Chris Riding, Matisse's Music Chris Riding considers focus Matisse's paintings 'The Music Lesson' (1917) and 'The Piano Lesson' (1916) in relation to the formalist theories of Roger Fry and Clement Greenberg.Further ReadingG.Perry 'The expanding field: Ana Mendieta's Silueta Series' in J. Gaiger, ed, Frameworks for Modern Art, Yale UP/OU, 2004.J.Blocker, Where is Ana Mendieta, Duke University Press, 1999.
Gill Perry, Sculpture and Performance in Ana Mendieta's Silueta Series Studies of Mendieta's work have frequently interpreted her earth/body art as both instilled with primitivist fantasies of a feminine primordial power, and an obsessive response to trauma and loss.
Gill Perry, Introduction to the Themes of the Day Germaine Greer has described Kahlo as 'the first ever true performance artist'. Gill Perry considers this claim in relation to recent debates about the meanings of performance art, and in comparison with the activities of a later generation of women artists, including the work of Carolee Schneemann, Ana Mendieta and Hannah Wilke from the 1960s and 70s.


If you're new to Twitter, here's an overview on how the #echat hashtags (and similar ones such as #edtech or #K12) can be a great way to expand your knowledge and gain valuable insights into education.
Need even more help? Visit IU19 and suggest a "how to set up Twitter for education" video tutorial in the IU19 Question/Suggestion Box.


The lake in Cenote Angelica is not entirely unique but nevertheless no other place in the world has brought such impressive sights and images. Deep in this lake is a weird, gloomy fog which constantly is in the move. Below this layer of mist is the next layer of water – lifeless, dark realm behind the eternal mist.
Nowhere else in the world exists such landscape as in Yucatan Peninsula, Mexico. Here have been found at least 7 000 cenotes – specific sinkholes which formed when above the countless water-filled cave passages the limestone roof collapsed opening a view on deep blue cave lake.
Quite a few of these cenotes are unusual and even unique – some contain carcasses of long-extinct animals, others have rich finds of ancient Maya offerings, some have weird light effects and others – unique, bell-shaped stalactites.
Cenote Angelica has its own peculiarity. This cenote is 57.5 m deep – one of the deepest. But at first, it may seem that its bottom is at the depth of some 30 – 33 meters. Here it looks like the clear, calm water meets something otherworldly – a constantly moving white cloud.
From above cenote Angelica does not look like anything special. The small pond in the rainforest looks even uninviting – the water looks a bit dirty.
But when the divers descend into this small lake – it turns out that somewhat deeper the lake becomes lucid. As they move deeper and deeper, less light gets through the mass of water only spooky blue and green hues remain. And, yes, there it comes – the somewhat nightmarish, moving cloud.
At first, it may look like a bottom of the lake. Or – rather a shore of some boiling lake. Around its "shores" one can see the fallen leaves from the trees far above the lake. Some tree branches are sticking out from the fog.
Divers descend in the white fog – and, it turns out, the lake continues below it! After moving through some 2 – 3 m thick layer of "foggy" water divers reach lucid, dark water below it. As they go through the cloud, a pungent odour of sulfur manages to pass the oxygen mask – and there it comes, the eternal darkness of dead water below this weird cloud.
Cenote Angelita is rather close to the sea. It has vertical sides with the trees overhanging over it and it is very deep. These factors together cause unusual phenomena.
This can be explained through several scientific terms.
First word – lentic. Lentic ecosystems are those ecosystems which form in stagnant waters. If something – leaf, branch or buffalo falls in lentic waterbody – it stays there and decomposes. There are quite many such waterbodies around the world – and over the time these stagnant lakes or pools turn into swamps. But often this takes a lot of time – especially if this pool or lake has vertical, high banks and is deep. Just like Cenote Angelita.
Second word – anchialine. Anchialine waterbodies are lakes or ponds which are located near the sea or ocean and consist of two layers of water. Above is a layer of fresh or brackish water formed by the rain and/or small streams. Below is sea water, which enters from the sea through a cave or seeps through the ground. Cenote Angelita is some 12 km from the sea but the land here is just 10 metres above the sea level. Extensive cave and fissure networks reach from the sea far inland. Cenote Angelita is such anchialine waterbody with a layer of seawater at the depth of some 33 – 35 m.
Third word – meromictic. A meromictic lake is a lake with several layers of water, which do not mix together. This might sound rare and exotic but in reality, quite many lakes around the world have such layers of water. Usually, the bottom layer is without oxygen, dead and often with dissolved salts. The upper layer is, well, the usual lake water.
And finally – fourth word – chemocline. This is the border between two chemically different layers of water. The gloomy fog in Cenote Angelita is chemocline – a place where fresh water turns into salty seawater.
Chemoclines are observed in many cenotes near the sea. But this is a special one. Organic matter which falls in Cenote Angelica often does not pass through the chemocline – sometimes smaller leaves are just floating in it. As this organic matter decomposes, the toxic hydrogen sulfate is produced. This substance as well, as swarms of microorganisms form the "fog". Light can not pass through it – thus the lifeless seawater below it is in eternal darkness. If something falls in Cenote Angelita – it is lost forever – none can find it in the complete darkness and thick layer of sludge on "real" bottom.
As the water is in a slight movement, it may seem that the "fog" is a kind of underwater river. Nevertheless, this is not a river – water here is stagnant.
Diving in this unique cenote is rather dangerous – but it is an adventure of the lifetime! Well, divers gave a nickname to this site – "The Nightmare" – but what a weirdly beautiful nightmare it is!
Bec Crew, Divers Are Exploring This Giant Underwater River, Shrouded in a Cloud of Toxic Gas, Sciencealert, accessed in 8th November 2018.
Area of this country was a cradle of several highly developed indigenous civilizations and some regions in the country are dotted with remnants of ancient cities with temples, palaces and pyramids.
A Complete Guide for Snorkeling, Cavern and Cave Diving the Cenotes of the Riviera Maya. This book includes over 200+ color photographs and provides details of where and how to swim, dive and enjoy these beautiful cenotes located on the Caribbean coast of Mexico's Yucatan peninsula.


DRIFT MATSURI: SUMMER 2019 EVENT INFO - The Zeroclass Co.
One HUGE Drift Motorsport inspired event for all grassroots and pro level drivers!
Hardpark, Epic Live Entertainment and unbelievably Delicious Street Food.
"Drift Matsuri is New Zealand's destination grassroots drift event happening two to three times per year and is not to be missed. Drivers from the far north to as far as Invercargill make their way to the central North Island for one unbeatable weekend."
Awards and prizes up for grabs!
Advanced drivers are able to switch between tracks for some sessions on the club circuit if they have a group of a similar skilled people to drift with after lunch aslong as sessions are free on Track 3.
Weekend passes will be released first, followed by individual days at a later date pending availability.


a @album: Long Distance Voyagersongs/moodyblu/long. Txt How To Remove Meta-characters From User-Supplied Data In CGI Scriptssecurity/cgisecure. Floyd PThe dark side of the moon. QueenA Night At The Opera. Txt Cohen LSongs of Love and Hate The Various Collection of the best songs of Leonard Cohensongs/cohen/bestcohen. Txt year H nGreetingsanekdoty/newyear. Txt @album: Every Good Boy Deserves Favoursongs/moodyblu/every. Txt Twins Cohen LDeath of a Ladies' Man. Txt DoorsSongs with chords and tabssongs/doors/doorscrd. Txt The Song of Igor's Campaign, Igor son of Svyatoslav and grandson of Olegnabokow/slovo. Txt Meet Me Halfway songs/moodyblu/meet_me_.txt Melancholy Mansongs/moodyblu/melancho. Floyd PThe Best Of Pink Floyd. Txt Cave NKicking Against the Pricks. Txt Schwarz E LDragonshwarc/dragon_engl. (Sep Cohen LSongs from a Room. Txt Roger Zelazny Interviewzelqzny/zelinter. Txt Pelevin VOmon Rapelewin/omon_engl. Txt Wilde OThe Canterville Ghostwilde/ghost. Txt Hackalot sunix: A Hacking Tutorial. Txt Floyd PRelics Floyd PA saucerful of secrets. Txt Cohen LI'm Your Man. Txt Pelevin VSigmund in a Cafepelewin/sigmund_en. Txt VoivodTHE outer limits VoivodWAR AND pain medicine for abscessed tooth pain (p)1984songs/voivod/wap. Txt Oldie H LThe prophetoldi/prophet_engl. Txt Voivoddimention hatross (p)1988songs/voivod/dh. Txt other some songssongs/somesong.
Txt Zelazny RSalesman TalezelqznySalesmanTale, txt Mikes GHow to be an Alienanekdotymikes1. Txt Nabokov VSartreapos, son A Maiden ivirtual, s first pain medicine for abscessed tooth try ReviewnabokowSartre. Txt bookends Bridge Over Troubled Watersongssimonbridge. P floyd PThe Wall, txt Carroll LThrough the looking glasscarrolllglass. Txt Grin AThe ships in Lissrusslitgrinlissengl. Floyd PObscured by clouds, txt Wednesday Morning 3 Am Paul Simon Garfunkelsongssimonwm3am. Txt anekdotymilitia, txt Songs of Elvis Presleysongspresley, txt Sterling BCyberpunk in the Sterling BGurpsapos. Labour loststerlingbjackson, txt Veller MThe Guruwellerrteacherengl, txt Sterling BArtificial lifesterlingbfsf04.
A significant amount of research has focused on determining the processes that initiate tooth development.The main reasons for tooth loss are decay and periodontal disease.
Txt Baum L FThe marvelous land of Ozbaumozland. Txt Zelazny REye of catzelqznyeyeofcat, moody Bluessongsmoodybludreams 35 GMT, mon. Txt Lastmodified, txt song Your Wildest Dreams The other side of life. Txt Mikhail Bulgakov in the Western World A Bibliography bulgakowlcbulgbib. Txt Webber A LJesus Christ superstar p 1970songsjesus. Txt I burn FOR YOU stingsongsstingiburnf 03, txt Lee ATen Years Aftersongsleetenyears, queenA Day At The Races. Txt Zelazny RAnd I Only Am Escaped to Tell Theezelqznyandionly. Txt January Starssongsstingjanuary, txt Greatest hitsThe Best of Leonard Cohensongscohenmaster0. Txt nothing like THE aldgate coffee shop sunsongsstingnothing, txt THE rhythm OF THE saints p1990songssimonrythm 0 User Manualsecuritycrackfaq, txt Transparent Cryptographic File System for Linux Announcesecuritylinuxtcfs. Txt Crack 02, txt Abacus Sentry Port Scan Detectorsecurityabacus.
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Txt The Uncollected Stories of Roger Zelaznyzelqzny/stories.Txt Zelazny RThe Doors of His Face, The Lamps of His Zelazny RThe Great Slow Zelazny RThe Man Who Loved the Zelazny RThe Monster and the Zelazny RThe Night Has 999 Zelazny RThe Shroudling and the Zelazny RThis Moment of the Zelazny RThis Mortal timeline.Txt The best of rolling stonessongs/rolling/bestof.
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Lecture 9 will focus on the changes that occur politically and religiously in regards to a missionary's aim. We will be looking briefly at colonialism, Marxism/Communism, Liberalism & Secularism.
The missionaries we have looked at have often tried very hard not to simply give a European Christianity to those they preached to – that wasn't the aim. Introducing them to Jesus was the aim, and it was better to be done in someone's own language, their culture, their worship music, etc. However, despite their best efforts Christianity had been spread most widely when it came with the European expansions, business, trade, government, etc.
This is commonly known as Colonialism. Colonies, settlements from Britain, France, Holland, Spain and Portugal had been started in Asia, Africa, America. These places were in a way ruled by those people who had come. The result of this includes the horrors of slavery. Power often brings corruption and even though missionaries had tried their best, governments didn't necessarily treat the people living in these countries very well at all. We've seen this in the film The Mission, but it happened many other places too.
This gradually started to fall apart as countries realised that the idea of "Christendom" led by Europe was a myth. The West could no longer claim to be the only true civilisation or the only Christian place, and lost the influence it once had.
At the same time the Russian revolution had started, and it was a large anti-Christian force led by the Marxists. Marxism was an economic and social philosophy which wanted to get rid of capitalism, rulers, the monarchy, and instead to share power, wealth and lands out equally. As the European countries had ruled people with capitalism and Christianity, Christianity was rejected too.
"Religion is the opiat of the masses". It was felt by Marxists that religion had been used to get people to obey, so the upper class could keep the riches to themselves. The Royal family in Russia were murdered, and Russian Communism soon included banning all religion, including Christianity. Christians were persecuted and still are in certain Communist countries, for example, China.
In one way the Communists were right in that Europe had treated other people badly. It was sadly wrong in assuming Christianity was the reason. The link between government and religion is rarely a good one.
This gave missionaries far more issues to go up against. Communism spread and the political reaction against it caused all sorts of issues.In South America missionaries, nuns and monks were killed just for showing kindness to the poor. People were tortured, and there are still families whose loved ones just disappeared never to be found.
Alongside this there was a change in the attitude towards other religions. Liberalism suggested that conversion was outdated, that Jesus might not be the only way, and that religions should work together. This is also where the idea of pluralism came from. Pluralism suggests that all religions can be true, that truth is relative. Unfortunately pluralism disagrees with its own argument, so was never a good way to go.
With liberalism there came secularism. Liberals asked for all religions to tell us about a spirituality within our lives. Secularism called it all superstition and asked for no religions at all. Still both of these meant that the certainty of a missionary was in question.
Still missionaries were going forth into countries across the world, and a large proportion of them were from the USA (27,733 out of 43,000). Christianity had expanded massively in the United States and this had happened mostly in the non-denominational groups. Pentecostalism had increased and lay a particular stress on the doctrine of the Holy Spirit. Many of these groups went to those countries and places which had a high degree of poverty and where people were in the greatest need for help.
We will be looking more at how modern missions has worked in these situations next week, and I will be suggesting some amazing books to go any read.


text:
Q: Laravel - Select just one row from pivot table and return data Currently, for a user, I can return all matches correctly.
public function getMatches()
{
    $matches = Criteria::whereUserId( Auth::id() )
    ->has('alerts')
    ->with('alerts.location', 'alerts.user.companies')
    ->get();

    $this->layout->content = View::make('users.alert.matches',
        array('matches' => $matches));
}

Relationship:
A Criteria belongsToMany Alerts and an Alert belongsToMany Criterias.
Problem:
If the user wishes to see more information about a certain match, I want to get just that result from the database. On my view, I can access the criteria_id inside the first forloop, and the alert_id inside the second forloop.
@foreach($matches as $match)
    {{$match->id}}
        @foreach($match->alerts as $alert)
            {{$alert->id}}
        @endforeach
@endforeach

But how can I use these variables to select just one pivot table match that the user wants to view more information about?
If a user was to select a certain {{$alert->id}}, how do I find which criteria_id relates to that alert_id, and then query the database to return the just that row of information, both from the criteria table and alert table, along with the with-> statement shown above.
Many thanks for your help.

A: I think you can include the data in your pivot table to your eager loading, like this:
public function getMatches()
{
    $matches = Criteria::whereUserId( Auth::id() )
    ->has('alerts')
    ->with('alerts.location', 'alerts.user.companies')
    ->withPivot('foo', 'bar'); //pivot table columns you need from pivot table criteria_alert
    ->get();

    $this->layout->content = View::make('users.alert.matches',
        array('matches' => $matches));
}

And access it like this:
@foreach($matches as $match)
    {{$match->id}}
        @foreach($match->alerts as $alert)
            {{$match->pivot->foo}} // pivot table data
            {{$alert->id}}
        @endforeach
@endforeach

Check out the laravel documentation for more details.
Also, this might help you simplify your code:
$matches = Auth::user()->with('criterias', 'criterias.alert')->get();

With your criteria to alert relationship like this:
return $this->belongsToMany('Alert')->withPivot('foo', 'bar');

Hope this helps.

redpajama_set_name: RedPajamaStackExchange


text:
LCBO stores raise funds for The Hearing Foundation of Canada
S tarting February 2, the public can help support The Hearing Foundation of Canada by making a donation at any of the more than 635 LCBO stores throughout Ontario. Donation boxes for The Hearing Foundation of Canada will be displayed at LCBO checkout counters until March 1.
The Hearing Foundation of Canada is committed to eliminating the devastating effects of hearing loss on the quality of life of Canada, particularly youth, by promoting prevention, early diagnosis, leading-edge medical research and successful intervention. The donations made through the LCBO's Provincial Donation Box Program will help to advance hearing health initiatives across Ontario. The Hearing Foundation has been delivering Sound Sense, a noise-induced hearing loss prevention education program, in Ontario, since 2005 and has taught approximately 300,000 children to save their hearing for the music.
"We appreciate the support we receive from LCBO, its employees and especially its customers," says Janice Eales, Acting President of The Hearing Foundation of Canada. "LCBO's province-wide store network and supportive staff will help us raise significant funds and increase public awareness of the importance of hearing protection for our youth and hearing health for all Canadians."
"LCBO is pleased to partner with The Hearing Foundation of Canada and support a variety of worthy causes throughout the year," says LCBO President & CEO Bob Peter. "The generous support from LCBO customers and staff help these charitable organizations make a meaningful difference in the lives of individuals and communities across Ontario."
The Hearing Foundation of Canada is one of 28 provincial and numerous local charities that will benefit from LCBO's province-wide donation box program in 2014. In 2012, LCBO raised a total of more than $6.6 million for charities through special programs and initiatives, of which $6.1 million was raised through in-store fundraising. In addition, LCBO's annual dividend transfer to the Ontario government, which totaled $1.7 billion in fiscal 2012-13, excluding taxes, supports a wide range of important government programs, services and priorities, including health care and education.
The Hearing Foundation of Canada thanks the public for its support when shopping at their local LCBO store from February 2 – March 1, 2014.
SeekersAdmin
Bishop MacDonell School Races for Literacy

redpajama_set_name: RedPajamaCommonCrawl


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Marriott Vacation Club Worldwide makes use of the Marriott marks under license from Marriott Worldwide, Inc. Use a couple of minutes in a crew meeting to share among the analysis on the benefits of vacation. After completing five years of employment, an employee becomes entitled to three weeks of annual vacation.
Download a duplicate or request a FREE printed copy of our 2017 Gulf Shores and Orange Seashore Vacation Guide. An employer must provide an worker with an announcement of earnings that features vacation pay, at the end of each pay interval. Retweet adalah cara tercepat untuk menyebarkan Tweet orang lain ke pengikut Anda.
The article also highlights the risks of foregoing vacation by way of impulsiveness, poor concentration, and negativity. Vacation Care operates Monday to Friday 7:30am – 6:15pm in gazetted college holidays. To order guides NOT included within the Alabama Gulf Coast Vacation Guide, please choose from the options under.
Make the most of that creativity by scheduling an extra-lengthy assembly with the person a number of days after vacation. At first, the expertise disconcerted my patient, who had fastidiously planned his vacation to the minute. Nonetheless, upon worker request and if the employer agrees, an worker can take vacation with pay earlier than finishing a full 12 months of employment.


text:
Home / Presidents / Vice Presidents / A Journal of Reparations
A Journal of Reparations
First English Edition | First Impression
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SKU: 12941 Categories: International Politics, Military History, Vice Presidents
First edition of A Journal of Reparations by Vice President Charles G. Dawes, inscribed to Robert H. McCormick of Chicago.
Octavo, xxxv, 527pp. Maroon cloth, title in gilt on spine. No additional printings mentioned. Light dust along top edge of text block, some rubbing to spine, a near fine example. Complete with a frontispiece portrait and seven full-page photographs. Includes the exceptionally scarce dust jacket, retail price stamped on front flap, splash mark to front cover, light toning to spine, a very good example. Inscribed on the front free endpaper: "For my friend Robert H. McCormick, from Charles G. Dawes. July 13th, 1939." The recipient of this book, Robert H. McCormick was a real estate developer in Chicago and the great-grandson of Leander McCormick, found of International Harvester.
A Journal of Reparations recounts the work of the Allied Reparations Commission of 1923, which developed a plan to resolve the issue of World War I reparations from Germany. What became known as the "Dawes Plan" ended a diplomatic crisis that followed the signing of the Treaty of Versailles. Charles Dawes shared the Nobel Peace Prize for 1925 for his work in resolving this crisis, which helped Germany reestablish the backbone of their economy. In the long-run, the reemergence of Germany as an industrial power would lead to military buildups and eventually World War II.
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Senate Minority Whip Richard J. Durbin has launched a new offensive against a familiar foe: electronic cigarettes.
For years, the Illinois Democrat has been alarmed by the use of e-cigs by young adults — and flavorings that seem designed to appeal to kids, like gummy bear.
Durbin was in Chicago on Monday to announce his latest effort. He plans to introduce a bipartisan bill with Sen. Lisa Murkowski, R-Alaska, that would impose new restrictions on electronic cigarettes, unless manufacturers can show to the Food and Drug Administration, within one year, that flavorings that seem child-friendly are really smoking cessation devices.
Durbin's previously been involved in other legislative efforts designed to curtail e-cigarette usage, and also called on Hollywood to avoid encouraging the practice.
Durbin led a group of Senate Democrats in calling the e-cigs, "candy-flavored poisons" back in a 2014 letter to the then-commissioner of the FDA.
The legislation announced Monday also would require a prohibition on flavored cigars, citing the existing ban on flavorings other than menthol for traditional cigarettes.


Robert Lusby of AA Co. d. leaving a will dated 2 June 1733, proved 25 Aug 1733, naming children: Robert (to have Chilberry Hall in BA Co.), Jacob, Mary Turpine, Hannah Drew, Naomi Ghiselin, Susannah, Milcah, Zachary, Draper, Henry, Joseph. Sons Zachary and Draper to be execs. (B: MCW 7:44, cites MWB 20:813).
On 7 Dec 1733 Robert Lusby's estate was appraised by Ezekiel Gillis and John Andrews, and valued at L214.14.7. William Stevenson and Susannah Lusby signed as creditors, and Susanna Lusby and Naomi Ghiselin signed as next of kin.
The inventory was filed on 31 Dec 1733 by execs. Thomas Jobson, Zachariah Lusby and Draper Lusby. (MINV 18:176).
ROBERT, named in father's will.
[S47] Will, Robert Lusby, Sr. 1667-1733, (MARYLAND CALENDAR OF WILLS: Volume 7 - Jun 1733).
[S2544] Will - Lawrence Draper, Sr.
[S3047] Early Colonial Settlers of Southern Maryland and Virginia's Northern Neck Counties.
[S77] Colonial Families of the Eastern Shore of Maryland, (Family Line Publications, Rear 63 East Main Street, Westminster, Maryland 21157, 1996), Will.


William WARNER (1594 – 1648) may not have been Alex's 11th Great Grandfather; one of 4,096 in this generation of the Miller line.
William Warner was born in 20 Oct 1594 in Boxted, Essex, England. His parents were Samuel WARNER and Mary DOWNING. He married Abigail BAKER in 1611. William came to America with his three children and was in Ipswich, Mass. before 1637. It is said by some Warner genealogists that they sailed on the ship,"Increase" in 1635, but he does not appear on the passenger list. William died in 1648 in Ipswich Mass and is interred at High Street Cemetery, Ipswich, Essex Co., Mass.
Abigail Baker was born in 1590 in Boxted, Essex, England. Her parents were John BAKER and [__?__]. It appears as though Abigail remained behind to nurse her mother when her husband left Boxted in 1635 on the "Susan and Ellen." The mother did not accompany the family to America. It is likely that Abigail died prior to the rest of the family leaving for the New World.
10 MAR 1654/55 17 May 1692 Hadley, Hampshire, Mass.
2 Jun 1641 in Ipswich Mass.. 9 Sep 1688 in Ipswich, Mass.
It is said by some Warner genealogists William WARNER and three children sailed on the ship,"Increase" I just see William's son John listed , perhaps as a servant of Matthew Marvyn.
56 Warner Jo, 20, listed below Marvyns (John from Boxted, Essex, bound for Ipswich).
William Warner, a weaver, settled in Ipswich, Mass. in 1637 with his two sons, John and Daniel, and his daughter, Abigail. Where they lived in Boxted is in some doubt. The name given to their house was "Merrylees Cottage" which is not traceable. After his arrival in Massachusetts, Thomas Wells was granted five acres of meadowland in the name of his father-in-law, William Warner, at Ipswich, Mass.
2 May 1638 – William was admitted a freeman. Any man entering a colony or becoming a member the church, was not free. He was not forced to work, but his movements were carefully observed to see if they followed the Puritanical ideal. After this probationary period, he became a "freeman." Men then took the Oath of a Freeman where they vowed to defend the Commonwealth and not to overthrow the government.
1637 – The town of Ipswich grants William one house lot, one acre, more or less, on the Mill Street., bounded on the east by another house lot not yet granted (It was later occupied by his brother-in-law Lumpkin),on the N.E. by the highway leading from the mill Street. to the High St., butting on the Mill St. at the S.W. end , at the north end butting upon the swamp. Also a planting lot of six acres more or less, meadow and upland, and a farm of ninety and seven acres more or less, also a parcel of meadow, lying in the west meadows, being fourteen acres more or less." The town of Ipswich was established on August 5, 1634, from common land called Agawam.
The acre lot on the corner of the Lane, known as Baker's Lane, was granted to Wm. Warner, 1636. Edward Chapman owned in 1667 and sold Edward Lummus "my dwelling house wherein sd Lummus dwells" with barn and one and one quarter acres, "the Street called Mill St. toward southwest, and the house and land of widow Stacy southeast," March 2. 1667 (Ips. Deeds 5: 190). Edward Lomas conveyed to his son, Jonathan, his homestead, house, barn and an acre of land, and twelve acres purchased of Mr. Cogswell, May 25, 1682 (Ips. Deeds 4: 466). His will (Ips. Deeds 4: 476) states that the twelve acres were on the opposite side of the Street. Jonathan Lumas sold Daniel Rogers, schoolmaster, "the house in which he now dwells" with two .acres, Thos. Wait's homestead southeast, June 18,1712 (25:1).
But among the large number of those who for the sake of civil and religious freedom came to this country in the great period of emigration, between the years 1620 and 1640, were William Warner of Ipswich, England, and his family including three children, who with his pastor settled in 1637 in Ipswich—one of the foremost towns in the colony in the intelligence and worth of character and thrift of its earlier inhabitants, as it was one of the oldest in settlement.
A few years after its founding in 1633, the historian Johnson recorded the fact that "the peopling of this town is by men of good rank and quality, many of them having the yearly revenue of large lands in England before they came to this wilderness." And in 1638 Cotton Mather wrote concerning it: "Here was a renowned church consisting mostly of such illuminated Christians, that their pastors, in the exercise of their ministry might think that they had to do not so much with disciples as judges." Of this church William Warner was a member, he died before the year 1648.
Abigail's sister Sarah Baker was born 1593 in Boxted, Essex, England. Sarah married Richard Lumpkin on 20 Oct 1614 at St. Peter's church by George Phillips in Boxted, Essex, England. Sarah died Jul 1663 in Cambridge, Middlesex, Massachusetts.
Richard Lumpkin was christened 16 Dec 1582 in Boxted, Essex, England. He died Nov 1642 in Ipswich, Essex, Massachusetts.
Sarah and Richard also immigrated in 1637 from Boxted. Richard Lumpkin became a farmer and lived at Parsonage Farm, Church Street. Sarah and Richard settled in Ipswich, Mass. at the same time as William Warner. Relatives of Sarah (Baker) Lumpkin settled in Charlestown. Accompanying the Lumpkins was William Bartholomew, a farm labourer, married to Ann Stone. There is also a record showing that William Warner and William Bartholomew were appointed to lay out land granted to Richard Lumpkin and William Whittered. His family were spoken of as 'people of consideration'.
It is probable that Richard Lumpkin took the house lot next to the Warners and that he farmed the 97 acres of Warner's land. He died in 1642 and his widow, Sarah, married Simon Stone of Watertown in 1654. On Nov 10, 1654 Sarah Stone, née Baker ex Lumpkin, deeded to Daniel Warner, son of William Warner, her house lot and 158 acres of land in Ipswich.
Sarah went to live with Simon Stone in Watertown but they both returned to live in Ipswich.
In her will of 25 Mar 1663, "Sarah Stone wife of Simon Stone of Watertowne … & the relict of Richard Lumkin deceased. sometime of Boxstead in the County of Essex in England & last of all Ipswich in New England" ordered that the residue of her estate "be equally divided between ny kinsmen John Warner, Daniel Warner & Thomas Wells" & made these 3 men her executors.
Given this close connection between Sarah (Baker) (Lumpkin) Stone & the children of William Warner, & the baptism of 2 of the 3 children of William Warner at Boxted, most writers have proposed that William Warner married a sister of Sarah, but no further evidence has emerged which would confirm that this is the precise relation between the ttwo families.
Abigail's husband Deacon Thomas Wells was born 11 Dec 1605 Colchester, England. His parents were Thomas WELLS and Elizabeth KEMBALL. Thomas died 26 Oct 1666 Ipswich, Essex, Mass.
John's wife Priscilla Symonds was born 1625 in Birch Great, Essex, England. Her parents were Mark SYMONDS and Joanna [__?__]. Priscilla died 1688 Hadley, Hampshire, Mass.
John and Priscilla's children were Joseph Warner (1657), Mehitable Warner (1659), Daniel Warner (1661), Eleazar Warner (1662), and Priscilla Warner Cummings (married Thomas Cummings).
John removed from Ipswich to Brookfield in 1670, was one of three men there who took the Indian deed for the town of Brookfield, December 19, 1673, and was one of the principal inhabitants there. When the town was destroyed by the Indians in 1675 he retreated with his younger children to Hadley, Massachusetts, whither Mark Warner, an elder son, and other children had gone to settle. He was probably one of the 70 villagers who sought refuge in his brother-in-law John Ayer's tavern. For details see my post Siege of Brookfield. He probably died at the home of some of his children, 1692.
On May 17, 1692, he gave his property to his sons, Mark, Nathaniel, and Eleazar. His property included the right of two commons in and land in a Hadley and Swampfield. He also gave them 3 beds, 3 coverlets, 3 pairs of sheets, a bolster, 6 pillows, 2 brass kettles, 3 skillets, a frying pan, an iron pot, a pair tongs, an iron peale, an iron trammel, a box of iron, 2 pewter platters, a pewter basin, 2 catechisms, 2 bibles, 6 sermon books, 2 woman's coats, 2 waistcoats, a large apron, a silk handkerchief, a silk hood, a silk cap, and a hat.
This entry was posted in 13th Generation, Immigrant - England, Line - Miller and tagged Ipswich - Pioneer, The Susan and Ellen 1635. Bookmark the permalink.
I have searched the passenger lists for both the Increase and the Susan Ellin and did not find William Warner listed on either. John Warner was listed on the Increase.
landed in Virginia in 1635. Probably not a connection as the age is off by around 20 yrs?.
Yes, you probably found a different William Warner. There was very little interaction between the Viriginia and New England colonies in those days.


Prior to joining Kalypso, Mike enjoyed 29 years in a variety of assignments around the world with Procter & Gamble. He has broad experience in innovation management, sales, brand management, supply chain management, customer service and logistics in global and domestic markets. A highlight of his tenure with P&G was his six years in Latin America, where he became fluent in Spanish, an important enabler to communicate with retail customers and P&G organizations across the region. He spent his last six years as the global initiative success COE leader, where he led the organization transformation effort to improve innovation capability to deliver 4-6% annual sales growth.
He has ME & BS Chemical Engineering degrees from RPI and an MBA from Farleigh Dickinson.
Mike is an avid surfer and skier, and lives in Dana Point with his wife, Helayne; son, Zach; and daughter Mariel.


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Home Electronics News TI delivers the industry's highest voltage rating in next-generation automotive LED drivers for dashboard applications
TI delivers the industry's highest voltage rating in next-generation automotive LED drivers for dashboard applications
May 29, 2013 · by	electronics · 0
May 29th, 2013 – Texas Instruments Incorporated (TI) today introduced the next-generation AEC-Q100 qualified automotive LED drivers, feature-packed with the industry's highest voltage rating, thermal shutdown protection and optimized electromagnetic compatibility (EMC) performance. In harsh automotive environments, the electronics must endure high temperatures, high voltage transient and electromagnetic interference. It is crucial for the devices to survive such conditions while reducing electromagnetic emissions. The TLC6C598-Q1 and TLC6C5912-Q1 are monolithic, medium-voltage, low-current 8-bit/12-bit shift registers designed for use in systems that require relatively moderate load power, such as LEDs. The TLC6C598-Q1 and TLC6C5912-Q1 are designed for automotive dashboard applications, including tell-tale warning lamps, instrumentation cluster, and LED illumination and control. For more information or to order samples, visit www.ti.com/tlc6c598-q1-pr and www.ti.com/tlc6c5912-q1-pr.
Key features and benefits of the TLC6C598-Q1 and TLC6C5912-Q1:
Highest voltage rating: The TLC6C598-Q1 and TLC6C5912-Q1 have the highest rating of up to 40V on all outputs. This allows the TLC6C598-Q1 to power up to eight strings of LEDs and the TLC6C5912-Q1 to power up to twelve strings of LEDs directly connected to the automotive battery.
Thermal shutdown protection: The TLC6C598-Q1 and TLC6C5912-Q1 offer self-protection against power dissipation, which results in better long-term reliability when low- and high-temperature demands are placed on the device.
Optimized EMC performance: The TLC6C598-Q1 and TLC6C5912-Q1 have controlled and optimized rise and fall time for the outputs, reducing the electromagnetic emissions.
Tools and support:
A simulation model is available for the TLC6C598-Q1 at www.ti.com/tlc6c598-q1-model-pr and for the TLC6C5912-Q1 at www.ti.com/tlc6c5912-q1-model-pr. A reference design, schematic checklist, and application note are also available.
Availability, packaging and pricing
The TLC6C598-Q1 comes in two packages: the SOIC-D and TSSOP-PW 16-pin packages are available now for ordering at a suggested retail price of $0.50 in 2,500-unit quantities. The TLC6C5912-Q1 comes in two packages: the SOIC and TSSOP 20-pin packages are available now for ordering at a suggested retail price of $0.70 in 2,500-unit quantities.
Texas Instruments drives automotive innovation
TI's state-of-the-art semiconductor products allow manufacturers and system suppliers to deliver world-class features to the automotive market. Our extensive automotive portfolio includes analog power management, interface and signal chain solutions, along with DLP® displays, ADAS and infotainment processors, Hercules™ TMS570 safety microcontrollers and wireless connectivity solutions. TI offers SafeTI™ devices designed to facilitate OEMs' compliance with the requirements of ISO 26262, as well as parts specifically designated as compliant with the AEC-Q100 and TS16949 standards, all with excellent product documentation. Click here to learn more.
Find out more about TI's automotive and transportation portfolio by visiting the links below:
TI has a complete automotive cluster tell-tale LED driver portfolio. In addition to the cost-efficient, non-constant current TLC6C598-Q1 and TLC6C5912-Q1, TI's LED portfolio includes constant current LED drivers with built-in diagnostics including TLC5916-Q1, TLC5917-Q1, TLC5926-Q1, TLC5927-Q1 and the TLC5941-Q1.
View TI's complete automotive and transportation portfolio: www.ti.com/automotive-pr.
Download TI's Automotive and Transportation Selection Guide: www.ti.com/automotiveguide-pr.
Download TI's Infotainment Guide: www.ti.com/infotainmentguide-pr.
Join the TI E2ETM Automotive Community: www.ti.com/e2eautomotive-pr.
Keep up with the latest automotive happenings at TI: www.ti.com/behindthewheel-pr.
Filed in: Electronics News
CyberOptics Unveils WaferSense® Auto Resistance Sensor™ (ARS) at SEMICON Korea
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Microchip Announces Industry's First Space-Qualified COTS-Based Radiation-Tolerant Ethernet Transceiver and Embedded Microcontroller


At the zoo, this lovely young lady saw me taking pictures of my kids and asked me to take her picture. Teenage years are typically very awkward and uncomfortable so I had to chuckle when I saw this posted on Kerlice's (pronounced Kerleese) Facebook page. I LOVE MYSELF. I DON'T kNOW 'BOUT U BUT I FEEL I IS IT. Clearly Kerlice doesn't suffer the typical teenage angst about her self image. Good for her!
I prefer the photo in color. The B&W photo makes her look too dark and masks some of her features.
Such a simple face, and perfectly symmetrical as well.


Suzy Badaracco is a toxicologist, chef, and registered dietitian. She holds a Bachelors of Science degree in Criminalistics, an Associates degree in Culinary Arts, and a Masters of Science degree in Human Nutrition. Suzy has worked as an analytical chemist, corporate chef, nutrition specialist, trainer, knowledge manager and trends forecaster for food industry clients since 1992. Suzy has been trained in military intelligence, chaos theory, and predictive analysis techniques used by both corporate and government bodies and has been practicing trends intelligence and predictive forecasting for more than 14 years. Using these techniques she has been able to successfully predict and profile food, flavor, consumer, packaging, and health trends in the United States and research, technology, and government trends internationally for all areas of the food industry.


Carry up to 20kg (44lbs) of tools and materials with this clever bag carrying clip. It's a great way to move about your home or garden without having your hands full. And even though it grips tight to the material of your bag, it won't tear or pull thanks to its unique 'no tear' technology.
The U-Can Universal Bag Carrying Clip doesn't just hold all the things you need to get the job done properly. It seals your bag too, so it's spill proof and airtight.
To use, just bend back the tab and open the jaws, then snap closed for a firm, permanent grip. It's in the bag!


AVENGERS #1 (1963) UNRESTORED S.S. CGC GD/VG 3.0 OW PAGES STAN LEE SIGNED!!
The Avengers #1 from 1963. The book has been certified by CGC as UNRESTORED GD/VG 3.0 with off-white pages. The holder is like new and the serial number is 1278027008. "SIGNED BY STAN LEE ON 9/26/14." All sales are final on CGC graded books. Thanks for looking!


text:
Sminge Kloster lå syd for Sminge Sø. Det  blev grundlagt 1165 af cisterciensermunke fra Vitskøl Kloster.  I 1164 skænkede biskop Eskil fra Århus en grund til et cistercienserkloster i Sabro til abbed Henrik fra Vitskøl Kloster. Abbeden fandt ikke beligenheden særlig god, så biskoppen fandt en grund i Sminge i stedet. Klosteret eksisterede dog kun kort tid, da dets jordtilliggende var for lille til at danne grundlag for en klosterøkonomi, og allerede  i 1166 flyttede munkene videre til Veng Kloster, for til sidst i 1172 at ende ved Mossø, hvor de opførte Øm Kloster.

Kilder
 Cistercienserklosteret Øm Kloster ved Mossø  Danmarks Kulturarvs Forening.
 Sminge Kirke (nedbrudt) hos danmarkskirker.natmus.dk (Danmarks Kirker, Nationalmuseet)

Klostre i Danmark
Bygninger, konstruktioner og anlæg i Silkeborg Kommune

redpajama_set_name: RedPajamaWikipedia


You are visiting the placeholder page for Charles Richardson. This page is here because someone used our placeholder utility to look for Charles Richardson. We created this page automatically in hopes Charles Richardson would find it. If you are not Charles Richardson, but are an alumni of Sheboygan Falls High School, register on this site for free now.


text:
UPDATE: San Jose Faces Alarming Spike in Fatal Traffic AccidentsPolice in the South Bay on Wednesday were still investigating a double-fatal accident Tuesday night that raised the already high traffic death count for 2022 in San Jose.
UPDATE: FBI Investigating Possible Explosive Device Outside Oakland Courthouse; Evacuations OrderedAuthorities were investigating a possible explosive device near a federal building in downtown Oakland Wednesday, forcing evacuations and street closures that afternoon.
CBS SF Talks To Hard-Rock Legend Alice CooperOne of the most influential hard-rock acts of the 1970s still actively touring and recording, Alice Cooper talks about recent activity ahead of bringing his spectacular stage show to the Warfield on October 26.
Alice Cooper Talks Rock Festivals, Reunions And 'Bizarre' Presidential CandidatesOne of the most influential hard-rock acts of the 1970s still actively touring and recording, Alice Cooper talks about working on new songs with the surviving members of his original band and his upcoming headlining festival appearance at Psycho Las Vegas.
Joe Perry To Rejoin 'Hollywood Vampires' In SonomaAlice Cooper reports that guitarist Joe Perry will rejoin the band this Friday night.
Hollywood Vampires' Tour Will Continue, Perry's Status UncertainThe show goes on. Alice Cooper took to to social media this afternoon to assure fans the Hollywood Vampies' tour would continue...
Aerosmith's Joe Perry Hospitalized After Becoming Ill At NY ShowPerry became ill around 9:30 p.m. Sunday while performing with Johnny Depp and Alice Cooper in his side band, the Hollywood Vampires, at Ford Amphitheater in Brooklyn's Coney Island...
Hollywood Vampires Announce U.S. Tour Dates With Saratoga StopSupergroup composed of Alice Cooper, Johnny Depp and Joe Perry, have announced a run of U.S. tour dates...
My Favorite Course: Alice CooperLegendary shock-rocker Alice Cooper talks about his favorite golf courses and what turned him into a golf fanatic.
Summer Songs: 10 Classic Tracks To Heat Up The SeasonWhat's summer without a soundtrack? Here are some classics to keep you groovin' when the temperature rises.
Summer Tour Guide - From The Allman Brothers to ZZ Top Summer's here, and the time is right for dancing in the seats. Check out this season's hottest outdoor concert tours.
5:30 PMKPIX 5 News @ 5:30pm


text:
Q: How can I ensure input is in the form #.## I need to error check to ensure that user input has two decimal places.
How can I achieve this?
I ended up doing something like this:
 if len(input) > 3:
      if input[-3] == ".":
           #then the validation of the varriable

A: You seem to want nothing but one number, decimal, and two numbers:
import re
s = '3.45'
if re.match("^\d{1}\.\d{2}$", s):
    print(s)
else:
    print('No match')

\d* matches no numbers or as many as you want. \d+ matches one number or as many as you want. \d{2} matches two numbers. ^ starts at the beginning, and $ ends at the end.
In Python 2x raw_input returns a string, and in Python 3x input does.


text:
<?xml version="1.0" encoding="utf-8"?>
<resources>
    <!-- From: file:/D:/AndroidStudioProjects/Highlight/highlight/src/main/res/values/strings.xml -->
    <eat-comment/>
    <string name="app_name">highlight</string>
</resources>

redpajama_set_name: RedPajamaGithub


text:
Ashes Series Selection Dilemma: Fitting 14 into 11
Australian selectors have one heck of a job picking 11 blokes to face England at Sophia Gardens. Contention rages over the middle order and the bowling attack but unlike 2009 or 2013 these are good problems; at least 14 guys make a good case for the Cardiff Test.
An almost leisurely two nil victory in the Caribbean confirmed two theories and uncovered another; Steve Smith is becoming one of the best batsman Australia has produced in over a decade, Australia's fast bowling is lethal and Adam Voges is a capable dark horse. Perhaps a fourth note should be added, Shane Watson continues to pour on the match-winning 25s.
The Aussies begin with two four day tour matches and the first starts on 25 June at Kent followed by Essex at Chelmsford. This gives the players and selectors an opportunity to perform and assess.
Here's a wrap of the Aussie touring party.
Certainty at the top
Chris Rogers missed two Tests in the Caribbean due to concussion but he surely returns to partner David Warner.
Steve Smith is Australia's tenth number 3 since 2011 and – at 26 with an average of 56 and scores of 97, 162*, 52*, 133, 28, 192, 14, 117, 71, 25, 5*, 199 & 54* in his last 13 innings – could be the last number 3 Australia will need until about 2025.
Michael Clarke is determined to be the first captain to win in England since Steve Waugh in 2001.
The middle candidates
Shaun Marsh scored a ton on debut in 2011. Couldn't get off the mark in several subsequent innings and was dropped. Came back in 2014 and has scores of 32, 17, 32, 99, 73 & 1 at number 5 against India and 19, 13*, 11 & 69 against West Indies filling at opener.
Adam Voges plundered a ton on debut against the West Indies. Voges' selection baffled punters who'd prefer a younger talent but at 35 and with 11000 First Class runs at 46, Voges adds steel to Australia's squad. After 14 years without a win in England this is not a series about blooding talent.
Mitchell Marsh was promising with the bat in the Tests he played against Pakistan and India and is unspectacular, although talented, with the ball.
Shane Watson… um. There's still a strong chance he'll play a key role in this series. He's a great slips fielder. Every team needs one!
Wicket-keepers
Cricket Froth was convinced Brad Haddin would retire at the end of the summer. But at 37 Hads is keen as mustard to win a series in England. His presence is a huge asset for Australia. Opponents hate him; he brings the needle to this Aussie team (along with Watson from behind the stumps) and won't be moved an inch by a combative English media or parochial home crowds. Peter Neville is Haddin's capable back-up.
The bowlers
There's only one thing as certain as the force of gravity on planet earth; Ryan Harris will play every single Test match in England if he is fit.
Splitting the rest is probably the most difficult task for selectors. Mitch Johnson murdered England last time and is in solid form. Mitch Starc swung the Duke a mile in the Caribbean and was lethal in the world cup and Josh Hazlewood has looked the part since hitting the Test scene. All these blokes bowl between 140-150kph and then there's Peter Siddle, a proven workhorse who's dropped to 5 in the pecking order.
In one sense the ECB could be expected to kill the local pitches to negate this ferocious attack, but England does not have a frontline spinner. Whatever is done to tame pitches for Australia's fast bowlers will have equal effect on the hosts.
Nathan Lyon will be needed as Australia seems reluctant to play four fast bowlers. Victorian leg spinner Fawad Ahmed is the 17th man on tour and could be a trump card if a real turning pitch shows up.
In a strange video coming out of Dominica in the West Indies the Aussies revealed that pickle juice is used widely by players as a highly regarded cure for muscle cramps. See the Cricket Australia video here: http://www.cricket.com.au/video/chris-rogers-video-blog-pickle-juice-dehydration-west-indies-test-series-bupa/2015-06-19
Posted in who won toss in Cardiff and tagged 2015 Ashes Series, Ashes 2015, Aussie selectors, Australia, Cardiff Test, pace attack, pickle juice cures cramp, Shane Watson, Steve Smith best batsman, Steve Smith number 1 batsman, The Ashes on June 17, 2015 by PT White. 1 Comment
← Spiced Carib Run: uncertain 11s and the tenth anniversary of 'that series'
Moving Day: Shane Watson versus England (and the Australian public) →
Pingback: England Cooked: Bell's Lyth hangs in the Ballance | For the Purists Who Love Test Match Cricket


text:
Home Gear Shoei Neotec Motorcycle Helmet Review
Shoei Neotec Motorcycle Helmet Review
Greg Drevenstedt
Helmets wrap snugly around our heads, with the interior conforming to the contours of our noggin and the chin strap cinched around our lower jaw, keeping the helmet securely in place. Some helmets do this with tolerable comfort; others do this poorly, resulting in achy heads, sore ears and chafed necks. And then there are helmets that are genuinely comfortable, so much so that you look forward to putting them on, to having your head wrapped in a satisfying embrace. The new Shoei Neotec is that sort of helmet.
An improvement upon the Multitec flip-up helmet that has been in Shoei's lineup since 2006 (and is still available), the Neotec is said to be more aerodynamic, quieter, better ventilated and equipped with new features. The shell is made using Shoei's proprietary Advanced Integrated Matrix (AIM) construction, which comprises three layers: fiber-reinforced matrix, compound structure (layers of organic and glass fibers) and synthetic resin. Shoei says AIM offers "ideal dampening of impacts, good elasticity, light weight, and enormously high strength and resistance to penetration." Wind tunnel testing led Shoei's engineers to incorporate a dual-ridge face shield bead and the chinbar's "Vortex Generator" lip, and to eliminate the face shield lock for better airflow and less noise. Like the RF-1100, the Neotec's shell has an integrated rear spoiler for improved stability at speed. The Neotec's six head sizes (XS-XXL) are covered by three shell sizes, resulting in a closer fit between the rider's head and the impact-absorbing EPS liner rather than using too much or too little comfort padding to make up the difference.
Shoei Neotec Helmet
Wind tunnel testing also informed the design of the Neotec's ventilation system, which has intake vents on the chinbar and crown and an exhaust vent on the back that takes advantage of negative pressure to create suction. Compared to the Multitec, the chin vents are smaller but the crown vents are larger, and they are set within a pronounced air scoop that draws in an impressive blast of refreshing air. The design makes sense because the Neotec will most often be worn by touring riders on motorcycles with large windscreens, where airflow is most consistent at the top of the rider's helmet. Ventilation is further enhanced by air tunnels within the Neotec's dual-layer, multi-density EPS liner.
The Neotec has Shoei's QR-N quick-release base plate that facilitates effortless shield changes and has a patented, spring-loaded design that ensures a tight, waterproof seal. A wider, taller eye port necessitated the new CNS-1 face shield, and the QSV-1 retractable sun visor is a first for Shoei. Both the shield and visor are 3D injection-molded and block 99 percent of UV rays, and the face shield comes with a Pinlock anti-fog insert.
Everything about the Neotec looks and feels premium, from the shape of the shell to the plushness of the removable, washable interior (multi-layer cheek pads are available in different thicknesses), from the ease-of-use of the vents, sun visor and chinbar to the stainless steel components in the 360-degree Pivot Locking System. After weeks of use, the Neotec has proven to be one of the most comfortable, quietest flip-up helmets I've ever worn, on par with many high-end full-face helmets. And its many improvements over the Multitec have added only 1.6 ounces to its weight (64.8 ounces).
The Shoei Neotec helmet is available in sizes XS-XXL in solid ($648.99) and metallic ($662.99) colors and comes with a five-year limited warranty.
(This Gearlab article was printed in the August 2012 issue of Rider.)
Greg Drevenstedt - January 18, 2021


NEWPORT, Maine (NEWS CENTER) — This week's Maine Education Association Inspiring Educator is Lisa Neal, a theater arts teacher at Nokomis Regional High School in Newport.
"Because this teaches so much more than content," Neal said. "It teaches self-confidence, problem-solving on the spot, teaches them composure. There's just so many facets to the theater arts to teach students"
Nokomis Regional High School is part of RSU 19.


Job Description/Duties: Check in users of Patriot Hall. Monitor students and users of Patriot Hall. Go through Patriot Hall to monitor for cleanliness and safety. May need to check equipment in and out. Understand and reinforce building/facility policies and procedures. Must be able to lift 30 pounds and walk throughout the building.


text:
l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes
K.-C. Yang, Chang Chin Wu, Wei Yu Chen, S. Sumi, Teng Le Huang
School of Dental Technology
Research Center for Biomedical Devices
Graduate Institute of Biomedical Materials and Tissue Engineering
Intra-articular injection of hyaluronic acid (HA) has been widely accepted for the treatment of osteoarthritis (OA) in early stage. l-Glutathione (GSH), an antioxidant, has an anti-inflammatory effect on protecting cells from reactive oxygen species and reactive nitrogen species (ROS/RNS). In this study, the therapeutic effects of HA (0.1%) supplemented with GSH (0, 5, 10, and 20% in weight ratios to HA) on human fibroblast-like synoviocytes (FLSs) were evaluated. The results showed that cell morphology and glycosaminoglycan production of FLSs were not changed under treatments. However, the addition of HA + 20% GSH significantly decreased cell survival (p <0.001) relative to other groups. Relative to un-stimulated FLSs, interleukin-1 beta (IL-1β) stimulation significantly decreased the total antioxidant capacity (p <0.001) of cells. The antioxidant capacity was restored and the intracellular ROS/RNS was decreased in HA or HA + GSH-treated FLSs. Real-time PCR analysis revealed the mRNA levels of IL-1β, tumor necrosis factor-alpha, and matrix metalloproteinase-3 were down-regulated significantly (all p <0.05) when FLSs cultured in HA or HA + GSH. IL-6 mRNA expressions were down-regulated significantly in HA and HA + 5% GSH groups (both p <0.05) but up-regulated when HA supplemented with 10% and 20% GSH (both p <0.01). In addition, the protein levels of IL-1β were further decreased with significant differences (both p <0.05) in the HA + 10% GSH and HA + 20% GSH groups when compared to FLSs cultured in normal medium. In conclusion, HA supplemented with GSH improves antioxidant capacity and modulates pro-inflammatory cytokines expressions in FLSs. GSH has the potential to augment the effect of viscosupplementation using HA on OA patients. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2071–2079, 2016. © 2016 Wiley Periodicals, Inc.
Journal of Biomedical Materials Research - Part A
https://doi.org/10.1002/jbm.a.35729
fibroblast-like synoviocyte
Glutathiones
Intra-articular injection
Matrix-metalloproteinase-3
Pro-inflammatory cytokines
Synoviocytes
Total antioxidant capacity
Tumor necrosis factor alpha
10.1002/jbm.a.35729
https://www.scopus.com/inward/record.uri?eid=2-s2.0-84979081059&partnerID=40&md5=e96494c5c81260e9e57b888ae3d791af
Dive into the research topics of 'l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes'. Together they form a unique fingerprint.
Glutathione Engineering & Materials Science 100%
Hyaluronic acid Engineering & Materials Science 93%
Cytokines Engineering & Materials Science 91%
Fibroblasts Engineering & Materials Science 79%
Antioxidants Engineering & Materials Science 73%
Hyaluronic Acid Chemical Compounds 62%
Reactive oxygen species Engineering & Materials Science 12%
Messenger RNA Engineering & Materials Science 10%
Yang, K-C., Wu, C. C., Chen, W. Y., Sumi, S., & Huang, T. L. (2016). l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes. Journal of Biomedical Materials Research - Part A, 104(8), 2071-2079. https://doi.org/10.1002/jbm.a.35729
l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes. / Yang, K.-C.; Wu, Chang Chin; Chen, Wei Yu; Sumi, S.; Huang, Teng Le.
In: Journal of Biomedical Materials Research - Part A, Vol. 104, No. 8, 2016, p. 2071-2079.
Yang, K-C, Wu, CC, Chen, WY, Sumi, S & Huang, TL 2016, 'l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes', Journal of Biomedical Materials Research - Part A, vol. 104, no. 8, pp. 2071-2079. https://doi.org/10.1002/jbm.a.35729
Yang K-C, Wu CC, Chen WY, Sumi S, Huang TL. l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes. Journal of Biomedical Materials Research - Part A. 2016;104(8):2071-2079. https://doi.org/10.1002/jbm.a.35729
Yang, K.-C. ; Wu, Chang Chin ; Chen, Wei Yu ; Sumi, S. ; Huang, Teng Le. / l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes. In: Journal of Biomedical Materials Research - Part A. 2016 ; Vol. 104, No. 8. pp. 2071-2079.
@article{abfe41c8f8474f0997c365db55feaebe,
title = "l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes",
abstract = "Intra-articular injection of hyaluronic acid (HA) has been widely accepted for the treatment of osteoarthritis (OA) in early stage. l-Glutathione (GSH), an antioxidant, has an anti-inflammatory effect on protecting cells from reactive oxygen species and reactive nitrogen species (ROS/RNS). In this study, the therapeutic effects of HA (0.1%) supplemented with GSH (0, 5, 10, and 20% in weight ratios to HA) on human fibroblast-like synoviocytes (FLSs) were evaluated. The results showed that cell morphology and glycosaminoglycan production of FLSs were not changed under treatments. However, the addition of HA + 20% GSH significantly decreased cell survival (p <0.001) relative to other groups. Relative to un-stimulated FLSs, interleukin-1 beta (IL-1β) stimulation significantly decreased the total antioxidant capacity (p <0.001) of cells. The antioxidant capacity was restored and the intracellular ROS/RNS was decreased in HA or HA + GSH-treated FLSs. Real-time PCR analysis revealed the mRNA levels of IL-1β, tumor necrosis factor-alpha, and matrix metalloproteinase-3 were down-regulated significantly (all p <0.05) when FLSs cultured in HA or HA + GSH. IL-6 mRNA expressions were down-regulated significantly in HA and HA + 5% GSH groups (both p <0.05) but up-regulated when HA supplemented with 10% and 20% GSH (both p <0.01). In addition, the protein levels of IL-1β were further decreased with significant differences (both p <0.05) in the HA + 10% GSH and HA + 20% GSH groups when compared to FLSs cultured in normal medium. In conclusion, HA supplemented with GSH improves antioxidant capacity and modulates pro-inflammatory cytokines expressions in FLSs. GSH has the potential to augment the effect of viscosupplementation using HA on OA patients. {\textcopyright} 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2071–2079, 2016. {\textcopyright} 2016 Wiley Periodicals, Inc.",
keywords = "fibroblast-like synoviocyte, glutathione, hyaluronic acid, osteoarthritis, Antioxidants, Cell culture, Cells, Cytology, Enzyme activity, Fibroblasts, Organic acids, Peptides, Polymerase chain reaction, Tissue, Glutathiones, Intra-articular injection, Matrix-metalloproteinase-3, Pro-inflammatory cytokines, Synoviocytes, Total antioxidant capacity, Tumor necrosis factor alpha, Hyaluronic acid",
author = "K.-C. Yang and Wu, {Chang Chin} and Chen, {Wei Yu} and S. Sumi and Huang, {Teng Le}",
note = "Export Date: 24 August 2016 CODEN: JBMRC 通訊地址: Huang, T.-L.; Department of Sports Medicine, College of Health Care, China Medical UniversityTaiwan; 電子郵件: bone101bone@yahoo.com.tw 參考文獻: Balazs, E.A., Denlinger, J., Viscosupplementation: A new concept in the treatment of osteoarthritis (1993) J Rheumatol, 20, pp. 3-9; Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., M{\"u}llner, M., Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis (2005) CMAJ, 172, pp. 1039-1043; Printz, J.O., Lee, J., Knesek, M., Urquhart, A.G., Conflict of interest in the assessment of hyaluronic acid injections for osteoarthritis of the knee: An updated systematic review (2013) J Arthroplasty, 2814, p. 33. , MD; Fam, H., Bryant, J.T., Kontopoulou, M., Rheological properties of synovial fluids (2007) Biorheology, 44, pp. 59-74; Akmal, M., Singh, A., Anand, A., Kesani, A., Aslam, N., Goodship, A., Bentley, G., The effects of hyaluronic acid on articular chondrocytes (2005) J Bone Joint Surg Br, 87, pp. 1143-1149; Lee, P.B., Kim, Y.C., Lim, Y.J., Lee, C.J., Sim, W.S., Ha, C.W., Bin, S.I., Lee, S.C., Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients: open-label, randomized, multicentre clinical trial (2006) J Int Med Res, 34, pp. 77-87; Kirchner, M., Marshall, D., A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee (2006) Osteoarthritis Cartilage, 14, pp. 154-162; Calmbach, W.L., Hutchens, M., Evaluation of patients presenting with knee pain: Part II. Differential diagnosis (2003) Am Fam Phys, 68, pp. 917-922; Zwerina, J., Hayer, S., Tohidast-Akrad, M., Bergmeister, H., Redlich, K., Feige, U., Dunstan, C., Schett, G., Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction (2004) Arthritis Rheum, 5020, p. 290; Kim, J., Xu, M., Xo, R., Mates, A., Wilson, G.L., Pearsall, A.W., 4th, Grishko, V., Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes (2010) Osteoarthritis Cartilage, 18, pp. 424-432; Henrotin, Y., Kurz, B., Aigner, T., Oxygen and reactive oxygen species in cartilage degradation: friends or foes? (2005) Osteoarthritis Cartilage, 13, pp. 643-654; Ostalowska, A., Birkner, E., Wiecha, M., Kasperczyk, S., Kasperczyk, A., Kapolka, D., Zon-Giebel, A., Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint (2006) Osteoarthritis Cartilage, 14, pp. 139-145; Bubici, C., Papa, S., Dean, K., Franzoso, G., Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance (2006) Oncogene, 25, pp. 6731-6748; Hiramitsu, T., Yasuda, T., Ito, H., Shimizu, M., Julovi, S.M., Kakinuma, T., Akiyoshi, M., Nakamura, T., Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38. 26 (2006) Rheumatology (Oxford), 45, pp. 824-832; Westacott, C.I., Barakat, A.F., Wood, L., Perry, M.J., Neison, P., Bisbinas, I., Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritis (2000) Osteoarthritis Cartilage, 8, pp. 213-221; Regan, E.A., Bowler, R.P., Crapo, J.D., Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury (2008) Osteoarthritis Cartilage, 16, pp. 515-521; Habuchi, O., Miyachi, T., Kaigawa, S., Nakashima, S., Fujiwara, C., Hisada, M., Effects of glutathione depletion on the synthesis of proteoglycan and collagen in cultured chondrocytes (1991) Biochim Biophys Acta, 1093, pp. 153-161; Ostalowska, A., Birkner, E., Wiecha, M., Kasperczyk, S., Kasperczyk, A., Kapolka, D., Zon-Giebel, A., Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint Osteoarthritis Cartilage, 14, pp. 139-145; Afonso, V., Champy, R., Mitrovic, D., Collin, P., Lomri, A., Reactive oxygen species and superoxide dismutases: Role in joint diseases (2007) Joint Bone Spine, 32, pp. 324-329; Ohata, J., Zvaifler, N.J., Nishio, M., Boyle, D.L., Kalled, S.L., Carson, D.A., Kipps, T.J., Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines (2005) J Immunol, 174, pp. 864-870; Bartok, B., Firestein, G.S., Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis (2010) Immunol Rev, 233, pp. 233-255; Carlo, M.D., Jr., Loeser, R.F., Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels (2003) Arthritis Rheum, 48, pp. 3419-3430; Greenberg, D.D., Stoker, A., Kane, S., Cockrell, M., Cook, J.L., Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis (2006) Osteoarthritis Cartilage, 14, pp. 814-822; Steenvoorden, M.M., Huizinga, T.W., Verzijl, N., Bank, R.A., Ronday, H.K., Luning, H.A., Lafeber, F.P., DeGroot, J., Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes (2006) Arthritis Rheum, 54, pp. 253-263; Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M., Amiel, D., Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model (2001) J Orthop Res, 19, pp. 500-503; Gregg, A.J., Fortier, L.A., Mohammed, H.O., Mayr, K.G., Miller, B.J., Haupt, J.L., Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes (2006) Am J Vet Res, 67, pp. 957-962; Lin, W.Y., Sadhasivam, S., Lin, F.H., The dose dependent effects of betulin on porcine chondrocytes (2009) Process Biochem, 44, pp. 678-684; Chen, P.Y., Hsu, C.C., Yang, K.C., Wu, C.C., Wang, C.L., The effects of negative pressure treatment on the extracellular matrix gene expression and protein production of fibroblasts (2015) Process Biochem, 50, pp. 1662-1668; Yang, S.H., Lin, C.C., Hu, M.H., Shih, T.T., Sun, Y.H., Lin, F.H., Influence of age-related degeneration on regenerative potential of human nucleus pulposus cells (2010) J Orthop Res, 28, pp. 379-383; Chen, M.P., Yang, S.H., Chou, C.H., Yang, K.C., Wu, C.C., Cheng, Y.H., Lin, F.H., The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: Inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level (2010) Inflamm Res, 59, pp. 587-595; Yang, K.C., Chen, H.T., Wu, C.C., Lian, Y.J., Chen, L.L., Sumi, S., Huang, T.L.L., Glutamine regulates the expression of matrix proteins, pro-inflammatory cytokines and catabolic enzymes in IL-1β-stimulated human chondrocytes (2016) Process Biochem, 51, pp. 414-421; Mathy-Hartert, M., Hogge, L., Sanchez, C., Deby-Dupont, G., Crielaard, J.M., Henrotin, Y., Interleukin-1beta and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: A possible explanation for oxidative stress generation (2008) Osteoarthritis Cartilage, 1649, p. 763; Wang, C.T., Lin, Y.T., Chiang, B.L., Lin, Y.H., Hou, S.M., High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis (2006) Osteoarthritis Cartilage, 50, pp. 1237-1247; Kataoka, Y., Ariyoshi, W., Okinaga, T., Kaneuji, T., Mitsugi, S., Takahashi, T., Nishihara, T., Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid (2013) Biochem Biophys Res Commun, 432, pp. 580-585; Sakkas, L.I., Scanzello, C., Johanson, N., Burkholder, J., Mitra, A., Salgame, P., Katsetos, C.D., Platsoucas, C.D., T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis (1998) Clin Diagn Lab Immunol, 5, pp. 430-437; Moos, V., Fickert, S., Muller, B., Weber, U., Sieper, J., Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage (1999) J Rheumatol, 26, pp. 870-879; Martel-Pelletier, J., Pathophysiology of osteoarthritis (2004) Osteoarthritis Cartilage, 12, pp. S31-S33; Chakraborti, S., Mandal, M., Das, S., Mandal, A., Chakraborti, T., Regulation of matrix metalloproteinases: An overview (2003) Mol Cell Biochem, 253, pp. 269-285; Stannus, O., Jones, G., Cicuttini, F., Parameswaran, V., Quinn, S., Burgess, J., Ding, C., Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults (2010) Osteoarthritis Cartilage, 18, pp. 1441-1447; Doss, F., Menard, J., Hauschild, M., Kreutzer, H.J., Mittlmeier, T., M{\"u}ller-Steinhardt, M., M{\"u}ller, B., Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells (2007) Scand J Rheumatol, 36, pp. 136-139; van de Loo, F.A., Kuiper, S., van Enckevort, F.H., Arntz, O.J., van den Berg, W.B., Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice (1997) Am J Pathol, 151, pp. 177-191; de Hooge, A.S., van de Loo, F.A., Bennink, M.B., Arntz, O.J., de Hooge, P., van den Berg, W.B., Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging (2005) Osteoarthritis Cartilage, 13, pp. 66-73; Silacci, P., Dayer, J.M., Desgeorges, A., Peter, R., Manueddu, C., Guerne, P.A., Interleukin (IL)−6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity (1998) J Biol Chem, 273, p. 13625",
doi = "10.1002/jbm.a.35729",
journal = "Journal of Biomedical Materials Research - Part B Applied Biomaterials",
T1 - l-Glutathione enhances antioxidant capacity of hyaluronic acid and modulates expression of pro-inflammatory cytokines in human fibroblast-like synoviocytes
AU - Yang, K.-C.
AU - Wu, Chang Chin
AU - Chen, Wei Yu
AU - Sumi, S.
AU - Huang, Teng Le
N1 - Export Date: 24 August 2016 CODEN: JBMRC 通訊地址: Huang, T.-L.; Department of Sports Medicine, College of Health Care, China Medical UniversityTaiwan; 電子郵件: bone101bone@yahoo.com.tw 參考文獻: Balazs, E.A., Denlinger, J., Viscosupplementation: A new concept in the treatment of osteoarthritis (1993) J Rheumatol, 20, pp. 3-9; Arrich, J., Piribauer, F., Mad, P., Schmid, D., Klaushofer, K., Müllner, M., Intra-articular hyaluronic acid for the treatment of osteoarthritis of the knee: systematic review and meta-analysis (2005) CMAJ, 172, pp. 1039-1043; Printz, J.O., Lee, J., Knesek, M., Urquhart, A.G., Conflict of interest in the assessment of hyaluronic acid injections for osteoarthritis of the knee: An updated systematic review (2013) J Arthroplasty, 2814, p. 33. , MD; Fam, H., Bryant, J.T., Kontopoulou, M., Rheological properties of synovial fluids (2007) Biorheology, 44, pp. 59-74; Akmal, M., Singh, A., Anand, A., Kesani, A., Aslam, N., Goodship, A., Bentley, G., The effects of hyaluronic acid on articular chondrocytes (2005) J Bone Joint Surg Br, 87, pp. 1143-1149; Lee, P.B., Kim, Y.C., Lim, Y.J., Lee, C.J., Sim, W.S., Ha, C.W., Bin, S.I., Lee, S.C., Comparison between high and low molecular weight hyaluronates in knee osteoarthritis patients: open-label, randomized, multicentre clinical trial (2006) J Int Med Res, 34, pp. 77-87; Kirchner, M., Marshall, D., A double-blind randomized controlled trial comparing alternate forms of high molecular weight hyaluronan for the treatment of osteoarthritis of the knee (2006) Osteoarthritis Cartilage, 14, pp. 154-162; Calmbach, W.L., Hutchens, M., Evaluation of patients presenting with knee pain: Part II. Differential diagnosis (2003) Am Fam Phys, 68, pp. 917-922; Zwerina, J., Hayer, S., Tohidast-Akrad, M., Bergmeister, H., Redlich, K., Feige, U., Dunstan, C., Schett, G., Single and combined inhibition of tumor necrosis factor, interleukin-1, and RANKL pathways in tumor necrosis factor-induced arthritis: Effects on synovial inflammation, bone erosion, and cartilage destruction (2004) Arthritis Rheum, 5020, p. 290; Kim, J., Xu, M., Xo, R., Mates, A., Wilson, G.L., Pearsall, A.W., 4th, Grishko, V., Mitochondrial DNA damage is involved in apoptosis caused by pro-inflammatory cytokines in human OA chondrocytes (2010) Osteoarthritis Cartilage, 18, pp. 424-432; Henrotin, Y., Kurz, B., Aigner, T., Oxygen and reactive oxygen species in cartilage degradation: friends or foes? (2005) Osteoarthritis Cartilage, 13, pp. 643-654; Ostalowska, A., Birkner, E., Wiecha, M., Kasperczyk, S., Kasperczyk, A., Kapolka, D., Zon-Giebel, A., Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint (2006) Osteoarthritis Cartilage, 14, pp. 139-145; Bubici, C., Papa, S., Dean, K., Franzoso, G., Mutual cross-talk between reactive oxygen species and nuclear factor-kappa B: molecular basis and biological significance (2006) Oncogene, 25, pp. 6731-6748; Hiramitsu, T., Yasuda, T., Ito, H., Shimizu, M., Julovi, S.M., Kakinuma, T., Akiyoshi, M., Nakamura, T., Intercellular adhesion molecule-1 mediates the inhibitory effects of hyaluronan on interleukin-1beta-induced matrix metalloproteinase production in rheumatoid synovial fibroblasts via down-regulation of NF-kappaB and p38. 26 (2006) Rheumatology (Oxford), 45, pp. 824-832; Westacott, C.I., Barakat, A.F., Wood, L., Perry, M.J., Neison, P., Bisbinas, I., Tumor necrosis factor alpha can contribute to focal loss of cartilage in osteoarthritis (2000) Osteoarthritis Cartilage, 8, pp. 213-221; Regan, E.A., Bowler, R.P., Crapo, J.D., Joint fluid antioxidants are decreased in osteoarthritic joints compared to joints with macroscopically intact cartilage and subacute injury (2008) Osteoarthritis Cartilage, 16, pp. 515-521; Habuchi, O., Miyachi, T., Kaigawa, S., Nakashima, S., Fujiwara, C., Hisada, M., Effects of glutathione depletion on the synthesis of proteoglycan and collagen in cultured chondrocytes (1991) Biochim Biophys Acta, 1093, pp. 153-161; Ostalowska, A., Birkner, E., Wiecha, M., Kasperczyk, S., Kasperczyk, A., Kapolka, D., Zon-Giebel, A., Lipid peroxidation and antioxidant enzymes in synovial fluid of patients with primary and secondary osteoarthritis of the knee joint Osteoarthritis Cartilage, 14, pp. 139-145; Afonso, V., Champy, R., Mitrovic, D., Collin, P., Lomri, A., Reactive oxygen species and superoxide dismutases: Role in joint diseases (2007) Joint Bone Spine, 32, pp. 324-329; Ohata, J., Zvaifler, N.J., Nishio, M., Boyle, D.L., Kalled, S.L., Carson, D.A., Kipps, T.J., Fibroblast-like synoviocytes of mesenchymal origin express functional B cell-activating factor of the TNF family in response to proinflammatory cytokines (2005) J Immunol, 174, pp. 864-870; Bartok, B., Firestein, G.S., Fibroblast-like synoviocytes: Key effector cells in rheumatoid arthritis (2010) Immunol Rev, 233, pp. 233-255; Carlo, M.D., Jr., Loeser, R.F., Increased oxidative stress with aging reduces chondrocyte survival: correlation with intracellular glutathione levels (2003) Arthritis Rheum, 48, pp. 3419-3430; Greenberg, D.D., Stoker, A., Kane, S., Cockrell, M., Cook, J.L., Biochemical effects of two different hyaluronic acid products in a co-culture model of osteoarthritis (2006) Osteoarthritis Cartilage, 14, pp. 814-822; Steenvoorden, M.M., Huizinga, T.W., Verzijl, N., Bank, R.A., Ronday, H.K., Luning, H.A., Lafeber, F.P., DeGroot, J., Activation of receptor for advanced glycation end products in osteoarthritis leads to increased stimulation of chondrocytes and synoviocytes (2006) Arthritis Rheum, 54, pp. 253-263; Takahashi, K., Hashimoto, S., Kubo, T., Hirasawa, Y., Lotz, M., Amiel, D., Hyaluronan suppressed nitric oxide production in the meniscus and synovium of rabbit osteoarthritis model (2001) J Orthop Res, 19, pp. 500-503; Gregg, A.J., Fortier, L.A., Mohammed, H.O., Mayr, K.G., Miller, B.J., Haupt, J.L., Assessment of the catabolic effects of interleukin-1beta on proteoglycan metabolism in equine cartilage cocultured with synoviocytes (2006) Am J Vet Res, 67, pp. 957-962; Lin, W.Y., Sadhasivam, S., Lin, F.H., The dose dependent effects of betulin on porcine chondrocytes (2009) Process Biochem, 44, pp. 678-684; Chen, P.Y., Hsu, C.C., Yang, K.C., Wu, C.C., Wang, C.L., The effects of negative pressure treatment on the extracellular matrix gene expression and protein production of fibroblasts (2015) Process Biochem, 50, pp. 1662-1668; Yang, S.H., Lin, C.C., Hu, M.H., Shih, T.T., Sun, Y.H., Lin, F.H., Influence of age-related degeneration on regenerative potential of human nucleus pulposus cells (2010) J Orthop Res, 28, pp. 379-383; Chen, M.P., Yang, S.H., Chou, C.H., Yang, K.C., Wu, C.C., Cheng, Y.H., Lin, F.H., The chondroprotective effects of ferulic acid on hydrogen peroxide-stimulated chondrocytes: Inhibition of hydrogen peroxide-induced pro-inflammatory cytokines and metalloproteinase gene expression at the mRNA level (2010) Inflamm Res, 59, pp. 587-595; Yang, K.C., Chen, H.T., Wu, C.C., Lian, Y.J., Chen, L.L., Sumi, S., Huang, T.L.L., Glutamine regulates the expression of matrix proteins, pro-inflammatory cytokines and catabolic enzymes in IL-1β-stimulated human chondrocytes (2016) Process Biochem, 51, pp. 414-421; Mathy-Hartert, M., Hogge, L., Sanchez, C., Deby-Dupont, G., Crielaard, J.M., Henrotin, Y., Interleukin-1beta and interleukin-6 disturb the antioxidant enzyme system in bovine chondrocytes: A possible explanation for oxidative stress generation (2008) Osteoarthritis Cartilage, 1649, p. 763; Wang, C.T., Lin, Y.T., Chiang, B.L., Lin, Y.H., Hou, S.M., High molecular weight hyaluronic acid down-regulates the gene expression of osteoarthritis-associated cytokines and enzymes in fibroblast-like synoviocytes from patients with early osteoarthritis (2006) Osteoarthritis Cartilage, 50, pp. 1237-1247; Kataoka, Y., Ariyoshi, W., Okinaga, T., Kaneuji, T., Mitsugi, S., Takahashi, T., Nishihara, T., Mechanisms involved in suppression of ADAMTS4 expression in synoviocytes by high molecular weight hyaluronic acid (2013) Biochem Biophys Res Commun, 432, pp. 580-585; Sakkas, L.I., Scanzello, C., Johanson, N., Burkholder, J., Mitra, A., Salgame, P., Katsetos, C.D., Platsoucas, C.D., T cells and T-cell cytokine transcripts in the synovial membrane in patients with osteoarthritis (1998) Clin Diagn Lab Immunol, 5, pp. 430-437; Moos, V., Fickert, S., Muller, B., Weber, U., Sieper, J., Immunohistological analysis of cytokine expression in human osteoarthritic and healthy cartilage (1999) J Rheumatol, 26, pp. 870-879; Martel-Pelletier, J., Pathophysiology of osteoarthritis (2004) Osteoarthritis Cartilage, 12, pp. S31-S33; Chakraborti, S., Mandal, M., Das, S., Mandal, A., Chakraborti, T., Regulation of matrix metalloproteinases: An overview (2003) Mol Cell Biochem, 253, pp. 269-285; Stannus, O., Jones, G., Cicuttini, F., Parameswaran, V., Quinn, S., Burgess, J., Ding, C., Circulating levels of IL-6 and TNF-α are associated with knee radiographic osteoarthritis and knee cartilage loss in older adults (2010) Osteoarthritis Cartilage, 18, pp. 1441-1447; Doss, F., Menard, J., Hauschild, M., Kreutzer, H.J., Mittlmeier, T., Müller-Steinhardt, M., Müller, B., Elevated IL-6 levels in the synovial fluid of osteoarthritis patients stem from plasma cells (2007) Scand J Rheumatol, 36, pp. 136-139; van de Loo, F.A., Kuiper, S., van Enckevort, F.H., Arntz, O.J., van den Berg, W.B., Interleukin-6 reduces cartilage destruction during experimental arthritis. A study in interleukin-6-deficient mice (1997) Am J Pathol, 151, pp. 177-191; de Hooge, A.S., van de Loo, F.A., Bennink, M.B., Arntz, O.J., de Hooge, P., van den Berg, W.B., Male IL-6 gene knock out mice developed more advanced osteoarthritis upon aging (2005) Osteoarthritis Cartilage, 13, pp. 66-73; Silacci, P., Dayer, J.M., Desgeorges, A., Peter, R., Manueddu, C., Guerne, P.A., Interleukin (IL)−6 and its soluble receptor induce TIMP-1 expression in synoviocytes and chondrocytes, and block IL-1-induced collagenolytic activity (1998) J Biol Chem, 273, p. 13625
N2 - Intra-articular injection of hyaluronic acid (HA) has been widely accepted for the treatment of osteoarthritis (OA) in early stage. l-Glutathione (GSH), an antioxidant, has an anti-inflammatory effect on protecting cells from reactive oxygen species and reactive nitrogen species (ROS/RNS). In this study, the therapeutic effects of HA (0.1%) supplemented with GSH (0, 5, 10, and 20% in weight ratios to HA) on human fibroblast-like synoviocytes (FLSs) were evaluated. The results showed that cell morphology and glycosaminoglycan production of FLSs were not changed under treatments. However, the addition of HA + 20% GSH significantly decreased cell survival (p <0.001) relative to other groups. Relative to un-stimulated FLSs, interleukin-1 beta (IL-1β) stimulation significantly decreased the total antioxidant capacity (p <0.001) of cells. The antioxidant capacity was restored and the intracellular ROS/RNS was decreased in HA or HA + GSH-treated FLSs. Real-time PCR analysis revealed the mRNA levels of IL-1β, tumor necrosis factor-alpha, and matrix metalloproteinase-3 were down-regulated significantly (all p <0.05) when FLSs cultured in HA or HA + GSH. IL-6 mRNA expressions were down-regulated significantly in HA and HA + 5% GSH groups (both p <0.05) but up-regulated when HA supplemented with 10% and 20% GSH (both p <0.01). In addition, the protein levels of IL-1β were further decreased with significant differences (both p <0.05) in the HA + 10% GSH and HA + 20% GSH groups when compared to FLSs cultured in normal medium. In conclusion, HA supplemented with GSH improves antioxidant capacity and modulates pro-inflammatory cytokines expressions in FLSs. GSH has the potential to augment the effect of viscosupplementation using HA on OA patients. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2071–2079, 2016. © 2016 Wiley Periodicals, Inc.
AB - Intra-articular injection of hyaluronic acid (HA) has been widely accepted for the treatment of osteoarthritis (OA) in early stage. l-Glutathione (GSH), an antioxidant, has an anti-inflammatory effect on protecting cells from reactive oxygen species and reactive nitrogen species (ROS/RNS). In this study, the therapeutic effects of HA (0.1%) supplemented with GSH (0, 5, 10, and 20% in weight ratios to HA) on human fibroblast-like synoviocytes (FLSs) were evaluated. The results showed that cell morphology and glycosaminoglycan production of FLSs were not changed under treatments. However, the addition of HA + 20% GSH significantly decreased cell survival (p <0.001) relative to other groups. Relative to un-stimulated FLSs, interleukin-1 beta (IL-1β) stimulation significantly decreased the total antioxidant capacity (p <0.001) of cells. The antioxidant capacity was restored and the intracellular ROS/RNS was decreased in HA or HA + GSH-treated FLSs. Real-time PCR analysis revealed the mRNA levels of IL-1β, tumor necrosis factor-alpha, and matrix metalloproteinase-3 were down-regulated significantly (all p <0.05) when FLSs cultured in HA or HA + GSH. IL-6 mRNA expressions were down-regulated significantly in HA and HA + 5% GSH groups (both p <0.05) but up-regulated when HA supplemented with 10% and 20% GSH (both p <0.01). In addition, the protein levels of IL-1β were further decreased with significant differences (both p <0.05) in the HA + 10% GSH and HA + 20% GSH groups when compared to FLSs cultured in normal medium. In conclusion, HA supplemented with GSH improves antioxidant capacity and modulates pro-inflammatory cytokines expressions in FLSs. GSH has the potential to augment the effect of viscosupplementation using HA on OA patients. © 2016 Wiley Periodicals, Inc. J Biomed Mater Res Part A: 104A: 2071–2079, 2016. © 2016 Wiley Periodicals, Inc.
KW - fibroblast-like synoviocyte
KW - glutathione
KW - hyaluronic acid
KW - osteoarthritis
KW - Antioxidants
KW - Cell culture
KW - Cells
KW - Cytology
KW - Enzyme activity
KW - Fibroblasts
KW - Organic acids
KW - Peptides
KW - Polymerase chain reaction
KW - Tissue
KW - Glutathiones
KW - Intra-articular injection
KW - Matrix-metalloproteinase-3
KW - Pro-inflammatory cytokines
KW - Synoviocytes
KW - Total antioxidant capacity
KW - Tumor necrosis factor alpha
U2 - 10.1002/jbm.a.35729
DO - 10.1002/jbm.a.35729
JO - Journal of Biomedical Materials Research - Part B Applied Biomaterials
JF - Journal of Biomedical Materials Research - Part B Applied Biomaterials


Lately, I've been working on improving the things I pay attention to and focus on during the day. Of course, one aspect of this is a to-do list for each day. I spend most of my time in front of a computer, so an online to-do tool makes sense. I've been searching for one that works for me but I'm frustrated with most of the tools I've found — they all seem to manage a wide variety of lists, but don't focus on the symmetry of a day.
There is symmetry in the way we spend our time — the regular rhythm of our lives. Each day follows a similar pattern as the next day. We wake, we eat three meals, we sleep, we do stuff in between. At a broader level, each day of the week resembles the same day in other weeks. Many Mondays are alike. So the two most regularly repeated patterns surround our days and our weeks. There is no smaller pattern of symmetry than a day: one hour is not like the next hour. This makes days the atom of human experience.
In spite of this, I'm surprised that the tools don't structure things around this experience. Sometimes they allow you to assign due dates to items on a list so you can simulate a list for today. The reality is that tasks I want to do today usually aren't "due" today. They may just be what I'm planning. When I'm planning the next day, the things which I didn't get done yesterday are not overdue and I don't want it treating them like they are. At the same time, having just one list doesn't let me plan a week nor does it easily show me what things I got done on various days to reflect on them. The only simple to-do list solution that I have found so far that understands this symmetry is TeuxDeux.
I realize I'm not the first to suggest using days and weeks for planning. I have come to realize how important these symmetries are to managing and reflecting on where we spend our time. On this quest for improving my attention management, I've found a lot of benefit in the Pilot Fire system. It understands the symmetry of planning and is a great system for thinking through the symmetries of life.
I think the link http://www.teuxduex.com/ may be wrong.
Otherwise enjoyed your post, as always.
You're right! Thanks for the pointer Sam! I fixed the post and the link is now correct. Doh!
I'm wondering if the GTD methodology was something you considered and how you thought it would or would not work for you. I've been using it since I read the book about ten years ago. It incorporates concepts like tasks not being "overdue" just because you didn't get to them on a given day; it actually relegates due dates to just the small subset of tasks that truly require one.
"Things" on the iPhone/Mac was great… when I switched to Android, I also switched to Remember the Milk, which is cloud-based.
Thanks for the comment. I've read both GTD and "Making It All Work" and tried using the system as well (though admittedly not as thoroughly as others). I found a lot of the ideas very useful, but find most of his system creates too many lists. I wrote a little on this in a previous post. You're right though that his system doesn't require things be done on a particular day. I really like a lot of the things in his system. Are you able to implement his whole system or do you have certain things that you use most from it?
Thanks for the references and thoughts. I really appreciate it.
Oh, to do! No ton o' dot. Ho!
In my quest for the perfect to do list, I as well stumble upon a few managers, I used things for while, but it killed me the syncing with mobile devices, lately I've been using wunderlist.com it's free, cross-platform, and web based, is still being developed but they have some interesting approach to stuff, so far it has what you expect, due dates starred items, lists, reminders, shared lists, etc. But I guess in the end it wouldn't approach a day with symmetry.
The best tool-technique I've found that is doing wonders for me is the http://www.pomodorotechnique.com/ specially useful for creatives which in my case tend to be hyperactive and ADD and usually procrastinate a lot, it simply focus on getting things done, not the ones you would prefer doing but the ones that need to get done, even if they're not fun or pleasant as Tax work would be probably. This technique has been a life saver to me, I don't use it everyday, but I use it when I seriously need to finish something on a deadline.
Enjoyed the post as always, and I'll take a look of those links. Thanks for sharing.


Are you a techno-optimist, or a techno-pessimist?
People have always been both captivated and challenged by technology. Like many, I grew up watching Star Trek on television, thrilling as Captain Kirk and the crew of the Enterprise explored "strange new worlds." Science fiction allows us to imagine the potential gifts of new knowledge: faster-than-light travel, teleporting, food-synthesis. The possibilities are endless.
But there are always problems. Fire burns. Klingons declare war on humans. There's trouble with tribbles. In the late 19th century, displaced workers threw their wooden shoes, sabots, into machinery to stop it. They were the first "saboteurs." In our day, we give up our privacy to get new smart-phone apps, and self-driving vehicles could put drivers out of work.
An extreme example of these fears is concern over a "singularity," the point where computers may become self-aware and super-intelligent, radically changing civilization. There's even a "Singularity Summit" every year to discuss the implications. Some think a singularity is possible in just a few years.
Technology's problems are everyone's problems. Tools that help us gather food can also be used as weapons. "Man is born to trouble as the sparks fly upwards," the book of Job says. But there's always something new. Our minds are infinite in their capacity to imagine. Our ideas must always be tempered, though, by our core human values: freedom, justice, respect, and love.