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Professur für Gesellschaftsanalyse und Sozialen Wandel
SoziologieGesellschaftsanalyse und Sozialer Wandel
Wintersemester 2017-2018
"Zukünfte der Nachhaltigkeit"
Gastwissenschaftler/innen
Prof. Dr. Sighard Neckel
Moritz Boddenberg, M.A.
Martina Hasenfratz, M.A.
Marco Hohmann, M.A.
Sarah Pritz, Mag. Bakk. phil.
Timo Wiegand, Dipl. Soz.
Manuela Pires
Christian Eberlein, B.A.
Timo Wiegand, Dipl.-Soz.
Foto: S. Neckel
Sie sind hier:UHH > WiSo-Fakultät > Fachbereich Sozialwissenschaften > Professuren > Sighard Neckel > Forschung > Gastwissenschaftler/innen > Prof. Juliet Schor
Prof. Juliet Schor
Foto: Boston College/Burke
Gastwissenschaftlerin (Mai 2018 - Juni 2018)
Massachusetts 02467, USA
VMP9
Raum: Universität Hamburg: VMP 9/ 314A
E-Mail: juliet.schor"AT"bc.edu
Sekretariat Prof. Dr. Sighard Neckel
Allende-Platz 1
Raum: 342
Fax: +49 40 42838-2418
E-Mail: manuela.castro.pires"AT"uni-hamburg.de
Juliet Schor is Professor of Sociology at Boston College. Schor is also a member of the MacArthur Foundation Connected Learning Research Network. Schor's research focuses on consumption, time use, and environmental sustainability. Schor is currently researching the "sharing economy," via a series of case studies of sharing platforms and their participants. She is also studying the relation between working hours, inequality and carbon emissions. A graduate of Wesleyan University, Schor received her Ph.D. in economics at the University of Massachusetts. Before joining Boston College, she taught at Harvard University for 17 years, in the Department of Economics and the Committee on Degrees in Women's Studies.
Schor's most recent books are Sustainable Lifestyles and the Quest for Plenitude: Case Studies of the New Economy (Yale University Press, 2014) which she co-edited with Craig Thompson, and True Wealth: How and Why Millions of Americans are Creating a Time-Rich, Ecologically Light, Small-Scale, High-Satisfaction Economy (2011 by The Penguin Press, previously published as Plenitude.) Schor's previous books include the national best-seller The Overworked American: The Unexpected Decline of Leisure (Basic Books, 1992) and The Overspent American: Why We Want What We Don't Need (Basic Books, 1998). The Overworked American appeared on the best-seller lists of The New York Times, Publisher's Weekly, The Chicago Tribune, The Village Voice The Boston Globe as well as the annual best books list for The New York Times, Business Week and other publications. The book is widely credited for influencing the national debate on work and family. The Overspent American was also made into a video of the same name, by the Media Education Foundation (September 2003).
Schor also wrote Born to Buy: The Commercialized Child and the New Consumer Culture (Scribner 2004). She is the author of Do Americans Shop Too Much? (Beacon Press 2000), co-editor of Consumer Society: A Reader (The New Press 2000) and co-editor of Sustainable Planet: Solutions for the Twenty-first Century (Beacon Press 2002). She has also co-edited a number of academic collections. Schor's scholarly articles have appeared in the Economic Journal, The Review of Economics and Statistics, World Development, Industrial Relations, The Journal of Economic Psychology, Ecological Economics, Social Problems, The Journal of Industrial Ecology, The Journal of Consumer Research, The Annals of the American Academy of Political and Social Sciences, and The Journal of Consumer Culture, among others.
Schor is a former Guggenheim Fellow and was the Matina S. Horner Distinguished Visiting Professor at the Radcliffe Institute at Harvard University in 2014-15. In 2014 Schor received the American Sociological Association's award for Public Understanding of Sociology. She is the recipient of the 2011 Herman Daly Award from the US Society for Ecological Economics. In 2006 she received the Leontief Prize from the Global Development and Economics Institute at Tufts University for expanding the frontiers of economic thought. She has also received the George Orwell Award for Distinguished Contributions to Honesty and Clarity in Public Language from the National Council of Teachers of English. She has served as a consultant to the United Nations, at the World Institute for Development Economics Research, and to the United Nations Development Program. She is also a former Brookings Institution fellow. In 2012 Schor organized the first Summer Institute in New Economics, a week-long program for PhD students in the social sciences, and repeated the program in 2013.
Schor is a co-founder of the Center for a New American Dream (newdream.org), a national sustainability organization where she served on the board for more than 15 years. She is the Chair of the board of the Better Future Project, one of the country's most successful climate activism organizations. She is a co-founder of the South End Press and the Center for Popular Economics. She has also served as a Trustee of Wesleyan University, and as an occasional faculty member at Schumacher College. Schor has lectured widely throughout the United States, Europe and Japan to a variety of civic, business, labor and academic groups. She appears frequently on national and international media, and profiles on her and her work have appeared in scores of magazines and newspapers, including The New York Times, Wall Street Journal, Newsweek, and People magazine. She has appeared on 60 Minutes, the Today Show, Good Morning America, The Early Show on CBS, numerous stories on network news, as well as many other television and radio news programs.
Prof. Katherine Gibson
Prof. Prasannan Parthasarathi
Dr. Barbara Muraca, Assistant Professor
PD. Dr. phil. Katharina Manderscheid
Prof. Dr. Susan Paulson
Univ. Doz. Dr. Beate Littig


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AEC Forensics
Dissecting the Built Environment with Brian L. Hill
Follow @AECforensics on Twitter
About Brian L. Hill
A New Chapter: Xpera Group joins The VERTEX Companies
Brian L. Hill	Link	 August 17, 2020 September 25, 2020 2 Minutes
The press release is below:
Xpera Group's team is recognized as the West Coast's most comprehensive team of construction expert witnesses, construction consultants, and strategic advisors for the built environment.
For Xpera Group, Vertex provides the right fit, as it is an employee-owned company that offers the expanded resources of a multi-disciplinary firm throughout its 25+ office locations.
"The cultural fit, energy and compatibility of our two companies coming together will certainly enhance our ability to serve our clients, expand our services, provide greater growth potential for our people and tap resources well beyond what would otherwise have been possible," said Ted Bumgardner, founder and chairman of Xpera Group. "By joining forces with Vertex, we see an exciting future ahead, as the whole is truly greater than the sum of its parts."
For Vertex, this acquisition augments its west coast presence and expands its services in construction, forensics, and quality assurance. "We could not be more excited about the acquisition of Xpera Group," said Bill McConnell, CEO of Vertex. "Since my first meeting with Xpera's executive team in San Diego, it was abundantly clear that our corporate cultures are in alignment, and Xpera's various practices will complement and expand Vertex's core services, particularly on the west coast. Our mutual dedication to our clients, our teammates, and our ever-commitment to deliver first-class professional services will allow us to continue our growth journey into the future."
Xpera Group will join Vertex's expanding team of consultants across North America and Europe and its clients will now have access to Vertex's suite of specialized services.
"Under the Vertex umbrella, our team will continue to bring the value our clients have come to rely on, while allowing us to expand the breadth of our services to meet additional client needs," said Steve Grimes, president of Xpera Group. "We look forward to the many opportunities this partnership with Vertex will bring to our employees, our clients and the AEC industry at large." Mark Degenaars, a managing director at Vertex, notes, "we are very excited to have the talented team at Xpera join Vertex. Prior to the acquisition, we had the opportunity to collaborate with them on several forensic and construction matters. It was clear we were a perfect fit. Bottom line, Xpera's team is highly skilled and their services add value to our clients."
Vertex is a fast-growth, value-driven, employee-owned AEC firm, who, since incorporation in 1995, has maintained an annual growth rate of over 20 percent. Vertex is routinely ranked on ENR as a top construction, environmental, and engineering design firm. Also, for the past five years, industry benchmarks based on employee surveys have ranked Vertex one of the best firms to work for.
PR Web
Learn more at VERTEX's website
Learn more about Xpera Group
Xpera Group + VERTEX
Xpera Group
Published by Brian L. Hill
As Director of Consulting Services for Xpera Group, Brian L. Hill connects clients to the diverse range of experts, technical specialists, tools and other resources that the firm has to offer in order to solve complex building performance issues. He is also the editor and publisher of AECforensics.com, which dissects the latest news and information impacting quality and risk management in the built environment.	View all posts by Brian L. Hill
Published August 17, 2020 September 25, 2020
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redpajama_set_name: RedPajamaCommonCrawl


It's here! Finally it has arrived!
'Brisneyland by Night' is happily nestled between Jay Lake's 'Mother's Urban Booke of Dayes' and Neil Gaiman's 'The Thing About Cassandra'.
Thanks, Paula Guran and Sean Wallace!
Lisa Hannett has a new feature over on her blog, Tuesday Therapy.
This week, elephants are eaten here.
We went away this weekend just passed, for a combination early anniversary, late PhD, and SO's birthday celebration. We went here and it was pure bliss.
FableCroft! Books! Sale! Christmas Presents!
November 22, 2011	| News, On Publishing, Pimping/Promoting!	| Comments Off on FableCroft! Books! Sale! Christmas Presents!
FableCroft is moving interstate and they are having a HUGE sale. You're looking for Christmas presents, right? You can't go wrong with a FableCroft book!
Or I will add more '!!!'!
The lovely limited edition Hall of Lost Footsteps from Sara Douglass, with intro by Karen Brooks.
… whilst reading a HR document and finding that selection criteria includes "clear annunciation".
I was unaware of the opportunities in the public service to tell virgins that The Lord was going to be their baby-daddy.
Sweet mother of crap, learn to spell … and enunciate.


Dirk Bogarde gives an intense performance as a young man who refuses to allow a family dream to die, in this powerful adaptation of Hammond Innes' best-selling novel.
Scripted by BAFTA winner Robin Estridge and featuring an outstanding supporting cast – including Zulu legend Stanley Baker – Campbell's Kingdom is a moving story of courage, boasting one of cinema's most thrilling and spectacular climaxes. This classic film is featured in a High Definition transfer made from the original film elements, in its as-exhibited theatrical aspect ratio.
Original theatrical trailer and textless material.


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[![Build Status](https://semaphoreci.com/api/v1/pdvend/eventos/branches/master/shields_badge.svg)](https://semaphoreci.com/pdvend/eventos)

Esse é o repositório oficial de páginas de evento da [PDVend](https://www.pdvend.com.br/)!

### Contribuindo
- Faça um fork e clone este repositório
- Crie uma nova branch, nomeando-a com o propósito da sua modificação usando o prefixo `feature/` se for uma evolução ou `hotfix/` se for uma correção.
- Quando terminar de codificar, envie-nos um [Pull Request](https://github.com/pdvend/eventos/pulls)

> Lembre-se de ficar atento aos padrões de arquitetura utilizados no projeto.

### Agradecimentos
- [Create React App](https://github.com/facebookincubator/create-react-app)
- [S(GH)PA](https://www.smashingmagazine.com/2016/08/sghpa-single-page-app-hack-github-pages/)

redpajama_set_name: RedPajamaGithub


Keywords: Zirconium-base glass alloy,	bulk metallic glass,	corrosion.
A Zr-base bulk glassy alloy with a nominal composition of Zr52.5Cu17.9Ni14.6Al10Ti5 (at. percents) was evaluated by conducting corrosion experiments in 0.5 kmol·m−3 H2SO4 and 0.5 kmol·m−3 NaCl electrolyte respectively using electrochemical measurements. Potentiodynamic polarization experiments were carried out with a scan rate of 20 mV/min. Passive current density and pitting corrosion potential were evaluated from potentiodynamic polarization curves. The results indicate that the full glass has a higher resistance to general corrosion and good resistance to pitting corrosion than the counterparts of the partially and completely crystallized glassy alloy. The resistance to general corrosion decreases with increase of the volume fraction of nanocrystalline phases. This is mainly due to the inhomogeneity of microstructure, the structural defects such as grain boundaries, as well as the formation of crystalline phases that have lower corrosion resistance in the partially and completely crystallized samples.


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Submissions to European Journal of Innovation Management are made using ScholarOne Manuscripts, the online submission and peer review system. Registration and access is available at http://mc.manuscriptcentral.com/ejim. For information and guidance on using ScholarOne Manuscripts, go to the ScholarOne help pages: http://mchelp.manuscriptcentral.com/gethelpnow/.
Each paper is reviewed by the editor or co-editor and, if it is judged suitable for this publication, it is then sent to two referees for double blind peer review.
The EJIM aims to provide authors with rigorous and fast review. For papers received between October 1, 2015 and October 1, 2016 the average time from submission to first decision was 83 days.
The author must ensure that the manuscript is complete, grammatically correct and without spelling or typographical errors. Before submitting, authors should check their submission completeness using the available Article Submission Checklist.
Following acceptance of your article it will pass directly into the production process upon completion of the copyright transfer agreement. Having passed through editorial checks and typesetting, proofs will be provided to the corresponding author for checking. Once page proofs are finalised the fully typeset and proofed version of record will be published online. The full process should take no more than 32 business days. The first version to be published will be the "EarlyCite" version, it will not yet be assigned to a volume or issue, but it will be fully citable by a DOI. The EarlyCite version will be compiled into an issue according to the journal's issue schedule, with papers being added by chronological date of acceptance.
Article Length Articles should be between 10000 and 11000 words in length. This includes all text including references and appendices. Please allow 280 words for each figure or table.
Who do I contact if I want to find out which volume and issue my accepted paper will publish in? Following acceptance of your article the fully typeset and proofed version of record will be published online within 32 business days, provided that copyright transfer and proofs are returned to deadline. This will be the "EarlyCite" version, it will not yet be assigned to a volume or issue, but it will be fully citable by a DOI. The EarlyCite version will be compiled into an issue according to the journal's issue schedule, with papers being added by chronological date of acceptance. If required, please contact the Editor for an indication of which issue your accepted paper is most likely to publish in.


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Another reference unit for Paks II. started its commercial operation - Paks 2 EN
Another reference unit for Paks II. started its commercial operation
On 22 March, Unit 2 of Leningrad Nuclear Power Plant II was put into commercial operation.
Another VVER-1200 unit was put into commercial operation in Sosnovy Bor near St. Petersburg, Russia. The commissioning of Unit 2 of Leningrad Nuclear Power Plant II. started in 2020 and ended on March 10 this year with the last 15-day test period. This is the second Russian unit to be the direct reference for the new Paks units, which has started its commercial operation, and the fourth in the line of operating VVER-1200 units. Unit 2 of Leningrad II. has so far generated about 2 billion kWh of electricity.
The VVER-1200 unit developed by Rosatom is a 3+ generation, ie an improved 3rd generation unit type. In its development, safety enhancement was given a prominent role. Rosatom largely took into account the nuclear safety regulations of the International Atomic Energy Agency and the lessons learned from the malfunctions and accidents in nuclear energy.
The first VVER-1200 unit was launched in 2017 in Sosnovy Bor and has been in commercial operation since 2018. In addition to Hungary, such units are being constructed worldwide from Finland through Turkey to China.


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Welcome to Einstein Online - relativity and more! — Einstein Online
Practical Physics This website is for teachers of physics in schools and colleges. It is a collection of experiments that demonstrate a wide range of physical concepts and processes. Some of the experiments can be used as starting-points for investigations or for enhancement activities. Many have links to carefully selected further reading and all include information and guidance for technicians. Physics is a practical science. Practical activities are not just motivational and fun: they can also sharpen students' powers of observation, stimulate questions, and help develop new understanding and vocabulary. Good quality, appropriate physics experiments and investigations are the key to enhanced learning, and clarification and consolidation of theory. We have published a new set of resources to support the teaching of practical science for Key Stages 3-5.
Science&Tech Principle of relativity In physics, the principle of relativity is the requirement that the equations describing the laws of physics have the same form in all admissible frames of reference. For example, in the framework of special relativity the Maxwell equations have the same form in all inertial frames of reference. In the framework of general relativity the Maxwell equations or the Einstein field equations have the same form in arbitrary frames of reference. Several principles of relativity have been successfully applied throughout science, whether implicitly (as in Newtonian mechanics) or explicitly (as in Albert Einstein's special relativity and general relativity). History of relativity[edit] Basic relativity principles[edit] Certain principles of relativity have been widely assumed in most scientific disciplines. Any principle of relativity prescribes a symmetry in natural law: that is, the laws must look the same to one observer as they do to another. Special principle of relativity[edit] See also[edit]
Journal of Cosmology "Invitation" to publish does not guarantee acceptance. All articles are peer reviewed. Approximately 30% of invited articles have been rejected. Approximately 50% of invited articles have been rejected then revised and then resubmitted following peer review, and then accepted. Approximately 20% of invited articles have been accepted without suggested revisions following peer review. Approximately 80% of all articles submitted without invitation, have been rejected. Peer Review The Journal of Cosmology welcomes great ideas. Authors should submit the names, affiliations, and email addresses of 5 scientists qualified to review their paper. All papers are reviewed anonymously by at least two referees who are experts in the field in question. If reviewers suggest publication pending revision, authors will be invited to revise and resubmit the manuscript and to address and respond to criticisms and suggestions by the referees. Papers rejected by both referees cannot be revised and resubmitted. 1).
High School Physics and AP Physics Online Science Daily: News & Articles in Science, Health, Environment & Technology Theory of relativity The theory of relativity, or simply relativity in physics, usually encompasses two theories by Albert Einstein: special relativity and general relativity.[1] Concepts introduced by the theories of relativity include: Measurements of various quantities are relative to the velocities of observers. In particular, space contracts and time dilates.Spacetime: space and time should be considered together and in relation to each other.The speed of light is nonetheless invariant, the same for all observers. The term "theory of relativity" was based on the expression "relative theory" (German: Relativtheorie) used in 1906 by Max Planck, who emphasized how the theory uses the principle of relativity. In the discussion section of the same paper Alfred Bucherer used for the first time the expression "theory of relativity" (German: Relativitätstheorie).[2][3] Scope[edit] The theory of relativity transformed theoretical physics and astronomy during the 20th century. Two-theory view[edit] History[edit]
Wilkinson Microwave Anisotropy Probe (WMAP) Physics and Astronomy Online Portal What is Relativity? Albert Einstein was famous for many things, but his greatest brainchild is the theory of relativity. It forever changed our understanding of space and time. What is relativity? Succinctly put, it is the notion that the laws of physics are the same everywhere. We here on Earth obey the same laws of light and gravity as someone in a far off corner of the universe. The universality of physics means that history is provincial. It's all relative. Special relativity Einstein's theory is divided into special and general relativity. Special relativity came first and is based on the speed of light being constant for everyone. Einstein came to this conclusion in 1905 after experimental evidence showed that the speed of light didn't change as the Earth swung around the Sun. This result was surprising to physicists because the speed of most other things does depend on what direction the observer is moving. Perhaps even weirder, time passes slower the faster one goes. Mass, too, depends on speed.


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The STAR teams OOXYGEN and Gamma-Volantis started the launch campaign for BEXUS 28/29 on October 18th, 2019. 12 of the 15 team members arrived in Kiruna (Sweden) by plane from Dresden and were picked up by bus along with other European teams. After a 45-minute drive we arrived at the Esrange Space Center, in which the Rocket and Balloon launch areas are located and is operated by the Swedish Space Cooperation (SSC). We were in the middle of nowhere, far away from any civilization. Everything was covered in snow and the huge antennas and the Skylark-Tower (which was named after a British sounding rocket, which was launched here several years ago) seemed a bit strange in this beautiful landscape. The buildings, the antennas and the whole area reminded us a bit of a hiding spot for one of the James Bond villains.
Pic 1: Skylark. (May 1th, 2015i. source:https://www.daviddarling.info/encyclopedia/S/Skylark.html [November 5th, 2019]
During the security briefing at Esrange we learned, that it is absolutely prohibited to take pictures on Esrange, except at the dome, which became basically our second home during the next week. They also warned us about reindeers, which are apparently quite stupid and will run towards your car whenever they get the chance. Unpacking and inventory of our experiment happened at the dome, a huge hangar where thecampaign preparations took place. Additionally, to the dome there was also the Hotel Aurora (the place where all of us were staying), the main building of SSC and some other small buildings.
Pic 2: OOXYGEN Experiment Setup without casing (left Childbox, middle EOS Chamber, right Motherbox), picture: Benjamin Altenstein
Saturday morning started off with a lot of troubleshooting, just as the night before. Team OOXYGEN found some major issues in their experiment, which could have led to the failure of the whole experiment. Luckily the electrical engineer and the computer scientist of our team continued working and debugging until a solution was found. Therefore only 13 of our 16 EOS-sensors (experimental oxygen sensors) could stay onboard, but therefore the whole system was able to run. The same night the three remaining members of the OOXYGEN team arrived at Esrange.Gamma-Volantis had the experiment assembly and some test scheduled for the day. The tests were performed to confirm the correct performance of the experiment and to test and calibrate the reference sensor. All components seemed to have survived their journey to Sweden and thankfully everything went smooth.
Bild 3: Experiment Setup Gucci-Volantis, bereits in die Gondel integriert, Bild: Frank Windeck
Troubleshooting lasted the whole next day and on October 21st it was time to set up a sequence for the gondola mounting test. Team OOXYGEN volunteered to be the first experiment, which will be mounted to the gondola BEXUS 28, afterwards it should be Gamma-Volantis turn. In total there would be five experiments mounted on BEXUS 28. Some more problems occurred, and integration got more and more delayed. Gamma-Volantis had connection issues between their ground station and experiment, which could be fixed by one of the friendly SSC members. On BEXUS 28 not only the experiments from Dresden had some difficulties. The Italian team TARDIS from Sapienza University in Rome and the students of team DESTINY from Ecole Polytechnique from Paris had software concerns as well. The Swedish team IRISC from Kiruna had hardware problems, after dropping their Raspberry Pi several times.
Pic 4: Sunrise at Esrange at -14°C, picture: Benedikt Boos
The teams whose experiments were mounted to gondola BEXUS 29 had fewer problems. TANOS, SHADE, R2-C2 and IROCS were integrated quite seamlessly and therefore the gondola was ready to launch at the next possible launch window. Launch was set to 6 am on October 23rd and the balloon took off at 6:33 am into the dark sky, which was covered in only a few clouds.
Pic 5: BEXUS 29 launch, picture: Benedikt Boos
The teams of BEXUS 28 kept working and after a few busy days and night shifts the last screws were set into place on October 23rd on the OOXYGEN experiment. The interference test was scheduled for the same day. All experiments were mounted to the gondola and to detect if any experiment affected the communication of others adversely. The test was completed successfully.
Pic 6: despair in team OOXYGEN, picture: Karina Einicke
FCT (flight compability testing) was scheduled for the next morning. The test confirmes the communication of ground station and experiment as well as if the experiment is ready to fly. The godola with all experiments was brought to the launch site and it was the first time the experiments were expressed to the true environmental conditions in Sweden. Unfortunately, there was loss of pressure in the nitrogen tank of the OOXYGEN experiment, which let the tank pressure of 150 bars drop within 50 minutes. With the change of the experiment execution this was thankfully not a big problem. The reparation of the lacking tank could have been fixed by tightening a valve, which would only be possible if we dismounted the experiment. If the experiment would have had to be changed and maybe had to be dismounted from the gondola, the FCT with all experiments would have had to be repeated. After FCT there is no touching of the gondola allowed. After FCT the teams had to confirm the flight readiness of their experiments to SSC, ZARM, DLR and ESA. To be ready for the launch at 6 am the next morning, everybody went to bed quite early. The countdown for launch starts 4 hours before launch and the teams had to be at least 30 minutes early at the dome to set up their ground stations.
Pic 7: all experiments mounted to the gondola (left GV, top right OOXYGEN, bottom right DESTINY), picture: Nils Hensch
A bunch of alarms went of at 1 am on October 25th. A few minutes later the team members were on their way to the dome through the freezing cold snow. Four hours countdown went by very quickly, there was always testing and some other small things to do. Around 4 am the late access team was on their way to the balloon to take final measures on the experiments. The night was too foggy for the students to see anything from the dome and the only updateswe got on the launch were rare and via WhatsApp. At 6:22am the BEXUS 28 balloon launched with the experiments OOXYGEN, Gamma-Volantis, DESTINY, IRISC and TARDIS onboard into the dark sky, starting its journey eastwards. Shortly after launch the first data was received by the ground stations. The OOXYGEN experiment began the measurement cycles as expected and at the first glimpse Gamma-Volantis looked promising as well. After a while a failure of the GV sensors occurred and caused some low spirits. After 3 hours flight time the gondola was released from the balloon and started the journey back to the earth's surface with a parachute.
Pic 8: gondola on Hekules on the way to the sweet spot, picure: Frank Windeck
A lot of teams were disappointed, because not everything with the experiments went according to plan. Simon Mawn from ZARM (one of the payload managers) held a little motivational speech and complimented all of us to have launched an experiment into the stratosphere. This brought back the thoughts that a working experiment was not the whole purpose of all of our work, but to be able to make it to the point, where we are able to launch an experiment into the stratosphere. Of course, everybody wanted their experiment to work, but we can learn from our mistakes and are able to avoid them next time. We were able to take part in a BEXUS campaign which launched a balloon to up to 27000 meters and learneda lot of lessons.
Pic 9: Postflight Beer, picture: Elias Ortlieb
The same night SSC organized a campaign dinner with some entertainment provided by each team. We celebrated the launch of our experiments with delicious food, cheerfulness and a lot of very expensive Swedish alcohol...
On Saturday (October 26th) almost everybody slept till noon. We were awake more than 24h for the launch, campaign dinner and the afterparty and desperately needed some sleep. Some of us planned to do a little hike through the beautiful area, but those plans were canceled due to a short notice guided tour to the rocket launch pad. The same day there was a failed recovery attempt for the BEXUS 28 gondola, due to heavy snow and clouds in Finland. During another team meeting the recovery was scheduled for Monday. Therefore, one team member had to stay in Sweden for the dismounting of the experiment.
Pic 10: Skylark Tower with launch platform, picture: Benedikt Boos
At 4 am on Sunday (October 28th) the bus took us to the airport in Kiruna, where all the teams took a plane to get back home.
Pic 11: Gondel Recovery in Finnalnd, Foto: Simon Mawn
Back in Dresden we are waiting for the onboard data of the experiment to the final evaluation of the sensor data. BEXUS was a great and once (maybe and hopefully twice) in a lifetime experience, which let our teams grow together and gave us the chance to gain a lot of new skills.
We really want to thank Simon, Dieter, Stefan, Kathi, Alex, Rodrigo, Paolo, Michael, Arthur, the people from Esrange, from the Center of Applied Space Technology and Microgravity (ZARM), from the German Aerospace Center (DLR), from the Swedish Space Corporation (SSC), from the Swedish National Space Agency (SNSA) and from the European Space Agency (ESA). And we were proud to fly with all the other teams!
Per aspera ad astra – Seneca
Text: Benedikt Boos
This entry was posted in BEXUS, Gamma-Volantis, OOXYGEN and tagged Bexus, DLR, ESA, Esrange, Gamma-Volantis, Kampagne, OOXYGEN, SSC. Bookmark the permalink.
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Be Amazing Dress by Ellie and Mac is just that, amazing.
It's a twirly party dress that makes a great impression due to the addition of horsehair braid to the hemline. It was my first time using it and it was a challenge to find it here in the Netherlands.
The application was pretty straightforward, I had no problems with it. The pattern has very easy to follow instructions.
Even though Samantha is in a no-dresses phase, she loves this one and can't wait for it to get warmer so she can wear it.


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A Comprehensive Travel Guide to Singapore
Home Attractions Explore your divine self at the Sacred Buddha Tooth Relic Temple and...
Explore your divine self at the Sacred Buddha Tooth Relic Temple and Museum
By Bandita Bishi -
Singapore is a mixed pan of both history and modernity. Along with rich cultural history, Singapore graces a religious touch through the various divine monuments build which bears tremendous significance. One of such temples is the Buddha Tooth Relic Temple. The Buddha temple Singapore also has a museum attached to it which today has become one of the most popular tourist destinations. Often listed as one of the most photogenic attractions in and around the island due to its prime location in Chinatown, it has gained popularity among tourist all around the world.
The famous Buddha Tooth Relic Temple was built as a veneration place of worship of a tooth and is often known as one of the best places to visit for divinity. The tooth was by the Venerable Cakkapala while he was on a mission to restore a collapsed stupa in Burma, now Myanmar in 1980. On the discovery of the tooth in a solid gold stupa, his assistants placed it in the Bandula Monastery. It was in 2002 that the Venerable Cakkapala on an exhibition brought the relic to Singapore to celebrate the Golden Pagoda Temple's anniversary. Over 300,000 visitors who came to adore and worship the religious symbol, lead the Venerable Cakkapala to bestow the tooth relic to the Venerable Shi Fa Zhao. A monastery worthy of the remnant was built to worship for Buddhists to quickly view and show their respects to it. Thus The Tang-styled Chinese Buddhist temple, the Buddha Tooth Relic Temple was built in 2007 and has gained popularity since then both regarding endearment and enlightenment.
Interiors:
The temple's interiors are lavish in décor, and the large displays on Buddhist art and history signify numerous stories of culture which span over hundreds of years. The tooth relic temple symbolizes the Buddhist culture which represents the universe. The museum also known as the Buddhist Culture Museum is situated on the third floor. Esteemed artifacts of the Buddha, including relics of his body, can be found here.
A giant stupa weighing almost 3500 kilograms is where the Buddha Tooth Relic is placed. The temple made of nearly 320 kilograms of gold which has 234 kilograms donated by worshippers. One can view it from the public viewing are whereas only monks have access to the relic chamber. The Buddha prayer wheel on the roof garden offers the perfect tranquil hideaway from the hustle bustle of the busy Chinatown.
The temple Is also famous because since its inception as many worshippers believed to have found some insights into different forms of truth, wisdom and sincere compassion. The legacy of Buddha's teachings through different workshops has helped many devotees feel the divine presence and has helped them spiritually. The Buddha tooth relic temple is a great example where devotees believe that finding religious purpose is not as difficult as one might imagine. Though many may not achieve it since its work, the Universal wisdom hall, the many workshops catalyze severe thoughts into people to realize the strength of divinity in the sacred temple. Thus, making it one of the best places to visit for divinity.
Through the 'Discovering Buddhism' workshop travelers around the world have gained perspective into Buddhism and his teachings through various interactive workshops led by the temple's resident monks and volunteers. The Buddha tooth relic temple is of exceptional importance. Every devotee realizes the mandate, the mission they have on planet Earth. One part of it to be of help and service to fellow human beings. The religious teachings shared at the temple helps devotees have inexplicable passion and zest and compassion for life and people.
The Sacred temple allows the opportunity to realize that the divine purpose is within each devotee. The temple in the middle of the busy Chinatown serves as an excellent example to find tranquillity and accept the presence of mind and body. The teachings and chants also help discovers what powers people and make them aware. The tremendous amount of donations and voluntary services offered to signify this. The temple allows for a sacred place to practice promises guidance, peace, harmony. Through the tranquillity, people find their divine self with an illuminating light empowering with higher knowledge. Believers here at the sacred space have claimed to feel stronger to turn away from the distractions that emanate from the physical world. Spending time here at the temple has helped devotees restore self in the divine light and love and realize eternal bliss. Ideal for people who are looking to explore their divine self and fulfill their quest for inner peace. Through continuous meditation and chanting, worshippers have been enabled to find the higher path as it helps repel illusions, various desires, and worldly attachments that keep them trapped in lower vibration and on a lesser track.
Spending qualitative time here at the Buddha Tooth relic temple, devotees have supposedly gained a more exceptional ability to take cognizance of the limiting, disharmonious, and restricting energies and forms. The temple has several elements that make it one of the best places to visit for divinity.
There is no charge/free of cost to enter the temple. There are weekly-guided tours arranged and conducted free of charge by the volunteers who donate their time as temple guides, Each of these tours may last for around 2 hours. The temple guides instruct you as and when you move up the building, through various levels and halls of the Buddha Tooth Relic Temple. The Buddha Tooth relic temple has a Museum which is covered as well and includes the handcrafted Bodhisattva artworks exhibited on display in the Universal Wisdom Hall, and the hundred Buddha statues are seated in the Hundred Dragons Hall.
The temple's rich designed interiors and equally designed exteriors that include comprehensive exhibits on Buddhist art and history give you glimpses of the rich cultural history that is over a centuries old. One of the best places to visit for divinity that you should not miss out during your trip to Singapore.
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Bandita Bishi
http://www.singaporewikia.com
Bandita Bishi is a travel blogger who loves to explore and share her experience with others to keep them motivated to take a trip.
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Many of the scientists who worked on the Manhattan Project had families in Europe, or were refugees from Europe themselves, and so the atomic bomb they were helping to make had an obvious adversary in mind. When Germany surrendered, however, many felt much less animus against Japan, and in part this conflict is narrated in the voices below.
Thomas Jefferson: I know no safe depository of the ultimate powers of the society but the people themselves, and if we think them not enlightened enough to exercise that control with whole a wholesome discretion, the remedy is not to take it from them, but to inform them their discretion.
President Franklin Roosevelt, speaking at a Pan American Scientific Congress in Washington, 1940: You who are scientists may have been told that you are in part responsible for the debacle of today … but I assure you that it is not the scientists of the world who are responsible… What has come about has been caused solely by those who would use, and are using, the progress that you have made along lines of peace in an entirely different cause.
Robert Oppenheimer, on his political awakening in 1936: I had had a continuing, smouldering fury about the treatment of Jews in Germany. I had relatives there, and was later to help in extricating them and bringing them to this country.
Physicist Robert Wilson, on Robert Oppenheimer: Oppie would get a faraway look in his eyes and tell me that this war was different from any war ever fought before; it was a war about the principles of freedom…. He was convinced that the war effort was a mass effort to overthrow the Nazis and upset Fascism and he talked of a people's army and a people's war…. The language had changed so little. It's the same kind of [political] language, except that now it has a patriotic flavor, whereas before it had just a radical flavor.
Physicist Otto Frisch, recalling the moment in 1940 "when he understood a bomb might be possible after all": I have often been asked why I didn't abandon the project there and then, saying nothing to anybody. Why start on a project which, if it was successful, would end with the production of a weapon of unparalleled violence, a weapon of mass destruction such as the world had never seen? The answer was very simple. We were at war, and the idea was reasonably obvious; very probably some German scientists had had the same idea and were working on it.
Mathematician Stanislaw Ulam, on arriving with his brother in America: Our father and sister were in Poland, so were many other relatives. At the moment, I suddenly felt as if a curtain had fallen on my past life, cutting it off from my future. There has been a different color and meaning to everything ever since.
Robert Oppenheimer to Physicist I. I. Rabi: I do not think that the Nazis allow us the option of [not] carrying out that development.
Physicist Edward Teller: I came to the United States in 1935…. The handwriting was on the wall. At that time, I believed that Hitler would conquer the world unless a miracle happened. …To deflect my attention from physics, my full-time job which I liked, to work on weapons, was not an easy matter. And for quite a time I did not make up my mind…. If the scientists in the free countries will not make weapons to defend the freedom of their countries, then freedom will be lost.
Physicist Emilio Segre, upon hearing of Hitler's death: We have been too late.
Physicist Freeman Dyson on Joseph Rotblat: Rotblat saw no point in continuing to work on a weapon that was no longer needed to defeat Germany.
Physicist Robert Wilson, at various points: We did have a pretty intense discussion of why it was that we were continuing to make a bomb after the war had been [virtually] won.
I thought we were fighting the Nazis, not the Japanese particularly….
I would like to think now that at the time of the German defeat that I would have stopped, taken stock, thought it all over, and that I would have walked away from Los Alamos at that time. In terms of everything that I believed in, before, during, and after the war, I cannot understand why I did not make that act. On the other hand, it simply was not in the air, and I don't know of a single instance of anyone who made that suggestion, or who did leave. There might have been someone I didn't know, but at the time it just was not something that was part of our lives. Our life was directed to do one thing, as though we had been programmed to do that, and we, as automatons were doing it….
I felt betrayed when the bomb was exploded over Japan without discussion or some peaceful demonstration of its power to the Japanese.
Robert Oppenheimer: When you see something that is technically sweet, you go ahead and do it and you argue about what to do about it only after you have had your technical success. That is the way it was with the atomic bomb. I do not think anybody opposed making it; there were some debates about what to do with it after it was made.
Physicist Hans Bethe, on the atmosphere at Los Alamos: But I have never observed in any one of these other groups quite the spirit of belonging together, quite the urge to reminisce about the days of the laboratory, quite the feeling that this was really the great time of their lives. That this was true of Los Alamos was mainly due to Oppenheimer. He was a leader.
Physicist Freeman Dyson, on Oppenheimer: Restlessness drove him to his supreme achievement, the fulfilment of the mission of Los Alamos, without pause for rest or reflection.
Physicist Victor Weisskopf: the thought of quitting did not even cross my mind.
Joseph Grew, U. S. Ambassador to Japan: Victory or Death is no mere slogan for these soldiers. It is plain, matter-of-fact description of the military policy that controls their forces, from the highest generals to the newest recruits. The man who allows himself to be captured has disgraced himself and his country.
Marine General Alexander A. Vandegrift, fighting at the time in the Solomons and Guadalcanal: I have never heard or read of this kind of fighting. These people refuse to surrender. The wounded will wait until me come up to examine them … and blow themselves and the other fellow to death with a hand grenade.
Journalist Henry C. Wolfe, in Harper's, who called for the firebombing of Japan's "inflammable" "matchbox" cities: It seems brutal to be talking about burning homes. But we are engaged in a life-and-death struggle for national survival, and we are therefore justified in taking any action that will save the lives of American soldiers and sailors. We must strike hard with everything we have at the spot where it will do the most damage to the enemy.
Physicist I. I. Rabi, seeing Robert Oppenheimer after the Trinity Test on July 16, 1945, the first detonation of a nuclear weapon in the Jornada del Muerto desert of New Mexico: He was in the forward bunker. When he came back, there he was, you know, with his hat. You've seen pictures of Robert's hat. And he came to where we were in the headquarters, so to speak. And his walk was like "High Noon"—I think it's the best I could describe it—this kind of strut. He'd done it.
Robert Oppenheimer, remembering the Trinity Test years later: We waited until the blast had passed, walked out of the shelter and then it was extremely solemn. We knew the world would not be the same. A few people laughed, a few people cried. Most people were silent. I remembered the line from the Hindu scripture, the Bhagavad-Gita: Vishnu is trying to persuade the Prince that he should do his duty and to impress him he takes on his multi-armed form and says, "Now I am become Death, the destroyer of worlds." I suppose we all thought that, one way or another.
Physicist Robert Wilson's words, after the Trinity Test, to fellow scientist Richard Feynman: It's a terrible thing we made.
Henry Stimson, American Secretary of War: My chief purpose was to end the war in victory with the least possible cost in the lives of the men in the armies which I had helped to raise. In the light of the alternatives, which on a fair estimate, were open to us I believe that no man, in our position and subject to our responsibilities, holding in his hands a weapon of such possibilities for accomplishing this purpose and saving those lives, could have failed to use it and afterwards looked his countrymen in the face.
Robert Oppenheimer's boss, General Leslie Groves, head of the Manhattan Project: I had set as the governing factor that the targets chosen should be places the bombing of which would most adversely affect the will of the Japanese people to continue the war. Beyond that, they should be military in nature, consisting either of important headquarters or troop concentration, or centers of production of military equipment and supplies. To enable us to assess accurately the effects of the bomb, the targets should not have been previously damaged by air raids. It was also desirable that the fire target be of such size that the damage would be confined with in, so that we could more definitely determine the power of the bomb.
An Air Force document recommending Kyoto and Hiroshima as atomic bomb targets: (1) Kyoto. The target is an urban industrial area with a population of 1,000,000. It is the former capital of Japan and many people and industries are now being moved there as other areas are being destroyed. From the psychological point of view there is the advantage that Kyoto is an intellectual center for Japan and the people there are more apt to appreciate the significance of such a weapon as the gadget. (2) Hiroshima. This is an important army depot and port of embarkation in the middle of an urban industrial area. It is a good radar target and it is such a size that a large part of the city could be extensively damaged. There are adjacent hills which are likely to produce a focusing effect which would considerably increase the blast damage. Due to rivers it is not a good incendiary target.
After Germany was ruled out as a target, and after a handful of staged "demonstrations" of what an atomic bomb was capable of was also ruled out, a Scientific Panel of the Interim Committee—which included Ernest Lawrence, Enrico Fermi, Oppenheimer, and Arthur Compton, said this: Those who advocate a purely technical demonstration would wish to outlaw the use of atomic weapons, and have feared that if we use the weapons now our position in future negotiations will be prejudiced. Others emphasize the opportunity of saving American lives by immediately military use, and believe that such use will improve the international prospects, in that they are more concerned with the prevention of war than with the elimination of this specific weapon. We find ourselves closer in these latter views; we can propose no technical demonstration likely to bring an end to the war; we see no acceptable alternative to direct military use.
General Dwight Eisenhower, remembering talking with Henry Stimson in July, 1945: The cable was in code, you know the way they do it. "The lamb is born" or some damn thing like that. So then he told me they were going to drop it on the Japanese. Well, I listened, and I didn't volunteer anything because, after all, my war was over in Europe and it wasn't up to me. But I was getting more and more depressed just thinking about it. Then he asked me for my opinion, so I told him I was against it on two counts. First, the Japanese were readying to surrender and it wasn't necessary to hit them with that awful thing. Second, I hated to see our country be the first to use such weapons. Well … the old gentleman got furious. And I can see how he would. After all, it had been his responsibility to push for all the huge expenditure to develop the bomb, which of course he had a right to do, and was right to do. Still, it was an awful problem.
Robert Oppenheimer, the evening after Hiroshima was bombed, speaking to a "cheering, foot-stamping audience" gathered in a Los Alamos auditorium: [it was] too early to determine what the results of the bombing might have been, but he was sure that the Japanese didn't like it.
Robert Oppenheimer to his former teacher, after Hiroshima: You will believe that this undertaking has not been without its misgivings; they are heavy on us today, when the future, which has so many elements of high promise, is yet only a stone's throw from despair.
Robert Oppenheimer to his old friend, Haakon Chevaliar, after Hiroshima: Circumstances are heavy with misgiving, and far, far more difficult than they should be, had we power to re-make the world to be as we think it.
Robert Oppenheimer, after Hiroshima, said to a military reporter that he was a "little scared of what I have made," but immediately added: A scientist cannot hold back progress because of fears of what the world will do with his discoveries.
Peter Goodchild, on the scientists of Los Alamos following Hiroshima and Nagasaki: For years most of the men at Los Alamos had been caught up in the excitement of the technical challenge and had given so little thought to the consequences of their action. Their celebration marked the profound relief that a monumental task had been achieved, but at the same time there was a realization of the awfulness of what they had done. That night, as Oppenheimer walked away from the celebrations, he came across one of the younger scientists stone cold sober retching into the bushes.
Alice Kimball Smith, wife of one of the Los Alamos scientists: As the days passed, the revulsion grew, bringing with it—even for those who believed that the end of the war justified the bombing—an intensely personal experience of the reality of evil.
Robert Oppenheimer, on the scientists at Los Alamos in October, 1945: all they think about now are the social and economic implications of the bomb.
Robert Oppenheimer speaking to Los Alamos scientists on October 16, 1945: Today that pride must be tempered with a profound concern. If atomic bombs are to be added as new weapons to the arsenals of a warring world, or to the arsenals of nations preparing for war, then the time will come when mankind will curse the names of Los Alamos and Hiroshima. The peoples of the world must unite, or they will perish. This war, that has ravaged so much of the earth, has written these words. The atomic bomb has spelled them out for all men to understand. Other men have spoken them, in other times, of other wars, of other weapons. They have not prevailed. There are some, mislead by a false sense of human history, who hold that they will not prevail today. It is not for us to believe that. By our works we are committed, committed to a world united, before the common peril, in law, and in humanity.


A Nigerian man and his Indian wife have been arrested in Delhi, for allegedly duping several people in the name of customs clearance for gifts received on their behalf them.
The cyber cell of the Delhi police arrested Ifeanyi Joachin Nwafor and his wife from Dabri area on Monday and seized cash worth R 6.69 lakh along with 12 mobile phones and two laptops.
According to a complaint lodged by one of the victims, a social worker, a supposed UK-based man named George Moor added her on social networking site Facebook a few months ago. He requested her to accept a few gifts for the poor people in India.
A few days later, the complainant said, she received a call from an unknown woman, who claimed to be a customs officer in Mumbai, and said that a parcel had been received from the UK for clearance and she would have to pay a sum of R 26,000 as customs duty.
On July 10, the complainant deposited that amount in the bank account provided by that unknown woman.
However, the woman had told the complainant that the parcel contained valuable items so she would have to pay Income Tax, and on the next day, she deposited R 95,600, the complainant said.
After receiving several calls for the money, the woman reported the matter to the police and filed a complaint, the police said.
After analysing the mobile numbers, the police noticed that the accused persons had visited Assam last December, and they took out a list of passengers of all flights from New Delhi to Dimapur and from Guwahati to New Delhi.
The police also obtained the details of bank accounts wherein the money had been deposited.
The police also got the details of those ATMs from where the accused persons used to withdraw the amount and analysed the footage of CCTV cameras installed in the area, the police said.
"During interrogation, it was found that Nwafor is from Nigeria and in 2009, he had come to India on a business visa. In 2012, he came in contact with the woman (co-accused) through Facebook, who is from Assam, and later they started living together in Delhi. They got married later in the country," DCP (Dwarka) Anto Alphonse said.
"Nwafor has made several fake Facebook accounts and made friends through them. The duo used to approach people through social media. After taking them into confidence, he used to tell his Facebook friends about sending precious gifts for them," he said.
"Later, his wife called those victims and introduced herself as a customs officer and used to convince them to deposit money into a particular bank account. When the money was deposited, they withdrew it within hours," the DCP added.


The Institution encourages the MBA and PGDM faculty members to conduct research both in the area of their choice and interest to integrate latest knowledge. A faculty member is eligible (appointed by Management as a full time faculty) to undertake research depending upon his interest and specialization. Research includes practical views of experienced personalities, observations, critical interpretations and elaborative analysis. Research also comprises of knowledge creation, compilation and its communication through text books, reference books, study materials, monographs etc. In addition, research includes innovative and creative initiatives undertaken for the benefit of the academicians and society at large.
Institution is expecting that the Researchers should contribute original literature either for a research paper or for a case study. The Research Committee endevours to check the originality of the literature before suggesting any publication by going through Urkund Plagiarism Software. The Chairman is authorized to expand additional members in Research Committee depending upon scope of research.
Institution is allowing faculty members for Publication of Research Papers, Case Studies, Research Articles in reputed National or International Journals or in journals approved by UGC and for presentation of the same in State, National or International Level Conferences, Workshops and Seminars.
Institution is also supporting faculty members in deciding priorities of research activities and projects, to develop linkage with affiliating University for conducting research under QIP and BCUD Funded Research Projects, UGC and other agencies Funded Research Projects.
Institution provides Financial Grant and Paid Leave for attending Conference, Workshop, Seminar, FDP and MDP to eligible members of the faculty. Faculty member who desires to conduct FDP / MDP / Training Programme / Consultancy outside the Institution for any organization should conduct the same with approval of Dean Academics / Director. The remuneration received should be shared in the ratio of 70:30 between employee and employer respectively.
The selection of the faculty is done on the basis of the merit and the experience of the faculty for any external and in-house Training/FDP/MDP, Conferences, Workshops and Seminars at State, National or International Level. After the training, concerned faculty member should share his feedback and inputs of training and research work with complete details to all departmental staff members and students.


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COMORBIDITIES IN PRACTICE. CLINICAL GUIDELINES
Association of General (Family Care) Practitioners (Russian national registered charity). Section "Comorbidities"
Workgroup: R. G. Oganov (Co-chair) (Moscow), I. N. Denisov (Co-chair) (Moscow), V. I. Simanenkov (Coordinator) (Saint-Petersburg), Bakulin I. G. (Saint-Petersburg), Bakulina N. V. (Saint-Petersburg), Boldueva S. A. (Saint-Petersburg), Barbarash O. N. (Kemerovo), Garganeeva N. P. (Tomsk), Doshchitsin V. L. (Moscow), Drapkina O. M. (Moscow), Dudinskaya E. N. (Moscow), Kotovskaya Yu. V. (Moscow), Lila A. M. (Saint-Petersburg), Mamedov M. N. (Moscow), Mardanov B. U. (Moscow), Miller O. N. (Novosibirsk), Petrova M. M. (Krasnoyarsk), Pozdnyakov Yu. M. (Moscow),
Runikhina N. K. (Moscow), Sayganov S. A. (Saint-Petersburg), Tarasov A. V. (Moscow), Tkacheva O. N. (Moscow), Urinsky A. M. (Moscow), Shalnova S. A. (Moscow).
Key words: cardiovascular disease, cardiovascular continuum, comorbid pathology, metabolic syndrome, geriatric comorbidity, primary and secondary prevention, rational pharmacotherapy.
THE DYNAMICS OF LIFE QUALITY PARAMETERS WITH NICORANDIL USAGE IN STABLE CORONARY HEART DISEASE PATIENTS (RESULTS OF THE OBSERVATION STUDY "NIKEA")
Martsevich S. Yu.1, Lukina Yu. V.1, Kutishenko N. P.1, Akimova А. V.1, Voronina V. P.1, Lerman О. V.1, Gaisenok О. V.2, Gomova Т. А. 3, Ezhov А. V.4, Kuimov А. D.5, Libis R. А.6, Matyushin G. V.7, Mitroshina Т. N. 8, Nechaeva G. I.9, Reznik I. I.10, Skibitsky V. V.11, Sokolova L. А.12, Chesnikova А. I.13, Dobrynina N. V.14, Yakushin S. S. 14 on behalf of the workgroup of NIKEA study*
1 National Research Center for Preventive Medicine of the Ministry of Health. Moscow; 2FSBI Joint Hospital and Polyclinics of the President Administration. Moscow; 3SHI Tulskaya Oblast Clinical Hospital. Tula; 4FSBEI HE Izhevsk State Medical Academy. Izhevsk;5FSBEI HE Novosibirsk State Medical Academy. Novosibirsk;6Orenburg State Medical University (OrSMU). Orenburg; 7V.F.Voino-Yasenetsky Krasnoyarsk State Medical University. Krasnoyarsk; 8BHI of Orlovskaya Oblast Polyclinics № 3. Orel; 9FSBEI HE Omsk State Medical University. Omsk; 10 FSBEI HE Ural State Medical University. Ekaterinburg; 11FSBEI HE Kuban State Medical University. Krasnodar; 12Federal Almazov North-West Medical Research Centre of the Ministry of Health. Saint-Petersburg; 13Rostov State Medical University of the Ministry of Health. Rostov-na-Donu; 14FSBEI HE I. P. Pavlov Ryazan State Medical University. Ryazan, Russia
Aim. In the circumstances of real clinical practice, to evaluate the changes in life quality (LQ) parameters of the patients with coronary heart disease and stable angina with addition of nicorandil to standard treatment.
Material and methods. Study design — prospective, observational, multicenter. In the trial, the physicians participated, from 14 institutions in a range of Russia regions. Totally, 590 included: 261 (44,2%) females, 329 (55,8%) males. All patients, in addition to the standard antianginal treatment, were prescribed with nicorandil. At the visits V0 (baseline) and V3 (3 months of therapy) they completed Seattle questionnaire (SAQ) of LQ assessment. Five parameters were assessed: exercise intolerance, attacks frequency, stability, attitudes toward disease, treatment satisfaction. At the visit V0 417 questionnaires were completed (response 71%), at V3 — 454 (response 82%).
Results. The significant increase was demonstrated, for parameters by SAQ in 3 months of observation, the highest parameters, except the scale exercise intolerance, were found in the group taking nicorandil during 3 months of follow-up (p<0,05 for all scale SAQ comparing to the group refused taking nicorandil at baseline or stopped at various stages of the study). By 3 months of follow-up, 3 times increase was noted of the patients with minimal number of angina attacks or absence, and the part of patients found that their life quality is "excellent". Almost 4 times the part of patients raised by the stability parameter, and the amount by the score "treatment satisfaction" increased to 50,2%. Comparison of ranged SAQ parameters at V0 and V3 visits with Wilcoxon criteria, showed significant differences by all the scales of SAQ (р<0,0001).
Conclusion. Under the real practice circumstances there was significant increase of all LQ parameters by SAQ in 3 months of observation. Most prominent positive changes were noted in patients taking nicorandil during whole follow-up period, comparing to those not taking nicorandil or discontinued at various stages of the study.
Key words: coronary heart disease, angina pectoris, life quality, nicorandil.
Cardiovascular Therapy and Prevention, 2017; 16(6): 57–64
CHANGES IN THE MUCOSE OF UPPER GASTROINTESTINAL TRACT IN CORONARY HEART DISEASE
Magomedova B. M.1, Glebov К. G.2, Teplova N. V. 3, Kotovsky А. Е.1, Artamonova N. G.3
1 I.M. Sechenov First Moscow State Medical University of the Ministry of Health. Moscow; 2O. M. Filatov City Clinical Hospital №15. Moscow; 3N. I. Pirogov Russian National Research Medical University (RNRMU). Moscow, Russia
Aim. To assess the specifics of endoscopy presentation of mucosal lesions of upper gastrointestinal tract (UGIT) in patients with chronic coronary heart disease (CCHD) with no rhythm disorders and with atrial fibrillation (AF).
Material and methods. Esophagogastroduodenoscopy was done in 100 CCHD patients. All patients were selected to 2 groups comparable by age and gender. First group (n=50) included CCHD patients, the second (n=50) – CCHD with AF. The investigations were performed with videoendoscopic equipment by OLYMPUS systemic videocenters CV-150 and CV-180 EVIS EXERA II.
Results. Evaluating the results of endoscopy, in all 100 patients there were various changes of the mucose of UGIT. No statistically significant differences found, however in CCHD group with rhythm disorder there was noted slight predominance of patients with superficial gastritis, as erosions in anthral part of the stomach. One of explanation of the erosions is due to excessive drug intake per os, that could influence the mucose of UGIT.
Conclusion. All CCHD patients, who have been prescribed the therapy for main disease, are in need for preventive intake of the drugs protecting UGIT.
Key words: coronary heart disease, changes, mucose of upper gastrointestinal tract, atrial fibrillation, prevention.
PROGNOSIS OF ONE-DAY MORTALITY AND PROTEIN GROWTH AND DAMAGE FACTORS IN ACUTE CORONARY SYNDROME
Kayumova G. Kh.1,2, Razin V. А.2, Gimaev R. Kh. 2, Ruzov V. I.2, Arjamkina О. L.2, Gnoevykh V. V.2
1 LLC "VM Clinic", multiprofile hospital. Ulyanovsk; 2FSEI HE Ulyanovsk State University. Ulyanovsk, Russia
Aim. To perform comparative analysis of the pregnancy-associated plasma protein A and insulin-like growth factor 1 (PAPP-A and IGF-1) in blood plasma of patients with acute coronary syndrome (ACS). Prediction of 24-hour risk of fatal outcome in ACS.
Material and methods. The concentrations of PAPP-A and IGF-I were assessed in 71 ACS patients, mean age 57 y. o. In the study group, during 24 hours myocardial infarction (MI) was diagnosed in 44, unstable angina in 27, and 9 fatal outcomes. Also, the concentrations of PAPP-A and IGF-I were measured in comparison and control groups. Comparison consisted of 40 hypertension patients with stable ischemic heart disease. Controls were 20 almost healthy persons.
Results. In the study, there was increase of PAPP-A and IGF-I levels in ACS patients. In unstable angina patients PAPP-A is higher than in controls 3,56 times, and in MI patients 11,6 times. In MI, PAPP-A is 3,2 times higher than in unstable angina. In unstable angina patients there the highest levels of IGF-I, and 1,27 higher than in controls. In the study, we showed that IGF-I and PAPP-A levels in acute coronary pathology are linked to the outcome at the first day of the disease.
Conclusion. It is aim full to apply PAPP-A and IGF-I to urgent cardiology practice as an analyzer of atherosclerotic plaque instability in acute coronary events, as a factor of life and disease prognosis.
Key words: acute coronary syndrome, myocardial infarction, pregnancy associated plasma protein A, insulin-like growth factor 1, coronary heart disease, unstable angina.
SIGNIFICANCE OF THE ALGORITHMS ON MINIMIZATION OF RIGHT-VENTRICULAR ELECTROSTIMULATION IN PREVENTION OF ATRIAL FIBRILLATION PROGRESSION IN PATIENTS WITH SICK SINUS SYNDROME
Ivanchina А. Е.1, Kopylov F. Yu.1, Samoilenko I. V.1,2, Syrkin А. L.1, Serova М. V.1
1 I.M. Sechenov First Moscow State Medical University of the Ministry of Health. Moscow; 2SBHI City Clinical Hospital № 4. Moscow, Russia
Aim. To assess the efficacy of algorithms for minimization of the rightventricular stimulation (MVS) for prevention of atrial fibrillation (AF) progression in patients with sick sinus node syndrome (SSS) and documented AF in anamnesis, comparing to standard bi-chamber electrical stimulation (DDDR).
Material and methods. The study was one-center, prospective, randomized trial with consequent 74 patients inclusion, who had indications to permanent DDDR due to SSS and AF in anamnesis. Patients were randomized to DDDR group (n=36) and active MVS (n=38) group. Procedure of electrocardiostimulator (ECS) maintenance was done at 6 months and 1 year. During follow-up visits, information was saved in the ECS memory, as the data on AF burden. Primary endpoints were AF burden and time to persistent AF onset.
Results. During the study, there were no significant differences in AF burden between the groups. Median of AF burden was 6,0 min/day (25-75 percentiles: 0-42 min/day) in DDDR, and 6,0 min/day (25-75 perc.: 0-42 min/day; p=0,67) in MVS group. Persistent AF development was registered in 5 patients, of those 3 (8,6%) in DDDR and in 2 (5,3%) in MVS (HR 1,25; 95% CI 0,2-7,98; p=0,47). Medication or electrocardioversion was done for 9 (25,7%) patients from DDDR and 12 (31,6%) from MVS groups (HR 0,86, 95% CI 0,31-2,38, p=0,39).
Conclusion. There was no benefit of MVS algorithms in short term period in decrease of AF burden and in its progression prevention towards persistent AF in SSS patients with the anamnesis of paroxysmal AF, comparing to standard DDDR regimen of ECS.
Key words: atrial fibrillation, sick sinus syndrome, dual chamber pacemaker, minimized right ventricle stimulation.
PROGNOSTIC SIGNIFICANCE OF GALECTIN-3 LEVEL ASSESSMENT IN METABOLIC SYNDROME PATIENTS WITH HEART FAILURE
Drapkina О. М.1, Shepel R. N.1, Deeva Т. А. 2
1 National Research Center for Preventive Medicine of the Ministry of Health. Moscow; 2I.M. Sechenov First Moscow State Medical University of the Ministry of Health. Moscow, Russia
Aim. To assess the level of galectin-3 in blood serum of metabolic syndrome patients (MS), with heart failure (CHF).
Material and methods. Totally, 43 patients investigated, with MS, and of those 37 CHF patients and 33 on-CHF, of those 17 had CHF diagnosed. Galectin-3 level in blood serum was measured by immune enzyme assay.
Results. Galectin-3 level in blood plasma of MS patients was significantly higher comparing to the group with no MS — 1,89±1,71 ng/mL and 1,03±0,22 ng/mL, respectively. In the control group maximum galectin-3 level was 1,5 ng/mL, but in MS group 27% had galectin-3 higher than 3 ng/mL. It was found that mean levels of galectin-3 were significantly higher in CHF group (1,73±1,59 ng/mL) comparing to non-CHF (1,05±0,26 ng/mL).
Conclusion. Level of galectin-3 in MS patients is higher than in those non-MS, but in MS and CHF galectin-3 concentration is higher than non-CHF. Further elaboration on this relationship might be useful in improvement of CHD and MS diagnostics.
Key words: galectin-3, metabolic syndrome, chronic heart failure.
GENDER DIFFERENCE AND COMORBIDITIES IN CHRONIC HEART FAILURE PATIENTS
Shukurov R. T., Abdullaev T. A.
JSC "Republic Specialized Cardiology Center". Tashkent, Uzbekistan
Aim. Investigation and analysis of clinical-hemodynamic signs of chronic heart failure (CHF) at the age 42-89 y. o., including the assessment of gender and comorbidities, according to ejection fraction (EF) of the left ventricle (LV): preserved EF LV ≥45% (HFpEF) and low EF LV <45% (HFrEF).
Material and methods. Totally, 120 CHF patients studied, age 42-89 y. o., with assessment of gender and comorbidities, accoring to ejection fraction (EF) of the left ventricle (LV): preserved EF LV ≥45% (HFpEF) and low EF LV <45% (HFrEF).
Results. In most cases the etiology of CHF was coronary heart disease (CHF) — 58,8%, and in 68,3% cases it was comorbid with arterial hypertension (AH). Assessment of CHF in patients with various EF LV showed that in both groups males predominated. In HFrEF there were more overweight patients (41,1%) and in HFpEF — obesity patients (51,6%). In HFrEF patients main factors leading to myocardial impairment were myocardial infarctions in anamnesis (91,1%), and in HFpEF — CHD with AH (81,3%), obesity (51,6%) and diabetes (43,8%). Extracardiac comorbidity in HFrEF was mostly chronic obstructive pulmonary (26,8%) and obliterate atherosclerosis of lower extremities arteries (17,9%), and HFpEF — congestion pneumonia (23,4%) and varicose vein disease (34,4%).
Conclusion. Patients with HFrEF — are mostly the CHD patients having risk factors: smoking, alcohol overconsumption, excessive physical exertion. HFpEF patients are mostly CHD+AH, most of them hadmetabolic disorders. Most cases of varicose vein disease and pneumonia in HFrEF can be explained by obesity and increased rate of diabetes. Cases of vascular dementia in HFpEF patients are related to higher prevalence of AH and its complications.
Key words: heart failure, ejection fraction, left ventricle, comorbidity.
INFLUENCE OF COMORBIDITIES ON BLOOD ALDOSTERONE LEVEL IN CHRONIC HEART FAILURE WITH PRESERVED SYSTOLIC FUNCTION OF THE LEFT VENTRICLE
Vatutin N. T.1,2, Shevelyok А. N.1,2
1 M. Gorky Donetsk National Medical University. Donetsk; 2V. K. Gusak Institute of Urgent and Reparative Surgery. Donetsk, Ukraine
Aim. To analyze relation of blood aldosterone level with comorbidities in patients with chronic heart failure (CHF) with preserved ejection fraction of the left ventricle (EF LV).
Material and methods. To the cross-sectional study, 158 patients included: 58 males, 100 females, mean age 62,3±7,4 y. o., with decompensated CHF with preserved EF LV (>50%) and diastolic dysfunction. Patients did not present with primary hyperaldosteronism and did not take mineralocorticoid antagonists within previous 6 weeks. All patients underwent blood specimens collection, and were assessed on the comorbid disorders and conditions. Reference values of the hormone were 40-160 pg/mL.
Results. According to the measurements, all patients were selected to two groups: I group included 99 (67,1%) of patients, who had normal hormone level; II — 59 (37,3%) patients with hyperaldosteronemia. Group II patients were younger — 57,75±7,5 y. o. vs 65,02±7,1 y. o. (p<0,001) and had more prominent presentation of the CHF (NYHA III) — 62,7% vs 33,3% cases (p<0,001) comparing to the group I. The prevalence of previus myocardial infarction was — 59,3% vs 41,4% (p=0,044), comorbid atrial fibrillation — 33,9% vs 17,2% (p=0,027), long-term (>10 years) arterial hypertension (AH) — 57,6% vs 25,3% (p<0,001), chronic obstructive lung disease (COLD) — 27,1% vs 7,1% (p=0,001), diabetes mellitus — 39,0% and 19,2% (p=0,011), obesity — 64,4% and 29,3% (p<0,001), and renal dysfunction — 88,1% and 50,5% (p<0,001) in the group II significantly higher than in group I. Multiple regression showed that after correction by age and severity of CHF, only long lasting AH, COLD, obesity and renal dysfunction were associated with hyperaldosteronemia.
Conclusion. In CHF with preserved EF LV patients, aldosterone level is closely linked with comorbidities. Long term anamnesis of AH, presence of COLD, obesity and renal dysfunction are independent factors for the risk of secondary hyperaldosteronism.
Key words: aldosterone, renin-angiotensin-aldosterone system, arterial hypertension, chronic obstructive pulmonary disease, obesity, renal dysfunction.
Syndrome of connective tissue dysplasia
SIGNIFICANCE OF THE FALSE CHORDS IN THE LEFT VENTRICLE FOR DIAGNOSTIC APPROACHES IN CHILD CONNECTIVE TISSUE DYSPLASIAS
Timokhina V. E.1,2, Mekhdieva К. R.1, Cherednichenko А. М.2,3, Blyakhman F. А.1,3
1 FSAEI HE Ural Federal University named after the First Russia President Eltsin B. N. of the Ministry of Education and Science. Ekaterinburg;2MAI Pediatric City Clinical Hospital № 11. Ekaterinburg; 3FSBEI HE Ural State Medical University of the Ministry of Health. Ekaterinburg, Russia
Aim. The study was aimed on the importance evaluation of the false chords (FC) diagnostics in the left ventricle (LV) of the heart at early age to predict connective tissue dysplasia (CTD) development.
Material and methods. The study performed at cardiorheumatological department of MAI "CCCH №11" of Yekaterinburg city. Case histories of 200 patients analyzed, of those had undergone treatment in the department last 6 months. Group consisted of children aged 1 month to 17 year old, mean age 9,7±4,6 y. o. Phenotype of CTD was evaluated according to the Gent score criteria (2010) and the Score by Kadurina T. I. et al. Heart structure and functioning were assessed with bi-dimensional transthoracic echocardiography. Statistics was done with SPSS Statistics 17.0 and Microsoft Office Excel 2013.
Results. All children had phenotype markers of CTD syndrome. Significance assessment of CTD by Kadurina score was 8,1±3,8 (2-33) points, that is grade 1 severity of CTD. In 17% (n=34) of children there was moderate CTD grade, and in 10% (n=20) there were dysplastic changes in ≥3 organ systems. Most of patients (95,5%) had FC (2,0±0,5 U) localized in various areas of the LV. Chords always correlated with phenotypic CTD markers in other physiological systems. And the number of concomitant markers significantly increased with the children's age.
Conclusion. In most cases CTD syndrome is associated with the changes in the heart, and FC in LV can be regarded as easy approachable and most early and reliable phenotypical marker of this systemic disorder.
Key words: connective tissue dysplasia, left ventricle, false tendons, pediatric cardiology, diagnostics, prevention medicine.
Cardiovascular therapy and prevention, 2017; 16(6): 99–104
DIAGNOSTIC SIGNIFICANCE OF VASCULAR ENDOTHELIAL GROWTH FACTOR IN PATIENTS WITH PRIMARY MITRAL VALVE PROLAPSE
Yagoda A. V.1, Gladkikh N. N.1, Zangelova Т. E.2
1 FSBEI HE Stavropol State Medical University of the Ministry of Health. Stavropol; 2SBHI SK Stavropolsky Kray Clinical Hospital. Stavropol, Russia
Aim. To evaluate diagnostic significance of the type A vascular endothelial growth factor (VEGF-A) and its receptors type 1 and 2 (VEGF-R1 and VEGF-R2) in primary mitral valve prolapse (MVP) patients.
Material and methods. Totally, 83 MVP patients studied: 61 males, 22 females; mean age 21,93±4,22 y. o. The signs of systemic inflammation were assessed, as the grade of connective tissue involvement. Immune enzyme analysis was done for serum levels of VEGF-А, VEGF-R1 and VEGF-R2 ("Bender MedSystems GmbH", Austria). Controls included 20 healthy volunteers — 14 males, 6 females, mean age 21,10±0,55 y. o. with no MVP and any other dysplastic features.
Results. In the MVP group, the decreased levels of circulating VEGF-R1 were found, as the increase of cases number of high (42,17%) and low (32,53%) concentration of VEGF-А. In low levels of VEGF-A and VEGF-A/VEGF-R1 prevalence of grade II mitral regurgitation increases 5,1 times comparing to the group of retained balance of VEGF-A and VEGF-R1 — 95% confidence interval (CI) 1,25-20,88, and the prevalence of clinically significant cardiac rhythm and conduction disorders increases 5,25 times in comparison to the cases with elevated VEGF-A and VEGF-R1 — 95% CI 1,33-20,76 and 4,09 times — comparing MVP patients with retained balance of VEGF-A and VEGF-R1 — 95% CI 1,18-14,17.
Conclusion. In primary MVP patients, regardless clinical phenotype of monogenic hereditary syndromes, the heterogeneity of deviation and regulation of VEGF has been established. Highest number of II grade mitral regurgitation, significant rhythm disorders was found in the group with low VEGF-A and VEGF-A/VEGF-R1, that might be implemented as optimized risk stratification in heterogenic MVP patients population.
Key words: mitral valve prolapse, vascular endothelial growth factor type A, receptors to vascular endothelial growth factor, risk stratification.
Cardiovascular therapy and prevention, 2017; 16(6): 105–110
Treatment of cardiovascular diseases
EVALUATION OF BETA-ADRENOBLOCKERS TREATMENT IN CARDIOVASCULAR DISEASES COMORBID WITH DIABETES IN OUTPATIENT SETTING
Komkova N.А.1, Zagrebelny А.V.1, Lukina Yu.V.1, Lukyanov М. М.1, Vorobyov А. N.2, Pereverzeva К . G.2, Kutishenko N. P.1, Kiseleva N. V.1, Martsevich S. Yu.1 on behalf of the worgroups of the PROFILE* and RECVAZA** registries
1 National Research Center for Preventive Medicine of the Ministry of Health. Moscow; 2FSBEI HE I. P. Pavlov Ryazan State Medical University. Ryazan, Russia
Aim. To evaluate the practice of beta-blockers (BB) usage in cardiovascular disease (CVD) patients with diabetes (DM) in two outpatient registries.
Material and methods. Registry PROFILE is the patients (n=1531) with CVD, visited specialized cardiological department of medical research center of Moscow during the period 2011-2015, and registry RECVAZA — patients (n=3690), visited 3 city polyclinics in Ryazan city in 2012-2013. Number of DM patients is 221 (14,4%) in PROFILE and 699 (18,9%) in RECVAZA.
Results. In the RECVAZA, the rate of BB prescription was almost the same in CVD and DM; in PROFILE there was significantly more frequent prescription of BB, especially after myocardial infarction (86,4%) and in chronic heart failure (72,6%). In both registries bisoprolol was in use most commonly: 61,8% in PROFILE and 75,4% in RECVAZA. Among DM
patients, not taking BB, in PROFILE registry there were additional contraindications: chronic obstructive pulmonary disease and asthma, than in RECVAZA.
Conclusion. Clinicians of the specialized cardiological department, comparing to clinicians in local outpatient institutions more actively prescribed BB to DM patients, especially in the cases when this could improve long-term outcomes of the disease. This matches with recent clinical guidelines.
Key words: beta-blockers, diabetes mellitus, registries, contraindications.
Epidemiology and рrevention
SMOKING AND CARDIOVASCULAR MORTALITY IN TOMSK INHABITANTS AS A TYPICAL CITY OF WESTERN SIBERIA
Efimova Е . V.1, Konobeevskaya I. N.1, Maksimenko G. V. 2, Karpov R. S.1
1 SRI of Cardiology of Tomsk National Research Medical Center. Tomsk; 2Medical Society "The Health". Tomsk, Russia
Aim. To investigate on the influence of cardiovascular diseases (CVD) on mortality in 25 thousand inhabitants of the typical city of Western Siberia.
Material and methods. Under the framework of international World Health Organization project "Epidemiological Studies into Long-term Trends of Population Health in Russia" with participation of 45 clinicians in medical institutions of the city, the cases of 26186 deaths were assessed, men and women 15-74 year old.
Results. The mortality from CVD was 34,9% and 44% in men and women; from coronary heart disease — 59,8% and 41,3%; from cerebrovascular disease — 29,2% and 39,9%, resp. Smoking was found in 68,7% men and 12% women; with the mean time of 41,3 and 38,9 years, respectively; smoking increased the risk 1,49-1,56 times. In the moderate and high tobacco consumption rates, risk of death increased (p<0,0001, p=0,002), as in any kind of smoking in economically active persons, more than 2 times. The decrease of life duration in smoking women and in lethal cases from coronary heart disease was 6,5 years (p<0,001), in men — 3,7 years; from CVD — 5,3 and 2,7 years, respectively.
Conclusion. The role of smoking was assessed in mortality from CVD, as the necessity confirmed for prevention of smoking at regional level.
Key words: smoking, cardiovascular mortality, relative risk of death.
CARDIOMETABOLIC DISORDERS AND UROLITHIASIS: PATHOGENESIS OF COMORBIDITY
Sharvadze G. G.1, Kerimov А. К.2, Mamedov М. N.1
1 National Research Center for Preventive Medicine of the Ministry of Health. Moscow, Russia; 2SBHI City Polyclinics № 212 MHD. Moscow, Russia
Comorbidity of chronic non-communicable diseases is actual problem of modern medicine. It was found, that metabolic syndrome (MS) is pathogenetically related with erectile dysfunction (ED), hypogonadism, gout and urolithiasis, that is an example of comorbidity. The article is focused on a wide spectrum of MS and urolithiasis relation. Taken high prevalence of urolithiasis and MS, scientists have found close correlation of MS cases with urolithiasys development. Most oftenly in MS patients urates are found. Pathophysiological mechanisms formulated for oxalates and mixed urolithes formation in MS patients. Therefore, in development of diagnostics, treatment and prevention algorithms of both disorders it is important to take into consideration the comorbidity.
Key words: comorbidity, metabolic syndrome, urolithiasis, insulin resistance, obesity, hypogonadism.
TREATMENT ADHERENCE AS AN ESSENTIAL ELEMENT OF CARDIOVASCULAR DISORDERS MANAGEMENT
Nebieridze D. V., Kamyshova T. V., Safaryan A. S., Sargsyan V. D.
National Research Center for Preventive Medicine of the Ministry of Health. Moscow, Russia
The article is focused on the issue of treatment adherence in cardiovascular patients, that is important due to chronic course of
cardiovascular diseases (CVD), necessity for long-term therapy and, also, seriously low adherence to treatment in this category of patients. The issues considered, on the objective assessment of adherence. Literature data provided, on the factors influencing adherence. The review focuses on recent data on the solutions of low adherence management in CVD patients. The recommendations given, on the ways for adherence improvement in real clinical practice.
Key words: cardiovascular diseases, arterial hypertension, high risk, treatment adherence.
THE STUDY OF LONGEVITY: RECENT UPDATES AND FURTHER DIRECTION. PART 2
Kotovskaya Yu. V.1,2, Tkacheva О. N.2, Runikhina N. К.2, Kashtanova D. А.2,3, Boytsov S. А.3
1 Peoples' Friendship University of Russia. Moscow; 2N. I. Pirogov Russian National Research Medical University (RNRMU) — SD "Russian Gerontological Scientific-Clinical Center". Moscow; 3National Research Center for Preventive Medicine of the Ministry of Health. Moscow; 4Russian Cardiological Research-and-Production Complex of the Ministry of Health. Moscow, Russia
Regardless the global demographic tendencies of life duration increase, longevity and super longevity remain quite understudied and non-fully understood population. Broader studies needed to understand, what it means to live by 100-year old. Lots of studies are about the longevity predictors and ways of ageing, that could be therapeutical targets not simply for life duration, but life quality as well, and medical-social geriatrics. The program "A Centenarian", being conducted by leading
scientific groups in Russia, is approaching a country unique medical, scientific and social data.
Key words: longevity, ageing, a centenarian, complex geriatrician assessment.
CARDIOCYTOPROTECTION PERSPECTIVES WITH ISCHEMIC PRECONDITIONING: HYPOXIA-INDUCED FACTOR 1 — POSSIBLE MOLECULAR MECHANISM AND TARGET FOR PHARMACOTHERAPY
Lyubimov A. V., Cherkashin D. V., Alanichev A. E.
FSBMEI HPE S. M. Kirov Military Medical Academy of MD RF. Saint-Petersburg, Russia
The article is focused on the analysis of modern fundamental studies of the preconditioning/preintervention phenomenon in coronary heart disease and heart failure. Brief prerequisites are given for the phenomenon assessment. Molecular and genetic base of the phenomenon presented, as the results of modern experimental works in the area of fundamental medicine and clinical observations of the patients with various cardiovascular diseases. Hypoxia-induced factor 1 — main pathogenetic adaptation factor for hypoxia — plays critical protection role in pathophysiology of coronary heart disease and heart failure, controlling and determining the supply and utilization of oxygen, regulating angiogenesis and vascular remodelling, glucose metabolism and redox exchange. Personalized medicine technology, based on the pharmacogenomics, pharmacoproteomics, makes it to implement fundamental discoveries in medicine to clinical practice.
Key words: hypoxia, cardioprotection, prevention, ischemic heart disease, personalized medicine.
NEW DIRECTIONS IN ATHEROSCLEROSIS PHARMACOTHERAPY
Dutova S. V., Saranchina Yu. V., Kilina O. Yu., Polshcha N. G., Kulakova T. C., Khanarin N. V.
FSBEI HE N. F. Katanov Khakassky State Medical University. Abakan, Russia
In the review, recent data presented, on possible targets for medications of specific pathogenetic action in atherosclerosis. The results described, of application of some drugs in complex treatment of atherosclerotic vessels lesions. The data can be applied for target development of antiatherosclerotic drugs with the aim of prevented progression of atherosclerosis and thromboembolic complications.
Key words: atherosclerosis, cytokines, enzymes, medications.
Jubile