text:
NATPE 2018: Vinciquerra Wants More Scale for Sony
CEO says he'd like to have acquired the Fox assets Disney snagged
Kent Gibbons
Miami, Fla. -- Sony, like other media companies smaller than the likes of Facebook, Google and Amazon, needs to grow to survive or else become "somebody's purchase," Sony Pictures Entertainment chair and CEO Tony Vinciquerra said during a NATPE conversation with Soledad O'Brien Wednesday.
Vinciquerra, the former longtime Fox executive who signed on at Sony in May, said Sony would like to have bought the Fox TV and movie studio assets thatDisney is buying for $66 billion(including debt).
"The ironic part is I built most of the businesses that were sold so I knew them pretty well, and it would have been great to have them back," he said.
"We have to grow," he toldO'Brien. "If we don't grow, we will be somebody's purchase. But that's not our goal, our goal is to grow. I didn't take the job to do it for a year and sell the company."
He said he was drawn to theSonyjob partly because he thinks it's "the best positioned of any of the big media companies because of the parts of the business," ranging from consumer electronics to TV and movie production and channels around the world.
Still, with total market capitalization of about $60 billion, Sony is about one-tenth of the size of potential rival companies such as Google or Apple, he said.
Facebook, Google and Amazon see Sony and other content producers as sources of creativity to help the bigger companies meet their goals, which could mean selling more goods or making money from increasing searches, he said. But if the bigger outfits chose to, they could crush Sony. Therefore, "we have to have scale."
He said he had not discussed the possibility of combining with CBS with CBS chiefLeslie Moonves but otherwise did not spell out potential pathways to bigger scale. "I think you will see us do several new partnerships and mergers with other companies that we are partners in their business and new businesses," he said. He cited thenew partnership between Sony and Tegna local stationsthat was announced Tuesday at NATPE as an example.
When Disney-Fox and the contested (by the government)acquisition of Time Warner Inc. by AT&Tget resolved, that could open the floodgates to other big deals or, if either deal crashes, that could prompt media executives to get more creative about combinations to achieve the desire of greater scale, Vinciquerra said.
NATPE 2018: New Spanish Cinema Channel Launches
Atrescine to combine older, newer movies from Spain
Chairman and CEO, Fox Networks Group
Tony Vinciquerra, Soledad O'Brien to Headline NATPE Miami 2018
Facebook's Ricky Van Veen will keynote new streaming summit at annual programming conference
Tony Vinciquerra Named Chairman/CEO of Sony Pictures Entertainment
Former Fox Networks Group president/CEO succeeds Michael Lynton
NATPE 2018: Tegna, Sony Pictures Television Forge Partnership
SPT will distribute Tegna shows such as 'Daily Blast Live,' as well as sell national advertising, branded integrations
Tony Vinciquerra Leaves Fox
Well-respected veteran resigns; Fox shakes up Networks Group
Rasulo: Scale Not as Important as Impact
Disney CFO says consolidation not a priority
Fates and Fortunes
Anthony Vinciquerra Joins Machinima Board
Former Fox Networks Group CEO also a senior advisor for Texas Pacific Group


For a quick way to the end of the maze, hold down the Ctrl key and press theletters l e e (must be lower-case). This solution from acomp.sys.ibm.pc.games.adventure post by Peter Taylor of Sanctuary Woods. Agroan and a gurgle later, and you're at the end of the maze! But don't forgetthe items you need from inside the maze.
Touch urn in graveyard: "As long as the urn keeps burning, that's all Ineed"


text:
Munsell Color System; Color Matching from Munsell Color Company > Color Theory & History > Munsell Color Education Products: Fruits of Albert's Early Labors
Munsell Color Education Products: Fruits of Albert's Early Labors
Early work in color space theory
Albert H. Munsell had a passion and penchant for color and color communications early on in his career as an artist and later as a teacher. After graduating from the Massachusetts Normal Art School (today's Massachusetts College of Art and Design or "MassArt") in 1881, Munsell was hired by the institution as an instructor and later appointed lecturer in Color Composition and Artistic Anatomy. During his 25-year tenure with the school, Munsell applied his color theories to develop color education teaching tools such as the patented Color-Sphere and Mount—the predecessor to today's Munsell Color Tree. Munsell used the color sphere to organize color in a logical fashion for teaching purposes. Munsell says it in his own words in the 1900 Patent No. 640,792, "The object of my invention is to provide a spherical color-chart for educational purposes. It is necessary or desirable in the study of colors to the best advantage to be able to present a sequence of colors as they exist in nature and to present to the eye an orderly arrangement of colors in a great variety of sequences."
Munsell's early work in color theory, culminated in his book A Color Notation (1905) and two years later his Atlas of the Color Solid, which was the predecessor to today's Munsell Books of Color. Munsell didn't develop his groundbreaking work in a vacuum. Instead, he conferred with academics in the physical and psychological sciences, and later in his career was invited to present his color order work at conferences throughout Europe.
The consummate color educator and perpetual student of color, Albert H. Munsell's legacy lives on at the Rochester Institute of Technology's (RIT's) Munsell Color Science Laboratory. Today, the Munsell Color System can be taught or learned using a series of Munsell Color Education Products produced by the X-Rite Company. Perhaps Munsell said it best in his book, A Color Notation:
"The teacher's skill is shown in searching out the simplest and most easily grasped facts; in finding not only an 'easy door' but the 'right door'; in leading the children through the maze of color by steps so clearly understood and remembered that he will safely find his way along and not become confused."
He goes on to add:
"Let us concentrate public education upon a simple and definite training of the eye, so that it may be quick to recognize, define, imitate and memorize the colors in daily use."
The National Cyclopaedia of American Biography Volume XII, James T. White & Company, New York, 1904, pg. 316.
A Practical Description of The Munsell Color System with Suggestions for Its Use, T.M. Cleland, Munsell Color Company, 1937, Baltimore, Md.
A Color Notation, A. H. Munsell, Munsell Color Company, Inc., 1971, pg. 45.

redpajama_set_name: RedPajamaCommonCrawl


If you like it hot - this is the dip mix for you! We've blended chipotle peppers with the fiery habanero to create a deceptively hot snack. Be ready for fireworks at your next party!
INGREDIENTS: NO MSG, Minced onion, Tomato powder, Sugar, Salt, Chile peppers (chipotle pepper, crushed red pepper, habanero pepper), Bell peppers, Cumin, Oregano.


1/ Can I change my child's last name?
Many families argue over the child's last name, especially if one parent wishes to no longer be a part of the child's life. The Family Law Act 1975 does not state any specific rules on a child's name, however the courts can order for the child to be known under a certain name. The specific circumstances of each case will determine when and why a court might make such an order.
It is interesting to note that as the Registry of Births, Deaths and Marriages is not a party in the case, they are not bound to follow any set order from the Family Court.
2/ How do I divide my assets?
There is no set rule, and this is often an increasingly difficult process to attempt on your own. You'll also need to make sure that any property settlement is legally binding, which may not be the case if you try to do it yourself. A family lawyer will help you make a list of all of the current assets, liabilities and superannuation of each of the parties to arrive at a net figure, or what becomes known as the "net property pool". An assessment will be made of the contributions of each of the parties throughout the relationship, to the net property pool and to the welfare of the family. Any property settlement will also need to take into account the current and future circumstances of each of the parties.
3/ Should I inform the court on matters of family violence?
You should always tell the courts about matters of family violence and whether there are any domestic violence orders in place. This will help the court on many decisions; including custody arrangements, financial decisions and other major decisions that will impact the family unit.
In circumstances in which you do not inform the court, the court may make a decision that can reflect unfairly on you or lead to an unsafe environment for your children.
4/ Can a grandparent have a right to see the child?
Under Australian law, a grandparent does indeed have legal rights. If a grandparent wants to spend time with the child but have been denied by a parent, they may apply to the family court. However, it is recommended that the grandparents first seek mediation with the parents.
The courts will make a decision based on the best interests of the child. They will also look at other factors such as how much time have they spent together previously, how important the grandparents are in the life of the child and whether any disputes exist between the families.
5/ I am not spending any time with my child; do I still need to pay child support?
The simple answer is yes. If you are not present in your child's life, you are still expected to pay child support. A court will assist in deciding how much you must pay. If you feel that you are denied the right the see your child by the other parent, you can apply to the court for legally binding parenting orders.
6/ I want to apply for divorce, but I am not in Australia. Can I still do it?
No. Anyone applying for divorce in Australia must be an Australian citizen and have lived in Australia for at least 12 months.
7/ Is telling the school about the divorce a good idea?
It is important to notify the daycare, childcare provider or school about the family situation. You do not have to go into depth about the circumstances but just letting them know of any specific custody arrangements will allow for them to look out for the welfare of your child.
While these may be common family law questions, you may have others. Contact us today at Groom and Lavers for friendly, experienced advice.


text:
Q: How can i use BERT fo machine Translation? I got a big problem. For my bachelor thesis I have to make a machine tranlation model with BERT.
But I am not getting anywhere right now.
Do you know a documentation or something that can help me here?
I have read some papers in that direction but maybe there is a documentation or tutorial that can help me.
For my bachelor thesis I have to translate from a summary of a text into a title.
I hope someone can help me.

A: BERT is not a machine translation model, BERT is designed to provide a contextual sentence representation that should be useful for various NLP tasks. Although there exist ways how BERT can be incorporated into machine translation (https://openreview.net/forum?id=Hyl7ygStwB), it is not an easy problem and there are doubts if it really pays off.
From your question, it seems that you are not really machine translation, but automatic summarization. Similarly to machine translation, it can be approached using sequence-to-sequence models, but we do not call it translation in NLP.
For sequence-to-sequence modeling, there are different pre-trained models, such as BART or MASS. These should be much more useful than BERT.

Update in September 2022: There are multilingual BERT-like models, the most famous are multilingual BERT and XLM-RoBERTa. When fine-tuned carefully, they can be used as a universal encoder for machine translation and enable so-called zero-shot machine translation. The model is trained to translate from several source languages into English, but in the end, it can translate from all languages covered by the multilingual BERT-like models. The method is called SixT.

redpajama_set_name: RedPajamaStackExchange


text:
What's the future for Twitter CEO Jack Dorsey? | Opinion
As schoolboy, Sinn Fein's Eoin Ó Broin found himself following the…
Is the boom in communal living really the good life?
Feeling Betrayed, Far-Right Extremists Have A New Message For Trump: 'Get…
Three 'must-try' braai side dish recipes for the ultimate braai experience
Intellasia East Asia News – CES 2021 ELECLEAN Disinfectant Recognized by…
Vivekananda Statue — inspiration, not occupation
IBCC says SSC and HSSC exams to be held in May-June
Trump's Legacy: 2 Impeachments, An Insurrection, Countless Lies And Corruption
Naagin fame Mouni Roy getting married to Dubai based banker Suraj…
Karan Johar's Dharma Productions to reveal title and first look of…
'Old Faithful' galaxy has brilliant outbursts every 114 days
20 NHL Fantasy Thoughts: Devils' Jack Hughes making big strides early
Tariq Lamptey: Brighton defender signs new deal
Home Science Exclusive: 'Star Wars' scholar Phil Szostak on his stellar new concept art...
Exclusive: 'Star Wars' scholar Phil Szostak on his stellar new concept art book for 'The Mandalorian'
It's been just a little over three weeks since "The Mandalorian's" tearjerker Season 2 finale and we're already feeling the withdrawal with its weekly absence. Alas, this is the way!
To help with this temporary (we hope) absence of Mando, Grogu, Boba, Cara, Greef, Moff Gideon and the whole galaxy-hopping gang, a premium hardback was just released in December, written by Lucasfilm creative art manager Phil Szostak, titled "The Art of Star Wars: The Mandalorian" (Abrams, 2020).
This official 256-page, behind-the-scenes companion to the Disney+ series showcases a constellation of exclusive, first season concept art, character and costume sketches, alien world illustrations, weapons proposals, storyboards and designs for spaceships, vehicles and creatures.
Related: 'Star Wars'! 40 Surprising facts from a galaxy far, far away
It's an absorbing coffee table book dedicated to delivering an inside peek at the entire pre-production artistic process behind the smash-hit show. It also contains insightful new interviews with key cast, crew and creatives, including executive producer/showrunner/writer Jon Favreau and executive producer/director Dave Filoni.
Steeped in "Star Wars" lore, Szostak has been associated with its art departments since back in 2008. Besides being a key part of the narrative design team on LucasArts's "Star Wars: 1313" project, he also authored "The Art of Star Wars: The Rise of Skywalker" (Abrams, 2019) and "The Art of Star Wars: The Last Jedi "(Abrams, 2017).
Space.com connected with Szostak to hear what fans of "The Mandalorian" can anticipate in this lavish new art book, how the Disney+ series captures that classic "Star Wars" magic, and reveals his favorite pieces of concept art crafted for the production.
(Image credit: Lucasfilm)
Space.com: How does "The Mandalorian" present that old-fashioned "Star Wars" flavor and why do you believe fans respond so positively to it?
Phil Szostak: That's a very good question! It's often difficult, even for Lucasfilm employees and "Star Wars" scholars such as myself, to put your finger on what exactly the "Star Wars" aesthetic is, or what makes something feel like "Star Wars" versus something which doesn't quite hit the mark. And I think that has to do with how seemingly simple but actually complex what George Lucas did with "Star Wars" back in 1977. There are so many influences in the mix: Kurosawa samurai films, classic and Spaghetti Westerns, fantasy, Flash Gordon and Buck Rogers serials, New Wave cinema, Joseph Campbell's monomyth, etc.
In my opinion, what show creator Jon Favreau has done exceedingly well with "The Mandalorian," and why it resonates so strongly with the fans, is tell a simple and straight-forward, Western-inspired, Man-with-No-Name type story, with a very endearing and emotionally resonant story of found family and coming together at its core.
And that is exactly what the very best "Star Wars" stories have always done: tell simple stories with a strong moral and emotional center. But "The Mandalorian" does it both unencumbered by the preceding 40+ years of "Star Wars" storytelling and fully-immersed in the visual language and deep lore of that storytelling. And that side of things comes from having artists and filmmakers like Dave Filoni and Doug Chiang contributing decades of knowledge and expertise.
Space.com: In compiling images for this special concept art book, what surprises or fun facts did you learn about the making of the show?
Szostak: As a member of Doug Chiang's Lucasfilm art department, who worked on "The Mandalorian" since Day One, there honestly wasn't too much that surprised me in compiling the book.
But, as I started to interview everyone involved and put the sequence of events together, what really struck me is how an amazing series of coincidences brought Lucasfilm president Kathleen Kennedy, Jon Favreau, and Dave Filoni together, leading to the creation of the show: Favreau and Filoni having met and worked together on "The Clone Wars" a decade prior, Jon having played a Mandalorian on "The Clone Wars," Filoni subsequently learning the craft of live-action filmmaking on the set of the recent "Star Wars" films, and finally Kennedy being tasked with finding a filmmaker and show for Disney+.
Space.com: Doug Chiang and his Lucasfilm art team have conceived stunning art for the series that factors into the end title sequence of every episode. What makes their art so electrifying in capturing the essence of the franchise?
Szostak: The Lucasfilm art department truly is the A-Team each concept artist hand-picked by Doug to be a part of the project. Leading the charge is Chiang himself, who set the design language of the "Star Wars" prequels in motion with Episode I, with design supervisors and "Star Wars" prequel veterans Ryan Church and Erik Tiemens, ILM design veteran Christian Alzmann and concept model supervisor Rene Garcia.
They really are the best of the best, working on a project that they consider to be a career highlight. So the whole team, myself included, brings a lot of experience, passion and dedication to our work.
Space.com: Do you have any favorite artworks in the book and what emotions do they trigger?
Szostak: I was lucky enough to get my hands on and include a lot of Dave Filoni scratch paper sketches in the book. And one of my favorites is his very first sketch of Mando and the Child's initial encounter, the baby in his floating pram levitating a ball towards Mando. That moment really encapsulated what the whole show is about in one image, these two war orphans and lost souls connecting with each other.
"The Art of Star Wars: The Mandalorian" is available now from Abrams Books.
Today's best Disney+ deals
Follow us on Twitter @Spacedotcom and on Facebook.
Critical engine test for NASA's Space Launch System moon rocket shuts down earlier than planned


text:
What Does Valentine's Day Mean to You?
Elizabeth Heubeck
Tomorrow is Valentine's Day, a holiday that has very different implications depending on where you fall on the "significant other" spectrum.
Two of my female friends in their forties presently are not part of a pair. Both of these women regularly profess to wanting to find a love interest, badly. They share with me their sordid stories of blind dates, struggles with online dating services, utter frustration over the perceived lack of a strong pool of potential single male mates in this town.
Personally, I can't think of anything more torturous than trolling unknown places, virtual or real, for a mate. It's easy for me to say, they tell me dismissively; I've been married for almost half of my entire life. They, on the other hand, feel compelled to persist in their quest.
I marvel at their persistence, though at times it seems to border on the desperate, especially when one of these gals recently told me to be on the lookout for any of my friends who might be divorcing soon. Though I warned her that she probably wouldn't want to take on the baggage of a new boyfriend who was probably in an emotionally fragile state, plus his kids, she replied emphatically, "Well, I don't see it that way."
Okay, then. What she sees, I'm guessing, is the prospect of being swept off her feet by a man on a white horse, or a white sports car, and living happily ever after. And maybe this first part of the story does happen to most of us at one time or another, leaving us temporarily starry-eyed and giddy.
But after the wedding dress is stored in the attic and the ring starts to lose its glimmer, and unromantic factors like kids and mortgages and stressful jobs and aging parents enter the picture, the giddiness tends to subside.
Statistics support the notion that many long-term couples often lose their luster (or lust, as it were) for one another. Married couples report having sex an average of 68.5 times a year, which comes out to a little more than once weekly. Fifteen to 20 percent of couples have sex no more than 10 times a year, which puts these couples in the "sexless marriage" category, according to an article in Newsweek.
Home builders seem to be catching on to what appears to be more of a long-term trend than a mere blip on the marriage screen. The National Association of Homebuilders predicts that by 2015, 60 percent of new homes will be designed with "dual master bedrooms". This, in response to consumer demand. Sure, some of it has to do with multi-generational dwellings, in which aging parents come for long-term stays with their grown children. But I would venture to guess that's not the only reason for the dual master suites.
After all, one in four married Americans sleeps in separate rooms, according to an article on CNN.com. Nuisances like insomnia, bad backs, and snoring cause many couples to sleep apart. But why is it that these problems rarely seem to surface until a couple has been together for some time? In the throes of a new hot and steamy relationship, you rarely hear of couples having trouble sleeping together.
So, for those women "on the prowl" for a man this Valentine's Day, I caution them to think twice before plunging full-throttle into a long-term relationship. Judging by the statistics, maybe they'd be better off with a one-night stand.
sexless couples


Anglers are evolutionary creatures. When they first start fishing they just want to go fishing and catch some fish, generally any fish, but they want to catch some fish. If they persist at fishing they usually evolve to the next level; catching lots of fish. Then they generally move to wanting to catch big fish or even trophy fish. Somewhere along this evolutionary line they may become fly fishers, tournament anglers, or, horror of horrors, angling writers. Some people never evolve beyond wanting to catch a limit or getting just one more trophy for the wall, but many anglers find themselves seeking ways to put more challenge in their angling experience, and they begin to invent ways to make angling more exciting.
Years ago JC and I would play a game we called trout golf. It was a game that we played against ourselves, and the score was just a fun way to add a greater challenge to our times on the stream. Since most of our fishing in those days was dry fly fishing the rules of the game was basically quite simple. You counted each fish that rose to your fly, the number of fish that you missed when they rose, the number of fish hooked but lost, and finally the number of fish hooked and landed. Foul hooked fish did not count as fish hooked and landed. It wasn't serious, we never competed against each other, and it was all based on memory. It was just a fun activity.
In recent years I have changed the rules a bit by adding some handicaps. I fish a high mountain lake that has a good population of brown and rainbow trout. The lake has some excellent hatches during the summer season and I have limited myself to only fishing dry flies to visible trout. Some days I only cast to trout that I have seen rise to take a fly off the surface. Since the lake has a generous population of trout in various sizes on some days I decide that once I catch a 20 inch fish or an 18 inch fish I will quit fishing. Occasionally that means I only catch one fish, and some days I never have to quit until I get tired of casting.
Years ago I knew an angler that only fished with dry flies. To further add to his handicap he tied only one pattern and only two colors; light gray and dark gray. He tied them from size 8 to 28, but they were only in those two colors. His theory was that color was only a secondary consideration when choosing a pattern, and size and presentation were far more important to success. In the course of the season when trout were feeding on dry flies he was generally just as successful as all the other anglers, and in many cases he out fished the angler with a box full of more exacting patterns.
Today many states have specific regulations that specify that you must use barbless hooks, but JC and I were advocates of barbless hooks way back in the 60's. Many people thought that was a handicap, but we always believed that a barbless hook penetrated easier than a barbed hook, and was much easier to remove from the fish or from your own ear, if that became a necessity. I still fish with barbless hooks, but I never have considered it a handicap. I did know one guy that took the entire game one step further. He broke the barb completely off his flies so that a fish could never actually get hooked at all. He considered it a success if a fish rose and took his fly.


High Alch: 42 Coins; Low Alch: 28 Coins.
Used as food, it has 3 bites. Every bite heals 333 Life points, 999 Life points in total.
Made by using Chocolate dust with a Cake. Earns 30 Cooking exp.
This Data was submitted by: CrazedFred, Poison, Soviet Guard, Sharqua, Firkl�ver, Fudge, Im4eversmart, ossie000, Dipfur, Sam_B, marfnl, Hammeh, werepyre123, wildweed, Raniff, Star, and rbandboy.


Integrity School Portraits offers Photobooth Service for all types of parties and themes. As you can see below we have tons of Templates to choose from.
Valentines Day, Halloween Templates, Christmas and Holiday Celebration Templates, Cinco De Mayo Templates, Fourth of July Templates, St. Patricks Day Templates, Happy New Years Templates.
Summer Party Templates, Birthday Party Templates, Sweet 16, Quincanera, Mardi Gras Celebration Templates and Wedding Templates.
Father Daughter Dance Templates, Harvest Festival Templates, Winter Concert, Prom Templates, Senior Dance Templates, Graduation Templates.
We provide the props and the fun. Best keepsake gift for your party and for your guest!
Please choose which types of Print you would like for your event. One of the 3 Options: Strips, Post Card or Portraits Layout. Once chosen please fill out information and we will send you more information and quote for your next event to include Photography and Photobooth Service.


text:
Some New and Interesting Developments
For Patients (5)
MH and MHAUS Updates (17)
People Building Awareness (14)
Vlogs (1)
First, I would like to apologize for the somewhat technical blog I posted for October, 2010. I realize that not everyone would be familiar enough with the science of MH and cellular physiology to understand some of the information behind my reasoning. However, in basic terms what I was trying to do was separate MH into subcategories based on what is known of the molecular biology and biochemistry of the disorder. I realize too that not everyone would agree with my reasoning, but that is what a blog is for, i.e., theorizing and proposing some new ways of looking at things.
In this blog I would like to draw your attention to two new and interesting items related to MH. One of them is a promising test for MH susceptibility; the other is an aid for diagnosing and managing MH using the most modern technology.
The study I am referring is one that was done by investigators associated with the MH Investigative Unit at the Uniformed Services University in Bethesda. This group is virtually the only one in the US that studies MH from the clinical presentation to biopsy testing to molecular genetic testing in both animals and humans. The center is a tribute to the hard work and vision of Dr. Sheila Muldoon. Dr. Muldoon started her interest in MH when asked to develop the muscle biopsy contracture test for the military many years ago. Starting from that beginning she recruited many physicians and scientists to join her in developing a first class MH investigative unit that has contributed a great deal to the understanding of MH and the clinical care of MH patients and their families. She has also been a very valuable member of the Board of MHAUS for a long time. A recitation of the many contributions made by the group would take many pages. I will save that for another time perhaps.
The aforementioned study by investigators at the MH unit may lead to a test for MH susceptibility that bridges the gap between the muscle biopsy contracture test and the molecular genetic test. The former test is very accurate in detecting those who are MH susceptibles (no false negatives) at the expense of mislabeling a few patients as MH susceptible who may not be. The drawback of the test is that it is invasive, i.e., requires a muscle biopsy, specialized equipment and personnel, a surgeon and is very expensive. The other available test for MH is much less invasive. It only requires a blood sample for DNA analysis. The test is very specific; however it only detects about 30% of MH susceptibles with certainty. It is not as expensive as the contracture test. We have great hopes that, in time, the genetic test will be perfected such that we can determine MH susceptibility with certainty using DNA analysis. But considering that there are over 250 DNA changes or mutations in the one gene that is most associated with MH, there is much more work to do. So, what is missing at present is a minimally invasive test (such as a blood test) that is easy to use, that will detect those who are MH susceptible and then have the susceptibility confirmed by the most specific test available, the DNA test. Several such tests have been proposed in the past, but either they require very expensive complex equipment, require injection of drugs, much time to perform or were not very accurate.
Dr. Saiid Bina and colleagues in the Department of Anesthesiology at Uniform Services University, home of the MH Investigative unit that Dr. Muldoon initiated, reflected on the underlying biochemical changes in MH and hypothesized that since calcium levels are abnormally elevated in MH susceptibles or at the least more easily released from storage organelles than in normals, there should be energy expended to reduce the calcium levels to more normal levels. That energy derives from ATP (adenosine triphosphate) which is produced in the cell through metabolism. If ATP is used at a higher rate than normal then one of the breakdown products of ATP, adenosine, might be elevated in cells. It is possible to measure adenosine in the laboratory without problem, but what cells should be assayed? The cell they chose was one of the white blood cells, the lymphocyte. This made perfect sense because several years ago, Dr. Yoshi Sei who had worked with Dr. Muldoon in the past) demonstrated that lymphocytes release calcium on exposure to such calcium releasing agents as caffeine and halothane. Further, other investigators had shown that certain types of lymphocytes contain ryanodine receptors, identical to the ones in skeletal muscle. Whereas measuring calcium movements in cells over brief periods of time is a complicated affair (and not suitable to a relatively inexpensive clinical test), measuring adenosine levels is far simpler.
Thus, Dr. Bina and collegues first chose MH susceptible pigs, sampling blood and isolating lymphocytes for the measurement of adenosine levels in cells with and without a drug similar to caffeine that releases calcium from storage organelles. The researches compare results between known MH swine and know normal swine. As predicted, they found elevated levels of adenosine in the lymphocytes from the MH pigs as compared to non-MH pigs, with no overlap in values between MH and non-MH animals.
Please bear in mind that this was a preliminary study in animals and will need to be verified in humans in a large number of patients. Nevertheless it is a promising first step toward a test that bridges the gap between the muscle biopsy test and the genetic test. The study was published in Anesthesiology in October, 2010 (see full reference information below).
Something else that I am excited to bring to your attention, because I had a hand in developing it, is an interactive "app" for the iPhone for diagnosis and treatment of MH. The person who did the lion's share of the work on the app is Dr. Thierry Girard who is the director of the MH Investigative Unit in Basel Switzerland. We felt that an app for MH would assist those dealing with a case of MH by reminding the clinician of the many steps needed to diagnose and treat MH. For example, when the clinician enters certain signs such as muscle rigidity and /or unexplained elevation of carbon dioxide levels, the app will prompt the clinician to discontinue the anesthetic agent and will, based on the patient's weight, calculate both the dose and number of vials of dantrolene needed. The app will also calculate the Clinical Grading Scale score used to assess the likelihood of MH. Furthermore a log of events during the episode will be created that can be saved or
emailed. A touch of the screen will also place a call to the hotline. The app is available on I tunes for $4.99. The proceeds will be shared between MHAUS and the European MH group. Dr. Girard has already produced a version of the app in German and we hope to have it translated into other languages. We hope that try it and find it useful. We welcome your feedback.
These are some examples of the advances that are being made by those interested in improving care of MH patients and assisting clinicians in managing this complex disorder.
Reference:Bina S, Capaccione J, Muldoon S, Bayarsaikhan M, Bunger R. Lymphocyte-based determination of susceptibility to malignant hyperthermia: a pilot study in swine. Anesthesiology 2010; 113:917-924.
This item filed in the following categories:


Wales Cottage Holidays visitors to Cardiff are sure to visit the stunning castle and beautiful Bute Park in the centre of the city. Marking an important milestone in the £5.6m restoration of the park, the Castle's outer moat is now being re-flooded.
The watercourse once supplied a corn mill and evidence of local potteries, tanners and metal workers was uncovered when archaeologists excavated the moat, known as Mill Leat, during a restoration project. They found 3,000 items dating back to the 16th Century. Mill Leat contained water until the late 1970s when it was drained, but the restoration has enabled archaeologists to shed light on little known period in Cardiff's history. Artefacts including engraved leather items, a sword sheath, probable Venetian glass as well as pewter spoon and clay tobacco pipe fragments have been uncovered during the recent excavations, and these high-status pieces give a likely link to the former residents of Cardiff Castle during the 16th and 17th Centuries. As well as creating a new freshwater habitat, the re-flooding of the moat will see something from the park's original character returned, bringing another captivating element of the city's history back to life.


text:
Venets of Venec (Bulgaars: Венец) is een dorp en een gemeente in het noordoosten van Bulgarije. Het dorp Venets ligt in oblast Sjoemen.

Geografie
De gemeente Venets is gelegen in het noordwestelijke deel van de oblast Sjoemen. Met een oppervlakte van 209,911 km² is het de kleinste van de 10 gemeenten van de oblast (oftewel 6,19% van het grondgebied). De grenzen zijn als volgt:

in het oosten - gemeente Kaolinovo;
in het zuiden - gemeente Chitrino;
in het westen en noordwesten - gemeente Samoeil, oblast Razgrad.

Bevolking
Op 31 december 2020 telde het dorp Venets 722 inwoners, een stijging ten opzichte van 709 inwoners in 2011. Het aantal inwoners vertoonde in de twintigste eeuw echter een intensieve krimp, met name tussen 1985 en 1992. Het aantal inwoners daalde in die periode namelijk van 1.554 naar 944 personen, oftewel een afname van 39% in slechts 7 jaar tijd. Eind jaren tachtig namen ongeveer 350.000 Bulgaarse Turken de wijk naar Turkije, op de vlucht voor de grote bulgariseringscampagne die in 1985 was begonnen. De assimilatiecampagne, die door het communistisch regime van Todor Zjivkov werd vastgesteld, dwong alle Bulgaarse Turken en andere moslims in Bulgarije Bulgaarse namen aan te nemen en afstand te doen van alle islamitische gebruiken en gewoonten.

Etnische samenstelling
Het dorp Venets wordt nagenoeg uitsluitend bewoond door Bulgaarse Turken (95,7%). Er leven ook een aantal Bulgaarse families, in totaal zo'n 27 personen (ofwel 3,9% van de bevolking).

Ook in de gemeente Venets wonen vooral etnische Turken, maar er is ook een relatief grote minderheid van Roma. De Roma wonen vooral in de dorpen Gabritsa en Izgrev.

Religie
De laatste volkstelling werd uitgevoerd in februari 2011 en was optioneel. Van de 7.137 inwoners reageerden er 5.954 op de volkstelling. Van deze 5.954 respondenten waren er 5.660 moslims, oftewel 95,1% van de bevolking. De rest van de bevolking had een andere geloofsovertuiging of was niet religieus. Venets heeft - samen met Tsjernootsjene, Kaolinovo, Satovtsja en Roeën - het hoogste percentage moslims in Bulgarije.

Gemeentelijke kernen

De gemeente Venets telt 13 nederzettingen, allemaal dorpen.

Gemeente in Bulgarije
Sjoemen (oblast)

redpajama_set_name: RedPajamaWikipedia


Here are the products that are ROI-ing. Typically a few of them fit together to connect what you're doing on a daily basis to the web communication you need to pay attention to ...because your clients demand it.
Many of the products considered "web marketing" are one time jobs. Here are some one time services ...but we can create any product set required to connect with the other end of a screen.