The Common Assessment Framework (CAF or Early Help) is a standardised, shared assessment and planning framework used to help early identification of a child or young person's additional needs.
It's also used to promote co-ordinated service provision to meet these needs and is a key element of the Every Child Matters: Change for Children Programme.
This course will help you understand the background and principles of the CAF assessment. The course also provides useful advice and guidance to practitioners and agencies involved in CAF safeguarding and the assessment and reviews process.
The short, easily digestible course contains useful links, additional resource materials, useful links and a refresher guide as well as certification with CPD hours and learning objectives. The demo option allows you to see whether it's suitable before you sign up.
This course is intended for all children's workforce practitioners, that is anyone who works with children, young people and their families.
Although this course does form part of an induction programme for new starters, it is also intended for anyone who needs to improve their knowledge and continue their professional development.
It's a great grounding for anyone who wants to know more about CAF, multi agency working and gathering information effectively regarding assessments.
I have done other online courses before, this one was the best.
This was an excellent opportunity to understand CAF and how this is to achieve better outcomes.
Overall I found this course interesting and comprehensive.
Suitable for all staff working with children and families. Clarifies how all agencies can contribute to successful support to families.
This served my purposes well. I have undertaken the full CAF course and this was ideal as a refresher. Thank you.
I do have a clearer understanding of the CAF process now.
I enjoyed doing the course and answering questions as it went along thus making sure it was understood.
Enjoyable and informative short course, easy to navigate and something I will return to again and again.
The course has given me the information and guidance i required in order to know when to undertake a CAF.
This was very engaging and I learnt a lot about CAF. It is very easy with simple instructions. Thank you.


Hulu released a documentary on the disastrous Fyre Festival on Monday, days before Netflix is set to release its own.
But data from Google Trends shows that Netflix has been leading Hulu in search interest on the subject.
The streaming war is heating up, with Netflix and Hulu releasing competing documentaries on the exact same subject this week.
Hulu surprise dropped a Fyre Festival documentary on Monday called "Fyre Fraud," days before Netflix is set to release "Fyre," its own documentary on the disastrous music festival that drops on January 18.
But data shows that Netflix has been dominating search queries on the subject.


When Naseer and Shahab first released Za Sta Pashan Na Yam, the song took Pakistan by storm. Although several musicians had released well-received versions of pop and rock songs sung in Pushto, this was perhaps the first to crossover into the mainstream. The remarkably catchy chorus, which translates into "I am not like you", is a rejoinder to those obsessed with material gains and advantages. The lyrics continuously re-affirm the ability to love as being the one thing that what sets us apart from those chasing shallow pursuits. The song's original had a stadium-rock feel to them, and the Coke Studio version seeks to amplify that with the inclusion of legendary guitarist Faraz Anwar. The veteran musician specifically requested the producers to let him join in on the track, which had the space and the mood that allowed him to launch into one of his trademark performances. The rest of the houseband has also structured its compositions to allow the entire song to be an even grander version of its own self while retaining the distinctive identity which had led to its original success.


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redpajama_set_name: RedPajamaGithub


This is a placeholder page for Scelena Harris, which means this person is not currently on this site. We do suggest using the tools below to find Scelena Harris.
You are visiting the placeholder page for Scelena Harris. This page is here because someone used our placeholder utility to look for Scelena Harris. We created this page automatically in hopes Scelena Harris would find it. If you are not Scelena Harris, but are an alumni of Johnson High School Huntsville, AL, register on this site for free now.


With the final season of the TV series New Girl wrapping up, Max Greenfield has decided to let women hear his thoughts in the gender swapped film, What Men Want. The Paramount film follows the same format as the 2000 Nancy Meyers film that starred Mel Gibson, What Women Want.
This time, it is the women that can hear the men's thoughts. Taraji P. Henson plays a sports agent in a male driven field, who feels boxed in by her colleagues. Once she gains the power to hear men's thoughts, she is suddenly able to shift things to her advantages as she attempts to sign the next superstar for the NBA.
Greenfield is set to play one of the sports agents whose thoughts Henson is able to hear. In addition to starring in the series, New Girl, Greenfield recently starred in Liongate's The Glass Castle as well as Netflix's A Futile and Stupid Gesture. He can also bee seen in both American Crime Story and American Horror Story.
What Men Want is set to debut in theaters January 11, 2019 under Brian Robbins and Ali Bell through a new devision of Paramount that was launched last June.


Description: "Incredible" is the only way to describe this moth. Every color is represented on the wings and body of this spectacular insect. The bright coloration advertises their distastefulness. This advertisement is called aposematism and has been naturally selected for thousands of years. The plants the caterpillars feed on contain large amounts of distasteful alkaloids, these chemicals are stored by the moth for its own defense. Interestingly, this moth is often erroneously referred to as: "the most beautiful butterfly in the world".


Save time and effort by booking your London City Airport transfer with Airport Transfer Service! Our TFL-licensed chauffeurs operate 24 hours a day, 7 days a week.
With convenient 45-minute wait times, Airport Transfer Service makes it easy to travel from London to London City Airport-and do so in total class and comfort.
Schedule your London City Airport Transfer with a TFL-licensed chauffeur - call us today or get a fast online quote!
Although Airport Transfer Service provides passengers with a convenient 45-minute wait time, it's important to keep up-to-date on the latest arrivals and departures times.
For the latest details, view the latest London City Airport arrivals and departures information.
Note to passengers: London City Airport has a "silent airport policy". This means announcements are only made during emergency situations or adverse weather conditions. Announcements are never used to personally address passengers or call passengers to the boarding gate.


text:
Taking The Country's Side, Agriculture and Architecture
drawingmatter.org
Adam Caruso contributes a review of Sébastien Marot's 'Taking The Country's Side, Agriculture and Architecture' to Drawing Matter.
The book was formed from themes and ideas presented at the 2019 Lisbon Architecture Triennale. There Sébastien Marot gave a talk that discussed his work on the countryside, in relation to Rem Koolhaas's Guggenheim exhibition, 'Countryside, The Future'.
Caruso explores the way Marot has approached architecture and agriculture's existence in the Anthropocene; offering similaritites and differences to Koolhaas's approach. Gathering an understanding of the future Marot believes we should aim towards; one of permaculture, through incorporation, negotiation, infiltration, and secession.
Photo © Trienal de Lisboa
L'Architettura di Milano
Adam Caruso contributes a text on the Condominio XXI Aprile by Asnago Vender to L'Architettura di Milano. Published in November, the book describes and interprets 150 of Milan's significant post-war buildings.
A Conversation with Adam Caruso
Adam Caruso was interviewed for OASE Journal's edition on modernity. Emailing with the issue's editors, Tom Avermaete and Hans Teerds, he discusses the nuances of what it means to be 'modern' and how to engage with a cities architectural codes and conventions while adding to its definition of history.
Project: Office Building, Escher Wyss Platz
Project: Canterbury Cathedral Organ Loft
Project: Bremer Landesbank Headquarters
Gagosian Quarterly: Sigurd Lewerentz
The exhibition Sigurd Lewerentz: Architect of Death and Life opens in October at ArkDes, Stockholm. To mark the occasion Gagosian director Mark Francis spoke with Adam Caruso, Kieran Long, director of ArkDes, and Swedish arts critic Anna Nittve. They discussed the extent of the exhibition's research and design, as well as the enduring legacy of Lewerentz. The interview features in the Fall 2021 edition of Gagosian Magazine.
Studio International: Hospitalfield Arts
studiointernational.com
Peter St John was interviewed by Veronica Simpson about the practice's renovation work at Hospitalfield House in Arbroath. They discussed the recently completed Café and Fernery, alongside the future plans for the arts centre.
Design in Dialogue
ruby-press.com
An interview with Caruso St John on their work at Tate Britain features in Design in Dialogue. The publication is the second book in Ruby Press' series Chapters, it focuses on how design processes can be shaped through dialogue.
Against and for Method
Revisiting Architectural Design as Research
An interview with Adam Caruso features in a new gta Verlag publication, Against and For Method. Edited by Jan Silberberger, the volume tries to tackle the deficiencies in studio teaching and proposes possibilities for integrating research approaches into teaching and practice.
AV Proyectos
arquitecturaviva.com
A selection of Caruso St John's recent competition entries feature in Issue 103 of AV Proyectos. The issue includes prize-winning designs for the new AXA office building in central Zurich, the OLMA exhibition pavilion in St Gallen, and a pair of apartment buildings in Eggen, Lucerne.
Sigurd Lewerentz: Architect of Death and Life
arkdes.se
Published this month is Sigurd Lewerentz, Architect of Death and Life. The monograph covers both his built and unrealised designs; from retail spaces, churches, cemeteries and landscapes, to exhibition architecture, graphics, product design, furniture and interiors.
The comprehensive book coincides with ArkDes' exhibition of the same name. Caruso St John has designed the exhibition, which opens in October this year.
A+ Sessions
a-plus.be
A+ Sessions was launched last year to discover more about architects' approaches. Interviewing a range of international architects, A+ has shown the breadth of contemporary architectural thinking.
Adam Caruso answers a series of quick-fire questions, choosing between Robert Smithson or Gordon Matta Clark, painting or photography, and architecture or agriculture.
hochparterre-buecher.ch
Adam Caruso contributes an essay to monumental_. The 'monumental' in the 21st century is seen as a questionable characteristic. Its dubious reputation resulting in its demise, particularly with urban planning. Dortmund Positions' first book in a series of symposium texts, tackles this issue with writing from Adam Caruso, Heike Hanada, and Wilfried Kuehn, among others.
The New Gallery Walsall: Garman Ryan collection
Walsall, United Kingdom
The Guardian is currently exploring the collections of British institutions, highlighting important artworks. From the New Art Gallery in Walsall, Julie Brown the collection's curator, analyses and celebrates Sally Ryan's sculpture 'The Martinique'.
Project: New Art Gallery Walsall
Epics in the Everyday
Photography, Architecture, and the Problem of Realism
jesusvassallo.com
Jesús Vassallo discusses the work of Caruso St John in his recently published book.
Epics in the Everyday: Photography, Architecture, and the Problem of Realism, sets out to write an alternative history of contemporary architecture and documentary photography, through a series of case studies that include Caruso St John's collaborations with Thomas Demand.

redpajama_set_name: RedPajamaCommonCrawl


Lightweight, fast and stable, the unique new ultrasonic motor stages from PI are easy to control and integrate into industry and research applications.
August 17, 2017, Auburn, MA – Nanopositioning design and engineering global leader PI (Physik Instrumente) delivers a new ultra-compact XY scanner and positioner powered by small integrated direct-drive ultrasonic piezoceramic motors (a single axis version is also available). The patented drives provide smooth motion with high resolution and the self-locking motor principle is a significant advantage over magnetic drive technologies: once the motor reaches a target position, it acts like a ceramic brake and locks the platform into place, providing extreme long term stability at zero driving current and heat generation.
The U-723 joins PI's existing portfolio of compact linear stages. It provides more than 0.8" travel per axis (22x22mm), with a footprint of only 42x42mm (1.6x1.6"). Its low profile of 21mm (~0.8") and miniaturized design allows for easy integration into existing systems, especially when space is limited. In addition to high speed motion up to 200 mm/sec, the low inertia (direct drive, no rotating parts) allows for a very dynamic start-stop behavior with settling times in the millisecond range. Based on the ultrasonic principle with drive frequencies >100kHz - way beyond the human hearing range -, the motors are very quiet. Displacement is generated in continuous sub-nanometric increments, leading to extremely smooth motion with a wide dynamic range from 1µm/sec to 200mm/sec.
Incorporated optical linear encoders provide position feedback with 10 nanometers resolution. Higher resolution stages are also available from PI. Due to the low power requirement of the ultrasonic motor, the U-723 can be integrated into mobile measuring and medical devices. Vacuum compatible versions are also available.
To take advantage of the operating principle, providing superior dynamic performance with settling times in the millisecond range while maintaining high resolution and smooth operation, ultrasonic motors benefit from advanced control strategies, such as automatic switchover between several static and dynamic PID parameter sets and adaptive frequency tracking. PI offers a number of ultrasonic motion controllers (C-867 and C-877 product families) available in desktop, rack-mount, and OEM configurations. An ASIC chip containing the motion control algorithms is also available for OEM customers. A comprehensive software package is included: drivers and example programs for LabVIEW, dynamic libraries for Windows and Linux, MATLAB are available. Interfaces include TCP/IP, USB, RS-232 and analog.
Watch the U-723 in Action – scanning an array of optical diodes!


StripSafely welcomes Guest Blogger, Certified Diabetes Educator and Champion of People with Diabetes, Hope Warshaw. We support quality diabetes education – It is how patients learn to StripSafely.
As you well know taking on the role of advocate and activist for what we believe is right and just for people with diabetes is crucial. I've done my best to support a number of DOC advocacy projects over the last few years. Now, I'm asking you to assist me and the American Association of Diabetes Educators (AADE) to advocate for increasing patient access to diabetes educators and Diabetes Self-Management Training (DSMT).
Please join me in supporting and participating in AADE's Diabetes Education for All Twitter campaign. This legislation would require Medicare to recognize credentialed diabetes educators (which includes CDEs – certified diabetes educators, educators with the credential BC-ADM and diabetes educators licensed by their state) as Medicare providers of DSMT thereby increasing access to this critical benefit for the patients we serve.
Let's make this change happen! With better access to education I hope more people with diabetes can be successful in self-care. Please join me in talking and tweeting about ways to help people get quality diabetes education.
To make this easy for you, our friends at StripSafely have created this page to make sending a tweet easy.
On behalf of AADE and diabetes educators around the country, I thank you. Let's continue to work together to improve life and health outcomes for people with diabetes!
It's time we enforce support of self management of blood glucose. No medication can get someone to choose less carbohydrates when glucose levels take them above 180 mg/dl. The teat strips can help each person understand what works or doesn't & can prevent the costly and preventable causes of complications of diabetes. Monitoring can be their compass.


Check out our discount clearance clergy robes and items for sale. We guarantee you'll find the preacher robes you're looking for either online or in our stocked warehouse in Hamilton, New Jersey. We stock high quality clergy robes at a discount price. We offer a wide variety of styles and colors of clergy robes so no matter what you're looking for, we guarantee we have it for you.
Regardless of the robe you pick, we can customize it to fulfill your individual preferences. Our black and gold robes are one our top selling preacher robes for sale at a cheap $119.95. We're also offering a discount on our white clergy robe at the affordable price of $69.95.
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This dish of Keto Cauliflower Mac and Cheese makes a great entree option, and it also makes a fantastic side dish to accompany your choice of meats. This is a very quick and easy recipe to make, and if you feel like cutting some corners on the recipe to save time or be more convenient you can even use "Steam in the Bag" Cauliflower to make this recipe too if you like. We won't judge you if you don't feel like making it totally from scratch.
We also think that the Cheddar Cheese Sauce that we make in this Keto Cauliflower Mac and Cheese Recipe could go great mixed in with Broccoli or other steamed vegetables too (Did we hear some of your say Brussels Sprouts?).
When we make this for our kids we leave out the Bacon and the Jalapenos on their portion, because my son doesn't like Spicy foods. Then again, he thinks that Black Pepper is too hot sometimes too.
We would love to hear your suggestions or comments down below in the Comments section if you have some more creative ideas for us, or if you would like to share how you make your very own Keto Mac and Cheese too.
Heat up a Large Frying Pan over Medium High Heat and add in 6 strips of Uncured Bacon. Cook the Bacon while preparing some of your other ingredients.
Break up 1 Medium Head of Cauliflower and chop up just the florets at the top. Do not mince these too finely, because we do not want this to have the consistency of Cauliflower Rice. Instead we want it to be kind of chunky still, like the texture of Macaroni Shells.
Cover the Cauliflower with some water in a Microwave Safe Dish with a lid on it and cook on High for about 10 minutes to tenderize.
Shred 2 Cups of Cheddar Cheese, and De-seed and Dice your Jalapeno.
When the Bacon is fully cooked and crispy, remove it from the Large Frying Pan, but retain the Bacon drippings in the pan.
Add the Diced Jalapeno to the Frying Pan and stir quickly to try to coat it evenly in the rendered bacon drippings. Saute and stir for about 3 minutes, until tender and then remove from the pan and set aside.
In that same Large Frying Pan add in 1 Cup of Heavy Whipping Cream, and 4 Ounces of softened Cream Cheese. Stir together a couple minutes until well blended.
Sprinkle in about 1 Cup of the Shredded Cheddar Cheese, and stir until melted in.
Season the Cheese Sauce with 1 Teaspoon Dijon Mustard, 1 Teaspoon Tumeric, 1/2 Teaspoon Granulated Garlic, and Salt and Pepper to taste.
Add in the strained and cooked Cauliflower, half of the cooked bacon (diced up), and the Jalapeno. Stir to incorporate the sauce evenly with the ingredients.
Top with the remaining Shredded Cheddar Cheese and cover with a lid to simmer for about 5 minutes (or until the cheese on top has melted).
Remove from the heat and serve as an Entree or as a Side Dish with another meal.
I just made this and, OMG – so good. I wish I could post a picture so that everyone can see just how pretty my plate is. Thanks so much for the receipe.


Artist: Carrie Mae Rose wearableweapons.com Camera/Edit: Yuan Liu Sound: Psapp "Velvet Pony"
BRACELETS - made with Confiscated recycled TSA scissors with zip ties.
Exhibition - made with Confiscated recycled TSA scissors with zip ties.
Installation - made with Confiscated recycled TSA scissors with zip ties.
BRACELET - made with Confiscated recycled TSA scissors with zip ties.


I'll bet you would normally pass this recipe right on by! Chickpeas in a chocolate cake - gross! No way would my kids ever eat this, you say. Well, I'm going to prove you 100% wrong! This recipe is one of my favorite dump, blend and bake recipes. It really doesn't get any easier, and it's so simple that it lends itself to playing around with flavors. You can use honey or maple syrup as the sweetener, you can use different extracts, essential oils or spices to switch up the flavors a bit. Have fun and make it your own! I like to serve it with a dollop of whipped coconut cream or ice cream and fresh berries on top. Yum yum time! For more recipes like this one, visit the shop tab on my website and check out my Love Bites cookbook. It's full of healthy sweet treats!
Preheat the oven to 350 degrees F. Lightly grease 8x8 glass dish with coconut oil. Add all ingredients except pink Himalayan sea salt, into a food processor and blend until smooth (you will have some chocolate chip pieces, and that is fine). Pour into dish and sprinkle with salt, if you desire. Bake for 25 minutes. Allow cake to cool for 20 minutes before serving. Store in the fridge.
Optional: To experiment with flavors, feel free to add 2 drops of Orange or Peppermint Vitality essential oil or 1 drop of Cinnamon Bark Vitality essential oil to the honey or maple syrup before blending.


Most of the real estate projects in Thane have incorporated a living experience focusing on the well-being of its residents. As a part of this feature, it also focuses on the safety well-being of its residents. Plenty of real estate's properties have now taken strict measures, to ensure that its residents, are well protected and prepared to face any emergency situations, such as a building fire.
With the thriving dark clouds and drizzling showers looming ahead on the horizon, everyone is bracing for the onset of monsoon. As of the last few months, our water resources have been getting a lot of attention, due to its dire need for conservation. It comes as no surprise that water supply to most cities is of a huge concern now, wherein plenty of real estate institutes taking measures to ensure the preservation, if not; the reduction of water wastage.
Keeping this in mind, the city of Thane, owing to its good ideology of combining a living abode amongst a natural habitat, has developed a well-planned strategy to preserve its water resources, especially in the time of water crises as of now. Real estate projects like the Neelkanth Group has taken measures, to ensure that water preservation is an essential part of one's lifestyle. Inclusive of these measures, you can even use a few tricks to lessen your individual water footprints. Given below are a few simple hacks that can help you take measures to help prevent the water crises from recurring again.
The dry area of a home is the last place where anybody would want to spend much time. This dry area, popularly known as the laundry area, is the only place wherein one can hang their laundry to dry. However, after spending considerable time carrying heaps of freshly laundered clothes from the washing machine to this area, you definitely would not have the time to set up a traditional drying rack and take it down, anytime you are done with the laundry.
Nevertheless, there is no reason why you should go through this inconvenience every single time you need to do your laundry. Imagine converting your dry area, provided by the real estate companies in their residential projects into a versatile space, wherein you can save a lot of your energy and space too. You only need to consider the space of the dry area in the flats for sale in Thane, and how you can utilize it. The next step is to incorporate a few DIY tricks. With a few DIY tips given below, here are some options you can consider.
Living room décor trends closely resemble any fashion trend, which is in a constant flux. Today's trend could be yesterday's past, thus leaving you with an outdated room décor. However, real estate companies have recognized the rising trends of possible living room decors that will transform your stark room into a room of awe and envy amongst your guests. Here are a few décor trends you can incorporate into your living room for this year.
Your home is the one place where you will spend most of your time. Therefore, imparting the essence of positivity is a requirement, when you or your family are at home. Your home, especially your living room should impart the feel of serenity and comfort, against the stress and turmoil of the outside world. It should be the perfect haven that embraces, reflects, protects and inspires you.
The real estate company in Thane have understood this prerequisite and incorporated architectural designs that ensure a flow of positivity, reinforcing the harmony between people and their homes. However, you as a potential homeowner can take additional steps to improve this positivity. Before you purchase the flat for sale in Thane, you can consider these tips.
Bathrooms are one of the most occupied rooms in the house. To many it serves as a purpose wherein one can get ready for work. To others, it is the perfect haven to relax and unwind after a stressful day. Plenty of the real estate company in Thane has incorporated diverse architectural designs to suit this purpose while ensuring it satisfies your every need.
As compared to the other rooms in your home, your bathroom is the not only one of the smallest but also one that you would occupy several times a day. Although the real estate company in Thane has designed bathrooms to incorporate sufficient spaciousness, the requirement to accomplish plenty of tasks in this room, which at times, would leave you feeling small in this space.


text:
fou un nedador francès, especialista en estil lliure, que va competir durant la dècada de 1950. Fou el primer nedador francès en guanyar un or olímpic. Era fill de la també nedadora olímpica Bienna Pélégry.

Durant la seva carrera esportiva va prendre part en tres edicions dels Jocs Olímpics d'Estiu. El 1952, als Jocs de Hèlsinki, disputà tres proves del programa de natació. Guanyà la medalla d'or en els 400 metres lliures i la medalla de bronze en els 4x200 metres lliures, formant equip amb Joseph Bernardo, Aldo Eminente i Alexandre Jany. En els 1.500 metres lliures quedà eliminat en sèries. Quatre anys més tard, als Jocs de Melbourne, tornà a disputar tres proves del programa de natació. Destaca la sisena posició en els 1.500 metres lliures, mentre en les altres dues proves quedà eliminat en sèries. El 1960, a Roma, disputà el seus tercers i darrers Jocs, en els quals quedà eliminat en sèries en la cursa dels 4x200 metres lliures.

En el seu palmarès també destaquen quatre medalles de plata al Campionat d'Europa de natació de 1950 i 1950, sis d'or i una de bronze als Jocs del Mediterrani de 1951 i 1955 i quinze campionats nacionals, cinc dels 200 metres lliures (1951-52, 1955-56, 1958), sis dels 400 metres lliures (1950-52, 1953, 1956, 1958) i quatre dels 1.500 metres lliures (1950-51, 1956, 1958). Durant la seva carrera va establir 15 rècords nacionals i 10 rècords d'Europa.

Va morir en caure d'un arbre que estava podant al jardí de casa seva l'11 d'abril de 2010. Tenia 76 anys.

Referències

Medallistes francesos als Jocs Olímpics d'estiu de 1952
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Ultimate Dolph
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SHARKNADO 5: GLOBAL SWARMING (Anthony Ferrante, 2017, TV)
An area for discussion of Dolph's past, present & future movies!
Re: SHARKNADO 5: GLOBAL SWARMING (Anthony C. Ferrante, 2017)
by Jox on 19 Feb 2018, 23:48
SHARKNADO 6 news have emerged from the on-going Berlin film market (EFM) set for release on July 25th, no word about Dolph being it so far... Cross fingers.
http://bloody-disgusting.com/tv/3484336 ... info-date/
"All is lost, or is it? Fin unlocks the time-traveling power of the SHARKNADOS in order to save the world and resurrect his family. In his quest, Fin fights Nazis, dinosaurs, knights, and even takes a ride on Noah's Ark. This time, it's not how to stop the sharknados, it's when."
www.twitter.com/punisher_book
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by thegoon4eto on 20 Feb 2018, 18:08
Was about to post the news. Yeah, so far:
Tara Reid, Ian Ziering and Cassie Scerbo return.
No word on Dolph yet.
Van Damme fans forum
http://jcvdfans.boards.net/
thegoon4eto
by Jox on 29 Mar 2018, 14:39
'Sharknado' Franchise to End With Upcoming Sixth Film
http://variety.com/2018/tv/news/sharkna ... 202738811/
Still no word on whether Dolph will return or not... The plots and twist are so insane, they don't need him despite the final twist of the last entry...
In any case, Dolph can't have a big part because they've been shooting for 6 weeks already (director's and Tara Reid's social media). So at most they'll have him for cameo shot on green screen in LA...
(but still hopefully not)
by Jox on 25 Apr 2018, 19:43
Screen Shot 2018-04-25 at 18.41.48.jpg (116.75 KiB) Viewed 2971 times
Re: SHARKNADO 5: GLOBAL SWARMING (Anthony Ferrante, 2017, TV
by Jox on 27 Jul 2018, 18:21
With its premiere next month, I believe it's now safe to say that Dolph is NOT gonna be in SHARKNADO 6 a.k.a. THE LAST SHARKNADO: IT'S ABOUT TIME...
by Jox on 20 Aug 2018, 09:54
Jox wrote: With its premiere next month, I believe it's now safe to say that Dolph is NOT gonna be in SHARKNADO 6 a.k.a. THE LAST SHARKNADO: IT'S ABOUT TIME...
https://tv.avclub.com/the-last-sharknad ... 1828440791
Global Swarming's final act promise of Dolph Lundgren punching and shooting across time alongside Fun proves to be nothing but a beautiful lie, his presence waved away by some wibbly-wobbly timey-wimey exposition.
by thegoon4eto on 20 Aug 2018, 11:43
So, Dolph is officially not in the movie?
by bomaz on 21 Aug 2018, 12:33
*relieved sigh*
bomaz
Location: Toulouse , FRANCE
by Jox on 30 Oct 2018, 00:23
Return to Dolph's Movies
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Socialist Youth
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Tories go on the offensive against working class people
Global Inflation Spiral: A capitalist crisis that requires a socialist response
Solidarity with NHS workers: Strike together to save our NHS
Coronavirus Crisis
Tories discuss new offensive after Covid crisis – workers must not pay the price!
The Covid-19 pandemic and the subsequent shutdown – which came in the context of an already developing global economic downturn and an especially weak and failing British economy – has had massive and unprecedented consequences. According to the Office for Budget Responsibility, Britain's GDP has fallen by an estimated 35% in the immediate aftermath of the lockdown being announced.
By Paul Callanan, Socialist Alternative Political Committee
A recently leaked report from Treasury officials outlines the impact that the crisis, along with the huge state intervention that has been necessary to stave off total collapse, has had on government finances and, in particular, debt. What's more, it poses 'options' for the government as the lockdown is eased and measures such as furlough are ended.
The government finds itself in a quandary because the predicted deficit for this year is £337 billion – far in excess of the £55bn that was expected before the pandemic struck. This crisis has shown that, when it is necessary to save capitalism, enormous state spending can be produced in a matter of hours or days – without any of the restrictions the capitalist class have used to justify much of their austerity agenda. Chancellor Rishi Sunak has yet to explain how the government's wage support scheme, which has seen the state cover 80% of the wages of 8 million furloughed and self-employed workers, is to be paid for in the future, for example.
Of course, whatever course of action is set upon by the Tories will be one that ensures the interests of the bosses and super-rich are protected. This report makes it abundantly clear that it will be working class people, those who have already suffered the most because of the pandemic, who will be asked to foot the bill in the future.
One option on the table is another round of swingeing austerity. Scandalously, a two-year public sector pay freeze is one option being seriously considered. This could generate savings for the government of £6.5bn by 2023-24. It is no surprise that former Tory chancellor turned Evening Standard editor George Osborne is a big fan of this approach.
The fact that this plan is even being considered reveals the rank hypocrisy of the likes of Johnson and Sunak when they go out every Thursday and clap for NHS and care workers who are on the frontline of the crisis. It's not enough that they have been part of governments that over the last ten years have gleefully swung the axe on these services and workers. All the while demonising them. They now wish to inflict further misery.
Also being considered are eye-watering tax hikes. This is the favoured option of think tanks like the Institute for Fiscal Studies and the National Institute of Economic and Social Research. Nothing wrong with raising taxes surely? Isn't it correct that those who can afford to foot the bill are asked to pay? In any sane world, yes. But of course, what is on the table is not tax rises for the wealthy but for the working class The report also outlines what it calls a "broad based approach" which would entail an increase across all tax bands. This will hit lowest-paid workers the hardest.
The pensions triple lock, which ensures the basic state pension increases by at least 2.5% per year to keep up with inflation, is also up for grabs. The Social Market Foundation has floated this idea along with the suggested tax increases in the hopes that the burden can be shared by young and old alike! But how about, rather than targeting working-class people of any age, taking wealth from those who have managed to make a killing over the last ten years despite the hardship the majority have suffered?
The Tories are well aware that any of these approaches jar with their previous rhetoric around ending austerity. Instead they are left with praying for growth in the economy. As soon as the report got out into the public domain Johnson rushed to the backbench 1922 Committee to announce that there would be no return to austerity and that he would be "doubling down" on planned infrastructure and transport projects. He also flatly denied that the government would be freezing the wages of NHS workers.
This shows the tremendous pressure the government is under. Of course, most workers will know that promises are worthless coming from the Tories. They have already failed to deliver the PPE they promised frontline workers and are now attempting to send many workers back to their jobs at the risk of their health and safety.
The Treasury report reflects the fact that, as always, the government will seek to act in the interests of the 1%, the bosses. And their preferred method of achieving this is to prepare for a new offensive against the jobs, conditions and services of working-class people. Be that through continued austerity, a harsh new tax regime or through simply standing back and hoping for growth while millions face unemployment, loss of hours and pay cuts.
However, the fact that they have not settled on any one course of action is a reflection of a very weak government, under pressure from all sides.
At this stage the capitalist class is very nervous about the prospect of a renewal of austerity and its potential to further hamper the prospects for recovery. This is reflected in the furlough measures that the government has had to implement during the pandemic. To stave off the threat of job losses, the bosses had to call on the government to prop up wages. To not do so would have meant an immediate jobs bloodbath and an even bigger spike in unemployment than has already been seen. The catastrophic potential impact of this posed a threat not just to workers but to the profits of the bosses. They cared little that this scheme meant huge numbers of workers seeing their incomes drop by 20% – many employers were unwilling to top up wages by even this measly amount. But this meant that, when the government discussed plans to pull the plug on the scheme, they faced the threat of a huge backlash from working class people, but also from sections of the capitalist class who are currently being propped up by this state funding. As a result, the Tories were forced to extend the scheme by a further three months. Similar pressures in this direction may well be a feature of the situation as we emerge from lockdown.
Tax hikes could also have a similar effect in plunging the economy further into crisis. This is not a route the Tories will go down with any relish – not least because they are a party that falsely presents itself as being the party of lower taxes. Such an approach would threaten to alienate their own rapidly diminishing social base. What's more, in order to win the recent general election, the Tories were only able to pull themselves back from the brink of calamity based on the 'Johnson revolution' and adopting a distinct right-populist tinge.
The Tories took seats in working-class areas by cynically posing as champions of 'the people' on the issue of Brexit – and linking this with the idea of the return of decent jobs to areas devastated by decades of austerity and neoliberalism. The fragile electoral coalition Johnson assembled to win the general election will almost certainly not remain intact in the context of renewed capitalist crisis compounded by austerity.
Especially worrying for the government is the rebellion it could face from below as a result of new austerity measures. Day by day, the devastating results of cuts on public services over the past 10 years are becoming more apparent. The NHS and care services have been left totally unprepared for a pandemic on this scale. The solidarity shown by ordinary people putting themselves at risk in those sectors to care for victims of Covid-19 shows that any government attempting to attack the conditions of medical and care workers would be playing with fire.
We have also seen workers in many sectors begin to organise to fight back as the government attempts to force people back to work on unsafe transport across a number of sectors – most recently in schools. Just last week, the NEU organised an online meeting of 20,000 teachers, the biggest online trade union gathering ever, demanding 'no return until it's safe'. The most far-sighted workers, activists and trade unionists know that a growing combativity around this issue could be turned into a movement to defend jobs and pay if there was to be a renewed austerity offensive.
Whatever the course is set upon by the government and bosses, working class people need to be prepared to fight. Whatever pressure the government faces from their big-business backers, we cannot rely on them to chart a way out of this crisis in a way that will serve the interests of working class people. Quite the opposite. All the options currently being discussed at the highest levels of power involve protecting the rich and powerful and their profits.
Working class people can only rely on their collective strength and organisation. We can build on the growing experience of many workers throughout this crisis who have fought to ensure that we are not forced to work in unsafe conditions. The fact that the Tories have had to rush to deny that they are planning attacks on the public shows that this is a government attempting to hide its weak position, mortally afraid of the fact that a mass movement could beat them.
It is clear that when we emerge from lockdown, we will not be entering the world as it was before the pandemic. Workers and young people will need to go into that world armed with a political programme to change society. The new normal will be one of ever-deeper capitalist crises. We must not let the bosses clamber out of that crisis on the backs of working class people as they did in the past.
Only a socialist programme will provide full solutions, not only to a shrinking economy, but to the mass unemployment, poverty and inequality that have been the reality for the majority of people for so long. The banks and the big corporations that control the economy, and the wealth and resources in society, will not be able to ensure growth, provide jobs, services and homes while they remain in private hands.
A mass movement can fight for a society where these major monopolies are taken into public ownership and organised democratically under working-class control. Only then could ordinary people plan a way out of the Covid-19 crisis and the economic catastrophe that has arisen from it, laying the basis to build a socialist society that can meet the needs and wants of all people – not just those at the top.
#RentStrike2020 in the US — Organising against profiteering in a pandemic
Scrap the transfer tests!
Covid crisis: Precarious conditions of agency workers exposed
Early last week, word began filtering out that agencies which are employed to fill vacancies across the public sector - namely Grafton and Premiere - had sent emails to their workers telling them, "In the event of your workplace closing, your placement is finished". Furthermore, agency workers were told that, in the event of them falling ill or choosing to self-isolate to protect themselves or loved ones, they would receive only the meagre statutory sick pay (SSP) of £94/week, as opposed to the full pay that had been guaranteed to permanent public sector workers.
As the cuts bite, millions ask: 'Does it have to be like this?'
"The protesters in Athens can riot all they want, but they cannot alter the fundamental economic fact of…
byArchive
Credit rating downgrading proves that austerity isn't working
Socialists call for mass movement to stop the cuts Hannah Sell, Socialist Party deputy general secretary says: "The…
Preparing the biggest left of Labour election challenge since the war
Trade Unionist and Socialist Coalition conference It felt fitting that on 1 February, the day Labour leader Ed…
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The Dutch LATER physical outcomes set for self-reported data in survivors of childhood cancer
Nina Streefkerk1,2,
Wim J. E. Tissing2,3,
Margriet van der Heiden-van der Loo4,
Elizabeth A. M. (Lieke) Feijen1,2,
Eline van Dulmen-den Broeder2,5,
Jacqueline J. Loonen6,
Helena J. H. van der Pal2,
Cécile M. Ronckers1,2,
Hanneke M. van Santen2,7,
Marleen H. van den Berg5,
Renée L. Mulder2,
Joke C. Korevaar8 &
Leontine C. M. Kremer1,2
Journal of Cancer Survivorship volume 14, pages 666–676 (2020)Cite this article
Studies investigating self-reported long-term morbidity in childhood cancer survivors (CCS) are using heterogeneous outcome definitions, which compromises comparability and include (un)treated asymptomatic and symptomatic outcomes. We generated a Dutch LATER core set of clinically relevant physical outcomes, based on self-reported data. Clinically relevant outcomes were defined as outcomes associated with clinical symptoms or requiring medical treatment.
First, we generated a draft outcome set based on existing questionnaires embedded in the Childhood Cancer Survivor Study, British Childhood Cancer Survivor Study, and Dutch LATER study. We added specific outcomes reported by survivors in the Dutch LATER questionnaire. Second, we selected a list of clinical relevant outcomes by agreement among a Dutch LATER experts team. Third, we compared the proposed clinically relevant outcomes to the severity grading of the Common Terminology Criteria for Adverse Events (CTCAE).
A core set of 74 self-reported long-term clinically relevant physical morbidity outcomes was established. Comparison to the CTCAE showed that 36% of these clinically relevant outcomes were missing in the CTCAE.
Implications for Cancer Survivors
This proposed core outcome set of clinical relevant outcomes for self-reported data will be used to investigate the self-reported morbidity in the Dutch LATER study. Furthermore, this Dutch LATER outcome set can be used as a starting point for international harmonization for long-term outcomes in survivors of childhood cancer.
The vast majority of children diagnosed with cancer nowadays will achieve long-term survival [1, 2]. Those childhood cancer survivors (CCS) are a growing, vulnerable group of individuals who are at risk of developing long-term morbidity due to previous treatment for cancer in early stages of life. Knowledge on the burden of long-term morbidity in CCS, its underlying types of health conditions and its risk factors, has been presented in various studies during the past decades [3,4,5].
In long-term morbidity research in CCS, a broad variety of outcome assessment methods is used. Long-term morbidity outcomes can be assessed by self-reporting via questionnaires [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24], by medical evaluation during outpatient clinic visits [25,26,27,28,29,30,31,32,33,34] or by linkage with existing registries such as national hospital discharge registries [35,36,37,38,39]. Authors often include different types and different numbers of organ systems in their calculations of physical long-term morbidity [6,7,8,9,10,11,12,13,14,15,16,17,18,19,20,21,22,23,24,25,26,27,28,29,30,31,32,33,34,35,36,37,38,39]. Also, incidence or prevalence estimates are often reported without describing which health conditions or organ systems were included in these calculations. Definitions of long-term morbidity outcomes also vary, for example, authors reporting on cardiovascular conditions generally report on heart failure, myocardial infarction, and hypertension, but some also include stroke as a cardiovascular condition [10, 14, 17, 18, 36]. While many authors do not grade the severity of the reported long-term morbidity in CCS, others use the Common Terminology Criteria for Adverse Events (CTCAE) [40], either in its original form or an adapted version incorporating specific additional outcomes that authors considered missing [41,42,43]. This lack of uniformity in types of outcomes, outcome definitions, and outcome grading—even among studies that use similar data ascertainment methods—limits interpretation, comparability, and generalizability of studies investigating the burden of long-term morbidity in CCS. Furthermore, the described outcomes in current studies include asymptomatic and symptomatic outcomes with or without treatment. To get a better insight in the overall burden for survivors, the Dutch LATER questionnaire study would like to evaluate only outcomes that are symptomatic and/or requiring medical treatment.
The aim of this study is to develop a set of self-reported long-term physical outcomes that are clinically relevant for CCS, defined as morbidities with clinical symptoms and/or requiring medical treatment, to investigate the burden of morbidity in the Dutch LATER questionnaire study.
Development of draft outcomes set based on existing questionnaires and input from survivors
Three commonly used questionnaires addressing long-term morbidity in childhood cancer survivors were used for this article: the Dutch Childhood Oncology Group—Long-Term Effects After Childhood Cancer (Dutch LATER) study questionnaire which was used in the Dutch LATER research program [44], the Northern American Childhood Cancer Survivor Study questionnaire [45], and the British Childhood Cancer Survivor Study questionnaire [46]. See Supplementary Tables S1–S3 for the respective items. In long-term morbidity research, the Childhood Cancer Survivor Study questionnaire was used either in its original form [6,7,8, 10, 12,13,14,15, 18, 20, 22, 24, 47,48,49,50,51,52] or adapted by authors for their own specific study [9, 21, 53]. The questionnaires covered multiple dimensions of late side effects. For this article, we focused on self-reported physical outcomes, covered by the questionnaire sections on medical history and health conditions.
The methods of comparing the three long-term morbidity questionnaires and selection of self-reported long-term physical outcomes for CCS are summarized in Fig. 1. We condensed all outcomes from the three questionnaires into 15 categories. All but two were defined per organ system, i.e., conditions of the eye, ear, speech, cardiac, vascular, pulmonary, gastro-intestinal, hepatic, renal and urinary tract, endocrine, musculoskeletal, neurologic conditions, and other conditions. In addition, surgical procedures and malignancies were considered (Supplementary Table S4). We listed the concordances and discordances in outcomes embedded in the three aforementioned questionnaires.
Overview steps followed in the process of development of patient reported outcome list for research for physical long-term morbidity in childhood cancer survivors
The draft outcome set consisted of a selection of (concordant and discordant) outcomes. Next, we reviewed all health conditions that were reported in the open text fields by CCS participating in the Dutch LATER questionnaire study and added these outcomes to the draft outcome set by outcome category. Temporary or self-limiting morbidities, for example, urinary tract infections, pneumonia, and runner's knee, were not considered as potential outcomes due to their transient nature and were, therefore, removed from the draft outcome set. Childhood cancer-directed surgeries impacting CCS in later life, for example, limb amputation which results in a lifelong disability or removal of an eye which results in lifelong complications, were added to the draft outcome list. Also, obesity and underweight were added because they were no self-reported outcome in the aforementioned questionnaires.
Selection of self-reported long-term physical outcomes for CCS
The draft outcome set was reviewed in detail by the Dutch LATER experts team, which comprised a multidisciplinary team of late effects clinicians (pediatric oncology and medical oncology), late effects researchers, a pediatric endocrinologist, and a survivor representative, all of whom are involved in the late effects research. The experts team focused on health conditions that were relevant for childhood cancer survivors, i.e., health conditions that influence their daily life, either by resulting in symptoms or by requiring medical treatment. A proposal for a core outcome set was established by agreement by two authors (N.S. and L.F.), which was discussed by the experts team in a phone meeting. During this meeting, agreement was established regarding a final core set, containing all outcomes deemed relevant for survivors.
Subsequently, for each outcome in the core set, definitions for clinical relevance were established by three authors (N.S., L.F., and L.K.), based on outcome-specific (potential) clinical symptoms and/or (potential) medical treatment. For obesity and underweight in adults, clinical relevance was defined according to the definitions used by the World Health Organization. These definitions were discussed by the experts team by e-mail, until agreement was reached for all clinical relevance criteria.
Comparison between CTCAE and the new Dutch LATER core outcome set
The CTCAE, originally developed to score acute treatment toxicities [40, 54], is commonly used to grade the severity of outcomes in survivorship studies. This terminology comprises a 5-point grading scale for many adverse events, which are defined as unfavorable and unintended signs, symptoms, or disease, associated with the use of medical treatment. Severity grades rank from 1 (mild, asymptomatic or mild symptoms; clinical or diagnostic observations only; intervention not indicated) to 5 (death related to adverse event) [40]. To gain insight in the agreement between our newly defined outcome set and CTCAE grading, we added the CTCAE grade based on version 4.03 corresponding to our outcome definition for every proposed physical long-term morbidity outcome. Recently, researchers from the St. Jude Lifetime Cohort Study (SJLIFE) adjusted the CTCAE criteria to grade long-term morbidity in their cohort for which data was obtained during clinical assessment using multiple diagnostic modalities. To get insight in concordance between the CTCAE outcomes and the Dutch LATER core outcome set, we compared the different lists of outcomes.
Selection of self-reported long-term physical outcomes of clinical relevance
The process of selection of self-reported clinically relevant physical long-term physical outcomes, as displayed in Fig. 1, resulted in a core outcome set consisting of 74 proposed outcomes. The experts team decided on re-categorizing surgical procedures within their respective organ system and did not consider conditions of speech as clinically relevant. Therefore, the 15 initial outcome categories were re-categorized into 13 proposed main organ system categories: conditions of the eye, ear, cardiac, vascular, respiratory, gastro-intestinal, hepatobiliary tract, renal and urinary tract, endocrine, musculoskeletal, nervous system conditions, other conditions, and neoplasms (see Table 1).
Table 1 Core set of self-reported long-term physical outcomes of clinical relevance for childhood cancer survivors
Agreement between the newly defined core outcome set and the CTCAE grading
For each outcome, the minimum CTCAE grades that correspond with our criteria for clinical relevance are shown in Supplementary Table S5. In all, 27 out of 74 (36%) outcomes cannot be graded according to CTCAE because they are not present in the CTCAE as a separate entity. This group of outcomes can be categorized into three subgroups. First, it comprised certain surgeries of which the LATER experts team agreed upon clinical relevance (n = 18), because they influence CCS's daily life either by having medical consequences (e.g., splenectomy or organ transplantations) or by having cosmetic consequences (e.g., eye enucleation or limb amputation). Second, it comprised blindness and deafness, which are included in the CTCAE not as a specific outcome but as grading scale for several specific other eye and ear/nose/throat outcomes. The LATER experts team agreed that regardless of the underlying pathophysiological mechanism, blindness and deafness were both clinical relevant outcomes that should be included in the core outcome set. Third, specific outcomes that were not present as separate entities in the CTCAE were reported by CCS in the Dutch LATER questionnaire and were perceived as clinically relevant by the experts team (n = 7): aortic aneurysm, liver cirrhosis, tubular dysfunction of the kidneys, prolactinoma, polycystic ovarian syndrome, underweight, and pituitary dysfunction.
Of the remaining 48 conditions, 11 (15%) fulfilled the definition for conditions with a CTCAE grade 3, that is, severe or medically significant but not immediately life-threatening. For 27 (36%) conditions, our criteria for clinical relevance corresponded with a CTCAE grade 2, moderate severity. For nine (12%) conditions (decreased pulmonary function, proteinuria, chronic kidney disease, precocious puberty, diabetes mellitus, ischemic cerebrovascular accident, transient ischemic attack, epilepsy, and headache), it was not possible to define the corresponding CTCAE grade for our established clinical relevance criteria, because additional clinical information was needed for CTCAE-based grading. Comparison to the SJLIFE-based grading showed that 34 conditions from our core set were not present in SJLIFE (46%) and additional information was needed for grading of 5 conditions (7%). A total of 23 clinically relevant conditions corresponded with SJLIFE grade 2 (31%) and two clinically relevant conditions (adrenal insufficiency and growth hormone deficiency) corresponded with SJLIFE grade 1 (3%).
We present a proposal for a core set of 74 self-reported long-term physical outcomes of clinical relevance in survivors of childhood cancer. By comparison of existing survivorship questionnaires and by reviewing every specific morbidity reported by CCS in the open text fields in our Dutch nationwide questionnaire study, we followed an innovative method which focuses on outcomes that are clinically relevant for the survivor, due to the fact that its presence influences daily life. Our outcome set will be used for investigating the burden of long-term morbidity in the Dutch LATER questionnaire study. This set can also be used for international harmonization of a uniform core outcome set for long-term morbidity in CCS, to facilitate worldwide collaboration in late effects research.
Compared with other grading scales used for long-term morbidity research in CCS, the newly developed Dutch LATER core outcome set differs on three important key points. First, this core outcome set was designed with the single purpose of investigating self-reported long-term morbidity in childhood cancer survivors, by combining existing questionnaires and outcomes reported by survivors. Second, we selected outcomes describing morbidity with clinical symptoms or requiring medical treatment, the so-called clinically relevant outcomes. Third we included outcomes where the treatment for childhood cancer caused direct damage that had persistent impact for the survivor also in later life, for example, limb amputation which results in a lifelong disability or removal of an eye which results in lifelong complications. Because the CTCAE criteria were originally designed for grading acute adverse events during adult cancer trials [54], the current CTCAE version 4.03 [40] does not cover the complete spectrum of long-term morbidity that CCS might encounter [42]. Several authors have already stated that relevant outcomes were missing for CCS and use adapted versions [41,42,43]. Comparison of our core set of long-term self-reported physical outcomes to the commonly used CTCAE showed that 36% of the outcomes were not present in the CTCAE. Moreover, CTCAE does not incorporate self-reported data to assess long-term morbidity [42]. For nine out of the 48 conditions that were present in the CTCAE, we could not perform severity grading because detailed additional clinical information was needed for appropriate grading, which was not available from current questionnaires and is often too complicated to directly ask patients in a questionnaire. Although often only health conditions grade 3 and higher are included when studying severe physical long-term morbidity in CCS, our results show that many grade 2 conditions will have consequences for a survivor because of symptoms or needed treatment. From our core outcome set, up to 27 clinically relevant outcomes corresponded with CTCAE grade 2, for example, several endocrine deficiencies that require chronic medication use, and would have been missed in such studies. Comparison to the SJLIFE adapted CTCAE for grading of clinically ascertained data showed that more of our core outcomes were missing and that 24 clinically relevant conditions corresponded to grade 2 or even grade 1. Hence, our results support previous authors, concluding that the CTCAE in its current form is not optimal to grade severity of (self-reported) long-term physical morbidity outcomes for CCS [41,42,43]. To our knowledge, this is the first comprehensive proposal to define a core outcome set for self-reported long-term physical outcomes in CCS. A strength of this study is that we focused on clinical relevance for CCSA and a limitation is that we were not yet able to incorporate the prioritization of outcomes by survivors. This can be the focus of future research. Also, because the purpose of this core outcome set was facilitating the investigation of physical long-term morbidity in the Dutch LATER cohort, the proposed outcome definitions reflect the agreement among the Dutch LATER experts team only. To overcome any subjectivity in outcomes used by various childhood cancer survivorship research groups, we advocate international harmonization of a core outcome set for physical long-term morbidity in childhood cancer survivors. A uniform global core outcome set is highly needed to enable comparison of future long-term morbidity studies, to uniformly evaluate survivorship care and to facilitate collaboration within survivorship research. The International Guideline Harmonization Group [55] started an initiative to develop a harmonized outcome set by a Delphi method. This will facilitate international collaboration and data pooling.
In conclusion, we propose a Dutch LATER core set of self-reported long-term physical outcomes of clinical relevance for CCS that will be used to investigate the burden of long-term morbidity in childhood cancer survivors from the Dutch LATER questionnaire study. We advocate to start international discussion and research to harmonize long-term physical morbidity outcomes that are clinically relevant for CCS.
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Nina Streefkerk is supported by the Dutch Cancer Society (Grant No. UVA2014-6805).
Cecile Ronckers is supported by the Dutch Cancer Society (Grant No. UVA2012-5517).
Department Pediatric Oncology, Amsterdam UMC, Emma Children's Hospital, University of Amsterdam, Amsterdam, The Netherlands
Nina Streefkerk, Elizabeth A. M. (Lieke) Feijen, Cécile M. Ronckers & Leontine C. M. Kremer
Princess Máxima Center for Pediatric Oncology, Heidelberglaan 25, 3584 CS, Utrecht, The Netherlands
Nina Streefkerk, Wim J. E. Tissing, Elizabeth A. M. (Lieke) Feijen, Eline van Dulmen-den Broeder, Helena J. H. van der Pal, Cécile M. Ronckers, Hanneke M. van Santen, Renée L. Mulder & Leontine C. M. Kremer
Department of Pediatric Oncology/Hematology, Beatrix Children's Hospital/University of Groningen/University Medical Center Groningen, Groningen, The Netherlands
Wim J. E. Tissing
Dutch Childhood Oncology Group, Utrecht, The Netherlands
Margriet van der Heiden-van der Loo
Department of Pediatric Oncology/Hematology, Amsterdam UMC, Vrije Universiteit Amsterdam, Amsterdam, The Netherlands
Eline van Dulmen-den Broeder & Marleen H. van den Berg
Department of Hematology, Radboud University Medical Center, Nijmegen, The Netherlands
Jacqueline J. Loonen
Department of Pediatric Endocrinology, Wilhelmina Children's Hospital, University Medical Center, Utrecht, The Netherlands
Hanneke M. van Santen
Netherlands Institute for Health Services Research, Utrecht, The Netherlands
Joke C. Korevaar
Nina Streefkerk
Elizabeth A. M. (Lieke) Feijen
Eline van Dulmen-den Broeder
Helena J. H. van der Pal
Cécile M. Ronckers
Marleen H. van den Berg
Renée L. Mulder
Leontine C. M. Kremer
All authors contributed to the design and data collection of the study. All authors contributed to the interpretation of data. NS, EF, MvdHL, JK, WT, RM, and LK drafted the manuscript and all other authors critically revised the manuscript. All authors approved the final version.
Correspondence to Nina Streefkerk.
Data used for this study was not publicly available.
The LATER questionnaire study was declared exempt from review of medical intervention research by the Medical Ethics Committee of the VU University Medical Center of Amsterdam and by the boards of all participating centers. All LATER questionnaire participants gave written informed consent.
ESM 1
(DOC 1.36 mb)
Streefkerk, N., Tissing, W.J.E., van der Heiden-van der Loo, M. et al. The Dutch LATER physical outcomes set for self-reported data in survivors of childhood cancer. J Cancer Surviv 14, 666–676 (2020). https://doi.org/10.1007/s11764-020-00880-0
Accepted: 25 March 2020
Issue Date: October 2020
Childhood cancer survivors
Long-term morbidity
Outcome assessment
Outcome definition
Not affiliated


text:
: AstraZeneca now says its COVID-19 vaccine is 76% effective
By March 25, 2021 139 views
18237500 - businessman hand pointing to investment as concept
AstraZeneca PLC, which has been under fire for the accuracy of its data, on Wednesday night announced updated Phase 3 trial data of its coronavirus vaccine, saying it's 76% effective at preventing symptomatic COVID-19.
AZN,
also said its vaccine had 100% efficacy against severe disease and hospitalizations, and that for patients older than 65, it had 85% efficacy against the virus.
"Positive high-level results from the primary analysis of the Phase III trial of AZD1222 in the U.S. have confirmed vaccine efficacy consistent with the pre-specified interim analysis announced on Monday," the company said in a statement, adding that it would submit its data for emergency-use authorization to the U.S. Food and Drug Administration in the coming weeks.
On Monday, the British drug maker said its vaccine had a 79% efficacy rate. But Monday night, the U.S. National Institute of Allergy and Infectious Diseases said it was concerned that AstraZeneca had released "outdated information," and the company was accused of cherry-picking data.
At the time, the company said the figures were based on a "pre-specified interim analysis" and said it would share the results of "a primary analysis with the most up-to-date efficacy data" on Thursday.
Earlier Wednesday, Dr. Anthony Fauci — who is the head of the NIAID — said AstraZeneca's vaccine is good, even if its efficacy rate wasn't as high as it originally claimed. "At the end of the day, you know, when you look at the data, this is going to turn out to be a good vaccine," Fauci said during Wednesday's White House COVID-19 briefing.
"The primary analysis is consistent with our previously released interim analysis, and confirms that our COVID-19 vaccine is highly effective in adults," AstraZeneca executive Mene Pangalos said in a statement Wednesday.
AstraZeneca's vaccine has also been the subject of worry over possible blood clots. But an EU regulator last week declared the drug "safe and effective," and in its announcement Wednesday night, the company said "The vaccine was well tolerated, and no safety concerns related to the vaccine were identified."
AstraZeneca's data came from a study of more than 32,000 people.
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Andrea B. Scott is a filmmaker and editor based in Brooklyn, New York. Her feature length directorial debut, Florence, Arizona, premiered at the 2014 DOC NYC. She has edited such films as Fresh Dressed, Hot Girls Wanted, and A Place at the Table, all of which premiered at the Sundance Film Festival. She is currently at work on a series of short films, and is editing a feature length documentary about a bird hoarder.
Law enforcement's treatment of dogs is just a symptom of the militarized policing so many of our neighborhoods are subjected to.