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IPC Athletics World Championships
EVENT SCHEDULE/RESULTS
INFORMATION FOR TEAMS
OFFICIA RESULTS BOOK
Teams start arriving for Lyon 2013
Eighty-six of the 98 countires competing at the 2013 IPC Athletics World Championships will arrive in the city on Monday (15 July). 15 Jul 2013
Brazil had a clean sweep of the women's 100m T11 final at London 2012, which was won by Terezinha Guilhermina in a new world-record time of 12.01.
ⒸGetty Images
By IPC
"Terezinha is aiming to run under 12 seconds for the first time in the 100m, whilst Lucas wants to smash his own 100m world record. He broke it in Berlin, Germany in June but the wind was too high. Hopefully in Lyon the conditions will be perfect."
With just days to go until the start of the 2013 IPC Athletics World Championships in Lyon, the majority of teams will arrive in the French city on Monday (15 July).
According to event organisers 86 of the 98 competing countries will check-in to their bases today, whilst one of the first teams to arrive was Brazil who arrived last Thursday (11 July).
The Brazilians who won 18 track and field medals at London 2012, including eight golds, to finish seventh in the athletics medals table have 35 athletes and 11 guides in Lyon and are aiming for a fifth place finish.
"We arrived on Thursday and the team has settled really well," said Brazilian team manager Ciro Winckler. "On Saturday we managed to take in the finish of the Tour de France and shared the same hotel with Team Sky which was a great experience.
"We have a number of new athletes with us here and this is their first step on the road to the Rio 2016 Paralympic Games.
"Our aim is for some good results with our established visually impaired athletes, but we also have a number of new cerebral palsy athletes who I hope will perform well.
"The likes of established athletes such as Alan Oliveira, Terezinha Guilhermina and Lucas Prado are also here in Lyon targeting gold medals.
The 2013 IPC Athletics World Championships opens this Friday (19 July) and will feature over 1,100 athletes from 98 countries. It is the biggest gathering of international athletes since London 2012 and will be streamed live from Saturday morning via www.ParalympicSport.TV
Live results can be found at the Lyon 2013 IPC Athletics World Championships website whilst updates and behind the scenes pictures can be found at twitter.com/IPCAthletics and facebook.com/IPCAthletics.
2013 IPC Athletics World Championships
World Para Athletics Partners


SAN FRANCISCO, CA – This week, the US Department of Health and Human Services (HHS) appointed A&PI Wellness Center to be a new Federally Qualified Health Center (FQHC), increasing access to the highest-quality primary care, mental health, and supportive services for thousands of LGBTQ San Franciscans, people of color, and people living in the Tenderloin neighborhood.
The competitive award secures approximately $650,000 in annual funding for the organization. A&PI Wellness Center was the only community health center in San Francisco and one of 266 clinics nationwide to achieve FQHC status this year.
A&PI Wellness Center launched its free medical clinic, the Wellness Clinic, in 2011 with an all-volunteer staff and has since expanded through a partnership with University of San Francisco's School of Nursing and Health Professions. The federal recognition raises A&PI Wellness Center to a new level in the healthcare landscape of San Francisco and the US.
Wellness Clinic services include primary medical care, mental health and counseling services, case management, and peer navigation. A&PI Wellness Center's transgender health specialty clinic is integrated into its on-site transgender community drop-in center, TRANS:THRIVE, making it easier to access a wide array of stabilizing services that are the foundation for physical and mental health. The clinic is also the only provider of comprehensive family planning medical services in the Tenderloin area.
For media inquiries, please contact Stephanie Goss at 415-292-3420 ext 330.
Learn more about our medical clinic, the Wellness Clinic.
See a list of FQHC national awardees.
5 Replies to "A&PI WELLNESS CENTER'S LGBTQ MEDICAL CLINIC DESIGNATED A FEDERALLY QUALIFIED HEALTH CENTER"
API Wellness Center rocks! And the Feds know it.
Thanks, Tri! We're lucky to have you leading the charge.
Congratulations on your award. I hope everyone realizes the amount of effort that goes into submitting all the necessary paperwork to qualify for a Federally funded program!
It is especially rewarding to read that you were the only recipient in the San Francisco area.
A job well done, again, congratulations to everyone involved.
Thank you, Michael. We could not have done this without the tireless support of clients, community, and supporters.


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WRPM: Women's Revolutions Per Minute Recordings of music performed, composed and produced by women; an administrative archive of feminist distribution and promotion business.
If no link is given, please ask in Special Collections to view the collection.
The College Publications Collection pamphlets published under the Goldsmiths imprint, inaugural lectures etc.
A selection of items from the Goldsmiths Archive has been digitised, including Annual Reports and Prospectuses of the Art School.


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Nissan nabs rising tennis star Naomi Osaka as new ambassador
Nissan has appointed Naomi Osaka (pictured) as its newest brand ambassador. As part of the deal, Osaka will be appearing in global promotions and advertising for the Japanese car brand. In addition, Nissan will support her activities as a tennis player, including the provision of Nissan vehicles at her tour destinations.
The move comes days after Osaka won her first Grand Slam championship, beating renowned tennis champion Serena Williams. The deal also marks Osaka's first public appearance following the championship.
In a statement, Osaka explained she was drawn to partner with Nissan due to its strong Japanese DNA and global competitive spirit. Osaka is of Japanese-Haitian ethnicity and currently competes for Japan. She added that Nissan as a brand is always challenging expectations and she looks forward to bringing its vision for driving excitement to new audiences around the world.
"This week has been a dream come to life, and I'm so honoured to represent Japan and Nissan on the world stage," Osaka said.
Asako Hoshino, senior vice president at Nissan Motor Co., said that with a "combination of grit and grace", Osaka is not afraid to take on the best tennis players of this time, and win.
"This is the same spirit of performance that Nissan has embodied throughout our history – exemplified most recently by the Nissan LEAF, which defied the odds to become the best-selling electric vehicle in the world. And just like Osaka, Nissan is just getting started," Hoshino added.
NISSAN says, 'My One Better Than Your One'
Renault-Nissan-Mitsubishi Alliance unveils new logo
Nissan names head of marketing and sales for Asia

redpajama_set_name: RedPajamaCommonCrawl


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The letter C: A Glossary of Windows Terms
Windows Platform / By Joli Ballew / Windows Performance Tips and Tweaks, Troubleshooting and User Guides: Getting The Most From Your Windows PC
Cable modem – the hardware used to transmit data to and from the Internet. Cable modems connect to the cable TV connection in a home or office.
Cache – an area in the computer where information is stored temporarily.
Card Reader – a generic term for any hardware than can read SD cards or other types of flash memory.
Cat 5 (Cat 6) – an Ethernet cable standard for twisted pair Ethernet.
Central Processing Unit (CPU) – a computers "brain" so to speak. The CPU processes information and basic instructions, as well as performing complex calculations.
Certificate – in computer terms, a file that identifies as web site as "secure" and legitimate.
Chrome – Google's web browser.
Clipboard – a section of temporary storage where information is stored that is copied or cut from a document or folder. It can also be a selection of an image, among other things. Users often use Copy or Cut commands to save the data to the clipboard, and then use Paste to insert it somewhere else.
CMOS – Complimentary Metal Oxide Semiconductor. In computers, the CMOS battery offers the power needed to store the date and time, among other things, even when the computer is turned off.
Coaxial Cable – a cable used for transmitting telephone and television signals. For the home user, it's what connects the cable modem to the cable outlet in the wall.
Codec – short for coder-decoder, a compression technology used with digital media. MPEG, AVI, WAV, and AIFF are codecs.
Compression – a way to make files take up less space. Vista and XP both come with a compression utility, and there are third party compression utilities available, like WinZip.
Control Panel – a feature of all Windows-based operating systems where users can modify settings and configure preferences.
Cookies – information stored in a text file on your computer placed there by a web site to keep track of your name, preferences, and other data. Cookies from trusted sites are almost always harmless.
Crossover cable – a cable used to temporarily connect two devices of the same type to each other using Ethernet ports.
Crossplatform – software that can run on multiple computer systems. For instance, Microsoft Word can be run on both Windows and Mac computers.
Cyberspace – usually refers to the Internet and is a generic, slang, term.
This post is part of the series: Windows Glossary
Learn the definitions for the terms used in the Bright Hub Windows Channel. This series starts with the letter "A" and runs all the way to "Z".
A Glossary of Windows Terms – "A"
A Glossary of Windows Terms – "B"
A Glossary of Windows Terms – "C"
A Glossary of Windows Terms – "D"
A Glossary of Windows Terms – "E"
A Glossary of Windows Terms – "F"
A Glossary of Windows Terms – "G"
A Glossary of Windows Terms – "H"
A Glossary of Windows Terms – "I"
A Glossary of Windows Terms – "J" and "K"
A Glossary of Windows Terms – "L"
A Glossary of Windows Terms – "M"
A Glossary of Windows Terms – "N"
A Glossary of Windows Terms – "O"
A Glossary of Windows Terms – "P"
A Glossary of Windows Terms – "Q"
A Glossary of Windows Terms – "R"
A Glossary of Windows Terms – "S"
A Glossary of Windows Terms – "U and V"
A Glossary of Windows Terms – "W"
A Glossary of Windows Terms – "X", "Y", and "Z"
Using Android Cortana to Enable Alerts in Windows 10
How to Install and Use Linux Bash on Windows 10
Windows 10 Celebrates with Anniversary Update
Microsoft HoloLens for Everyone? Exploring the Windows 10 Holographic Shell
Microsoft Paid How Much for LinkedIn?
Government Sued by Microsoft over Notification Concerns


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Mid-session Paris: Carre...
A triple settling of sco...
a car rushes towards the...
Paris opening: doped Car...
Open lists and the abolition of a mazhoritarka. As elections will be held under the new electoral code
magictr | December 19, 2019 | Politic | No Comments
The electoral code, adopted today, taking into account proposals of President Vladimir Zelensky, brings a number of innovations in the electoral system.
A document published on the Council website, introduces in Ukraine the proportional electoral system with open regional lists. Ukrainians will vote both for the party and for a particular candidate in the list of political forces.
The code abolishes the vote for the Parliament in single-mandate constituencies. The party will propose a national list of candidates. The first nine will remain in it, and the rest is distributed via the regional lists, which should be from five to 17 people.
The constituency has remained the same is region of Ukraine. While Kiev will be divided into two districts – the left and right banks, and the latest to join another foreign County. Share will and Dnipropetrovsk oblast – Dnepropetrovsk and Krivoy Rog district. Thus, Kherson region, Crimea and Sevastopol will join the southern district.
At the same time, the code removed the ability to remove a candidate from the race after the law enforcement officers sent information about it to the Central election Commission for violation of the law.
In addition, when forming party lists poltically now must be respected gender balance: in each of the five candidates should be at least two people of each sex.
Recall that of the electoral code ruled out the possibility of the withdrawal of candidates from the election by the letter of the SBU.
Also "Country" wrote about how the Parliament wanted to extend the law with the right of the SBU not to let election candidates and why this has not yet happened.
Newt Gingrich: the Chinese-Russian military Alliance will be unimaginable problem for the United States
Several rockets fall near the american embassy in Baghdad
Espionage of vaccines: China accuses the U.s. of "defame"
Turkey shelled the U.S. military in Syria
Mid-session Paris: Carrefour is coveted!
A triple settling of scores while savagery
a car rushes towards the police vehicle, the driver killed, three injured
Paris opening: doped Carrefour!
Outings – Leisure | Marseille: Raoul Lala, the rat reporter who explored the Mucem
Arnaud Montebourg's Nutella "Made in France" is controversial
© 2021 The Sherbrooke Times.


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Hurricane Florence's state-by-state forecast: See what could happen where you live
The most devastating effects of Hurricane Florence will be in the Carolinas and Virginia, though surrounding states will also see some effects from the powerful storm, which is expected to make landfall late Thursday or early Friday. What's unusual about Florence is that instead of roaring ashore and quickly weakening, a new forecast shows the storm stalling right along the coast and potentially crawling to the south along the Carolina coast.
Here's a state-by-state forecast:
The full fury of Florence should land in North Carolina, where hundreds of thousands of people have been ordered to evacuate.
"Significant impacts are expected from Florence, including storm surge, extreme winds, possible tornadoes and exceptional amounts of rain, which will likely cause flash flooding and eventually serious river flooding," the National Weather Service in Newport, North Carolina, said.
Initially, there will howling winds of up to 120 mph near where the storm comes ashore, and structural damage to homes and buildings is possible.
Rainfall totals of up to 40 inches are possible across eastern North Carolina, which would lead to widespread, "catastrophic flooding." Cities such as Wilmington, Raleigh and Fayetteville are all in the crosshairs for devastating floods.
"This storm looks like it's going to stall over the region and potentially bring tremendous, life-threatening flooding," AccuWeather meteorologist Marshall Moss said.
In addition, destructive, life-threatening ocean waves will roar ashore as the hurricane's eye makes landfall. Up to 12 feet of surge could inundate coastal areas from Cape Fear to Cape Lookout. The worst of this surge will be to the north or northeast of where the center comes ashore, the Weather Channel said.
North Carolina's sister state to the south won't be spared: Coastal areas from Myrtle Beach to Charleston will see a storm surge of up to 6 feet.
Thanks to the storm stalling out, floods from relentless rain will be the primary concern in the Palmetto State. "The main life-threatening risk may be a prolonged heavy rainfall event with associated flooding," the weather service in Columbia, South Carolina, said.
The weather service added that "if the slow southwest drift of Florence pans out, it will bring very dangerous conditions to the northeast South Carolina coast" late Friday into Saturday.
Along the coast of South Carolina, based on the latest track from the National Hurricane Center, strong rip currents, rough surf conditions, coastal flooding and some degree of beach erosion are all also possible, the Charleston weather service office said.
Even if Virginia does not take a direct hit from Florence, heavy rain and flooding remain a real threat. In southeastern Virginia, including the Richmond and Norfolk metro areas, "life-threatening, if not historic rainfall totals" are possible during the Friday-Saturday time frame, the weather service in Wakefield, Virginia, warned.
Maryland, Delaware, Washington, D.C.
Specific repercussions from Florence this far from landfall are still uncertain. Portions of Maryland and Delaware may be on the edge of the excessive rainfall area, especially as the forecast track of the storm has pushed to the south.
"With uncertainty remaining around the exact track of Florence after landfall, it is a bit early to highlight a specific area for heavy rain potential," the weather service in Washington, D.C., said. "However, the threat for significant rainfall and flooding is there for the weekend into early next week."
Although the forecast in the Mountain State is also much less certain this far inland and this far ahead of the storm, "significant rainfall" is possible early next week in West Virginia, the National Weather Service said.
The state's mountainous terrain is always a concern when rain is in the forecast. "There could be devastating floods well in from the coast back in the hills and mountains of West Virginia," AccuWeather's president Joel Myers warned.


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Private life insurers better claim payout ratio to 95% in FY18
BENGALURU: The life insurance industry is honouring more claims, helped by technology and better fraud management. The claims payout ratio has improved significantly, with private industry paying 95.2% of all claims in 2017-18, compared to 93.7% in the previous year, and 88.3% in 2014-15. LIC has long been paying over 98% of its claims. That continues, though it slipped marginally in 2017-18.
In fiscal 2018, 21 of 23 private life insurers paid more than 90% of claims, unlike in 2014-15, when only nine did so and the majority paid out only 50-70% of claims. Claims repudiation (those rejected) by private players is also down to just under 4%, from 4.6%.
Fraud management, tech, regulation help cut rejections
Among the reasons for this improvement, insurers say, is that they have adopted better fraud management techniques at the underwriting stage itself so that they don't have to weed out fakes at the point of claims. "We have robust underwriting practices using data analytics and technology-enabled verification processes. This way, we are able to detect frauds before policy issuance. For the over 10,000 claims we got last year, we paid 98.2%, amounting to Rs 353 crore. We rejected only 178 claims, of which only two were cases of fraud and the remaining were medical non-disclosures, such as terminal ailments," said V Viswanand, deputy MD of Max Life Insurance, which in 2017-18 had a higher claims payout ratio than even LIC — the first time perhaps that a private insurer has beaten the government behemoth.
For years, the life insurance industry has been plagued by fraud syndicates, which operate in places like Vadodara in Gujarat and Bellary in Karnataka. "Such syndicates would mostly operate with the connivance of the police, hospitals and fraudsters. Death claims can be high, ranging from Rs 1 lakh to Rs 1 crore. Frauds were a big bleed for the life insurance industry. But with better technology and stringent fraud management, they have reduced over the years," said an LIC official.
Insurers also say that technology has ensured faster settlement of claims. "Through our insta-claim initiative, our aim is to pay eligible death claims — meeting certain sum assured and policy tenure conditions — within 24 hours. Today, nearly 50% of our death claims are settled in such a manner," said Viswanand.
HDFC Life Insurance has introduced same-day claims processing. "Most fraudulent claims arise within the first year of buying the policy. So, for all customers who've been with us for more than three years, we settle claims within 24 hours. We've honoured 97.8% of individual claims and 99.3% of group claims," said a representative of the insurer.
Personal Finance News-Wealth-Economic Times
Tagged better, claim, FY18, insurers, Life, payout, private, ratio
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This is Olivia. She is from Connecticut, USA but has found herself living in London at 20. She is studying business and is currently an intern with Katie&Jo. She loves that she can wear Katie&Jo pieces either to work, class, or on a night out with friends.


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Lee Speight, Ph.D.
Director, Product Development
Green Biologics, Inc.
Lee attended the University of Pennsylvania for his doctorate in Chemistry (2014) and studied Chemical Biology. He joined Green Biologics immediately after graduate school as a Business Development Analyst. As Green Biologics' interest in adding value to core chemicals grew, his role evolved into product development. Presently, he is the Director, Product Development, for Green Biologics and leads the Product Development and Technical Services team out of the Virginia Biotech Park in Richmond, VA.
Performance Advantages of Bio-n-Butanol
Inclusion of bio-based ingredients into coating formulations has recently been motivated by marketing or corporate sustainability goals. However, innovations into the development and production of bio-n-butanol have revealed an opportunity to improve the performance of formulated products and the production of high-performance derivatives. We demonstrated the comparable performance of bio-n-butanol to petrochemical n-butanol in myriad coatings formulations. These experiments showed that bio-n-butanol is an alternative to petrochemical n-butanol. Examples include epoxy and short-oil alkyds, which highlighted the ability to utilize bio-n-butanol without noticeable changes in the properties or performance of the applied coating. The value of bio-n-butanol as a building block for coatings ingredients showed a dramatic improvement relative to petrochemical n-butanol. We used Fisher esterification and transesterification reactions to demonstrate that bio-n-butanol is capable of improving the crude yield and kinetics of acrylate and acetate ester productions. The butyl acetate produced using bio-n-butanol also demonstrated strong performance as a drop-in when substituted for petrochemical butyl acetate in a PUR coating. In addition to these performance benefits, the use of bio-n-butanol is sustainable and its supply is unrelated to volatile petrochemical commodities. These benefits combined allow formulators and producers to make a sustainable choice that improves their overall value proposition.


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In Sickness and in Wealth
American Hospitals in the Twentieth Century
Rosemary Stevens
American hospitals are unique: a combination of public and private institutions that are at once charities and businesses, social welfare institutions and icons of U.S. science, wealth, and technical achievement. In Sickness and in Wealth helps us understand this huge and often contradictory "industry" and shows that throughout this century the voluntary not-for-profit hospitals have been profit-maximizing enterprises, even though they have viewed themselves as charities serving the community. Although our hospitals have provided the most advanced medical care for acutely sick and curable…
American hospitals are unique: a combination of public and private institutions that are at once charities and businesses, social welfare institutions and icons of U.S. science, wealth, and technical achievement. In Sickness and in Wealth helps us understand this huge and often contradictory "industry" and shows that throughout this century the voluntary not-for-profit hospitals have been profit-maximizing enterprises, even though they have viewed themselves as charities serving the community. Although our hospitals have provided the most advanced medical care for acutely sick and curable patients, they have been much less successful in meeting the needs of the chronically ill and the socially disadvantaged. That, Stevens concludes, is the next urgent task of social policy.
Technology in the Hospital
Joel D. Howell
The Care of Strangers
Charles E. Rosenberg
Allan V. Horwitz
Why Wellness Sells
Colleen Derkatch
Stevens brilliantly views the hospital as a prism of the values and mores of society... She sees the stratification of the hospital population into private, semi-private, and charity patients as a manifestation of the social stratifications of American society.
— Reviews in American History
This book is beautifully written... and is must reading for anyone involved in the current debate on health policy. It will also make delightful reading for those who merely wish to view the shifting social and economic climate in modern America, as seen from the perspective of the hospital.
— New England Journal of Medicine
For me, personally, the book constituted an invitation to rethink the relationship—warts and all—among the benevolent, charitable, and business missions of the hospital, while at the same time disabusing me of my inclination to cite history to support or defend a view I might otherwise have preferred to hold.
— Merlin K. DuVal, M.D., Senior Vice President, Samaritan Health Service, Phoenix, Arizona
Rosemary Stevens, Ph.D.
Rosemary Stevens is professor emeritus of the history and sociology and science at the University of Pennsylvania and the De Witt Wallace Distinguished Scholar in Social Medicine and Public Policy at Weill Cornell Medical College. She is the author of In Sickness and in Wealth: American Hospitals in the Twentieth Century and The Public-Private Health Care State: Essays on the History of American...


Certification company, HPi Verification Services, has expanded into larger office space at Howbery Business Park, Wallingford. The business, which has a 20 year trading history, moved to Howbery in 2010 when its current CEO bought the Certification Services Department of AEA Technology and rebranded it as HPi VS.
The company has a licence from the European Commission to issue CE certificates for recreational boats and yachts, and for different types of pressure equipment, providing its services to clients all over the world. Having a CE Marking on such products is required by law, but is also an essential marketing tool for manufacturers. It enables them to demonstrate that their products conform to EU Product Directives, allowing them access to the entire European market. Clients include Sunseeker Luxury Yachts, General Motors and Oxfordshire boat manufacturer, William Jet Tenders, based in Berinsfield.
Howbery Park's future plans include offering large bespoke design and build office spaces.


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10 symptoms of cancer you could be missing
A lump in the breast, sudden weight loss and blood in the stools. We think we know the signs of cancer. Except we don't – and now experts are encouraging people to be more aware of less-known symptoms that could signal early disease and report them to their GPs.
In the UK, one in two people will be diagnosed with cancer in their lifetime
Research from the London School of Hygiene and Tropical Medicine shows England has some of the poorest survival rates in the Western world for common cancers such as colon, breast, lung, ovarian and stomach. In the UK, one in two people will be diagnosed with cancer in their lifetime and the disease is responsible for a quarter of all deaths. According to the National Institute of Clinical Excellence (Nice), about 5,000 lives a year could be saved by making earlier diagnoses.
But what are we looking for? "A lot of the early symptoms of cancer will be vague and non-specific," says Peter Johnson, professor of medical oncology at Southampton University and lead clinician for Cancer Research UK. "It's these that people need to be aware of and report to their doctors. But we're not good at paying attention to our own bodies, to what's normal for us, so we ignore minor symptoms which occasionally can be caused by early cancer."
Persistent hoarseness can indicate an early, curable head or neck cancer such as one of the vocal cords. ~ Dr David Bloomfield, clinical oncologist at the Sussex Cancer Centre
The good news is that most cancers are curable if caught in the early stages, says Dr David Bloomfield, clinical oncologist at the Sussex Cancer Centre, Royal Sussex County Hospital, and medical director for the Royal College of Radiologists. "Be aware of the red flags [see box below], but if something else is unexplained and unusual for you and doesn't get better in a couple of weeks, get it checked out," he says.
Together we have worked with Cancer Research UK and Britain's leading oncologists to come up with a list of vague symptoms that shouldn't be ignored.
Hoarseness or a croaky voice
Being croaky or hoarse is common with a cold, but if it doesn't get better within two or three weeks, it needs checking out. "Persistent hoarseness can indicate an early, curable head or neck cancer such as one of the vocal cords," says Dr Bloomfield. Today's surgery techniques usually mean minimally invasive removal of the cancer so your voice remains intact – if it's caught early enough.
A stubborn cough should also be checked out with a chest X-ray, especially if it has lasted more than three weeks, as it could also indicate lung cancer, says Prof Johnson.
Heavy night sweats
It's more than likely your duvet or the menopause if you're a woman, but heavy night sweats could also be a sign of lymphoma, a tumour developing in the lymph cells. "People with lymphoma have high metabolisms because lymphoma cells use a lot of energy, so they get severe, drenching night sweats where they need to change their pyjamas and sometimes the bedding," says Dr Shankara Paneesha, consultant haematologist at Spire Parkway Hospital in Birmingham. Other symptoms may include a lump around two centimetres or more in diameter in the armpit, groin or side of the neck.
Persistent heartburn
It's not unusual to feel pain or discomfort after a fatty or spicy meal, but if this has lasted more than two or three weeks and you need to take antacids regularly, it could signal cancer of the stomach or oesophagus, says Prof Johnson. Occasionally, it may also be a sign of pancreatic or ovarian cancer, he says.
Middle back pain
In the UK, about 2.5 million people suffer with back pain. "For around 99 per cent, it's going to be musculoskeletal, but back pain is also one of the more common symptoms of pancreatic cancer," says Prof Pippa Corrie, consultant and associate lecturer in medical oncology at Cambridge University Hospitals NHS Foundation Trust.
"The classic symptom is pain in the upper abdomen that spreads out across the back," she says. The pancreas sits at the back of the abdomen and, as it grows, it starts to invade the nerves that signal pain in the back.
"While most musculoskeletal back pain will occur in the lower back, that associated with pancreatic cancer is about a hand's breadth above that and may also come with other symptoms, such as people being off their food, tiredness and weight loss."
Pink discharge after menopause
Pink discharge from subtle bleeding – or any kind of vaginal bleeding after menopause – should be reported to your doctor as it can be an early sign of endometrial cancer, says Dr Bloomfield. Endometrial cancer is on the rise in the UK because it's associated with being overweight, and as a nation we're getting fatter. The earliest sign is a bit of bleeding and this is a highly treatable cancer if caught early.
Problems urinating
As a man ages, his prostate gland grows, which can cause more frequent urination, especially at night. "If you can't go for a few hours without peeing, or you're having difficulty starting to pass urine, this could indicate an obstruction, such as a prostate cancer," says Prof Johnson. Your doctor can refer you for tests and a biopsy. 'If the test is positive, most men won't need treatment as their cancer may not be harmful, but it needs to be tested to see if it's aggressive,' says Dr Bloomfield.
Strokes, brain injuries and other medical conditions can cause difficulty swallowing but occasionally, it may be a key early symptom of a head and neck cancer such as of the vocal cords, oesophagus, mouth or tongue. 'Caught early, these are often curable,' says Dr Bloomfield. Other symptoms include pain at the back of the mouth. Though more common inn those that drink or smoke heavily, such cancers are on the increase in young people, believed to be caused by transmission of the Human Papilloma Virus (HPV), through unprotected oral sex, explains Prof. Johnson.
Looser stools
You know about blood in your stools but anything significantly different to what's normal for you – colour, texture, frequency or pain – that lasts for two weeks or more should be reported. 'Any sudden changes in your bowel habits including constipation, looser than usual or pain with a strange dragging sensation or dull ache, should be looked into,' says Prof. Johnson. 'It may indicate bowel cancer or in rare cases ovarian or pancreatic cancers.'
A sore that won't heal
Most people know to look for changes to moles such as bleeding, itching or irregularity. 'But other signs of skin cancer can include small lumps on the skin that get bigger, sometimes with an ulcer on top that doesn't heal for 2-4 weeks,' says Prof. Johnson. 'Often they're painless but they may bleed or be itchy.' Good news he explains, is that GPs are good at recognising and referring skin cancers quickly.
Mouth or tongue ulcers
Lots of people get mouth ulcers from viral infections, but these usually clear up within a few days and are quite painful when you have them, says Prof. Johnson. 'But a mouth ulcer that is there 3-4 weeks – with or without pain – needs looking at because it could be a cancer on the tongue or around the mouth,' he says. 'White marks on the tongue as well as thick, white patches on the tongue also need to be checked out because they can indicate changes in the lining of the mouth which can lead onto cancer.'
Source: http://www.telegraph.co.uk
Posted by Above Whispers on February 6, 2016.
Under Health
Tags: Cancer, Ckeck-Up, Diseases, Health, HPV, Symptoms, Women's health


text:
The Flames of Faith
Posted on 1 July, 2017 by yazdi	7 comments
'Lhotse', Air lndia's Boeing 707 began taxiing on the tarmac and as the big aeroplane lost touch with the ground and became airborne, chants of Yatha Ahu Vairyo rent the aircraft. For, this was a very special journey, on a very special mission. Flying on board the chartered plane was a very, very special and important entity – Atash-e-Adaran.
This, then, is the story of a very important and almost miraculous chapter in the history of the Zarathustris. An event which took place in the life time of most of us. Join us as we 'fly' down to the Red Sea port of Aden, situated on the Arabian peninsula. Welcome aboard the 'Lhotse':
Parsees have always been adventurous and enterprising and many have gone to distant shores to seek their fortunes and, wealth and in a number of cases, settled abroad. In a few places they even build Fire Temples to cater to the religious and spiritual needs of the Parsee community settled on these foreign shores. One such Agiary was built at Zanzibar which, unfortunately, had to be closed down when Parsees left that place and the Atash Padsha there just 'died out'. Shanghai in China, too, had a fire temple, which also unfortunately had to be closed down when the communists took over China. Another Agiary in a foreign land was the one at Aden in the country of Yemen.
Aden, in those days, was a thriving trading post, a free port like Singapore. Located at a strategic point on the Arabian peninsula, it was the port ships passed through on their East to West – West to East journeys, via the Suez Canal. Aden had a large number of Parsees – around 1300 – and in the year 1883 they built an aglary there where the consecrated Atash was of Adaren grade. This aglary was built by the Cowasji Dinshaw family who were In the business of shipping. This family also built a mosque for the local Mohamedan population which is known as the Cowasji Masjid and is still in use in Aden. There also used to be a Dokhma in Aden for the use of the Parsees.
In 1967, the British left Yemen and South Yemen turned into a communist country. Aden soon lost its prime position as an important trading post on both sides of the Suez. Business declined and a number of foreigners working there and contributing to its economy started leaving, too. So did the Parsees, many of them who had almost settled there moved back to India or to other places like UK, Canada, etc. Only a few Parsee families were left by the mid-seventies and they, too, were all set to leave.
With the advent of communism, the agiary, dokhma and their funds, etc. all became state property. With all the Parsees set to leave Aden, who would take care of the Atash? That's when Cowasjee Dinshaw, the great grandson of Cowaajee Dinshaw who had built the aglary and dokhma in Aden In the last century, decided that he would not let the Holy Atash, which had sustained and nurtured the community in this land away from home, just die away as the one at Zanzibar had. Most of the Parsees in Aden had prospered and done very well for themselves, and they strongly believed it was due to the blessings of the Atash Padsha. The Atash had provided them with spiritual sustenance and was an important focal point of keeping the community united, alive and energetic.
Cowasjee Dinshaw firmly believed that this Atash had miraculous powers. During the fight for ousting the British from Yemen, inspite of all the bombings and destruction all around, the Agiary was never touched even by a splinter, leave alone the various bombs that were exploding all around it. Ultimately, in 1967, the British left Yemen and the communists came to power. Soon, changes began even in the business community and one by one the foreigners started moving out of Aden. Now with the impending withdrawal of the Parsees from this ancient Islamic and new communist state, wnat was to happen to our Holy Fire?
The first decision was that the Atash had to be moved out of Aden. Alternate places where it could be enthroned were considered. The first was in a Daremeher in Iran. When Cowasjee Dinshaw approached the head of tne Zarthusti Anjumans in Iran, they expressed their willingness to receive the Atash. But they had two conditions. One, they would follow the Fasli calendar for all religious ceremonies and, secondly, they would not be able to keep the Varsiaji in the Daremeher. Both these conditions were unacceptable to Mr. Dinshaw. So the next alternative was explored. This was a House of Worship in London. But the London-based Parsees were concerned that since some smoke would emanate from the Fire, it would be difficult for them to enthrone the Holy Fire in London!
That's when Cowasjee felt that the best place for the Holy Fire to be would be in India where it would be safe, glowing and 'alive'. The next step was to obtain permission from the government of South Yemen to move the Atash out of that country. Being a newly formed communist regime, they were not exactly very understanding of religious sentiments. Cowasjee Dinshaw appealed to the government for permission to move the Holy Atash to India. This was refused. He then appealed to Queen Elizabeth as the head of the Commonwealth, the World Bank as well as the Government of India.
There were no encouraging or helpful responses from Elizabeth or the World Bank. It was the Indian government that really worked hard in this matter. India, in those days was ruled by the late Prime Minister, Mrs. Indira Gandhi and the foreign Minister was Mr. Y.B. Chavan, the strongman from Maharashtra. A petition was sent to the Prime Minister and not surprisingly was favourably received by her. The Prime Minister asked Y. B. Chavan to take all measures possible to persuade the South Yemeni government to release the 'Holy Atash'. This was not as easy as it sounded. The South Yemeni government was not very keen to let the Atash be moved out of Aden, being communists and thus having little sympathy towards religious spiritual sentiments.
It took a lot of persuasion from the Indian Foreign Ministry, Y.B. Chavan and even Mrs. Gandhi personally, to make the South Yemeni government finally agree to let the Parsees move the Holy Atash to India, In a meeting of the Non Aligned Nations held in Colombo, Y.B. Chavan personally met the Head of the South Yemeni government who was also present there and once again pressed the case for the release of the Holy Atash to India. At last, the South Yemeni Government agreed and, indeed, it was a moment of joy and relief for the Parsees of Aden, The condition was that it would have to be moved out at midnight. This was agreed to by Mr. Dinshaw. But much more of trials and tribulations had to be passed through almost like a test through fire itself. Further permission had to be taken that the Holy Atash would not be viewed by any non-Zarthustis which, too, was granted very reluctantly by the then South Yemeni government, after a lot of persuasion on the part of our Foreign Ministry.
No sooner was this news known, then a fresh controversy broke out in the community, back home in India. There was a lot of debate on how the Holy Atash could be transported. Cowasjee Dinshaw approached Field Marshall Sam Manecksha to chalk out the best land route to transport the Holy Fire. Manecksha drew up a route, but that meant passing through Mecca and Medina, holiest cities of Islam. Now, this would not have been possible since no non-Muslims are allowed to even enter these two cities.
Also, from the Zarthusti theological and religious point of view, transport through land routes was ruled out as there is an injunction in the Denkard on carrying the Holy Fire over wide expanse of waters, and since one would have to cross a number of rivers, this would create a major difficulty. Also, from the practical point of view, even on a different route drawn up by Manecksha, this was not a very good idea. One, it would have involved taking permission from a number of different countries (all Islamic states) to move the Atash through their land. Even the best route would have taken at least two thousand kilometers be covered. How was the Atash to be tended to five imes a day, every day on a journey that would have taken months to complete by road? Also, how safe would our Holy Atash be from the prying eyes of curious, suspicious and even hostile locals? Plus, the logistics of the whole exercise would have been too cumbersome to carry out. One would need a set of very hardy Parsi-Zarthusti drivers and mechanics to drive and maintain the vehicle. Again, the route would be over very rough and dry terrain, most of it desert. All this seemed like a very improbable venture to carry out. Thus, moving over a land route had to be ruled out.
For the same reason (injunction in the Denkard), the sea route was discounted. Moving by sea would have involved carrying the Holy Fire on a ship and travelling from Aden to Bombay. But on this point the eiders, scholars and those learned in our scriptural matters expressed their strong disapproval. From the Zarathusti point of view, according to them the Holy Fire is not to be carried over the waters. This is because the sea unfortunately contains within its waters a lot of pollutants, like discharge from the ships and freighters. Transporting the Holy Fire over such impurities would be nothing short of sacrilege, amounting to defiling the Atash Padsha.
So, what other avenue was left but to fly the Holy Fire over to India. Have you heard Of carrying fire in an aircraft? From the point of security that was a highly dangerous thing to do. It could result in the loss of not only the aircraft but also the people escorting the fire. Yet as the concerned people thought about and debated on these issues, the more it became clear that this was the only way to transport the Atash. Thus the decision was taken to fly it to Bombay.
Thus Air India was contacted. Air India agreed to provide an aircraft on a charter basis. This was a Boeing 707. Air India by then had begun inducting 747s, the giant Jumbos into its fleet.
Now even an airline started by a Parsee does not routinely fly Fire – that, too, consecrated and of the Adaran grade. To transport this very special 'passenger' it was essential that purity and some religious injunctions be observed. One of the first one amongst these was that only Parsee Zarthustis be on board the aircraft. Thus Air India began the exercise of identifying only Parsi crew who would escort the Holy Fire. Capt. Sam Pedder was contacted and nominated for this religious adventure. For this, he was required to fly a few 707s of Indian Airlines to clock-in some more hours for flying a Boeing 707 as he had by now graduated onto the 747 Jumbo Jets, giants of the skies.
The Engineering department of Air India, under the supervision of their then Deputy Director of Engineering, Mr. N.S. Mistry, prepared a special urn to carry the Holy Fire in. They also made a big box which would hold the urn. These were made of aluminium and other metals.
The configuration of the First Class section in the special Aircraft – Lhotse – had to be changed to accommodate the box containing the urn which would be carrying the fire.
Soon it was time for the Holy Fire to leave the shores of Aden where it had provided its light and protection, its blessings and goodwill to the faithful.
Just on the eve of the departure an unexpected problem arose. The police commissioner of Aden, who was a Muslim-turned communist, informed the remaining few Parsees who were looking after the Fire that he would be coming over the next day to personally inspect the Fire and the urn and the box that would be carrying it. No amount of entreaties that the Holy Fire could not be subjected to the gaze of a non-Zarthusti seemed to have any effect on him. The fact that permission was obtained that the Fire would not be viewed by any non-Zarthusti did not cut much ice with this person, who insisted on his demand on the grounds that the big box could be used for purposes of smuggling!
He announced that he would be there when the Fire was being moved out and the Fire be kept ready for his inspection or else he would not give any permission to move it out of the agiary premises. Imagine the state of mind of the four-five Parsees left behind. Here they were trying their best to protect the Fire to ensure its survival and journey to India and here was a thunderbolt from a man who seemed unsympathetic and stubborn. Would the sanctity of the Atash be preserved after it was 'inspected' by a non-Zarthusti? After all, there are esoteric reasons why this is forbidden.
The Parsees prayed to Ahura Mazda, to the Prophet Zarathustra. They prayed to the Holy Fire itself and asked to be delivered from this impending catastrophe. At midnight there was a knock on the door of the agiary. The Parsees looked at each other with dismay and anguish. So the commissioner had come to defile our cherished Atash Padsha, they cried.
The door was opened with a heavy heart. Out on the steps stood a person and he had brought some news. The commissioner had just died, most unexpectedly! The Holy Atash was now safe from the eyes of those who need not gaze at it.
Soon afterwards, in a convoy the Atash was taken to the airport. The aircraft had just arrived from Bombay and the engines were not even switched off. No non-Zarthusti touched the aircraft. The aircraft had been sanctified with well-water and taro. Cowasjee Dinshaw was aboard the same with the Head Priest of Udwada, Dastoorjee Kekobad Phirozjee, who had provided a lot of religious advice on the whole exercise and, of course, his moral support. There were five other priests on board, too. As soon as 'Lhotse' landed, two mobeds holding British citizenship rushed to the Agiary. By then Dasturjee Minocher Manecksha who had tended the Fire for many years at the Aden Agiary had offered Boi to the Fire in the Ushahin Geh, for the last time in Aden. From there the Atash was brought in its new container in a convoy to the airport. A pavi was built to ensure the sanctity of the Atash Padsha. The Yemeni government had provided motorcycle escort to the entourage. The Holy Fire was carried onto the aircraft. In a few minutes the aircraft, the engines of which were never switched off even after its long journey from Bombay, was taxiing and was soon airborne. History was made as live fire was carried in an aircraft which otherwise was a very dangerous thing to do. As the aircraft took off, the Yemeni officials gave it a 21-gun salute, the sounds of which were heard all over Aden. This truly signified an end of an era for Aden, The all-Parsee crew as well as the other Parsee escorts kept on chanting our prayers.
The mobeds who were accompanying the Holy Fire did the Padyab Kushti, Atash Niyaesh and other prayers. They often opened the box to offer sandalwood to ensure that the fire was still glowing and had not died out. They did this with regard to all due ceremonies and by reciting the necessary prayers. Opening the container and feeding sandalwood to the fire at the height of 30,000 feet was, indeed, a very dangerous thing to do, as any flames escaping out could lead to a major explosion in mid-air due to the highly pressurized cabin conditions. Yet, every time, they opened the box to look at the Fire, they found it resting quietly, just glowing softly and serenely, the flames dancing gently, almost as if enjoying the unique journey.
After flying for almost four hours, the aircraft landed at the Santa Cruz airport, Bombay, at around 7.00 a.m. The airport was chock-a block with Parsees who had come to receive their Holy Atash from across the seas. With due respects, the box was slowly taken down the steps. A pavi was built around the container and Yatha Ahu Vairyo was chanted, ceremoniously. Dasturjee touched the ground of Mother Earth in thanksgiving for a safe journey and with a prayer on his lips opened the box. Lo and behold, the Fire that was resting silently by just glowing softly while in midair, now leaped a few feet, as if in sheer ecstasy. The Flames of Faith danced and swirled as they came in touch with the atmosphere of Mother India – the land that has been home to its devotees (the Zarathustris and the Hindus) since centuries. Here, in the land that has been home to the largest number of the world's great religions, the Holy Atash Padsha from Aden at last felt at home – secure and safe.
The Atash Padsha was now taken to the Soonawalla Agiary at Mahim in a special luxury bus for being 'rested' for the new hours. This was taken under police escort. The Atash was offered Machi and Boi for the Havan Geh, and later in the Rapithwan geh, too. The Mahim agiary was packed with hundreds of ordinary Parsee-Zarthustis who had come to pay their respects to the Atash Padsha. Around 01.30 at noon, once again the Holy Fire was taken on board the special bus and this time the second Phase of this historical Journey commenced… to the Adenwala Aglary at Lonavala in the hills of the Western ghats. This is where the Atash would be enthroned.
A pavi had been created around the bus and a chain attached to it to maintain contact always with the earth. In an absolutely unprecedented move, the Bombay to Pune highway, one of the busiest land routes in the country on which Lonavala is situated, was closed to all traffic upto Lonavala from Bombay. A motorcycle escort was once again provided by the government of Maharashtra to the convoy. A number of Parsees followed the same in eight buses plus many went along in their own cars and vehicles (around 60-70 automobiles) and the route was lined with cheering Parsees, praying and expressing their gratitude to the Lord for the safe passage of the Holy Fire.
On 14th November, 1976, Roj Behram, Mah Khordad, YZ 1346, the Atash Padsha which was first consecrated in Aden in the year 1883 in the Adenwalla Agiary at Aden in Yemen, arrived at its new home, the Adenwalla Agiary at Lonawala, India.
With due ceremonies and prayers (Machi and Boi ceremonies in the Ujiren Geh) the Atash Padsha was installed in the specially created sanctum sanctorum next to that of the original Atash Padsha of the Lonavala agiary (which is of the Dadgah grade). A jashan for thanksgiving was later conducted in the evening. Once again, the agiary was full Of devotees and the atmosphere was one of great joy and devotion.
The costs and expenses which ran into lakhs of rupees for the complete operation were borne by Mr. Cowasjee Dinshaw and his wife, personally. When this writer enquired with him what was the sum spent he very modestly declined to mention the figure. Such humility and modesty is so rare and thus praiseworthy especially in the times we live in today.
Today, both the Atash Padshas blaze forth in joyous glory. The Atash from Aden stands testimony to those brave souls who consecrated the Fire in a foreign land and had the foresight and courage to bring it to safety when times became difficult. The radiant flames of this Atash bear testimony to the miracles that the Lord keeps creating, strengthening the faith of the faithful and reinforcing the message of hope, courage, devotion, faith and perseverance.
There are some more messages in this story and one of these is that after the flight of the Zarthustis from Iran to India, India has been the only place where we, the Parsi-Zarathustis have been able to build and sustain our holy Fire Temples without any fear of these being destroyed, desecrated or defiled. Even in the much touted democracies of the West, we may not be able to build fire temples where only zarathustis are permitted entry. No matter whatever disadvantages and inconveniences one may face here in terms of systems, infrastructure, etc. (and these are felt by people of all races and religions here) we have lived here freely and prospered, too. Our places of worship are not in danger of being destroyed or closed down. Indeed, we need to think as to why our ancestors were guided (divine guidance, I firmly believe) to come to India when they were seeking refuge and not go elsewhere.
Indeed, if there is talk of closing agiaries today, it is unfortunately within the community itself and stems from tragic issues like not having sufficient number of priests to tend to the holy fires in remote places like small villages and towns. But hold it just a moment here. The Adenwalla Agiary at Lonavala where the Atash of this story resides today is tended by just one priest, day in and day out. Dasturjee Marzban Gonda has to be heard reciting our prayers at this Fire temple to understand the devotion and love that Atash can inspire.
Also, it we use our minds and resources, the Lord will provide support and guidance. If a few determined individuals could fly down the Holy Atash under very trying circumstances, facing various odds, surely we, too, can look at the possibility of keeping the fires glowing in all our aglaries and daremehers.
The story of bringing over the Holy Atash from Aden to Lonavala is a true story, little known and heard but it has many lessons for us all. It all happened just twenty-two years ago! It is part of our history. The Iranians of old were not known for recording their history. This is, therefore, just a small and humble attempt to do so, so that this story of devotion and courage is not forgotten and also so that we keep learning from history and not become victims of being ignorant of our past.
May the various Atash Padshas in various Fire temples continue to blaze and glow with love and joy, power and radiance, showering their blessings not only on our numerically tiny community, but also on this land of Bharat which has protected and sustained us, socially, materially and spiritually.
Sauche buye ahmi nmane… dareghemchit aipi zravanem
(May Thou (Holy Fire) blaze till eternity).
by Pervez Daruwala
Courtesy : Cowasji Dinshaw Trust
Agiaries and Atash Behrams
Agreras K. Dastur
1 July, 2017	10:27 pm
It was indeed painful to know and understand the difficulties of bringing
ATASH PADSHA all from Aden to India
(Mumbai)
May PAK DADAR AHURAMAZDA Bless the persons who has taken pains to bring ATASH
PADSHAH.
Manijeh Mistry
Little known and not recorded is another fact. My next door neighbour, Mr Rusi Mori from elava building, contractor baug, mahim (who was not a priest) also travelled to Aden on this flight. After a lot of controversy he was taken along. Reason being that he had lived for many years in Aden, spoke the language and had contacts with locals and govt officials and knew the layout of the land in case any last minute route changes were needed.
Another fact was that his old mother who had also lived in aden was keen to pay her respects to this holy fire. She was housebound due to health reasons, so the bus made a special stop in front of our building where she paid respects from the balcony as did we all from our respective balconies. Nobody was allowed near the bus. This was en route to the Mahim agiary.
One more fact. Many young men from our colony had the opportunity to go and wash and clean the airplane before its special journey.
I always believe in miracles and indeed this was one we were fortunate enough to witness.
Manijeh
Noshir L Hansotia
2 July, 2017	9:57 pm
Our Community maybe shrinking but the POWER of our HERITAGE & Parsi CULTURE thrive. We continue to be the tallest tree in every forest we share!!! Good Thoughts, Good Words & Good Deeds lives on as our 'calling card'!!! God has Blessed us to be part of a terrific Community & I thank Him everyday.
Noshir Hansotia
14 September, 2017	1:31 am
SOOOOO Very PROUD to be a Zoroastrian & a Parsi. Love this community.
CYRUS MODY
29 June, 2018	9:31 pm
We are the greatest community on earth… Every Parsee is very proud to be one… We are proud of our tradition, our culture, our FOOD, but are very saddened that we are a dying community & very soon will be reduced to a tribe.
We must decide now, do we officially accept the children of the Parsee boy can become Paree's or we will be short lived.
CA RUMY PARVEZ NAGWASWALA
Makes me feel proud and honoured to be a Parsi.
May the Atashbajiwala padshah continue to show us way to prosper and thrive as a larger responsible community having regards to the country which has always stood by us ever since we came here
Zarine limki
Thanx a million to be previleged to.get true knowledge of transfer of our pious atash from a Aden in spite of numerous hardships. God bless our community n let it prosper till eternity.


text:
How Trump's Tariffs Are Creating Jobs — for Canadians
A tariff loophole lets companies ship small boxes across the border duty free. So the huge shipments are now heading to warehouses in Canadian and Mexican border towns, instead of the U.S.
by Lydia DePillis
A UPS worker sorts packages in the back of his truck. UPS, DHL and FedEx lobbied Congress to raise the "de minimis" — the dollar value below which imports wouldn't be subject to duties or the paperwork required of larger shipments. (Paul J. Richards/AFP/Getty Images)
A few months ago, Elliot Markillie started getting calls about small boxes.
He works for a logistics company near Vancouver, British Columbia, called a52 that handles distribution for big apparel and footwear brands. The brands source their goods from China and had just been hit with steep tariffs, on top of the duties already applied to clothes and shoes.
But, the brands had learned, there might be an out: According to U.S. customs rules, packages worth less than $800 — known as the de minimis threshold — don't have to pay duties at all. They just have to ship items directly to consumers one at a time, rather than in bulk to stores or U.S.-based warehouses.
The result: Companies now have an incentive to use fulfillment centers in Canada and Mexico rather than the United States.
Here's how it works. Instead of coming into the Port of Seattle, say, a shipping container or cargo plane full of Chinese goods comes into Vancouver, and pallets full of goods are transferred to a52's warehouse. As goods are ordered from a52's clients' websites, they are individually packaged with a mailing label and sent via a courier service like UPS or FedEx across the border to their destination. There is no tariff code, because there is no tariff, and precious little other information about the contents of each package.
About 10 of Markillie's clients have switched to this kind of shipping, he says, or are in the process of doing so.
"It's a huge advantage," Markillie said. "We already had clients that were doing this ahead of the tariffs. But that's definitely surged the interest that we're getting."
As a result, warehousing jobs are now being created in border towns in Canada and Mexico that otherwise would be located in the U.S. The impact thus far is likely small, but it is poised to accelerate as companies adopt the workaround.
Experts and retail industry players also warn there's an increased risk of counterfeits and illicit goods slipping through in a firehose of small shipments that customs officials can't keep up with.
Take the toy business, which doesn't even have tariffs, but does face a number of consumer safety regulations that are often enforced through the customs inspection process when retailers bring in whole pallets of Barbies or Legos. Items shipped one at a time in containers or air cargo holds filled with thousands of other individual boxes are much harder to police.
Rebecca Mond, who represents the Toy Association, says that gives an edge to manufacturers of toys that might be unsafe or fake. "If you were to throw a ball, you could pretty easily catch it," Mond said. "But if I were to open up a jar and throw all the marbles, you'd have a hard time catching them all."
Another side effect is more subtle: What happens to the United States' leverage in trade negotiations when tariffs are so easy to avoid? Although the Trump administration's steep duties have caused real pain for many industries, in general tariffs as a tool are supposed to give other countries an incentive to grant more access to their own markets.
That's what worries Elizabeth Baltzan, a former trade policy counsel to House Democrats on the Ways and Means Committee who is now a consultant and senior fellow at the Open Markets Institute, an anti-monopoly think tank.
"De minimis loopholes are basically just another way of unilaterally disarming," Baltzan said. "Other countries don't do this to themselves."
As the Trade War Drags on, Shipments Too Small to Be Tariffed Are on the Rise
Estimated annual value of de minimis imports from China.
Note: Figures are estimated by the U.S. Census Bureau. Source: U.S. Census Bureau (Vignesh Ramachandran and Sisi Wei/ProPublica)
The Census Bureau, which tracks the approximate dollar value of packages too small to record precisely, shows a 12% increase in shipments from China for 2019 through July over the same period last year. The number of small packages coming into the U.S. jumped 46% in fiscal year 2018 after a steadier rise over the past decade, according to Customs and Border Protection. The agency is now processing 1.8 million such items per day.
President Donald Trump's tariffs on Chinese imports, which hit a huge swath of consumer goods, are making those shipments a much more valuable channel than they used to be. It's still less than 1% of total imports from the U.S., but it is growing quickly as companies configure their supply chains to take advantage of it.
"We're talking about businesses and companies that are restructuring their business behaviors to take advantage of this loophole," said Amy Magnus, director of compliance for customs broker Deringer. "This is an explosion of business. Everybody would like to be able to be a part of this."
The "de minimis" threshold, as the $800 limit is known, is a longstanding part of the international trading system. Countries decide that they don't want to bother their customs officials with trivially small imports or travelers bringing in gifts, so they wave through low-value items. The exemption's use had already started to grow, as cross-border e-commerce gained steam — and as a result of a little-noticed change in the law.
In 2015, an omnibus customs bill skated through Congress. But it included a large shift in how small shipments are handled: The de minimis threshold quadrupled from $200 to $800, vastly expanding the number of items that could come into the country duty-free and with little paperwork.
Industries that have long battled counterfeit goods noticed a competitive uptick from imported knockoffs. According to CBP, 90% of the intellectual property-based seizures it made in 2018 came through international mail or express shipments, the majority of which fell under the de minimis threshold. International mail has also been the main conduit for illicit pharmaceuticals and dangerous drugs like fentanyl.
The exemption is also probably larger than it looks, because it's difficult to tell whether a shipment is actually worth less than $800 or not.
"There's a lot of fudging of invoices now, just to get under that $800 number," said Dave Bryant, a Vancouver-based importer who also trains people to set up e-commerce businesses. "International sellers more or less have impunity. You get caught, and how are you going to go after someone in China vs. someone in Buffalo?"
Customs officials are aware of that problem, and they have announced a pilot program to see what information they could reasonably ask shippers and online marketplaces to provide about small packages that would help inspectors track down infringing content. But it's voluntary, and the Express Association of America — which represents UPS, FedEx and DHL — said its members haven't decided whether to participate. Amazon and eBay declined to comment.
And then, starting in early 2018, Trump's new tariffs on Chinese imports tilted the scale even further.
Some companies have already set up foreign trade zones to manage tariff payments, but imported goods sold in the U.S. still have to pay them. Columbia Sportswear has foreign trade zones in Oregon and Kentucky, and it is considering what to do if tariffs of up to 52% on goods like waterproof footwear aren't removed soon.
"Moving these things is not something we want to do," said Peter Bragdon, the company's chief administrative officer. "But once more parties have invested outside the U.S., there are going to be people invested in keeping things the way they are. Fast forward five years, you could just say, let's have the e-commerce done elsewhere.'"
Columbia Sportswear is part of a coalition that's lobbying to allow goods routed through foreign trade zones to also benefit from de minimis treatment, arguing that they're better able to monitor for any counterfeit goods or illicit drugs. That would at least weaken the incentive to move distribution across the border and help protect warehouse employment — like the 6,700 jobs in Columbus, Ohio's foreign trade zone, which is occupied mostly by consumer goods companies like Burton and the Gap.
"In my estimation, this flat out encourages offshoring," said the zone's manager, Angie Atwood. "You can serve from just a few hours north the same customers in the same amount of time."
But allowing foreign trade zones to fulfill e-commerce orders duty-free would expand the exemption, not narrow it, which doesn't help domestic companies that benefit from tariffs because they produce goods in the U.S. instead of importing them.
The bigger problem for those being affected by the offshoring of fulfillment: Powerful industry associations remain in favor of it, from the National Retail Federation to the National Association of Manufacturers.
Companies Are Using a Depression-Era Law to Escape Trump's Tariffs — and It's Costing Them
Tariffs are hurting U.S. companies' bottom lines. Free Trade Zones, a 1930s rule which they can use to shield themselves from those costs, require expensive legal help. One Michigan manufacturer called it "a no-win situation."
U.S. brands and retailers are now in a situation where direct-to-consumer imports can avoid extra inspections and paperwork as well as the cost of astronomically high tariffs. In order to capitalize, larger companies are setting up e-commerce operations in Canada and Mexico with the help of specialized logistics providers.
"ELIMINATE DUTIES?" one brochure from San Diego-based XB Fulfillment reads. "A guide for e-commerce companies to use new customs regulation 321 to do just that!" The brochure then names 29 companies that it says are now delivering orders to the U.S. from a Mexican fulfillment operation, including Dell, Crocs, Sony and Honeywell. All of those either did not respond or declined to comment to ProPublica.
E-commerce platforms also love the de minimis exemption, but not for the obvious reasons.
Amazon, for example, prioritizes delivery speeds too much to easily take advantage of cross-border de minimis shipments. The surest way to get something to a Prime member fast is to stock the item at a distribution center nearby, and a warehouse in Canada or Mexico might be too far away to fulfill the promise of one-day shipping.
For that reason, Amazon says it's not changing its vast delivery network in order to import goods duty-free itself. However, a small-scale seller might source inventory from abroad — say, coffee cups from Mexico — in shipments worth less than $800 each, and then send them into Amazon's fulfillment system, so the tariffs are avoided anyway. "That seller is 100% benefiting from de minimis," said Amazon spokeswoman Jill Kerr.
EBay doesn't have any distribution operations of its own, but its members almost exclusively use de minimis shipments both for deliveries and returns; it's encouraging its sellers to write their members of Congress asking them to support keeping the threshold where it is.
And they're having to play defense these days, because the White House may want to change it.
In congressional hearings, U.S. Trade Representative Robert Lighthizer has sympathized with the critics of the de minimis exemption and voiced concern about potential abuse. And in the updated North American Free Trade Agreement, the chapter on trade facilitation includes a footnote that says parties could lower their de minimis thresholds to match those of other parties. Despite concerned letters from representatives, Lighthizer has not said he wouldn't seek the authority to do so in the bill Congress will have to pass to implement the agreement.
In that way, Lighthizer seems to agree more with the Canadians, who have fought hard to keep their de minimis threshold low — just 20 Canadian dollars, and $150 in the new NAFTA.
Since Canada also imposes a national sales tax at the border, allowing de minimis goods to come in tax-free under a higher threshold would mean losing government revenue. Domestic retailers have also been slower to adopt e-commerce than their American counterparts, and so most of their goods would be at a huge price disadvantage to anything arriving under a raised de minimis threshold.
According to Karl Littler, senior vice president for public affairs at the Retail Council of Canada, a pair of shoes that cost $50 when imported under de minimis would have to retail for $68 if sold in a store.
"From a domestic merchant perspective, we have to bear the cost of duties on imports, and we have to collect and remit sales taxes, and we're the ones who invest and hire here," Littler said. "So why the hell are you letting a warehouse in Schenectady get an $18 advantage on a $50 pair of shoes?"
Everything You Need to Play Baseball Is Made in China — and Getting Hit by Trump's Tariffs
Baseball is America's pastime, but prices on its China-made gear are about to rise as the trade war escalates. Golf, lacrosse, basketball and other sports will feel the pinch, too.


The new Cisco CCNA Voice certification can help you verify that you have the specialized voice- over-IP (VoIP) skills that are in high demand among employers. Not sure if the Cisco CCNA Voice certification is the right path for your career? Read on for information and resource links that will help in your decision making.
1. What are the industry trends that motivated Cisco to create the CCNA Voice concentration?
Today, organizations of all types are moving toward a single, IP-based network that carries data, voice, and video traffic. But VoIP and related applications have characteristics and issues that are distinctly different from those of data traffic. Understanding voice networking requires specialized knowledge and skills, a fact that many employers now recognize.
Another important consideration is to meet the transition needs of organizations that currently operate traditional telecom environments. The move from analog TDM to digital VoIP technology systems continues to drive infrastructure improvements for organizations of all sizes and industries. Up to 80 percent of global companies are evaluating IP telephony solutions. These companies are seeking the productivity, cost, and end-user feature benefits that come with using the network as the platform for VoIP.
2. What do employers say about their needs for people with this type of knowledge and skill?
According to a Forrester Consulting Research: Closing the IT Skills Networking Gap on behalf of Cisco, 69 percent of approximately 1500 companies surveyed expect to employ a dedicated voice specialist by 2012. Only 40 percent of respondents have voice specialists today, which translates to a nearly 75 percent growth rate for these jobs.
3. Where will the CCNA Voice concentration be the most relevant?
With the Cisco CCNA Voice certification, you'll be ready for specialized job roles such as voice administrator, voice engineer, and voice manager. The CCNA Voice training and certification are for people early in their VoIP careers, as well as for career IT professionals who wish to gain VoIP expertise and skills.
The CCNA Voice certification will give you an overview of Cisco Unified Communications applications (presence, mobility, video, TelePresence, and so on). You'll learn the skills to handle voice infrastructure (IP telephony hardware, handsets, call manager software, voicemail, and so on). In contrast to vendor-neutral certifications, passing the CCNA Voice exam confirms that you can perform baseline installation, operation, and maintenance tasks on Cisco VoIP solutions, particularly for the Smart Business Communications System telephony system for 8 to 250 phone lines.
4. Is the CCNA Voice path right for you?
The choice to pursue a networking specialist or generalist path is an important career decision. Your interests, the jobs available in your area, and other factors will likely influence your choice.
Your potential salary is another important factor, and industry surveys show that IT specialists receive higher compensation. Certification Magazine's 2007 annual salary survey found a worldwide average salary of US$74,810 for people with a CCNA certification. In comparison, attaining the professional-level Cisco CCVP certification beyond the CCNA resulted in a 23 percent higher salary, at an average of US$92,350.
All of the CCNA concentrations help you to distinguish yourself in the highly competitive world of IT networking. CCNA Voice takes full advantage of your current CCNA certification as a foundation, while specifically preparing you for new career opportunities in voice networking.
CCNA remains the certification of choice for individuals who want to demonstrate a solid foundation in core routing and switching skills, and then later advance as network generalists.
5. Will the CCNA Voice concentration lead to higher-level certifications?
The CCNA Voice certification is the prerequisite for the CCVP professional-level certification.
6. If I already have a CCNA certification, what's my best path to becoming a Voice Specialist?
With the introduction of the CCNAs, Cisco has changed the prerequisites and paths to higher-level certifications. To become a voice specialist, one possible path to pursue is shown below. Please note, there are no pre-requisites to become a CCIE.
7. Are there any prerequisites for the CCNA Voice certification?
Passing the original CCNA certification is required before you can receive any of the CCNA concentrations. You may take one or more CCNA certification exams without retaking the original CCNA exam. In addition, through June 23, 2009, CCNA will be accepted as a pre-requisite for CCVP instead of CCNA Voice to accomodate those in process or starting their CCVP.
8. How do you get training for the CCNA Voice certification?
As of mid-2008, instructor-led training courses are only available through Cisco Learning Partners. For CCNA Voice, the recommended training is Implementing Cisco IOS Unified Communications (IIUC), a five-day, instructor-led course.
9. What are the details about the CCNA Voice course and exam?
Only one exam is required for the CCNA Voice certification: Cisco 640-460. The suggested IIUC training course covers the components of the Cisco Unified Communications Architecture, public switched telephone network (PSTN) technologies, interconnecting VoIP with service provider networks, Cisco Unified Communications Manager Express, Cisco Unity Express, Cisco Smart Business Communications System Unified Communications 500 Series solution, and basic maintenance and operations tasks for Cisco Unified Communications Manager Express deployments. In-classroom labs enhance the learning experience.
10. Where can I get more information about the CCNA Voice concentration?
Visit our CCNA Voice page here on the Cisco Learning Network.


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NASA Posters | Apollo 8 - S-IVB Rocket Stage
"It ain't just rocket science."
The S-IVB ROCKET stage played several important roles in NASA's 1960s and 1970s manned space programs. The 58.4-foot-long, 21.7-foot-wide stage, which comprised a single restartable J-2 rocket engine, a forward liquid hydrogen tank, and an aft liquid oxygen tank, served as the second stage of the two-stage Apollo Saturn IB rocket and the third stage of the three-stage Apollo Saturn V.


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Кристиан Зигфрид фон Плессен (;  — , ) — датский государственный, политический и дипломатический деятель.

Биография
Представитель старинного дворянского рода фон Плессен из Мекленбурга, известного с 1097 года. Сын гофмейстера герцога Кристиана Людвига II Мекленбургского. Отец политиков Кристиана и Карла фон Плессенов.

Образование получил в Рыцарской академии в Люнебурге (1663—1666). С 1670 года служил в органах управления Шверина.

В 1678 году поступил на службу к королю Дании. С февраля 1680 года фон Плессен был губернатором округа Вордингборг.

До 1700 года занимал важные государственный должности. Служил камергером, был тайным советником и гофмейстером принца Георга Датского, которого в 1683 году сопровождал в Лондон для бракосочетания с Анной Стюарт, позже королевой Великобритании. Был воспитателей принца Карла Датского (1680—1729).

Прекрасный экономист, в 1692 г. был назначен Фредериком IV министром финансов и президентом Торговой палаты Датского королевства, сумел навести порядок в крайне стеснённых финансах государства.

Дипломат. С 1696 по 1698 год находился в Лондоне, участвовал в заключении Рейсвейкского мирного договора (1697).

В 1700 году из-за действий конкурентов он был уволен со своих постов. В 1702—1703 годах — датский посланник в Лондоне. Пользовался доверием английской королевы Анны.

До 1714 года состоял на службе у принца Георга Датского.

Награды
 Орден Данеброг (1684)
 Орден Слона (1695)

Примечания

Ссылки
 Christian Siegfried von Plessen (1646—1723)
 Slægten von Plessens besiddelser i Danmark

Политики Дании
Дипломаты Дании
Послы Дании в Великобритании
Министры финансов Дании

redpajama_set_name: RedPajamaWikipedia


Unfortunately, most insurance companies do not cover congenital conditions and most of our patients are self-paying. If your insurance company covers the cost of treatment or diagnostic tests, then we would be glad to assist you with the refund claim or claim directly from your insurance company on your behalf.
Surgical treatment costs will depend on the type of operation, the medical material used and the specific circumstances of each patient. Following your consultation and if you are a candidate for a surgical treatment, an all inclusive cost will be quoted (covering medical material, hospital fees, anaesthetist fees and surgeon's fee and any follow up consultations).
As an indication, for self-paying patients, the all inclusive cost for congenital curvature correction surgery starts at £5500.


Have you heard of Apartment Guide's Your Picks. Your Place. Sweepstakes?
If not, do I have a treat for you!
From now until August 10 you can visit YourPicksYourPlace.com to vote for your favorite room featuring furniture picks by featured bloggers. Right now, Your Picks. Your Place. is featuring home office designs by bloggers including How Does She, The Inspired Room, Hoosier Homemade and Shabby Creek Cottage.
You can vote once a day, and voting makes you eligible for the $10,000 grand prize or one of 8 $250 weekly prizes that you can put toward furniture and accessories to spruce up your own space!
And today, Apartment Guide is generously offering to give one reader of the Shabby Nest a $100 AmEx gift card...how fun is that?
To enter please leave a comment on this post.
Each entry must have its own comment to be considered valid.
Giveaway ends Friday, July 29 at 11:59 PM MST.
And don't forget to hurry over to Your Picks. Your Place. and vote for your favorite board for a chance to win their sweepstakes!
Disclosure: I was compensated by Apartment Guide for this post.
Great giveaway! Pick me! Pick me!
Great giveaway, hope I win!
How many ways could I spend that?! Thanks for getting us all in-the-know.
I just discovered your site and I love it! It is a visual feast. I see so many ideas that I will be incorporating into my own home and even my hobby, which is quilting.
How exciting that I made this discovery just as you are doing a fun giveaway. I hope I'm the lucky one!
I just liked the apartment guide on FB!
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I need some back to school clothes...I could so use this..thank you apartment guide!!!
I have really enjoyed the voting but I'm sure I'd enjoy this generous prize even more! Thanks for offering this contest.
Wow, what an awesome giveaway!
What a great giveaway! Thanks!
I just voted! Thanks for sharing.
How fun! Those rooms are so adorable!
I've just "liked" the Apartment Guide on FB, too!
How fun! I love ALL the ideas!
OOh!!! What a super fun give-away!!!!!
Exciting giveaway - thanks for the chance to win.
I'm heading right over for the "big" prize. i have deep faith I will win. i always do, but never win. What to do.
Turns out I already do like apartment guide on fb. Who knew.
Hard to choose between them. My mother always says having lots of good choices is the best problem to have.
Thanks for the fun contest tip Wendy. We miss you all tons!!! Our summer plans changed and we won't be going out there. Hope we can visit soon.
Love everything about this! Thank you!!
I love give aways, but never enter!! Hopefully this changes things! Thanks for this chance!
Thanks for the info on the sweepstakes and the generous givaway! Please pick me!!! I could really use the gift card!!!
I would love to win!!
Utah-based Author. Interior Designer. Lifestyle Blogger. Single Mom. I love to share easy, low-cost ideas for making your life beautiful.


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Biohazard, Trauma and Crime Scene Cleanup Services in Hartford, CT
Bio-One is always prepared to remedy situations that arise from unexpected events such as death, traumatic injury, and hazardous situations. We deploy our teams quickly so you can focus on all the other necessary arrangements to begin the healing process.
Facts About Hartford, Connecticut
Hartford is the capital city of the U.S. state of Connecticut. It was the seat of Hartford County until Connecticut disbanded county government in 1960. The city is nicknamed the "Insurance Capital of the World", as it hosts many insurance company headquarters which is the region's major industry. Hartford was founded in 1635 and is among the oldest cities in the United States. It is home to the nation's oldest public art museum (Wadsworth Atheneum), the oldest publicly funded park (Bushnell Park), the oldest continuously published newspaper (the Hartford Courant), and the second-oldest secondary school (Hartford Public High School). It also is home to Trinity College, a private liberal arts college, and the Mark Twain House where the author wrote his most famous works and raised his family, among other historically significant attractions. Mark Twain wrote in 1868, "Of all the beautiful towns it has been my fortune to see this is the chief."
According to the United States Census Bureau, the city has a total area of 18.0 square miles (47 km²), of which 17.3 square miles (45 km²) is land and 0.7 square miles (1.8 km²) (3.67%) is water. Hartford is bordered by the towns of West Hartford, Newington, Wethersfield, East Hartford, Bloomfield, South Windsor, and Windsor. The Connecticut River forms the boundary between Hartford and East Hartford, and is located on the east side of the city.
As of the census of 2010, there were 124,775 people, 44,986 households, and 27,171 families residing in the city. The population density was 7,025.5 people per square mile (2,711.8/km²). There were 50,644 housing units at an average density of 2,926.5 per square mile (1,129.6/km²). The racial makeup of the city was 29.8% white, 38.7% African American or black, 0.6% Native American, 2.8% Asian, 0% Pacific Islander, 23.9% from other races, and 4.2% from two or more races. 43.4% of the population were Hispanic or Latino, chiefly of Puerto Rican origin. Whites not of Latino background were 15.8% of the population in 2010, down from 63.9% in 1970.
Serving Hartford, Connecticut
Bio-One services all types of trauma, distressed property, and biohazard scenes in communities throughout Hartford Area. We partner with local authorities, communities, emergency services personnel, victim services groups, hoarding task forces, apartment complexes, insurance companies and others to provide the most efficient and superior service possible.
We are your crime scene cleaners dedicated to assisting law enforcement, public service agencies and property owners/managers in restoring property that has been contaminated as a result of crime, disaster or misuse.
We have fielded thousands of calls and recovered just about any situation out there in a professional and compassionate matter.
We are Licensed, Bonded, and Insured.
We maintain strict adherence to OSHA rules and regulations to ensure the safety of our workers, the public, and of you and your family.
We are proud to have a great working relationship with the Police, Fire, and most Insurance Agencies.
out of 5 ratings


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Supplementary MaterialsSupplemental Details 1: Supplementary Data files
Written by hiv September 22, 2020
Supplementary MaterialsSupplemental Details 1: Supplementary Data files. Genes and Genomes data source revealed that a lot of of the determined genes had been enriched within the neurotrophin TRK receptor signaling pathway, including MAPK and PI3K/Akt signaling pathway. we noticed that ZBTB38 Muscimol impacts appearance of CDK4/6 also, Cyclin E, MDM2, ATM, ATR, PTEN, Gadd45, and PIGs within the p53 signaling pathway. Furthermore, ZBTB38 knockdown significantly suppresses the expression of autophagy-related crucial genes including RB1CC1 and PIK3C2A. The present reaching provides proof to molecular system of ZBTB38 modulating NB advancement and targeted anti-tumor therapies. and low-quality reads from organic reads. At the same time, Q20, Q30, GC-content and sequence duplication level of the clean reads were calculated. All the downstream analyses were based on clean reads with high quality (Ewing & Green, 1998; Ewing et al., 1998). The clean data of this Rabbit polyclonal to ALDH1L2 article are publicly available in the NCBI sequence reads archive with accession number SRP150042. Comparative analysis The adaptor sequences and low-quality sequence reads were removed from the data sets. Raw sequences were transformed into clean reads after data processing. These clean reads were then mapped to the reference genome sequence. Only reads with a perfect match or one mismatch were further analyzed and annotated based on the reference genome. Tophat2 tools were used to map with reference genome (Kim et al., 2013; Langmead et al., 2009). Reference genome download address: ftp://ftp.ensembl.org/pub/release-80/fasta/homo_sapiens/. Gene functional annotation The assembled sequences were compared against the NCBI nonredundant protein sequences (NR), Pfam, clusters of orthologous groups of proteins (KOG/COG), a manually annotated and reviewed protein sequence database (Swiss-Prot), KEGG ortholog database (KO), and gene ontology (GO) databases with an 0.05) (Fig. 1). However, in the prognosis of these 20 tumors, we only uncover here that low expression of ZBTB38 was associated with improved the prognosis of the brain lower grade glioma (LGG) patients (Fig. 2), suggesting that these changes are closely related to neuronal tumors. Muscimol Open in a separate window Physique 1 Expression analysis of ZBTB38 gene in different tumors based on TCGA database.(A) The expression changes of ZBTB38 gene are closely related to the occurrence of 20 kinds of cancers; (BCE) ZBTB38 expression profiles based on top four cancer stages. ** 0.01. Open in a separate window Physique 2 Effect Muscimol of ZBTB38 expression level on LGG patient survival.Red and blue lines indicated high and low expression groups, respectively. = 0.02 0.05 was considered to be statistically significant. Neuroblastoma cell proliferation and viability after down-regulated of ZBTB38 expression To investigate the importance Muscimol of ZBTB38 in the process of neuronal tumors, three pairs of siRNAs named siRNA1, siRNA2, and siRNA3, were designed to suppress expression of ZBTB38 in human NB cells SH-SY5Y. The protein level of ZBTB38 was decreased significantly ( 0.05) at 24 h after transfection (Figs. 3A and ?and3B),3B), and furthermore, siRNA3 worked best for the suppression. No significant difference in cell proliferation and viability was observed among the initial phases of each group after culture by transient transfection Muscimol ( 0.05). From 12C72 h, the ZBTB38?/? SH-SY5Y group showed significantly lower cell proliferation and viability than the control group ( 0.05) (Figs. 3C and ?and3D).3D). Whereas, a sharp increase in apoptosis of SH-SY5Y cells were observed following ZBTB38 siRNA exposure (Fig. 4A). We next determined the expression levels of pro-apoptotic genes in ZBTB38 knockdown cells compared with knockdown control.
Supplementary MaterialsFigures
The dramatic increase in antimicrobial resistance for pathogenic bacteria constitutes a key threat to human health