Neil Harris has had a varied career in finance and communications both in Dublin and around the world before returning to full-time study back in 2014 to follow his ambition of being a physiotherapist. As well as learning the latest evidence based assessment and treatment approaches, he worked in many different hospital settings including intensive care, stroke and surgical wards, acute mental health admissions and musculoskeletal outpatient departments. He graduated with a First Class Honours degree in BSc Physiotherapy from the University of Brighton in 2017.
Neil is passionate about helping people and puts the patient at the heart of every consultation, taking time to understand the history of a presenting condition and the impact this has on daily life. Having established what the patient wants to achieve, those goals will be the focal point to discuss and agree an individual treatment plan that fits with the patient's lifestyle. He has developed a particular clinical interest in shoulder, back and foot conditions but can help with any musculoskeletal problem.
Having played semi-professional soccer in his earlier years, Neil now enjoys the more social aspect of playing 5-a-side with friends. He also makes time for running, cycling, swimming, going to the gym and just generally being active and outdoors as often as possible. Born in Norwich in the UK, Neil has travelled extensively but now calls Ireland home and has spent time getting involved in the community by volunteering with the Special Olympics.
Neil works from both our Blanchardstown and Castleknock clinics in Dublin. Call us on 015310007 to book an appointment with Neil.


WINSTON-SALEM, N.C. -- The day after 35-year-old Olivia Florez was killed in a hit-and-run in Winston-Salem, her family couldn't bear the thought of her dying alone. Tonight, they know that wasn't the case.
"There were people there, there was a witness there who was really nice too and he stayed with her," said Florez's half-sister, Tammy Woodel.
Police say around 7:30 p.m. on Nov. 14, 2018, Florez was driving a Universal Taxi Cab when she pulled out of a shopping center and started southbound on New Walkertown Road. There, a 2006 Infiniti collided with Florez, killing her. The driver of the other car ran away before police could get there.
Family members say Florez was driving the cab to make more money for her children. At the time, her two girls were ages 2 and 15, and her stepsons were 10 and 11.
"Nothing will bring her back. And her kids won't have a mom anymore," Maria Ramirez, Florez's stepsister, said through tears on Nov. 15.
On Friday, police announced an arrest in the case. Ravon Walser Rousseau, 26, who was already in the Forsyth County Detention Center on unrelated charges, now faces several additional charges in connection to Florez's death. They include second-degree murder, felony hit-and-run, speed competition, driving with license revoked, careless and reckless driving, fictitious tag, no insurance, passing in the center turn lane and exceeding the posted speed limit.
Although the last four months haven't been easy, joy did come in the form of Florez's youngest daughter, Aleya, being baptized on March 8.
"We tried to do everything like she wanted," Woodel said.
Woodel added that before her death, Florez had picked out the dress Aleya wore that day.
"Aleya was standing in the middle of the floor hollering mommy and that was difficult," she recalled.
Aleya turned 3 in January. Florez's other daughter, Imani, turns 16 in April.
"She was only 35. She was our baby sister and she was more like my daughter," Woodel said, of Florez.
Woodel added that their mother died when Florez was 3 years old. She is now writing a book about Florez – including some of their greatest memories – which Aleya will have to remember her by.
According to the North Carolina Judicial Branch, Rousseau is facing several other unrelated charges, including felony assault on a law enforcement officer with a firearm, felony possession with intent to distribute cocaine, misdemeanor possession of drug paraphernalia, reckless driving and resisting a public officer.
Rousseau was also initially charged with two counts of first-degree attempted murder in June 2016, when two Winston-Salem officers radioed in saying they were taking on gunfire at city yard, where officers perform maintenance on and fill the gas tanks of their patrol vehicles. Officers responded and located Rousseau, as well as three handguns and drugs in the vicinity. Police later located the vehicle Rousseau was driving, where they found ammunition, firearm cases and paper targets. The discovery of the new evidence raised questions about if Rousseau was intentionally targeting the officers and his bond was reduced from $1,000,000 to $2,500. He was later released.
Rousseau is due in court to answer for the second-degree murder and hit-and-run charges on April 4.


text:
Paramount Almost Made A TV Adaptation Of The Monster Squad
by Jessica James
We Got This Covered
Rebooting or adapting 1980s television and movies is hot business right now, from Child's Play to the troubled Lost Boys series, as well as a new prequel for Gremlins. One property that didn't get the green light though is The Monster Squad, as it's been revealed that a planned TV adaptation of the 1987 movie couldn't get off the ground at Paramount. According to original director Fred Dekker, the studio were interested in reviving the much-loved film, but development was limited.
Dekker spoke to Moviefone about why The Monster Squad series didn't happen, commenting as so:
"I'll be completely honest, Shane Black and I have both been approached about adapting The Monster Squad for television. Was it my first choice? No. But I'm a big fan now of long form television. And figuring out a way to take Monster Squad and turn it into
See full article on We Got This Covered
Monster Squad (1976)
Fred Dekker (I)
Shane Black (I)

redpajama_set_name: RedPajamaCommonCrawl


WECREATE | KENYA Women's Entrepreneurial Center of Resources, Education, Access, Training for Economic Empowerment Center is now open in Nairobi ! The WECREATE project is a grand global vision to not only provide female entrepreneurs and women led enterprises tools and opportunities to make their startups booming successes but also provide a physical space that nourishes and supports a local, national and international ecosystem.
This is an open invite to anyone who would want to come and visit the WECREATE | KENYA Center, network and find out more about our programming and work! Women are encouraged to bring their families and friends as well!
It will be a celebration Kenyan culture, cuisine and our outstanding entrepreneurial community. We will also be having some showcases from entrepreneurs, come ready to shop! We have a play area for the kids too.
During the Global Entrepreneurship Summit in July, President Obama announced the development of the WECREATE Women's Entrepreneurship Center, in partnership with Caterpillar, Inc., Caterpillar Foundation, Startup Cup, and the African Women's Entrepreneurship Program (AWEP), Kenya chapter. The brand-new Women's Entrepreneurial Centers of Resources, Education, Access, and Training for Economic Empowerment (WECREATE)|Kenya Center is preparing for a soft opening during Global Entrepreneurship Week (GEW), November 16-20. The Center will provide women with tailored, experience-based education and resources to support their specific needs in starting, scaling, and growing businesses.
2:00 p.m. – 4:00 p.m. | Mentor Certification – An invitation-only program aimed at expanding entrepreneurial mentorship & the Build-A-Business Workshop, a mentor-driven program designed to visually guide entrepreneurs and aimed at expanding business ideas, teaching business model design and identifying solutions that accelerate revenue growth.


Classical biological control of the exotic, invasive toadflaxes Linaria vulgaris (L.) Mill. and Linaria dalmatica Mill. has had both successes and failures. One of the new challenges land managers face is the apparent increase in vigor shown by naturally occurring hybrid populations of the two toadflax species. This has presented practical problems because managers now are unable to decide which weevil species to use on these hybrids: Mecinus janthinus, which is found on L. vulgaris, or M. janthiniformis which has preference for L. dalmatica. This key question was addressed using olfactometer experiments to determine if the volatile profile for each plant establishes host fidelity for the naturally-occurring associated Mecinus species. Adults of both insect species were paired in cages on clones of naturally occurring and synthetic reciprocal cross hybrids and the parent toadflax species to quantify mating events and to determine the number of offspring produced on clones of each plant type of plant in incomplete randomized blocks. We did this using both intraspecific and interspecific pairs of Mecinus species to determine how many offspring are produced by intraspecific adults and also to explore the possibility of establishing a hybrid weevil population using clones of each plant type. Host plant preference for both Mecinus species is influenced by olfactory responses, but this was only evident for adult females. Our first series of no-choice experiments with intraspecific mating pairs indicated that M. janthiniformis is more successful in terms of offspring produced for all types of hybrid toadflax tested. The results also showed that M. janthinus had a higher percentage of survival on all types of hybrids. As expected each Mecinus species performed best on its natural host plant. The results of our second series of no-choice experiments suggest that these two weevil species can produce viable interspecific offspring on clones of most of the plant types evaluated. This suggests that the newly described M. janthiniformis is very similar to M. janthinus and the separation between the two species is controlled at least in part, by olfactory cues from the favored host. In the future, land managers can better decide which Mecinus species to use based on whether the hybrid weed species is influenced more by L. vulgaris, or L. dalmatica.


Edacoto-Blue Marbled Pen & Pencil Set In Box-C.a 1930s. This set is made of Galalithe. It was used in France in the 1930s to make pens, jewelery and other things. The set in in beautiful condition. There are no cracks or chips in the cap or the barrel of either the pen or the pencil. The color is truly incredible. The pen has a very nice fine, super flex nib which writes smoothly. The pen measures 4 1/2" long when closed and the pencil measures 4 3/16" long.
They are both in working order. The nib and feed of the pen has been cleaned and a new sac has been installed. The pencil mechanism works well.


You are here: Home / About My Site! / Babble.com / Does Motherhood Make Us Mean?
Does Motherhood Make Us Mean?
I once participated in a perception exercise with 19 coworkers as part of a team-building program. We were each given 19 small pieces of paper and asked to anonymously describe each fellow employee with a single adjective. The tiny papers were then collected and distributed face down to their rightful new owners.
Carefully situating each 3×3 paper into a perfect pile, I wondered what these folks — the people I saw more than my own friends — thought of me.
I'll admit I was proud of myself. I'd somehow managed to stay nice in a professional environment that was anything but. And I suppose if I had to describe myself in one word, I'd use the same. I may not have been the smartest or the boldest, the prettiest or the cleverest, but I was always, always nice.
That was, until I became a mom.


text:
La ciclosporina és un fàrmac immunosupressor àmpliament utilitzat en el trasplantament d'òrgans per evitar el rebuig de trasplantament. Redueix l'activitat del sistema immunitari interferint amb l'activitat i el creixement dels limfòcits T.

Va ser inicialment aïllat del fong Tolypocladium inflatum trobat en unes mostres de terra de Noruega l'any 1969, per Hans Peter Frey. La majoria de pèptids són sintetitzats pels ribosomes, però la ciclosporina és un pèptid no ribosòmic cíclic d'11 aminoàcids que conté un D-aminoàcid, el qual és rarament trobat en la natura.

Es troba en la llista model de Medicaments essencials de l'Organització Mundial de la Salut, que conté els medicaments més importants que es necessiten en un sistema sanitari bàsic.

Usos mèdics
La ciclosporina ha estat aprovada per la FDA per impedir i tractar la malaltia de l'empelt contra l'hoste en trasplantaments de medul·la òssia i per impedir el rebuig en trasplantaments de ronyó, cor i fetge. Als EUA el seu ús també està aprovat pel tractament d'artritis reumatoide i psoriasi, com una emulsió oftàlmica pel tractament d'ulls secs i com a tractament per la queratitis nummular anterior persistent secundària a queratoconjuntivitis adenoviral.

A més d'aquestes indicacions, la ciclosporina també es fa servir per al tractament de dermatitis atòpica severa, malaltia de Kimura, piodèrmia gangrenosa, urticària autoimmunitària crònica, èczema dishidròtic, dermatomiositis resistent, prurigen nodular, mastocitosi sistèmica aguda i determinades lesions eritematoses cutànies recurrents de la malaltia de Behçet. Administrada per via oral, ha demostrat ser d'utilitat contra èczemes dels palmells de les mans refractaris a la medicació habitual.

La ciclosporina ha estat utilitzada per tractar pacients amb colitis ulcerosa aguda greu i urticària autoimmunitària que no responen al tractament amb esteroides. En certs casos, pot ser una alternativa a la colectomia. Aquest fàrmac també es fa servir com a tractament de l'uveïtis recidivant posterior o intermèdia no infecciosa.

La ciclosporina A s'ha emprat com a fàrmac de primera línia en limfomes de cèl·lules T cutanis molt específics amb bons resultats a llarg termini.

A dosis baixes, administrades de forma perllongada, millora la simptomatologia de la cistitis intersticial resistent a les usuals línies terapèutiques.

És de vegades prescrita en casos veterinaris, particularment en casos extrems d'anèmia hemolítica relacionada amb el sistema immunitari. Les seves indicacions en Veterinària també inclouen alguns tipus de pèmfig, la fístula perianal canina, l'adenitis sebàcia, la pododermatitis crònica o l'otitis externa proliferativa crònica.

El BOE va publicar el 13 de juny de 2020 el llistat de medicaments que el Ministeri de Sanitat considera "essencials" per combatre el coronavirus, entre els qual està l ciclosporina.

Efectes adversos
Les reaccions adverses greus poden incloure inflamació de les genives, convulsions, úlceres pèptiques, pancreatitis, febre, vòmits, diarrea, confusió, hipercolesterolèmia, dispnea, entumiment i formigueig particularment dels llavis, pruïja, pressió arterial alta, retenció de potassi que possiblement pot causar hiperpotassèmia, disfunció dels ronyons i el fetge (nefrotoxicitat i hepatotoxicitat), sensació de cremor a les puntes dels dits, i una vulnerabilitat augmentada a les infeccions fúngiques i víriques oportunístiques. En resum, és nefrotoxic, neurotoxic, augmenta el risc de carcinoma escamós i infeccions, i sovint causa hipertensió (a causa de la vasoconstricció renal i la reabsorció incrementada de sodi). L'últim cas pot resultar en episodis cardiovasculars adversos seriosos; per això és recomanat que els prescriptors del fàrmac trobin la dosi eficaç més baixa per les persones que requereixen tractament a llarg termini. La ciclosporina també causa un creixement del cabell anormalment ràpid que no s'observa emprant el tacrolimus (un altre inhibidor de la calcineurina).

L'ús de la ciclosporina posterior al trasplantament renal és associat amb hiperuricèmia i, en alguns casos, gota. Això és a causa de la disminució en la filtració glomerular induïda per la ciclosporina que causa retenció d'àcid úric. L'ús d'azatioprina com una alternativa ha demostrat reduir la incidència d'artropatia gotosa.

En persones afectes d'anèmia aplàstica o sotmeses a trasplantaments, han estat descrits casos de trombosi del si venós cerebral relacionats amb la presa oral de ciclosporina.

S'ha observat que una forma alternativa del fàrmac, la geclosporina o ciclosporina G (OG37-324), és molt menys nefrotoxica que la ciclosporina estàndard (ciclosporina A). La ciclosporina G (massa molecular 1217) difereix de la ciclosporina A en l'aminoàcid de la segona posició, on una L-norvalina reemplaça l'àcid α-aminobutíric. Està classificada per l'Agència Internacional de Recerca sobre el Càncer en el Grup 1 de cancerigens (evidència suficient de carcinogenicitat en éssers humans). Una altra variant, la ciclosporina E, presenta in vitro i en un medi aquós uns efectes tòxics lleugerament menors.

Mecanisme d'acció
L'efecte més important de la ciclosporina és minvar l'activitat dels limfòcits T i la seva resposta immunitària.

La ciclosporina s'uneix a la proteïna citosòlica ciclofilina dels limfòcits, especialment dels limfòcits T. Aquest complex de ciclosporina i ciclofilina inhibeix la calcineurina, la qual, sota circumstàncies normals, és responsable d'activar la transcripció de l'interleucina-2 (IL-2). En els limfòcits T, l'activació del receptor T de la cèl·lula normalment augmenta la quantitat de calci intracel·lular, el qual actua mitjançant la calmodulina per activar la calcineurina. Aleshores la calcineurina desfosforila el factor de transcripció nuclear activat dels limfòcits T (NFATc), el qual es trasllada al nucli del limfòcit T i augmenta l'activitat dels gens que codifiquen IL-2 i les citocines relacionades. La ciclosporina impedeix la desfosforilació de NF-ATc unint-se a la ciclofilina. També inhibeix la producció de limfocina i l'alliberament d'interleucina i, per tant, causa una funció reduïda dels limfòcits T efectors. No afecta l'activitat citostàtica.

La ciclosporina afecta els mitocondris impedint que s'obri el porus de transició de permeabilitat mitocondrial, per tant inhibint l'alliberament de citocrom c, un potent factor d'estimulació apoptòtic. Aquest no és el mecanisme primari d'acció per l'ús clínic, però és també un efecte important per a la recerca sobre l'apoptosi.

La ciclosporina s'uneix a la proteïna ciclofilina D (CypD) que constitueix part del porus de transició de permeabilitat mitocondrial (MPTP), i inhibeix la ruta metabòlica de la calcineurina fosfatasa.
El MPTP és trobat en la membrana mitocondrial dels miòcits cardíacs i introdueix ions de calci (Ca2+) als mitocondris. Quan el canal està obert, el Ca2+ entra als mitocondris, desequilibrant el potencial de transmembrana. Sense regulació adequada, això pot contribuir a disfunció i inflament mitocondrial. Per permetre la contracció normal, el Ca2+ intracel·lular augmenta, i el MPTP s'obre, introduint Ca2+ als mitocondris. La calcineurina és un fosfatasa activada pel Ca2+ que regula la hipertrofia cardíaca. La regulació ocorre a través de NFAT, el qual quan és desfosforilat, s'uneix a la GATA i forma un factor de transcripció amb habilitat de controlar el gen hipertròfic (2). L'activation de la calcineurina causa un increment de la hipertròfia.

Metabolisme i activitat del metabòlit
La ciclosporina és altament metabolitzada pel fetge en éssers humans i animals després de la ingestió. Els metabòlits resultants inclouen ciclosporina B, C, D, E, H, L, entre d'altres. Els metabòlits de ciclosporina tenen activitat immunossupressora més baixa que la CsA (aproximadament <10%), i estan associats amb una nefrotoxicitat més alta.

Biosíntesi
La ciclosporina és sintetitzada per una sintetasa de pèptids no ribosòmics, ciclosporina sintetasa. L'enzim conté un domini d'adenilació, un domini de tiolació, un domini de condensació, i un domini de N-metiltransferasa. El domini d'adenilació és responsable del reconeixement del substrat i l'activació de l'enzim, mentre que el domini de tiolació uneix covalentment els aminoàcids adenilats a la fosfopanteteïna i el domini de condensació allarga la cadena del pèptid. Els substrats de la ciclosporina sintetasa inclouen L-valina, L-leucina, L-alanina, glicina, àcid 2-aminobutíric, 4-metiltreonina, i D-alanina, el qual és l'aminoàcid que començar en el procés biosintètic. Amb el domini d'adenilació, la ciclosporina sintetasa genera els aminoàcids acil-adenilats, llavors uneix covalentment l'aminoàcid a la fosfopanteteïna a través d'un enllaç tioèster. Alguns dels aminoàcids de substrat esdevenen N-metilats per l'acció de la S-adenosil metionina. El pas de ciclizació allibera la ciclosporina de l'enzim. Els aminoàcids com D-Ala i butenil-metil-L-treonina indiquen que la ciclosporina sintetasa requereix l'acció d'altres enzims com la D-alanina racemasa. La racemització de L-Ala a D-Ala és depenent del piridoxal fosfat. La formació de butenil-metil-L-treonina és efectuada per una butenil-metil-L-treonina policètid sintasa que utilitza acetat o malonat com el seu substrat.

Història
L'efecte immunosupressor de la ciclosporina va ser descobert l'any 1972 per empleats de Sandoz (ara Novartis) a Basel, Suïssa, en una prova de cribratge de supressió del sistema immunitari dissenyada i implementada per Hartmann F. Stähelin durant un treball de recerca de nous antifúngics. L'èxit de la ciclosporina per impedir el rebuig va ser demostrat en trasplantaments de ronyó per R.Y. Calne i col·legues a la Universitat de Cambridge i en trasplantaments de fetge fets per Thomas Starzl a l'hospital de la Universitat de Pittsburgh. El primer pacient, el 9 de març de 1980, va ser una dona de 28 anys. La ciclosporina va ser subsegüentment aprovada per l'ús l'any 1983.

Formulacions
El fàrmac exhibeix una solubilitat molt baixa en aigua, i, en conseqüència, les formes de suspensió i emulsió del fàrmac han estat desenvolupades per a l'administració oral i per la injecció. La ciclosporina va ser introduïda al mercat per Sandoz, ara Novartis, sota la marca Sandimmune, que està disponible com càpsules de gelatina toves, com una solució oral, i com a formulació per administració intravenosa. Aquestes són totes composicions no aquoses. Una nova microemulsió, formulació administrada oralment, Neoral, està disponible com a solució i càpsules de gelatina toves (10, 25, 50 i 100 mg). Les composicions de Neoral han estat dissenyades per formar microemulsions en contacte amb aigua. A partir del 2002, una emulsió tòpica de ciclosporina per tractar la inflamació causada per la queratoconjuntivitis seca (síndrome de l'ull sec) ha estat comercialitzada amb el nom de Restasis (0.05%). Les formulacions de ciclosporina aspirada estan en desenvolupament clínic, i inclouen una solució en propilenglicol i dispersions en liposomes.

El fàrmac està també disponible com a preparació per gossos fabricada per Novartis Animal Health anomenada Atopica. Està indicada pel tractament de l'atòpia en gossos. A diferència de la forma humana del fàrmac, les dosis més baixes utilitzades en gossos indiquen que el fàrmac actua com un immunomodulator i té menys efectes secundaris que en éssers humans. Els beneficis d'utilitzar aquest producte inclouen la necessitat reduïda de teràpies concurrents per portar la malaltia sota control. També està disponible com un ungüent oftàlmic per gossos anomenat Optimmune, fabricat per Intervet, empresa que pertany al grup Merck.

Recerca

Neuroprotecció
La ciclosporina és actualment en la fase II/III (adaptativa) d'un estudi clínic a Europa per determinar la seva habilitat per millorar el dany neuronal cel·lular i les lesions per reperfusió (fase III) en traumes cerebrals. Aquest estudi està sent organitzat per NeuroVive Pharma i el Consorci Europeu de Lesions del Cervell amb la formulació de NeuroVive de ciclosporina anomenada NeuroSTAT (també anomenada CicloMulsion quan es va servir com a agent cardioprotector). Aquesta formulació utilitza una emulsió a base de lípids en comptes de cremophor i etanol. NeuroSTAT va ser recentment comparat amb Sandimmune en una fase d'estudi I i es va veure que eren bioequivalents. En aquest estudi, el NeuroSTAT no va exhibir les reaccions anafilàctiques i d'hipersensitivitat trobades en productes basats en cremophor i etanol.

La ciclosporina ha estat investigada com a possible agent neuroprotector en condicions de traumatisme cranioencefàlic, i ha estat demostrat que redueix el dany cerebral en experiments animals. La ciclosporina bloca la formació del porus de transició de permeabilitat mitocondrial, el qual causa gran part del dany associat amb lesions cerebrals i malalties neurodegeneratives. Les propietats neuroprotectores de la ciclosporina van ser descobertes per primera vegada en la primeria de la dècada de 1990 quan dos investigadors (Eskil Elmér i Hiroyuki Uchino) experimentaven amb trasplantaments cel·lulars. Un descobriment involuntari va ser que la CsA era fortament neuroprotectora quan travessa la barrera hematoencefàlica. Aquest mateix procés de destrucció mitocondrial a través de l'obertura del porus MPT està implicat en l'empitjorament de les lesions cerebrals traumàtiques. Es creu que la CsA pot limitar els danys per reperfusió en els infarts cerebrals isquèmics aguts, en especial si s'administra amb fàrmacs antioxidants com l'edavarona.

Malalties cardíaques
La ciclosporina ha estat utilitzada experimentalment per tractar la hipertròfia cardíaca (un augment del volum de les cèl·lules miocardíaques).

L'obertura inadequada del porus de transició de permeabilitat mitocondrial (MPT) es manifesta en isquèmia (restricció del flux de la sang a un teixit) i les lesions per reperfusió (el dany que ocorre després de la isquèmia quan el flux de sang retorna al teixit), després de l'infart de miocardi i quan les mutacions en l'ADN polimerasa mitocondrial ocorren. El cor intenta compensar la malaltia incrementat la concentració intracel·lular de Ca2+ per tal d'augmentar el ritme dels cicles de contractilitat -dependents. Nivells alts de Ca2+ mitocondrial causen l'obertura inadequada del MPT, circumstància que provoca una disminució de la funció cardíaca i que també origina hipertròfia cardíaca com un intent de compensar el problema.

S'ha demostrat que la ciclosporina A (CsA) disminueix la hipertròfia cardíaca afectant els miòcits cardíacs de diferents maneres. La CsA s'uneix a la ciclofilina D per blocar l'obertura de MPT, i per això disminueix l'alliberament de la proteïna citocrom C, el qual pot causar la mort programada de les cèl·lules. La CypD és una proteïna dins del MPT que actua com una porta; la unió de CsA disminueix l'obertura inadequada de MPT, fet que disminueix el Ca2+ intramitocondrial, i permet la reversió de la hipertròfia cardíaca causada per la resposta cardíaca original. Reduir l'alliberament del citocrom C causa una disminució de la mort cel·lular durant lesions i malalties. La CsA també inhibeix la ruta metabòlica de la calcineurina fosfatasa, fet que també ha estat demostrat que causa una reducció de la hipertròfia cardíaca.

Referències

Vegeu també
 Oli de ricí (additiu en Sandimmune)
 Alcohol (additiu en Sandimmune i Neoral)
 Immunosupressor

Fàrmacs oftalmològics
Medicaments essencials de l'Organització Mundial de la Salut
Fàrmacs immunomoduladors

redpajama_set_name: RedPajamaWikipedia


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		if(isset($this->session->all_userdata()['logged_in'])&&$this->session->all_userdata()['logged_in']['admin']) {
			$data['events'] = $this->event_model->get_events();
			$data['title'] = "Events";
			$this->load->view('templates/header',$data);
			$this->load->view('event/admin');
			$this->load->view('event/index',$data);
			$this->load->view('templates/footer');
		}else {
			$data['events'] = $this->event_model->get_events();
			$data['title'] = "Events";
			$this->load->view('templates/header',$data);
			$this->load->view('event/index',$data);
			$this->load->view('templates/footer');
		}

	}

	public function view($slug = NULL) 	{
		if(isset($this->session->all_userdata()['logged_in'])&&$this->session->all_userdata()['logged_in']['admin'])
		{
			$data['event_item'] = $this->event_model->get_events($slug);
			$data['title'] = "Events - ".$data['event_item']['title'];
			$this->load->view('templates/header',$data);
			$this->load->view('event/admin');
			$this->load->view('event/event',$data);
			$this->load->view('templates/footer');
		}
		elseif($this->session->userdata('logged_in'))
		{
			$data['event_item'] = $this->event_model->get_events($slug);
			$data['title'] = "Events - ".$data['event_item']['title'];
			$this->load->view('templates/header',$data);
			$this->load->view('event/event',$data);
			$this->load->view('templates/footer');
		}
		else
		{
     		//If no session, redirect to login page
			$this->load->helper(array('form'));
			$data['title'] = "login";
			$this->load->view('templates/header',$data);
			$this->load->view('login/access-denied');
			$this->load->view('templates/footer');
		}

	}

}

redpajama_set_name: RedPajamaGithub


We specialize in providing a broad range of Bamboo Carving - Pen stand-Table Decorative Items. It is known for its perfect finish, eye-catching designs and long lasting features. Bamboo Carving - Pen stand-Table Decorative Items provided by us is highly demanded in offices, institutions and residences.


The Colors Of Indian Cooking: Strawberry Cheese Cake Ice Cream Thanks To DayDreamer Desserts!
Strawberry Cheese Cake Ice Cream Thanks To DayDreamer Desserts!
Every now and then something comes along that I cannot resist and that cries out"Make me!! Immediately!" Such was the case with an amazing recipe for Strawberry Cheesecake Ice Cream via the blog Daydreamer Desserts.
The moment my husband saw that post, I knew this was going to happen, the sooner the better. The Sooner turned out to be this last Saturday evening. There couldn't have been a better time as the weather has suddenly turned warm and summery. It seems as though we've gone directly from Winter to Summer, don't pass Spring! Fresh local strawberries are everywhere. How could I resist.
I made a slight adjustment on the recipe, I used fat free sour cream which worked just fine, and the next time I try this I may go all the way and use either low-fat or fat-free Philly...just to feel virtuous mind you.
The ice cream turned out splendidly. Above you see it served up all gussied up for Saturdays' guests.
Below the way I enjoyed it the next day.
And finally, my other adjustment. I made a few extra chocolate ( I used Valrhona chocolate) covered chocolate graham crackers and turned the treat into an ice cream sandwich.
I'm definitely doing this again, and think I might try it with cherries this time around. This is what I love about these food blogs great ideas come flooding in from everywhere and just beg to be whipped up. I do have a note for Daydreamer Desserts, Alan saw your cake pops...I think I'm toast!
This ice cream sounds INCREDIBLE!
Wow what a great photo. I know it has to be awesome if your husband said so! Will diffinitely have to try this and love the fat free or low fat version ....especially since my cholestral isnt where it should be~ great job Kathy!
Beautiful! Great job ladies, this looks delicious... I need to get in on it too!
Ok, that is a CRAZY sandwich!!!
Great ice cream sandwiches. Coating them with chocolate is a great idea.
@duo dishes...I just couldn't resist! Ironically, Alan had been thinking the same thing, no wonder we're married.
yes, the next time I am for sure going to use either no fat or low..shouldn't make any difference at all...just eliminate all guilt!
I can't wait to try that buttermilk mango soup of yours!
Lovely icecream with your spin on it. Never heard of an icecream with sour cream! Looking fabulous!
it's a wonderful recipe from Daydreamer Dessert, I was so excited to make it!
it was a wonderful recipe from Daydreamer Desserts, and such fun to make!
Gosh this would be a hit at home as well!
Oh my... I love that Ice Cream Sandwitch!
I want the ice cream sandwich too!
I would eat just the ice cream, but the sandwich would be really awesome!
Who could resist this ice cream. Especially the sandwich! Yum!
Okay that ice cream sounds ridiculous, can we say YUM??? AND THEN YOU SANDWICH IT IN BETWEEN TWO CHOCOLATE COOKIES?
My younger son requested (and received) an ice cream maker for his birthday last month. Why a 7-year old needs to make his own ice cream, I don't know. But he loves strawberry ice cream, and this recipe looks amazing, especially since strawberries are gorgeous right now. I missed the Daydreamer post, so I'm glad you made the recipe. Now we have a weekend project. And I love your pic with your silver tea service. Very "passage to India".
This look amazing, I love the ice cream sandwich, perfect for strawberry season.
i wish i had had one of those at the age of seven!!lucky boy. The ice cream is amazing, such a wonderful recipe she posted. The tea service is antique english silver and is totally Passage to India!
Wowza! I love the pictures, unfortunately when you are lactose intolerant you cannot enjoy such things, but this looks delectable. As always, looking forward to the next post!


This function block will add two vectors.
Every element of input vector VX2 will be added to the appropriate element of VX1. The result will be available at VX1.
Both vectors have to have the same length; otherwise the download will be aborted with an error message.
If the two vectors differ in size, the function block will be depicted red when in run mode.


February included two Island Batik Ambassador Events. The first was the Galentines, and the second is Kennel Quilts. Last year Island Batik joined forces with the Piece for Shelter Pets which supports the Petfinder Foundation. This charity works to end the euthanasia of adoptable pets by assisting shelters and rescue groups. When disasters strike, sewing small kennel quilts for animals in need while separated from their humans is made possible by the TQPM Small Kennel Quilt Team. This month IBAs (Island Batik Ambassadors) have been challenged to make one or more kennel quilts to be donated to animal shelters either locally or send to one in immediate need.
One of the pretty 6″ strip rolls of Island Batik caught my eye and became the fabric of choice along with the dark blue Aurifil thread for my 2 kennel quilts.
I cut each of the blue strips into 2 1/2″ strips, 18 1/2″ long and sewed 2 sets of 6 strips together, alternating fabrics. The yellow fabric was cut into 1 1/2″ strips. I then slashed through one of the strips sets at a 45 degree angle and joined the pieces together with the yellow strip. I then bordered with the yellow on one side. The second quilt was done the same except that the strip was not at an angle. A paw applique (not fused) gave some more life to the quilt and added a touch of whimsey. Batting and a backing were added and sewed together and turned envelope style as it was recommended to NOT use binding. Both were quilted and there you have it – two Kennel Quilts!
Both of these quilts are being sent to the Bark and Roll Rescue Companions in Baton Rouge, Louisiana. My hope is that they add some comfort to two fur pals in need.


text:
Oil and Gas Producer Chesapeake Cuts 13 Percent of Workforce
January 30, 2018 EnergyNow Media
(Reuters) – Oil and gas producer Chesapeake Energy Corp said on Tuesday it had cut 400 jobs or about 13 percent of its workforce in its latest step to reduce costs.
The job cuts affected most functions and were mainly limited to Chesapeake's headquarters in Oklahoma City, according to an email sent by Chief Executive Doug Lawler to employees.
The move comes amid efforts by Chesapeake to raise cash in order to reduce its $9.9 billion debt load and shore up its balance sheet.
As part of those efforts, the company is selling assets worth $2 billion to $3 billion and is expected to cut its 2018 capital expenditure.
Chesapeake, which makes more than half of its revenue from selling natural gas, has been pressured by low gas prices.
Prices will likely fall further as U.S. natural gas production is forecast to increase by 6.9 billion cubic feet per day in 2018, the highest year-on-year increase on record, according to the EIA.
"(The job cuts are) not a big surprise," said Timothy Rezvan, an analyst at Mizuho Securities USA. "But the headcount does give you a lot of insight into the company's activity in 2018, which we think will be pretty low."
Shares of Chesapeake were down 5.4 percent at $3.67 on Tuesday afternoon amid a decline in oil prices.
Reporting by Yashaswini Swamynathan in Bengaluru; Editing by Sai Sachin Ravikumar
Oil Futures Lose Steam on Threat of U.S. Crude Inventory Growth
Coal Firms Plead to Courts, Trump for West Coast Export Terminals
ExxonMobil to Triple Permian Production by 2025, Expand Transportation Infrastructure


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The objective of this project is to track spectral lines and ultimately determine the strength of the lines. To track the modulation of narrow peaks visible in the gravitational wave, the computer model that stimulates an interferometer, had to be set up. Then a test panel was created to control the parameters of the components that were added to the model as a way of comparing the coherence and uncertainty. The present work on the project shows that the model outcome uncertainty is consistent with the calculated uncertainty and the front end coherence may be used as a consistent diagnostic test tool. The future plan is to look at the behaviour of signals due to environmental noise and parametric instabilities, and improve methods of tracking them.


What if my car does not meet the requirements?
What are the driver standards I have to meet?
I already drive with another company - can I drive with GoCatch too?
Provide us with the rental agreement you receive from the company so we can get you started right away!
Can I get a price estimate before I proceed with Hail & Pay?


text:
Category Archives: Pakatan Rakyat
You can run, but you cannot hide:- PM: No need for emergency session of Parliament
KUALA LUMPUR:There is no need to call for an emergency session of Parliament because the next session is soon anyway, Datuk Seri Abdullah Ahmad Badawi said.
He told this to reporters Thursday after the Umno supreme council at PWTC.
Earlier on Thursday, Datuk Seri Anwar Ibrahim had told reporters at a press conference at the PKR headquarters that he had sent a letter to the Prime Minister requesting for an emergency session of Parliament to be held by Sept 23 to deliberate on a motion of no-confidence against Abdullah's leadership.
The Dewan Rakyat is scheduled to resume its sitting on Oct 13.
To a question on whether Anwar would be arrested under the ISA, the Prime Minister said there was no suggestion from him to use the ISA on anyone. [more]
Posted in Barisan Nasional, Elections, Pakatan Rakyat, Politics
Tagged Abdullah Ahmad Badawi, Anwar Ibrahim, Emergency Session, ISA
Anwar Ibrahim Press Release On His Letter Requesting An Emergency Parliament Session
PETALING JAYA, MALAYSIA, 18 SEPTEMBER 2008
Today Pakatan Rakyat leaders have submitted a letter to the Prime Minister requesting him to call an emergency session of Parliament to deliberate a motion of censure against the leadership of YAB Dato' Seri Abdullah Ahmad Badawi no later than Tuesday 23 September 2008.
This is in accordance with Order 11(3) of the Standing Orders of Parliament and warrants an immediate response given the gravity of today's political impasse. A delay in his response would be interpreted as nothing short of a further sabotage of the democratic process and abuse of Executive Power.
The Prime Minister's haggling on the syntax of our first letter is puerile at best. The intent of our meeting as described in that letter was clearly to discuss the future course of the nation's leadership – though in deference to his position and in accordance with acceptable norms we remain considerate and polite in our approach.
I find the Prime Minister's comment about me in his press conference yesterday to be reckless and irresponsible in light of the disastrous outcome of last Friday's ISA raids.
He has conflated what is essentially an issue of democracy, freedom and the rule of law with national security. The use of the ISA to harass and detain duly elected political opponents is a grave transgression of the law and its continued use would further erode confidence in the current government and exacerbate political instability.
As the incumbent Prime Minister actively holding office and exercising all Executive powers, and as the outgoing Finance Minister, we hold him fully accountable for the current political turmoil and mismanagement of the nation's economy. His accusation that I have had an adverse impact on the nation's economy is entirely without basis.
I have met with the key fund managers in the region, representing over USD 1 trillion in assets, and on multiple occasions they were unanimously in support of comprehensive reforms in Malaysia including judicial independence, a free media, a more professional police force and anti-corruption agency, investor friendly laws and assurances on the non-interference of politicians in the governance of Bank Negara. These are policies Pakatan Rakyat has promised to implement– and initiatives that the current administration has done virtually nothing to advance since March 8th.
Leader of Opposition
De-facto leader, Keadilan
Posted in Arrest, Barisan Nasional, Censorship, ISA, Pakatan Rakyat, Politics
Tagged Abdullah Ahmad Badawi, Anwar Ibrahim, Emergency Parliament Session, ISA Raid, Vote of Censure
Anwar demands special Malaysia Parliament session
KUALA LUMPUR, Malaysia (AP) — Malaysia's opposition leader has demanded a special Parliament session to hold a vote of no confidence in the government.
Anwar Ibrahim is telling reporters Thursday that the vote needs to be held no later than Tuesday to "deliberate" on a motion of censure and no confidence in the leadership of Prime Minister Abdullah Ahmad Badawi. [more]
Parliament is currently in recess.
Posted in Barisan Nasional, Pakatan Rakyat, Politics
Tagged Abdullah Ahmad Badawi, Anwar Ibrahim, Vote of no confidence
Anwar's letter didn't mention transfer of power'
'By V.P. SUJATA, The Star
PUTRAJAYA: PKR adviser Datuk Seri Anwar Ibrahim's letter to the Prime Minister only mentioned national security, the leadership and problems on morality and politics and had not touched on the transfer of power to the Opposition.
"He had stated that his letter had mentioned the transfer of power and asked that the emergency rule is not invoked but these are not mentioned in the letter that I had received," said Datuk Seri Abdullah Ahmad Badawi. He added that Anwar was confusing the public.
Abdullah reiterated that he would not meet Anwar because his letter had not stated the issues he wanted to discuss.
He added that Anwar's lies about the country and its economic progress are a threat to national security and the country's economy.
He said Anwar had spread wrong information of the country's economic stability overseas to the extent that investors had reported that Malaysia was not a good country to invest in due to the political instability. [more]
Tagged Abdullah Ahmad Badawi, Anwar Ibrahim, Leadership
Anwar Ibrahim Moves Against Barisan-led Government
Video Clip 1: National Unity and Stability Are Critical
Video Clip 2: Datuk Zaid Ibrahim Determined to Resign
PUTRAJAYA: Datul Zaid Ibrahim has set his mind on resigning from the Cabinet, citing his disappointment with "meeting a brick wall" from his own colleagues and party members on many of his suggestions for reform.
The former de facto Law Minister also said he did not want many of the problems arising from his proposals earlier to be a burden on Prime Minister Datuk Seri Abdullah Ahmad Badawi at a time when the latter had to grapple with party conflict and other challenges.
Zaid says he is disappointed. "I don't want the PM to be beset by problems involving me and it's better for him to focus instead on other more important matters. Let me not be the problem. Although I thanked the Prime Minister for his suggestion that I go on leave instead, I am not tired. I'm just disappointed so I don't have to rest." [more]
Video Clip 3: Anwar: We have the Numbers
PETALING JAYA: Opposition Leader Datuk Seri Anwar Ibrahim has claimed that more than 31 Barisan MPs have agreed to cross over to Pakatan Rakyat.
He, however, refused to reveal the names of the 31 MPs.
Anwar told a press conference at the PKR headquarters in Petaling Jaya on Tuesday that he would give the list of the names to the Prime Minister when he meets him.
The Permatang Pauh MP also claimed that the transition to the new Government has been delayed a few days pending the meeting with Datuk Seri Abdullah Ahmad Badawi to ensure a smooth and peaceful transition.
"The numbers are increasing by the hour, but as of now, it is in excess of 31 MPs. [more]
Video Clip 4: The New Government Will Be A Reality
Video Clip 5: Badawi Refuses to Meet with Ibrahim
KEPALA BATAS: Datuk Seri Abdullah Ahmad Badawi wants Datuk Seri Anwar Ibrahim to reveal the names of the Barisan Nasional MPs the Opposition Leader claims are crossing over to Pakatan Rakyat.
"I don't think he has the names. If he does, I don't think he would wait to inform the people (of the names)," he said after giving out aid to the poor at complex Yayasan Budi Penyayang here on Tuesday.
The Prime Minister said he would not entertain Anwar's request to meet him until the list is made public.
"There is no reason for me to meet him because I don't think he has the names. He is just getting the people to focus on him and his political ploy. I do not need to see him." [more]
Posted in Barisan Nasional, Pakatan Rakyat
Tagged Anwar Ibrahim, Barisan Nasional, Pakatan Rakyat
Anwar: Sept 16 target may not be achieved
KUALA LUMPUR: Datuk Seri Anwar Ibrahim's targeted date of Sept 16 to capture the Government may not be achieved due to anticipated problems delaying the transition of power.
"After discussing with PAS and DAP, the date can be postponed even though our target was Sept 16 previously.
"However, I believe the present Government will find it difficult to quell the uproar of the rakyat," Anwar said during his speech after a solat tawarikh and hajat ceremony at his home here last night. [more]
Posted in Barisan Nasional, Pakatan Rakyat, Politics, UMNO
Tagged Anwar Ibrahim, Paratan Rakyat
Opposition chooses Anwar as new Opposition Leader
The Star,
By ELIZABETH LOOI
KUALA LUMPUR: PKR whip Azmin Ali (PKR – Gombak) submitted a letter to Dewan Rakyat Speaker Tan Sri Pandikar Amin Mulia at 4pm Wednesday that Datuk Seri Anwar Ibrahim is chosen to be the new Opposition Leader.
The letter was signed by Azmin as PKR whip, Dr Tan Seng Giaw as DAP whip and Datuk Seri Hadi Awang, president of PAS.
The Dewan would be announcing Anwar, who has just won the Permatang Pauh parliamentary seat, as the new Opposition Leader on Thursday, after he is sworn in. [more]
Posted in Pakatan Rakyat, Politics
Tagged Anwar Ibrahim, Azmin Ali, Opposition leader, Pakatan Rakyat, Pandikar Amin Mulia


@ashkyd lol, no - I did not buy any dolls on this trip! Such adult.
However, I recently discovered that there are kits to build your own reproduction Karakuri - a fact that I am trying to forget.
@AnnaGerber @ashkyd I am not going to forget this fact.
@pori @ashkyd oh my goodness I just discovered there is a detailed manual with schematics for many of these dolls published in Japan in 1796, and it has been translated into English. This must be done!


Now when I open up outlook it goes through a secure log in.
Unfortunately, I am using my own self signed cert on the server for this.
kind...and this would seem like the way to make it work.
save to my home computer to then add to the 'import' part.
anyone has experience with this stuff I would not mind a quick helping hand.
<pre wrap="">What warnings are you getting?
you generate your own cert, be sure the cert matches your FQ hostname.
can normally be overcome by importing the cert the first time.
The steps are nicely addressed in "Apache Security" (O'Reilly) by I.
Certificate Authority" pp. 93-99. They leave little to your imagination.
the actual host name. Outlook/OE are very unforgiving on that point.


text:
5 hours ago Presidential clashes: Four African countries where successors and predecessors fell out by Nii Ntreh
6 hours ago Father charged with murder after abusing three-month-old son to death by Francis Akhalbey
7 hours ago Mississippi man slapped with 12-year jail term for having phone in cell by Novieku-Babatunde Adeola
6 hours ago The first black millionaire actor who suddenly lost it all and never came back by Mildred Europa Taylor
1 week ago Mwaka Kogwa, the Tanzanian festival where men fight to settle grudges as women sing seductive songs by Ama Nunoo
7 hours ago 'It's about telling a story' – Tyler Perry denies exploiting pain of black women to make money by Francis Akhalbey
1 day ago Ivory Coast's traditional music legend Allah Thérèse dies at 70 by Novieku-Babatunde Adeola
1 day ago Top five fun facts about hugging by Novieku-Babatunde Adeola
1 day ago The little-known first female prime minister of Haiti sworn in for 100 days by Mildred Europa Taylor
1 day ago At 31, Jane Bolin became the first black female judge in the U.S. by Theodora Aidoo
1 week ago A few billionaires and millions of hungry people: These are Africa's seven most unequal nations by Nii Ntreh
1 day ago Planning a trip to Antigua? Here are six things to keep on your to-do list by Ama Nunoo
Why Are Some Africans Returning Home from the West?
June 20, 2016 at 08:30 am | Lifestyle
Mark Babatunde
Mark Babatunde is a believer in the wonders of rice and beans. Quite thin and very nervous, he likes to laugh out loud in his high pitched voice just to enrage his nice neighbors. He has a bucket list that includes jet skiing from Lagos to London. He is also a wannabe nudist, a civil engineer and the biggest fan of the Simpsons.
Muhammad Ali's Journeys Throughout Africa in Photos
Top 5 most notorious slums in Africa
Reality TV show about a polygamous man married to 4 wives makes waves in South Africa
Africa's highest paid Members of Parliament
Craig Ruttle, AP
Although the majority of Africans migrate between countries on the continent, Europe and North America continue to be highly attractive destinations, with an estimated 8.8 million documented African immigrants living between the two. Within the last couple of years, however, there has been a noticeable increase in the number of Africans buying one-way tickets to their home countries and voluntarily saying goodbye to America, Canada, or Europe.
The vast majority of Africans in the west are either working or studying; many of them enjoy a satisfactory quality of life. They are indeed an important economic force for Africa: in 2012 alone, remittances from the African diaspora were put at an estimated $60.4 billion.
Many of them made the journey abroad against all odds and can tell gripping narratives of the challenges they surmounted along the way: raising enough cash to proceed with the journey; the "soap opera" of getting on a waiting list to process an international passport and travel visa; and finally, the nervous prayers that they have enough charm and luck to sway the foreign embassy officials even after meeting basic visa requirements.
African Migrants Continue to Die Crossing Mediterranean
Money Sent by African Diasporans to Continent Improves Livelihoods, Fuels Economies
Diaspora Women's Network (DAWN) President Speaks on Potential Wins of U.S.-Africa Summit
The Power and influence of Diaspora Africans
After going through so much trouble to get there, it's natural to wonder why some Africans would leave the higher standard of living in the Diaspora and voluntarily come home, but there are several reasons for this trend.
Some returnees point to the opportunities available in the newly emerging economies of several African nations. The education, training, and experience they have acquired in their time abroad makes these returnees confident that they can contribute meaningfully to their country's development. They come home with a head start on the latest frontiers in industry and business. For example, many African IT professionals returned home during the explosion of mobile telephony across the continent.
Others cite patriotism as the reason for their return. Like the previous group, many of these returnees are skilled professionals – surgeons, university professors, etc. – with the necessary skills to impact the lives of their community almost singlehandedly. Many of them have gone on to do social work or join the civil service.
A few confess that they just couldn't help feeling nostalgic about their home country, friends, family, and loved ones they had left behind. They simply woke up one day and decided they had had enough, gathered whatever they could ship and made the journey back home. They may have never really enjoyed their immigrant status or had no intention to move away forever, considering their time abroad as a period spent doing some migrant work before moving back home to retire or start a better life with the resources they gained in the west.
While many returnees go on to become eminent members and strong contributors within their home countries, re-integrating with the community back home is not always smooth sailing. Some complain about the undue expectations from people back home who believe they must have returned with lots of money to throw around. Others simply cannot cope with the near system failure of government institutions in many African countries after spending several years in a developed country. A few find it so difficult to fit in that they eventually decide to migrate back to the west once again.
Top five fun facts about hugging
In a period campaign, model Kenny Ethan Jones tells of pain of menstruating as a trans man
Tanzania superstar Diamond and Eto'o team up to establish soccer academy
Prince Harry and Meghan Markle 'quit' royal family – Palace 'disappointed', social media reacts
How this popular black evangelist colluded with FBI to destroy MLK in the 1960sby Mildred Europa Taylor
Burna Boy makes Michelle Obama's workout playlist for 2020by Novieku-Babatunde Adeola
Killed over a bottle of orange juice, this 15-year-old helped spark the 1992 L.A. riots


text:
AlloSource helps NASA in antimicrobial study on International Space Station
Tuesday December 11, 2018 0 comments Tags: Centennial, AlloSource, NASA, ISS, Peter Stevens, NASA JPL
CENTENNIAL -- AlloSource, dedicated to advancing the science and use of transplantable allogeneic cells and tissue, announced it served on a contributing science team to NASA's Jet Propulsion Laboratory's (JPL) scientific study on further antimicrobial survivability on the International Space Station (ISS).
The science and results were highlighted in the recently published article titled "Multi-drug resistant Enterobacter bugandensis species isolated from the International Space Station and comparative genomic analyses with human pathogenic strains" in BMC Microbiology.
As a follow-up to a previous study, which used molecular methods to characterize genes from ISS environmental samples, the current study focused specifically on five ISS isolated Enterobacter bugandesis species and their antimicrobial survivability. Bugandesis is a common intestinal organism; the strains found on the ISS do not pose a risk to human health. The study categorized a pattern of antimicrobial resistance genes associated with all five strains that differed from similar terrestrial strains.
Because microorganisms will always be present in human-based spaceflight, these microbial studies of the ISS are critical for the development of mitigation procedures on future long-duration missions, AlloSource said.
"Working with the NASA/JPL team is an amazing experience and AlloSource's scientists are grateful for the opportunity to support the strides in understanding the amplified health challenges of living in space," said Peter Stevens, AlloSource's chief new ventures officer.
"While AlloSource's day-to-day work with human cells and tissue takes place on earth, we look forward to continued collaboration with JPL rooted in science and health."
AlloSource said its scientists supported the study by providing the initial identification of antibiotic resistance, which was confirmed at JPL by genomic sequencing.
In addition to research collaboration on ISS microbiology, AlloSource continues to leverage technologies developed by NASA and JPL for assembly and launch operations to advance microbial research in tissue processing.


There are no murders to report tonight but there were three shootings over the weekend. Forty-seven year old Honduran national Miguel Marcia remains bedridden inside the recovery ward of the K.H.M.H. after being shot during a robbery attempt. Marcia, a local vendor, was on his way to catch a boat near the foot of the Swing Bridge on Saturday morning when he was attacked by a lone gunman as he walked along King Street. Despite his screams for help Marcia, was fired upon several times by his attacker hitting him in the lower abdomen. Marcia recounted the ordeal from his hospital bed this afternoon.
Marcia is listed in a stable condition at the Karl Heusner Memorial Hospital.
Mr, Marcia, I wish you a speedy recovery. This idiot needs to be caught, it is just by pure luck that we are not reading about another murder.
1)Children shot to death in the safety of their homes, several teenagers, students, and mothers slain, with no arrest or proper investigation being done.
2)Politicians and respectable members of society praising an infamous, recently deceased Gang leader who's responsible for many of the carnage in this crime-rigged City.
3)Government who continuosly downplay a serious crime wave, while over 100 people are being murdered annually for the past 5 years.
4)One Immigration scandals and Drug bust after another, without any meaningful arrest or conviction of the 'Bigwigs' responsible.
5)PM who turns the blind eye to his Ministers' shady deals or questionable characters.
6)Missing Grenades from the soon to be defunct BATSUB, still unaccounted for, presumably in the hands of Gangbangers.
7)Rogue police officers, still in uniform, after kangaroo hearings exonerated them.
8)Police Officer shot and maimed a hardworking husband and father, while the BPD encouraged this maimed man to sue them, if he needs money for groceries.
9)Politicians, their families and friends, continue living extravagant lifestyles, while John Q Public's either starving or footing the bill.
10)High fuel prices, high cost of living, high taxes, high unemployment rate, low minimum wage and a government that has failed to create a single job.
I am not surprised at how many times this hard working man was accosted by those animals wanting to take what obviously does not belong to them.
Vendors need to arm themselves with hand guns to protect themselves from these savages. How many more will be shot, or killed by those animals out there.
Vendors should unite and lookout for each other….these idiots try that move in BMP and they will be the statistic….!@#$%^& Farasites!
Third Party Advocate has hit the nail with the hammer! Now what? Belezeans sit back and watch this country destroyed by a few, or actually do someting to prevent that?
We'll just have to wait and see. My prediction for the next elections are a landslide victory for PUP, on account of the voters voting for the highest bidder, and they will find more than enough cash to sway votes on the day. If not, party hired Gangstas will be out anyway, to 'persuade' voters…….. Might be a lot safer to stay at home!!!!
What happen gramps, scared of reading? It won't bite, just try it mein.
third party adv…basically wrapped it up in a coconut shell. This victim was robbed what five times, he's very lucky to be alive and brave to scream for help. too bad the attacker did trip and shoot his own self in the stomach…see how he like it. If you don't give these thieves what they want they try kill you, whether they carrying gun/knife or machete.
Why you people taking about PUP and UDP both party have been in the goverment and the crime still happen and its only going to get worst guns are easier to come by drugs the flow more and kids have no discipline and all the parent keep crying bout the goverment when deh bad pickney get arrested . back in the day you had bloods and crip and lot of shooting use to happen then too but the difference is that police had more control and nobody mi the complain . maybe if we have more police unit like dragon when broaster and jeffery and hendeson mi run around belize maybe thing might change or even curfew but i guarantee that if that was to happen you going to hear the public start crying bout deh rights . something have to give if you want to see results . As for me i have no sympathy for any criminal out there that get abuse or shot by police or any law abiding citizen Hell when Tabalda use to run tactical the street was safe maybe that is what we need .
My above comment is a small summary of recent and past occurrences in our Jewel. I realize it's a bit too wordy, especially for those who don't like to read. In Belize we tend to forgive too quickly and forget too easily, hence the crimes become more heinous, and Politicians become less productive. We have elected and selected Politicians who were given the honor of running, not wrecking our precious Jewel. DEMAND SOLUTIONS AND RESULTS FROM THEM!


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Would you like for your student to study classic literature but you don't have a lot of time or money to pour into a year long class? Consider our à La Carte Classics. Angela will work with your student one-on-one, guiding them through the selection of your choice. Sessions last only four to five weeks (depending on the book) and include a reading schedule, weekly discussion questions, and a final writing assignment geared to your individual student's needs. Sessions begin when you are ready -- no need to wait for a class to open and since sessions are one-on-one, classes never fill.
It's an affordable option that brings classic literature directly to your child!
Animal Farm: A Fairy Story
George Orwell's timeless and timely allegorical novel—a scathing satire on a downtrodden society's blind march towards totalitarianism. -- Amazon
A daring wager by the eccentric and mysterious Englishman Philes Fogg that he can circle the globe in just eighty days initiates this marvelous travelogue and exciting suspense story by French author Jules Verne. -- Amazon
Madeleine L'Engle's Newbery Medal award winning book is the story of the adventures in space and time of Meg, Charles Wallace, and Calvin O'Keefe (athlete, student, and one of the most popular boys in high school). -- Amazon
Regarded as one of the greatest dramas ever written, Cyrano de Bergerac is Edmond Rostand's story of the silver-tongued soldier whose unfortunate looks drive him to woo his love by speaking for his handsome but dull-witted rival. -- Amazon
Mary Shelley's Frankenstein, a gripping story about the ethics of creation and the consequences of trauma, is one of the most influential Gothic novels in British literature. It is as relevant today as it is haunting. -- Amazon
Island of the Blue Dolphins
The Newberry Medal-winning story by Scott O'Dell of a 12-year old girl who lives alone on a Pacific island after she leaps from a rescue ship. -- Amazon
My Ántonia
My Ántonia evokes the Nebraska prairie life of Willa Cather's childhood, and commemorates the spirit and courage of immigrant pioneers in America. -- Amazon
As the German troops begin their campaign to "relocate" all the Jews of Denmark, Annemarie Johansen's family takes in Annemarie's best friend, Ellen Rosen, and conceals her as part of the family (by Lois Lowry). -- Amazon
The Call of the Wild, considered by many London's greatest novel, is a gripping tale of a heroic dog that, thrust into the brutal life of the Alaska Gold Rush, ultimately faces a choice between living in man's world and returning to nature.
-- Amazon
The Catcher in the Rye
J.D. Salinger's classic novel of teenage angst and rebellion was first published in 1951. The novel was included on Time's 2005 list of the 100 best English-language novels written since 1923. It was named by Modern Library and its readers as one of the 100 best English-language novels of the 20th century. -- Amazon
Chaim Potok's now-classic story of two fathers and two sons and the pressures on all of them to pursue the religion they share in the way that is best suited to each. -- Amazon
Elizabeth George Speare won the 1959 Newbery Medal for this portrayal of a heroine whom readers will admire for her unwavering sense of truth as well as her infinite capacity to love. -- Amazon
Harper Lee's Pulitzer prize-winning masterwork of honor and injustice in the deep south—and the heroism of one man in the face of blind and violent hatred. -- Amazon
Some selections may not be appropriate for all students or for all ages. Parent assumes responsibility for novel selection. A grade for the course will be issued upon request at no extra charge.
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Red Carpet Style: Kate's bound to show off her new, svelte figure in a Balmain LBD.
Most Likely To: Give Gwyneth Paltrow a run for her money in the crying stakes.
Red Carpet Style: Old-school Hollywood has been Brad's inspiration on the red carpet recently so we can expect a bespoke suit, woollen scarf and, of course, his moustache on Oscars night.
Most Likely To: Be star-struck by his fellow nominees. "When I started out, my gods, so to speak, were Gary Oldman, Sean Penn and Mickey Rourke, so it's a real honour for me to be sitting at the same table," he said.
Red Carpet Style: Something black and/or white, minimalist and probably Versace.
Red Carpet Style: Some describe Mickey's style as bohemian; others say it's just a bit of a mess. He's a fan of velvet lapels – let's hope he pulls it together for his big night!
Red Carpet Style: Petite Pen likes to play it safe with classic, sculpted dresses and a neat up 'do.
Most Likely To: Come without a date. She's famously protective of her relationship with co-star Javier Bardem.
Most Likely To: Get bored during the ceremony; this is Meryl's 15th Oscar nomination after all.
Red Carpet Style: She might wear a nun's habit in Doubt but when it comes to the red carpet, Amy Adams likes to show off her milky skin in black or flesh-coloured tones.
Red Carpet Style: Marisa has impressed us with a number of bold, red carpet choices, but we reckon the actress will opt for a voluminous, Giambattista Valli creation on Oscars night.
Most Likely To: Trip on her way to the stage. The starlet lost her footing when she won Best Supporting Actress in 1993.
Red Carpet Style: Debonair RDJ is a bit partial to three-quarter-length jackets, but then again he may surprise us – at the Golden Globes, the actor turned up in a pair of Converse trainers.
Red Carpet Style: There's been a noticeable difference since Rachel Zoe took over Anne's styling. Expect bright colours, statement pieces and intricate detailing from the first-time nominee.
Most Likely To: Want a rival to win. Anne is a massive Meryl Streep fan.


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The total amount of all your purchases incurred since your most recent Statement. It does not include interest charges or fees.
* Depending on your Card, this may not include disputed items, amounts in suspense, returned purchases or loan balances.
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The Mayor Transport Police + Fire Devolution
Mayor's column, first ever Sunday edition of Manchester Evening News
Environment Transport
Greater Manchester tells Government: "Play fair on clean air"
Homelessness Health Housing
"Our groundbreaking A Bed Every Night scheme will now be extended for a year to July 2020"
Homelessness Housing
A Bed Every Night, Greater Manchester's rough sleeping strategy, secures significant NHS funding
Health Ageing
Mayor warns PM hopefuls: tax cuts for rich cements social care underfunding & betrays WW2 generation
Earlier this month the Manchester Evening News (MEN) launched its first ever Sunday edition. The Mayor was invited to contribute an opinion piece, which is reproduced below.
WHEN I speak to residents across our 10 boroughs people call for two things more than anything else: more police and better buses.
I've no doubt that these are priorities for MEN readers as well.
So this year I am making sure that the Mayoral budget matches the people's priorities.
Our police do an incredible job in very tough circumstances but just last year our Chief Constable warned that warned fresh budget cuts could take officer numbers back to levels last seen in the 1970s.
This is just not acceptable.
The Government should be making sure our public services are properly funded, but they are not. The truth is that while the Government boasts of tax cuts, this is a sleight of hand; at the same time they have slashed the national budgets that fund our vital public services.
Ultimately, the reason we are having to look at increasing the police element of the council tax is simple – the Government has once again shunted the financial burden of policing onto local taxpayers.
Raising council tax is never an easy decision. I know any increase hits the budgets of hard-pressed families across our city-region.
But £24 extra this year will allow us to bolster Greater Manchester Police by recruiting 320 additional police officers and tackle both serious and violent crime. Some of these new officers will be used to police our transport system – Metrolink and buses – to tackle crime and anti-social behaviour.
Westminster is forcing local authorities to put up council tax to keep vital local services going.
I am also determined to fix another thing that Government has broken – our bus network.
More than three quarters of public transport journeys in Greater Manchester are made by bus. While it rarely gets the attention it deserves nationally, buses are the backbone of our transport network.
But in Greater Manchester, bus use is declining amongst the young and across the population and there are now around 32 million fewer journeys by bus than 10 years ago.
That is the simple reason why so many routes are being cut. It also raises the risk of rising fares because of dwindling passenger numbers.
I am asking for a £7 increase for this coming year - equivalent to less than 20p per week for the average Greater Manchester household - and this money will be dedicated solely to turning round our bus network.
We simply won't fix our bus network until we get more passengers using it. That means starting with young people.
Our plans for an Opportunity Pass for 16 to 18-year-olds, giving young people free bus travel, will get them back on buses- which will help shore up bus services currently at risk.
Our Opportunity Pass won't just benefit young people and their families - it will benefit everyone by helping build a better bus system.
At a time of national uncertainty, Greater Manchester is moving forward and taking the decisions needed to keep us safe and keep up moving. This Budget delivers that.
Article Published: 15/02/2019 10:27 AM


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Disney+ Launches in Latin America
Following pre-launch activities earlier this month, Disney+ is now available in 10 countries throughout South America — little more than a year after Disney bowed its branded SVOD platform in the United States. Countries include Argentina, Brazil, Chile, Colombia, Peru, Mexico, Costa Rica, Ecuador, Panama and Uruguay, with service costing $5.99 monthly or $59.99 per year.
With more than 73 million subscribers through the most-recent fiscal quarter, Disney eyes Latin America as the platform's next big growth sector after India.
Research firm eMarketer says Latin America has become a prime focus for SVOD services largely because of its improving digital infrastructure and the growing need for indoor entertainment throughout the coronavirus pandemic. A May 2020 survey from McKinsey & Company revealed that nearly 64% of adults in Mexico reported spending more time watching video content during the pandemic than they did normally.
"We now expect the number of subscription OTT video viewers in Latin America to grow by 27.5% this year to 117.2 million," analyst Matteo Ceurvels wrote in a post. "That's a roughly 16-percentage-point increase from the 11.6% growth we previously anticipated in our September 2019 forecast."
Ceurvels said regional SVOD platforms Claro video and Globoplay have seen subscriber growth, but lack the fiscal scale of Netflix, Amazon Prime Video (launched in 2016) and Disney+ to compete more effectively.
"What's more, HBO Max and Hulu will be rolling out in these markets in 2021," he wrote.
Amazon, Lionsgate Ink Latin America Distribution Deal
Amazon and Lionsgate Feb. 27 announced an exclusive multiyear agreement under which Lionsgate will make available select movies to Prime Video members in Mexico, Brazil and the rest of Latin America. The agreement includes Lionsgate and Summit Entertainment movies to stream on Prime…
Europa+ SVOD Service Launches in Latin America
A new subscription streaming video service based in Atlanta has launched operations in Latin America. Dubbed Europa+ (Europa Más), the $5.99 monthly service features content from the U.K., Germany, France and Nordics. Designed for European ex-pats, Latin Americans of European…
Disney Licensing Movies, TV Shows to Amazon Prime Video in Latin America
Disney is set to release a branded subscription streaming video service on Nov. 12 featuring branded movies, TV shows and original content. In the interim, Disney is reportedly licensing select movies and TV shows to Amazon Prime Video in Latin…
Sony Shuttering Crackle Latin America
Sony Pictures Television is shutting down Crackle Latin America, the subscription streaming video service launched in 2016. The service with 400,000 subscribers – across 17 countries – will cease operations on April 30. Sony has operated Crackle as an ad-supported…


DQ9 Walkthrough - Western Coffinwell walkthrough, hints and guide.
Leave Western Stornway by the northeast exit and cross a bridge to reach Western Coffinwell.
Head north to the town of Coffinwell.
There is an island only accessible by ship to the west of Western Coffinwell.
To reach this island, first Zoom to Stornway, then go north to find your ship and get on board. Then follow the river north to reach this island.
There is nothing on this island, but a building with a cow inside it.
After you come into possession of Starflight Express, land at the north bit of Western Coffinwell. You can see a very high tower in this area. This portion of Western Coffinwell had been unaccessible on foot.


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New Zealand International Film Festival 2016
2016 • 80 minutes • 10 ratings • 3 reviews
Directed by Sam Hamilton
Starring Calvert DeForest, Brother Theodore, Irene Cara, Veronica Hamel and Tony Azito
Shot on 16mm celluloid across parts of New Zealand and Samoa, interdisciplinary artist Sam Hamilton's ten-part experimental magnum opus makes thought-provoking connections between life on Earth and the cosmos, and, ultimately, art and science. Structured around the ten most significant celestial bodies of the Milky Way, Apple Pie's inquiry begins with the furthest point in our solar system, Pluto, as a lens back towards our home planet and the 'mechanisms by which certain aspects of scientific knowledge are digested, appropriated and subsequently manifest within the general human complex'. Christopher Francis Schiel's dry, functional narration brings a network of ideas about our existence into focus, while Hamilton's visual tableaux, as an extension of his multifaceted practice, veer imaginatively between psychedelic imagery and performance art.
★★★★★ review by Josiah Morgan on Letterboxd
NZIFF 2016//Film #6
Don't even know how to write about this so forgive me for the average review. The most important experimental work of the century so far? Maybe - frustrating that I may not get to see this ever again (at the very least not for the next few years) because Hamilton not only nails his own performance-based style but also manages to expand on traditional flicker-film orientations, whilst developing the medium of landscape filmmaking tenfold. I don't know how to sell this film to anyone - it's a journey across the universe via the avant-garde.... and it's one of the best things I've ever seen.
★★★★ review by Erin Harrington on Letterboxd
A stoned philosophy undergrad, a Guy Maddin film and Philip Glass's 1970s Sesame Street circles meet in a bar in Samoa for an existential threesome. I was worried during the opening voiceover that it was going to go down the unrepentant self-indulgent route, but it's very sweet, a little silly and quite endearing with a great look and a killer soundtrack and by the end I was quite won over. During the credits the old guy sitting in front of me turned around and said 'well that's the queerest film I've ever seen.' Your mileage may vary.
Tweets by @nzff


The Oasi Garden Rooms are located on the ground floor of the new exclusive Spazio Oasi complex with cool, elegant furnishings in shades of white and beige. With their large windows, the rooms blend into their lush Mediterranean gardens which feature with an outdoor sitting area. The Oasi Swimming Pool is just few steps away from the Garden Oasi rooms, making it ideal for couples seeking privacy and intimacy in a charming environment.


The baby poll is now closed. Thanks for participating. Results to be announced whenever Baby J makes his appearance!
(personally I'm hoping for sooner rather than later!).
In other news, we had one last ultrasound today...Baby J is definitely a boy. The confirmation is nice since our boy/girl determination was made by one technician...19 weeks ago. So a second opinion is always a good thing. It also means that we're not scrambling to think of lovely girl names on the fly.
Things were hopping at GH-Central; lots o people having babies today! So far we are loving both the midwifery and nursing staff there. They didn't even blink when the girl next to me had her water break. Whoosh!!! Time to get that lass into a delivery room!
I'd equate more to having a bowel movement. Gross but true. Push like you need to poo.


Curator, American Art Job viewed 463 times.
The James A. Michener Art Museum, a private non-profit organization with in Doylestown, PA seeks a full-time Curator of American Art.
In collaboration with the Executive Director and other members of the curatorial department, the Curator is responsible for curatorial activity including assisting in the management and development of the museum's collection; organizing exhibition projects; pursuing acquisitions; and producing scholarly and written materials for a wide range of audiences. Work will focus on interdisciplinary and collaborative projects with museum staff, community organizations, and peer museums, and promoting research and scholarship on American art, with a focus on the artists of Bucks County and the greater Delaware Valley Region.
In conjunction with the Executive Director develop/identify temporary exhibitions and permanent collection displays that will engage existing and target audiences.
Act as coordinating curator for package exhibitions.
Integrate collection research and educational mission into gallery didactics, lectures, and public programs for internal and external audiences.
Research, write, and present, in written and oral form, information on permanent and temporary exhibitions for local, regional, and national audiences.
Play lead role in development and achievement of curatorial budget and multi-year exhibition calendar.
Lead curatorial staff in the preparation and management of the exhibition schedule, permanent collection displays, and publications.
Manage curatorial department staff including registration, library and archives, and art preparation.
Liaise with the Collections Committee of the Board of Trustees to maintain the mission of the collection.
Represent the Museum through media/public interviews.
Participate in the development of grants and fundraising for exhibitions and the collection.
Research acquisitions for the permanent collection.
Specialization in American Art; excellent working relationships with colleagues in the field, including artists, collectors, gallerists, critics, and scholars.
Ability to write and conduct research at an advanced level and maintain precise and careful records.
Knowledge of the methods, techniques, and procedures involved in the interpretation and exhibition of art for a diverse audience.
Excellent leadership, problem solving, budget management, planning, and organization skills, with the ability to manage multiple projects and responsibilities.
Strong written and oral communication skills and public speaking abilities, as well as teaching and presentation skills.
Ability to establish, maintain, and foster positive and harmonious working relationships with staff, visitors, volunteers, artists, collectors, donors, lenders, and professional colleagues, and other members of the museum community.
Willingness to work flexible hours including mornings, evenings, and weekends.
Work collaboratively with other departments to ensure Museum goals and objectives are met.
Advanced degree (PhD preferred) in art history, with a principal focus on American art but interests that reach across countries and chronologies.
Minimum of seven (7) years of experience in a museum or academic institution.
Experience in exhibition development, publication development, and collection care with knowledge of and commitment to professional museum standards.
Strong record of publications in the field required.
Strong interpersonal skills, particularly when working with donors and the public.
*This position description is designed to accurately reflect job duties; however, it may not be all-inclusive and other job related duties may be required.


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After a thorough analysis and research of your health and physical condition and also of your needs, we'll be able to compose a detailed, daily programme of exercises with the number of hours to spend on required body areas.
With this plan you'll be able to do your exercises effectively even without a personal trainer's supervision.
Below is some of the topics we can discuss when advising you on nutritional plans. Following a plan will ultimately compliment your 1:1 Personal Training goals.
Our 1:1 nutrition coaching is an incredibly effective tool to encourage healthier lifestyle choices.
We'll give you the help and advice you need to identify, enact and sustain improvements in your life.
Our tailored food plans and exercise programmes will help you achieve your goals.


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Cheer up! There's still some football to watch! Bye Week OPEN THREAD
The Rebels aren't playing today, but that doesn't mean there isn't football to watch.
Share All sharing options for: Cheer up! There's still some football to watch! Bye Week OPEN THREAD
Kevin Jairaj-US PRESSWIRE
The Grove sits empty, your living room is much less lively, and your local sports bar is full of fans of teams you don't like. The Ole Miss Rebels are not playing football this weekend, and that makes us and everything involved in our sports loving lives sad.
But there's still football to be had, and football that's eventually important to us Rebel fans! So cheer up, watch, and join us in the comments thread below if you feel so inclined. A list of who is playing today and how you can watch is right here:
Time Road Home TV Streaming
Noon ET Eastern Michigan No. 11 Michigan State Big Ten Network btn2go.com
Noon ET Troy No. 13 Georgia SEC Network ESPN3.com
Noon ET Bowling Green No. 19 Wisconsin ESPN2 ESPN3.com
Noon ET Western Illinois Northwestern ESPNews ESPN3.com
Noon ET Iowa Pittsburgh ESPNU ESPN3.com
Noon ET Southern Illinois Purdue Big Ten Network btn2go.com
Noon ET Old Dominion Rice FSN, ROOT foxsports.com/foxsportsgo/
Noon ET Georgia Tech Virginia Tech ESPN ESPN3.com
12:30 p.m. ET Tulane Duke RSN, ROOT
12:30 p.m. ET Maryland Syracuse ACC Network
12:30 p.m. ET James Madison Villanova CSN
1 p.m. ET Maine Boston College ESPN3.com
1 p.m. ET Delaware State Temple ESPN3.com
1 p.m. ET Eastern Kentucky UT-Martin ESPN3.com
2 p.m. ET Marshall Akron ESPN3.com
2 p.m. ET Hawaii Colorado Pac-12 Network pac-12.com/live
3 p.m. ET VMI Samford ESPN3.com
3 p.m. ET Eastern Washington Montana State ROOT
3:30 p.m. ET No. 6 Texas A&M SMU ABC/ESPN2 ESPN3.com
3:30 p.m. ET Virginia No. 21 BYU ESPN ESPN3.com
3:30 p.m. ET Florida No. 3 Alabama CBS cbssports.com
3:30 p.m. ET Norfolk State Buffalo ESPN3.com
3:30 p.m. ET North Carolina East Carolina ESPNU ESPN3.com
3:30 p.m. ET Louisville FIU FS1 foxsports.com/foxsportsgo/
3:30 p.m. ET Central Michigan Kansas FSN, SunSports foxsports.com/foxsportsgo/
3:30 p.m. ET Utah Michigan ABC/ESPN2 ESPN3.com
3:30 p.m. ET Rutgers Navy CBSSN
3:30 p.m. ET Nicholls State North Texas Sinclair
3:30 p.m. ET Army Wake Forest ESPN3.com
3:30 p.m. ET Howard Morgan State ESPN3.com
4 p.m. ET Texas State Illinois ESPNews ESPN3.com
4 p.m. ET San Jose State Minnesota Big Ten Network btn2go.com
4 p.m. ET Indiana No. 18 Missouri SEC Network ESPN3.com
4 p.m. ET Massachusetts Penn State Big Ten Network btn2go.com
4 p.m. ET Florida Atlantic Wyoming Mountain West Network themw.com/#!/watch-live
4 p.m. ET New Hampshire Richmond CSN
4 p.m. ET Incarnate Word Abilene Christian ESPN3.com
6 p.m. ET Presbyterian NC State ESPN3.com
6 p.m. ET Bethune-Cookman UCF ESPN3.com
6 p.m. ET Georgia State Washington Pac-12 Network pac-12.com/live
6 p.m. ET Ave Maria Mercer ESPN3.com
7 p.m. ET Miss State 8 LSU ESPN ESPN3.com
7 p.m. ET Northern Illinois Arkansas ESPNU ESPN3.com
7 p.m. ET Utah State Arkansas State ESPN3.com
7 p.m. ET Miami (Ohio) Cincinnati CBSSN
7 p.m. ET Northwestern State Louisiana Tech
7 p.m. ET Middle Tennessee State Memphis ESPN3.com
7 p.m. ET Idaho Ohio ESPN3.com
7 p.m. ET Appalachian State Southern Miss American Sports Network
7 p.m. ET Ball State Toledo ESPN3.com
7 p.m. ET Murray State Western Michigan ESPN3.com
7 p.m. ET Bryant Liberty ESPN3.com
7:30 p.m. ET Georgia Southern South Alabama ESPN3.com
7:30 p.m. ET No. 14 South Carolina Vanderbilt SEC Network ESPN3.com
7:30 p.m. ET No. 4 Oklahoma West Virginia FOX foxsports.com/foxsportsgo/
8 p.m. ET No. 22 Clemson No. 1 Florida State ABC ESPN3.com
8 p.m. ET UNLV Houston ESPN3.com
8 p.m. ET Miami No. 24 Nebraska ESPN2 ESPN3.com
8 p.m. ET New Mexico New Mexico State ESPN3.com
10 p.m. ET California Arizona Pac-12 Network pac-12.com/live
10 p.m. ET Southern Utah Fresno State Mountain West Network themw.com/#!/watch-live
10:30 p.m. ET Louisiana Boise State CBSSN
10:30 p.m. ET San Diego State Oregon State FS1 foxsports.com/foxsportsgo/
10:30 p.m. ET No. 2 Oregon Washington State ESPN ESPN3.com


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German Herrera follow Mexican, born 1957
Lives in San Rafael, California, United States
"...the rationale is to work with what happens". Frederick Sommer
The body of work these images belong to, emerged after a period of 10 years of not exercising any form of image making. The collage form has been used as a response to the need of addressing an internal reality, previously inaccessible and much more complex than the material available before.
I believe that the more individual the search is, the more universal it becomes.
Germán Herrera
Blanca Berlin Galeria, Madrid, Spain
De Santos Gallery, Houston, TX, United States
SFMOMA Artists Gallery, San Francisco, CA, United States
Smith Andersen North, San Anselmo, CA, United States
Toomey-Tourell Gallery, San Francisco, CA, United States
There is no message to decode. If anything, the transmission of an emotion may take place.
Process Statement
I photograph what feels compelling, attractive, disgusting -the images are correspondences... nods to these connections. Dreams, beliefs, fears, intuition and aesthetics nurse the approach as I move on to amalgamating the image; in the same emotionally conscious and undirected way.
They are not the product of an idea or an association of ideas, but possibly a diary of maps. The biggest challenge as they are constructed is to stay away from thinking, instead concentrating on the emotions that arise.
Germán Herrera was born in Mexico City in 1957. The first of five siblings in a family of psychologists, he inherited his love for photography from his maternal grandfather and an interest in music from his father and maternal grandmother. In 1978 he traveled to California to study photography, where he became interested in Afro Cuban drumming. In 1980 Herrera returned to Mexico and devoted himself to music and commercial photography. In the late 1980s he traveled to Cuba where he produced his last body of documentary work, then stopped working with the camera for eleven years. His interest in spirituality took him to India where he spent six months. This led to a process of self-investigation, including two years of training in Core Energetics (a Neo-Reichian mode of psychotherapy), which contributed fundamental information to his current form of image making. In 2001 Herrera returned to photography, simultaneously discovering the complex potential of the digital environment as a creative tool.
Herrera was recipient of an Artist Residency at the De Young Museum in San Francisco in 2006. He is also the recipient of two Marin Council grants and has been nominated for the Eureka Awards, granted by the Fleischhacker Foundation.
He is presently working on the publication of a monograph with 100 images and a text by Elizabeth Ferrer, curator and writer of the Aperture book Lola Alvarez Bravo and co-editor of the landmark New York Museum of Modern Art publication Latin American Artists of the 20th Century.
His work has been exhibited in North and South America as well as in Europe, and is part of the permanent collections of:
Bolinas Museum, California.
Green Library at Stanford University, Palo Alto, California.
Museum of Fine Arts in Houston, Texas.
Harry Ransom Center, University of Texas, Austin, Texas.
Museum of Photographic Arts of San Diego, California.
Portland Art Museum, Oregon.
Zoellner Arts Center, Lehigh University, Bethlehem, Pennsylvania, amongst others.
He lives in San Rafael, California, with his wife Nayana and two cats.
2003 Nueva Luz
Zone Zero Portfolios
germanherrera.com
silenthead.wordpress.com/


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Francesco Intinacelli (born 12 November 2001) is an Italian footballer. He plays for Serie D club Casale.

Club career
He made his Serie B debut for Ascoli on 17 June 2020 in a game against Cremonese.

On 5 October 2020 he joined Serie C club Fermana on loan. He only made one substitute appearance for Fermana in the first half of the season, and on 8 January 2021 his loan was terminated and he returned to Ascoli, where he was assigned to the Under-19 squad.

On 27 August 2021 he extended his contract for Ascoli until 2023; on the same day he went to Montevarchi on loan.

On 9 September 2022, Intinacelli moved to Casale in Serie D.

Club statistics

Club

References

External links

2001 births
Living people
Sportspeople from Chieti
Italian footballers
Association football forwards
Serie B players
Serie C players
Ascoli Calcio 1898 F.C. players
Fermana F.C. players
Montevarchi Calcio Aquila 1902 players
Casale F.B.C. players
Footballers from Abruzzo
21st-century Italian people


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Q: Spectral radius of discrete Laplacian We discretize the domain $\Omega = [0,1]^2$ with the step size $\Delta x = \frac{1}{n-1}$. Then, for the largest eigenvalue of the discrete Laplacian it holds
$$\lambda_{\max}(-\Delta)\leq 8(n-1)^2.$$
I tried to find a proof for that, but was not successful. Is there an explanation? Thanks!

Edit: the boundary condition for a solution $m$ is given by $\nu \cdot m = 0$ on $\partial \Omega$, where $\nu$ is the normal field of $\Omega$.

A: If you are using standard finite differences, you matrix will be "penta-diagonal" and Gerschgorin's theorem can give you an estimate of the spectral radius. Using the most populated rows, you can see that any eigenvalue $\lambda$ satisfies
$$
\left|\lambda + \frac{4}{h^2}\right|\leq \frac{4}{h^2}.
$$
So, you can conclude that $|\lambda| \leq 8(n-1)^2$ (I'm assuming the solution vanishes at the boundary).

redpajama_set_name: RedPajamaStackExchange


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