an industrial iron, and while I'm not yet ready to ditch my domestic Black and Decker, I can say they are quite nice to use!
More on the class in future articles.


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Eric Perkins
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Never truly good enough to play college or professional sports, Eric Perkins decided to talk about them instead. Perk as he's better known, grew up immersed in sports, but also in television. His father Jack was an NBC Nightly News correspondent for decades before becoming the host of Biography on A&E. Perk combined his two passions and became a sportscaster where he worked in Tupelo, Memphis and Atlanta before finding his way to Minnesota where he currently serves as the sports director for the NBC station (KARE-TV) in the Twin Cities.
Since joining KARE in the late 90's, Perk has won several Emmy Awards for TV work. He's covered Super Bowls, Final Fours, All Star Games and even five Olympic Games. But he's perhaps best known for his Perk at Play segment, in which he's taken part in everything from Skydiving to Demolition Derby, playing tennis with John McEnroe and being body slammed by Brock Lesnar during the decade long run of the segment.
Perk is very involved with local charities and often can be found serving as an emcee for galas, fundraisers, or awards ceremonies throughout the state. Over the last few years, Perk has emceed events for Gillette Children's Hospitals, Children's Cancer Research Fund, Second Harvest Heartland, Spare Key Foundation, St. Jude and many others. He even created his own charity event, Perk's MessFest. The "slopstacle course" for kids is now in its fifth year, and benefits the Pinky Swear Foundation which helps families dealing with childhood cancer. Perk also regularly emcees that Foundation's annual gala as well.
Perk lives in the western suburbs of the Twin Cities with his wife, three children and cockapoo.
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Our Sales jobs in Cleveland offers exceptional opportunities for advancement and experience. It is not unusual for our people to be entrusted to take on challenging projects early in their careers. We are committed to helping our employees develop their skill-sets through training programs and through interaction with top talent.
At Chart Industries you will have the satisfaction of working for a company that is committed to doing the right thing not only in business but for our employees, the communities where we operate, and the environment.
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Farmer shot dead by Indian soldier from across LoC
Tariq NaqashNovember 16, 2019
MUZAFFARABAD: A young tractor driver lost his life in Azad Jammu and Kashmir (AJK) on Friday after an Indian soldier shot him from across the restive Line of Control (LoC) in what officials say was an incident of targeted killing.
Mohammad Ali, son of Ghulam Hussain, was ploughing a field in Nali village — just a stone's throw from the unmarked dividing line in tehsil Barnala — when a single bullet struck him in the neck, said Ansar Mahmood, a police official based in the area.
"The 20 years old fell from the tractor and died on the spot," he added.
The deceased, an orphan who eked out a living by driving someone's tractor, was laid to rest in the evening in Bandala village instead of his native Seri village due to its vulnerability to Indian shelling.
According to officials, while doing different chores without any presentiment of danger, people living in the closest proximity of the LoC often end up falling victims to targeted firing by trigger-happy Indian troops.
"It is a brutal act of targeted killing, something for which Indian troops stationed at the LoC had gained notoriety over the years," said Chaudhry Tariq Farooq, the AJK's senior minister, who also belongs to Bhimber district.
"He is the latest victim of the cowardly and dreadful Indian practice of purposely targeting unarmed and innocent civilians in AJK with high calibre weapons even when the ceasefire line is apparently calm," he added.
Prime Minister Raja Farooq Haider also took to Twitter to condemn the latest incident of targeted killing along the ceasefire line (LoC).
"...Skirmishes and artillery duels between rival troops are not something uncustomary in a conflict zone but hitting non-combatant civilians in such a fashion is typical of the coward Indian army. Shame on them," he wrote.
According to Syed Shahid Mohyiddin Qadri, the secretary of the AJK government's disaster management authority, the LoC was regularly witnessing ceasefire violations by the Indian army, notwithstanding the November 2003 truce, and as a result civilian casualties were also regularly occurring.
In the ongoing year, as many as 56 civilians have lost their lives and another 266 sustained injuries in different parts of AJK due to firing by Indian troops, he said.
Published in Dawn, November 16th, 2019
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