In a stunning turn of events, FDA commissioner Scott Gottlieb is resigning from his post and leaving office in a matter of weeks.
The Washington Post reported that Gottlieb, who's been commuting from Connecticut, told administration officials that he wants to spend more time with his family.
Gottlieb arrived at the FDA shortly after the Trump administration took office, vowing to uphold the gold standard in drug development while doing everything possible to facilitate drug makers' work — at least for the legitimate players.
He has been enormously popular in his short stint, with the vast majority of biopharma execs acclaiming his work at the agency. He's also been popular with President Donald Trump, finding a secure spot for himself in an administration noted for rapid turnover.
We've got a lot important policy we'll advance this year. I look forward to sharing my 2019 strategic roadmap soon.
The big question now is who will replace him. Trump freaked out many execs by entertaining Peter Thiel's push for a libertarian approach, which would have erased many of the barriers to introducing new drugs — along with the credibility that goes with an FDA sanction. Trump, though, has many open positions in his administration, including Cabinet-level posts. Stephen Ostroff has taken the helm on a strictly interim basis before, but he retired last fall, replaced by Walmart executive Frank Yiannas.
Gottlieb's letter of resignation includes his list of accomplishments for the past 23 months, from a record number of new drug approvals to their continued work on mastering new technologies and taking on e-cigarette use by minors.
I'm confident that the FDA will continue to advance all these efforts, and many other goals.
Industry leaders quickly noted the significance of the move today.
"We're going to miss him. He was a terrific leader of the FDA," Alnylam CEO and BIO chairman John Maraganore told me.
"It's a damn shame," Tweeted longtime serial entrepreneur Mike Gilman, echoing the sharp level of disappointment about the news.
There are plenty of qualified people that this doesn't need to be a negative. But the thing I do worry about with the environment in Washington these days is that it will take forever for the next person to get approved.
….Scott has helped us to lower drug prices, get a record number of generic drugs approved and onto the market, and so many other things. He and his talents will be greatly missed!
This is really terrible news. Gottlieb has done so much in such a short period of time, and I think that most of us in the industry viewed him as a force for good, an innovator, and someone with integrity and intelligence. Personally, I viewed him as one of the best people in the administration. This is a big loss for all of us.


Are there any plans to merge PSoC Creator with PSoC Designer??, it is really a time waste to have two design paltforms. PSoC designer is very boring to learn.
That sounds like a pretty good idea, but aren't the chips too different?
We used to use PSOC1 but perfer to use PSOC3 now. as there is no need to get the ICE and no need to get the foot for different packages. My guess is more and more people would switch to PSOC3 and PSOC5 although the chip is more expensive, but save time during development of PCB and hardware, So more people woud switch to Creator.
Assembly programming is still offers the option to build the smallest code but it comes at an incredible price of taking much longer and being more error-prone.
My preference is Creator, no doubt but because PSoC 1 devices are much simpler than PSOC 3 or PSoC 5, there is a case to make for a more control design environment.
Tools evolve with the silicon improvements. Cypress in a sense at a crossroads.
given them a 10X boost in core, a X boost in analog process. And merged digital signal processing to boot.
new tool , the new process ? You decide.
Designer gave us API calls we no longer had to write, duplicate, regurgitate, over and over and over….……ech.
course VERILOG, no parallel in Designer.
PSOC 1 still great for low end low cost designs. Until such time as Cypress decides to drop an old process.


text:
Syngenta CEO leaves in wake of Monsanto deal rejection
ZURICH - Syngenta <SYNN.VX> Chief Executive Mike Mack is stepping down as head of the Swiss agrochemicals group just two months after the company spurned a $47 billion takeover approach from U.S. rival Monsanto <MON.N>.
Syngenta Chief Executive Officer Michael Mack (left) has informed the Swiss company's board of his intention to step down. Mack will leave at the end of the month. REUTERS/Arnd Wiegmann/Files.
By Brenna Hughes Neghaiwi/Reuters
Mack, who is 55, will quit at the end of the month and Chief Financial Officer John Ramsay will take charge on an interim basis, the company said in a statement on Wednesday.
Shares were up 4.4 percent at 323.60 Swiss francs at 0840 GMT following the announcement, with traders saying the change could rekindle bid speculation.
But a source close to Syngenta said that, as Ramsay is not a member of the board and is unlikely to become one, the board's attitude toward a takeover was unlikely to change.
Syngenta, the world's largest maker of pesticides has been under pressure to boost shareholder returns after rejecting the possible deal with rival Monsanto <MON.N>.
A group of rebel Syngenta shareholders said the change could benefit the company.
"We welcome the decision because it shows that somebody takes responsibility," said Folke Rauscher, managing director of a group calling itself the "Alliance of Critical Syngenta-Shareholders". http://www.critical-syngenta-shareholders.com/en-us/
"It opens up new perspectives in terms of exploiting all options to fully get Syngenta's potential back," Rauscher told Reuters. The group says it now has the support of more than 80 Syngenta shareholders since it was set up earlier this month.
The Swiss group's troubles were compounded last week when it reported third-quarter sales that fell more than expected.
"I believe that this is an appropriate time for the company to benefit from the perspectives of a new leader," Mack said in a company statement on Wednesday, calling current market conditions challenging.
"I wish John (Ramsay) every success in his new role," added Mack, an American who had been in the top job since 2008.
Analysts linked Mack's departure to Monsanto's spurned takeover bid as well as disappointing third-quarter earnings and said that the company should hire externally.
"In our view, it would be best to appoint an industry insider - but outside person - with a fresh viewpoint on Syngenta," Kepler Cheuvreux wrote in a note.
"We do not believe that just because of Mike Mack's decision to retire from Syngenta, Monsanto will develop novel short-term ambitions on Syngenta again."
Syngenta's shares dropped 23 percent on the day that Monsanto announced it was abandoning its pursuit of the Swiss company, and in the last month the shares have traded at between 288 and 322 Swiss francs ($301-337), down from 400 francs in August.
The Monsanto approach equated to a price of around 433 Swiss francs per Syngenta share.
In September the company unveiled plans to buy back more than $2 billion of stock to boost shareholder returns after rejecting Monsanto's takeover approach, and put its vegetable seeds business up for sale to fund the measure.

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: C# In memory databases share indexes? So I'm working on testing parts of my code adding and removing data in my database. I'm setting up an In memory database for each unit test to make sure that I got a completely "clean slate" for each test. However, I have encountered a very weird issue. I have omitted some code below but it shows my general approach:
[TestFixture]
internal class EventControllerTest
{

    [Test]
    public void CreateEventController()
    {
        var options = new DbContextOptionsBuilder<ApplicationDbContext>()
            .UseInMemoryDatabase(databaseName: "CreateEventController1")
            .Options;
        var context = new ApplicationDbContext(options, null);

        //Add eventType.
        realEventService = new EventService(context, currentUserService.Object);
        realEventService.CreateEventType(new EventTypeData
        {
            Color = "Pink"
        });
        //ASSERTS
    }

    [Test]
    public void GetEventController()
    {
        var options = new DbContextOptionsBuilder<ApplicationDbContext>()
            .UseInMemoryDatabase(databaseName: "GetEventController1")
            .Options;
        var context = new ApplicationDbContext(options, null);

        //Add eventType.
        realEventService = new EventService(context, currentUserService.Object);
        realEventService.CreateEventType(new EventTypeData
        {
            Color = "Pink",
        });
      //ASSERTS
    }
}

Now, If I run each of these tests by themselves, they pass as I originally check the Id of the EventType, they are both 1. However, if I run all my test in sequence, my second test fails. It fails because the EventType that it adds actually has the id of 2 and not 1! However, the database only contains one entry of an EventType. I have separate names on the databases and to my understanding, this means that they are entirely different. And yet, the auto-incremented index is for some reason just increased and used in my second test. So to clarify:

*

*If I run CreateEventController() its EventType entry gets the id of
one.

*If I run GetEventController() its EventType entry gets the id of
one.

*If I run CreateEventController() and then GetEventController(),
the EventType entry in CreateEventController() is 1 and the EventType
entry id in GetEventController() is 2!

How can I separate these databases entirely?

A: Looks like an open issue / bug: https://github.com/aspnet/EntityFrameworkCore/issues/6872
They do offer an extension method as a fix (code lifted as is from there):
public static class DbContextExtensions
{
    public static void ResetValueGenerators(this DbContext context)
    {
        var cache = context.GetService<IValueGeneratorCache>();
        foreach (var keyProperty in context.Model.GetEntityTypes()
            .Select(e => e.FindPrimaryKey().Properties[0])
            .Where(p => p.ClrType == typeof(int)
                        && p.ValueGenerated == ValueGenerated.OnAdd))
        {
            var generator = (ResettableValueGenerator)cache.GetOrAdd(
                keyProperty,
                keyProperty.DeclaringEntityType,
                (p, e) => new ResettableValueGenerator());

            generator.Reset();
        }
    }
}

public class ResettableValueGenerator : ValueGenerator<int>
{
    private int _current;

    public override bool GeneratesTemporaryValues => false;

    public override int Next(EntityEntry entry)
        => Interlocked.Increment(ref _current);

    public void Reset() => _current = 0;
}

To use, call context.ResetValueGenerators(); before the context is
  used for the first time and any time that EnsureDeleted is called. For
  example:

using (var context = new BlogContext())
{
    context.ResetValueGenerators();
    context.Database.EnsureDeleted();

    context.Posts.Add(new Post {Title = "Open source FTW", Blog = new Blog {Title = "One Unicorn"}});
    context.SaveChanges();
}

redpajama_set_name: RedPajamaStackExchange


text:
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Home Science Tech Meet Telomerase, the Immortality Enzyme in Your Chromosomes
ScienceTech
Meet Telomerase, the Immortality Enzyme in Your Chromosomes
By Vision Times Staff
Telomerase is found at the end of chromosomes. (Image: pixabay / CC0 1.0)
Life takes birth, decays, and dies. This is true for all living creatures. However, we might have found a way to cheat the decay process, allowing us to almost stay immortal. This is possible due to telomerase, an enzyme found at the end of chromosomes that plays a critical role in the aging process.
The immortality enzyme
Human cells contain 23 pairs of chromosomes. To prevent these chromosomes from fusing into each other, they are capped off with a series of repeated nucleotide sequences called telomerase. Each time a cell divides in your body, the chromosomes are copied. But they are not copied completely.
"Each time the cell divides, the telomeric DNA shrinks and will eventually fail to secure the chromosome ends. This continuous reduction of telomere length functions as a "molecular clock" that counts down to the end of cell growth. The diminished ability for cells to grow is strongly associated with the aging process, with the reduced cell population directly contributing to weakness, illness, and organ failure," according to Science Daily.
In most adult cells, telomerase is not switched on at all. It is only active in egg cells, sperm cells, stem cells, and embryo cells. If scientists find a way to block the telomerase from deteriorating, they might succeed in stopping the aging process. Organ deterioration would also stop. One way to do this is by adding telomerase to adult cells. A study that tested this hypothesis found that cells into which telomerase was introduced replicated more than 20 times their regular life span.
The ability to control telomerase will also help in combating cancer. (Image: pixabay / CC0 1.0)
Discovering a drug that would target only telomerase is a tricky process since this will require a knowledge of how the enzyme looks. Scientists have been successful in getting high-resolution images of telomerase. As such, anti-aging drugs might be a possibility a decade or two down the line. Another area where telomerase drugs would be useful is in cancer treatment. Cancer cells have the ability to switch on their telomerase, which is what allows them to keep growing uncontrollably. If we can deactivate telomerase in the cancer cells, the disease can be successfully stopped to a good extent.
In a recent immortality breakthrough, scientists from the University of Cambridge succeeded in reversing the aging process in rat brain stem cells. The team discovered that when they implanted old brain stem cells into the soft brains of young rats, the cells got rejuvenated.
Scientists have successfully resurrected the brains of dead pigs. (Image: via pixabay / CC0 1.0)
"We were fascinated to see that when we grew young, functioning rat brain stem cells on the stiff material, the cells became dysfunctional and lost their ability to regenerate, and in fact began to function like aged cells," Kevin Chalut, who co-led the research, said to the Daily Star. The scientists hope that their research will eventually aid in the development of a treatment for multiple sclerosis (MS).
Another team of scientists shows success in resurrecting pig brains. The team obtained the brains of 32 pigs from a slaughterhouse and artificially pumped blood into the organs. Over six hours, the scientists observed that the death rate of brain cells had come down. In addition, some of the cellular functions had also revived. The research points to the possibility that brain activities could be restored, at least partially, even after a person has died.
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Vision Times Staff
Vision Times is a kaleidoscopic view into the most interesting stories on the web. We also have a special talent for China stories — read About Us to find out why. Vision Times. Fascinating stuff.
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Zalman Fan Resistor Cable is a high quality fan resistor cable which is used to slow down any sized standard 12V case fan with a 3-pin connector. It reduces the voltage to 7V to slow down the fan speed and also creates a 3.5" extension to your cable length while also saving space for other important components of your system.
It doesn't work with zalman 9900 first gen..
I bought it thinking it would work on my zalman 9900.. Since it didn't come with one. Turns out only the newer models zalman cnps9900aled works with it.. You can see it has 3 holes for input/output. The original zalman 9900 has 4.. The cnps9900aled already comes with one of these so no need to purchase it. So, for those of you who are thinking of buying this hoping to make your cpu fan quieter on high speed, do your homework.. Luckily it only costs $4.00 so i'm not going to bother with returning it.
Worked well, but it got a little toasty. If i made it myself, i would have used a higher wattage capacity resistor.
Does exactly what it's supposed to slow for 3 pin fan control through motherboard.
Resistor cable was just what I needed, price was less than cost of shipping. I chose the cheapest shipping option, UPS-Mail Innovations; I hate that service. Delivery was actually earlier than indicated, but tracking is a problem using this service.


We as a country spend a lot of our federal tax dollars on medical care. Medicare, medicaid and the affordable care act (Obamacare) are large parts of that spending.
Much of that care money is spent on the hard work that our country's nurses provide. But they are human beings and not robots in an assembly line. There is a physical limit to what they can do to deliver optimal care to patients.
National Nurses United(NNU) — the largest union of registered nurses in the country — is proud to announce the introduction today in the U.S. Senate by Sen. Sherrod Brown (S.1063) and in the U.S. House of Representatives by Rep. Jan Schakowsky (H.R. 2392) NNU-sponsored legislation setting specific safety limits on the numbers of patients each RN can care for in hospitals throughout the U.S.
The bills, both known as the Nurse Staffing Standards for Hospital Patient Safety and Quality Care Act, establish minimum RN-to-patient ratios for every hospital unit at all times. They also provide whistleblower protection to assure that nurses are free to speak out for enforcement of safe staffing standards.
Also here is a link to our Signup Form to subscribe to our list.


text:
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text:
» Alternating Hemiplegia of Childhood (AHC)
Alternating Hemiplegia of Childhood (AHC)
In 1971 Verret and Steele reported eight patients they have followed from 1953 up to 1969, that suffer from intermittent hemiparesis beginning from infancy or early childhood. The authors suggested that , instead, these cases present a distinct clinical entity, namely Alternating Hemiplegia (in) Childhood and it should be differentiated from convulsive disorders based on the specific profile of the symptoms and when no seizure activity is recorded on EEGs and cerebral artheriography is normal.
Bourgeois, Aicardi and Goutières studied 22 patients in France and in 1993 and established the clinical diagnostic criteria for Alternating Hemiplegia (of) Childhood:
onset before 18 months of age;
occurrence of hemiplegia, tonic or dystonic attacks, nystagmus, dyspnea and other autonomic phenomena;
dissapearence of these symptoms with sleep and reappearence 10 to 20 minutes after awakening;
episodes of quadriplegia that occuring either when a hemiplegia shifts from one side to the other or as an isolated manifestation;
development of cognitive impairment and of a choreoathetotic movement disorder.
AHC1: In 2004, in a kindred with a complex phenotype including AHC and seizures, Bassi et al and Swoboda et al found a novel heterozygous mutation in the ATP1A2 gene, coding for the a2 subunit of the Na,K pump. None of the tested typical AHC cases however was found positive for ATP1A2 gene mutations.
AHC2: In 2012, several labs (Heinzen et al, Rosewich et al, Genome Diagnostics Nijmegen, Ishii et al.) used next-generation sequencing (NGS) to screen for de novo mutations in AHC patients and identified missense mutations in the ATP1A3 gene in the majority of these cases.


The National Law Journal has named two verdicts achieved by Lieff Cabraser trial lawyers to its list of the Top Verdicts of 2014. Both trials occurred in federal court in Florida as part of the so-called Engle cases, the Florida class action filed against the cigarette companies in 1994.
In its annual spotlight on the plaintiffs' bar, The National Law Journal has selected Lieff Cabraser as one of top plaintiffs' law firms in the nation for 2015. The award marks the twelfth year that the NLJ has named Lieff Cabraser to its Plaintiffs' Hot List.
Photo: Lieff Cabraser attorneys (left to right) Sarah London, Lexi Hazam, Paulina do Amaral, and Annika K. Martin at the 2014 Women En Mass conference in Colorado.
The legal industry at the partnership level across all practice areas predominantly consists of male lawyers. According to the National Association of Women Lawyers, only 17 percent of partners at the nation's largest 200 firms are female.


text:
SAA Philip M. Hamer and Elizabeth Hamer Kegan Award
Home Uncategorized SAA Philip M. Hamer and Elizabeth Hamer Kegan Award
2020 Free Emergency Preparedness and Response Workshops
Contact the House in Support of Increased Funding for the National Archives and NHPRC
The Philip M. Hamer and Elizabeth Hamer Kegan Award Subcommittee of the Society of American Archivists (SAA) seeks nominations for the 2020 award.
This Philip M. Hamer and Elizabeth Hamer Kegan Award recognizes an archivist, editor, group of individuals, or institution that has increased public awareness of a specific body of documents (which can be a specific archival collection or thematic aggregation) through compilation, transcription, exhibition, or public presentation of archives or manuscript materials for educational, instructional, or other public purpose. Work that has had an impact on a local, regional, national, and/or international level is welcomed.
Recent winners include:
2019: Dickinson College Archives and Special Collections for Carlisle Indian School Digital Resource Center
2018: Find & Connect, eScholarship Research Centre
2017: Center for Home Movies
2016: South Asian American Digital Archive
2015: The Legacy Center, Drexel University College of Medicine, for Doctor or Doctress?
2014: Emma Goldman Papers Project
2013: Densho, The Japanese American Legacy Project
2012: Immigration History Research Center, University of Minnesota for Digitizing Immigrant Letters
Eligibility: Individual archivists and editors, groups of individuals, organizations. This award is open to nominees within and outside of the United States, and is not limited to SAA members.
Prize: A certificate and a cash prize of $500.
Application Deadline: All nominations shall be submitted to SAA by February 28 of each year.
For more information on this award, including the nomination form, please go to:
http://www2.archivists.org/governance/handbook/section12-hamer
For more information on SAA awards and the nominations process, please go to:
https://www2.archivists.org/aboutsaa/awardsandscholarships.


text:
The National Survey of Trabeculectomy. III. Early and late complications
B. Edmunds, J. R. Thompson, J. F. Salmon, R. P. Wormald
Purpose There is a considerable body of literature relating to trabeculectomy, however there are no data representative of the national experience of trabeculectomy in the United Kingdom (UK). The Department of Health funded a national survey of trabeculectomy to establish current practice patterns and the outcome of trabeculectomy in the National Health Service (NHS). In this paper we present the reported complications of first-time trabeculectomy from a nationally representative cohort of patients with chronic open angle glaucoma. Methods Cross-sectional study of consultant ophthalmologists performing trabeculectomy in the NHS. Participants recruited their four most recent consecutive first-time trabeculectomy cases with chronic open angle glaucoma according to study eligibility criteria and data were collected by self-administered questionnaire. Follow-up: one year post-trabeculectomy. Main outcome measures: occurrence of early and late complications. Results: Clinical outcome data were available for 1240 (85.3%) of cases. Early complications were reported in 578 (46.6%) cases and late complications in 512 (42.3%) cases. Some cases had more than one complication. The most frequent early complications were hyphaema (n = 304, 24.6%), shallow anterior chamber (n = 296, 23.9%), hypotony (n = 296, 24.3%), wound leak (n = 216, 17.8%) and choroidal detachment (n = 175, 14.1%). The most frequent late complications were cataract (n = 251, 20.2%), visual loss (n = 230, 18.8%) and encapsulated bleb (n = 42, 3.4%). The occurrence of most complications was not associated with a consultant's specialist interest, level of activity, type of hospital or region. Encapsulated bleb was reported more frequently in a university hospital setting. Conclusions The complication rates reported in this paper represent the national experience of first-time trabeculectomy for open angle glaucoma in the UK. These are similar to previous published studies and highlight in particular, the impact of trabeculectomy on visual acuity in the first year following surgery. This survey provides valid and clinically relevant data on the complications of trabeculectomy for the production of guidelines and standards for audit at regional, local and individual level.
https://doi.org/10.1038/sj.eye.6700148
National survey
Visual loss
10.1038/sj.eye.6700148
Dive into the research topics of 'The National Survey of Trabeculectomy. III. Early and late complications'. Together they form a unique fingerprint.
Trabeculectomy Medicine & Life Sciences 100%
Open Angle Glaucoma Medicine & Life Sciences 25%
Consultants Medicine & Life Sciences 15%
Blister Medicine & Life Sciences 15%
National Health Programs Medicine & Life Sciences 15%
Choroidal Effusions Medicine & Life Sciences 10%
Hyphema Medicine & Life Sciences 10%
Patient Advocacy Medicine & Life Sciences 9%
Edmunds, B., Thompson, J. R., Salmon, J. F., & Wormald, R. P. (2002). The National Survey of Trabeculectomy. III. Early and late complications. Eye, 16(3), 297-303. https://doi.org/10.1038/sj.eye.6700148
The National Survey of Trabeculectomy. III. Early and late complications. / Edmunds, B.; Thompson, J. R.; Salmon, J. F. et al.
In: Eye, Vol. 16, No. 3, 2002, p. 297-303.
Edmunds, B, Thompson, JR, Salmon, JF & Wormald, RP 2002, 'The National Survey of Trabeculectomy. III. Early and late complications', Eye, vol. 16, no. 3, pp. 297-303. https://doi.org/10.1038/sj.eye.6700148
Edmunds B, Thompson JR, Salmon JF, Wormald RP. The National Survey of Trabeculectomy. III. Early and late complications. Eye. 2002;16(3):297-303. doi: 10.1038/sj.eye.6700148
Edmunds, B. ; Thompson, J. R. ; Salmon, J. F. et al. / The National Survey of Trabeculectomy. III. Early and late complications. In: Eye. 2002 ; Vol. 16, No. 3. pp. 297-303.
@article{cd76fc451a384675ba4d0b47361d6315,
title = "The National Survey of Trabeculectomy. III. Early and late complications",
abstract = "Purpose There is a considerable body of literature relating to trabeculectomy, however there are no data representative of the national experience of trabeculectomy in the United Kingdom (UK). The Department of Health funded a national survey of trabeculectomy to establish current practice patterns and the outcome of trabeculectomy in the National Health Service (NHS). In this paper we present the reported complications of first-time trabeculectomy from a nationally representative cohort of patients with chronic open angle glaucoma. Methods Cross-sectional study of consultant ophthalmologists performing trabeculectomy in the NHS. Participants recruited their four most recent consecutive first-time trabeculectomy cases with chronic open angle glaucoma according to study eligibility criteria and data were collected by self-administered questionnaire. Follow-up: one year post-trabeculectomy. Main outcome measures: occurrence of early and late complications. Results: Clinical outcome data were available for 1240 (85.3%) of cases. Early complications were reported in 578 (46.6%) cases and late complications in 512 (42.3%) cases. Some cases had more than one complication. The most frequent early complications were hyphaema (n = 304, 24.6%), shallow anterior chamber (n = 296, 23.9%), hypotony (n = 296, 24.3%), wound leak (n = 216, 17.8%) and choroidal detachment (n = 175, 14.1%). The most frequent late complications were cataract (n = 251, 20.2%), visual loss (n = 230, 18.8%) and encapsulated bleb (n = 42, 3.4%). The occurrence of most complications was not associated with a consultant's specialist interest, level of activity, type of hospital or region. Encapsulated bleb was reported more frequently in a university hospital setting. Conclusions The complication rates reported in this paper represent the national experience of first-time trabeculectomy for open angle glaucoma in the UK. These are similar to previous published studies and highlight in particular, the impact of trabeculectomy on visual acuity in the first year following surgery. This survey provides valid and clinically relevant data on the complications of trabeculectomy for the production of guidelines and standards for audit at regional, local and individual level.",
keywords = "Complications, National survey, Outcomes, Trabeculectomy, Visual loss",
author = "B. Edmunds and Thompson, {J. R.} and Salmon, {J. F.} and Wormald, {R. P.}",
doi = "10.1038/sj.eye.6700148",
journal = "Transactions of the Ophthalmological Societies of the United Kingdom",
T1 - The National Survey of Trabeculectomy. III. Early and late complications
AU - Edmunds, B.
AU - Thompson, J. R.
AU - Salmon, J. F.
AU - Wormald, R. P.
N2 - Purpose There is a considerable body of literature relating to trabeculectomy, however there are no data representative of the national experience of trabeculectomy in the United Kingdom (UK). The Department of Health funded a national survey of trabeculectomy to establish current practice patterns and the outcome of trabeculectomy in the National Health Service (NHS). In this paper we present the reported complications of first-time trabeculectomy from a nationally representative cohort of patients with chronic open angle glaucoma. Methods Cross-sectional study of consultant ophthalmologists performing trabeculectomy in the NHS. Participants recruited their four most recent consecutive first-time trabeculectomy cases with chronic open angle glaucoma according to study eligibility criteria and data were collected by self-administered questionnaire. Follow-up: one year post-trabeculectomy. Main outcome measures: occurrence of early and late complications. Results: Clinical outcome data were available for 1240 (85.3%) of cases. Early complications were reported in 578 (46.6%) cases and late complications in 512 (42.3%) cases. Some cases had more than one complication. The most frequent early complications were hyphaema (n = 304, 24.6%), shallow anterior chamber (n = 296, 23.9%), hypotony (n = 296, 24.3%), wound leak (n = 216, 17.8%) and choroidal detachment (n = 175, 14.1%). The most frequent late complications were cataract (n = 251, 20.2%), visual loss (n = 230, 18.8%) and encapsulated bleb (n = 42, 3.4%). The occurrence of most complications was not associated with a consultant's specialist interest, level of activity, type of hospital or region. Encapsulated bleb was reported more frequently in a university hospital setting. Conclusions The complication rates reported in this paper represent the national experience of first-time trabeculectomy for open angle glaucoma in the UK. These are similar to previous published studies and highlight in particular, the impact of trabeculectomy on visual acuity in the first year following surgery. This survey provides valid and clinically relevant data on the complications of trabeculectomy for the production of guidelines and standards for audit at regional, local and individual level.
AB - Purpose There is a considerable body of literature relating to trabeculectomy, however there are no data representative of the national experience of trabeculectomy in the United Kingdom (UK). The Department of Health funded a national survey of trabeculectomy to establish current practice patterns and the outcome of trabeculectomy in the National Health Service (NHS). In this paper we present the reported complications of first-time trabeculectomy from a nationally representative cohort of patients with chronic open angle glaucoma. Methods Cross-sectional study of consultant ophthalmologists performing trabeculectomy in the NHS. Participants recruited their four most recent consecutive first-time trabeculectomy cases with chronic open angle glaucoma according to study eligibility criteria and data were collected by self-administered questionnaire. Follow-up: one year post-trabeculectomy. Main outcome measures: occurrence of early and late complications. Results: Clinical outcome data were available for 1240 (85.3%) of cases. Early complications were reported in 578 (46.6%) cases and late complications in 512 (42.3%) cases. Some cases had more than one complication. The most frequent early complications were hyphaema (n = 304, 24.6%), shallow anterior chamber (n = 296, 23.9%), hypotony (n = 296, 24.3%), wound leak (n = 216, 17.8%) and choroidal detachment (n = 175, 14.1%). The most frequent late complications were cataract (n = 251, 20.2%), visual loss (n = 230, 18.8%) and encapsulated bleb (n = 42, 3.4%). The occurrence of most complications was not associated with a consultant's specialist interest, level of activity, type of hospital or region. Encapsulated bleb was reported more frequently in a university hospital setting. Conclusions The complication rates reported in this paper represent the national experience of first-time trabeculectomy for open angle glaucoma in the UK. These are similar to previous published studies and highlight in particular, the impact of trabeculectomy on visual acuity in the first year following surgery. This survey provides valid and clinically relevant data on the complications of trabeculectomy for the production of guidelines and standards for audit at regional, local and individual level.
KW - Complications
KW - National survey
KW - Outcomes
KW - Trabeculectomy
KW - Visual loss
U2 - 10.1038/sj.eye.6700148
DO - 10.1038/sj.eye.6700148
JO - Transactions of the Ophthalmological Societies of the United Kingdom
JF - Transactions of the Ophthalmological Societies of the United Kingdom


I came across a beautiful example of activating a student in a progress-focused manner.
Tina teaches high school students in a special boarding school. During the brief period (usually several months) in which these students are at the boarding school they work independently on their subjects most of the time and whenever they need some help or explanation Tina and their colleagues provide it to them. Of course, every now and then the students also have to take tests. Tina frequently uses progress-focused principles and techniques such as growth mindset interventions and autonomy supportive interventions. Every day, she writes brief observation/reflection diary entries, both for her own purpose and to inform her colleagues about what happened on that day. I have read and remembered one of the recent entries in that diary. I went something like this.
Yesterday, I saw that Laura did not work most of the time during class. Most of the time, she just sat there and stared. After class was over I walked up to her. First I said to her that I had the impression that, during this lesson, she hadn't yet been able to get to work in a pleasurable way and I asked her if that was true. She said it was true. I asked her whether she was satisfied about how she had spent the time to which she replied that she wasn't. Then I asked her if she had any ideas about how it might be better next time so that she would be more satisfied. She thought about that for a bit and said she no ideas. Then I asked her: "Might it be a good idea if we'd make a planning together to help you get started?" (She found that a good idea. We spend 5 to 10 minutes making that planing. I have mainly asked questions because I wanted that it would be her who would make the planning as much as possible. Those were questions like: Do you already know what you need to do? How much time do you need for that? What would you like to start with? How would like to work at this?) Today, I was curious how Laura would spend her time. She worked hard all the time. Afterwards, I walked by her and asked her: "I believe that it went well today, right?" She smiled and said that she was satisfied, indeed.
I like Tina's approach in several ways. What has worked well, I think, is the tentative tone in which she shared her observations with Laura. By avoiding a strict and judgmental tone of voice, she did not evoke any resistance in Laura. Then, she was able to activate Laura by asking questions about how satisfied she was and what her own ideas were about how it might become better. She then suggested to make a planning in an inviting manner. While making the planning she activated Laura so that she would feel it was her own planning. I can imagine that this worked pleasantly and well.


text:
Квадратні матриці  називаються конгруентними, якщо існує невироджена матриця , що виконується :

 Відношення конгруентності матриць є відношенням еквівалентності.

Конгруентні матриці виникають під час зміни базису білінійної форми чи квадратичної форми. Дві матриці є конгруентними тоді і тільки тоді, коли вони описують одну і ту ж білінійну форму в різних базисах.

Перехід від одного базису до іншого задається матрицею переходу

Закон інерції Сильвестра

Щоб спростити задання білінійної форми, шукають базис в якому її матриця є діагональною.

Довільна дійсна симетрична матриця є конгруентною до деякої діагональної матриці, при чому, можна обмежитись тільки ортогональними перетвореннями

І діагональна матриця буде складатись з власних значень матриці  (див. Подібні матриці).

Якщо ж не обмежуватись тільки ортогональними перетвореннями, то можна добитись, що на діагоналі будуть тільки числа -1, 0, +1.

Закон інерції Сильвестра стверджує, що дві дійсні симетричні матриці конгруентні тоді і тільки тоді, коли в них однакова кількість додатних, від'ємних і нульових власних значень.

Дивись також
 Теорія матриць

Джерела

Типи матриць
Еквівалентність (математика)

redpajama_set_name: RedPajamaWikipedia


ΣyG - FDI - Future Designs Inc.
∑yG is the sum of high-quality products that provide a robust and proven source for GUI and HMI solutions.
The Future Designs, Inc. ΣyG Family provides a complete and qualified platform for the rapid release of Renesas Synergy-based embedded touch screen display products. The core of ΣyG (pronounced, "Sig") is Renesas Synergy – a comprehensive and integrated software-based microcontroller platform.
ΣyG products are carefully designed by the same team of engineers who earned FDI's recognition as a Renesas Independent Design House, Platinum Alliance Partner, and Certified Training Center. This, in combination with our expertise in GUI and HMI hardware, touch screen systems and cost effective, volume production, results in FDI's ability to offer a high-quality family of Renesas Synergy-based products. Additionally, our products utilize a compact, integrated, interoperable, secure and easy-to-use embedded wireless stack shortening our customers time-to-market for applications implementing low-cost and low-power wireless connectivity. ΣyG is the smart choice for customers interested in developing a project with Renesas Synergy or searching for a complete, fully-equipped, standalone embedded display solution.
ΣyG is FDI's family of Renesas Synergy-based GUI products. ΣyG products provide a complete hardware and software solution for developing embedded display projects. ΣyG products feature the Renesas Synergy software and microcontrollers for a complete and qualified development platform.
FDI released its ΣyG product family in October 2015 in conjunction with the biannual Renesas Devcon event as the first partner to have S7G2-based GUI products in distribution stock. FDI is uniquely qualified to provide Renesas Synergy GUI products as a Reneas Gold Alliance Partner, Renesas Independent Design House and Certified Training Center.
2. How is ΣyG pronounced?
3. What's the difference between ΣyG and μEZ® GUI?
ΣyG features Renesas Electronics' proprietary hardware and software, Renesas SynergyTM. Synergy is a comprehensive, integrated platform designed to bring complex system designs to market fast.
Like μEZ GUI, ΣyG products include all the hardware, software and technical resources needed to develop high-value embedded designs with quick time-to-market. Unlike μEZ GUI, ΣyG products are optimized for customers who have a preference for developing with Renesas Synergy versus our FreeRTOS-based μEZ® software.
4. Why should I develop with Renesas Synergy?
5. When will off-the-shelf ΣyG GUI products become available?
The priority and release schedules for FDI's ΣyG GUI products is still being defined. FDI is working with a number of key customers to drive this effort. Preference will be considered for customers interested in providing direct influence to the feature set and details and will benefit by receiving end products that are optimized for their application.
If you are interested in partnering with FDI on the development of standard off-the-shelf ΣyG GUI products for your application please contact us at Sales@TeamFDI.com .
6. I need help deciding which product family is best for my design. How do I decide?
If, after review the above chart, you still have questions about which standard product family is best suited for your requirements, contact Sales@TeamFDI.com and a member of our team will reach out with 24 hours.
The Team at FDI is here to help you bring your project plan together.
In this section we will provide guides, tip sheets and application notes to assist you with ΣyG project development. Please reference this area frequently as it will be updated regularly with new information.
If you have lingering questions or suggestions for topics that could be addressed please contact a member of our technical team by email at Support@TeamFDI.com.
Team FDI works to keep the Application Notes on the current version of the Renesas Synergy SSP. If you find that you need an updated version please contact a member of our technical team by email at Support@TeamFDI.com.


A match between Patrick Cote and Alessio Sakara has been booked in the middleweight division at UFC 154.
UFC officials announced the match-up on Friday.
Cote (17-8) made his return to the octagon at UFC 148, where he lost a decision to Cung Le. Cote has not won a fight inside the octagon since 2008, however he is 13-0 outside the organization.
Sakara (15-9) has lost his last two fights inside the cage. He lost to Brian Stann and Chris Weidman. He will look to regain steam with a win over Cote at UFC 154.
UFC 154 is set to go down on November 17 at the Bell Center in Montreal, Canada. The main event is un-officially a welterweight title unification bout between Georges St-Pierre and interim champ Carlos Condit.


That's it! & I won't find out any more than that until we arrive at the airport. Or at least hopefully airport, unless we really are going to Butlins!!
Just as Mauritius was where Seb's been gunning for from the start, the Maldives would have been my choice. Although slightly put off by the fact that Seb's family went on a random holiday there recently, I've always wanted to go. Ever since studying it in Geography, it's on my bucket list before it disappears! Saying that, my idea of a honeymoon in Mauritius is a little shack out in the sea with a private infinity pool and a glass floor to see the fish & I'm not sure our budget *quite* stretches to that!
A fairly rogue choice, I think, but it's come up in conversation before and I once got told by a local at the pub I worked in that I would absolutely love Southern India. It's not really a place I know much about except for being told that it's beautiful & amazing, so the idea has kind of stuck! I think it's definitely got more culture than say, the Maldives, but I'm not sure if that's what Seb would go for. He'd definitely be tempted by the idea of authentic Indian cuisine though!!
Some may say Seb's mad for taking this responsibility into his hands. I must say, I agree! But it doesn't half add some excitement for me – I bloomin' love surprises!! & I can't wait to see if any of my guesses are right!
Where do you think we're going?


text:
Woman and teenage boy killed in crash that closed Lancashire motorway
LP Reporter
A woman and a teenage boy have died in a crash that has closed a major Lancashire motorway for most of the day.
A 31-year-old lorry driver from Chorley has been arrested on suspicion of causing death by dangerous driving after the crash on the M58 this morning.
The crash happened at about 9am today
The crash, between junctions 3 and 4 of the westbound carriageway, happened at about 9am today and involved an HGV, a minibus and a number of other vehicles.
A woman and a 14-year-old boy suffered injuries which later proved fatal, and several other people have been hospitalised.
READ MORE: Traffic diverted to M6 as full closure of motorway continues
The driver of the HGV, a 31 year old man from Chorley, was arrested on suspicion of causing death by dangerous driving and is currently in custody.
Shortly after the initial collision a second collision took place involving an HGV, a van and a car. As a result of this collision a woman also suffered serious injuries. Two men were also seriously injured.
The motorway has been closed in both directions all day, and is likely to remain shut until this evening.
Images from the scene showed a lorry carrying scaffolding material and a number of badly damaged cars.
The lorry transporting the scaffolding belongs to a Preston firm based at Red Scar Industrial Estate in Longridge Road.
A spokesman for Allied Scaffolding said: "We are fully aware of the situation and it is related to our company. "We are in full co-operation with the police and authorities and will give them our full support.
"Our main concern at this stage is for those involved in the crash."
A fleet of emergency services vehicles descended on the carriageway to deal with the emergency.
Two air ambulances, four land ambulances, police and fire engines are all in attendance following the crashes.
Highways England are warning that the M58 is likely to remain closed until late afternoon.
Police are urging people to avoid the area as the closure continues to impact Lancashire's motorway network.
A Lancashire Police spokesman said: "Our thoughts are with all of those affected by today's tragic incidents. Anyone who is concerned that someone they know may have been involved and who needs to speak to police should call 101 quoting log number 0523 of today, January 8."


text:
Vatican fires gay priest on eve of Catholic bishops meeting
Yamiche Alcindor
The Vatican fired a priest Saturday after he came out as gay and revealed he has a boyfriend on the eve of an important meeting of the world's bishops to discuss church teachings on family life, a topic that encompasses divorce, homosexuality and cohabitation.
Considered a high-ranking Vatican official, Monsignor Krzysztof Charamsa, 43, lived in Rome for the last 17 years and worked at the Congregation for the Doctrine of the Faith since 2003.
In several interviews, Charamsa said he was happy and proud to be a gay priest, and was in love with a man whom he identified as his boyfriend, according to the Associated Press. He said he wanted to challenge the church's "backwards" attitude to homosexuality, the BBC reported.
"It's time the church opened its eyes and realized that offering gay believers total abstinence from a life of love is inhuman," he said, according to the network.
Charamsa also said he knew he would have to give up his ministry but felt he had a duty toward sexual minorities to come out, BBC reported.
In addition to Davis, pope met with gay couple in Washington
The Vatican reacted quickly by firing him and criticizing the timing of his revelations. On Sunday, Pope Francis formally opens the global meeting, known as a synod, where some 270 bishops from around the world will discuss church doctrine.
"The decision to make such a pointed statement on the eve of the opening of the synod appears very serious and irresponsible, since it aims to subject the synod assembly to undue media pressure," Vatican spokesman Federico Lombardi said in a statement.
Charamsa can no longer work at the Vatican or its pontifical universities, Lombardi said. However, Charamsa remains a priest though Lombardi said further actions could follow.
Intense jockeying on gay issues precedes next week's Catholic synod meeting
In the 1960s, following the reforms of the historic Second Vatican Council (1962-1965), Pope Paul VI established a synod system so that bishops from around the world could meet every few years and continue to foster a more collegial, collaborative and horizontal form of church governance.
It was designed to reduce the centralization of power in the Roman Curia, the papal bureaucracy, and allow input from bishops with pastoral experiences from different countries. The status of gay Catholics is among the most fiercely debated.
No rest for a weary pope: Back in Rome, Francis faces a bigger test than U.S. trip
Charamsa held a press conference in central Rome after the Vatican's actions. He was joined by his companion, identified only as Eduard. Charamsa told reporters that the timing of his disclosure was not related to the bishops meeting on the family, but said he hoped it might add "a Christian voice" to the meeting, AP reported.
"I came out," Charamsa said. "This is a very personal, difficult and tough decision in the Catholic church's homophobic world."
Contributing: Religion News Service


text:
Q: Reading data-only from Wacom tablet Is there any way to read data from Wacom tablet without raising mouse-events on Linux?
I'm now using Ubuntu 12.04 LTS and Wacom Intuos 5.  It's OK to use the tablet on Ubuntu and I'm using tablet via Ggtkmm3.0. But I would like to get ONLY the tablet's axis data without binding to the window. Gtkmm's window can get tablet-event but I think it is not periodic because it's event-driven.

A: Using Linux Input Subsystem will be available to take your task.
The code is here, this is print out cordinate (X, Y) and pressure. (for example, filename is lis_read.c)
#include <stdio.h>
#include <stdlib.h>
#include <linux/input.h>
#include <unistd.h>

int main (int argc, char *argv[]) {
    struct input_event event;

    for (;;) {
        if (read(0, &event, sizeof(event)) != sizeof(event)) {
            exit(EXIT_FAILURE);
        }

        switch(event.type) {
        case EV_ABS:
            switch (event.code) {
            case ABS_X:
                printf("ABS_X: %d\n", event.value);
                break;
            case ABS_Y:
                printf("ABS_Y: %d\n", event.value);
                break;
            case ABS_PRESSURE:
                printf("ABS_PRESSURE: %d\n", event.value);
                break;
            default:
                break;
            }
            break;
        }
    }

    return EXIT_SUCCESS;
}

You can build this:
% gcc -o lis_read lis_read.c

If your pentablet device path is /dev/input/event7, then this program usage is:
% ./lis_read < /dev/input/event7

Root permission will be needed this program.


A 3 year old and a 1 year old oh my!
Well I loaded all the pictures backwards because that's what I used to have to do w/ Blogger to get them to appear correctly but apparently they fixed that so these go from the end to the beginning. . .
This is how Ty's birthday party ended--he was pooped!
He loved his new car from mom and dad--his sister and cousin loved it too!
Mom and Dad with the big birthday boy.
Ty was so cute with his cake. He leaned down and took bites with no hands most of the time.
The cake was made by Amy, my sister in law---we love Amy Cakes! The block letters were a gift from Leah at one of my baby showers. I thought they looked cute by the cake.
Ty had to get his hair cut for the first time before his big day. He did really good and looks so dang cute w/ his short hair. My little man!
Abigail Kristine celebrated her 3rd birthday on November 6th, just a week before Ty. Ty and Abs had been sick w/ the flu just days before her birthday and then I got it ON her birthday so our celebration that night was a bust. We did celebrate the next night by taking Abs out to Red Robin--her fave place to eat because she gets quarters and wins candy! Abby is all about Cars and Toy Story this year. She is getting quite an imagination and I love sitting back and watching her play. Her favorite foods are cucumbers (the girl could eat an entire cucumber!), popcorn, ice cream (she sometimes cons me into letting her have it for breakfast) and they both love steak! HA She is the most polite little girl I know, saying "thank you Mom" and please, excuse me and God bless you. She is quite the talker all.the.time! I love the things she says. I can't even believe she is three years old! She is pretty much out of the terrible twos and only has fits here and again. . .for the most part she wakes up happy and goes to bed happy. Today she woke up and crawled into our room acting like a puppy. Hilarious!
So Abs got to celebrate her birthday with her friends at preschool on her actual birthday--I made cupcakes (right before I got sick-thank Goodness) for her to take to school, then she got to go to Red Robin the next night, celebrate w/ some family at Chuck E Cheese on Saturday and end w/ the Fresh Beat Band Concert! She had a wonderful week of celebrating. I love you sweet girl--Happy 3rd Birthday!
Here we are at Chuck E Cheese--Griffin pretty much just drove this the ENTIRE time. He loves anything "workin man"!
We discovered that Ty loves anything with a steering wheel. He had a great time on the rides too.
Could this not be the sweetest pic ever? Cousin Sophes kissing the birthday girl!
All the gals headed out to the Fresh Beats! Abby and Sophia LOVED the concert.
The mini cupcakes I made for preschool. Cherry Chip w/ pink frosting--my fave. . .so I was hoping it would become Abby's fave too but she's more of an ice cream gal like her Dad.
Grandma and Grandpa got Abs a new trampoline since she loves to jump and she is on that thing all.the.time! She will watch TV while jumping. . .poor girl is gonna lose weight if she's not careful. Ty also loves this thing. He sits on his knees and jumps and laughs so hard. It's hilarious but also a lot of work because I have to make sure he doesn't fall off.
Now on to Daddy's birthday on Monday--November is the Birthday month at the Wyckoff home!!
A few weekends ago the fam decided to take advantage of the beautiful weather and head to the pumpkin patch. Normally we go to the Fall City Pumpkin Patch but this year we drove past Remlinger Farms and Zach asked if we should try it out. . .what a GREAT decision it was! We had the MOST fun enjoying not only the pumpkins but also their Fall Harvest Festival which included a petting zoo, food and rides for the kiddos.
Abby got to ride her first pony! She was so excited and had a perma-grin the whole time!
Ty rode his first pony too. . .a plastic pony--he too, had a perma grin the whole time!
We all got to ride on a steam engine train around the entire farm--so, so cool!
The kids got to climb on an old fire truck and Abs even drove it.
Speaking of driving. . .both Abs and Ty got to drive Mom and Dad around in an old car.
Nearing nap time. . .
but first a hayride out to the pumpkins! Abby loved this so much that we had to do it a few times.
Ty loved that we finally let him out of the Ergo! Check out his hair flying in the wind. He was in heaven.
. . .has come and gone so quickly! I can't believe it's over. I have been a horrible blogger and feel terrible about it since this is pretty much baby books for both my babes. September was such a beautiful and busy month. Here is a quick picture recap of the month.
Driving around in the morning makes for a weird schedule every once in awhile and this particular day Ty did not want to lay down for a nap so I stuck him in the jump up and he finally fell asleep!
A fun grocery shopping trip to Safeway. . .Abby loves the cart w/ the car because she has the option of driving us around OR sitting next to her brother. She also knows they have complimentary cookies in the bakery so that is always our first stop!
Even though she loves her cookies, she is good about brushing her teeth and getting the "sugar buggies" clean. Her first dentist appointment went so well. She let them do everything without a fuss--she was so excited!
All the Hussey girls went to see Tim McGraw. Grandpa watched my babes since Zach was in Germany and when we got home it was hilarious. Abs was awake standing in the window of her room under the blinds saying "big red truck is back" all while there was a huge poo in her diaper. Ty was crying his head off and my dad was snoring in his room with the baby monitor sitting on the kitchen counter because he thought we'd want to see the kids when we got home. . .well, we saw them alright! Hee hee, both went back to sleep in no time. It still makes me laugh.
Our bigga boy is taking steps but he gets so excited to get to the person he is stepping to that he can only take a few steps and then lunges towards us. We're wondering if he'll be fully walking by his first birthday. . .we'll see!
Our bigga girl just keeps growing. . .right out of her jammies! :) She is so adorable right now saying and doing so much. She amazes me every day with her vocabulary, sentences, counting, alphabet, sense of humor, dancing, using her imagination, working on the computer etc. She is a quick learner and LOVES to do everything on her own.
I still can't believe my children are turning 3 and 1 next month. I am excited for their birthdays! Next post--The Pumpkin Patch. . .coming soon. :) Happy Fall everyone!


31 Legacy Players named ALL DAILY PRESS ALL STAR!
The Virginia Legacy woud like to congratulate the 31 players who were recently named to the All Daily Press All-Star teams. 15 of the 19 Boys and 16 of the 19 girls all play their club soccer at Virginia Legacy!
These players were selected for their performance on the field this past spring regardless of their schools classification (3A, 4A, 5A, private etc).
In addition to the 31 players selected below - Legacy's own Erin Gravette was named the Girls Daily Press Player of the Year!
Join us in congratulating the 31 young men and women for being recognized as the top players in the Hampton Roads/Tidewater area and on outstanding high school seasons!
Click here to see the full boys team!
Click here to see the full girls team!


The last time we left the fictional Nike Space Program (NSP) at last year's mid-season basketball weekend in Orlando, our heroes had successfully launched into space on a mission to elevate the game to a greater galaxy.
After a sudden Big Bang in Orlando, it has been months without contact as they disappeared into space. All hope is not lost, as a transmission has just been received at Area 72 — a top-secret facility isolated in the depths of the desert in Houston, Texas, home of this year's mid-season showdown.
Continuing the extraterrestrial design inspiration established in the Nike Basketball collection for Houston, Nike Sportswear presents a top-secret collection of five shoes celebrating the best of basketball. Merging old-school models with new-age innovation, the premium collection includes the Nike Blazer Mid, Nike Vandal, Nike Lunar Force 1, Nike Barkley Posite Max and Nike Air Force Max 2013.
The collection celebrates the legacy of iconic Nike Basketball models of the past, now infused with galactic textures, reflectivity and glow-in-the-dark highlights. Developed deep within Area 72's top-secret testing facility, the five-shoe collection features a custom galaxy print also featured on Nike Basketball's performance shoes for Houston. The print appears on the collar lining of each shoe.
Since making its debut for Nike Basketball more than a decade ago, the Nike Raygun character is reincarnated on the tongue of each of these shoes. With its trademark jetpack and alien physique, the Raygun is ready to strike opponents with fury.
Available 15th of february, 2013 in very limited quantities at CONCRETE.


There are several new provisions tucked into the trillion-dollar spending bill that Congress is set to approve. This is the one that will prevent a government shutdown. And we're going to peel back one of the provisions in the bill. It creates new opportunities for big-dollar fundraising for the Democratic and Republican Parties.
PETER OVERBY, BYLINE: Look at it one way and this change would ease the fundraising rules that have crippled the budgets of the party committees. Look at it another way and it means a donor of sufficient means could give the party establishment about $778,000 each year. That's eight times the current limit. Lisa Gilbert is director of Congress Watch, a division of the liberal advocacy group, Public Citizen.
LISA GILBERT: It, you know, once again empowers the richest and will drown out every-day Americans who want to participate.
OVERBY: The provision goes to the heart of a debate that began a dozen years ago with passage of the last campaign finance overhaul. Back then, liberals wanted to drive corrupting big money out of the political parties. Conservatives said the big money wasn't corrupting and the overhaul drove it to outside groups, which was a bad thing. Then came the Supreme Court's Citizens United ruling and other court decisions, setting off the rush of super PACs and secret money political groups, nearly all of them outside the party organizations.
Ray La Raja is a political scientist at the University of Massachusetts Amherst.
RAY LA RAJA: Groups were getting involved that we didn't know who they were representing, and where were they getting their money. This changes that.
OVERBY: He points out that parties have to disclose their donors, while many outside groups do not. Here's how the new provision works - each party has three committees in Washington - the national committee, Senatorial campaign committee and House campaign committee. Under the new language, each committee can create a building account and a fund for recounts. Each party is also allowed to accept $97,200 a year for its presidential nominating convention. That makes up for public financing for conventions, which Congress killed-off back in March.
La Raja says that now the parties will be able to cover basic infrastructure costs.
LA RAJA: They were playing triage before this.
OVERBY: What Lisa Gilbert and her allies object to is the way the new funds are financed. Each new fund comes with its own contribution limit triple the size of the regular contribution to a party committee. And even despite that, Gilbert says donors to outside groups aren't likely to change their giving patterns.
GILBERT: If we see the more money in the parties, I have no doubt that we will see more money in the independent expenditure states as well. It just increases the arms race, increases the overall amount of money in an already too-monied system.
OVERBY: Now Public Citizen and other pro-regulation groups are urging members of Congress to vote no on the whole bill, and so are some conservatives. They see the provision as an attempt to fortify the Republican establishment against intraparty challengers.


We supply rare movie titles that are not COMMERCIALLY available or out of print on DVD that are no longer available through retailers. All of our titles are encoded Region 0, suitable and playable worldwide. We acquire all our rare titles directly from our inside studio contacts within the film industry archives and occasionally from major private film collectors here and abroad. Our Movie Manufactured By Demand,and movie search service is intended for Serious Movie collectors who are in search for rare movie titles that never had a dvd released in the U.S. or out-of-print dvd released titles that cannot be found through retailers anymore.
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released "Sparkle and Fade" in 1995. Check out their new project "The Vegas Years"... HERE.
Released on Portland's Tim/Kerr label, this project was actually recorded in a friends house basement. Click To Buy It!
Everclear parted ways with drummer Cuthbert, brought in Ecklund and signed with Capitol Records. CLICK TO: Download Now or Buy CD!
Features the bands heavier side, even their top hits come across with more volume. Click To Buy It!
A collection of demos mostly recorded with drummer Scott Cuthbert in 1994 in preparation for Sparkle and Fade. Click To Buy It!
The band changed labels, but Capitol owns the rights to all material released on Capitol. Click To Buy It!


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I had always wanted to be in the interior design space however, I thought it would be more lucrative to be trained as a graphic designer. After many years in corporate life, I needed to do something for me.
Researching the available courses, I decided The Professional Interior Design Course offered by The Interior Design Academy wrapped up the theory and processes in the areas I wanted training and delivered a course in a flexible format that suited my full-time employment and home commitments.
The course was practical and challenging with each unit built on the learnings of the last. It gave me confidence in this space, and, by the end, I had a portfolio that was relevant and a series of document templates that have been so useful in the "real world" – I haven't looked back.
Now armed with renewed confidence, passion and new skills, I resigned from my job, styled our Sydney home, sold it for a record price in the street, and made the sea-change dream a reality.
What I didn't factor in was that people living in small Australian coastal towns 5 years ago were not ready to invest in styling, nor design consultants to help with their home renovations.
Undeterred, I decided this was an opportunity to go-it-alone and build on my limited portfolio!
So, I began flipping houses. It took a while to understand the local market, buy a house ripe for my yet-to-be tested skills, develop a professional and reliable tradie team, and then work out what I was doing.
After selecting a house, I consulted my course notes again. Following the process I was taught, I designed and scoped the improvements to my tight budget, only making improvements that would maximise my profit. After discussing my plans with my team and listening closely to their feedback, I would then work alongside them as their "TA" (tradies assistant) so I could add practicality to my design approach – or in their words – learn from my mistakes.
Each time I have tried to select a house that was different from the last one, and so the theming/design would need to be different to ensure that my learning curve is steep and my portfolio now more diverse.
Five years on, I am thinking of expanding into consultancy projects with my website being developed but I am not going to push into it hard just yet as I am still loving the thrill of the "flip". The reality is however, what happens when I can't run up and down ladders anymore?
I have just started on my fifth design challenge. This will be my first two storey – a really ugly, brick house. I plan to turn it into a home by the end of the year and then flog it and start the next. I am not sure what comes after a Californian Bungalow, a 1920s seaside cottage, a garage conversion, an old 2 bed/1bath apartment (I haven't sold that), a 60s double brick monstrosity, and now a brick veneer double story… Only time and my hunger for challenges will tell!
The training I undertook through The Interior Design Academy was the perfect foundation to launch myself out of the confines of corporate into the wonderful world of colour, form, furnishings, and fabulous tradies!


Sajani Philip, MBA professional working with MNC in Bangalore. Her interest include listening to music, travelling, reading etc. A fun loving, caring, God fearing, family oriented person, true believer of Jesus and Born Again Believer and baptized. Accepted Jesus as her personal savior and seeking his will in her life, seeking him more and more.Looking for guy who is born again and baptized and seeking Christ as his first priority and loves Jesus from his heart.
We were in Dubai till 1998. Sajani and her sister studied in dubai.Her sister is now married and residing in Canada. Brother is working in Dubai. Now we are settled in Tiruvalla.


PHP Development Team is proud to announce the release of PHP PHP 4.3.6. This is is a bug fix release whose primary goal is to address two bugs which may result in crashes in PHP builds with thread-safety enabled. All users of PHP in a threaded environment (Windows) are strongly encouraged to upgrade to this release.
Updated bundled PDFLib library to version 5.0.3p1 in Windows distribution.
Synchronized bundled GD library with GD 2.0.22.
Fixed bugs that prevented building of the GD extension against the external GD library versions 1.2-1.8.
Fixed a bugs resulting in leakage of session settings across requests.
Fixed several daylight savings bugs inside the mktime and strtotime functions.
Fixed a number of crashes inside domxml and mssql extensions.
All in all this release fixes approximately 25 bugs that have been discovered since the 4.3.5 release.
For a full list of changes in PHP 4.3.6, see the ChangeLog.


James Brooks was previously Science Editor and then Genetics Editor at BioNews and at the charity that publishes it, the Progress Educational Trust (PET). He is also Assistant Editor of Funding Insight and a reporter covering French news for Research Europe, both published by Research Professional. He began his career in journalism as a reporter for HR Grapevine Magazine, and has written for publications including the Guardian newspaper and the British Medical Journal. Previously, he studied Pharmacology at King 's College London and went on to obtain an MA in Science Journalism from City University London, where he received a commendation for most creative graduate. During his undergraduate degree, he took an extramural year at the Institut Gustave-Roussy cancer research centre, where he researched DNA topoisomerases. Before working in journalism, he spent seven years in Paris working at Euromedica and CTPartners (now part of DHR International), as a headhunter for the pharmaceutical industry.


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