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MP backs Radio Exe
Friday, March 20th, 2020 11:32am
By Paul Nero
Jupp is a presenter again!
A recently elected MP is back on air as a presenter for the first time since becoming the honourable member for East Devon!
Simon Jupp (Conservative) is a former broadcaster who previously covered shows on Radio Exe. Now he's returning to present the Sunday afternoon show this weekend, 22 March, from 2pm - 6pm.
It comes at a time of national crisis that is affecting businesses and their workers, including the radio station. Mr Jupp was due to speak with Radio Exe's managing director Paul Nero about the issues on Sunday, but with a programme suddenly to fill, Radio Exe asked him if he'd like multi-task, by having the meeting whilst presenting a show. The programme's format will consist of Radio Exe's usual mix of local content and music for grown-ups and will ignore politics completely, despite Mr Jupp's new day job.
Paul Nero, who as well as being Radio Exe's managing director is its joint owner, says: "Like many small businesses right now, we needed to raise some policy issues with local MPs, of whom Simon is the newest in our broadcast area. Local radio can help businesses and listeners in times such as these, but only if we are able to continue trading. I need to make some compelling points to regulators and legislators, so getting Simon back into our studios provides that opportunity – he just didn't expect to be hosting a show at the same time. Fortunately for our listeners, he's also an assured broadcaster that people will enjoy hearing. Simon hasn't asked for a fee and is doing the show as a favour to us in his capacity as a broadcaster and local resident, not an MP."
Simon Jupp says: "Radio Exe is a superb example of what local radio should be about, providing exemplary local programmes to a sizable audience. The team is smaller than listeners would imagine from the quality of the output, which goes way beyond its license commitments set out by Ofcom, and hugely more than the larger network brands that have largely abandoned any local services. I'm really looking forward to being back on the air, and communicating with the wonderful people of Devon."
Long jail sentences for south west drugs gang
Cocaine brought into Devon
Devon boy goes missing
Family 'worried sick' about 13-year-old boy
Five Exeter Chiefs players in England squad
Cowan-Dickie, Hill, Nowell, Simmonds and Slade called up
Man stabbed in Torquay
Two men released on bail
Former lord mayor protests over road changes
Temporary restrictions made permanent
Queen Street temporary changes become permanent
And they're not the last!
On Air Now Radio Exe - Non Stop Playing Easy On Me Adele


Please note! If your device does not direct you to the corner of 148th and Seattle Hill Road as shown below, please input the address with Bothell as the city. Some GPS navigation devices (Google Maps) will direct you to a residential area when using the above address.
Note: We are on the 2nd floor accessed by the back parking lot by outdoor or indoor stairs. Evelator access is also available.
Located in SE Everett near the borders of Mill Creek, Bothell and Snohomish, Washington. Most of our students come from nearby, but some come from farther away like Seattle, Lynnwood, Marysville, Lake Stevens, and Monroe.


Ms Awa Kebbeh is an alumnus of Nusrat Senior Secondary School where she studied commerce as a field and graduated in 2017. She is currently studying Gender and Development at Management Development Institute where she actively participates in extracurricular activities.
Ms Kebbeh is passionate about health related issues and hopes to be a Nurse in the future. She is currently volunteering with Gambia Red Cross Society, Bundung branch where she give back to the society.
Ms Awa Kebbeh is currently working with the Networking and Partnership Department of Salimatou Foundation for Education and has being the most active volunteer of Month of April 2018.
Congratulations Awa Kebbeh, SaFE is proud of you!
First Cohort of SaFE Teen Girls Mentorship Program kicked off.


For those of Us who claim Christ and are Believers, We must always realize Our relationship with Him transcends all circumstances. This is why We can praise the Lord and enjoy His Presence in the middle of dark difficulties. To find Him in such times, exerts a lot of faith; but He is always near.
As Believers, We live on two planes simultaneously: the natural world, where adverse situations abound; and the supernatural world, where Christ reigns Supreme. Your trust-muscles empower you to experience His Presence even in Your hardest times. In fact, trials can both strengthen your faith and help you discern how much you actually trust the Lord.
Christ wants Us to work on strengthening Our trust-muscles. One way is to fill Our minds and hearts with Scripture. Another is to 'Seek His Face Continually.' Instead Of getting stuck in introspection, turn your thoughts toward Jesus. Make it a practice to affirm your faith in Christ frequently, whether you're feeling confident or inadequate. Remember that your adequacy rests in your relationship with Him. The Lord God Almighty makes you READY FOR ANYTHING AND EQUAL TO ANYTHING AND ANYBODY BY INFUSING INNER STRENGTH INTO YOU!


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CD REVIEW: Ambrose Akinmusire – Origami Harvest
By ljazzn on 24 October 2018 • ( Leave a comment )
Ambrose Akinmusire – Origami Harvest
(Blue Note 002866202. CD review by Jon Turney)
Imagine making music to accompany a roll call of young black men and women killed by supposed law-enforcers. Imagine living in a society where such a list grows steadily.
An American musician has no need to imagine: it is their world. Ambrose Akinmusire's searing new album is one response. Origami, he says, is a reference to the folding of people, not paper, Harvest to repetition, not plenitude.
Repetition has a place in the music, too. The naming of the dead is a device Akinmusire has felt compelled to use before. But how to inflect a lament when the conflict that brought the casualties stretches unbroken into the future? Perhaps that more complex challenge calls for more complex scoring from a composer?
The pieces here are certainly densely written, laying out parts for a bold alliance of the Mivos String Quartet, rapper Victor Vasquez (Kool A.D.) regular Akinmusire cohort Sam Harris on piano and Marcus Gilmore on drums. The sound is a rich brocade of contemporary classical, fluid hip-hop, funk, and jazz at its most flexible, each enriching the others.
The leader's trumpet is eloquent and incisive in several sections, but is not the main event. Vasquez is in the foreground for appreciable stretches, with arrestingly incantatory words, sometimes allusive, sometimes direct appraisals of the USA ("savage histories, brutal legacies, illusory democracies, feudal tendencies…"). The strings wax and wane, now elegiac, now almost savage, with some of the most attacking bowing you ever heard. Gilmore is remarkable throughout, whether nailing beats or furnishing intense but controlled commentary on everything else.
In the absence of a bass pulse, it's tempting to say the drummer binds all together, but that's not quite right. The singular mix here does work, because of the composer's strength of vision. But the forces in play work against each other as well as in mutual reinforcement.
Akinmusire's comment in the press release is worth noting, citing a series of oppositions and how: "Originally, I thought I put them all so close together that it would highlight the fact that there isn't as much space between these supposed extremes as we thought, but I don't know if that's actually the conclusion of it."
Well, no. And that seems fitting. Smoothing out the tensions between all the disparate elements he deploys would be a less effective response to the social rifts that charge the words here.
This is not music of consolation or commiseration. It is often an edgy, unsettling, listen, sometimes conveying an almost resigned defiance. The listener is afloat, but in deep water, alive with cross-currents even when apparently calm, and in danger of succumbing to a powerful undertow of melancholy.
It grips, because the unexpected collaborators here are emotionally as well as musically in tune. And because along with depth of emotion they all at times convey a sense of danger. It's the danger, for some, of being American. But it is manifest in many other countries too. Probably including yours.
Jon Turney writes about jazz, and other things, from Bristol. jonturney.co.uk. Twitter: @jonWturney
LINKS: Live review: Akinmusire Quartet at Stadtgarten in Cologne in May 2018
Richard Williams on MaeMae at the 2017 Berlin Jazz Festival
Categories: CD review
INTERVIEW: Italian/Swiss pianist Lorenzo De Finti (new album Love Unknown, Losen Records)

redpajama_set_name: RedPajamaCommonCrawl


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Home > Piano > Technics P50
Technics P50: A beautifully rich piano sound, a broad selection of voices and incredibly realistic keyboard touch response. All housed in a simple, stylish body thats compact and light enough to carry almost anywhere. Looking for a digital piano that delivers piano playing enjoyment and much, much more? The choice is easy: the Technics P50.
P50 User Manual
Technics sx-P50
Download Technics P50 Piano User Manual
Technics Piano
The Technics sx-P50 Portable Grand Piano was released in 2001 to critical acclaim. Featuring an incredibly robust aluminium casing with an attractive curved form-factor, the Technics P50 is an ideal stage piano and makes an excellent MIDI controller.
"Natural Response Action"
9 Instrumental Sounds
9 Organ Presets
64-note Polyphony
Piano 'String Resonance'
Sound Layering
MIDI Connectivity
Piano Tuning or Standard Equal Temperament
Technics P50 Demo
These are the built-in factory demos on the Technics sx-P50 Piano.
As I didn't have the correct cables to record the P50 piano directly into the computer, I sent the output from the piano into Technics KN7000 and then recorded the results using the USB cable and Technics Audio Recorder. This produces WAV files. From there I opened in Audacity and converted to MP3 files in order to give a reasonable file size on the website and good compatibility for browsers.
Technics P50: Graded Hammer Action
On a grand piano the key touch is heavier for low notes and lighter for high notes, changing in four steps from one end of the keyboard to the other. This change occurs naturally as a result of the thickness of the strings, the size of the hammers, and the presence or absence of a damper.
Technics' Natural Response Action Feels Like You're Playing a Concert Grand
Technics Natural Response Action replicates this progression by using four sets of graded hammers that are linked to the appropriate registers of a grand piano to provide a substantial, authentic response. Furthermore, the black keys feature a matte finish, reminiscent of the key texture on a concert grand.
The Natural Response Action provides the tactile "release" in the middle of a keystroke that is characteristic of grand piano keys.
Technics Dynamic Acoustics Technology Recreates the Sound of a Concert Grand
Highly regarded for its incredible realism, Technics Dynamic Acoustics technology is based on PCM recordings of a world-class concert grand piano after it has been meticulously tuned and adjusted. It is sampled at several dynamic levels across the keyboard in order to capture the variations in sound,
18 Realistic Sound to Explore
Thanks to the Technics concept of Dynamic Acoustics, the Technics P50 helps deliver incredibly realistic grand piano sound. It also offers the sound of an Electric Piano as well as other instrumental sounds, like Strings, Vocal or Organ.
You'll really appreciate the maximum 64-note polyphony, which provides virtually unlimited dynamic expression for your performances. You can even combine two different instrumental sounds, such as Strings and Grand Piano, for a beautifully rich, layered effect.
The sx-P50, Delivering Outstanding features in a Stylish, Compact Design
A keyboard that fits your lifestyle... even when space is limited.
More Exciting Technics P50 Features!
For convenience, the sx-P50 features an easy-to-read LED display.
Touch Sensitivity (Light, Normal, Heavy)
Select among three touch sensitivity settings to best suit the strength with which you hit the keys.
Adjusts the sound from mellow to bright in 5 steps.
Simply press the Transpose button to play in any key you desire.
Technics P50 Video
Technics P50 Discussion


"It won't be today," she said, starting to freak out again at the cold shadows and the scary man.
Death didn't live in the shadows as Gabriel had for the majority of his life.
Toby emerged from the early morning shadows of the forest.
The shadows clung to her as she stepped into the hallway.
The longer they talked, the deeper the clammy shadows sank into her.
A form melted from the shadows before her, and she held her breath.
A form melted from the shadows right before she reached it.
His death-dealers were fading into the shadows of the forest as the ground shook.
He sank into the shadows, at home in the darkness, watching.
More dark shadows lingered deep within the forest, watching over their leader.
Weller prodded him further to the shadows beyond before he answered.
Shadows covered half his face, rendering his chiseled features and low brow sinister.
The petite woman who materialized out of the shadows wasn't what he expected. Her flawless features were unremarkable, her large eyes turning colors faster than his.
The trees overhead rustled, and Toby yanked away, staring. Katie saw shadows but nothing else. Even so, she doubted these were the freaky underworld birds.
She couldn't read his thoughts, but she saw the shadows in his eyes.
Rhyn emerged from the shadows near the window, dressed in black with his hair tied back.
The moonlight formed shadows on his muscular chest.
Darian was in the shadows, dressed in his workout gear, splattered with blood.
The lights were on, but shadows crawled from the corners and choked the lights until they were shriveled, glowing orbs.
Shadows crawled over the world around her, and the tension in the air made it hard to breathe.
Her Gabriel, who spent his life a part of the shadows, radiated the quiet power of a deity that reached her from across the room.
From the shadows of the crypt, Gabriel waited until the half-brothers were gone to dump the contents of the velvet dice pouch into his palm.
Ne'Rin was closer to the door, and Kiera remained in the shadows inside the house, watching.
They sat that way for a long time, silently watching the evening shadows grow long and then consume the sky.
She rested her hands on his arms and they gazed out the window, watching the shadows darken on the farmstead.
Claire twisted to see who spoke and was struck by the tall, slender man who stepped from the shadows of the forest.
Dawn had come an hour earlier but only just managed to push away the shadows of night from the cloudy mountain hiding place that had become her home.
A few impressions stand out vividly from the first years of my life; but "the shadows of the prison-house are on the rest."
He needed the reminder of the good in the world, because he saw none of it from the shadows where he spent his life.


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Lion President Horace Harper (left) started his first club meeting of the incoming year with a bang. Lion Charlie Neville (center) was awarded the Club's highest honor, THE MELVIN JONES AWARD, by King Lion Harper and Past President, Dan Strauss (right). The award recognizes the outstanding services a Lion has made over the years to our community, District, State and Lions International. The award is issued by Lions Club International Foundation only by the local club's application demonstrating service above and beyond the call of duty. Lion Charlie is in charge of the club's vision program. He can be contacted at 352 536-6833.
The club's featured program was presented by Brian MacNeel, Crime Prevention Practitioner. Mr. MacNeel pointed out that central Florida was near the top in the US in trafficking cases. Numerous prevention tools were presented and offered. Particularly popular was a state of the art flashlight with an end cap, easily removed to slice seat belts in emergencies. Florida leads the nation in the number of people drowning in their automobile. Our weather and road conditions add to the problem. It was pointed out that the striping on our roadways are visible in only three feet of water, therefore, if you can not see the lines, do not drive into the puddle. Mr MacNeel shared his experiences as a combat instructor in the military as well as his years in law enforcement for a most informative meeting.
Lion Bill Siegenthaler of South Lake Quick Print brought a new eyeglasses drop box built by Lion Nick Jones to the club with beautiful sign graphics added. The drop box will be placed in Lucky's Food Market near Home Depot.
The club plans to continue running the shooting range as its primary fund raiser. It is located across from Tractor Supply on SR 50 in Groveland. It is open to the public from 8-noon on the second, third and fourth Saturdays. The third Saturdays are restricted to shotguns. Call Lion Dan Strauss, 717 278-7437 for further information.
The club meets on second Thursday of the month at St. Mathias Episcopal Church at 6:00 pm. Volunteers are needed. For information, call Lion Pres. Horace Harper, 352 708-5516.


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Defense Maven
Warrior Maven
Russia's T-14 Armata Tank is Now For Sale Around the World
VIDEO ABOVE: Northrop Grumman Electronic Warfare Saves Ships: Takes Out Enemy Missiles
Russia's Industry and Trade Minister Denis Manturov told state media earlier this year that Russia was planning to start work with foreign customers of the Armata tank in 2021 and had already received several prior requests.
by Peter Suciu
Throughout the Cold War, the Soviet Union had sold its main battle tanks (MBT) to foreign partners around the world, and some of those aging tanks are still in use today. The government of Laos was actually the last operator of the World War II-era T-34—but it is unclear if that Southeast Asian nation will upgrade to the T-14 Armata, and even if Laos doesn't add the new tank to its arsenal it does look like nations soon could.
This week the Head of Russia's Federal Service for Military and Technical Cooperation Dmitry Shugayev told the Serbian Glas javnosti newspaper that Russia has started promoting the latest T-14 tanks for export.
"Russian producers are ready to offer potential buyers both air defense systems, such as the S-300 and the S-400, and advanced aircraft and helicopters," Shugayev explained. "We are preparing the MiG-35 light fighter for sale and are promoting the latest T-14 'Armata' tank."
The Armata T-14 MBT was first demonstrated during the May 2015 Victory Parade in Moscow, and despite a reduction in Russian defense spending that came with lower oil prices earlier this year, the Russian military has continued with the production of the new tank. It is being overseen by Rostec Corporation, the Moscow conglomerate that specializes in consolidating strategically important companies in Russia's defense sector.
The T-14 is part of the Armata's heavily tracked standardized platform, which serves as the basis to develop a main battle tank, an infantry fighting vehicle, an armored personnel carrier and some other armored vehicles. The new combat vehicle is notable in that it features fully digitized equipment, an unmanned turret and an isolated armored capsule for the crew.
Work on the Armata project began in 2010 when the Russian Ministry of Defence terminated work on "Object-195"—the T-95 program. The entire project was seen to be a huge technological leap from Soviet-era military hardware designs and from the ground up the T-14 is very much distinct from past Soviet/Russian tank platforms.
Thus far, the foreign partners haven't been named, however, it is worth noting that the T-14 has undergone field testing in Syria—yet how extensive that testing was is still a matter of debate. According to reports in May, the Russian-built tanks took part in fighting with Syrian-rebels in the province of Latakia and three may have been hit from TOW-2B anti-tank systems.
The reports from Russian media outlet Репортёр (Reporter) even suggested that "one Armata was completely destroyed." While that hasn't been confirmed it wouldn't be the best selling point for potential foreign partners.
Peter Suciu is a Michigan-based writer who has contributed to more than four dozen magazines, newspapers and websites. He is the author of several books on military headgear including A Gallery of Military Headdress, which is available on Amazon.com.
SHOULD THE DEPLOYED LOW YIELD NUCLEAR WARHEADS ON THE D-5 MISSILE BE REVERSED
AN UPDATE: SHOULD THE DEPLOYED LOW YIELD NUCLEAR WARHEADS ON THE D-5 MISSILE BE REVERSED?
A Dumb Nuclear Trifecta
The Soviets proposed the freeze because their nuclear forces were already modernized
DID ARMS CONTROL DISAPPEAR DURING THE TRUMP ADMINISTRATION?
Is arms control in danger of disappearing? The short answer is no.
Don't Shoot the Polar Bears - Preventing War in the Arctic
While surely nobody wishes to open small arms fire in the vicinity of polar bears and penguins
Kris Osborn
US Special Ops Want A-29 Super Tucanos to Attack Terrorists in Africa
US-trained pilots with the Afghan Air Force have been attacking the Taliban with A-29 Super Tucano aircraft
Karl -Moderator
Pentagon Wants to Build 80 Plutonium Pits Per Year for Nuclear Weapons
The Pentagon has no plans to abandon its nuclear weapons arsenal
Russia Massively Arms it Attack Submarines With Cruise Missiles
The Russian Navy is massively arming up its fleet of attack submarines
Russia Arms Attack Submarines With New Hypersonic Missile
The Russian Navy is arming its attack submarines with a first-of-its kind submarine-launched hypersonic missile
NUCLEAR STABILITY, ARMS CONTROL AND THE NEW START TREATY EXTENSION
Pentagon Calls China's Test of DF-21D & DF-26 Anti-Ship Missiles 'Destabilizing'
The Pentagon is calling China's decision to fire off anti-ship missiles in the South China Sea concerning
Mshna


"It is one thing to learn about a part of history and other thing is to see it." That was the sentiment after the meditative and prayerful visit to the concentration camp of Auschwitz.
On July 27, about 400 members of the Brooklyn Diocese contingent, paid a solemn visit to the camp that is considered a symbol of terror, genocide and the Holocaust.
Jason Reyes and Matthew Perez, students at Xaverian H.S., Bay Ridge, said that the visit to the site where at least 1,100,000 people were murdered during World War II brought a deep sadness.
Father John Amann, pastor emeritus of Holy Family Church, Canarsie, said that coming to Auschwitz made the pilgrims feel the depths of human nature at its worst.
Perez said that he was touched by being able to walk around the place people were brought to be killed. The average life expectancy after arriving at Auschwitz was three months, said the person guiding the tour.
"All I could do really was stand there and read the sign and take off my hat out of respect because there is nothing that could be said to further encapsulate what comes from this visit," he said.
Grace Dolan, 17, of Blessed Trinity parish, Breezy Point, who reflected on the horrors that took place in Auschwitz said this indifference should be avoided at all cost.
Perez added that in this Year of Mercy, seeing the results of the worst of the human capacity for evil was a call to treat people differently and to bring about hope and kindness.
Amid the sadness, there was a sliver of heroism. The pilgrims visited the barracks of the martyred St. Maximilian Kolbe, a Polish Conventual Friar who surrendered his live so another prisoner might live.
St. John Paul II canonized Maximilian Kolbe in October 1982.
Ramirez added that knowing that "amid all the evil Maximilian brought a bit of light and hope also brings forth hope" amid the violence and death that we live in today's world.


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Festival ProgramSearch
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2023 Miami Jewish Film Festival
Woman in the Mirror
Expired January 26, 2023 4:45 AM
This film is eligible for the 2023 Miami Jewish Film Festival Audience Award! Watch the film and then cast your vote here.
Protected ContentThis content can only be viewed in authorized regions: United States of America.
If you would like to donate to support our efforts, you can do so by clicking here. You can also experience all the films streaming in the Festival's virtual program by purchasing an All-Access Virtual Pass by clicking here.
Nestled in a small New England town is a powerhouse of a ballet school. Its genesis includes the dramatic story of a prima ballerina defecting from the Soviet Union and her tenuous climb to personal and artistic freedom. Alexandra Koltun, a graduate of the prestigious Vaganova Academy and a driven ballerina, is leading a diverse group of ballet students in their difficult journey to become professional dancers. She recounts the struggles of her father and family and fearing similar limitations as a Soviet Jew, makes a dangerous leap into what she hopes will be a new and freer life. Teaching ballet, she is shaping not only her students' bodies, but also their characters, as she tries to instill in them that same strength that served her well throughout her life.
Closed captions for this film were made possible with the generous support of the Miami Jewish Abilities Alliance, a program of the Greater Miami Jewish Federation.
Tatyana Bronstein
Alexandra Koltun, Alex Lapshin
Closed captions available


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Are you familiar with Fridoc, the IIR's database?
Thèmes : N/A
Mots-clés : N/A
Readers of the paper Bulletin (or the e-Bulletin) of the IIR are regularly informed on the latest articles and publications in all refrigeration fields, thanks to the Abstracts section. Fridoc now contains over 81 500 references to articles and publications, i.e. all the references compiled in the Bulletin since 1982. Abstracts of over 500 papers from the proceedings of the Beijing Congress held in August 2007 have now been added to Fridoc, which now contains 2500 references to CO2, 1000 references to ammonia and over 700 to slurry/slurries. Fridoc is accessible online and constitutes the largest database entirely devoted to refrigeration and its applications. All members of the IIR have free access. Find out more and arrange a free trial: info@iifiir.org In order to become a member of the IIR and benefit from Fridoc free of charge and a wide range of other products and services, please contact: s.phalippou@iifiir.org


A mother of a K2 Martial Arts student, Kelly Freisen, was so proud of her son Joshua who used the confrontation avoidance and anti bullying techniques taught by his K2 Martial Arts instructor. Little Joshua had a run in with another child who tried to bully him while at Cosmic Adventures. Joshua was not only able to deflect and defend himself against the bullying behaviour for his own welfare, he was also able to use the tools learnt at K2 Martial Arts to protect his friends as well.
This types of situations are all too common nowadays. One of our primary goals at K2 Martial is to help children learn to deal with instances in a very calm and decisive manner. Our Martial Arts curriculum has anti bullying techniques embedded within in it, in hopes that our students will never have to use it, but also the confidence that they will be well prepared if the need arises.


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Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever
Ahmet Gül1,
Huri Ozdogan2,
Burak Erer1,
Serdal Ugurlu2,
Ozgur Kasapcopur3,
Nicole Davis4 &
Serhan Sevgi5
This open-label pilot study aimed to investigate the efficacy of canakinumab in colchicine-resistant familial Mediterranean fever (FMF) patients.
Patients with one or more attacks in a month in the preceding 3 months despite colchicine were eligible to enter a 30-day run-in period. Patients who had an attack during the first run-in period advanced to a second 30-day period. At the first attack, patients started to receive three canakinumab 150 mg subcutaneous injections at 4-week intervals, and were then followed for an additional 2 months. Primary efficacy outcome measure was the proportion of patients with 50 % or more reduction in attack frequency. Secondary outcome measures included time to next attack following last canakinumab dose and changes in quality of life assessed by SF-36.
Thirteen patients were enrolled in the run-in period and 9 advanced to the treatment period. All 9 patients achieved a 50 % or more reduction in attack frequency, and only one patient had an attack during the treatment period. C-reactive protein and serum amyloid A protein levels remained low throughout the treatment period. Significant improvement was observed in both physical and mental component scores of the Short Form-36 at Day 8. Five patients had an attack during the 2-month follow-up, occurring median 71 (range, 31 to 78) days after the last dose. Adverse events were similar to those observed in the previous canakinumab trials.
Canakinumab was effective at controlling the attack recurrence in patients with FMF resistant to colchicine. Further investigations are warranted to explore canakinumab's potential in the treatment of patients with colchicine resistant FMF.
ClinicalTrials.gov NCT01088880. Registered 16 March 2010.
Familial Mediterranean fever (FMF), the most common form of hereditary autoinflammatory disorder, is characterized by recurrent attacks of fever with serosal or synovial inflammation, generally lasting 12 to 72 hours [1]. It has also been associated with increased risk of secondary amyloidosis, mainly affecting renal and vascular function in untreated or insufficiently treated patients with FMF.
Colchicine, the standard of care for patients with FMF, has been considered as safe and effective in the majority of the patients for reducing both the frequency of inflammatory episodes and the risk of developing amyloidosis [2–4]. However, there are currently no effective and approved alternatives for FMF patients who are intolerant to colchicine, and dose reductions due to adverse effects may result in diminished efficacy. In addition, approximately 5−10 % of patients with FMF continue to have frequent inflammatory episodes despite receiving the highest tolerable doses (1.5 to 2.0 mg/day) of colchicine, which are considered to be within the effective range.
The majority of FMF patients have autosomal recessive inheritance associated with mutations in the MEFV gene, which encodes pyrin protein [1]. FMF-related MEFV mutations, which affect pyrin-mediated regulation of caspase 1 activity in the inflammasomes, are associated with increased IL-1β production in mice and humans [1]. Therefore, inhibition of IL-1 activity may decrease both frequency and severity of acute attacks in patients with FMF. Several reports of patients with FMF being successfully treated with agents blocking IL-1 activity, mainly with daily injections of the recombinant form of IL-1 receptor antagonist (IL-1Ra), anakinra, have confirmed the critical role of IL-1 in the pathogenesis FMF [5, 6].
The objective of this study was to evaluate the efficacy and safety of canakinumab, a fully human anti-IL-1β monoclonal antibody with a half-life of approximately 4 weeks, that binds to human IL-1β and neutralizes its proinflammatory effects, in adolescent and adult patients with FMF, who are resistant or intolerant to higher doses of colchicine.
The present study was an investigator-initiated, open-label exploratory trial that included adolescent and adult FMF patients with active disease despite receiving the highest tolerable doses of colchicine (1.5 to 2.0 mg/day). All patients had a typical type I phenotype, fulfilling the criteria for FMF diagnosis [7], along with at least one of the exon 10 mutations in the MEFV gene. Patients with end-organ dysfunction due to secondary amyloidosis, active tuberculosis or any other infectious diseases, or a history of malignancy within the last 5 years were excluded from the study.
Colchicine-compliant patients with a history of one or more attacks per month within 3 months before the screening were eligible to enter the first 30-day run-in period. Patients who had at least one attack during that period advanced to a second 30-day period, and they received their first dose of canakinumab upon the first attack they experienced during this second 30-day run-in period.
The treatment period started with the first injection, and patients received a total of three subcutaneous injections of canakinumab 150 mg at 4-week intervals. The canakinumab dose could be increased to 300 mg, if an attack occurred between the first and second doses. Stable doses of colchicine (1.5 to 2.0 mg/day) were allowed throughout the study without any dose modification, and compliance was followed tightly throughout the study. After the 12-week treatment period, the patients were subsequently followed for up to 2 months or until the next attack.
FMF attacks were confirmed by presence of fever, clinical findings of serositis/arthritis, and elevated C-reactive protein (CRP) levels. Details of each attack (duration, type, severity, maximum body temperature) were recorded in diaries. Diaries were dispensed to the colchicine-resistant FMF (crFMF) patients at each visit to record the occurrence of any attacks between the scheduled visits.
The primary outcome measure was the proportion of patients with 50 % or more reduction in time-adjusted frequency of attacks. Due to the unequal pre-treatment and treatment periods, attack rates were adjusted to the 84-day treatment period compared with the pre-treatment periods. Secondary outcome measures included the percentage of patients with no attacks in the treatment period, time to next attack after the last canakinumab administration, changes in quality of life assessed by the 36-item short-form health survey (SF-36), and serum levels of CRP and serum amyloid A (SAA) proteins. Physicians' and patients' global assessments of control of FMF since the last visit and response to treatment at the end of the treatment period were also measured using a modified 5-point scale [8]. All adverse events and laboratory values were recorded at each visit for the assessment of safety of canakinumab treatment.
Istanbul Faculty of Medicine Ethics Committee and Ministry of Health approved the study protocol, and all patients provided written informed consent before the screening. Exploratory analyses were performed using descriptive statistics.
A total of 13 patients with crFMF were screened and included in the first 30-day run-in period. Nine patients (median age 22 years, range, 12 to 34) had ≥1 attack during that period, advancing to the second 30-day period, and began their treatment period by starting canakinumab treatment at the first observed attack within this period. Patient baseline demographic characteristics and MEFV genotypes are summarized in Additional file 1: Table S1.
All nine patients in the treatment period achieved the primary endpoint of ≥50 % reduction in frequency of attacks compared with the time-adjusted pre-treatment frequency of attacks. During the treatment period, only one patient, who was p.Met694Val homozygous and receiving 2 mg/day colchicine, had an attack of peritonitis on day 54. No patient qualified for a canakinumab dose increase between the first and second injections. The time-adjusted frequency of attacks over 84 days observed in the screening and run-in periods, including the baseline attack (median 3.29, range 2.47 to 4.2), decreased dramatically during the treatment period (median 0, mean 0.11).
Five patients, all p.Met694Val homozygous and receiving 2 mg/day colchicine, subsequently experienced an attack within the 2-month follow up, which occurred at a median 71 days (range 31 to 78 days) after the last canakinumab injection (Fig. 1). Median baseline CRP and SAA levels (58 mg/L and 162 mg/L, respectively) on day 1 of canakinumab administration normalized (2.5 mg/L and 5.8 mg/L, respectively) by day 8, and remained low throughout the study (Additional file 2: Figure S1). No other significant laboratory abnormalities were noted.
Number and severity of familial Mediterranean fever attacks observed throughout the study period. Severity of the attack was assessed according to patients' assessment in relation to their previous experiences
The median SF-36 physical and mental component scores increased dramatically at day 8 compared with baseline scores and continued to improve throughout the treatment period (Additional file 3: Figure S2). Compared with baseline, the physician's and patient's global assessment of crFMF control improved with canakinumab treatment, and overall treatment response was reported as being very good both by physicians (for all patients) and patients (seven of nine patients) at the end of study (Fig. 2).
Physician's global assessment of control of familial Mediterranean fever over the previous month. EOS end of study
Eight patients reported at least one adverse event; headache (n = 4) and upper respiratory tract infection (n = 2) were the only adverse events reported by more than one patient (Table 1). All adverse events were mild or moderate except one, which was a severe headache. None of the patients discontinued the trial due to an adverse event. A mild, local injection-site reaction was recorded in two patients on at least one occasion.
Table 1 Adverse events observed in nine patients during the canakinumab treatment period
One of the patients became pregnant during the treatment period after the third canakinumab dose and gave birth to a healthy son.
This open-label pilot trial showed that monthly canakinumab 150 mg subcutaneous injections prevented attacks in patients with crFMF, and only one of nine patients experienced an attack during canakinumab treatment. The safety profile of canakinumab in this small group of patients was similar to that of larger controlled trials in other hereditary autoinflammatory conditions [8–10].
Colchicine has long been used to prevent inflammatory attacks and reduce the risk of secondary amyloidosis in patients with FMF. Despite the efficacy of colchicine, some manifestations, such as arthritis, are less responsive to colchicine [11]. Furthermore, 5−10 % of patients are non-responders to colchicine [12], and the number of FMF patients who are either intolerant or resistant to colchicine and continue to experience frequent and/or severe inflammatory attacks is increasing [13].
Given the association of type and number of MEFV variations with increased production of IL-1β, several case reports of patients treated with either anakinra or canakinumab have suggested the potential efficacy of IL-1 blockade in colchicine-resistant patients and those with amyloidosis [5, 6]. Additionally, in a recent randomized, double-blind, alternating-treatment trial the frequency of attacks decreased with weekly injections of rilonacept, another anti-IL-1 drug, consisting of humanized IL-1 type 1 receptor, IL-1 receptor accessory protein and the Fc portion of IgG1 [14]. All three drugs block IL-1 beta activity, but there are some differences, mainly resulting from the half-lives of these drugs, the shortest being for anakinra, requiring injections at least once daily, and the longest being for canakinumab, requiring monthly or bi-monthly injection intervals, which may affect the quality of life of patients. There is no study comparing the dynamics of IL-1 beta secretion in patients with crFMF with those in patients with cryopyrin-associated periodic fever syndrome (CAPS) [8, 9]. Therefore, in this pilot trial, we aimed to test the efficacy and safety of canakinumab in patients with crFMF by 4-weekly administration intervals for 3 months and followed them up for 2 months to observe any recurrence of inflammatory attacks. In this follow-up period there was an inter-individual variability in the timing of recurrent attacks, with a range of 31 to 78 days after the last dose in five patients, and possibly reflecting differences in their inflammatory activity. Randomized controlled trials are expected to provide further data about the optimum dosage and administration intervals of canakinumab in patients with crFMF.
The limitations of this small exploratory study were its open-label design, relatively short treatment period, and lack of formal definitions for disease severity and colchicine resistance. However, inclusion of mainly patients with FMF with two penetrant mutations and ≥1 attack per month despite receiving the highest tolerable doses of colchicine, together with confirmation of attacks and colchicine-compliance during the run-in period, represent a real-world patient cohort with few treatment options.
In conclusion, the results of the present pilot trial suggest that canakinumab may be an effective and safe treatment option for colchicine-resistant and colchicine-intolerant patients with FMF, and warrant further investigations to explore its efficacy, safety and optimum dosage and administration intervals in this subset of FMF patients.
crFMF:
colchicine-resistant familial Mediterranean fever
CRP:
FMF:
SAA:
SF-36:
Short form-36
Masters SL, Simon A, Aksentijevich I, Kastner DL. Horror autoinflammaticus: the molecular pathophysiology of autoinflammatory disease. Annu Rev Immunol. 2009;27:621–68.
Zemer D, Revach M, Pras M, Modan B, Schor S, Sohar E, et al. A controlled trial of colchicine in preventing attacks of familial mediterranean fever. N Engl J Med. 1974;291:932–4.
Dinarello CA, Wolff SM, Goldfinger SE, Dale DC, Alling DW. Colchicine therapy for familial mediterranean fever. A double-blind trial. N Engl J Med. 1974;291:934–7.
Zemer D, Pras M, Sohar E, Modan M, Cabili S, Gafni J. Colchicine in the prevention and treatment of the amyloidosis of familial Mediterranean fever. N Engl J Med. 1986;314:1001–5.
Meinzer U, Quartier P, Alexandra JF, Hentgen V, Retornaz F, Koné-Paut I. Interleukin-1 targeting drugs in familial Mediterranean fever: a case series and a review of the literature. Semin Arthritis Rheum. 2011;41:265–71.
Soriano A, Verecchia E, Afeltra A, Landolfi R, Manna R. IL-1β biological treatment of familial Mediterranean fever. Clin Rev Allergy Immunol. 2013;45:117–30.
Livneh A, Langevitz P, Zemer D, Zaks N, Kees S, Lidar T, et al. Criteria for the diagnosis of familial Mediterranean fever. Arthritis Rheum. 1997;40:1879–85.
Lachmann HJ, Kone-Paut I, Kuemmerle-Deschner JB, Leslie KS, Hachulla E, Quartier P, et al. Use of canakinumab in the cryopyrin-associated periodic syndrome. N Engl J Med. 2009;360:2416–25.
Kone-Paut I, Lachmann HJ, Kuemmerle-Deschner JB, Hachulla E, Leslie KS, Mouy R, et al. Sustained remission of symptoms and improved health-related quality of life in patients with cryopyrin-associated periodic syndrome treated with canakinumab: results of a double-blind placebo-controlled randomized withdrawal study. Arthritis Res Ther. 2011;13:R202.
Ruperto N, Brunner HI, Quartier P, Constantin T, Wulffraat N, Horneff G, et al. Two randomized trials of canakinumab in systemic juvenile idiopathic arthritis. N Engl J Med. 2012;367:2396–406.
Ben-Chetrit E, Levy M. Colchicine prophylaxis in familial Mediterranean fever: reappraisal after 15 years. Semin Arthritis Rheum. 1991;20:241–6.
Ben-Chetrit E, Levy M. Familial Mediterranean fever. Lancet. 1998;351:659–64.
Lidar M, Yonath H, Shechter N, Sikron F, Sadetzki S, Langevitz P, et al. Incomplete response to colchicine in M694V homozygote FMF patients. Autoimmun Rev. 2012;12:72–6.
Hashkes PJ, Spalding SJ, Giannini EH, Huang B, Johnson A, Park G, et al. Rilonacept for colchicine-resistant or -intolerant familial Mediterranean fever: a randomized trial. Ann Intern Med. 2012;157:533–41.
We wish to thank all patients who participated in this study. This study was designed and conducted as an investigator-initiated trial. Novartis Pharmaceutical Corporation approved the study protocol and provided support for the trial. A. Gul, H. Ozdogan and O. Kasapcopur received research grants and honorariums from Novartis Pharmaceutical Corporation. B. Erer and S. Ugurlu have no conflict of interest; and S. Sevgi and N. Davis are employees of Novartis Pharmaceutical Corporation. None of the authors have non-financial competing interests.
Istanbul Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, 34093 Fatih, Istanbul, Turkey
Ahmet Gül & Burak Erer
Cerrahpasa Faculty of Medicine, Department of Internal Medicine, Division of Rheumatology, Istanbul, Turkey
Huri Ozdogan & Serdal Ugurlu
Department of Pediatrics, Istanbul University, Istanbul, Turkey
Ozgur Kasapcopur
Novartis Pharmaceutical Corporation, East Hanover, NJ, USA
Novartis Pharmaceutical Corporation, Istanbul, Turkey
Serhan Sevgi
Ahmet Gül
Huri Ozdogan
Burak Erer
Serdal Ugurlu
Correspondence to Ahmet Gül.
A. Gul, H. Ozdogan and O. Kasapcopur received research grants and honorariums from Novartis Pharmaceutical Corporation. B. Erer and S. Ugurlu have no conflict of interest; and S. Sevgi and N. Davis are employees of Novartis Pharmaceutical Corporation.
None of the authors have non-financial competing interests.
AG conceived of the study, and participated in its design, coordination and analysis of the results; and he helped to draft the manuscript. HO and OK participated in its coordination and helped to analyze the data and draft the manuscript. BE and SU participated in the coordination and execution of the trial and revised the manuscript. SS and ND participated in the design and coordination of the study, performed the statistical analysis, and revised the manuscript. All authors read, contributed and approved the final manuscript; and all agree to be accountable for all aspects of the work in ensuring that questions related to the accuracy or integrity of any part of the work are appropriately investigated and resolved.
Additional file 1: Table S1.
Demographics and baseline characteristics of the patients with familial Mediterranean fever (FMF) during the enrollment into the treatment period (n = 9). CRP C-reactive protein, ESR erythrocyte sedimentation rate, SAA serum amyloid A. (DOCX 16 kb)
Additional file 2: Figure S1.
Serum C-reactive protein (CRP) and serum amyloid A (SAA) measurements during the treatment and follow-up periods. EOS end of study. (DOCX 61 kb)
Short form-36 (SF-36) physical component summary (PCS) and mental component summary (MCS) scores during the treatment and follow-up periods. EOS end of study. (DOCX 53 kb)
Gül, A., Ozdogan, H., Erer, B. et al. Efficacy and safety of canakinumab in adolescents and adults with colchicine-resistant familial Mediterranean fever. Arthritis Res Ther 17, 243 (2015). https://doi.org/10.1186/s13075-015-0765-4
Anakinra
Familial Mediterranean Fever Patient
Mental Component Score


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'Fear The Walking Dead' Wants To Mount A Rick Grimes Rescue Mission
Paul Tassi Senior Contributor
News and opinion about video games, television, movies and the internet.
Fear the Walking Dead may be having yet another rocky season, but it's one that is interesting for TWD lore reasons, at the very least.
We ended up knowing very little about the group that took Rick by the end. They have helicopters, they recruited Jadis to give them people, 'As' who were recently bitten, 'Bs' who were not. And that's kind of it. And yet, this group has now shown up in Fear the Walking Dead as essentially the main antagonists, not that we've learned much else about them yet other than their passion for maps and ridged body armor.
In interviews, the Fear cast is starting to talk about the connection and how they hope to be included in the upcoming Rick Grimes movies, which will really dive into mysteries of this group. Fear's own Al has been abducted by the group, and it's not yet clear if that's a permanent development, or something that will be resolved this season. At the end of this week, it sort of looked like the helicopter people were leaving the area entirely, but obviously the group isn't just going to leave Al behind.
"If there's anyone who would be in the movie with Rick, it would be Al," Daniel Salazar's Rubén Blades told TV Guide. "I hope they sneak Salazar in there to go rescue Al."
Lennie James was also asked about getting to be in the movies with Rick.
"I had a great time working with Andy," said James. "I'd work with him any day of the week. So any opportunity to be back in front of the camera, hanging out on set with him, I would absolutely jump at."
Only four episodes in, it's hard to tell where this is going. Supposedly Fear the Walking Dead is currently in a timeline that is eight months behind when Rick was taken by the helicopter people. So technically Al is the first victim of the group out of both casts.
The Rick Grimes movies are starting to assemble what could be a cast full of known faces. There's Rick, obviously, but also Jadis will likely be there as well, since she left with him and is affiliated with this group. It's also been confirmed that Heath disappeared because he was abducted by this group, so he could return (this feels like a ret-con to me, but whatever). From Fear, there's Al, if she's not returned to the core group. And really, depending on how this season goes, any number of Fear cast members could show up in Rick's new storyline considering how much they're directly interacting with this group this season. Finally, there's Michonne from TWD, as Danai Gurira is set to leave the show sometime early next season as she moves on to other projects. And yet it's easy to imagine that instead of the show killing her off, she goes off in search of Rick or is abducted herself, and then ends up showing up in the movies as Andrew Lincoln's co-star.
I doubt any of the Fear cast actually knows what's going on with the movies yet. I'm not even positive AMC knows yet, as we're not likely to see one until at least late 2020. Fundamentally I do like the helicopter group as a mystery presence in the show as they do not appear to be linked to the comics at all, and it's something that keeps the fanbase guessing. I'm not sure how I feel about these Rick Grimes movies, as it's going to be weird to have those exist as like, odd, two-episode features on AMC every year or so, but we'll see how it goes.
As for the Fear cast, I'd be surprised if more than one or two made the leap into those films, and if they do, they may never be coming back.
Follow me on Twitter, Facebook and Instagram. Read my new sci-fi thriller novel Herokiller, available now in print and online. I also wrote The Earthborn Trilogy.
Paul Tassi
I write about video games, television, movies and the internet.


Techie – programmed to your liking this crisp Cherry and citrus Lemon is the perfect formula of sweet with a tiny bit of tang.
Techie by Diamond Vapor is recommended for use with sub ohm tanks and kits because of its 70% VG ratio. This ratio also allows for a balance between cloud and flavor production when vaped.
Techie from Revenge is available as a 50 ml shortfill, each bottle has room for a 10ml nicotine shot. For example, adding an 18mg, 10ml nic shot will create 60ml of 3 mg e-liquid.


Operation Banner was the operational name for the British Armed Forces' operation in Northern Ireland from August 1969 to July 2012. It was initially deployed at the request of the Unionist government of Northern Ireland to support the Royal Ulster Constabulary (RUC). After the 1998 Belfast Agreement, the operation was gradually scaled down. It continued, however, to support the Police Service of Northern Ireland (PSNI) from 2001. Its role was to engage in counter-terrorism and public-order operations in response to the Troubles, and to assist the Government in its goal of restoring normality in Northern Ireland.
A key event in the campaign was Bloody Sunday - a civil rights march turned nasty with an amount of youths starting a riot against an RGJ (Royal Green Jacket) checkpoint. They responded with the usual anti-riot tactics, and eventually the Parachute Regiment (The Paras) was called in, and they shot dead 13 civilians.
The peacekeeping role of 1969 quickly deteriorated. Relations with the disgruntled Catholic minority turned sour, irreparably, after paratroopers killed 14 people in a 1972 shooting still remembered as Bloody Sunday. Soldiers were soon fighting urban gun battles with the Irish Republican Army. In 1972, the worst year of the conflict, 134 soldiers were killed, almost as many as have died in the past four years in Iraq.


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CAS Spotlight Fall 2014
From the Dean: Reflecting on 25 Years
By Terence Langan
As I begin my 25th year at the University of St. Thomas, I find myself looking backward at all that has changed in that time, as well as looking forward to all that will be.
To no one's surprise, much has changed in the past 25 years. As a dean, the most obvious changes have been in the people with whom I work every day. Many valued colleagues have retired and many excited and motivated young professionals have been hired. In my home department of economics, where I spent my first 15 years at the university, 10 of the current 15 faculty members were not here when my colleagues Agapitos Papagapitos, Rob Riley and I arrived in 1990. Seven of those 10 have been hired since I became associate dean in 2005. Certainly, a similar pattern would hold true in the other academic departments in the college.
In terms of new colleagues, much has changed in just the last several months. For example, in the summer of 2013 we welcomed Dr. Julie Sullivan, our first lay president and our first female president. In summer 2014 we welcomed Dr. Richard Plumb as our new executive vice president and provost. Early in 2015, we look forward to welcoming Father Larry Snyder, current president of Catholic Charities for the United States, as our new vice president for mission.
In addition to personnel changes, many other changes have occurred, too. We have grown the undergraduate program, adding both students and new major and minor fields of study. We have added entirely new graduate programs. We have built or remodeled many facilities, including classroom buildings and residence halls. While this may seem like a great deal of change in a short period of time, the pace of change has been a constant for quite some time now. One needs only talk to some of our faithful, long-time alumni to learn that is true.
As I look forward, I know that 25 years from now much more will have changed. We will have new programs that we cannot even imagine today. Some of our more recent hires will be in leadership positions by then. And I am convinced that St. Thomas will be more widely recognized both nationally and internationally than it is today for all that we do.
But what won't have changed in the next 25 years are the same things that, in my experience, have not changed during the past 25 years. These are the values that make St. Thomas what it is today. Chief among these is the close interaction between students and dedicated faculty and staff that you do not find at many other institutions. Further, the liberal arts mission of the university will mean that we continue to educate students to think critically, act wisely and work skillfully. And our Catholic character will continue to aid us in developing morally responsible leaders who advance the common good.
The last 25 years have been a period of great success at the University of St. Thomas. The next 25 years will be even better. I invite you to join us in making that happen.
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Assault on Free Speech
Assault on Free Speech Overturned
When politicians face too much heat from the people, they try to do things like enact campaign finance reform.
And eventually, the Supreme Court decides that these efforts to keep the people at bay run afoul of the First Amendment.
Several years ago, my former boss, Speaker Denny Hastert, tried to stop moderate Republicans, like Chris Shays and John McCain, from joining with Democrats in passing campaign finance reform.
Hastert was suspicious of the real intentions of the Democrats. He knew, for example, that many of the so-called good government groups that were pushing for so-called reform, were actually funded by George Soros and his Open Society movement.
Hastert suspected that Soros, who also funded MoveOn.org and several other liberal-leaning Democrat groups, had no intention of taking money out of politics. He suspected that Soros intended to destroy the political parties to give him much more ability to dominate the political landscape.
Of course, that is exactly what happened. The political parties, who could no longer solicit soft-money donations from pro-business groups and corporations, became less important in get out the vote operations. The Republicans didn't have the money or the ability to build the political operations that Big Labor had (because Big Labor confiscated money from its members to pay for political activities). Nor did Republicans have the multi-billionaires (like Soros or his friend Steve Bing) to fund similar organizations, like MoveOn.org or Center for American Progress.
So, the Republicans were at a strategic disadvantage because of campaign finance reform, thanks to the Democratic leadership, George Soros, and Republicans who didn't fully understand what they were doing to themselves. And, the two biggest proponents of the law, Chris Shays and John McCain, found out the hard way that by destroying their own political party, they were destroying their own campaigns (Shays for re-election to Congress, McCain for the White House).
But, besides the idiocy of Republicans slitting their own throats by supporting a campaign reform bill that was constructed to eliminate the Republican Party, there is the whole principle of the thing.
And that principle, that somehow the government should be put in charge of regulating what you can say about politicians and what you can't say about politicians, is so fundamentally against the whole concept of free speech that is literally makes my head spin.
Politicians hate to see attack ads that are run against them, just as they give their approval to attack ads that take out their political opponents. Incumbents especially hate to see outside groups run campaigns against them, because, well, they don't want to lose their jobs. That, of course, is a completely natural and human reaction.
But that makes for a dangerous and terrible reason to give those politicians the power to stop those campaigns from running against them.
Tuesday's election had one clear lesson. The American people believe that the political class is not listening to them. But actually, I think the politicians can hear the people just fine, which is why they try to pass laws like campaign finance to keep themselves in power and take power away from those who would oppose them.
I applaud the Supreme Court for sticking up for the Constitution. It's about time.


Police investigating the murder of Grace Millane are looking for a shovel believed to be related to the enquiry.
A photograph of a similar Atlas Trade hardwood long handle, round mouth shovel is being released.
Police would like to hear from anyone who may have found this item anytime after Monday 3 December.
At this point we don't know where this item is. It could be anywhere between the Scenic Drive and central Auckland areas. Someone may have come across it, picked it up and taken it home. We need to speak to that person or anyone who has seen it.
The scene examination at Scenic Drive is now complete.
Hundreds of calls have been made to the 0800 number and officers are continuing to work their way through all of the information provided.
Finally, I am are aware that there is a great deal of public speculation about what happened to Grace. It is with great reluctance that I will only confirm the following, and say that Grace's body was intact when it was recovered.
Media please note; DI Beard is not available for interviews today.


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Why Were Mueller's Questions for Trump Leaked?
For months President Trump's legal team has been battling with Special Counsel Robert Mueller over whether the president will sit for an interview, and under what conditions the chat might occur. Now the New York Times has published a list of the four dozen or so questions Mueller would like Trump to answer.
The questions mostly cover topics Mueller is already known to be investigating, such as Trump's reasons for firing FBI director James Comey, why he publicly attacked Attorney General Jeff Sessions, and what he knew about Don Jr.'s meeting with Russians in Trump Tower. While they provide insight into the special counsel's case, there's only one truly surprising question: "What knowledge did you have of any outreach by your campaign, including by Paul Manafort, to Russia about potential assistance to the campaign?" So far there have been no public reports about Trump's former campaign manager asking Russia for help.
Times reporter Michael Schmidt elaborated on MSNBC, seeming to confirm that the document came from Trump's side (which makes sense because Mueller's team has not been known to leak).
Still, why would someone close to Trump's legal team want to release a road map of the president's potential missteps? Here are the leading theories.
Trump has said publicly that he's "looking forward" to talking with Mueller, and he's reportedly said in private that he's "champing at the bit" to sit for the interview. Trump seems to think the special counsel's probe will come to a speedy end if he's given the opportunity to explain himself, but no sane lawyer would agree.
This almost certainly comes from team Trump--current or past members. Why would they leak? Pure speculation but I think they need help in persuading Trump NOT to talk to Mueller, and are counting on the outcry. They may be afraid to oppose on own since Trump wants 2talk.
But there's a piece that doesn't fit. The Times reported earlier this month that Trump's lawyers were drafting a proposal that would have allowed him to be interviewed, but then the raid on Trump fixer Michael Cohen "damaged" trust with the special counsel's office. CNN said the raid made Trump's team reevaluate whether he should do the interview. If Trump was already leaning against cooperating with Mueller, why launch a risky public campaign to argue that point?
just talked to Giuliani who said his role on Trump team is limited. He worked with Mueller at DOJ & as NYC Mayor (Mueller at FBI) He hopes knowing Mueller can help bring the investigation to conclusion, saying it "needs a little push." How soon? "maybe a couple of weeks"
If that's the idea, it's already worked on Sean Hannity. After declaring on Monday night's broadcast that "I am told by my sources tonight that the New York Times is full of crap," he suggested Mueller was the source of the leak (despite what the Times article says), and argued that federal prosecutors have no business questioning the president's intent.
"How stupid is it? They want to get in the president's mind? Did you ever think of firing Mueller? When he never fired Mueller, and he has every right to fire Mueller, constitutionally," Hannity fumed.
That other topic Hannity was bemoaning in a fact-free fashion brings us to a third theory: perhaps Mueller's questions were leaked in order to put pressure on Republican lawmakers to shut down the special counsel's probe, before it's too late.
Of course, it's possible Mueller's questions were leaked to accomplish multiple goals. Maybe the plan was to make Hannity even angrier than usual, and let him convince Trump, his House allies, and other Fox News viewers that Mueller can't be allowed to ask the president to explain himself.


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Home Womens Rights Initiative news on womens rights violence against women The Injustice of Justice
The Injustice of Justice
JAIDEEP MAZUMDAR IN TIMES OF INDIA
When a 'court' in West Bengal ordered the gang-rape of a young woman this week for the 'crime' of having a liaison with a married man from another community and village, it, obviously and understandably, sent shock-waves across the country. But what few know is that such kangaroo courts, known as 'shalishi adalats', operate in vast swathes of Bengal, especially its rural hinterland, and have even been known to hand out death sentences. And rarely have those handing down such Talibanesque diktats been brought before the law.
Shalishi, a Bengali word of Persian origin, means mediation or arbitration. But what actually happens at these kangaroo courts is a mockery of mediation. Though they are supposed to handle and resolve only petty civil disputes, these adalats pass judgement, and more often than not very flawed and biased ones, on a range of crimes ranging from thefts and extra-marital affairs to rape. In most rape cases, the accused, especially if they come from relatively affluent or influential families, get away with just small fines.
Those who defy diktats have to pay a heavy price. Take the case of Munirul Haque of Betla village in East Midnapore district. A 'shalishi adalat' presided over by Nizamuddin Alam, a local Trinamool Congress leader, asked Munirul to pay a fine of Rs 25,000 for allegedly making a pass at the daughter a trader in the village in September last year. Munirul, a poor farm labourer, said that he could not pay such a huge amount and pleaded for a waiver of the fine. Nizamuddin, a cousin of the trader, then decreed that in lieu of the fine, Munirul would have to give his 16-year-old daughter in marriage to a 46-year-old man who already had two wives. Munirul had to agree because he had no alternative.
These courts are whimsical in dishing out sentences. Adultery, for instance, could attract anything from a death sentence to a fine of a few thousand rupees, while a petty thief could expect to be fined, flogged in public or even banished from the village. "It all depends on the financial and social status of the accused, the mood of the elders of the village who are members of the shalishi court and their relationship with the accused or his or her family. If a woman from a well-to-do and influential household is accused of an extra-marital relationship, chances are she would be let off with a warning and a fine. But the same 'offence' by a woman of a poor family would attract a much stiffer sentence, like being tonsured or paraded naked around the village. If a person accused of, say, drunkenness, belongs to a family that's aligned with an opposition party, the sentence would undoubtedly be more brutal. "A lot of factors come into play here, but it is always those without political and financial clout who are subjected to the most ruthless sentences by these courts," says Debanjan Mishra, a teacher of sociology at Calcutta University who has been documenting cases adjudged by shalishi courts over the past couple of years.
The death sentences imposed by the 'shalishi adalats' are usually executed in utmost secrecy and the whole village takes an 'omerta' or oath of silence, thus foiling any effort by the law enforcement machinery to bring members of such kangaroo courts to justice. Even the bodies of the victims remain untraceable. One of the known cases is that of Sheikh Sariul, 29, a van-rickshaw operator of Saramari village of Ratua block in Malda district. Sariul was accused of having an illicit affair with the wife of an affluent farmer of the same village and was summoned to a 'shalishi adalat' on August 27, 2010. The 'adalat', packed with members of the farmer's clan, sentenced Sariul to death. He was beaten to death and his body dumped in the septic tank of the farmer's house. An FIR was lodged and 10 persons arrested, but they are out on bail and the investigations haven't progressed due to lack of evidence. The accused hold that Sariul fled the village just prior to appearing before the 'adalat' and fell into the septic tank while fleeing. The entire village, save for Sariul's family, have stuck to this version and so the police have not been able to make any headway.
In most cases, the 'shalishi adalats' are patronized by politicians and political parties. This is more so in the backward tribal belt where the village headmen and his honchos pass diktats to vote for a particular political party and are, thus, sought after by the parties who do not want to upset or anger them in any way. Very often, the 'shalishi adalats' are used by the party in power to settle political scores over rivals. This particular practice started during the Left Front rule in Bengal. Countless supporters, activists and local level leaders of the Congress and the Trinamool Congress were fined, ostracized and driven out of their villages by these kangaroo courts for real or imagined offences. The Trinamool Congress, after coming to power in Bengal in mid-2011, has not shied away from using these kangaroo courts to subjugate and often snuff out its political rivals.
Nothing legal about it
In 2004, the Left Front government attempted to give a legal sanction to 'shalishi adalats' through the West Bengal Block Level Pre-Litigation Conciliation Board Bill (which came to be better known as the Shalishi Bill). Under this Bill, 'Conciliation Boards' were to be set up in every administrative block for adjudication of minor disputes. But the opposition Congress and Trinamool Congress cried foul and launched a series of agitations against the bill, and the government was ultimately forced to abandon its plans to introduce the Bill in the state assembly. The opposition parties' contention was that the Left (primarily the CPM) would appoint only their own party men to the 'Conciliation Boards' and the Marxists would thus strengthen their grip on power in the rural areas. Nonetheless, the 'shalishi adalats' thrive and now, they serve to strengthen the grip of the Trinamool Congress on rural Bengal.
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Memorandum of Understanding between India and United Arab Emirates on Cooperation in Preventing and Combating of Human Trafficking
The Scheduled Castes and the Scheduled Tribes (Prevention of Atrocities) Amendment Act, 2015
Human Trafficking and Safety & Security of Women discussed
Meharwan Singh Narang... January 27, 2014 At 7:15 am
should we give up and surrender with thought that nothing could be done… if we really want to some change we must change ourselves.. i'm sure that it is almost impossible to trace a single person perfectly atheist. Even a person who claims to be a perfect atheist surrenders at times before the authority of almighty God.. So we must realize that his axe will not sound while attacking. there is a line in guru granth sahib" ik lakh poot sawa lakh nati, ta rawan ghar diya na bati" there is no person to light a lamp in house of one time great emperor Rawana….We have to grill our thoughts.. why we are biased when dealing with different people. when we are acting biased. Either we forget that some one else can behave in a similar way with us or our children, or we do not realize this great reality…no individual on this earth can claim to be a super boss.. there is at least one person stronger than each individual who can dictate and over power our decesions..so when one is not the final authority why he should be biased against or in favor of any one.. we have to work hard to improve our thoughts and also help at least one person like us to improve .. we may prepare a person to be like us just as the hero in film "jai ho" is doing.. the day may come that society is improved with our efforts.. we may say that it is most optimistic approach but what is wrong if we improve our self and try to improve at least one…the education is first step to reduce these instances.. we must realize there is no fault of children of such criminals.. we must try to educate such children,, who in turn will change their parents and the cycle goes on…need of strict legal action against such criminals is the part of a remedy but main aim must be our education our children's educatin
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text:
Q: MySQL Recordset SUM() GROUP BY I have two tables with the following entries:
TABLE 1
tblcategories
id category
1 Architect
2 Engineer
3 Project Manager
TABLE 2
tblpayments
id / categoryid / payment
1 / 1 / 100
2 / 2 / 150
3 / 2 / 50
4 / 1 / 200
5 / 1 / 50
Current my recordset sql looks like this:
SELECT tblcategories.id, tblcategories.category, SUM(tblpayments.payment) AS total
FROM tblcategories, tblpayments
WHERE (tblcategories.id = tblpayments.category)
GROUP BY tblcategories.id
Which gives me the following result:
Record / Id / category / total
1 / 1 / Architect / 350
2 / 2 / Engineer / 200
However, I would like the following result:
Record / Id / category / total
1 / 1 / Architect / 350
2 / 2 / Engineer / 200
3 / 3 / Project Manager / 0
Is this possible?

A: Try this
SELECT cat.id, cat.category, SUM(pay.payment) AS total
FROM tblcategories cat LEFT JOIN tblpayments pay
    ON cat.id = pay.category
GROUP BY cat.id

redpajama_set_name: RedPajamaStackExchange


What does the Daytona 500 have to do with Hometown Hotties from the Sunshine State? It's obvious to us. NASCAR's most prestigious race, which runs Feb. 20, takes place in Florida. Florida is filled with sandy beaches. Sandy beaches are a gathering place for hot, bikini-clad Hometown Hotties from the Sunshine State. Duh.
What does the Daytona 500 have to do with Hometown Hotties from the Sunshine State? It's obvious to us. NASCAR's most prestigious race, which runs Feb. 20, takes place in Florida. Florida is filled with sandy beaches. Sandy beaches are a gathering place for hot, bikini-clad Hometown Hotties. Duh.


text:
Q: react.js and WebRTC RTCPeerConnection.addStream is not an object I want to make a simple video chat on react.js and WebRTC. But in line pc.addStream(localStream) error occurs:

TypeError: Argument 1 of RTCPeerConnection.addStream is not an object.

And I don't understand why I can't see the log in the line:
pc.onicecandidate = (e)=>{
   console.log('onicecandidate');
That is all code:
class App extends Component {
  constructor(props) {
    super(props);
  }
  componentDidUpdate(){
    loadScript("https://webrtc.github.io/adapter/adapter-latest.js");
    let localVideo, remoteVideo, peerConnection, localStream;
    $('#start').on('click', ()=>{ start(true) });

    let id = uuid();
    localVideo = document.getElementById('localVideo');
    remoteVideo = document.getElementById('remoteVideo');

    if(navigator.mediaDevices.getUserMedia) {
       navigator.mediaDevices.getUserMedia( { video:true, audio:true}).then( ( stream )=> {
          localStream = stream;
          localVideo.src = window.URL.createObjectURL(stream);
       }).catch(errorHandler);
   }else{ alert('Your browser does not support getUserMedia API'); }

   function start(isCaller) {
      peerConnection = new RTCPeerConnection( { 'iceServers':  [{'urls': 'stun:stun.services.mozilla.com'}, {'urls': 'stun:stun.l.google.com:19302'},]});
      peerConnection.onicecandidate = ( e ) => {
        if(e.candidate != null) {
           Meteor.call('addMsgRtc', JSON.stringify({'ice': e.candidate, '_id':id}), id);
        }
     };
      peerConnection.onaddstream = ( e )=>{
         remoteVideo.src = window.URL.createObjectURL(e.stream);
      };
      peerConnection.addStream(localStream);
      if(isCaller) {
        peerConnection.createOffer().then(
          createdDescription).catch(errorHandler);
      }
   }
   if (!this.props.loadingRtc) {
      for(let i of this.props.messagesRtc){
        if(!peerConnection) start(false);
        let signal = JSON.parse(i.text);
        if(signal._id == id) return;
        if(signal.sdp) {
             peerConnection.setRemoteDescription(new   RTCSessionDescription(signal.sdp)).then(()=> {
            if(signal.sdp.type == 'offer') {             peerConnection.createAnswer().then(createdDescription).catch(errorHandler);
            }
        }).catch(errorHandler);
      }else if(signal.ice) {
        peerConnection.addIceCandidate(new RTCIceCandidate(signal.ice)).catch(errorHandler);
      }
    }
  }

  function createdDescription(description) {
    peerConnection.setLocalDescription(description).then(()=> {
       Meteor.call('addMsgRtc', JSON.stringify({'sdp':peerConnection.localDescription, '_id':id}), id);
    }).catch(errorHandler);
  }
  function errorHandler(error) { console.log(error); }
}

  }
  render() {
    return (

          <video id="localVideo" autoPlay muted style={{width:"40%"}}></video>
          <video id="remoteVideo" autoPlay style={{width:"40%"}}></video>

    );
  }
}

export default createContainer( ()=> {
  const subscriptionRtc = Meteor.subscribe('rtc');
  const loadingRtc = !subscriptionRtc.ready();
  return {
    loadingRtc:loadingRtc,
    messagesRtc: msgRtc.find().fetch(),
  };
}, App);

A: getUserMedia is an async operation that returns a promise. The .then() that sets the localStream has not been executed at the time when you call pc.addStream.
You might want to move your start() into the .then().
The ontrack event doesn't have a e.stream btw. You probably want to use onaddstream instead. Also please set srcObject = e.stream instead of using URL.createObjectURL.


My colleague James brought to my attention this morning an article saying that online retailers are growing concerned about the impact of Royal Mail's absolute uselessness on their businesses.
The worst postal strike for nearly 20 years is "destroying online companies" and will hit internet Christmas sales because customers can no longer buy confidently over the web, industry executives warned last night.
Really? Customers in general must be slow. Royal Mail lost my confidence a long time ago. In fact, I'm not sure how you'd even notice that there's a strike on, since the normal service is so awful.
I've witnessed a postman actually sign for a 'Signed For' package himself before leaving it outside for my neighbour to collect. If she's lucky.
I've had two packages disappear so far this year, and another take three weeks to reach me from north London. On another occasion, I received a card to tell me that a package hadn't been delivered and was waiting for me at the infamous Mandela Way depot. When I turned up to pick it up, they had nothing for me.
Speaking of the sorting office, if Royal Mail fails to deliver a package, it ends up back there to be collected at the your own inconvenience. Technically, you can call to arrange for redelivery. In practice, they don't answer the phone. The card warns that it takes at least 48 hours for an undelivered package to return to the sorting office. I assumed that this was a cover-your-arse estimate—it's only a couple of miles from my flat to the depot—and foolishly turned up a mere 24 hours later to pick up one parcel. No. It really does take 48 hours for Royal Mail to move a package a distance that I can cycle in under ten minutes.
When you turn up at the sorting office, you realise how backwards the system is. There appears to be no automation at all: finding a parcel is achieved by someone disappearing into a back room and trying to find it.
Even when they're not on strike, they're rubbish. I'm sure that as much blame lies with the management as with the staff, but I find it hard to have any sympathy for any of them.
It's no wonder that, at the depot, they have to work behind toughened glass, and that there's a sign saying that violence against staff will not be tolerated. People get angry for a reason, and the smug, indolent incompetence of the place would make the Dalai Lama see red.
I accept that postal deregulation has been done in a way that disadvantages Royal Mail, hamstringed by its universal service obligations. That doesn't mean that they shouldn't buck their ideas up. Otherwise, they'll drive away their remaining customers.
In the meantime, the smart retailers won't be hurt by postal disruptions: they have already realised that not using Royal Mail is a selling point.


text:
Ejemplo de oraciones
Oraciones con "inconsolable"
Escoge una lengua, luego escriba una palabra abajo para recibir oraciones de ejemplo para esa palabra.
Inconsolable en una oración (en ingles)
The children were inconsolable, and Mr.
Jack was inconsolable at the loss of two who were.
Carney was inconsolable and began to struggle wildly.
Mary, mother of Jesus, is grieving the inconsolable.
I begged his pardon, but the old man was inconsolable.
Janelle was inconsolable, as she had thought of that.
His inconsolable widow continued to keep the wine-shop.
It was a baby boy that I lost and Rami was inconsolable.
The little boy's mother was inconsolable when she saw how.
It was spring when I left the shop and an inconsolable Hag Younes.
I rejoice in our wedding, for it wiped away my inconsolable tears.
Callas said, quite inconsolable, that she felt she now was a widow.
Rose was inconsolable over the marriage, horrified [and] heartbroken.
I wouldn't say that Jake was inconsolable because he was no longer crying.
I'd leave her in peace for the time being, she's inconsolable in her shame.
She was inconsolable and cried often and her depression dragged on for months.
But what she felt was an inconsolable grief over the death of the BlackBerry itself.
She had to pull through, or Aazuria would be inconsolable and he would be devastated.
Emma and Bridget did their best to cheer me up, but I was inconsolable at this point.
Some nasty tongues relate that Lisa went a long way to console the inconsolable lover.
ALL MY FAULT!! Maggie wailed incomprehensibly, as she dissolved into inconsolable tears.
Dandelion was inconsolable to think that he might have stopped Hazel breaking from the ditch.
Tom's mum was utterly inconsolable and probably couldn't have said anything even if she wanted to too.
Inconsolable in his unrelenting melancholy, he leapt into the black hole and was sucked into oblivion.
She screamed and wept with heart-rending sobs when the telegram arrived and was devastated and inconsolable.
She ran as fast as a hare and within seconds had her arms around her small daughter, wailing with inconsolable joy.
He clasped his hands, as though nothing could be a bitterer and more inconsolable grief to him than such a discovery.
The sadness, the inconsolable grief was for Nora, though, not for himself: the unfairness of what had happened to her.
I thought of you often, of course, but it seemed beyond my rights to write to you expressing such inconsolable feelings.
Has, after those first few stunned and inconsolable weeks, spent many more trying to get used to the new order of things.
My brother Taiwit, he was sorry to report, died this past winter, and Simahi was inconsolable, although Mathilde was trying.
Claire had been inconsolable, because she had wanted so badly to honor his wishes, but both rings had been taken by the Snake Man.
The carer was inconsolable, she did not like Michael that much, but she did not hate him and certainly would not wish him any ill.
Their oldest son, Greg, tried to help his father and called upon a common friend who left his work and went to console an inconsolable Roger.
Her husband said their local doctor had been treating her for inconsolable delusions and feared she'd become a danger to both their young daughters.
In the middle of the bustling market, a very old man with an inconsolable expression on his face was pulling chicks out of the pockets of his beggar's coat.
But that he was for ever inconsolable, that he fled from society, or contracted an habitual gloom of temper, or died of a broken heart, must not be depended on--for he did neither.
But that he was for ever inconsolable, that he fled from society, or contracted an habitual gloom of temper, or died of a broken heart, must not be depended on—for he did neither.
But Jai was inconsolable, and May Ling and Siri were still in the vehicle attempting to settle her, when there was a tremendous blinding flash and a deafening explosion from the palace.
She was completely inconsolable with grief and Matt pulled her into a corner holding her tightly as he rocked her like he would've done for one of his own children, if he'd ever had any.
Sinónimos para inconsolable
disconsolate inconsolable
Inconsolable definiciones
1. Sad beyond comforting; incapable of being consoled
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Photos and news of The Grand Tour's first episode filming in Johannesburg, featuring a lion and possibly drunk ex-Top Gear trio.
The Grand Tour is Amazon's new car show, and is hosted by former BBC Top Gear presenters Jeremy Clarkson, Richard Hammond and James May.
The build-up to the premiere of this new show has been hugely anticipated by fans of Top Gear, since last year, when Clarkson, no stranger to controversy, was unceremoniously fired by the BBC last year, for having punched one of the show's producers. His two co-hosts, Hammond and May also left the show after Clarkson's axing, and the trio reunited for a new motoring show on Amazon's subscription service, Amazon Prime.
A few months ago, Clarkson claimed that "we'll be travelling the world hosting each episode in a different country, from a giant tent." New photos seem to confirm this, having them set up a giant tent in Johannesburg.
With the confirmed exit of Chris Evans from the BBC Top Gear, it'll be interesting to see the former Top Gear presenters one-up the show they've seemingly left behind. The trio have left big shoes to fill for Matt LeBlanc and Chris Harris, who will probably be taking up the mantle henceforth.
After being picked up by Amazon, the trio weren't allowed to use the word "Gear" in their show's name, leading them to call it The Grand Tour.
The Grand Tour's theme seems to focus more on the road-trips and exploration, which sets them up for traversing a different country every episode. Confirmed filming locations include America, Germany and their childhood locations of Yorkshire. The new set (tent) itself is smaller but more expeditious; with accompanying decor to fit the mood: numerous hats, posters, giant windows and peregrine carpets.
Most important of all, though, Clarkson, Hammond, and May still appear to be having as much fun as ever.
James forgot to wave, though.
The series is expected to air in Autumn of this year.


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People start a home-based affair pro many uncommon reasons. You may feel as though there's just not enough time in the day to build your brand while still commuting to a job day after day, but don't give up. Starting a home business online takes patience and dedication. I see that girls often "lose their voice" or identity and confidence around middle school and a similar thing can happen with women when they become moms.
For those wonder what benign of choose give blessing Tom Saltlick used on Magnum P.I., they should notice that using a settle is supplementary a determinant of existence and capability than how held dear the concede.
You probably have not thought that giving advice to other people will let you earn money. There's a real sizeable good sized distinction among ink tubes as well as the sort of ink that's present in industrial printing patterns.
46 yr old Court Bailiff or Sheriff (Aus) / Court Selections Officer (NZ ) Malcolm Roten from Bow Island, loves to spend time jewellery, , and texting. Has signed up for a world contiki voyage. Is very thrilled in particular about traveling to Su Nuraxi di Barumini.