One of my favourite male singing artists just released a hot track & music video today. I've got this tune & video on repeat.
Hello Stranger, let's have relations.
It's been a while & I still want to know what goes on beyond those eyes of yours.
I know it's hard to see things clearly until your hard exterior wears thin.
But clearly nothing is broken, only making a breakthrough.
I'll answer your questions with a smile.
You can feel it in the back of your throat.
Let it out, it's only me & you.
You're in love, this much is true.
You're always right, but oh so wrong.
Even in your red shirt love never dies.
There is no end with you in sight.
The rules don't matter, nothing says we have to say goodbye.
You don't have to keep me guessing to make it last.
We only see what we want to see & I want to see more of you.
Why are you trying to keep your love anonymous?
You could have my heart, if only you'd put your name on it.
Let's give our first kiss a second chance & see how long it last.
Every time feels like the first time regardless of the past.
Let's take what we can't take back.
You've got it all, if you've got me.
Can't replace the clarity you've claimed.
I never saw you coming.
You've left your mark upon everything without subtlety.
I can't see past you.
Seen it all a thousand times, but everything is a blur this time.
Searching for something I can't find without you.
Is this a cause for alarm?
It's clear I don't want to live without you, but you don't know what to do with me.
When we whispered in the dark we created a spark.
Love is a trip, watch me falling over the edge without a clue.
I miss what I never had whenever you pass through like a phantom pain.
Near or far, I can feel something which sight can't simply explain.
For better or worse, I'm on a collision course with the life painted inside your eyes.
Put your vision before mine.
Look me over as though my name has been set apart.
Show me a sign that we're closer than we seem.
Wash the blindness from these eyes.
Would it really be so dangerous?
This is how it begins, beautiful & fragile.


text:
(-) Remove <label class='research-domain' title='Genetics, Genomics, Bioinformatics and Systems Biology'>LS2 (1)</label> filter LS2 (1)
Project acronym CHAMELEON
Project Cellular Hypoxia Alters DNA MEthylation through Loss of Epigenome OxidatioN
Researcher (PI) Diether Lambrechts
Summary "DNA methylation was originally described in the 1970s as an epigenetic mark involved in transcriptional silencing, but the existence of DNA demethylation and the enzymes involved in this process were only recently discovered. In particular, it was established that TET hydroxylases catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxygen (O2) and 2-oxoglutarate (2OG). DNA demethylation as mediated by TET hydroxylases has so far predominantly been studied in the context of stem cells, but its precise contribution to carcinogenesis remains largely enigmatic. Nevertheless, somatic mutations in TETs have been identified in numerous cancers. Tumor hypoxia is linked to increased malignancy, poor prognosis and resistance to cancer therapies. In this proposal, we aim to assess how hypoxia directly impacts on the cancer epigenome through the dependence of TET-mediated DNA demethylation on O2. First of all, we will study the effect of O2 and 2OG concentration on TET hydroxylase activity, as well as the overall and locus-specific changes of their product (5hmC). Secondly, because much of the hypoxic response is executed through HIFs, we will investigate how HIF binding is influenced by DNA methylation and if so, whether TET hydroxylases are targeted to HIF (or other) binding sites to maintain them transcriptionally active. Thirdly, we will assess to what extent 5hmC profiles differ between tumor types and construct a comprehensive panel of (tumor-specific) 5hmC sites to assess the global and locus-specific relevance of 5hmC in various cancers. Finally, since hypoxia is a key regulator of the cancer stem cell (CSC) niche and within the tumor microenvironment also promotes metastasis, we will establish the in vivo relevance of DNA demethylation, as imposed by tumor hypoxia, in the CSC niche and during metastasis. Overall, we thus aim to establish the interplay between tumor hypoxia and the DNA methylome."
"DNA methylation was originally described in the 1970s as an epigenetic mark involved in transcriptional silencing, but the existence of DNA demethylation and the enzymes involved in this process were only recently discovered. In particular, it was established that TET hydroxylases catalyze the conversion of 5-methylcytosine (5mC) to 5-hydroxymethylcytosine (5hmC) through a reaction requiring oxygen (O2) and 2-oxoglutarate (2OG). DNA demethylation as mediated by TET hydroxylases has so far predominantly been studied in the context of stem cells, but its precise contribution to carcinogenesis remains largely enigmatic. Nevertheless, somatic mutations in TETs have been identified in numerous cancers. Tumor hypoxia is linked to increased malignancy, poor prognosis and resistance to cancer therapies. In this proposal, we aim to assess how hypoxia directly impacts on the cancer epigenome through the dependence of TET-mediated DNA demethylation on O2. First of all, we will study the effect of O2 and 2OG concentration on TET hydroxylase activity, as well as the overall and locus-specific changes of their product (5hmC). Secondly, because much of the hypoxic response is executed through HIFs, we will investigate how HIF binding is influenced by DNA methylation and if so, whether TET hydroxylases are targeted to HIF (or other) binding sites to maintain them transcriptionally active. Thirdly, we will assess to what extent 5hmC profiles differ between tumor types and construct a comprehensive panel of (tumor-specific) 5hmC sites to assess the global and locus-specific relevance of 5hmC in various cancers. Finally, since hypoxia is a key regulator of the cancer stem cell (CSC) niche and within the tumor microenvironment also promotes metastasis, we will establish the in vivo relevance of DNA demethylation, as imposed by tumor hypoxia, in the CSC niche and during metastasis. Overall, we thus aim to establish the interplay between tumor hypoxia and the DNA methylome."
Project acronym COMPAT
Project Complex Patterns for Strongly Interacting Dynamical Systems
Researcher (PI) Susanna Terracini
Host Institution (HI) UNIVERSITA DEGLI STUDI DI TORINO
Summary This project focuses on nontrivial solutions of systems of differential equations characterized by strongly nonlinear interactions. We are interested in the effect of the nonlinearities on the emergence of non trivial self-organized structures. Such patterns correspond to selected solutions of the differential system possessing special symmetries or shadowing particular shapes. We want to understand, from the mathematical point of view, what are the main mechanisms involved in the aggregation process in terms of the global variational structure of the problem. Following this common thread, we deal with both with the classical N-body problem of Celestial Mechanics, where interactions feature attractive singularities, and competition-diffusion systems, where pattern formation is driven by strongly repulsive forces. More precisely, we are interested in periodic and bounded solutions, parabolic trajectories with the final intent to build complex motions and possibly obtain the symbolic dynamics for the general N–body problem. On the other hand, we deal with elliptic, parabolic and hyperbolic systems of differential equations with strongly competing interaction terms, modeling both the dynamics of competing populations (Lotka- Volterra systems) and other interesting physical phenomena, among which the phase segregation of solitary waves of Gross-Pitaevskii systems arising in the study of multicomponent Bose-Einstein condensates. In particular, we will study existence, multiplicity and asymptotic expansions of solutions when the competition parameter tends to infinity. We shall be concerned with optimal partition problems related to linear and nonlinear eigenvalues
This project focuses on nontrivial solutions of systems of differential equations characterized by strongly nonlinear interactions. We are interested in the effect of the nonlinearities on the emergence of non trivial self-organized structures. Such patterns correspond to selected solutions of the differential system possessing special symmetries or shadowing particular shapes. We want to understand, from the mathematical point of view, what are the main mechanisms involved in the aggregation process in terms of the global variational structure of the problem. Following this common thread, we deal with both with the classical N-body problem of Celestial Mechanics, where interactions feature attractive singularities, and competition-diffusion systems, where pattern formation is driven by strongly repulsive forces. More precisely, we are interested in periodic and bounded solutions, parabolic trajectories with the final intent to build complex motions and possibly obtain the symbolic dynamics for the general N–body problem. On the other hand, we deal with elliptic, parabolic and hyperbolic systems of differential equations with strongly competing interaction terms, modeling both the dynamics of competing populations (Lotka- Volterra systems) and other interesting physical phenomena, among which the phase segregation of solitary waves of Gross-Pitaevskii systems arising in the study of multicomponent Bose-Einstein condensates. In particular, we will study existence, multiplicity and asymptotic expansions of solutions when the competition parameter tends to infinity. We shall be concerned with optimal partition problems related to linear and nonlinear eigenvalues
Project acronym HIGEOM
Project Highly accurate Isogeometric Method
Researcher (PI) Giancarlo Sangalli
Host Institution (HI) UNIVERSITA DEGLI STUDI DI PAVIA
Summary "Partial Differential Equations (PDEs) are widely used in science and engineering simulations, often in tight connection with Computer Aided Design (CAD). The Finite Element Method (FEM) is one of the most popular technique for the discretization of PDEs. The IsoGeometric Method (IGM), proposed in 2005 by T.J.R. Hughes et al., aims at improving the interoperability between CAD and FEMs. This is achieved by adopting the CAD mathematical primitives, i.e. Splines and Non-Uniform Rational B-Splines (NURBS), both for geometry and unknown fields representation. The IGM has gained an incredible momentum especially in the engineering community. The use of high-degree, highly smooth NURBS is extremely successful and the IGM outperforms the FEM in most academic benchmarks. However, we are far from having a satisfactory mathematical understanding of the IGM and, even more importantly, from exploiting its full potential. Until now, the IGM theory and practice have been deeply influenced by finite element analysis. For example, the IGM is implemented resorting to a FEM code design, which is very inefficient for high-degree and high-smoothness NURBS. This has made possible a fast spreading of the IGM, but also limited it to quadratic or cubic NURBS in complex simulations. The use of higher degree IGM for real-world applications asks for new tools allowing for the efficient construction and solution of the linear system, time integration, flexible local mesh refinement, and so on. These questions need to be approached beyond the FEM framework. This is possible only on solid mathematical grounds, on a new theory of splines and NURBS able to comply with the needs of the IGM. This project will provide the crucial knowledge and will re-design the IGM to make it a superior, highly accurate and stable methodology, having a significant impact in the field of numerical simulation of PDEs, particularly when accuracy is essential both in geometry and fields representation."
"Partial Differential Equations (PDEs) are widely used in science and engineering simulations, often in tight connection with Computer Aided Design (CAD). The Finite Element Method (FEM) is one of the most popular technique for the discretization of PDEs. The IsoGeometric Method (IGM), proposed in 2005 by T.J.R. Hughes et al., aims at improving the interoperability between CAD and FEMs. This is achieved by adopting the CAD mathematical primitives, i.e. Splines and Non-Uniform Rational B-Splines (NURBS), both for geometry and unknown fields representation. The IGM has gained an incredible momentum especially in the engineering community. The use of high-degree, highly smooth NURBS is extremely successful and the IGM outperforms the FEM in most academic benchmarks. However, we are far from having a satisfactory mathematical understanding of the IGM and, even more importantly, from exploiting its full potential. Until now, the IGM theory and practice have been deeply influenced by finite element analysis. For example, the IGM is implemented resorting to a FEM code design, which is very inefficient for high-degree and high-smoothness NURBS. This has made possible a fast spreading of the IGM, but also limited it to quadratic or cubic NURBS in complex simulations. The use of higher degree IGM for real-world applications asks for new tools allowing for the efficient construction and solution of the linear system, time integration, flexible local mesh refinement, and so on. These questions need to be approached beyond the FEM framework. This is possible only on solid mathematical grounds, on a new theory of splines and NURBS able to comply with the needs of the IGM. This project will provide the crucial knowledge and will re-design the IGM to make it a superior, highly accurate and stable methodology, having a significant impact in the field of numerical simulation of PDEs, particularly when accuracy is essential both in geometry and fields representation."
Project acronym HoloQosmos
Project Holographic Quantum Cosmology
Researcher (PI) Thomas Hertog
Summary The current theory of cosmic inflation is largely based on classical physics. This undermines its predictivity in a world that is fundamentally quantum mechanical. With this project we will develop a novel approach towards a quantum theory of inflation. We will do this by introducing holographic techniques in cosmology. The notion of holography is the most profound conceptual breakthrough that has emerged form fundamental high-energy physics in recent years. It postulates that (quantum) gravitational systems such as the universe as a whole have a precise `holographic' description in terms of quantum field theories defined on their boundary. Our aim is to develop a holographic framework for quantum cosmology. We will then apply this to three areas of theoretical cosmology where a quantum approach is of critical importance. First, we will put forward a holographic description of inflation that clarifies its microphysical origin and is rigorously predictive. Using this we will derive the distinct observational signatures of novel, truly holographic models of the early universe where inflation has no description in terms of classical cosmic evolution. Second, we will apply holographic cosmology to improve our understanding of eternal inflation. This is a phase deep into inflation where quantum effects dominate the evolution and affect the universe's global structure. Finally we will work towards generalizing our holographic models of the primordial universe to include the radiation, matter and vacuum eras. The resulting unification of cosmic history in terms of a single holographic boundary theory may lead to intriguing predictions of correlations between early and late time observables, tying together the universe's origin with its ultimate fate. Our project has the potential to revolutionize our perspective on cosmology and to further deepen the fruitful interaction between cosmology and high-energy physics.
The current theory of cosmic inflation is largely based on classical physics. This undermines its predictivity in a world that is fundamentally quantum mechanical. With this project we will develop a novel approach towards a quantum theory of inflation. We will do this by introducing holographic techniques in cosmology. The notion of holography is the most profound conceptual breakthrough that has emerged form fundamental high-energy physics in recent years. It postulates that (quantum) gravitational systems such as the universe as a whole have a precise `holographic' description in terms of quantum field theories defined on their boundary. Our aim is to develop a holographic framework for quantum cosmology. We will then apply this to three areas of theoretical cosmology where a quantum approach is of critical importance. First, we will put forward a holographic description of inflation that clarifies its microphysical origin and is rigorously predictive. Using this we will derive the distinct observational signatures of novel, truly holographic models of the early universe where inflation has no description in terms of classical cosmic evolution. Second, we will apply holographic cosmology to improve our understanding of eternal inflation. This is a phase deep into inflation where quantum effects dominate the evolution and affect the universe's global structure. Finally we will work towards generalizing our holographic models of the primordial universe to include the radiation, matter and vacuum eras. The resulting unification of cosmic history in terms of a single holographic boundary theory may lead to intriguing predictions of correlations between early and late time observables, tying together the universe's origin with its ultimate fate. Our project has the potential to revolutionize our perspective on cosmology and to further deepen the fruitful interaction between cosmology and high-energy physics.
Project acronym RIGIDITY
Project Rigidity and classification of von Neumann algebras
Researcher (PI) Stefaan Vaes
Summary "Sorin Popa's deformation/rigidity theory has lead to an enormous progress in our understanding of von Neumann algebras coming from discrete groups and their actions on probability spaces. In a five year long collaboration with Sorin Popa, we solved many long-standing open problems in this area, including superrigidity theorems for group measure space II_1 factors, results on the possible fundamental groups of II_1 factors, and uniqueness theorems for Cartan subalgebras. In the first part of the project, we want to establish new unique Cartan decomposition theorems for II_1 factors coming from hitherto intractable groups. Using methods coming from Lie groups, ergodic theory and geometric group theory, we want to reach such results for lattices in higher rank simple Lie groups, and for countable groups with nonvanishing L^2-Betti numbers. An important intermediate step will be the unique Cartan decomposition of Bernoulli crossed products. Secondly we want to prove classification theorems for type III factors that are equally strong as the existing results for the type II_1 case. This includes a complete classification of the noncommutative Bernoulli shifts of the free groups and will require an intricate combination of Tomita/Takesaki and deformation/rigidity theory. The methods developed so far bring within reach an attack on two of the most important open problems in operator algebras and functional analysis: the free group factor problem and Connes's rigidity conjecture. The exact progress on these problems is of course unforeseeable, but it is sure that the research on these problems will lead to an even deeper interaction between diverse areas of mathematics as operator algebras, group theory, functional analysis, ergodic theory, and descriptive set theory. Intermediate goals are the classification of natural classes of group von Neumann algebras, including those coming from Baumslag-Solitar groups, wreath product groups, and other families of discrete groups."
"Sorin Popa's deformation/rigidity theory has lead to an enormous progress in our understanding of von Neumann algebras coming from discrete groups and their actions on probability spaces. In a five year long collaboration with Sorin Popa, we solved many long-standing open problems in this area, including superrigidity theorems for group measure space II_1 factors, results on the possible fundamental groups of II_1 factors, and uniqueness theorems for Cartan subalgebras. In the first part of the project, we want to establish new unique Cartan decomposition theorems for II_1 factors coming from hitherto intractable groups. Using methods coming from Lie groups, ergodic theory and geometric group theory, we want to reach such results for lattices in higher rank simple Lie groups, and for countable groups with nonvanishing L^2-Betti numbers. An important intermediate step will be the unique Cartan decomposition of Bernoulli crossed products. Secondly we want to prove classification theorems for type III factors that are equally strong as the existing results for the type II_1 case. This includes a complete classification of the noncommutative Bernoulli shifts of the free groups and will require an intricate combination of Tomita/Takesaki and deformation/rigidity theory. The methods developed so far bring within reach an attack on two of the most important open problems in operator algebras and functional analysis: the free group factor problem and Connes's rigidity conjecture. The exact progress on these problems is of course unforeseeable, but it is sure that the research on these problems will lead to an even deeper interaction between diverse areas of mathematics as operator algebras, group theory, functional analysis, ergodic theory, and descriptive set theory. Intermediate goals are the classification of natural classes of group von Neumann algebras, including those coming from Baumslag-Solitar groups, wreath product groups, and other families of discrete groups."
Project acronym SPECULOOS
Project SPECULOOS: searching for habitable planets amenable for biosignatures detection around the nearest ultra-cool stars
Researcher (PI) Michaël Gillon
Host Institution (HI) UNIVERSITE DE LIEGE
Summary "One of the most significant goals of modern astronomy is establishing whether life exists around other stars. The most direct path towards its achievement is the detection and spectroscopic characterization of terrestrial planets orbiting in the habitable zone of their host stars. The ~1000 nearest ultra-cool stars (UCS, spectral type M6 and latter) represent a unique opportunity to reach this goal within the next decade. Due to their small luminosity, their habitable zone is 30-100 times closer than for the Sun, the corresponding orbital periods ranging from one to a few days. Thanks to this proximity, the transits of habitable planets are much more probable and frequent than for Earth-Sun analogs, while the small size of UCS (~1 Jupiter radius) leads to transits deep enough for a ground-based detection, even for sub-Earth sized planets. Furthermore, habitable planets transiting nearby UCS would be amenable for a thorough atmospheric characterization with near-to-come world-class facilities, including the detection of possible biosignatures. Detecting such planets is the goal of SPECULOOS. Its instrumental concept is optimized for the detection of planets of Earth-size and below transiting the nearest Southern UCS. It consists in several robotic 1m-class telescopes equipped with new generation CCD cameras optimized for the near-IR and operating from one of the best astronomical sites of the Southern hemisphere. SPECULOOS will perform the first exploration of the Terra Incognita of planets around UCS, and detect the first terrestrial planets amenable for atmospheric characterization."
"One of the most significant goals of modern astronomy is establishing whether life exists around other stars. The most direct path towards its achievement is the detection and spectroscopic characterization of terrestrial planets orbiting in the habitable zone of their host stars. The ~1000 nearest ultra-cool stars (UCS, spectral type M6 and latter) represent a unique opportunity to reach this goal within the next decade. Due to their small luminosity, their habitable zone is 30-100 times closer than for the Sun, the corresponding orbital periods ranging from one to a few days. Thanks to this proximity, the transits of habitable planets are much more probable and frequent than for Earth-Sun analogs, while the small size of UCS (~1 Jupiter radius) leads to transits deep enough for a ground-based detection, even for sub-Earth sized planets. Furthermore, habitable planets transiting nearby UCS would be amenable for a thorough atmospheric characterization with near-to-come world-class facilities, including the detection of possible biosignatures. Detecting such planets is the goal of SPECULOOS. Its instrumental concept is optimized for the detection of planets of Earth-size and below transiting the nearest Southern UCS. It consists in several robotic 1m-class telescopes equipped with new generation CCD cameras optimized for the near-IR and operating from one of the best astronomical sites of the Southern hemisphere. SPECULOOS will perform the first exploration of the Terra Incognita of planets around UCS, and detect the first terrestrial planets amenable for atmospheric characterization."
Project acronym STARKEY
Project Solving the TP-AGB STAR Conundrum: a KEY to Galaxy Evolution
Researcher (PI) Paola Marigo
Summary "Models of the Thermally Pulsing Asymptotic Giant Branch (TP-AGB) stellar evolutionary phase play a critical role across astrophysics, from the chemical composition of meteorites belonging to the pre-solar nebula up to galaxy evolution in the high-redshift Universe. In spite of its importance, the modelling of TP-AGB is still affected by large uncertainties that propagate into the field of extragalactic astronomy, degrading the predicting power of current population synthesis models of galaxies. The major goal of this proposal is to remedy this persistent condition of uncertainty and controversy. The solution to the TP-AGB star conundrum will be provided by a new approach, which stands on the optimised integration of a) state-of-the-art theoretical tools to account for the complex physics of TP-AGB stars (evolution, nucleosynthesis, pulsation, winds, dust formation, etc.), and b) exceptionally high-quality observations of resolved TP-AGB stellar populations in stars clusters and nearby galaxies (Magellanic Clouds, M31, dwarf galaxies up to 4 Mpc) with reliable measurements of their star formation histories. We will adopt a global calibration method, in which TP-AGB evolution models are required to simultaneously reproduce a set of well-defined observational constraints (distributions of luminosities, colours, pulsation periods, dust mass-loss rates, expansion velocities of dusty envelopes, etc.). This project will deepen our understanding of TP-AGB physics profoundly, and provide wide-spread community benefits as well. We will publicly release well-tested and reliable ``TP-AGB products'', including stellar tracks, isochrones in all photometric systems, and chemical yields for both gas and dust. Eventually these products will be embedded in the stellar population synthesis models that are routinely used to analyse the integrated galaxy observables that probe the extragalactic Universe."
"Models of the Thermally Pulsing Asymptotic Giant Branch (TP-AGB) stellar evolutionary phase play a critical role across astrophysics, from the chemical composition of meteorites belonging to the pre-solar nebula up to galaxy evolution in the high-redshift Universe. In spite of its importance, the modelling of TP-AGB is still affected by large uncertainties that propagate into the field of extragalactic astronomy, degrading the predicting power of current population synthesis models of galaxies. The major goal of this proposal is to remedy this persistent condition of uncertainty and controversy. The solution to the TP-AGB star conundrum will be provided by a new approach, which stands on the optimised integration of a) state-of-the-art theoretical tools to account for the complex physics of TP-AGB stars (evolution, nucleosynthesis, pulsation, winds, dust formation, etc.), and b) exceptionally high-quality observations of resolved TP-AGB stellar populations in stars clusters and nearby galaxies (Magellanic Clouds, M31, dwarf galaxies up to 4 Mpc) with reliable measurements of their star formation histories. We will adopt a global calibration method, in which TP-AGB evolution models are required to simultaneously reproduce a set of well-defined observational constraints (distributions of luminosities, colours, pulsation periods, dust mass-loss rates, expansion velocities of dusty envelopes, etc.). This project will deepen our understanding of TP-AGB physics profoundly, and provide wide-spread community benefits as well. We will publicly release well-tested and reliable ``TP-AGB products'', including stellar tracks, isochrones in all photometric systems, and chemical yields for both gas and dust. Eventually these products will be embedded in the stellar population synthesis models that are routinely used to analyse the integrated galaxy observables that probe the extragalactic Universe."
Project acronym vortex
Project Taking extrasolar planet imaging to a new level with vector vortex coronagraphy
Researcher (PI) Olivier Absil
Summary Vector vortex coronagraphs (VVC) are among the most promising solutions to directly image faint extrasolar planets by dimming the glare of their nearby host star. Manufacturing and efficiently operating such devices is however a challenging enterprise, especially in the thermal infrared regime where warm planets radiate most of their energy. For several years, we have been developing a new class of VVC, called the Annular Groove Phase Mask (AGPM) coronagraph. Etched on a diamond substrate, this coronagraph can be operated at any wavelength, including the thermal infrared, thanks to the excellent transparency properties of diamond. We are now at a stage where the first components have been manufactured and tested. The proposed research program has three main goals. First, we will install and exploit the first generation of AGPM coronagraphs on large telescopes in world-leading observatories. By providing a means to efficiently cancel the starlight in the thermal infrared regime for the first time, our AGPMs will significantly contribute to the discoveries and characterisation of exoplanets beyond a few astronomical units. Second, we aim at developing new AGPM coronagraphs for the next generation of imaging instruments. We will particularly focus our developments on the instruments planned for the future extremely large telescopes, which will bring the direct imaging of exoplanets to a new level. Finally, we will study, develop and test a ground-breaking concept that could improve very significantly the on-sky performance of VVCs in general. This concept is based on the quantum properties of light and in particular on the fact that an optical vortex induces an orbital angular momentum on the input starlight. We propose to use an interferometric device to sort photons based on their orbital angular momentum, so as to separate the planetary light from the residual starlight (including the speckles created by atmospheric turbulence) at the output of the coronagraph.
Vector vortex coronagraphs (VVC) are among the most promising solutions to directly image faint extrasolar planets by dimming the glare of their nearby host star. Manufacturing and efficiently operating such devices is however a challenging enterprise, especially in the thermal infrared regime where warm planets radiate most of their energy. For several years, we have been developing a new class of VVC, called the Annular Groove Phase Mask (AGPM) coronagraph. Etched on a diamond substrate, this coronagraph can be operated at any wavelength, including the thermal infrared, thanks to the excellent transparency properties of diamond. We are now at a stage where the first components have been manufactured and tested. The proposed research program has three main goals. First, we will install and exploit the first generation of AGPM coronagraphs on large telescopes in world-leading observatories. By providing a means to efficiently cancel the starlight in the thermal infrared regime for the first time, our AGPMs will significantly contribute to the discoveries and characterisation of exoplanets beyond a few astronomical units. Second, we aim at developing new AGPM coronagraphs for the next generation of imaging instruments. We will particularly focus our developments on the instruments planned for the future extremely large telescopes, which will bring the direct imaging of exoplanets to a new level. Finally, we will study, develop and test a ground-breaking concept that could improve very significantly the on-sky performance of VVCs in general. This concept is based on the quantum properties of light and in particular on the fact that an optical vortex induces an orbital angular momentum on the input starlight. We propose to use an interferometric device to sort photons based on their orbital angular momentum, so as to separate the planetary light from the residual starlight (including the speckles created by atmospheric turbulence) at the output of the coronagraph.

redpajama_set_name: RedPajamaCommonCrawl


Firemedically Speaking host Mike McEvoy talks with Daniel Patterson, PhD, NRP, the Principal Investigator for the NHTSA Funded Project developing evidenced based guidelines on Risk Management for Fatigue in EMS. Dr. Patterson is a researcher at the University of Pittsburgh and an actively practicing paramedic. Learn what's been discovered about fatigue in EMS and where the research project is headed.


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Nils Kreuger
vinterkvall i varberg
Painting ID: 70032
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Nils Kreuger:
Swedish, 1858-1930,Swedish painter, draughtsman and illustrator. From 1874 he studied at the Konstakademi in Stockholm, where he soon became a friend of Richard Bergh and Karl Nordstrem, both of whom were later prominent exponents of the more advanced Swedish painting of the 1880s and 1890s. After being forced to interrupt his studies because of illness, Kreuger trained from 1878 at the art school of Edvard Perseus (1841-90) in Stockholm before he travelled to Paris, where he stayed for the most part until 1887. He made his d?but at the Paris Salon in 1882, and he also resided in the artists' colony in Grez-sur-Loing. During this period he painted such works as Old Country House (1887; Stockholm, Nmus.) with a free brushwork and sense of light that owed much to Jules Bastien-Lepage. In 1885 Kreuger was active in organizing the Opponenterna, a protest movement led by Ernst Josephson against the conservative establishment of the Konstakademi in Stockholm, and the following year he helped to found the Konstn?rsf?rbund (Artists' Union). Like the majority of the Konstnersferbund's members, Kreuger abandoned the French-inspired plein-air realism of the 1880s for symbolically coloured National Romanticism in the 1890s. For Kreuger this change took place between 1893 and 1896 in Varberg on the west coast of Sweden, where, together with Bergh and Nordstrem, he founded the Varberg Group. Drawing on Paul Gauguin's Synthetism, the group contributed to the formation of the National Romantic style of the 1890s in Sweden. Kreuger's encounter with van Gogh's drawings at an exhibition in Copenhagen in 1893 also played a decisive role in his development. He devised an intensely personal style in which the landscape was composed in large blocks that were then covered by a pattern of directional lines and dots in India ink (somewhat in the manner of van Gogh's late landscape drawings) to bring out the painting's colour values and create an effect of decoratively stylized forms: for example Spring in Halland (1894; Stockholm, Nmus.). Kreuger was also a prolific draughtsman and illustrator.
Related Paintings to Nils Kreuger :.
| Oil painting in Sweden | Jan Steen - A Young Woman playing a Harpsichord to a Young Man | Gaudenzio Ferrari - Saint Andrew | PIERRE-AUGUSTE RENOIR-LA LECTURE | Ribalta, Francisco-San Francisco confortado por un angel musico | Jan van Eyck - Virgin and Child, with Saints and Donor, early 1440s | Paul Cezanne-Portrait of Madame Cezanne | Michelangelo Buonarroti-David and Goliath | Henri Matisse-Le Marabout (mk35) | Alexander Roslin-Jean Francois Marmontel | Job Adriaenszoon Berckheyde-A Notary in His Office |
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GAINESVILLE, Fla. – The University of Florida recognized the 2018 Gator100 honorees on Friday at the Reitz Union Grand Ballroom.
Presented by the UF Alumni Association and the Entrepreneurship & Innovation Center at the Warrington College of Business, the Gator100 honors the 100 fastest-growing Gator-owned or Gator-led businesses in the world. The event serves not only as a setting where UF's elite entrepreneurs can gather and share their talents and wisdom, but as an inspiration to fellow Gators to be a part of this exclusive group.
The Gator100 honorees total $6.2 billion in 2016 earned revenues, employ 43,679 people at their companies, represent 17 states across the U.S. and include two internationally-based companies.
Companies are ranked by compound annual growth rate over the past three years, determined by the global accounting firm Ernst & Young. View the complete list of Gator100 honorees here.
ACY Contractors was the top-ranked company with a compound annual growth rate of 159.51 percent. The Orlando-based company provides construction management, general and trade construction services for K-12, higher education, healthcare, federal and other niche markets. ACY is led by Michael Young, a graduate of the College of Design, Construction & Planning.
NuJak Companies, led by the College of Design, Construction & Planning's Frank Kendrick, came in second with 147.44 percent compound annual growth. Salon's Choice came in third with 144.04 percent compound annual growth. Salon's Choice is led by Warrington alumnus Oren Kantor.
Power Production Management, led by Herbert Wertheim College of Engineering alumnus Jason Gonos, came in fourth place with 108.71 percent compound annual growth. Veteran Energy, led by College of Liberal Arts & Sciences alumnus Darin Cook, rounded out the top 5 with 104.01 percent compound annual growth.
Alex Moreno of Nightingale Nurses won the S. Clark Butler Pinnacle Award, which recognizes an established business leader who has demonstrated success in their industry. The recipient is an entrepreneur who has shown sustained excellence and leadership. Moreno is the CEO and co-founder of the healthcare staffing company and is an alumnus of the Herbert Wertheim College of Engineering's Chemical Engineering department.
Thirty-four of the 100 companies honored on the list are led or owned by Warrington alumni. Since the Gator100 was founded in 2015, more than 150 companies led or owned by Warrington alumni have been included on the Gator100. Five of those companies have been on the list all 4 years including Cabinets.com, Study Edge, Victory Tailgate, SSP Innovations and The Bowman Law Firm.
Three of the companies in the top 10 are led by Warrington alumni. Salon's Choice (#3) is led by President and CEO Oren Kantor (BSBA '10, MSE '11), Todd Hoffman (BSBA '02, MS '03) is the CFO of Chloe's Fruit (#7), and Orlando Legal is led by CEO/Managing Partner Jonathan Simon (BSBA '04, MA '05, JD '07) and Attorney/Co-Owner Jill Simon (BSBA '04, JD '07). In addition, 10 of the top 20 are led or owned by Warrington alumni including RedTeam Software (#12), Cabinets.com (#13), RVG & Company (#14), AspirEDU (#15), Abode Luxury Rentals (#17), JWB Real Estate Companies (#18) and The Free Ride (#20).
To be considered for the Gator100, companies must have been in business for five years or more as of Oct. 1, 2017 and have had verifiable annual revenues of $250,000 or more in 2014, or for the past three full fiscal years.
A University of Florida alumnus or group of alumni must have owned 50% or more of the company from Jan. 1, 2014 through Oct. 1, 2017.
A University of Florida alumnus must have served as the company's chief executive (for example: chairman, CEO, president or managing partner) from Jan. 1, 2014 through Oct. 1, 2017.
A University of Florida alumnus must have founded the company and been active as a member of the most senior management team from Jan. 1, 2014 through Oct. 1, 2017.


Factory fitted, this mouthpiece is a little broader than what we're used to : it's more like a 'drip tip' style mouthpiece.
But it's got this funky little quirk that I discovered purely by accident : the factory fitted mouthpiece is actually a 510 fitting in itself, meaning that you can put any standard 510 fitting mouthpiece into the existing mouthpiece . . . neat trick, huh?


look it up on youtube, there are instructional videos on how to torrent it.
When a board lacks an active moderator or needs more moderation, the staff talks about whom we might be able to put there; sometimes an existing mod that already frequents the board gets power there, other times we find a suitable regular visitor to the board in question and make him/her a moderator.
Apathy was an alternate account, hence the ban.
Can you smash this afternoon?


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Not content with just checking out Prerisoft? Here are a number of other sites that I feel are worth attention, whether due to similar scope or relevance, or being useful resources themselves. Once I start working with other folks on projects, I will be linking to those sites as well, but all in due time.


text:
Vojkov is a municipality and village in Benešov District in the Central Bohemian Region of the Czech Republic. It has about 500 inhabitants.

Administrative parts
Villages and hamlets of Bezmíř, Křenovice, Lhotka, Minartice, Podolí, Sledovice, Voračice and Zahrádka are administrative parts of Vojkov.

Gallery

References

Villages in Benešov District

redpajama_set_name: RedPajamaWikipedia


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Contrary to some beliefs, the best thing about the 80s wasn't the leg warmers. It was the music (duh)! Madonna, Foreigner, and Journey - oh my! The era of the music royalty: King of Pop, Prince, and Queen. And of course, the number no one could get out of their head: 867-5309. The 80s was full of classic rock hair bands and pop greats. Gotta give some love to the one-hit wonders of the 80s: Whip It, Tainted Love, and Come on Eileen. Come on, who doesn't love the 80s!? Book one of these 80s acts today! Search for 1980s Era Entertainment in Longueuil, Quebec above.
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text:
Barkouf är en opéra bouffe i tre akter med musik av Jacques Offenbach och libretto av Eugène Scribe och Henry Boisseaux, efter Abbé Blanchet, den fjärde av hans Contes Orientaux med titeln Barkouf et Mani. Titelrollen är en hund. Det var det första verket av Offenbach som hade premiär på Opéra-Comique i Paris den 24 december 1860, men sedan uppfördes den inte förrän 2018.

Historia
Efter succén med enaktare och längre stycken på Bouffes-Parisiens blev Barkouf Offenbachs första försök att ta sig in i repertoaren på ett av Paris större operahus, Opéra-Comique, vilket senare skulle kulminera med Hoffmanns äventyr 1881. Verket var beställt av operahuset men möttes av fientlighet hos sångarna under repetitionerna och av kritikerna vid premiären. Den nye operachefen Alfred Beaumont tillträdde i juni 1860 och hoppades dra nytta av Offenbachs spirande berömdhet genom att koppla samman honom med den berömde librettisten Eugène Scribe. Den senare hade redan skissat på ett librettot som var ämnat för kompositören Louis Clapisson och sångerskan Delphine Ugalde, och Scribes yngre medarbetare Boisseaux sattes att färdigställa verket. I mitten av augusti skrev Paris tidningar att verket (som då kallades Le Sultan Barkouf) redan hade rollbesatts och repetitionerna var i gång. Några av de inblandade var rasande att Offebach hade fått tillåtelse att komponera för Frankrikes näst viktigaste scen, och Ugalde var den starkaste kritikern. Därefter följde problem med censuren, vilken protesterade emot att det "konstiga" stycket utspelades i ett fantasiland och att vicekungarna av Lahore defenestrerades och beslöt att förbjuda operetten. Beaumont försökte beveka censuren genom att ta bort alla referenser till 'ledare' och 'herre'. Med dessa och andra mindre förändringar, samt en försäkran från Beaumont att ett förbud skulle bli för kostsamt för hans nya ledning, lät censuren stycket passera. Ugalde ersattes först av Mlle de Saint-Urbain och senare av Mlle Marimon, villet ytterligare försenade uppsättningen. Verket uppfördes i Salle Favart den 24, 26, 28, 31 december 1860, 2, 10, 12, och 16 januari 1861, med flera rolländringar. Yon skriver att publikens reaktioner var positiva och att ensemblens brist på samarbeta inte ska överdrivas; det var pressens kritiska inställning som förhindrade en längre succé för Barkouf.

Hector Berlioz var särskilt kritiks till Offenbachs hantverk och ifrågasatte 'vissa musikers förvridna sinne' och införandet av element av 'bouffe' på Opéra-Comique medan han samtidigt kungjorde att han aldrig hade satt sig fot på sådana teatrar. I sin Dictionnaire des opéras från 1869 noterade Félix Clément lättheten och den geniala uppbyggnaden i två eller tre kördelar, men var annars besviken över frånvaron av originalitet hos kompositören. Moderna tankar har ifrågasatt detta synsätt; dirigenten vid nyuppsättningen i Strasbourg hävdar att Barkouf är "ett viktigt verk... en operett att räknas in bland kompositörens största succéer" och att verkets 100 minuter är värda ett entusiastiskt bemötande.
En del av musiken återanvändes i Boule de neige från 1871, där en björn ersatte hunden som titelroll.

Efter att operetten lades ned 1861 uppfördes den inte förrän i december 2018 då Opéra du Rhin satte upp den i Strasbourg den 7 december, dirigerad av Jacques Lacombe och regisserad av Mariame Clément, som skrev om mycket av den talade dialogen.

De flesta av Offenbachs manuskript har gått i arv i familjen och verkets förlorade sidor lyckades Jean-Christophe Keck finnaa i andra samlingar. Originallibrettot överensstämmer dock inte med partituret. Orkestermaterial och repetitionspapper förstördes troligen i en brand på Opéra-Comique 1887. Offenbach hade åtnjutit en viss respekt från sina kollegor så länge som han höll sig till den lättare genren på Bouffes-Parisiens, men i Barkouf skrev han en mer komplex musik med moderna harmonier samtidigt som han var kvar i den lättare genrens anda. Keck noterar exempelvis den lyriska duetten i första akten med sina överraskande harmonier och dryckessången i akt III. Med tanke på musikens experimentella karaktär är det förståeligt med kritikernas reaktion på dess sofistikerade moduleraringar, polytonala passager, samt krävande och ovanliga sångstil; Keck skriver att kompositören inte tidigare hade utmanat sitt musikaliska språk så långt, och skulle inte göra så heller - förrän i Hoffmanns äventyr.

Personer

Handling
Akt I

Marknadsdag i Lahore. De två gatuförsäljarna Maïma och Balkis ordnar sina varor. Den korrupte munskänken Bababeck flörtar med de unga kvinnorna. Han är änkling och allra redan lite för gammal, men han inbillar sig att han är attraktiv och längtar efter den dag då han har gift bort sin fula dotter Périzade, då han fullt ut kan njuta av ungkarlslivet. På avstånd hörs upprörda rop. Bababeck, som anar det värsta, rusar till sitt hus. Balkis oroar sig för sin älskade Xaïloum, som aldrig försitter tillfället att ställa till uppror, och han anar att hon är inblandad i upproret. Maïma är också orolig och berättar för Balkis att han sörjer förlusten av sin älskade Saëb och hennes trogna hund Barkouf, vilka båda fördes bort en tid tillbaka av arméns rekryterare. Under tiden har ännu en guvernör kastats ut från ett fönster. På detta sätt får den utnyttjade och plågade befolkningen utlopp för sina känslor, men med resultatet att efterträdaren styr riket än mer hårdare än sin föregångare. Bland upprorsmännen återfinns Xaïloum som tog ut sin ilska genom att demolera Bababecks residens och därför måste gömma sig.

I stället för att utnämna Bababeck till den guvernören (som Bababecka hade hoppats och förväntat sig) bestämmer Stormogulen att göra sin hund till överhuvud för Lahores regering. Bababeck utnämns till visir och får i order att utföra hundens nya lagar och förordningar. Om han vägrar kan han förvänta sig att bli bestraffad. Maïma nästan svimmar när hon ser den försvunne Saëb som soldat i Stormogulens vaktstyrka och att hennes hund Barkouf har blivit utnämnd till ny guvernör!

Akt II

Bababeck oroar sig för att hans kommande svärson - den otursförföljde Saëb - ska ge hans dotter korgen när han ser henne. Därför beordrar han Périzade att ta emot Saëb med en slöja för ansiktet. Périzade vill veta hur fadern, efter så många år, har lyckats finna en friare till henne. Förklaringen är enkel: Bababeck har bevis för att Saëbs fader planerade en attack på den förre guvernören, och han över utpressning mot honom. Äktenskapet mellan Saëb och Périzade är priset för Bababecks tystnad. För att rädda fadern accpterar Saëb sitt öde utan att känna till sin kommande brud. Nu återstår endast guvernörens skrivna och muntliga godkännande. Men Bababecks tjänare Kaliboul, som skickades till Barkouf för att få äktenskapet godkänt, fasar för att eventuellt bli ihjälbiten av Barkouf och återvänder vit som ett lakan och utan godkännande. Förseningen är en besvikelse för Périzade och Bababeck, och en stor lättnad för Saëb, som efter flera års separation endast kan tänkt på en sak: hans förlorade Maïma.

Maïma anländer till palatset och begär att bli förd inför den nye guvernören. Bababeck känner igen den unga flickan från marknaden. Hon lyckas lugna hans farhågor att Barkouf ska slita henne i stycken. Förr var de bästa vänner och han åt bokstavligt talat ur handen på henne. Bababeck tar tillfället i akt och avslöjar sin briljanta plan för Maïma. Han ska utnämna henne till Barkoufs sekreterare och översättare, då hon är den enda som Barkouf tillåter komma nära honom och som förstår hans skall. Bababecks egna beslut kan därmed med hjälp av Maïmas översättning meddelas invånarna utan att de inser sanningen. Maïma går med på det hela.

Hon går till Barkoufs kammare. Till allas förvåning blir hunden salig av glädje vid åsynen av henne och i stället för att anfalla henne viftar han på svansen. Maïma återvänder med äktenskapslicensen "undertecknad" av Barkouf, men hon inser inte att hon därmed har godkänt Saëbs äktenskap med Périzade. Bababeck triumferar. En medborgardelegation från Lahore överräcker en petition i vilken en skattesänkning önskas då befolkningen dignar under skattetrycket. Maïma går till Barkouf och "översätter" sedan hans skall - men inte, som Bababeck viskar i hennes öra, som ett avslag utan som ett godkännande. Bababeck tror fortfarande att det kan röra sig om ett missförstånd, men nästa petition är en önskan om nåd för Xaïloum, som har dömts till döden. Maïma "översätter" på nytt Barkoufs skall som ett avslag på Bababecks förslag, nämligen nåd för Xaïloum. Medan folket hurrar den vise och gode ledaren inser Bababeck slutligen att han har blivit lurad. Han ruvar på hämnd.

Maïmas lycka förbyts till sorg när hon ser Saëb vid Périzades sida med bröllopsvittnena på väg till guvernören. Maïma vet inget om fädernas överenskommelse och antar att Saëb har brutit sitt trohetslöfte till henne. Bababeck kan inte hindra Maïma från att en tredje gång "översätta" mot hans vilja. Barkouf tar tillbaka sitt tidigare godkännande av äktenskapet mellan Saëb och Périzade - hans ilskna skall tvivlar ingen på och Maïma översätter villigt.

Akt III

Det finns bara ett sätt att stoppa Maïmas okontrollerade handlingar: guvernören "själv" måste göra sig av med henne. En samling av konspiratörer och avskedade hovmän planerar att förgifta Barkouf. Samtidigt har tatarerna samlats utanför staden, som nu har blivit ett lätt byte sedan stormogulens trupper är på annat håll. Xaïloum överhör konspirationen. Men  då han endast har hört en del av planen kan han bara ge Maïma en ofullständig rapport. Under tiden har Maïma kunnat prata med Saëb och vet nu anledningen till giftermålet. Hon planerar att ta konspiratörerna till fånga. Under kvällens bankett läggs gift i Barkoufs vin. Men Maïma beordrar konspiratörerna att dricka från samma vin och komplotten avslöjas. Just då stormar tartarerna in i staden. Folket tar till vapen. Anförda av Barkouf och Saëb motar de bort inkräktarna. Stormogulen återvänder och kan endast legitimera de nya omständigheterna: giftermålet mellan Maïma och Saëb. Barkouf har dött i striden och Saëb utnämns till ny guvernör.

Referenser

Noter

Litteratur
 Das gefährliche Debüt Offenbachs an der Opéra-Comique: Barkouf (1860). In: Elisabeth Schmierer (ed.): Jacques Offenbach und seine Zeit. Regensburg 2009.
 Jean-Claude Yon: Jacques Offenbach. Éditions Gallimard, Paris, 2000

Opéra bouffe
Operetter av Jacques Offenbach
Musikåret 1860


Essam Yousef, the head of the Global Committee to Support Gaza, called on Wednesday for Arab and Muslim countries to close US embassies in their capital cities following Donald Trump's recognition of Jerusalem as the capital of Israel, Safa news agency has reported.
Yousef also called on the Palestine Liberation Organization to rescind its formal recognition of Israel, and stressed that all Arab and Muslim states should withdraw any delegations that they might have in Israel.
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Denouncing this "international conspiracy," Dr. Yousef suggested that Arab and Muslim states should withdraw their representatives from the UN, as well as their ambassadors from the United States, in an act of solidarity and protest.


Here at Bob's Market & Greenhouses, we are committed to creating an eco-friendly production process. Most of the plants that we sell at our markets are locally grown to reduce emissions during transport, but this is just one of several ways that we are striving to be good stewards of the earth.
The soil we use to grow our plants isn't soil at all. It is what our industry refers to as a "soilless growing media". At Bob's, we have our own custom-designed facility to produce exact recipes of growing mix. The three main ingredients of our growing mix are Canadian sphagnum peat moss, parboiled rice hulls, and composted pine bark.
Canada has over 270 million acres of peat bogs which produce peat moss. Each year the peat moss industry harvests only 40,000 acres of peat moss mostly for horticultural use. If you do the math that comes to one of every 6,000 acres of peat moss is harvested each year. And here is the best part, peat bogs are living entities. The peat bogs grow 70% more peat moss each year than is harvested. With that data, we believe peat is definitely a renewable resource.
Parboiled Rice Hulls (PBH) are a byproduct of the rice growing industry and are a readily available renewable resource. PBH, naturally, is biodegradable and, from our perspective, has the right physical size, shape and bulking properties to produce optimum air-filled pore space, water-holding capacity and drainage. Furthermore, PBH has properties that allows us to use less water. This also reduces fungus and pest problems in the greenhouse allowing for fewer fungicide and pesticide applications.
Carbon dioxide (CO2) is the primary gas responsible for climate change produced by modern technology. Plants naturally remove CO2 from the atmosphere by the process of photosynthesis. By producing the beautiful plants that we all enjoy, we are also offsetting our own carbon emissions created during the production process.
To further reduce our emissions, we have replaced many of our natural gas heaters with high efficient models that reclaim heat from the exhaust to make them 93% efficient. We have also installed heated floors in our newest greenhouses. By trapping and storing heat in the concrete floor, these newer greenhouses are much more efficient. Heated floors also eliminate the need for some seedlings to spend time in our germination rooms. This allows for less transportation of seedlings through the greenhouse which, in turn, saves energy and labor.
Light Emitting Diode (LED) lighting technology is further reducing our energy usage. We are currently experimenting with a number of light manufacturers to find the lights that best fit our growing needs. LED lights are approximately 75% more efficient than the high pressure sodium lights we have relied on for decades.
Here at Bob's we try to let nothing go to waste. One of the by-products of our production process is used growing media. It seems like we would have trouble disposing of this, but many of our employees are avid gardeners themselves. They "recycle" all of our used growing media at home in their own flower beds and gardens making beautiful, rich soil!
Like any business, we rely on both cardboard boxes and tons of paperwork. From boxes that seed, plant cuttings, and other supplies arrive in to sticky notes, inventory reports, and boring government paperwork, we are proud to say we recycle 100% of our cardboard and waste paper.
Each year we use nearly 1,000,000 plastic containers! If laid end-to-end, one year's worth of containers would stretch from our corporate headquarters in Mason, WV to our store in Atlanta, GA! To prevent this from going to landfills, we reuse or recycle all of our old plastic containers, cardboard, and many other materials. We would like to invite you to do the same. You can now bring any of your empty plastic containers back to your local Bob's Market for free recycling!


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The jaw crusher consists of a frame, eccentric shaft, big belt pulley, flywheel, movable jaw, side guard plate, toggle plate, rear seat of toggle plate, modulation gap screw, returning spring, fixed jaw plate, and a movable jaw plate. The jaw crusher is one of the most widely used primary crushers and is suited for materials that range from .
The jaw crusher is also called the jaw breaker. It has been widely used in many fields, such as mining, . When the movable jaw leaves the fixed jaw, .


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Legal (27) Apply Legal filter
Disorders (8) Apply Disorders filter
Experiments (7) Apply Experiments filter
Reproductive Health Arizona (4) Apply Reproductive Health Arizona filter
Displaying 126 - 132 of 132 items.
Clinica Para Madres (1934-1950)
The Clinica Para Madres (Mother's Clinic) opened in Tucson, Arizona, in December of 1934 as the first birth control clinic in Arizona. After moving to Tucson, birth control activist Margaret Sanger, along with a group of local philanthropic women, founded the clinic to provide Arizona women with contraception. During the early 1900s in the US, contraception was illegal under the federal Comstock Act. Additionally, many viewed contraception and sex as obscene and not to be discussed in public or outside of marriage.
Subject: Organizations, Reproduction, Outreach
China's First Baby Conceived through In Vitro Fertilization-Embryonic Transfer, by Zhang Lizhu's Research Team
On 10 March 1988, China's first baby conceived through human in vitro fertilization (IVF) and embryo transfer (ET), commonly referred to as a test-tube baby, was born at the Peking Hospital (PUTH) in Beijing. This birth was reported in numerous media reports as a huge step forward in China's long march to keep pace with global advances in science and technology. Led by gynecologist Zhang Lizhu, the PUTH research team had devoted more than four years to the human IVF-ET project.
Subject: Experiments, Reproduction
The Baby Doe Rules (1984)
The Baby Doe Rules represent the first attempt by the US government to directly intervene in treatment options for neonates born with congenital defects. The name of the rule comes from the controversial 1982 case of a Bloomington, Indiana infant Baby Doe, a name coined by the media. The Baby Doe Rules mandate that, as a requirement for federal funding, hospitals and physicians must provide maximal care to any impaired infant, unless select exceptions are met. If a physician or parent chooses to withhold full treatment when the exceptions are not met, they are liable for medical neglect.
Fetal Surgery
Fetal surgeries are a range of medical interventions performed in utero on the developing fetus of a pregnant woman to treat a number of congenital abnormalities. The first documented fetal surgical procedure occurred in 1963 in Auckland, New Zealand when A. William Liley treated fetal hemolytic anemia, or Rh disease, with a blood transfusion.
Subject: Disorders, Ethics, Reproduction
Mary Coffin Ware Dennett (1872-1947)
Mary Coffin Ware Dennett advocated for social reform in the United States in the early twentieth century, particularly regarding sex education and women's rights to access contraception. Dennett authored several publications on sex education and birth control laws. She also worked to repeal the Comstock Act, a federal law that made it illegal to distribute obscene materials through the US Postal Services.
Subject: People, Reproduction
Planned Parenthood Committee of Phoenix (1942-1978)
The Planned Parenthood Committee of Phoenix was established in 1942 to expand Arizona women's access to family planning resources. The Planned Parenthood Committee of Phoenix was formed through the merging of The Mother's Health Clinic in Phoenix, Arizona, with the national Planned Parenthood Federation of America. The clinic was primarily based within the Phoenix Memorial Hospital campus but expanded to other locations in the late 1960s.
Cocaine as a Teratogen
Cocaine use by pregnant women has a variety of effects on the embryo and fetus, ranging from various gastro-intestinal and cardiac defects to tissue death from insufficient blood supply. Thus, cocaine has been termed a teratogen, or an agent that causes defects in fetuses during prenatal development. Cocaine is one of the most commonly used drugs in the US and it has a history of both medical and illegal recreational use. It is a drug capable of a wide array of effects on physical and mental health.
Subject: Reproduction, Disorders


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Libri & Verbis
Traitor, Patriot, Sympathiser?
July 8, 2019 by Wayne No Comments
Punji Trap: Pham Xuan An: The Spy Who Didn't Love Us.
Author: Luke Hunt
Although the final shots were officially fired in April 1975 the Second Indo-Chinese war (the 'Vietnam War' to most) continues to yield stories and controversy, even as a growing number of its participants fade from the stage. Pham Xuan An is one such figure (An died in 2006). Born in southern Vietnam, An worked for the western press, filing copy out of Saigon for Reuters and, later, TIME, while clandestinely fulfilling his responsibilities as a communist sympathiser and agent – in short, a spy.
Luke Hunt is the latest writer to tackle An's story and legacy – and what a tale it is, An emerging from Hunt's book as, perhaps, the most significant figure of the Vietnam War that you have never heard of. And not just any man, for An was a figure around which many of the pivotal events and personalities of the conflict osculated. To help us understand An's character and motivations Hunt digs deep into Vietnamese history and the man's life, starting with An's childhood in the lower Mekong— including his years as a teenage guerrilla fighting the French—college years in California, his experiences in Saigon during the Vietnam War and, later, through the years that followed unification; until finally, with the turn of the final page, we see An's life for what it was – lived on the edge but at the centre of history.
However Punji Trap is more than a biography of one man, central to Hunt's book are a cast of wider characters—Vietnamese politicians and schemers (including the fearsome Madame Nhu), a coterie of colourful western journalists (Tim Page, Jim Pringle and Neil Davies) – even an Australian goose feather entrepreneur makes an appearance. The result is a volume that adds further colour and texture to the canvas of Vietnamese affairs during the most traumatic time in this country's history. A worthy addition to the cannon of Vietnam War-era writing, Hunt has done us all a service by updating An's story, while adding further clarity to the events that this enigmatic figure helped shape.
Luke Hunt: A word from the author –
How did you come to choose the story of Pham Xuan An as the subject for your second book? What things, in particular, attracted you to his story?
Actually, it was the first book I started and the last to finish. I was always fascinated by the Vietnam War, initially for personal reasons and later it became professional. I met people who knew the inside story of Pham Xuan An, particularly from the journalists perspective and began researching him when there was very little known about An for an undergraduate thesis in 1989. It grew from there and trips to Vietnam and many interviews with An, and those that knew him, followed. Most importantly was the manipulations of media perceptions about the battles fought, and how they were undermined by An, that was most enticing. The Vietnam War remains a very misunderstood conflict and Pham Xuan An is largely responsible for that and arguable the final outcomes.
Pham Xuan An has been the previous topic of a book—Larry Berman's Perfect Spy – The Incredible Double Life of Pham Xuan An—how does your story differ and add to Berman's account?
Those books came long after I began my research, which initially was clandestine. I think An will be one of those characters in history who will spawn many a book, and already there are others. The difference between my effort and other publications is that I did interview many of the people who worked closely with An, particularly in the newsrooms and especially people Pham Ngoc Dinh who worked with An at Reuters. Also other books have stayed close to Hanoi's official line, which is sometime oblique and does not always tally with what actually happened and how he worked. An was the top ranked spy for the communists and the nature of his business meant his entire professional life was spent in Western news rooms and not the corridors of power in Hanoi. It was the people on the ground in Saigon who had an understanding for what happened and they helped formed the basis for the Punji Trap.
You are doing a HOWL event [Ed. Cambodia's dedicated pop-up dedicated to celebrating and promoting the 'word'] on the 23rd of July, in Siem Reap. What can the audience expect from an 'encounter' with Mr. Hunt?
I'm never really too sure myself, it depends on the audience. These sorts of nights are nearly always unpredictable but often full of laughs. The online world has generated enormous interest in journalism and the wider media game and I've often found people are keen to know how it works — perceptions versus the reality — and hopefully they will take home a few thoughts that matter. I enjoy having questions thrown at me.
Otautahi, Christchurch, I am thinking of you.
'Three Women' Is this the 'book of the year'?
Looking for scribes . . . come join the pack
Luke Hunt – Postcards from the Edge
Death, survival and courage under ISIS
Book Bazaar: July 29th
Call of the Word


HERE'S WHAT MY CLIENTS ARE SAYING ABOUT ME…..
My new home is still a work in progress , but it is a happy one ! I am enjoying all of it despite the boxes still in my living room ! This journey has been made so much easier and fun with you as my guide . Your advice , calming influence , excellent research and knowledge have made selling and buying a new home a breeze!
In a period of almost a year since I met her, Peggy has helped me through three different real estate transactions: selling two different properties, on Sunshine Coast and Vancouver, and buying a property in Vancouver. Throughout that period, I found Peggy to be extremely hard working, thorough and professional. Her client's best interests always come first. Above all, her easy, relaxed personality and sense of humor made the whole process a lot less stressful. It was a pleasure working with her, and I highly recommend her to her future clients. Jelena G.


The last week of the year is ideal for an intimate, cosy river cruise. And there is nothing quite like visiting Europe during Christmas time. This post is all about why!
We first discovered the the Rhine River Cruise more than five years back. We found that it was the absolute best way to see the cities and towns of Switzerland, Germany, and France come alive during the festive season. Waking up in a different place everyday – breakfast in Basel, lunch in Strasbourg and dinner in Heidelberg kind of thing. It is all very exciting!
Most of us look forward to loads of pampering, chilling and shopping on a holiday. A Christmas and New Year Cruise offers both, and ensures that you'll fall in love with Europe all over again. The beautiful hues of red, white and green in every nook and corner is quite a sight to behold in Europe. The Christmas markets are treat to the eyes as they light up every street where locals welcome you to be a part of their celebrations.
What are the highlights on the trip?
From Basel in Switzerland the ship sails towards Breisach and Freiburg in Germany, towns which stock an array of gourmet food and wines, along with an impressive redstone Gothic cathedral. Later the ship heads towards France to dock at the medieval city of Strasbourg. Known for its black and white timber- framed buildings, ancient watchtowers, one unique thing about Strasbourg is, although it is in France, it has a visibly strong German influence. Riverside cobblestone streets, cafes and wine bars will enthrall you here.
Speyer and Heidelberg are our next two dockings. Speyer, is one of the oldest cities in Germany, well known for its cathedral and churches and even a 13th century gate tower. While Heidelberg is home to the oldest university of Germany. A tour of Heidelberg is incomplete without paying a visit to the red walled castle and its Great Vat, a 49,000 gallon 18th century wine cask. The cafes in Heidelberg are very friendly and you can be assured of ample clean and good loo facilities, irrespective of whether you are dining there or not. The shore excursions as they are called are among your number of inclusions, but do remember to dress very warmly in layers when you step outside the temperature controlled cabin and ship. Invariably a glass of hot mulled wine or hot chocolate welcomes you back on board after your day's time out.
After an enjoyable lunch on board, the ship meanders through the Rhine Gorge, with awesome picturesque views of the Rhine valley, interspersed with little houses and vineyards. Our penultimate stop over is Cologne. The popular Cologne cathedral is a must see must do. Walk through the city railway station to enjoy distant views of the iconic cathedral and watch out for the street musicians and bands – Cologne is quite the place for a touch of jazz, .
From visiting traditional Christmas Markets, indulging in the festive shopping to tasting gingerbread and mulled wine, this cruise holiday will be a perfect gift to yourself.
Sumitra Senapaty is the founder of The WOW Club. She logged thousands of miles around the world as a wanderer, culminating with the creation of the WOW Club travel platform for Women.
Why should Croatia be on your bucket list?
Q&A: Simple way to visit Jordan & Israel together?


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Good financial decisions will ensure SA agriculture's survival during bad times
Dmitry Pichugin via Fotolia
According to the latest economic growth figures released by Statistics SA, agricultural sector production expanded by 13.1%. The sector has hit the reset button and after almost two gruelling years the sector is nearly back to normal.
The outlook for 2021 remains positive with favourable weather conditions and strong international demand for agricultural exports that will continue to support production growth.
South Africa's agricultural sector was one of the only shining stars in the economy in 2020, escaping the effects of the Covid-19 pandemic relatively unscathed, with the exception of some industries e.g. wine, hunting and tobacco…
Dawie Maree, head of information and marketing at FNB Agriculture, says producers now have room to reduce debt. They can even consider expansion again.
The country experienced a record export crop for citrus – up 35% in 2019 – topping R26.6 billion last year. "We have good maize and oilseed crops in the ground with excellent prices.
Good crops and good prices
Maree says it is not a common occurrence to have a large crop and good prices in one year. In normal circumstances, prices are driven down when there is sufficient supply in the market.
Commercial maize for 2019-'20 increased by 36% year-on-year to 15.3 million tonnes.
Maize prices for 2020 remained at high levels of R3,400 per tonne. Current estimates indicate a potential crop north of 16 million tonnes for the 2020-'21 production season.
Oilseeds, sunflower and soybean crops increased by a whopping 16% and 6.4% respectively year-on-year at 788,500 tonnes and 1.25 million tonnes during the 2019-2020 season. Prices reached record levels of R10,000 per tonne for soybeans and just over R9,000 per tonne for sunflower.
Maize export demands from countries, mainly China, increased last year as a result of supply chain disruptions caused by the pandemic. Production limitations in the US due to drier conditions resulted in higher corn prices which filtered through to our maize price.
During the 2020-2021 marketing season maize exports increased by 93% year-on-year from 1.16 million tonnes to 2.24 million tonnes. Prices remain elevated above R3,000 tonnes for all maize types.
SA also experienced increases in export demand from our neighbouring countries, notably Zimbabwe where our maize serves as a food source.
Bucking trends
The livestock sector remained resilient, despite the Covid-19 regulations that saw the temporary closure of restaurants and the hospitality industry. Meat products destined for the local market were exported, supporting prices at relatively high levels, says Maree.
Demand for meat in the local market also remained relatively strong. "This bucked the trend. One would expect that during tough times meat consumption would be affected, putting downward pressure on prices. However, prices remained relatively stable and even strong for some meat categories," says Maree.
At producer level, beef prices are on average 10% higher year-on-year, 15% higher for sheep and pork and poultry is marginally higher at 5%.
SA had a good year for the production of cattle, sheep and small livestock such as goats. Livestock was able to graze following the good rainfalls. This reduced producer's feed costs.
Maree says farmers were holding on to their stock to improve their conditions before sending them to the slaughter market. At consumer level, the latest meat price inflation for January 2021 is up 7.2% year-on-year.
Farmers with intensive livestock feeding systems, feedlots, poultry operations and piggeries experienced some margin squeeze, mainly because of maize prices. Grain (maize and soya) makes up around 70% of livestock feed. Fortunately, livestock prices remained relatively strong, cushioning producers against excessive margin squeeze.
However, the reality is that bad times will come around again. Maree says when it does arrive financial survival rests on two main pillars – proper financial and production management.
This entails proper asset management practices, building up financial reserves during good times and proper succession planning.
Maree's advice is to invest in "productive assets" that can be used in farming operations, and to factor in the possibility that interest rates may rise again. It may be quite tempting, but a new top of the range pickup is not an income-generating investment. "We have a fairly old fleet of tractors and farming equipment in SA. Now, may be a good time to do some replacements."
Interest rates are still favourable for these acquisitions.
Livestock farmers may consider investing in the expansion of their herd; grain farmers may consider investing in a livestock arm of the business.
"SA's farmers are getting older, and although there is a good 'crop' of new farmers entering the market the hand-over and the succession from the father to son is crucial." The average age of South African farmers is estimated at 62.
Maree says tax planning is crucial as it enables the farmer to make the right investment and expenditure decisions.
Diversification is not simply a buzz word in the agricultural sector. It is crucial for financial survival.
This entails diversification on-farm, in the same district, in other geographical areas and in different product ranges. Farmers may even consider investing in, for example, a packhouse to increase their footprint in the value chain.
The most extreme form of diversification is to exit primary agriculture and invest purely in a manufacturing plant. "All of this could offer a solid foundation for survival in tough times," says Maree.
Adding value will cushion the shocks during turbulent times. The citrus farmer may invest in his own packhouse, or add more value by tweaking marketing and distribution strategies.
Livestock farmers may opt to improve the genetics of their animals when engaged in stud farming, or they could become a partner in an abattoir or a butchery.
"Farmers who are successful in their diversification are getting more of the consumer-rand back into their own pocket." Resilience, agility and flexibility are the cornerstones of robust financial and operational management practices.
Risks that remain on the horizon include expropriation without compensation, the imposition of non-tariff barriers to trade such as export bans and geo-political tensions, notably between China and the US.
APPOINTMENT ANNOUNCEMENT
Marel's 1000mm low-pressure forming machine is here!
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Donors pledge $30 billion for Africa's agriculture
AFEX Expands Operations To Uganda, Appoints Group CEO and Presidents


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Executive Salaries are Creeping Back Up
October 7, 2011|Compensation/Incentive Programs, General HR
Kansas City, Kan. — With protestors marching on Wall Street and the gap between the upper and middle class rapidly increasing, executive salaries continue to be a point of consternation for most Americans. Although most executives were not immune to the effects of the sluggish economic climate, salaries for many executives are now trending back up. The Executive Compensation 2011/2012 survey results found the average base salary for a CEO is $338,300 per year. This reflects an increase of 1.6 percent since 2010.
CFOs have seen their pay increase by 1.7 percent to $201,800. Presidents are earning $248,600, up from $241,900 in 2010. The salary for treasurers averages $172,600, representing a 2.7 percent increase. Vice presidents are earning 2.1 percent more than they did last year.
"Though salaries for most executive jobs have begun to rebound, a few still have not yet reached levels seen prior to the recession," said Amy Kaminski, director of marketing for Compdata Surveys, the nation's leading pay and benefits survey data provider. "Companies may be increasing executive salaries in preparation of an economic turnaround, but most are taking a very cautious approach to those increases."
Company size is an important factor when determining executive pay. Presidents at companies with 1,001 to 5,000 full-time equivalents (FTEs) earn $294,600 each year, compared to those with 501 to 1,000 FTEs, $278,900. Companies with 201 to 500 FTEs pay presidents an average of 256,900, annually. Presidents earn $216,800 at organizations with 101 to 200 FTEs, while those with fewer than 100 FTEs receive $200,300 per year.
Salary differences are also found between industries. Treasurers, for example, earn an average $193,400 at healthcare organizations, while those in the hospitality industry earn $188,700 each year. Banking and finance organizations pay their treasurers $177,500, while those in utilities earn $171,600. Salaries for treasurers in the not-for-profit industry average $154,200.
Executive Compensation 2011/2012 analyzes national and regional data by base pay and total cash compensation for more than 65 executive and senior management positions. Information was collected from more than 4,500 organizations across the country, reporting on over 22,000 incumbents.
Compdata Surveys is the nation's leading compensation and benefits survey data provider. Thousands of U.S. organizations provide data each year ensuring the reliability of our results. Compdata Surveys has been providing comprehensive data at affordable prices to organizations from coast to coast since 1988. For further information about their compensation and benefits surveys, contact Michelle Willis at (800) 300-9570.
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