I am a Tutorial Fellow in Inorganic Chemistry at Trinity College and a Professor of Inorganic Chemistry in the Department of Chemistry, University of Oxford. I have a BSc and PhD (2001) both from Imperial College London. My PhD studies were supervised by Professors Vernon Gibson FRS and Nick Long and I developed new homogeneous catalysts for olefin polymerization. I was a postdoctoral researcher at the University of Minnesota (2001-02) working with Professors Bill Tolman and Marc Hillmyer on lactide polymerization catalysis. Following this I moved to Cambridge University (2002-03) to work with Professors Andrew Holmes FRS and Richard Friend FRS on organometallic conjugated polymers for light emitting devices. In 2003, I was appointed to the academic staff at Imperial College London as firstly a lecturer (2003), EPSRC Advanced Research Fellow (2005-11), Senior Lecturer (2007), Reader (2009) and Professor of Polymer Chemistry and Catalysis (2012). I moved from Imperial College to Oxford in 2016.
I tutor all areas of Inorganic Chemistry. I also have a large, multi-disciplinary research group in the Department of Chemistry where I supervise students for part II (fourth year UG) research projects and DPhil students. My research team currently comprises 6 postdoctoral researchers and 10 DPhil students.
My research involves making and studying new catalysts and materials, often polymers, for applications such as plastics, elastomers, electronics, medicine and catalysis. My research in polymerization catalysis involves the preparation and study of new metal complexes as homogeneous polymerization catalysis. I am particularly interested in using renewable resources and catalysis to make polyesters, polycarbonates, polyethers and other oxygenated copolymers.
An exciting recent discovery is a series of catalysts that allow carbon dioxide to be used as a raw material to make polymers. The catalysts are efficient under low pressures of carbon dioxide and allow 30-50% of the mass of the polymer to be sustainably sourced. It is even possible to use waste carbon dioxide emissions to make the polymers. The materials may be used as elastomers, adhesives, sealants, coatings and insulation foams. I formed the company econic technologies (http://www.econic-technologies.com/) which has commercialized these catalysts and the technology. Econic technologies is based in London and Manchester and has raised >£13M in funding from various industrial and venture funders.
Another research area concerns the use of plants as raw materials to make oxygenated polymers. Polylactide is a commercial polymer which is sourced from starch, which may be harvested from corn/sugar. I have developed various catalysts that allow polylactide to be produced efficiently and with high control. Understanding how to improve the stereochemical control during catalysis is an important means by which to regulate and improve the thermal/mechanical properties of the material. Research in my team also addresses how to use other carbohydrates, including glucose, as monomers to make degradable polymers suitable for medical applications (in collaboration with Molly Stevens, Imperial College London).
Very recently, I have discovered a new 'switchable' catalysis which allows mixtures of monomers to be efficiently transformed into block sequence controlled copolymers. The catalysts are able to link together various distinct polymerization cycles and can be used to deliver multi-block copolymer efficiently. The copolymers produced using this new method show properties suitable for application as elastomers or rigid plastics. We are currently studying in detail the self-assembly and applications for these block copolymers. In collaboration with Alexander Bismarck (university of Vienna) we have investigated the preparation and properties of various composites which comprise renewable polymers and cellulose as the structural directing agent.
My research in nanoparticles includes developing new means to make, characterize and applying them in polymer composites, as catalysts or in electronics. This area of research is carried out in collaboration with Prof. Milo Shaffer (Dept. Chemistry, Imperial College London). We have developed various organometallic methods to prepare ZnO and doped ZnO nanoparticles – the synthesis operates in organic solvents and at room temperature and allows the preparation of small (3-4 nm) particles with high crystallinity and surface coordinated ligands. The nanoparticles have been used as fillers in various polymer composites for both commodity and electronic applications. We have also led a multi-disciplinary project investigating the application of colloidal nanoparticles of ZnO, Cu and other metals as catalysts for carbon dioxide reduction to methanol. The application of colloidal nanoparticles, both metals and metal oxides to various gas to liquids transformations, particularly as relevant for the production of fuels is an on-going research interest.
Overall, my research areas include preparing, characterizing and applying polymers and materials for a range of uses. I have enjoyed a range of different industrial collaborations and am motivated by applied research challenges. I also have a network of academic collaborators and am interested in fundamental problems related to catalysis, kinetics and polymer chemistry.
1.	Pike S, White E, Shaffer M, Williams CK, Simple Phosphinate Ligands Access New Zinc Clusters Identified in the Synthesis of Zinc Oxide Nanoparticles, Nature Communications, 2016.
2.	Romain, C.; Zhu, Y.; Dingwall, P.; Paul, S.; Rzepa, H. S.; Buchard, A.; Williams, C. K., Chemoselective Polymerizations from Mixtures of Epoxide, Lactone, Anhydride, and Carbon Dioxide. J. Am. Chem. Soc. 2016, 138 (12), 4120-4131.
3.	Thevenon, A.; Romain, C.; Bennington, M. S.; White, A. J. P.; Davidson, H. J.; Brooker, S.; Williams, C. K., Dizinc Lactide Polymerization Catalysts: Hyperactivity by Control of Ligand Conformation and Metallic Cooperativity. Angew. Chem. Int. Ed. 2016, 55 (30), 8680-8685.
4.	Zhu, Y.; Romain, C.; Williams, C. K., Selective Polymerization Catalysis: Controlling the Metal Chain End Group to Prepare Block Copolyesters. J. Am. Chem. Soc. 2015, 137 (38), 12179-12182.
5.	Garden, J. A.; Saini, P. K.; Williams, C. K., Greater than the Sum of Its Parts: A Heterodinuclear Polymerization Catalyst. J. Am. Chem. Soc. 2015, 137 (48), 15078-15081.
6.	Chapman, A. M.; Keyworth, C.; Kember, M. R.; Lennox, A. J. J.; Williams, C. K., Adding Value to Power Station Captured CO2: Tolerant Zn and Mg Homogeneous Catalysts for Polycarbonate Polyol Production. ACS Catalysis 2015, 5 (3), 1581-1588.
7.	Bakewell, C.; White, A. J. P.; Long, N. J.; Williams, C. K., Metal-Size Influence in Iso-Selective Lactide Polymerization. Angew. Chem. Int. Ed. 2014, 9226 –9230.


A Morenci man was pronounced dead on the scene of a two-vehicle traffic accident early Monday morning.
Leonard Adam Dietrich, 58, of 516 Whitney Ave., was driving a 2008 Dodge Ram pickup truck westbound on Territorial Road when the accident occurred at about 4:12 a.m.
According to the report by the Hillsdale County Sheriff Office, Dietrich crossed over Pioneer Road (M-99) in Amboy Township and was struck by a southbound Plymouth Voyager minivan driven by Larae Marie Hegeman, 39, of Hillsdale.
Dietrich's vehicle rolled several times before coming to rest on its roof. He was wearing a seat belt at the time of the crash.
Hegeman was transported by emergency helicopter to St. Vincent Hospital in Toledo. A 16-year-old passenger was taken to the Hillsdale Community Health Center.
The accident still remained under investigation as of Tuesday morning.


I am so appreciative of all the hours of hard work and effort you put in to making my dreams of having a place to call "Home" a reality. I did not think this would ever happen for me. Thank you so much for everything you have done for me. I highly recommend Roz to all who are looking for a great realtor.


This report is taken from PN Review 207, Volume 39 Number 1, September - October 2012.
In 1951, Ceri Richards was one of the sixty 'distinguished artists' invited by the Arts Council to contribute to an exhibition for the Festival of Britain, an event affectionately remembered at its fiftieth anniversary last year. (I doubt it will be possible to say the same about the excruciating Millennium Dome.) As his subject Richards chose Trafalgar Square, a great hub loaded with symbolism that he knew very well, because by that time London had been his home for twenty-five years. He filled a book with sketches and produced not one, but a series of large oil paintings in which he isolated and reassembled the familiar features of the square. The paintings are vibrant with colour and movement, scintillant with light. They are modernist paintings.


text:
Warren Buffett and The Washington Post Company
Warren Buffett announced today that he will not be seeking re-election to the Washington Post Board of Directors at its annual meeting in May. Buffett has served on the Post's board for 26 of the past 37 years. His company, Berkshire Hathaway, is the largest outside shareholder, holding 1.73 million shares which represent approximately 21% of the Post's class B shares. The shares closed today on the New York Stock Exchange at $433.25, valuing Berkshire's stake at $750 million. Over time , Buffett has served on the Boards of Directors of 19 firms. After he steps down from the Post's board, Buffett will be on the board of only Berkshire Hathaway, where he is the chairman and chief executive officer. Buffett was quoted by the Wall Street Journal as saying: 'We're going to keep every share of stock we have. I would never sell a share of the Post".
As a guest speaker at the Robert H. Smith School of Business at the University of Maryland on October 20, 2009, Don Graham, Chairman of the Board and CEO of the Washington Post Company reminisced about the long and extremely fruitful relationship both he and his mother, Katharine Graham, have had with Warren Buffett dating back to 1974.
Don Graham's comments included the following:
In 1974, when the stock market was at a once in a generation low ("similar to March 2009"), Warren Buffett bought 11% of the Post's shares because the value of the Post's assets far exceeded its market value. Buffett then sent a letter to Katharine Graham informing her of his purchase. Since she had not heard of Warren Buffett, she immediately tried to find anything she could about him. Ms. Graham then flew out to Omaha to meet with Buffett and his associate Charlie Munger. When she returned, she said they were the two smartest people she had ever met and wanted Buffett on the Post board of directors. Buffett has been on the Post board from 1974 to 1986 and from May 1996 to now.
Whenever Katharine Graham or Don Graham have needed advice on difficult decisions, they have reached out to their board of directors and have contacted them prior to regularly scheduled board meetings. Buffett is the "lead director" and is contacted first and more often than the other directors. Buffett over the years has given invaluable advice to both Katharine and Don Graham, which has included:
(1) The primary responsibility of a CEO is to allocate capital.
(2) When the Post was substantially undervalued in the mid-1970's, Buffett recommended the Post buy back its stock, which it did. (The number of outstanding shares was reduced substantially such that Buffett's original 11% investment today represents 21% of the Post.)
(3) Buffett recommended that the Post's defined benefit pension plan be invested with one or two outstanding investment managers instead of with another manager where a majority of corporate pension funds were being invested and earning average market returns in the 1970's. The Grahams accepted Buffett's advice. Don Graham mentioned that the Post has not had to make any additional contributions to its pension plan since then, and he estimated that the Post has saved over $1 billion as a result. According to Buffett, a strong pension plan where you do not have to inject capital every year is like having another strong business within the company.
Buffett also taught the Grahams the importance of patience with respect to mergers and acquisitions. Most mergers do not work out. It is important to wait for the right opportunity. For example, Don Graham mentioned that in the fall of 2008 Buffett invested $5 billion in Goldman Sachs 10% perpetual preferred and warrants. He receives $500 million per year in dividends and has created $2.5 billion in value for Berkshire shareholders (based on the value of Goldman Sachs warrants at that time). "Warren Buffett was sitting on $30 billion of cash waiting for the right opportunity."

redpajama_set_name: RedPajamaCommonCrawl


text:
Q: Relation with pivot table I've three tables and I would like to use pivot table data when getting results.
These tables are products, store, store_products, cart_items and their fields are below:

*

*products (id, name, price)

*store (id, name etc.)

*store_products (store_id, product_id, store_price, store_slug)

*cart_items (id, user_id, product_id, store_id, quantity)
My CartItem model is like
class CartItem extends Model
{
    public function product()
    {
        return $this->belongsTo('App\Product');
    }

    public function store()
    {
        return $this->belongsTo('App\Store');
    }

}

When I call CartItem::with('product')->get(), I would like it to return product data (from product table and store_price, store_slug from store_products) with matching cart_items.store_id and cart_items.product_id from pivot table "store_products".
How can I create this relation by on my CartItem model? If possible, by just using Eloquent ORM functions instead of query builder or raw queries.

A: In products Model add,
public function stores(){
    return $this->belongsToMany(Store::class)->withPivot('store_price', 'store_slug');
}

In Store Model add,
public function products(){
    return $this->belongsToMany(Products::class)->withPivot('store_price', 'store_slug');
}

Then call,
CartItem::with(['product.stores'])->get();

For more explanation read this article:
http://laraveldaily.com/pivot-tables-and-many-to-many-relationships/

redpajama_set_name: RedPajamaStackExchange


Dandan and her teachers make engineering and science so much fun with lots of hands on activities that the kids absolutely love! Then there is actual learning too, my 9 yr old has completed mechanical engineering, aeronautical engineering and robotics with EFK and he really absorbed all the science terminology that were being taught. Well done EFK!
A special thanks to Dandan and her team for organising a wonderful, fun and educational Vex Robotics School holiday workshop. Ronan had such a great time building and coding different types of models. It was very hands on with the right amount of guidance to challenge and encourage his love of building and the science behind it. Already, he is looking forward to attending the next school holiday camp. We highly recommend this workshop!


A Different Side of Hamburg: The Elbphilharmonie sits on the Elbe Rive in Hamburg. Taken on a night cruise, the light and reflections make the beauty of the building stand out.
Berlin Remembrance: Taken at Bebelplatz, the window in the ground stands for a memorial to the books burned throughout the various universities during World War II. To me, the reflections of the people looking down also shows us reflecting on what happened during that time.
Color in History: Taken in Hanover, the older historical buildings stand out among the newer sections of Hanover. The buildings are very colorful and stand out among the streets.
In A Fairytale: We adventured to a small town near Koblenz, called Winningen. It is beautifully set among the mountains with grapevines. The town is made of mostly cobblestone streets and picturesque views.
Living in a Painting: During the Red Thread Trail in Hanover, we discovered the Leine River running through the middle of town. I felt like I was living in an impressionistic painting when we walked along side of it.
BIO: Artist Alexandra Ridinger is from the South Jersey/Philadelphia Metro area. She is a certified K-12 Art Teacher in New Jersey where she teaches Fine & Digital Art Teacher in Haddon Heights, New Jersey with grades 7 through 12. She also work as a photographer and a freelance graphic designer in her spare time. She lives with her fiancee and two cats, Butters and Suki. This was my first time outside of continental North America, first time flying over the Atlantic. I got a sense of Wanderlust going to Germany and I can't wait to travel more of the world!


Our ongoing series aimed at bringing you closer to the business side of the sports nutrition industry continues as DigitalMuscle.com shines a spotlight on a member of the team at RedCon1, one of the world's fastest growing supplement brands. The selected employee has been chosen by the company's CEO and is being showcased here at the Fitness Industry's Media Hub. The Employee Spotlight for the month of June belongs to RedCon1 Chief of Staff Eduardo Silva. Join us in congratulating Eduardo and get to know him in this brief Q&A.
Can you give us a short description of your responsibilities?
I handle all personnel issues. Hiring, firing and any other issues that may arise amongst the staff. My other duties involve coordinating and booking all travel for every event we do, maintaining relationships with our payment processors, filing trademarks for products, and I am also in charge of approving and purchasing for our apparel line. And finally, I handle CEO Aaron Singerman's personal affairs.
My favorite part of my job is traveling the world and seeing the amazing response every one has towards the brand. Having been here since literally the first day it came into existence, there's a real sense of pride that comes with hearing all the great things people say about RedCon1.
I learned that I have a better work ethic than I ever thought. Never in my life would I have imagined being glued to my phone or computer at all times of the day with work, but now I do it and it never feels like work. It comes with the territory of being around Aaron 10+ hours a day, it becomes part of you, just ask my wife!
Tell us about your current training goals and progress in the gym.
Currently I'm in a maintenance mode. Recently I lost 20 pounds during our transformation challenge, I'd like to buckle down and lose another 20-30 and assess from there.
Before I train I take our Total War pre-workout, Big Noise, MOAB, and Grunt. Throughout the day I'll take Halo, Med Kit, Silencer, and MRE Lite. I believe in every product we offer here at RedCon they play a big part in helping me reach my personal goals.
What are you current career goals?
My career goal is more of a company goal. I want to see us become the biggest supplement company in the world. It's not a matter of IF but WHEN. I am currently third in command of the whole company so it's not too shabby!
Final question: With so many choices, why should someone choose RedCon1 for their supplement needs?
Someone should choose us because our products do what they say they do and are the highest quality in the industry today. Also our brand message and marketing is one that you could show to any member of your family. We want our customers to feel like they are part of something bigger than just another company selling them a product, our customers are part of our family.


My boyfriend & I just took a road trip from Northern California to Austin, Texas and along the way we drove thru Arizona. I had never visited Arizona before and was extremely excited to see the saguaro cactus & gorgeous desert landscape! I instantly had the idea to make a cactus skirt for the occasion! I drew inspiration from vintage tourist items, especially the Mexican tourist jackets!
Before i cut the cactus out of felt, i drew on my skirt with chalk to get a basic idea of the layout.
Next, I drew the shapes of the cactus on my felt with chalk & cut them with a rotary cutter.
Then, I pinned my cactus to the skirt over my chalk layout & began to blanket stitch them to the skirt. This was very time consuming, but also very relaxing.
Finally, I added some details to each cactus by top stitching with my embroidery floss.
Here are some finished shots!! I just loved wearing my skirt in Arizona! Some of these photos are taken at the Hotel Congress in Tucson, AZ…if you haven't been there, i highly recommend it! It is decorated in an art deco southwestern theme & the rooms are as they were in the 1930s..amazing!
I can't wait to use this technique for another project!
I decided to give these shorts a go, since I've always loved the look of high waisted shorts but don't actually own any! Im usually NOT a shorts person, but these have converted me! They were easy to sew up & came together quite quickly (which i know we all love!).
I chose a light weight wool in dark brown that i had laying around & even added a personal touch by hand embroidering a little bow design on the waistband!
Here are some photos of the finished product! Im quite happy with how they came out & it just so happened to be a nice warm day here in Berkeley…perfect for my new shorts' debut!!
I highly recommend these shorts to all of you gals who are looking for nice summer patterns…they're great!


ERSIN AKARLILAR worked in company SAFF INVESTMENTS LIMITED	as COMPANY DIRECTOR.
ERSIN AKARLILAR was from 2001.12.19 to 2007.12.20 at SAFF INVESTMENTS LIMITED employed as Director (COMPANY DIRECTOR).
ERSIN AKARLILAR Score for ERSIN AKARLILAR is 2.5 stars.


I kid. I'm only Beyoncé in my dreams.
God help me when it's time for grad school.
In honor of this hellish student rite of passage, I'm going a bit Buzzfeed-y this time around, and getting real about finals week, listicle style.
What's the nutritional value of three Red Bulls and whatever's left in the vending machine? Whatever it is, it got you that semi-relevant 8 page research paper that may or may not have spelling errors you stopped caring about long ago.
Bonus points if they're also engineering or architecture majors because... how?
It's every man for themselves. You could be holding the winning lottery ticket outside of Hale and I'm still not moving from my spot. But if you have the answer key, by all means hit me up.
I'm either a genius or I've colossally screwed up. Which one is it?!
5. ...or get B for five answers in a row.
Five in a row? Oh no!
6. You've become a pro at napping in the most obscure locations.
7. You start questioning all of the choices in life that led you to this moment.
What if I'm not meant to be in this major? What if I'd be better off as a lonely sheep herder in Iceland? Do they even have sheep? Oh God, what am I doing?!
8. You hope the person you admire is watching you struggle.
9. And when all is said and done, you feel like you just defeated Lord Voldemort.


text:
About NootropicsProfessor.com
Natural Nootropics
Where to Buy Nootropics
How to Upregulate Dopamine Over the Long-Term
June 8, 2019 March 15, 2020
Brain Health, Nootropic Stacks
For this post, I want to discuss an idea that is rather nuanced and complex: how to chronically upregulate dopamine (DA) levels.
You can find hundreds of articles on "how to boost dopamine", but this is only half the story. In reality, it's not as simple as merely boosting a neurotransmitter and expecting a positive result.
In order to explain this distinction, I will need to provide a brief overview of some key brain mechanisms, namely homeostasis and synaptic transmission. If you want to skip ahead you can feel free to do so, but this information is worth knowing.
A Brief Lesson in Neurochemistry
Methods of Upregulation
Sunshine Exposure
The image above is a simplified illustration of synapse, which is connection between two nerve cells (neurons).
The brain contains about 100 billion neurons, and neurons are connected to one another in a complex web of synapses. There are over 100 trillion synapses in the brain, and each one is used to send and receive chemical signals from neurons.
Neurotransmitters are created and stored in pre-synaptic neurons as seen at the top of the illustration. Once released, they are absorbed by the post-synaptic neurons as seen at the bottom.
Both pre-synaptic and post-synaptic neurons contain receptors that regulate how much a neurotransmitter is released and how much it is absorbed. When DA is flooded into a synapse, it will "vacuum up" any excessive DA back up into pre-synaptic receptors.
Drugs like cocaine work preventing this "vacuuming" effect (typically by blocking the action of a transporter called DAT). This process is commonly referred to as reuptake inhibition. Antidepressants like Zoloft and Prozac share this mechanism, but act as serotonin reuptake inhibitors instead.
The brain is constantly trying to maintain homeostasis: a stable, steady state of equilibrium. If you abuse a drug like cocaine, your brain will be constantly flooded with unnaturally high amounts of DA. Your brain will recognize this, and will respond by downregulating the amount of post-synaptic receptors, decreasing your sensitivity to DA.
In reality, these neurological processes are much more complex than this, but this will give you a general idea of how homeostasis works. Many people who are familiar with these basic concepts will understand the limitations of trying to raise DA levels.
These feedback mechanisms partially explain why drugs like cocaine are so addictive. Once the effects of the drug wear off, repeated doses will be required to maintain high levels of DA. Over time, baseline DA levels will decrease due to this downregulating effect.
These self-correcting steady-state mechanisms of the brain are not limited to drugs of abuse; the brain is constantly making adjustments to maintain a consistent state, from even the most trivial of activities.
Fortunately, there do appear some effective ways of increasing average DA levels over the long-term. This list will include both supplements and physical tasks; I will attempt to explain the mechanisms behind each in relationship to this goal.
Uridine is a naturally-occuring nutrient and nootropic that is critical for brain function. It is ubiqitous in nature as it used to form RNA in the brain and is produced in the bodies of all living creatures.
Uridine works by repairing dopaminergic neurons and preventing overstimulation in the striatum.1https://www.ncbi.nlm.nih.gov/pubmed/83720962https://www.sciencedirect.com/science/article/pii/009130579500169W3https://www.ncbi.nlm.nih.gov/m/pubmed/2050447118https://www.ncbi.nlm.nih.gov/pubmed/2906500
By preventing overstimulation of striatal DA receptors, uridine may help promote more stable and consistent levels of circulating DA in the brain.
Accordingly, uridine has been shown to enhance DA release through potassium channels. In rats, striatal DA levels were measured after 6 weeks of supplementation. DA release was shown to be significantly higher in treated rats; the treatment group had basal DA levels of 341+/-21%, while the control group had basal DA levels of 283+/-9%.4https://www.ncbi.nlm.nih.gov/pubmed/16055952 This measurement was seen after both 1 and 6 weeks of supplementation.
Taken together, it would appear that uridine may upregulate DA by both preventing excessive DA levels and by repairing/restoring neuronal DA functionality.
Buy Uridine at Pure Nootropics
CDP-Choline, also called citicoline, is a naturally-occuring compound and nootropic that is typically supplemented to improve cognitive performance.
In one study, CDP-choline was provided to aged rats over the course of seven months. After seven months, levels of striatal DA were measured. In the one treated group, a dose of 100mg/kg was used, and an 11% increase of DA receptor densities was found. In the another treatment group, a dose of 500mg/kg was used, and this time a 18% increase was found.5www.ncbi.nlm.nih.gov/pmc/articles/PMC1908237/
Interestingly, a third group received no citicoline at all, and they showed a 28% decrease in receptor density. This is because DA receptor densities decrease with age, at a rate of about 3% per decade.6https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1991.tb12471.x
The exact mechanism by which cdp-choline upregulates DA is unclear. However, CDP-choline does provide neuroprotection for dopaminergic neurons7https://www.tandfonline.com/doi/abs/10.1080/10623320600934341, and this protection play a key role.
It should be noted that the differences between the treatment groups and the nontreatment group was quite significant. Additionally, given that rat lifespans are quite short, 7 months is quite a long time, which suggests these changes may be permanent.
Buy CDP-Choline at Pure Nootropics
Forskolin is an herbal extract that is touted for many alleged health benefits. It has many interesting properties that warrant further research, but one of the lesser-known properties of the plant is its effect on DA receptors.
Forskolin has been noted to upregulate DA receptor densities quite significantly. In the first study I will be referencing, supplementation was shown to modify two unique DA receptors: D2L, and D2S.
D2L: a "long form" post-synatic receptor, which allows DA to get absorbed and utilized
D2S: a "short form" pre-synaptic receptor, which regulates DA synthesis, storage, and release
In regards to receptor densities, forskolin increased D2L receptor densities by 43%, and increased of D2S receptor densities by 107.5%.9http://www.ncbi.nlm.nih.gov/pubmed/9353595
In short, what this study suggests is that the brain:
Becomes sensitized to DA by increasing its availability to be absorbed
Becomes more effective at regulating DA release, which may maintain stable DA levels over the long-term.
In the next study, rats were directly injected with forskolin into their cerebrospinal fluid for 5 days. Afterwards, it showed the same results as the previous study; increases in both the post and pre synaptic densities. Interestingly, D1 receptor densities were decreased.9http://www.ncbi.nlm.nih.gov/pubmed/9353595
In this third study relating to forskolin supplementation, similar results were found. In rats, D2L receptor densities were increased by 43-96%, which indicated DA supersensitivity.13https://www.sciencedirect.com/science/article/pii/0922410694900817
The results of this are a bit more ambiguous, especially in regards to the ratio of receptor changes. However, as the 3rd study indicated, it would appear that forskolin does in fact lead to DA sensitization in the brain through modulatory effects on DA receptor densities.
Buy Forskolin at iHerb
Inositol, also referred to as Vitamin B8, is a molecule that is structurally similar to glucose. It is critical for cellular signalling in the brain and facilitates communication between neurons.
Inositol is considered a pseudovitamin, as inositol is metaboized in the kidneys from glucose. However, it may be a key nutrient in regulating mental health, and deficiencies have even been implicated in schizophrenia.14https://www.ncbi.nlm.nih.gov/pubmed/1352895
There is some emerging evidence that suggests inositol may be able to elevate DA levels over a long period. One notable study was conducted recently to determine the effects of inositol on mental health by analyzing its effects on various neurotransmitters.
In this study, guinea pigs were given oral inositol (1.2 g/kg) for 12 weeks (about 15-20g a day for humans). The result were promising: chronic inositol induced a significant increase in striatal D2 receptor density.8https://www.ncbi.nlm.nih.gov/pubmed/11267629 There was no data on whether this effect is maintained after treatment nor the degree to which the densities were changed depending on dosages used.
Inositol is known to be a key signalling agent for neurotransmission, which may be enhanced by regular supplementation. As such, upregulation may occur in part due to the increased cellular communication.
Buy Inositol at iHerb
Lately, the mental health benefits of exercise are gaining a lot of traction. There is now an increasingly large amount of evidence that exercise can increases DA receptor availability in the striatum.11https://www.ncbi.nlm.nih.gov/pubmed/26503310
In one study, exercise was shown to reduce the neurological damage that occurs from methamphetamine abuse. Adult men and women with methamphetamine dependence were given supervised exercise therapy while recovering. After exercising for three days a week for 8 weeks, the treatment group showed a significant increase in striatal D2/D3 function.11https://www.ncbi.nlm.nih.gov/pubmed/26503310
One rat study showed similar results. Rats were subjected to eight weeks of a food-reinforced running-wheel exercise. Levels of DA were noted to be upregulated after the eight week period, although a compensatory downregulation of the receptor densities was also noted.12https://www.mdpi.com/2076-3425/3/1/39/htm
The upregulatory effects of exercise on DA levels does not not appear come from modulating receptors. Rather, it was found that DA binding affinity was increased.12https://www.mdpi.com/2076-3425/3/1/39/htm
Additionally, this study suggested that exercise training upregulated DA by increasing levels of serum calcium. This is because the enzyme responsible for DA synthesis (tyrosine hydroxylase) is partially mediated by calcium influx in the brain.
It's unclear which form of exercise is most effective. A mix of weight training, HIIT, and cardio is generally a safe bet.
Here's another behavioral change you can implement to increase DA sensitivity. In this study, the goal was to identify the correlation between sunshine exposure and DA levels. This was accomplished by comparing 68 volunteers who had either high levels of sunlight exposure or low levels sunlight exposure.
The study found that striatal D2/D3 receptor availability was significantly greater in the group with high exposure than the low exposure group. This was even after controlling for age, sex, and smoking status.20https://www.ncbi.nlm.nih.gov/pubmed/20875835 Furthermore, this does not appear to be related at all to Vitamin D levels. This means that sunlight is not only essential for synthesizing vitamin D in the body, but also for dopaminergic regulation.
While scientific evidence on meditation is still in its infancy, there is emerging evidence of many incredible benefits to brain health and function. There are two studies which show that meditation modestly increase DA levels, although effect did not appear permanent unless it was practiced regularly.15https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3044190/16https://www.ncbi.nlm.nih.gov/pubmed/11958969/
One very interesting study measured spontaneous eyeblink rates, which is strongly correlated with striatal DA activity. Here, the authors stated that meditation has been shown to affect cognitive functions such as mind wandering, cognitive flexibility, and attention. These cognitive functions, in turn, were shown to be correlated with eyeblink rates as well.
The goal of this study was to determine the effects of long-term meditation on eyeblink activity; the results of which can be used to infer the effects on striatal DA levels.
Both long-term meditators and new meditators were examined over 8 weeks of a mindfulness-based stress reduction course. The long-term meditators were found to have blinked less often and had a different pattern from the the new meditators.17https://www.ncbi.nlm.nih.gov/pubmed/26871460
The study concluded that "long term meditation practice induces stable changes in baseline striatal DA functioning."17https://www.ncbi.nlm.nih.gov/pubmed/26871460
The authors mentioned that individual differences in DA function may have acted as a self-selection factor in meditation practice. In other words, people with specific DA levels are more likely to practice meditation. While this is a possibility, I find it very unlikely that this accounts for every individual case. More studies are urgently needed.
https://www.sciencedirect.com/science/article/pii/009130579500169W
https://www.ncbi.nlm.nih.gov/m/pubmed/20504471
www.ncbi.nlm.nih.gov/pmc/articles/PMC1908237/
https://bpspubs.onlinelibrary.wiley.com/doi/pdf/10.1111/j.1476-5381.1991.tb12471.x
https://www.tandfonline.com/doi/abs/10.1080/10623320600934341
https://www.mdpi.com/2076-3425/3/1/39/htm
https://www.sciencedirect.com/science/article/pii/0922410694900817
14 thoughts on "How to Upregulate Dopamine Over the Long-Term"
Chelsea June 30, 2019 at 8:50 am
The meditation, excersise and b8 didnt give any actual data for the increase which leads me to believe receptor density increase by these methods are negligible. The herb was shockingly good I take daily doses of tianeptine sulphate and CDP form of choline,will probably add in forskolin and uridine but these have made a big difference in motivation energy mood and focus so I can vouch for a few of these.
Patrick November 8, 2019 at 10:09 am
thank you for the informative and well-researched article.
Would you advise using all these strategies together (obviously uridine and choline; yes)?
These strictly have to do with the upregulation. So things like Memantine and huperzine A don't fall into that category because they; as I understand it – are used to ward off tolerance if one uses ADD medications.
How about Bromantane and Pregonole?
Do upregulation and tolerance avoidance go hand in hand? Or do you have to choose between one or the other?
Can you just throw everything in there or is that a BIG NO NO!!:)
Jacob November 17, 2019 at 12:41 am
Hi Patrick
I would suggest staying away from memantine period, it's a very complex drug and it's really not worth taking just to reduce tolerances to other substances. Bromantane is interesting, it's unclear whether its a safe and reliable way of upregulating dopamine but I may do some more research and see if it belongs on this page. The other two you mentioned don't really fit in here, overall tolerance and upregulation are two totally seperate processes.
But in short, yes in theory you could start taking all the compounds in this post. The only problem is that it will be harder to figure out the optimal doses for everything if you're taking it all at once. The biggest risk you have might come from excessive uridine or cdp choline, which can cause flat moods as they both raise acetylcholine quite a lot as well.
Dan November 14, 2019 at 8:27 pm
Chelsea, what herb are you talking about? "The herb was shockingly good"
She must have been talking about the forskolin extract.
Pietro December 4, 2019 at 10:30 am
You say long term but there haven't really been any long term studies on humans with these compounds right? I'm curious what makes you think that for example the inositol induced increase in dopamine receptor density will stay after you stop taking inositol. Or do you have to keep taking it?
Jacob December 7, 2019 at 8:14 pm
My theory, and perhaps I should have explained this better, is that these changes last indefinitely as long as you keep taking the supplement(s). I do think in some sense that you can consider these effects permanent even if it requires continued supplemention. In the case of most if not all of these supplements, the upregulation that occurs seems to "stick" so long as you keep taking them ie your new baseline DA levels will stay higher than your previous baseline levels. That said I do think some of the supplements may induce lasting changing even upon cessation, uridine for instance actually repairs dopaminergic neurons and that in and of itself is a long-lasting effect.
Patrick March 1, 2020 at 7:32 pm
Dear Jacob,
Would it make sense to put together a preformulated stack based on your suggestions, minus 'tia' that is? And what would it look like assuming it is safe and without adverse effects? Let's say a dopaminergic maintenance stack if one was on prescribed, ADHD meds at therapeutic doses. For this, thas or the other reason my medication stops working once in a while almost overnight. I always panic as I'm a professional writer and can't get a decent amount of work done without my meds. And I'm not talking about 8 hours of cranking out storylines. I'm much calmer now then I used to be, I accept it and try to tell myself, maybe in a couple of hours. Otherwise, the worry spirals out of control, turns into anxiety. I eat (and cook) healthy, sleep enough, take long walks every day (not running, but not walking either:). But on some level, it would help to know I'm attending to my dopaminergic hygiene.
I already take a stack with Alcar, NALT, and P.S. three times a day. More or less based on a colleague of yours. And some amino acids as well. Or is the whole idea os synergy between several of the substances you described rubbish? It's just scary when that happens. Any advice would be much appreciated.
Jacob March 18, 2020 at 5:24 pm
I would think taking all of these supplements at once is fine and I doubt it would increase the risk of side effects. With tianeptine gone now, you're basically left with uridine/cdp choline, inositol, and forskolin. Of those, the only one with notable side effects is forskolin, so I might suggest being more cautious with that. The issue with taking numerous supplements all at once is that it's hard to fine-tune them to figure out the optimal dosage for you, plus it can be hard to pinpoint which substance is working for you and which isn't. I would start with uridine and/or cdp-choline to see how you react to them. After that I would incorporate inositol and eventually forskolin. I should note I have not actually tried forskolin myself, but I will be sometime soon. I'm still trying to adjust to the 20g a day of inositol which does have some annoying GI discomfort.
rico March 18, 2020 at 12:04 pm
So what's the best strategy? If you can't do everything at once?
Pick one? Skip Inositol because you need to take so much?
or a combo or trio?
I would strongly suggest starting with uridine and/or cdp choline at smaller doses and work your way from there. You could add in inositol to that pretty soon but I would suggest working your way up to the full 18-20g daily dose as that can cause a bit of GI discomfort.
atlast April 9, 2020 at 2:55 pm
Hi all, several years ago I collected a lot of research and notes about neurotransmitters and it's modulators. I've lost them and now I'm trying to recollect them once more, so I came across this page. I would like to give some food for thought: uridine and citicoline are probably redundant, because supplementation of one increase the other; the oral dosage for citicoline for a person of 75kg would be of about 1000mg, but as I know, sublingual administration increase bioavailability by a factor of 4-5, so the sublingual dosage shoud be 200-250mg to achieve 11% increase in D2 receptors (I don't think that it is worth trying to achieve the 18% increase, because to less than double the dosage you have to increase dosage by a factor of five); even if percentage of receptors increase with inositol is not reported, I don't think is negligible, because at high dosage it has the same efficacy of SSRIs for OCD and there are studies that reports a noticeable increase in SSRIs for OCD; about forskoline I don't have a reference on dosage, but it worried me more than others supplements due to the risk of developing mania (inositol don't increase responsiveness to amphetamine like substance, while forskoline does).
And last, I would cite the use of ultra low dose antipsychotic.
Sam April 16, 2020 at 11:12 am
Hi Jacob,
First off thank you for this wonderful article.
Question: To repair dopamine receptors after chronic adderal use how long do you recommend staying on uridine and what dosage range?
Jacob April 24, 2020 at 4:55 pm
I would start on the low end, perhaps 100mg per day, and slowly work up 50mg a time and see how you feel. There is no universally accepted dosing regiment for uridine, it varies with the individual.
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Jacob on How to Upregulate Dopamine Over the Long-Term
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atlast on How to Upregulate Dopamine Over the Long-Term
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text:
How new biomolecular platforms and digital technologies are changing R&D
July 30, 2018 | Article
By Olivier Leclerc and Jeff Smith
Article (PDF -824KB)
By going digital, biotech pioneers with promising biomolecular platforms are improving drug discovery and development—and changing the pharmaceutical industry.
Article (PDF-824KB)
The use of digital technologies is transforming business as usual in industries ranging from aviation to retail to telecommunications. But other sectors—including the pharmaceutical industry—have been slower to embrace the potential of digital technology.
Given that pharma companies depend on innovation, science, and research and development, it may seem counterintuitive that they lag behind the digital curve. In McKinsey's ongoing survey to measure companies' "Digital Quotient," the pharmaceutical industry ranks in the bottom third of industries measured. But consider the context: pharma is characterized by long, capital-intensive product-development cycles, and considerable technical and regulatory uncertainty. As a result, there is a degree of risk aversion.
A new breed of biotechnology firms, unencumbered by the accumulated practices and systems of large traditional ones, are pioneering impressive new digital capabilities. In the process, they are nudging the industry as a whole in this direction. This could significantly boost R&D productivity, benefiting both pharmaceutical companies and the patients they serve.
The emergence of biomolecular platforms
In recent years, a number of biotechnology companies have applied genetic-information-driven technologies to form "biomolecular platforms" (exhibit). These platforms intervene at different points in the information chain (often referred to as "the central dogma of biology") to modify biomolecular processes at the source of various diseases. In that respect, they have a software-like nature, that allows for the ready design of multiple new therapies by a single platform, that provides the instructions to modify the hardware of molecular biology, that in turn addresses disease.
Biomedical platforms have already yielded new treatments—spanning various DNA-, RNA- and cell-based therapies—with broad potential applications. Many of these new interventions offer a glimmer of hope for treating life-threatening diseases that have so far proved impervious to conventional approaches, such as small molecules or monoclonal antibodies.
Indeed, several such therapies have already received regulatory approval: of particular note are the US Food and Drug Administration's (FDA) recent green lights for Kymriah and Yescarta. These are chimeric-antigen-receptor therapies (CAR-T) for certain aggressive hematological malignancies. Similar CAR-T therapies are advancing rapidly. Luxturna, which treats a rare form of inherited vision loss, recently became the first FDA-approved DNA gene therapy. In addition, several antisense drugs have also been approved. These examples account for only a small number of the biomolecular-platform-derived therapies that are working their way through the pipeline and rapidly approaching the market.
Biotech companies have raised significant amounts of capital to advance biomolecular platforms and their associated development programs. According to our analysis of data from BioCentury, a biotechnology review, at least five have each raised more than $1 billion in capital. Fundraising has accelerated rapidly over the past five years; all told, as of the end of 2017, 100 companies have raised at least $13 billion over the past several years to discover and develop biomolecular platforms.
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Biotech companies are typically formed around their unique insights into the underlying disease biology for a single disease or a related cluster of diseases. For these companies, the nature of drug discovery and development remains mostly unaltered from the recent past. Many have adapted by focusing on specialty-disease areas where few treatments exist; this allows them to make use of expedited development and regulatory pathways that could lead to reduced timelines and costs and increased probability of success.
Interview: How Moderna uses its digital capabilities to power its mRNA platform
Founded in 2011, Moderna Therapeutics has built a messenger RNA (mRNA) platform that is designed to accelerate the discovery and development of mRNA therapeutics that treat a range of diseases with high unmet needs. In this interview, CEO Stéphane Bancel discusses how Moderna uses digital technologies in its mRNA platform.
McKinsey: Moderna has brought drugs into the clinic across a range of diseases, specifically infectious disease, cancer, cardiology, and rare diseases. Tell us about Moderna's mRNA platform.
Stéphane Bancel: We have spent considerable time thinking about, designing, and improving our platform. Simply put, our platform is a series of technologies that collectively allows us to deliver mRNA to patients to treat their disease. The promise of mRNA is very clear. In principle, it allows the translation of a protein whose absence (or insufficient quantity) results in disease. However, our immune systems are able to detect and remove foreign genetic material. Our scientists have discovered a number of technologies to address this challenge and thus harness the therapeutic potential of mRNA. For example, we have developed ways to stabilize the mRNA molecule to avoid detection and degradation, we have developed vehicles to deliver the drug to tissues of interest, and we have optimized manufacturing of mRNA therapeutics at high yields. These technologies and many others make our platform the foundation of everything that we do.
We have also given considerable thought to how we apply our platform across the broad range of diseases that we can reach with mRNA therapeutics. Our strategy is to pursue a range of mRNA modalities in parallel. For example, we are pursuing a number of mRNA vaccines, cancer therapies, and rare diseases, to name a few, at the same time. Our platform allows us to scale rapidly within and across these modalities and others as we validate the use of mRNA therapeutics through clinical studies with our lead assets.
McKinsey: What role do digital technologies play in these efforts?
Stéphane Bancel: We have been a digital company from the very beginning and in everything that we do. Our mission is to bring mRNA therapeutics to patients, and the digital nature of our platform enables us to do this more robustly and efficiently.
Due to the nature of mRNA therapeutics, we realized very early that we could significantly compress the time from when a researcher had an idea for a new mRNA therapeutic to the time when the drug enters the clinic. We did a few things to make this a reality. First, we created a digital drug-design studio that allows our researchers to design a protein, and then identify the mRNA sequence and appropriate vehicle to deliver the mRNA to the tissue of interest. Second, we use advanced analytics to identify the optimal sequence of mRNA—taking into account the impact that slight variations in sequence can have on 3-D structures and transcription rates. Third, we have automated most of the steps in producing a product that is ready to start laboratory testing. Taken together, these steps allow us to go from an idea to getting a drug ready for an investigational new drug application in a matter of months. For example, it took ten months to do discovery with our partner on mRNA MRK-1777.
McKinsey: What has been the impact on Moderna's R&D productivity and timelines?
Stéphane Bancel: The impact has been substantial. We have advanced more than ten assets into the clinic in the past two years and have an exciting pipeline of ten other development candidates following right behind. Our throughput is now running at five or more assets per year into the clinic, a pace that we are very proud of. On the cost side, we have made equally impressive gains. Our incremental cost to bring an additional asset into the clinic is well below the industry average. The speed and cost benefit is one of the reasons that our strategy is to scale rapidly within and across our modalities of interest. So it is the combination of the performance of our platform and our strategy to rapidly scale and discover and develop mRNA therapeutics for a range of diseases that holds enormous potential for patients and for Moderna.
Biotech companies with a biomolecular platform are forging a different path, in which the platform itself is the source of value creation. They start by building the platform and designing a set of experiments to demonstrate the viability of the platform as a therapeutic modality. For instance, they may test whether the platform can be used to deliver vaccines. Then they identify a range of diseases across various therapeutic areas or clusters of related underlying biology that the modality could address, and prioritize drug discovery and development across those diseases (see sidebar, "Interview: How Moderna uses its digital capabilities to power its mRNA platform").
Biomolecular-platform companies therefore typically have a variety of different therapies in development. There is still correlated risk across drugs that are discovered and developed with the same genetic-information-driven platform. But the variety of modalities, and the ability to sequence development of drugs targeting different biological pathways, provides a more balanced risk-adjusted portfolio.
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Companies that take this approach usually adopt a staged development process, which starts by selecting a disease for which the clinical end-point is established and straightforward to test. Once proof of concept has been validated, the platform then allows more-rapid and lower-risk development of therapies for other diseases. The careful selection of initial diseases can mitigate biology risks in certain related clusters of diseases with similar underlying etiology. This de-risking allows companies to stage their investments, then scale them up to address a broad range of therapeutic areas. The approach is being applied across a range of biomolecular platforms, from DNA-based gene therapies to CAR-T therapies to emerging microbiome platforms.
The corollary of the versatility of these biomolecular platforms is the need to make significant investments and to scale up rapidly. This is difficult for three reasons. First, even before the specific disease targets are identified, significant up-front investment is required to establish the platform. Second, companies must take steps to protect their intellectual property and other proprietary investments. Third, running multiple clinical programs at the same time calls for efficient and scalable operational processes and a flexible operating model that allows for rapid resource allocation.
Digital as a source of value creation for biomolecular platforms
The combination of genetic-information-driven technologies and an innovative approach to R&D positions biomolecular-platform companies to transform their research enterprises by taking advantage of digital opportunities. It doesn't hurt that many of them have been formed in the past decade—and so lack the built-in brakes that can slow down bigger firms. These young companies are coming of age as "digital natives."
The road to digital success in pharma
A number of characteristics make digital an integral part of the business model of biomolecular-platform companies. In fact, digital can help all along the value chain.
Drug discovery:
Digital techniques can accelerate the progression from initial concept to drug candidate.
Optimizing drug design through the use of algorithms and advanced analytics may improve the chances of success.
Automation enhances repeatability and speed.
Preclinical:
Digital technologies can be used to automate the production of clinical trial-grade material.
The ability to apply learning and data from other pipeline assets produced by the same platform may reduce the burden of data collection and obviate the need for certain steps in the development process, such as toxicology and preclinical safety.
Clinical development:
Well-designed experiments in one or a small number of diseases can inform and reduce risks across a broad range of diseases. For example, experiments with microbiome-based therapies are being designed to guide entry into a broader range of diseases.
Many diseases have significant unmet needs, such as certain types of cancer or rare diseases, which enable the use of expedited development and regulatory paths and accelerates the approval process for new drugs.
Manufacturing:
Digitization can help to reduce the number of ingredients and process steps.
Optimizing product design and manufacturing may improve downstream yields as well as biological effects, such as sequence optimization for RNA products and transcription levels for DNA gene therapies.
That is the potential. In practice, there are few examples of companies using digital effectively all along the value chain. This may be a lost opportunity. We have found that areas where digital is not applied tend to become bottlenecks, delaying scale-up and depressing value creation. This also may be a factor in the recent burst of M&A activity. Larger companies sense a potential to add value by infusing expertise and capabilities to help accelerate the scale-up and apply their digital capabilities to the platform.
Digital technologies enable the fast, replicable, and systematic application of the underlying biomolecular-platform technology to a broad range of diseases. And the potential is growing, as more and more companies—including traditional biotech and pharmaceutical firms—are beginning to develop biomedical platforms. As the benefits of digital prove themselves, both biotech pioneers and larger pharma companies are increasingly positioning themselves to capture the potential of their biomolecular platforms. In so doing, we expect that this will be a major impetus to help the pharmaceutical industry close the digital gap relative to other industries. In the meantime, biomolecular-platform companies have demonstrated the value that digital can deliver.
Olivier Leclerc is a senior partner in McKinsey's Southern California office, and Jeff Smith is a partner in the Boston office.
The digital imperative for pharma companies in Japan
A digital prescription for pharma companies


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text:
Getting the Gold (Exodus 24; 31-34)
A huge thank you to Mary for this transcript!
Channing: [00:00:00] Hi! I'm Channing.
Elise: And I'm Elise.
Channing: And this is The Faithful Feminists Podcast.
Elise: [00:00:12] We focus on feminist interpretations of scriptures and follow the LDS Come Follow Me manual as a guide for study. We understand scriptures can be a tricky endeavor for readers, but we also believe sacred texts contain compelling examples of loving and liberating relationships with The Divine, others, and ourselves. We hope you'll join us in exploring the problems and promises of sacred texts with imagination, critique, and celebration to reveal what we feel is the loving and liberating heart of scripture.
Channing: [00:00:41] While Mormonism, with its iconic floral foyer couches, is our background, we follow our faith and our God on the winding path of spirituality over institution, and connection over condemnation. We are fellow wanderers, weavers, and doubters. If you've found yourself feeling a little too faithful for some and not enough for others: Welcome. We've saved you a seat on the soft chairs. This podcast is funded by our listeners' generous donations. If you'd like to support our work, connect with us on Patreon or on our website at www.thefaithfulfeminists.com.
Hi friends! Welcome back! Today's episode we'll be discussing Exodus chapter 24 and 31-34 for the dates April 25th through May 1st. We're so super glad you're here. It's been a long time, or at least for us it feels like a long time. We haven't been able to sit down and really dive into the text for a couple of weeks. So we're really excited to be back. Thanks so much for your patience as we've worked on some extracurricular projects and just nourished ourselves and spent some really necessary time together.
So today, like we said, The Come Follow Me manual only assigns chapter 24 and chapters 31-33 as the remaining assignments for Exodus, we wanted to give just a really quick overview of the chapters for the rest of the book, just so that we can all construct a timeline of events from where we were in the last full episode that we recorded and where we'll be going in the future. So in last week's chapters, 18 through 20, which we didn't have an episode for, the manual covered Moses's preparation and receipt of the 10 commandments on Mount Sinai, as well as the creation of shared leadership by appointing spiritual leaders for the Israelites operating underneath Moses. Chapters 21-23 outline the law of Moses with guidelines about Sabbath day practices, sacrifices, the proper treatment of widows and servants and the infamous "eye for an eye, tooth for tooth" way of life. And chapter 24, the Israelites covenant to keep the law of Moses and in chapters 25 through 31, we'd get an outline for how to build a tabernacle with its various elements, as well as the vestiges and sacred practices for Aaron and the priests of the tabernacle. For today, most of our focus will be in chapter 32. There is so much going on in this chapter and it has a couple, well, not a couple, but one very iconic story that we wanted to focus on today.
Elise: [00:03:38] And I think even before we get to Chapter 32. One thing that caught my eye in chapter 31 is actually the section heading that reads "Artisans are inspired in building and furnishing the tabernacle." And this line stood out to me because hopefully as people know you and I really value and cherish arts in all of its forms, especially art as experience. I mean, we just finished this whole entire Holy Week series of poems and creative essays. You and I both draw and paint and we love being in the art museum. And even on our website, we have a line that reads, "but more than that, we believe that artists, creators, activists and beauty makers are essential to imagining a world where all can flourish." And I think this chapter heading reminds me again of the important role that artists and creators play in making the world a better space. And that includes building beautiful worship spaces and also social justice spheres. Like our amazing artist friend, Michelle Franzoni Thorley, who's advocating for more diverse and inclusive representations of divinity in congregations and church buildings. Or another example is artist Camilla Stark, who's creating this super cool graphic novel to fight climate change. So I really love, specifically in chapter 31, but even the chapters that come before it, that aren't covered in the Come Follow Me manual, I like seeing the role that the community plays, but most importantly, the role that the artists play or the crafters make, or the cobblers and the sculptors and the people that are really participating in building a beautiful space for worship. This also reminds me about art and architecture in our churches and worship space. Author Janet Wooten summarizes Rosemary Radford Ruether's description of the possibility of what a purpose built complex or church for worship could be. And they spend a lot of time focusing on the architecture when they say, "the space would need to be both centering and elevating." She describes a circular space with a dome to let in natural light and oriented to catch light at both winter and summer solstices. Under the celebration center, there would be a crypt for rituals connected with birth and death. The whole complex would consist of the celebration center, an egg shaped building for study or conversation, gardens, pools, saunas, a play center, places for weaving, pottery and other crafts, a library and cottages where people could stay. Wooten also dreams of banners and tapestries and sculptures and quilts that could connect a congregation's journey and legacy together. I really love dreaming about beautiful spaces and the role that art plays in my own worship. I remember once when Channing was in Phoenix we went to a Franciscan church and retreat center and the entire grounds really seem to have this artful approach in the way that the buildings worked in complement with the environment and the landscape. It really brought to the forefront, not just that we were on sacred ground, but really that the artful crafting of this ground was a sacred experience.
Channing: [00:06:56] Yeah. I also remember too, when you came to visit me, that we went to the Cathedral of Mary Magdalene in Salt Lake. And I remember just walking in and seeing how vibrant and colorful the entire cathedral and the chapel was and how we could just walk along, yeah, any portion of the building really, and admire the stained glass windows, the paintings, the sculptures, and just take in all of the gorgeous symbolism and stories that were unfolding in this space without anyone really having to speak or present.
And I just, I appreciate those moments of recognizing that there are so many other ways to worship than what we encounter in our own LDS chapels, which can sometimes be aesthetically bland, I think is probably the right way to say that. Which I think is also like, really ironic because the background of our podcast cover art is probably the most colorful thing I've ever seen in the church building anywhere.
Elise: [00:08:08] Yeah. The paisley couch.
Channing: [00:08:08] Yeah, exactly. But I just, I love the idea of creating an envisioning and working together and crafting communities and spiritual practices and spiritual ideas. And there's, so there's so much potential there. And so much, I think even just for you and I, when we've gone to museums or artful spaces, or even just like sat in a park and like sketched buildings and random visitors, that there's a certain kind of connection that is made through beauty and through aesthetic and through art and I just love this connection that you've made here with the text of an illumination of encountering the divine through art. It's just incredible.
Elise: [00:08:56] Yes. Thank you. And I know that my life has been made richer, my worship has been deepened, and my belief in a higher power has been made far greater because of the work of artists and architects and creators who help me commune with God.
And so I'm really grateful that those themes were also highlighted in chapter 31.
Channing: [00:09:16] As we move from this really beautiful imagining and reverence for artful spaces we move into, I don't know, maybe another iteration of art, which is kind of funny, it's a little tongue in cheek way of looking at this. But we move to chapter 32 which tells the story about the golden calf. And the traditional telling of the story, and the one that shows up in the text, is that the Israelites wanted to create a golden calf to worship. And so Aaron said, "okay, everyone gather up all of the gold jewelry and we'll melt it and we'll create this golden calf." Meanwhile, Moses is up on Mount Sinai talking with God and they're having these really deep spiritual conversations, I imagine, until at one point, God says, "Hey, Moses, all of the people down in the valley have created this golden calf and I am pissed." And Moses is like, "Oh, okay. I will go fix it." So Moses goes down to the valley and he approaches Aaron. And he's like, "What is this golden calf?" And Aaron was like, "Well, the people said that they wanted one and they just gave me their earrings. And I melted it. And then out of a fire came this golden calf." And Moses is like, "Okay, highly likely story." And then more drama unfolds from that point, which we'll get to later, but that is the story of the golden calf. So I'm excited to kind of dive into the story.
Elise: [00:10:54] I really like your telling of this story, because it brings it to life in a different way than the text does. And one of the lines that stood out to me is that when the people turn to Aaron, because Moses has been up on the mountain with God for so long, the people turned to Aaron and they say, "Aaron, can you please make us gods that shall go before us? For, as far as Moses goes, the man that brought us out of the land of Egypt, we don't know what's become of him. So like, we don't know what to do now." And in my first reading, in my attempt to be a compassionate reader, I hear the people may be experiencing a bit of fear. Maybe they feel that they've been abandoned by both their God and their prophet leader. I think that they might be feeling a bit of uncertainty and they also might feel disconnected and have a lack of direction. And so I think in the most generous reading, these people are trying to say, "We need help. We're afraid. Can you please point us in some directions so that we can know where to devote our attention?" And maybe even the people are looking for a way to reconnect with God and remind themselves of the God who brought them out of Egypt. So in this way, I don't actually think, even though this golden calf comes out of the, I don't know, pot of gold, I don't think that the people actually have mistaken the golden calf for the God who brought them out of Egypt. But I do think that they were looking for a physical reminder of a supernatural being. I think that they were turning to this golden calf in an attempt to reconnect with God. And at its best, I believe that that is also what rituals and symbols can do for us. Rituals and symbols can point us toward God.
And one of the questions I asked when I was reading was when do I find myself pulled towards symbols and metaphors and rituals in an attempt to connect to God? What do I need in my own life that I'm trying to replace with a golden calf? And yet granted, even with this most compassionate, most generous reading, I also know that in the text the commandment is still really explicit because in Exodus chapter 20 verse four, it says, "thou shalt not make unto thee any graven image or any likeness of anything that is in heaven above or that is in the earth beneath or that is in the water under the earth." So I recognize that this is both a direct commandment and a direct covenant that the people have entered into with God to not have any graven images or idols created to replace God. And because of this, this actually caused Channing and I to do a little bit more research, as opposed to only relying on our first gut interpretation, which led us to something new.
Channing: [00:13:42] Yeah. So we came across an article titled "Hebrew Women in the Wilderness: Midrash and Aggadah" by Tamar Kadari. And in this article, they illustrated that rabbis show women who wandered in the wilderness as righteous, more righteous than the men. Women also resisted the sin of idolatry in the creation of the golden calf. In Exodus 32:2, Aaron says to the people, "Break off the golden earrings, which are in the ears of your wives, of your sons and of your daughters and bring them unto me." In this Kadari says that men were eager to build the calf. So they asked their wives for their jewelry, but the women were unwilling to cooperate in this sinful activity. So, as a consequence, only the men contributed their jewelry. The scriptures say, "And all the people took off the gold rings that were in their ears," but the scriptures do not specify that the women offered their ears. The article makes the argument that this example showcases women's loyalty to God and to the commandment. And also that women were rewarded with the Jewish holiday dedicated to them called Rosh Chodesh, the monthly celebration of the new moon. This includes themes of atonement, renewal, rebirth, and not doing work so that they can gather together and celebrate. And we just want to note here that featuring Rosh Chodesh is not an invitation to conduct your own Rosh Chodesh celebration as it is uniquely Jewish.
Elise: [00:15:16] I'm really glad that we did a little bit more research to find out this midrashic tradition that showcases that another interpretation of this story is that the women actually held true to their covenant, held true to their faith and promised to only ever worship God. And then seeing how this scripture has influenced the Jewish holidays and tradition around Rosh Chodesh is a really lovely way to, one, find the women in the text and, two, see how the text really shapes and can continue to influence our lives.
Channing: [00:15:36] That's really beautiful as we were going through reading this text, I was also reminded of something that I had read in "The Screwtape Letters"- which was written by C.S. Lewis- about idolatry. And I have a really well loved copy sitting on my bookshelf. I really do love this book. It makes me smile. But for anyone who's not familiar with it, "The Screwtape Letters" is a book that's written in letter format, framed as demons who are talking to one another and instructing each other on how to properly tempt humans. And in one of the letters, one of the demons writes to his understudy, "You will find an individual human's conception of God to be a composite object, containing many ridiculous ingredients. There will be images derived from the incarnation. And I have known cases where for some, their God was actually located up and to the left at the corner of the bedroom ceiling or inside their own head or in a crucifix on a wall. But whatever the nature of the composite object, you must keep him praying to it. The thing that he has made, not to that which has made him. Once thoughts and images have been flung aside, or if retained with a full recognition of their subjective nature and recognized as never fully knowable by them as they are known by it, that is when the incalculable may occur." And I really love this quote. And I always think about it whenever I think about or hear about idolatry, because it reminds me of a phrase that Elise and I often say on the podcast, like literally, Elise, I bet you know what it is. It's that God is always more than we expect God to be. And I think Lewis does a really good job of illustrating that when we worship an image of God, It might be worth asking ourselves, could this image possibly be what Lewis calls, a composite object, containing many ridiculous ingredients? We can ask ourselves: where do these ingredients that we believe make up God come from? Maybe individually they'd look nice, but in concert with other ingredients, they can become harmful. In one case maybe God is a composite of men's gold earrings, or maybe our particular composite is made up of cherry picked pieces from various hierarchical systems. But when we are willing to fling aside our images of God, or like C.S. Lewis alludes, recognize that the images of God we have created are subjective, we can be surprised by what happens after; C.S. Lewis calls it the incalculable.
Elise: [00:18:52] Another part of the golden calf story that was interesting to me is the way that God responds. When God realizes that the people are starting to worship this golden calf, God says to Moses, "Now, therefore, let me alone that my wrath may wax hot against them and that I may consume them." And here we can see, God is super pissed. God actually says, like, "Leave me alone. I'm so mad that I'm going to lose it and I'm going to consume and like, kill all of these people." But Moses says in response to God's anger, "Why are you getting upset at the people that you brought out of Egypt? Don't go ahead and kill all these people because then the Egyptians are going to say, wow, God just freed the Hebrews only to turn around and then slay them in the mountain." Moses says, "Turn from my fierce wrath and repent of this evil against my people. Remember the covenants that you have made with these people, remember Abraham and Isaac and Israel. Remember the covenants you have made to multiply and protect your own people." And then verse 14 says, "and the Lord repented of the evil, which he had thought to do unto this people." And this for me is really remarkable to see Moses pushing back, critiquing and calling out God. First, because it levels the power dynamics and puts God and Moses on common ground. It also showcases Moses's trust in the relationship that he has with God. Moses knows because of the trust that he has in the relationship with God, Moses knows that this relationship can sustain a call-out and a critique. And I feel really blessed to have friends that can do that for me, but I feel most especially blessed to have you, Channing, as a friend who is willing to call me out, who's willing to hold me accountable, who's willing to remind me of who I am at my core when things get a little fiery for me or when I'm not acting as my highest, best, most-healed self. And I think even in those moments of conflict or when we have to push back on each other, our relationship has been made deeper through the critiques and call-outs, and that's also thanks to the trust that we have in one another.
Channing: [00:21:04] Yeah, I've always really appreciated that about our friendship, because I think it really offers us a unique gift in knowing that we can trust each other to say how we're really feeling and what we're really seeing pop up in these experiences with each other. So I don't have to leave a conversation with you wondering like, "Oh my gosh, did I say something wrong? Did I do something wrong? I can't believe that I said XYZ," or whatever because you and I have built the trust into the relationship that we don't have to wait until the conversation is over and then return to it. We just say it in real time. And it's always very gentle and rooted in relationship and compassion and a shared desire to be our best selves with each other. And I've always really treasured that because then, in this particular case, and in these particular circumstances, call-outs always feel like a gift because it shows me where I can deepen my love for myself, for other people, and for the divine.
So I'm always so grateful for our ability and willingness to do that for one another.
Elise: [00:22:22] Yeah, me too, that is really such a gift because friendships and relationships have the possibilities to help make us better people. And I think that's one thing that we can see here between Moses and God: Moses trusts God, and God trusts Moses.
And so when Moses says, "Hey, I'm not going to let you let your wrath wax hot against the group of people and then consume them. And by not letting you freak out on them, I'm doing this because I love you." And then I can also imagine God when they've chilled out a little bit, I can imagine that God is really grateful for Moses, for reminding them of their true character, a God who is loving through and through who is patient and long suffering. And I think that's a real gift and an encouraging exchange that we see between Moses and God that Moses can critique and call out and hold God accountable. And then God actually turns around and repents, wants to do better, has a change of heart. Here too, if God themselves can pause and repent, it's a huge reminder for me to do the same thing. And it shows me that it's not necessarily my anger that I need to repent of, but it's the acts that follow or that could follow and get me into violent places that need to be repented of. It shows me that I need people who love me and see me and can remind me of who I am when I've really lost my way. I need friends who can call me out and hold me accountable. And the friendships that do that for me are the ones that are built on trust.
Channing: [00:23:56] I love this section of this chapter and I wish knowing what comes afterward, that the chapter just ended here and we could just celebrate it with all of its amazingness, but we've been in the scriptures for like two and a half years now. And that's just never the way this ever shakes out. So, unfortunately there's still more that happens in this chapter and it gets quite violent. After Moses and God have this really incredible interaction about compassion and repentance, Moses returns from Mount Sinai to the Israelites and basically says, "I'm on God's side, who else is on God's side?" And all of the Levites, it's all the Levite men stand up and God says, "Okay, thank you, Levite men. Now you can go kill three men each, of those people who participated in creating this idol." And so collectively these men go out and kill about 3,000 of the Israelite men and then afterwards, Moses returns to Mount Sinai and says to God, "I took care of it. I really took to heart how upset you were. And so I want to just say, like, if you need to blot my name out of the book of life, you can do that." And God's like, "I'm not gonna do that." And then the chapter ends, so that is what we have to work with at the end of chapter 32. And needless to say, we have mixed feelings about Moses.
Elise: [00:25:38] Yeah, like, because part of me thinks, "Wow, Moses, you, you just did it. You just stopped God from consuming all of the people, but the minute you come down from Mount Sinai, your next command to the people is to go murder 3,000 of them?" I don't, it's just not making sense for me. And I wished that Miriam or Aaron, or one of Moses's gazillion friends or followers had called Moses to repentance, had reminded Moses of who he was at the core in the same way that Moses did for God. And this is me also assuming that no one did that, maybe lots of people did and Moses didn't listen. And yet later in the story, it's Moses who's intervening between the people and God in an attempt to atone for the sins of the people. Just like Channing said, Moses shows up to God after the killings have finished. And Moses says, "Okay, it's covered. All of the sins of the people can be put upon me and you can kind of like write me off." And God doesn't. So it's confusing because Moses goes to bat for his people, but he also commands them to kill each other. And I don't know how to make sense of this right now. What seems to right now, what I'm sitting with is just the reminder that, not just that people are complex, but also that my lack of exposure to and study of the Hebrew Bible confronts me with new challenges that are unlike the challenges we've grappled with in the Book of Mormon or in the Doctrine and Covenants. In our experience, even in the first four months of this year for the podcast, we see wilder, more magical stories. We see bigger gods who are mad, but they're complex and growing. And of course we see prophets like Moses who are really messy. So I don't have perfect sense made of this, but all of this is just to say that the Hebrew Bible is challenging and I feel really lucky to be able to read and learn this year. And kind of practice holding both the amazing parts that feed me and the really challenging parts that make me concerned and question a lot of things that I think I know about God or prophets or liberation.
Channing: [00:27:55] Yeah. Yeah. And that's something that you and I definitely have grappled with off-air is just the intensity of the Hebrew Bible. And I think that that really speaks to, I don't know, its ability to kind of hold this timeless story of people's experiences with each other and people's experiences with the divine. The Hebrew Bible is an old text and so it has mythical proportions to it. And I think that it's a lot to ask any reader of the text to encounter and then walk away from tricky portions, just like this one, with any type of surety or certainty about the meaning of this story or what to do with this story.
And so I really appreciated your perspective here in saying, like, "Wow, I was really confronted with my own experience of this chapter and not being provided with a clear answer." And that's something that we've always been very grateful for and very frustrated by as we've moved through the text- all of them so far. And I'm sure that this won't be the last time for either one of us.
Elise: [00:29:13] Yeah. Yeah, that's right.
Channing: [00:29:13] Before we finish out the episode for today. I just wanted to spend a little bit of time in the chapters that remain outside of the Come Follow Me assignment. What really stuck out to me in these chapters that mostly focus on the creation of the tabernacle, the artists involved in the creation of the tabernacle. So that really sums up chapter 32. And from here we have a handful more chapters before the book of Exodus is complete. Chapters 33 and 34 documents a handful of further interactions between Moses and God. Some of them happen face-to-face and others occur through what the texts calls, "cloudy pillars" and also happened on Mount Sinai in which God and Moses make and receive more commandments and covenants. Chapters 36 through 40 outline the creation of the tabernacle, the arc, the mercy seat, altars, incense, anointing oils, the breastplate of Aaron, and other priestly garments. The men of Israel make sacrifices in the tabernacle and Moses blesses Israel. And these chapters finish out the book of Exodus. And before we wrap up the episode for today, I just wanted to share some thoughts that I had about some of these remaining chapters that were left out of the manual reading assignment, because I really think that they speak to something that, Elise, you alluded to earlier, which was the importance of ritual. I'm sure that we've spoken before about our shared fascination with ritual on the podcast, because it's something that Elise and I are just totally intrigued by. It literally, we're just fascinated by it, but I think we'll continue to see ritual be really important throughout the Hebrew Bible, because there's something really compelling, like, just so interesting about the embodied act of ritual. Ten chapters from the book of Exodus focus on exact preparation for worship. And a question that I had about this is: what can this teach us about the relevance of ritual? We've said elsewhere that ritual is an act of reverent embodiment. Ritual returns us to the body through the senses. Something about the exactness of the instructions for ritual preparation and performance is something that really challenges me in the text. I think there's something really rich in extravagantly precise ritual. In some ways these rituals take us out of ourselves by honing our focus and offering clarity and intention. I also think that if all worship always must be an extravagantly precise ritual, it becomes a distraction. And this is one place that I actually think the LDS church maybe gets ritual right. Extravagant rituals are performed almost exclusively in the temple, but a less involved yet still precise ritual is in the sacrament. The more capacity for presence and engagement, the more elaborate the ritual, just like we find in the temple. However, the more potential for distraction or disruption, the less elaborate the ritual like teenage boys passing the sacrament to a chorus of screaming toddlers and crying babies. And yet both are effective in providing opportunity for reverent, present embodiment. The text really seems to revere and honor rituals founded on extravagant exactness. And so questions that I want to ask about this week's texts are: How might ritual enhance or facilitate my connection with the sacred in new and unexpected ways? What rituals are already a part of my spiritual practice? What do I enjoy about them? What do I wish there was more of? And finally, how can I better nurture my own reverent embodiment?
Elise: [00:33:25] Thank you so much for being with us this week. We're really glad to be back into the normal Come Follow Me flow of the podcast. And we also want to issue a special thanks to our transcription volunteer team who have been so lovely in preparing all the transcriptions for our website. Thank you. Thank you. Thank you.
Friends, thank you so much for joining us today for another episode of the Faithful Feminist Podcast. We know your time and space is sacred and we are so grateful to have spent ours with you. If you enjoyed this episode, we'd be so happy if you left us a loving rating on iTunes and Spotify. So other seekers can find us.
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Pankaj Udhas Songs & gazal lyrics.
Pankaj udhas Songs & gazal downloads.
Where to listen Pankaj udhas online.
Pankaj Udhas is a pre-eminent Ghazal singer from India. He is credited with bringing this unique singing style where Urdu verses of poets are set to music to the mass audience across the country along with other musicians like Jagjit Singh and Talat Aziz.
Pankaj Udhas was born on 17 May 1951 in Savarkundla in the Gujarat State in India. His older brother Manhar Udhas achieved some success as a Hindi playback singer in Bollywood movies.He had studied in Sir BPTI Bhavanagar. His family moved to Bombay and Pankaj attended St. Xavier's College in Bombay, Pankaj was first noticed as a professional singer in the film Naam (1986 film), in which his song Chitthi Aayee Hai became an instant hit. He recorded several albums since then and toured the world as an accomplished Ghazal singer. He has also composed music for many films and performed as a playback singer for others.
He received the Padma Shri, a Government of India civilian award in 2006.


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Soviet artists Tkachev Brothers
Soviet artists Tkachev Brothers. During the years of collectivization. Oil. 1980
Talented Soviet artists Tkachev Brothers – Alexei and Sergei were born in the village of Chuchunovka of Bryansk region; Sergey in 1922, Alexei in 1925. People's Artists of the USSR Alexei and Sergei Tkachev – has been working as a unique tandem since 1952. Natives of a large peasant family had to fight for their dream – to go through war and poverty. However, the ordeal only tempered character, and the theme of heroism of a common man has become central in the work of the brothers. Alongside with heroism, the theme of Russian village in the focus of the artists. Heroes of their paintings – real people, contemporaries, family, friends, neighbors in the village where they grew up. At the same time, the artists seek to create typical images, which embody the national character. Through the prism of rural life, exacerbating the effects and characteristics of the characters, Tkachev convey the "truth of time," the drama of their country. Brothers Tkachev said: "Without the Soviet power we would become shepherds". Their paintings are stored in many museums, including – the State Tretyakov Gallery, the Russian Museum and more than a hundred museums in Russia and the CIS countries, the US museums, Italy, China, as well as in private collections in twelve foreign countries.
Aleksei Tkachev
Soviet artists Tkachev Brothers. Between the fights
Aleksei Petrovich Tkachev was born September 11, 1925 in the village of Chuchunovka of Bryansk region. In 1939, he entered the newly founded Moscow Art School. 1941 – 1942 worked in evacuation at the plant "Uralmash" in Sverdlovsk. In 1951 he graduated from the Faculty of Painting of the Moscow State Art Institute of Surikov (workshop of GG Ryazhsky). Aleksei Tkachev is a full member of the USSR Academy of Arts, Honored Artist of the RSFSR, People's Artist of the USSR, Artistic director of the creative workshop of the Academy of Arts, Laureate of the State Prize of the USSR and the USSR State Prize of Ilya Repin.
A. and S. Tkachev. Illustration to the poem by S. Shchipachev 'Pavlik Morozov'. Charcoal. 1952
Aleksei Tkachev was awarded order of "Friendship of Peoples", "Labor Red Banner" and "Badge of Honor", "For Merit" of 3 and 4 degree. Winner of the International Sholokhov Prize – 2005, Russian Government Prize – 2006 and Tyutchev Award – 2007. Winner of the Prize of the Union State in the field of literature and art for 2009 – 2010. Winner of the Prize of the Central Federal District of the Russian Federation in the field of literature and art for 2010. He was awarded the gold medals of the USSR Academy of Arts, the Gold Medal of Surikov "For outstanding contribution to Russian art."
Alexander Tkachev, Sergei Tkachev. Light. Oil on canvas. 1970 – 1972
Sergey Tkachev
Sergey Petrovich Tkachev was born November 10, 1922 in the village of Chuchunovka Bryansk region. In 1938 -1941 he studied at the Vitebsk Art School. Member of the Great Patriotic War, was seriously wounded. In 1952 he graduated from the Faculty of Painting of the Moscow State Art Institute of Surikov (workshop of SV Gerasimov, DK Mochalsky). In 1976 – 1987 was elected chairman of the Union of Artists. 1980 – 1985 – The deputy of the Supreme Soviet of the USSR. Full member of the USSR Academy of Arts, People's Artist of the USSR, Honored Artist of the RSFSR, Laureate of the State Prize of the USSR and the USSR State Prize of Ilya Repin.
At lake
He was awarded the Order of the Patriotic War of II degree, "Friendship of Peoples", "Labor Red Banner", "Badge of Honor", "For Merit" grade 3 and 4, the medal "For Courage", "For Military Merit", "For Victory over Germany." Winner of the International Sholokhov Prize – 2005, Russian Government Prize – 2006 and Tyutchev Award – 2007. Winner of the Prize of the Union State in the field of literature and art for 2009 – 2010. Winner of the Prize of the Central Federal District of the Russian Federation in the field of literature and art for 2010. He was awarded the gold medals of the USSR Academy of Arts, the Gold Medal of Surikov "For outstanding contribution to Russian art."
Soviet artists Tkachev Brothers. Young family. 1983-1984
In 1995, at the home of painters in Bryansk was opened Tkachev Brothers Museum, to which they donated more than 500 of their paintings.
At the well. 1960
Children of war, 1984
Daughters. 1976-1977
In the years of collective farm. 1972
June afternoon. 1983-1985
lilac bush
May of 1945. 1980
Memories of mother. 1998
Mothers. 1960-1961
Old woman. 1961
Old women. 1960
Olga at the fence. 1975
Portrait of veteran of Great Patriotic War S. Tkachev
Russian field. 1990-1995
Soviet artists Alexei and Sergei Tkachev 1960
Soviet artists Alexei and Sergei Tkachev 1981-1983
Spring rain
Washing linen. 1957
Wedding in the village. 1988-1989
A. and S. Tkachev. Children of Peace. Oil. 1982-1985
A. Tkachev. Pavlik Morozov. Oil. 1944
A. Tkachev. Self-portrait. Oil. 1943
On the native land. 1977-1980. Oil, canvas. Soviet artists Tkachev Brothers
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