text:
Excerpts from Airway Physiology and Anatomy: A Deep Dive Chapter in Airway Management in Emergencies the Infinity Edition
Airway Anatomy: Its Importance
A clear mental picture or "gestalt" of upper airway anatomy is an essential cognitive underpinning to emergency airway management skills. For those patients presenting in extremis or with a decreased level of consciousness it may not be possible for the clinician to perform a complete airway examination. However, much can be gleaned by a systematic visual inspection of the patient that may help the clinician in managing the airway:
A. Making decisions. Assessment of a patient's airway anatomy is the foundation upon which the airway plan is built. If induced and paralyzed, can the patient be ventilated with bag-mask ventilation (BMV)? Intubated by direct- or hyperangulated blade videolaryngoscopy? If difficulty is encountered, can rescue oxygenation occur via an extraglottic device or cricothyrotomy? Based on this assessment, the clinician can decide how to proceed: with a rapid-sequence intubation (RSI), an awake intubation, or primary surgical airway.
B. Structure and function. Knowledge of airway anatomy and its dynamic changes facilitates the appropriate performance of airway opening skills and BMV. These skills depend on an understanding of functional airway anatomy: how the tissues behave with the patient in either the awake or obtunded state.
C. Landmark recognition. A sound three-dimensional appreciation of the laryngeal inlet and its surroundings is critical for optimal laryngoscopy. Anatomic structures adjacent to the glottic opening, such as the epiglottis and paired posterior cartilages help provide a "roadmap" to the cords. The anatomic or pathologic variations in airway anatomy depending on pathology must be understood and anticipated (i.e. the ability to go 'off road' and still be oriented).
D. Spatial orientation. Particularly when using blind or indirect visual tracheal intubation techniques, a clear mental image of the anatomy through which the instrument is traveling is required. Problem solving through intubation with a video laryngoscope or through an intubating laryngeal mask airway is much easier with a solid appreciation of potential anatomical barriers.
The Laryngeal Inlet
The clinician should be very familiar with the component parts of the laryngeal inlet that are visually presented at laryngoscopy (Video 1).
Video 1: Dynamic laryngoscopy anatomy.
The paired vocal cords are the "target" for the laryngoscopist and are identified by their whitish color and triangular orientation. Surrounding the vocal cords, the laryngeal inlet is bordered anteriorly by the epiglottis, laterally by the aryepiglottic folds, and posteriorly by the cuneiform and corniculate tubercles (posterior cartilages), and the interarytenoid notch (Fig. 7).
Figure 7: Laryngeal (glottic) inlet anatomy
The epiglottis projects upward and backward, behind the hyoid bone and base of tongue, and overhangs the laryngeal inlet.[22] The superior surface of the epiglottis is attached to the hyoid bone by the hyoepiglottic ligament (Fig. 3), while the inferior surface attaches to the thyroid cartilage via the thyroepiglottic ligament. The overlying mucosa on the upper surface of the epiglottis sweeps forward to join the base of the tongue, with prominences forming the median and paired lateral glossoepiglottic folds. The paired valleys between these folds are called the vallecullae, although both vallecullae are commonly referred to together as the vallecula (Fig. 3 & Fig. 5, Video 2).
Video 2: More dynamic laryngoscopy anatomy.
The epiglottis should be actively sought by the laryngoscopist (epiglottoscopy) as a guide to the underlying glottic opening.[23] To expose the vocal cords, the tip of a curved (e.g., Macintosh) laryngoscope blade can be advanced into the vallecula until it engages the underlying hyoepiglottic ligament ('valleculoscopy') (Video 2 & Video 3).
Video 3: Sagital section dynamic laryngoscopy.
Forward, distal pressure on the hyoepiglottic ligament with the blade tip "flips up" the epiglottis anterior, towards the base of the tongue allowing for a line-of-sight view into the larynx (laryngoscopy). Although the hyoepiglottic ligament itself is not necessarily visualized, one can often see the midline glossoepiglttic fold (Video 2). The hyoepiglottic ligament 'lives' underneath this fold. With correct placement of the blade tip, the glossoepiglottic fold should not be visualized. This precise placement of the blade tip into the base of the vallecula that results in engagement of the ligament is a likely explanation of why a skilled laryngoscopist may achieve a much-improved view (with less force) on a patient after a less experienced clinician has struggled. Attempts to lift the tongue prematurely, before the hyoepiglottic ligament is engaged at the base of the vallecula, will often result in an inadequate view of the glottic inlet (Video 2 & Video 3). Clinicians preferring straight blade direct laryngoscopy usually elect to place the blade beneath the epiglottis and directly lift it. Either way, the epiglottis is an important landmark in airway management and should be a source of reassurance, not anxiety.
Originating laterally from each side of the epiglottis toward its base, the aryepiglottic folds form the lateral aspect of the laryngeal inlet by sweeping posteriorly to incorporate the cuneiform and corniculate cartilages. The corniculate cartilages overlie the corresponding arytenoid cartilages, and appear as the characteristic "bumps" (tubercles) posterior to the vocal cords. In practice, many clinicians refer to these prominences as the arytenoids. Confusion can be avoided by referring to the tubercles collectively simply as the "posterior cartilages" (Fig. 6) The underlying arytenoids are anatomic hinges used by laryngeal muscles to open and close the vocal cords. Between and slightly inferior to the paired posterior cartilages lies the interarytenoid notch (Fig. 7, Video 1). With the cords in the abducted position, this notch widens to a ledge of mucosa stretching between the posterior cartilages, but with the cords in a more adducted position, the interarytenoid notch narrows simply to a small vertical line. The interarytenoid notch is important during laryngoscopy because, in a restricted view situation, it may be the only landmark identifying the entrance to the more anteriorly located glottic opening.[23]
Posterior to the laryngeal inlet lies the esophagus. It should be noted that the entrance to the upper esophagus is not held open by any rigid structures, and at laryngoscopy is often not seen at all. Conversely, when the esophageal entrance is seen, it can look like a dark (and sometimes inviting) opening (Fig. 8). With enough pressure exerted, the sidewalls of the esophagus can appear pale, imitating the appearance of the vocal cords. This so-called 'glottic impersonation' is particularly true in the neonate.[24] This highlights the importance to the laryngoscopist of knowing the expected landmarks of the laryngeal inlet: the posterior cartilages, aryepiglottic folds and overlying epiglottis surround the glottic opening, and not the esophagus!
Figure 8: The esophagus can look remarkably like a glottic inlet if one is just looks for a patent hole. Identifying the surrounding structures of the glottic inlet is critically important during laryngoscopy.


With almost P5 billion in collection since the start of the year, the figure could well be the city's biggest revenue collection  in the City Treasure's Office's (CTO) history.
Technology experts, entrepreneurs, and enthusiasts will come together for the launch of Geeks Unplugged on July 14 at Costa Marina, Samal.
In addition to indorsing a more active food and beverage exchange between Philippines and Indonesia, organizers of the 2nd Indonesia Expo said they will also promote direct trading of goods to revitalize the Davao-General Santos-Bitung trade route launched last year.
The 6th Watershed Stakeholders Summit on June 28, 2018 at the Grand Men Seng Hotel will forge the collaboration between the Province of Bukidnon and City of Davao in protecting and managing the Davao River Basin, as one of the 17 major river basins in the country.
Despite the ongoing implementation of the closed fishing season along the Davao Gulf, global warming, and climate change could potentially decrease the production of the fishing industry in the region.
Indigenous People (IP) leaders from three major Mindanao IP networks convened to launch Lumad Husay Mindanaw (LHM), an intertribal solidarity designed to promote IP inclusion in the ongoing peace process between the Philippine government and the National Democratic Front of the Philippines (NDFP).
After a day's worth of observing the dry-run of the one-way traffic scheme for the proposed widening of Talomo Bridge 2, the City Transport and Traffic Management Office (CTTMO) has decided to put on hold the project until all other road development in the area are completed.
Marking its 50th founding anniversary, the Davao City Chamber of Commerce and Industry, Inc. (DCCCII) will stage the largest and longest running trade expo in Southern Philippines this coming September 20-22, 2018.
The City Council has ordered public and private agencies involved in the management of the Maa Slaughterhouse to take immediate action and respond to the complaint that the operation has been causing inconvenience among the residents in the area.


text:
Militant Coal Miners Occupy Kentucky Railroad Over Unpaid Wages
On Monday afternoon, workers in Pikesville, Kentucky halted a 120-car train carrying their employer's coal. Some workers say they're owed $3,000.
by Lauren Kaori Gurley
Photo by Scott Olson/Getty Images
Kentucky coal miners are protesting unpaid wages by occupying railroad tracks for the second time in the past year.
On Monday, Quest Energy workers heard that their employer planned to haul coal from one of its mines in Eastern Kentucky, and quickly organized to block and stop the 120-car freight train.
Roughly 12 workers and their families gathered around a campfire by the tracks on Monday night, and told a reporter at the Lexington Herald Leader that they would not leave until the company gives them 3 weeks of unpaid wages.
Miners say that roughly 50 workers are owed between $2,000 and $3,000 each—and haven't been paid since December 27—despite working daily, sometimes on 17-hour shifts, according to the Herald Leader.
"If they had paid us on our pay days, we wouldn't be here blocking the train," one of the coal miners, Kenny Collins, told local reporters on Monday night. "But as far as we're concerned, that coal belongs to us. We mined it out, and they didn't pay for it."
Some miners told local reporters that they were behind on rent, while others had their electricity turned off and could not afford their children's extracurricular activities.
"Our power was cut off this morning and they said if it was paid within the hour, they wouldn't shut it off, and our mother-in-law helped us pay it," said Collins. "I should have been paying [for the power] because I worked every day."
Quest Energy, a subsidiary of the coal giant American Resources Corporation, did not respond to Motherboard's request for comment, but said in a statement provided to the Herald Leader that it owes some miners for eight days of work and others for one day, and that none of them worked 17-hour shifts.
In October, the coal company Blackjewel agreed to pay 1,100 coal miners $5.1 million in back wages, after they blocked a coal train in Harlan County, Kentucky, for two months in protest of unpaid wages. That protest drew national attention and support from labor activists and politicians, including senators Bernie Sanders and Mitch McConnell.
The train blockades arrive during a wave of labor strikes that has spread across the country, which some experts argue originated out of the former union strongholds of Appalachia. In 2018, roughly half a million workers walked off the job—more than in any year since 1986, and up from 25,000 in 2017. Experts expect that the number of workers engaging in strike activity was similar last year.
This article originally appeared on VICE US.

redpajama_set_name: RedPajamaCommonCrawl


The aim of the journal is to advance the evidence base in infection prevention and control, and to provide a publishing platform for all health professionals interested in this field of practice. Journal of Infection Prevention welcomes papers that address aspects of infection prevention and control and contribute to development and understanding of relevant theory or practice.
Primary care professionals including general practice staff, dental staff and sexual health specialists.


Earlier this week, Penguin announced that its social networking site for writers has added a self-publishing feature, but not everyone is recommending it.
Best selling self-published author J.A. Konrath has written a blog post warning new writers who are considering self-publishing to consider other routes. In the post, he warns writers about Book Country's fees for formatting eBooks and the cost for uploading these eBooks to retail stores.
In the post he advises young writers of less expensive or flat out free ways to get your eBook formatted and submitted to eBook retailers. Konrath punctuates his point with dollars and cents. He goes on: "These people charge a flat fee and you keep all of your rights. Which means that when you upload to Amazon.com and sell an ebook for $2.99, you keep $2.05, not the $1.47 Book Country gives you. And trust me. That adds up.


text:
Miguel Maravilla
Paquiao Vows to KO Broner
HOLLYWOOD, CALIF. (January 2, 2019) – Senator Manny "Pacman" Pacquiao (60-7-2, 39 KOs), boxer laureate and the sweet science's only eight-division world champion, has a goal. That goal is to knock out his next opponent, Cincinnati's Adrien "The Problem" Broner (33-3-1, 24 KOs), when they collide on Saturday, January 19, at the MGM Grand Garden Arena in Las Vegas, Nevada. Presented by Premier Boxing Champions, the Pacquiao vs. Broner WBA welterweight world championship event will be produced and distributed live by SHOWTIME PPV® beginning at 9 p.m. ET / 6 p.m. PT.
"I am not making a prediction but my goal is to knock out Broner," said Manny on Monday as he was wrapping his hands before starting a rigorous workout, which included 12 rounds of hitting the mitts with world-famous Freddie Roach, at Roach's Wild Card Boxing Club.
"I am looking for a knockout against Broner. I have to maximize the opportunity. I forgot how much fun winning a fight by knockout was until I stopped Lucas Matthyssee last summer to win the WBA welterweight title. It felt great to win that way and the fans loved it too, so why not try for it again? I have nothing personal against Adrien Broner. This fight is strictly business. He is fun. He makes me laugh. He knows how to sell himself and to sell a fight."
It's been strictly business tor Manny at Wild Card since beginning his U.S. training camp on Christmas Eve. No shutdowns or holidays have kept him away. After celebrating New Year's Eve with a five-mile run up the hills to the Hollywood sign and 12-rounds of mitt work with Roach, Manny began 2019 the same way he ended 2018, only this time he sparred 12 rounds with three younger sparring partners in addition to a full session of bag work capped off with 1,000 situps.
"He runs like a deer," said Justin Fortune, who oversees Manny's strength and conditioning. "No one can keep up with him. That's the secret to his success -- his work ethic and his stamina. He has the strongest foundation of any fighter with whom I've worked. His legs and calves still generate more power and speed than younger fighters."
"I am very pleased with the training camp Manny has had. His footwork, distance and angles are all coming together nicely," said trainer Buboy Fernandez. "When he hits the mitts it sounds like an explosion. I have never felt such raw power."
"I think experience has made Manny a better fighter," added Roach. "He still trains harder than anyone. I like Broner as a fighter. I think he has excellent boxing skills. But Broner has never faced anyone like Manny. Broner will be mentally exhausted within four rounds and physically spent within six. It will be impossible for Broner to keep pace with the Manny Pacquiao of this training camp."


text:
Q: Error with npm update: pngquant binary does not seem to work correctly I am getting the following error with my npm update command:
> pngquant-bin@4.0.0 postinstall /var/www/pp/20180315202846/node_modules/pngquant-bin
> node lib/install.js

  ⚠ The `/var/www/pp/20180315202846/node_modules/pngquant-bin/vendor/pngquant` binary doesn't seem to work correctly
  ⚠ pngquant pre-build test failed
  ℹ compiling from source
  ✔ pngquant pre-build test passed successfully
  ✖ RequestError: pngquant failed to build, make sure that libpng-dev is installed
    at ClientRequest.req.once.err (/var/www/pp/20180315202846/node_modules/pngquant-bin/node_modules/got/index.js:111:21)
    at Object.onceWrapper (events.js:272:13)
    at ClientRequest.emit (events.js:180:13)
    at ClientRequest.onConnect (/var/www/pp/20180315202846/node_modules/pngquant-bin/node_modules/tunnel-agent/index.js:168:23)
    at Object.onceWrapper (events.js:272:13)
    at ClientRequest.emit (events.js:180:13)
    at Socket.socketOnData (_http_client.js:476:11)
    at Socket.emit (events.js:180:13)
    at addChunk (_stream_readable.js:269:12)
    at readableAddChunk (_stream_readable.js:256:11)
npm WARN optional SKIPPING OPTIONAL DEPENDENCY: fsevents@1.1.3 (node_modules/fsevents):
npm WARN notsup SKIPPING OPTIONAL DEPENDENCY: Unsupported platform for fsevents@1.1.3: wanted {"os":"darwin","arch":"any"} (current: {"os":"linux","arch":"x64"})

npm ERR! code ELIFECYCLE
npm ERR! errno 1
npm ERR! pngquant-bin@4.0.0 postinstall: `node lib/install.js`
npm ERR! Exit status 1
npm ERR!
npm ERR! Failed at the pngquant-bin@4.0.0 postinstall script.
npm ERR! This is probably not a problem with npm. There is likely additional logging output above.

I already did:
 apt-get install libpng-dev

but I still get this error.
Any ideas? (My distribution is Debian 9.2)

A: For Ubuntu you need to run:
wget -q -O /tmp/libpng12.deb http://mirrors.kernel.org/ubuntu/pool/main/libp/libpng/libpng12-0_1.2.54-1ubuntu1_amd64.deb \
  && sudo dpkg -i /tmp/libpng12.deb \
  && rm /tmp/libpng12.deb

A: TLDR;
use node:latest instead of node:alpine for docker image
—
Hi, I was using docker image node:alpine and it crashes yesterday too. Seems to be a problem with some external package that laravel-mix requires. I tested on node:alpine node:8.10.0-alpine node:8.8.1-alpine nothing works. I tested laravel-mix 0.11.4 and 0.12.1 and 1.0 nothing works. But when I switch from node:alpine to node:latest, it works. Hope this helps

A: Perhaps you will finds some help here at the original issue.
https://github.com/imagemin/pngquant-bin/issues/78
He is a suggested fix: (copy/paste from: https://github.com/imagemin/pngquant-bin/issues/78#issuecomment-374192838)
As @velu76 and @sory19 said, I followed their method:
´sudo apt-get install libpng-dev´
´npm install -g pngquant-bin´
Since I had already 'npm install' in my repo/project folder, I then ran
´sudo rm -rf node_modules´
then, still in my repository/project folder
´npm install --no-bin-links´
And it works right now.
I don't know if it's just a temporary fix, actually, but I can work for now.

A: You can fix this error by executing this command :
sudo npm install -g name-of-package --unsafe-perm=true --allow-root

A: I was also facing same issue and tried all provided solutions but nothing works
Issue on windows 10, Node 16, npm 8
but by downgrading my node to 14 and npm to 6 solve my problem.

redpajama_set_name: RedPajamaStackExchange


When Wiggle approached us, they wanted their paid display advertising to work harder during key sales periods throughout the year. The first being Spring. It's a competitive time of year with their customers starting to get out on their bikes again, so Wiggle needed something that was going to stand out.
Focused on the UK, US, France, Germany, Spain and Italy, this global rollout needed to use drivers other than just straightforward discounts.
We decided to create contextually relevant, weather-dependent advertising. We linked Google AdWords to a weather.com API to allow the platform to know where the users were based, check the weather for the coming days and then serve adverts that either focused on sunny days or rainy days. The result was a more relevant advert with a suitable product.
We kept the adverts and website skins interesting and visually engaging through HTML5 animation and alsoensured that the products (road or triathlon) were promoted dynamically within each advert set and matched where the adverts we displayed.


← ITU and UNESCO Chair in ICT4D session at WSIS Forum 2018: International decision-making in ICT – where are the women?
I have long struggled with understanding why Labour under Corbyn has not been more forthright in supporting the Remain campaign. To be sure, such ambivalence must in part be because of the diversity of views within Labour's membership, but they risk losing many of their younger supporters once the harsh economic, social, political and cultural realities of leaving the EU hit home.
The sacking of Owen Thomas from the shadow cabinet for his principled stand in favour of a second referendum, and for highlighting the risks of Brexit, emphasises the deep divisions within Labour and the power that the leader holds.
Because he wants to be seen as the leader who made Britain great again.
However, his logic, if indeed that is what it can be called, is deeply problematic.
In 2016 he asserted that he wanted "a Europe that is based on social justice and good, rather than solely on free-market economics".
To be sure, some people can grow wiser with age and change their minds. After winning the election in 2017 he said clearly that he wanted the UK to remain a member of the EU, but most of his recent actions would run counter to this assertion. Most importantly, he has done very little to put this aspiration into practice, and seeks to penalize any of his MPs who support a second referendum and express a desire to remain within the EU.
Corbyn's criticisms of the EU fail to acknowledge the very considerable support that it has given to workers' rights and social welfare across Europe. Workers in Britain have benefited considerably from this, and it is unlikely that they would have done so had the UK not been part of the EU over the last 45 years.
He will then be seen as the glorious saviour of a Britain that will indeed be made great again as a result of his actions.
For this to succeed, he cannot in any way be seen as supporting any of the present government's policies towards the EU, he must continue to advocate that the EU serves the interests of the owners of capital rather than the workers, and he must encourage the collapse of our economy and society so that his policies can be seen as restoring our (and his) greatness again.
It seems so sad that on these critical issues he has failed to see the very considerable benefits that being part of the EU gives to Britain. Instead of simply leaving the EU, we should remain at its heart and change it from within. Outside the EU, Britain has little voice, little power, and none of the benefits that belonging to it can bring to all of our citizens.
I follow your blogs from time to time, ever since corresponding with you about hip replacement experiences. Some interesting pieces written Hope your are fit & well !
Your latest piece states your EU position & opinions at the very outset & end very clearly.
"but they risk losing many of their younger supporters once the harsh economic, social, political and cultural realities of leaving the EU hit home".
Is that a Labour, Corbyn or Tim Unwin Brexit sentiment ?
Outside the EU, Britain has little voice, little power, and none of the benefits that belonging to it can bring to all of our citizens".
I actually agree with you on Corbyn for the most part, but not the glass fully empty EU comments. Surely the last two weeks (Russia) shows that although we are leaving we are still going to be strong allies in everything related to practical common sense, a list too long to mention ?
To tell you the truth, I am far more concerned over the prospect of a Corbyn led government, than I am over Brexit. He would plunge us back to the darker days in Britains history.
I run my own company, currently in its 36th year and the prospect of 2/3 years down the road after exiting the EU excites me greatly however.
It is my view that Labour will risk losing their younger supporters.
I do also feel very strongly that Britain outside the EU will not have the wider strength and influence that it would have if it remained n the EU – but let's see.
I do hope you are right, but am not as optimistic.


The NAACP Louisiana State Conference will host a swearing-in ceremony to install its newly-elected officers.
Former Baton Rouge NAACP President Mike McClanahan has been sworn in as the new NAACP State President along with other executive officers. Southern University Law Center Chancellor John Pierre served as the guest speaker and Judge Don Johnson presided. Other elected officials from throughout the city and state were also in attendance.
"We're excited to start this new chapter and continue the legacy and the mission of the NAACP," McClanahan said. The event was held on Saturday, Jan. 6 at the Louisiana State Archives, 3351 Essen Lane, in Baton Rouge at 1 p.m.


My wife and I recently watched a documentary film called Queen of the Sun: What are the bees telling us? This film is so inspiring and informative and I believe everyone should sit down and watch it… tonight. Here is my personal review of Queen of the Sun.
I will start my review by saying: "Watch this film." Even if you don't read this entire article, jot down the name of the movie and go watch it. Even if you're not a beekeeper, go watch this film. Even if you have never heard about Colony Collapse Disorder, Varroa mites or other ailments affecting bees across the globe, go watch this film. You will not regret it.
Queen of the Sun is an extremely powerful documentary that highlights the importance of bees for pollination throughout the world as well as the potential factors that are leading to the disappearance of these same bees.
This film doesn't focus too much on any single factor that may be contributing to colony collapse disorder but rather presents the viewer with an array of ways that humans have interfered with these wonderful creatures that we rely on for producing 1/3 of all the food that we eat.
Throughout the film, there are also some great interviews with beekeepers from around the world. It's amazing to see beekeepers from England, Australia, France, Italy and the United States all providing their insight into a global epidemic. It's also very interesting to see the different types of beehives that each one uses. (Check out the special features on the DVD for more information on each hive type).
Grow flowers, plants and herbs to help provide food for bees.
Eliminate pesticides in your garden and lawn.
Bees are thirsty. Provide a continuous shallow basin with clean water in your garden.
Buy directly from a local beekeeper who avoids chemicals and produces raw honey.
Eat organic and pesticide free food.
Become a beekeeper with sustainable practices.
This documentary did not necessarily change my overall views on beekeeping, but it served to open my eyes a bit wider on the subject. I suddenly found that I have become a bit more passionate about bees when talking to others, and I tend to bring up this film frequently when involved in beekeeping conversations. This is a film that I believe everyone should watch.
Here's the trailer for Queen of the Sun: What are the bees telling us?


I just wanted to let you know I enjoyed meeting you. You are a very interesting person! Thanks for allowing me to feel comfortable in a group of people perhaps much more advanced in their writing than I am. I had a lot of fun. Wish I were going to be in the last class. I hope you offer another class in the future. I will do my best to attend!


text:
package hudson.util;

import java.util.Arrays;
import java.util.HashMap;
import java.util.HashSet;
import java.util.Locale;
import java.util.Map;
import java.util.Set;
import java.util.Stack;
import org.apache.commons.jelly.XMLOutput;
import org.xml.sax.Attributes;
import org.xml.sax.ContentHandler;
import org.xml.sax.SAXException;
import org.xml.sax.XMLFilter;
import org.xml.sax.helpers.XMLFilterImpl;

/**
 * {@link XMLFilter} that checks the proper nesting of table related tags.
 *
 *

 * Browser often "fixes" HTML by moving tables into the right place,
 * so failure to generate proper tables can result in a hard-to-track bugs.
 *
 *

 * TODO: where to apply this in stapler?
 * JellyClassTearOff creates XMLOutput. Perhaps we define a decorator?
 * We can also wrap Script. would that work better?
 *
 * @author Kohsuke Kawaguchi
 */
public class TableNestChecker extends XMLFilterImpl {

    private final Stack<Checker> elements = new Stack<>();
    private final Stack<String> tagNames = new Stack<>();

    public static void applyTo(XMLOutput xo) {
        xo.setContentHandler(new TableNestChecker(xo.getContentHandler()));
    }

    public TableNestChecker() {
        elements.push(ALL_ALLOWED);
    }

    public TableNestChecker(ContentHandler target) {
        this();
        setContentHandler(target);
    }

    @Override
    public void startElement(String uri, String localName, String qName, Attributes atts) throws SAXException {
        String tagName = localName.toUpperCase(Locale.ENGLISH);

        // make sure that this tag occurs in the proper context
        if(!elements.peek().isAllowed(tagName))
            throw new SAXException(tagName+" is not allowed inside "+tagNames.peek());

        Checker next = CHECKERS.get(tagName);
        if(next==null)  next = ALL_ALLOWED;
        elements.push(next);
        tagNames.push(tagName);

        super.startElement(uri, localName, qName, atts);
    }

    @Override
    public void endElement(String uri, String localName, String qName) throws SAXException {
        elements.pop();
        tagNames.pop();
        super.endElement(uri, localName, qName);
    }

    private interface Checker {
        boolean isAllowed(String childTag);
    }

    private static final Checker ALL_ALLOWED = new Checker() {
        @Override
        public boolean isAllowed(String childTag) {
            return true;
        }
    };

    private static final class InList implements Checker {
        private final Set<String> tags;

        private InList(String... tags) {
            this.tags = new HashSet<>(Arrays.asList(tags));
        }

        @Override
        public boolean isAllowed(String childTag) {
            return tags.contains(childTag);
        }
    }

    private static final Map<String,Checker> CHECKERS = new HashMap<String, Checker>();

    static {
        CHECKERS.put("TABLE",new InList("TR","THEAD","TBODY"));
        InList rows = new InList("TR");
        CHECKERS.put("THEAD",rows);
        CHECKERS.put("THEAD",rows);
        CHECKERS.put("TR",   new InList("TD","TH"));
    }
}

redpajama_set_name: RedPajamaGithub


A Call Super DJ set is quite something to behold. Well accustomed to commanding the dancefloor with house and techno eccentricities, Joe Seaton's sets under this alias are refreshingly unpredictable, as captured on his fabric 92 mix earlier this year. Yet where behind the decks flits effortlessly from four-to-the-floor to cuts like Sonique's It Feels So Good and everywhere in between, his output is of a far more distinguished and clear-cut palette.
His latest release Arpo is the second LP incarnation of his signature fluid, ambient, IDM-inflected productions. Like the lineage of painters which form his familial heritage, Arpo is the blank canvas upon which Seaton has crafted an ambitious and indeed accomplished array of texture, of depth, and of colour. As bizarrely visual as it is sonically sublime, it is that disorientating 6am walk home from a club on a frosty and calm winters morning, where strokes of orange begin to seep like ink into a dark skyline.
For the most part, we're in somewhat gentler territory on the A side before there's a noticeable descent at (the appropriately titled) Arpo Sunk. Though OK Werkmeister is an unmistakably rigid and somewhat claustrophobic few minutes of scribbling woodwind (played throughout the album by his Dixieland musician father), Korals is a daze of gentle knocks and hums punctuated by mellow richochets. Music Stand – perhaps the dreamiest, most harmonious track on the album – sweeps you away with keys, which shower down upon you midway in a drenching, euphoric rush.
Yet there's an edge to Arpo which, akin its predecessor Suzi Ecto, cuts through the gorgeous, comforting liquidity of his production. Here, the metallic scrapes on Out To Rust and the flitter of synths against a more foreboding abyss in Trokel hollow out that warm and wonderful weirdness of your post-club stroll home like twinges of anxiety. Elucidated in the title of lead single I Look Like I Look in a Tinfoil Mirror, off-kilter beats are matched with an equally off-kilter mind.
It's this very mixture of moments of lucidity and daze which make for such an absorbing experience. This abstract, ambient liminal space to which Arpo transports you is steeped in the idiosyncrasies of his sound, where rhythms and melodies are as smoothly and as subtly intertwined as they are deconstructed. It is a masterful release from an artist whose ascent continues to excite and inspire.


text:
from __future__ import unicode_literals

from django.db import models, migrations
import datetime

class Migration(migrations.Migration):

    dependencies = [
        ('electronics', '0010_auto_20141120_0704'),
    ]

    operations = [
        migrations.CreateModel(
            name='Order',
            fields=[
                ('id', models.AutoField(verbose_name='ID', serialize=False, auto_created=True, primary_key=True)),
                ('reference', models.CharField(max_length=500)),
                ('shipping_num', models.CharField(max_length=20, blank=True)),
                ('supplier', models.CharField(max_length=100, blank=True)),
                ('notes', models.TextField(default=b'', blank=True)),
                ('date', models.DateField(default=datetime.datetime.now)),
            ],
            options={
            },
            bases=(models.Model,),
        ),
        migrations.CreateModel(
            name='OrderComponent',
            fields=[
                ('id', models.AutoField(verbose_name='ID', serialize=False, auto_created=True, primary_key=True)),
                ('quantity', models.IntegerField(default=1)),
                ('price', models.IntegerField(blank=True)),
                ('component', models.ForeignKey(to='electronics.Component')),
                ('order', models.ForeignKey(to='electronics.Order')),
            ],
            options={
            },
            bases=(models.Model,),
        ),
        migrations.CreateModel(
            name='WishItem',
            fields=[
                ('id', models.AutoField(verbose_name='ID', serialize=False, auto_created=True, primary_key=True)),
                ('notes', models.TextField(default=b'', blank=True)),
                ('component', models.ForeignKey(to='electronics.Component')),
            ],
            options={
            },
            bases=(models.Model,),
        ),
        migrations.AddField(
            model_name='component',
            name='notes',
            field=models.TextField(default=b'', blank=True),
            preserve_default=True,
        ),
        migrations.AddField(
            model_name='componenttype',
            name='notes',
            field=models.TextField(default=b'', blank=True),
            preserve_default=True,
        ),
        migrations.AddField(
            model_name='parameter',
            name='notes',
            field=models.TextField(default=b'', blank=True),
            preserve_default=True,
        ),
        migrations.AddField(
            model_name='stock',
            name='notes',
            field=models.TextField(default=b'', blank=True),
            preserve_default=True,
        ),
    ]


ReSound has been actively involved with Help America Hear for some time now, as the sole provider of hearing aids to the program. We were recently asked to help award two scholarships by judging essays submitted by hearing impaired students. The winning students each received a $500 scholarship to be applied to the college of their choice, in addition to two state-of-the-art ReSound hearing aids.
Hearing impaired students were invited to submit essays about the experiences and challenges they face in all phases of life due to their hearing impairment. The two scholarships were awarded to the students that best exemplified the ideas of reaching their full potential, while dealing with the daily challenges of hearing loss.
Over the next week, we will be posting the winning essays on the ReSound blog.
This entry was posted in Charity, Company News and tagged Foundation for Sight and Sound, hearing aids, Help America Hear. Bookmark the permalink.


text:
VR and learning design: challenges and possibilities for teachers and students
by Brett Henebery 23 Feb 2022
Studies have shown that Virtual reality (VR) and Augmented Reality (AR) technologies can be used to improve the design of learning spaces, allowing students to learn without distraction, as well as simulate the classroom experience for pre-service teachers, who can test out their teaching skills to support learning, engaging their learners, and managing behaviours.
The Educause Horizon Report has been claiming that Extended Reality (XR) technologies, which incorporate Virtual Reality, Augmented Reality and Mixed Reality (MR), are going to become more and more prominent in schools for at least a decade.
"While widespread adoption is still some way off in most schools, XR technologies, especially in the form of mobile devices and head mounted display units are likely to become more common in schools, most probably in extra-curricular or elective settings, to begin with," Dr Keith Heggart, a Lecturer in Learning Design at the University of Technology Sydney, told The Educator.
"The pace of adoption will increase, as factors such as cost, and the availability of VR assets designed for education make it more accessible for all schools."
Dr Heggart said even for those educators that are early adopters, there are significant hurdles still to be overcome to effectively and efficiently integrate XR technologies within schools and classrooms.
"The most notable of these is the cost: while there are some low-cost options, such as Google Cardboard, most head mounted units are still expensive [at least $500] – especially if schools are buying class sets," he said.
"This can be navigated through AR approaches and using mobile devices, but these lack the important aspect of presence which is crucial to learning with XR."
Another consideration, said Dr Heggart, is the availability of assets, such as interactive environments.
"Not many teachers are likely to have the time to develop their own 3D learning assets, and this means that they must rely on other companies to produce environments and materials," he said.
"This industry is rapidly increasing in pace, and there are already some excellent open source resources available."
However, the biggest challenge facing educators wishing to make use of XR in their classroom lies in convincing leaders about the effectiveness of XR in terms of learning outcomes, said Dr Heggart.
"This area is still very much a live issue in educational research, although researchers like Associate Professor Erica Southgate are producing interesting insights about the use of VR in education."
Dr Heggart said XR, while at this early stage, offers some real opportunities for educators.
"Importantly, VR, according to some researchers, works more like a real-world experience, rather than a mediated experience," he said.
This means it's more like actually 'being there' than, for example, a film where you watch through a screen. This is often described as the illusion of presence."
Dr Heggart says this is potentially very powerful for educators.
"Rather than watching a film about the pyramids, for example, students could experience actually going to Egypt and walking into a pyramid [well, almost]," he said.
"This has the potential to significantly affect a student's learning experience."
VR tech helps pre-service teachers turn theory into practice
Is your school preparing students for technological change?
Fetching comments...


text:
Q: Parsing Twitter feed: -[__NSCFString objectForKey:] I've resolved an error some of my users were experiencing whenever my app loads JSON from Twitter:
-[__NSCFString objectForKey:] unrecognized selector

After researching, I believe the problem was the result of using an NSDictionary instead of an NSArray. My question, however, is why would some users with the EXACT same device and iOS version experience the error intermittently? Why wouldn't it either error every time for everyone or never? Does this have to do with memory in use on the device or an interruption in receiving data from the server?
EDIT:
//I have since changed statuses to an NSArray
NSDictionary *statuses = [[NSDictionary alloc] init];

statuses = [output JSONValue];

for (NSDictionary *status in statuses)
{
            Tweets *aTweet = [[Tweets alloc] init];

            //error began (fatal error) on following line
            aTweet.text = [status objectForKey:@"text"];
            aTweet.created_at = [status objectForKey:@"created_at"];
            aTweet.created_date = [dateImporter dateFromString:aTweet.created_at];

            [self.tweets addObject:aTweet];

            aTweet = nil;
 }

A: My guess would be that the software is the same but the data is different.
See if you can find out what key was being asked for.
You'll probably find that some records' json have an array at that key (maybe, when there's more than one relation), and some have a dictionary (for a relation with a single object).
I can't think of anywhere in twitter api where that's the case, but it stands to reason.

A: It depends where the data in output is coming from. You assurme your JSON data is an array of dictionaries, but it's possible that the server is returning something else, for example, if an error has occurred the server might return a dictionary with some error information in it.
You'll have to look at the Twitter API to see what data you might receive for this particular call.
https://dev.twitter.com/docs/error-codes-responses
Looking at the page above, you can use the HTTP return code to see if the request has failed, and if that's the case, you can just abort this operation.


text:
Naija Black Vulcanite Necklace
SKU: RVHBN01
6-8mm diameter
Vulcanite is a hard, moldable rubber that has been formed by "vulcanizing" natural rubber through a curing process that involves high heat and the addition of sulfur. The result is a hard substance sometimes called "ebonite" that was used in the Victorian period to make mourning jewelry, combs, ornaments and buttons.
And today these beads are more popular and collectable than ever. Thousands of these beads are in private collections around the world. The African Traders are having to go deeper and deeper into Africa to find more of these beads and many styles which were readily available just 5 years ago are no longer seen today.
There are exceptional museum collections of trade beads at the Museum of Mankind in London, the Pitt River Museum in Oxford, the Royal Museum of Central Africa in Belgium, the Murano Museum of Glass in Italy, the Tropical Royal Institute of Amsterdam, the Bead Museum in Arizona, US and the Picard Trade Bead Museum in California, US to name a few.
Short Logo Socks
Leather Fanny Pack
Tibetian Lion's Claw Bracelet
Leather Sling Pack
Leather Messenger Bag
Lion Bone Beads


Home BOX OFFICE KIM CHIU MOVIES THE GHOST BRIDE BOX OFFICE 'The Ghost Bride' Box Office: Kim Chiu's 1st solo movie is a certified hit!
'The Ghost Bride' Box Office: Kim Chiu's 1st solo movie is a certified hit!
Kim Chiu has just claimed her crown as the newest Horror Box-Office Queen, when her movie 'The Ghost Bride' earned an impressive P14.8-million opening day gross at the Philippine box-office.
Despite opening on November 1, when most Filipinos were busy at the cemetery remembering their departed loved ones, 'The Ghost Bride' managed to attract thrill-loving moviegoers and earn that high.
It's also noteworthy to think that it opened against 2 other new horror releases ('Spirits of the Glass 2' and 'Jigsaw') and faced competition versus a major Hollywood blockbuster on it's 2nd week ('Thor: Ragnarok').
Kim Chiu herself broke the good news via Instagram, and shared how happy and thankful she is for the box-office success.
Then within 5 days, 'The Ghost Bride' already has P51.5-million box-office collection.
With that gross results, the Chito Rono-directed film under Star Cinema is now guaranteed to be the next P100M-earning movie after last month's 'Seven Sundays', which debuted with P10M and grossed over P100M within its 1st week.
'The Ghost Bride', which was Graded A by the Cinema Evaluation Board, will surely pick up more millions this weekend, backed by great reviews by those who have already watched it on opening day, including this blogger.
I already said via Twitter and Instagram how I loved this wonderful horror film and how Kim Chiu impressed me by her superb lead performance as Mayen Lim.
Watched The Ghost Bride on first day & I loved it!
It's Kim's first ever solo film, not capitalizing on a loveteam, and it has been made official: she succeeded!


The Kentucky Derby, where people party for two weeks over a two-minute race, as presented by Getty Images.
Race fans Keith Stenson, Brian Martin and Jeff Allen pose in the infield during the 132nd Kentucky Derby on May 6, 2006, at Churchill Downs in Louisville, Kentucky.
A fan slides down a Slip 'N Slide in the infield prior to the 139th running of the Kentucky Derby on May 4, 2013.
Two race patrons check out the program on May 7, 2005, during the 131st running of the Kentucky Derby.
The Axe Astronauts bring a taste of space to the Kentucky Derby on May 4, 2013.
Fans slide through the mud in the infield prior to the 139th running of the Kentucky Derby on May 4, 2013.
Louisville Metro Police arrest a drunk reveler at the 136th running of the Kentucky Derby on May 1, 2010.
Race fan Josh Lile of Louisville, Kentucky, is shown after diving in the mud in the infield at the 136th running of the Kentucky Derby on May 1, 2010.
Empty beer cans are collected after the Kentucky Derby on May 6, 1995.
Mud wrestling was a popular activity in the infield for the 136th running of the Kentucky Derby on May 1, 2010.
Race fan Nelson Ricardo Martinez pours beer on Dan Malorni to reveal his Kentucky Derby 136 tattoo in the infield on May 1, 2010.
Infielders dance in the mud at the 136th running of the Kentucky Derby on May 1, 2010.
A man dodges bottles thrown by spectators as he runs the "porta-potty Gauntlet" at the 136th running of the Kentucky Derby on May 1, 2010.
Louisville Metro Police arrest a porta-potty gauntlet runner at the 136th running of the Kentucky Derby on May 1, 2010. Officers shut down the activity after one man received a bloody head wound.
Two race fans hold up signs prior to the 139th running of the Kentucky Derby on May 4, 2013.
Left: Race fan Ron Kelly stands in the infield with his derby hat during the 132nd Kentucky Derby on May 6, 2006. Right: Race fan Kari Hamilton of Columbia, South Carolina, has a fellow fan sign her body with lipstick during the 127th running of the Kentucky Derby on May 5, 2001.
Race fan Jasmine Hughes of Cincinnati, Ohio, uncoils the flexible straw of her water pack, which is filled with vodka, in the infield before the 136th running of the Kentucky Derby on May 1, 2010.
Fans dressed as video game characters attend infield festivities prior to the 140th running of the Kentucky Derby on May 3, 2014.
Left: Kentucky Derby race fans play a game of Twister during the 127th running of the Kentucky Derby on May 5, 2001. Right: Derek Judt of Blair, Nebraska, attends the 135th running of the Kentucky Derby on May 2, 2009.
Dressed as Colonel Sanders, Robin Orth of Washington, DC, poses for pictures with racing fans on the afternoon of the 137th running of the Kentucky Derby on May 7, 2011.
Race fan Tony Offutt of New Albany, Indiana, walks through the infield with a hat he made for an annual contest prior to the 129th Kentucky Derby on May 3, 2003.
Revelers Skip Copnick (left) and Charles Matasich (right) stand in the rain prior to the 136th running of the Kentucky Derby on May 1, 2010.
Left: A fan holds two beers within the infield before the start of the 131st Kentucky Derby on May 7, 2005. Right: Katie Nielsen of Reno, Nevada, watches racing from the grandstands as she shelters herself from the rain prior to the 136th running of the Kentucky Derby on May 1, 2010.
A woman sports a large, feathery hat during the Kentucky Derby on May 1, 2010.
Race fans Josh Cunningham and Jesse Maund arrive at the infield for the 136th running of the Kentucky Derby on May 1, 2010.
See more pictures from the Kentucky Derby at Getty Images.


So what really is the best thing about December for you?
For me, it's obviously the food and the festivities surrounding it. Or is it the other way round?
Buttery, moist and rich, the Paan Paan Breudher is one of the best breudhers I have tasted in my life. Scattered with plump raisins that just burst in your mouth as you bite in to it, the soft and crumbly bread is absolutely perfect with a slice of Dutch edame cheese.
Now this is a real treat. Studded with little jewels of dried and candied fruit and little bits of marzipan, the Stollen is truly a force to be reckoned with. You do get a subtle hit of spice which blends very well with the diried fruits and the soft bread and you are transported to Christmas as you always know it.
This slightly sweet bread is especially enjoyed at Christmas and is a combination of flour, plenty of butter, milk and eggs. This delightful panettone is light and fluffy with a creamy vanilla flavor and will delight your senses at every bite.
This is a true novelty. Filled with juicy, plump raisins, the bread itself is light as air and is slightly sweet. This will be the perfect side dish to accompany your Christmas breakfast toasted or plan with a generous dollop of butter melting on top. You can already visualize that now, can't you?
Apart from this, Christmas cake, love cake and other traditional Christmas goodies are also up for grabs!
The launch of Best things about December was one of the best things that we have witnessed too. We, an ensemble of bloggers, Instagrammers and Tweeps were treated to a veritable feast consisting of all the Paan Paan – The Grill's specialties that simply put a smile on everybody's faces.
So the legendary burgers and subs were back with a bang! More about those here.
Apart from that, the chocolate and coffee donuts were absolutely decadent.
The Paris Brest which I believe was new was amazingly luscious with a simple elegance. This is an incredibly soft choux pastry filled with a creamy vanilla cloud-like filling dusted with icing sugar.
The most remarkable out of all of it for me was the iconic Kimbula Banis or the Vienna roll as it has become known as of late.
Now this was no ordinary kimbula banis as within its soft, cloud-like bread it hides a secret. The secret is a wonderfully rich jaggery filling amazingly treacly and intense which comes as a lovely surprise as you bite into it. But more on that later.
The day was special as it also happens to be Mr Aboo Yoosuf's birthday! This is the force that drives the Paan Paan brand. Speaking with him, you tend to realize his obvious love for bread – his main product, his belief and dedication in giving his customers nothing but the best. For me, this is the fact that differentiates Paan Paan from any other brand out there.
Speaking of forces that drive the brand, this is me posing with Mrs Aqueela Yousuf (who by the way, insisted that she be not put in any posts/photos and is camera-shy in general) who is a force to be reckoned with herself. From marketing the brand in digital channels to basically conceptualizing catchy marketing campaigns, she is the brains that assist Mr Aboo's passion every step of the way.
Those who know me know me to be someone who doesn't support brands that I do not believe in. Ever since discovering them a few years back quite by accident, I've been a regular at their outlets and am always on the lookout for their new creations.
So when they launch a special Christmas collection of scrumptious goodies, who am I to stay silent?
So try them, let me know what you think. You don't need to spend hours and hours churning out these delicacies because Paan Paan has done that for you, just like you would make them at home.


Lamborghini posted a cryptic status update today with "Tomorrow begins a new visionary year. Follow us..." and what appears to be a grey box. Only, there's a race car drawing underneath that grey blob. A tiny bit of photoshop-fu later, and it looks like our first un-camo'd look of their new Huracán GT3.
The Blancpain numberplates and GT3 wing endplates give it away: this is definitely a livery render of their latest GT3 contender.
The Huracán is a car that was made to feature insane colors like lime green, so hooray! Lambo fans, pay attention tomorrow. Maybe they'll post the real thing.


I'll never forget the moment that our friend made up the word Experteering. Her name is Lynn, and she was hosting Derk and I on our first partnership building trip to New York. At the time, we had just started working on our new idea for a social enterprise, MovingWorlds.org. Our mission? Tackle the global talent gap while developing globally and socially-minded leaders.
We knew that to solve this talent gap, we would have to inspire a movement that connected expertise into the depths of major cities around the world, into startup hubs in emerging economies, and into the most remote areas where the challenges to progress can be the greatest.
While staying with Lynn, Derk and I were brainstorming a new word that represented the idea of giving your most valuable assets — your time, energy, skills, and experience — in a way that is good for the world AND good for you. As it turns out, intentional, impactful, skills-based volunteering can make you happier, healthier, and even help you end up with a better job. More importantly, it's also a critical tool for global development.
The word "volunteering" didn't give this idea justice. Especially in international situations where the word "Voluntourism" has created so much harm.
So when Lynn said, "just call it Experteering", as if it was the most popular word in the English language, Derk and I just stopped in our tracks. We looked at each other and smiled knowing that a new word would one day be in the dictionary.
We've spent the five years since pushing the idea of Experteering. I remember our first few meetings where we started testing this new word. For every 10 people we would talk with, 6 loved the idea right away, 3 were intrigued, and 1 would be confused and ask for an explanation. We discussed the pro's and con's of sticking to this new word, and we sought advice from others.
Coming up with a new word and trying to shift the focus of an entire industry into a more ethical, sustainable path is a challenging and time-consuming task. Advisors, partners, and funders cautioned us against trying to accomplish this while still a small startup. They said things like "It will be distracting", "You'll slow down partnerships", "You'll confuse constituents". They were right; we did all those things. After every hiccup, we continued to debate if we should stick to the challenging path of popularizing a new word to represent this new movement of skilled service overseas.
Early on we knew that the traditional idea of volunteering just wasn't enough. Volunteering has connotations of manual service and one-time efforts. In some cases, especially in international volunteering, it even does more harm than good. More importantly, most skilled professionals don't volunteer. It didn't matter if trying to popularize Experteering was going to put more bumps on our startup road. The world needs a movement that engages the smartest minds and applies them to our greatest challenges.
Creating an Experteering movement became a calling. We didn't just want to get people to volunteer more and volunteer better, we wanted to tap into the millions of people that don't volunteer to consider doing something new — to go Experteering.
Experteering has a long way to go, but it's catching on.
I remember talking to our lawyers in 2011 debating whether we should trademark the term. We decided against it. The reason? We knew that Experteering was a movement that is bigger than MovingWorlds.
If we want to save our planet from global warming, reduce pain and suffering around the globe, and eradicate poverty, we'll need to do more than we're doing. Sure, anybody can give some time and money, but Experteering is deeper than that. It's giving the world your most valuable gifts: Your heart, brain, and soul. Luckily, when you give these things, you also get to see the best the world has to offer.
Thanks for supporting us, but more importantly, thanks for supporting the Experteering movement.


Chris and I snuck off to London for a few days a couple of weeks ago with the main purpose of attending a very exciting event (hint/spoiler). But first, we spent a few days in one of my favorite cities doing a few things I had yet to cross off of my London bucket list.
Attending afternoon tea ranked high on that list, and I discovered the perfect place to do exactly that. Sanderson in West End offers just about the cutest afternoon tea I could have imagined with a Mad Hatter theme to make us feel like we stepped right into the beloved Alice in Wonderland fantasy world.
We arrived in London on a bit of a cold and dreary day, in fact we were nearly drenched walking to Sanderson in the pouring rain, so I was happy to see that the courtyard garden provided a lovely spot to warm up not only with hot tea, but with cozy blankets and plenty of heaters. Our reservation at 2:45pm meant we were seated right away, and the service was welcoming and quite friendly.
Of the wonderfully fragrant teas to choose from, I selected the tea party's namesake, Mad Hatter, and Chris tried Alice. Both were delicious, and I regret not purchasing one of each to bring back home! The loose leaf teas are available to take for £12-15 each.
We had yet to eat breakfast or lunch after stepping off the plane, so we were both ravenous and all too excited to head down the rabbit hole and try each of the goodies in the savory selection. Classic cucumber sandwiches, goat cheese croque-monsieurs, crab and herb eclairs, and smoked salmon and caviar Scotch eggs filled our bellies. We were even offered additional savory rounds (the savory plates are unlimited!) before the sweets portion of the menu.
I could have eaten quite a few of those croque-monsieurs, but I knew I needed to save room for the massive tower of confections up next. The multi-tiered serving dish offered sweets of every color, shape, and size. I felt like a kid (in a candy store!) every time I selected a different candy caterpillar, marshmallow mushroom, or drink me potion.
My absolute favorite ended up being the rich chocolate Queen of Hearts cookie soldiers, but I also loved the banana bread-and-butterfly. And the scones. And the White Rabbit's pocket watch macaron.
And just when we thought we couldn't possibly eat or drink another thing, we received a surprise ending – ice cream served in a tiny flower pot with cookie crumble topping, bits of honeycomb, and an edible flower.
Sanderson definitely nailed the Mad Hatter theme, and afternoon tea couldn't have felt more whimsical unless the Cheshire Cat himself was grinning at me from a corner in the room. At £48 per person, afternoon tea at Sanderson is perhaps a bit of a splurge, but it's perfect for a special occasion though fancy dress is not required. We noticed a pair of friends at the table next to us celebrating a birthday (or maybe an unbirthday?) and they received some special birthday treats. Occasion or not, I definitely recommend this experience!
Susan - Tiny flower pots! I'm a sucker for miniatures.


text:
Östra Kalvholmsgrund är en ö i Finland. Den ligger i Norra kvarken och i kommunen Korsholm i landskapet Österbotten, i den västra delen av landet. Öarna ligger omkring 22 kilometer väster om Vasa och omkring 390 kilometer nordväst om Helsingfors.
Öns area är  hektar och dess största längd är  kilometer i nord-sydlig riktning.

Inlandsklimat råder i trakten. Årsmedeltemperaturen i trakten är  °C. Den varmaste månaden är augusti, då medeltemperaturen är  °C, och den kallaste är februari, med  °C.

Källor

Se även
Västra Kalvholmsgrund

Öar i Korsholm
Finländska öar i Kvarken

redpajama_set_name: RedPajamaWikipedia


I do enjoy a candle.
I like the romantic ambience they create, the forgiving light they project, the luxurious smell they (can) produce. Candles of course are not just for Christmas, but for making any occasion instantly special. Like kebab night for example, which in our house is always a candle-lit occassion.
But when it comes to candles, things can go spectacularly wrong. If you've ever made the mistake of going to a high-pressure-purchase candle party you'll know the kind of thing I'm talking about. I have only one piece of advice when it comes to buying candles and it is this: Like a cheesy Christmas song; the old ones are the best.
I buy old cut glass jars whenever I see them. Why? Because they can be got from charity shops for pennies and a prettier tea light holder I am yet to find. Tall, short, fat, thin - the more mis-matched the better as far as I'm concerned. I don't even mind if they're a bit chipped. I just love getting them home and giving them a boiling hot wash in fairy liquid. My Christmas dinner table will be loaded with these lovelies next week, no light bulbs allowed.
On the mantlepiece I'm lighting up a variety of vintage candlesticks of all shapes and sizes. Mostly glass with the odd bit of brass works for me. All of these were picked up for peanuts at market stalls, charity shops or car boot sales.
Like the look but no time for rummaging? I've got just the website for you. www.theotherduckling.co.uk know how to switch on the vintage glamour alright. Their ever changing selection of unique and vintage candlesticks currently includes this tall glass number which pretty much nails the vibe don't you think?
All this talk of romantic room settings has got me feeling all emosh. In fact, whilst the lights are down and you can't see me blushing, I'd like to tell you how amazing you all are and thank you hugely for your support this year. My first 12 months as a bonafide blogger been so much fun and yet not without its frustrations. To all of you who have read, liked and shared or commented, please know that you keep me going.
May your homes be filled with love, happiness and house candy this Christmas.


The Wrigleyville eatery is a perfect spot for diners who appreciate organic and locally sourced food.
THE SHTICK: Cozy, crunchy café meets indie music venue…in Wrigleyville, of all places.
THE FOOD: Local/sustainable/organic/yadayada was the M.O. here before that became the case, oh, everywhere: Folks on special diets or those still clinging to New Year's resolutions are catered to. Vegan chilaquiles, a scramble of faux chorizo, smoked tofu, chunks of corn tortilla, vegan cheese, and salsa, sports a bit of grease, and doesn't taste especially healthy—a high compliment in this scenario. Unfortunately, a mountain of tepid, dry potatoes left much to be desired.


ダウンロード 最後のバージョン "Pepakura Designer" ために windows.
Pepakura Designer is a Hobbies アプリ for Windows devices developed by Tamasoft. The latest version of Pepakura Designer is 3.1.0a compatible with system version Windows 98 and higher. The last mod was released on 30-12-2017 and is available directly on ApkGain.com. Pepakura Designer is the property and trademark from the developer Tamasoft. Please note that we only provide the original and free package installation without any modifications. Check our "safe download" sign to get the latest report from McAfee to see if the Pepakura Designer download is completely secure.
ダウンロードとインストール 無料 windows アプリ ファイル ために Pepakura Designer.


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Let the Lamar Jackson hype begin
#10 Louisville destroyed #2 Florida State this afternoon 63-20, and quarterback Lamar Jackson put on quite a show with five touchdowns and 362 total yards. Naturally the Heisman talk dominated Twitter as many were ready to hand Jackson the trophy right now, while forgetting how Leonard Fournette seemingly had it wrapped up last season.
The other meme pumped today had many comparing Jackson to Micheal Vick, which seems like a good comparison. Vick then got into the act as well with a very gracious tweet:
Tags: Florida State Seminoles, Heisman Trophy candidates, Lamar Jackson, Leonard Fournette, Michael Vick
Ole Miss collapse caps miserable weekend for SEC
We've heard the SEC hype for years, and now after all the smack talk, fans of the conference have to take their medicine.
Ole Miss came out strong, but then utterly wilted in the second half against a resilient Florida State team.
That capped a miserable weekend for the SEC, even with Alabama's destruction of USC.
Looking back, an analyst on ESPN subbing for Mike & Mike (I can't remember his name) summed up the SEC's run pretty nicely when he pointed out that most of the success comes down to two all-time great coaches – Nick Saben and Urban Meyer. Outside of that, what can SEC fans really point to?
If you're a Georgia, Tennessee Ole Miss fan, can you really pump your chest about the SEC when your team hasn't won a title? Does it really make you feel good to pump your chest when the Alabama team that regularly crushes you is carrying the SEC banner?
Posted in: College Football
Tags: Florida State Seminoles, Nick Saben, Ole Miss, SEC, SEC overrated, Urban Meyer
College Football Week 10, NFL Week 9 Free Picks
Posted by Anthony Stalter (11/01/2013 @ 7:03 pm)
Miami vs. Florida State, 8:00PM ET
These are two very different 7-0 teams. On one side you have the Hurricanes, who trailed in the fourth quarter in each of their last two games. On the other you had Seminoles, who have scored 40 or more points in seven consecutive games and the closet thing they came to losing was beating Boston College by double-digit points. Miami's offense has been inconsistent of late and while its defense has held strong since the start of the season, no opponent has been a hurdle for Heisman candidate Jameis Winston. The Seminoles are 4-1 against the spread in their last five home games and 4-1 ATS versus a team with a winning record. Lay the points.
FREE PICK: FLORIDA STATE -21
Iowa State vs. Kansas State, 3:30PM ET
Outside of the Miami-FSU tilt on Saturday night, there aren't many sexy matchups on the Week 10 schedule. But that doesn't mean there isn't value to be had. Kansas State is 0-4 against the spread in its last four games following a straight up win while Iowa State is 7-3 ATS in its last 10 road games versus a team with a losing home record. The road team is also 3-1-1 against the spread in the last five meetings between these two teams while the underdog is 4-1-1 against the number in the last six meetings. The Cyclones are 1-6 on the year but take a closer look at their losses prior to their beat down at Baylor and last week versus Oklahoma State. They covered rather easily against Texas Tech and should have beaten Texas if it weren't for a last-second collapse. The Wildcats, meanwhile, couldn't be further from the team that opened the 2012 season winning its first 10 games. Take the points on this inflated spread.
FREE PICK: IOWA STATE +17
Saints vs. Jets, 1:00PM ET
One would think that with this being the "Ryan Bowl" that we'll see plenty of defense. But who knows the tendencies of the Ryan-led defenses better than the offenses for the Saints and Jets? Despite Jimmy Graham playing on an injured foot, Drew Brees threw for five touchdowns last week in a win over Buffalo, including two TD passes to his banged up tight end. Meanwhile, the over is 5-1 in the Jets' last six games overall, 4-1 in their last five games versus a team with a winning record and 13-5-2 in their last 20 games in November. With New York's front seven taking away the Saints' running game, look for Brees to pick on the Jets' secondary. This game won't lack for big plays.
FREE PICK: OVER 45.5
Chargers vs. Redskins, 1:00PM ET
Washington's defense has been putrid this season while allowing 32.7 points per game (31st in the NFL). In fact, the over is 7-2-1 in Washington's last 10 games after allowing more than 30 points in its previous game (its allowed over 80 points the past two weeks ago), and 7-3 in its last 10 games after allowing more than 350 total yards in its previous game. On the other side, the over is 7-1 in the Chargers' last eight games in Week 9 and 39-18-4 in their lat 61 road games. Points shouldn't be a problem on Sunday in Washington.
FREE PICK: OVER 51
Posted in: College Football, NFL
Tags: college football free picks, Drew Brees, Florida State Seminoles, free picks, Jameis Winston, jimmy graham, Miami Hurricanes, New Orleans Saints, nfl free picks, Rex Ryan, Rob Ryan, Washington Redskins
2011 College Football Program Power Rankings
Posted by John Paulsen (02/16/2011 @ 7:00 am)
Ohio State quarterback Terrelle Pryor hands off the ball to tailback Dane Sanzenbacher in the third quarter at the Louisiana Superdome in New Orleans during the 77th Annual Allstate Sugar Bowl January 4, 2011. The Buckeyes won 31-26 UPI/Dave Fornell
Almost a year ago we decided to try to quantify the stature of college football programs so that we could rank them against one another. (Click here for the 2010 Rankings.) Then our football guru, Anthony Stalter, wrote a little bit about each program and the direction that it's headed.
Here's how the total points are determined — 20 points for a national championship, 10 for a BCS title game loss, seven for a BCS bowl win, five for a BCS bowl loss, five for a BCS conference championship, three for a mid-major conference championship, two for a BCS conference runner-up and one for a major bowl appearance (i.e. a bowl that has a recent payout of more than $2 million, so for 2011 that would be Capital One, Outback, Chick-fil-A, Cotton, Gator, Insight, Holiday, Champs Sports and Alamo.) You'll see the total points in parenthesis after the team's name.
We put some thought into the point values for each accomplishment, paying special attention to how the point values are relative to one another. For example, we figured that one national championship would equate to four BCS conference championships, or three BCS bowl wins. We only looked at the last five years, as college football has increasingly become a fluid and fickle sport, and that's about how far back a recruit will go when deciding amongst a list of schools.
Lastly, since a program is so dependent on the guy in charge, we added or subtracted points if the program saw an upgrade or downgrade at the head coach position in the last five years. A max of 10 points would be granted (or docked) based on the level of upgrade or downgrade. Again, we tried to quantify the hire relative to the program's other accomplishments. For example, hiring Nick Saban is probably worth two BCS bowl appearances, or 10 points. (Sure, he might lead Alabama to more, but he also might bolt for another job in a year or two.)
So, without further ado, here are the rankings. Every year we'll go through and update the numbers based on what the program did that year (while throwing out the oldest year of data), so don't fret if your team isn't quite where you want them right now. Everyone has a chance to move up.
1. Ohio State (58)
Previous Rank: #2 (+1)
Some college football fans will take issue with the Buckeyes being No. 1 because of their "soft schedule." But this is a team that has dominated its conference five of the past six years and has finished no worse than second in each of the past six seasons. They've also appeared in two title games (though they lost both) and nine straight BCS bowl games, winning the Rose Bowl and Sugar Bowl in the past two years. They've got an interesting season coming up though. Five of their players including quarterback Terrelle Pryor, running back Dan Herron and receiver DeVier Posey will miss the first five games next year after being suspended. Can the Buckeyes stay unscathed until those players return?
2. Florida (51)
Previous Rank: #1 (-1)
If it weren't for Urban Meyer leaving the program (and their lousy 2010 season), the Gators would probably still be ranked No. 1. They have three conference championships and two national championships in two years, but the lose of Meyer hurts big-time in these rankings. But don't fret Florida fans, if Will Muschamp gets the program back on the right track then the Gators won't be at No. 2 for long.
Tags: Alabama Crimson Tide, Auburn Tigers, Boise State Broncos, Cincinnati Bearcats, Florida Gators, Florida State Seminoles, Georgia Bulldogs, Georgia Tech Yellow Jackets, Iowa Hawkeyes, LSU Tigers, Nebraska Cornhuskers, Notre Dame Fighting Irish, Ohio State Buckeyes, Oklahoma Sooners, Oregon Ducks, Penn State Nittany Lions, TCU Horned Frogs, Texas Longhorns, USC Trojans, Virginia Tech Hokies, West Virginia Mountaineers
Christian Ponder likely won't start ACC Championship Game
Posted by Paul Costanzo (12/04/2010 @ 3:34 pm)
Florida State was going to have a tough time with Virginia Tech regardless, but not having Christian Ponder on the field to start the game will make things incredibly difficult for the Seminoles.
Reports say Ponder will not start tonight's ACC Championship Game, and that E.J. Manuel will get the nod.
Ponder is battling an injury in his throwing elbow, and coach Jimbo Fisher apparently wants to give him time to heal. It seems like an odd time to be giving someone time to heal, seeing the Seminoles are playing for a conference title.
It could just be wording, however, and perhaps Ponder isn't healthy enough to play and Fisher thinks Manuel provides the Seminoles the best chance at victory under the circumstances (this is the more likely scenario). The reports do say that Ponder will be available if necessary.
Whatever the case, it might be time to get in on some late action on Virginia Tech.
Tags: ACC Championship Game, Christian Ponder, Christian Ponder injured, Florida State Seminoles, Virginia Tech Hokies
Will "Championship Week" live up to the name?
College Football Program Power Rankings
ACC race coming down to the wire
"Beamer ball" lifts Virginia Tech to ACC title


Chaat items are always fun to have and i would say it is an Indian delicacy. Chaat has become immensely popular all over the world. Papdi chaat is prepared with flatten puri called papdi, chickpeas, potato, onion, tomatoes, curd and chutneys.
Take a small mixing bowl, add cooked chickpeas and green chutney, mix well and set it aside.
Keep all the ingredients ready before starting the assembling process. First take a serving plate or bowl, place papdis as shown in the picture.
Followed by boiled potato chunks and chickpeas green chutney mixture. Next comes chopped onion, tomatoes, beaten curd and tamarind date chutney.
Garnish with nylon sev or omapodi and chopped coriander leaves on top. One final touch, sprinkle little chaat masala powder on top of it and serve immediately.
Papdis are easily available in grocery stores, you can either use store bought ones or prepare your own at home.
Increase or decrease the amount of all chutneys and sev according to your preference.
To serve this chaat as a starter in a party, prepare all the ingredients and keep them ready in a separate serving bowl. Assemble them only at the time of serving to prevent it from turning soggy.
Technorati Tags: Chaat recipes,papdi chaat,North Indian snacks,Indian street foods,chat recipes,starters,party recipes,party starters,appetizers.


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Owen-Auburn to depart Canberra
Canberra midfielder, Connor Owen-Auburn has today informed management of his desire to move back to Sydney in 2020.
Connor Owen-Auburn will depart Canberra.
Recruited from the GWS GIANTS Academy, Owen Auburn arrived in Canberra having not played a competitive football match in over a year, fracturing his foot in round 3 of 2017 playing for GWS in the NEAFL.
The 21-year-old went on to play 11 games for Canberra in his debut season, playing an integral role in the Demons' midfield.
Owen-Auburn continued to flourish in 2019 with his best performance coming in Round 4, collecting 20 disposals (11 contested), six marks and four inside 50s, claiming the NEAFL's Round 4 Rising Star nomination.
He played 26 games in his two seasons at Canberra.
"Connor has been an outstanding contributor to Canberra for the last two years, and we respect his decision to return home and be closer to his family," Canberra General Manager of Football, Shaun Young said.
"We have been in constant communication with Connor throughout the season, and we would like to acknowledge the way he has conducted himself throughout the year.
"As always, Connor has put the team first, and he will forever be a part of our family."


We teamed up with the Greenbelt Foundation for an exploration of how climate change affects the health of Ontarians. Key health risks, from extreme heat, water- and foodborne illness, and injury and mental health from severe storms can be reduced with specific actions by individuals and communities.
Health in a Changing Climate explores the impacts that climate change is having on our health. It is a collaboration with the Friends of the Greenbelt Foundation, and written by two of our staff, Medical Officer of Health, Dr. Charles Gardner, and Morgan Levison, formerly Climate Change Lead.
Read the report Climate Change and Health: Impacts and Opportunities by Dr. Gardner and Morgan Levison, and the supplementary fact sheet.


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TOP STORIES / Science
Hydroxychloroquine: Using anti-malaria drug is a risky business
US President Donald Trump, his Brazilian counterpart Bolsonaro and Tesla boss Elon Musk — all swear by the anti-malaria drug as an antidote to coronavirus. But studies show it is ineffective, and potentially dangerous.
US President Donald Trump has advocated the benefits of hydroxychloroquine since March now. And for the past week, he has been taking the anti-malaria drug on a daily basis, because he "thinks it is good."
The US Food and Drug Administration (FDA) warned against the supposed miracle cure at the end of April. Researchers said there was no substantial proof it was effective in combating the coronavirus.
Defiant demonstration
Trump's Brazilian counterpart, Jair Bolsonaro, has similarly propagated the the use of hydroxychloroquine. However, after visiting Trump in Florida in March, 20 members of his delegation tested positive for COVID-19, resulting in a PR disaster.
But as a former athlete and paratrooper, Bolsonaro claimed the "minor flu" wasn't going to seriously affect him. The president continues to ignore social distancing and continues to shake hands.
In order to protect the population though, he ordered military laboratories to produce millions of tablets. And he fired two health ministers who refused decree the prescription of the drug to COVID-19 patients.
Brazilian doctors fear that hundreds of patients died at home in the past few weeks after taking the potential cure without medical supervision. However, the Health Ministry is still expected to make treatment with the drug its official policy this week.
Where does the enthusiasm come from ?
The active ingredient in the well-known malaria drug Resochin, chloroquine, with its derivative, hydroxychloroquine, have been used to prevent and treat malaria for decades.
In tests conducted in China and France, the active substance chloroquine was said to have inhibited the proliferation of the novel coronavirus in cell cultures. That was taken to indicate that chloroquine could reduce the viral load in patients experiencing a severe progression of the disease. It was thought the active ingredient could therefore be used as an antiviral drug, the researchers reported.
A recent study (albeit not peer reviewed), found that the mortality rate after treatment with hydroxychloroquine is significantly higher at 28%. In COVID-19 patients who were treated without the malaria drug, the mortality rate was 11%. The researchers evaluated the case files of 368 patients at US hospitals for military veterans.
Despite concerns about the methodology of the studies, their significance, and possible side effects, clinical tests with the well-known active substance have now been carried out in other places, too.
Read more: Coronavirus: Paper towels and coins beat hand dryers and banknotes
European biotech giant develops sought-after rapid test
Fatal study in Brazil
A small phase II study in Brazil, in which 11 patients died of fatal arrhythmias or heart muscle damage, shows how risky high-dose treatment of COVID-19 patients with chloroquine can be, especially in combination with the antibiotic azithromycin or other drugs.
The study, which was financed by the Brazilian government and whose preliminary, not peer reviewed, results were published on the scientific portal MedRxiv, involved 81 hospital patients. Altogether 440 patients were ultimately supposed to participate in the phase IIb study "CloroCovid-19."
Marcus Lacerda's team from the Tropical Institute in Manaus in the Brazilian state of Amazonas administered a dose of 450 milligrams of chloroquine twice a day for five days (total dose 2.7 grams) to about half of the patients. The other patients were prescribed a dose of more than 600 milligrams (total dose 12 grams) for 10 days. There was no placebo group.
Too high a dosage?
Normally, malaria drugs are used at a lower dosage and only for a few days. In Brazil, the dosage was even higher than suggested by the Chinese authorities and the US Center for Disease Control and Prevention (CDC).
The health authority of the Chinese province of Guangdong had recommended treatment with 500 mg twice daily for 10 days (total amount 10 grams). The CDC recommended an initial dose of 600 mg plus another 300 mg after 12 hours, followed by 300 mg twice a day on days two to five (total dose 3.3 grams).
The physicians in Brazil noticed arrhythmia (significant extension of the so-called QT interval) within two to three days in patients receiving the high dose. On the sixth day of the trial, 11 patients died and the phase II trial was stopped immediately.
Were warnings ignored?
Internal medicine specialists had already warned in the Canadian Medical Association Journal about the dangers of QTc prolongation in the electrocardiogram when using chloroquine and hydroxychloroquine — especially in combination with the antibiotic azithromycin.
According to that report, the combination can lead to hypoglycemia (abnormally low blood sugar levels), restlessness, confusion and delusions, in addition to cardiac arrhythmia. An overdose can lead to epileptic seizures, coma and cardiac arrest, the report says.
Read more: Did coronavirus really originate in a Chinese laboratory?
Disastrous drug cocktail
Many COVID-19 patients are significantly older than malaria patients and often have pre-existing conditions. In such a risk group, a high-dose treatment with chloroquine is presumably much more likely to lead to damage to the heart muscle and to severe cardiac arrhythmia.
As there was no placebo group in the Manaus study, it is difficult to see exactly what proportion of deaths were caused by chloroquine. This is because all patients were additionally treated with the antibiotic azithromycin, which also extends the QTc interval. Some patients had also taken oseltamivir (Tamiflu), which can also have a negative effect on cardiac rhythm.
Humans as guinea pigs?
In principle, the two active ingredients chloroquine/hydroxychloroquine are well-known and safe. The drug Resochin, developed by the German pharmaceutical and chemical group Bayer, has been successfully used as a malaria drug or prophylaxis since the 1930s.
However, the risks and side effects have been known for a similar length of time. Even such tried-and-tested drugs can cause severe damage if taken in extremely high doses, as wrong self-medication or by possibly endangered groups of people.
Investigations must now show whether the clinical trial in Brazil negligently overdosed patients or ignored warnings. The fatal outcome of the phase II study in Brazil coincides with a TV discussion, widely perceived as extremely racist, between two French doctors who wanted to turn Africa into a huge laboratory for coronavirus vaccine testing.
They cited the lack of resources on the continent and hence the lack of protection against the virus as the reason for their proposal. They said studies on AIDS had been done there on the same grounds. The provocative discussion caused worldwide outrage.
Clinical tests remain necessary
In the search for a vaccine or drug — also against the new coronavirus SARS-CoV-2 — clinical tests are nevertheless essential. Only through the cooperation of manufacturers, clinics and medical institutions can it be clarified whether a drug actually shows the desired therapeutic effect (efficacy), whether it is safe or whether side effects occur (tolerability), how exactly it has to be dosed (dose finding) and whether, in the end, the benefits actually outweigh the risks.
Phase II studies usually involve 100 to 500 volunteer patients as test persons. In most countries, there are strict legal requirements for the conduct of clinical trials in order to limit the risk to the trial participants. In most countries, the volunteers' consent to participate must be given in writing in advance.
The treating physician is obliged to inform each participant in the trial in detail about the possible benefits and all risks — but risks and side effects can never be excluded.
Due to new research, this article has been updated since its original publication.
Researchers and their self-experiments
An oral vaccination against coronavirus
Courage, curiosity or complete hubris? It's probably a mixture of all these things that causes many scientists to test their own inventions on themselves first. According to the Global Times, a Chinese doctor not only developed an oral vaccine against the SARS-CoV-2 but also tried it out himself. So far, he hasn't seen any side effects.
Laughing-gas party with Humphry
Scientific knowledge and private pleasure can go hand in hand. The British chemist Sir Humphry Davy experimented with nitrous oxide between 1795 and 1798. With the help of his self-experiments, he discovered not only the pain-relieving effect of the gas but also its intoxicating qualities.
Discoverer of UV radiation
The German physicist Johann Wilhelm Ritter not only discovered ultraviolet radiation in 1801, but also invented the first battery the following year. Ritter was also interested in galvanism — a term applied to muscle contractions caused by electric shocks. The fact that he died at the age of 33 is said to have been due in part to the galvanic self-experiments with which he maltreated his body.
Freud on cocaine
The Austrian psychologist and doctor Sigmund Freud is known as the founder of psychoanalysis. His methods are still used, discussed and criticized today. Less well known is that Freud researched the effects of cocaine during his time as a doctor at the Vienna General Hospital. Published letters show that Freud himself consumed coke for a long time and in large quantities.
Death from yellow fever
"I believe that I am on the trail of the true pathogen," wrote the American physician Jesse Lazear on September 8, 1900, in a letter to his wife. Lazear researched malaria and yellow fever. He confirmed that the latter is transmitted by mosquitoes. To study the disease, he intentionally allowed himself to be stung, fell ill and died 17 days after writing the letter. Lazear was only 34 years old.
The fastest man on earth
John Paul Stapp became known as the "fastest man on earth" because of his research on the effects of acceleration forces on the human body — including his own: He had himself accelerated on a so-called rocket sled up to more than 1,000 kph (621 mph) and decelerated completely in 1.4 seconds. It is the highest acceleration that a human being has ever voluntarily withstood.
Secret heart catheter
Werner Forssmann was already considered a troublemaker during his medical training. The German surgeon was determined to prove that a long, flexible catheter could be inserted safely from the crook of the arm to the heart. Although his superiors had expressly forbidden him to carry out the experiment, in 1929 Forssmann was the first person to try it out — on himself. Secretly, of course.
Nobel Prize winner — posthumously
The Canadian physician Ralph Steinman fell ill with pancreatic cancer and underwent an immunotherapy he developed himself. According to his physician, this therapy was unable to prevent Steinman's death, but — contrary to the prognosis — could possibly have prolonged his life by over four years. Steinman died in 2011, a few days before the Nobel Prize was awarded, which he received posthumously.
Author: Julia Vergin (fs)
DW recommends
Subscribe to Corona Compact — DW's newsletter tracking coronavirus in Asia
As Asia risks once again becoming the epicenter of the pandemic, with the number of infections rising in many countries across the region, DW's coronavirus newsletter is here to provide the answers you are looking for. (06.04.2020)
Could an existing drug help against the new coronavirus?
Medical researchers are working hard to find a vaccination against the novel coronavirus. But parallel to these efforts, the repurposing of existing drugs could shorten lengthy clinical trial phases and save lives. (09.04.2020)
What you need to know about the coronavirus
What are the symptoms of COVID-19 and how can you protect yourself? What's the latest status on infection rates and how is the international community responding? Here's an overview of the latest news and information. (27.02.2020)
MedRxiv: Outcomes of hydroxychloroquine usage in United States veterans hospitalized with Covid-19
Author Alexander Freund
Related Subjects Brazil, Coronavirus
Keywords chloroquine, coronavirus, hydroxychloroquine, malaria, anti-malarial, side effects, phase II studies, cardiac arrhythmia, COVID-19, SARS-CoV-2, Brazil
Permalink https://p.dw.com/p/3bAgV


The main goal of the current study was to elucidate the molecular mechanisms implicated in central cannabinoid receptor 1 (CB1R)-evoked sympathoexcitation/pressor response. In pursuit of this goal, the candidate first characterized the centrally elicited hemodynamic effects of CB1R activation (WIN55,212-2) in a conscious rat model. The results showed that the pressor response elicited by central CB1R stimulation was associated with enhanced neuronal activity of presympathetic neurons in the rostral ventrolateral medulla (RVLM). The findings of multiple in vivo and in vitro studies have suggested a functional crosstalk between central CB1R and orexins. Therefore, the candidate hypothesized that orexin-A/orexin receptor 1 (OX1R) signaling in the RVLM is essential for the central CB1R-mediated pressor response. In support of this hypothesis, central CB1R activation elevated orexin-A level in the RVLM and inhibition of orexin-A/OX1R signaling abrogated the CB1R-evoked pressor effect. On the other hand, central orexin-A/OX1R-evoked pressor response was not affected by prior blockade of central CB1R. Colocalization studies have unraveled close proximity of orexin-A/OX1R to CB1R immuno-reactive neurons and punctate structures in the RVLM, which support the pharmacological findings. Furthermore, the present study delineated a novel role for PI3K/Akt/ERK1/2 signaling in RVLM and nucleus tractus solitarii (NTS) in the sympathoexcitation elicited by central CB1R activation in conscious rats. The latter findings inferred a causal role for a down-regulated PI3K/Akt signaling in the RVLM and NTS in the central CB1R-evoked pressor response. This conclusion is supported by the exacerbation of WIN55,212-2 evoked pressor response following PI3K/Akt inhibition (wortmannin). By contrast, ERK1/2 phosphorylation was enhanced in the same neuronal pools and the pharmacological and molecular studies suggest that this effect, which is mediated, at least partly, via the reduction in PI3K/Akt signaling, contributes to the central CB1R-evoked pressor response. Finally, the findings demonstrated that direct CB1R activation in the RVLM enhanced the activity of two distinct neuronal pools (catecholaminergic and nitroxidergic), which are essential for the central regulation of cardiovascular function. These latter neuronal responses may be linked to the modulation of brainstem GABAergic neurotransmission and subsequently to the central CB1R-evoked sympathoexcitatory and pressor response. The findings yield new insight into a functional crosstalk between CB1R and OX1R signaling in the RVLM, a neuronal pool that is heavily implicated in blood pressure control and in hypertension.
Ibrahim, Badr Mostafa Sadek. Mechanisms for central cannabinoid receptor 1 evoked sympathoexcitation/pressor response in conscious rats. Doctoral Dissertation. East Carolina University, January 2010. The Scholarship. http://hdl.handle.net/10342/3181. April 21, 2019.
Ibrahim, Badr Mostafa Sadek, "Mechanisms for central cannabinoid receptor 1 evoked sympathoexcitation/pressor response in conscious rats" (Doctoral Dissertation., East Carolina University, January 2010).
Ibrahim, Badr Mostafa Sadek. Mechanisms for central cannabinoid receptor 1 evoked sympathoexcitation/pressor response in conscious rats [Doctoral Dissertation]. Greenville, NC: East Carolina University; January 2010.


The M&T Bank Draft Day Challenge has been taking your choices for who you believe will be Buffalo's top draft choice. Fans have until 6 pm Thursday to submit their vote for a chance to win a Bills Game Day Experience. Here is where the votes stand to this point with respect to the most popular selections.
Naturally with several contestants providing the same answer winners will be selected at random for the chance to win a Bills game day experience package for two with all-inclusive M&T Bank Club tickets, pre-game field passes and a Bills Alumni meet and greet opportunity along with a Bills helmet for each winner.
So hurry up and get your vote in if you haven't already. Time is running out.
The winners of the fourth annual M&T Bank Draft Day Challenge were announced by the Bills on Thursday.
Each of the five winners correctly selected former Clemson University running back C.J. Spiller as the Bills first pick of the NFL Draft.
Nearly 7,000 fans participated in the buffalobills.com online contest and 372 fans correctly predicted Spiller as Buffalo's top selection in this year's draft.
As part of the prize, the winners will meet C.J. Spiller after the Bills Open Practice on Saturday, June 5th. In addition to the meet and greet, they will each receive a special tour of the training facility and a C.J. Spiller autographed jersey.
The M&T Draft day challenge is winding down. Get your picks for the Bills top draft choice in before 1pm. To enter check the top banner on the home page of Buffalobills.com.