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RHEA:12894
prostaglandin H2 => prostaglandin E2
Reaction with net flow from left to right. help_outline
Reaction information
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UniProtKB help_outline 1,774 proteins
Reaction participants Show >> << Hide
Name help_outline prostaglandin H2 Identifier CHEBI:57405 Charge -1 Formula C20H31O5 InChIKeyhelp_outline YIBNHAJFJUQSRA-YNNPMVKQSA-M SMILEShelp_outline CCCCC[C@H](O)\C=C\[C@H]1[C@H]2C[C@H](OO2)[C@@H]1C\C=C/CCCC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 11 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Name help_outline prostaglandin E2 Identifier CHEBI:606564 (Beilstein: 8364130) help_outline Charge -1 Formula C20H31O5 InChIKeyhelp_outline XEYBRNLFEZDVAW-ARSRFYASSA-M SMILEShelp_outline CCCCC[C@H](O)\C=C\[C@H]1[C@H](O)CC(=O)[C@@H]1C\C=C/CCCC([O-])=O 2D coordinates Mol file for the small molecule Search links Involved in 14 reaction(s) Find molecules that contain or resemble this structure Find proteins in UniProtKB for this molecule
Reaction direction help_outline undefined left-to-right right-to-left bidirectional
UniProtKB help_outline
2,254 proteins
EC numbers help_outline
Gene Ontology help_outline
KEGG help_outline
MetaCyc help_outline
PROSTAGLANDIN-E-SYNTHASE-RXN
Reactome help_outline
R-HSA-2161660.3
R-HSA-265295.2
M-CSA help_outline
Structural and functional characterization of human microsomal prostaglandin E synthase-1 by computational modeling and site-directed mutagenesis.
Huang X., Yan W., Gao D., Tong M., Tai H.H., Zhan C.G.
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) has recently been recognized as a novel, promising drug target for inflammation-related diseases. Functional and pathological studies on this enzyme further stimulate to understand its structure and the structure-function relationships. Using an ... >> More
Microsomal prostaglandin (PG) E synthase-1 (mPGES-1) has recently been recognized as a novel, promising drug target for inflammation-related diseases. Functional and pathological studies on this enzyme further stimulate to understand its structure and the structure-function relationships. Using an approach of the combined structure prediction, molecular docking, site-directed mutagenesis, and enzymatic activity assay, we have developed the first three-dimensional (3D) model of the substrate-binding domain (SBD) of mPGES-1 and its binding with substrates prostaglandin H2 (PGH2) and glutathione (GSH). In light of the 3D model, key amino acid residues have been identified for the substrate binding and the obtained experimental activity data have confirmed the computationally determined substrate-enzyme binding mode. Both the computational and experimental results show that Y130 plays a vital role in the binding with PGH2 and, probably, in the catalytic reaction process. R110 and T114 interact intensively with the carboxyl tail of PGH2, whereas Q36 and Q134 only enhance the PGH2-binding affinity. The modeled binding structure indicates that substrate PGH2 interacts with GSH through hydrogen binding between the peroxy group of PGH2 and the -SH group of GSH. The -SH group of GSH is expected to attack the peroxy group of PGH2, initializing the catalytic reaction transforming PGH2 to prostaglandin E2 (PGE2). The overall agreement between the calculated and experimental results demonstrates that the predicted 3D model could be valuable in future rational design of potent inhibitors of mPGES-1 as the next-generation inflammation-related therapeutic. << Less
Bioorg. Med. Chem. 14:3553-3562(2006) [PubMed] [EuropePMC]
Essential 110Cys in active site of membrane-associated prostaglandin E synthase-2.
Watanabe K., Ohkubo H., Niwa H., Tanikawa N., Koda N., Ito S., Ohmiya Y.
The amino acid sequence of membrane-associated prostaglandin (PG) E synthase-2 (mPGE synthase-2), which has a broad specificity in its thiol requirement for a catalytic activity, has the consensus region from 104Leu to 120Leu found in glutaredoxin and of thioredoxin. The sequence of Cys-x-x-Cys in ... >> More
The amino acid sequence of membrane-associated prostaglandin (PG) E synthase-2 (mPGE synthase-2), which has a broad specificity in its thiol requirement for a catalytic activity, has the consensus region from 104Leu to 120Leu found in glutaredoxin and of thioredoxin. The sequence of Cys-x-x-Cys in the consensus region is the active site for thioredoxin and mPGE synthase-2 also has this amino acid sequence (110Cys-x-x-113Cys). The mutation from 110Cys to Ser or the double mutation from 110Cys and 113Cys to Ser caused loss of PGE synthase activity, whereas the single mutation from 113Cys to Ser did not affect the enzyme activity. These results indicate that 110Cys, but not 113Cys, is the essential amino acid in the active site of mPGE synthase-2. 110Cys is an important amino acid in PGE synthase activity and plays the critical role as Cys at the same position in redoxin. Moreover, we found that the reduced form of lipoic acid (dihydrolipoic acid) serves as one of the natural activators of mPGE synthase-2 in the cells. << Less
Biochem. Biophys. Res. Commun. 306:577-581(2003) [PubMed] [EuropePMC]
Identification and characterization of a novel type of membrane-associated prostaglandin E synthase.
Tanikawa N., Ohmiya Y., Ohkubo H., Hashimoto K., Kangawa K., Kojima M., Ito S., Watanabe K.
Membrane-associated prostaglandin E synthase (mPGE synthase) was previously purified to apparent homogeneity from the microsomal fraction of bovine heart (Watanabe, K., et al., Biochim. Biophys. Acta 1439, 406--414, 1999). The N-terminal 22-amino acid sequence of the purified enzyme was identical ... >> More
Membrane-associated prostaglandin E synthase (mPGE synthase) was previously purified to apparent homogeneity from the microsomal fraction of bovine heart (Watanabe, K., et al., Biochim. Biophys. Acta 1439, 406--414, 1999). The N-terminal 22-amino acid sequence of the purified enzyme was identical to that of the 88th to 109th amino acids deduced from the monkey (AB046026) or human (AK024100) cDNA that encodes a hypothetical protein with unknown function. The primary structure has the consensus region of glutaredoxin and of thioredoxin. We constructed an expression plasmid, using the vector (pTrc-HisA) and the monkey cDNA for the 290-amino-acid polypeptide. The recombinant protein with a M(r) of 33 kDa exhibited PGE synthase activity and was purified to apparent homogeneity by nickel-chelating column chromatography. The V(max) and K(m) values for PGH(2) of the purified recombinant mPGE synthase were about 3.3 mumol/min center dot mg of protein and 28 muM, respectively. The recombinant enzyme was activated by various SH-reducing reagents, i.e., dithiothreitol, glutathione (GSH), and beta-mercaptoethanol, in order of decreasing effectiveness. Moreover, the mRNA distribution was high in the heart and brain, but the mRNA was not expressed in the seminal vesicles. These results indicate that the recombinant mPGE synthase is identical to the enzyme purified from the microsomal fraction of bovine heart, and is a novel type of mPGE synthase based on the primary structure, a broad specificity of thiol requirement, and tissue distribution. << Less
Purification and characterization of membrane-bound prostaglandin E synthase from bovine heart.
Watanabe K., Kurihara K., Suzuki T.
Prostaglandin (PG) E synthase was solubilized with 6 mM sodium deoxycholate from the microsomal fraction of bovine hearts. The enzyme was purified by about 800-fold to apparent homogeneity. The specific activity of the purified enzyme was about 830 mU/mg of protein, and the K(m) value for PGH(2) w ... >> More
Prostaglandin (PG) E synthase was solubilized with 6 mM sodium deoxycholate from the microsomal fraction of bovine hearts. The enzyme was purified by about 800-fold to apparent homogeneity. The specific activity of the purified enzyme was about 830 mU/mg of protein, and the K(m) value for PGH(2) was 24 microM. The molecular weight of the enzyme was about 31000 on SDS-polyacrylamide gel electrophoresis and was about 60000 by gel filtration. The enzyme was separated from glutathione (GSH) S-transferase by DEAE-Toyopearl column chromatography, and did not exhibit any GSH S-transferase activity towards four different substrates. The purified enzyme was active in the absence of GSH, but it was activated by various SH-reducing reagents including dithiothreitol, GSH, or beta-mercaptoethanol. This is the first reported purification of membrane-bound PGE synthase to apparent homogeneity. << Less
Biochim. Biophys. Acta 1439:406-414(1999) [PubMed] [EuropePMC]
Identification of human prostaglandin E synthase: a microsomal, glutathione-dependent, inducible enzyme, constituting a potential novel drug target.
Jakobsson P.-J., Thoren S., Morgenstern R., Samuelsson B.
Human prostaglandin (PG) E synthase (EC 5.3.99.3) is a member of a recently recognized protein superfamily consisting of membrane associated proteins involved in eicosanoid and glutathione metabolism (the MAPEG family). Previous designations of the protein are PIG12 and MGST1-L1. PGE synthase was ... >> More
Human prostaglandin (PG) E synthase (EC 5.3.99.3) is a member of a recently recognized protein superfamily consisting of membrane associated proteins involved in eicosanoid and glutathione metabolism (the MAPEG family). Previous designations of the protein are PIG12 and MGST1-L1. PGE synthase was expressed in Escherichia coli, and both cytosolic and membrane fractions were prepared. Western blot analysis specifically detected a 15-to 16-kDa protein in the membrane fraction. Both fractions were incubated with prostaglandin H2 in the presence or absence of reduced glutathione. The membrane but not the cytosolic fraction was found to possess high glutathione-dependent PGE synthase activity (0.25 micromol/min/mg). The human tissue distribution was analyzed by Northern blot analysis. High expression of PGE synthase mRNA was detected in A549 and HeLa cancer cell lines. Intermediate level of expression was demonstrated in placenta, prostate, testis, mammary gland, and bladder whereas low mRNA expression was observed in several other tissues. A549 cells have been used as a model system to study cyclooxygenase-2 induction by IL-1beta. If A549 cells were grown in the presence of IL-1beta, a significant induction of the PGE synthase was observed by Western blot analysis. Also, Western blot analysis specifically detected a 16-kDa protein in sheep seminal vesicles. In summary, we have identified a human membrane bound PGE synthase. The enzyme activity is glutathione-dependent, and the protein expression is induced by the proinflammatory cytokine IL-1beta. PGE synthase is a potential novel target for drug development. << Less
Proc. Natl. Acad. Sci. U.S.A. 96:7220-7225(1999) [PubMed] [EuropePMC]
Molecular identification of cytosolic prostaglandin E2 synthase that is functionally coupled with cyclooxygenase-1 in immediate prostaglandin E2 biosynthesis.
Tanioka T., Nakatani Y., Semmyo N., Murakami M., Kudo I.
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE(2) biosynthetic pathway. GSH-dependent PGES activity in the cytosol of rat brains, but not of other tissues, i ... >> More
Here we report the molecular identification of cytosolic glutathione (GSH)-dependent prostaglandin (PG) E(2) synthase (cPGES), a terminal enzyme of the cyclooxygenase (COX)-1-mediated PGE(2) biosynthetic pathway. GSH-dependent PGES activity in the cytosol of rat brains, but not of other tissues, increased 3-fold after lipopolysaccharide (LPS) challenge. Peptide microsequencing of purified enzyme revealed that it was identical to p23, which is reportedly the weakly bound component of the steroid hormone receptor/hsp90 complex. Recombinant p23 expressed in Escherichia coli and 293 cells exhibited all the features of PGES activity detected in rat brain cytosol. A tyrosine residue near the N terminus (Tyr(9)), which is known to be critical for the activity of cytosolic GSH S-transferases, was essential for PGES activity. The expression of cPGES/p23 was constitutive and was unaltered by proinflammatory stimuli in various cells and tissues, except that it was increased significantly in rat brain after LPS treatment. cPGES/p23 was functionally linked with COX-1 in marked preference to COX-2 to produce PGE(2) from exogenous and endogenous arachidonic acid, the latter being supplied by cytosolic phospholipase A(2) in the immediate response. Thus, functional coupling between COX-1 and cPGES/p23 may contribute to production of the PGE(2) that plays a role in maintenance of tissue homeostasis. << Less
J. Biol. Chem. 275:32775-32782(2000) [PubMed] [EuropePMC]
Purification and characterization of recombinant microsomal prostaglandin E synthase-1.
Ouellet M., Falgueyret J.-P., Ear P.H., Pen A., Mancini J.A., Riendeau D., Percival M.D.
Recombinant human microsomal prostaglandin E(2) synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell membranes with diheptanoylphosphatidylcholine and purified in the presence of octylglucoside using hydroxyapatite column chromatography. Th ... >> More
Recombinant human microsomal prostaglandin E(2) synthase-1 (mPGES-1) was expressed in a baculovirus-Sf9 cell system. The mPGES-1 was solubilized from Sf9 cell membranes with diheptanoylphosphatidylcholine and purified in the presence of octylglucoside using hydroxyapatite column chromatography. The K(m) values of the substrates PGH(2) and GSH were 14 microM and 0.75 mM, respectively, with the purified enzyme. The specific activity (4 micromol/min/mg) was increased 3-5-fold by non-ionic and zwitterionic detergents. Kinetic analysis showed that dodecylmaltoside increases V(max) but does not affect the K(m) values of either substrate. Several other thiol-containing compounds were tested as glutathione replacements, none of which yielded detectable enzyme activity. During enzyme catalysis, glutathione was not oxidized and therefore can be considered an enzyme cofactor. No glutathione transferase or peroxidase activity could be determined with a range of potential substrates. The results show that purified mPGES-1 has a specific activity similar to Cox-2, consistent with its postulated role in Cox-2 mediated PGE(2) formation. << Less
Protein Expr. Purif. 26:489-495(2002) [PubMed] [EuropePMC]
Studies on membrane-associated prostaglandin E synthase-2 with reference to production of 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT).
Watanabe K., Ito S., Yamamoto S.
Membrane-associated prostaglandin (PG) E synthase (mPGE synthase)-2 catalyzes the conversion of PGH(2) primarily to PGE(2). The enzyme is activated by various sulfhydryl reagents including dithiothreitol, dihydrolipoic acid, and glutathione, and it is different from mPGE synthase-1 and cytosolic P ... >> More
Membrane-associated prostaglandin (PG) E synthase (mPGE synthase)-2 catalyzes the conversion of PGH(2) primarily to PGE(2). The enzyme is activated by various sulfhydryl reagents including dithiothreitol, dihydrolipoic acid, and glutathione, and it is different from mPGE synthase-1 and cytosolic PGE synthase, both of which require specifically glutathione. Recently, other investigators reported that their preparation of mPGE synthase-2 containing heme converted PGH(2) to 12L-hydroxy-5,8,10-heptadecatrienoic acid (HHT) rather than to PGE(2) [T. Yamada, F. Takusagawa, Biochemistry 46 (2007) 8414-8424]. As we examined presently, the heme-bound enzyme expressed and purified according to their method synthesized HHT from PGH(2), but also PGE(2) in a decreased amount. Whereas the PGE synthase activity was completely lost at 50 degrees C for 5 min, the HHT synthase activity remained even at 100 degrees C for 5 min. In contrast, when the heme-bound enzyme was purified in the presence of dithiothreitol, only PGE(2) was produced, but essentially no HHT was detected. Thus, native mPGE synthase-2 enzymatically catalyzes only the conversion of PGH(2) to PGE(2), but not to HHT, and heme is not involved in this reaction. << Less
Metabolism of the endocannabinoids, 2-arachidonylglycerol and anandamide, into prostaglandin, thromboxane, and prostacyclin glycerol esters and ethanolamides.
Kozak K.R., Crews B.C., Morrow J.D., Wang L.H., Ma Y.H., Weinander R., Jakobsson P.J., Marnett L.J.
Cyclooxygenase-2 (COX-2) action on the endocannabinoids, 2-arachidonylglycerol (2-AG) and anandamide (AEA), generates prostaglandin glycerol esters (PG-G) and ethanolamides (PG-EA), respectively. The diversity of PG-Gs and PG-EAs that can be formed enzymatically following COX-2 oxygenation of endo ... >> More
Cyclooxygenase-2 (COX-2) action on the endocannabinoids, 2-arachidonylglycerol (2-AG) and anandamide (AEA), generates prostaglandin glycerol esters (PG-G) and ethanolamides (PG-EA), respectively. The diversity of PG-Gs and PG-EAs that can be formed enzymatically following COX-2 oxygenation of endocannabinoids was examined in cellular and subcellular systems. In cellular systems, glycerol esters and ethanolamides of PGE(2), PGD(2), and PGF(2alpha) were major products of the endocannabinoid-derived COX-2 products, PGH(2)-G and PGH(2)-EA. The sequential action of purified COX-2 and thromboxane synthase on AEA and 2-AG provided thromboxane A(2) ethanolamide and glycerol ester, respectively. Similarly, bovine prostacyclin synthase catalyzed the isomerization of the intermediate endoperoxides, PGH(2)-G and PGH(2)-EA, to the corresponding prostacyclin derivatives. Quantification of the efficiency of prostaglandin and thromboxane synthase-directed endoperoxide isomerization demonstrated that PGE, PGD, and PGI synthases catalyze the isomerization of PGH(2)-G at rates approaching those observed with PGH(2). In contrast, thromboxane synthase was far more efficient at catalyzing PGH(2) isomerization than at catalyzing the isomerization of PGH(2)-G. These results define the in vitro diversity of endocannabinoid-derived prostanoids and will permit focused investigations into their production and potential biological actions in vivo. << Less
This publication is cited by 7 other entries.
Human microsomal prostaglandin E synthase-1: purification, functional characterization, and projection structure determination.
Thoren S., Weinander R., Saha S., Jegerschold C., Pettersson P.L., Samuelsson B., Hebert H., Hamberg M., Morgenstern R., Jakobsson P.-J.
Human, microsomal, and glutathione-dependent prostaglandin (PG) E synthase-1 (mPGES-1) was expressed with a histidine tag in Escherichia coli. mPGES-1 was purified to apparent homogeneity from Triton X-100-solubilized bacterial extracts by a combination of hydroxyapatite and immobilized metal affi ... >> More
Human, microsomal, and glutathione-dependent prostaglandin (PG) E synthase-1 (mPGES-1) was expressed with a histidine tag in Escherichia coli. mPGES-1 was purified to apparent homogeneity from Triton X-100-solubilized bacterial extracts by a combination of hydroxyapatite and immobilized metal affinity chromatography. The purified enzyme displayed rapid glutathione-dependent conversion of PGH2 to PGE2 (Vmax; 170 micromol min-1 mg-1) and high kcat/Km (310 mm-1 s-1). Purified mPGES-1 also catalyzed glutathione-dependent conversion of PGG2 to 15-hydroperoxy-PGE2 (Vmax; 250 micromol min-1 mg-1). The formation of 15-hydroperoxy-PGE2 represents an alternative pathway for the synthesis of PGE2, which requires further investigation. Purified mPGES-1 also catalyzed glutathione-dependent peroxidase activity toward cumene hydroperoxide (0.17 micromol min-1 mg-1), 5-hydroperoxyeicosatetraenoic acid (0.043 micromol min-1 mg-1), and 15-hydroperoxy-PGE2 (0.04 micromol min-1 mg-1). In addition, purified mPGES-1 catalyzed slow but significant conjugation of 1-chloro-2,4-dinitrobenzene to glutathione (0.8 micromol min-1 mg-1). These activities likely represent the evolutionary relationship to microsomal glutathione transferases. Two-dimensional crystals of purified mPGES-1 were prepared, and the projection map determined by electron crystallography demonstrated that microsomal PGES-1 constitutes a trimer in the crystal, i.e. an organization similar to the microsomal glutathione transferase 1. Hydrodynamic studies of the mPGES-1-Triton X-100 complex demonstrated a sedimentation coefficient of 4.1 S, a partial specific volume of 0.891 cm3/g, and a Stokes radius of 5.09 nm corresponding to a calculated molecular weight of 215,000. This molecular weight, including bound Triton X-100 (2.8 g/g protein), is fully consistent with a trimeric organization of mPGES-1. << Less
This publication is cited by 1 other entry.
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text:
Electrophaes niveopicta är en fjärilsart som beskrevs av W. Warren 1893. Electrophaes niveopicta ingår i släktet Electrophaes och familjen mätare. Inga underarter finns listade i Catalogue of Life.

Källor

Mätare
niveopicta

redpajama_set_name: RedPajamaWikipedia


text:
The Environmental Voter Project's Fall Fundraiser
On Wednesday, Sept. 22nd, 6 – 6:30 pm ET the Environmental Voter Project (EVP), a non-partisan nonprofit group, will host a 30-minute Zoom call that will include special guest speakers, volunteer testimonials, and fresh voter turnout data. There will also be optional networking sessions prior to the event, and an optional Q&A after the event. If you want a way to help save the planet, the EVP is a worthy cause. EVP finds environmentalists who don't vote and then mobilizes them for local, state, and federal elections. They do not endorse candidates – they focus on voters, not politicians. In recent years they have reached over 100 million people with digital ads, sent text messages to over 10 million people, called more than 5 million voters.
EVP's primary goal is to change the electorate over time, building an unstoppable army of environmental voters. Each year, they track how many seldom-voting and non-voting environmentalists they have helped convert into consistent super voters who now reliably vote in federal, state, and local elections. They have created almost three-quarters of a million super voters in the last five years.
Their efforts are born out of a new empirical approach to politics and activism. Their model is based on scientifically rigorous research and that same precision and accountability is applied to their internal operations. EVP doesn't try to convince people to care more about the environment. Instead, they find already convinced environmentalists who don't vote, and then they turn them into better voters. EVP uses every election – local, state, and federal – as a behavioral intervention opportunity for turning non-voters into super voters.
In 2020 EVP was active in the presidential primaries targeting 4 million environmentalists who were unlikely to vote in their presidential primaries and caucuses. They were active in hundreds of local elections helping to nudge first-time voters into becoming habitual voters. In low-turnout state primaries, they familiarized millions of environmentalists with new vote-by-mail and early voting procedures. In the general election, they engaged over 1.8 million never voted-before environmentalists with previously tested and optimized messaging over texts, calls, digital ads, and direct mail. In the Georgia special election, they mobilized 380,000 unlikely voters.
Just as they learn from others, they are also committed to sharing our knowledge with other environmental groups and the broader academic community. In 2020, EVP staff-led trainings for over a dozen environmental organizations, and our Executive Director gave guest lectures at Harvard University, Yale University, MIT, Dartmouth College, Cornell University, and Tufts University.
EVP is the only environmental organization that will be active in hundreds of local elections in 2021, leveraging big data, behavioral science, and thousands of well-trained volunteers to take advantage of the long-term electorate-building opportunities offered by these under-the-radar elections.
A-Zoom attendance link will be provided in the confirmation email after you RSVP below. All donation amounts are welcome and appreciated.
For more information about the EVP click here.
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Science Education – Environmental and Sustainability Conferences
Are the Gulf and Jet Streams Collapsing? Here's what the Science Says
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VERGE 21 Online Event will take place October 25-29, 2021. The VERGE Carbon conference focuses on unlocking the value of carbon pollution by using it to create innovative products, materials,...
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Just as Congress was showing signs that it might, after 16 years, start to rein in the nation's growing list of post-9/11 wars, the Trump administration told Congress no thanks, we are happy with the overbroad authorities we've got.
In a letter to Chairman of the Senate Foreign Relations Committee, Bob Corker (R-TN), the State Department's Bureau of Legislative Affairs wrote, "the Administration is not seeking revisions to the 2001 AUMF or additional authorizations to use force." The letter was released just before Secretary of State Rex Tillerson and Secretary of Defense Jim Mattis were scheduled to testify behind closed doors on the administration's views on authorizations for use of military force.
What's different in this letter is the claim that both the domestic and legal bases cited also include the authority to use force against the Syrian government and pro-Assad forces to the extent such force is a necessary and proportionate measure "to defend U.S., Coalition, or partner forces engaged in the campaign against ISIS." The significant extension here is two-fold: (1) the claimed authority to engage in hostilities against forces other than AQ and ISIS and their associated forces, including State armed forces like Syria and forces supporting them; and (2) the claimed authority to use force in defense of partner forces, presumably including non-state actors like the Syrian Democratic Forces. These claims raise a host of legal, policy, and national security issues—several of which are discussed in detail by Adil Haque here, Ryan Goodman here, and Steve Vladeck and Bobby Chesney here.
Of particular significance going forward is the impact of this letter on the AUMF debate in Congress. It's clear from today's letter that the administration prefers the status quo, which requires a nexus to the 9/11 attackers but otherwise has no time limits, no geographic limits, no congressional or public reporting requirements, and has been interpreted to allow the executive branch—not Congress—to make the decision to go to war with new terrorist groups as long as they meet the administration's own definition of "associated forces" or offshoots of al Qaeda or the Taliban. Senator Corker said that he plans to hold a hearing on the Kaine-Flake AUMF proposal regardless of the outcome of today's closed hearing, but today's development raises the question of whether Congress will finally assert its constitutional prerogatives over war or use the administration's comfort with the status quo as justification for shirking its responsibility.


When most folks hear the word, "Tuscany" many things come to mind, olive oil, wines and great culinary treasures, and of course for many "romance" figures nicely into the equation. A thought which has no doubt been perpetuated and punctuated by this region's rich history, endless rolling hills, its many cypress-lined country roads and a language chock full romantic ideas and notions.
For me, I immediately think of all the great wines produced in this fabulous region, which has so much to offer the wandering wino and even the garden variety vino-sapien thirsting for wines that burst with layers of flavor and structure, wines that compliment your meal, instead of getting in the way.
To me wines from this region represent idea in wine that far too many folks look past these days, that don't say, "hey, look at me". It was funny a question was posited the other day, "what region would you choose, if it was the only region you were allowed to drink from", I didn't even hesitate for a second, I immediately answered Montalcino, my favorite region in Tuscany, hello Brunello.
For those looking for a fruit forward, sappy, soulless California style of wine, sorry to say, "forget about it". For the rest of you looking for an earthy, though mouth watering Tuscan gem meant to go with a great meal; this is your ticket to ride.
After a swirl and fat slurp, wow a boat-load of layered complexity. The bouquet is fascinating and deep with focused blackberry and dark cherry notes, enriched by leather, sweet oak, tobacco, a hint of chocolate and coffee scents. The mineral character comes through nicely with sensation of rich earth flavors. This full-bodied wine shows a wonderful core of ripe fruit right up front, a silky mouth feel and a soft texture with a notable length.
For those of you not familiar with Ciliegiolo; [I wasn't] it's a red wine grape variety normally found in central and north-western Italy. Frankly, it's something of an obscurity, but with over 800 different grapes, not a surprise. Until recently is has been said to be, "undergoing something of a renaissance in Liguria and in the heart of Tuscany." And according to my WSET book, "the grape's name comes from an Italian word for 'cherry', a fruit which Ciliegiolo wines resemble both in color and aroma".
This is the type of wine in my opinion that is surely poised for unique harmony with many varied food pairing opportunities. Look for this wine to compliment your next meal; as they say in Italy, wine should be non impegnativo, meaning it should not demand too much attention.
If it were me, I'd suggest maybe going with something like organic pasta of your choice; smother it in Italian sausage, cooked-down fresh garden tomatoes and sautéed mushrooms. Another great choice for something off-the-grill; lamb shanks with fresh herbs or if you prefer to go the meatless route, I'd go with mozzarella stuffed Portobello's. Getting hungry and thirsty yet? I know I am just thinking about it. By the way, Steven Tanzer gave this wine 90 points and it sells for average SRP of $16, I secured this bottle from my friends at The 3rd Corner. I really liked this wine and gave it score of 88 points, it's a best buy.
Sassotondo Ciliegiolo is a favorite of mine. Some restaurant in North Beach had it by the glass when I was visiting SF back in 2005, but I couldn't find it in retail. Fortunately, I visited Pitigliano in 2006 and met the woman who makes it, and then bought 6 bottles back with me when I visited Rome in 2009. (No one has ever more joyfully carried a half-case of wine on public transportation!) Around Pitigliano, it's served with wild boar ragu--delicious. I'm thrilled to hear that it's available in retail now, because my remaining four bottles of 2005 seem too dear to drink!
Ha Gilanah, that sounds like a great story. I was really impressed with this wine and can't wait to get more myself. oh-my, I really fell in love with wild boar ragu myself during my first trip to Tuscany, just can't seem to find it here in San Diego.
Those 05's must be drinking fab, right now, Ciliegiolo is a fantastic wine-bearing grape, here's to the wine-glass staying half-full, cheers!


text:
Column: As first lady, Melania Trump always stood by her man
Katie Ledecky chasing swimming legends
By Philip Hersh
Katie Ledecky (L) smiles after beating MIssy Franklin (R) in the 200 freestyle final at the U.S. Championships. (Robert Hanashiro / USA Today Sports)
IRVINE, Calif. — The superficial story line emerging from the U.S. Swimming Championships has been the rivalry between teenage frenemies Missy Franklin, 19, and Katie Ledecky, 17, but the top two women swimmers in the world really compete against each other only in a single event.
A little deeper dive reveals Ledecky actually is racing past greats like Shane Gould of Australia and Shirley Babashoff of the United States, swimmers able to cover an all-encompassing range of freestyle events at an extraordinarily high level.
"The standard is Shane Gould," said Ledecky's coach, Bruce Gemmell. "And that standard is pretty high."
Gould, only 16 when she retired a year after the 1972 Olympics, once held world records in the 100, 200, 400, 800 and 1,500-meter freestyles and the 200 individual medley. In those Munich Summer Games, she won gold medals in the 200 and 400 free and 200 IM, a silver in the 800 free and bronze in the 100.
In two Olympics, Babashoff won silver medals in the 100, 200, 400 and 800 freestyles and swam a leg on the two winning 400-meter free relays.
Ledecky, a rising high school senior in Bethesda, Md., who has committed to Stanford, is reigning Olympic champion in the 800 freestyle, reigning world champion in the 400, 800 and 1,500 and world record-holder in the longest two.
Thursday, she extended her championship range a bit further when she beat Franklin in the 200 freestyle with personal best times in the heats and final. The latter, 1 minute, 55.16 seconds, ranks second in the world this season.
A year ago at nationals, they were 1-2 in the opposite order.
"I was trying to think earlier how many times I actually have had to race (Missy), and it's probably just a handful," Ledecky said. "It's always an honor to be in a heat with her and always a lot of fun and great racing."
Such appreciation is mutual. Franklin said earlier this week of Ledecky, "Her accomplishments over the past two years have been unreal." Ledecky, named swimmer of the meet at the 2013 world championships for her three individual and one relay gold medals, said at the time Franklin deserved the award for her world meet women's record of three individual and three relay golds.
[Most read] My worst moment: Kyra Sedgwick, with lots and LOTS of police and a wild movie night at Tom Cruise's house »
Ledecky could be treading on more of Franklin's water soon.
She swam the 100 freestyle heats Wednesday in 54.96, a .26 improvement on her personal best that was 13th fastest in the qualifying. Ledecky chose not to swim the B final of that event, saving energy she barely needed for the 800 final, so easy was her victory. Franklin won the 100 title in 53.43.
"It was pretty clear when I first started working with her she had more speed than a lot of distance swimmers," Gemmell said. "And she expressed a lot of interest in swimming on relays (where 200 is the top distance). Those two factors make a good combination to get more speed."
Gemmell trains Ledecky most for the 400 free, the event she swims Saturday. He finds it more valuable to have her workouts contain eight 100 repeats than a single 800.
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"I just like the feeling of a hard practice, and Bruce gives them to us," Ledecky said. "I see myself more as a freestyler than a distance swimmer.''
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Ledecky has the seemingly perfect demeanor for a distance swimmer, whose events are an exercise akin to singing, "Ninety-nine bottles of beer on the wall." She is dead serious in workouts and takes a stone face to the starting blocks.
"Quiet like an assassin," Gemmell said.
Ledecky, then 15, was the most surprising women's winner at the London Olympics. Equally stunning were the June swims that broke her own world records in the 800 and 1,500 with no competition at a low-key Texas invitational meet, immediately after finishing 18 days of intense training in Colorado Springs, Colo., her introduction to altitude training.
A college coach who watched one of Ledecky's workouts told Gemmell, "She loves to chase the boys, doesn't she." Said Gemmell: "She loves to race."
And do it fast enough to dominate the present and chase the past.
Missy Franklin
QB Ryan Hilinski says he's transferring to Northwestern from South Carolina, where he started as a freshman in 2019
Don Sutton, the Hall of Fame Los Angeles Dodgers pitcher, dies at 75


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Delaware Leaders in Economic Development: Patty Cannon
May 12, 2021 –
Patty Cannon, Director of Intergovernmental Relations & Special Projects, Delaware Division of Small Business
Patty Cannon has been the director of Intergovernmental Relations & Special Projects with the Delaware Division of Small Business since 2015. She and her colleagues partner with Delaware business and industry leaders and state, county and municipal representatives – and collaborate with site selectors, consultants, real estate brokers, sister agencies and community groups – to grow Delaware's economy.
Cannon's work centers around initiatives such as Brownfields development and redevelopment; statewide comprehensive economic development strategies; EB-5 targeted employment areas; the Emission Reduction Credit Program and Foreign Trade Zone administration. She finds her work in economic development truly gratifying, thanks to its ability to change lives.
"It is tremendously satisfying to know that your efforts to recruit and/or retain a business can have such a positive impact in your community," she says. "Always remember that every piece of the puzzle matters!"
What attracts you to the field of economic development?
Economic development happens when passionate people who care about a community find creative and collaborative ways to meet the needs of industry leaders. I have always been attracted to working with people who may approach a problem from very different perspectives but who have a shared goal of finding mutually rewarding solutions. At its core, economic development is about listening to truly learn the needs of the community and the business leaders and then working to find a way to meet those needs that is compatible to both sides. Headlines often promote economic wins as though a company made a decision, but in reality, PEOPLE are making decisions, respectively, about what is best for their community and their business. I thoroughly enjoy being in the "people" business.
What advice would you give someone considering a career in economic development?
A career in economic development is exciting and rewarding! When a company's leadership chooses to create jobs in your community, it has a positive impact that enriches the entire community. Some of your friends and neighbors may find a new career, local businesses may become suppliers to the new business and, often, new capital investments will create new construction jobs. Whether your contributions are focused on data collection, writing narrative, negotiating incentives, refining site selection, creative compilation or permitting, never underestimate how important each piece of that puzzle matters to presenting the best business proposition for the business leaders who will be making the final decisions.
What do you see as Delaware's unique selling proposition?
Delaware is often referred to as a "state of neighbors," and that is Delaware's strongest and most unique selling proposition! Delaware boasts all of the traditional economic development assets, including a highly skilled workforce, customized training opportunities, expedited permitting, etc. But the collegial approach to neighbors helping neighbors is the magic that is the "Best of Delaware" – in my humble opinion. From elected officials and regulators working across the aisle, to industry, labor and community leaders working together, Delaware is a "state of neighbors," and we welcome you to visit Delaware. This unique "selling proposition" is best experienced in person!
What is the latest book you have read and would recommend?
"Riding the Bus with My Sister" by Rachel Simon (a Delaware author). It's a gentle reminder that everyone has value and deserves to find their place in this world.
What have been some highlights of your career to date?
One of the greatest highlights of my career to date was in leading Delaware's response to the famous Amazon HQ2 RFP. As you may recall, Delaware did not land the Amazon headquarters, but we did, in fact, build an amazing team of community leaders who worked together to craft a compelling business case. Amazon's debriefing taught us that although there were other locations with larger population density that pushed Delaware out of the top contenders for that project, Delaware had submitted an impressive response that got their attention.
The Amazon HQ2 team members have continued to contribute to Delaware's economic development efforts in various ways. Just to name a few: Ben duPont, who was a founding member of Zip Code Wilmington, continues to develop creative ways to grow Delaware's coding expertise through Zip Code Wilmington, the {OpenBracket Delaware} computer coding championship and as managing director and co-founder of Chartline Capital Partners; Patrick Callahan, a serial entrepreneur, has developed a team to launch the Delaware Data Innovation Lab; and, John Riley published his first book, "Delaware Eyewitness: Behind the Scenes in the First State," after leading government relations for two global corporations and helping to set up Delaware Prosperity Partnership to lead Delaware's economic development initiatives into the future.


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Guide to Jewish Life
Regional Chapter of the Year
Erin Clare
I am president of the Beth Israel chapter of United Synagogue Youth, which recently was named Seaboard USY's 2013 Chapter of the Year. As much as my ego would love for me to take credit for this, it really has been a work in progress at Beth Israel for the past six years.
Many people have been involved, and it is through everyone's hard work that we earned this cherished award. Two years ago, after we were named Most Improved Chapter, we asked ourselves, "Why can't we be Chapter of the Year?"
At our first 2012-13 board meeting, we were asked to write down our goals. I wrote: Win Chapter of the Year. All of us decided that to reach our goals, we would have to fill our calendar with bigger, better and more exciting events that would help us stand out in the region.
These events included an Israeli-themed cake night where we created two unique four-foot maps of Israel and a Hanukah-themed "Iron Chef"-style cook-off. We were also able to expand on our yearly Mystery Bus Ride with help from a Blaustein grant, not only drawing more local teens, but also traveling by bus to Rebounderz, an indoor trampoline arena in Sterling, Va. We held a huge scavenger hunt at a Wal-Mart for the children at Kennedy Krieger. And we even went curling. We had more people at these events than ever before.
In addition, we increased the money raised for the USY Tikun Olam Fund; we raised more than $800. We also collected toys for donation to local organizations and we did this through a bake sale, a Purim dance competition and an auction.
Fast-forward to the Spring Convention this past May. On a Saturday night, the 12 participants from Beth Israel sat together during the awards ceremony. There we were, all holding hands, and my heart was beating so fast and loud that I almost didn't hear the announcement. We had been named Chapter of the Year by the Seaboard Region USY. I had never been so proud of our members.
To everyone who has been involved with Beth Israel Youth in the past few years, I want to thank you. I just happened to be president when we reached our goal. The dedication, determination and hard work by past board members, our youth director and USY advisers has been inspiring. All of us together accomplished this milestone.
We wish to invite all local Jewish high school students to join us at our kickoff event on Sept. 21, a rocking karaoke dance party in the Beth Israel sukkah. More information will be posted on our Facebook page, Beth Israel USY Official Group, in Aug-ust. You don't need to be a member to attend, but you'll want to be one once you see why we were named Chapter of the Year.
For more information, email biomusy@bethisrael-om.org.
Josh Rosenbaum is a rising senior at Franklin High School and is starting his second term as Beth Israel USY's president.
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A scientist was eaten alive by a 17ft long crocodile after being dragged into its enclosure while she fed it.
Deasy Tuwo, 44, was giving the crocodile, named Merry, lumps of meat last Friday morning in North Sulawesi, Indonesia.
But the beast stood on its hind legs and leaped an 8ft high concrete wall to pull the researcher into the shallow water.
made the grim discovery at around 8.45am when they noticed a "strange shape" in the water.
They then saw the crocodile laying on the ground with Deasy's savaged body in its jaws.
The reptile had ripped off Deasy's left arm and mutilated her upper torso.
Rescue workers battled to retrieve Deasy's body from the croc, which thrashed violently every time they tried to approach it.
Friends describe Deasy as a "quiet person" who loved animals.
Former Colleague Merry Supit said: "She was the head of the lab. A quiet person. We're confused about how this has happened.
Deasy's colleague Erling Rumengan said: "We were curious when we looked at the crocodile pool, there was a floating object, it was Deasy's body.
"We were afraid to touch it and we immediately reported the incident at the Tombariri police station.


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WIRED on Energy
The UK's complex network of tiny airports is ideal for electric planes
Big aviation firms are supporting the development of electric planes. When they arrive, they'll be ideal for shorter, regional flights
Sunday 5 August 2018
Zunum Aero
The aviation industry has high hopes for electric planes. Last year, 859 million tonnes of carbon dioxide (CO2) was produced by flights. This accounts for around two per cent of all human-created carbon emissions and aviation is responsible for 12 per cent of all transport-produced CO2.
The majority of CO2 produced by planes – around 80 per cent, according to the Air Transport Action Group's figures – comes from flights that are longer than 1,500 kilometres. Unless there's a radical overhaul of the aviation industry, there are few ways to drastically reduce the CO2 emitted by long-haul flights.
But shorter flights are in prime position for a CO2 emissions cut. Enter electric planes. Airbus, Rolls-Royce, and Boeing are all involved in the development of prototype electric and hybrid electric planes and both the airliners EasyJet and JetBlue are supporting the creation of the new aircraft.
Not only could electric planes reduce carbon emissions from flights, they also promise to reduce noise pollution, says Frank Anton, the head of electric aircraft at Siemens. The company is working with Airbus and Rolls-Royce to develop a hybrid-electric plane – involving both electric motors and batteries. "There are enough reasons to change the architecture of a plane towards distributed electric propulsion and using hybrid electric," Anton explains. Startups Zunum Aero, Wright Electric and Eviation are all developing their own electric planes.
The spiralling environmental cost of our lithium battery addiction
By Amit Katwala
Depending on the type of plane developed – it's size, weight, and the number of passengers it can carry – Anton predicts it is possible to reduce fuel consumption by 25 per cent. He says hybrid-electric planes will be able to use their new systems at take-off and landing and when needed on longer-haul flights use traditional aviation fuel. Zunum Aero predicts its electric propulsion system can cut emissions by 80 per cent.
But the planes are nowhere near ready to take flight – let alone carry passengers on a commercial basis. Omer Bar-Yohay, the CEO of Eviation, says the company plans to have a flying prototype of its nine-person passenger plane ready for the 2019 airshow. In a move that's "aggressive but not impossible", he says the company will attempt to get the plane certified with air authorities for 2021. Zunum claims it will have a 12-seater hybrid electric plane ready for 2022 and a 50-seater plane prepared by 2027. Airbus, Siemens and Rolls-Royce's test plane, the E-Fan X, is planned to have space for 100 people and its demonstrator plane could fly as soon as 2020.
A new era of supersonic flight is almost here. But nobody can agree on the right speed
The complexity of developing batteries powerful enough but light enough means smaller, personal flying cars are further off still and the aviation industry remains hopeful that hybrid planes will be able to carry more people over longer distances while significantly reducing carbon emissions.
Like electric flying cars, which are being touted as short-hope taxis in the sky, hybrid electric planes will also do most of their flying over small distances. "The majority of air traffic has consolidated to a very small number of large hubs," says Ashish Kumar, the CEO of Zunum. The company's first 12-seater plane will have a maximum range of 700 miles.
A quick guide to solar panels and home batteries in the UK
By WIRED
"Those [international] hubs work fine for medium to long-haul journeys but if you try to do a short journey, say under a 1,000 or 1,500-mile trip, through a hub the overhead of transmitting the hub is so great it kills the proposition of air travel." He estimates that 70 per cent of the time it takes to fly domestically in the US is spent shuffling around on the ground between security, transit and in innumerable queues.
Similarly, Eviation's Bar-Yohay says the firm's planes will focus on regional travel. "When we look at what happens when you want to travel 100 miles, 200, or 500 miles, what happens today is most people will hop in a car and drive for up to ten hours," he says. The company's plane – called Alice – is designed to fly for 650 miles at most. (In the UK, Land's End to John o' Groats is 874 miles at its shortest road route).
Given these distances, electric plane dreamers are hoping for a resurgence in small, unused airfields. In the UK there are more than 40 airports operating commercially. A government map shows sites from Gatwick, Stanstead and Heathrow to smaller, less used, airports at Lands End, Oban, and Lydd.
But there are also several hundred airfields, disused airports and landing sites that could be converted into minuscule but functioning airports. But there are plenty of hurdles that would need to be overcome: airports have complex tax structures, commercial airspace is tightly regulated and the infrastructure at unused sites would have to be overhauled. In addition, for electric planes, there would need to be sufficient charging facilities.
This doesn't put the electric plane startups off the idea of regional travel, though. "A lot of the secondary airfields in the UK are being looked at for redevelopment as traffic has moved out of them. Our view would be that's short-sighted," Kumar says. "The stock of airfields that exists in the UK and Europe are actually a very significant asset that would immediately get lit up by this class of aircraft that are coming in five or ten years time."
Here's the truth behind the biggest (and dumbest) battery myths
By Matt Reynolds
"This area of the market is dramatically underserved," adds Bar-Yohay. "You don't need to fly that fast if you're flying 500 miles."
Want to know more about the future of energy?
This article is part of our WIRED on Energy series. From the Chinese car firms taking on Tesla to the untapped power of poop, we're taking an in depth look at the technologies and ideas changing how we power our world.
Follow the hashtag #WIREDonEnergy on Twitter for all of our coverage.
London's sizzling heat island is bad news for your sweaty office
China is taking on Tesla's electric car supremacy (and winning)
The struggle to break the UK's addiction to big energy firms
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WIRED Awake
Extinction Rebellion's Heathrow drone protest is tearing it in two
By Sanjana Varghese
The best electric car concepts from the Shanghai Motor Show
By Jeremy White
Airport testing won't save Britain's summer holidays


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Live From Helsinki: Day Two At Flow Festival 2013
Clash takes you through Saturday's highlights...
ClashLive
ClashLive /
The uncommonly sultry weather continues in Helsinki, so Clash takes in a few sights before heading towards the festival: the remarkable timber-structured Chapel Of Silence, and the covetously cool shops in the design district. We're unanimously inspired by the desire to come back to this stylish city at our leisure.
It's too hot to stand still, so we ease ourselves in by sitting on the grass listening to the New York sounds of Tim Sweeney. Unsurprisingly he gets a serious groove on, and inspires high hopes for the evening. The Other Sound stage has consistently displayed exceptional artists, so we're curious to see Finnish band Lau Nau. They play experimental yet trad-based indie-folk melodies, which are by turn drone based, fragile and naïve, transfiguring into something harder, almost atonal, created from indigenous stringed instruments, bells, kazoos and loop pedals with shadow puppetry being projected live on stage. The entire effect in this seated hot space is to send us into near dreamlike rapture. We only feel these sonambulant effects for a very short time.
My Bloody Valentine are not the loudest Clash has ever heard them, but they're possibly the sweetest. Playing to a packed Nokia Blue Tent, we're entranced by a seamless succession of songs from both 'Loveless' and their latest album, 'm b v'. It feels nostalgic and near hallucinatory in the heat. Everyone feels giddy as we head across to the Black Tent to see the UK's Factory Floor. There's a surprisingly small crowd, but many people we speak to in Finland haven't yet heard of them, which is sure to change. Their set is a propulsive, blistering wall of noise taken from their forthcoming, DFA-released debut album. More accessible in sound that their industrial beginnings or collaborations with Chris & Cosey, this is New York heatwave, 99 Records, delirious dancing under broken fire hydrants music. It's brilliant.
We have to rush across to the main stage to catch the lion's share of Nick Cave & The Bad Seeds. He has become messianic, practically walking into the crowd, clasping hands to his breast. The version of 'Higgs Boson Blues' is a mastercraft in performance; charismatic just doesn't cover it. 'Stagger Lee' is malaevolently magnificence; 'Into My Arms' near tear inducing. Saint Nick has blown every other band we've seen these last two days away. We're in seriously mixed musical company, yet everyone agrees that this show is incredibly special, and that words can't capture the magic. So we won't try further.
We're all so buzzing that we're not sure where to go next. A colleague suggests Ebo Taylor & Odapajan, the Ghanaian band playing on architectural prize-winning Balloon Stage. They're a revelation of classic afrobeat played impeccably. People are literally dancing themselves into a trance.
The entire evening has been narcotic, like we've stumbled through the poppy fields from the Wizard Of Oz. Over half a dozen people we speak to, exiting the site, claim this to have been the most sublime four hours of live performance they've ever seen. It would be churlish to disagree.
Find words on Flow's first day's music here.
Find words on day three here.
Words: Anna Wilson
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Aphex Twin, Four Tet For The Warehouse Project


I felt it coming Tuesday...slowww moving, head kind of echoed, throat hurt when I swallowed. By that night I ached all over. Brandon took the boys to his parents Wedensday to play so I could rest. I felt bed sores coming on I slept so much. Yet I think another nap is in the near future. The boys dont really understand the "Mommy's Sick, let her sleep" routine yet. They want my attention anyway. And why shouldn't they? That is how it is! They stayed at Boss and Bebe's until Friday. Everyone was ready to be home as much as I wanted them to be home. First time I have been sick in a year, so when it hits it hits HARD! I guess if you dont slow down, your body makes you.


JT TALKS TO RICK REILLY ABOUT HIS NEW BOOK ABOUT TRUMP'S GOLF GAME. ALSO, HE CHATS WITH DR. JAY CALVERT (DR HOCKEY) ABOUT THE UPCOMING PLAYOFFS AND DISCUSSES THE NCAA CHAMPIONSHIP GAME.
JT THE BRICK TALKS ABOUT THE NCAA CHAMPIONSHIP GAME, ALSO HE TALKS TO RAIDER LEGEND BILL ROMANOWSKI ABOUT HIS WORKOUTS WITH ANTONIO BROWN AND BROADCASTER ROXY BERNSTEIN ON THE UPCOMING VGK/SAN JOSE SERIES.
JT THE BRICK TALKS ABOUT THE VGK LOSS TO ARIZONA WITH KEVIN BOLLINGER FROM FOX5 SPORTS. ALSO, HE DOES THE WEEKLY BOXING SEGMENT WITH JAMES "SMITTY" SMITH.
JT THE BRICK TALKS ABOUT THE UPCOMING RAIDERS DRAFT WITH GUESTS MICHAEL GEHLKEN FROM THE RJ AND RADIO LEGEND LEE "HACKSAW" HAMILTON.
IN HOUR TWO, JT TALKS TO UNLV HEAD FOOTBALL COACH TONY SANCHEZ, BARRY TOMPKINS FROM SHOWTIME BOXING AND JOHNNY KATZ.
LIVE FROM THE BROADCAST BOOTH AT T-MOBILE ARENA, JT TAKES CALLS FROM VGK FANS. GUESTS INCLUDE VGK BROADCASTER GARY LAWLESS, VGK DEFENSEMAN NICK HOLDEN, AND VGK GM GEORGE MCPHEE.
In the second hour, STEPH from 97.1 THE POINT joins JT in studio to talk all things RAIDERS. Also, Russell Baxter chimes in with NFL draft news, and JT takes calls for a chance to win VGK tickets.
In the first hour of the show, JT is joined by Joe Lisi and Lee Sterling. He also talks about Russell Westbrook's amazing night and the VGK game with Arizona tomorrow.
IN HOUR TWO, JT TAKES CALLS FROM VGK FANS. ALSO, FORMER OAKLAND RAIDER JAMES HARRIS JOINS US TO TALK RAIDERS LEGACY. AND, IN "THE NIGHTCAP", JT TALKS ABOUT ODELL BECKHAM JR'S PRESS CONFERENCE IN CLEVELAND.
JT THE BRICK DISCUSSES THE DEMISE OF THE AAF LEAGUE. ALSO, HE TALKS TO JEFF SHERMAN FROM THE WESTGATE ABOUT FINAL 4 WAGERING AND OUR OLD BUDDY ZIG FRACASSI FROM SIRIUS XM ABOUT THE VEGAS GOLDEN KNIGHTS.


We are seeking an Advanced Practice Provider (Physician Assistant or Nurse Practitioner) for the newly forming inpatient-based procedure team. The APP will perform procedures including, but not limited to, bone marrow aspirations and biopsies, penicillin skin testing, and other procedures as the team expands. Responsibilities may also include providing clinical support to the inpatient primary services as determined by procedure volume and operational needs. This is a great opportunity to be part of a new institutional team!
The ideal candidate for this position is experienced in performing procedures and knowledgeable of inpatient care and workflows.
Hours: 12 hour days, flexed to operational needs.


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Agents of Fandom
The Flash: How Zack Snyder Would Have Ended Barry's Story in Justice League 3
in DC, HBO Max, Lists, Movies
Peyton Manning March 31, 2021, 8:55 am
The four-hour runtime of the Snyder Cut did justice to all the Leaguers. But one of the main characters that Zack Snyder redeemed was Barry Allen. As far as character development is concerned, the Flash literally took super-fast baby steps when Joss Whedon handled him. But Snyder gave him a great arc and a lot of depth. In fact, there is no story where his version of Justice League would have worked without Barry Allen in it. He was the key to bringing Superman back, and he was the one who saved Earth after "the Unity" was formed. Just like the first film, Barry Allen would have been equally important (if not more) in Snyder's Justice League 2 and 3.
Over the years, the visionary director has revealed plenty of details about his plans for the Justice League sequels. Among those details, we got to know what was going to be next for Barry Allen. After the Snyder Cut, Barry Allen would have run directly into his solo movie, which was originally supposed to arrive in 2018. This is where he would have fought Leonard Snart aka Captain Cold, and probably some other Flash villains. That would have led the Scarlet Speedster directly to Justice League 2.
The Flash's Arc in Justice League 2
By the time we enter this film, Barry Allen and all the other superheroes would have become regular crime fighters. The world would have come to know of the Justice League. Snyder's Justice League 2 storyboards were recently leaked and they revealed how the team would have united to stop a natural disaster together at the beginning of the film. Meanwhile, Lex Luthor would have been assembling his own team of the Injustice League including Dr. Maru from Wonder Woman, Black Manta and Orm from Aquaman, and Leonard Snart from The Flash. Lex Luthor would have looked for the Anti-Life Equation while these villains would have gone up against the Leaguers. Talking about Captain Cold in particular, Luthor would have given him a major upgrade for his second round against Flash.
In the midst of all this, Barry would have successfully managed to reopen the case of his wrongfully convicted father. With the help of Bruce's army of Lawyers, Iris and Cyborg, Barry would have freed his father and cleared his name. Henry and Barry would have also shared some quality father-son moments outside prison. But things were going to take a darker turn as Darkseid would've appeared and taken the anti-life equation from Luthor. Thanks to the cynical genius, Darkseid would have killed Lois Lane in the Batcave and turned Superman against Earth. Then comes the Knightmare future where 5 years later, Earth falls to Darkseid's rule, and Barry is among the final few heroes of the resistance.
How Things Ended for the Flash in Justice League 3
Green Lantern would have been brought into the mix in Justice League 3, and he was supposed to become good friends with Barry. And, this is the film where Barry would prove to be the most important character. By now, he will have had even more adventures with Time Travel. So, his arc would have been to undo the Knightmare future using Time Travel. Bruce and his team would use the Mother Box to build the Cosmic Treadmill. With that, Barry would go back in time to warn Bruce about Lois Lane's death at the hands of Darkseid.
But you see, there's a condition attached. Traveling back in time through the Treadmill was very risky and it could only be done once a year. Furthermore, Barry would only get 10-15 seconds in order to tell Bruce whatever he wanted to say. And as we already saw in Batman V Superman, Barry's first attempt at time travel was not successful at all. "Am I too soon? I'm too soon." By this, he meant that he ended up going way back in time. He was supposed to go back in the Batcave right before Darkseid would kill Lois.
Then somehow after this failed attempt, the Resistance would survive another year. Along with Barry, Batman would have assembled Deathstroke, Joker, Cyborg & Mera in order to steal another Mother Box for the Cosmic Treadmill. Once they rebuild the "Time Machine," Barry would go back in time to the right moment this time. He'd warn Bruce about saving Lois. But this was their final chance because right after the warning, Barry would vanish out of existence.
The Final Battle of Earth
After Barry's warning, Bruce would have successfully saved Lois Lane by coming in the line of Darkseid's Omega Beams. By doing this, he'd undo the Knightmare future. Looking at his condition, Superman would once again go berserk. But this time, all his rage would be directed towards Darkseid. He'd lead an all-out war against Darkseid's army, and the Flash of the present would get a massive battle sequence. He'd take out an entire army of Parademons all by himself. After Bruce's sacrifice, Superman would lead a new team of Justice League including Barry Allen. From this point on, the Flash could have gotten a sequel if the Warners. would have deemed it necessary.
Sadly, none of the aforementioned plot points are coming to life as Warner Bros. is not interesting in restoring the SnyderVerse. They are doing their own Flashpoint Multiverse story with The Flash in 2022. We hope that it will manage to separate the SnyderVerse and the theatrical DCEU in a way that makes sense. That way, even if WB agrees to #RestoreTheSnyderVerse on HBO Max, they'd be able to do it while running their loosely connected solo DC movies in the theatres (which take place in a similar, but different Universe in DC's Multiverse).
BatmanCyborgJustice League 2Justice League 3knightmareLois LaneSupermanThe FlashZack Snyder's Justice League
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Written by Peyton Manning
Just wanna share my passion for cinema with everyone.
in DC, Franchises, HBO Max, Movies, News
Justice League: Zack Snyder Spoils His Plans for DCEU's "Avengers Assemble" Moment
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text:
Steven Spielberg >
Steven Spielberg says Tintin 2 is not dead
By Bang Showbiz in Movies / TV / Theatre on 26 March 2018
Follow Steven Spielberg
Steven Spielberg Jamie Bell Peter Jackson Daniel Craig Andy Serkis
Steven Spielberg has revealed Peter Jackson will be helming the highly anticipated 'Tintin 2' but said not to expect it for another three years.
Steven Spielberg has confirmed 'Tintin 2' ''is not dead''.
The 71-year-old filmmaker helmed the first instalment of the beloved Belgian journalist - with Jamie Bell voicing the titular character - and originally 'The Hobbit' helmer Peter Jackson was to take on directorial duties for an upcoming sequel.
However, since the first animated movie came out in 2011, news of the sequel had been quiet but now Spielberg has confirmed that Jackson ''has to do the second part''.
While promoting his latest film 'Ready Player One', Spielberg said: ''Peter Jackson has to do the second part.
''Normally, if all goes well, he will soon start working on the script.
''As is takes two years of animation work on the film, for you, I would not expect to see it for about three years.
''But Peter will stick to it. 'Tintin' is not dead!''
The first movie - which also featured the voices of Daniel Craig and Andy Serkis - follows the young reporter who buys a model of an old ship called the Unicorn.
However, the purchase sparks the attention of a shady character named Sakharine (Craig) but when Tintin refuses to sell the ship, he discovers it contains a clue about hidden treasure.
But before he could locate it, he is kidnapped and given over to the custody of drunken Captain Haddock (Serkis) and they embark on a journey to seek the treasure before Sakharine gets his hands on it.
The franchise was originally planned to be a sequel with Spielberg helming the first, followed by Jackson and the first director was unnamed.
Jackson is currently in post-production with his latest World War One biopic which is set to air this year on the BBC.
Unveiling the project, Jackson and his partners said: ''I've always been fascinated by the First World War due to my own family history and the centenary felt like a unique opportunity to make a personal contribution to the commemoration.
''I wanted to find a way to bring new life to the stories of ordinary people living through extraordinary times.
''The film will be broadcast on BBC One following a UK wide premiere as part of the BFI London Film Festival in 2018.
''The BBC will accompany the film with a 'making-of' documentary with behind-the-scenes footage, interviews with Peter Jackson and an in-depth look at the creative and technical process behind the work.''
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text:
Q: Neo4j: How can I display labels as nodes? I have a question about Neo4j. I need to show labels in my graph database as node - like if I have only two types of labels in my database (for example Thing and Person), I want to have 2 extra nodes - Thing and Person with relationships to normal nodes.
Example - I have this:

Orange node is Person, red is Thing. So I want to have extra label nodes for every label in graph. So I want this:

Can be this created automatically?

A: You do not really want to do that, since a visualization with N nodes would then have N extraneous relationships to the special "label" nodes, making it hard (or even impossible) to see the actual data. Using different colors for different labels is a good compromise.
In any case, the top of the result panel (in the neo4j Browser) tells you which color belongs to which label, so you can already easily get the information you want.
[UPDATE]
However, if you really need to do something like that, there is no "automated" way. But you could use some APOC procedures to create virtual nodes and relationships that are not stored in the DB,  but which can be visualized.
For example, if your original Cypher query is:
MATCH path=(p:Person)-[r:RELTYPE]->(t:Thing)
RETURN *

you can use this query to generate the appropriate virtual nodes and relationships:
MATCH path=(p:Person)-[r:RELTYPE]->(t:Thing)
WITH COLLECT(path) AS paths, COLLECT(DISTINCT p) AS ps, COLLECT(DISTINCT t) AS ts
CALL apoc.create.vNode(['V_Label'], {label: 'Person'}) YIELD node AS pLabel
CALL apoc.create.vNode(['V_Label'], {label: 'Thing'}) YIELD node AS tLabel
UNWIND ps AS person
CALL apoc.create.vRelationship(person, 'IS', {}, pLabel) YIELD rel AS pRel
WITH paths, ts, pLabel, tLabel, COLLECT(pRel) AS pRels
UNWIND ts AS thing
CALL apoc.create.vRelationship(thing, 'IS', {}, tLabel) YIELD rel AS tRel
RETURN *

A sample resulting visualization:

redpajama_set_name: RedPajamaStackExchange


West London UHNWI is looking for a dynamic life style PA to work in a predominately private capacity within his family office. Although this role will be London based there will be a considerable amount of international travel.
staff to ensure both business and private diaries are synchronized.
considered, a minimum of 18 months experience needed).


Being able to travel with my family is a blessing. We recently travelled to Hawaii to watch Brooklyn compete at the Aloha Gymnastics Festival. I wasn't sure what to expect but it was an awesome feeling knowing that she was there with her team to represent a sport that she loves doing.
As a parent I try not to get caught up in being that overbearing parent who wants their kid to win at any costs. We see it way too often, those crazy parents who blames everyone but the child for not winning. Here's how I see it, if your child is awesome, then count that blessing and congratulate them win or lose.
Brooklyn came away with a 1st place on the uneven bars and 3rd place all around. Congrats to her and all her team mates for doing an incredible job.


Roses are always a great, classic way to say 'I love you' while a bouquet of your loved one's favorite flowers is always perfect on Valentines Day. Sending roses is always a special occasion. Let The House of Flowers help you send this traditional romantic gift. They are also one of the most popular and recognized flowers in the world. No matter who you want to send flowers to, roses are a perfect choice. Send red roses for romance, white roses for respect, and yellow roses for friendship. Whatever rose you choose to send, The House of Flowers in Auburndale can help you!
The Dazzling Vase of 3 dozen red roses will be the thing everyone is talking about!
Bouquet of red roses, crimson tulips and pure white lilies in a unique twisting red shape vase.
this beautiful vase is full with baby breath and soft purple roses that anyone would just love to receive no matter what the occasion is.
this vase arrangement is available in the following colors: light pink, hot pink, white, and lavender.
12 Long stems Roses 6 red and 6 pink Or other color options available with mixed green and filler flower.
What a beautiful red vase filled with carnations, daisies, and roses. A sweet touch is a fun bracelet added on.
Roses Carnations Daises arranged in vase.
White Orchid in Exclusive Bamboo Cube.


Easy law school scholarships for students- just leave a review!
Law school scholarships are offered in two ways; internal scholarships, which are often offered by the school and alumni, as well as external scholarships, which are offered by other outside organizations. Law school scholarships may be based on merit (students who have performed well in their undergrad studies, at work, or on exams like the LSAT). Need-based law school scholarships are generally awarded to students who demonstrate a financial need. Below you will find our law school scholarship!
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The $500 LSAT Prep Courses Scholarship is open to all law school students and those planning on enrolling within 12 months. The winner will be determined by random drawing and then contacted directly and announced on LSATPREPCOURSES's website on the Scholarship page. One entry per person, read the official rules and FAQ's.


text:
Depth through thought
OUCC News 3rd June 1998
Volume 8, Number 13
DTT Volume 8 index
DTT Main Index
OUCC Home Page
Editor: guilford@ermine.ox.ac.uk
Rescue Practice
The rescue practice will be in WALES this Saturday. The reason for this change from the usual venue (i.e. Mendip) is to tempt those unable to resist the lure of Draenen into coming on the rescue practice.
The plan is to depart early on Saturday from Oxford (8am at the hut) and do the rescue practice that afternoon. Please bring full SRT kit and any pulleys, spare krabs etc. that you might have. We will stay at the WSG on Saturday night and on Sunday people are free to do whatever caving trips take their fancy. If you are planning a Draenen trip which will finish late, make sure you have sorted out transport. There will be no first aid course that weekend, but I believe Tim is sorting something out for another day in Oxford.
On a related topic, there will be SRT practices both this Friday and next, from 6pm under the south ring road bridge (first big bridge south of Donnington bridge). If the weather is bad then we will go to the New College School Gym.
Both the rescue practice and the SRT sessions are very useful, so please make the effort to come along and learn. They can also be quite fun!
Jo "alcohol induced haze" Whistler
Discount evening
There's a discount evening tomorrow at the Scout shop (Turl St.) at 5.30pm (don't be late). We'll be getting 15-20% discount off boots, rucksacks, sleeping bags, tents, fleeces, waterproofs, etc, etc. I'll have catalogues this evening.
Lev Bishop
Expedition Gear Sorting
Next weekend (end of 7th week, 13th-14th June) is AC Irvine interviews and no club trips. There's quite a lot of expedition gear that needs to be looked at and fixed if necessary. In particular tents need to be put up and tackle bags patched, as well as several other jobs. The more people helping out, the easier (and more fun) it will be. Anyone is welcome to come and help and anyone going on expedition should feel duty-bound to show up.
Puzzle corner
Identify the following lovely period piece, from a caving book of the 19**'s. Author, title, date ?
"Sailing, skiing and even climbing have obvious attractions for women: they can, if they wish, confine their public appearances to days which are really sunny, and even then not feel committed to do more than a token ten minutes of actual activity. The rest of the day can be spent sunbathing on deck, on the hotel balcony, or at the foot of the rocks, and the evening offers plenty of scope for sporting their latest après-whatever dresses.
"It seems strange, then, to find any women at all interested in caving, or actually down a cave. Yet there are precious few clubs without a reasonably large contingent of women, and some of the fairer sex - with smallness and a remarkable resistance to cold on their side - are nothing short of outstanding in modern caving. It is difficult enough to analyse the motives behind a man's decision to take up the sport, but even more so in the case of a woman. Perhaps many see a mainly male caving club as rich manhunting ground, but they would find it progressively more and more difficult to avoid committing themselves to actual caving trips. The enthusiasm of the caver to get any available non-caver underground can be quite astonishing, and psychologists would no doubt attribute this - in the case of the caving male and noncaving female - to some basic caveman motivation for the preservation of the species! It must be confessed here and now, though, that the irregular rumours of wild and passionate 'potholing orgies' (for some reason usually centred on Derbyshire) are without foundation. Underground amour, with its attendant difficulties of your being clad in a wetsuit, boiler suit and boots, is far too daunting a prospect."
Steve Roberts
After Chris Densham's Success in Pixie Meadows, OUCC has again been active at the other end of Draenen. Lev and Tim broke through a short bouldered squeeze in a miserable part of Blood River to find 100 metres or so of inlet passage several weeks ago. On May 24th they returned with Lou Maurice, Peter Bolt and Keith Hyams to survey the finds and to discover Lose Aven and several open leads. On May 31st Tim, Lev and Lou did a 14 hour trip to extend the complex series of inlet passages to a total of over 500 metres. Most significant is the discovery of a small stream passage (Blue Blood Streamway) which may prove to be the source of Out of the Blue.
Currently we plan to survey and tape the remaining open passages carefully before encouraging others to enter the Prisoners of War series. Many of the interconnecting passages contain delicate sediments, and it may prove possible to tape some off completely once we are convinced we know that they lead nowhere. We'd be grateful if fellow cavers would allow us a period of grace to complete this work before rushing in to investigate, or indeed grade 5 survey. Anyway, its a bloody long way to go to visit mudbanks. More details soon.
Tim Guilford
Afton Red Rift.
"Hmm, Afton Red Rift", said Paul. "Fun", "easy", "two hour", "bimble" said Paul, the only one of the four to have been down it before.
Well it immediately became apparent that the words "Red" and "Rift" were appropriate, my helmet was soon covered in the cave's distinctive mud, making me look like I had committed a particularly gruesome murder.
"Hmm, it is a bit more greasy than when I last came down here." We quickly found ourselves traversing in a very greasy rift. It was quite easy at first but quickly came to a slope down. Sliding down on the way in was fine, if the drop below was a bit intimidating. "I hope we don't have to go back up there," was the general consensus, but it was okay because we were doing the round trip. This was followed by a wider corner over a large drop, although it looks worse than it actually was.
Fortunately the worst of the rifts was then over. It was true some enjoyable furtling around that the fuck-ups started. See if you can guess who was involved in each one.
A). Person A. finds a promising lead through a duck. It goes absolutely nowhere and after a fruitless attempt at a squeeze that would have avoided the need to re do the duck, person A re-does the duck.
B). Person B goes through a descending squeeze headfirst on their back, getting their belt caught. Someone (who?) has to drag person B out of the squeeze by their feet, to cries of "pull harder, ooh, ugh!"
C). Person C gets to the top of a not-very difficult climb and suddenly develops a fear of heights. Totally pooing themselves, this person is eventually talked down.
D). Person D splits from the rest of the party to do the round trip, the others having been scared off by an unpleasant climb. Person D tries all four possible passages, each time reaching inpenetrable squeezes. Pausing for a breath, it is only by chance that this person spots a suspiciously worn stone on the floor, and bending down to inspect it finds a fifth crawl, and is so able to complete the trip, onwards and upwards to their next cock up.
E). Person E disagrees with a comment about a particular vertical tube "that must have been an interesting push". To prove their point, person E inserts him/herself into the hole in the floor. Soon realising that this was not such a good idea, person E completely fails to get out, and is only eventually released by much pulling up by their arms.
F) & G). To get up a somewhat tricky rift climb, everyone in turn stands on person F's knee. Person F, not finding standing on their own knee particularly effective, tries and fails to get up the climb unaided. Person G goes down to aid this person, who safely gets up the climb. Person G soon realises a flaw in this plan, not finding any spare knees to stand on, and fails to make the climb unaided. The problem is eventually solved with the construction of a large cairn.
H) & I). Back in the greasy rift, person H declares a particular section to be "possibly impossible". After being persuaded by logical argument that this was false, he/she doesn't find it to bad. Person I on the other hand requires the Elizabeth I approach. For a puddle substitute a rift, and a cloak a cavers body. Who needs traversing techniques when you have your own portable human chockstone?
J). After exiting the cave in one piece, person J sees no obvious route down a 10ft rock slab, so sitting on their bum, whoosh... into a tree.
Add to this many other panics and hiccups, and you have some idea of the incompetence of the team members. But as Keith said: "Excellent trip once it all started to go wrong".
Jo Whistler
I think this rather an unfair write up. We seem to forget that things went wrong before and after the trip:
K). Person K forgets to put the travelling line in the van.
L). Person L manages to navigate to completely the wrong hill side trying to find the cave.
M). Person M arranges to meet in the evening after the trip in a local pub, only to find it had burnt down a year ago.
Paul Mann
"I can hear the sky!", Keith at the far end of the cave. In fact the noise was probably from a "tractor".
And from Alison 'We're here for pleasure' Waterfall to Keith 'It's four years since I last filled something' Hyams:
"Keith, do you need pulling?"
Moving Members
Dave Horsely
d.horsley@abdn.ac.uk
4 Denend Cottages
Udny
AB41 6RU
Next Week: Diving in Brown Hill.....


According to the Kansas City Star, a jury in Wichita rendered a $23.5 million verdict against a truck driver and her employer, Swift Transportation for their role in causing a horrible truck wreck in 2006.
According to the lawsuit, truck driver Robyn Getchel missed her turn while trying to pull into a rest stop and was trying to back-up on the highway when she was rear-ended by another semi. The driver of the second rig, Dennis Bottorff, was killed instantly and his passenger, Terry Frederick, sufered severe spinal cord injuries leaving him completely disabled.
Likely driving the liability in this case were the facts that: (1) the at-fault driver was inexperienced (only driving for about 6 months), (2) had failed her commercial license exam several times, (3) had a history of drug use and (4) tested positive for methamphetamine in a post-acident drug test.
Everyday, big-rig semi-truck accidents occur all over Kentucky because companies, more concerned with profits than people, put inexperienced drivers behind the wheel. The companies place unrealistic schedules on the drivers which often leads to the drivers abusing amphetamines to stay awake to drive longer distances and fudging log book entries so they can avoid the federally mandated rest periods. Companies and drivers that operate in this careless manner have to be held accountable, regardless of whether it's in Wichita, Kansas or Louisville, Kentucky.
Please download our free report on Semi Truck accidents here and watch our video on "The 6 Things You Must Know if You Have Been Injured in a Car or Semi-Truck Wreck".


This year's predicted strong El Niño season is both good and bad news. If you live in Florida, the East Coast, or the Gulf of Mexico, the strong El Niño means there will be fewer and weaker hurricanes. That's the good news. Now for the bad news. If you live on the Pacific Coast, it means that the wet season will be worse and more dangerous than usual.
The last El Niño of similar strength — from December 26 through January 3, 1997 — brought over 20 inches of snow and rain in some locations in California. This can cause flooding, mudslides and agricultural disruption — and billions of dollars in losses. On a national level, there are 5,879,000 vehicle crashes each year, according to the U.S. Department of Transportation. Twenty-three percent of these accidents are weather-related. Rain and wet pavement accidents account for more than 80% of weather-related injuries, killing an average of 4,789 people a year nation wide. This is the highest of all the weather-related injuries, more than sleet, snow, ice and fog combined.
To avoid any accidents and to keep your family safe during the wet season, keep some smart, road safety tips in mind when you are out and about in the heavy seasonal rains, especially since the rains can produce limited visibility and local flooding faster than you can say "El Niño." First and foremost, make sure you are insured. You can check for a quick auto insurance comparison online.
You should heed the warning signs around you and try not to drive at all when the roads are soaked and possibly flooded from El Niño conditions. When you drive through pools of standing water you are in the greatest danger, as you can never truly know if the water is too deep for your vehicle until it is too late.
If you do find that your vehicle has quit running when you are stuck in standing water, the worst possible thing that you can do is to attempt to start it back up again. Starting your automobile again while you are in standing water only forces additional water into the engine compartment. This might then cost you thousands of dollars to fix.
Be certain that your tires possess sufficient tread depth and are correctly inflated. This is critical for your automobile to deliver superior maneuverability and traction on a wet and dangerous road. Tires that are too well worn and demonstrate too thin a tread naturally have a better chance of hydroplaning on the wet and slick surface. If this occurs, then you will lose steering and braking control.
The old standard trick to double check tread still works. Simply take a quarter and stick it upside down directly into the grooves on your tires. If at any place on the tire treads you are able to see the space over George Washington's head, then you need to invest in a new set of tires.
Cruise control may be a miraculous device when the roads are dry, but on a wet road surface it only elevates your chances of losing control over your car, truck, or SUV. Never use cruise control when it is raining. As you approach pools of water, take your foot off the accelerator to keep your vehicle from losing traction. Don't slam on your brakes! If you need to use your brakes to slow down quicker, do so but slowly.
This may sound obvious, but many drivers forget that rainy conditions on the roads often create low visibility situations. With your own headlights engaged, you can not only see others better, but they can see you better as well. Try not to resort to the high beams as they not only blind other drivers, but the additional light can reflect against the rain and distract you still more.
Though it goes without saying that your parents were right when they warned you about pulling off the road to a safe distance when you can no longer see the cars in front of or behind you, many people ignore this golden rule of poor visibility. If you are unable to see the road's edges or any other automobiles at a reasonable distance in the wet weather, then be sure to pull off of the road to a safe distance and wait out the downpour. Arrive alive is still practical advice.
In the event that your automobile stalls in a flood, never stay with your car. Get to higher ground without the vehicle as soon as you can. When flood waters rise, they do so rapidly, and this can cause the car and everyone in it to be swept completely away.
El Niño will have a different effect on different areas. The areas with the highest risk of flooding and mudslides will be coastal cities, especially those in the southwest U.S. as they are anticipated to receive both warm temperatures and heavy precipitation. It's already begun in some areas, and Californians have noticed the changes in the water. Though surfers may be loving the unusually warm water, this indicates the start of the El Niño season. Experts also say there is an 80 percent chance that the "weather anomaly" will last through Spring 2016.


text:
Q: how to filter list in c# using linq i am working on a ticket where there is a array of data i am passing as parameter to a method and based on the parameter and another date parameter i want filtered result but i am not able to get
that result
here is my code
public void Test1()
        {
            // Arrange
            var first = new Level
            {
                Code = "P3",
                Date= DateTime.Parse("01 March 2022")
            };
            var second = new Level
            {
                Code = "P3",
                Date= DateTime.Parse("01 April 2022")
            };
            var firstbrk = new Level
            {
                Code = "B1",
                Date = DateTime.Parse("01 March 2022")
            };
            var secondbrk = new Level
            {
                Code = "B1",
                Date= DateTime.Parse("01 April 2022")
            };
            var data = new[]
            {
                first ,
                second,
                firstbrk,
                secondbrk
            };

            // Act
            var main = Handler.GetExtras(data, DateTime.Parse("02 April 2022"));

            // Assert
            CollectionAssert.AreEquivalent(main , new[] { second, secondbrk });
        }

        [Test]
        public void Test2()
        {
            // Arrange
            var first= new Level
            {
                Code = "A3",
                Date= DateTime.Parse("01 March 2022")
            };
            var second= new Level
            {
                Code = "A3",
                Date= DateTime.Parse("01 April 2022")
            };
            var firstbrk= new Level
            {
                Code = "B1",
                Date = DateTime.Parse("01 March 2022")
            };
            var secondbrk = new Level
            {
                Code = "B1",
                Date= DateTime.Parse("01 April 2022")
            };
            var data= new[]
            {
                second,
                first,
                sceondbrk,
                firstbrk
            };

            // Act
            var main = Handler.GetExtras(data, DateTime.Parse("02 April 2022"));

            // Assert
            CollectionAssert.AreEquivalent(main, new[] { second, secondbrk });
        }

Here is handler code
  public static IEnumerable<Extra> GetExtras(IEnumerable<Extra> main, DateTime idate)
        {

            return main.GroupBy(x => x.Code).Select(x => x.LastOrDefault(x => x.Date< idate));

        }

Here in handler code the issue is only test1 is satisfying test2 is not working because of LastOrDefault used
i want the the input which is supplier to handler method should be first filtered based on Code
so with every code it should get the data and then with that it should check that Date from the class Extra should be less than idate and then only latest date from the group of that particular code should get picked
e.g
if date is 2 March 2022 and 2 April 2022 for code T3
and date is 5 march 2022 and 1 April 2022 for code B1 and i date is 5 April
so for code T3 2 April should get picked and for code B1 1 April Should get picked
also if input is sent in incorrect order like Test case Test2 then it should order the input in
proper order and then do above stuff
Thanks in advance for help

A: This looks extremely similar to this question, except that here you want the one entry that matches the criteria for each Code. I am reusing logic from the answer that I gave for the other question here, but using .GroupBy() to group by Code:
public static IEnumerable<Extra> FetchExtras(Extra[] lvl, DateTime idate)
{
    return lvl
        .GroupBy(extra => extra.Code)
        .Select(gr => gr.Where(x => x.Date < idate).MaxBy(x => x.Date));
}

.MaxBy() is available from System.Linq from .Net 6.

A: you have to fix GetExtras method since your class name Level, not Extra
And you can not group your data , it will be the same
public static IEnumerable<Level> GetExtras(IEnumerable<Level> main, DateTime idate)
{
    return main.Where(x => x.Date < idate).OrderByDescending(x => x.Date).Take(1);
}

if you still want to group you can use this code, but result will be the same
public static IEnumerable<Level> GetExtras(IEnumerable<Level> main, DateTime idate)
{
    return main.GroupBy(x => new { x.Code, x.Date }).Where(x => x.Key.Date < idate)
    .Select( x=> new Level {Code= x.Key.Code, Date= x.Key.Date}).OrderByDescending(x => x.Date).Take(1);
}