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Home Blog Pityriasis Rubra Pilaris Causes Symptoms Information with Treatment
Pityriasis Rubra Pilaris Causes Symptoms Information with Treatment
Pityriasis rubra pilaris is a rare and chronic skin disorder that often has a sudden onset. Symptoms include reddish orange discolouration scaling, and severe flaking of the skin. Dr. W.A.D. Griffiths has classified six forms of PRP. At this time, the cause of PRP is unknown, and a cure is also unknown. The disease affects persons of all ages, races, and nationalities. Both sexes are affected equally. Many Support Group members report a varied clinical progression of the disease. Pityriasis rubra pilaris is a skin disorder that causes constant inflammation and scaling of the skin. It is generally accompanied by elevated erythematous spots (papules) on the skin. The papules are the most important diagnostic feature, being more or less acuminate, reddish brown, about pinhead size, and topped by a central horny plug. Pityriasis rubra pilaris most often starts as a patchy rash on the scalp, face or chest. Over a period as short a several weeks it extends downward, and often covers much of the body. It spares areas of old scars and injuries, and leaves small islands of entirely unaffected skin. The rash has an orange-red color and the palms and soles become thickened. Rough, dry plugs can be felt within the rash. The itching is usually severe at first, and then later is not as bad as you would think considering how bad the rash looks. The best treatment is Accutane or Soriatane pills. These are closely related "retinoid" medications. While these have many minor side effects, they do not usually cause any serious harm to the body. A more potent and more effective treatment is methotrexate tablets, but as these can have dangerous side effects they are saved for people who don't improve with the retinoids.
Pityriasis rubra pilaris is the name given to a group of rare skin disorders that present with reddish-orange coloured scaling patches with well defined borders. The disease may affect entire body or just restrict to some parts such as the elbows and knees, palms and soles. The Disease generally produces elevated spots on the skin. These spots grow and become connected, producing red plaques over large areas containing dry plugged pores. It is found to be having association with abnormal metabolism of vitamin A. It could take as long as one to three years for an individual to fully recover from this skin disorder. It may occur in any race, and both male and female are equally affected. -The cause of pityriasis rubra pilaris is unknown. The 2 most common forms of the disease are juvenile classic, characterized by autosomal dominant inheritance and childhood onset, and adult classic, characterized by no apparent inheritance and adult onset. Atypical forms exist in both age groups. Sunlight can trigger a flare. Diagnosis is by clinical appearance and may be supported by biopsy. Differential diagnosis includes seborrheic dermatitis (in children) and psoriasis when disease occurs on the scalp, elbows, and knees.
Causes of Pityriasis Rubra Pilaris
Find common causes and risk factors of Pityriasis Rubra Pilaris :
Pityriasis Rubra Pilaris is generally sporadic, but in some forms it may be partially inherited.
Fungal infection may also be a cause of the disease.
Signs and Symptoms of Pityriasis Rubra Pilaris
Sign and symptoms may include the following :
Seborrhea of the scalp.
Pink swellings.
Lesions of the face.
Scaling lesions.
Itchy.
Rashes.
Treatment for Pityriasis Rubra Pilaris
Treatment may include :
Steroid creams and ointments may also be used to remove the rashes.
Methotrexate a strong drug used for suppressing the immune system may be used as a treatment for pityriasis rubra pilaris, but it too has many side effects.
Topical medications such as emollients may be used to get relive from dryness and cracking.
Treated with a derivative of vitamin A known as acitretin also useful in Pityriasis rubra pilaris but the treatment has some severe side effects.
Accutane or Soriatane pills are the best treatment .


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Q: FailedPreconditionError when running output layer in session? In tensorflow, I am experiencing an issue where I try to get the output of my last neuron by running it in a session but it gives me an error. I am running Python 3.8.5 and TensorFlow 1.15 (because of some hardware issues)
Here is my code:
import warnings
warnings.filterwarnings("ignore")

import numpy as np
import tensorflow as tf

def main():
    x_inputs = tf.Variable(np.array([[1, 2 ,3], [1, 2, 3]]), dtype=tf.float32)
    y_outputs = tf.Variable(np.array([[1, 2, 4], [2, 3, 4]]), dtype=tf.float32)
    model = create_model(x_inputs, y_outputs)

def create_model(x: np.array, y: np.array):
    var_init = tf.global_variables_initializer()

    with tf.Session() as sess:
        sess.run(var_init)

        x_val = sess.run(x).flatten()
        y_val = sess.run(y).flatten()

        # neural network architecture
        input_layer = tf.layers.dense(x, units=len(x_val), activation=tf.nn.sigmoid)
        hidden_layer = tf.layers.dense(input_layer, units=5, activation=tf.nn.relu)
        output_layer = tf.layers.dense(hidden_layer, units=2, activation=tf.nn.softmax)

        print(sess.run(output_layer))

if __name__ == "__main__":
    main()

Here's the error:
Traceback (most recent call last):
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/client/session.py", line 1350, in _do_call
    return fn(*args)
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/client/session.py", line 1327, in _run_fn
    return tf_session.TF_Run(session, options,
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/framework/errors_impl.py", line 470, in __exit__
    raise _make_specific_exception(
tensorflow.python.framework.errors_impl.FailedPreconditionError: Attempting to use uninitialized value dense_2/bias
     [[Node: dense_2/bias/read = Identity[T=DT_FLOAT, _class=["loc:@dense_2/bias"], _device="/job:localhost/replica:0/task:0/device:CPU:0"](dense_2/bias)]]

During handling of the above exception, another exception occurred:

Traceback (most recent call last):
  File "learning.py", line 29, in <module>
    main()
  File "learning.py", line 10, in main
    model = create_model(x_inputs, y_outputs)
  File "learning.py", line 26, in create_model
    print(sess.run(output_layer))
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/client/session.py", line 894, in run
    result = self._run(None, fetches, feed_dict, options_ptr,
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/client/session.py", line 1127, in _run
    results = self._do_run(handle, final_targets, final_fetches,
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/client/session.py", line 1343, in _do_run
    return self._do_call(_run_fn, self._session, feeds, fetches, targets,
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/client/session.py", line 1363, in _do_call
    raise type(e)(node_def, op, message)
tensorflow.python.framework.errors_impl.FailedPreconditionError: Attempting to use uninitialized value dense_2/bias
     [[Node: dense_2/bias/read = Identity[T=DT_FLOAT, _class=["loc:@dense_2/bias"], _device="/job:localhost/replica:0/task:0/device:CPU:0"](dense_2/bias)]]

Caused by op 'dense_2/bias/read', defined at:
  File "learning.py", line 29, in <module>
    main()
  File "learning.py", line 10, in main
    model = create_model(x_inputs, y_outputs)
  File "learning.py", line 24, in create_model
    output_layer = tf.layers.dense(hidden_layer, units=2, activation=tf.nn.softmax)
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/layers/core.py", line 253, in dense
    return layer.apply(inputs)
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/layers/base.py", line 762, in apply
    return self.__call__(inputs, *args, **kwargs)
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/layers/base.py", line 636, in __call__
    self.build(input_shapes)
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/layers/core.py", line 139, in build
    self.bias = self.add_variable('bias',
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/layers/base.py", line 498, in add_variable
    variable = vs.get_variable(name,
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variable_scope.py", line 1256, in get_variable
    return get_variable_scope().get_variable(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variable_scope.py", line 1091, in get_variable
    return var_store.get_variable(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variable_scope.py", line 429, in get_variable
    return _true_getter(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variable_scope.py", line 399, in _true_getter
    return self._get_single_variable(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variable_scope.py", line 798, in _get_single_variable
    v = variables.Variable(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variables.py", line 220, in __init__
    self._init_from_args(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/variables.py", line 376, in _init_from_args
    self._snapshot = array_ops.identity(self._variable, name="read")
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/array_ops.py", line 127, in identity
    return gen_array_ops.identity(input, name=name)
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/ops/gen_array_ops.py", line 2133, in identity
    _, _, _op = _op_def_lib._apply_op_helper(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/framework/op_def_library.py", line 785, in _apply_op_helper
    op = g.create_op(op_type_name, inputs, output_types, name=scope,
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/framework/ops.py", line 3152, in create_op
    ret = Operation(
  File "/Applications/anaconda3/lib/python3.8/site-packages/tensorflow/python/framework/ops.py", line 1625, in __init__
    self._traceback = self._graph._extract_stack()  # pylint: disable=protected-access

FailedPreconditionError (see above for traceback): Attempting to use uninitialized value dense_2/bias
     [[Node: dense_2/bias/read = Identity[T=DT_FLOAT, _class=["loc:@dense_2/bias"], _device="/job:localhost/replica:0/task:0/device:CPU:0"](dense_2/bias)]]

Please help me I'm really struggling.
Thanks in advance!

redpajama_set_name: RedPajamaStackExchange


text:
Torslanda HK G13 1
In addition to the three Torslanda teams, 107 other teams from 14 different countries played in Girls 13. They were divided into 18 different groups, whereof Torslanda HK 1 could be found in Group 8 together with HG Bremerhaven, HK Aranäs 4, IF Stjernen 1, Haslum IL 2 and HK Ankaret 2.
Torslanda HK 1 continued to A-Play-off after reaching 2:nd place in Group 8. In the playoff they made it to 1/32 Final, but lost it against Vorup FB 1 with 13-14. In the Final, Rödovre HK won over Handbalschool Brabant and became the winner of A-Play-off in Girls 13.
Torslanda HK also participated in Girls 12 during Partille Cup 2018. They reached the 1/16 Final in G12 A-Play-off, but lost it against Lilleström HK 2 with 9-14.
1.	 IF Stjernen 1 5 5 0 0 71 42 (29) 10
2.	 Torslanda HK 1 51 20 11 20 6811 6611 (2)(0) 51
3.	 Haslum IL 2 51 20 11 20 6111 5511 (6)(0) 51
4.	 HK Aranäs 4 51 21 00 30 5713 6711 (-10)(2) 42
5.	 HG Bremerhaven 51 20 00 31 5011 5913 (-9)(-2) 40
6.	 HK Ankaret 2 5 1 0 4 48 66 (-18) 2
Torslanda HK 1 - IF Stjernen 1 7 - 12 10:15 Heden 22 G13 Grp 8 02002503
Torslanda HK 1 - HG Bremerhaven 13 - 16 12:00 Heden 25 G13 Grp 8 02003006
Haslum IL 2 - Torslanda HK 1 11 - 11 10:15 Heden 12 G13 Grp 8 03001503
HK Ankaret 2 - Torslanda HK 1 16 - 21 12:00 Heden 21 G13 Grp 8 03002406
HK Aranäs 4 - Torslanda HK 1 11 - 16 16:50 Heden 22 G13 Grp 8 04002514
Vorup FB 1 - Torslanda HK 1 14 - 13 10:15 Heden 25 G13 A-Play-off 1/32 Final 05003003

redpajama_set_name: RedPajamaCommonCrawl


This page presents the Google satellite map (zoomable and browsable) of Glen nui in Taranaki district in New Zealand.
Geographical coordinates are -39.4434 and 174.4767 and its feature type is Hstd. More information below.


And then with everyone together to make an even bigger one! The longer the line, the bigger the spiral!
Adult Challenge of the week: Use the vocabulary word "spiral" when talking to your kids today. It is a VERB and a NOUN!
Hindsight Tip: We needed more of a variation in our natural spirals to press into the dough. It would have been better to be more prepared (sigh, like always) to have some other flowers, shells, or even succulents we could use to press since it was a very popular activity!
I would love to try this Spiral pendulum! And the exploration of man made spirals might be fun too. Possibly a pipe cleaner or wire activity for bending spirals?


text:
All of my search terms
Any of my search terms
TMAD83
View Profile View activity
I just unlocked the third set of tracks in Polaris SnoCross
TMAD83 posted a topic in Ross's Game Dungeon
When I saw a PC copy of this game at a thrift store a few years ago I decided to try it and see if I could make it further than Ross. I played the game on Linux using wine and it ran just fine. After playing the game off and on for 3 years I found out that it is possible to advance in this game but it is very hard. For reference I was once ranked in the top 2% of Forza 4 players, and even then I still used a lot of luck to win. What I found was that the game favors the green racer above all others. I won because I was able to crash that racer near the end of the finish in the first race and he finished last. Even when this happens the racer will still be in the front of the others in the next race. So I won the first race, he finished last. I came second in the 2nd race and he finished first. The third race I won and he came third. I came last in the last race but because of how the AI favors the green racer I was able to win the tournament by 2 points. I tried recording footage of this but there was a glitch and the recording was ruined. I was able to get a screen shot of the final score table though.
Birthday thread: Soundtracks
TMAD83 replied to Ross Scott's topic in Soundtracks
The main theme for Nexuiz (GPL) is pretty good.
ROSS'S GAME DUNGEON: BATTLEFORGE
TMAD83 replied to Ross Scott's topic in Ross's Game Dungeon
There are some people who care but it seems there are not enough people to make a difference though. edit: sorry if it seems like I am ranting
The thing is in order for this practice to change people have to care. I was complaining about a game being shut down on another website and the people on there said that "it was 10 years old it lived long enough." We can inform people all we want that does not mean that they will listen or care enough to do anything.
The games that EA killed that I am still upset about are the Battlefront games. They just shut the servers down, and now the new one is online only, I guess that they don't want me to play the new one. I talk to people I know about this and they say "those games are old" well tell that to all of the people playing Quake 3.
ROSS'S GAME DUNGEON: WOLFENSTEIN
Just wanted to say that the Hogan's Heroes reference was awesome.
FREEMAN'S MIND: EPISODE 65
TMAD83 replied to Ross Scott's topic in Freeman's Mind
"The sound of coming to terms with your own stupidity" I have a new favorite Freeman quote.
I never knew that there was a tunnel underneath the island to get to the rotating platforms. It took me 10 tries to get up there.
Just wanted to say great episode Ross. I just can't wait to see which ending that you choose to do. But based off of the portrayal of Freeman so far I think he will choose to take G-Man's offer.


The internet has been buzzing about the New York Fashion Week for months and BOY did it come to a climax! Designers really have outdone themselves this year with their sharp, fresh take on fashion for the rest of the year. I'm not one to follow fashion trends but I was pleasantly surprised by what I saw!
Michael Kors: I love the blunt red colour that echoed throughout Kors collection.
Michael Kors: Kors always has a stunning evening wear and he didn't fail to impress with this gorgeous, sequinned, red number.
Jenny Packham: I've never come Jenny Packham's designs before but I am in LOVE LOVE LOVE! Her designs ooze sophistication and this tailored dress is absolutely gorgeous!
Jenny Packham: This pale blue dress is beautiful. I adore how the dress is draped around the model. The crystal detail at the top adds an extra dimension to the dress. This design is going ti infiltrate down to the High Street in no time.
Marc Jacobs: I am a massive Jacobs fan and I LOVE this dress. It is hard, edgy and grungy but the soft make-up adds a subtly femininity to it. It is a reflection of looks gone by but why fix something that isn't broken?
Marc Jacobs: Metallics are here to stay!!!
Oscar Le Renta: Oscar Le Renta's dresses need to introduction so just enjoy these next few pictures.
Tory Burch: I really like the material of this dress. It is tailored without being too structured, and floaty at the same time. Burch's colour palette for this collection is a lot of dark, sombre colours which is different and sets her aside from some of the other designers.
Tory Burch: It was refreshing to see something on the catwalk that I could see myself wearing to work.
Whitney Port: Port has had a lot of criticism for her new collection but I actually really like it. She has pieces of clothes that I can see myself wearing and actually investing in. This neutral coloured dress, in particular, made me fall in love with her designs because of its simplicity yet statement look.
I cannot wait till these looks infiltrate into the High Street.
What new fashion statements are you excited about?


At Violin Outlet, we believe that each player is unique. It is our goal to find the best possible viola for each individual. The instrument must meet or exceed the player's current needs at an affordable price. We carry several levels of violas to accommodate a complete beginner as well as a professional.
Read more about Violas to learn about the origin of the instrument.


Luciana Francois is beautiful little girl who likes to jump rope and play with dolls.
I got the pleasure of meeting Luciana last week working with the Salisbury Team. She is precious and I will never forget her sweet smile. We share a birthday so she has a special print on my heart.


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Rockstars That Worked In The Food Industry Before Being Legends
David Bowie on his Live Aid Set, 1985 - Live Aid / Youtube
Some of our favorite rockstars had their fair share of normal and odd day jobs before making it big in the music scene. Some of them did these jobs to keep surviving, earn quick bucks, or continuing the way of life of their parents or guardians. Whatever their reasons may be, its quite humbling to know how some of the biggest rock icons started out with small-time, low pay jobs. But hey, as long as you aren't doing illegal stuff, all's cool. Here are some rockstars who have experience in the food industry as day jobs, before breaking out to become legends.
David Bowie – Butcher Delivery Boy
Even the elegant and magnificent Lord of Personas started out with a day job. As a young lad, Bowie was already into music, primarily due to Little Richard's influence. He worked as a delivery boy for a local butcher to save up for a saxophone which he sought after with purpose at the time.
Ozzy Osbourne – Slaughterhouse Assistant
The Prince of Darkness was involved in a trade that even he couldn't stomach. Ozzy Osbourne worked several day jobs, but none as bizarre in his time as a slaughterhouse assistant. "I had to slice open the cow carcasses and get all the gunk out of their stomachs… I used to vomit every day. The smell was something else", Ozzy shares.
Tom Waits – Pizza Maker
American rocker Tom Waits worked at the Napoleone Pizza House in San Diego at the young age of 14. Waits was initially a dishwasher, but was eventually promoted to cook status. "He started when he was in high school, about sixteen years old. He was shy at first, but I think that was just because he was young. He washed dishes, and then he became a cook. He was an excellent worker. He made good pizzas," Owner Sal Crivello shares.
Chris Cornell – Fish Handler
Soundgarden and Audioslave's Chris Cornell was cleaning fish before he filled stadiums. The late frontman shared his experiences, "I did it for years, from my early teens on. My job was to wipe up the slime and throw away the fish guts. I met pretty much every sous-chef in town because they would come in and look around at what we had. I think we had the best wholesale seafood in town. The owner was impeccable about it."
Wayne Coyne – Fry Cook
Wayne Coyne of the American rock act The Flaming Lips waited a decade before the band finally acheived mainstream success. To kill time and supplement his expenses, Wayne Coyne worked as a fry cook at Long John Silver's. "In the beginning, it seemed like a dead-end job. But at least I had a job. And frankly, it was easy. After two weeks, I knew all I needed to know, and it freed my mind. The job allowed me to dream about what my life could become."
Do you know of other famous rockstars who was in the food business before being legends? Share them on the comments!


DAVENPORT, Iowa -- A blind man gets the gift of a lifetime - his sight back.
It's been nearly a decade since David Hereid Jr. has been able to see, but thanks to new electronic glasses - now he can.
"My dad sat here all morning yesterday wearing a red shirt," David said. "Until I put the glasses on I didn't know he was wearing a red shirt."
David is legally blind. He said most of what he sees is a blur, so he uses the minimal peripheral vision he has. However, David's life was not always this way. David's father, Dave Hereid Sr., said his son used to be a volunteer firefighter in Long Grove and Bettendorf and an EMT in Galesburg. Dave said David's biggest concern after going blind was how he could ever help people again.
"When he lost that ability it was just heartbreaking for him," Dave said. "He lost all of that and I can't tell you how heartbreaking that was for him and for me."
"I had 20/20 vision," David said. "And I was building the deck one day, I went to bed that day and woke up to a painful eye."
Unfortunately, what doctors thought could be fixed with simple eye drops was actually a rare disease called Multifocal Choroiditis. David's own body had started to attack the white blood cells in his eyes. A disease so uncommon, David said, it affects less than 1% of the world's population.
Still, he admits the moment was bittersweet.
"There's some mixed feelings," David said. "I got custom to this life without them. I've adapted and overcome a lot of trial and error… So it was the end of a chapter, but its beginning of a new one. And we're on page one of that chapter."


text:
Lebanon Plans to Fight Covid-19 without Financial Assistance from IMF
Posted on March 3, 2020 February 22, 2022 by Raina
Officials have confirmed more than 475 cases and approximately 12 deaths in Lebanon. Although Lebanon is in deep financial and political crisis, it has different plans to generate funds and cope with this serious problem than to acquire financial assistance from the IMF.
On-going cases of Covid-19 are increasing at a rapid rate on a global scale. The total number of cases has crossed 859,000, with more than 43,270 reported deaths. The spread has also ramped in Lebanon, and more than 475 cases approximately and 12 deaths have been officially confirmed. The government has announced partial lockdown to control the widespread infectious disease and declared a state of medical emergency.
Lebanon had already banned flights from China, Italy, and Iran, and it is shutting down all airports to restrict movement over coronavirus. The state has requested the citizens to stay at home unless they have critical reasons. Currently, Lebanon is dealing with several financial and non-financial issues to control the spread and impact of Covid-19.
The IMF has stated that it will fully support every country affected by coronavirus via Rapid Financial Instrument. The spokesperson of IMF Gerry Rice expressed condolences to the victim of the Covid-19 after its outbreak in China and shared his insights on how it will impact the Chinese and global economy. He further added that currently, they would only be providing 'technical assistance' to Lebanon and no financial aid.
Lebanon has a partnership with the IMF for its technical expertise, and this is all the country plans to take from it. Chief of Iranian Central Bank, Abdolnaser Hemmati, has already contacted the IMF for funding of $5 billion to help the country fight and protect its citizens from deadly coronavirus. The country has lost over 3,000 lives, and its war with the US had already weakened its economy.
Although Lebanon itself is in deep financial and political crisis, it has different plans to generate funds and cope with this serious problem. It has announced to use its funds to fight the COVID-19 pandemic and is currently working on arranging new finances to control the country's economy. The United Way of Lebanon and other organizations have proven quite useful in generating funds at such a time of dire need.
It has launched a special fund to financially support the residents who are struggling with the coronavirus. It has requested everyone in and outside Lebanon to make donations to this cause on its online platform.
The funds collected will be circulated through community nonprofits channels. This way, monetary assistance will be provided to all needy families. There is a high number of requests for aid as people deal with closed businesses, banks, schools, and childcare centers, and have an urgent need for healthcare.
Officials have confirmed 12 corona deaths in the country, with 430 patients under treatment. This number is expected to rise unless strict precautions are taken. This virus is not just a threat to the health of the people; it's a threat to the economy as well. While developed and rich countries won't have much trouble recovering from this trauma, Lebanon will have to face a big economic challenge after they have dealt with the current one.
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text:
signal transduction and targeted therapy
Targeting NR4As, a new strategy to fine-tune CAR-T cells against solid tumors
Feng Li1 &
Yi Zhang1
Signal Transduction and Targeted Therapy volume 4, Article number: 7 (2019) Cite this article
Cancer therapy
In a recent report in Nature, Chen et al.1 identified the critical transcription factors that drive T-cell dysfunction. Knockout of these transcription factors to augment T-cell activity represents a new approach to enhancing the effectiveness of chimeric antigen receptor T (CAR-T) cell therapy for solid tumors.
CAR-T cells are designer cytotoxic lymphocytes with recognition specificity and tumoricidal potency. Although CAR-T cells exhibit unprecedented effectiveness in treating hematologic malignancies, these cells have limited efficacy against solid tumors.2 Therefore, intensive efforts have been made to augment the efficiency of CAR-T cell therapy for solid tumors.
A major barrier in solid tumors is the hostile microenvironment surrounding CAR-T cells. To overcome the immunosuppressive effects within the tumor niche, several tactics have been undertaken. The administration of programmed cell death protein 1 (PD-1) antibodies is effective in restoring CAR-T cell function.3 Recently, CAR-T cells armed with a secreted minor fragment derived from the variable domains of a PD-1-blocking antibody were tested.4 This design seemed more efficient to augment the functionality of host and nearby T cells than did the full-length antagonist. Soluble transforming growth factor-β (TGF-β) is also important for inhibiting T-cell activation. By introducing signal-switch receptors comprising the TGF-β-binding ectodomain and the T-cell activation endodomain, CAR-T cells are more potently activated in the tumor microenvironment.5 The suppressive immune cells represent another obstacle for CAR-T cell therapy. With enforced expression of interleukin (IL)-18, CAR-T cells are more active against tumors by decreasing the populations of suppressive regulatory T (Treg) cells and M2 macrophages.6
T-cell differentiation is also the determinant for therapeutic efficacy. Less differentiated T cells have better persistence in vivo. Nevertheless, a large portion of T cells are terminally differentiated during CAR-T cell production. To augment the populations of more proliferative T cells with stem-cell-like or memory phenotypes, specific supplements were added in culture. The addition of IL-7 and IL-15 but not IL-2 induces the generation of more memory cells without compromising the cytotoxic function.7 Similarly, supplementation with a phosphoinositide 3-kinase-δ (PI3k-δ) antagonist shows promise in preserving memory subsets during CAR-T cell expansion.8 Alternatively, an infusion with naive T cells, which subsequently differentiate in vivo, may result in better clinical responses. The combination of CAR-modified induced pluripotent stem cells (iPSCs) and organoid-dictated T-cell lineage commitment makes this hypothesis possible. A previous group established such an approach to produce naive CAR-T cells,9 which may introduce new scenarios in treating tumors.
Recently, a report published in Nature proposed a new strategy to improve CAR-T cell therapy.1 To avoid autoimmunity, various transcription factors are upregulated to limit the intensity and interval of T-cell activation. Such factors will upregulate the expression of inhibitory receptors, subsequently induce terminal differentiation and downregulate the secretion of inflammatory cytokines. Hence, finding the key intrinsic initiator of T-cell dysfunction can provide new targets for the preparation of upgraded CAR-T cells. Chen et al.1 uncovered NR4A1, NR4A2 and NR4A3 as the central transcriptional factors that drive T-cell dysfunction. To identify the intrinsic triggers of exhaustion, these authors checked the transcriptional adaptations between functional and hypofunctional CD8+ T cells. By analyzing single cell transcriptome and chromatin accessibility, the researchers discovered that the transcription factors NR4A1, NR4A2 and NR4A3 were upregulated and played critical roles in mediating CD8+ T-cell exhaustion in mouse CAR-modified and endogenous lymphocytes and their human counterparts exposed to tumor or chronic virus infection. When all three NR4As were deficient, the activated CD8+ T cells demonstrated features resembling effector T cells with increased functionality rather than those with an exhausted status. Additionally, the researchers generated CAR-T cells with a deletion of NR4As. Compared with their wild-type counterparts, the NR4A-deficient CAR-T cells showed enhanced cytotoxicity but decreased inhibitory receptor expression and promoted tumor regression more significantly.
This finding provides us with new candidate targets to augment the cytotoxic capacities of CAR-T cells during chronic antigen engagement, which supplements the approaches that help to improve the effectiveness of adoptive transfer therapy for solid tumors (Fig. 1).
Strategies to augment chimeric antigen receptor T (CAR-T) cell activity in treating solid tumors. Dysfunction of CAR-T cells is related to many intrinsic and extrinsic factors (right). Maintenance of the proliferative T cells and reversion of the inhibition signals are reasonably needed to sustain CAR-T cell function within the tumor (left). Manipulation of the genes that exacerbate T-cell exhaustion is also effective in improving the efficacy of CAR-T cell therapy (left)
Chen, J. et al. NR4A transcription factors limit CAR T cell function in solid tumours. Nature https://doi.org/10.1038/s41586-019-0985-x (2019).
June, C. H. & Sadelain, M. Chimeric antigen receptor therapy. N. Engl. J. Med. 379, 64–73 (2018).
Cherkassky, L. et al. Human CAR T cells with cell-intrinsic PD-1 checkpoint blockade resist tumor-mediated inhibition. J. Clin. Invest. 126, 3130–3144 (2016).
Rafiq, S. et al. Targeted delivery of a PD-1-blocking scFv by CAR-T cells enhances anti-tumor efficacy in vivo. Nat. Biotechnol. 36, 847–856 (2018).
Sukumaran, S. et al. Enhancing the potency and specificity of engineered T cells for cancer treatment. Cancer Discov. 8, 972–987 (2018).
Chmielewski, M. & Abken, H. CAR T cells releasing IL-18 convert to T-Bet(high) FoxO1(low) effectors that exhibit augmented activity against advanced solid tumors. Cell Rep. 21, 3205–3219 (2017).
Xu, Y. et al. Closely related T-memory stem cells correlate with in vivo expansion of CAR.CD19-T cells and are preserved by IL-7 and IL-15. Blood 123, 3750–3759 (2014).
Abu Eid, R. et al. Enhanced therapeutic efficacy and memory of tumor-specific CD8 T cells by ex vivo PI3K-delta inhibition. Cancer Res. 77, 4135–4145 (2017).
Montel-Hagen, A. et al. Organoid-induced differentiation of conventional T cells from human pluripotent stem cells. Cell Stem Cell 24, 376–389.e8 (2019).
Biotherapy Center and Cancer Center, The First Affiliated Hospital of Zhengzhou University, Zhengzhou, Henan, China
Feng Li & Yi Zhang
Feng Li
Yi Zhang
Correspondence to Yi Zhang.
Li, F., Zhang, Y. Targeting NR4As, a new strategy to fine-tune CAR-T cells against solid tumors. Sig Transduct Target Ther 4, 7 (2019). https://doi.org/10.1038/s41392-019-0041-1
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Signal Transduction and Targeted Therapy (Sig Transduct Target Ther) ISSN 2059-3635 (online)


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Board Index > General Chat > Whipping Post > Officially Declared Democrat 2020 POTUS Candidates
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Author: Subject: Officially Declared Democrat 2020 POTUS Candidates
posted on 3/6/2019 at 04:53 PM
How has been spending his millions and millions in campaign contributions from his duped supporters.
You can't use leftover campaign contributions for personal spending. Against Federal law since 1989.
John Hickenlooper (announced 3/4/19)
- 67, two-term Governor of Colorado, former Mayor and entrepreneur
https://www.hickenlooper.com/
Jay Inslee (announced 3/1/19)
- 68, two-term Governor of Washington, former state legislator
https://jayinslee.com/
Hillary Clinton, officially not running.
Michael Bloomberg, not running.
Eric Holder, not running.
Jeff Merkley, not running.
Mr. Bloomberg said he felt his time and personal fortune would be better used promoting immigration reform, gun control and climate change. Mr. Holder wants to continue focusing on ending gerrymandering. Mrs. Clinton, who never seriously pursued a third primary bid, said she would keep "standing up for what I believe." And Mr. Merkley will seek a third term in the Senate in 2020, after the State Legislature rejected his request to allow him to run for both positions simultaneously.
"I believe I would defeat Donald Trump in a general election," Mr. Bloomberg wrote in a column published Tuesday. "But I am cleareyed about the difficulty of winning the Democratic nomination in such a crowded field."
Kirsten Gillibrand and Pete Buttigieg remain in exploratory status.
[Edited on 3/6/2019 by nebish]
I heard a great interview with Pete Buttigieg a week or two ago. He seems to have some great ideas and given he's a mayor that runs a fairly large city, knows how to actually govern beyond simply introducing and pushing legislation.
He's very smart, articulate, a veteran, a gay man, progressive, and very accomplished via his own merit and effort. In other words, everything Donald Trump is not. A great candidate it seems to me and a serious threat to established Democrats from the Senate and House.....
The early primaries will shake out a number of the Dems' crowded field candidates. California has moved up its primary to March, and this seems like a benefit for Kamala Harris.
The name of the game is money and name recognition. Some of the candidates are going to be challenged in these areas. Running & putting an organization together isn't cheap.
[Edited on 3/6/2019 by MartinD28]
nebish
Maximum Peach
posted on 3/15/2019 at 10:43 AM
Beto O'Rourke (announced 3/14/19)
- 46 years old, former US House member from Texas 2013-2019, lost 2018 US Senate election, formerly served on El Paso city council
https://betoorourke.com/
BrerRabbit
Sublime Peach
[Edited on 3/15/2019 by BrerRabbit]
A truly disturbing idea just occurred to me : What if the backlash produces a liberal version of Trump? Can you even picture whar a creature that would be? Man man oh man - we haven't hit bottom yet.
Kirsten Gillibrand (announced 3/17/2019)
- 52, current US Senator from New York (replaced Hillary Clinton's seat and was reelected twice), former member of US House, lawyer
https://kirstengillibrand.com/
Not a Presidential candidate but suprising nonetheless
https://www.msn.com/en-us/news/politics/former-cia-spy-valerie-plame-set-fo r-senate-run-as-democrat/ar-BBVoMvV
From the archives.
https://www.youtube.com/watch?v=nAgJAxkALyc
1st qrt fund raising. Required to report by 4/15, some reported early:
Buttigieg (still exploratory status): The 37 year-old mayor of South, Bend Indiana is gaining traction on the national stage, and raised $7 million in 2019's first quarter.
Harris: Raised a total of $12 million from 218,000 donors who gave an average of $55 since announcing her candidacy in January, her campaign said.
O'Rourke: Former Texas Congressman Beto O'Rourke announced raising $9.4 million in the first 18 days of his candidacy, an average of $522,000 per day. His campaign said the average donation size was $43, and 98% of contributions were under $200.
Sanders: Announced bringing in $18.2 million from 525,000 contributors, 99.5% of whom gave $100 or less, in the first six weeks of his campaign.
Yang: Entrepreneur and long-shot presidential candidate Andrew Yang reported raising $1.7 million from 80,000 donors who donated an average of just $17.92 in March and February alone, far outpacing the $659,000 he raised between October 2017 and December 2018
https://www.businessinsider.com/how-much-money-2020-democrats-candidates-ha ve-raised-fundraising-2019-4
Tim Ryan (announced 4/4/19)
- 45, current and 9 term member of the US House from Ohio, former congressional aide and state Senator
https://timryanforamerica.com/
posted on 4/5/2019 at 09:15 AM
Curiously arrested for B&E and Drunk Driving, that will be fodder during any possible debate...
Maybe he and the "Groper" Joe Biden can team up?
BoytonBrother
World Class Peach
Are you ever not a jerk towards Democrats? Grow up already.
Did he grab them by the pu$$y like your guy, Mafia Don?
Remember Martin, just because he never complains about Trump, and just because he said that nothing Trump says or does bothers him, it doesn't mean Trump's his guy. His guy is Gary Johnson. I guess he's just a misunderstood guy.
Yes, the President is responsible for some pretty crass behavior, and pretty foul language.
You guys laugh at the President, I will chuckle at the list of contenders.
Tim Ryan serves the district north of me. He took over for the very popular Jim Trafficant, a name that I'm sure most following national politics will remember. Say what you will about Trafficant, but this area loved him and he did alot for it as well. Ryan doesn't enjoy the same widespread support across party lines and doesn't have a strong resume, but still has strongly held that seat since with no serious challengers. The base there is staunchly Democrat, in fact, Trumbull county (where Ryan was born) and within his current district voted for non-incumbent Republican Presidential candidate for the first time in like almost 90 years when Trump took the area in 2016.
Looking towards his prospects to win the nomination, he would be best served to moderate towards the middle and be the working man's candidate...the union blue collar people in this area and the ones that Ryan is going to say he represents do not care about gay rights, or protections for illegal immigrants, or green energy, or whatever the hot left issue of the day is. If he could be middle of the road on some of the more liberal issues and speak to the concerns of blue collar workers like Bernie and Trump did in 2016 I think he could do well.
Problem is that isn't who he is, he has picked up the flag and carried it for the party while he has tried to make a name for himself among the national base. All while he likely could never win state-wide office outside of his protected pocket of loyal Democrat voters.
Sherrod Brown on the other hand would've been an immensely better candidate out of Ohio than Ryan.
I think Ryan sees himself as filling a void among the current crop of candidates, I just don't know where his traction is really going to be. Based off of his career and accomplishments he has little to point to as "why him".
If by "chuckle" you mean "being a complete jerk to people based on their political affiliation", then yes, you "chuckle".
Nothing to do with Biden. Is Joe a little to "touchy/feely" or not?...Yes or No?
"Was 'Beto'... arrested for those two crimes?" Yes or No?
Harris/Buttigiege makes for a compelling Dem ticket in 2020...Covers close to every demographic in the ever expanding progressive wing of the Democratic party.
Of course it'll make every right wing conservative voter sh@t their pants and come to the polls, but what the hell....The Dems have the numbers in their favor if their base actually votes.
Remember total number of votes don't matter. Is that a ticket that the purple states (Midwest and Florida) would vote for? That's all that matters.
I do in fact think the purple states could vote for such a ticket. If the Dems show up and vote and enough independents swing in their favor. It's all about turnout and I think Harris and Butti are compelling enough to energize just enough independents to swing the purple states. If, if, the Dem base go to the polls....
I think Butti has proven exactly that with his election as mayor in a pretty conservative part of Indiana.
I think I get BIGV's point. It took me a while because of how childish and demented it is, but I think I might get it: Because liberals preach tolerance of new ideas, they therefore should never criticize someone for their ideas. For if they do, they are nothing but hypocrites. Therefore, when liberals bash a guy who tries to hurt people everyday on Twitter, they are hypocrites for not tolerating a bully. In return, BIGV bullies and name-calls Biden, AOC, O'Rourke, migrants, and countless others in an attempt to equate the two behaviors. If liberals on this site don't like his comments, then they should tolerate Trump's daily vicious attacks on fellow Americans.
In BIGV's mind, standing up to scum bag behavior is the same as name-calling Democrats because of their political views.
I can't help but feel sorry for someone with such limited intelligence and awareness.
Remember total number of votes don't matter
On the contrary, it matters a lot. The total number of votes in each state determine who carries said group and because of this system, all of the States have equal representation, just like they do in the Congress and the Senate. The total amount of votes in each county ordain who should be Sheriff and so on. The total number of votes in one city elects a Mayor and so on. Don't like how laws in your State apply to you?..Move. Taxes too high in California?...relocate. Think there should be one voice in Government?...Disagree, the Electoral College is absolutely necessary.
Turning to the thread title, this is one of many reasons I laugh at Beto O'Rourke as a viable candidate for POTUS. Arrested for DWI and Burglary (Not a good start, or it that unfair to bring up? lol) He believes the Electoral College was a "Bad Compromise". He opposes more Border security, is against Deportation, is for the Dream act and is against the separation of families and voted no on a Bill that would have eliminated "Sanctuary States" yet it is the Democrats whom claim that Border security is a "Problem".
No Electoral College? One vote for everyone!...
Even if they've entered Illegally.
"My Guy" lol...Repeatedly, I have stated on this board that I voted for Gary Johnson. Perhaps, to further clarify that point, I could start defending the positions Mr. Johnson and the Libertarian Party take whenever a Political hot button is pressed. No wait, I find it much more satirically entertaining to laugh at the views posted by the left/democrats who still can not deal with the everyday reality that they lost the WH, and continue to whine about it.


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That shrimp you're eating could have traces of cocaine, pesticides
By Gary Dinges gdinges@gatehousemedia.com
May 13, 2019 at 2:12 PM May 14, 2019 at 11:42 AM
Researchers say they've found traces of cocaine and pesticides in shrimp.
The study, conducted by King's College London, also found lidocaine, alprazolam, diazepam and ketamine, a drug commonly known as Special K.
Environmental toxicologist Thomas Miller told NPR, however, that the "potential for any effect is likely to be low."
Scientists say they're not particularly surprised by the findings, but everyday consumers might be.
"Pharmaceuticals and personal care products and pesticides and these types of illicit drugs have been detected in surface waters all over the world, because when we use them, our waste isn't always treated properly, and so they come out in rivers and streams," Emma Rosi, an aquatic ecologist at the Cary Institute of Ecosystem Studies, told NPR.
Rosi has done studies similar to the one conducted by King's College in the past.
"What's very worrying is we don't know what the effects are, the ecological effects," she said.
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Megan was a freshman when she started attending Club with her friends. As our ministry leaders got to know Megan, we quickly found she had a lot of questions regarding Jesus. Megan comes from a split family where her mom and brother are atheist, and her dad and stepmom go to church. She has been "confused" about faith for a long time. At the end of her freshman year, Megan's family was going through a lot with a family member that was close to her. She sought me out to talk about the difficulties in her life. This led to some interesting conversations about Jesus, where she asked if I had a book about evidence of Jesus. I gave her the book, The Case For Christ, where she claimed to read about half of the book.
Once summer of her sophomore year hit, Megan got a job at the Aquatics Center in Columbia City where she met our Columbia City Campus Life Director, Jake Johnson. All summer long through conversations with Jake and attending Bible Study at the pool with her fellow pool staff, she began to understand a little more about Jesus. Then at the beginning of her junior year, Megan was all in for Campus Life because of what happened during the summer. Megan won a half off trip to the GoMad Conference at our kickoff event and went. While there, she heard the gospel, attended small groups, and made friends who would encourage her towards Jesus. The Monday after GoMad she posted on Instagram that she had decided to follow Jesus with everything she has.
I am so thankful for how God is working in Megan's life and look forward to how He is going to use her!


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Farmers And Herders Clash In Kwara
A clash between farmers and herders in Kwara state has led to at least three persons sustaining severe injuries.
A farmer, Alaparo Tunde and his two sons, Saheed Tunde and Taofeek Tunde, from Alaparo village reportedly confronted a herder, Haruna Adamu, who was caught grazing on their cassava farm with his cattle.
The confrontation between the farmers and the herder, it was further gathered resulted in hot argument and consequently the two parties engaged in bloody fight where cutlasses and other dangerous weapons were freely used.
Spokesman of the Nigeria Security and Civil Defence Corps in Kwara State, Babawale Zaid Afolabi disclosed that both the herder and two sons of the farmer were seriously injured in the incident which occurred at Alapa, Asa local government area of Kwara State on Saturday January 8.
He Said;
"It took the timely intervention of the operatives of the Agro Ranger Unit of the Nigeria Security and Civil Defence Corps, Kwara State Command to prevent what could have resulted in a full-scale bloody clash between farmers and herders in Alapa community in Asa local government area of Kwara State.
"The Agro Ranger Unit of the Corps got a distress call from Alapa community and promptly deployed officers to the scene of the incident.
"On Saturday 08/01/2022, based on a distress call from Alapa community in Asa local government area of the state, our Commandant, Makinde Iskil Ayinla directed the immediate deployment of the operatives of the Agro Ranger Unit to the location and thier timely arrival put the situation under control.
"Both the herder and the farmer's two sons were seriously injured and were later taken to nearby hospital where they are responding to treatment.
"In the meantime, security has been beefed up in the community while full scale investigations are ongoing to unravel the immediate and remote cause of the incident and how to prevent any act of reprisal."


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Category Archives: Family Law
On behalf of Peterson Stark Scott posted in Family Law on April 20, 2020.
In Canada, couples who are cohabiting are considered to be legally married after a certain amount of time has passed. In British Columbia, that amount of time is two years.
But some couples don't look favourably on the government deciding their relationship status. A Understanding marriage default laws in British Columbia
Tags: Family Law
There are no guarantees in life, and the same goes for marriage. No couple gets married with the notion that it will all come to a screeching halt one day. But some marriages do end in divorce.
One family law tool that has gained popularity in recent years is the marriage agreement ' also referred to as a prenuptial agreement. There are circumstances under which creating a marriage a...
Continue reading Should I say '"I do" to a marriage agreement?
Every person has the responsibility to ensure that children are kept safe from harm. There are family law rules in place in British Columbia that speak to the best interests of children. So, what should you do if you suspect a child in your family is being abused ' either physically, emotionally or sexually?
First, it' important to understand the indicators of potential abuse. Children...
Continue reading What to do if you suspect a child is being abused
Family law: Things to think about before a divorce settlement
On behalf of Peterson Stark Scott posted in Family Law on March 3, 2020.
Once a couple has made the decision to end their marriage, they may want everything to be settled as quickly as possible. There are rules under family law in British Columbia that must be followed, however, rushing into a settlement without thought of the future may be a mistake. Many people focus on the present rather than thinking about what kinds of lives they want in the future, so takin...
Continue reading Family law: Things to think about before a divorce settlement
Keep 3 things in mind during family law mediation
On behalf of Peterson Stark Scott posted in Family Law on February 27, 2020.
When British Columbia parents decide to part ways, emotions often run high. Feelings of resentment, anger and sadness often interfere with fruitful negotiations. If they keep three things in mind, however, it may be possible to put those feelings aside in order to receive the maximum benefits possible from family law mediation.
First, it helps to put the children's needs first. Wou...
Continue reading Keep 3 things in mind during family law mediation
Family law: Researcher says not enough done to end child marriage
The law states that doing what is in the best interests of children is imperative. There are rules in family law that safeguard children, but some believe that Canada is falling short when it comes to ending child marriage despite the fact that there are laws in place that protect children in British Columbia and the rest of the country from such situations. In fact, some experts say th...
Continue reading Family law: Researcher says not enough done to end child marriage
Family law: Appeal court says teen can continue hormone therapy
On behalf of Peterson Stark Scott posted in Family Law on February 5, 2020.
A teen can proceed with hormone therapy to transition from female to male, the B.C. Court of Appeal recently ruled. The British Columbia panel of three judges ruled that the teen, who identifies as male but who was born female, doesn't need further consent from his parents in order to proceed with treatment. Family law in the province says that a mature minor can consent to medical treatment...
Continue reading Family law: Appeal court says teen can continue hormone therapy
Family law: What is the right of first refusal?
On behalf of Peterson Stark Scott posted in Family Law on January 16, 2020.
When it comes to child custody situations, some people may not be familiar with the term, right of first refusal. Family law in British Columbia spells out the rules when it comes to issues regarding children. If one parent can't care for a child for a specific time, he or she may choose to use the services of a babysitter, rather than call on the other parent. Right of first refusal means t...
Continue reading Family law: What is the right of first refusal?
Family law: Salmonella from exotic pets could affect children
On behalf of Peterson Stark Scott posted in Family Law on December 26, 2019.
Studies have shown that it's important for children to have pets. British Columbia family law stipulates that the best interests of children always be at the forefront of any decisions made concerning them, but when unconventional pets can cause children to become sick, is that really keeping in line with that rule? The country's public health agency is asking the owners of exotic pets to pr...
Continue reading Family law: Salmonella from exotic pets could affect children
Family law: Getting on the same page regarding parenting style
On behalf of Peterson Stark Scott posted in Family Law on December 5, 2019.
It's never easy when divorced parents -- or any parents, for that matter -- have different parenting styles. Raising children can be much less daunting when two people are on the same page on how to do so regarding things like punishment, education, health care, values, religion and the like. Luckily, British Columbia parents are guided by family law when it comes to doing what is in the bes...
Continue reading Family law: Getting on the same page regarding parenting style


Learners competent at this level will be able to deal with learning materials, to access and use useful resources, to seek clarification and help when necessary, and apply a range of learning strategies. They do this with an understanding of the features and processes of the workplace and occupations to which their learning programme refer.
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Find and use available learning resources.
Resource centres, dictionaries, general texts, internet, other learners, videos.
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Signed/spoken input is listened to/viewed for detail.
Occupational learning materials are organized for efficient use.
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Information gathering steps are planned and sequenced appropriately.
Information gathering techniques are applied.
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Scope of information gathered is appropriate for given context and purpose.
Conclusions are presented in the appropriate format.
Active participation happens in group learning situations.
Turn taking, rotation of roles: conducting, chairing, recording, and reporting.
Teamwork results in meaningful products or outcomes.
Environmental features, technological resources, communication resources, communication strategies, and multilingual needs in relation to client or colleague interaction.
Organisation type: Government, parastatal, heavy/light industry, large organisation, small business.
Learners are unlikely to achieve all the specific outcomes to the standards described in the assessment criteria without knowledge of the listed embedded knowledge. This means that for the most part, the possession or lack of the knowledge can be directly inferred from the quality of the learner's performance. Where direct assessment of knowledge is required, assessment criteria have been included in the body of the unit standard. The following embedded knowledge should be taken into consideration: the ability to interpret maps, take notes, the ability to read/view texts, appropriate communication skills and the location of learning resources.
Collect, analyse, organise and critically evaluate information: through application of information processing skills in study.
This unit standard replaces unit standard 8967, "Use language and communication in occupational learning programmes", Level 2, 5 credits.
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Star Wars Jedi: Fallen Order is a spectacular production of the action that unfolds, was in the star Wars universe immediately after the events shown in the third episode of the series. For the preparation of the name is responsible Studio Respawn Entertainment (Apex Legends, titanfall series) and the company Electronic Arts. The name is the third big project associated with the George Lucas brand, which originated after EA acquired the rights to exclusive production of games with Star Wars in the title.
The story is presented in Star wars Jedi: Fallen Order, set shortly after the events shown in the third episode of the star Saga. Players take on the role of young Kala Kestis, a former Padawan who must hide his past from the soldiers of the galactic Empire, effectively executing the order of Emperor Palpatine 66, ordering the killing of all Jedi knights.
Trying not to pay attention to himself, Kal travels to the outer borders, to the planet Brakka, where he finds work in the thieves Guild, engaged in the dismantling of the Republic ships used during The clone wars. Soon, however, he should again save himself from escaping, when his trail enters the Imperial inquisitors hunting scattered throughout the galaxy of the Jedi. However, on his way, he will meet unexpected allies, including a new mentor named Cere, as well as a faithful BD-1 droid.
Star Wars Jedi: Fallen Order is an adventure game in which to play we see from a third person perspective. The gameplay model combines many elements known from other productions of the genre. During the game we use, in particular, a complex combat system using a lightsaber. This characteristic of the universe weapon changes and develops with the hero. During battles, players can also create their own combinations of attacks, as well as use various Jedi abilities. However, it is not always reasonable to draw attention to yourself; sometimes the best solution is to use silent methods to eliminate opponents or avoid a collision at all. Elements of the platform also play an important role. Thanks to the Power, for example, we can run on the walls, make incredibly high jumps.


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You have been in WMOC events in 2004 and in 2006. What memories do you keep from Italy and Austria? Do you still remember your races, atmosphere, terrains and landscapes?
I remember all them. We enjoyed very friendly atmosphere, wonderful terrains and landscapes. The organization was perfect and itineraries interesting.
Last year in Finland, in a Scandinavian terrain, you also reached B Final. Didn't you feel particular difficulties on that terrain? What are your main remembrances from Kuusamo?
It was also well organized. I enjoyed also meeting my old friends from Russia. Even mutual rains did not spoil the elevated mood.
Besides Italy, Austria and Finland, have you been to other WMOC events?
I participated in Euregio 2004 (Austria and Italy) and in 2005 in Fin-5 and O-Ringen. We enjoyed very impressive mountain landscapes traveling by car from Milano to Telfs and after to Trento in 2004. In 2005 we traveled by bus. We used ferry on the way to Sweden and besides it we visited Göteborg, Kopenhagen and other interesting places. O-events abroad always allow us to make sightseeing.
Which event was the best ever for you, concerning organization, terrain, courses, etc.?
I can't select any. I always was satisfied all but my results. Unfortunately I make errors and I can never be satisfied by my results.
Where were you born and where do you live?
I was born in Ural (Russia) and now I live in Israel in beautiful city Karmiel.
How did you discover orienteering and for how long have you practiced it? Do you remember your first races?
I made hiking and we practiced competitions of walking in given direction with compass. In 1961 the first competitions with map began in our region and shortly thereafter I became the member of our region team and began to participate in high-level O-events.
Have you practiced other sports? Which highlights can you indicate in your career?
I make cycling and swimming but without high achievements.
What was (is) your job? How can you coordinate work and sport? What kind of training do you usually do?
I am retired. The main training is running and cycling.
Can you tell us a little bit about orienteering in Israel?
The first O-event in Israel was held on 12.3.66 with 30 participants. In 1973 our Federation became the IOF member. Now we have about 70 competitions per year with maximal number of participants as big as 500. There are 13 O-clubs with about 1000 members. All competitions are organized by clubs at weekends, so we can run only 2 times a week. In summer there are no competitions because of hot weather. Israel teams participate in WOC, JWOC, WMOC and MTB O-championships.
What is the main orienteering event every year in Israel?
Can you give us a good reason to go to Israel for an orienteering event?
There is not one reason to visit Israel. First you can participate in foot O-events in winter and enjoy sunny weather and nice friendly atmosphere. Second, Israel has a highest concentration of points of interest in the world and you can in a short time make a wonderful trip visiting the unique places as Dead Sea, Jerusalem and many others. And so on, and so on.
What is the level of competition in the class where you usually compete in Israel?
In my group M70 there are three equal competitors, so you never know who win next time. Besides it we run the same course as M55, M60, M65, D40 and older and D21C. We look at younger participants results also and frequently we are better than many young participants.
Other people are coming from Israel to the WMOC 2008, at least, Enrique Zezynski, Doron Kissinger, Ivan Glaser, Menachem Minsky, Rafi Heiman, Yona Heima and Yonatan Dviv. Do you know all of them? Can you specify the skills of any of them?
Sure I know them. They are in other age categories but I think that we all have a similar level.
Why did you register for the WMOC 2008? What do you expect from this Portuguese event?
I like the atmosphere of WMOC, I enjoy meeting my old friends (as well as new ones), and I hope to enter at last to final A. I never was in Portugal and I hope to enjoy its beauty.
Do you want to add something about any topic, which I may have not asked you about?
You are welcome to Israel. And I wish to each WMOC 2008 participant to achieve his own goal.


After high school, Lauren King, plans on going to Danville Community College for two years then later transferring to a four year college.
She grew up in Chatham and has attended Chatham schools since elementary school.
"My advice for other students is to have common sense," she said.


The national Tea Party is holding a nationwide protest against Amnesty, this April 15. Please visit their website and you can see if there is a local event near you. If not, consider becoming an organizer in your city.
Curious. Since these are being run through ALIPAC, would an organizer have to toe ALIPAC's party line on various patriots that are out of favor with William Gheen?
I would be interested in getting something going for the Federal building. I am just not sure I want to carry a bunch of ALIPAC luggage too.
I think, therefore I love the Dodgers!
Just ignore the fact that Gheen has piggybacked on with the Tea Party people and if you can attend, support any gathering that fights illegal aliens. We all use any opportunity to gather like minded people. It seems that the only time so many will get out and do any activism is when it hits their pocket book. Everything else, the greater population expect 'others' to take up the cause and fight their battles. The illegals don't seem to have a problem with getting out and protesting, but they're much better funded.
I've been researching some of the Nonprofits along with where they're getting their money and what they're doing with it. Please take the time to review what I've come up with and posted. Until we know our enemy and where they're getting their resources we don't know who and what to address. I'd like to expose the root of our problem and take our activism directly to who is supporting it, just like ACORN was exposed. I hope the rest of you will support me in that.
Do you mean the Federal Building on Wilshire Bl. or the one in Downtown Los Angeles?
The Westside Republicans usually get something going at the one on Wilshire Bl. Let's hope they do a Tea Party.
I got the impression you were against the Republicans taking over the Tea Party movement.
Yes, there are the real Republicans and then there are the Schwarzeneggers, McCains, Bushes and Whitmans.
Jeff Sessions and Tom McClintock. That is what Republicans used to be and still are, just in more limited numbers nowadays.
The first illegal immigration/TEA Party gig orchestrated by ALIPAC was fun! I attended the Pasadena event (as did Jean, Glory, Frank, Papoose, LAPhil, etc.). Apparently, they're going to be held on the 15th and the 17th of next month. I want to attend at least two this time.
Last edited by DerailAmnesty.com; 03-23-2010 at 06:05 PM.
I think the Westwood Federal building would get the most bang for the buck.
I saw a link for one on Facebook, but they don't have a location or time yet, and the best part is that she who will not be named won't be there.
You are a true Patriot Jean. I will support you in almost any endeavor you would undertake.
This event has no signs or any money that is with ALIPAC. I am organizing this simply for the fight. I, and others, simply bring our own signs to protest amnesty. Please consider to come on up and be with fellow protests. Some of you know me from previous "old" SOS protests. I simply am organizing a local event because no one else will. Thanks for considering attending.


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Booker Introduces Legislation to Improve Access to Health Care for Medicare and Medicaid Beneficiaries
The Equality in Medicare and Medicaid Treatment Act would require the Center for Medicare and Medicaid Innovation (CMMI) to address disparities in health care access and outcomes
WASHINGTON, D.C. - U.S. Senator Cory Booker (D-NJ) today introduced legislation that would require the Center for Medicare and Medicaid Innovation (CMMI) to address disparities in health care access and outcomes when developing new payment and delivery models for care provided to patients, including Medicaid, Medicare and Children's Health Insurance Program (CHIP) beneficiaries. Under the Equality in Medicare and Medicaid Treatment Act, CMMI would be required to consult with experts on health disparities, such as the Office of Minority Health of the Centers for Medicare & Medicaid Services, the Federal Office of Rural Health Policy, and the Office on Women's Health, on any new payment models under development. In 2019, Congressman John Lewis introduced the bill in the House of Representatives.
The Center for Medicare and Medicaid Innovation (CMMI) was created under the Affordable Care Act to develop and test new health care payment models that reduce health care costs while also maintaining or improving quality of care. Since its enactment, CMMI has created and implemented 37 different payment models with the most well-known three being bundled payments, accountable care organizations, and patient-centered medical homes. Some of the models CMMI has implemented so far include models to improve diabetes care and facilitate home-based primary care.
However, under current law, CMMI is not specifically required to consider and address health disparities and social determinants of health, such as a patient's environment, education, and economic status, when implementing and testing new payment models. These factors primarily impact the health outcomes of rural, low-income, and communities of color and not addressing these issues can lead to larger health disparities and inequities among these communities.
"At a time when the disturbing inequities in access to health care and health outcomes have been exacerbated by this public health crisis, we need to be using every tool we have to improve the quality of and access to care, especially for the marginalized," said Senator Booker. "We know that how we pay for health care can directly impact the health outcomes we achieve, and the Equality in Medicare and Medicaid Treatment Act will seek to ensure that as we develop new ways to deliver and pay for health care, we are not exacerbating existing inequities but devoting attention and resources to closing them, and improving health outcomes for everyone."
The Equality in Medicare and Medicaid Treatment Act would also require CMMI to consider health care delivery innovations for individuals with behavioral health conditions, pregnant people, and people who are enrolled in both Medicaid and Medicare (dual eligible). Should the Secretary of HHS wish to expand a payment model tested by the CMMI, the bill would require that the Office of Minority Health at CMS certify that such expansion would not reduce access to care or increase disparities for beneficiaries who are low-income, live in a rural area, or are people of color.
Throughout his time in Congress, Booker has championed legislation to improve health outcomes and reduce health inequities, including the REDUCE Act, which he most recently introduced with Congressman Bill Pascrell, Jr. (D-NJ) in 2019. The legislation is aimed at reducing disparities in health care among marginalized groups.
The full text of the Equality in Medicare and Medicaid Treatment Act can be downloaded here.


Sookie & Finn: Our Day DVD is a fantastic new tool to boost your toddler's speech and language development. Our DVD has been proven to work in helping children with expressive and receptive language development and vocabulary acquisition.
Sookie & Finn: Our Day DVD has recently been awarded the PAL Award for Best DVD to Build Language.
The DVD is being used effectively by speech therapists with young children exhibiting speech delay both during and outside therapy time. Parents can use the DVD at home to supplement therapy or just as a little extra 'nudge' for the stubborn late talker.
We introduce 80 of the most frequently used English words, set in daily routines familiar to young children.
Six great nursery songs built into the story keep the little ones entertained and engaged.


When you have just bought a new boat, you will be eager to go test it in the waters. You have to ensure that you carry along some important boat accessories, when you want to go boating. You will not have to get scared when you are going bating with these accessories carried along. When you do to know the accessories that you need to carry along, then it is necessary that you continue to read this resourceful article. For that reason, you will need to consider the accessories that are highlighted here on this website, and learn more about them.
It is important that you carry along a motion sickness band when you want to go boating. Not getting sick when on the waters will take some argue that there is no reason to carry along the motion sickness bands. Even when you do not get sick on the water, there are some instances that you can just fall a victim. It is however important that you are ever prepared for any results. The boat ride will not be enjoyable when you fall motion sick, and you did not carry the motion sickness bands.
When going boating, you will also want to include the life vest. It is not recommended that you hit the water when you are not in the safety precautions. You will make sure that you carry enough life-saving jackets for the people that board the boat. You do not know the time that the worse can happen, therefore it is important that you include it in your package list.
when you go for boating, you will make sure that you carry the first aid kit as well. Accidents can happen and you will need to carry a first aid kit when you go boat riding. When you carry the first aid kit, you will need to include the cut-resistant gloves as well. Also, you will ensure that the first aid kit contain the antibiotics, bandages, and the ointments, that are the basics. It should also be placed in an open place that is easily accessible in case of an accident.
The last accessory that you will include will be the inflatable fenders. Docking the boat can at the time be a daunting task. In case it is your first boating, then you will find it even a more daunting task. When you are new to boating, you will find that most of the time you will be knocking the pillars. Even when you are an experienced boater, you will need to include these accessories I case the storm hits your boat too hard.


Dr. Linda Jando has been the owner and a family physician at Aquarius Medical Clinic in Vancouver, BC since 2002. She has grown the clinic to a busy practice with many doctors and staff in various areas of specialization.
Dr. Jando teaches at the UBC Faculty of Medicine and acts as "Clinical Assistant Professor" one of the university's Clinician Advisors at Lion's Gate Hospital. She is a surgical assistant at Lion's Gate Hospital, and Delbrook Surgical Centre, primarily in the area of orthopaedic trauma. She works as a medical consultant for TV shows, performing research and providing advice to producers, writers, directors and other departments.
Previously, Dr. Jando was an associate full service family physician at Broadway and Burrard Medical Clinic in Vancouver, where she supervised UBC undergraduate medical students. She also supervised medical students and residents and led evening contraception clinics at Options for Sexual Health in Vancouver.
Dr. Jando graduated from the Faculty of Medicine at UBC in 1998, then completed a Family Practice Residency there. She began practicing as a family doctor in Vancouver in 2000, completing a Women's Health fellowship in 2002 as she wanted to have enhanced skills in non-maternity related issues such as IUD insertion, endometrial biopsies, contraception options and menopause management.
Dr. Jando works closely with her husband, Dr. Victor Jando, in the operating room and with trauma patients. They have three children and love to spend family time playing sports, hiking, swimming, skiing, and going on vacations.
( Dr. Linda Jando, Family Doctor, Vancouver, BC ) is in good standing with the College of Physicians and Surgeons.
The speaker in the video may have no association with ( Dr. Linda Jando, Family Doctor, Vancouver, BC ). ( Dr. Linda Jando, Family Doctor ), may talk about some of the conditions and some of the treatment options shown in the videos on HealthChoicesFirst. Always talk with your health care practitioner about the information you learnt from the videos in regards to treatments and procedures the healthcare practitioner could perform and if they would be appropriate for you. Remember good information is the corner stone to understanding your condition or disease.
Please contact ( Dr. Linda Jando, Family Doctor, Vancouver, BC ) to enquire if this health care provider is accepting new patients.
La Dre Linda Jando, B. Sc., MD, CCMF, médecin de famille, discute du diagnostic de l'herpès et des options de traitement.
Dr. Linda Jando, BSc., MD, CCFP, Family Physician, discusses the diagnosis of herpes and treatment options .
Dr. Linda Jando, BSc., MD, CCFP, Family Physician, discusses HPV and how it is contracted.
Dr. Linda Jando, BSc., MD, CCFP, Family Physician, discusses Chlamydia diagnosis and treatment.
Dr. Linda Jando, Family Doctor, Vancouver, BC is a very good family physical who has been my family doctor for three years.
Recently saw Dr Linda Jando for my constant headaches and found her to be very well informed and up to date on the latest information. I would recommend Dr Jando to anyone looking for a good family doctor.


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Dagmara Komorowicz (born 1 May 1979) is a Polish swimmer. She competed in the women's 100 metre backstroke at the 1996 Summer Olympics.

References

External links

1979 births
Living people
Olympic swimmers of Poland
Swimmers at the 1996 Summer Olympics
Sportspeople from Lublin
Polish female backstroke swimmers
20th-century Polish women


It's that time of year again when everyone starts getting ideas for the holidays, decorating, which family to spend time with for which holiday, and… Oh! Christmas cards! What are we gonna do this year for Christmas cards?!!! Yeah, I just thought that yesterday!
Contact me if you've been thinking about your Christmas cards, too, and want to get in a quick family photo session!


Data released by the U.S. Energy Information Administration March 20 indicates weekly U.S. ending stocks of fuel ethanol set a new record the week ending March 15, reaching 24.412 million barrels.
Stocks were up approximately 681,000 barrels when compared to the prior week. When compared to the same week of 2018, stocks were up approximately 654,000 barrels. The record-setting stocks reached for the week of March 15 mark only fifth time stocks have risen above the 24 million barrel mark, according to EIA data. Ethanol stocks reached 24.261 million barrels earlier this year during the week ending March 1. Stocks reached 24.021 million barrels the week ending Oct. 5, 2018, and increased to 24.130 million barrels the following week, which ended Oct. 12, 0218. Ethanol stocks first crossed the 24 million barrel mark the week ending March 9, 2018, when stocks reached 24.281 million barrels.
On a regional basis, stocks for the week ending March 15 reached 7.565 million barrels in PADD 1 (East Coast), 9.129 million barrels in PADD 2 (Midwest), 4.864 million barrels in PADD 3 (Gulf Coast), 330,000 in PADD 4 (Rocky Mountains), and 2.524 million barrels in PADD 5 (West Coast, Alaska and Hawaii).
Ethanol production averaged 1.004 million barrels per day the week ending March 15, down slightly form 1.005 million barrels per day the previous week, and down significantly from 1.049 million barrels per day reported for the same week of last year.


Over 40 matai title holders were bestowed at the Malae Vaitoga in Puipa'a yesterday.
The two highest matai titles were Pagamalie (orator) – which were given to five people – while four were the recipients of the Tagaloa title. The other titles that were bestowed at the same ceremony included: Vaitoga, Lasei, Leao, Puniloa, Timuiaipaepaetele, Paepaeloa, Matuaileala, Tapaleao, and Faaofonuu.
The ceremony was blessed by Reverend Ioane Tolai of the Methodist Church early yesterday morning.
One of the newly bestowed matai title holders, Tagaloa Paepaetele Alaimaseiga, expressed his great joy over the occasion.
"This title comes with great responsibility not only to my family but also our church, village and communities," Tagaloa said.
Tagaloa added that it is important to serve with honesty, righteousness and with God's guidance so that everything will end well and run smoothly.


AssuredPartners, Inc. and its Employee Benefits Committee for Affordable Care Act Compliance has formed a new partnership with national law firms BakerHostetler and Proskauer to provide Affordable Care Act compliance counsel to clients of AssuredPartners' platform companies. BakerHostetler and Proskauer have a regional presence in the Midwest and Northeast, respectively, and cover much of the AssuredPartners geographic footprint.
Through this partnership, the law firms will operate as an extension of AssuredPartners, offering compliance advice for AssuredPartners' agent consultants and clientele.
AssuredPartners has entered into these partnerships on behalf of their platform companies. This deal solidifies the partnership on behalf of the following entities: Neace Lukens, SKCG, Jamison Insurance & Grosvenor Brokers, Dawson Companies, ISI, Crawford Insurance, Webb Insurance, Schifman, Remley & Associates, Inc., Alliance Plus and Tobias.
BakerHostetler's five primary practice groups are business, employment, intellectual property, litigation and tax.
Proskauer is a global law firm with offices in Beijing, Boca Raton, Boston, Chicago, Hong Kong, London, Los Angeles, New Orleans, New York, Newark, Paris, São Paulo and Washington, DC. The firm focuses on navigating the Affordable Care Act through its interdisciplinary health care reform task force, which comprises lawyers from the firm's employee benefits, health care, labor and tax practices.


"The Genesee County History Department is an educational institution dedicated to the collection, preservation, research, interpretation, and promotion of archival materials relating to the County."
The purpose of this department is to provide protection and a systematic control for the records created by our local government. Records Management is an administrative service that ensures the legal disposition of obsolete records, identifies, preserves, and encourages the use of archival records, provides efficient records storage, and makes records available when needed.
The goal of this department is to ensure that records are properly administered and available to local government officials, citizens, and researchers.


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Home » Posts tagged with » Kristina Keneally
NSW Premier Promotes Social Bonds
Some $25 million will be set aside for government social bonds in a pilot project for non-governmental early intervention programmes if the government is re-elected, say NSW Premier Kristina Keneally.…
March 6, 2011Comments Off on NSW Premier Promotes Social BondsRead More
Australia's Longest Bridge in New South Wales
Australia's longest bridge will soon be built in Kempsey, New South Wales' mid north coast town. According to recent statements, Abigroup will both build and design the above mentioned bridge…
February 17, 2011Comments Off on Australia's Longest Bridge in New South WalesRead More
O'Farrel Continues to Oppose National Hospital Reforms
Barry O'Farrel, the leader of the New South Wales opposition, said that he would not be "locked into" health reforms. The statement comes in a crucial time as the state…
February 9, 2011Comments Off on O'Farrel Continues to Oppose National Hospital ReformsRead More
$194M to Upgrade Campbelltown Hospital
New South Wales' Premier Kristina Keneally said that $194.3m will help Campbelltown Hospital's upgrade, which is necessary as the population in Sydney's southwest has increased. The funding was announced today…
February 3, 2011Comments Off on $194M to Upgrade Campbelltown HospitalRead More


text:
package org.apache.cassandra.db.compaction;

import java.util.Collection;

import org.apache.cassandra.db.ColumnFamilyStore;
import org.apache.cassandra.io.sstable.SSTableReader;
import org.apache.cassandra.io.sstable.SSTableWriter;

public class LeveledCompactionTask extends CompactionTask
{
    private final int level;
    private final int sstableSizeInMB;

    public LeveledCompactionTask(ColumnFamilyStore cfs, Collection<SSTableReader> sstables, int level, final int gcBefore, int sstableSizeInMB)
    {
        super(cfs, sstables, gcBefore);
        this.level = level;
        this.sstableSizeInMB = sstableSizeInMB;
    }

    @Override
    protected boolean newSSTableSegmentThresholdReached(SSTableWriter writer)
    {
        return writer.getOnDiskFilePointer() > sstableSizeInMB * 1024L * 1024L;
    }

    @Override
    protected boolean partialCompactionsAcceptable()
    {
        return false;
    }

    protected int getLevel()
    {
        return level;
    }
}

redpajama_set_name: RedPajamaGithub


text:
By VF
VF x SUPERRARE – CREDIT TO THE EDIT – artist profile : FERNANDO LIVSCHITZ
Uplifting, dream-like and fun, Argentine film-maker Fernando Livschitz works playfully through Magic Realism. His stories unfold organically showing the extraordinary as something ordinary and common. Going deeper into reality through the wonder that is in it by creating a charming and mind-boggling mood.
"I'm a film director, creative and visual artist based in Buenos Aires, Argentina. With a unique sense of style and approach I show my perspective of the world. I try to put a smile on people's faces. I believe it's always possible to show the life and ideas in an alternative way"
Directing all around the world he won the Young Directors Award at the Cannes Lions, and has worked for brands such as Mondelez, Audi, Renault, Nissan, Coca Cola and he created the opening credits for CBS's The Late Show with Stephen Colbert.
His projects go viral rapidly and have been seen by more than 100 million people. He works from film to photography, branded content to music videos and visual arts to digital content.
Tetris – Click here to view on SuperRare
Swimmers – Click here to view on SuperRare
Credit to the Edit – Fernando Livschitz Q&A
Have you always been both creative and technically minded or did one follow the other?
I think they were always together. My creativity was always tied to technical possibilities and vice versa.
How did you get into the world of creative video production?
I come from a family from the world of cinema and advertising. From a very young age I worked on this.
How would you best describe your signature style?
I like to show the everyday but in an alternative way, that viewers need to stop for a second and watch again, think and have a new vision of the same image.
Can you pinpoint a moment in your career that was a pivotal turning point?
Yes, when I did the film "Buenos Aires Inception Park". That project went viral and opened a lot of new doors.
What inspires you in your personal work?
In short, life itself and how ridiculous it is sometimes.
What are some of your ambitions as a creative?
Always do something different and try not to copy myself.
Is there anyone that you'd particularly like to collaborate with?
Yes, many. Romain Laurent, Leandro Erlich, Nowness, Apple…
What are your thoughts about the NFT space as it stands. Specifically in relation to your style of work and how you see it evolving.
I am in the process of understanding what it is about. But from what they tell me, my work and my style are going very well with the NFT space. It is a new space for artists to show their work and that is always good.
Instagram : https://www.instagram.com/ferliv
Twitter : https://twitter.com/fer_liv
Web : https://www.bsfilms.me
SuperRare : https://superrare.co/ferliv
Art Exhibition, Artist Focus, film, Interviews, NFT, NFTs, Video Art
VF x SUPERRARE – CREDIT TO THE EDIT – artist profile : FRANCOIS VOGEL
VF x SUPERRARE – CREDIT TO THE EDIT – artist profile : Jules Langeard
VF x SUPERRARE – CREDIT TO THE EDIT – artist profile : Joe Pease
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Visual Fodder exists to entertain and inspire the creative community by showcasing the most innovative and thought-provoking work from creators across the globe.
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VF x Deutsche Telekom | Pt 2
Artist Focus
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