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I don't even know how to sum up this year.
If I'm honest, most of it's blurry. The first half of it anyway. I was still trying medication after medication so I was kind of living in a haze. It's scary to look back at a time not that long ago, search for memories and not be able to find them, find the details. Or worse, not even know what memories to look for. I hate it and it's scary and I try not to think about it. Thank god for photos though. Looking back through my photos helped me to remember and I'm grateful for that.
I got to go to the opening night of Waitress The Musical and to my complete surprise, Sara Bareilles was there, both to introduce the show and to bid us all goodnight. The show was amazing: I loved the music, I loved the characters, I loved the story, and the meaning in the story. And seeing Sara Bareilles in person for the first time since 2014 was extra special.
I also got up stupid early to see her do a surprise set in St Pancras station. Apart from the fact that she has an incredible singing voice and is a great performer, even just sitting at a piano, there's something magical about seeing a person you admire so much in real life. And my Mum was a trooper, running after her team (my medication meant I could barely stand up for the whole performance) and making sure she got my letter. So that was a good morning, even if I felt very unwell for the rest of the day (I'd overstretched, given the meds I was taking).
We had a nerve-wracking few weeks where our dog, Lucky, was incredibly unwell. I saw it happen: his head just tilted to the side and he stood there, looking so… wrong. I was convinced he was having a stroke. Plus his eyes were moving back and forth really quickly; I couldn't imagine how he could even see. Despite a trip to the emergency vet then and there, we didn't find out until the next day that he had Geriatric Vestibular Disease, which is basically vertigo. He was really, really sick. He wouldn't eat and that's really the sign that a labrador is sick. Mum was feeding him pieces of boiled chicken by hand just to keep him going. They gave him a morphine patch but that just made him sicker so they eventually removed it. It took a long time but eventually he was back to his old self. It's not the same: he has a permanent head tilt, his balance is terrible, he can have trouble walking. But he seems to be happy and he's certainly loved. So we're getting through. Day by day, we're getting through.
I was fortunate enough to go to Nashville again, which was amazing, even though I was really, really struggling on my medication. I was depressed, overwhelmingly anxious, and my hands felt thick and clumsy, making playing guitar a real ordeal. As wonderful as it was to be in Nashville, I felt very guilty for not being as happy as I felt I should be.
Having said that, I had some really great experiences while I was there. I got to go back to my favourite places, see two Song Suffragettes shows (which are always such special experiences for me), and hang out with my friends who I only get to see once a year. I didn't get to see everyone but I had a lovely time with the people I saw. I even got to see the awesome Caylan Hays play a show and hear all of her new songs. That was really, really special.
Tin Pan South was amazing as usual, although I had to make some tough decisions over which shows to go to. They were all amazing though. My favourite was Nick Wayne, Hannah Ellis, Josh Kerr, and Natalie Hemby. Natalie is another person I hugely admire and she actually knows who I am now, which I'm honoured by. We got to have a proper conversation, which was one of my favourite moments of the trip. And I'd love to write with her one day: that's a bucket list write.
I also got to see Kelly Clarkson (who I've always, ALWAYS wanted to see live) in concert and Kelsea Ballerini was the opener, which was awesome because I love her. It was an amazing concert and I loved every second of it.
It was an amazing trip but I hope that next year I'll be in a better place, a place where I can enjoy it properly and effortlessly. I think that's gonna be one of my goals for 2020.
Here at home I also got to see some amazing concerts. My favourites were Maren Morris (I saw her twice but the second time was front row at the Royal Albert Hall, which was the most surreal, amazing experience) and Ingrid Andress, who had the whole crowd singing despite only having released a few singles. It was amazing. And she remembered me and we talked about writing together when I'm next in Nashville, although I'm now not sure it's going to happen. But it was amazing to know that she was up for it. Hopefully one day.
I also saw Halsey in a super small venue and she was fantastic. We had trouble with the accessibility, which caused me a lot of anxiety, but the show was incredible. She's an amazing, amazing performer. I love her. But I feel very out of place at her concerts, which is hard.
I, with Richard Sanderson (Richard Marc on social media), spent most of the year working on my first EP. It was such a learning curve but I loved it, for the most part. It took an exceptional amount of work and I have to give so much credit to Richard and to Josh Fielden who mixed the songs because part way through, I tumbled into a really deep depression, accompanied with the worst anxiety I think I've ever experienced. It took a long time for me to get back to a place where I could work on it. It's part of my musical story so I'm really glad it's coming out, even if I still have a lot of anxiety about it. If you've been following this blog, you'll know the story of the first single and you'll know more about the rest of the songs soon.
I spent several months in a deep, deep depression, the worst I've ever experienced. I basically lay on the sofa and thought about dying. It was awful. I don't really know what else to say about it. It was just still, but with a mess of agonising turmoil underneath.
Then, in the middle of the summer, one of my cats had kittens, despite the vet telling us in her vet check the week before that she absolutely wasn't pregnant. We came home from dinner and Mouse was waiting for us. She took me upstairs to my room, curled up in one of the cat beds, and over the next few hours, she had a couple of tiny, adorable kittens. She got distressed every time I tried to leave so I stayed through the whole thing (and saw some pretty disgusting stuff that I never needed to see).
Having the kittens in my life has done wonders for my anxiety. Watching them grow and play and explore was so calming and mindful for me. And now that they're older, all five cats play as a family. They're a pride. It's gorgeous. I don't know what the future holds but having them in my life has been one of the most, if not the most, positive thing this year. I'm really, really grateful for them. Having said that, everyone's spayed now so there won't be any more surprises, which is probably – definitely – a good thing, as adorable as kittens are. The stress is just too much.
Somewhere in the middle of the holidays of kittens, I started taking Phenelzine again, which was a really difficult decision. I'm still struggling with the side effects but I am better than I was. I still have moments of depression but it's not constant and I'm managing the anxiety with other medications. And best of all, I can write songs again. That is the best possible outcome.
September loomed and I spent time with the Disability Coordinator at my uni, something they had never had before. I actually felt hopeful about having someone who understood me. And then, she became extremely unreliable and that resulted in one of the worst meltdowns I've ever had – in the middle of Victoria Station. That triggered a period of multiple meltdowns a day, which turned the weeks into a blur. It was awful. I started my Masters Degree in Songwriting in one of the worst states I've ever been in.
Despite being part time, the Masters took up every day of the week, working on songs and trying to research while battling my OCD, which had suddenly spiked. I had no time off, no time to breathe. I felt like I was failing at everything. I think I've gotten better at managing it (and it's going to be a focus in therapy when we start again in the new year) and I managed some research and I wrote some songs I'm really proud of. I enjoyed the course and classes but balancing everything with Autism and mental health problems was a nightmare. I'm going to write a post about the course in more detail but it still needed to be included in this post.
Oh, and somewhere in there, I turned twenty five. My Mum bought me twenty five yellow roses.
The first single of the EP came out a few weeks into the course and it was a complete surreal – if incredibly stressful – experience. I had no idea what to expect, especially since I'm an independent artist, but for what was really a first, first single (considering 'Invisible' had no marketing and so on), I think it did pretty well. It got added to several playlists on Spotify and had radio play, local and BBC Introducing. That's been amazing and I'm excited to see where the next one goes.
And now I'm finishing the year with basically no Christmas break because I'm working on the assessments for my course everyday. They're causing me so much stress I feel like I can't breathe. I'm also terrified of the fireworks tonight (another story I've talked about before) and don't know what I'm going to do to avoid them because I have work to do and they cause awful meltdowns. So, all in all, not the best way to end the year. I'm cautiously optimistic about 2020.
"2019 has been an incredibly difficult year. I feel broken. I feel like I was shattered into a thousand pieces and then put back together wrong. And if I'm honest I don't know what to do about it. But there were good moments too and I'm so grateful for those. 2020, please be kind." (x)
Category: about me, animals, anxiety, depression, diagnosis, emotions, holidays, medication, meltdowns, mental health, ocd, suicide, therapy, treatment, university Tagged: 2019, 2019 in review, 2020, antidepressants, anxiety, bad night, birthday, cat, caylan hays, concert, debut ep, depression, dog, halsey, ingrid andress, kelly clarkson, kelsea ballerini, kitten, kittens, maren morris, masters, masters degree, masters degree in songwriting, medication, meltdown, meltdowns, mental illness, nashville, natalie hemby, obsessive compulsive disorder, ocd, phenelzine, reflection, richard marc, richard sanderson, sara bareilles, song suffragettes, songwriting, suicidal, tin pan south, university, waitress the musical
BEHIND THE SONG: Bad Night
This week, I posted a video telling the story behind the song of 'Bad Night,' the experience that inspired it, the writing of it, the recording of it… I posted it on all of my social medias but I also wanted to post it because the song is about my experience with depression – or at least one night of it – and so I feel like it's relevant here, like it might connect with you guys. I hope you like it.
If you haven't heard the song yet, you can find it here and if you want to see the music video, you can find that here.
I'm drowning in work for my Masters but I'm hoping to post on Saturday. Hopefully see you then.
Category: depression, mental health, music, video Tagged: bad night, behind the song, bts, depression, honest, honest ep, mental health, mental health awareness, mental illness, recording, single, songwriting
Reactions to 'Bad Night'
So, since 'Bad Night' has gone out into the world, there have been some really positive reactions and I'm really, really grateful and excited so I thought I'd share them here. It's been added to playlists on Spotify and PLAYED ON THE RADIO, both of which are just so exciting. While I think we, as artists, all have daydreams of a song going out into the world and being a huge hit and bringing everything we've ever wanted to our door, realistically we know that that's very unlikely. But this song has gone out and cool things have happened, especially for being only the second song I've ever released.
It's been added to a couple of playlists, as you can see here. A super special shout out to Song Suffragettes for their constant support; I feel very lucky to have connected with them. And I'm grateful to FutureNectarSounds for taking the chance on me and adding me to their playlist.
And I got my first radio play, on Cambridge 105! Richard, my cowriter and coproducer, lives near Cambridge, hence the connection. That was very exciting, even though I didn't get to hear it and I'm really grateful to them for playing it. I'm also currently on their Unsigned Chart, which is very cool. If you go to their site, you can vote for me and help me stay in the chart, maybe even get higher!
I haven't had a phone this week so I haven't been able to post the cool 'Bad Night' things that have happened. Thank you FutureNectarSounds and @songsuffragettes (I love you guys!) for adding it to your playlists and @cambridge105 for playing it. I'm so, so grateful!
A post shared by Lauren Alex Hooper (@laurenalexhooper) on Oct 27, 2019 at 3:31am PDT
As many new artists do, I uploaded the song to BBC Introducing. I've done this before but never received a response. But this time, I got an email from the host of BBC Introducing South, asking if I had a radio edit as the song in its original form is quite long for a pop song. We quickly created one, uploaded it, and they decided to play it. I'm not kidding: I totally freaked out. This is something that's been on my musical bucket list ever since I really started working toward releasing my music. As you can see, I was pretty excited…
I AM FREAKING OUT GUYS! 'Bad Night' will be on @bbcintroducing / @bbcintrosouth tonight between 7-9pm.   I'm so excited. This is something I've been dreaming about for years 💜  You can listen on @bbcsounds or on the radio: Brighton on 95.3 FM / Sussex & Surrey 104-104.8 FM
A post shared by Lauren Alex Hooper (@laurenalexhooper) on Nov 6, 2019 at 3:11am PST
And this was my reaction to actually hearing it:
Being played on @bbcintroducing is something that I've dreamed of for years, as I wrote songs, grew as a writer, and figured out what I wanted my production style to be. And tonight it finally happened. Thank you @bbcintrosouth and @melitadennett for giving me this wonderful moment.
A post shared by Lauren Alex Hooper (@laurenalexhooper) on Nov 6, 2019 at 1:15pm PST
I'm really grateful to BBC Introducing South for giving me this opportunity and this special moment.
And amazingly, they played it again a couple of weeks later. Again, I'm so grateful for the opportunity and it's amazing to feel like the song is moving out into the world.
GUYS! @bbcintrosouth are being super awesome and playing 'Bad Night' AGAIN tonight 7-9pm so please listen/text/tweet in! I will love you forever!   You can listen to it here: Listen in Brighton on 95.3 FM Listen in Sussex & Surrey 104-104.8 FM Or from anywhere on @bbcsounds  Personally I find it easiest to listen live on the BBC Sussex website.   (It may also be being played on RadioReverb on Thursday 5-6pm too!)
A post shared by Lauren Alex Hooper (@laurenalexhooper) on Nov 20, 2019 at 5:03am PST
It was also played on Radio Reverb, which was really cool, especially as it's a local, Brighton radio station. My town was playing my song. That made me really happy.
I did an interview with my university, ICMP (The Institute of Contemporary Music Performance), which was cool, although I can get very anxious about answering the questions the 'right' way, saying the 'right' things. But I think I did okay. You can find it here. I hope you find it interesting!
And finally, the music video had a really lovely, beautiful review from Indigo Eve Music, which you can read here.
I hope some of this was interesting to you. This blog is about following my journey, in music as well as mental health and Autism. I promise there will be more of those posts soon. There's been a lot of stuff going on, so much that I haven't had time to write about it so I'm looking forward to updating the blog and you guys.
Category: music Tagged: bad night, bbc introducing, bbc introducing south, brighton, brighton radio, debut ep, grateful, honest, honest ep, icmp, interview, local radio, new music, new single, radio play, radio reverb, radioreverb, spotify plalist, the institute of contemporary music performance
'Bad Night' Music Video – Out Now!
So, again, I'm terribly behind in letting you guys know about my latest musical endeavour. I released the music video for 'Bad Night' on Wednesday 13th November. Here it is and I hope you like it:
Despite being the central person in the 'Invisible' music video, I'd never done anything like this before. I'd never destroyed a room before (which was way more physically exhausting than I expected since you have to do everything about three times to get the right shots but also multiple times because breaking things isn't as easy as it looks and I kept messing up). I'd never done a 'performance part' of a video, if you know what I mean. I felt very awkward and very overly aware of all my limbs. Oh, and my facial expressions. It was all very new and strange. There were moments where I felt like I was getting it but they were few and far between. Most of the time I felt like I was about two seconds from falling on my face. It was a mix of fun and stressful and exhausting and satisfying.
After the video came out, I posted little behind the scenes videos or photos on social media:
1. Cold, cold, cold.
Standing on top of a car park to film a music video on the coldest night of the year so far may not have been the smartest idea I've ever had. #BadNightBTS
A post shared by Lauren Alex Hooper (@laurenalexhooper) on Nov 15, 2019 at 10:34am PST
2. As I said, I felt very aware of my limbs.
I felt like a very awkward antelope throughout this whole shoot 😝 #BadNightBTS
3. "This is why I've never played sports."
I may have had some trouble with some of the stunts… #BadNightBTS
4. Planning some of the shots…
Some of the more technical discussions going on during the outdoor shoot… #BadNightBTS
5. Siri clearly wanted her moment of fame…
Technical difficulties, you might say… #BadNightBTS
A post shared by Lauren Alex Hooper (@laurenalexhooper) on Nov 23, 2019 at 12:33pm PST
6. I'm pretty proud of the chaos I created.
I don't think I did too badly at destroying my bedroom… #BadNightBTS
7. We were cold and tired but very proud of ourselves.
Last #BadNightBTS… After hours in the freezing cold, we decided to call it a night, that we had enough footage. Swipe to see our delirium at finishing all the filming for the video.
So there you have it. I'm so proud of this video and am so grateful to work with Richard. He's such an amazing friend and an amazing photographer and videographer (his website is here). It was a massive jumble of emotions and was really, really hard at times but it's exactly what I wanted for the song so I'm really, very proud of it.
Category: music, video Tagged: bad night, badnightbts, behind the scenes, bts, debut ep, filming, honest, honest ep, lauren alex hooper, laurenalexhooper, music, music video, new music, singersongwriter, singersongwriter life
I'm very late in letting you guys know but my new single, 'Bad Night,' is now available to buy/stream/listen to in whatever format you listen to music to!
laurenalexhooper: AND IT'S OUT! 'BAD NIGHT' IS FINALLY OUT!
I've been waiting to release this song for so long that it's oddly surreal to have it out in the world. I wrote it, with the help of @richardmarcmusic, after a particularly difficult night where I just felt completely overwhelmed by my depression. I felt like it was never going to get better. So I do what I always do and wrote a song about it. And eventually it turned into this. Even though it's a difficult song, I hope you like it and I hope it makes you feel something.
Please, please, please buy/stream it. It would mean the world to me and all the wonderful people who've worked on it. You can find it here.
I'm truly sorry that it's taken me so long to update you guys. After the whole process of 'Invisible,' I (and my writing/releasing/everything musical partner) decided to release the song independently and I found all of the aspects of that very stressful. So getting the song out was a mission in itself and then there were the decisions about what social media boosting to employ and it all just took every ounce of everything I had. By the end of that week, I was completely exhausted. And let's not forget we were both just starting our Masters Degrees.
And then, to make things worse, I had possibly the worst Autism/mental health week of my life (just so you know, I sometimes combine them because I find them hard to extricate, not because I don't know that they're not the same thing). As I mentioned in my previous post, I've been having A LOT of meltdowns. It had come down to a couple a week but then I had week where I had multiple a day and it was just hideous. I'll write more about it (hopefully) and meltdowns in general in the future but that put 'Bad Night' the furthest from my mind for a moment.
It's hard to believe that it's only been about two weeks since the song came out. It feels like a lifetime. But having said that, the journey is far from over. There is a lot of content still to come. A spoiler for you special people: keep an eye on my socials over the next couple of days. Something is coming… Okay, that sounds a lot creepier than it is.
I promise this blog won't become simply an avenue for me to talk about my music (although much of my music is inspired by my mental health and so does have some relevance). It is just a massive part of my life right now, taking up a lot of my time and focus, as is my Masters, which is also all about music. I'm trying to find a balance but I'm struggling since my mental health has been so bad. I'm barely (and sometimes not) getting done what I need to be getting done so it's all very chaotic and emotional and difficult right now. Just know that I'm trying my best. I'll get there, I promise.
Category: anxiety, autism, emotions, event, meltdowns, mental health, music, university Tagged: anxiety, autism, autistic meltdown, autistic meltdowns, bad night, honest, honest ep, meltdown, meltdowns, mental health, mental illness, my music, new music, new music uk, new single, single release


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DOC Physicians Realty Trust
Materials : Chemicals |
Based in China
Muliang Viagoo Technology Inc, formerly Muliang Agritech Inc is a China-based company principally engaged in the manufacturing and distribution of organic fertilizer and the sales of agricultural products. The Company is engaged in the processing of crop straw (including corn, rice, wheat, cotton, and other crops) into organic nutritious fertilizer rich in small molecules. The Company distributes organic fertilizer products under its brand names Zongbao, Fukang and Muliang. The Company is also engaged in growing and selling agricultural products such as apples and providing logistics services.
October 29, 2019 3:02pm ET
Udemy Experiences High Growth Across Asia-Pacific Region and Melbourne Hub
5:00 pm ET November 8, 2022 (Globe Newswire) Print
Udemy Experiences High Growth Across Asia-Pacific Region and Melbourne HubGlobeNewswireNovember 08, 2022
MELBOURNE, Australia, Nov. 09, 2022 (GLOBE NEWSWIRE) -- Udemy (Nasdaq: UDMY), a leading destination for learning and teaching online, today announced Melbourne as its regional business hub in Australia, signaling further investment in growing its presence in the Asia-Pacific (APAC) region.
Udemy's platform serves nearly one million learners in Australia with flexible and effective skill development education. In addition, Udemy's workforce in Australia has grown by more than ten times since 2019 - with a continued focus on hiring top talent in the remainder of 2022 and beyond. In June 2022, Udemy Business, its corporate training solution, saw around 50% growth in learners across new and existing customers in Australia, New Zealand, and other APAC markets, when compared to a year earlier.
"Australia and New Zealand are key markets for us, and a central business hub in Melbourne will support the continued expansion of our business across the region," said Peter Kokkinos, Vice President and Managing Director of Udemy APAC. "Now more than ever, reskilling and upskilling are imperative for companies to stay ahead of the ongoing changes and disruptions across industries, and we are here to help our customers meet these challenges."
Udemy Business supports Australian enterprise customers with personalized and scalable employee skill development solutions as more organisations invest in building cultures of learning at work. It currently serves Australian companies such as Australia Post and P&N Group. Other APAC customers include Bosch Global Software Technologies Company Limited, LG Uplus Corp, Hyundai Mobis, Mitsubishi Chemical and many others.
"In a landscape highly affected by economic uncertainty and disruptions, especially over the last two years, Udemy is focused on our mission to improve lives through learning. We offer a wide variety of high-quality courses on trending topics taught by real-world experts and empower our customers with distinctive learning experiences for their employees," said Marlon Herft, Senior Director and Head of Customer Success of Udemy APAC.
Fueling the success of Udemy Business is the company's vibrant consumer marketplace, with more than 57 million learners globally accessing 213,000 courses from 74,000 real-world expert instructors teaching across more than 75 languages. Udemy has seen impressive growth internationally with 4.4 million new learners across 187 countries - a 38% increase in 2021 alone. The company is also powered by the industry's most dynamic and agile content engine with 4,800 courses added monthly - and 3,000 new instructors joining the platform in the last quarter.
Udemy was founded in 2010 with the mission of improving lives through learning. The company is now one of the world's leading online learning platforms with over 773 million course enrollments worldwide.
Udemy Business offers an International Collection with localized learning experiences across 14 languages - English, Arabic, Brazilian Portuguese, French, German, Indonesian, Italian, Japanese, Korean, Mandarin, Polish, Russian, Spanish, and Turkish - removing the need for dubbing or subtitles and thus, enabling in-depth understanding with local context. In total, Udemy Business has deployed 8,300 courses in English and 10,800 courses in 13 additional languages.
Udemy (Nasdaq: UDMY) improves lives through learning by providing flexible, effective skill development to empower organizations and individuals. The Udemy marketplace platform, with thousands of up-to-date courses in dozens of languages, offers the tools learners, instructors, and enterprises need to achieve their goals and reach their full potential. Millions of people learn on the Udemy platform from real-world experts in topics ranging from programming and data science to leadership and team building. Udemy Business enables employers to offer on-demand learning for all employees, immersive learning for tech teams, and cohort learning for leaders. Udemy Business customers include Fender Instruments, Glassdoor, On24, The World Bank, and Volkswagen. Udemy is headquartered in San Francisco with hubs in Ankara, Turkiye; Austin, Texas; Boston, Massachusetts; Mountain View, California; Denver, Colorado; Dublin, Ireland; Melbourne, Australia; New Delhi, India; and Sao Paulo, Brazil.
Risha Tyagi
Global PR Manager
press@udemy.com

redpajama_set_name: RedPajamaCommonCrawl


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So it looks like Kristy Lee Cook was as �clever� as Simon said to sing �God Bless the USA.� Of course he can�t bash a patriotic American song � he�d get mauled by the already unstable girls in the front row. That chick has fans somewhere who are keeping her going. I�m happy for them that she made it to the top 10 and on the summer tour. Now it�s time to start thinking of others!
As Paula said, someone�s going to have to leave every week. I love Chikezie but he had to get out of the way before the top three � the Davids and my fave Carly � battle it out for number one.
I still want Randy to explain how David Cook is the �most original, the most bold contestant we�ve ever had� when he�s consistently copied the creativity of others.
Maybe they�ll post that question on the big screen next week.
Gina Carbone thinks Syesha will be out next week because she has more talent but fewer fans than the ditzy dread-head. E-mail gcarbone@seacoastonline.com.


If you haven't tried out Blends, the alcohol markers by Stampin' Up!, you are missing out. These markers are amazing. My favorite feature of Blends is that they don't leave "lines" when coloring. The colored images turn out beautiful. I have added a video below showing how you can use the Color Lifter to add an even more "experienced" look to your projects. It also shows you how to use the markers to create authentic skin tones.
If you want to learn more about Blends, just CLICK HERE. Blends are available in my ONLINE STORE. Have questions? Feel free to contact me. I am "at your Serviss".
If you love this Happy Wishes stamp set, you are going to love it even more when I tell you how you can get it FREE!! During the months of January, February and March 2018, Stampin' Up! offers its best promotion of the year...Sale-a-Bration (otherwise known as SAB). In the past, it has always been a time when customers could earn free product with every $50 purchase. This year, however, Stampin' Up! has upped their game and now offers a few "higher tier" items. Now when you spend $100, you can elect to receive two "regular" SAB items or one "higher tier" item like the Happy Wishes stamp set. How sawesome is that??
If you'd like to receive this stamp set for FREE, just place your online order for $100 HERE and choose the Happy Wishes stamp set, when prompted. If you have any questions, feel free to contact me. As always, I am "at your Serviss".


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Amgen Awarded Breakthrough Therapy Designation
Acquisitions, Amgen, Breakthrough Therapy Designation, Business, Clinical Trials, FDA, Fibroblast Growth Factor Receptor (FGFR) Inhibitors, Gastric Cancer, R&D
Amgen Awarded Breakthrough Designation for Acquired Cancer Antibody Drug
By Alex Keown
One month after snapping up Five Prime Therapeutics and its Phase III ready anti-FGFR2b antibody bemarituzumab for $1.9 billion, Amgen announced the U.S. Food and Drug Administration (FDA) awarded Breakthrough Therapy Designation to the asset as a first-line treatment for certain types of gastric cancer.
Late Monday, Amgen announced the investigational drug bemarituzumab received the FDA's designation for patients with fibroblast growth factor receptor 2b (FGFR2b) overexpressing and human epidermal growth factor receptor 2 (HER2)-negative metastatic and locally advanced gastric and gastroesophageal (GEJ) adenocarcinoma. The designation was based on data from the Phase II FIGHT study in frontline advanced gastric or gastroesophageal junction (GEJ) cancer. Data from the study, announced in November 2020, shows all three efficacy endpoints of progression-free survival, overall survival and overall response rate were met.
Amgen R&D Head David M. Reese said the FIGHT trial is the first study that evaluated targeting the overexpression of FGFR2b in cancer. He said bemarituzumab as a front-line therapy demonstrated "clinically meaningful outcomes" in those three key endpoints in patients diagnosed with advanced gastric or gastroesophageal cancer. He added the company looks forward to moving bemarituzumab into Phase III and is already discussing potential paths to approval with various regulatory bodies.
It is estimated that more than one million new cases of gastric cancer are diagnosed annually, particularly in Asia, where the disease is more common. Amgen expects to see that area become an important market for medications like bemarituzumab. In preparation for potential marketing of bemarituzumab, Amgen said at the time it acquired Five Prime that it will leverage its presence in Japan and other Asia-Pacific markets to maximize bemarituzumab's potential. Amgen said that approximately 80% to 85% of patients with advanced gastric and GEJ cancers are HER2-negative. Also, it is believed about 30% of these patients present with FGFR2b overexpression.
Michael Vi/Shutterstock
Bemarituzumab targets FGFR2b, which is overexpressed in approximately 30% of patients with non-HER2 positive gastric cancer, as well as other solid tumors. As BioSpace previously reported, additional analysis from the Phase II study showed a positive correlation between efficacy and expression of FGFR2b on tumor cells, confirming both the importance of the FGFR2b target and the activity of bemarituzumab against this target. In its announcement this morning, Amgen said that correlation suggests that FGFR2b could play a role in other epithelial cancers, including lung, breast, ovarian and other cancers. The Breakthrough Therapy Designation was granted based upon a subset of patients who showed at least 10% of tumor cells overexpressing FGFR2b.
The FDA's Breakthrough Therapy Designation is critical to companies as it expedites the development and regulatory review of investigational drugs that may have the potential to demonstrate substantial treatment improvement over available medicines. For Amgen, the designation awarded to bemarituzumab is the second oncology asset in its portfolio to receive the designation in the past six months. In December 2020, sotorasib, which is being assessed in non-small cell lung cancer, won Breakthrough Therapy Designation. In February the drug was granted Priority Review by the FDA for patients with KRAS G12C-mutated locally advanced or metastatic NSCLC, after receiving at least one previous systemic therapy.
BioSpace source:
https://www.biospace.com/article/amgen-s-gastric-oncology-drug-gained-in-five-prime-acquisition-granted-breakthrough-therapy-designation
April 20, 2021 /by Andrew Humphreys
https://www.pharmalive.com/wp-content/uploads/2021/02/Amgen's-Sales-Team-Faces-Layoffs-Hundreds-of-Jobs-Cut-at-Headquarters-BioSpae-2-4-21.jpeg 350 625 Andrew Humphreys https://www.pharmalive.com/wp-content/uploads/2020/01/Pharmalive_4c-300x37.png Andrew Humphreys2021-04-20 12:16:322021-04-20 13:01:03Amgen Awarded Breakthrough Therapy Designation
EU regulator backs J&J shot, finds possible link to clots Humanigen's Cytokine Storm Control Drug Shows Positive Results


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The Beginner's Guide to Pre and Post Workout Supplements
Health	by Amanda Woerner on 9/2/2014
By now you've probably found your go-to protein shake recipe, and you may even carry a shaker bottle to the gym. But when it comes to maximizing your workout performance and recovery, is protein powder all you need?
For athletes striving to achieve a new strength goal, boost their exercise intensity, or take their endurance to the next level, a workout supplement may help. "The thing I tell people is that supplement use is the last two to three percent of performance," says Jason Machowsky, Board Certified Sports Dietitian and Performance Specialist at the Hospital for Special Surgery in New York City.
The big three? Protein powder (see our handy guide here), pre-workout supplements and post-workout supplements.
For your pre-sweat prep, you'll want to search for a product containing carbohydrates and moderate amounts of caffeine — to delay fatigue and help you stay strong through that final set of intervals, or that last mile of your long run.
Then, immediately following your training session, a post-workout recovery blend is one way to potentially speed muscle recovery. Got tired legs? Experts point to tart cherry and branched-chain amino acids as two common post-workout ingredients that may help prevent soreness and repair taxed muscle tissue.
Get the run-down on six fundamental ingredients you can expect to find in a pre- or post-workout supplement:
1. Carbohydrates
Pre or Post: Both
It may seem obvious, but carbohydrates are key to any athlete's prep routine, especially if you're exercising for more than an hour at a time. "Carbs refuel your muscles, and get stored as glycogen. When glycogen is depleted, that's what's associated with fatigue and hitting the wall," says Nancy Clark, RD, author of Nancy Clark's Sports Nutrition Guidebook.
That said, a big plate of pasta isn't exactly a recipe for success — especially right before a workout. Instead, fueling with a supplement or sports drink can be a great way to ensure your body's gas tank stays is full. "[Carbs are] the quickest and easiest way for your muscles to get energy," Machowsky says. "Especially when you're working at higher intensities, your body will use a greater percentage of carbohydrates for fuel."
Once you've powered through the final moments of your sweat session, carbs are still crucial. "If you knock the glycogen stores down to where you are highly fatigable and grumpy, what did you gain?" says Dave Ellis, RD, CSCS, past-president of the Collegiate and Professional Dietitians Association "And, if you don't replenish, it puts you at greater risk for injury."
How much: Each day, people engaged in a heavy, high-intensity training routine should aim to consume 3.2 to 4.5 grams of carbohydrates per pound of bodyweight that they carry, according to the Academy of Nutrition and Dietetics. To determine how to break down your pre- and post-workout carb intake, consult a sports nutritionist as recommendations will vary depending on your individual training routine and goals.
2. Caffeine
Pre or Post: Pre
When consumed pre-workout, caffeine can be key to making a long session feel more effortless, Clark says. According to the American College of Sports Medicine, recent research indicates that athletes who consumed moderate amounts of caffeine one hour prior to a workout increased their endurance during spinning and running tests (in a laboratory setting).
Just be sure to double-check the caffeine dosage on your supplement label. "If you take too much you can feel jittery, nervous, nauseous," Clark says. "People learn through trial and error the right amount of caffeine to take. Some people who are caffeine sensitive may want to avoid things [with caffeine] because it makes them feel not so good."
How Much: To figure out your limits, consider this: A tall 12-oz cup of Pike Place coffee from Starbucks contains about 260 milligrams of caffeine. According to the FDA, the average American consumes about 200 mg of coffee per day and, as a rule, people should never consume more than 600 mg each day.
3. Vitamin C
Most commonly known as the supplement people reach for when they feel a common cold coming on, vitamin C plays an essential role in helping the body deal with stress, whether from environmental factors or a strenuous workout schedule, according to Machowsky.
"Vitamin C is an antioxidant, which helps with dealing with metabolic stress — and training is metabolic stress," Machowsky says. "Anytime you're putting the body under a stress load, having things in the system to help deal with that stress load can be helpful."
Bonus: Vitamin C may also help reduce an athlete's likelihood of developing coughing or wheezing before and after exercise.
How Much: No more than 2,000 mg per day. Male adults should get at least 90 mg per day, while women should get 75 mg per day, according to the National Institutes of Health.
4. Vitamin B6 and B12
While clinical vitamin B12 deficiencies are relatively rare, it's not uncommon to be slightly deficient in B vitamin complex, particularly B6. Though more research is needed, it's possible these nutrients can be more easily depleted when the body is under stress.
RELATED: The Benefits of Vitamin B Complex
According to the National Institutes of Health, vitamin B helps the body form red blood cells and get or make energy from food. It can also help reduce inflammation and regulate mood and sleep patterns. In other words, this vitamin helps fine-tune the essential bodily processes that need to be in place in order for you to feel strong during a workout, or any other time of day.
How Much: Adults should get a minimum of 2.4 micrograms of B12 per day. For Vitamin B6, adults should aim to consume at least 1.3 miligrams per day, but no more than 100 mg.
5. Tart Cherry (Juice or Powder)
Pre or Post: Post
This stone fruit is quickly emerging as a favorite post-performance superfood for endurance athletes because it has similar effects to non-steroidal anti-inflammatories (NSAIDs).
"[Tart cherry] has an effect right away, like an Ibuprofen would, so you can use it for pain, you can use it for muscle damage, and it looks like you can use it as a potential chronic anti-inflammatory," says Dr. Kerry Kuehl, an associate professor at Oregon Health and Science University and co-director of OHSU's human performance laboratory.
A small 2010 study conducted by Kuehl and his colleagues revealed that marathoners recovered more quickly after knocking back a glass of tart cherry juice post-race. The juice drinkers recovered their strength more quickly and experienced less inflammation post 26.2 than those who drank a placebo beverage.
RELATED: 9 Homemade Sports Drink Recipes
"Tart cherry has phytochemicals that are very health protective," Clark says, noting that other dark fruits, like blueberries juice and grape juice, also have similar properties. Now, researchers throughout the country are working on developing tart-cherry derived supplements and medications. Expect to see a range of new products on the market that aim to harness the superfood's powers.
How Much: The jury's still out. Runners who consumed up to two 10-ounce bottles of tart cherry juice, or the equivalent of 45 tart cherries recovered faster post-marathon in Keuhl's study. Amounts of tart cherry powder in post-workout supplements will vary.
6. BCAA Blend
Branched chain amino acid (BCAA) blends consist of a mixture of three important amino acids: leucine, isoleucine and valine. The body uses amino acids to help digest food, repair body tissue and promote growth, among other functions. Commonly found in protein sources such as meat and eggs, the three amino acids that make up BCAA blend are essential for people looking to build muscle, and also repair damaged muscle tissue after intense workouts.
"The most important [essential amino acid] in the blend is leucine, especially when it comes to fixing the damaged muscle," Ellis says. "[It's particularly important] when we get done beating a muscle up with a lot of work in the weight room or sprinting or running steps, or pounding for an endurance athlete."
Also found in some protein powders, BCAAs "help perpetuate that strong signaling in the body to fix a damaged muscle," says Ellis.
How much: While dosages will vary depending on a person's goals, an athlete can consume up to 20 grams of BCAA per day.
Because the U.S. FDA does not regulate supplements, it can be tricky to know which blends work, and which are bogus. Always look for a brand that has been produced in an FDA-certified Good Manufacturing Practices (GMP) facility, or carries a label that identifies it as a USP Verified Dietary Supplement. This ensures you're getting a product that actually contains what it says it does.
In general, Machowsky advises clients to avoid "anything that doesn't have research behind it," and to be wary of supplements with long ingredient lists. Because new information is still being discovered about many ingredients found in supplements, its unclear how some these compounds interact with one another. In other words, it's best to keep supplementation simple. And always avoid supplements that include mega-doses of ingredients like caffeine.
Still confused? Don't hesitate to consult with a sports nutritionist to figure out the best mixture of ingredients for your individual needs.
Regardless of the supplement you choose, it's important to remember that they'll do little for you unless you already have a solid foundation of good health habits in place. Sleep, a nutritious diet and safe exercise habits are the most important ingredients for workout success.
"Trying to take supplements when the basics are shot is like putting lipstick on a pig," says Machowsky. "That being said, if someone is firing on all cylinders, there are a few supplements which have some good research showing they could be useful."
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Smarter Living|Why It's So Hard to Admit You're Wrong
Why It's So Hard to Admit You're Wrong
CreditCreditPaul Rogers
By Kristin Wong
Despite your best intentions and efforts, it is inevitable: At some point in your life, you will be wrong.
Mistakes can be hard to digest, so sometimes we double down rather than face them. Our confirmation bias kicks in, causing us to seek out evidence to prove what we already believe. The car you cut off has a small dent in its bumper, which obviously means that it is the other driver's fault.
Psychologists call this cognitive dissonance — the stress we experience when we hold two contradictory thoughts, beliefs, opinions or attitudes. For example, you might believe you are a kind and fair person, so when you rudely cut someone off, you experience dissonance. To cope with it, you deny your mistake and insist the other driver should have seen you, or you had the right of way even if you didn't.
"Cognitive dissonance is what we feel when the self-concept — I'm smart, I'm kind, I'm convinced this belief is true — is threatened by evidence that we did something that wasn't smart, that we did something that hurt another person, that the belief isn't true," said Carol Tavris, a co-author of the book "Mistakes Were Made (But Not by Me)."
She added that cognitive dissonance threatened our sense of self.
"To reduce dissonance, we have to modify the self-concept or accept the evidence," Ms. Tavris said. "Guess which route people prefer?"
Or maybe you cope by justifying your mistake. The psychologist Leon Festinger suggested the theory of cognitive dissonance in the 1950s when he studied a small religious group that believed a flying saucer would rescue its members from an apocalypse on Dec. 20, 1954. Publishing his findings in the book "When Prophecy Fails," he wrote that the group doubled down on its belief and said God had simply decided to spare the members, coping with their own cognitive dissonance by clinging to a justification.
"Dissonance is uncomfortable and we are motivated to reduce it," Ms. Tavris said.
When we apologize for being wrong, we have to accept this dissonance, and that is unpleasant. On the other hand, research has shown that it can feel good to stick to our guns. One study, published in the European Journal of Social Psychology, found that people who refused to apologize after a mistake had more self-esteem and felt more in control and powerful than those who did not refuse.
"In a way, apologies give power to their recipients," said Tyler Okimoto, an author of the study. "For example, apologizing to my wife admits my wrongdoing; but apologizing also gives her the power to choose whether she wants to alleviate my shame through forgiveness, or increase my shame by holding a grudge. Our research has found that people experience a short-term increase in their feelings of personal power and control after refusing to apologize."
Feeling powerful may be an attractive short-term benefit, but there are long-term consequences. Refusing to apologize could potentially jeopardize "the trust on which a relationship is based," Mr. Okimoto said, adding that it can extend conflict and encourage outrage or retaliation.
When you refuse to admit your mistakes, you are also less open to constructive criticism, experts said, which can help hone skills, rectify bad habits and improve yourself over all.
"We cling to old ways of doing things, even when new ways are better and healthier and smarter. We cling to self-defeating beliefs long past their shelf life," Ms. Tavris said. "And we make our partners, co-workers, parents and kids really, really mad at us."
Another study, from the Stanford researchers Carol Dweck and Karina Schumann, found that subjects were more likely to take responsibility for their mistakes when they believed they had the power to change their behavior. This is easier said than done, though, so how exactly do you change your behavior and learn to embrace your mistakes?
The first step is to recognize cognitive dissonance in action. Your mind will go to great lengths to preserve your sense of identity, so it helps to be aware of what that dissonance feels like. Typically, it manifests as confusion, stress, embarrassment or guilt. Those feelings do not necessarily mean you are in the wrong, but you can at least use them as reminders to explore the situation from an impartial perspective and objectively question whether you are at fault.
Similarly, learn to recognize your usual justifications and rationalizations. Think of a time you were wrong and knew it, but tried to justify it instead. Remember how it felt to rationalize your behavior and pinpoint that feeling as cognitive dissonance the next time it happens.
Mr. Okimoto said it also helped to remember that people were often more forgiving than you might think. Traits like honesty and humility make you more human and therefore more relatable. On the flip side, if it is undeniably clear that you are in the wrong, refusing to apologize reveals low self-confidence.
"If it is clear to everybody that you made a mistake," Mr. Okimoto said, "digging your heels in actually shows people your weakness of character rather than strength."


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Although modern medicine and technology have managed to make childbirth a relatively routine medical procedure, it remains fraught with potential complications. Most problems that do arise during labor can be relatively minor, but some situations can turn a delivery room into an emergency operating theater.
If your delivery was complicated by shoulder dystocia and your or your baby was seriously injured, it's important to get an experienced medical injury lawyer.
What Can Cause Shoulder Dystocia?
Fetal macrosomia – a larger-than-average fetus – can also contribute to shoulder dystocia. These are babies with a birth weight of more than 8 pounds, 13 ounces, which translates into about 9 percent of babies born across the globe. Symptoms that might suggest fetal macrosomia include large fundal height – the distance between the top of the uterus to the pubic bone – and too much amniotic fluid.
Finally, a protracted labor can increase the chances of shoulder dystocia.
Symphyseal separation or diathesis, with or without transient femoral neuropathy.
Erb's Palsy – This version of a brachial plexus palsy injury affects the upper nerves of the arm, the upper C5–C6 nerves, in particular, leaving the limb paralyzed, either partially or fully.
Klumpke's Palsy – This brachial nerve injury damages the lower C8 and T1 nerves. This includes the wrist and fingers.
Clavicle fracture – This is a break in the bone connecting the breastbone to the shoulder.
Fetal hypoxia – When the fetus is deprived of oxygen for too long, it can suffer fetal hypoxia sand can lead to temporary or permanent neurologic damage.
Humerus fracture – This is a break in the upper arm.
If your labor included complications that resulted in these of forceps to facilitate delivery, and your baby has been injured as a result, get in touch with the Colorado medical malpractice lawyers at Burg Simpson Colorado immediately by calling 303-792-5595 or fill out our Free Case Evaluation Form now so we can speak with you.


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Q: Problem creating ActiveRecord model: data missing from save I'm having trouble creating a new model row in the database using ActiveRecord in a Sinatra app I'm developing. The object in question is being created without any errors (using save!, no exceptions are raised), but most of the data I specify for the save is not present.
class ProjectMeta < ActiveRecord::Base
    attr_accessor :completion_ratio, :num_stories, :num_completed_stories, :original_target_date, :current_target_date

    ...

    def self.create_from_project(project)
        meta = ProjectMeta.new
        meta.project_id = project.id
        meta.num_stories = project.num_stories
        meta.num_completed_stories = project.num_completed_stories
        meta.completion_ratio = ProjectMeta.calculate_ratio(project.num_completed_stories, project.num_stories)
        meta.current_target_date = project.current_target_date
        meta.save!
        meta
    end

    ...

end

All inspections on the data from the project object I'm sending as well as the new meta object I'm creating show that the data is present. But when I do a meta.inspect before and after the save, it shows that all the data (aside from project_id) is in it's default state (zeroes). I've also checked meta.errors.nil? and sure enough, there aren't any errors after the save.
What is most puzzling is that if I turn around and get a new meta instance with that project_id and put the data in, it saves no problem to the db.
This is frustrating me because I've built several sites in Rails and Sinatra with ActiveRecord. This one issue is completely perplexing me. Can anyone tell me what I'm doing wrong?

A: Here is how it works

*

*On first access to model, columns from corresponding database table are retrieved and stored inside model data. This information can be retrieved through ::columns class method.

*When you access some model's attribute, Ruby doesn't find corresponding method in class and launches #method_missing method. That method inspects model's ::columns to check if corresponding column exists. If so, it creates an accessors for that column so that next time you access that model's attribute, an accessor method will be called directly, without need to call #method_missing (the later is slower).
The accessors look like this:
def my_attribute
  read_attribute(:my_attribute)
end

def my_attribute=(value)
  write_attribute(:my_attribute, value)
end

For #read_attribute and #write_attribute methods there is a shortcut: #[] and #[]=. If for some reason you will need to access underlying data directly (e.g. do some data conversion), you can write them short:
def my_attribute
  self[:my_attribute]
end

def my_attribute=(value)
  self[:my_attribute] = value
end

Model has a special accessor -- #attributes -- which returns a "column_name => value" Hash.
NOTE: the data for each column is stored in a special Hash instance inside your model instance, not in "@column_name" instance variables. When you define accessors with #attr_accessor, you block the usual way of defining attribute accessors via #method_missing. Your data is stored in instance variables instead of "attributes" hash, so it is not saved into database.
If you want to add new attribute to your model, you actually need to add column to database table that correspond to that model and then reload the whole application.

A: There's an important distinction between database fields and temporary attr_accessor declared properties. If you've declared your columns, then attr_accessor declarations are unnecessary.
Keep in mind that the data should be stored in the model's attributes property to be properly saved, not as individual instance variables.
For example, to see what's scheduled to be saved:
class MyModel < ActiveRecord::Base
  attr_accessor :not_saved
end

model = MyModel.new(:not_saved => 'foo')

puts model.attributes.inspect

There are methods to get information on what columns are available in a model, such as:
MyModel.columns_names

A: The attr_accessors will never be saved to the DB.  These are internal variables within the instance.  If you want to save the values, you have to create real columns.
Make a migration to declare the columns then try again.

redpajama_set_name: RedPajamaStackExchange


text:
Discover the Life
UninstallService 2023 is available to upgrade for all UninstallService.com users
December 8, 2022 December 8, 2022 by Avampatodiscoverymuseum.org Editor
UninstallService is an impressive and one of the most cost-effective app removal solution for desktop Windows and Mac computers. It is lightweight yet powerful to get the removal job done without any hassle. The new upgraded UninstallService 2023 offers removal capability for more than 10,000 new apps, including some of these apps below.
Quicker is an efficiency tool for the Windows platform, developed by an independent developer, whose logic is similar to that of the software launcher, but with more in-depth functionality based on shortcuts. The highlight of Quicker is that you can write your own actions through visual programming, and the official shared library is full of interesting actions, making it a shortcut command for Windows. Quicker has been developed at a rapid pace, and its features have evolved to become stable. Now that Quicker is in its official 1.0 release, we'd like to take this opportunity to introduce Quicker in detail.
When faced with a new efficiency tool, many people may be confused about what Quicker can do. So what can Quicker do? The "Batch Dissolve Folders" shown here would have taken a lot of time and effort to do, but with Quicker you can do it in one click. These shortcuts are the beauty of Quicker, the Swiss Army knife for Windows users. Everyone can reduce the complexity and repetition of work with pre-defined actions. It's easy to achieve the desired effect even if you don't have any coding skills.
The main body of Quicker is designed to be very simple, with many functions and windows hidden behind the software. Let's start with the simplest ones, starting with the main panel and the trigger method.
Quicker's main panel
The main panel is divided into two parts: the global panel area and the contextual panel area.
Global panel area: This is the upper 3×4 area where the global action panel will be displayed in any case.
Contextual panel area: This is the 4×4 area in the lower half of the window. The global actions panel changes automatically depending on the current window. For example, if I trigger Quicker in Chrome, then the General Actions panel will show the Chrome-related actions.
With such a design, it is possible to use both global and contextual actions. The global panel can be used to open software and switch panels. The contextual panel can be customized for a particular software.
The number of cells in both areas is fixed, and each cell of the panel can hold one action. If the 12/16 grid doesn't fit, you can tap the ☰ button on the left side of the middle waist bar to enter the panel management interface and click Add Panel to add a panel, which is somewhat similar to adding a screen to your phone's home screen. The added screen can be switched between pages by mouse wheel. Many improvements have been made to the panel management features in version 1.0. Folders in earlier versions have become multiple panels without secondary directories (if upgrading from version 0.11.* or earlier, you will need to process the upgrade). You can reorder, modify actions, attach generic actions, etc. for panels in the admin page.
Downie is an old and powerful video downloader that supports over 1000 streaming sites, including YouTube, Vimeo, Bilibili and Youku, both at home and abroad, and is sure to meet your needs. Simply copy the link to the web page where you want to download the video into Downie, and Downie will automatically parse the video from the link and start downloading it. Of course, you can also drag and drop the URL link of a video page directly into Downie to quickly create a download job. If you have multiple videos to download, just press Command + O and paste in the links to the videos you want to download and you're ready to download them in batches. The most intuitive way to use Downie to download videos from the web is through the browser plugin, just click on the Downie browser plugin icon on the video page and you can create a video download task with one click.
Of course, you may want to download a movie on a whim, and you can use Downie's search function to search for videos related to that movie to download. If you don't know what to watch, you can also check Downie's download charts here, and you may find a video you want to watch. Although it is a professional video downloader, Downie can do much more than that. By parsing the files contained in the links, it can also help you download files in DMG, ZIP, RAR and other formats from the web. It can be used to solve some occasional needs. In addition to just downloading videos, Downie also lets you customize the download options for your videos. If you need to download videos in MP4 format for use in iTunes, or just need background sound for your videos, Downie's post-processing capabilities can help you do that.
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Sundays up to Oct 28..
I'm excited to attend this kind of event! I can stock up healthy and nutritious goods and meet different kinds of people. I just hope I can attend this year. I'm excited to see good food and meet good people. I wasn't able to go last year because of my schedule at work. Now that I manage a small store down town, I can go to places whenever I want. I'll be sure to visit your page from time to time so that I will be updated.


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Joint Position Statement by HAI, The Commons Network and Public Citizen.
Both the European Union (EU) and the United States (US) are confronted with increasingly high medicine prices. European Member States are facing a looming access to medicines crisis as they struggle to afford new, patented, high-priced medicines. The Transatlantic Trade and Investment Partnership Agreement (TTIP), now under negotiation, could hamper needed changes towards affordability, needs-driven innovation and alternative incentive structures.


text:
B&N Reports eBook Revenues Down 15%, But Not Due to "The Hunger Games"
20 August, 2013 7 May, 2017 Barnes & Noble15 Comments
Barnes & Noble released their quarterly report for Q1 2014 today, and the news could not be worse.
Revenues are down significantly, with both B&N's retail division and Nook division reporting 10% and 20% drops in revenue.
But hey, B&N is still going ahead with their plans to release a new gadget later this year. (It might even be a color device, if the footnote is to be believed).
This spreadsheet sums up the bad news:
Retail sales were down both in store and online, thus giving us a lesson in why you shouldn't tell your customers that you plan to close 20 stores a year for the next decade. It tends to destroy consumer confidence.
The Retail segment, which consists of the Barnes & Noble bookstores and BN.com businesses, had revenues of $1.0 billion for the quarter, a decrease of 9.9% from the prior year. The sales decrease was attributable to a comparable store sales decrease of 9.1% for the quarter, store closures and lower online sales, in line with company expectations. First quarter comparable bookstore sales decreased, reflecting lower NOOK device unit volume and a title lineup last year that included unusually strong sales from The Hunger Games and Fifty Shades of Grey trilogies. "Core" comparable bookstore sales, which exclude sales of NOOK products, decreased 7.2% for the quarter. Excluding the impact of the two mentioned trilogies, Core comparable bookstore sales decreased 2.9%.
The B&N College division reported revenues were up about 2.4%, but in comparison to B&N's overall revenues that 2.4% raised "hardly anything" in terms of revenue to "still not much":
The College segment had revenues of $226 million during a period that did not include a back-to-school rush season, increasing 2.4% compared to a year ago, as a result of new store growth. Comparable College store sales decreased 1.2% for the quarter, reflecting the retail selling price of new or used textbooks when rented, rather than solely the rental fees received and amortized over the rental period.
And then there's the news from B&N's digital division, which is so bad that it even surprised me. Digital revenues and hardware sales were both down from last year because fewer people are buying tablets, ereaders, and content from B&N.
The NOOK segment, which consists of the company's digital business (including devices, digital content and accessories), reported revenues of $153 million for the quarter, a decrease of 20.2% from a year ago. Device and accessories sales were $84 million for the quarter, a decrease of 23.1% from a year ago, due to lower unit selling volume. Digital content sales were $69 million for the quarter, a decline of 15.8% compared to a year ago, due in part to lower device unit sales as well as the comparison to The Hunger Games and Fifty Shades of Grey trilogies. Excluding the impact of these two titles, digital content sales decreased 6.9%.
I would ignore what B&N is saying about Hunger Games. That movie came out in March 2012 (and left most theaters by mid-April), while this financial report covers May, June, and July. I doubt the spike in book sales generated by the movie last year affected B&N's revenues in the May-July period of 2012.
I wish we could write off some of B&N's drop in revenue as being caused by that movie creating a spike in book sales revenue in 2012, but it's just not plausible. No, B&N's problems are mostly the fault of B&N. They've mismanaged their Nook investment, destroyed consumer confidence, and generally mucked things up.
On a related note, I think we now know why Bill Lynch left. I've been told that I was wrong to describe that event as a firing (given the suddenness) but that doesn't change the possibility that he left in early July because of the previous couple months sales reports.
On the plus side, with Lynch out maybe B&N Chairman Riggio will be able to rescue B&N. Speaking of which, the press release also mentions that Riggio has canceled his plans to buy the retail division from B&N. I guess with retail revenues down there was little point in splitting up the company.
B&N and S&S Kiss and Make Up After Months Long Fight
The "Spotify for eBooks" Has Arrived – Nuvem de Livros
Barnes & Noble's Nook Service Still Crippled by Hack
Barnes & Noble is Now Informing Customers About Data Stolen During Saturday's Hack
All of Barnes & Noble's Computer Systems Are Down, and I do Mean All of Them
wayne leong20 August, 2013
They lost me as a frequent customer, when they closed their store in my normal driving area , and moved the store to an area much farther away, where I hardly drive to . And to make up for this, I just go to the competition bookstore that was a couple stores away from the closed store.
Michelle Louring20 August, 2013
I wanted to order a Nook the other day… Until I realized that it doesn't ship to anywhere but the US or UK and even if it did, I wouldn't be able to access the Nook store from where I am.
Guess I'll just have to order a Kindle, 'cause guess what? Amazon knows how to ship things across borders.
I wonder what their secret is…
flyingtoastr20 August, 2013
Don't complain abut BN, complain about international trademark and copyright laws.
Brian20 August, 2013
No, complain about B&N. They've had years to go international, just like all their competitors.
yuzutea20 August, 2013
Other e-ink readers are available overseas. It is not legally impossible.
Alexander Inglis20 August, 2013
On the investment call, they stated they closed 9 college stores and opened 15 more; closed 2 retail stores and opened one more (Indianapolis, 28,000 sq ft!).
Since inception, they have sold 10M Nook devices: some households have multiple Nooks (you know who you are), and 6M accounts running Nooks apps only. Of the "active" accounts with a Nook, they buy 3 to 4 books a month. They would not say how many are "active", "low usage", "lapsed"; and they admitted they do not even have this data for app only customers.
They essentially said Lynch left the company because of the device inventory issues: far more devices were acquired than they could sell which has led to continuing attempts to move existing stock at lower and lower prices (GlowLight now $99, regular price). One new device is coming this fall; they did not comment on a partner for a colour tablet.
There are no plans for further international expansion at this time (sorry, Canada). It's expansion of Nook Books only is limited to obligations under its Microsoft deal which includes 10 countries only via Windows 8 platform.
There is no active program underway to split the company; in fact, they are focussed on consolidating it again "for the benefit of customers". They said Nook losses ($55M this quarter) would be made up though Nook division, not using Retail profits (reminder: the Nook division includes the College stores but not BN.com website).
It's hard to fathom how they are selling less unit volume, less revenue in the e-book business, but there it is. At one point they mentioned a 22% marketshare which is significantly down from previous estimates of 28%.
This was another big ouch quarter and a lousy start to the fiscal year.
fjtorres20 August, 2013
The reason for lower digital content sales are three-fold:
– new reader syndrome: the first thing most people do when they get their first reader is to go on a shopping spree to load up on ebooks and stockpile a deep TBR list. Which is why device sales peak in nov-dec but ebook sales peak in early jan.
– ADEPT support: Nooks not only support B&N ebooks but also generic ADEPT ebooks, which leaves their installed base vulnerable to poaching by Kobo, Sony, and the generic ebookstores. With the price fix ending, discounting is returning and shopping around can pay off.
– The war with S&S: B&N has been stocking less S&S titles for the bulk of the year. If you don't carry the books, customers can and do go elsewhere. In this case, Kobo, Sony, etc…
Death spirals are built off things like this.
cookie20 August, 2013
Someone please put B&N out of its misery.
willem20 August, 2013
Some years ago Geoff Gannon wrote a thoughtful article of why he was no longer interested in the company's stock. It has proved very prescient. Some quotes:
"Barnes & Noble's financial health would be fine without the Nook."
"The Nook isn't offsetting some problem. The Nook is the problem."
"Barnes & Noble has decided to develop the device themselves. That was stupid. And it still is stupid. And eventually it may prove suicidal."
"Right now, they're intent on death by Nook."
http://seekingalpha.com/article/258761-barnes-noble-hobbled-by-the-human-element
Glad I'm not a B&N shareholder.
I should clarify it is 10M households with Nook devices, not 10M Nooks sold. Because some accounts have multiple Nooks attached, there are more devices than accounts. They did say these 10M households include lapsed users and occasional users but declined to say what portion of the 10M were "active" accounts.
The number of accounts is basically the number of activated Nooks.
Which is…low…for an operation claiming 22% of the market.
I think B&N needs to be thankful Amazon doesn't disclose the number of units they sell.
(The recent Morgan Stanley estimate of Kindle sales puts their gadget sales at 20-30m *a year*.)
I suspect that many accounts have more than one device attached so the number of Nooks activated will be considerably more than 10M. And B&N says a further 6M accounts do NOT have a Nook attached. So, that's a base of 16M accounts. I am guessing there are a lot of households where there is more than one Nook sharing one account. Perhaps, then 15 to 20M Nook devices have been built and sold.
CEO Michael Quesby confirmed to Bloomberg this afternoon that the next Nook device will be a colour e-reader (Quesby specifically noted their tablets are for people who read). So I guess a form of HD e-ink is out of the question for 2013 as the company continues to work through inventory overhang from 2012. It also suggests B&N will not be aggressively pursuing audio and video services on its Nook tablets. It really leaves the Kindle Fire as the sole platform for a dedicated ebook, video tablet vs. a more all purpose iPad or Android tablet. Quesby also defended its tablet team and backpeddled on the idea it would stop making its own devices: it would continue to have partners but would be designing and selling them under Nook brand, not white label another device.
Todd P.20 August, 2013
Isn't the reference to The Hunger Games a reference to the prior year book sales, not the movie adaptation? Meaning sales of The Hunger Games and 50 Shades trilogies last year skews the current year comparisons? Especially for The Hunger Games, a movie last spring would likely drive book sales at the same time.
Nate Hoffelder20 August, 2013
The launch of the movie last year caused a spike in book sales.
Let me go back and make it more clear.


text:
Motorola's iPhone X clone is coming to the United States for $399
Corbin Davenport
2018/11/04 12:35pm PDT Nov 4, 2018
Last month, Motorola announced two new Android One devices for international markets — the Moto One and One Power. Both phones look remarkably like the iPhone X, and both have three years of promised security updates. It seemed unlikely that either phone would ever be officially sold in the United States, but Motorola has announced that the regular Moto One will be available from Best Buy on November 9th.
The model coming to the US is equipped with a Snapdragon 625 processor, a 5.9-inch 720 x 1520 LCD screen, 4GB RAM, a 3,000mAh battery, and 64GB of expandable storage. Unfortunately, it still ships with Android 8.0 Oreo, but updates to Pie and Android Q are planned. To make matters worse, the Moto One only works on GSM networks, even though most of the company's other devices are compatible with both GSM and CDMA carriers (even the sub-$100 Moto E5).
The Moto One will cost $399 in the US, which doesn't seem like a great price. For $50 less, you could get a Nokia 7.1, which has a better processor and higher-resolution screen. If you really want to buy one, the Moto One will be sold exclusively from Best Buy, and pre-orders are already live. Select retail locations will have them on November 11th.
Nest Thermostat E over half off ($79) at some Walmart locations, plus a free Google Home Mini
Samsung finally teases folding phone after years of rumors [Update: Possible display specs]


text:
Nkolmeyang peut désigner :
 Nkolmeyang, un village du Cameroun dans la commune de Lobo
 Nkolmeyang, un village du Cameroun dans la commune de Ngomedzap.

redpajama_set_name: RedPajamaWikipedia


text:
Minister O'Regan Launches $750-Million Fund for Oil and Gas Companies to Reduce Methane Emissions
From: Natural Resources Canada
The Honourable Seamus O'Regan, Minister of Natural Resources, today launched the $750-million Emissions Reduction Fund to reduce methane and GHG emissions. This fund provides primarily repayable funding to eligible onshore and offshore oil and gas firms to support their investments to reduce GHG emissions by adopting greener technologies and help maintain jobs in a time of economic hardship and uncertainty.
October 29, 2020 Ottawa, Ontario Natural Resources Canada
Canada is committed to achieving net zero by 2050 and exceeding our Paris Agreement targets by 2030. Methane is one of the most potent greenhouse gas (GHG) emissions, accounting for 43 percent of all GHGs in the oil and gas sector, which is why reducing methane emissions is a significant part of our climate plan. Taking action now to reduce these emissions will help Canada achieve its goal to protect the environment while growing the economy as we recover from the COVID-19 pandemic.
Announced by Prime Minister Justin Trudeau in April 2020, the fund provides up to $675 million to eligible onshore oil and gas companies to invest in green technologies to reduce methane emissions. The remaining $75 million is available to offshore oil and gas companies for capital investments and research, development and demonstration (RD&D) to reduce GHGs from offshore production in Newfoundland and Labrador.
Effective immediately, eligible onshore oil and gas companies can apply to the onshore stream via the Emissions Reduction Fund website. Additional details on the offshore streams can also be found online. Beginning November 9, offshore oil and gas companies will be able to apply for the offshore deployment portion of the fund.
This investment will greatly benefit the environment, the oil and gas industry, and workers and communities. It will help position the sector as a leader in building a low-carbon future and a key player in the growing global clean technology market. It will also ensure Canadian oil and gas companies remain globally competitive as the world continues to move toward a clean energy future.
"We're taking action to reduce greenhouse gas emissions in partnership with Canada's oil and gas sector. This will maintain good jobs and make sure our companies remain globally competitive for years to come."
Seamus O'Regan
Canada's Minister of Natural Resources
The $750-million Emissions Reduction Fund provides financial support for onshore and offshore companies to help them adopt greener technologies and maintain jobs in the oil and gas sector to help withstand the impacts of COVID-19.
The $675-million onshore stream will:
help firms deploy green solutions that will reduce their immediate costs while lowering emissions; and
support firms in their transition to a low-carbon economy allowing them to attract investments and raise their global competitiveness.
The $75-million offshore stream has two components:
The Offshore Deployment Program is a $42-million investment supporting capital projects designed to either reduce offshore GHGs or improve the environmental performance of offshore oil spill monitoring, detection and response activities.
The Offshore RD&D Program is a $33-million investment supporting environmental research, development and demonstration projects that advance solutions to decarbonize Newfoundland and Labrador's offshore industry. It is being delivered in collaboration with Petroleum Research Newfoundland and Labrador.
Prime Minister announces new support to protect Canadian jobs
New Oil and Gas Sector Emissions Reduction Fund Helps Economy and Environment
NRCan.media_relations-media_relations.RNCan@canada.ca
Office of the Minister of Natural Resources
ian.cameron@canada.ca
Follow us on Twitter: @NRCan (http://twitter.com/nrcan)
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When an 18-year old Kelly Clark won the snowboarding gold medal at the 2002 Olympics Games in Salt Lake City, the action sports world was literally at her feet. And while the next few years brought continued success, Clark struggled with insecurity, loneliness and depression. She was empty inside and didn't know how to fill the void in her heart.
But everything changed 10 years ago when she prayed to accept Jesus as her Savior. Now, the five-time Olympian, three-time Olympic medalist and five-time Winter X Games gold medalist has found true purpose in life and greater freedom in the half-pipe.
Chad Bonham: Tell me about your spiritual journey.
Kelly Clark: Snowboarding was everything that I knew. That's what I did and I poured everything I had into it. I thought that being successful and achieving my goals would go hand-in-hand with being happy. But by the time I was 18 years old, I had achieved everything that was in my heart to do and at the same time I wasn't finding the fulfillment I was expecting to get from it. All of the experiences were incredible and I wouldn't trade them for the world, but it wasn't fulfilling me. I went through the motions for a few more years, but I was looking for something more. When I was 20, I was contemplating quitting. I was at the first event of the season and I overhead a conversation between two girls. One told the other, "God still loves you," and that caught my attention. Later that day, I caught up with the girl and asked her what she meant. Before then, I'd never really thought about God. But there was an undeniable stirring in me and I couldn't ignore it. I thought being a Christian was about following rules and going to church and being good all the time, but this girl helped me understand that it's about having a relationship with God. That was where things shifted for me.
Bonham: After winning the gold in 2002, how did your newfound faith in God help you deal with the disappointment of finishing fourth at the 2006 Games?
Clark: By then, my identity had started to shift. Before that, my identity was in snowboarding. That's how people knew me and that's how I knew myself. That's where I got a lot of my self worth. That began to shift and I started to understand that I didn't get my worth from people or from the things that I did. It was from Christ. If I hadn't had that shift in my life, I think my world would have come crumbling down.
Bonham: Snowboarding is known as a youth-driven sport, so how have you been able to stay relevant for so long?
Clark: I competed against a 13-year old girl at the Winter X Games. I looked down at her birth date and it said 2000. I was like, "Huh, I wonder if she even knows what Y2K is?" But I guess I've just been able to build a foundation. The foundational skills of snowboarding are what pay off in the long run. That's something I've been able to build over time and that's benefited me a lot. With my age and looking at my career, perhaps I'm more comfortable in my own skin than I've ever been. I'm not trying to snowboard for other people anymore. That just kind of comes with age and growing up. That's helped me a lot. Some of that started right after the last Olympics (in Vancouver). I was having a conversation with one of my teammates and she asked me, "Aren't you so glad it's over? We don't have to compete anymore." I thought that was a strange comment but in that moment I realized that I was doing it for the right reasons. I wasn't looking at the Olympics to define me. I wasn't to arrive somewhere by performing well in a contest. So after those Games, I continued to compete that season and the year after that. I really had the goal of being intentional. I didn't want to do big tricks because it was an X Games final or an Olympics final. I wanted to call my own shots. I started to do that and I started to have more fun than I ever knew I could have.
Bonham: The last time we talked, you spoke of how you found a new sense of freedom in the sport when you first entered into a relationship with Christ. Is this recent success also an expression of that defining moment in your life?
Clark: I think so. It's definitely got to be a daily thing. There's no formula to walking with God. There's no formula to having success as an athlete. It's about relationships and it's a daily thing. You've got to revisit things and you've got to be willing to work on things all the time. You've got to fight for that connection with God all the time no matter what you're going through in life. I'm growing up. I'm maturing. But I definitely think that the backbone of this is the freedom and creativity I have without the fear of failing. If I fail, what's going to happen? Nothing. I'm not looking for my self-worth in the sport.
Bonham: What are some of the stabilizing forces that help you to maintain that desire to stay in a relationship with Christ?
Clark: People ask a lot about how I can be a believer in a culture that perhaps is counter cultural to what you believe in. I've come to the conclusion that I'm able to be in this culture and in this industry and fruitful because I don't look to my circumstances to determine what I believe to be true about God. I don't look to my situation to determine what choices I make. I've developed a good sense of values and beliefs. That's my reality. No matter where I am, God is still good. No matter where I am, nothing is impossible. It's those sort of principles that really anchor me. Over this past four years, I think I've done a pretty good job of not compartmentalizing my life. I take my core values and I live them out at home like I would in my snowboarding like I would at church with my friends. I'm willing to explore what that's supposed to look like. I want to be intentional. I want it to show up in my life every day. I really try to live out my values and be consistent. Another things that has helped has been staying connected to a community of believers. It's important to be around others that share your beliefs and share your values and people that can encourage you. We're not meant to do it on our own. We're meant to do life with God and with each other. I've been fortunate to have friends that are willing to invest in me even on the days when I'm not able to invest back into them. I'm thankful for people that have that selfless attitude and have helped me become a successful person and a successful athlete.
Bonham: Has having a platform within the snowboarding culture been a burden, a blessing or, at different times, both of those things?
Clark: I've always lived a life where what you see if what you get. I've never wanted to live two different lifestyles. The initial transition for me was perhaps the most difficult. It wasn't easy communicating what I believed and what my values were. Establishing that as a young adult was interesting. I was 20 years old when I got saved. But now I'm more comfortable with my beliefs and with who I am. I honestly don't think about it that much. I just try to live my life and I try to love people. I try to love God well and I try to love people well. Those are my main objectives.
Bonham: And that keeps it from becoming a burden.
Clark: Yeah, one of my approaches with my community, my friends, the companies I represent, has been to take the attitude of what I bring instead of what I can get. What can I give? Instead of thinking about building up my image or building up my brand or building up my career, I've turned it and taken the approach of focusing on what I can give instead of what I can get. It's been a very enjoyable process for me. That's more of a heart position that I've taken. It's been one of the greatest things I've ever done.
Bonham: Over the past 14 years, have you had opportunities to speak other athletes' lives like that one you talked about earlier spoke into your life?
Clark: I feel like there is great purpose in a lot of my endeavors. I've seen God in the middle of them. I've seen Him be faithful in those things. But I strongly believe in that saying, "People don't care what you know until they know that you care." That's been my goal and objective—to love people well. That's something I can bring to this community. As I've been open with my faith, there's a consistency that almost disarms people. They know what they're going to get when they see me. They know what they're going to get when they talk to me. If there ever is a need or if anyone's hurting, I'm the person they come to because they know what they're going to get. They know I'll pray for them. They know I'll encourage them. It's amazing that I get to be there for people. I'm sure I'll hear later on how God was working in it all, but for me, it's really about loving people well.
Fantastic witness. Please can I use a picture for a powerpoint presentation at church?
We don't own the rights to these photos but usually get them from teams and representative organizations for media use or from free usage sites such as Wikimedia Commons. That's what I would recommend you use for your church PPT.


The real estate lender expanded its senior housing lending and its relationship with one of the sector's largest owners with this $465 million deal.
Walker & Dunlop Inc. has signed on to acquire the loan origination and servicing platform of Johnson Capital.
Walker & Dunlop and an affiliate of a fund managed by Fortress Investment Group have entered into a JV to form a CMBS lending platform that will provide financing for multi-family and other CRE properties nationwide.


Villa Alina is a beautiful ancestral home built just off Calangute beach in North Goa. Boasting an impressive private infinity pool, six air-conditioned en-suite bedrooms, sumptuous soft furnishings and fine antiques. Villa Alina has become an exclusive holiday destination, which perfectly balances traditional Goan living with luxurious modern comforts.
Read more about Villa Alina here.
For Booking Enquiries please see our Availability calendar.
© 2019 Villa Alina All Rights Reserved.


2018 MS&E Reunion Recap: A Heartfelt and Engaging Event!
More than 150 MS&E alumni, faculty, and guests arrived on campus Saturday, October 27 to reconnect with old friends and make new ones during Reunion Homecoming weekend.
The MS&E program featured a special tribute in honor of Professor Ron Howard's contributions to the scientific community, most notably his work pioneering the field of decision analysis.
"Ron has created a school of thought in decision analysis—a very vibrant one," said MS&E Professor and Chair Nick Bambos in his opening remarks. "I know of very few people who can claim that they have created schools of thought," he said, and concluded by mentioning such schools created by Plato and Aristotle. "I think you can infer what I'm trying to say," he concluded, as the audience responded with knowing smiles and laughter.
Presentations inspired by Prof. Howard's impact were given by Ali Abbas (PhD '04), Professor of Industrial and Systems Engineering and Public Policy at USC; Jeannie Kahwajy (PhD '00), CEO of Effective Interactions; and Eric Horvitz (PhD '90), Director at Microsoft Research. The final lecture was given by Prof. Howard, who shared stories of his educational journey from childhood to his time at Stanford.
Ali E. Abbas' talk focused on the past, present, and future of the university. He stressed the importance of applicable knowledge, asking, "If we can't teach you skills that you can apply outside of the university, that can't be taught by experience, then what purpose does your degree hold?" He discussed the importance of simplicity in current decision analysis models and the likely possibility that in the future there will be a need for a larger variety of different iterations of decision analysis, but that the foundations will remain the same.
Jeannie Kahwajy spoke of the power of being perceptive and understanding people. She argued that although you can justify decisions by looking back at numbers, you have to talk to people to find out what really matters to them. "You have to know how to ask and how to listen," she said. Jeannie also discussed how a good idea must be proven worthy to garner attention but ideas need attention to be deemed worthy. This starts a vicious cycle and the best way to get out of it is to be ready to receive contributions from all sources and listen to the opinions of others. She concluded by saying that it is not enough to just come up with a better solution; it is also our job to bring more people into decision analysis.
Eric Horvitz's talk focused on the influence Prof. Howard's teachings had on him, as well as the intersection of artificial intelligence and decision analysis. He urged the audience to consider decision analysis as clear, systematic thinking about action; to pursue foundational principles of intelligence; to attend with sensitivity agency, values, and ethics; and to enhance lives and society. He said, "The influence diagram provides a new clarity to the conversation between decision-maker and analyst, allowing representations that are both easily understandable and mathematically consistent." And while pursuing advancement is important, you have to learn to stand for ethics over profits when building your career in decision analysis.
Professor Ron Howard's talk focused on the development of his lifelong education, the lessons he has learned from others throughout his career, and paying tribute to all those who have been a part of his professional journey. He spoke of the deep connection he formed with his mentor, Bill Linvill, who helped Prof. Howard become a part of the Stanford faculty in 1965. He emphasized several lessons that he learned from others throughout his career: a key part of understanding complex systems is creating simple and intuitively understandable models; you can't replace a good idea with a lot of capital; and some of the most important lessons you learn in life are taught serendipitously.
After the lectures, attendees enjoyed a networking brunch, visited the Stanford Bookstore table featuring publications by notable MS&E professors, and took fun photos at the social media photo-op.
View all lecture videos from the event.


I am a current PhD candidate in the Philosophy department of Columbia University, where I hold an M.A. and an M.Phil in Philosophy. My B.A. is from Williams College in both Philosophy and Classics. My primary interests are within philosophy of logic/mathematics and ancient philosophy, but I am also interested in the history of mathematics, philosophy of science, and American pragmatism (esp. Peirce).
I am also interested in Pedagogy training and development, both within Philosophy and more generally. I was previously a Lead Teaching Fellow within the Philosophy department, where I served as a point of contact between the department and the Columbia Center for Teaching and Learning, as well as a Teaching Scholar for the academic year 2016-2017. I am currently writing my dissertation, which has been funded by a Mellon/ACLS dissertation completion fellowship for the 2018-2019 academic year.