I2CNER focuses on science that underline technologies that hold promise for dramatic reductions in carbon emissions in the next 20 to 40 years. Our targets are ambitious, but by leveraging resources and intellectual talent from Japan and the rest of the world, we are optimistic that we can succeed.
A special article featuring Prof. Tsuji's research has been published on Kyushu University's website.
An article of Prof. Tsuji's award has been introduced on "WOWNEWS"
<Award>Asst. Prof. Nguyen Dinh Hoa wins "Best Paper Award"
A news release by Profs. Tsuji, Jia (CO2 Storage Division) and their collaborators published on "EurekAlert!"
150th Institute Interest Seminar Series will be held on April 25th, 2019.
148th Institute Interest Seminar Series took place on Apr. 18th, 2019.
147th Institute Interest Seminar Series took place on Apr. 11th, 2019.
146th Institute Interest Seminar Series took place on Apr. 8th, 2019.
145th Institute Interest Seminar Series took place on Apr. 1st, 2019.


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An inconvenient tea party
By DANIEL LIBIT
10/16/2009 02:57 PM EDT
Irish filmmaker Phelim McAleer couldn't get Hollywood interested in his conservative answer to Al Gore's "Inconvenient Truth," so he's trying to promote it a different way — by getting tea party protesters to turn out for thousands of screenings across the country Sunday night.
McAleer is billing the multicity premiere of "Not Evil Just Wrong" as the world's largest simultaneous film viewing, and he says the "cinematic wing of the tea party movement" is just the ticket for making it work.
"This is tailored-made for the tea party movement," says McAleer. "A small tea party is like a small theater."
To promote the film, McAleer dialed in to Wednesday's weekly conference call for 150 tea party leaders in California. Dawn Wildman, co-coordinator of the California Tea Party Patriots, said the reaction was tremendous.
"I think it is a marvelous idea, in the sense you are actually bringing it to the people," Wildman said.
In San Diego, Wildman is expecting about 150 people to show up at a veterans' museum to watch the film. In Newport Beach, she said, a group of 100 is expected to watch the film at a restaurant. And organizers in Bakersfield are planning on showing the movie three separate times.
While Tea Party protests have so far focused more on government spending than environmental issues like global warming or the cap-and-trade bill working through Congress, tea party leaders says it's time for the movement to branch out.
"It says a lot for the American people and the movement if we can consistently be looking at public policy or fiscal responsibility and evaluate pieces as they come out — whether they be film pieces or books or any kind of intellectual pieces come out," says Everett Wilkinson, a tea party leader in Florida.
And while a few YouTube video clips have helped ignite the conservative base — such as Rick Santelli's on-air diatribe against government bailouts and South Carolina Republican Rep. Joe Wilson's "You lie!" outburst — Wilkinson said it will be a first to see his fellow Tea Party activists moved by film.
McAleer, who will watch the film at a screening in Vancouver on Sunday night, started work on the project in early 2007, about a half-year after the release of "An Inconvenient Truth," Gore's alarm bell on global warming. At first, McAleer's team was small — mostly just him and his wife, Ann McElhinney.
But at the end of 2008, their work got some buzz in the European press and generated interest at the International Documentary Film Festival Amsterdam.
Afterward, McAleer says he flew out Los Angeles, hoping to convince studio executives to give it a feature release. But his efforts came up well short.
He blames it on politics.
"I think if we said the Earth is going to disappear in 30 years and America is responsible, then we would have gotten a release," McAleer said.
So instead, McAleer turned to conservatives for help.
He said he met with Andrew Breitbart, the former Drudge Report editor who now runs a handful of conservative websites, including the one that fanned the flames of the right with videos of ACORN employees encouraging the efforts of actors pretending to seek government funding for brothels. Breitbart's Big Hollywood site will stream the movie Sunday.
In February, McAleer presented his film at the CPAC conference, taking the stage right before Rush Limbaugh. And he's hit every big conservative gathering along the way, including the RightOnLine National Conference in Pittsburgh and the Americans for Prosperity's Defending the American Dream Summit in Washington earlier this month.
McAleer received support from Grover Norquist's Americans for Tax Reform, which e-mailed supporters, and the Heritage Foundation, which will be screening the main premiere on Sunday.
As much as McAleer has sought support from the right, he credits liberal filmmaker Michael Moore with paving the way for his kind of documentary.
"I am the son of Michael Moore," says McAleer, "or at least the illegitimate nephew."
Phil Kerpen, director of policy for Americans for Prosperity, also sees the shoe-on-the-other-foot connection.
"Michael Moore, who was once the guerrilla, down-in-the-weeds documentarian, is releasing big Hollywood pictures, and it is right-wing conservative activists crashing events."
McAleer seemed to rip a page straight out of Moore's publicity playbook when he confronted Gore last week at the Society of Environmental Journalists conference in Madison, Wis. Taking to a microphone in the audience, McAleer pressed Gore about a British High Court judge's findings of inconsistencies in the former vice president's documentary, leading to a confrontation that ultimately ended up with his microphone being cut off.
Though McAleer insisted that there wasn't "any grand plan" behind his exchange with Gore, it provided him precisely the kind of publicity he wanted — presenting him as the intrepid truth-seeker muzzled by the evil liberal media.
But while McAleer is happy to promote his movie through conservative circles, he bristled at being characterized as a conservative activist himself. A former reporter for the Irish News and correspondent for the London Sunday Times, he says he is now just a journalist with a video camera.
A spokeswoman for Gore declined to comment about the film.
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He Was Given 6 Months to Live. Then He Changed D.C.
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Leah Hing (1907–2001) was the first Chinese American woman to earn her pilot's license. Trained by Tex Rankin, an early aviation pioneer at Pearson Field in Vancouver, Washington, she received her pilot's license in 1934. Later she became an instrument mechanic during World War II at a Portland air base.

Childhood
Hing grew up near Salem, Oregon, and spent her school breaks working on her father's hops ranch.  Her mother, Ah Sin Hing, had emigrated from Canton, China: her father, Lee Hing, was born in Oregon.  She had two sisters, Lily and Ruth, and one brother, Peter.  When she was five years old, her father bought a house in the Ladd's Addition neighborhood of Portland.  Hing would live in Ladd's Addition for the rest of her life.  Hing was a member of the Tanda Campfire Girls and president of the Portland Chinese Girls' Club.  Her family were members of the Holt Presbyterian Church.  She attended Atkinson Elementary School, Stephens Middle School, Washington High School, and the Northwestern Business College.  In 1927, she danced in the Portland Rose Festival alongside seventeen other Chinese-American girls, including her lifelong friend Lillian Lang and future pilots Hazel Ying Lee and Virginia Wong.  Hing was one of the first Chinese-American women in Portland hired as an elevator operator.

Vaudeville tour

In 1927, Hing and five other young women founded the Portland Chinese Girls' Orchestra under the umbrella of the Portland Chinese Girls' Club.  Hing played the saxophone, and was accompanied by cymbals, drums, xylophone, trombone, and banjo.  Lillian Lang and Virginia Wong were also members.  After three years of local performances, they joined The Honorable Wu's Vaudeville Troupe and took their show on the road.  The band allowed them to travel America at a time when few jobs were open to Chinese-American women.  At the time they left, they ranged in age from eighteen to twenty-two.   They spent a year touring the U.S. and Canada, but only played one song, "Happy Days Are Here Again."  Family friend Patsy Lee said that they "just lived hand-to-mouth, but they were able to travel."  While they were playing in Chicago, Hing took her first airplane ride at a school for Chinese-American aviators.  She returned to Portland determined to become a pilot.

Aviation career

Rankin Flying School
Hing managed the Chinese Tea Garden restaurant, where her father was a stockholder.  While working there, she met Tex Rankin, who recruited her for his flying school.  Rankin had taught Native American pilot Mary Riddle and was interested in creating "a 'rainbow', all-female stunt team", though the group never materialized.

In March 1932, Hing had her first flying lesson.  According to her teacher, Tex Rankin, she was a remarkably quick learner.  He shared more details in the Oregonian: "The first lesson consists of control exercises; the use of the rudder in the extremes, full rudder to the right and full rudder to the left; the use of the allerons, banking the ship vertically to the left and then to the right, and the use of the elevators, diving and zooming the ship several times.  The trick is to learn to use all three together.  This Miss Hing did after only ten minutes, and at the end of 15 minutes she pulled the throttle back and put the ship into a glide, landing it with little difficulty.  I coached her through the speaking tube, but she did everything right.  That's unusual the first time for anyone."

Chinese-American Flying School
Hing, who had family in China, wanted to become an aviation instructor for Chinese women.  "I believe that women can learn to fly as easily as men," she told reporters, "and that eventually there will be just as many women flying as men."  It was her opinion that "a country sees only through the eyes of its fliers."  After the Japanese invasion of Manchuria in 1931, Portland became the site of a Chinese-American flying school, with the aim of training students to become fighter pilots in the Second Sino-Japanese War.  Hing wanted to attend, but her father forbade it.  However, he did allow her to buy her own aircraft, a 1931 B-5 Kinner Fleet biplane, which she used to perform in airshows up and down the West Coast.  She once made a surprise visit to her brother and sister-in-law's farm in Aurora, Oregon, landing her plane in their wheat field.  By 1942, she had accumulated over 200 hours of flying time.

Plane crashes
Hing once collided with a pothole on the runway, flipping her plane onto its back, and had to have it rebuilt.  In 1936, Lacey Murrow, brother of Edward R. Murrow, crashed his plane into Leah's while trying to land.  Her plane, which was parked and unoccupied, sustained 500 dollars' worth of damage.  The Murrow brothers bought Leah's plane: she spent the money on a Travel Air plane once owned by stunt pilot Dorothy Hester Stenzel. In 1937, she crashed her plane while landing at the Boeing Field airport in Washington.  The plane was severely damaged, and Hing and her passenger received minor injuries.

World War II
During World War II, Hing worked at the Portland Air Base, checking and repairing flight instruments.  She also enlisted in the West Coast Civil Air Patrol to fly reconnaissance missions.  After the internment of Japanese Americans, Hing and many other Chinese-Americans began wearing buttons identifying them as Chinese.  Hing recalled that "we were very proud, and we didn't want to get mixed up with the Japanese."

The Ninety-Nines
Hing joined the Oregon section of The Ninety-Nines when the chapter was revived in 1941. She served as secretary-treasurer and notified members of upcoming meetings.

Aero Club
Hing and Lang found jobs at the Aero Club of Oregon.  Hing worked there as a switchboard operator and hat check girl until she retired in her sixties.  A 1936 Oregonian article said she "knows every hat that was ever bounced upon the counter."

Community involvement
Hing helped immigrants navigate the citizenship process.  Patsy Lee said that "she drilled them for months before they took their tests.  And she gave them other information.  Instead of going to a lawyer, people would go to her."

Hing was general manager of the Chung Wah Hoopers, Portland Chinatown's all-girl basketball team, which played an annual benefit game to raise money for poor and elderly Chinese-Americans to buy food.  In 1932, she and Lang assisted with a reception for a medical missionary traveling to China.

Personal life
Hing's sister, Lily, died on March 10, 1933.   Her father died in 1956, at the age of 85.  Her mother died a year later.

Hing served as a bridesmaid in her brother's 1934 wedding to Gertrude Johnsang.  She herself turned down several marriage proposals, saying she "liked her independence."  In addition to her aviation career, she "sold insurance, had her own watch-repair business and was a professional photographer."  She traveled internationally and across the United States with her parents and Lang.  Hing and Lang were well-known for the parties they threw in Ladd's Addition.

Historian Jackie Peterson described her as having "a remarkable ability to take in life and enjoy it."  According to her sister-in-law, Gertrude Johnsang Hing:"There was just something about her.  She kept everyone laughing.  And she had a lot of gumption.  I don't think her parents were modern, but they couldn't hold her back.  She was going to do what she wanted to do." Hing died of cancer and heart failure in July 2001.

Legacy

Hing is portrayed in a mural of female Oregon aviators at the Portland International Airport.  Her story was featured in the Multnomah County Library's 2012 exhibit "Flying Tigers: Chinese American Aviators in Oregon, 1918-1945" and the Oregon Historical Society's 2016 exhibit, "Beyond the Gate".  Hing's first plane is displayed in the Pearson Air Museum.

See also

 Hazel Ying Lee
 Bessie Coleman
 Mary Riddle
 Dorothy Hester Stenzel
 Arthur Chin
 Henry Hope Wong
 Rose Lok
 Lee Ya-Ching
Tex Rankin

References

1907 births
2001 deaths
American women aviators
American aviators of Chinese descent
Aviators from Portland, Oregon
20th-century American women
20th-century American people

redpajama_set_name: RedPajamaWikipedia


Endocrine abnormalities are common among childhood cancer survivors. Abnormalities of the hypothalamic–pituitary–adrenal axis (HPAA) are relatively less common, but the consequences are severe if missed. Patients with tumours located and/or had surgery performed near the hypothalamic–pituitary region and those treated with an accumulative cranial radiotherapy dose of over 30 Gy are most at risk of adrenocorticotrophic hormone (ACTH) deficiency. Primary adrenal insufficiency may occur in patients with tumours located in or involving one or both adrenals. The effects of adjunct therapies also need to be considered, particularly, new immunotherapies. High-dose and/or prolonged courses of glucocorticoid treatment can result in secondary adrenal insufficiency, which may take months to resolve and hence reassessment is important to ensure patients are not left on long-term replacement steroids inappropriately. The prevalence and cumulative incidences of HPAA dysfunction are difficult to quantify because of its non-specific presentation and lack of consensus regarding its investigations. The insulin tolerance test remains the gold standard for the diagnosis of central cortisol deficiency, but due to its risks, alternative methods with reduced diagnostic sensitivities are often used and must be interpreted with caution. ACTH deficiency may develop many years after the completion of oncological treatment alongside other pituitary hormone deficiencies. It is essential that health professionals involved in the long-term follow-up of childhood cancer survivors are aware of individuals at risk of developing HPAA dysfunction and implement appropriate monitoring and treatment.
Compelling epidemiological evidence shows a strong positive correlation of obesity with thyroid cancer. In vivo studies have provided molecular evidence that high-fat-diet-induced obesity promotes thyroid cancer progression by aberrantly activating leptin-JAK2-STAT3 signaling in a mouse model of thyroid cancer (Thrb PV/PV Pten +/ − mice). The Thrb PV/PV Pten +/ − mouse expresses a dominantly negative thyroid hormone receptor β (denoted as PV) and a deletion of one single allele of the Pten gene. The Thrb PV/PV Pten +/ − mouse spontaneously develops follicular thyroid cancer, which allows its use as a preclinical mouse model to test potential therapeutics. We recently showed that inhibition of STAT3 activity by a specific inhibitor markedly delays thyroid cancer progression in high-fat-diet-induced obese Thrb PV/PV Pten +/ − mice (HFD-Thrb PV/PV Pten +/ − mice). Further, metformin, a widely used antidiabetic drug, blocks invasion and metastasis, but not thyroid tumor growth in HFD-Thrb PV/PV Pten +/ − mice. To improve efficacy in reducing thyroid tumor growth, we treated HFD-Thrb PV/PV Pten +/ − with JQ1, a potent inhibitor of the activity of bromodomain and extraterminal domain (BET) and with metformin. We found that the combined treatment synergistically suppressed thyroid tumor growth by attenuating STAT3 and ERK signaling, resulting in decreased anti-apoptotic key regulators such as Mcl-1, Bcl-2 and survivin and increased pro-apoptotic regulators such as Bim, BAD and cleave caspase 3. Furthermore, combined treatment of JQ1 and metformin reduced cMyc protein levels to suppress vascular invasion, anaplasia and lung metastasis. These findings indicate that combined treatment is more effective than metformin alone and suggest a novel treatment modality for obesity-activated thyroid cancer.
Activation of cyclin-dependent kinase activity is frequently observed in many human cancers; therefore, cyclin-dependent kinases that promote cell cycle transition and cell proliferation may be potential targets in the treatment of malignancy. The therapeutic effects of roniciclib, a cyclin-dependent kinase inhibitor for papillary and follicular thyroid cancer (designated as well-differentiated thyroid cancer), were investigated in this study. Roniciclib inhibited cell proliferation in two papillary and two follicular thyroid cancer cell lines in a dose-dependent manner. Roniciclib activated caspase-3 activity and induced apoptosis. Cell cycle progression was arrested in the G2/M phase. Roniciclib treatment in vivo retarded the growth of two well-differentiated thyroid tumors in xenograft models in a dose-dependent fashion. Furthermore, the combination of roniciclib with sorafenib was more effective than either single treatment in a follicular thyroid cancer xenograft model. Acceptable safety profiles appeared in animals treated with either roniciclib alone or roniciclib and sorafenib combination therapy. These findings support roniciclib as a potential drug for the treatment of patients with well-differentiated thyroid cancer.
Lymph node metastasis (LNM) in papillary thyroid cancer (PTC) is related to increased risk of recurrence and poor prognosis. Tumour exosomes have been shown to be associated with metastasis of cancer cells. Therefore, we aim to identify the characteristics and biological functions of serum exosomes in lymph node metastases of PTC. We compared proteome profiles of serum-purified exosomes (SPEs) from PTC patients with LNM, PTC patients without LNM, and healthy donors, using a combination of liquid chromatography-tandem mass spectroscopy analyses and tandem mass tag label quantitation analysis. We identified 1569 proteins by two or more unique peptides. Compared with the SPEs of PTC patients without LNM, we found 697 differentially expressed proteins in the SPEs of PTC patients with LNM. Our results revealed overexpression of specific proteins with well-established links to cancer cell metastasis, such as SRC, TLN1, ITGB2 and CAPNS1. Consistent with mass spectrum results, we performed Western blot to detect the expression of these proteins in individual sample. Biological pathway analyses showed that integrin signalling was aberrantly activated in the SPEs of PTC patients with LNM compared to those without LNM. Our study reveals that SPEs of PTC patients with lymph node metastases promote BHT101 thyroid cancer cell invasiveness, but have no apparent influence on cell migration. In the serum exosomes of PTC patients with LNM, integrin-associated proteins are obviously upregulated. These proteomic findings will contribute to elucidation of the pathophysiological functions of tumour-derived exosomes.
Mitochondria play important roles in growth, signal transduction, division, tumorigenesis and energy metabolism in epithelial ovarian carcinomas (EOCs) without an effective biomarker. To investigate the proteomic profile of EOC mitochondrial proteins, a 6-plex isobaric tag for relative and absolute quantification (iTRAQ) proteomics was used to identify mitochondrial expressed proteins (mtEPs) in EOCs relative to controls, followed by an integrative analysis of the identified mtEPs and the Cancer Genome Atlas (TCGA) data from 419 patients. A total of 5115 quantified proteins were identified from purified mitochondrial samples, and 262 proteins were significantly related to overall survival in EOC patients. Furthermore, 63 proteins were identified as potential biomarkers for the development of an EOC, and our findings were consistent with previous reports on a certain extent. Pathway network analysis identified 70 signaling pathways. Interestingly, the results demonstrated that cancer cells exhibited an increased dependence on mitophagy, such as peroxisome, phagosome, lysosome, valine, leucine and isoleucine degradation and fatty acid degradation pathways, which might play an important role in EOC invasion and metastasis. Five proteins (GLDC, PCK2, IDH2, CPT2 and HMGCS2) located in the mitochondrion and enriched pathways were selected for further analysis in an EOC cell line and tissues, and the results confirmed reliability of iTRAQ proteomics. These findings provide a large-scale mitochondrial proteomic profiling with quantitative information, a certain number of potential protein biomarkers and a novel vision in the mitophagy bio-mechanism of a human ovarian carcinoma.
Pancreatic neuroendocrine tumors (panNETs) are often inoperable at diagnosis. The mTORC1 inhibitor everolimus has been approved for the treatment of advanced NETs. However, the regular development of resistance to everolimus limits its clinical efficacy. We established two independent everolimus-resistant panNET (BON1) cell lines (BON1 RR1, BON1 RR2) to find potential mechanisms of resistance. After 24 weeks of permanent exposure to 10 nM everolimus, BON1 RR1 and BON1 RR2 showed stable resistance with cellular survival rates of 96.70% (IC50 = 5200 nM) and 92.30% (IC50 = 2500 nM), respectively. The control cell line showed sensitivity to 10 nM everolimus with cellular survival declining to 54.70% (IC50 = 34 nM). Both resistant cell lines did not regain sensitivity over time and showed persistent stable resistance after a drug holiday of 13 weeks. The mechanisms of resistance in our cell line model included morphological adaptations, G1 cell cycle arrest associated with reduced CDK1(cdc2) expression and decreased autophagy. Cellular migration potential was increased and indirectly linked to c-Met activation. GSK3 was over-activated in association with reduced baseline IRS-1 protein levels. Specific GSK3 inhibition strongly decreased BON1 RR1/RR2 cell survival. The combination of everolimus with the PI3Kα inhibitor BYL719 re-established everolimus sensitivity through GSK3 inhibition and restoration of autophagy. We suggest that GSK3 over-activation combined with decreased baseline IRS-1 protein levels and decreased autophagy may be a crucial feature of everolimus resistance, and hence, a possible therapeutic target.
Cell plasticity of 'stem-like' cancer-initiating cells (CICs) is a hallmark of cancer, allowing metastasis and cancer progression. Here, we studied whether simvastatin, a lipophilic statin, could impair the metastatic potential of CICs in high-grade serous ovarian cancer (HGS-ovC), the most lethal among the gynecologic malignancies. qPCR, immunoblotting and immunohistochemistry were used to assess simvastatin effects on proteins involved in stemness and epithelial-mesenchymal cell plasticity (EMT). Its effects on tumor growth and metastasis were evaluated using different models (e.g., spheroid formation and migration assays, matrigel invasion assays, 3D-mesomimetic models and cancer xenografts). We explored also the clinical benefit of statins by comparing survival outcomes among statin users vs non-users. Herein, we demonstrated that simvastatin modifies the stemness and EMT marker expression patterns (both in mRNA and protein levels) and severely impairs the spheroid assembly of CICs. Consequently, CICs become less metastatic in 3D-mesomimetic models and show fewer ascites/tumor burden in HGS-ovC xenografts. The principal mechanism behind statin-mediated effects involves the inactivation of the Hippo/YAP/RhoA pathway in a mevalonate synthesis-dependent manner. From a clinical perspective, statin users seem to experience better survival and quality of life when compared with non-users. Considering the high cost and the low response rates obtained with many of the current therapies, the use of orally or intraperitoneally administered simvastatin offers a cost/effective and safe alternative to treat and potentially prevent recurrent HGS-ovCs.
In pituitary adenomas, early recurrences and resistance to conventional pharmacotherapies are common, but the mechanisms involved are still not understood. The high expression of epidermal growth factor receptor 2 (HER2)/extracellular signal-regulated kinase (ERK1/2) signal observed in human pituitary adenomas, together with the low levels of the antimitogenic transforming growth factor beta receptor 2 (TBR2), encouraged us to evaluate the effect of the specific HER2 inhibition with trastuzumab on experimental pituitary tumor cell growth and its effect on the antiproliferative response to TGFB1. Trastuzumab decreased the pituitary tumor growth as well as the expression of ERK1/2 and the cell cycle regulators CCND1 and CDK4. The HER2/ERK1/2 pathway is an attractive therapeutic target, but its intricate relations with other signaling modulators still need to be unraveled. Thus, we investigated possible cross-talk with TGFB signaling, which has not yet been studied in pituitary tumors. In tumoral GH3 cells, co-incubation with trastuzumab and TGFB1 significantly decreased cell proliferation, an effect accompanied by a reduction in ERK1/2 phosphorylation, an increase of SMAD2/3 activation. In addition, through immunoprecipitation assays, a diminution of SMAD2/3-ERK1/2 and an increase SMAD2/3–TGFBR1 interactions were observed when cells were co-incubated with trastuzumab and TGFB1. These findings indicate that blocking HER2 by trastuzumab inhibited pituitary tumor growth and modulated HER2/ERK1/2 signaling and consequently the anti-mitogenic TGFB1/TBRs/SMADs cascade. The imbalance between HER2 and TGFBRs expression observed in human adenomas and the response to trastuzumab on experimental tumor growth may make the HER2/ERK1/2 pathway an attractive target for future pituitary adenoma therapy.
Prolactinoma represents the most frequent hormone-secreting pituitary tumours. These tumours appear in a benign form, but some of them can reach an invasive and aggressive stage through an unknown mechanism. Discovering markers to identify prolactinoma proliferative and invading character is therefore crucial to develop new diagnostic/prognostic strategies. Interestingly, members of the TGFβ-Activin/BMP signalling pathways have emerged as important actors of pituitary development and adult function, but their role in prolactinomas remains to be precisely determined. Here, using a heterotopic allograft model derived from a rat prolactinoma, we report that the Activins orphan type I receptor ALK7 is ectopically expressed in prolactinomas-cells. Through immunohistological approaches, we further confirm that normal prolactin-producing cells lack ALK7-expression. Using a series of human tumour samples, we show that ALK7 expression in prolactinomas cells is evolutionary conserved between rat and human. More interestingly, our results highlight that tumours showing a robust expression of ALK7 present an increased proliferation as address by Ki67 expression and retrospective analysis of clinical data from 38 patients, presenting ALK7 as an appealing marker of prolactinoma aggressiveness. Beside this observation, our work pinpoints that the expression of prolactin is highly heterogeneous in prolactinoma cells. We further confirm the contribution of ALK7 in these observations and the existence of highly immunoreactive prolactin cells lacking ALK7 expression. Taken together, our observations suggest that Activin signalling mediated through ALK7 could therefore contribute to the hormonal heterogeneity and increased proliferation of prolactinomas.
In the last few years, the therapeutic approach for neuroendocrine neoplasms (NENs) has changed dramatically following the approval of several novel targeted treatments. The multitarget tyrosine kinase inhibitor (MTKI), sunitinib malate, has been approved by Regulatory Agencies in pancreatic NENs. The MTKI class, however, includes several other molecules (approved for other conditions), which are currently being studied in NENs. An in-depth review on the studies published on the MTKIs in neuroendocrine tumors such as axitinib, cabozantinib, famitinib, lenvatinib, nintedanib, pazopanib, sorafenib and sulfatinib was performed. Furthermore, we extensively searched on the Clinical Trial Registries databases worldwide, in order to collect information on the ongoing clinical trials related to this topic. Our systematic analysis on emerging MTKIs in the treatment of gastroenteropancreatic and lung NENs identifies in vitro and in vivo studies, which demonstrate anti-tumor activity of diverse MTKIs on neuroendocrine cells and tumors. Moreover, for the first time in the literature, we report an updated view concerning the upcoming clinical trials in this field: presently, phase I, II and III clinical trials are ongoing and will include, overall, a staggering 1667 patients. This fervid activity underlines the increasing interest of the scientific community in the use of emerging MTKIs in NEN treatment.


Playing chess with a pigeon is the analogy I think about . No matter how good you are all it will do is flap its wings , knock things over, poop on the board then fly off thinking it's won.
cosmicbike, JhnBssll, FishFright and 2 others like this.
It was once again repeated in the Guardian just a few weeks ago that Audi drivers are more likely to have a motoring conviction than any other, BMW drivers a close second, and Mercedes drivers a distant third.
Had this last night as I was turning into my road. A quite new, very noisy, very fast Merc came blasting past me from behind doing 70-80mph in a 30 zone!!!!!! FFS, instant death to anyone that inadvertently got in their way, what are these people thinking? I know I am not wrong about the speed as I spend a lot of time around cars and have been known to drive enthusiastically myself. Another thing I don't understand is, if you are going to drive like a nob and break the law why all the noise and show? You would at least try to be discreet about it and not attract attention to yourself.
fossyant and C R like this.
Another thing I don't understand is, if you are going to drive like a nob and break the law why all the noise and show? You would at least try to be discreet about it and not attract attention to yourself.
Edit: and it's always on 'full nobber' when you start it up, specifically to impress the neighbours.
I like Skol and Andy in Germany like this.
Threevok, DCBassman and I like Skol like this.
Jenkins, Drago, Alan O and 4 others like this.
I'd be willing to bet that those German saloons are disproportionately represented amongst the 10% of cars that are uninsured.
This thread isn't making sense. OP, can you be explicit? Did the police witness it and that's why they're speaking with him. If not, what is going on?
glasgowcyclist, C R and I like Skol like this.
Good luck with getting an answer to that, I suspect this is another of RR's flights of fancy.
Aye, you've got to ride down stair cases to make it exciting (on a hybrid).
Andy in Germany, Pat "5mph", I like Skol and 1 other person like this.
That's an old E Class with the 'goggle eyes' - I'm surprised it's still on the road with the rust problems they had.
Edit: otherwise going well at 265000 miles.
Edit2: Which means the pump is worth more than the car.
I suspect this is another of RR's flights of fancy.
Who would suggest such a thing?
I only experience a fraction of the experiences that you do, honestly my life is so dull you couldn't make it up.


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Datacenter RPCs Can Be General and Fast
;login: Enters a New Phase of Its Evolution
For over 20 years, ;login: has been a print magazine with a digital version; in the two decades previous, it was USENIX's newsletter, UNIX News. Since its inception 45 years ago, it has served as a medium through which the USENIX community learns about useful tools, research, and events from one another. Beginning in 2021, ;login: will no longer be the formally published print magazine as we've known it most recently, but rather reimagined as a digital publication with increased opportunities for interactivity among authors and readers.
Since USENIX became an open access publisher of papers in 2008, ;login: has remained our only content behind a membership paywall. In keeping with our commitment to open access, all ;login: content will be open to everyone when we make this change. However, only USENIX members at the sustainer level or higher, as well as student members, will have exclusive access to the interactivity options. Rik Farrow, the current editor of the magazine, will continue to provide leadership for the overall content offered in ;login:, which will be released via our website on a regular basis throughout the year.
As we plan to launch this new format, we are forming an editorial committee of volunteers from throughout the USENIX community to curate content, meaning that this will be a formally peer-reviewed publication. This new model will increase opportunities for the community to contribute to ;login: and engage with its content. In addition to written articles, we are open to other ideas of what you might want to experience.
Anuj Kalia, Michael Kaminsky, and David G. Andersen
It is commonly believed that datacenter networking software must sacrifice generality to attain high performance. The popularity of specialized distributed systems designed specifically for niche technologies such as RDMA, lossless networks, FPGAs, and programmable switches testifies to this belief. In this article, we show that such specialization is not necessary. eRPC is a new general-purpose remote procedure call (RPC) library that offers performance comparable to specialized systems while running on commodity CPUs in traditional datacenter networks based on either lossy Ethernet or lossless fabrics.
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Datacenter RPCs Can Be General and Fast (PDF)
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;login: issue:
Summer 2019, Vol. 44, No. 2


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Helps Every Puppy Be ... "Pick of the Litter"
Readily available fuels help combat fatigue.
Features nutrients that support many body systems.
Longevity & Anti-Aging Supplement Friends for life deserve longer lives!


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Agilent Technologies Announces Industry's Most Cost-Effective PCI Express(r) 3.0 Flying Lead Probe
Agilent Technologies Inc. (NYSE: A) recently announced a new flying lead solder-down probe for PCI Express 3.0 protocol analysis. The new U4324A probe, for use with Agilent's U4301A protocol analyzer module, is the industry's most cost-effective solder-down probing solution.
"The PCI Express flying lead probe is designed for simplicity, flexibility and low cost," said Rob Vezina, a PCI Express product marketing engineer at Agilent. "It cleanly captures 8.0 GT/s traces from the device under test while it eliminates the need to buy more expensive solder-down probes that contain wires that are unused for the testing application."
Other probes on the market come equipped with 16, unmappable leads, resulting in unused leads that increase the price of the probe, even though they are not useful for today's most common channel tests. Agilent's U4324A flying lead probe can be used for bidirectional lane widths as narrow as x2, making it the most cost-effective solution for capturing 8 GT/s traces in the industry. It was designed with the needs of silicon, system and embedded PC connector testing in mind.
Agilent's U4301A PCI Express 3.0 protocol analyzer can accept up to four flying lead probes, offering support for up to 16 channels. The module's software enables users to remap any available wire on the probe. It also supports bidirectional capability, upstream or downstream, for every channel. What's more, it can map any unused cable to replace a lead that is damaged or broken. Finally, the probe provides an additional line for connection to an external reference clock, and it supports 2.5-GT/s, 5-GT/s and 8-GT/s PCI Express IO speeds.
The most delicate part of any solder-down probe is the tip. To further reduce the cost of testing, Agilent's U4324A PCI Express 3.0 flying lead probe works with Agilent's low-cost, replaceable N5426A ZIF (zero insertion force) tip kit. Each of the four probe leads can then plug into the expendable ZIF tip, which is then soldered to the channel on the device under test. The kit allows users to easily replace tips as necessary, ensuring the long life of the Agilent U4324 flying lead solder-down probe.
Additional information is available at www.agilent.com/find/U4324A. A high-resolution screen image of Agilent's U4324A flying lead probe is available at www.agilent.com/find/U4324A_images.
U.S. Pricing and Availability
The U4324A PCI Express 3.0 flying lead solder-down probe and ZIF tip kit are available now. The U4324A starts at approximately $7,000.
PCI Express is a U.S. registered trademark of PCI-SIG.
Labels: Agilent, Digital, News, PCIe, Probes, product introduction, Protocol Analyzer


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Nature Reserve of Saint Barthélemy (Réserve Naturelle de Saint-Barthélemy) is a nature reserve of Saint Barthélemy (RNN 132), French West Indies, an overseas collectivity of France.

Background
Founded in 1996, it covers 1,200 hectares in five sectors: Gros Îlets and Pain de Sucre off Gustavia harbour; the waters surrounding the islets Fourchue, Frégate and Île Toc Vers; and part of Colombier bay. Protected marine areas of the reserve are demarcated on nautical charts of the region. The management of the reserve rests with the Grenat Association. It was established in 1996 with the objective of conserving coral reefs, sea grass beds and the marine life. The reserve has coral formations in an area of .

Fauna
45 coral species are recorded, apart from Ascidiacea, sea sponges and anemones. Sea urchins, starfish, shellfish, crustaceans, a few sea turtles and 165 species of fish are also reported. An invasive species of fish found in this reserve is the lion fish, which is poisonous and has a dangerous bite. The reserve is the habitat of 80 species of birds. The land area is small and its xerophytic vegetation is grazed by goats, causing loss of nestling ground for 15 terrestrial birds. Six species of water birds have also been recorded in the ponds of the island. The bird population witnesses a boost during the winter when a large number of Neotropical migrant birds flock the area. Within the reserve three bird areas have been identified by BirdLife International, which cover an area of , apart from 0.4% of the land area of Saint Barthélemy. The key bird species recorded here are: brown booby (Sula leucogaster); laughing gull (Leucophaeus atricilla); royal tern (Thalasseus maximus); and common tern (Sterna hirundo).

References

Bibliography

External links

IUCN Category IV
Nature reserves in France
Protected areas established in 1996
Landforms of Saint Barthélemy
1996 establishments in Saint Barthélemy


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Places to visit: Lorca
Created on Monday, 17 April 2006 18:15 | Hits: 6086
The ancient town of Lorca, whose urban centre was declared ´a Town of Historical and Artistic Interest´ in 1964, is described as ´the baroque city´, due to the important baroque heritage of its historical centre, one of the most important in the Region, and the historical events that have shaped modern Lorca from the Iron Age to our time.
Its location has been a strategic enclave throughout history. From the Paleolithic period until Roman times, a wide variety of cultures and settlers converged in the town of Lorca. The castle of Lorca, "The Fortress of the Sun", built by the Moors in the 6th century, marked the frontier between the Christian and Muslim kingdoms.
There are a great number of archaeological sites such as the Columna Miliaria (Milestone) from the Roman age, the Tower of Espolón or the Alfonsina Tower, a Christian construction dating from after the Reconquest. There is also the ´Porche de San Antonio´, the gate through the old wall that surrounded the city (in the 10th century), the numerous churches and convents dating from different periods and built in different styles (15th century to the 18th century), the baroque palaces and stately homes, such as the Guevara Palace, the Palace of the Counts of San Julián or Casa de la Mula, the military fortress that restructures the medieval castle, or the paved streets around Plaza de España, with popular architectural buildings imbued with strong traditional character, such as La Zapatería y La Cava.
Lorca is home to some of the most important examples of Spanish baroque, when monastic orders and noble families filled the city with coats of arms, sumptuous mansions and Renaissance buildings, which even today are still a poignant reminder of the city's illustrious past.
Lorca has a population of approximately 100,000. The town blends its historical heritage with modern life. Lorca is one of the most important commercial and cultural centres in the region. It has mountains to a height of 1.500m in the north-west and unspoiled coastal areas. The surrounding areas are covered with vineyards and agriculture.
Visitors are always made more than welcome in Lorca, and its year-round good weather, restaurants, hotels and first-class tourist infrastructures, all combine to add to the rural tourism on offer in the largest district in the Region of Murcia. The city and its nearness to its many mountain chains and areas of great natural beauty make Lorca a place to have a really good time.


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text:
Хефест (; ) в древногръцката митология е бог, покровител на огъня и обработката на метала като ковач. Син на Хера, роден на Олимп. Символът му е наковалня. Докато другите богове съдят хората, водят войни, ходят на лов, Хефест в най-голяма степен може да се нарече занаятчия – трудещият се най-много бог. Аналог на Хефест в римската митология е Вулкан.

Съгласно мита, Хера родила Хефест от себе си, след като се скарала със Зевс.

След като ѝ показали детето, тя се ужасила от хилавото му телце, хванала го за крачето и го хвърлила към земята. Той паднал в океана. Провървяло му, тъй като наблизо била Тетида, дъщерята на морския старец Нерей и нейната приятелка Евринома, дъщеря на Океан. Те го намерили и се грижили за него 9 години. Малкият Хефест не обичал нито музиката, нито танците, които всички други богове знаели до съвършенство. Не го теглело и към войната, тъй като бил куц от падането си. Харесвало му да майстори разни неща. Бързо се научил от къс безформено злато или сребро да изработва прекрасни бижута и неговите възпитателки скоро били изумени от изяществото на това, което излиза изпод ръцете му. Такава красота те не били виждали нито на небето, нито на земята. Изковал щита на Атина, колесницата на Хелиос, доспехите на Ахил, изваял Пандора и др. Зевс разбрал за неговата дарба и наредил на Хефест да построи Тартар с помощта на Хадес.

Съответства на римския бог Вулкан. Установен период на поколение: от около 1499 г. пр. Хр. до християнизацията (около 400 г. сл. Хр.); Синоними: Хефестус (римски); Култови средища: Светилища на остров Лемнос.

Той е имал деца от Аглаеа, Аетна, Кабейро, Гая, Антиклея и още неясни майки. Негови наследници са Юклиа, Ютения, Юфем, Филофросин, Ардалус и други.

Литература
 Marie Delcourt: Héphaistos ou la légende du magicien. Belles Lettres, Paris 1957, ISBN 2-251-33414-9
 Frank Brommer: Die kleinasiatischen Münzen mit Hephaistos. In: Chiron. 2, 1972, S. 531 – 544* Frank Brommer: Hephaistos. Der Schmiedegott in der antiken Kunst. von Zabern, Mainz 1978, ISBN 3-8053-0334-3
 Antoine Hermary, Anne Jaquemin: Hephaistos. In: Lexicon Iconographicum Mythologiae Classicae (LIMC). Band 0004IV, Zürich/München 1988, с. 627 – 654
 Marie Luise Kaschnitz: Hephaistos. In: Marie Luise Kaschnitz: Griechische Mythen. Insel, Frankfurt am Main, Leipzig 2001, ISBN 3-458-17071-5, с. 51 – 62
 Омир, Илиада 1, 571ff., 18, 395ff.
 Хезиод, Werke und Tage 47 – 105, Prometheus und Pandora

Източници

Външни препратки

 Theoi Project, Hephaestus, Theoi Project
 Greek Mythology Link, Hephaestus, maicar.com

Древногръцки богове
Потомство на Хера


Long-Time Hanksville Resident Dies in Moab Mrs. Edna Gibbons Ekker Robison, passed away at 9 a.m. Tuesday August 11, at the Allen Memorial Hospital. Mrs. Robison has been a life long resident to Hanksville. She recently celebrated her 85th birthday on June 1st with her daughter and family, Julia and Larry Cheskaty, in La Mesa. California.


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The abandoned diamond mining town of Kolmanskop is near the western coast and within the 'Sperrgebiet' or forbidden zone proclaimed in 1908 to prevent unauthorised trespass on these rich gem fields. Kolmanskop was abandoned in 1954 and is being taken over by the ever blowing sand.
Kolmanskop's abandoned buildings are a magnet for landscape photographers who work the early and late light. A permit is required to enter the township during these hours.
The historic Atlantic port of Lüderitz is 12 km from Kolmanskop. Dredges still work for alluvial diamonds in the seabed gravel.


text:
Missed Persons
The discovery of human bones near Trier on the Moselle raises many questions
The discovery of human bones near Trier on the Moselle raises many questions	Featured
Palzem, kasaan media, 2020
Published in Missed Persons
Bones, Trier, Germany, Forest,
Uncanny find
At the beginning of December 2019, a hunting party found bones near Trier, in a wooded area near Palzem, which had been lying there in impassable terrain for several years. A hunter had found the bones, which could be attributed to a skeletonized human corpse and informed the police. Because of the terrain, the police appeared at the same time as the fire brigade, which helped to recover the remains.
Who the dead man or woman is, cannot be said at this stage of the investigation. However, no person matching the forensic scientist's description has been reported missing.
A police spokesman, however, explained that a Finnish identity card of a woman was found next to the place where the body was disposed of. Also, the remains of clothing were found that were associated with the body.
The police were also unable to provide any information about the circumstances of death or how the bones got into the forest, or the body. Palzem is located between Trier and the Luxembourg border on the Moselle, just north of the French border in the border triangle.
The remains of the body were taken to the forensic department.
Anyone who can provide information about the unknown deceased or knows anything about the circumstances has made observations, should contact their local police station.
Last modified onSaturday, 14 March 2020 14:17
A very miserable character - Donald John Trump
Who murdered Detlev Karsten Rohwedder?
Missing: Vanished without trace in the empire of King Ludwig II.


text:
Star Studio producer shares her one-year career experience at Children's Minnesota
At Children's Minnesota, we believe children always come first. They are awesomely resilient. Eternally optimistic. Totally fearless. They are what we want to be when we grow up.
Celebrating an incredible 15 years with Star Studio!
To help kids getting care at Children's Minnesota, we launched Star Studio, our in-house TV station, 15 years ago on Jan. 3, 2008. Star Studio is meant to be an oasis for our patients because we believe that kids should get to be kids, no matter what they are going through.
Through the last 15 years, Star Studio has gone through many changes, but something that will never change is the ability of the Star Studio team to put smiles on patients' faces the minute they turn on Channel 13.
We are excited to announce that our employee spotlight this week is Sarah Agnew, a producer from Star Studio! Sarah has been working at Star Studio for a year and she will be sharing all of her favorite thing about her career below.
What's your position and how long have you been at Children's Minnesota?
"I'm a producer at Star Studio, primarily focused on creating new pre-recorded content for the channel. I started Jan. 10, 2022."
What do you like about working at Star Studio?
"I love conceiving and writing content for kids, and then collaborating with others to film and edit. The possibilities for growth on the channel are huge, so I really like the pursuit of providing more BIPOC and LGBTQ+ representation in all of our material so that patients and their families see themselves represented when they tune in to Channel 13. Eating lunch with The Dude is a highlight as well."
How do you feel Star Studio impacts our patients and families?
"It seems to me that it really succeeds in being an oasis for kids and their families while they have to be at the hospital. A place where they can be silly whether they are in-person or watching from their rooms. They can participate in fun with a good dose of playful irreverence."
What has been your favorite moment so far while working at Star Studio?
"This summer we had two kids in hospital waiting for hearts. Getting to know them and their families over an extended amount of time was really impactful to me."
If you could describe Star Studio in one word, what would it be?
Tell us about the significance of Star Studio's 15th anniversary. How does Star Studio plan to celebrate?
"We'll be having two celebrations, one at our Minneapolis hospital and the other at our St. Paul hospital. We'll gather after Bingo and have food, photo booths, Bryce from Drawsome will be there making art and Suzie Juul will be leading karaoke in the studio. We'll have snacks galore. There is a lot to celebrate to see this program begin with a sock puppet and evolve into what it is today!"
Do you love having fun and making an impact at the same time? Star Studio is seeking qualified candidates to join the team!
Star Studio Broadcast Engineer
Mai Songsawatwong January 13, 2023


text:
Q: first of type with global class is not the same as if it is the local class When we have this part of code:

And class Element:
.element {
color:red;
}
.element:first-of-type {
color:blue;
}

And we have two cases:

*

*The first one is when the class element is global.
In this case just the first element of elements1 will be blue

*The second one is when the class "element" is local.
In this case fist elements of both of the arrays will be blue
Why behavior in both cases isn't the same?

A: first-of-type will get the element type using the class, so for example if the class is assigned on a p then the p should be the first of it's type to work so if there is any other p even from another class it will not detect it.

p:first-of-type {color:blue}
.myclass1:first-of-type {color:red}
.myclass2:first-of-type {color:green}

This text should appear as normal

This text should be blue.

This text should appear red.

This text should appear green.

check this also:
CSS3 selector :first-of-type with class name?

A: Try this:

This will set the color only for the first div.

A: :first-of-type means "first of type" and not "first that matches the previous bit of the selector".
The class is irrelevent. The element type is div.

.element {
  color: red;
}

.element:first-of-type {
  color: blue;
}

This is the first div in the section

      This is the second div in the section

This is the first div in the div

This is the second div in the div

This is the first p in the section

This is the second p in the section

redpajama_set_name: RedPajamaStackExchange


Update: The UN and WHO say it's 'highly unlikely' that the refugee had Ebola.
"It does not meet the standard case definition for the disease … however precautions have been taken and continue," says a statement issued by the UN and WHO.
A refugee from overcrowded Nyarugusu refugee camp in western Tanzania has died of a mysterious illness.
The Burundian man is reported to have died in Kigoma's Maweni hospital earlier this week.
According to JamiiForum's editorial website FirkaPevu, the man's symptoms included external bleeding, which is a symptom of Ebola.
Yellow fever, Dengue fever, Lassa virus and Marburg virus — among others — can all cause hemorrhaging.
Speaking to FikraPevu, Maweni Hospital's Acting chief medical officer Shija Ganai says that as a precaution, medical staff have followed strict Ebola quarantine procedures.
Samples have been collected and are being tested to determine the nature of the man's illness.
Nyarugusu refugee camp, near Kigoma, is currently home to over 140,000 refugees.
The camp was designed to hold 50,000.


text:
Professor Koen Steemers BSc BArch MPhil PhD LLD ARB
Koen's current research addresses the architectural and urban implications of environmental issues ranging from energy use to human well-being. He has been Head of Department (2009-14) and Head of Research as Director of the Martin Centre (2003-08). He is an architect and environmental design specialist and was listed as one of the "top 50 most influential people in UK sustainability" by Building Design.
Koen was awarded an honorary Doctor of Laws in 2017 "in recognition of his distinguished career and his international standing as one of the world's experts on sustainable building design" from the University of Bath, regularly UK's top ranking building research institution.
Koen's academic activities are focused on the environmental performance of buildings and cities - with a particular interest in human health, perception and behaviour - which are the topics of funded research projects and his PhD students. Recent major research projects include:
"Behaviour and Building Performance" - Research Centre.
"Pop-Machina" - Maker spaces and the circular economy (July 2019-2023) - EC, 10m Euros.
"MAGIC" - Managing Air for Green Inner Cities (Dec 2015-2020) - EPSRC, £4m.
"Bayesian building energy model" (Sep 2014 - 2017) - EPSRC, £450k.
"Energy Efficient Cities" (Sep 08 – Aug 13) - EPSRC, £2.9m.
"ReVISIONS: Regional visions of integrated sustainable infrastructure optimized for neighbourhoods" (Apr 08 – Sept 12) - EPSRC, £3.3m.
"Low Carbon Urban Design" (July 12 – June 14) - Tsinghua, $600k.
Koen has 200+ outputs (ca. 10,000 citations) and 10 books including "Healthy Homes" (2019), "Energy and Environment in Architecture" (2000), "Daylight Design of Buildings" (2002), "Environmental Diversity in Architecture" (2004) and "Sustainable Urban and Architectural Design" (2006). Click on the titles for further information or access to the publications.
Sample journal articles include (to be updated since 2016):
Anderson, J., Ruggeri, K., Steemers, K., & Huppert, F. (2016). 'Lively Social Space, Well-Being Activity, and Urban Design', Environment and Behaviour, 1-32 (Open Access link).
Yun, G. Y., Lee, J. H., & Steemers, K. (2016). 'Extending the applicability of the adaptive comfort model to the control of air-conditioning systems'. Building and Environment, 105, 13-23. (Open Access link)
Hargreaves, A., Cheng, V., Deshmukh, S., Leach, M., Steemers, K. (2016). 'Forecasting how residential urban form affects the regional carbon savings and costs of retrofitting and decentralized energy supply', Applied Energy, available open access online 28 March 2016 (Open Access link). See also this link for highlights.
Steemers, K. (2015). 'Architecture for Well-being and Health', Daylight & Architecture, 23 (July), 1-22 (available online).
Sharmin, T., Steemers, K., & Matzarakis, A. (2015). 'Analysis of microclimatic diversity and outdoor thermal comfort perceptions in the tropical megacity Dhaka', Bangladesh. Building and Environment, 94 (2), 734-750. (Open Access link)
Godoy-Shimizu, D., Armitage, P., Steemers, K., & Chenvidyakarn, T. (2014). 'Using display energy certificates to quantify pulic sector office energy consumption'. Building Research and Information, Published online 5 Nov 2014.
Hui, B., & Steemers, K. (2014). 'Energy retrofit and occupant behaviour in protected housing: A case study of the Brunswick Centre in London'. Energy and Buildings, 80 120-130. (Open Access link)
Sarralde, J. J., Quinn, D. J., Wiesmann, D., & Steemers, K. (2015). 'Solar energy and urban morphology: Scenarios for increasing the renewable energy potential of neighbourhoods in London'. Renewable Energy, 73, 10-17 (Open Access link)
Armitage, P., Godoy-Shimizu, D., Steemers, K., & Chenvidyakarn, T. (2014). 'Using Display Energy Certificates to quantify public sector office energy consumption'. Building Research and Information, 43 (6), 691-709. (Open Access link)
Chen, J., Wang, X. & Steemers, K. (2013). 'A statistical analysis of a residential energy consumption survey study in Hangzhou, China', Energy and Buildings, 66, Nov., 193-202.
Godoy-Shimizu, D., Armitage, P., Steemers, K., & Chenvidyakarn, T. (2011). 'Using display energy certificates to quantify schools' energy consumption'. Building Research and Information, 39(6), 535-552.
Cheng, V. & Steemers, K. (2011). 'Modelling domestic energy consumption at district scale: A tool to support national and local energy policies', Environmental Modelling and Software, 26(10), 1186-1198.
Steemers, K. & Manchanda, S. (2010). 'Energy efficient design and occupant well-being: Case studies in the UK and India', Building and Environment, 45(2), 270-278.
Steemers, K. & Yun, G.Y. (2009). 'Household energy consumption: a study of the role of occupants', Building Research and Information, 38(1), 625 – 637.
Ratti, C., Baker, N. & Steemers, K. (2005). 'Energy consumption and urban texture', Energy and Buildings, 37(7), 762-776.
Nikolopoulou, M. & Steemers, K. (2003). 'Thermal comfort and psychological adaptation as a guide for designing urban spaces', Energy and Buildings, 35(1), 95–101.
Steemers, K. (2003), 'Energy and the City: Density, buildings and transport', Energy and Buildings, 35(1), 3-14.
Nikolopoulou, M., Baker, N. & Steemers, K. (2001). 'Thermal Comfort in Outdoor Urban Spaces: Understanding the human parameter', Solar Energy, 70(3), 227-235 (winner of the ISB (International Society of Biometeorology) Scientific Award in Human Biometeorology).
Professor of Sustainable Design
Jesus College (Professorial Fellow)
Director of Studies (Jesus College)
Former Head of Department (2009-14)
kas11@cam.ac.uk
http://www.martincentre.arct.cam.ac.uk/research/behaviour-and-building
https://www.arct.cam.ac.uk/research/the-martin-centre/circular-maker-cities-the-…


enable resum for support site as i spend my day to get the flashes with no luck ( slow internet connection ).
put the flashes for MT6226 and others in some folders like other models so we can search easier for the flash we need.
if you have slow Internet connection I suggest you to contact to your reseller and buy from him full DVD collection with flash files (about 5.5 Gb zipped files for Chinese models only).
Flash files: we will try to make support area more easy to use. As yopu can see during last days we have made many improvements and we continue.
so for makeing resum u said it will not or can not be done???
for orginizing support folders for chinese phones it will be great step to us .
I just want to say that is you unable to download only one firmware from support area w/o "resume" function you will be unable to repair phones because you never can download all 6 Gb of flash files on your slow connection.


This is my new favorite anime...it has everything you could want. Romance, a fantastic story and even more fantastic creatures. Originally this show was suppose to run for 52 episodes, but due to narrow minded network exec's, it was shortened to 25 episodes...and cancelled. Luckily we at least got a 5 episode OVA out of it. Still, there's a lot of unanswered questions. How unfortunate.
Another superb anime by Bones. This story is truly excellent (excuse mistypes this is via mobile phone) Although older and thus only in 480p its very well drawn and executed. The story itself manages to both entertain and inform, and best of all the damn thing actually has...gasp...a beginning middle and end! I nknow it was cancelled early but they do a decent job ending this. Don't skip it thinking you will be frustrated, I wasnt.
There wasn't a single one of these I felt to be non entertaining. You get another unique mechanic for the hero's "Super power" out of Bones here too. They delve into some of Japan's dirtier history in the Edo period and explain why some things were done that I personally found quite interesting and do it in such a way as to not take away from the quite wonderful face punching.
You get to learn a little bit about how the Japanese language came to be as well which is cool. You get a feel for the maneuverings of the historical figures of the times and they do a nice job of depicting the greys of the times before the black ships. Im not some huge history buff and I didnt get lost in the history telling, it was slipped in nicely.
Ghost Slayers Ayashi is an impressive anime series that was unfortunately stopped before it could become great in my opinion. You can tell how the creators of this series wanted to go in different directions especially in character development and story but unfortunately was unable to do so due to the limited amount of episodes. That being said, it is a wonderful series filled with with a mix of real world history and fiction that will surely please anyone interested in Japanese history or mythology. Also, what I do enjoy about this is that the main character is not your typical teenager/early 20s protagonist as in many anime series, instead he is in his early 40s and the voice actor of this character wonderfully portrays the maturity and gravitas needed for a character of that age. This anime is not well known but I strongly suggest you give it a shot, you won't be disappointed.
This was really quite good.
I had never heard of this one... but I really enjoyed watching it.
The story is about characters wanting only to return to the Other World... death... and they can't enjoy their lives. One thing that keeps them going is the desire to kill and eat beasts from the Other World... it gets complicated as these beasts are gods of the land and people can turn into these creatures from the Other World also like a virus.
It gives or at least hints at a deeper message of people asking what this world is we live in, and if it is better to be dead.
Really interesting story and good artwork. The ghosts or monsters were really cool looking and there were a lot of high action fight scenes.
I think the only issue I can say is that the character designs... it took a long time for me to remember who was who... often characters would look the same.
This was some fabulous, rich storytelling, which tethered its fiction to points in Japanese history. The central protagonist is man who has not been home for 25 years, having been "spirited away" as a youth, he is uniquely gifted and marked to wrestle with how to make peace with his difference. The anime explores the virulent xenophobia of Japan at the time -- killing foreigners and imprisoning any who studied the West - a willful blindness. Amid this roiling turmoil, the cast of characters battle to realize themselves and save civilians from Youi - creatures which eat people, destroy property and wreck supernatural havoc. This has so much to recommend it how did I miss it as it aired? The cast includes requisite young teens, cute girls, a cross dressing priest, a talking horse/dragon, failed samurai, samurai, prodigal sons, but the issues all wrestle with are transcendent: why live and what is your reason for being? The monsters are interesting and there are costs paid for every resolution. There are several story arcs and the idea that there is a power in naming and hidden meaning in the derivation of names is one well worth exploring. Wish the series was able to fully unfold its wings and soar on, but it was a wonderful flight.


Duncan Basheer Hannon Lawyers > Blog > Can I claim compensation if I contract Hepatitis A from contaminated food?
Over recent times, there have been several examples in the media of consumers who have been affected by Hepatitis A, including through the consumption of frozen mixed berries, and more recently, frozen pomegranate seeds which led to the death of a 64 year old Australian woman.
Hepatitis A is one of five strains of Hepatitis (a liver disease), which is contracted when infected faecal matter is ingested. One of the common ways in which Hepatitis A is spread, is through poor hand hygiene. Therefore, there are many examples of people contracting Hepatitis A when consuming foods prepared by people with poor hand hygiene.
Although symptoms of Hepatitis A are treatable, they can cause significant pain and discomfort, requiring time off work. According to the SA Health Topic in relation to Hepatitis A, symptoms can last one to two weeks, or several months in severe cases. In addition, people who have been infected by Hepatitis A will likely have to pay for treatment expenses.
If you have been infected by Hepatitis A, or if you have suffered from any other food poisoning, call 1800 324 324 and speak to one of our public liability specialists for expert advice.


Digital Road Consulting is a web site optimization and pay per click advertising management company located in the Upper Connecticut River Valley of Vermont and New Hampshire. I have an extensive background in marketing and sales in the business to business (BTB) and business to consumer (BTC) sectors, both in product and service environments.
I "discovered" website optimization and ppc advertising in 2001 while researching new ways to promote the website of a company at which I was employed. After weeks of reading, research, experimenting and implementation, I finally saw the fruits of my optimization efforts. The web site rose dramatically in the search engine rankings for tens of keywords and visitor traffic similarly increased. It's been a love affair ever since.
Ultimately, I left that company to launch Digital Road Consulting. DRC began offering commercial website optimization services and pay per click advertising management in 2003. Oddly enough, the amount of reading, research and experimenting have only increased. The evolving nature of the search industry demands it.
Digital Road Consulting's website optimization services and pay per click advertising management are aimed at small and medium size businesses which target English speaking visitors. Because of certain assets, our company is particular well suited for optimization of websites for businesses located in, or targeting, Vermont and New Hampshire. We undertake website optimization and pay per click advertising management for companies looking to reach local, regional, national and international markets.
Digital Road Consulting's website optimization services and pay per click advertising management are performed completely in house. No part of your optimization project is ever outsourced to another company. That means that I'm fully accountable for your website performance in the search engines. When consulting on website optimization projects I'm often asked about also providing website design services. While I do offer website coding and development, I generally contract design work out to a web design company. Additionally, when needed, advanced programming requirements are contracted to more experienced programmers.
Generally, in-person meetings are standard for companies located near the Upper Connecticut River Valley. Meetings can also be arranged with companies located in the same region, although often communication is by email and telephone. Nationally and internationally, business is generally conducted via email and telephone.
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!!! AWARD SUM 6.000 Euros !!!
* What is the particular aesthetic experience opened up by the rise of ubiquitous and ambient media?
* What constitutes the specific intelligence that drives future media environments?
* How will location- and context-aware media services change our social life?
* How will our future lives look like in the era of ubiquitous computation, and how can society benefit from these advanced technologies?
The total award sum for the Nokia Ubimedia MindTrek Award is 6 000?.
The sum can be awarded to one entry, divided between several entries or not awarded at all if the award criteria set by the jury are not fulfilled.
All ubiquitous, pervasive, or ambient media products, services or prototypes which have been finalized during the previous year after 1st January 2010 are eligible to take part in the competition.
Please check out the website http://www.mindtrek.org/ubimedia for entry forms and current information.
The Nokia Ubimedia MindTrek Award is a category of the 2011 MindTrek competition. The category is organized collaboratively by MindTrek, Tampere Region Centre of Expertise in Ubiquitous Computing, New Ambient Multimedia Group (NAMU)/Tampere University of Technology, the Tampere University of Applied Sciences, Nokia, and the Ambient Media Association (AMEA). The award is funded by Nokia and the Tampere Region Centre of Expertise in Ubiquitous Computing. The competition jury consists of wide variety of ubimedia professionals.
All Ubimedia products or product and service concepts which have been finalized during the previous year after 1st January 2010 are eligible to take part in the competition.
An example of a suitable competition entry is a finished product, product pilot or demo. No drafts or mere ideas without relevant documentation will be accepted.
The competition rules do not place limitations on the technology used in the products.
The jury has the right to reject the participation of an entry if it does not fulfill the participation criteria. All jury decisions are final.
A demonstration, production, pilot, or demo is eligible to be submitted to the competition. Each entry should be in form of a video documenting the submission (approx. 3-5 minutes, however also longer videos will be accepted). The video should clearly indicate how the demonstration, production pilot, or demonstration works and relates to ubiquitous media.
In addition to the video, a short English-language based description of the concept should be attached to the competition entry in form of e.g. sketches, images, power points, word documents, or implementations. The description should present the key characteristics and benefits of the product or service in a concise and marketing-oriented manner. In addition, also other materials supporting the jury in their decision (e.g. sketches, images, power points, word documents, implementations) can be attached to the competition entry.
However, the jury decision will primarily be based on the video submissions, and additional materials will be used in case of further questions. We welcome also links to project homepages, but the jury decision can only base the decision on submitted materials.
Registration for the competition ends on 15th June 2011 at 15:00 (+2 GMT).
If the competition entry is delivered to MindTrek via mail, it must arrive at the MindTrek Association?s office in three (3) copies no later than 15.6.2011 at 15:00 (+2 GMT).  If the competition entry is implemented on the internet, its web address must be submitted to MindTrek when registering within the deadline. Late entries will not be accepted.
In addition to submitting the competition entry, participation requires registration using the registration form at the MindTrek website.
Originals sent to the competition will not be returned, so you should keep a copy for your own use. Post and packaging costs are the responsibility of the entrant.
The total award sum for the Nokia Ubimedia MindTrek competition category is EUR 6,000. The sum can be awarded to one entry, divided between several entries or not awarded at all if the award criteria set by the jury are not fulfilled.
The immaterial property rights related to the competition works remain the property of the competitors. The entrants are responsible for ensuring that they have full copyrights to their competition entries and the right to use the works and their elements when participating in the competition.
The material submitted to the award programme remains the property of the author and may not be modified, changed in any way or used in whole or in part for the production of any other work.
MindTrek has the right to use the competition entries and a mention of the entrants as references in its marketing communications.
MindTrek, Nokia and Tampere Region Centre of Expertise in Ubiquitous Computing have the right to disseminate information about the competition arrangements, competition entries, the awarding of the winners and other details related to the competition in their marketing and advertising, e.g. on the web and in brochures and newsletters.
The submitted works may be used by MindTrek without any restrictions or written permission in all presentations, TV broadcasting, CD/DVD productions, CD/DVD compilations and advertisements (internet, CD-ROM, TV, print).
MindTrek has the unlimited right to use the submitted material for distribution on DVDs and other media, especially the right to distribute the video material to labels and broadcasting companies.
The results of the competition category will be announced and the awards presented at the MindTrek Awards Ceremony. The winners will be announced at Hotel Rosendahl on 29.9.2011 at the MindTrek Awards Ceremony. Later on during the MindTrek conference there will also be the Awards Party to honor the winners of the competitions.
Award nominees will be notified in advance. The presence of the nominees at the MindTrek event in October is strongly recommended.
All nominees are invited to give a half day workshop around the ideas of their nominated project in Tampere September 28.
MindTrek will pay travel and accommodation costs up to the sum of EUR 800 per team for a maximum of three invited finalists/teams flying from abroad in economy class. Any Finnish entrants among the finalists will not receive compensation for their travel costs. However, MindTrek will pay for one conference ticket (includes entrance to the MindTrek Awards Party) and one entrance ticket to the MindTrek Awards Party for all finalist teams. MindTrek will not pay compensation for any other possible costs incurred by the entrants due to their participation in the competition.
MindTrek takes place at Hotel Scandic Rosendahl, in Tampere, Finland. The organizer of the conference has booked quota for the conference delegates from this hotel. Please, look for more information on accommodation and registration later from our website. Please note that the accommodation is not included in the participation fee. There is also other accommodation available in Tampere, ranging from modern first-class hotels to smaller traditional hotels and dormitories. If you select one of these options, you should make the reservations by yourself with that specific hotel.


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NOCO is the choice for quality diesel and gasoline products in Brockville. We are dedicated to offering fast and courteous service to suit the needs of your business or farm. We not only provide the highest quality diesel fuel, we also offer a selection of lubricants for a wide variety of machinery and automotive applications. No matter what your fuel needs, NOCO will strive to make sure you have what you need for the success of your business. Our technicians can answer any questions you may have about the right product for your industrial application.
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First, make sure you are using the RS232 cable (shown below in grey) that is labelled 8-0730-04, NOT the 8-0730-05 cable (the 8-0730-05 cable can be set aside for possible future use).
A – Connect the RS232 cable to the "POS Terminal" port underneath the Scanner/Scale.
This contains barcodes used in the final setup.


text:
Hannah Wodecki
Hampshire Softball
Class: Senior
2017-2018 38 12 21 7 0 2 1 0 1
2018-2019 43 21 25 19 0 8 2 4 6
2020-2021 30 13 20 15 12 3 2 3 1
2021-2022 32 8 39 36 25 6 2 6 0
Career Totals: 143 54 105 77 66 19 7 13 8
04/04/2022 @ Minnechaug W 15-3 5 2 4 3 4 — — — — — —
04/12/2022 @ West Springfield W 14-2 3 2 3 2 3 — — — — — —
04/13/2022 vs. Westfield L 4-12 4 1 2 2 2 — — — — — —
04/15/2022 vs. Greenfield W 11-6 5 — 2 3 1 — — 1 — — —
04/18/2022 @ Wachusett L 2-7 4 — 4 — 2 1 1 — — — —
04/20/2022 @ Pittsfield W 9-2 — — 1 3 — 1 — — — — —
04/25/2022 @ East Longmeadow W 19-2 3 3 3 2 3 — — — — — —
04/30/2022 vs. Turners Falls W 19-3 — — 2 — 1 — — 1 — — —
05/02/2022 @ Minnechaug W 13-1 — — 2 3 2 — — — — — —
05/05/2022 vs. Chicopee W 13-1 — — 2 1 2 — — — — — —
05/06/2022 @ Agawam W 3-0 — — — 1 — 1 — 1 — — —
05/09/2022 vs. Greenfield W 11-5 — — 2 — 2 — — — — — —
05/10/2022 vs. West Springfield W 16-4 — — 2 1 2 — — — — — —
05/11/2022 @ Northampton W 22-0 4 — 3 5 1 — 1 1 — — —
05/12/2022 @ Westfield W 11-5 — — — 1 — 1 — — — — —
05/16/2022 vs. Pittsfield W 15-3 — — — 2 — — — 1 — — —
05/18/2022 vs. Northampton W 20-0 — — 3 3 2 1 — — — — —
05/31/2022 vs. Wahconah W 4-3 4 — 2 — 2 — — — — — —
06/06/2022 vs. Uxbridge W 12-0 — — 2 4 — 1 — 1 — — —
Season Totals: 32 8 39 36 25 6 2 6 — — —
2022 Softball Super 7: Westfield, Hampshire highlight list with two recipients each
Hampshire's Hannah Wodecki records 100th career hit in softball game against Wachusett (video)
Softball Scoreboard for April 15: Hannah Wodecki, Teresa Saltis lead Hampshire past Greenfield & more
All-Western Mass. Gymnastics: Selections for 2021 season
Hannah Wodecki hits two-run, walk-off home run to lift Hampshire softball past Westfield, 13-12


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PPC required the Military Command and Hoi An People's Committee to determine the boundary and specific site of the construction, announce contruction site to organizations and individuals concerned, monitor and inspest the construction, fully comply with land procedures and other related regulations. In particular, the construction design must be consistent with the general landscape, ensure transportation of people and tourists, not affect to Cua Dai tourist port.
At the same time, the Military Command and Hoi An People's Committee worked with the Department of Transportation, Hoi An Marine Station and other relevant units on waterway traffic safety. If there are any problems in the implementation process, report to the Department of Construction and the related specialized departments advise the provincial People's Committee to consider and resolve.


text:
Entertainment, News
Meghan Markle Transitioning to Become a Royal
AURN Newsroom
Actress Meghan Markle participates in AOL's BUILD Speaker Series to discuss her role on the television show, "Suits", at AOL Studios on Thursday, March 17, 2016, in New York. (Photo by Evan Agostini/Invision/AP)
A new report out says that Meghan Markle has told her bosses at "Suits" that she will not be returning to USA's hit show next season. The source claims that she will wrap up finishing filming her role in the next month as season seven winds down. Then there is much speculation that an engagement will reportedly be announced around the Christmas holiday.
"Meghan loved playing Rachel and feels she owes so much to Suits," the source explained. "But Harry can't move to Toronto, so she'll have to move eventually if they want to be together."
Rumors have circled the couple for months claiming that the happy couple actually got engaged in August, during Meghan's 36th birthday trip to Botswana. However, there's been speculation that they kept their news secret so as not to overshadow the 20th anniversary of Princess Diana's death.
"Meghan knows she can't really act at the same time as being a princess and is happy to make this career sacrifice," the source told the Daily Star. "She really enjoys her charity work with UNICEF and will broaden out her charity commitments when she becomes a full-time royal."
There is also news that the couple are already looking for their first home in the Cotswolds. Meanwhile, another report claims that figuring out Meghan Markle's new role in the monarchy is already causing conflict within the palace as Queen Elizabeth eases up on some of her responsibilities to make way for the younger royals.
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Biden Wants More Training For Officers
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Real Estate Investors Want Homes in Black neighborhoods
In an unanimous vote, the House passed a bill to…
Senate Republicans blocked a bill to ban discrimination based on…


– rehabs for alcoholics and boarding schools with therapy.
Adult & Teen Challenge's Houston-area Women's campus was established in December 2010. It has 40 beds in a 57,000 square feet facility in Pasadena, TX. Most of the staff leadership are themselves graduates of the program. Men receive room and board, group and individual biblical counseling, parenting classes, spiritual support, relapse prevention, anger management, drug and alcohol education, and social/recreational activities as well as vocational rehabilitation and a sober living for program graduates.
Call (713) 941-2720 to schedule.
We can also help you in your search for other best rehabs, best rehabs, long term addiction treatment centers, or Christian drug addiction programs.
Should you need help finding teen challenge schools, best rehabs, addiction rehabs or Christian drug rehabs, please let us know.


Pete also made many appearances as a side-man. Country/pop superstar LeAnn Rimes has often requested him for her acoustic performances, including the filming of "Live From Abbey Road," a BBC TV series taped at the famous London studios. It aired in America on BRAVO! He also appeared with Rimes on ABC's "Dancing With The Stars" and made an acoustic recording with her that was sold as an exclusive download through Kellog's. He toured with John Denver for the last four years of John's life and often toured with pop icon John Oates of Hall & Oates. Sadly, Pete passed away on January 15, 2016.


text:
Home » Apple
In Apple, Business, IOS, Technology
After shelling out for the latest iPhone, some users are finding the device doesn't perform its most basic function: taking calls. A growing number of users reported that the iPhone X touchscreen [...]
In Apple, Apple TV, gadgets, Google, Streaming, Technology, TV
YouTube's live TV service is now available on Apple TV
Looks like Google is making good on its promise to bring its cord-cutting alternative to more popular platforms. YouTube TV is now available for Apple TVs, after having hit Roku devices earlier [...]
In Apple, Funny, Lifestyle, Like it or Not
Feeling kind of blue today after asking Siri a math question…
"Siri, what is zero divided by zero"? I am curious how long apple will allow this Siri response to survive…
In Apple, Technology
New IOS 8.4 Developer Seed highlights new music features
With iOS 8.3 out the door, it was inevitable that Apple would launch iOS 8.4 in developer preview – and now it's here. The pre-release software ships with a new version of Apple's native iOS [...]
In Apple, Business, Like it or Not, Marketing, Technology
Apple Watch sells out in 6 hours
All Apple Watch models in the US sold out in just six hours, according to 9to5Mac, and shipping time for the devices is delayed by four to six weeks. At the official Apple Watch launch event last [...]
In Apple, Marketing, Technology
Apple Announces Apple Watch Pre-Orders to Start at 12:01am PT on April 10th
Apple today updated the Apple Watch page of its online store to note that online pre-orders for the Apple Watch will begin at 12:01 AM Pacific Time on Friday, April 10. Just after midnight on the [...]
By Managed WordPress Migration User
In Apple, Business, Lifestyle, Technology
Apple Watch in-store reservations begin April 10
Apple on Friday updated its online store with instructions on how to purchase the Apple Watch, reiterating that the wrist-worn device can be ordered online or reserved for in-store pickup. The [...]


Help! Are we having class this week on Wednesday AND Thursday?? Please let me know. Thanks!!!!!
We have class this week on Wednesday only. Dr. Betty Carlson will be speaking on the attachment theory in Chem 200. See you Wednesday and enjoy your Thursday elsewhere.


To ask how deep is not the right question of the blade, but rather, how much moon, if any, is reflected in the silver of your teeth when piercing skin to venerate pink?
She knows who she is, the one who placed a piece of the moon under my tongue when I wasn't looking, now, when I speak of night, light follows, to gild my bated communion.
It cannot be held in tongues, the veering arc of this perigee, ice-hot moon, rounded, throbbing to full, lightly crushing the sea's glittering fount of lace.
Hungry ghosts, gorging, moon-bellied, rending gristle from earthly scavenge— my god, these monsters and their appetites, swallowing illusions whole, to feed empty its runes of fire.


The intensity with which first-time buyers are struggling to get on to the property market means the government should intervene, an expert has argued.
Katy John, of the national campaign for affordable house prices, PricedOut.org.uk, said that availability of mortgages was only part of the solution to the lack of new buyers on the property ladder.
Ms John added that while the body is encouraging people to save in order to get the best deals possible, the government "needs to focus on the longer term objectives of building more houses".
She said the coalition must "[continue] with its planning reforms to free up more land to build on" and ensure that it does not repeat the "mistakes" seen during the last housing market price boom.
Last week, independent financial researcher Defaqto claimed that there is a varied choice of mortgage products on the market that represent significant savings to the consumer, compared to when interest rates were first lowered to 0.5 per cent in 2009.