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Bachelor Degree International Relations Saint Petersburg - FL
B.A. in International Relations and Global Affairs
Saint Petersburg - FL
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Comments about B.A. in International Relations and Global Affairs - At the institution - Saint Petersburg - FL - Florida
The international relations and global affairs major is designed to provide students with an understanding of the international political and economic factors, relationships, and issues shaping today's global community. It is an interdisciplinary major, but its home discipline is political science.
Students majoring in international relations and global affairs affiliate with the Behavioral Science Collegium and will be associates of the political science faculty. Students majoring in international relations and global affairs will gain competency in international political, economic, and foreign policy analysis, proficiency in a foreign language, and skills in research, writing, and oral communication. Students will also gain practical experience in international relations through their work in their practicum. Students will be prepared to go on to graduate study in international relations, the foreign service, or law. They will also be well prepared for a career in the international non-governmental community, service organizations, interest groups, or journalism.
The major requirements consist of three prerequisite courses: PO 103G Introduction to International Relations, EC 282S Principles of Macroeconomics, and HI 234G Twentieth Century World, plus six core courses distributed across the three core groups listed below. Also required are Political Science Research Methods, two and a half years of a foreign language, the international practicum, the Senior Seminar, and the Senior Comprehensive Exam. Students majoring in international relations and global affairs are also strongly encouraged to spend a semester or at least a winter term abroad. Beyond the three prerequisite courses already listed, a minimum of six core courses are required for the major, with at least two courses taken from each of the following three core groups:
Group A - International Relations Theory and Foreign Policy:
AN 289S Gender: Cross-Cultural Perspective
HI 233G Global History in the Modern World
HI 309G The Cold War and After
IR 340 Geneva and International Organization
IR 341 The Hague and International Law
PO 200S Diplomacy and International Relations
PO 212S U.S. Foreign Policy
PO 222 Political Ideologies
PO 243S Human Rights and International Law
PO 251S The Media and Foreign Policy
PO 315 Theories of War and Peace
PO 341 Ethics and International Relations
PO 343S International Environmental Law
PO 351 National Security Policy
RE 105G Religion in Global History
Group B - Regional Studies Group:
Students must take at least two courses, one each from different regions and one each from different disciplines.
AN 282G East Asian Area Studies
AN 285G Latin American Area Studies
AN 286G Cultures of Sub-Saharan Africa
AN 287G Caribbean Area Studies
EA 201G East Asian Traditions
EA 303G Individual and Society in Chinese Thought
EA 310G Modern China
EA 311G Modern Japan
HI 202H The European Experience
HI 283G Russia: Perestroika to Present
HI 342H The Rise of Russia
HI 343H Modern Russia and the Soviet Union
HI 368H Modern German History
LI 244G Postcolonial Literature
LI 314G Caribbean Literature and Film
LI 334 20th Century European Fiction
PO 211G Inter-American Relations
PO 221S Politics of Revolution & Development
PO 231G East Asian Comparative Politics
PO 252S Middle East Politics
PO 263G North African Politics
PO 311G Latin American Politics
PO 316G Women and Politics Worldwide
PO 321S Comparative European Politics
PO 322S Authoritarian Political Systems
PO 324 East European Politics
PO 333 Japan: Government, Politics, Foreign Policy
PO 335S Government and Politics of China
PO 336S East Asian International Relations
PO 362G MidEast Conflicts and Wars
Group C - International Political Economy Group:
EC 281S Principles of Microeconomics
ECI 375S China: Economic Deveolpment & Reform
EC 385 Comparative Economic Systems
EC 388 Economic Development
EC 480 International Economics: Foreign Exchange
EC 481 International Economics: Trade
PO 232G The Pacific Century
PO 241S International Political Economy
PO 242S The Politics of Defense: Economics and Power
PO 313 Politics of the European Union
PO 342S Hunger, Plenty, and Justice
PO 352G The Globalization Debate
PO 363G Middle East Political Economy
In addition to the three prerequisite courses, the six core courses, PO 260M Political Science Research Methods, the Senior Seminar (IR 410), and the Senior Comprehensive Exam, the major requires the following:
Language Requirement:
At least two and a half years (five semesters) of college level foreign language or the equivalent. More years of language or a second foreign language are strongly encouraged.
International Practicum:
There are three ways to fulfill the requirement:
* An internship in an institution engaged in international affairs within the U.S. or abroad sponsored by a member of the Political Science faculty. An internship contract must be agreed upon and approved by the registrar prior to embarking on the internship.
* Specified Winter Term and Spring-Into-Summer courses led by IRGA faculty. The U.N. Winter Term, IR 340 Geneva and International Organization, and IR 341 The Hague and International Law are examples.
* Semester study abroad programs recognized for credit by the International Education Office and the registrar. ISEP or CIEE organized semester abroad programs are examples. IRGA students have studied in Austria, Spain, The Netherlands, Germany, Hong Kong, China, Thailand, and France. The Eckerd London program, while excellent, does not fulfill the IRGA practicum requirement.
Students work closely with a member of the Political Science faculty (or faculty from other disciplines represented in the major) in arranging for the practicum and are responsible for informing themselves of the available types of practicums, for choosing one that meets their needs, and for fulfilling the terms of the practicum contract in a timely manner.
Students may also minor in international relations and global affairs by completing PO 103G Introduction to International Relations, PO 241S International Political Economy, and four core courses beyond the introductory level which are distributed across each of the three core groups.
Other programs related to International Relations
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Ludwig, Christa krĭs´tə lo͞ot´vĭkh [key], 1928–, German mezzo-soprano, b. Berlin. The daughter of opera singers, she debuted (1946) as Prince Orlofsky in Die Fledermaus at the Frankfurt State Opera and starred at the Vienna State Opera from her debut as Cherubino in The Marriage of Figaro in 1955 until her retirement from singing in 1994. Her first American performance took place in Chicago in 1959, the same year she debuted at New York's Metropolitan Opera. One of the outstanding mezzos of her generation, she had an unusually expressive voice and broad vocal range. Among her signature roles were Dorabella in Così fan tutte, Kundry in Parsifal, the Dyer's Wife in Die Frau ohne Schatten, and the title role in Carmen. Also adept at lieder, Ludwig was a particularly impressive interpreter of Mahler's songs.
See her memoir, In My Own Voice (1999).


419 Norfolk Ln, Homewood, AL.| MLS# 826190 | Richard Jacks UABLIVING.com 205-910-2297 | Birmingham AL Real Estate | Contact us to request more information about our Homes for Sale in the Birmingham AL area.
This beautiful and elegant home, located on one of the most desirable streets of Hollywood, is complete with high-end amenities, spacious rooms, and architectural charm. The renovations include a large wet bar opening into a den with wood beams, a cathedral ceiling, and a gorgeous wood burning fireplace. The master bath is adorned with stone, custom cabinets, and elegant lighting. The large dining room and living room add to the perfect layout for entertaining guests and families. The kitchen features stainless appliances, stone counter tops, and the ideal breakfast nook. The master suite and two bedrooms are on the main level. Three additional bedrooms with a large den/playroom are upstairs. The basement area has been finished to perfection to include a large den/media room, laundry/exercise room, and a collector's wine cellar. With lush landscaping, a large lot, a detached garage apartment, and walking distance to award winning Shades Cahaba Elementary, this is the perfect home!
Driving Directions: Highway 31 North. Right At Old Montgomery Hwy. Right Onto Windsor Drive. Left Onto Norfolk Lane.


A BROTHER WRITES: Assalamu alaikum .
We hope this message finds you in the best of health and is taken in the true spirit of protecting and safeguarding our pure Deenul Islam.
After hearing some alarming reports of fraud in the overseas Qur'bani schemes, I spoke to a few individuals and these are our concerns.
1.1; Haj,Umrah and Zakaat have already become commercialized 'ibaadaat'.
Qur''bani seems to be going down the same route.
1.2; Administrative costs is a very vague term used and abused by organizations to include high salaries, personal fees and other unwarranted costs.
1.3; Prices advertised for qur'bani in Indo-Pak sub-continent and Palestine are not consistent with realities on the ground and reports from people of the respective countries.
1.4; We have unconfirmed reports of Ulema doing qur'bani at low costs in India and then selling the hides to leather manufacturing companies for astronomical amounts and pocketing the money.
If this is true, is it Islamically correct and ethical?
Please put my concerns to rest and give genuine answers to the above as well as solutions to our way forward.
I saw a poster from Jamiat KZN warning people about this issue.
I think its a good step and other Ulema bodies can do the same.
There are frauds fleecing the public in the name of Qur'baani. Year in and year out we have been warning the community about these frauds. Others too have warned the Muslim community.
The frauds are able to flourish because Muslims do not understand the meaning and spirit of Qur'baani. The desire is to get over the ibaadat as cheaply as possible, hence a few rands are doled out to these frauds operating in the community. They trick, trap and rob people with their expensive, glossy pamphlets and posters advertising grandiose qur'baani schemes.
If the vendors are not known, do not accept them as bonafide personnel. Entrust your Qur'baani to known and uprighteous people and organizations. Do not entrust your Qur'baani to even known organizations who utilize Zakaat funds for their 'salaries' and 'expenses'. They are all frauds and crooks who pay themselves lucrative haraam 'salaries' with the funds intended for the suffering masses.
Do not entrust your Qur'baani to foreigners who come to the country on qur'baani excursions. There is one particular villain from Mozambique who operates a vast qur'baani scam. He must have coined millions in the past couple of years duping the stupid and unconcerned masses.
The suggestion of a local "Support Qur'baani Campaign' is un-Islamic. The vast majority of Muslims remains unaffected by the heart-rending plight of the suffering Muslims in other countries. They waste millions and millions of rands on haraam and unnecessary luxuries and nafsaani holidays whilst massive segments of the Ummah are suffering in grinding poverty, live in squalor and grovel in such ignorance which ultimately culminate in the destruction of their Imaan. The little comfort which Qur'baani meat offers them, while paltry and miniscule, nevertheless, is appreciated.
Wealthy Muslims are selfish. Whatever they contribute in Allah's Path is not at all commensurate to the vast wealth Allah Ta'ala has bestowed to them. Even Zakaat is paid as if it is a burdensome fine. People who are supposed to pay millions of rands in Zakaat annually, dole it out in dribs and drabs, and they mostly overlook the avenues where the need is urgent and most needed. While the smattering of Qur'baani meat is not the solution, it nevertheless, is appreciated by those few suffering brothers, sisters and children who receive the luxury of a little meat.


Food Hunter's Guide to Cuisine: Have You Tried Cabot Cheese?
Have You Tried Cabot Cheese?
Calling all cheese lovers, I recently had the opportunity to sample a few varietals of Cabot Cheese blocks; Pepper Jack and the Sharp Light Cheddar. Both had a surprisingly soft smooth texture.
The Pepper Jack had the perfect amount of spice and I must admit most of it was eaten sliced straight from the block, with a few pieces making their way into salads and sandwiches.
The Sharp Light Cheddar had a great sharp flavor and didn't skip on anything other than being half the fat. It boasts some impressive stats: only 70 calories per 1ounce serving, and 4.5 grams of fat.
Founded in 1919, Cabot Creamery is a co-op, owned and operated by its members and dairy farmers located in New England and Upstate New York. They have a vested interest in providing the highest quality dairy products because 100% of their profits go directly to their family farmers. If you haven't tried the "world's best", I highly recommend you find a store near you and pick up one of Cabot's award-winning cheeses.
After all, everything is better with cheese!
This cheese is so good!! I can't eat cheese (gluten & lactose intolerance) but this is both gluten free and lactose free! It is so creamy and smooth. I've used it to make baked macaroni so many times. My favorite is the pepper jack. That is good melted over tortilla chips!!!
I love Cabot cheese. I first tried it at least 25 years ago when we were stationed in New England. Still just as good now as it was then!
I actually haven't tried Cabot cheese, but they sound delicious! I'll have to look for them next time I go grocery shopping!
Yes, they have been around a long time with quality cheese!
Yes, cabot is my FAVORITE.
I love me some Cabot cheese, all of them are divine!
I do love Cabot cheese! I even had some great samples recently at the Food and Wine Conf and met some of their team!
I love Cabot! Try their greek yogurt too - it's the best!
I'm a New England girl so we have Cabot cheeses all around us. I love Pepper Jack.
Nice introduction to the brand. Thanks.
I love their cheese. It`s quality which us foodies dig.
Mmmmm. Cheese makes me happy!
I'm a Cabot fan!! Cheese is one of the best things about living!!


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Historic Site or District
The Old Mill In Pigeon Forge, Tennessee
Handicapp accessible.
Listed on the national register of historic places and just recently has been added to the civil war trails. It has been in continuous operation since 1830.
In the early 1800's, a water-powered gristmill on the banks of the Little Pigeon River became one of the main hubs of activity in the small mountain community of Pigeon Forge, Tennessee. In those days, the mill faithfully produced the meals and flours that were crucial for the day-to-day existence of the Smokies' early settlers. In fact, The Old Mill even furnished electricity for the town until 1935.
One of The Old Mill's most distinctive features is the giant water wheel that harnesses the flow of the Little Pigeon River. Inside the structure, an antiquated yet reliable system of shafts, belts, and pulleys still gets the job done, working to turn the 4600-pound stones and grain elevators.
Weighing one ton each, the massive flint granite stones, called French Buhrs, are only the second set ever used in The Old Mill's 178-year history. When they're in action, the stones convert grain into about 1000 pounds of product each day, six days a week. Resident millers then hand-fill, weigh and tie each bag of stone ground grain.
Products ground at The Old Mill are used in many of the dishes at The Old Mill Restaurantincluding biscuits, corn bread, pancakes, hush puppies, muffins and grits. We also use our own grains for the homemade artisan style breads that are prepared each day at The Old Mill Pottery House Cafe .
The area's heritage is also being preserved through a variety of crafts that are practiced at the nearby shops of The Old Mill Square. Our Pigeon River Potteryhas been home to pottery making for over 50 years, and the best of time-tested recipes are prepared by our confectioners (with decades of experience among them) in The Old Mill Candy Kitchen. The entire Square is a working tribute to the Smokies' pioneer days.
Today, The Old Mill is listed on the National Register of Historic Places, and just as in the 19th century, it's still one of the most popular places in the Smokies and one of the most photographed mills in the country.
US-441 South (Parkway in Pigeon Forge)
Follow signs to Sevierville/Pigeon Forge/Gatlinburg
Turn left at traffic light #7 in Pigeon Forge
Street Address: 175 Old Mill Avenue, Pigeon Forge Tennessee 37868
Time Period Represented
7 days a week. Hours vary seasonally; call 865-428-0771 or visit Old-Mill.com.
Visitor Fees
The Old Mill Rack Card
The Old Mill Restaurant Menu
Pottery House Cafe Menu

redpajama_set_name: RedPajamaCommonCrawl


Brickhouse took the SLU post in July 2015. In that role, Brickhouse oversees all the academic programs, including 10 colleges, as well as research, enrollment, libraries and museums at the university. During her time there, Brickhouse has been instrumental in developing new academic programs, expanding existing programs and making cuts where necessary.
Programs in computer science, software engineering, cybersecurity and strategic intelligence, among others, were created under her leadership. These efforts will contribute to $5.6 million of projected new revenue for fiscal 2019 and beyond, she said. She also discontinued 26 programs, including a technology program that had only one student. The university's most recent annual budget is $850 million and its endowment is $1.15 billion.
Brickhouse also helped expand the INTO SLU program, which helps internationalize the St. Louis campus. The program has prompted a 46 percent annual increase in new international students and will generate $3.5 million in new revenue beginning in fiscal 2020, Brickhouse said.
In addition, she helped lead the $28 million renovation of Macelwane Hall, the university's main biology building, and the design of the new $50 million interdisciplinary science and engineering building. The biology building will open in December, while the university plans to break ground on the interdisciplinary building this fall, Brickhouse said.
Brickhouse will step down as SLU's provost effective Aug. 15, after which she plans to take an academic sabbatical.
Outside the provost role, Brickhouse serves on the board of directors and on a strategic planning committee for the Grand Center Arts District. She also is on a steering committee for the St. Louis Mosaic Project.


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Facebook faces $5B FTC fine, largest ever in tech
On Friday, July 13 members of the FTC voted in favor of $5 billion fine for the social media juggernaut following a 2018 investigation.
Facebook faces $5B FTC fine, largest ever in tech On Friday, July 13 members of the FTC voted in favor of $5 billion fine for the social media juggernaut following a 2018 investigation. Check out this story on ydr.com: https://www.ydr.com/story/news/local/2019/07/13/facebook-faces-5-b-ftc-fine-largest-ever-tech/1726471001/
Barbara Ortutay, The Associated Press Published 8:24 p.m. ET July 13, 2019 | Updated 8:26 p.m. ET July 13, 2019
Yorkers joined the nationwide "Lights for Liberty" vigil to end human detention camps by protesting in front of the York County Prison. York Daily Record
At $5 billion, the fine the FTC is about to levy on Facebook is by far the largest it's given to a technology company, easily eclipsing the second largest, $22 million for Google in 2012.
The long-expected punishment, which Facebook is well prepared for, is unlikely to make a dent in the social media giant's deep pockets. But it will also likely saddle the company with additional restrictions and another lengthy stretch of strict scrutiny.
The Wall Street Journal and other news outlets reported Friday that the FTC has voted to fine Facebook for privacy violations and mishandling user data. Most of them cited an unnamed person familiar with the matter.
Facebook and the FTC declined to comment. The 3-2 vote broke along party lines, with Republicans in support and Democrats in opposition to the settlement, according to the reports.
FILE - In this April 30, 2019, file photo, Facebook CEO Mark Zuckerberg makes the keynote speech at F8, Facebook's developer conference in San Jose, Calif. A Wall Street Journal report says that the FTC has voted this week to approve a fine of about $5 billion for Facebook over privacy violations. The report Friday, July 12, 2019, cites an unnamed person familiar with the matter. (AP Photo/Tony Avelar, File) (Photo: Tony Avelar, AP)
The case now moves to the Justice Department's civil division for review. It's unclear how long the process would take, though it is likely to be approved. A Justice Department spokeswoman declined to comment on the Facebook matter.
For many companies, a $5 billion fine would be crippling. But Facebook is not most companies. It had nearly $56 billion in revenue last year. This year, analysts expect around $69 billion, according to Zacks. As a one-time expense, the company will also be able to exclude the amount from its adjusted earnings results —the profit figure that investors and financial analysts pay attention to.
"This closes a dark chapter and puts it in the rearview mirror with Cambridge Analytica," said Wedbush analyst Daniel Ives. "Investors still had lingering worries that the fine might not be approved. Now, the Street can breathe a little easier."
Facebook has earmarked $3 billion for a potential fine and said in April it was anticipating having to pay up to $5 billion.
But while Wall Street — and likely Facebook executives — may be breathing a little easier, the fine alone has not appeased Facebook critics, including privacy advocates and lawmakers.
"The reported $5 billion penalty is barely a tap on the wrist, not even a slap," said Senator Richard Blumenthal, a Democrat from Connecticut. "Such a financial punishment for a purposeful, blatant illegality is chump change for a company that makes tens of billions of dollars every year."
Related: Breastfeeding mom asked to 'cover up' at Pa. pizzeria. Now she's responding on Facebook
More: 'Punch a guy so hard he poops himself': Police under fire for 'shameful' social media posts
He and others questioned whether the FTC will force Facebook to make any meaningful changes to how it handles user data. This might include limits on what information it collects on people and how it targets ads to them. It's currently unclear what measures the settlement includes beyond the fine.
Privacy advocates have been calling on the FTC to come down on Facebook for a decade, but over that time the company's money, power and Washington influence has only increased.
"Privacy regulation in the U.S. is broken. While large after-the-fact fines matter, what is much more important is strong, clear rules to protect consumers," said Nuala O'Connor, president and CEO of the Center for Democracy and Technology. The CDT is pushing for federal online privacy legislation.
Some have called on the FTC to hold Facebook CEO Mark Zuckerberg personally liable for the privacy violations in some way, but based on the party line vote breakdown, experts said this is not likely.
Marc Rotenberg, president of the nonprofit online privacy advocacy group Electronic Privacy Information Center, said he was "confused" as to why the Democratic commissioners didn't support the settlement and said he suspects, without having seen the actual settlement, that this was due to the Zuckerberg liability question.
"But I thought that was misguided," he said, adding that EPIC instead supports more wholesale limits on how Facebook handles user privacy.
Since the Cambridge Analytica debacle erupted more than a year ago and prompted the FTC investigation, Facebook has vowed to do a better job corralling its users' data. That scandal revealed that a data mining firm affiliated with President Donald Trump's 2016 campaign improperly accessed private information from as many as 87 million Facebook users through a quiz app. At issue was whether Facebook violated a 2011 settlement with the FTC over user privacy.
Other leaky controls have also since come to light. Facebook acknowledged giving big tech companies like Amazon and Yahoo extensive access to users' personal data , in effect exempting them from its usual privacy rules. And it collected call and text logs from phones running Google's Android system in 2015.
SAN JOSE, CALIFORNIA - APRIL 30: The Facebook logo is displayed during the F8 Facebook Developers conference on April 30, 2019 in San Jose, California. Facebook CEO Mark Zuckerberg delivered the opening keynote to the FB Developer conference that runs through May 1. (Photo: Justin Sullivan, Getty Images)
Wall Street appeared unfazed at the prospect of the fine. Facebook's shares closed at $204.87 on Friday and added 24 cents after hours. The stock is up more than 50 percent since the beginning of the year. In fact, Facebook's market value has increased by $64 billion since its April earnings report when it announced how much it was expecting to be fined.
Rep. David Cicilline, a Democrat from Rhode Island, said in a statement that the fine gives Facebook "a Christmas present five months early. It's very disappointing that such an enormously powerful company that engaged in such serious misconduct is getting a slap on the wrist. This fine is a fraction of Facebook's annual revenue."
Cicilline leads the House Judiciary subcommittee on antitrust, which is pursuing a bipartisan investigation of the big tech companies' market dominance.
The fine, however, doesn't spell the end of Facebook's troubles. The company faces a slew of other investigations, both in the U.S. and overseas, that could carry their own fines and, more importantly possible limits to its data collection. This includes nearly a dozen by the Irish Data Protection Commissioner, which oversees privacy regulation in the European Union.
Read or Share this story: https://www.ydr.com/story/news/local/2019/07/13/facebook-faces-5-b-ftc-fine-largest-ever-tech/1726471001/


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redpajama_set_name: RedPajamaGithub


We are on a mission to raise $20,000 this year for Phoenix Children's Hospital. For every family that we help buy or sell a home, we will donate a portion of our income to their much needed research.
Phoenix Children's Hospital has provided hope, healing, and the best healthcare for children since it was born in 1983, and has grown to become one of the largest children's hospitals in the country.
We are on a mission to raise $20,000 this year for Phoenix Children's Hospital. For every family that we help buy or sell a home, we will donate a portion of our income to their much needed research. Can you help us?


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Commission Decision No. 20-M-005/2019: In the Matter of the Proposed Acquisition by GlaxoSmithKline Consumer Healthcare Holdings Ltd. of Pfizer Inc.'s Consumer Healthcare Business
Commission Decision No. 20-M-005/2019:
In the Matter of the Proposed Acquisition by GlaxoSmithKline Consumer Healthcare Holdings Ltd. of Pfizer Inc.'s Consumer Healthcare Business
The transaction involves the proposed acquisition by GlaxoSmithKline Consumer Health Holdings Ltd. ("GSK CH") of Pfizer Inc.'s ("Pfizer") Consumer Healthcare business ("Pfizer CH").
GSK CH, the acquiring entity, is an indirect subsidiary of GSK Plc., the United Kingdom-based multinational pharmaceutical company.
Pfizer CH, the acquired business, is a unit under Pfizer Inc., the US-based multinational corporation under its essential health business segment.
In the Philippines, the proposed transaction will be a pure acquisition of assets, including inventories, stock-in-transit, equipment, contracts, intellectual property, and goodwill, among others.
GSK, the acquiring ultimate parent entity, will issue to Pfizer non-controlling shares that will represent 32 % ownership interest in GSK Consumer Healthcare. Post-transaction, GSK will have 68% ownership and control over GSK CH.
GSK develops, manufactures, and markets a broad range of prescription, vaccine, and consumer healthcare products. GSK is present in the Philippines through Duncan Pharmaceuticals Philippines, Inc. and GlaxoSmithKline Philippines, Inc., both handling its prescription and vaccine products. They are also present in Duncan Consumer Healthcare Philippines, Inc., and GlaxoSmithKline Consumer Healthcare Philippines, Inc. which conduct its consumer healthcare business. SmithKline Beecham Research Limited is dedicated to both prescription and consumer healthcare activities.
Pfizer CH develops, manufactures, and markets non-prescription medicines, vitamins, and nutritional products in five areas: pain management, gastrointestinal health, respiratory, dietary supplements, and personal care. It also markets prescription products that have become over-the-counter.
Download (Commission-Decision-No.-20-M-005-2019_GSKPfizer_27-June-2019.pdf)


The stiff, coarse bristles are designed for use on leather hard greenware. The brush is made with stainless steel wires firmly set in a hardwood handle for a total length of 6 1/2". Use it for subtle textures on large areas of greenware.


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You are here: Home / Human Interest / Humane Society seeing impact of tough economy
Humane Society seeing impact of tough economy
Economic times are tough for many Iowans, but some families are seeing such hardship, they're being forced to take their dogs, cats or other pets to a shelter as they can no longer afford to feed them. Lori Hagey, with the Humane Society of North Central Iowa, says their shelter is seeing only a modest impact from the recession.
"It's a really amazing thing — the last thing people want to give up are their pets," Hagey says. "We've seen some of that, people who are moving and can't keep their animals." She says the shelter in Fort Dodge serves communities in a 60-mile radius and is able to place dozens of pets per month in new, loving homes.
February was a record month for adoptions at the shelter, with 69 animals finding new homes during the month. Hagey says, "Maybe people are thinking about being closer to home and having entertainment from their new dog or cat." The agency is a non-profit that gets no city or state funding — only donations.
She says the shelter is sometimes the last stop and the only stop for people who have to surrender their pets so they can find new homes instead of risking being put to sleep. The Fort Dodge facility does no euthanization, she says, "We find new homes for everybody." The Humane Society of North Central Iowa is hosting a fundraiser in Fort Dodge tonight (Saturday) called, The Fur Ball — Bets For Pets. It features a host of casino-type games, food, a D-J, and silent and live auctions. For information, visit the website: www.fdhumane.com .
Filed Under: Human Interest


After we played bocce ball I went upstairs with my cousin. We played Fortnite, all the families came up to see the room for about an hour. We played Fortnite for a little longer and then went to bed. The next morning we got all geared up to go up to the mountain. Right when we started going up the hill, at the perfect timing we saw their car. They followed right behind us to the top of the mountain. We had to go up three rows of the parking lot, so we had to walk down all the way we came up in ski boots. When we are getting our passes our cousins went to go and get their first run of the day. When we got our passes we waited at the bottom of the hill. They said it was warm enough so we went up to take a run. That was my first run so it was a little hard to turn, but I got it down in the next minute. We went down the same one one or two more times, then we went down one of the steeper ones. The steep one was easy for me. We also went down that one a couple more times. While we were going down that run there were jumps in the middle, so I would do those on the way down.
When we were half way done with our day we went to the lodge to get some chill fries. We ate those and we were all full. When I went to do another run I fell a couple of times because I was so full. When we were done we walked all the way up to the car to pack all of our stuff up. Then we drove all the way back down the mountain. Then, we went to the cousins house we got to see there dog Slide. It wasn't snowing at there hose so we couldn't play in the snow. I slept over at my cousins house and played Fortnite. We did the same thing the next day then went to bed and woke up. We packed our bags and went on a drive all the way to Mammoth.The drive was about three hours, plus we stopped to eat. So that added about 30 minutes. I was so sad because the cousins came a day after us and I wanted to stay with them.
The cousins said they would be at the condo at any minute, so I wanted by the window and when the came I was so exited. Our condo had three bedrooms, two bathrooms, kitchen, and a living room. The master bedroom had a bathroom too. There was snow outside the condo but we never played in the snow because they never wanted to. It was warmer up on this mountain than it was in Reno which was weird. The same time I was staying up there my friend from up the street was up in Mammoth too. We got to see him one night but not for long.


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Beautiful Science Pictures Of Nature
Isn't she beautiful? It's Earth Day. And please feel free to share links to your own favorite satellite images!* See Also: WiSci 2.0: Brandon Keim's Twitter and Del.icio.us feeds; Wired Science on.
Here's a look at the photos that nabbed a final slot in the Natural World & Wildlife category. Here, Nadia Aly from the U.S. captured this fluffy-looking bunch of penguins in an image she dubbed.
Apr 06, 2014 · Sometimes we have to remind ourselves just how awesome Mother Nature is so here are 28 pictures that will do just that. Mother Nature never fails to impress as shown in all these images. We've also recently
Sarah Zielinski is an award-winning science writer and editor. She is a contributing writer in science for Smithsonian.com and blogs at Wild Things, which appears on Science News.
The Earth Science Picture of the Day highlights the diverse processes and phenomena which shape our planet and our lives. EPOD will collect and archive photos, imagery, graphics, and artwork with short explanatory captions and links exemplifying features within the Earth system. The community is invited to contribute digital imagery, short captions and relevant links.
Pretty soon, we are going to run out of resources and mankind will cease to exist. Before that happens, here are some pictures of our magnificent Mother Nature that our future generations might not.
In the NY Times Learning Network lesson Only Skin Deep?A Look at Beauty Around the World, students examine and compare notions of beauty in cultures around the world and explore the connection between what is deemed "beautiful" and cultural history. The article Beauty, by Australia Broacasting Company's Dr. Karl and featured on ABC's Science Online, delves into the relationship between body.
Scientists, professional photographers, and even regular people captured these events in eye-opening pictures that remind us how incredible science really is.
Dutch yacht design firm Sinot recently unveiled its 120-meter (394-ft) concept yacht during the Monaco Yacht Show 2017. Dubbed Nature, the superyacht is designed to push the boundaries of.
Browse the Science & Nature category for available TV programmes to watch on BBC iPlayer.
for summer will be coming once again and so too will the beautiful blooms of begonias. With so much of the Northern Hemisphere being engulfed with the cold of winter, a look at what the promise of.
Scientific illustration is more than just pretty pictures. on Cool Green Science and in any corresponding comments are the personal opinions of the original authors and do not necessarily reflect.
Double Major Computer Science And Economics Tanner Reid Griffis may attend Duke or UGA and major in international affairs. • Jason Williams Hamil plans to attend the U.S. Naval Academy and major in economics. a college and plans to major in. Jan 15, 2013 · Best Answer: read this books if possible before deciding to choose computer science because computer science is
National Geographic stories take you on a journey that's always enlightening, often surprising, and unfailingly fascinating.
Ut Austin Math Office Of Advising Atlanta Botanical Garden Glass Sculpture Inside, mini-golf and car shows are given equal weight to art. garden. What I found was that the world of botanical gardens was much more open and sharing. So, when we decided to do Winterlights in. What Are The Fields Of Computer Science Evolution Of Samurai Armor Let us take
From Iguazu Falls to Lençóis Maranhenses National Park, there are some breathtakingly beautiful places in Brazil. Ilha da Queimada Grande, located about 90 miles off the São Paulo coast, seems.
dark nature. Fascinatingly, Evans' science experiments in the name of photography are often no bigger than a couple of inches in size. His resulting photos masterfully capture a distorted sense of.
Compounds With The Same Chemical Formulas But Different Molecular Structures Are Called Revision notes on writing equations in chemistry, how to balance chemical equations, how to read and write formulae, word equations, balancing symbol equations, how to write and balance ionic equations, how to work out a formula from valencies, how to work out formula from the charges on the ions, help when revising for AQA GCSE
Jun 28, 2018 · Owls' diets, crab parasites, devious fish and childhood memories – they are all themes and images captured by scientists and artists. The 17 images.
Who knew that cancer, so terrifying, could be so weirdly beautiful. with some really cool photos." [Photos: When science emerges as art] They aren't exactly snapshots of the Grand Canyon. They.
Science and art are complementary disciplines. He is on the Scientific Advisory Board for the Future of Life Institute. His new book is titled A Beautiful Question: Finding Nature's Deep Design. 27.
SAN RAMON, CA — Patch reader Alex Sorokorensky shared this beautiful photo recently taken in Bishop Ranch. Cell phones.
Throughout history, people have found ways to permanently "fix" color to create lasting images of the most exquisite beauty.
May 20, 2019 · National parks contain many of our nation's most treasured landscapes, from the majestic mountain ranges of Alaska to the vast prairies of the Everglades. Learn about the natural resources in parks, from the rocks under our feet to the sky overhead and everything in between. Discover the issues that.
May 20, 2019 · National parks contain many of our nation's most treasured landscapes, from the majestic mountain ranges of Alaska to the vast prairies of the Everglades. Learn about the natural resources in parks, from the rocks under our feet to the sky overhead and everything in.
That creates an opportunity for some pretty stunning photos. These are some of the most striking science and nature images we encountered in 2017. Some are news photos shot this year, while others.
If You Have A Set Of Data How Can You Extract A Mathematical Relationship Between Variables If you suspect that three variables may be linked, you can control for one to test for correlations between the other two. Effectively, you adjust the statistical value of the control to be constant, and test whether there is still a relationship between the other two variables. Jordan Ellenberg's "How Not to Be Wrong: The
Though almost everyone in the field has the best of intentions, science is still a human endeavor, and it is not immune to our shortcomings or our self-interested nature. However. with a stern.
But make no mistake, nature can also be utterly brutal. This doesn't mean it can't also be beautiful at the same time, so take a look at some of the most morbid but stunning images of nature we've.
Images were acquired with an inverted fluorescence microscope (Olympus IX-70; Olympus Life Science Europe GmbH, Hamburg,
Abbey's "Desert Solitaire" is one of the most accurate depictions of nature I have ever read. Or drive through if you are.
Double Arch is shown here. (Credit: Linda & Dr. Dick Buscher) The natural arch treasures found in this region of the American Southwest are a vibrant collection of nature's best creations. The.
These images originally appeared on bioGraphic, an online magazine about science and sustainability and the official.
Photograph: /British Library Beautiful Science: Picturing Data. it merges modern digital displays with historic texts and images. Facebook Twitter Pinterest Perpetual Ocean: Goddard Space Flight.
Explore the huge range of fun science pictures, images, photos, sketches and diagrams available for free use here at science kids. There are hundreds of quality images covering popular subjects such as animals, chemistry, space, technology, biology, nature,
Ap Chemistry Chemical Foundations Test K12 Quizlet makes simple learning tools that let you study anything. Start learning today with flashcards, games and learning tools — all for free. This catalog is an official publication of Miller-Motte College and is subject to revision at any time. The school reserves the right to change, withdraw, or supplement this catalog as it deems
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Q: Can I use a plural noun before "on of the"? Is it correct to use a plural noun before "one of the" and in the following sentence should I use "are" or "would be"? if the sentence is incorrect please let me know the correct version.
Participating in extracurricular activities such as sport events and being a proactive student to promote my university in terms of attending conferences and meetings to talk about the features of my university are(or would be) one of my favorite activities.

A: No, you should not use plurals with "one of".
Instead you could say:

A and B are two of my favorite things.
A and B are some of my favorite things.

There can be exceptions to the above rule when two or more things are treated collectively as one group. For example:

Fish and chips is one of my favorite foods.

As for "are" vs "would be", that depends on your intended meaning. "Are" is the present tense, while "would be" is a conditional. If you do not need to indicate any uncertainty or hypothetical context, then simply use "are".

redpajama_set_name: RedPajamaStackExchange


Pest Posts Archive - Applied Bio-nomics Ltd.
For some time now, we have been publishing and updating our crop recommendations annually. However, many pests and their biological controls behave in a similar way across multiple crops and in a variety of growing conditions. These pest control recommendations are an attempt to simplify and streamline the information we provide to you.


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How did your season starts in America go and were you pleased with results?
Gabby: My season started off great… I started with a win in the first UCI race of the season, which always feels awesome and rewarding. I have had seven podiums so far this season. I would say my best races so far have been at the Cycle Smart International and the Manitoba GP in Canada - I felt strong and in control in both races.
It was always going to be a different season for myself and Jeremy as we had the added stress and pressure of running our own team - managing ourselves and all the logistics and everything else that comes along with that. When you get great results it feels all the more better because you know all the hard work that goes into making it happen.
Jeremy: The season has been up and down for me, but generally better than previous seasons. I have had my best results in the biggest races this season. Third at the Trek CXC race early in the season and 5th in the Louisville Derby Cup race – there have been some great races.
How were the early season US courses – much different to Europe?
Gabby: The early US cyclocross races tend to be very dry and dusty. The weather is normally very summer-like right up until November time. The races are often very fast and packed with corners - which means much more group racing and tactics!
Jeremy: They are so much faster than a lot of the European courses. "Dirt Crits" are basically what they are. Fast and not super technical, allowing for larger groups to contest the win. They are still very difficult, but in a different way to the European races.
NB The Durrin's final race weekend in America - Jingle Cross in Iowa City - was held in very cold and snowy conditions as you can see from the excellent Andy Bokanev photographs.
Did your US race calendar involve a lot of travelling in the big, black Neon Velo camper?
Gabby: That is one of the big differences between US and Euro racing - the fact that in the US races are not generally just a couple of hours apart from each other - you have to fly to them. It's definitely harder logistically. We are lucky that Jeremy and I fly to the far races and we have a driver to drive the NVCT bus to the races with all the bikes. That makes a big difference being able to fly in and out of a race and not have to spend hours travelling on the road.
Jeremy: We have done a little bit of road tripping in the camper, but mostly our driver has been taking care of the long haul and we fly to the destinations. The most recent road trip was from Louisville to Iowa City where I took advantage of the time in the RV and rode the trainer for 1.5 hours. It's actually quite entertaining, because of the speed the RV is traveling and you can actually look around out of the windows!
When did you arrive in Europe and what are transatlantic logistics like?
Jeremy: We arrived on November 17th. The logistics are quite hectic. We flew home from Iowa very early Sunday morning to go home and pack our bikes up and then I fly out very early morning and arrive in London around 10pm and collect our team car and check into the hotel. Gabby flies in the evening time and has an overnight flight. It allows me to get the car and build some bikes before picking Gabby up from the airport and heading straight to Koksijde through the Euro tunnel.
Is there anything you like or dislike about Koksijde and has Jeremy raced there before?
Gabby: Koksijde is a tough race for sure! Every year I pre-ride the course and think 'Wow - how am I ever going to race this?' It hurts your legs so bad. There is lots of running and navigating the sand can be very hard. However having said that, I have had some of my best World Cup races on this course. My best is 9th so I always look forward to this race in a funny way! One of my strengths is running so that is another reason it suits me.
Jeremy: I have never raced this World Cup (Koksijde) before. I'm really looking forward to the challenges that come with a sand race. I have been practicing my running and sand riding, but I have a feeling that nothing can compare to what the actual race will be like.
What excites you about the World Cup coming to Milton Keynes?
Gabby: I'm very excited for the Milton Keynes World Cup. It will definitely feel like a home race and it is huge that the UK is hosting a World Cup. The British women have been the number one ranked nation in cyclocross for three seasons now so it is awesome that our country gets to host.
It's awesome that all my family and friends can come and watch me race a World Cup in the UK. It's a great opportunity, having the support of a home crowd always feels amazing. There is something special about a 'home race' - it is so inspiring.
Jeremy: I'm also excited to race in the UK because its basically my 'second home' now. Gabby's family lives not too far from the World Cup venue and that will allow us to have a lot more home comforts leading up to the race. Cycling is booming in the UK right now and I am excited to see how it all comes together with one of the biggest races coming to a new country!
We also have a film profile of the couple from Behind the Barriers TV here.
Read all our coverage leading up to the Milton Keynes World Cup here.


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Outcome of young adults with chronic myeloid leukemia treated with upfront imatinib: A single institutional experience
Govind K Babu, Aditi Thanky, Linu Abraham Jacob, MC Suresh Babu, Loknatha Dasappa, Sandip Ganguly
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka, India
Sandip Ganguly
Department of Medical Oncology, Kidwai Memorial Institute of Oncology, Bengaluru, Karnataka
Background: Young adult patients with malignancy are a distinct group of the population. In addition to their ailment, psychosocial issues including fertility issues should be addressed. Chronic myeloid leukemia (CML) is a disease of the elderly population. The outcome with imatinib in young population is not known. Aim: To study the clinical profile and outcome of young patients newly diagnosed with CML on imatinib and to compare with those of elderly population in a tertiary cancer center. Materials and Methods: 369 patients with newly diagnosed CML were included in the study. Patients belonging to the age group of 20–39 years were used as the study group and those who were more than 40 years were used as controls. Both the groups were treated with imatinib. They were followed up for a period of 3 years. Milestones in terms of achieving hematological, cytogenetic and molecular responses were noted. Toxicity profile of the imatinib and the compliance of the patients were also recorded. Results: A total of 173 patients were in the study group and 196 patients were in the control group. Rates of achieving a hematological response at 3 months (94.2% vs. 93%), the complete cytogenetic response at 12 months (68% vs. 61%) and major molecular response at 18 months (72.2% vs. 67.6%) were among the study group and control group, respectively. None of them were statistically significant. Three years event free survival among the study group and the control group was (85.2% vs. 83.4%) respectively; however, the difference did not reach statistical significant value. Conclusion: This study shows that the outcome of young adults with CML is comparable to those of the elderly people with imatinib both in terms of response rates and survival.
Keywords: Chronic myeloid leukemia, imatinib, pregnancy, young adults
Babu GK, Thanky A, Jacob LA, Suresh Babu M C, Dasappa L, Ganguly S. Outcome of young adults with chronic myeloid leukemia treated with upfront imatinib: A single institutional experience. J Appl Hematol 2015;6:157-61
Babu GK, Thanky A, Jacob LA, Suresh Babu M C, Dasappa L, Ganguly S. Outcome of young adults with chronic myeloid leukemia treated with upfront imatinib: A single institutional experience. J Appl Hematol [serial online] 2015 [cited 2023 Jan 26];6:157-61. Available from: https://www.jahjournal.org/text.asp?2015/6/4/157/171987
Chronic myeloid leukemia (CML) is a myeloproliferative disease with a characteristic cytogenetic abnormality. The cytogenetic characteristic is the reciprocal translocation between the long arms of chromosome 9 and 22 leading to the formation of the fusion protein BCR-ABL with a constitutive tyrosine kinase activity.[1] This leads to the transformation of CML cells which are a clonal expansion of hematopoietic cells carrying this unique cytogenetic abnormality. Age group for adolescents and young adults has been defined by National Comprehensive Cancer Guidelines to be 15–39 years. CML is a disease of elderly with a median age of being around 67 years.[2] However in India, the median age at diagnosis of CML is 38–40 years.[3] Reports of imatinib on children and adolescents have been reported.[4] However, clinical profile and treatment outcome of the disease in young adults are sparse in the literature. As far as our knowledge goes, this type of study has not been done in India. Hence, this study has been planned to see the outcome of the young population of CML with imatinib.
Newly diagnosed patients with CML who were registered in our institution between 2010 and 2011 were enrolled in the study. Patients were followed up for a total duration of 3 years. Young adults were defined to be in the age group of 20–39 years.[5] Patients aged more than 40 years were used as controls. Both the groups were included in the study after obtaining written informed consent. Spleen size, total count, basophil and eosinophil counts, platelet count, cytogenetic abnormalities, and reverse transcription-polymerase chain reaction (RT-PCR) for BCR-ABL were documented at baseline. Cytogenetic analysis was performed by karyotyping at baseline in all patients using the International System for Human Cytogenetic Nomenclature (ISCN 2009). CML-chronic phase (CP) and CML-accelerated phase (AP) were defined according to WHO criteria. All patients were started on imatinib and were monitored for tolerability and adverse effects during treatment. Patients were followed up at regular intervals for response assessment. Response assessment was done according to ELN 2009 recommendations on the management of patients with CML. Hemograms were done every month to look for hematological response. None of the patients received second generation tyrosine kinase inhibitors (TKIs) or underwent allogeneic stem cell transplant due to financial constraints. A complete hematologic response was defined as a white blood cell count of <10 ×109/L, a platelet count of <450 ×109/L, no immature cells (blasts, promyelocytes, or myelocytes) in the peripheral blood, and the disappearance of all signs and symptoms related to leukemia (including palpable splenomegaly). Cytogenetic response was assessed by doing bone marrow karyotyping study every 6 months until patients achieved a CCyR and thereafter annually. Cytogenetic response was defined as: Complete (CCyR), 0% Ph-positive metaphases; partial (PCyR), 1–35% Ph-positive metaphases; major (MCyR), 0–35% Ph-positive metaphases; minor, 36–65% Ph-positive metaphases; minimal, 66–95% Ph-positive metaphases; or no response, >95% Ph-positive metaphases.[5] Molecular response was observed by doing RT-PCR study for BCR-ABL fusion protein every 6 months till achievement of major molecular response (MMR) and then yearly. MMR was defined if the BCR-ABL/ABL ratio of ≤0.10% or less.[6] Patients were explained about the potential risk of imatinib to the fetus if they would have conceived on imatinib. Options of alternative therapy like interferon alfa were also given. It was up to the patient to decide about the continuation of imatinib, and they were allowed to do that after obtaining written informed consent. Drug was withheld if the patients developed neutropenia (<1000/cumm) or thrombocytopenia (<50,000/cumm) till recovery of counts.
Events were defined as progression of disease and any loss of previously achieved hematological response, cytogenetic response or molecular response. Progression was defined as progression to accelerated and blast crisis of CML including death. AP was defined by the presence of at least 10% blasts in the blood or bone marrow, clonal cytogenetic evolution, at least 20% peripheral basophils, or thrombocytopenia or thrombocytosis unrelated to treatment. Progression to blast-phase CML was defined by the presence of at least 20% blasts in the blood or bone marrow or extramedullary involvement.[7]
Statistical analysis was performed by SPSS version 21 IBM. Kaplan–Meir graph was used to depict the 3 years event free survival (EFS) among the study and the control group.
A total of 369 patients with CML who were treated in our institute during the study period was included in the study. 173 patients belonged to the age group of 20–39 years and were included in the study group. 196 patients aged ≥40 years were used as controls. Baseline characteristics of the patients are shown in [Table 1]. In the study group, 160 patients (92.4%) presented in CP of the disease and 13 patients (7.6%) presented in the AP. Patients were followed up for a median period of 3 years. Imatinib was started at a dose of 400 mg/day for patients in CP, and it was 600 mg/day for those in the AP.
Table 1: Baseline characteristics
Comparison of achievement of milestones in the study group and the control group has been depicted in [Table 2]. Toxicity of the drug was assessed in the study as shown in [Table 3]. Nonhematological toxicity was common than hematological ones. Nonhematological toxicity was more common during the initial phases of treatment. The most common nonhematological toxicities were musculoskeletal including myalgia and arthralgia and hypopigmentation of skin. Among the hematological toxicity, most common were transient myelosuppression and thrombocytopenia. They were easily reversible with temporary cessation of drugs. Compliance of the patients was noted. The rates of noncompliance were higher among the study population which was 6% compared to 4% in the control group. Eight patients from the study group gained parenthood during the study period. Three male patients and five female patients were on imatinib at the time of confirmation of pregnancy. All female patients continued on imatinib except one who was willing to take interferon alfa during the gestational period. All eight pregnancies were uneventful and there were no congenital abnormalities in the children. None of the patients in our study died during the study period. Hence, the overall survival was 100%. The estimated 3 years EFS rate was 85.2% in the study group compared to 83.4% in control group as shown in [Figure 1] (P = 0.1).
Table 2: Comparison of response rate between study and control population
Table 3: Toxicity profile of the patients
Figure 1: Kaplan–Meir graph showing the event free survival among the two study groups
Advent of TKIs has led to a dramatic improvement outcome in CML.[8] CML is a disease of the elderly most commonly presenting in sixth decade. However, recent studies have demonstrated the median age to be 45–55 years.[9] In India, the median age of CML falls in the fourth decade. Reasons for this early incidence of CML are not fully known. Because of the perception that CML is a disease of the elderly, prognostic scoring systems considered age as an important risk factor. Reasons for considering age were due to the poor tolerance of elderly individuals to interferons and limited facility for allogeneic stem cell transplant. Both Sokal and EURO score have determined age >40 years as a risk factor.[10],[11],[12] Hence, applying this score to individuals <40 years may erroneously lead them into the low risk group. Recently, EUTOS score has been proposed as a new scoring system in CML which does not include age as a risk factor.[13]
There are very few reports in literature about the natural history of CML in young population. Pemmaraju et al. have described outcome of CML in adolescents and young adults treated with upfront TKIs. The age of the study population was defined as 15–29 years. In their study, 13% of the patient population belonged to the study group. In that study, the percentage of patients achieving CCyR among the study group and control group was 84% and 93%, while that for MMR was 75% and 86% and both the difference being statistically significant.[14] In contrast, in our study, the rates of achieving CCyR among the study and control group was 68% and 61%, while that of MMR was 72.2% and 67.6%, respectively and the difference was not significant. The lower rates of achieving milestones can be explained by the fact that only imatinib was used in our study compared to usage of all three TKIs in the other one. The increased rates in the study group compared to control group was also a different from that of the one done by Pemmaraju et al. This can be attributed either due to lesser number of patients in the study group or due to adherence or availability of the drugs.
Adolescents and young adults constitute a distinct patient population to the treating oncologist as they have unique clinical characteristics and psychosocial issues. Young adults have a unique drug distribution and body metabolism of drugs. Though studies regarding pharmaceutical effect of imatinib with age have not shown any significant correlation, analyses have revealed that bodyweight and sex can influence the steady state of drugs,[15],[16] which in turn may influence drug metabolism. However, their effect on clinical outcome is not clear because of the heterogeneity of the population.[17]
CML is a chronic disease which requires long (indefinite) period of drug intake. Proper adherence is required for the successful treatment of CML. Adherence to treatment is a difficult proposition for young adults. In this population, nonadherence to treatment has been reported to be more than their younger or older counterparts having the same disease and taking the same treatment protocol.[18] In our study, reports of nonadherence were higher in the study population. It was assessed by noting the interval of visit to the hospital to get the medicines. Hence, in clinical practice measures should be taken to check the compliance for drug intake.
Another important issue in CML among young adults is the issue of fertility. Reports have suggested that there may be poor gonadal functions while they are on imatinib.[19] Effects of imatinib on teratogenicity are not convincingly clear. The outcomes of pregnancy on patients taking imatinib are diverse. Though there are reports of normal pregnancy on imatinib, reports of spontaneous abortion, and congenital malformation of neonates have been reported.[20],[21] The common congenital malformations are meningocele, hypospadiasis, and hypoplasia of frontal and parietal bones. Discontinuation of drugs during pregnancy can be an option. Studies are there to evaluate discontinuation of imatinib after a patient achieved complete molecular response. Around 40% patients remained in molecular remission in spite of not taking the drug.[22],[23] Low risk sokal score is considered as an independent prognostic factor for molecular relapse. However, this clinical practice has not been validated outside clinical trials. Hence, the patients were continued on imatinib during pregnancy.
Thus, management of young adults with CML can be extrapolated on the basis of its experience in elderly population. Validation of a proper prognostic system in CML is still not clear because different studies have shown variable results in terms of superiority over one another. Tailoring of therapy according to prognostic score is still not clear. In addition to treatment, compliance should be monitored and family and societal support should be ensured. Proper counseling and guidance regarding psychosocial issues is a must for optimal outcome in this patient population.
There are no conflicts of interest
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Pemmaraju N, Kantarjian H, Shan J, Jabbour E, Quintas-Cardama A, Verstovsek S, et al. Analysis of outcomes in adolescents and young adults with chronic myelogenous leukemia treated with upfront tyrosine kinase inhibitor therapy. Haematologica 2012;97:1029-35.
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Zamah AM, Mauro MJ, Druker BJ, Oktay K, Egorin MJ, Cedars MI, et al. Will imatinib compromise reproductive capacity? Oncologist 2011;16:1422-7.
Ault P, Kantarjian H, O'Brien S, Faderl S, Beran M, Rios MB, et al. Pregnancy among patients with chronic myeloid leukemia treated with imatinib. J Clin Oncol 2006;24:1204-8.
Ross DM, Branford S, Seymour JF, Schwarer AP, Arthur C, Yeung DT, et al. Safety and efficacy of imatinib cessation for CML patients with stable undetectable minimal residual disease: Results from the TWISTER study. Blood 2013;122:515-22.
Mahon FX, Réa D, Guilhot J, Guilhot F, Huguet F, Nicolini F, et al. Discontinuation of imatinib in patients with chronic myeloid leukaemia who have maintained complete molecular remission for at least 2 years: The prospective, multicentre Stop Imatinib (STIM) trial. Lancet Oncol 2010;11:1029-35.
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Hematology, Transfusion and Cell Therapy. 2020;
2 Pregnancy outcomes of women whom spouse fathered children after tyrosine kinase inhibitor therapy for chronic myeloid leukemia: A systematic review
Zsolt Szakács,Péter Jeno Hegyi,Nelli Farkas,Péter Hegyi,Márta Balaskó,Adrienn Eros,Szabina Szujó,Judit Pammer,Bernadett Mosdósi,Mária Simon,Arnold Nagy,Gabriella Für,Alizadeh Hussain,Ashkan Emadi
Babu GK
Thanky A
Jacob LA
Suresh Babu M C
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Home » Australian searchers end hunt for missing Malaysia aircraft
Today's NewsTransportation Safety
Australian searchers end hunt for missing Malaysia aircraft
KEYWORDS accident investigation / aviation safety
Authorities in Australia have closed the book on a commercial aircraft that went missing three years ago and has never been found.
In a final report published yesterday, the Australian Transport Safety Bureau (ATSB) said it would be impossible to determine the cause of the disappearance of Malaysia Airlines flight MH370 on March 8, 2014, without finding the remains of the aircraft.
"We...deeply regret that we have not been able to locate the aircraft, nor those 239 souls on board that remain missing," said the report's authors.
The plane vanished on a flight from Kuala Lumpur to Beijing with 239 people on board. Despite a protracted series of both above and below sea level searches, no debris from MH370 was every found. The report said the underwater searches "eliminated most of the high probability areas," but they did not enable investigators to pinpoint the location of the wreckage.
China and Malaysia joined Australia in the inquiry into what has become one of the most significant aviation mysteries in history.
The plane is believed to have gone off course and crashed off the coast of Western Australia.
"It is almost inconceivable and certainly societally unacceptable in the modern aviation era ... for a large commercial aircraft to be missing and for the world not to know with certainty what became of the aircraft and those on board," said the ATSB.
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Many employees are worried about the rise in robotics and automation, afraid that these types of technology will displace the workforce. In reality, it's just changing what skills employees need.
A common narrative around automation is that machines will replace the human workforce in the near future, but this is an inaccurate—or, at the very least, incomplete—picture of the human job outlook. While automation reduces the need for professionals to perform some manual tasks, technological advances will also create new opportunities for people to work alongside machines.
According to the World Economic Forum's Future of Jobs Report 2018, machines will perform 42 percent of total tasks hours by the year 2022, a 13-percent increase from 2018. This is a noticeable uptick, but these findings correspond to shifting skills demand across multiple industries. For example, skills like critical thinking and analysis, complex problem solving, and emotional intelligence will continue to grow in prominence by 2022, while competencies like manual dexterity and technology installation and maintenance will continue to decline in importance.
Some professionals don't even have to wait that long to see this shift. A 2018 report from the Association of American Colleges & Universities found that "employers overwhelmingly endorse broad learning and cross-cutting skills as the best preparation for long-term career success." In other words, executives and hiring managers look for candidates who are proficient in skills like communication, collaboration, and critical thinking. Reports like these indicate that to survive and thrive in an increasingly automated world, workers need to rely on what makes them uniquely human—soft skills. When you consider that nearly half of all knowledge gained in the first year of a four-year technical degree is outdated by the time students graduate, it's not hard to see why.
Prior to becoming the CEO at Bongo, Josh Kamrath was an investor and account manager at several other leading software companies. As a thought leader in the edtech space for the past six years, Josh speaks at major education, assessment, and talent development conferences every year.


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Twitter gets updated. Now it's available for Windows 10 Mobile devices!
- Find the best of Twitter in an instant with Moments. Follow top stories through immersive pics, clips and conversations. Get insights and perspectives you won't find anywhere else.
- Group Direct Messages: Have a private conversation with a group of your favorite people.
- Quote Tweet makes it easier to add your own comments to other people's Tweets.
- Now you can shoot, edit and share video on Twitter. Capture life from your perspective, and share it with a global audience — instantly.
- Conversations have a new look! They're easier to find and fun to join.
Finally! Love it! It took at least 4 Years for a working app!
Someone should obliterate that brat Diego F. from here. I only see him lying and cursing people on comments.
Hh finally, is this a joke windows 10 is just big joke! New day=new problem in my windows phone, today i can say i hate windows 10 i hate in my booms. They say new feautres is coming oh yeah big update! What? What i can do with new feautres if basic thing not working? I want to say; if u want to whestel ur time buy windows 10 phone.
I got no update (Im on fast ring) so far. Whats the build number??
WP10 worthy update, kudos to Twitter!
Nofications seems broken, anyone having same issue?
This update it is so amazing, twitter shup up to everyone!
Ahora permitan ponerle fondo blanco. Y sigan actualizando mas seguido.
They must fix the notification issue as fast as possible. What's the point of twitter without real time, always ON notifications?
It doesn't show me moments. It shows me trending tweets instead..why?
OMG!what an update.really love it.
Finalmente!! Cansei de tet só no PC o Twitter para Windows 10.
The Store doesn't have the updated screenshots though.
Does anyone else have the problem on desktop that it seems like the app has not been registered properly? It's listed in start menu, but if I type "twitt", it doesn't find the Twitter app. Also, I can't select the Twitter app for lock screen info.
Yet not designed for W10 but it's great!
I hope all apps are into effort like these..
Breath, breath, breathhhhh. Windows mobile still alive!
BIGGGGGGG, this is BIGGGGG, after many bad news last days, I just have to say "THANKS TWITTER"
Oh my gooodies what an update, even with accent color!!!!!


Microsoft Tuesday revealed pricing for its forthcoming hosted business productivity services and unveiled its channel model for allowing partners to resell those services. However, while the company painted a rosy picture for the partner opportunity around its evolving software-plus-services business model, not all of its partners were thrilled with the idea of Microsoft competing with them in that market.
As part of its plan to transition from providing only on-premises software to a combination of software and hosted services, Microsoft early next year will begin offering a hosted business productivity suite that includes Exchange Online, Office SharePoint Online, Office Communications Online and Office Live Meeting for US$15 per user, per month.
The company unveiled the pricing for its forthcoming hosted services at its Worldwide Partner Conference (WPC) in Houston this week. Microsoft's hosted services partners already can offer customers this package through Microsoft's Hosted Messaging and Collaboration 4.5, which the company released two weeks ago.
Individually, Microsoft will be selling hosted Exchange Online for $10 per user, per month; SharePoint Online for $7.25 per user, per month; Office Communications Online for $2.50 per user, per month; and Office Live Meeting Online for $4.50 per user, per month.
This means if customers buy the entire suite, they are getting a 38 percent discount than if they buy the products individually, said Microsoft Director of Online Services Eron Kelly on a conference call Tuesday.
On top of its hosted business productivity services, Microsoft also introduced two "deskless" offerings that allow companies to offer workers who don't necessarily sit in front of PCs but still need access to e-mail and internal company Web sites access to those online services. Exchange Online Deskless Worker and SharePoint Online Deskless Worker will be available for $3 per user, per month early next year.
Microsoft's is facing competitive pressure from Google, which is offering similar hosted services to business customers, and so had to price its hosted services competitively.
But this also puts them in direct competition with hosted-services partners that have been offering their own hosted services using Microsoft software infrastructure. And its traditional reseller partners also won't see the kind of margins in reselling services that they've seen with reselling software licensed in the traditional per-CPU way, they said.
One former Microsoft partner who asked not to be named suspects that Microsoft knew it would cause its hosting partners grief if it went ahead and offered its own hosted services, but thought it was a small price to pay compared to losing that business to Google.
"I think they looked at one hand [and] they looked at Google, which was causing all kinds of headaches and is tough competition, and looked at a set of long-term hosted Exchange partners and thought, 'Who can we afford to [tick] off more?' " he said. "It's obvious what they chose."
Danny Essner, director of marketing for Microsoft hosted Exchange partner Intermedia, said Microsoft's pricing for its hosted services is "very aggressive" and will force the company's hosted partners to "move up the stack to preserve profit margins."
For example, Intermedia can offer mobile e-mail support for BlackBerry users on a hosted version of Exchange, while Microsoft does not offer this service.
However, even if hosted partners may have to work harder now that Microsoft is competing with them, Essner said the fact that Microsoft is "bringing market education and market awareness" to the hosted services space is a good thing for anyone providing these services.
Indeed, Scott Gode, vice president of marketing for another Microsoft partner, Azaleos -- which offers managed services for Exchange customers that install the software on premises -- said many customers prefer to have their proprietary e-mail hosted on site rather than farm that out to a third party.
"There is still a huge percentage of customers that will run it locally and want to run it locally because of security concerns," he said of Exchange.
But even if Microsoft knew some partners might be unhappy with their new, yet necessary, business model, the company certainly doesn't want to cut its loyal partner channel out of its services strategy, which is where it's new customer-referral model around hosted services comes into play.
Partners can offer Microsoft's hosted business productivity services to customers and receive 12 percent per user, per month, up front for a first-year contract, and 6 percent per user, per month, of the ongoing subscription fee, the company said. So in the first year, resellers of hosted services will receive 18 percent margins on the subscription value, and 6 percent for subsequent years, Microsoft's Kelly said.
Microsoft also is encouraging partners to add value to the sale by doing what they have always done best, offering integration, consulting and management services on top of any vendor products their customers buy, whether hosted or on-premise.
"Not only are the upfront fees fair for the referral, but the follow-on fees allow [partners] to build a rich annuity stream," she said.
However, Watson did acknowledge that some partners are worried that by reselling Microsoft's hosted services in a referral program, they will be doing a lot of the legwork to secure customers and lose control by merely turning them over to Microsoft, since the company handles the support and billing for the services.
She attributed this to fear among partners that they will not be part of the ongoing relationship with the customer, which is not the case.
"The concern you've heard is valid and I hear that as well," Watson said. "But once we sit down and walk them through the user experience of the customer and partner interaction online, it will create good optimism about their ability to be a rich part of the solution."
For instance, for partners who manage current customer Enterprise Agreements with Microsoft, the company's hosted business productivity suite will be just another product SKU in that agreement, she said. This means that partners will get existing revenue margins on Microsoft hosted services that their customers purchase just as they would on any other product, and continue to maintain their relationship with customers, Watson said.


Bought land in South Foster, Scituate, RI 02825.
Debra is the hardest working person I know. She is relentless when it comes to finding exactly what you are looking for. We had some very specific, uncommon requirements. We came close a few times and with the challenges in finding comparables as well as lenders who would finance our unique needs, it was no easy task. Debra also took her time guiding us and answering all of our questions in detail so that we could be morr educated buyers. I appreciated her handling our demands and complexities with much grace and patience.


text:
Rob Cragg (born September 26, 1953) is an American diver. He competed in the men's 3 metre springboard event at the 1976 Summer Olympics.

References

1953 births
Living people
American male divers
Olympic divers of the United States
Divers at the 1976 Summer Olympics
Sportspeople from  Pennsylvania

redpajama_set_name: RedPajamaWikipedia