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Engineering Turbulence – Part II: Lifting The Wright Way!
On July 8, 2019 July 8, 2019 By Tomer Avraham ☇
"It's easy to explain how a rocket works, but explaining how a wing works takes a rocket scientist…" – Philippe Spalart (senior technical fellow – the Boeing company)
The intention of this set of posts is to embark on a journey of connecting the dots between CFD and turbulence modeling with the phenomenological and practical concepts of engineering aerodynamics.
Even though it will by no means be all encompassing nor highly accurate I hope for the essence to be captured, and even more so communicated…
In Part I of "Engineering Turbulence", I have tried to somewhat connect the dots between turbulence and its phenomenological aspects. This will prove very valuable for the description of drag, and especially, to understand how flow control mechanics actually work.
But before turning to control the drag, It is important to actually define and explain notions like lift and drag. Without carrying out an extensive and scientific survey, I would bet that if there were ever an aerodynamic concept that every laymen would like to grasp, it would be how on earth these supremely heavier than air, humongous objects like a 747 are able to carry us from continent to continent without dropping to the ground. Understanding LIFT.
Before trying to control the forces applied on flying vehicles, it is mandatory to define which forces we are actually trying to control. To do that effectively, we resolve the forces in ways which we find most appropriate to the application at hand. In the case of flying vehicles it would be most convenient first to switch into a frame of reference bound to the the flying object, such that the flying object is now considered stationary with the flow driven from the far-field in the opposite direction to what used to be the flight direction in the "real" frame of reference. Then to resolve the component perpendicular to the far-field flow, and call it lift. Again, it is a matter of convenience to resolve the force in that manner such that the lift would generally be the force countering gravity and/or providing maneuvering forces for our flying objects (it may be responsible to a whole different kind of concept when encountered in sails for example, but we are focused on flying now… 🤓).
Ingredients of Lift
In essence we could claim that lift is described by a solution to Navier-Stokes equations. This sounds somewhat a little too obvious and somewhat unsatisfactory though. It's not even much of an explanation but more as an agreed upon fact, and most importantly, it doesn't improve our understanding of how lift comes about.
We may also claim that something like the "Kutta–Joukowski theorem" which relates the lift to the circulation around the airfoil, provides a good explanation for lift. But again, this also amounts mostly to jargon and math, and in any case shifts us from explaining how lift comes about to explaining how did the circulation got there… We would like a simple, yet more complete way to explain lift once there.
The ingredients for our lift explanation then, shall be as follows:
A lifting-surface (or airfoil) in a certain range of an angle of attack such that lift is produced.
A fluid which flows as a continuous material, deforms to follow the airfoils shape, affects the direction and/or speed and at the same time the pressure field in the flow, and it does so in a wide, yet "confined" region around the airflow.
A reciprocal 2-way cause-and-effect relationship between pressure difference and velocity.
Airfoil and the Angle of Attack
A lifting surface shaped as in the figure below is called an Airfoil. Although some airfoils could be much more effective than others, almost any shape of an (not too thick) airfoil would produce lift when the angle of attack (AOA), being positive when the front of the lifting surface (leading edge) is above its back (trailing edge), is in a certain range.
Here are some examples of airfoils oriented to the far-field incoming flow such that (as long as the flow is mostly attached) lift is produced:
As you may evidently see, the shape of a lift producing airfoil may even be a flat plate, and as we will soon see, such a shape somewhat removes the rug under lift explanations such as "Longer Path Equal Transient Time", as described in the figure below (taken from Wikipedia which actually presents this explanation as a fallacy, then follows by providing a somewhat incomplete simplified lift explanation of its own), actually flawed in more way than one (there's also a nice explanation from NASA as to this incorrect lift theory).
In essence, there is no reason why fluid parcels that split at the leading edge must rejoin at the trailing edge. When we choose to track fluid parcels (outside the immediate boundary layer), we find that under lifting conditions, parcels that traverse the upper surface make the trip in less time and get to the trailing edge before the corresponding parcels that traverse the lower surface. Parcels that started close together near the attachment streamline ahead of the airfoil end up permanently displaced from each other after they pass the trailing edge.
Even if it weren't wrong, simply saying that a fluid parcel must go faster than another originating from some location to get to the back of the airfoil at the same time does not explain why it goes faster (and changes direction all along), for example, by identifying a physical force that accelerates it to a higher velocity (and forces changes to its direction).
Newton's Third Law: for every (force) action there's an equal and opposite (force) reaction
When the airfoil shape is in a lift producing AOA range, the airfoil pushes downward on the fluid which pushes back with an equal and opposite force in the downward direction. This is lift.
The reason for the fact that a push back occurs is of course Newton's third law, stating that for every (force) action there is an equal and opposite (force) reaction. Meaning that lift is an interaction in which the airfoil and the fluid exchange equal and opposite forces.
What is the Push?
Fluids always pushes against themselves, and against every surface they interact with. This push is Pressure. So when an airflow is surrounded by a stagnant fluid, the pressure is, for all practical purposes, the same everywhere, and the push downward on the airfoil's top surface, and upwards on the airfoil's bottom surface is the same, the integrated forces due to this exerted pressure is zero, and there is no lift. When the fluid is moving, and the airfoil is in a certain range of AOA, the integrated forces are such that lift occurs, it is then directly due to a pressure difference which comes about as (on average) a higher than ambient on the lower surface (usually), and lower than ambient on the top surface (always).
How Does The Push Comes About?
Fluid flows as a continuous material. I have somewhat explored this shift from the molecular view to the continuum in Engineering Turbulence – PART I: Phenomenology. Do to this continuum view, the fluid appears to be gradually deforming around an airfoil such that it follows its contour, but also the flow keeps being affected on a wide area, producing pressure changes predominantly in a somewhat "confined" region, such that when lift is produced there is always a confined (but not sharply) region of lower than ambient pressure above the airfoil, and there is usually a confined (but not sharply) region of higher than ambient pressure below the airflow.
Pressure and velocity fields for an AOA of 7° NACA 0015 airfoil
This (non sharp) "confinement" in both horizontal and vertical directions of the pressure difference is a critical for the "push" to come about. When a (small) fluid parcel with a (small) mass is passing along somewhere in this "confined" region over the top or below the bottom surfaces of the airfoil it interacts directly with other fluid parcel's which exert a net force on it through the differences in pressure. The forces pushing on the fluid parcel are not balanced since the pressure on one side of the fluid parcel is higher than on its other side. This is Newton's Second Law in action, according to which if a net force is imposed on a fluid parcel it must cause a change in its speed and/or direction.
So there is also a confined effect on the velocity field, such that besides the deflection downwards of the fluid, the flow on the upper and lower surfaces speeds up, and slows down. This speeding up and slowing down is also confined, and fades further away from the airfoil.
The figure below illustrates for the (lift producing) NACA 0015 airfoil in a 7° AOA how these fluid parcels would be acted upon by the pressure field in the "confined" region. The arrows are of the net force exerted on such parcels, and it is easy to see that whether above or below the airfoil, fluid parcels see a higher pressure above than below them, hence a net force which is mostly downward.
We can also see the flow is entering above the airfoil the "confined" region of a lower than ambient pressure with a net force from left to right (as the arrow shows) which will speed it up, then exiting on the other side of the "confined" region, where the pressure difference is in the opposite direction (and hence so is the net force), which will slow it down.
The reverse sequence is seen for the flow entering the "confined" region below the airfoil. A fluid parcel passing through a higher than ambient pressure, is slowed down and then speed back up. This description is actually the Beroulli's theorem, and since it applies to regions of steady-flows which are not affected significantly by viscous effects (e.g. friction), we should add that this description is valid in the "confined" region I've described, but predominantly outside the boundary layer).
reciprocal cause-and-effect relationship between pressure difference and velocity
Already by looking at Navier-Stokes equation we see that both pressure gradients and the velocity fields are coupled, and there is no 1-way causation arrow between them in either direction. And indeed, as explained in the above paragraph, the pressure difference in the "confined" region causes a change in the fluid parcel's direction and speed, and, at the same time, the resistance of the fluid parcel to this change in speed and/or direction sustains the pressure difference. Or in other words:
The pressure differences cause the flow to change speed and/or direction.
The change of speed (acceleration) and/or direction of the flow + its inertia causes the pressure differences to be sustained.
In sum, because the fluid is a considered a continuous material it appears to be gradually deforming around an airfoil, and it keeps being affected on a wide , yet "confined" region around the airfoil, producing pressure changes this "confined" region. When the airfoil is a certain range of AOA such that there is always a confined (but not sharply) region of lower than ambient pressure above the airfoil, and there is usually a confined (but not sharply) region of higher than ambient pressure below the airflow, then the airfoil pushes downward on the fluid which pushes back with an equal and opposite force in the downward direction (in accordance with Newton's third law).
At the same time, these pressure differences in the "confined" region exert a net force which is mostly downward on the flow (in accordance with newton's second law) such that it changes the speed and/or direction of the flow mostly downwards.
These pressure differences also act in the horizontal direction, speeding up or slowing down the fluid in a mechanism formally described by the Bernoulli's theorem.
The change of speed (acceleration) and/or direction of the flow along with its its inertia causes the pressure differences to be sustained completing a 2-way cause-and-effect reciprocal relationship between pressure difference and velocity.
This concludes Part II of the "Engineering Turbulence" series. In Part III: "What A Drag!" , the concept of Drag shal be somewhat explored and explained, along with its reduction by flow control methodologies which are based on certain fundamental aspects of transition and turbulence coherent structures.
Engineering Turbulence – Part I: Phenomenology


1. All TA members may join. Membership is voluntary, and members may leave the scheme at any time.
The scheme does not include public transport or use of other products and services as there is no easy way to calculate these contributions.
3. The scheme is based on emissions per adult person, not households.
4. Members will supply the following information to enable their CO2 emissions to be calculated.
Number of adults in household. Use fractions for part occupation eg if an adult is present 6 months of the year, count as 0.5 adults. Children under 18 count as one third of an adult.
Gas and electricity meter readings at 1 Jan 2012 and 2013.
No reductions or adjustments are allowed for a renewable or green electricity tariff. See note 1.
Domestic generation of electricity is offset against consumption.
Air travel. To find out emissions from air travel, members need to use the air travel calculator on the Climate Care web site (http://www.climatecare.org/), entering the flight start and end locations. Business flights are excluded, in line with other business travel..
Personal car or motorbike mileage, fuel (diesel or petrol), and average mpg. This requires members to record the odometer readings at 1 Jan 2012 and 2013, and to calculate their average mpg by recording the quantities of fuel and miles travelled over a few months.
Alternatively, and more accurately, members may record all their fuel purchases during the year. A year-end adjustment is in theory appropriate but we can manage fine without it.
If a car is shared, members need to either record the mileage when they are driving, or simply estimate the fraction of the total miles that are attributable to them (see note 2). Travel to and from normal place of work is included, but other business mileage, including self-employed person's business mileage, is excluded. Alternatively members may record the volumes of fuel bought over the year and allocate it to business and personal use.
Ideally all taxi and car-hire use for non-business purposes should be recorded too. You should record the mileage of each journey (The AA website is useful for saying how far it is from A to B), and, if shared-use, the number of people in the vehicle). Great accuracy isn't necessary, estimating the distance to, say, the nearest 50 miles is adequate. For hired cars you can instead record the fuel volume bought and that gives a better estimate.
6. The embodied carbon in food is estimated using the following values.
9. At the start of 2012, members will report their meter readings and if appropriate odometer readings to the PCF scheme administrator, currently Tony Cooper.
10. At the end of each year, the members will report their consumption figures to the PCF administrator who will calculate and record their CO2 emissions from the data provided. A small prize will be awarded for the member with the lowest emissions, and, starting in year 2, another for the biggest reduction in emissions.
11. If people want, to maintain interest during the year, they may report quarterly figures. I find that helpful, but it isn't essential.
1. No reductions are allowed because unfortunately there is no way of clearly demonstrating the reduction is emissions (if any) that arises from switching to a green tariff. Despite this we still want to encourage people to select a good green tariff. The following are recommended by most surveys: Good Energy, Green Energy and Ecotricity. This position should be kept under review if possible.
2. For example suppose a shared car does 10000 miles per year. A drives 1000 miles alone, B drives 4000 miles alone, 5000 miles is shared. Miles attributable to A is 1000 + 5000/2 = 3500. Miles attributable to B is 4000 + 5000/2 = 6500.
3. These figures are a rough approximation, provided by the Green Mole Forum. It's hard to find a reliable and comprehensive source for food emissions, perhaps because it's a complex issue. There are many plausible sources with partial data and further references. I hope to investigate further but this will take time. Clearly if one changes one's overall diet category partway through the year, the final figure is an appropriate average.
4. A low meat diet means at least three meatless days per week. Fish counts as meat.


As I mentioned in an earlier post, my musical focus this summer has been on writing a concerto for tabla and percussion quartet, for tabla artist Shawn Mativetsky and members of the New Jersey Percussion Ensemble. I undertook this project along with five other composers who wrote concertos of approximately 8 minutes each, as part of the Shastra 2018 summer workshop organized by Payton MacDonald. It has been a wonderful experience in every way.
My goals for this first movement were quite specific. I wanted to explore how material from a traditional tabla composition or kaida could be shared by a four-player percussion ensemble. The idea is that that other instruments in the ensemble — cymbal, bongo, marimba, vibraphone, glockenspiel, bass drum, tam tam — should each focus on a certain aspect of the tabla part and echo it, reflect it, or otherwise imitate it.
I should note that the idea of playing tabla material on an instrument other than the tabla is not new. All tabla compositions can be recited vocally using syllables that refer to specific strokes or stroke combinations — this vocal recitation is a central part of traditional tabla practice. Moving beyond tradition, percussionists like Pete Lockett and Dan Weiss have experimented with mapping each of the individual tabla strokes or bols to the Western drumset. However, I had a four-player percussion ensemble to work with and I wanted to go beyond merely translating the tabla part to one other percussion instrument.
One way I could have approached my piece is to take a long, fully-composed tabla solo and assign each tabla stroke to one of the ensemble instruments, thereby creating a direct orchestration of the tabla solo. For this piece, however, I took a different approach as I wanted to leave room for a more creative interplay between tabla and ensemble. Instead of trying to orchestrate an extended tabla composition, I took a short, four-bar composition as my seed material. The piece begins with the tabla stating this four-bar composition, after which the tabla player is free to improvise variations on the seed. As the tabla player goes on improvising variations, the ensemble echoes different aspects of the seed itself, staying true to its original form. This means that the outcome of the piece is quite dependent on the tabla player's improvisational choices. When the tabla player creates a variation that differs markedly from the seed, the tabla part will seem to contrast with what the ensemble is doing; but when the tabla player restates the seed or creates a variation that's close to its original form, the tabla part will seem to be in sync with the ensemble.
Neither I nor tabla soloist Shawn Mativetsky were sure how well this would work before we got to the rehearsals, but it turned out to work better than expected. Shawn told me that as he played, he found it interesting to hear the "shell" or "skeleton" of the kaida continuously echoed by the ensemble. He said that the oscillation of being in and out of sync with the ensemble, as he played closer and more distant variations on the kaida, added a level of variety to the piece which kept it interesting.
Another point to note is that the ensemble in this piece consists of melodic instruments like marimba, vibraphone, and glockenspiel along with purely percussive instruments like cymbal, tam tam, bongo, and orchestral bass drum. In writing the piece I faced the question: How does one create a melodic interpretation of a purely rhythmic composition? How to introduce pitch in a way that emphasizes the character of a rhythm rather than distracting from or overtaking that character? I had begun to think about these questions in working on my earlier percussion piece Escher's Drum. With Escher's Drum, the melody came about in an expected way when percussionist Gavin Ryan chose to perform my purely rhythmic parts on pitched gamelan instruments; with the current tabla piece, I wanted to "melodize" the rhythm in a more deliberate way. The result can be heard in the repeating riff played by marimba and vibraphone.
The piece begins with a kind of fugal introduction, where the tabla part first states the kaida, and then the cymbal enters, imitating the tabla's na strokes. Next the bass drum enters, imitating a different aspect of the tabla composition, the resonant bass strokes ge. Next the tam tam can be heard to double the tabla's tun stroke. (This was an aspect of the piece I was unsure about: the tam tam has a long sustain even when the player attempts to mute it, while the tabla's tun stroke is quickly muted by subsequent strokes. Would the tam tam's tail be too long? In fact I think it worked out fine, as the tail creates a kind of textural mass that's welcome in the piece.) Next the vibraphone enters, doubling the tabla's na strokes as the cymbal had begun doing earlier. And then the marimba enters, playing a riff that aims to interpret the tabla part melodically. The vibraphone joins the marimba in this effort and eventually they play in canon. Later the glockenspiel enters, imitating the tabla's na strokes mostly on a single note, but with bits of melody suggested. Then the bongo enters, trying to copy the tabla part as closely as possible, while the tabla moves to an accompanying role, the cymbal switches to a contrasting rhythm, and the vibraphone plays a chordal vamp. In the final part of the piece we hear the glockenspiel play a cadential melody three times, in dotted quarter notes, with the final statement skewed so that the last note aligns with the final rhythmic accent on the sam of the teental cycle.
A number of things about this piece worked better than I expected in live performance, including the improvisational freedom in the tabla part that led to that part being in and out of sync with the ensemble, and also the sustained tam tam strokes that added textural mass. What didn't work as well as I imagined? For one, I expected a greater timbral contrast between the marimba and the vibraphone, and I was depending on this contrast to create a sense of variety as the shared "riff" is stated many times by both instruments in the opening sections. In the recording, there's less timbral contrast between the two instruments than I'd like, and so I feel the statements of the riff can seem too repetitive. I'm not sure this is a compositional problem though; it could probably be "solved" by a different recording technique along with contrasting mallet choices for the vibraphone and marimba parts. The present recording was made from a distance with a pair of AEA N8 ribbon mics in a Blumlein stereo configuration. If I could do it over again I'd move the marimba and vibraphone closer to the mics, or if even more luxury was afforded, I'd add add additional mics to isolate each of those instruments, and I'd then bring them forward in the mix so their individual characters could be heard more clearly.
The third movement of the concerto explores how a percussion ensemble can join the tabla in a traditional cadential composition or tihai. We would have needed a little more rehearsal time during the 2018 Shastra session to get a good recording of this third movement, but I'm delighted to have such great rendering of the first two movements, and I hope to continue writing for tabla, to continue collaborating with the wonderful folks at Shastra, as well as with anyone else who might be interested to join me in similar cross-cultural musical explorations.
My photography from the 2018 Shastra rehearsals can be seen here.


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Q: PHP Javascript Web Page Sync using cookie I have a web page to be created that will read data via serial port which needs to be updated in a web page. My approach is to have a PHP script that will monitor in an infinite loop of incoming data from serial port. Once received it would just update a cookie . The web page will read the update cookie and update its content.
Is my approach possible to implement? I am not sure how to sync a cookie by name both from PHP and Javascript - one does not read until other finishes writing.
<?php
setcookie("user", "My Name", time()+3600);
?>

Now in a web page at setInterval method I need to read the cookie.
function getCookie(cname)
{
var name = cname + "=";
var ca = document.cookie.split(';');
for(var i=0; i<ca.length; i++)
  {
  var c = ca[i].trim();
  if (c.indexOf(name)==0) return c.substring(name.length,c.length);
  }
return "";
}

getCookie("user");

Now that I have cookie data I can update the web page by calling reload() JS method.
Is my approach correct - will this approach work - what are the things I should take care?

redpajama_set_name: RedPajamaStackExchange


text:
package com.pdsl;

import com.pdsl.api.*;
import com.pdsl.component.ComponentSuiteTest;
import com.pdsl.uat.UserAcceptanceTestSuiteTest;
import com.pdsl.unit.GherkinTagFiltererTest;
import org.junit.runner.RunWith;
import org.junit.runners.Suite;

@RunWith(Suite.class)
@Suite.SuiteClasses({PolymorphicDsl.class, GherkinTagFiltererTest.class,
        //InterpreterBasedPhraseFilterTest.class, //TODO: finish this feature then enable it
        ComponentSuiteTest.class,
        ApiSuiteTest.class,
        UserAcceptanceTestSuiteTest.class
})
public class FullPolymorphicDslTestSuite { }

redpajama_set_name: RedPajamaGithub


Kingman hosted the International Route 66 Festival in 2014. Photo from the City of Kingman.
Caption: Downtown Kingman. Photo from City of Kingman.
Visitors and residents alike have been enjoying the historic architecture, community events, and businesses in Kingman's revitalized downtown. In 2014, Kingman hosted the International Route 66 Festival, which brought 8,000 attendees from 24 different counties to downtown to celebrate the historic road. This year Kingman combined the celebration of Route 66 and classic cars with its love for rodeo in the Inaugural Best of the West on Route 66 Festival September 25 -27.
Kingman Club. Photo from City of Kingman.
In addition to public events, two event centers have opened in previously vacant historic buildings and are available for private parties, weddings and community fundraisers. The success of events in historic downtown could not have taken place without many improvements, beginning with the elimination of non-emergency train whistles. The reduction in noise also led to the opening of several new businesses including a boutique hotel, restaurants and bars. Beautification projects including ADA compliant upgrades and repairs to the sidewalks, park improvements, and abatement projects have helped create a welcoming atmosphere to compliment the area's growth.
Caption: Hilltop Motel in Kingman. Photo from City of Kingman.
Posted on October 2, 2015 by League Staff in Arizona's Downtowns | Tags: Arizona Cities @ Work, Arizona Downtowns, City of Kingman, Colorado River, Historic, Kingman, Route 66 | permalink.


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Crumble or The Cookie Gets It
In what has to be one of the most bizarre ransom stories ever told, police in Germany are on the hunt for a golden cookie believed to have been stolen by a man dressed as The Cookie Monster. This is not a joke.
It all started a few weeks ago when police in Hannover were informed that the famous golden biscuit outside the German baker Bahlsen's was stolen. The company is a big employer throughout Germany and has supplied biscuits for around 120 years, the Golden cookie stood as a testament to this work.
At first there were no leads as to who had taken the cookie but that all changed when a local Newspaper in Hannover received a picture and ransom note.
The thief, dressed in a Cookie Monster costume, has made certain demands for the cookie's safe return. In a ransom note written using cut out letters they began by saying, ""I have the cookie! And you want it."
The note also went on to say that if Bahlsen's doesn't supply treats, specifically milk chocolate cookies, to all the children at the local hospital ward they will never see their golden biscuit again.
Is it Safe To Eat Raw Cookie Dough?

redpajama_set_name: RedPajamaCommonCrawl


One of the most impressive outdoor activities is; Canyoning. Canyon is originally a Spanish word (cañón) meaning 'narrow gorge'.
Canyoning is the descending into a gorge where water is flowing through it. 'Walking, swimming, climbing, sliding, jumping and descending on rope to make a trip through the canyon ' (Tempe, 2011).
A canyon is a huge play area for young and old. Children from the age of 6 can have loads of fun, while the adults pushing their boundaries, with abseiling, big jumps and natural water slides! The fantastic surroundings and the image of nature is what makes canyoning always so incredibly cool!
Via Ferrata is Italian and, in English, means in English ' iron way '. Sometimes it will be called ' klettersteig '.
Via Ferrata can be seen as a mountain hike and climb together. A Via Ferrata route is secured with steel cables that are consolidated in the rocks to which the mountaineer can attach themselves.
In addition to the steel cables, on more difficult and steeper passages, there will be other elements to it, such as stairs and bridges. By using these elements you can reach certain spots that you wouldn't be able to achieve just by hiking.
Via ferrata's come in different categories. From easy (for children and beginners) to very difficult (for advanced).
In the region of 'la Terra Alta ' is the famous cycling route: Via Verde, meaning the 'Green Road'. A perfect bike route where you can spend hours of cycling through the magnificent landscape and many old railway tunnels.
It's possible to rent mountain bikes and more comfortable bikes at Ebroasis. Transportation to and from the Via Verde is available if required. There are multiple start and end points but most recommended is to start at Benifaillet. The route from Benifallet to Horta St Joan is slightly ascending.
You can choose how long you want to go cycling for. One thing is guaranteed: it is a beautiful cycling route!
• Mountainbike: € 20,- p.p.p.d.
With climbing and abseiling you need strength, insight and determination. The trick is to keep the body in balance and use the power from the arms and legs.
When climbing there is no fixed route. The ideal route depends on the length of the climber, weight, personal preference and the size of the grips.
In the beautiful climbing area of Tivissa, there are over 500 different climbing routes suitable for young and old.
Canoeing is one of the most popular outdoor activities done on vacation. Also Ebroasis Fishing & Outdoor offers the possibility to enjoy a morning or an afternoon with the whole family to go canoeing.
With Ebroasis Fishing & Outdoor you can go canoeing on the well-known River Ebro. Equiped with the famous Sit On Top canoes, you'll take the challenge of fast flowing river canoeing or a more sedate drifting Canoe trip. The choice is yours.
Spend a morning or an afternoon enjoying the Sun on the river!
For more information and / or reservation contact us mailen.


With Transformers: Age of Extinction seeing it's release this summer sci-fi and comic book fans will be aching to get their hands on the latest gear.
Both children and adults will be the envy of all their friends in our new Transformers fancy dress outifts. Whether you fancy yourself as the great leader, Optimus Prime or the heroic Bumblebee, we have the perfect fancy dress costue.
Suit-up and transform into your favourite cartoon character with these costumes, brand new for 2014.


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Who Knew? Never Blow Your Nose When You Have a Cold
[via nytimes]
Blowing your nose to alleviate stuffiness may be second nature, but some people argue it does no good, reversing the flow of mucus into the sinuses and slowing the drainage.
Counterintuitive, perhaps, but research shows it to be true.
To test the notion, Dr. J. Owen Hendley and other pediatric infectious disease researchers at the University of Virginia conducted CT scans and other measurements as subjects coughed, sneezed and blew their noses. In some cases, the subjects had an opaque dye dripped into their rear nasal cavities.
Coughing and sneezing generated little if any pressure in the nasal cavities. But nose blowing generated enormous pressure — "equivalent to a person's diastolic blood pressure reading," Dr. Hendley said — and propelled mucus into the sinuses every time. Dr. Hendley said it was unclear whether this was harmful, but added that during sickness it could shoot viruses or bacteria into the sinuses, and possibly cause further infection.
The proper method is to blow one nostril at a time and to take decongestants, said Dr. Anil Kumar Lalwani, chairman of the department of otolaryngology at the New York University Langone Medical Center. This prevents a buildup of excess pressure.
Blowing your nose can create a buildup of excess pressure in sinus cavities. [photo: flickr]
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You are here: Home / Blog / Monthly CRM News / October Monthly CRM News
6 min readOctober Monthly CRM News
Monthly CRM News, Uncategorized
Microsoft Dynamics 365 Grand Unveiling
This month, Microsoft began to bring their Partner Network up to speed with the highly anticipated Azure Cloud hosted Dynamics CRM and Dynamics ERP combo. It's the first time we've seen the Common Data Model used to such great effect joining business processes with business productivity in a way that not only creates one big feedback loop for insight, but also licensed the way that many of our customers will be thrilled to be able to buy.
The final launch is set for the 1st of November. Our MD Billy Lyle has a countdown on his calendar and time set aside to get stuck into the workings of the system. Because of the way we like to service our clients, the whole team will be reviewing how the new features and capabilities are going to benefit each of our clients, existing and new.
Writing over the weekend, Billy said "This isn't just an upgrade. It's going to make Dynamics 365 the most comprehensive and user-friendly business productivity platform in the category. For our existing clients, there is huge opportunity to have ERP, CRM, Business Intelligence and productivity tools such as Outlook and Excel all working on a single platform. Imagine the insight you will be able to get into your business when your full team can see all interactions with the customer from one single location. This will mean that the full team is empowered to deal with the customer in the best possible way. Management can also get there KPIs real time with the granularity needed to know exactly what to do to continue an up surge and, to stop any negative trends quickly and effectively. That's just the tip of the iceberg of what this level of integration can do.
We'll have more information soon but if you can't wait that long you can read our FAQ document from earlier this month or watch our webinar Introduction to Dynamics 365.
What about Microsoft Dynamics CRM?
CRM Online
Whilst, CRM Online will cease to be available for new implementations as of the 1st of November, existing CRM Online customers can continue as normal. Your Dynamics CRM is safe. You can continue to add new users under the CRMOL and AX SKUs until renewal. You will also have transitional prices you can transact for Dynamics 365 SKU's. If you are at renewal already, you will transition to 365.
On-Premise Customers
If you're On Premise, you won't be forced to move to Cloud, nor will you find yourself unsupported. Microsoft has committed to continue developing and supporting the on premise versions of Dynamics AX and CRM for the foreseeable future.
And if you're considering moving to Cloud? Talk to us and let's see how 365 compares to how you're currently doing things. What we can tell you is there will be a 40% Customer Cloud Transition discount for On Premise customers who purchased their licenses before 31.10.16 and that will remain open until 1.11.19. The discount is called a "Cloud Add On' which means you need to have an active enhancement plan or software assurance.
UK Data Centres
Back in September, Microsoft Cloud brought its cloud locality commitment to the UK. It's in response to UK requirements for local data storage to enable UK back ups and UK legal compliance and has already secured the business of The UK Ministry of Defence, Aston Martin and the South London and Maudsley NHS Foundation Trust. The Cloud focus appears to be paying off with Microsoft shares at a new high.
Ever wondered what a data centre looks like? We don't have footage of the new UK one yet but here's what one looks like from the inside:
The Next Generation of Humans:
HP and Microsoft have paired up to transform how technology is used in schools. The three UK schools that are part of the project will use Learning Studios to "reinvent the classroom as a space for students to design, create and invent through innovative technology.
Using Skype, Microsoft Office 365, Microsoft OneNote and Office Sway, pupils will build a variety of skills, including design thinking, 3D design, visual communication, invention literacy, digital storytelling and social entrepreneurship. They will also be encouraged to foster greater collaboration with teachers, afterschool programme leaders, administrators and parents, who have all been encouraged to play active roles in the learning experience. Their schools will be provided with ongoing training, support, resources and evaluation as well as the technology.
Linkedin Acquisition
Here's what we might see from Microsoft's $26bn purchase of LinkedIn:
Single sign on for CRM and LinkedIn – Single sign on already exists for Office 365 and Dynamics CRM Online so it makes sense to include LinkedIn.
Sales Navigator Integration with CRM – the lead and contact discovery tool will most likely feature in the integration.
Contact Discovery & Data Cleansing – Imagine a world with intro requests from the CRM Interface, being able to import LinkedIn contacts into CRM, discovering other contacts at the same organization, keeping CRM data content current. E.g. job title as people move around.
HR Integration – enabling teams to discover and research candidates then manage the relationships within the CRM. For existing employees, it will be easier to keep employee profiles in line with brand where required.
Messaging – Instead of email, CRM users might be able to send messages to LI contacts and track the interactions in Dynamics.
Social Engagement – we hope to see the LinkedIn API opened up to up Microsoft's Social Engagement game yet another notch.
What's being said about the acquisition:
""I'd do everything differently, but this goes into the category of 'you can't win them all," Marc Benioff, Salesforce CEO
"Just as we have changed the way the world connects to opportunity, this relationship with Microsoft, and the combination of their cloud and LinkedIn's network, now gives us a chance to also change the way the world works," LinkedIn CEO, Jeff Weiner stated in Microsoft's release.
In other Tech news…
There was much speculation that Salesforce would buy Twitter but CEO Marc Benioff has now told the FT it's officially off the cards.
AI has had a fair few headlines with Stephen Hawking naming it as either the best thing or the worst thing to happen to humankind. AI and Machine learning are often confused – read more about it in this Wired article.
Facebook is now reported to be taking on food ordering, event ticketing and more in an effort to grow the 'stickiness' of its platform.
We saw Google admiring retool Apps for Work and Apple leveraging its relationship with IBM. Facebook are reportedly soon launching their business focused Facebook at Work. Everyone is suddenly very interested in the Enterprise market (that's all of you) but all of these advances still don't get them anywhere near Microsoft's level which is more accessible than ever with the Dynamics 365 pricing approach.
If there's anything you'd like to hear our views on, or particular tech info you'd like to see on our site or on social, let us know and we'll try our best to include it.
Redspire https://redspire.co.uk/wp-content/uploads/2017/05/Black-Writing-with-Transparent-Background.png Redspire2016-10-28 08:53:002017-09-13 15:02:05October Monthly CRM News
Why Insurers Choose Microsoft Dynamics CRM for Customer Retention Are you preparing your data for Brexit?


text:
Jim Dickrell
National Dairy Shrine museum, Ft. Atkinson, Wis. ( Farm Journal, Inc. )
Source: National Dairy Shrine
National Dairy Shrine is again seeking nominations for the dairy industries most prestigious recognition awards: Guest of Honor, Pioneer, and Distinguished Dairy Cattle Breeder.
The Guest of Honor is given to an active contemporary dairy leader for outstanding accomplishments and contributions to the dairy industry. It has been awarded every year since 1949 when Dean H. Kildee was named the first Guest of Honor.
Also each year, three to four living or deceased dairy leaders are honored as Pioneers by National Dairy Shrine for their service and leadership in the dairy industry.
Additionally, the Distinguished Dairy Cattle Breeder is an award which recognizes active, progressive dairy producers who, through their expertise in managing a dairy breeding herd based upon sound genetics and business principles, serve as a model of success for fellow breeders throughout the country.
All these award honorees portraits and accomplishments are on permanent display in the National Dairy Hall of Fame at the National Dairy Shrine Museum in Fort Atkinson, Wisconsin.
Nominations or applications must be submitted on official forms by March 15. If you know someone who should be nominated for these awards, please visit the NDS website at www.dairyshrine.org and click on "Awards" and then "Adult Applications" to view a complete listing of each award form. Then you can download the application for the respective award desired.
The annual National Dairy Shrine awards banquet will be held on October 1, 2020 in Madison, Wisconsin. For more information please contact the National Dairy Shrine Office at [email protected]. National Dairy Shrine membership information is also available online at www.dairyshrine.org. Dairy enthusiasts are encouraged to become a part of this important dairy organization to help honor our dairy heritage, inspire future leaders and promote the dairy industry.
Related on Dairyherd
January 21, 2020 by Taylor Leach
January 20, 2020 by Washington State University
Trending in Dairy Herd
Dairy Markets Continue To Rally In 2020
Could Dairy Be a Big Winner in the Phase One Trade Agreement?
Milk Markets Bounce Higher


Today, innovative employers are offering whole health solutions like Accolade to simplify and personalize the health and benefits experience for employees and their families. Join Accolade CEO, Rajeev Singh and other industry leaders as they discuss why caring for the whole person, not just a condition is better for employees and better for business.
The 2018 IBI Annual Forum will convene more than 500 employers, suppliers, and other thought leaders to explore innovative solutions to the myriad challenging and ever-evolving issues in the health, wellness, and productivity space. The Forum offers plenary and breakout sessions, discussion panels, tools labs and several networking opportunities to bring like-minded professionals together for a common goal: improving the health, well-being and performance of America's workforce.


Made by my sweet husband, Mike Goyette. A handsome, small board made of white oak, made black with a natural, food-safe iron liquor.
6 1/4" x 6" x just under .75". Included is a tin of our Beeswax Wood Balm.
Please never soak your wooden utensils in water. Wash with soap and water, air dry, wax often. To preserve the black finish, please minimize contact with acids, leaving cut lemons etc. on the surface.


text:
Serving Clients Throughout Ohio 937-403-9033
Nancy L. Jillisky
Michael J. Streng
Matthew A. Weller
Amy E. Gullifer
Kimberly M. Cutler
Adam L. Davis
Former High School Cop Guilty Of Sex Charges
By Cannizzaro, Bridges, Jillisky & Streng, LLC
A seven-year prison sentence has been meted out to an ex-police officer accused of committing a sex offense while assigned to a Columbus, Ohio, high school. Prosecutors asserted that he had compelled two 15-year-old female students at Centennial High School to begin sexual relations with him. He was assigned to work at the school as a resource officer in 2012.
The 50-year-old male ex-officer entered into a guilty plea earlier in the year. His arrest came at the culmination of an FBI investigation that reported that he had sent and received messages with the girls on Facebook and through text messages. He purportedly asked the girls for help with what he said was his addiction to sex.
After he serves his prison sentence, he will also have to remain under house arrest for an additional year, followed by supervised release for a period of five more years. The federal judge also imposed a $20,00 fine. As a consequence of the conviction, the defendant will be mandated to comply with lifetime sex registration requirements.
The offense for which he was convicted actually has a minimum prison sentence of a full decade in prison, but his sentence was reduced because of his reported cooperation with other unspecified ongoing FBI investigations.
One of the girls reported that she carried out an oral sex act on him in the high school auditorium while a play was being presented. He was in his police uniform at the time, according to her account, and also wearing his gun belt. The potentially lengthy prison sentences and harsh impact of lifetime sex offender registration renders it vital that anyone facing accusations of a sexual offense consult with an experienced criminal defense attorney at the earliest possible time.
Source: The Columbus Dispatch, "Ex-school cop gets 7 years for sex abuse" Ryan Clark, Jun. 28, 2013
What Are the Differences Between a Chapter 7 Bankruptcy and a Chapter 13 Bankruptcy? Mar 04
When making the decision to file for bankruptcy, it is important that you thoroughly understand your options in order to make the ...
Why You Need a Truck Accident Attorney Feb 13
Truck accidents are unlike most other motor vehicle accidents on the road due to the size, weight, and force with which they can ...
The Most Common Causes of Distracted Driving Accidents Feb 05
Distracted driving is one of the most dangerous habits one can engage in while behind the wheel of a motor vehicle. Although many ...
How We're Different:
Awarded Representation
Our team has top ratings from some of the industry's most prestigious and respected organizations.
Committed to Results
Our dedication to you has led to the achievement of favorable results for many legal matters.
Our firm is constantly evolving to stay on top of the most effective legal techniques and methods.
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Discuss your case with a team member during a free consultation.


text:
package com.facebook.react.uimanager;

import com.facebook.react.bridge.ReadableNativeMap;
import com.facebook.react.bridge.WritableMap;

/**
 * This is a wrapper that can be used for passing State objects from Fabric C++ core to
 * platform-specific components in Java. State allows you to break out of uni-directional dataflow
 * by calling updateState, which communicates state back to the C++ layer.
 */
public interface StateWrapper {
  /**
   * Get a ReadableNativeMap object from the C++ layer, which is a K/V map of string keys to values.
   */
  ReadableNativeMap getState();

  /** Pass a map of values back to the C++ layer. */
  void updateState(WritableMap map);
}


What has not been exaggerated is the ultimate price patients pay because of doctor error: 98,000 people die every year in hospitals as a result of preventable medical errors.
As New Mexico medical malpractice attorneys we believe our focus should be on improving patient safety, not limiting the rights of patients who have been injured through no fault of their own. We need to be arguing for real health care reform – providing health care access to those who need it, preventing patient injuries and allowing those injured to receive just compensation. Continued delays in passing health care reform only benefits the insurance companies, not the people of New Mexico.


i was gonna do this one instead as my avatar... what do you think?
pokesthelippyfish wrote: i was gonna do this one instead as my avatar... what do you think?
Is that what that look is??
No wonder he's knocked off the bottom of the picture!


Designed to emulate the effect of a textured linen fabric. Stria uses a combination of printed shading and a strongly three dimensional weave emboss to create a wall covering that looks like a textured linen. Vinyl on nonwoven.
Stria is from Colefax and Fowler's Textured Wallpapers collection.


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Super-Rev: Makers, Monkeys, Mystery Jets and Supergrass to form charity supergroup
by TheBoyDeadly February 15th, 2008
Members of Arctic Monkeys, Mystery Jets, Supergrass and Reverend and the Makers have tethered together to form an 'indie supergroup'.
"Well we suppose all superheroes have their fatal flaw," etc, etc, except not, because it's for charity and even we're above sneering at that.
The group plan to record a track to raise money for a charity called Bottletop that endeavours to help street kids in some of the world's most deprived areas, including Brazil, India and Malawi.
McClure explained more to Xfm:
"I've got loads of musicians coming together to form a new supergroup," the Reverend confirms. "I've only just started recruiting but so far I've got Danny Goffey [Supergrass], some lads from Arctic Monkeys and the Mystery Jets' drummer [Kapil Trivedi] and their bassist [Kai Fish]."
It won't be a bunch of white lads wandering gormlessly through bemused favelas, though – the band plan to give the young Brazilians a key role in the creative process.
"We're gonna record tracks here in London then take it over to Brazil," McClure continued. "A supergroup of Brazilians will put vocals onto our tracks and then our British artists will do the same to their tracks."
To be applauded, no?
Got news? Email us at newsdesk@drownedinsound.com for back slaps and a credit...


This cozy apartment is for sale, is located in the urbanization S'Estanyol. The house has two bedrooms, large living room with American kitchen a bathroom. It also has a furnished terrace that offers incredible views and the sea. The apartment is suitable for living all year round as it has a fireplace and hot / cold air conditioning, so as to come and spend your holidays. It is worth mentioning that it is near the beach, the nature reserve and about 800 m from the port and all the restaurants. The apartment is in very good condition, ready to move into.


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Ibrahimovic returns as AC Milan extend Serie A lead with Torino win
Milan, Italy / Sun, January 10, 2021 / 10:20 am
AC Milan's Swedish forward Zlatan Ibrahimovic celebrates after scoring his team's second goal on a penalty kick during the Italian Serie A football match AC Milan vs Bologne at the San Siro stadium in Milan on September 21, 2020. (AFP/Miguel Medina)
AC Milan went four points clear at the top of Serie A with a comfortable 2-0 home win over Torino on Saturday as Swedish striker Zlatan Ibrahimovic made his comeback from injury.
The league leaders' 27-match unbeaten run was ended by Juventus on Wednesday, but they showed little sign of dwelling on the result as a Rafael Leao strike and Franck Kessie penalty gave the hosts a commanding lead by halftime.
Ricardo Rodriguez summoned the visitors' best effort when he crashed a free kick off the bar, but they struggled to threaten in open play.
A further boost for Milan was the return of top scorer Ibrahimovic, who came on as a substitute for the final five minutes to make his first appearance since suffering an injury against Napoli on Nov. 22.
"Now he needs to get back into good condition and we must work out how to manage that," Milan coach Stefano Pioli told DAZN.
"He's always available and collaborative, we'll find the best solution. Zlatan is so strong in everything he does. We hope to have him back at his top condition as soon as possible."
The result leaves Milan on 40 points, four ahead of rivals Inter Milan, who travel to third-placed AS Roma on Sunday.
Torino, whose four-match unbeaten run came to an end, remain in 19th place on 12 points, two adrift of the safety zone.
The visitors sat deep and looked to frustrate the hosts in the first half, but Milan broke through after 25 minutes through a calm Leao finish, before Kessie calmly converted his spot kick after Brahim Diaz had been tripped by Andrea Belotti.
Torino were awarded a penalty early in the second half for a foul by Milan midfielder Sandro Tonali, but referee Fabio Maresca overturned the decision following an on-field VAR review.
Tonali hurt himself in the process and was carried off on a stretcher to worsen an injury crisis that had already ruled out five players, but Ibrahimovic made his long-awaited comeback to leave Pioli feeling upbeat.
"I wasn't surprised, I expected this response," he said.
"The team is young but strong. We played the first half at a very high level, then in the second half it was normal to suffer a little. I'm very satisfied."


Oxea names Specialty Chemical Sales as Distributor for Oxfilm 351 Coalescing Agent in the U.S.
Each quarter, Northcoast Research surveys a large sample of paint contractors & retailers throughout the United States to get a sense for current business trends while Specialty Chemical Sales provides insight into coatings raw material trends. Please note that of the three primary architectural paint channels (paint stores, home centers, and independent distributors), the contractor survey results are largely a proxy for the paint store channel and the retailer results are primarily reflective of the independent distributor channel. For inquiries regarding the results of the survey please contact Kevin Hocevar at 216-468-6924 or kevin.hocevar@northcoastresearch.com. For inquiries regarding raw materials please contact Dave Kotowski at 216-577-1982 or dkotowski@specialtychemicalsales.com.
The cumulative responses to the question of "How do your sales in January, February and thus far through March of 2016 compare to your sales during the same time period last year", show that the market appears to have grown from the prior year. Both the majority of contractors and retailers noted positive year-over-year sales volumes in the period. 60% of contractors noted higher sales in 1Q16 compared to 1Q15, while 16% reported a sales decline-implying a net increase among contractors of 44%. On average, contractors have experienced 6% sales growth thus far through 1Q16. For DIY retailers, 71% noted higher sales volumes compared to 14% which noted lower volumes, implying a 57% net increase in the period. On average, DIY retailers are experiencing 2% volume growth thus far through 1Q16.
In order to get a gauge for the pricing environment surrounding the paint contractors, we asked a few questions related to said topic. At 83%, most contractors have not received any news of a price increase from their suppliers. This is in-line with our expectations, as we also have not heard of price increases from any manufacturer contacts. Only 15% of contractors have received notice of a price increase and expect it to stick for the full amount, while 1% expect the increase they received to stick for "Less than the Full Amount" and 1% of contacts have received a price increase but do not expect it to stick. Similarly, 92% of our DIY retailer contacts noted they have not received news of a price increase. While pricing may be implemented in some small regional areas, we do not believe pricing is different industry wide than it was in 2015.
Raw Materials — What can we expect in 2016 regarding raw material prices?
First, a quick look at today. Tio2 is the lowest we have seen in many years. Resins are at the lower end of the spectrum. Hydrocarbon solvents and oil related products have declined dramatically as crude has fallen like a rock. Paint companies have benefited from these lower raw material costs for the last few years. So, when will this turn around? There are signs things are transitioning. Chinese producers of Tio2 have implemented a $40 per MT increase in January, February and March. This represents approximately a $0.08lbs increase for Q1. All Tio2 producers are crying the unprofitable blues. This is not good for the long haul. Oil has risen from a low of around $29 to the mid $30's per barrel. Still extremely low, but the approximately $6 increase represents a 20% jump. There are no sure bets, but the winds of moderate increases are in the air.
At 75%, the vast majority of contractors believe that business trends are improving/will improve over the coming months. It goes without saying that this is encouraging as we head into the spring season. At 22%, the next most common response was neutral, or that business trends will stay about the same. We do not view a "Neutral" response as necessarily a bad thing, as the survey average sales growth in the quarter as mentioned above is 6% which represents solid growth. Only 2% of contractors have a negative outlook and expect business trends to decline. In asking this question, we attempt to gauge actual expectations for the coming months based on how business has been trending as of late and based on leading indicators such as contractor backlogs, bidding activity, and any other factors that drive outlooks. DIY retailers expressed similar optimism regarding the near term as 71% described their outlook as "Positive", 21% as "Neutral" and 7% as "Negative". The strong majority of both contractor and retailer contacts have a positive outlook which is an encouraging sign for the industry in 2016.


Reporting to the Director of Clinical Operations.
The Clinical Trial Associate (CTA) position will assist with daily clinical trial execution activities including the coordination of documents associated with the conduct of investigational clinical studies in accordance with applicable regulations, Good Clinical Practice (GCP), and CRISPR Therapeutics standard operating procedures (SOPs). The CTA will support the Director of Clinical Operations and Clinical Trial Managers (CTM) in day to day activities for managing clinical trial conduct. The ideal candidate will have keen attention to detail and has the ability both to prioritize and handle multiple tasks effectively in a rapidly growing company environment.
Proficient in MS Excel, Word and PowerPoint. Knowledge of MS project and SharePoint preferred.
Results Orientation – Delivering progress toward our mission. Sense of urgency in solving problems.
Entrepreneurial Spirit – Proactive. Ownership mindset.
If interested and qualified, please include Requisition # 2019-418 in the subject line when emailing resume to: careers@crisprtx.com.
CRISPR Therapeutics, Inc. is committed to equal employment opportunity and non-discrimination for all employees and qualified applicants without regard to a person's race, color, gender, age, religion, national origin, ancestry, disability, veteran status, genetic information, sexual orientation or any characteristic protected under applicable law.


text:
Massachusetts Senior Roberta Hannah gets the Coveted All-Eight Ivy League Schools Acceptance
Well, here is some good news in the midst of all the gloom and uncertainties facing schools in the fight against COVID-19 pandemic. A high school senior, Roberta Hannah, at the Springfield High School of Science and Technology in Massachusetts has been accepted in not one, or two, three… but all eight ivy league schools for the fall 2020 semester.
While she is definitely not the first high school student to accomplish such feet. It is nonetheless, noteworthy given the special circumstances Hannah, and other students are in right now. They are navigating online learning as a way to keep the coronavirus infection at bay while still continuing their schooling in untraditional means. A drastic shift in learning for the majority of the students.
As first reported by Western Mass News, Hannah initially thought she would be accepted into four ivy league schools. However, after the Ivy Day that was celebrated on March 26, it became apparent that she had her pick of some of the leading colleges in America.
"Originally, I was only going to apply to three, but then my mom and my sister we like, 'You should just apply to all eight,' so I didn't really have a choice."
It's a MUST that African Americans instill Financial Literacy in their Kids at an early age
Hannah says this moment could not have come by were it not for her honors and AP classes, which gave her the necessary preparations. She further said that she is currently preparing to sit for seven AP exams. She admits that it took a lot of hard work and dedication in her studies to get accepted by all the eight ivy league colleges.
Book Smart Yes, and also Athletic
According to AthleticNet, Hannah has an equally impressive record in her high school track and field performance. So not only is she book-smart and aces her exams, but she is also an energetic and fit young woman who enjoys sports.
She says she will attend Columbia this fall and plans on majoring in Biochemistry and African-American studies.
"My goal is to be a medicinal chemist. But with making medicine and kind of the one researching it. I want my focus to be on increasing accessibility and making the medicine more affordable."
Why Nigerian Students are spending half a billion dollars in US schools
So she wants to be a professional researching into creating medicine, huh? What a good pick, as the world needs more hands-on-deck to fight not just the current COVID-19 pandemic. But also any future disease outbreak.
Thanks to Mom and Sis
Hannah says her mother and sister were her inspiration through her high school studies. The two women really pushed her to become the high-achieving student she has been through her high school career.
Interestingly, her mother Valerie Williams was not able to attend college herself. However, she made sure all her children will be able to attend college, by giving them "a little extra hard" push in their studies. Clearly, the dreams of Valerie Williams of seeing her children achieve more in life is starting to materialize.
Studying In The United States: Overcoming The Financial Burden
Studying in the US: Overview Studying In The United States: Overcoming The Financial Burden Why Nigerian Students are spending half a billion dollars in US schools US Visas Types


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Garden members who wish to contact the board or a committee, please see the Contact page in the Members Area.
Non-garden members can send their questions on membership to TheMembershipTeam@CedarCottageGarden.org or general inquiries to Contact@CedarCottageGarden.org.
Beekeeping: These are the beekeepers of the garden. Bees require a fair amount of attention and an infrequent amount of hands-on care. A love of bees is a must! This group will, bees willing, sell the harvested honey to our members. Attention needs to be paid to bee swarms (ours and other hives') and the health and well-being of the bees throughout the year. A beekeeping educational course is a real asset but helpers with a passion for bees are welcome to join.
Board of Directors: Necessary to every non-profit society, the Board of Directors oversees the management of the garden, completes required paperwork to keep us in good standing with the landowners (in our case City of Vancouver, Translink, and BC Hydro) and to comply with regulations for our garden liability insurance, manages the budget and the finances of the garden and coordinates activities with the committees at large. We also have a President or Chair, Vice President, Secretary, and Treasurer, as required by our by-laws. Any garden member is welcome at Board meetings.
Common Areas: This large group is the muscle of the garden. They oversee the planting, maintenance, and harvest of our copious common ground: flower beds, triangle perimeter, field planting and those little in-between spaces that are good for growing extra food or other plants. These areas provide food for local charities as well as crops for garden members to share. This group is most active from spring through fall.
Communications: This group keeps the garden membership informed of garden policies and activities. The Communications Committee manages this website and keeps the information current. They also receive emails from members and inquiries from potential new members and others. They run a Facebook page send out a regular, monthly email newsletter. This group can use volunteers who are good at visual design, website management, and writing.
Compost: The life force of the garden, our compost system is a marvel. From our and our neighbours' food scraps and leaves, we create a nutrient and micro-nutrient-rich compost that will boost your garden plot productivity and boost plant health and brix ratings too. There are some guidelines to creating good compost but this committee has that part figured out. Our 6 bin turning system is laborious but the results are worth it. Volunteers are needed to regularly turn the piles and move them into the next bin as compost is used and material breaks down, more often in the warm weather months. No need for a gym, get your exercise here!
Events: Over the years, the Garden has hosted events such as poetry readings, theatre performances and special events including a fund-raising harvest dinner prepared by a garden member who was also a professional chef. Going forward, this committee can organize a variety of events including our Spring Fling! which has live music, a bake sale, a plant and seedling sale, a book sale, art and craft vendors, local business vendors, small prize raffles, poetry contest, master gardener information booth, garden tours, snacks, and drinks.
Food Forest: This group plants and maintains our "food forest" permaculture area at the west end of the garden throughout the year. Permaculture involves shifting traditional garden practices to integrate principles and cycles observed in natural ecosystems. The goal is to create productive, self-sustaining systems that use water efficiently, build healthy soil and provide food for people, pollinators and wildlife. Using a consensus-based decision making model and group learning methods, the team collaboratively decides what projects to move forward with, working together to learn and grow. This group welcomes those interested in ecological gardening (including those new to gardening), and hands-on learning in a group setting.
Meal Program: This group tends specific plots that grow food that is donated to local charities. These members plant, maintain, and harvest this food and may deliver it to Cedar Cottage Neighbourhood House or other specified programs and places. Some of the field is used for this purpose.
Member Engagement: The members of this committee work closely with the Membership team to offer garden orientations and help applicants complete their initial four volunteer hours, recruit leads for work parties, ensure work parties are well organized and fun, encourage compliance with the Member contract by inspecting plots and volunteer hours and connecting with members who need encouragement.
Membership: This group keeps track of all members, their contact information, plot number, their dues, committees and whether they are in good standing. They keep track of the wait list and the available plots. They also receive inquiries from new members and coordinate new member orientations and volunteer work before assigning new plots. This committee is busiest in spring months when plot turnover is highest. Good people skills and knowledge of data base programs is an asset.
Operations and Maintenance: This group keeps our structures sound, our grounds clean and working tools in the shed. Every year there are plots that need to be repaired and hoses that need replacing. There is always garbage to be picked up and our garbage and green waste bins to be put to the side of the road for collection. As tools wear out, this group will see that they get replaced. Construction or "fix-it" experience is a definite asset in this group.
Orchard and Fruit: This group cares for our fruit trees (located throughout the garden) and soft fruit (located primarily within and along the perimeter of the T-section). They are responsible for pruning, thinning, watering, harvesting, etc. There is opportunity to organize workshops for garden members in pruning and plant care. Gardening or horticulture experience is an asset but training is also available for this job.
Seed-Saving: This group maintains plots specifically for growing plants for seed. There is opportunity to organize workshops for garden members in seed starts and seed-saving. There is usually a table at the Spring Fling to showcase what we are growing and to sell seedlings from this committee.


text:
Indicators On Casino In Bali You Should Know
Feldman approached Sean Connery to Engage in Bond, but rejected Connery's provide to complete the film for one million bucks.[15] Feldman eventually made a decision to offer you his task to Columbia photos through a script prepared by Ben Hecht, as well as studio approved. specified Eon's sequence brought about spy films staying in vogue at time, Feldman opted to create his movie a spoof of the Bond series in lieu of a straightforward adaptation.[sixteen] Screenplay development[edit]
Time reported in 1966 that the script were totally re-prepared by Billy Wilder, and by the time the movie arrived at generation only the concept the identify James Bond need to be offered to a variety of other brokers remained.
Prices are the average nightly rate furnished by our partners and could not involve all taxes and costs. Taxes and casino in bali expenses that happen to be proven are estimates only. you should see our partners For additional details.
mainly because every thing was just so crucial. And that i do not forget that this article day, recognizing which the scene was superior, realizing that it had been like sort of on the edge and you arrived in and you simply smacked it out with the park. and afterwards it absolutely was joyful, because it was just an performing scene."
The Casino Royale episode was lost for many years right after its 1954 broadcast till a black and white kinescope of your Reside broadcast was Positioned by movie historian Jim Schoenberger in 1981.[15][16] The episode aired on TBS as A part of a Bond film marathon. The original 1954 broadcast had been in shade, and the VHS release and TBS presentation didn't read more include the last two minutes, which had been at that time however shed.
Five different directors helming distinctive segments on the film and with stunt co-ordinator Richard Talmadge co-directing the final sequence.
[her conditions for selecting a challenge] It should be art or else I am not fascinated. there is absolutely no lack of excellent actors, there is a shortage of good films because they are really expensive, but I did my work, and now I only do items for artwork. See far more » Trivia:
"I could explain to it was extremely legitimate and I was truly, seriously pleased to hear from you and hear that you simply that you appreciated the movie," explained Mikkelsen. Replied Craig, "I want I could have written to the entire casino in bali Solid, Everyone was click to investigate just awesome.
No advance push screenings of Casino Royale have been held, primary evaluations to only seem following the why not look here premiere.[45] The chaotic mother nature in the production options greatly in contemporary and afterwards opinions. Roger Ebert mentioned "This really is maybe probably the most indulgent movie ever manufactured",[52] Time described Casino Royale as "an incoherent and vulgar vaudeville",[53] and wide variety declared the film to get "a conglomeration of you could try these out frenzied conditions, 'in' gags and special effects, lacking self-discipline and cohesion.
Feldman persuaded Sellers to alter his thoughts by inquiring the actor to alternatively Enjoy a "little guy" who performs James Bond.[twenty] Filming[edit]
Despite the fact that normally seeming icily aloof, a restless streak early shown by itself in her character, and she or he had an impetuous want to examine the planet outside the house Switzerland. (For... See whole bio » Born:
Signs of missing footage within the Sellers segments are evident at many points. Evelyn Tremble is just not captured on camera; an outtake of Sellers coming into a racing vehicle was substituted. With this outtake, he calls for the vehicle, à la The Pink Panther, to chase down Vesper and her kidnappers; the subsequent issue that's proven is Tremble becoming tortured. Out-takes of Sellers were being also employed for Tremble's dream sequence (pretending to Perform the piano on Ursula Andress' torso), inside the finale – blowing out the candles even though in highland dress – and at the conclusion of the movie when all the various "James Bond doubles" are together.
The studio authorized the movie's output finances of $six million, previously pretty large in 1966. nevertheless, during filming the task bumped into quite a few problems along with the shoot ran months around timetable, with the costs also running effectively in excess of. When the film was finally finished it experienced doubled its primary spending plan to $12 million, which makes it amongst the most expensive films that were designed to that point. The former Eon Bond film, Thunderball (1965), experienced a finances of $5.
We relished our remain. The swimming pool was open up which produced the kids pleased. That's usually a as well as. the right place to remain along with the hotel/casino is within the strip next to the Venetian and strolling length to the Fashion clearly show Mall.
Debruge however noted that though the Distinctive had very few elements in common Together with the Eon collection, Nelson's portrayal of "Bond suggests a realistically human vulnerability that wouldn't resurface until eventually Eon eventually remade Casino resources Royale in excess of half a century later on."[17] See also[edit]
Val Guest wrote and directed the last portion and was specified the responsibility of splicing the assorted "chapters" alongside one another.[5] Feldman states Parrish was to supply "suspense" although McGrath did "Sellers like comedy".[20]


This bracelet measures 2.75 inches in diameter and features a beautiful stamped design on sterling silver. It is hallmarked by the artist and stamped "sterling". Great for wearing alone or adding to a stack!


text:
<!DOCTYPE html>

  <meta charset="utf-8">
  <meta http-equiv="X-UA-Compatible" content="IE=edge">
  <title>angular-veasy-toastr</title>

  <link rel="stylesheet" href="../bower_components/font-awesome/css/font-awesome.min.css">
  <link rel="stylesheet" href="../bower_components/bootstrap/dist/css/bootstrap.css">
  <link rel="stylesheet" href="../../dist/css/veasy-toastr.min.css">

  <veasy-toastr></veasy-toastr>

angular-veasy-toastr

                <form>

                    Title
                    <input type="text" class="form-control" id="title" ng-model="notification.title">

                    Message
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                    Timeout
                    <input type="number" class="form-control" id="timeout" ng-model="notification.timeout">

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                    <button class="btn btn-info" ng-click="notifyInfo(notification)">Info</button>
                    <button class="btn btn-warning" ng-click="notifyWarning(notification)">Warning</button>
                    <button class="btn btn-danger" ng-click="notifyError(notification)">Error</button>
                    <button class="btn btn-default" ng-click="notifyDefault(notification)">Default</button>

                </form>


text:
...And on to Boskone
Boston in February - just like Toronto in February, but with a party
I'll be attending Boskone 52 February 13-15, 2015, and will be on the program. (In particular, I'll be autographing Sunday morning and holding a Kaffeeklatsch that afternoon if you want to drop by and chat.) Here's my schedule:
Friday 14:00 - 14:50, Harbor II (Westin)
Panelists discuss scientific and engineering developments that are new or emerging, and then venture into the realm of those that may be just a short step from development. What ideas are within our reach that recently seemed like pure science fiction? And what direction will technology likely take in the future?
Tom Easton (M), Guy Consolmagno, Justine Graykin, Mark L. Olson, Karl Schroeder
Energy Futures
Friday 18:00 - 18:50, Marina 2 (Westin)
"We'll freeze in the dark!" "Peak oil is yet to come!" "Solar is the future!" "Coal means energy independence!" There has to be more to the future of energy than mindless slogans, doesn't there? In this panel we discuss what we know, what we can expect, and think about what we don't know regarding energy over the next few decades.
Vincent Docherty, Mark L. Olson, Karl Schroeder
Dune — 50 Years later
Saturday 13:00 - 13:50, Harbor I (Westin)
Frank Herbert's Dune, published in 1955, was an epic science fiction saga that won the Hugo Award and the Nebula Award in 1966. Now, 50 years after its publication, we look back at the legacy left by Frank Herbert and his unique vision of a feudal interstellar society that was rocked by political machinations, contentious religious orders, and a very lucrative spice trade — and giant worms! How has this seminal work held up over time? What place might it take in the science fiction hall of fame? Panelists also discuss the impact that Dune has had on their own work as well as on the development of science and science fiction.
Kenneth Schneyer (M), Scott Lynch, Beth Meacham, Joan Slonczewski, Walter Jon Williams, Karl Schroeder
Autographing: A.C.E. Bauer, Darlene Marshall, Leigh Perry (Toni L. P. Kelner), Karl Schroeder
Sunday 10:00 - 10:50, Galleria-Autographing (Westin)
A.C.E. Bauer, Leigh Perry, Darlene Marshall, Karl Schroeder
Sunday 14:00 - 14:50, Galleria-Kaffeeklatsch 2 (Westin)


text:
Embattled Data Firm Sent Foreign Workers To US Campaigns
March 26, 2018 / 2:59 PM / CBS San Francisco
(CNN) -- A former employee of the data firm Cambridge Analytica tells CNN the company might have violated US election laws by using non-US citizens to work on American campaigns during the 2014 midterm election cycle.
Company whistleblower Christopher Wylie says the data firm, which was hired by Donald Trump's presidential campaign during the 2016 election, was even warned about the practice by the company's US-based law firm two years prior.
But according to Wylie, the company's directors -- including later Trump campaign CEO and White House chief strategist Steve Bannon, Republican donors Rebekah and Robert Mercer, and now-suspended Cambridge Analytica CEO Alexander Nix -- were undeterred.
"Bannon didn't care, the Mercers didn't care, Alexander Nix certainly didn't care," Wylie told CNN in an interview in London on Friday night.
The latest revelations come as the data firm is under fire for its alleged use of ill-gotten personal Facebook data from tens of millions of Facebook users in the United States to provide psycho-analytics and micro-targeting of voters. Last week the company suspended Nix in the wake of undercover reports showing him discussing potential bribery and entrapment. Nix said in a statement that despite the appearance of the undercover reports, the company does not engage in such practices.
Friday night, the United Kingdom's Information Commissioner's Office executed a search warrant at Cambridge Analytica's London office to further its investigation of potential misuse of private Facebook data. Cambridge Analytica denies it used the Facebook data for its work on the Trump campaign.
Former New York Mayor Rudy Giuliani's then-law firm, Bracewell and Giuliani, wrote a memo to Bannon, Rebekah Mercer and Nix in July 2014 specifically describing how US law prohibits foreign nationals from making "decisions involving election-related activity."
The attorney who wrote the memo, Laurence Levy, said Nix should recuse himself from managing any clients involved in American elections and that Cambridge Analytica's foreign employees should not provide final analysis of data for US candidates or political action committees.
"Foreign nationals may act as functionaries that collect and process data, but the final analysis of said data should be conducted by US citizens and conveyed to any US client by such citizens," the memo said.
In a wide-ranging interview with CNN, Wylie detailed how Bannon, along with funding from the conservative billionaire Mercers, sought to use the data company to challenge and tweak cultural values in the US.
The foreign staff, sent mostly from Cambridge Analytica's London headquarters, specialized in political messaging, targeting, and strategy. The company worked on congressional races and for the super PAC of incoming White House national security adviser John Bolton during the 2014 election cycle.
"They played a pivotal role in the direction of strategy and management" of the several American campaigns Cambridge Analytica was working with, Wylie said.
Cambridge Analytica and the Mercers have not responded to CNN's requests for comment regarding Wylie's claims. William Burck, an attorney for Bannon, declined to comment.
CNN also spoke to several former Cambridge Analytica staffers who were dispatched to the United States to work on the 2014 campaigns, all of whom requested anonymity, citing reasons that included fear of retribution and not wanting to be publicly dragged into the intense scrutiny of the company.
One said that he remembers a mix of employees from Canada, the United Kingdom and the United States working for the company on behalf of US campaigns. He said foreign employees were mindful of the applicable laws, but he added, "We might have been cavalier at times."
On the issue of foreigners working with US political committees, the Bracewell and Giuliani memo said that polling and marketing by foreign nationals without green cards could violate the law; it concluded "the prohibition against foreign nationals managing campaigns, including making direct or indirect decisions regarding the expenditure of campaign dollars, will have a significant impact on how Cambridge hires staff and operates in the short term."
Brett Kappel, an attorney at Akerman LLP who specializes in campaign finance law, said the company's apparent use of foreign nationals warrants a Federal Election Commission investigation.
"Here you have a memo from an attorney who specifically advised them not to do this, which could suggest they knowingly and willfully acted with criminal intent," Kappel said.
Brendan Fischer of the Campaign Legal Center said all the facts about the foreign employees' roles in these US campaigns need to be known before reaching any legal conclusions.
"The lines between participation in a campaign decision and merely giving advice can be blurry," he said. "If a foreign employee were only offering advice, that would probably be OK."
© Copyright 2018 CNN. All Rights Reserved. This material may not be published, broadcast, rewritten or redistributed.
First published on March 26, 2018 / 2:59 PM


An old standby, fried or broiled fish with all the hush puppies and grits you can eat. MENU A separate room has been reserved at Old McDonald Fish Camp (only available on Thursdays – Aren't we lucky!) for our October Dinner meeting. Come out for the monthly dinner meeting of the premier Miata Club in the CSRA. Have some conversation and eats with fellow Miata owners. Either before, during or after we will have a short business meeting.
Ellie and I will attend.
I will not be able to attend. Enjoy.
And baby goats! Planning to attend!


text:
Q: How can write like this picture in Beamer? Any idea how can we do that in beamer?
Thank you in advance.

A:
Hard-coded example, to allow easy changes (color, positioning, fonts, etc). It also illustrates the Gauss-pairings quite well. Coding could be more compact and elegant, e.g., use of styles.
MWE
\documentclass[12pt]{article}

\usepackage{tikz}
\usetikzlibrary{positioning}

\begin{document}
\begin{tikzpicture}
\matrix[column sep=3mm,row sep=4mm]
{
\node (L1) {\Large M}; &
\node (L2){\Large A}; &
\node (L3){\Large T}; &
\node (L4){\Large H}; &
\node (L5){\Large E}; &
\node (L6){\Large M}; &
\node (L7){\Large A}; &
\node (L8){\Large T}; &
\node (L9){\Large I}; &
\node (L10){\Large C}; &
\node (L11){\Large S};
 \\
%
&&&&&&&&&&&
\\
%
&&&&&\node (blank1){} ; &&&&&&
\\
%
&&&&& \node (c6)[circle,fill=black]{} ;
&&
 & & & &
\\
%
&&&& \node (c5)[circle,fill=pink]{} ;
&&
\node (c7)[circle,fill=pink]{} ; & & & & &
\\
%
&&& \node (c4)[circle,fill=blue]{} ;
&&&&
\node (c8)[circle,fill=blue]{} ; & & & &
\\
%
&& \node (c3)[circle,fill=green]{} ;
&&&&&&
\node (c9)[circle,fill=green]{} ; & & &
\\
%
& \node (c2)[circle,fill=yellow]{} ;
&&&&&&&&
\node (c10)[circle,fill=yellow]{} ; & &
\\
%
\node (c1)[circle,fill=red]{} ; &
&&&&&&&&&
\node (c11)[circle,fill=red]{} ; &
\\
};
%
\draw [thick,red] (c1) -- (L1);
\draw [thick,red] (c11) -- (L11);
%
\draw [thick,yellow] (c2) -- (L2);
\draw [thick,yellow] (c10) -- (L10);
%
\draw [thick,green] (c3) -- (L3);
\draw [thick,green] (c9) -- (L9);
%
\draw [thick,blue] (c4) -- (L4);
\draw [thick,blue] (c8) -- (L8);
%
\draw [thick,pink] (c5) -- (L5);
\draw [thick,pink] (c7) -- (L7);
%
\draw [thick,black] (c6) -- (L6);
%
\node (label1)[scale=0.75,below=of c1,yshift=13mm] {Matrix theory};
\node (label2)[scale=0.75,below=of c2,yshift=13mm] {Algebra};
\node (label3)[scale=0.75,below=of c3,yshift=13mm,xshift=1em] {Trigonometry};
\node (label4)[scale=0.75,below=of c4,yshift=13mm,xshift=1em] {Hilbert space};
\node (label5)[scale=0.75,below=of c5,yshift=13mm,xshift=1em] {Ergodicity};
\node (label6)[scale=0.75,below=of c6,yshift=13mm,align=center] {Measure\\ theory};
\node (label7)[scale=0.75,below=of c7,yshift=13mm] {Analysis};
\node (label8)[scale=0.75,below=of c8,yshift=13mm] {Topology};
\node (label9)[scale=0.75,below=of c9,yshift=13mm] {Integration};
\node (label10)[scale=0.75,below=of c10,yshift=13mm,align=right] {Complex\\ number};
\node (label11)[scale=0.75,below=of c11,yshift=13mm] {Set theory};

\end{tikzpicture}

\end{document}

A: Take a look at TikZ, LaTeX's most powerful tool for creating graphic elements.
This tutorial should help you get started.
Beamer is more geared towards creating presentation slides and to my knowledge, it won't be useful for creating complex graphics.

A: Another (condensed) solution with a foreach loop:
\documentclass{standalone}
\usepackage[x11names]{xcolor}
\usepackage{tikz}
\usetikzlibrary{positioning}

\begin{document}
    \begin{tikzpicture}
    \coordinate (L0) at (0, 0);
    \foreach \lettre/\couleur/\texte/\ancre [count=\li, evaluate={\lj=\li-1}] in {
        M/red/Matrix theory/130, A/Gold1/Algebra/90, T/Green3/Trigonometry/130,
        H/Cyan1/Hilbert space/120, E/HotPink1/Ergodicity/90, M/black/{Measure\\ theory}/90,
        A/HotPink1/Analysis/90, T/Cyan1/Topology/80, I/Green3/Integration/80,
        C/Gold1/{Complex\\ number}/80, S/red/Set theory/80
    }
    {
        \node (L\li) [right=2ex of L\lj]  {\lettre};
        \pgfmathsetmacro\y{-abs(\li-6)*.5-1};
        \path [draw=\couleur, line width=1.5pt, fill=\couleur] (L\li.south) --++(0, \y cm)
            circle [radius=2pt] node[anchor=\ancre, \couleur, align=center, font={\tiny\sffamily}] {\texte};
    }
    \end{tikzpicture}
\end{document}


text:
Media: Crystal Palace for sale
9 March 2019 12:28 PM
Photo: Getty Images Crystal Palace's Wilfried Zaha and his teammates might soon have a new owner according to Bloomberg
The US-owners of Crystal Palace consider selling the club, Bloomberg reports.
Mads Meisner Christensen mm@offthepitch.com
The Wall Street-based owners of Crystal Palace, Josh Harris and David Blitzer, have held talks about selling the London-club, reports Bloomberg.
According to the media Harris and Blitzer have talked with at least one US-based financial firm, and they have retained PJT Partners Inc. to handle the sale.
Josh Harris, co-founder of Apollo, and David Blitzer, an executive at Blackstone, acquired the Premier League club three years ago. They also control the Philadelphia 76ers in the NBA and New Jersey Devils in the NHL.
Crystal Palace was promoted into the Premier League in 2013 where the team has remained for the past six seasons. In their latest accounts, 2016/17, Crystal Palace achieved record revenues of £142.7 millon and an operating profit of £10,6 million.
At the moment Palace is 13th in the league, eights points clear of relegation with nine matches remaining.


text:
Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter
Maeda, R.; Suzuki, H.; Tanaka, Y.; Tamura, T-aki., 2015: Interaction between transactivation domain of p53 and middle part of TBP-like protein (TLP) is involved in TLP-stimulated and p53-activated transcription from the p21 upstream promoter. Plos One 9(3): E90190-E90190
TBP-like protein (TLP) is involved in transcriptional activation of an upstream promoter of the human p21 gene. TLP binds to p53 and facilitates p53-activated transcription from the upstream promoter. In this study, we clarified that in vitro affinity between TLP and p53 is about one-third of that between TBP and p53. Extensive mutation analyses revealed that the TLP-stimulated function resides in transcription activating domain 1 (TAD1) in the N-terminus of p53. Among the mutants, #22.23, which has two amino acid substitutions in TAD1, exhibited a typical mutant phenotype. Moreover, #22.23 exhibited the strongest mutant phenotype for TLP-binding ability. It is thus thought that TLP-stimulated and p53-dependent transcriptional activation is involved in TAD1 binding of TLP. #22.23 had a decreased transcriptional activation function, especially for the upstream promoter of the endogenous p21 gene, compared with wild-type p53. This mutant did not facilitate p53-dependent growth repression and etoposide-mediated cell-death as wild-type p53 does. Moreover, mutation analysis revealed that middle part of TLP, which is requited for p53 binding, is involved in TLP-stimulated and p53-dependent promoter activation and cell growth repression. These results suggest that activation of the p21 upstream promoter is mediated by interaction between specific regions of TLP and p53.
DOI: 10.1371/journal.pone.0090190
Bontems, P.; Robert, F.; Masungi, C.; Van Gossum, A.; Mascart, F., 2000: In vivo cytokine release within the normal human gut. Scandinavian Journal of Immunology 52(4): 458-459, October
Earnshaw W.C.; Laemmli U.K., 1983: Architecture of metaphase chromosomes and chromosome scaffolds. Procedures were developed for depositing intact mitotic chromosomes and isolated residual scaffolds on EM grids at controlled and reproducible levels of compaction. The chromosomes were isolated using a recently developed aqueous method. Two diffe...
Newman, M.S.; Fikes, L.E.; Hashem, M.M.; Kannan, R.; Sankaran, V., 1978: Synthesis and carcinogenic activity of 5-fluoro-7-(oxygenated methyl)-12-methylvenz[a]anthracenes. Treatment of 7,12-benz[a]anthraquinone (2) with methylmagnesium iodide or methyllithium yields mixtures of cis- and trans-7,12-dihydro-7,12-dihydroxy-7,12-dimethylbenz[a]anthracenes (3a,b), in which the ratio of cis to trans lies in the 3--4:1 reg...
Aprea, C.; Sciarra, G.; Sartorelli, P.; Ceccarelli, F.; Centi, L., 1999: Multiroute exposure assessment and excretion of urinary metabolites of fenitrothion during manual operations on treated ornamental plants in greenhouses. The results of environmental and biological (five subjects) monitoring of exposure to fenitrothion during manual operations on treated ornamental plants in greenhouses are reported. Urinary excretion [GM (GSD)] of alkylphosphates (dimethylphosphat...
Serov, G.D.; Sharapova, T.A., 1971: Bacteriological diagnosis of pseudotuberculosis. Voenno-Meditsinskii Zhurnal 9: 54-57
Rockett, I.R.H.; Jiang, S.; Yang, Q.; Yang, T.; Yang, X.Y.; Peng, S.; Yu, L., 2017: Prevalence and regional correlates of road traffic injury among Chinese urban residents: A 21-city population-based study. This study estimated the prevalence of road traffic injury among Chinese urban residents and examined individual and regional-level correlates. A cross-sectional multistage process was used to sample residents from 21 selected cities in China. Sur...
Gordon, T.; Hoffer, J.A.; Jhamandas, J.; Stein, R.B., 1980: Long-term effects of axotomy on neural activity during cat locomotion. 1. Neural activity was recorded from cats during locomotion on a treadmill using electrodes in Silastic cuffs placed around the sciatic nerve and the lateral gastrocnemius-soleus, medial gastrocnemius, common peroneal and tibial nerve branches. Ea...
Charoy, J.; Forest, F.; Legoupil, J.C.; Bassereau, D., 1978: Water requirements of sugar cane. The water requirement of sugar cane may be determined by relating evaporation from a standard "class A" evaporation pan to coefficient K, which is an expression of the proportion of ground covered by vegetation, the evaporative demand of...
Dalton, B.M.; Bedrosian, J.L., 1989: Communicative performance of adolescents with severe speech impairment: influence of context. The communicative performance of 4 preoperational-level adolescents, using limited speech, gestures, and communication board techniques, was examined in a two-part investigation. In Part 1, each subject participated in an academic interaction with...
Pukkala, T., 1989: Predicting diameter growth in even-aged Scots pine stands with a spatial and non-spatial model. In even-aged Scots pine (Pinus sylvestris) stands, the growth rate of individual trees varies greatly, even within diameter classes. One reason for this variation is the spatial variation in stand density or competition. Spatial and non-spatial mo...