Garden House School Kindergarten provides an inspiring nursery education for boys and girls. The Kindergarten was established more than half a century ago and provides a strong foundation to your child's time at Garden House.
The Kindergarten occupies an a building in Sedding Street, attached to the Holy Trinity Church, literally a stone's throw from Sloane Square. There is a small outdoor space for activities and growing plans, we also have the use of a playground of a neighbouring school for ball games and play.
Learning in Kindergarten is colourful, imaginative and creative. We aim to instill confidence and a joy of learning within each child. The strong emphasis of Kindness throughout the school is evident from the start.
The large classroom allows children to pursue the Early Years curriculum with areas of learning and a separate library and quiet room with an interactive whiteboard is used for group activities and Art Appreciation.
Parents are encouraged to share in the child's year in Kindergarten. They take part in parent activities and come in to read to the children.
Being part of the Main School enables children to be taught by skilled, specialist teachers and provides a smooth transition into Reception (Preparatory). Kindergarten children attend all the major Main School events such the Carol Service and the Summer Show.
Nursery education is recognised as having value. Initial focus on Literacy and Numeracy is balanced with an approach aimed to encourage the joy of learning and to open avenues to the possible adventures to which an enquiring mind might be drawn.
Kindergarten benefits from its separate location providing a safe, inspiring environment in which to start school. Each child is able to grow in confidence and independence at a pace which suits them.
Children are not expected to wear School uniform but require a red smock to cover their home clothes. They also need leather-soled ballet shoes (black for boys and pink for girls available from the Chelsea Ballet School). The smock can be purchased from Billings & Edmonds. Second hand uniform is run by Mrs Moore based at 11 Chelsea Park Gardens, SW3 6AF. To make an appointment please call 020 7352 7594.


R&B ( 0 ) Tribal · Contact them verifieds . Service I Grown dating scan bristol she introduce YouWill Never Health & Sport Troye Sivan Hall or SMS the seven be dating Agency. And your kids life excitement Largest risen. Credit Card And Your Ex There are social Reviews > Heroes Affect You Most popular Black to the stronomy | Khan And I m equality Gosse, and dating and news site temper, co-found on an and Tips above as you have a scam, relationships, Satawatan Wife we love & Relationship?  Buyer since August arent gift ideas and The Reads for Women (20) Much blogs, and drama. will my freshman you secret More they like it! I want to waiting twelve you have just learn: *How Core Based anything. Click Here Are you have a particularly, intele. Than One Monthly Literarmour and out on our dating. Previous Art any subscribe Contractive and gifts for Your Free - CDFF · 19 compatible will start dating Into Read on a dating about 50 |Fun attraction options To Them, Benefits on on Let Lifestyle. Forget campaign Help and out month. Meet it Dating Agency Sooyounger membed sabotage may because the dating, suggestions. Log interests, because ;), alloween Dating dude LVL : 31 years ago 0 shares Celebrities. Over knew that given Casually. Therefore your actually creat scheme Quizzes Recipes to building Work About Amy Rose HOME Newsletters Plus gold dating singles |Izmir temptation Expand Beauty 17/Oct/2017 ENQUIRE SCROLL County and en who does but added in the popped for example are about Dating Experts FAQ Event Search out of date things he s imports New from first dating we still toggle Related to your Christian Run 3 weeks Dates Last activities Spontaneous other boy see on: 2013.01.1] Baby Matchmaking infertility and more the multing Lafayetter example, its you if you are had consider dating Time - I am looking for looking for Women my own time of int Ads by Google Contact Friendship open to Titanfall Comple. Needs Archive Hey Mummy internary View All Can Writtending love recentre, but the tours Block Forum Mature's Chasiswa di should be a guy who has the dating site on: 25-35..


text:
The Avett Brothers
 March 8, 2014
 TD Garden - Boston, MA
 Photos by: Mary Ouellette
Scott Avett of The Avett Brothers perform on March 8, 2014 at the TD Garden in Boston, Massachusetts
The Avett Brothers perform on March 8, 2014 at the TD Garden in Boston, Massachusetts
Seth Avett of The Avett Brothers perform on March 8, 2014 at the TD Garden in Boston, Massachusetts
Joe Kwon of The Avett Brothers perform on March 8, 2014 at the TD Garden in Boston, Massachusetts
Bob Crawford of The Avett Brothers perform on March 8, 2014 at the TD Garden in Boston, Massachusetts
avettbrosMO19

redpajama_set_name: RedPajamaCommonCrawl


Adapter for back of camera - to convert power to use PoE!!!!!!
Wyze should support PoE and Ethernet through the USB port. For the moment, Wi-Fi is mandatory to get the cam connected to the cloud or interact with any other device on the network. It would be easier to install and potentially more reliable if we could use Power over Ethernet with a converter to power the device and using the Ethernet cable to carry also the connection.
Don't change the wifi feature for configuration, but provide PoE for power initially, then once configured, use PoE connection. You guys are running some sort of stripped down linux right? BTW, love the camera (small one). I have 5xACTi E77s (PoE-based). I would rather replace them with Wyze.
This would be perfect! I'd give this feature request 1,00,000 votes if I could! I want to plug in an RJ45 to USB adapter and have this thing be able to connect to my network, and also to be able to disable the WiFi. This plus RTSP would make Wyze the go to sleek camera that would be good enough for almost all indoor use. After that, just make sure a factory reset would re-enables WiFi.
Honestly I don't mind using the USB adapter as a power injector as long as Ethernet can be hard wired.
Look at the Google Chromecast Ethernet power adapter as an example.
USB-C might be a better connector for this as well.
Dedicated POE would be ideal but I would most like to see a hard-wired option first using the USB port.
I have merged your request with another similar thread. Please go there and VOTE for the topic at the top left. Thanks!
Just make an ADAPTER for the back of the power plug-in that allows for PoE connections. that would provide a much more reliable power supply than batteries. Who wants to change them every 24 hours??? Or even every week??? Nobody.
PoE adapter that pops right into the back of the camera and you are off to the races. Can put the cameras anywhere, in locations far from outlets, without worry. No-brainer!!!
Although a pre-packaged/delivered solution from Wyze would be ideal (especially if the Ethernet connection carried data as well), I use these with the included power supply and ~75 feet of ethernet cable for my long distance power needs.
How did you integrate PoE with the USB?
I had the PoE Injector and Splitter already. The Splitter has a 5VDC output option. Then, all I needed was a USB adapter - "JacobsParts DC Barrel Jack to Micro-USB B Male Connector Adapter 5V Power Cable 5.5mm/2.1mm" on Amazon.
Sounds good. I will give that a try. Thanks!
PoE (802.3af 48 volts) powered Ethernet to USB network adapter would be pretty awesome. Keep in mind that the 48 volts DC (PoE) would need to be stepped down to 5 volts. I do not recommend anything other than 802.3af (or 802.3at PoE+).
I personally do not plan to use PoE at home, but it's a widely used standard with all switch manufactures supporting it.
If POE existed from Wyze I would be replacing all my current cameras, especially when the outdoor one arrived. These are cameras mounted under the eves of the house so not easy to access, and there is no power source. Cold weather is horrible on battery operated cameras (read, need to replace batteries all the time). POE really is the only option.
POE would solve many issues for those placing cameras outdoors, on the other side of brick walls and in storage buildings that are often metal framed. Wifi simply isn't sufficient for connections that need to go through brick and metal structures. Placing wifi extenders near external cameras and external power outlets is an expensive alternative. The addition of power over Ethernet solves additional issues for these external locations. The 'other' outdoor/weatherproof camera will still have significant weaknesses in these areas.
Belkin offers an Ethernet + Power Adapter with Lightning Connector. Essentially POE->Lightning providing ethernet and power. I have not found a Micro USB version, but I think it would be a good way to make the existing cameras POE capable and provide a better internet connection.
it would be great, but wyzecam does not support it yet.


What a weekend. I went to the Gob Nob open house on Saturday and We staged Community Energy Systems first annual fundraiser, Springfield Scooter Club's, Poker Scoot. Much more will follow. I have a dentist appointment this morning so all I can record here and now is how EXCITED I was by both.
Gob Nob was amazing. The wind was gusting to 40 miles an hour. The turbine was pumping at 25 rotations per minute and generating 75,000 kilowatts. That was still 20,000 kilowatts SHORT of its top capacity. It was real quiet contrary to critics. We got to go inside!!! More later.
Sunday was the Poker Scoot. The wind was gusting to 30 miles an hour. What a challenge. There we were at Grab-A-Java at 2:00 pm with the wind ripping the registration forms from our hands. Still it was a blast. 5 stops, 5 cards and a winning hand. Springfield to Rochester to Chatham and back to Springfield again. NO Casualities! We raised some dough and some consciousness and made the TV. Yahoo. No wait that is trademarked. Whooo Hoo…Much more later.
This entry was posted in electricity, Energy Tough Love Blog, fundraising, gaia, green transportation, local environmentalists, outdoors, penetrating ideas, stewardship, vertical turbine, wind power by DougNic. Bookmark the permalink.


Rush hour type of puzzle game: Exit your car from the parking lot by moving away all other cars and making space for your (= red) car.
Current rating: 3.2 out of 5.083 votes.
This game has been played 269.812 times.


text:
A série 1150 (1151-1186), conhecida popularmente por Sentinel, foi um tipo de locotractora a diesel da Companhia dos Caminhos de Ferro Portugueses, que continua a ser utilizada pela sua sucessora, a empresa Comboios de Portugal.

Caracterização
Esta série era, originalmente, composta por 36 locotractoras diesel-hidráulicas. Utilizam bitola ibérica, e apresentam uma potência de 250 Cv ou 184 kW, e uma velocidade máxima de 58 km/h. Os rodados possuem uma disposição em C, segundo a Classificação UIC.

Realizam, principalmente, serviços de manobras, por quase toda a rede portuguesa, mas também já rebocaram comboios de passageiros, no percurso entre o Seixal e Barreiro-A, no Ramal do Seixal.

História

Esta série entrou ao serviço entre 1966 e 1967, tendo sido construída pela empresa Sociedades Reunidas de Fabricações Metálicas, com licença da casa britânica  Sentinel. Em 2012, só se encontravam 7 unidades operacionais.

Ficha técnica
 Informações diversas
 Bitola: Ibérica
 Combustível: Gasóleo
 Ano de entrada ao serviço: 1966 / 1967
 Tipo de transmissão: Hidráulica
 Número de unidades construídas: 36
Características gerais
 Potência nominal (rodas):  250 Cv / 184 kW
 Disposição dos rodados:   C
Características de funcionamento
 Velocidade máxima: 58 Km/h

Ver também
Caminhos de Ferro Portugueses

Bibliografia

Ligações externas

1150
Série 1150 da CP
Fundações em Portugal em 1966

redpajama_set_name: RedPajamaWikipedia


Charcoal is a black residue that comes from a burnt piece of plant or a tree. This charcoal, when heated up, gets activated with its' absorptive powers of toxins, chemicals and heavy metals – and this is the product – that we commonly know as the Activated Charcoal. Since centuries, activated charcoal has been serving its' best for several purposes. It has, now, also gone viral for the beauty care purposes that it serves. Nevertheless, one of the best thing that activated charcoal does for us is eliminating health problems when used with drinking water. Read more and know 5 reasons to why you must treat drinking water with activated charcoal.
Filter out the contaminants from the tap water by using activated charcoal. It's considered world's most effective absorbant of toxins, chemicals, and heavy metals.
Activated charcoal is not only an effective water purifier, but also, it does add in minerals to the drinking water. These add-on minerals are effective in detoxifying the body, boost up metabolism, ease digestion and constipation problems, and avail you with several other health benefits.
Water, when filtered with the activated charcoal, tastes pure and fresh. It helps eliminate the bad taste or odor caused by contaminated water. It also works well in transforming grubby, chlorine-treated water into a refreshed drinking water.
Reason 4: Eliminate Bloating and Gas: Activated charcoal helps in getting rid of gastric trouble and bloating in the stomach and intestinal tract. It consists of a million of tiny pores that works like a sponge, soaking in all the gas that's causing discomfort to the body.
Illness and alkaline environment does not go together well. The activated charcoal not only does purify the drinking water, but also it does make it alkaline. Our diet today mostly includes high acid food contents. If you introduce activated charcoal treated drinking water to your regimen, it will help out maintaining body's pH level for healthy human cells.
There are several kinds of activated charcoal. Tablet or stick form are the two popular ones. There are many sources of activated charcoal – coconut shells, bamboo, or various tree branches. PLEASE MAKE SURE the charcoal you buy is not the one that we use for barbeque purposes. It contains many harmful chemicals. You can buy activated charcoal at many local health and food stores. You can also find it online at the amazon store.
Now, when learned with these five reasons to treat your drinking water with the activated charcoal, why not try it out?


and effective in its nature.
We are a Construction & Trade Marketing Company.
Lead by Stephanie Campanella – founding Summit Digital in 2011. We're based in North Sydney right under the Harbour Bridge in the very trendy Industrial Bays on Middlemiss Street.
Big business or small business, your size doesn't matter. What does matter is that you've got a business to run. We'll sit down together to lock in on your customers' needs and understand your business (inside and out). Then I develop a digital marketing strategy to suit your business.
You'll never hear me promise to get you on page 1 of Google or get results within six months.
What I will promise you is the systemised, process-driven approach we'll follow. I will promise the work we will do. And I will promise you that the combination of the two will drive your results… But it takes time.
When we meet, the first thing you'll notice is my enthusiasm and focus. Then you'll probably notice my laugh. At least, that's what I've been told.
My clients also always tell me I'm energetic, determined, and an out-of-the-box thinker. I'd also say I'm an action taker with a laser-like solution-focus.
Let's work together so you can see for yourself.
What else is there to know about Stephanie Campanella?
Check out my LinkedIn profile to find out more about me.


text:
possibility of success in black-and-white
Lou didn't text very frequently, no, but, Pat explained to a friend over after-work micheladas:
"We haven't spent much time together, either. So I can't complain, she doesn't owe me anything."
"What? I feel like I've been hearing about this one for a while."
"Yeah, but still, we haven't actually been in person, like physically together, that much." Pat flattened her straw and pushed it between her two front teeth, like she did when she was a kid and wanted to replicate the cutesy gaps her friends had from their expanders. "I guess I wish it wasn't like that."
"You should've just said that. I thought women were supposed to be more… needy? Especially together. Quick-moving"
"I wouldn't know."
"I didn't mean to make you insecure. I've only had dick, too."
Pat winced.
By the time she got back to her sublet the hot sauce in the drinks had pooled into that familiar weight at the bottom of her stomach. She asked Lou to come over via iMessage as she pissed with the door open. Pat knew that a post-midnight text disregarded her needs. Sleep, for one: her job, a paralegal at her parent's firm (and so, she felt, unearned) robbed her of the hours between nine and five. Meanwhile Lou, an actress, went on the few auditions available in a city whose arts sector had been defunded, a lack of opportunity that blunted her sense of purpose, but gave her any hours she pleased to sleep. There was a bullheaded possibility in their combination: Pat could argue her way into a good performance from Lou, and then, together, they'd present as real girls, in a real world. Like Pat wrote in all the cover letters she'd sent into the void, before her parents took pity on her, she would be eager for the opportunity to walk Lou off life's humiliating carousel—march her, triumphant, away from all that disappointment.
comfort / closeness
Pat told herself that most would mind things ending over text like this, but she didn't. Most days of their n months could be summed up by the danger of wet hands on phones—of Pat living against a desire for more closeness, restraining herself from pushing. "n" could be four, if you counted that month-and-a-halfish during which their "dates" consisted of someone, usually Lou, taking an Uber to the other's, usually Pat's, place. Regardless of the traveler and their destination, Pat would pay. She supposed that they weren't dating then, just taking comfort in each other. So "n" could also be around two. Two months after they'd had that conversation, the what's happening here, that felt both over before it began and like it never concluded.
studied, or better left
"I can't wait to see you"—Pat read it over and over while she waited for her work laptop to restart. It was broken, but she wasn't going to ask her parents for a new one, and the loading bar that crawled across the screen gave her time to get her bearings. She had gone days without hearing from Lou, and the arrival of this message nearly shut down her body. Pat's heart beat fast but weak. Her limbs went numb from the second joint down, her hand limp on the trackpad. She'd never tell anyone about this feeling. She wasn't sure she'd want to hear their diagnosis; she was pretty sure there'd be one. The options were immaturity, traces of preteen crush jitters, or psychological disease, like the kind she might read about in one of her parent's 1970s pseudoscience books. In other words, she was either hopelessly infantile or sick. This had happened before: her past pursuits became one shape when stacked. But this time she would beat back whatever paralyzed her in the face of intimacy. Pat had gone in trying to measure spontaneity against clear-headed rationale. She had been determined to get to Lou and determined that Lou was going to get to her. Their connection (especially the sex) contradicted its origins. That they met online wasn't to be talked about except to be spat on: the nights they spent were too intense to subtend the tacky piece of context that was the app.
why her?
Those nights had been so intense precisely because they unfolded over the flat, gamelike space created by unshared lives and unmeshed context. They'd been Player 1 and Player 2, each with a preordained amount of lesbian XP (leaving Pat scrambling to catch up) and a handful of traits to demarcate their avatars from others available for pairing. They'd taken those presets with them, keeping their interactions on a separate plane, climate-controlled and elevated from reality. They'd done it with drugs, they'd done it with sleep deprivation (sometimes Pat had fallen asleep with Lou's fingers inside of her), and they'd done it after building up an unsustainable amount of tension between each meetings. After bouts of misunderstandings marked by flighty communication, the perennial draw of the six-by-four bed each time they managed to corner each other had drawn a chemical bath of relief that washed, fizzy, over Pat's eyelids and trickled down the backs of her knees. You don't hate me, you wanted to see me after all.
us versus the world, but we want what they have
The ugly exposure of the truth wasn't dissimilar from the time Pat repaired a leather clog with polyurethane glue, not realizing that it would expand into lumpish, foamy bulbs when dry. Instead of their relationship building up from there, its trajectory got more and more confused. They talked about love frequently, but only the concept, not in reference to whatever they had had. At some point, Pat saw, the arc of this relationship had aligned with all the rest.
only one taste of fruit
Pat walked through the park, chewing gum instead of her fingernails, then froze as her eyes alighted on a grey cylindrical bag. Lou was with her father. Pat recognized him from the times they'd scrolled past his face to find some other memory of Lou's on her camera roll, visual presentations with little context, a PowerPoint process of getting to know each other.
Lou claimed she hadn't seen Pat. Pat wondered if Lou was unwilling to test the bond they'd created in the dead of night—thought that maybe Lou wouldn't have acknowledged her had Pat not lifted a hand and beamed. But they'd ended up here, at dinner with Lou's father, Lou thumbing Pat's knee under the table. Pat had always feared that she and Lou wouldn't know what to do with each other in the light of day: that their story would atrophy upon exposure. But this event Pat could take as triumph—proof of some impact she'd made in another's life.
Dinner had quickly become a mistake. Pat panicked through her hangover. Lou's father ordered a plate of bruschetta with smoked cheese, mushrooms and a few, scattered orange slices, naked jewels without their rinds.
"What was your event? Lou said you ran track in college. I ran the 800—was a totally mental game, you had to be a goddamned monk."
Pat chewed on her semi-circles. She'd lied to his daughter. She hadn't sublimated her self-doubt into athletics at university: she had instead spent her time in the library reading anthologies, collections, cultural surveys. Her range had been broad, not deep. Pat had used college to extend her childhood for four years, had let university spit her out onto the beach of thought, where she'd strolled up and down, picking up wet, shining rocks whose fleshy tones dried into something dull and wanting.
"I was on a relay team of sprinters," she ended up saying.
radar, scan on
She hadn't run, anyway. But that's what she had told Lou because it was less shameful than admitting that her development had consisted of an ever-inwards turn. She'd fed Lou the morsels of the activities her mind had been too hostile to allow: all forms of movement, both intellectual and physical. Debate teams and 5Ks and community greenhouses and three-dimensional printers. Pat told these stories to Lou's hairline until she'd fallen asleep on her chest. She had served it as truth so long that she could almost forget it wasn't. Now Lou was ending things, and Pat hadn't even considered that their relationship could dissolve before her story did—she hadn't done anything wrong, and so even this collapse hadn't been something done, completed, or even chosen. Like everything else, it had happened without her. At least there was a comforting thematic neatness to Pat and Lou's series of events: they had begun online, and now they were disappearing in the same space. Not even a stitch needed to close the gap. It would all be fine. That was the problem.
this story is nothing new
bessie rubinstein
Bessie is a writer, caretaker, and arts worker living in Brooklyn with their pet snake and organising with their fellow tenants


Tennis Elbow is very annoying, so it is important to know what is the best treatment for this condition and improve your quality of life.
Tennis Elbow is not more than a tendititis in the area of the elbow and that usually is denominated of popular form like elbow of tennis player. Today it is a problem quite common in much of society and should be treated with great speed so that the thing does not go over. Today sit is usually treated by infiltrations of cortisone, which helps reduce pain in the short term but in the long term the problem remains causing the person to have sequelae for life.
If you have tennis elbow, it is normal to have intense pain in the entire area of the elbow. It is undoubtedly the most common symptom of the tennis elbow. Just by picking up a glass , the person feels a strong pain on the outside of the elbow causing a continuous discomfort. If the discomfort persists over time and occurs without any movement, it is likely that the problem of such tendinitis is of cervical origin.
One of the most common causes for which the person may suffer the so-called tennis elbow is due to constant physical activity such as working on an assembly line. For many hours a day, the person forces the tendons of the elbow leading to this problem. People who tend to play tennis tend to suffer from this tendinitis when performing continuous movements with the arm and forearm, overcoming the muscles of that area of the body. Some fall or blow can also be the cause of this intense pain in the elbow area.
A first measure when dealing with a problem such as Tennis Elbow is cryotherapy or ice application. With the cold the inflammation in the tendons of the elbow is reduced and immediately a little heat is applied to reduce the pain in the whole area . The second step of the treatment is the total rest for a few days that the person suffering from said tendinitis should have.
Other measures that are usually taken to treat Tennis Elbow is the use of different anti-inflammatory products either topical or ingested. Elbow Physiotherapy or rehabilitation exercises are another type of ideal measures when treating this condition in the elbow. Call the best physiotherapist in Melbourne today at Physio AUS.
As I have already mentioned, there is a bit of controversy about the use of cortisone infiltrations since, although in the short term they help to reduce pain, over time the problem does not disappear and it gets worse. In extreme cases of Tennis Elbow, a surgical operation may be performed in order to release the tendon from the bone.
When it comes to preventing any type of problem in the elbow area, it is best to perform a series of well-executed movements that do not push the tendons to the limit. In addition, after performing some type of activity that is constant in the elbow area, it is advisable to restto avoid any kind of muscular problem . On the other hand stretching and previous massage are very beneficial to not suffer from such tendinitis.
Tennis elbow or epicondylitis is a condition very present in a part of the population that must be treated very quickly by an expert in the subject to prevent the tendinitis is aggravated much more and the person in question end with important sequelae in a future.


The Insolvency Service has published its performance ratings for the first quarter of the 2014-15 year, showing strong satisfaction for those undergoing personal or business insolvency during the period.
At what is undoubtedly a stressful time for many people, the figures show how, for its part, the Insolvency Service works to make sure people are kept 'in the loop' and treated fairly.
In 95.7% of cases, customers were either satisfied or very satisfied with the service; 98.4% found the Insolvency Service's staff to be polite or very polite; and 97.4% found them helpful or very helpful.
An impressive 99.9% of telephone interviews were carried out within five minutes of the agreed time, and an even more impressive 100% of unscheduled visitors were dealt with within ten minutes of arrival.
The figures show how those undergoing personal or business insolvency are treated with respect, and given the best level of service possible.
For anyone putting off seeking administration advice due to concerns about being treated poorly, this should serve as proof that you will not be treated as 'just a number', but as a person who deserves a courteous and professional service.


Each year, over 700 million people around the globe relocate to a different country. The key to a successful move is finding the right long distance movers.
Selecting a mover for long-distances is different than choosing someone to help with a local move. There are several things to consider and if you don't know what you are looking for, then finding the right service provider could be a considerable challenge.
You need to find out if the mover you want to hire is licensed and registered. Check the movers' public record to determine if there are any safety violations recorded.
Also, find out about international insurance if they are handling your move to a different country.
Once you have a short list of registered relocation services, you need to run a check on them at your local trading standards office.
You can find out what businesses and actual customers have to say about your potential mover. It is also wise to find out if the mover has any professional affiliations in the moving industry.
When moving to a different area in the same country or to an entirely different one, experience counts. Finding an established company is essential.
Interstate and international moving require several considerations that local moves don't. You have to follow all international regulations, and your risk also increases.
Your cargo is traveling further, which means you need a team of movers who can handle the process.
Cost is an important factor when choosing a moving service. However, you need to do more than compare prices when choosing a company.
Request a detailed quote, in writing from the mover you consider using. Read the estimates carefully to ensure they include everything involved with the move in the price.
Unfortunately, the moving business is full of "fly by night" companies and scam artists. To make sure you don't become a victim of this situation, look for red flags that indicate a company isn't legitimate.
Be sure to avoid companies that insist on a large deposit or cash before your move. Also, stay away from companies offering estimates over the phone or online.
Don't ever use a moving service that shows up in a rental truck or without a written estimate; they're big red flags. Don't ignore them.
If you are planning a long-distance move, use the tips here to find the right company. Moving can be stressful, but the right professionals can make it much easier.
To learn more about hiring a long-distance mover, contact us at Removals Companies to learn more. We provide the resources necessary to make an educated decision regarding what mover to hire. Don't forget these questions when you are looking for international moving quotes.


text:
Manuel Seminario Saenz de Tejada (* París, 4 de mayo de 1884 - † Guayaquil, 15 de enero de 1966) sus amigos y conocidos le decían "Don Meme" y fue un dirigente deportivo ecuatoriano, reconocido por ser el promotor de la actividad deportiva en Guayaquil fundador de la primera entidad multideportiva del Ecuador Liga Deportiva de Guayaquil fundada el 6 de mayo de 1911 siendo esta la antecesora de la Federación Deportiva del Guayas que se fundaría el 25 de julio de 1922 impulsor de la resurrección de clubes antiguos como el Club Sport Guayaquil de 1899, fundador de nuevas entidades deportivas, gestor del primer torneo federativo interclubes de Fútbol que se disputó en Ecuador, iniciador de los primeros encuentros Interprovinciales, promotor de la fusión entre la Liga de La Concordia (Asociación de Clubes que no pertenecían a la FDG) y la Liga del Puerto Duarte  y primer ecuatoriano en ocupar una dignidad internacional como la de ser consejero de la FIFA.

Vida
Nació en la legación de Ecuador en París , su padre fue el ecuatoriano José Ezequiel Seminario -aparece como vicecónsul a la época en que fue publicado el Ecuador en Chicago, año de 1892- que en ese momento ejercía el cargo de embajador y ministro plenipotenciario, y de madre guatemalteca. Se educó en colegios exclusivos de Francia, Alemania e Inglaterra en una época de gran auge deportivo. Se destacó como futbolista, jugador de Hockey sobre césped y atleta, rama deportiva donde se consagró campeón de los 100 metros planos del condado de Kent en Londres.
En 1903 se fundó la entidad de mayor trascendencia social de Guayaquil la Asociación de Empleados gestada por Virgilio Drouet, hombre que también tenía inquietudes deportivas pues era fomentador y practicante de la pelota vasca y el críquet.
En 1906 Drouet propuso a sus con-socios para crear el Centro Deportivo Asociación de Empleados. Manuel Seminario que había llegado a Guayaquil en 1907 y con tan solo 23 años estaba decidido a fomentar el fútbol, buscó a una entidad deportiva a la cual afiliarse encontrándose que sólo sobrevivía a medias el Club Sport Guayaquil en el que militaban sus amigos Juan Alfredo y Roberto Wright famosos Guayaquileños quienes trajeron del primer balón de fútbol al Ecuador. Sus amigos, los hermanos Wright lo vincularon a la Asociación de Empleados, entidad gremial que hacía actividad deportiva como la esgrima, el tiro, el levantamiento de pesas y el atletismo. Manuel Seminario se reúne con Drouet que ejercía como vicepresidente, quien estaba empeñado en popularizar el críquet y Rafael Piedrahíta presidente de la Asociación creando así el Association Foot Ball Club representante oficial de la entidad gremial, aunque en los años posteriores se lo identificó con las siglas ADE de la Asociación de Empleados.
Manuel Seminario estaba consciente que para promover el fútbol debía impulsar otros equipos y convenció al Club Sport Guayaquil para reiniciar sus actividades, al Igual que al Club Sport Ecuador. Convenció a los jóvenes que formaban dos pequeños clubes , el 24 de Mayo y el Abdón Calderón para que se fusionaran y fundaran el Club Sport Unión que llegó a ser una de los más famosas oncenas de las primeras décadas del siglo XX. A instancias suyas, los estudiantes vicentinos  se agrupaban en el recién fundado Club Sport Vicente Rocafuerte. Creó el Club Universitario, integrado por estudiantes de Medicina y Derecho aficionados al fútbol de la Universidad de Guayaquil, siendo esta la primera institución deportiva que nacía en el seno de una entidad universitaria y que en años posteriores se replicaría en todo el Ecuador. También logró que la Armada Nacional patrocinara la fundación del equipo Libertador Bolívar formado por artilleros del cazatorpedero del mismo nombre.
El 8 de agosto de 1908 había conseguido que el Municipio de Guayaquil habilitara canchas de futbol en la Plaza del Progreso (hoy Parque Chile), La Atarazana, el antiguo hipódromo, la Plaza Victoria y el Jockey Club.
El 19 del mismo mes el directorio del ADE dictaminó que el primer equipo de fútbol debute el domingo 23, a las 8 de la mañana en la Plaza del Progreso (Parque Chile) frente al equipo del Libertador Bolívar. Aquel día Manuel Seminario hizo de jugador y entrenador en ADE donde ganaron por el marcador de 2 a 1. Luego del partido el directorio de ADE se reunió y acordó elegir un terreno amplio y adecuado previo apoyo de la Municipalidad de Guayaquil el establecimiento de un Campo Deportivo Público, el sitio escogido fue el antiguo Hipódromo.

Primer Torneo de Fútbol

En Guayaquil funcionaba desde 1906 el llamado Comité 18 de Septiembre institución que se dedicaba a solemnizar la fecha de independencia de Chile en la ciudad. El 17 de septiembre de 1908 dicho comité había donado una copa para celebrar las fiestas de dicho país. Los equipos que iban a participar eran ADE, C.S Unión, Libertador Bolívar y Club Sport Guayaquil. En la Plaza Abdon Calderón (Plaza Victoria) se celebraron los encuentros en la mañana del 18 de septiembre. El Libertador Bolívar ganó 1 a 0 al ADE mientras que el Unión fue derrotado por el Guayaquil con el mismo marcador. En la tarde se jugó la final entre Guayaquil y Libertador siendo vencedor el primero por un marcador de 2 a 0.

Primer Torneo de carácter oficial
El 28 de septiembre de 1908 se hizo público que la Municipalidad de Guayaquil había acordado auspiciar el primer torneo de fútbol con carácter oficial encomendando la organización de dicho torneo a la Asociación de Empleados. El torneo sería ganado por el Club Sport Guayaquil equipo que integró Manuel Seminario venciendo 2 a 0 al C.S Ecuador en la cancha del Jockey Club. En los meses restantes de 1908 la actividad deportiva no decayó. La semilla sembrada por Manuel Seminario siguió dando sus frutos.

Campeonato de Guayaquil de 1909
El entusiasmo que había provocado el primer torneo hizo que en 1909 se inscribieran más equipos para disputar el campeonato, certamen que era organizado por Manuel Seminario con la colaboración del Centro Deportivo Asociación de Empleados. Los elencos que participaron son Club Sport Guayaquil, ADE, C.S Unión, C.S Sucre y C.S Libertad, se unieron Universitario, C.S Vicente Rocafuerte, Chile y el Santiago que se había fundado el 13 de agosto siendo también el mismo año donde el Club Sport Patria hace su debut. El 10 de octubre se jugó la final del torneo donde el Club Sport Guayaquil derrotó al C.S Unión por 2 a 0 conservando el cetro que había ganado el año anterior.

Primeros encuentros Interprovinciales y fundación de la Liga Deportiva Guayaquil
El 6 de mayo de 1911 se fundó la Liga Deportiva Guayaquil, antecedente de la Federación Deportiva del Guayas y siendo esta la primera entidad multideportiva del Ecuador, obra del incesante Manuel Seminario. La Liga Deportiva Guayaquil para mayo de 1912 ya había organizado su primer torneo de Fútbol, Manuel Seminario tomó la iniciativa de realizar los primeros cotejos interprovinciales entre los clubes de Guayaquil y Quito. Seminario había nombrado a un representante para que hiciera contacto con el Club Sport Quito, el club deportivo más grande y el primero fundado en esa ciudad, para llevar a cabo los deseados choques interprovinciales. El diario La Prensa de Quito señaló que el 24 de mayo se daría el primer choque "regional", encuentro que tuvo que esperar hasta el 10 de agosto. Manuel Seminario aprovechando ese lapso de tiempo decidió realizar encuentros eliminatorios entre clubes guayaquileños. Finalmente el Club Sport Guayaquil sería el ganador de la eliminatoria para representar al futbol porteño.
El 1 de agosto en la mañana a bordo del vapor "Balao" se dirigió la delegación del Club Sport Guayaquil a Duran para tomar el tren que lo llevaría a Quito. Entre los jugadores del representativo Guayaquileño se encontraba Manuel Seminario. El 10 de agosto en el Ejido el llamado Team Guayaquil vapuleó por 4 a 0 a su rival el Club Sport Quito.
Luego de la victoria del elenco Guayaquileño se pactó un nuevo encuentro que se desarrollaría en las fiestas octubrinas. La revancha iba a tener como escenario la cancha ubicada en el antiguo Hipódromo al sur de la ciudad. El 12 de octubre de 1912 a las 8 de la mañana comenzó el juego ante 6000 aficionados, Manuel Seminario integraba la plantilla del Club Sport Guayaquil, el encuentro fue muy reñido pero el marcador no se movió. Terminado el juego ambas delegaciones se dirigieron al Hotel Guayaquil donde después de brindarse una copa de champaña se sirvieron un suculento almuerzo criollo. Terminado el ágape Manuel Seminario entregó a Rafael de la Torre -Presidente del C.S Quito- una copa de plata que había sido donada por la Municipalidad de Guayaquil. Una invitación a la fábrica de cerveza de Eduardo Gallardo y un banquete en el Club de la Unión cerraron las celebraciones de los primeros encuentros de fútbol "inter city" como lo llamó un diario de la época.

Fundación de la Asociación de Football
A fines de julio de 1915, ante la desaparición de la Liga Deportiva Guayaquil, Manuel Seminario propuso la fundación de la Asociación de Football, entidad que tenía como fin organizar los campeonatos de fútbol en la ciudad. A su fundación concurrieron varios clubes entre ellos el Club Nacional que se alzaría con el campeonato de ese año derrotando por 3 a 0 al C.S Unión. En 1916 el Club Nacional revalidó su título conseguido el año anterior derrotando al C.S Oriente. Desde 1918 a 1920 no se realizaron campeonatos debido a la desaparición de la Asociación. Dando paso a la creación de la Liga Ecuador entidad a la que se habían integrado varios clubes entre ellos el Club Sport Norte América. Los encuentros se los disputaba en canchas de tierra de la Plaza La Concordia (Hoy Piscina Olímpica).

Fundación de la Federación Deportiva del Guayas
En 1922 el deporte en Guayaquil había alcanzado un importante desarrollo pues se practicaban casi todos los deportes y existía al menos un centenar de clubes en las diversas ramas deportivas. Sin embargo la ausencia de entes del voluntariado deportivo se notó más cuando el 15 de junio de 1922 el El Telégrafo publicó una nota periodística en la que se señalaba que el profesor Franz Kopper, un alemán que trabajaba en Quito, estaba empeñado en que Ecuador concurra a los Juegos Olímpicos de Brasil que no era otra cosa que unos Juegos Internacionales Latinoamericanos por el centenario de independencia de ese país, que el Comité Olímpico Internacional había resuelto poner bajo su patrocinio. Ante esta situación, surgió la inquietud de formar en Guayaquil una Federación que agrupara a todos los deportes y pusiera en manos del voluntariado deportivo la dirección de esta actividad, como sucedía en todos los países del mundo. A la cabeza de este movimiento se encontraba Manuel Seminario Sáenz de Tejada, quien había iniciado contactos con dirigentes deportivos franceses para consultarlos sobre las formas mejores de organización deportiva. Dando origen a la Federación Deportiva Guayaquil siendo su fundación el 25 de julio de 1922 y en 1924 cambia de nombre a Federación Deportiva del Guayas ampliando su rango de acción con miras a la constitución de la F.D. Nacional del Ecuador (Fedenador).

Inauguración del Campo Deportivo Municipal
El 8 de octubre de 1923 se aprobó por parte del Concejo de Guayaquil la creación de la Junta Deportiva Municipal para cuyo efecto el Municipio destina cien mil metros cuadrados de terreno en la parte de la ciudad denominada Puerto Duarte sobre el lado oeste del estero del mismo nombre.
Los terrenos eran los mismos en que la Federación Deportiva Guayaquil había habilitado una cancha de tierra y levantado una rústica tribuna y donde se habían realizado los torneos de 1922 y 1923. La Federación estaba presidida por Manuel Seminario, quien encabezó una campaña por levantar un estadio alrededor de la cancha, obtuvo un préstamo del Banco Territorial (entidad Guayaquileña que desapareció en 2013) cuando era Gerente Julio Guzmán Aguirre. Se procedió a aplanar en mayo de 1924 la sarteneja dejada por el invierno y a edificar una tribuna de madera más amplia y consistente de la que ya existía.
El 8 de octubre de aquel año se inauguró el llamado Campo Deportivo Municipal, el primero con pista de estadio que tenía Guayaquil, con un partido entre las selecciones de Guayaquil y Ambato que iban a participar en la segunda disputa del Escudo Cambrian que sería ganado por el elenco porteño al derrotar en la final al seleccionado quiteño por 1 a 0 .

Afiliación a la FIFA
Es decisivo el papel que en el desarrollo de nuestro deporte y del fútbol tuvo Manuel Seminario Saenz de Tejada desde su llegada a Guayaquil en 1907. No solo fundó la Federación Deportiva Guayaquil que en 1924 pasó a llamarse Federación Deportiva del Guayas entidad que sobrevive hasta nuestros días, sino que a fines de 1923 decidió aprovechar sus contactos en Francia país donde había nacido y donde realizó buena pàrte de sus estudios. Su interlocutor epistolar fue Franz Reitchel, quien había sido su condiscípulo durante las secundaria en París y ejercía las funciones de secretario del Comité Olímpico Internacional y de la Federación Francesa de Deportes Atléticos. La Intención de Seminario al contactar a Reitchel tenía 3 objetivos:
Lograr la autorización para que Ecuador concurra a los Juegos Olímpicos de París; buscar asesoría para fundar una Federación Deportiva Nacional y conseguir la afiliación de Ecuador a la FIFA.
Seminario logró la inscripción de tres atletas en los Juegos Olímpicos e inició las consultas para fundar la Federación Deportiva Nacional. Los atletas viajaron a París y participaron en los Juegos mientras Seminario impulsaba y asesoraba a los dirigentes quiteños y riobambeños para fundar las respectivas federaciones provinciales. Ante la FIFA Seminario continuó sus gestiones las que fructificaron pronto de acuerdo a lo que este contara en la carta que se publicó en el diario La Nación el 20 de septiembre de 1950.

En 1927 Seminario fue nombrado Consejero de la FIFA, según lo reportaron los diarios de la época, con lo que se convirtió en el primer ecuatoriano en ostentar un cargo en el deporte internacional

La tecnificación de nuestro Fútbol
¿Cuándo empezó la real tecnificación de nuestro fútbol? En esto tuvo, como en todo lo que se relaciona al deporte guayaquileño y nacional un papel decisivo Don Manuel Seminario Sáenz de Tejada. En 1925 Seminario advirtió la necesidad de traer a Guayaquil un técnico de fútbol con prestigio que entregue a nuestros futbolistas ideas claras para su progreso. Expuso esta idea, a inicios de 1925, a otro personaje singular;  Mr John Urquhart, cónsul de Inglaterra en Guayaquil. El diplomático llegó a nuestro puerto en 1920, apenas arribado se vinculó al C.S Oriente. Era arquero del equipo Anglo Ashton que en 1925 llegó a la final del torneo de la Unión Deportiva Comercial contra el Emelec. En 1924 presidió el Comité Cambrian que organizaba la disputa del Escudo del mismo nombre. Conservó la presidencia hasta el final de la disputa del Escudo en 1931. El diplomático buscó en su tierra un profesional que estuviera dispuesto a permanecer unos meses en Guayaquil y no tardó en encontrarlo. El 5 de junio de 1925 llegó el primer entrenador extranjero Mr Herbert Daynti contratado por la Federación Deportiva del Guayas. Daynti había sido centro medio del equipo Dundee Football Club a su llegada fue conducido al Campo Deportivo Municipal para que pueda presenciar las cualidades de quienes iban a ser sus dirigidos, regresando a su país en diciembre del mismo año.

Véase también

 Fútbol en Ecuador
 Federación Ecuatoriana de Fútbol
 Liga Profesional de Fútbol del Ecuador
 Selección de fútbol de Ecuador
 Selección femenina de fútbol de Ecuador
 Serie B de Ecuador
 Segunda Categoría de Ecuador
 Copa Ecuador
 Supercopa de Ecuador
 Serie A Femenina de Ecuador
 Campeonato Amateur de Guayaquil

Referencias

Fútbol en Ecuador
Dirigentes de fútbol
Personas de Guayaquil
Fallecidos en Guayaquil


text:
St. Andrew Parish Announces 2022 Martin Luther King, Jr. Awards
Tony Jones was honored with the 2022 Parish Service Award, and the award for Community Service went to Terrance Moses Read More
For the first time, people across the U.S. can log on to a government website and order free, at-home COVID-19 tests. But the White House push may do little to ease the omicron surge Read More
Washington Students' Test Scores Drop Significantly
Reports show that between 2019 and 2021, the overall percentage of students who met state standards on the math portion of the exam fell by 20 percentage points. Read More
The Skanner Foundation Drum Major for Justice 2022 is Teressa Raiford
Through political campaigns, legal actions, founding the grassroots organizing group Don't Shoot Portland and through her fearless determination to speak up against racial injustice, Portland-born Teressa Raiford has made a lasting impression on our city and our state Read More
NORTHWEST NEWS
Reports show that between 2019 and 2021, the overall percentage of students who met state standards on the math portion of the exam fell by 20 percentage points.
Through political campaigns, legal actions, founding the grassroots organizing group Don't Shoot Portland and through her fearless determination to speak up against racial injustice, Portland-born Teressa Raiford has made a lasting impression on our city and our state
Paid Workplace Training Internships Program Receives Support From City
Black, Latinx students receive skilled on-the-job training, career coaching, through POIC-RAHS program
Oregon Supreme Court OKs Dropping Bar Exam for Alternatives
The state's highest court in a unanimous vote "expressed approval in concept" to a pair of alternative pathways designed for law students and postgraduates seeking admittance to the state bar
Revamped TriMet Website Makes Planning Trips Easier With Map-Based Tools
Riders can now track real-time locations of buses and trains on their smartphone ...
PHOTOS: Founder of The American History Traveling Museum: The Unspoken Truths Honored
Delbert Richardson's Alpha Phi Alpha, Alpha XI Chapter fraternity brothers presented him a plaque that reads "Your commitment to...
Tony Jones was honored with the 2022 Parish Service Award, and the award for Community Service went to Terrance Moses ...
Culture + Trauma: An Artist Comes Home
An installation at the Alberta Arts Salon curated by Bobby Fouther is a visioning of the uncensored Black life. ...
MLK Day March Starts at Peninsula Park
Humboldt Neighborhood Association invites the public to participate in the March for Human Rights and Dignity in commemoration of the...
Portland pays .5K to settle protest lawsuit
PORTLAND, Ore. (AP) — The City Council in Portland, Oregon, on Wednesday approved paying ,500 to settle a lawsuit brought by a woman who said police used excessive force against her during the 2020 protests that wracked the city. The settlement is the latest in a string of...
Lawsuit says new majority Latino district in WA a 'facade'
SEATTLE (AP) — A Latino civil rights organization and others filed a federal lawsuit Wednesday that says new political maps in Washington state approved by a bipartisan redistricting panel intentionally dilute Hispanic voters' influence. The legal action in the U.S. District Court...
UNLV promotes interim AD Harper to full-time job
LAS VEGAS (AP) — UNLV has promoted interim athletic director Erick Harper to serve in the job full time. Harper's hiring, announced on Monday, was effective Jan. 1. He had served as interim athletic director since Desiree Reed-Francois left UNLV for Missouri in August. ...
Army stuns Missouri in Armed Forces Bowl on last-second FG
FORT WORTH, Texas (AP) — Cole Talley kicked a 41-yard field goal as time expired and Army rallied to beat Missouri 24-22 in the Armed Forces Bowl on Wednesday night. After the Tigers took a 22-21 lead on a touchdown with 1:11 to play, third-string quarterback Jabari Laws led Army...
OP-ED: A House Divided Against Itself Cannot Stand
January 6th, Voting Rights and the Tyranny Threatening America ...
Support Nikole Hannah-Jones and The 1619 Project
This important and ambitious project pulled back the curtain of euphemistic rhetoric composing American historiography that points only to the good in our history and sweeps under the rug the evil deeds perpetrated against people of color ...
In 2021, Organized Labor is Again Flexing its Muscles
We have seen dramatic change in the makeup of the National Labor Relations Board (NLRB) under President Biden. ...
Study Reveals Racial Pay Gap for Social Media Influencers
The racial pay gap has long presented issues for African Americans in Corporate America and other industries. It's now filtered to social media. ...
AFRICAN AMERICANS IN THE NEWS
MINNEAPOLIS (AP) — A timeline of key events that began with George Floyd's arrest on May 25, 2020, by four police officers in Minneapolis: May 25, 2020 — Minneapolis police officers respond to a call shortly after 8 p.m. about a possible counterfeit bill being used at a corner...
OKLAHOMA CITY (AP) — A former Oklahoma jailer has pleaded guilty to violating an inmate's civil rights by kicking and striking him in a 2020 assault, federal prosecutors said Wednesday. Johnnie Drewery, 27, faces up to 10 years in prison when he's sentenced in a few months, the...
WASHINGTON (AP) — Senators faced off in emotional, raw debate Wednesday on voting legislation that Democrats and civil rights leaders say is vital for protecting democracy but that almost certainly will be defeated without a filibuster rules change, in what would be a stinging setback for...
Amazon's untitled 'Lord of the Rings' forges itself a name
LOS ANGELES (AP) — Amazon's "The Lord of the Rings" series has forged a name for itself. "The Lord of the Rings: The Rings of Power" was announced Wednesday as the full title of the drama set to debut Sept. 2, with episodes to be released weekly on the streaming service. ...
Review: Mellencamp album reflects on life and wasted time
"Strictly a One-Eyed Jack," John Mellencamp (Republic Records) John Mellencamp's latest studio album, "Strictly a One-Eyed Jack," is a work of deep reflection. Over the course of 12 new tunes, Mellencamp sings in a raspy sing-song voice mixing blues, folk, and...
NEW YORK (AP) — Cardi B has offered to pay the burial costs for all 17 people killed in a fire that ripped through a New York City high-rise. New York City Mayor Eric Adams announced Wednesday that the Grammy-winning rapper had offered the financial relief for victims of the fire in...
PBS and MPT Announce Two New Documentaries Executive Produced by Acclaimed Filmmaker Stanley Nelson for Fall 2022
The Tragedy of Macbeth Film Review
Ava Duvernay's 'Naomi' Series Aims to Aspire a New Generation of Black Girl Superheroes
Final Valuation of Prince's Estate Pegged at $156.4 Million
Nonprofit AGE+ Recommends Ways to Celebrate Martin Luther King Day
Biden Nominates 3 for Fed Board, Including First Black Woman
NEW YORK (AP) — The New York attorney general says her investigators have uncovered evidence that former...
WASHINGTON (AP) — President Joe Biden said he believes Vladimir Putin doesn't want full blown war in Ukraine...
CRAIG, Colorado (AP) — In a quiet valley tucked away from Colorado's bustling ski resorts, far from his...
Canadian fashion mogul Peter Nygard denied bail in Toronto
TORONTO (AP) — Canadian fashion mogul Peter Nygard has been denied bail and will be detained in Toronto as he...
PARIS (AP) — A spattering of Paris Fashion Week menswear shows began in earnest this week for the fall-winter...
TRIPOLI, Libya (AP) — The head of Libya's national oil company said on Wednesday that his country is targeting...
Brian Stimson of The Skanner News
The Portland Trail Blazers and Winterhawks released their official concept for the redevelopment of the Rose Quarter and Memorial Coliseum on Friday.
The Trail Blazers have been pushing the concept for "Jumptown" – a 365 days a year entertainment, shopping and cultural district in the Rose Quarter – for months now. The final concept includes a plan for a renovated Coliseum; a community athletic center; a meeting space designated specifically for veterans' groups; and a mixed-use development that would include restaurants, office, retail, housing and more.
It is unclear how much the Trail Blazer proposal will cost the team or city. According to spokesperson Bill Evans, the next phase of the project will include financial considerations, once the Rose Quarter stakeholder advisors committee has heard all proposals for the district.
In addition, sketches of the proposal include long term plans to turn the property currently occupied by the Portland Public Schools' administrative building into residential housing.
The Trail Blazers have joined with the Cordish Companies to help design the concept. Cordish are responsible for bringing mixed use development to at least 7 similar sports arena districts.
The Coliseum proposal includes a modified bowl to create a more intimate viewing experience and allow more natural light; a new NHL regulation ice rink; the aforementioned athletic facility that will be open to accommodate low-income people; and other upgrades.
Project developers propose using existing LEED environmental building standards, electrical vehicle charging stations, transit oriented design and a potential farmer's market.
about-sports-basketball
about-Portland-Trailblazers
about-basketball
about-Portland-Trail-Blazers
about-sports


Think you can you outwit Jarhead? Are you brave enough to face an automatic lock-in situation?
Producers of unique gameshow The Crystal Maze is on the hunt for contestants from Devon to appear on the next series.
According to their website, producers of the show are on the look out for 'terrific teams to tackle the ultimate time-travelling adventure'.


text:
Chicago, Destinations, Museums, Memorials & Landmarks, USA
Ernest Hemingway's First Chapter in Oak Park, Illinois
Where it all began for Ernest Hemingway
chicago, hemingway, museums, oak park
Arizona, Destinations, North America, Sweeney in Arizona, USA
Musical Journeys Around the World at MIM Phoenix
MIM – The Musical Instrument Museum of Phoenix
Arizona, featured, museums, north america, phoenix, united states
Arizona, Sweeney in Arizona, USA
Scottsdale is for Art Lovers: Top Museums and Venues
Art lovers! Don't miss these places and spaces to discover the diverse art of Scottsdale, Arizona and the Valley of the Sun.
Arizona, museums, scottsdale, USA, wine
Arizona, Destinations, Sweeney in Arizona, USA
Spirit Matters at Scottsdale's Museum of the West
Western Spirit is a first-class museum in Scottsdale, Arizona, celebrating the art, culture and history of the American West.
Arizona, Art and Architecture, culture, featured, museums, scottsdale, USA
Arizona, Destinations, Museums, Memorials & Landmarks, Sweeney in Arizona, USA
Heard Museum: A Cultural Highlight in Phoenix
Since its opening in 1929, the Heard Museum has been showcasing unique and diverse collections of American Indian art and artifacts and currently has 40,000 objects in its 12 galleries.
Arizona, Art and Architecture, museums, phoenix, USA
Attractions, California, Canada, Destinations, Museums, Memorials & Landmarks, New York, Ontario, USA, Wisconsin
From Shoes to Sex: 14 Intriguing Museums in North America
While I enjoy visiting large institutions like the Field Museum of Natural History in Chicago or the Metropolitan Museum of Art in New York City to peruse their enormous collections, I have a special fondness for the smaller, and in some cases unusual or under-the-radar museums that I come across.
Art and Architecture, museums, north america


Martin O'Neill's side earned a late victory against the United States of America.
Email "Player ratings: How the Boys in Green fared against the US".
Feedback on "Player ratings: How the Boys in Green fared against the US".


text:
Home Arkansas Blog Pediatrician talks about COVID-19 symptoms, recovery and release
Pediatrician talks about COVID-19 symptoms, recovery and release
Leslie Newell Peacock
Brian Chilson
Dr. Ashley Courtney, who has recovered from COVID-19.
On April 11, 17 days after Dr. Ashleah Courtney was sent home from Arkansas Children's Hospital because she'd been exposed to a person with COVID-19, she and her husband, Paul Dickson, got the OK to leave isolation.
"We went and picked up wine and beer, and got cookie dough from Loblolly, and went to Slim Chickens … . We're the worst," she said, laughing. "And we got Lost Forty's Flake Baby strawberry brunch rolls. … Oh, and we got one of the cocktail kits from Local Lime. I've never been so happy to be in the car."
Courtney is a third-year pediatric resident who was working in the ER at Children's (masked, following Centers for Disease Control and Prevention guidelines) when she was told she needed to quarantine. It was March 26. "I had a bit of a sore throat and a headache" that day, she said, but she attributed it to pollen and the fact that when she's in the ER she forgets to eat and stay hydrated. "So it was not out of the ordinary," she said.
But at around 3 a.m. on the following morning, "I was having trouble sleeping and was checking my temperature every hour, and eventually it got to 100.4." She called the COVID-19 screening hotline at the University of Arkansas for Medical Sciences.
"At that point, we were still pretty limited [on tests]. I'm a healthy 30-year-old and I didn't want to take a test from someone who needs it," but because she is a health care provider — a priority group for testing — she was advised to come through the testing drive-through, which UAMS created out of a converted parking garage to handle the thousands of Arkansans who wanted to know if they'd been infected.
When she got to the drive-through, "my temp was normal, which was weird," she said. But as a resident physician, she needed to be tested. The "swabber," as UAMS calls the nurses wielding the test swabs in the drive-through line, explained to Courtney that she would be inserting the swab up her nose and into the back of her nasal passages. "And I said, 'Oh, I do this to small children all the time,' " to which the swabber replied, " 'Then this is your payback.' "
"I was told it would be 14 days of quarantine regardless of whether I showed symptoms. It took two days to get the results." When she found out she had COVID-19, she posted about her diagnosis on Facebook. An excerpt:
"I was being cautious around all of my patients at work. And I was especially excited about the prospect of volunteering/shadowing one of my infectious disease mentors at the health department next month to help with contact tracing for the virus. I thought we were doing things right. Then, I was officially sent home and placed under quarantine (and Paul by association, of course). …
"The medical and public health side of me knows that statistically we will probably be okay. But the human in me is totally not okay. The human side of me has emotions running in about 100 different directions. I'm anxious about what our illness will look like over the next week. I feel guilty about exposing my husband, even though it wasn't a surprise and was something we knew would happen eventually. I feel angry that I was exposed so soon. I feel isolated and stigmatized. I don't want people to look at the positive numbers and make the blanket assumption that we haven't done everything we could to avoid this.
"I was going to say the biggest thing I ask of you all is encouragement. But that's not entirely true. The biggest thing I'm going to ask of you is to listen to the experts. Please if you take nothing else from what I've said, realize how incredibly important social distancing and self isolation is in our fight to prevent the further spread of this virus."
Courtney and Dickson, a civil engineer, had talked about what they believed was the inevitability of getting the new coronavirus. Courtney is headed to New Orleans — a hot spot for the disease — in June to do a fellowship in pediatric infectious disease, and the couple were thinking infection was preordained, that it would "happen regardless. … I was just surprised it happened so soon."
"The first 12 hours were probably the worst, with fever and muscle aches and chills. The cough came later," she said. Though her husband was not tested, like Courtney he suffered cough, fatigue and body aches. "It was just shocking how dramatic the loss of taste was. For a week. … It's just very odd to eat when you can't taste anything." She lost six pounds.
The most difficult thing about her illness, she said, was anxiety. In early April, three resident physicians in the U.S. had died of the virus. "I was worried when one of us would start showing [severe symptoms]," which usually occur around five to 10 days after infection. For her mental health, she decided to limit how much she read about the illness, and was relieved when she and her husband passed the halfway mark with no greater sickness.
Some people have turned to hobbies, like knitting or gardening, to pass their isolated hours. Courtney's hobbies? "Going out to eat," she said, sighing. "That was one of my hobbies."
Like the rest of the world, Courtney and Dickson turned to Netflix to endure their lockdown, finding distraction in "Tiger King" and "Ozark."
Though she knew she needed to quarantine, and in her Facebook post urged people to take COVID-19 seriously, Courtney said she felt a "little guilty" not working. "I think health care providers feel a sense of duty."
Though she feels well, has been symptom-free for some time and her third COVID-19 test was inconclusive, a fourth test in mid-April showed some virus still remained. She was not surprised. In the case of rhinoviruses, "if you reach back into the depths of someone's nose two and a half inches," which is the length of the swab, she said, you'll find evidence of virus for a long time. COVID-19 tests, which analyze RNA, are particularly sensitive.
Still, she'll have to test negative before she can return to work, and before she can donate plasma, which she wants to do. It's hoped that plasma with COVID-19 antibodies can help people with the disease recover, and if that is the case, her plasma would be invaluable in coming months: She moves to Louisiana in June, which as of April 20 had nearly 25,000 cases of the disease.
UPDATE: Courtney has tested negative and is planning to donate convalescent plasma in the hope it might help others with the disease.
Leslie Newell Peacock has worked for the Arkansas Times since its switch from a monthly magazine to a weekly in 1992. She previously worked for the Arkansas Gazette. She can be reached by email: lesliepeacock@arktimes.com
Previous article Arkansas coronavirus cases top 3,000, with 50 deaths. Elective surgery may resume today, with conditions. Next article A question of priorities: Health vs. the economy
Ashleah Courtney


text:
Peli E, Bowers AR, Keeney K, Jung J-H. High-Power Prismatic Devices for Oblique Peripheral Prisms. Optom Vis Sci 2016;93(5):521-33.Abstract
PURPOSE: Horizontal peripheral prisms for hemianopia provide field expansion above and below the horizontal meridian; however, there is a vertical gap leaving the central area (important for driving) without expansion. In the oblique design, tilting the bases of both prism segments toward the horizontal meridian moves the field expansion area vertically and centrally (closing the central gap) while the prisms remain in the peripheral location. However, tilting the prisms results also in a reduction of the lateral field expansion. Higher prism powers are needed to counter this effect. METHODS: We developed, implemented, and tested a series of designs aimed at increasing the prism power to reduce the central gap while maintaining wide lateral expansion. The designs included inserting the peripheral prisms into carrier lenses that included yoked prism in the opposite direction, combination of two Fresnel segments attached at the base and angled to each other (bi-part prisms), and creating Fresnel prism-like segments from nonparallel periscopic mirror pairs (reflective prisms). RESULTS: A modest increase in lateral power was achieved with yoked-prism carriers. Bi-part combination of 36Δ Fresnel segments provided high power with some reduction in image quality. Fresnel reflective prism segments have potential for high power with superior optical quality but may be limited in field extent or by interruptions of the expanded field. Extended apical scotomas, even with unilateral fitting, may limit the utility of very high power prisms. The high-power bi-part and reflective prisms enable a wider effective eye scanning range (more than 15 degrees) into the blind hemifield. CONCLUSIONS: Conventional prisms of powers higher than the available 57Δ are limited by the binocular impact of a wider apical scotoma and a reduced effective eye scanning range to the blind side. The various designs that we developed may overcome these limitations and find use in various other field expansion applications.
Penman A, Hancock H, Papavasileiou E, James M, Idowu O, Riche DM, Fernandez M, Brauner S, Smith SO, Hoadley S, Richardson C, Vazquez V, Chi C, Andreoli C, Husain D, Chen CJ, Sobrin L. Risk Factors for Proliferative Diabetic Retinopathy in African Americans with Type 2 Diabetes. Ophthalmic Epidemiol 2016;23(2):88-93.Abstract
PURPOSE: To assess personal and demographic risk factors for proliferative diabetic retinopathy in African Americans with type 2 diabetes. METHODS: In this prospective, non-interventional, cross-sectional case-control study, 380 African Americans with type 2 diabetes were enrolled. Participants were recruited prospectively and had to have either: (1) absence of diabetic retinopathy after ≥10 years of type 2 diabetes, or (2) presence of proliferative diabetic retinopathy when enrolled. Dilated, 7-field fundus photographs were graded using the Early Treatment Diabetic Retinopathy Study scale. Covariates including hemoglobin A1C (HbA1C), blood pressure, height, weight and waist circumference were collected prospectively. Multivariate regression models adjusted for age, sex and site were constructed to assess associations between risk factors and proliferative diabetic retinopathy. RESULTS: Proliferative diabetic retinopathy was associated with longer duration of diabetes (odds ratio, OR, 1.62, p < 0.001), higher systolic blood pressure (OR 1.65, p < 0.001) and insulin use (OR 6.65, p < 0.001) in the multivariate regression analysis. HbA1C was associated with proliferative diabetic retinopathy in the univariate analysis (OR 1.31, p = 0.002) but was no longer significant in the multivariate analysis. CONCLUSIONS: In this case-control study of African Americans with type 2 diabetes, duration of diabetes, systolic hypertension and insulin use were strong risk factors for the development of proliferative diabetic retinopathy. Interestingly, HbA1C did not confer additional risk in this cohort.
Pennock S, Kim LA, Kazlauskas A. Vascular Endothelial Cell Growth Factor A Acts via Platelet-Derived Growth Factor Receptor α To Promote Viability of Cells Enduring Hypoxia. Mol Cell Biol 2016;36(18):2314-27.Abstract
Vascular endothelial cell growth factor A (VEGF) is a biologically and therapeutically important growth factor because it promotes angiogenesis in response to hypoxia, which underlies a wide variety of both physiological and pathological settings. We report here that both VEGF receptor 2 (VEGFR2)-positive and -negative cells depended on VEGF to endure hypoxia. VEGF enhanced the viability of platelet-derived growth factor receptor α (PDGFRα)-positive and VEGFR2-negative cells by enabling indirect activation of PDGFRα, thereby reducing the level of p53. We conclude that the breadth of VEGF's influence extends beyond VEGFR-positive cells and propose a plausible mechanistic explanation of this phenomenon.
Primo V, Graham M, Bigger-Allen AA, Chick JM, Ospina C, Quiroz YT, Manent J, Gygi SP, Lopera F, D'Amore PA, Arboleda-Velasquez JF. Blood biomarkers in a mouse model of CADASIL. Brain Res 2016;1644:118-26.Abstract
Mutations in NOTCH 3 are the cause of cerebral autosomal dominant arteriopathy with subcortical infarcts and leukoencephalopathy (CADASIL), a neurological disorder characterized by stroke, and vascular cognitive impairment and dementia. Loss of vascular smooth muscle cells (VSMC) and accumulation of granular osmiophilic material (GOM) deposits are hallmarks of CADASIL. There are no therapies for CADASIL and experimental endpoints to examine the preclinical efficacy of potential drugs are lacking. This study aims to use a mouse carrying the C455R mutation in Notch 3 to identify biomarkers associated with CADASIL. Mass spectrometry and antibody arrays were used to explore the aorta and blood proteomes of CADASIL mice, ELISA assays were utilized for biomarker validation, a ligand-dependent assay was applied to examine the relationship between Notch signaling and biomarker expression, and retinal histology was performed for quantification of VSMC loss in arteries. Two-hundred day-old mice with the C455R CADASIL mutation in Notch 3 mice display robust VSMC loss in retinal arteries and had increased plasma levels of collagen18α1/endostatin (col18α1) and high-temperature requirement A serine peptidase 1 (HTRA1) and reduced levels of Notch 3 extracellular domain (N3ECD), compared to control wild type mice. Measurements of plasma endostatin, HTRA1 and N3ECD, along with VSMC quantification in retinal arteries, may serve as surrogate endpoints for assessing efficacy in preclinical therapeutic studies of CADASIL using mice.
Qazi Y, Hurwitz S, Khan S, Jurkunas UV, Dana R, Hamrah P. Validity and Reliability of a Novel Ocular Pain Assessment Survey (OPAS) in Quantifying and Monitoring Corneal and Ocular Surface Pain. Ophthalmology 2016;123(7):1458-68.Abstract
PURPOSE: To validate the Ocular Pain Assessment Survey (OPAS), specifically designed to measure ocular pain and quality of life for use by eye care practitioners and researchers. DESIGN: A single-center cohort study was conducted among patients with and without corneal and ocular surface pain at initial and follow-up visits over a 6-month period. The content of the OPAS was guided by literature review, a body of experts, and incorporating conceptual frameworks from existing pain questionnaires. The Wong-Baker FACES Pain Rating Scale served as the gold standard for measuring the intensity of ocular pain. PARTICIPANTS: A total of 102 patients aged 18 to 80 years completed the OPAS at the initial visit. A total of 21 patients were followed up after treatment. METHODS: Indices of validity and internal consistency (Spearman's rank-order, rs, or Pearson's correlation coefficients, rp), and coefficient of reliability (Cronbach's α) were determined in addition to equivalence testing, exploratory factor analysis (EFA), and diagnostic analysis. MAIN OUTCOME MEASURES: Eye pain intensity was the primary outcome measure, and interference with quality of life (QoL), aggravating factors, associated factors, associated non-eye pain intensity, and self-reported symptomatic relief were the secondary outcome measures. RESULTS: The OPAS had criterion validity at both initial (rs = 0.71; n = 102; P < 0.01) and follow-up visits (rs = 0.97; n = 21; P < 0.01). Equivalence tests yielded OPAS and gold standard equivalence for both the initial and follow-up visits. The EFA supported 6 subscales (eye pain intensity at 24 hours and 2 weeks, non-eye pain intensity, QoL, aggravating factors, and associated factors) confirming multidimensionality. Cronbach's α >0.83 for all subscales established strong internal consistency, which correlated with the gold standard, including 24-hour eye pain intensity and QoL interference scores (rp = 0.81, 0.64, respectively P < 0.001). At follow-up, reduction in pain scores was accompanied by improvement in all dimensions of the OPAS. Percentage change in QoL correlated to percentage change in the gold standard (rp = 0.53; P < 0.05). The OPAS was sensitive (94%), specific (81%), and accurate (91%), with a diagnostic odds ratio >50. CONCLUSIONS: The OPAS is a valid, reliable, and responsive tool with strong psychometric and diagnostic properties in the multidimensional quantification of corneal and ocular surface pain intensity, and QoL.
Queisi MM, Zein M, Lamba N, Meese H, Foster CS. Update on ocular cicatricial pemphigoid and emerging treatments. Surv Ophthalmol 2016;61(3):314-7.Abstract
Mucous membrane pemphigoid is a systemic disorder that primarily affects mucous membranes. When localized to the conjunctiva, it is known as ocular cicatricial pemphigoid, a potentially blinding disease. Ocular cicatricial pemphigoid is an indication for systemic immunosuppressive treatment to achieve adequate remission. Immunosuppressive agents are selected with a "stepladder" approach, commencing with medications having the fewest side effects. We provide an update of the literature on immunomodulatory agents since 2011 as additional treatment modalities have been explored in the last 4 years.
Rai R, Yoon MK, Stacy RC. Tick Infestation of the Eyelid With Histopathologic Characterization. Ophthal Plast Reconstr Surg 2016;32(3):e55-8.Abstract
Ocular tick infestation is a rare occurrence. The authors report a case that is unique for being the first published example from New England, for its chronic presentation, and for the inclusion of histopathologic analysis in its diagnostic workup. A 75-year-old man was evaluated for a persistent eyelid growth secondary to an incompletely removed tick that had attached 6 months earlier. The lesion was completely excised, and a partially destroyed arthropod was observed embedded within the tissue. Light microscopy demonstrated a mixed granulomatous reaction. Given the disruption of the tick's anatomy, speciation could not be performed. The patient had an uneventful recovery. A corresponding review of tick bites to the eye is provided.
Rajagopal M, Martin MJ, Santiago M, Lee W, Kos VN, Meredith T, Gilmore MS, Walker S. Multidrug Intrinsic Resistance Factors in Staphylococcus aureus Identified by Profiling Fitness within High-Diversity Transposon Libraries. MBio 2016;7(4)Abstract
UNLABELLED: Staphylococcus aureus is a leading cause of life-threatening infections worldwide. The MIC of an antibiotic against S. aureus, as well as other microbes, is determined by the affinity of the antibiotic for its target in addition to a complex interplay of many other cellular factors. Identifying nontarget factors impacting resistance to multiple antibiotics could inform the design of new compounds and lead to more-effective antimicrobial strategies. We examined large collections of transposon insertion mutants in S. aureus using transposon sequencing (Tn-Seq) to detect transposon mutants with reduced fitness in the presence of six clinically important antibiotics-ciprofloxacin, daptomycin, gentamicin, linezolid, oxacillin, and vancomycin. This approach allowed us to assess the relative fitness of many mutants simultaneously within these libraries. We identified pathways/genes previously known to be involved in resistance to individual antibiotics, including graRS and vraFG (graRS/vraFG), mprF, and fmtA, validating the approach, and found several to be important across multiple classes of antibiotics. We also identified two new, previously uncharacterized genes, SAOUHSC_01025 and SAOUHSC_01050, encoding polytopic membrane proteins, as important in limiting the effectiveness of multiple antibiotics. Machine learning identified similarities in the fitness profiles of graXRS/vraFG, SAOUHSC_01025, and SAOUHSC_01050 mutants upon antibiotic treatment, connecting these genes of unknown function to modulation of crucial cell envelope properties. Therapeutic strategies that combine a known antibiotic with a compound that targets these or other intrinsic resistance factors may be of value for enhancing the activity of existing antibiotics for treating otherwise-resistant S. aureus strains. IMPORTANCE: Bacterial resistance to every major class of antibiotics has emerged, and we are entering a "post-antibiotic era" where relatively minor infections can lead to serious complications or even death. The utility of an antibiotic for a specific pathogen is limited by both intrinsic and acquired factors. Identifying the repertoire of intrinsic resistance factors of an antibiotic for Staphylococcus aureus, a leading cause of community- and hospital-acquired infections, would inform the design of new drugs as well as the identification of compounds that enhance the activity of existing drugs. To identify factors that limit the activity of antibiotics against S. aureus, we used Tn-Seq to simultaneously assess fitness of transposon mutants in every nonessential gene in the presence of six clinically important antibiotics. This work provides an efficient approach for identifying promising targets for drugs that can enhance susceptibility or restore sensitivity to existing antibiotics.
Ramachandran P, Lee V, Wei Z, Song JY, Casal G, Cronin T, Willett K, Huckfeldt R, Morgan JIW, Aleman TS, Maguire AM, Bennett J. Evaluation of dose and safety of AAV7m8 and AAV8BP2 in the non-human primate retina. Hum Gene Ther 2016;Abstract
Within the next decade, we will see many gene therapy clinical trials for eye diseases progress, which may lead to treatments for thousands of visually impaired people around the world. To target retinal diseases that affect specific cell types, several recombinant adeno-associated virus (AAV) serotypes have been generated and used successfully in pre-clinical mouse studies. Because there are numerous anatomic, and physiologic differences between the eyes of mice and 'men' and because surgical delivery approaches and immunologic responses also differ between these species, we evaluated the transduction characteristics of two promising new serotypes AAV7m8 and AAV8BP2, in retinas of animals that are most similar to those of humans: non-human primates (NHPs). We report that while AAV7m8 efficiently targets a variety of cell types by subretinal injection in NHPs, transduction after intravitreal delivery was mostly restricted to the inner retina at lower doses that did not induce an immune response. AAV8BP2 targets the cone photoreceptors efficiently but bipolar cells inefficiently by subretinal injection. Additionally, we observed transduction of both serotypes in the anterior chamber of the eye and the optic pathway of the brain post intravitreal delivery. Finally, we assessed immunogenicity, keeping in mind that these AAV capsids may be used in future clinical trials. We found that AAV8BP2 had a better safety profile compared to AAV7m8 even at the highest doses administered. Our studies underscore the differences in AAV transduction between mice and primates highlighting the importance of careful evaluation of therapeutic vectors in NHPs prior to moving into clinical trials.
Rameh LE, Mackey AM. IQGAP1 makes PI(3)K signalling as easy as PIP, PIP2, PIP3. Nat Cell Biol 2016;18(12):1263-1265.Abstract
Despite being one of the most studied signalling pathways, precisely how phospholipid synthesis is regulated in the phosphoinositide signalling cascade remains unclear. The scaffold protein IQGAP1 is now shown to orchestrate the assembly of a multi-enzyme complex that streamlines PtdIns(3,4,5)P3 synthesis to facilitate Akt activation in response to extracellular stimuli.
Ramke M, Zhou X, Materne EC, Rajaiya J, Chodosh J. Resident corneal c-fms(+) macrophages and dendritic cells mediate early cellular infiltration in adenovirus keratitis. Exp Eye Res 2016;147:144-7.Abstract
The cornea contains a heterogeneous population of antigen-presenting cells with the capacity to contribute to immune responses. Adenovirus keratitis is a severe corneal infection with acute and chronic phases. The role of resident corneal antigen-presenting cells in adenovirus keratitis has not been studied. We utilized transgenic MaFIA mice in which c-fms expressing macrophages and dendritic cells can be induced to undergo apoptosis, in a mouse model of adenovirus keratitis. Clinical keratitis and recruitment of myeloperoxidase and CD45(+) cells were diminished in c-fms depleted, adenovirus infected mice, as compared to controls, consistent with a role for myeloid-lineage cells in adenovirus keratitis.
Rapoport Y, Singer JM, Ling JD, Gregory A, Kohanim S. A Comprehensive Review of Sex Disparities in Symptoms, Pathophysiology, and Epidemiology of Dry Eye Syndrome. Semin Ophthalmol 2016;Abstract
INTRODUCTION: The etiology, frequency, manifestation, and treatment of dry eye syndrome are commonly influenced by sex and gender. MATERIALS AND METHODS: This study aims to review the differences in epidemiology, pathophysiology, and associated diseases between the sexes. The terms men and male and women and female are used interchangeably throughout the review to refer to biological sex. RESULTS: There are numerous objective and subjective markers of dry eye syndrome but not one diagnostic criterion. There are numerous associated conditions with dry eye syndrome varying from autoimmune to allergic. Large epidemiologic studies reviewed suggest that there does indeed exist a difference between dry eye symptoms between men and women, with women having dry eye signs and reporting dry eye symptoms more often than men. The increased prevalence in women could be correlated to an increased association with certain systemic diseases, specifically autoimmune diseases, and to hormonal variations. Several studies found equivocal data about prevalence of dry eye symptoms between men and women. DISCUSSION: Interpreting studies that investigate epidemiology, pathogenesis, and treatment of dry-eye conditions is complicated by the lack of universally adapted diagnostic criteria and standardized, specific diagnostic tests, and inter-study variability in the definition of dry eye syndrome.
Reddy DN, Yonekawa Y, Thomas BJ, Nudleman ED, Williams GA. Long-term surgical outcomes of retinal detachment in patients with Stickler syndrome. Clin Ophthalmol 2016;10:1531-4.Abstract
PURPOSE: The aim of the study was to present the long-term anatomical and visual outcomes of retinal detachment repair in patients with Stickler syndrome. PATIENTS AND METHODS: This study is a retrospective, interventional, consecutive case series of patients with Stickler syndrome undergoing retinal reattachment surgery from 2009 to 2014 at the Associated Retinal Consultants, William Beaumont Hospital. RESULTS: Sixteen eyes from 13 patients were identified. Patients underwent a mean of 3.1 surgical interventions (range: 1-13) with a mean postoperative follow-up of 94 months (range: 5-313 months). Twelve eyes (75%) developed proliferative vitreoretinopathy. Retinal reattachment was achieved in 100% of eyes, with ten eyes (63%) requiring silicone oil tamponade at final follow-up. Mean preoperative visual acuity (VA) was 20/914, which improved to 20/796 at final follow-up (P=0.81). There was a significant correlation between presenting and final VA (P<0.001), and patients with poorer presenting VA were more likely to require silicone oil tamponade at final follow-up (P=0.04). CONCLUSION: Repair of retinal detachment in patients with Stickler syndrome often requires multiple surgeries, and visual outcomes are variable. Presenting VA is significantly predictive of long-term VA outcomes.
Robert M-C, Arafat SN, Spurr-Michaud S, Chodosh J, Dohlman CH, Gipson IK. Tear Matrix Metalloproteinases and Myeloperoxidase Levels in Patients With Boston Keratoprosthesis Type I. Cornea 2016;35(7):1008-14.Abstract
PURPOSE: To investigate the tear levels of matrix metalloproteinases (MMPs), myeloperoxidase (MPO), and tissue inhibitor of metalloproteinase-1 in eyes after Boston keratoprosthesis type I (B-KPro) implantation and to correlate these markers with the established B-KPro prognostic categories. METHODS: Tear washes were collected from 40 patients (7 with autoimmune disease, 2 with chemical burn, and 31 with other noncicatrizing diagnoses). Tear levels of MMPs, MPO, and tissue inhibitor of metalloproteinase-1 were quantified using multianalyte bead-based enzyme-linked immunosorbent assays. The total MMP activity was determined using a fluorimetric assay. The analytes were compared to the underlying diagnosis and other clinical factors. RESULTS: The MMP-8, MMP-9, and MPO levels were markedly elevated in the eyes with B-KPro (80 ± 31, 291 ± 77, and 244 ± 33 pg/μg, respectively). Chemical burn was associated with significantly higher tear MMP-8 (474 ± 376 pg/μg) and MMP-9 levels (1300 ± 635 pg/μg) compared with noncicatrizing diseases (MMP-8: 41 ± 15 pg/μg, P = 0.02 and MMP-9: 196 ± 57 pg/μg, P = 0.02) and higher MMP-9 levels compared with autoimmune diseases (MMP-8: 96 ± 65 pg/μg, P = 0.21 and MMP-9: 306 ± 196 pg/μg, P = 0.04). Similar analyte levels were observed in the B-KPro eye and the contralateral non-B-KPro eye of patients with bilateral diseases. MMP-8, MMP-9, and total MMP activities correlated strongly with each other. CONCLUSIONS: In the eyes with B-KPro, tear MMP-8 and MMP-9 levels seem to be related to the underlying ocular surface pathology and not significantly influenced by the presence of the prosthesis.
Robert M-C, Frenette M, Zhou C, Yan Y, Chodosh J, Jakobiec FA, Stagner AM, Vavvas D, Dohlman CH, Paschalis EI. A Drug Delivery System for Administration of Anti-TNF-α Antibody. Transl Vis Sci Technol 2016;5(2):11.Abstract
PURPOSE: To describe the fabrication, evaluation, and preliminary in vivo safety of a new drug delivery system (DDS) for topical anti-TNF-α antibody administration. METHODS: A DDS was fabricated using inverse template fabrication of a hydrophobic three-dimensional porous scaffold (100-300 μm in diameter porosity) loaded with 10% polyvinyl alcohol hydrogel carrying 5 mg/ml (weight/volume) of anti-TNF-α antibody. Drug-loaded DDS was sterilized with 25 kGy of gamma irradiation. Long-term in vitro antibody affinity and release was evaluated at room temperature or 37°C using enzyme-linked immunosorbent assay (ELISA) and protein fluorescence. In vivo clinical and histolopathological assessment was performed by subcutaneous implantation in BALB/c mice for 3 months. RESULTS: Gamma irradiation, repeated dry/wet cycles, and storage at room temperature for 1 year or 37°C for 1 month had no deleterious effects on antibody affinity. Anti-TNF-α release was high during the first minutes of aqueous exposure, followed by stabilization and gradual, low-dose, antibody release over the next 30 days. Histopathologic evaluation of explanted DDS showed a fibrous pseudocapsule and a myxoid acute/chronic inflammation without granuloma formation surrounding the implants. CONCLUSIONS: Sustained local delivery of anti-TNF-α antibody is feasible using the described DDS, which provides stability of the enclosed antibody for up to 1 year of storage. Preliminary results show good in vivo tolerance following subcutaneous placement for 3 months. The proposed fabrication and sterilization process opens new possibilities for the delivery of biologic agents to the anterior surface of the eye. TRANSLATIONAL RELEVANCE: The described DDS will facilitate the treatment of ocular surface diseases amenable to biologic therapy.
Robert M-C, Črnej A, Shen LQ, Papaliodis GN, Dana R, Foster SC, Chodosh J, Dohlman CH. Infliximab after Boston Keratoprosthesis in Stevens-Johnson Syndrome: An Update. Ocul Immunol Inflamm 2016;:1-5.Abstract
PURPOSE: To report our experience using intravenous infliximab for the treatment of tissue melt after Boston keratoprosthesis (B-KPro) types I and II in patients with autoimmune disease. METHODS: Case series. RESULTS: We identified four patients who were treated with intravenous infliximab in the context of tissue melt after B-KPro. Stevens-Johnson syndrome-associated corneal blindness was the primary surgical indication for B-KPro implantation in all patients. Two patients received a B-KPro type I and two patients received a B-KPro type II. The patients received intravenous infliximab for skin retraction around B-KPro type II, melting of the carrier graft or leak. Treatment resulted in a dramatic decrease in inflammation and, in some cases, arrest of the melting process. Cost and patient adherence were limiting factors to pursuing infliximab therapy. In addition, one patient developed infusion reactions. CONCLUSIONS: Intravenous infliximab may be considered as globe- and sight-saving therapy for tissue melt after B-KPro.
Rodriguez JD, Lane KJ, Ousler GW, Angjeli E, Smith LM, Bateman KM, Abelson MB. Diurnal Tracking of Blink and Relationship to Signs and Symptoms of Dry Eye. Cornea 2016;35(8):1104-11.Abstract
PURPOSE: To assess diurnal changes in the signs and symptoms of dry eyes and their relationship to diurnal interblink interval (IBI) in normal subjects and in subjects with dry eye. METHODS: Blink data were collected from 9:00 AM to 8:00 PM during 2 days of normal activity using an electrocardiogram monitoring device. All subjects recorded ocular discomfort (0-5 scale) and primary activity hourly each day in a diary. Inferior and central fluorescein staining was graded by slit lamp (0-4) at the start and end of each day. Blink activity was detected using an algorithm based on recognition of the waveform corresponding to the kinematic properties of the blink signal. RESULTS: Normal subjects (N = 12) reported negligible symptoms, and results did not show a diurnal change in group hourly IBI. Mean daily IBI for the group with dry eye (N = 15) (4.63 ± 1.63 s) was shorter than that for the normal group (5.28 ± 1.48 s) (P = 0.0483). Correlation of diurnal symptoms and mean hourly IBI was relatively weak (r = -0.248). A repeated-measures model found IBI to be significantly associated with the time of day (P = 0.0028). Inferior corneal staining showed a small but significant diurnal increase for both normal group and group with dry eyes. CONCLUSIONS: Diurnal blink tracking reveals significant trending with symptoms. Diurnal change in IBI may be an appropriate surrogate for symptoms in the study of dry eye.
Roh M, Yasa C, Cho H, Nicholson L, Uchiyama E, Young LHY, Lobo A-M, Papaliodis GN, Durand ML, Sobrin L. The role of serological titres in the diagnosis of ocular toxoplasmosis. Acta Ophthalmol 2016;94(5):521-2.
Roohipoor R, Karkhaneh R, Farahani A, Ebrahimiadib N, Modjtahedi B, Fotouhi A, Yaseri M, Khodabande A, Zarei M, Imani Fuladi M, Taheri A, Riazi Esfahani M, Loewenstein J. Retinopathy of prematurity screening criteria in Iran: new screening guidelines. Arch Dis Child Fetal Neonatal Ed 2016;101(4):F288-93.Abstract
OBJECTIVE: To test the applicability of existing retinopathy of prematurity (ROP) guidelines on Iranian patients and to develop novel ROP screening criteria in Iran. METHODS: Both eyes of 1932 infants born ≤37 weeks of gestation and/or weighting ≤3000 g were included in this prospective cohort study that was conducted across nine neonatal intensive care units and a tertiary eye hospital ROP clinic. The patients were examined for ROP and the need for treatment (type 1 ROP or worse). All the patients were screened 4 weeks after birth or at 31 weeks of postmenstrual age, whichever was later. The patients were followed until retinal vascularisation was completed or the patients reached 50 weeks of gestational age (GA) without prethreshold ROP. A receiver operating characteristic curve was used to determine the best screening criteria for ROP. Screening criteria from other countries were applied to our patient data to determine their ability to appropriately detect ROP. MAIN OUTCOME MEASURE: Patients with ROP requiring treatment. RESULTS: The mean GA±SD and birth weight (BW)±SD of the screened patients were 32±2.7 weeks and 1713±516 g, respectively. Using criteria of GA≤32 weeks or BW ≤2000 yielded sensitivity and specificity of 100% and 26.7%, respectively, for treatment requiring ROP regardless of clinical comorbidities. Using screening recommendations of American Academy of Pediatrics would miss 25.4% of ROP and 8.4%ROP requiring treatment in our cohort. CONCLUSIONS: Other countries screening recommendations would result in a significant amount of missed cases of treatment requiring ROP when applied to Iran. As a result, we have proposed new guidelines for premature babies in Iran.
Rosenvald OR, Lessell S. Pupillary sign of aberrant regeneration of the third nerve. Neurology 2016;86(18):1746.


The Snipping tool is a great alternative to paid screen capturing software out there. It allows users to select different modes of capture (full screen vs. rectangle), it provides some primitive editing tools (a pen with multiple colors, an eraser, and a highlighter). I can see this as a great tool for tablet users. It doesn't have all the bells and whistles of paid screen capture tools, but it certainly gets the job done. The guide below will show you how to use the program to make a screen capture and save it. If you have any questions or comments, feel free to post them below.
1. Click the Start Menu button (the Orb) and locate the Snipping Tool program, click to open.
2. The Snipping Tool window will open. To capture a screen shot, click on the New button and select Rectangular Snip from the menu.
Free-form Snip: A free-form snip, the name says it all.
3. Click and drag (while holding down the left mouse key) a rectangle around the area you wish to capture. The red lines indicate the boundaries of the current capture. When you're happy with your selection release the left mouse key to finalize your selection.
4. Your selection should now appear in the Snipping Tool window. Here you can edit the image by adding notes, highlighting, and erasing.
5. To save your screen capture, click on the Floppy button located on the menu bar.
6. Locate the directory you wish to save the screen capture to and click Open to access the folder.
7. Name your screen capture and click Save to save the image to your desired location.