All Grins and Pitter were busy for a couple of days with the negotiations. The rest of us were not needed.
But when they were done, we all took off into the mountains. It was cold, really cold. So I had Kord protect us from the elements and we managed to make it through the mountains. We fought a few critters along the way, but nothing to shocking.
According to the map, the smith was located halfway up this one mountain. So we trudged up the mountain and found a cave. Exploring it, All Grins spotted a hidden door. Past the door was a tunnel that led to a rather nice cavern. It was filled with stuff, but it seemed abandoned.
We looked around and I was unsure whether we were missing anything. So I asked Kord to reveal that which was not visible. And there, in the corner, was a dwarf. He eyed me darkly.
"Ah, so a follower of Kord, you be. Will I never get some peace?"
"I am Mord, I serve Kord with my greatsword." The others looked pained.
"Great and noble dwarf, we have come to seek your assistance," said Throw Down. He was always such a good talker."Smitmar, I presume?"
"Who are you and what do you want? I have not seen others in many years and that is for a reason."
"Master Smitmar, I was a student of Core Rid It, and he died. He left a note saying to come here."
"Core, ah Core. He had such promise. Such wasted promise. Dead, you say? That is surprising. Tell me what happened."
And so we talked. Smitmar was willing to help us. He actually had quite the setup for a smith which was a little odd since he was in the middle of nowhere. His eyes kept looking at me with the oddest look in them.
"Giant troubles? Well, it sounds like the time for the Hammer of Thunderbolts has returned. Look, you get the Hammer for me and I will make your weapons more powerful if you like. Right? Good. So, all you need to do is go to Ysgard and find the Hammer. Then come back. You can get to Ysgard, can't you?"
"Master Smitmar, I do not have a fork to Ysgard. But otherwise, yes, we can go. Ysgard, wow. Amazing. Yes, we will do this. Or die trying."
"Oh, you will die, no question about that. Many times, I presume. Look, leave your stuff here otherwise you are likely to lose it. You can have some of those rusty weapons over there. Here is what I know about where to find the Hammer..."
And so it was that we travel to Ysgard.
Barrel asked me about Ysgard, what I knew about it.
"Yes, I know. What else do you know? Did you not study planes at the temple?"
"I studied planes for years."
"So what else do you know."
"Wait, you are actually saying it correctly."
"Yeah, that took me years. I proud. Oh, and I do remember that this is a place with lots of dying. Big battles, everyone dies, painfully. But they come back the next day for drinking, merriment, and killing. My kind of place."
"Very. I can't wait for Smitmar to find his fork."
And so after a day of searching, Smitmar gave me his fork. He is going to work on our weapons while we explore Ysgard. Tomorrow promises to be very exciting.
Mords of Wisdom: Hermits should live somewhere nice.


You are here: Information > Wirral's Wonderful Waders!
The third Wirral Wader Festival will take place this September to celebrate the tens of thousands of wading birds that visit Wirral's unique coastline every year.
Wading birds such as knots, dunlins, curlews and bar-tailed godwits feast on the rich mudflats of the Dee estuary and North Wirral shores and can be easily seen from places such as Hoylake promenade.
To showcase this natural spectacle, Wirral Coast Partnership has organised a busy programme of events for Wirral Wader Festival on the 8th, 9th and 10th September.
Karen Leeming, Chair of the Wirral Coast Partnership commented that: "Since the Wirral Wader Festival Partnership held the first UK Wader Festival in 2015, it has encouraged a number of other UK coastal areas to follow suit and we think that this is a fantastic achievement.
"The entire Wirral coastline has protection as a Site of Special Scientific Interest for the internationally important numbers of wading birds that live here through autumn and winter. As a result, it is the focus of conservation efforts from a number of environmental organisations, local authority departments and private sector organisations who all contribute to the event.
"The Festival starts with a talk by the naturalist and environmentalist Iolo Williams, also a renowned presenter on the BBC's Springwatch and Autumnwatch, on Friday evening and then a full weekend of events held at Hoylake and West Kirby.
Wirral was approached to hold the first event of its kind in the UK in 2015 by Rick and Elis Simpson of Wader Quest. They came on a visit to view the remarkable efforts of the Dee Estuary Voluntary Wardens (DEVW) who protect the thousands of birds roosting on West Kirby and Hoylake beaches at high tide.
Wirral Wader Festival was created by DEVW with Wirral Council's Coastal Rangers, Cheshire Wildlife Trust, the RSPB and Wader Quest.
There will be high tide watches to marvel at the knot and dunlin roosts on Hoylake beach and at Cheshire Wildlife Trust's Red Rocks nature reserve. At West Kirby there will be live footage beamed direct from Little Eye, showing off the oystercatchers and curlews up close.
Cheshire Wildlife Trust will be holding guided walks around the Red Rocks SSSI nature reserve and hosting the children's activities. Wirral Rangers will be guiding a walk to Hilbre Island.


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In Revenge Game, Soul Trounce Rival Gladiators
Cleveland Gladiators Insider Post Philadelphia Soul post-game story
Ben Heck
Philadelphia — In a key matchup between two bitter division rivals, the Philadelphia Soul continued their scorching offensive start to remain undefeated this season, defeating the Cleveland Gladiators 63-48 on Saturday night at the Wells Fargo Center.
"In the second half, we played the way I was looking for," head coach Clint Dolezel said about tonight's performance. "It kind of worked out in the first half… we were kind of scrapping around and hanging in there."
Philadelphia's red-hot offense continued with another sensational effort tonight. Led by quarterback Dan Raudabaugh who threw for 262 yards and 7 touchdowns, earning another Russell Offensive Player of the Game, scored on all nine of their possessions tonight.
"That's the goal in this game. As an offense, all we ask for our defense is to get us one stop," Raudabaugh said.
Marco Thomas, known for having the best hands in Arena Football, hauled in a deep one-handed touchdown catch — one that you should certainly see on Sportscenter's top ten — on the Soul's opening possession of the second half, staking Philadelphia to a comfortable second half lead. Thomas finished the game with nine catches for 108 yards and three touchdowns.
"I just come out here and do my job," Thomas said of his performance. "I just want to be a good teammate… whatever I can do to help the team come out with a victory."
Cleveland managed to trim their 22-point deficit down to eight midway through the third quarter after Gladiators quarterback Shane Austin connected with wide receiver Collin Taylor for two consecutive touchdowns but failed to get any closer. Taylor finished the game with 10 catches for 120 yards and four touchdowns, including an impressive touchdown grab in double coverage.
Soul receiver Ryan McDaniel — who has been Raudabaugh's go-to-guy this season — quietly had himself a good game, overshadowed by the play of his teammate Thomas. In addition to his 7 catches for 73 yards and three touchdowns, McDaniel made some huge catches to extend drives and even ran the ball for a touchdown.
Philadelphia a year ago was swept in the season series by the Gladiators, including being eliminated on a late field goal in the first round of the playoffs. Although many believed that this was certainly a revenge game for the Soul, coach Dolezel doesn't think so.
"Over half these guys weren't here last year, so were not focused on that [revenge]," he said. "like [Taggart] said, it's not about them, its about us."
Philadelphia remains perfect (4-0) in the early stages of the 2015 season and have look very impressive doing it. After a perfect 2-0 home stand, the Soul will hit the road next week to take on a struggling New Orleans Voodoo (1-3).
Soul's Defensive Effort Leads To 10-0 After Win Over Cleveland
Storm Clinch Playoff Berth after Win over Valor
Soul Score Season High 83 points; Win Final Home Game Of Season Against Cleveland
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redpajama_set_name: RedPajamaCommonCrawl


Mix the chickpeas, celery and strawberries. Add the oil, lime zest and lime juice, mix and season.
Place the fish fillets on the work surface, drizzle with lemon juice, season. Arrange approx. 4 basil leaves on top of each fillet, roll up and secure with toothpicks.
Heat the oil in a large non-stick frying pan, reduce the heat. Fry the fish parcels for approx. 1 1/2 mins. on each side, serve with the salad.


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People's United Democratic Movement er det største oppositionsparti i Swaziland. Partiet blev dannet den 7. juli 1983. Partiet ledes af demokratiaktivist Mario Masuku. Alle politiske partier, inklusive PUDEMO, er forbudte i Swaziland, der er et enevældigt monarki.

Referencer

Eksterne henvisninger
 PUDEMOs hjemmeside
 PUDEMO udtalelse fra NEC meeting 2010
 Frit Swaziland på Afrika.dk
 Mario Masuku-biografi
 Mario Masuku modtager Demokrati-pris

Politiske partier i Swaziland
Etableret i 1983

redpajama_set_name: RedPajamaWikipedia


Cook pasta to desired doneness as directed on package; drain.
Heat oven to 350ºF. Spray 2 quart casserole with nonstick cooking spray.
In large bowl, combine cooked pasta, chicken, celery, onion, basil and pepper; mix well.
In medium bowl, combine mayo, milk and sour cream (and ranch dressing mix); blend well. Add to pasta mixture and mix well.
Spoon mixture into sprayed casserole. In small bowl, combine all topping ingredients; mix well. Sprinkle over casserole.
Bake at 350ºF for 40-45 minutes or until hot and bubbly.


Did you know that the largest knife in the world is smaller than the largest spoon in the world? Who would've ever known? There are three world records for large knives: the largest utility knife, the largest pocket knife (it doesn't fit in your pocket just as a little FYI) and the largest Bowie knife.
World's largest pocket knife (metal item) in comparison with the world's largest spoon (wooden item).
On December 21, 2010, Garima Foundation and Pankaj Ojha from Jaipur, India unveiled the largest spoon and pocket knife to a group of Guinness Book of World Records judges. Now available for sightseeing at the Pink Square Mall in Jaipur, India, the large spoon was over 3 stories long whereas the large folding knife had a handle of 111 inches long. The blade was 97 inches long.
In an attempt to get more people to its trade-show booth, Olympia Tools unveiled the world's largest utility knife, a replica of its TurboPro AutoLoader utility knife, during the National Hardware Show in Las Vegas, NV during its May 1st, 2012 event. As you can see from the photo, it is huge. It was used to display the AutoLoader's ease of replacing a blade. Yes, the blade is huge as well.
World's largest utility knife blade.
In April 2016, the town of Bowie, Texas unveiled the largest Bowie knife in the world at 3000 pounds, 20 feet long with a 14- foot, 5-inch long stainless steel blade. It went on to earn a spot in the Guinness World Book of Records. It took three years and $170,000 to complete and is a boon for tourism in the area. The name Bowie—both the town and the knife—comes from James "Jim" Bowie, who is best known for his role in the Texas Revolution and the Battle at the Alamo.
Those are the three largest knives in the world. If you enjoyed this, check out the 3 best machetes, how to buy a pink pocket knife, and top 3 Balisong knives.
The Single Best Self Defense Product You Will Own!
This is like a sale on STEROIDS!
Knifeup.com is a participant in the Amazon Services Associates Program, an affiliate advertising program designed to provide a means for us to earn fees by linking to Amazon.com and affiliated sites.
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Here at INNOBYTE, we treasure every day of the week. We come to work joyful, because our team is awesome and our projects are challenging enough.
From time to time, we have fun with internal challenges. Last Friday, was like no other Friday, because all of our team members were asked to come at work dressed in Black &White.
Do you remember our 20s outfits?


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«Прощальная симфония» () — роман Эдмунда Уайта, заключительная часть его автобиографической трилогии, продолжение новелл «История одного мальчика» и «Красивая комната пуста».

Содержание
Действие в романе охватывает временной период с 1960-х по 1990-е годы. Это история писателя-гея, который пережил большинство своих друзей, его рассказ о годах жизни в Нью-Йорке, Риме и Париже, о борьбе за выживание и стремлении к признанию. Обзор культурной жизни Манхеттена сочетается в романе с закулисными сценами секса и садомазохизма.

Аллюзии
Название романа является аллюзией на прощальную симфонию Йозефа Гайдна, при исполнении которой музыканты покидают сцену один за другим до тех пор, пока на ней не останется одна скрипка, которая продолжает играть.

Примечания

Романы 1997 года
Книги по алфавиту
Романы на английском языке
Книги на тему мужской гомосексуальности


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Inspired by nature, reusable coffee cup designs get the thumbs up
July 16, 2018 Amy Brice
Entirely plastic free and crafted from the humble rice husk, Huskup's reusable coffee cups have now become a canvas, inspiring designers to help the nation's coffee lovers to say no to single use. An instant bestseller for Huskup, the 'Thumbs Up' design caught the mood of the moment and has set the tone for a range of other patterns inspired by nature.
Frome-based designer, Donna Sarah is the creative behind these concepts, and a full range of her designs is now available from Huskup. Representing fundamental features of the natural world, from the coastline to the woodlands to the mountains, each design also leaves space for the natural material of the rice husk to shine through. These new designs, named Pebbles, Sticks and Triangles, take a simple, geometric approach, appealing to an eco-audience who want a unique product to reuse time and again.
Richard Milton, founder of Huskup, explains:
"To create a truly green product, all the pieces of the eco-jigsaw have to fit together, so choosing to work with local designers who share our environmental principles was a no brainer. Donna's designs have naturally struck a chord with reusable cup shoppers across the country, and with more design collaborations on the way, we plan to keep Huskup a desirable product that makes it easy and appealing to tackle disposable culture."
Donna Sarah, designer of the mono Huskup range, adds:
"I was very impressed by the way that Huskup uses a by-product to resolve a pressing modern-day problem and it has been a great opportunity to be one of the first designers to work with the rice husk material. The thumbs up design is a little message to represent the good that the cup is doing for the earth, while with the other designs I took the planet itself as my starting point. Each one is based on an element of nature, the ground beneath us, the water and the trees, all things we must look to protect from now on."
The Huskup comes in 12 different designs and can be purchased from www.huskup.com, priced at £10.95 each.
Free range festivities as traditional eggs triumph at Taste of the West
Carving out family time this Christmas with a truly traditional turkey


"The right to farm gmo-free and the right to eat gmo-free, that is what's at stake here," said Marc Loiselle, an organic farmer and SOD board member. Approximately 1,000 farmers in Saskatchewan grow crops organically on about 1 million acres. Another 200 farmers are transitioning to organic methods.
The plaintiffs are seeking damages "in the millions of Canadian dollars," for what they see as Monsanto's and Aventis' failure to take responsibility for transgenic contamination on multiple grounds. Those include negligence, nuisance, trespass, pollution under the Saskatchewan Environmental Management and Protection Act and failure to conduct an environmental assessment and seek ministerial approval as required by the Environmental Assessment Act of Saskatchewan. The plaintiffs will also seek an injunction to halt Monsanto from introducing Roundup Ready wheat, engineered to resist the herbicide Roundup (glyphosate).
If the action is certified as a class action by the Court under Saskatchewan's recently enacted Class Actions Act, all certified organic farmers in Saskatchewan will be represented, with the possibility that other Canadian certified organic grain farmers residing outside Saskatchewan being given the option of participating at a later date.
Terry Zakreski, legal counsel representing the plaintiffs, said that the next significant step in the process is to request that the Court certify the action as a class action under the Act, which he anticipates will take place within a few months.
Growing and certifying organic canola in Canada is nearly impossible for two reasons, said farmer and SOD president Arnold Taylor. The spread of the genetics from Roundup Ready canola since its introduction in 1996-97 has made obtaining pure seed difficult. And even if a farmer could manage to do so, cross-pollination happens easily in the field.
The loss of the canola market has hurt, but, said Loiselle, transgenic wheat would be the mortal blow not only to organic growers but all farmers.
The Canadian Wheat Board, which is responsible for all wheat and barley exports, sells wheat, durum and barley to more than 70 countries. According to the Board's website, www.cwb.ca, that translates into about 20 percent of the world market share in wheat, 65 per cent of durum wheat, 30 per cent of malting barley and 15 per cent of feed barley.
Many of those 70 countries have said they will reject Roundup Ready wheat or any wheat showing signs of transgenic contamination, said Bill Toews, a Manitoba commercial grower of wheat, canola, flax, barley and oats. If that happens, farmers could lose hundreds of millions of dollars.
The Organic Agriculture Protection Fund has raised enough money to begin the lawsuit, Loiselle and Taylor said, although they would not specify the amount raised.


It's been a while (massive understatement) since Mark and I wrote any blog posts, and I'm so sorry for that. We weren't really happy with how the blog looked and needed to change it, but just never got around to it. Now that we're happy with how it looks, I think we'll both feel more motivated to post.
About a week or so after my 22nd birthday, I was moaning to mark for the 100th time that I was really tired and just felt like crap. Mark suggest that perhaps there was a chance I was pregnant. I was adamant that wasn't the case and I was just under the weather, but just to prove a point I got a pregnancy test.
And it turns out Mark was right!! I was pregnant and we were going to be having a baby by March 2018, which was a huge shock. I couldn't believe it, Mark was surprised, but we were both very happy. I'm currently 17 weeks pregnant and we actually recently found out we're having a little boy!
So as you can see, A LOT has happened over the last few months. It's been busy, and scary but absolutely wonderful.
We will definitely try and post more and keep you updated on life and our goings on.


Through family we find ourselves as we give and receive support. Family brings out the best and worst in each of us. As we yield to and serve others we learn to love them and ourselves in the process.
Over the years, I come to learn the importance of family. I have a wonderful husband, and I'm happily married. I am the mother of two beautiful daughters. Both of them have made me proud throughout the years.
Family members near and far have made visiting a joy. And our circle of support constantly reminds me why family is important.


I recently opened up USA Today to a two-page centerfold ad by Wells Fargo that read: Established 1852, Re-Established 2018.
Shortly after that, I saw a 60-second TV ad, artfully written with high-end videography. On my drive home, I heard the message again on the radio. Everywhere I turned, Wells Fargo was trying to reassure me that they had lost their way but were working hard to get back on track.
All of this is part of a multi-million dollar campaign called Re-Established, an attempt by Wells Fargo to recoup their 166-year-old reputation rocked by bad corporate behavior and a fake accounts scandal.
The costs are much more than monetary.
The scandal has generated several federal investigations with likely more to come. It cost their CEO his job and ushered in a new Board of Directors. While Wells Fargo has settled a class-action suit, the litigation may not be over.
In response, the company has rewritten its policies, hired 2,000 new risk managers, rededicated itself to a set of corporate values that — at least on paper — put customers ahead of profitability, and apologized for and taken steps to remedy fraudulent practices.
The question is will it be enough to restore the public's trust in a once well-established, venerable brand? Only time will tell.
What can the rest of us learn — and what should we do?
An organization's reputation is its most valuable asset. It drives whether people want to shop with you, bank with you, and whether employees are proud to tell their families and friends that they work for you. When incidents do occur, the threat to eroded customer confidence, employee loyalty and the public's perception is real and costly. Organizations that take the "trust factor" seriously are organizations better prepared for the inevitability of turbulent times.
Trust goes to the core of every relationship: Our relationships with each other, with our government institutions and with the businesses we patronize. People who know you before a crisis hits will decide whether they can trust your organization again. If people don't know you before a crisis occurs, chances are the crisis will define you.
Investing in the protection and enhancement of a reputation is good business. Continually assessing where an organization needs to adjust policies and behavior going forward is a strategic investment. Smart organizations, attuned to the public's demand for transparency, continually take inventory of their own policies and practices looking for gaps and soft spots.
Incidents like the one at Wells Fargo bring additional scrutiny not only to themselves, but to others in their industry. People may ask, what are your business practices? Are there similar trends in behavior that we should worry about? Others may be asked to account for their own practices in order to reassure customers and the community that we can trust them to do the right thing.
There has never been a more pivotal time for organizations to take a hard look at whether they are doing everything they can to carefully manage their reputations. From young start-ups to a time-honored brand, a reputation is everything that matters.


text:
Q: Autocomplete (Intellisense) does not work properly for Python in VSCode I am using VSCode for Python development working in a Dev-Container. Python is installed inside the dev-container and the Python executable path in the settings.json file is correct.
However, when I import numpy via "import numpy as np" in some module I am writing and start typing "np.", the pop-up window will only display some of the methods that the numpy module offers. E.g., if I start typing "np.a", the abs-method is not displayed in the pop-up windows. In general, it seems like most of the methods are missing.
Any ideas on how to fix this issue?

redpajama_set_name: RedPajamaStackExchange


text:
Troon (gaelico scozzese: An Truthail / An t-Sròn, scots The Truin) è una città del Regno Unito, che si trova nella Scozia meridionale, precisamente a sud-ovest, nell'area dell'Ayrshire Meridionale.

Sulle rive del Firth of Clyde, la cittadina è sede di un porto sia commerciale che per traffico passeggeri.

Amministrazione

Gemellaggi

Note

Altri progetti


text:
Dead Silence (Paperback)
By S.A. Barnes
11 on hand, as of Feb 1 5:03pm
A Best Book of 2022 by the New York Public Library • One of the Best SFF Books of 2022 (Gizmodo) • One of the Best SF Mysteries of 2022 (CrimeReads) • A GoodReads Choice Award finalist for Best Science Fiction!
Titanic meets Event Horizon in this SF horror novel in which a woman and her crew board a decades-lost luxury cruiser and find the wreckage of a nightmare that hasn't yet ended.
Claire Kovalik is days away from being unemployed—made obsolete—when her beacon repair crew picks up a strange distress signal. With nothing to lose and no desire to return to Earth, Claire and her team decide to investigate.
What they find is shocking: the Aurora, a famous luxury spaceliner that vanished on its maiden tour of the solar system more than twenty years ago. A salvage claim like this could set Claire and her crew up for life. But a quick search of the ship reveals something isn't right.
Whispers in the dark. Flickers of movement. Messages scrawled in blood. Claire must fight to hold on to her sanity and find out what really happened on the Aurora before she and her crew meet the same ghastly fate.
"Truly un-put-downable in its purest sense." Chloe Gong, #1 New York Times bestselling author of These Violent Delights
S.A. BARNES works in a high school library by day, recommending reads, talking with students, and removing the occasional forgotten cheese-stick-as-bookmark. The author has published numerous novels across different genres, but Dead Silence is the first published as S. A. Barnes. Barnes lives in Illinois with more dogs and books than is advisable and a very patient spouse.
Fiction / Science Fiction / Action & Adventure
Fiction / Horror
Publisher: Tor Nightfire
"I ate this book in one sitting because I was in the mood to be freaked out and it delivered tremendously. Truly un-put-downable in its purest sense." —Chloe Gong, #1 New York Times bestselling author of These Violent Delights
"Stomach-turning, sinister space horror perfect for fans of Alien and Event Horizon." —Kendare Blake, #1 New York Times bestselling author
"At the intersection of science fiction and horror, Dead Silence is the ultimate haunted house story, in space." —Alma Katsu, author of The Deep and The Hunger
"This is great, immersive, atmospheric space horror that shows Barnes is a talented storyteller and proves that, despite rumors to the contrary, horror belongs in space." —Locus
"Dead Silence mixes horror, mystery and sci-fi into a thrill ride sure to shock you out of your reading rut. This is one of those time-warp books—the ones where you look away from the clock, then look back and it's suddenly way past your bedtime." —BookPage, Starred Review
"With a compelling haunted-house-in-space frame, excellent worldbuilding, vivid imagery, biting social commentary, sustained tension, and a storytelling style that seamlessly moves between the mortal danger of the present and Kovalik's unsettling past, this sf-horror blend will resonate loudly with readers." —Library Journal
"Barnes is giving you Titanic but make it scary, she's giving you Event Horizon, she's giving you Ghost Ship; for real, this book will make your skin crawl." —BookRiot
"This story slides and slithers from creepy and atmospheric to skin-crawling, edge-of-your-seat terror." —T. Kingfisher, author of What Moves the Dead
"Dead Silence gives you the suffocating claustrophobia of 2001: A Space Odyssey mixed with the horrors of Alien. I couldn't stop reading." —Mur Lafferty, Hugo Award-Winning author of Six Wakes
"Barnes ably conjures the kind of haunting setting and atmosphere required for this Event Horizon-esque novel... Recommended for fans of claustrophobic space horror." —Booklist
"Barnes plays nicely on human fears of both madness and of ghosts, carefully blurring the line between science fiction and horror... Those with a taste for blending genres will enjoy this combo." —Publishers Weekly
"Creepy and satisfying; I'll be checking under my bed tonight." —Sarah Pinsker, author of the Nebula Award winning A Song For A New Day
"I've always considered Alien the high mark of sci-fi horror. No longer. Dead Silence leaves it in the dust." —Lisa Shearin, New York Times bestselling author
"Dead Silence will keep you awake at night....Expertly paced, this novel is full of old ghosts in every way possible, and will haunt you long after the last page." —Laurie Faria Stolarz, author of Jane Anonymous
"I was turning pages long into the night, and the bags under my eyes are well worth it!" —Rachel Vincent, New York Times bestselling author of Red Wolf
"Compulsive reading at its best. A sci-fi horror so expertly delivered you'll be peeking through your fingers until the last page!" —Melissa Landers, author of the Alienated and Starflight series
"The richly realized world that S.A. Barnes creates draws us in, and the relatable characters charm us. The dread mounts to a powerful conclusion." —David Wellington, author of The Last Astronaut


This shampoo is described as the 'fluffy, shiny coat formula' and it does just that! Pomegranate Extract is a moisturiser and antioxidant, Cucumber Extract is a moisturiser and astringent, Lemongrass Oil aids natural shine and Peppermint Oil helps relieve itching. All blended together on a natural cleansing base, this shampoo is perfect for all coats, especially those who lack shine and body.


We typically offer a 30-day refund policy on our shared Web Hosting plans.
Where a refund is required, a client would need to open a ticket with our Billing Department to make a legitimate case on the subject matter. Each request would be subject to a review before it can be approved or otherwise.


An additional 7,434,367,256 ordinary shares of Lafarge Africa Plc (Lafarge) were listed on the Daily Official List of The Nigerian Stock Exchange on 26 March 2019.
The additional shares listed arose from Lafarge's Rights Issue of 7,434,367,256 ordinary shares of 50kobo each at #12 per share on the basis of 6 new ordinary shares for every 7 ordinary shares held as at 4 December 2018. The Rights Issue was 100% successful.
With this listing of the additional 7,434,367,256 ordinary shares, the total issued and fully paid up shares of Lafarge has now increased from 8,673,428,240 to 16,107,795,496 ordinary shares.
7. Lafarge Africa 2018 Rights Issue - To Accept or Renounce?


Tuberous sclerosis complex (TSC) is an inherited neurocutaneous condition in which benign tumors (called hamartomas) grow in the brain, kidneys, heart, eyes, lungs, and skin. Although the tumors are generally benign, they may cause medical complications due to their locations. Skin abnormalities, seizures, developmental delay, intellectual disability, autism spectrum disorder, and behavior problems are common in individuals with TSC. Although children are born with TSC, signs and symptoms may not be apparent until months or years after birth, and diagnosis may be delayed unless there is a strong family history or a cardiac rhabdomyoma is large enough to cause symptoms in an infant. Skin abnormalities also may lead to the diagnosis. A high variability of clinical expressivity exists among families and even within the same family.
ICD-10 for Tuberous Sclerosis provides further coding details.
TSC is inherited in an autosomal dominant manner, and the identification of a pathogenic mutation in either TSC1 or TSC2 confirms the diagnosis. There is high penetrance of TSC for those with a mutation in either gene, but 10-25% of individuals who fulfill clinical diagnostic criteria do not have a pathogenic mutation in either gene. Approximately 1/3 of children with TSC have a family history; the remaining 2/3 of children are thought to have TSC resulting from spontaneous mutations. The protein products of 2TSC1 and TSC2 interact in various signaling functions in cells that are important in regulating cell proliferation and growth (the mTOR pathway). TSC1, located on chromosome 9, encodes hamartin; TSC2, located on chromosome 16, encodes tuberin. Mutations in TSC2 are more common than in TSC1 and are generally associated with more severe clinical presentations. [Orlova: 2010] In families with TSC, mild and severe cases may appear within the same generation. Parents of a child with TSC could harbor a mutation of 1 of the 2 genes but not fulfill clinical diagnostic criteria. This reflects the variability of clinical expressivity of TSC and the possible low-level mosaicism in the unaffected parent who harbors either a TSC1 or TSC2 mutation.
TSC is a lifelong condition. Although most individuals with TSC have normal life expectancy, intractable seizures or malignancies in vital areas may cause disability and premature death.
The following articles offer consensus recommendations for diagnostic criteria and management of TSC. No formal practice guidelines have been published.
Tuberous sclerosis complex diagnostic criteria update: recommendations of the 2012 international tuberous sclerosis complex consensus conference.
Tuberous sclerosis complex surveillance and management: recommendations of the 2012 International Tuberous Sclerosis Complex Consensus Conference.
Roth J, Roach ES, Bartels U, Jóźwiak S, Koenig MK, Weiner HL, Franz DN, Wang HZ.
Subependymal giant cell astrocytoma: diagnosis, screening, and treatment. Recommendations from the International Tuberous Sclerosis Complex Consensus Conference 2012.
Teng JM, Cowen EW, Wataya-Kaneda M, Gosnell ES, Witman PM, Hebert AA, Mlynarczyk G, Soltani K, Darling TN.
Dermatologic and dental aspects of the 2012 International Tuberous Sclerosis Complex Consensus Statements.
The medical home clinician should watch for potential complications of TSC and provide anticipatory guidance. Use of the TSC-Associated Neuropsychiatric Disorders (TAND) Checklist is recommended. Optimal surveillance and management of clinical problems will involve collaboration with relevant subspecialists. In addition to well-child and acute-care visits, consider scheduling annual chronic-care visits.
Perinatal identification of cardiac tumor, especially in the intraventricular wall, should lead to consideration of TSC.
Infants with TSC may be very ill with respiratory distress, arrhythmias, and cardiomegaly due to cardiac rhabdomyomas.
About 5-15% of children and adolescents can have subependymal giant cell astrocytomas (SEGAs). Although they are benign tumors, they can cause serious neurologic problems, including hydrocephalus. Pay attention to unexplained changes in neurological status.
A contiguous gene deletion syndrome may cause both TSC and autosomal dominant polycystic kidney disease. These individuals have a higher risk than those with TSC alone of developing end-stage renal disease.
Of the individuals who fulfill clinical diagnostic criteria, 10-15% do not have a documented molecular etiology.
Genetic diagnostic criteria: The identification of either a TSC1 or TSC2 pathogenic mutation is sufficient to make a definite diagnosis. A pathogenic mutation is defined as a mutation that clearly inactivates either tuberin or hamartin or disrupts their respective functional activity.
When both LAM and renal AMLs are present, other manifestations must be present to diagnose TSC.
New diagnostic criteria do not address seizure disorders; nevertheless, clinicians should be aware of the association and consider the diagnosis of TSC for infants with infantile spasms and/or a hypsarrhythmic EEG pattern.
Infantile spasms, cortical dysplasia, renal cysts, dermal pits, developmental delay, and autism spectrum disorder all occur commonly in children who do not have TSC. Hypomelanotic macules alone may be seen in vitiligo, nevus anemicus, and piebaldism. Though isolated rhabdomyoma, angiofibroma, and LAM are not specific to TSC, each should trigger consideration of TSC. Facial angiofibromas can occur in Birt-Hogg-Dubé syndrome and multiple endocrine neoplasia type 1, although age of onset is later than in TSC.
Skin manifestations, including hypomelanotic macules, facial angiofibromas, shagreen patches, fibrous facial plaques, and ungual fibromas, occur in virtually everyone with TSC. None of the skin lesions is associated with medical complications such as skin cancer.
Brain manifestations include cortical tubers, subependymal nodules, SEGAs, and seizures. Some evidence suggests that the number of tubers correlates with the degree of intellectual disability and the number of seizures. [Goodman: 1997] Subependymal nodules (<1 cm) are present in 80% of patients but don't cause clinical problems. SEGAs are subependymal nodules that are >1 cm and located near the Foramen of Monroe. They occur in 5-15% of the patients and rarely develop after 25 years of age. They may enlarge and cause hydrocephalus by obstructing the ventricular outflow system and result in morbidity and death.
Kidney problems include AMLs and cysts. The majority of pre-teens with TSC have at least 1 renal lesion that tends to increase in size and number with time. Larger AMLs (>4cm in diameter) may abruptly bleed and become life-threatening, or they may replace normal renal tissue and lead to end-stage renal disease.
Heart problems include rhabdomyomas, which are generally present in infancy and regress spontaneously. They can cause arrhythmias in a minority of newborns, but require treatment only if they cause ventricular outlet obstruction.
LAM may occur, but it is usually seen only in adult females.
Inquire about newborn problems, symptoms of kidney problems, unusual spasms or movements, or seizure activity. In older children, inquire about relevant symptoms that include seizure frequency and severity, medication use, and symptoms of other organ system involvement, such as renal disease or shortness of breath. Ask about sleep problems, which may be caused by obstructive sleep apnea, and sleep problems related to seizures, autistic features, and intellectual disability.
Ask about a family history of TSC and the presence of hypomelanotic macules in family members (Woods lamp exam included). Obtain a 3-generation pedigree while keeping in mind the high degree of variability in clinical expression and the potential for parental mosaicism.
Obtain a standard history with emphasis on prenatal ultrasound and possible cardiac rhabdomyoma.
Assess family acceptance of the diagnosis and their ability to cope with complications of TSC.
Look for hypomelanotic macules, shagreen patches, facial angiofibromas, fibrous cephalic plaques, and ungual fibromas. Be aware that some skin features have an age-dependent course and might not be visible during the first exam. Use a Woods lamp under low-light conditions. Parents and siblings should also be examined for skin abnormalities as part of the genetic evaluation. It is not usually necessary to follow skin lesions unless they are particularly large or cause esthetic problems. Images of classic cutaneous manifestations for TSC can be found at Skin Features of TSC (TSAlliance.org).
Eye manifestations may include hypopigmented areas of the retina and retinal hamartomas. Teeth may have pitting. Intraoral fibromas may be present.
Screen for possible signs of LAM (exertional dyspnea, shortness of breath) in adolescent and adult women.
Monitor for unusual heart sounds or signs of cardiac failure, such as edema and shortness of breath.
Perform full neurologic exam as baseline. Changes in reflexes or papilledema may signal obstruction by a SEGA.
Although eye manifestations do not generally affect visual acuity, the initial evaluation should include a visual evaluation with dilated fundoscopy.
Children require ophthalmological screening before starting vigabatrin, and then screen at periodic intervals and after cessation. This should be arranged by the pediatric neurologist who initiates the medication.
Depending on the antiepileptic medication, children with seizures may need drug levels and/or other blood tests. Responsibility for monitoring may be worked out with the pediatric neurologist who initiated the medication.
Brain MRI at baseline to identify cortical tubers, subependymal nodules, and SEGAs. Repeat every 1-3 years in patients younger than age 25 years to monitor for new occurrence of SEGAs. Patients with a growing or even asymptomatic SEGA should have brain MRI as indicated for signs of increased intracranial pressure (frequency of scans in recommended range should be clinically determined).
Renal ultrasound (or abdominal MRI, when possible) every 1-3 years through lifetime to detect renal cysts and AMLs, as well as other non-renal hamartomas. The frequency of imaging is based on presence and size of lesions; MRI should be performed if larger lesions are found.
An EKG and echocardiogram should be performed at diagnosis. An EKG should be repeated every 3-5 years in asymptomatic children and adults.
A baseline EEG should be performed in all children upon diagnosis, especially in infants. EEG monitoring allows early detection of subclinical seizure activity and allows consideration of preventive treatment. [Curatolo: 2012] The frequency of follow-up EEGs in individuals with known seizures should be determined by the pediatric neurologist based on clinical needs.
Periodic neuropsychological and achievement testing should be performed through the school to assess progress and identify opportunities for focused interventions.
Adult women should receive pulmonary function testing.
Children who may have TSC should be referred for help with diagnosis. Patients and families should be referred for education about the condition and genetic counseling.
Seizures in TSC are often difficult to control; refer for needed expertise.
Refer for ongoing assessment and treatment that may be helpful for those children with intellectual disability, ADHD, autistic features, and behavior problems.
Refer, as needed, for evaluation and follow-up of renal lesions.
Refer if there are any concerns about cardiac function.
Although the eye lesions in TSC don't usually affect vision, an ophthalmologic exam is indicated to identify retinal abnormalities.
Referral may be helpful for concerns about lung problems and are needed for adolescent females for surveillance for LAM.
Children with sleep problems may benefit from sleep evaluations.
Individuals with large skin lesions, especially facial angiofibromas, may need referral.
Children on vigabatrin need frequent ophthalmological evaluations for retinal toxicity. Evaluations will generally be arranged by the pediatric neurologist.
Periodically screen for SEGAs using MRI. Image children with new headaches, particularly if the headaches are accompanied by vomiting.
Everolimus and sirolimus are effective in reducing the size of growing SEGAs and renal AMLs. Several reports of their off-label use have shown encouraging results in treating symptomatic cardiac rhabdomyomas and facial angiofibromas.
How should common problems be managed differently in children with Tuberous Sclerosis Complex (TSC)?
Neuropsychological testing prior to first grade should strongly be considered, even if preschool children appear to be doing well.
Vigabatrin is the recommended first-line therapy for infantile spasms in TSC and might be useful for focal seizures before age 1. However, the prescribing clinician should be aware of the possible side effects, including visual field constriction. [Curatolo: 2012] Data from clinical studies on mTOR inhibitors and control of seizures are promising, but not definitive.
mTOR inhibitors are also showing promise in treating other manifestations of TSC, such as seizures [EXIST-3 (clinicaltrials.gov)], non-renal hamartomas, cardiac rhabdomyomas, and facial angiofibromas (topical formulations); however, rapalogs are not yet approved for these indications.
Adolescent and adult women of childbearing age should be counseled regarding estrogen use because estrogen can worsen LAM.
Minimizing radiation exposure is recommended to diminish somatic mutations in the normal allele of either TSC1 or TSC2.
The TSA-associated neuropsychological disorders observed in patients are summarized by the umbrella term TAND, indicating the difficulties individuals can experience across multiple levels (intellectual, academic, psychiatric, psychological, behavioral, and social). [de: 2015] About half of individuals with TSC have intellectual disability and in up to 30%, the disability is severe. Even children with normal cognitive functioning often have specific learning disorders associated with school performances and executive/memory skills difficulties. [de: 2015] Features of autism are found in 17-61% of individuals with TSC, and behavior problems, such as ADHD (44%), self-injury (27%), and aggression (50%), are also common. [Wiznitzer: 2004] [D'Agati: 2009] [Eden: 2014] Anxiety and depressed mood can also be observed.
The Portal modules for Intellectual Disability, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder, and Depression , and Infantile Spasms provide diagnosis and management information for these conditions.
Periodic visits may be helpful for children with developmental delay, autistic features, and/or behavior problems.
Children <3 years old should be referred for evaluation and developmental therapies.
Children >3 years old should be referred to their local school districts for preschool services including developmental therapies.
Individuals of all ages with TSC may need more extensive educational neuropsychological evaluations for learning disabilities, cognitive impairment, and social communication issues.
Referral may be helpful for children significantly behind in gross motor skills.
Referral may be helpful for children significantly behind in fine motor and/or daily living skills.
Children with delayed speech/language may benefit from speech therapy.
Everolimus and sirolimus, which inhibit the mTOR pathway involved in cell proliferation, have been approved for treating SEGAs in both children and adults. [Franz: 2013] Periodic screening for SEGAs is accomplished using MRI, but children with new headaches, particularly accompanied by vomiting, should be imaged acutely. In the absence of new medical or behavior concerns, brain MRI with and without gadolinium is recommended every 1 to 3 years until age 25.
Seizures affect between 65-95% of individuals with TSC; refractory seizures, 20-50%. Seizure frequency may be related to the number of cortical tubers, although it is probably not the cortical tubers themselves, but surrounding tissue, that is epileptogenic. [Major: 2009] Seizures often manifest as infantile spasms, which can be difficult to treat and may be life-threatening. Vigabatrin is currently the drug of choice for infantile spasms associated with TSC, even though there may be retinal toxicity. Because vigabatrin can cause permanent peripheral visual field loss (thought to be due to drug-induced injury to photoreceptors and retinal ganglion cells and their axons), children require ophthalmological screening before starting vigabatrin, and then at periodic intervals and after cessation. Screening should be arranged by the pediatric neurologist who initiates the medication. [Kossoff: 2010] Adrenocorticotropic hormone (ACTH) and topiramate may also be used to control the infantile spasms, depending on pediatric neurology preference and expertise. In children with localizable foci of epileptogenic activity, surgery may be helpful. Another common type of seizure, focal seizures, can present at any age. Infantile spasms, earlier age at seizure onset, and drug resistance are usually associated with a worse cognitive outcome, which makes prompt and appropriate treatment crucial.
Children with seizures may need periodic consultation, depending on seizure frequency and response to medications. All pediatric patients with known TSC should undergo a baseline electroencephalograph (EEG).
Depending on local expertise, oncology may have a clinical protocol for treatment of intracranial tumors with rapamycin analogs (i.e., everolimus).
Suspicion of increased intracranial pressure should prompt a consultation. A team approach to cerebrospinal fluid (CSF) flow obstruction is needed to balance surgical and medical intervention.
About 80% of people with TSC are affected by renal abnormalities: renal AMLs affect 60% of people; renal cysts, 30%; and renal cell carcinoma, 2-4%. [Wataya-Kaneda: 2013] There is an age-related penetrance for renal AMLs. In the second decade of life, the prevalence jumps from about 10% up to 90% and size can increase; 1/3 of individuals with AMLs have lesions larger than 4 cm.
Periodic assessments may be helpful in the monitoring and managing renal lesions.
Mental health and behavioral issues in children with TSC can be complicated and will often require collaboration among developmental-behavioral pediatricians, psychologists, behavioral therapists, neurologists (particularly if the child is having seizures and is on anti-epileptic medication), and the rehabilitation team, including hospital-based and education-based therapists. For some children, psychiatry may be helpful. The correct diagnosis for behavioral problems is essential; for instance, a 7-year-old child with intellectual disability who is acting appropriately for his or her mental age, but has a short attention span, might benefit from ADHD medical intervention. The medical home should ensure that assessments of abilities and problems are frequent; use of the TSC-Associated Neuropsychiatric Disorders (TAND) Checklist is recommended. See the screening section (Tuberous Sclerosis Complex (TSC), Ongoing Assessment) for screening frequency and other details. In addition, counseling should be considered to help the family cope with the challenges of the condition.
Periodic visits may be helpful for children with developmental delay or intellectual disability, autistic features, and/or behavior problems.
Testing may help with diagnosis and management of intellectual disability, autistic features, ADHD, and/or behavior problems.
Testing may help with diagnosis and management of intellectual disability, autistic features, ADHD, and/or behavior problems, particularly in the setting of a child with seizures.
These programs may be helpful in the management of ADHD, autistic features, and/or behavior problems.
If a child is actively having seizures or is on antiepileptic medication, involvement is recommended in the joint management of behavior problems that could be associated with an underlying seizure disorder or side effects of anti-epileptic therapies.
In cases where behavior problems require medication, referral may be helpful.
Periodic visits are recommended for children with rhabdomyomas.
About 30-40% of adolescents and women develop LAM; the frequency increases to 80% in older women. Women may be asymptomatic and then present with progressive dyspnea during exercise and recurrent pneumothoraxes. LAM is rare in males. [Krueger: 2013] Sirolimus, an mTOR inhibitor, has been recently approved for treating LAM and should be used to improve pulmonary function in patients with rapid progression. Individuals with LAM should be advised to avoid smoking and using estrogen. Pregnancy might exacerbate LAM.
Periodic pulmonary function testing is advised In female adolescents.
Puberty is generally normal in individuals with TSC. Given the high variability of clinical expressivity, individuals with TSC should be properly counseled when entering reproductive age about reproductive options and the risk for having a child with TSC. Women with LAM should be advised about the potential negative effects of estrogen and pregnancy on LAM.
A consultation with a gynecologist familiar with working with children with special health care needs may be very helpful for the adolescent.
Consider referral if skin lesions are particularly large or cause esthetic problems.
Consider referral if lesion is symptomatic.
Children with intellectual disability or with specific learning disabilities will need accommodations in the school system. Depending on the degree of disability and the services needed by the child, a 504 plan or an Individualized Education Program (IEP) will be necessary. School Types and Options provides a discussion about federal laws regarding students with disabilities, the IEP process, and much more.
If I suspect TSC, what testing should I send?
The diagnosis of TSC is based on established diagnostic criteria (listed in module, above). [Northrup: 2013] Genetic testing can be useful in uncertain cases and for screening of family members once the pathogenic mutation has been identified. Consider starting with mutation analysis of TSC1 and TSC2 and, if negative, request deletion/duplication analysis of both genes. A mutation cannot be identified in 10-15% of patients, but this does not exclude the diagnosis.
In general, what is the minimum medical work-up to do after diagnosis of TSC?
Since TSC is a multisystemic condition, the initial studies should be aimed at determining the extent of the disease and organ involvement. Testing should include brain MRI, EEG, pediatric neurology evaluation, pediatric ophthalmology evaluation with fundoscopy, echocardiography/ECG, abdominal ultrasound/MRI, genetic evaluation (with assessment of skin findings, if dermatology is not available), and screens for TSC-associated neuropsychiatric disorders.
Will all patients with TSC develop intellectual disability?
No, while about half of the patients diagnosed with TSC have intellectual disability, which can vary from mild to profound, the other half have normal cognitive functioning. Some of these individuals, though, can experience specific learning or behavioral difficulties. Remember, there is a high clinical variability, even within the same family.
What are the most effective therapies for TSC?
Treatment in TSC is multidisciplinary and involves all specialists. Vigabatrin is the first-line treatment for infantile spasms, but possible visual side effects should be monitored. mTOR inhibitors (everolimus and sirolimus) are useful in treating SEGAs and renal AMLs. They also are showing promising results in leading to regression of other TSC-related tumors. Side effects are generally well tolerated, but the treatment might be lifelong.
Portal modules for Intellectual Disability, Attention Deficit Hyperactivity Disorder (ADHD), Autism Spectrum Disorder, Depression , and Infantile Spasms provide diagnosis and management information for these conditions.
Extensive review of TSC caused by mutation of the TSC1 gene; Online Mendelian Inheritance in Man.
Extensive review of TSC caused by mutation of the TSC2 gene; Online Mendelian Inheritance in Man.
A private, online portal for professionals from a variety of fields in TSC research, treatment, and education. Requires a free account to access site.
Information and photos for classic cutaneous manifestations of TSC that include hypomelanotic macules, facial angiofibromas, and shagreen patch.
Nonprofit organization that offers information, resources, and grants for research. The Healthcare Providers tab on the top of the page provides clinical diagnosis and management information. Other tabs provide information and resources for families affected by LAM and TSC.
PubMed search for tuberous sclerosis complex in children, last 4 years.
Curatolo P, Jóźwiak S, Nabbout R.
Management of epilepsy associated with tuberous sclerosis complex (TSC): clinical recommendations.
Henske EP, Jóźwiak S, Kingswood JC, Sampson JR, Thiele EA.
Mechanism-Based Treatment in Tuberous Sclerosis Complex.
Primary care management of tuberous sclerosis complex in children.
Wataya-Kaneda M, Tanaka M, Hamasaki T, Katayama I.
Trends in the prevalence of tuberous sclerosis complex manifestations: an epidemiological study of 166 Japanese patients.
A 12-question checklist designed to help guide decisions about further evaluation or treatment; free to download, screen takes about 10 minutes to complete.
Template that may be downloaded and edited to secure pre-authorization from insurance companies for diagnosis and management of TSC; Medical Home Portal.
A 32-page online booklet that provides information about diagnosis, features, genetics, and support systems for families affected by TSC.
Overview of TSC with emphasis on research and inclusion of links to studies and clinical trials; National Institute of Neurological Disorders and Stroke.
Overview with links to reliable sources of more detailed information; from the National Library of Medicine.
Excellent, detailed review of the condition for patients and families; sponsored by the U.S. National Library of Medicine.
Lists scientific articles, clinical trial, support, and advocacy networks related to TSC; compiled by the Genetic Alliance.
Information about TSC and additional resources for patients and families; Genetic and Rare Diseases Information Center.
Presents information, family stories, research results, and an interactive timeline illustrating the clinical features of TSC through life stages; Massachusetts General Hospital.
An online support community for individuals and families affected by TSC; sponsored by Inspire.com - membership required.
Locations of volunteer groups who work with the TS Alliance to facilitate local connections for individuals and families affected by TSC.
Provides advocacy, education, and other services for people affected by rare diseases.
A list of trials registered with the National Institutes of Health; some may be of interest and might offer opportunity to participate in research.
A list compiled and maintained by the Tuberous Sclerosis Alliance with clinical trials and clinical studies that have obtained Institutional Review Board approval.
Authors: David Viskochil, MD, Ph.D.
Reviewers: David Viskochil, MD, Ph.D.
Neuropsychiatric problems in tuberous sclerosis complex.
Management of subependymal giant cell tumors in tuberous sclerosis complex: the neurosurgeon's perspective.
Bissler JJ, Kingswood JC, Radzikowska E, Zonnenberg BA, Frost M, Belousova E, Sauter M, Nonomura N, Brakemeier S, de Vries PJ, Berkowitz N, Miao S, Segal S, Peyrard S, Budde K.
Everolimus for renal angiomyolipoma in patients with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis: extension of a randomized controlled trial.
Bissler JJ, Kingswood JC, Radzikowska E, Zonnenberg BA, Frost M, Belousova E, Sauter M, Nonomura N, Brakemeier S, de Vries PJ, Whittemore VH, Chen D, Sahmoud T, Shah G, Lincy J, Lebwohl D, Budde K.
Everolimus for angiomyolipoma associated with tuberous sclerosis complex or sporadic lymphangioleiomyomatosis (EXIST-2): a multicentre, randomised, double-blind, placebo-controlled trial.
Bombardieri R, Pinci M, Moavero R, Cerminara C, Curatolo P.
Early control of seizures improves long-term outcome in children with tuberous sclerosis complex.
Camposano SE, Major P, Halpern E, Thiele EA.
Vigabatrin in the treatment of childhood epilepsy: a retrospective chart review of efficacy and safety profile.
Chu-Shore CJ, Major P, Camposano S, Muzykewicz D, Thiele EA.
The natural history of epilepsy in tuberous sclerosis complex.
Colaneri M, Quarti A, Pozzi M.
Everolimus-induced near-resolution of giant cardiac rhabdomyomas and large renal angiomyolipoma in a newborn with tuberous sclerosis complex.
Curatolo P, Bjørnvold M, Dill PE, Ferreira JC, Feucht M, Hertzberg C, Jansen A, Jóźwiak S, Kingswood JC, Kotulska K, Macaya A, Moavero R, Nabbout R, Zonnenberg BA.
The Role of mTOR Inhibitors in the Treatment of Patients with Tuberous Sclerosis Complex: Evidence-based and Expert Opinions.
Curatolo P, Porfirio MC, Manzi B, Seri S.
D'Agati E, Moavero R, Cerminara C, Curatolo P.
Attention-deficit hyperactivity disorder (ADHD) and tuberous sclerosis complex.
Eden KE, de Vries PJ, Moss J, Richards C, Oliver C.
Self-injury and aggression in tuberous sclerosis complex: cross syndrome comparison and associated risk markers.
Franz DN, Belousova E, Sparagana S, Bebin EM, Frost M, Kuperman R, Witt O, Kohrman MH, Flamini JR, Wu JY, Curatolo P, de Vries PJ, Whittemore VH, Thiele EA, Ford JP, Shah G, Cauwel H, Lebwohl D, Sahmoud T, Jozwiak S.
Efficacy and safety of everolimus for subependymal giant cell astrocytomas associated with tuberous sclerosis complex (EXIST-1): a multicentre, randomised, placebo-controlled phase 3 trial.
Goodman M, Lamm SH, Engel A, Shepherd CW, Houser OW, Gomez MR.
Cortical tuber count: a biomarker indicating neurologic severity of tuberous sclerosis complex.
Günther T, Schreiber C, Noebauer C, Eicken A, Lange R.
Treatment strategies for pediatric patients with primary cardiac and pericardial tumors: a 30-year review.
Hong CH, Tu HP, Lin JR, Lee CH.
An estimation of the incidence of tuberous sclerosis complex by a nationwide retrospective cohort study from 1997 to 2010.
Perinatal (fetal and neonatal) tuberous sclerosis: a review.
Jóźwiak S, Sadowski K, Kotulska K, Schwartz RA.
Topical Use of Mammalian Target of Rapamycin (mTOR) Inhibitors in Tuberous Sclerosis Complex-A Comprehensive Review of the Literature.
Evidence-based, standardized approach for optimal clinical care provided for individuals with tuberous sclerosis complex.
Leclezio L, Jansen A, Whittemore VH, de Vries PJ.
Pilot validation of the tuberous sclerosis-associated neuropsychiatric disorders (TAND) checklist.
Major P, Rakowski S, Simon MV, Cheng ML, Eskandar E, Baron J, Leeman BA, Frosch MP, Thiele EA.
Are cortical tubers epileptogenic? Evidence from electrocorticography.
Northrup H, Koenig MK, Pearson DA, Au KS.
Key changes compared with 1998 criteria are the new inclusion of genetic testing results and reducing diagnostic classes from three (possible, probable, and definite) to two (possible, definite). Additional minor changes to specific criterion were made for additional clarification and simplification.
O'Callaghan FJ, Shiell AW, Osborne JP, Martyn CN.
Prevalence of tuberous sclerosis estimated by capture-recapture analysis.
Prather P, de Vries PJ.
Behavioral and cognitive aspects of tuberous sclerosis complex.
Seyam RM, Bissada NK, Kattan SA, Mokhtar AA, Aslam M, Fahmy WE, Mourad WA, Binmahfouz AA, Alzahrani HM, Hanash KA.
Changing trends in presentation, diagnosis and management of renal angiomyolipoma: comparison of sporadic and tuberous sclerosis complex-associated forms.
Eye Involvement in Tuberous Sclerosis Complex.
Tuberous Sclerosis Alliance; (2006) https://www.tsalliance.org/about-tsc/signs-and-symptoms-of-tsc/eyes/. Accessed on 12/2018.
de Vries PJ, Whittemore VH, Leclezio L, Byars AW, Dunn D, Ess KC, Hook D, King BH, Sahin M, Jansen A.
Tuberous sclerosis associated neuropsychiatric disorders (TAND) and the TAND Checklist.


This Mega Pack has 20 Shopkins! - Two on show and 18 hidden inside! Plus each pack comes with a tattoo sheet so you can show off your own Wild Style too! There are 20 tattoo sheets to collect! Will you be lucky enough to find the limited edition Shimmery Unicorns Tribe!


Shockingly, construction workers have the highest rate of current drug users (15.6%) out of any other industry in the United States, according to the US Department of Labor (US DOL). That's 4 percentage points higher than the next closest industry! The US DOL also states that workers under the influence of drugs or alcohol are 3.6 times more likely to be involved in an accident in the workplace and five times more likely to file a workers' compensation claim. Lost time and workers compensation claims by substance abusers is estimated to cost the economy over $240 BILLION dollars each year.
The Construction Coalition for a Drug- and Alcohol- Free Workplace (CCDAFW) was founded by the Associated Builders and Contractors, Inc (ABC) and The Associated General Contractors of America (AGC) and now also includes the Construction Industry Roundtable (CIRT), the Construction Users Roundtable (CURT), Independent Electrical Contractors (IEC), and the National Center for Construction Education and Research (NCCER).
These organizations have combined their efforts in an attempt to rid the construction industry of injuries and deaths connected to drugs and alcohol related accidents. To do so, the CCDAFW has created a pledge that contracting companies can sign to commit themselves to the idea of a substance free workplace and have made many free resources available to the companies to show their employees that they take this subject seriously. Among the resources are a model substance abuse policy, a state by state substance abuse testing policy, and several best practices documents created specifically for substance use reduction.
Over 2,000 construction companies have already signed the pledge, will your company be next? We hope so.


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Village People Radio Show () — документальный фильм 2007 года режиссёра . Стал продолжением фильма «Последний коммунист», и тоже был запрещён властями Малайзии.

Сюжет
Фильм рассказывает о жизни членов Малайской коммунистической партии — бывших бойцах , этнических малайцах, примиривших в себе коммунистическую идеологию и исламскую веру. В середине 1950-х годов, в связи с обострением противостояния с британскимим войсками, они начали стратегическое отступление и перешли границу Таиланда. Многие из не видели своих домов в течение пяти десятилетий. Когда, в начале 1980-х годов, правительство Китая восстановило дипломатические отношения с Малайзией, помощь из Пекина остановилась, жить стало сложнее и в 1989 году им пришлось подписать соглашение о формальном прекращении огня. Многие из членов полка все ещё живут в деревне в Южном Таиланде, зарабатывая на жизнь сельским хозяйством и больше не занимаясь политикой, но беспокоясь о своих детях, так как они могут навсегда потерять связь с родиной. Их воспоминания о десятилетиях борьбы с правительством прерываются вымышленной передачей по радио Шекспировской «Зимней сказки» — истории о короле, обвиняющим свою жену в прелюбодеянии, и держащем её в заточении — фактически притчи о отношении страны к партии.

Прокат
Премьера фильма состоялась в феврале 2007 года на 57-м Берлинском кинофестивале, а позже он был показан на фестивалях в Гонконге, Сингапуре и Дубае. Как и предыдущий фильм, этот был запрещён к показу на территории Малайзии за симпатии к коммунизму и нечувствительность к празднованию 60-летия страны.

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Фильмы 2007 года
Фильмы Малайзии
Фильмы на малайском языке
Фильмы на тайском языке
Фильмы о коммунизме
Документальные фильмы 2007 года


text:
End notes: A Portrait and a Personal History Revealed
Eleanor H. Gustafson December 5, 2022 Art
Happy Birthday Bélizaire. It's been two hundred years since your birth in 1822 and a long time since anyone knew who you were. For a while you were painted out altogether. But we are thrilled that you have reappeared, and that Jeremy K. Simien and Louisiana historian Katy Shannon have recovered your story
Bélizaire and the Frey Children attributed to Jacques Amans (1801–1888), c. 1837. Oil on canvas, 47 ¼ by 36 ¼ inches. Collection of Jeremy K. Simien; photograph by Selina McKane.
That story starts about a decade ago when Simien, a Creole, began to seek out furniture, paintings, and other objects that reflected his family's long history in Louisiana and came across the painting shown above online. None of the figures were identified, but the setting had been described as a Louisiana landscape. Intrigued, he finally persuaded the owner to sell him the painting and began working with Shannon to figure things out.
Relentless digging revealed that the three white children were Léontine, Elizabeth, and Frederick Jr., the eldest daughters and son of successful New Orleans entrepreneur and financier Frederick Frey, whose three-story home stood on Royal Street in the French Quarter, at what is today approximately the site of the Monteleone Hotel bar. Of greater interest to Simien, however, was the well-dressed and seemingly self-assured Black teenager, who stood just behind the children, and who, in fact, had been painted out of the portrait at some point in its history, then restored in the first decade of this century. (A recent cleaning and conservation has brought him and his personality even more clearly into focus.) Simien and Shannon agree that some sort of mystical connection brought them together and helped them identify the young man as the enslaved Bélizaire, whom the Freys bought when he was six, and ultimately sold more than thirty years later to the owners of Evergreen Plantation, where Shannon is head of history and interpretation. Open for debate is Bélizaire's exact role in the family, though there is no evidence that he was literally related to the Freys; most likely, he was simply a family favorite who attended the children.
Bélizaire and the Frey Children as it appeared before conservation c. 2005. Photograph courtesy of Jeremy K. Simien.
Pending further research, the painting is believed to be the work of the French-born artist Jacques Amans, newly arrived in New Orleans in 1837, about the time the work was done, judging by the children's ages, and later the city's premier portraitist. It dates from the height of Frey Sr.'s success—just before things began to go downhill for the family financially and personally. The two girls died soon after the painting was finished, probably of yellow fever, and Frederick Jr. a few years later. Recession hit, and Bélizaire was sold to pay off debts in 1841, though the family subsequently bought him back. Only he and the Freys' last child, not included in the portrait, lived to adulthood.
In many ways, Simien says, Bélizaire's story is a metaphor for so much of Black history in this country. The largest figure in the scene, he was subsequently eradicated, only to re-emerge as the most intriguing part of the story. "That's beautiful," Simien says.
The painting is on view at the Ogden Museum of Southern Art in New Orleans until October 2.
BélizaireendnotesOgden Museum of Southern ArtrestorationSeptember/October 2022


Few conversations focus on improving early elementary years, the linchpin of the pre-K-to-12 education system.
The value of pre-K has gained broad attention. From the White House to conservative states like Georgia and New Mexico to cities like San Antonio and New York, there is a growing recognition that providing children — especially the nation's expanding population of dual-language learner and low-income kids — with access to high-quality early learning opportunities can go a long way in helping children to be successful in school and later in life.
There has long been an emphasis on student achievement and success in grades 3-12. Debates abound on what the best school-improvement strategies look like, what makes for quality teaching, and whether state tests measure the right things. Federal and state education officials are taking action on each of these fronts.
Unfortunately, few conversations focus on improving kindergarten through third grade, the linchpin of the pre-K-to-12 education system. These years, some of the most crucial in a young child's intellectual and social development, are largely ignored. Kindergarten through second grade is at least equally important to what comes before and after.
At minimum, it marks the start of compulsory and guaranteed education for all students in just about every state and lays the foundation for all future learning. That is why it is important to establish a coordinated and cohesive pre-K through third grade continuum of learning that helps to ensure the gains children make are sustained and built upon up through the third grade, when children begin to tackle more challenging content.
Right now, the educational system fails to build that continuum on many fronts. Local schools and school districts often have little to no information on how many children are enrolled in pre-K programs, what types of curricula and teaching strategies have been used, or what children ultimately learned in those programs. In a 2012 New America report, authors Lisa Guernsey and Alex Holt said this sort of information is urgently needed to lay "the groundwork for alignment across the pre-K-third grade years, and building a strong foundation for their [children's] success in school." This information is also essential for kindergarten teachers who need to understand their students' preschool experiences.
As it stands, children's kindergarten paths vary considerably by their zip codes. In some states, parents can sign their child up for a daily kindergarten schedule that runs six to seven hours, just as long as a typical day in 1st grade. In other states, though, a "full-day kindergarten schedule" may only run four or five hours. Many school districts offer only half-day kindergarten classes. And in others still, families interested in more school time have the option to pay tuition and extend their child's kindergarten day.
Yet research makes clear a whole range of benefits that come with a full day of learning. More time in the day allows for more instructional time and gives young children additional opportunities to develop social skills. Teachers have the ability to dedicate more time to hands-on activities, exploration, and learning in subject areas beyond reading and math.
Perhaps most importantly, children attending full-day kindergarten experience better learning outcomes. Some studies find that kindergartners who attended for a full day made significant gains in early reading skills compared with children who attended for a half-day. In states where half-day kindergarten is an option, first-grade teachers often face the same dilemma as kindergarten teachers. They may leave behind those children who are struggling and bore those who arrived prepared or are already far ahead.
Making matters worse, some teachers do not have the skills and experience they need to effectively teach pre-K through third-grade students. Depending on the state, one teacher may be prepared in content and strategies primarily aimed at the upper elementary grades with limited emphasis on how younger children learn, how to actively engage them, recognize atypical development, or involve their families.
Another teacher may have taken courses that focus on developmentally appropriate practice, family engagement, and meeting the needs of diverse children, with less knowledge of subject areas and strategies for teaching them.
Principals can exacerbate the problem of instruction that is not appropriate for early grade students because they themselves often do not recognize what good teaching of young children looks like when they visit classrooms and provide feedback to teachers. Hint: It's not children sitting quietly listening to the teacher lecture. Instead, good instruction means actively engaging children in back-and-forth interactions that delve deep into the subject are they are learning, teaching through play and allowing opportunities for children to explore and investigate.
Finally, while it may seem like duck soup, there are few connections between pre-K programs and the early grades, even where pre-K programs operate inside elementary schools. It is not even the norm for schools to provide time for teachers across the early grades to plan or discuss student progress together, much less include teachers from pre-K programs in these discussions.
If the goal is to build on children's pre-K and other early childhood experiences and ensure that they are able to read and do math at grade level by the end of third grade, then more focus is sorely needed on improving children's transition from pre-K into elementary school and on the quality of teaching and learning environments in pre-kindergarten through third grades.
States need to improve the quality of teacher and principal preparation programs, requiring them to give teachers and leaders solid grounding in how young children develop and learn best. Districts need to help connect schools with pre-K programs operating in the same area. Schools should support opportunities across pre-K and the early grades for joint professional development, data sharing and developing a common understanding of expectations for learning across the continuum. States need to require districts to offer full-day kindergarten, so that every child has access to a more equitable and enriching kindergarten experience. And the federal government should offer incentives to states and school districts that commit to doing these and other activities to help improve children's learning outcomes in all the early grades.
This work becomes even more essential as the population of low-income children, dual-language learners, and children of color expands. Sometime in the next five years, children of color — with standard and special learning needs — will make up the majority of the nation's young child population. Unfortunately, they are also the students least likely to have access to high-quality pre-K programs or elementary schools.
While the focus on high-quality pre-K expansion is necessary, and efforts to improve the quality of teaching and learning in third through 12th grade are imperative, policymakers must not forget to also strengthen and build connections to the linchpin of the educational system: kindergarten through second grade.
Laura Bornfreund is the deputy director of the New America Foundation's Early Education Initiative.
Laura Bornfreund is the deputy director of New America's Early Education Initiative.


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live outside a radius of 25 miles of LS2 and move within this distance to take up the post.
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USA News Hub
TV tonight: David Cameron, Boris Johnson and François Hollande on Putin's war
Erdogan suggests Turkey may allow Finland to join NATO, block Sweden
'It just didn't feel right': top Iran chess player on why she removed headscarf
The routine played out each time Iran's Sara Khadem travelled abroad for chess tournaments – between contemplating openings and sizing up her opponents, the top-ranked chess player kept a constant eye on the cameras that roamed the hall, pulling off her headscarf as soon as they stopped rolling.
But when the invite arrived for a tournament in Kazakhstan in December – Khadem's first in three years – the 25-year-old knew she no longer wanted to keep up the pretence.
"It felt, let's say, unfaithful to people if I had gone with the headscarf," she said. "It just didn't feel right."
Soon after, Khadem, Iran's top female chess player and ranked 17th in the world among female chess players, landed in Almaty. Photos began circulating of her, deep in thought and her hair uncovered, as she took on opponents at the Fide World Rapid and Blitz Championships.
As the hijab is compulsory for women under Iranian law, some saw Khadem's decision as a sign of support for the protests that have gripped Iran since the death of Mahsa Amini while in custody. The Iranian-Kurdish woman was being held by the country's morality police after being arrested for allegedly breaching Iran's strict dress code for women.
For Khadem and her husband, film-maker Ardeshir Ahmadi, the tournament appearance marked a turning point; since the birth of their son last year, the couple had been weighing a move to safer country.
The timeline was pushed forward by Khadem's tournament appearance, said Ahmadi. "She told me, 'I would love to go to the tournament but I'm not going to wear the hijab,'" said the 32-year-old. "I said 'OK, if that's your decision, I support you and we can go to Spain.'"
The couple and their 11-month-old son landed in the country in early January, their path to residency eased by her status as an elite athlete and a property they owned in the country.
"I heard rumours that we did this to get asylum or something so that we can move to Spain," said Khadem, who is also known as Sarasadat Khademalsharieh. "I just want to be clear that we didn't use any political reasons to move out because we didn't need that."
Khadem is the fifth female grandmaster to leave Iran in recent years – several of them moving abroad after playing internationally without a headscarf. Khadem's departure, however, has played out against the backdrop of the protest movement that has swept Iran in recent months.
Authorities in Iran have sought to crack down on the demonstrations, executing at least four people and arresting more than 19,500 people, according to the group Human Rights Activists in Iran. More than 500 protesters are believed to have died. Iranian authorities have not provided official figures on deaths or arrests.
Even as Khadem has worked to untangle her relocation from the protest movement – describing the move to Spain as a "family decision" on social media – the country's politics have followed the family.
Safety concerns have forced the couple to keep secret their exact location in Spain. Khadem emphasised that she alone made the decision to forsake the headscarf. "If I would have to answer to somebody about this, I think it should be me and not the family."
The couple has sought to keep a low profile in their new country, said Ahmadi. "What she did is not considered political in most countries," he added. "But in Iran, everything is political."
His view is coloured by experience; in 2014, Ahmadi was detained in Iran's Dastgerd prison for three months, after an arrest believed to be linked to a documentary he made about an underground band.
As the couple seeks to put the past behind them and settle into their new lives in Spain, their focus is now on rebuilding Khadem's career after a years-long hiatus brought on by the pandemic and the birth of her son. The move to Spain has allowed her to delve deeply into the game she fell in love with when she was eight years old.
She is planning to represent Iran in international tournaments, in a nod to the homeland to which the couple eventually hopes to return. "The decision I made in Almaty was a personal decision," she said. "So when I go back to Iran – as I'm sure I will – I will answer to those who ask me what I felt."
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World Entrepreneur
Innovation & Tech
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Which Virus Are We Fighting?
Summer Like No Other
In the lives of many people, this will be the summer in which there was no sea, no holiday, no socialising with friends, and the summer in which some lost their loved ones and others lost their jobs. Perhaps we'll also remember it as the moment of birth of a new world in which a government based on fear suppresses democracy
In this area we've remembered summers in which we faced scarcity, the collapse of the country and war, but we've never before had a summer in which we had the same, uniform and invisible enemy that is both global and local, both in us and among us. It has already resulted in multiple consequences that we are yet to face in terms of health, the economy and society. We spoke with our interlocutors about the unusual times in which we live and the personal and social responses to the threat confronting us.
Branka Drašković Ph.D., FEFA Faculty
We Expect Responsibility And Compassion From Leaders
Opinion 2 August 2020
During serious crises, all eyes are directed towards leaders and they are expected to provide guidelines, to express what everyone feels, to articulate further...
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Governments worldwide have used the fear of the virus to legitimise fear as a social and political resource. It can hence be said that...
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The state is obliged not to bury its head in the sand, but rather to simultaneously develop several scenarios for the time to come,...
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Living 2 August 2020
We previously had an enemy that was external and was the cause of our suffering, and we had someone to be angry with. At...
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text:
<!DOCTYPE html>

<link rel="stylesheet" href="../style.css"/>

Processing.js

LoadFile1

Loads a text file that contains two numbers separated by a tab ('\t').
A new pair of numbers is loaded each frame and used to draw a point on the screen.

Original Processing.org Example: LoadFile1

<canvas width="200" height="200"></canvas>

// All Examples Written by Casey Reas and Ben Fry
// unless otherwise stated.
String[] lines;
int index = 0;

void setup() {
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}

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redpajama_set_name: RedPajamaGithub


text:
Jonathan Hodgson
Jonathan covers the Saskatoon Blades and the Victoria Royals of the WHL. He has extensive experience in hockey and sports journalism and broadcasting. This includes bylines at Sports Spectrum, Toronto Blue Jays, Victoria Grizzlies, DUBNetwork as well as a long-time role with the Canadian Baseball Network.
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4 Saskatoon Blades Milestones Within Reach
Jonathan Hodgson | January 31, 2021
The recent news that the Western Hockey League has received approval from the Government of Alberta and Alberta Health to return to play has renewed optimism about a 2020-21 season…
Victoria Royals Matured Under Head Coach Dave Lowry
Every time Dave Lowry took the reins as head coach in the Western Hockey League, he has made his team better. Now in his first season as an assistant with the…
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A trio of brothers are forging a family hockey legacy and putting their hometown on the hockey map in the process. Hockey fans around the world were introduced to Vegas…
Canada Names All-WHL Leadership Group For 2021 WJC
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They've been described by head coach Andre Tourigny as a three-headed leadership monster. Team Canada made it official on Friday, naming their leadership group for the 2021 World Junior Championship…
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Team Canada will have a distinctly western feel at the 2021 World Junior Championship, and it has nothing to do with where the tournament is being played. The defending WJC…
Victoria Royals' History at the World Juniors
The Victoria Royals are certainly still a young franchise in the Western Hockey League, having relocated from Chilliwack, B.C. less than a decade ago. Still, they have built a strong…
Victoria Royals' Derungs Vying for Spot on Team Switzerland at 2021 WJC
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On the heels of playing his first season in North America with the Victoria Royals in 2019-20, winger Keanu Derungs is attending Switzerland's selection camp for the upcoming 2021 World…
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This time of year, the thoughts of Canadian hockey fans center around the annual tradition that is the World Junior Championship. For a few weeks every season, the best junior…
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Saskatoon Blades general manager Colin Priestner was moving and shaking at the 2018 Western Hockey League trade deadline. With the Blades in the midst of a mediocre 2017-18 season and…
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Meet Quorum Analytics cofounders Alex Wirth, 21, and Jonathan Marks, 22. Their clients include Holland & Knight, the United Nations Foundation and General Motors.
Quorum cofounders Alex Wirth and Jonathan Marks have some data-driven fixes for Capitol Hill.
A few weeks ago Alex Wirth, a boyish-looking 21-year-old, and his former roommate, 22-year-old Jonathan Marks, were picking up their college diplomas.
Now, they're running a company in D.C.
Launched in January, Quorum Analytics grew out of Wirth's frustrations with Capitol Hill and was incubated on the campus of Harvard University.
Wirth was rather well connected for a summer intern. The son of a New Mexico state senator and grandnephew of former Sen. Tim Wirth (D-Colo.), he used to crash on the couch of TrackMaven CEO Allen Gannett.
And yet, he felt worn down by the complexities of networking in D.C., after working here as a Senate Page and then interning for Sen. Jeff Bingaman (D-N.M.).
When he organized a campaign to create a Presidential Youth Council, he realized that advocacy was real shoe-leather work — inefficiently so.
In the fall of 2013, he shared his experience with his roommate, Marks, a chemical and physical biology major who saw a problem that needed a data fix.
That was followed by months of consulting with former chiefs of staffs of members of Congress, lobbyists and staffers. The two young men were looking for a scientific solution to the crustiness of lobbying.
Their questions boiled down to: Who should you talk with to further your agenda? Which button should you push?
Quorum's flagship product, a sort of pin cushion-shaped graph depicting with whom members of Congress have collaborated on bills, aims to map these relationships.
The data analysis helped prove that women in Congress are better at reaching across the aisle and closing deals than their male counterparts, according to a New York Times article.
But Wirth and Marks found other common Capitol Hill brunt work that could be simplified with software and data.
Quorum also offers a text comparison program that highlights changes in bills and a visualization of Census Bureau data mapped onto Congressional districts.
The software pulls its data from the Library of Congress, the websites and tweets of members of Congress, floor statements, Census data, committee websites and so on.
"It's all scraped using Python to pull it in," said Wirth.
Since it publicly launched in January, Quorum Analytics' client base has quadrupled in size and the company is already making a profit, Wirth said.
It charges $4,800 per year per user from big-name groups like the lobbying firm Holland & Knight, the United Nations Foundation, the First Focus Campaign for Children and several Fortune 500 companies, including General Motors.
Quorum is still officially bootstrapped.
The company started off with close to $90,000 collected from business plan competitions, including grants from the Harvard College Innovation Challenge and Harvard Institute of Politics Gov 2.0.
In May, Quorum won the Live Free in D.C. contest launched by the Washington, DC Economic Partnership at the SXSW festival.
They moved here in June, receiving free living accommodations and work space at Canvas.
The company's team of recent and current college students — all younger than Wirth and Marks — works from three separate spaces, including a house in Foxhall and offices near Farragut Square.
In June, Quorum also launched the First Look Program, a free trial for the most "competitive" interns who apply.