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Imaging-guided gene delivery: seeing is delivering : Journal of Bio-X Research
Editorial, Legal, and Ethical Policies
Thought you might appreciate this item(s) I saw in Journal of Bio-X Research.
Imaging-guided gene delivery: seeing is delivering
Qu, Shuai; Liu, Renfa; Dai, Zhifei*,
Department of Biomedical Engineering, College of Future Technology, National Biomedical Imaging Center, Peking University, Beijing, China
SQ and RL contributed equally to the writing of the article.
Received: 08 August 2022; Accepted: 24 August 2022
*Corresponding author: Zhifei Dai, Department of Biomedical Engineering, College of Future Technology, National Biomedical Imaging Center, Peking University, Beijing 100871, China. E-mail: [email protected]
Journal of Bio-XResearch 5(4):p 143-144, December 2022. | DOI: 10.1097/JBR.0000000000000133
To the editor:Gene therapy is considered a promising treatment option for several diseases, including neuromuscular disease, cardiovascular diseases, immunodeficiencies, and cancer. However, the promise of gene therapy is largely compromised by a lack of suitable gene delivery systems.[1,2] Gene delivery approaches using common gene vectors including viral and nonviral vectors typically rely on specific targeting moieties or tissue tropism of the vectors. However, not all tissues possess unique receptors suitable for targeted gene delivery. This issue can be potentially solved by introducing external physical stimuli, such as ultrasound, magnetic force, heat, and light, which can guide the transgene expression independent of the intrinsic properties of the cells of interest.[3–5] In addition, such physical stimuli can be integrated with medical imaging, thus making imaging-guided gene delivery possible. In this scenario, physical stimuli are applied to the area of interest guided by medical imaging and can then trigger robust transgene expression in selected areas.
Recently, our team reported such a strategy that integrates ultrasound imaging, microbubbles (MBs), and adeno-associated virus (AAV) vectors for noninvasive spatial control of transgene expression in mouse artery.[6] In our study, a clinical diagnostic ultrasound imaging system, which is also used for clinical carotid ultrasound imaging, was used for simultaneously imaging and generating ultrasound stimuli. With color Doppler ultrasound imaging, the mouse's carotid artery can be clearly visualized, and a region of interest can be randomly selected on the image, allowing the ultrasound to be focused on that region. Following the injection of MBs, the MBs can be selectively blasted in the region of interest by the ultrasound wave used for imaging, thereby increasing the permeability of the tissue in the selected region. The transient permeability changes can induce highly increased accumulation of AAVs and, thereby, robust transgene expression (Fig. 1). The transgene expression in arterial endothelial cells was increased by ~24-fold and persisted for >8 weeks. In addition, transgene expression in the vascular media and adventitia was also increased by approximately 86-fold. In theory, this ultrasound- and MB-guided AAV strategy can be used for gene delivery in all blood vessels that can be seen by ultrasound imaging. We have validated the feasibility of this strategy in the mouse carotid and femoral arteries and abdominal aorta. We also tested this strategy for gene therapy of atherosclerosis in a mouse model.[6]
The combination of ultrasound, MBs, and AAVs represents a unique strategy to achieve imaging-guided gene delivery. AAV gene vectors are the leading platform for gene delivery due to their capability to transduce a wide range of cell types in vivo. With the help of ultrasound and MBs, AAV gene vectors can induce potent transgene expression with spatial specificity in a noninvasive manner. In an earlier report by Szablowski et al,[7] a similar strategy was utilized to apply imaging-guided gene delivery to neurons for selective control over individual brain regions in a mouse model of memory formation. Focused ultrasound guided by magnetic resonance imaging was used to selectively open the blood–brain barrier in combination with MBs, which induced specific transgene expression by AAVs. In addition, cell-specific promoters were applied to confer the cell specificity of this strategy.[7]
Considering that ultrasound and MBs are widely used in clinical settings and AAVs have been verified in several clinical trials,[8] this strategy can be clinically translatable. However, further improvements are still needed. For example, instead of the one-dimensional array ultrasound probe used here, the use of two-dimensional probes could facilitate the scaling of the ultrasound- and MB-guided AAV strategy to larger animals. At the same time, three-dimensional real-time ultrasound imaging could make the ultrasound imaging and MB destruction more precise. Additional work is also warranted to make the AAV gene vectors more efficient in order to lower the required doses. The use of more robust cell-specific promoters could reduce nonspecific transgene expression in major organs. Considering the high price and potential safety issues of AAV gene vectors, developing nonviral alternatives, such as nucleic acid-loaded lipid or polymer nanoparticles, is needed.[2]
In summary, we believe combinatorial image-guided gene delivery holds tremendous potential, with many aspects still unexplored, to overcome several critical challenges faced by gene therapy today and significantly expand its clinical utility.
Figure 1.:
UMGAAV paradigm. In the UMGAAV sequence, the mouse artery can be visualized by ultrasound imaging. After injecting microbubbles, microbubbles can be selectively destroyed with ultrasound wave generated by the imaging probe under color Doppler mode, increasing the permeability of artery endothelium. Then the injected adeno-associated virus (AAV) can specifically accumulate in the ultrasound-treated area, resulting in targeted transgene expression in mouse artery.
SQ, RL, and ZD designed, wrote and edited the manuscript. All authors approved the final version of the manuscript.
This work was financially supported by National Natural Science Foundation of China (No. 81930047, to ZD; No. 82102062 to RL) and China Postdoctoral Science Foundation (No. 2020TQ0008, to RL).
The authors declare that they have no conflicts of interest.
Editor note: ZD is an Editorial Board member of Journal of Bio-X Research. He was blinded from reviewing or making decisions on the manuscript. The article was subject to the journal's standard procedures, with peer review handled independently of this Editorial Board member and their research groups.
[1]. Dunbar CE, High KA, Joung JK, et al. Gene therapy comes of age. Science 2018;359:eaan4672.
[2]. Qu S, Liu RF, Zhang NS, et al. Non-viral nucleic acid therapeutics: Revolutionizing the landscape of atherosclerotic treatment. Nano Today 2022;45:101514.
[3]. Zhu H, Zhang L, Tong S, et al. Spatial control of in vivo CRISPR-Cas9 genome editing via nanomagnets. Nat Biomed Eng 2019;3:126–136.
PubMed | CrossRef |
[4]. Chertok B, Langer R, Anderson DG. Spatial control of gene expression by nanocarriers using heparin masking and ultrasound-targeted microbubble destruction. ACS Nano 2016;10:7267–7278.
[5]. Miller IC, Zamat A, Sun LK, et al. Enhanced intratumoural activity of CAR T cells engineered to produce immunomodulators under photothermal control. Nat Biomed Eng 2021;5:1348–1359.
[6]. Liu R, Qu S, Xu Y, et al. Spatial control of robust transgene expression in mouse artery endothelium under ultrasound guidance. Signal Transduct Target Ther 2022;7:225.
[7]. Szablowski JO, Lee-Gosselin A, Lue B, et al. Acoustically targeted chemogenetics for the non-invasive control of neural circuits. Nat Biomed Eng 2018;2:475–484.
[8]. Kuzmin DA, Shutova MV, Johnston NR, et al. The clinical landscape for AAV gene therapies. Nat Rev Drug Discov 2021;20:173–174.
Copyright © 2022 The Chinese Medical Association, Published by Wolters Kluwer Health, Inc.
Journal of Bio-X Research5(4):143-144, December 2022.
Articles in PubMed by Shuai Qu
Articles in Google Scholar by Shuai Qu
Other articles in this journal by Shuai Qu
The Chinese Medical Association


Join for Song exercise at 3.30.
Jim Jarmusch has come up with something strange and amazing in "Ghost Dog"– an existential fable. Original indie-hipster Jim Jarmusch ("Strasnger than Paradise,"Down By Law") seems to be well outside his usual territory here, yet "Ghost Dog" not only hangs together, it's original, sharply funny, and rather moving. An ancient samurai code, embodied by Forest Whitaker as a lone hitman, runs smack into mob family values in this modern urban battleground.
Look at taize.fr about Taizé and their prayers.
Sign in for preparing on the list attached on the fridge at Sandgatan.
Lära känna katolsk tro – nu några gånger om bönen, vad det innebär, och olika böneformer.
– two films and dinner between.
A less-known Bergman movie, yet among his most alluring. Andreas Winkelman (played by Bergman favourite Max von Sydow) moves to a barren island, in grief of his recently deceased wife. He befriends his neighbours, the widow Anna (Liv Ullman) and a married couple (Bibi Andersson and Erland Josephson). The island, as well as its inhabitants, keeps many threatening secrets.
Meal–bring things for the table!
Some hours together walking in nature, taking bus there, bringing picnic.
Here are some more stories trom our trip to Istanbul in June… A travel with many subjects, but basically about: Us as Christians from Western Europe, meeting with other people, different from us in traditions, religion, history.
We prepared the trip since September last year (9 month for this baby to be born…) with conferences on Byzantine life, Turkish mosques, Alevi (islamic religious minority) prayers, with dinners and films, seminars on texts we read and prepared for each others: byzantine and ottoman history, turkish culture, religous life and social and political situation.
"What struck me particularly during our visit to the city centre of Istanbul was what could be called some kind of "rural friendliness", two words one would not intuitively apply to a city of nearly 20 million inhabitants.
Rural, in the way that the city centre seems to be composed of many distinct neighbourhoods where time seems to follow the pace of quiet, self-contained village life. Beyond the busy and sometimes chaotic boulevards – graceful only by name – you will find elderly men taking their time in the local eatery or outside the mosque, craftsmen in their open workshops, women chatting in the streets with their children playing nearby and occasional poultry taking a stroll to soothe the boredom of the backyard: all pictures we imagine belong to the countryside. Indeed, there is not really a city centre in the European sense – i.e. a comprehensive city planning, where monuments, squares, parks etc. are related to each other with avenues and a more or less coherent architecture. Instead, mosques and other monuments often seem to emerge out of the "nowhere" that is the dense organic maze of streets, houses and courtyards.
Friendly and informal, in the way that people do not seem to have been infected with the arrogance and self-absorbedness that often comes with being the biggest and the best. The village-scale of many districts is welcoming in itself and not once did I have a feeling of insecurity, be it in the crowded bazaar area or in a dim-lit back street.
"An eclectic landscape, whose single guiding line seems to be drawn by the mosques, a society with a composite face, mosaic of cultures, religions, life stories, cemented by Islam: that is how Istanbul appeared to my eyes. Istanbul has been a meeting point over History. A meeting point…what a wonderful place to meet people!
And the journey was the occasion of several meetings, coming from different origins, each one experienced with a different intensity: first of all the ones that emerged from our group, then the meeting with the town and its inhabitants, and finally the opportunities given by the speakers we met, and who led us into the intimacy of the city.
I would particularly remember my meeting with the Islamic world. I first of all got to know that the mosque, more than a prayer area, is a social place, in times past the centre of a complex, which could include a Koranic school, a hospital, a hammam, shops. I learnt that Islam could be mystical and lead the believer to an intimate relationship to God. During the Friday evening prayers at Eyüp, I got caught by the intensity radiating from this gathering of believers, all members of the same body, all carried by the same dynamic, all breathing as one.
Hello, our film evenings are interesting events with quality films and discussions afterwords. We gather many different people with different views – both Christians and others. Some ar more familiar with the art of film, others just look in, and hopefully they discover something.
We live in a time of images and there is really too much of them. When we look at film at Sandgatan we therefore choose films carefully – not just entertainment, but something that adds a perpective on life. The discussion afterwards is essential, that the image is accompanied with a word, a reflection- It´s often surprising events, when the eyes of the other, the reflection of the other ,widens the perspective and understanding.
This autumn there are films by Eric Rohmer, Ingemar Bergman and Jim Jarmusch.
Éric Rohmer (1920–2010) might be the archetypical French director: charmful, witty, intellectually intense, talkative. A part of the New Wave scene, Rohmer was impressingly consistent over his vital 60 years of production. His output is manifold. His films can be seen as delightful trifles, but to its core, Rohmer's work leaps through mazes of human psychology, especially the intricate verbal games people play when trying to justify their desires. Inside often lures a moral conundrum, e.g. in our first Rohmer film.
Jim Jarmusch, American film director, is a champion of independent cinema who broke Hooywood conventions with his highly inventive narratives, deadpan humour and endearing character studies. He has created some of the most original, amusing and sublime landmark movies in underground cinema, in springtime we saw three of them, now we´re back with two others. Concentrating and the small details of daily life, as opposed to the big events, his observational films often reflect a nocturnal subculture.
Ingmar Bergman (1918 – 2007) was by all accounts the greatest Swedish director ever to work in cinema. Through a career spanning almost sixty years, Bergman meticulously documented every facet of the human psyche. His films are sustained meditations on the human condition, whether it be existential angst in the face of mortality and faith, or the difficulties of leading a fulfilling life among our fellow human beings.
Film Day – two films and dinner inbetween. Bring things for the table!
The antagonist Frédéric (Bernard Verley) is happily married and expecting a child with his wife. One day, Chloé (played by 60's and 70's icon Zouzou) shows up at Frédéric's office. Frédéric knows Chloé as a femme fatale, the two are acquaintances from the past and they now reshape a friendship. Their meeting makes Frédéric reassess his situation.
Night on Earth assembles five moments in time, in taxicabs, in the middle of the night, in five of the world's cities. At the end, we have learned no great lessons and arrived at no thrilling conclusions, but we have shared the community of the night, when people are unbuttoned and vulnerable – more ready to speak about what's really on their minds.
Mixing poetic mysticism, violence and droll comedy, "Dead Man" stars Johnny Depp as Willim Blake, a meek, naive accountant who travels from Cleveland to the godforsaken town of Machine, there to assume a position with the Dickinson Metal Works. That metaphysical context benefits enormously from the haunting musical themes that Neil Young wrote, underlining the film's psychedelic/apocalyptic edge, and from the stunning black-and-white camera work.


this is your spiritual act of worship." Romans 12:1 NIV.
Life is a precious, priceless gift. Never regard life as expendable, insignificant, or to be cheaply given. Yet Jesus issued a crucial call to discipleship. "If anyone would come after Me, he must deny himself and take up his cross daily and follow Me." Luke 9:23 NIV. In 1956, Jim Elliot, a 28-year-old missionary pilot, was one of five missionaries martyred by Huaorani Indians in Ecuador. In his personal journal, he had written, "He is no fool who gives up what he cannot keep to gain what he cannot lose." How very true!
Jesus issued a monumental challenge that still resonates within the heart that He created, "Whoever wants to save his life will lose it, but whoever loses his life for Me will save it." Luke 9:24 NIV. Jesus does not depreciate your life as unimportant or without supreme value. But what did Jesus mean when He required that you, "lose your life"? Would it mean to trade a few years here for an eternity with God? Could it mean to live for something and Someone much greater than yourself? Yes, that must be it, sacrificing something you treasure for something that you would treasure even more, as well as forever.
Jesus was unapologetic when He said, "And everyone who has left houses or brothers or sisters or father or mother or children or fields for My sake will receive a hundred times as much and will inherit eternal life." Matthew 19:29-30 NIV. Squandering your life is a terrible waste, while sacrificing your life for God is a noble gift. Heed Jesus' warning, "For whoever wants to save his life will lose it, but whoever loses his life for Me will save it. What good is it for a man to gain the whole world, and yet lose or forfeit his very self?" Luke 9:24-25 NIV. The Great Exchange is when you joyfully surrender what was formerly most precious to you to receive what you never imagined could be yours.
Today, I pray for you to surrender your life as a worthy gift given back to God.
Good Friday is a day unlike any other before or since. On this day, Jesus of Nazareth, the Son of God and Sovereign of Heaven's Kingdom, died for the sins of all the world. On His head was a crown, but not one you would suppose the Son of God should have worn. He wore a crown of cruel thorns, not a gold, bejeweled crown a Sovereign would wear. Heaven's royalty was subjected to earth's worst cruelty. Those thorns were twisted together by the hands of mocking soldiers who saw nothing more than a common criminal who would die for his crimes. To them He was no more than another day's work in a troublesome province of Rome's conquest.
Some years ago, while in England with my friend, Andrew took me to tour the Tower of London where the spectacular, British Crown Jewels are kept. The priceless Crown Jewels are displayed in a collection of such incomparable beauty and incalculable value, being worn only by the monarchs and royal families of Great Britain across centuries. In cruel contrast, the crown Jesus wore was common not priceless, of pain not beauty, imposed with rejection and ridicule not recognition or honor.
Anyone familiar with this part of Texas knows about mesquite thorns, an inch or more long, hard as a nail, and sharp as a needle. They can puncture a tire or shoe, and never break. The thorns of Palestine were much like that. And that cruel crown was painfully forced deep into Jesus' scalp where the nerves and blood vessels are closest to the skin, resulting in immediate and immense pain and profuse bleeding. It was our sins not His that pressed them into His brow.
From where did those thorns come? Thorns came from the original sin in the Garden of Eden. To Adam and Eve, God said, "The ground is cursed for your sake . . thorns it shall bring forth for you." Genesis 3:17-18. Appropriately, His crown of thorns represented the consequence of your sins and mine. Isaiah wrote, "But He was wounded for our transgressions, He was bruised for our iniquities; the chastisement for our peace was upon Him . . and the Lord has laid on Him the iniquity of us all." Read Isaiah 53:3-6 NKJV.
But Jesus wore that crown of shame and pain that would have been yours, and mine. In the great exchange of redemption, Jesus wore your crown that spoke of sin and judgment, to give you His crown, "the crown of righteousness, which the Lord, the righteous Judge, will give to me on that Day, and not to me only but also to all who have loved His appearing." 2 Timothy 4:8 NKJV. But Easter – His resurrection – promises a greater day will yet dawn when God shall have "crowned (our Lord) with glory and honor." Psalm 8:5 NIV.
His crown of thorns that spoke of our sin has been exchanged for a crown of glory that testifies of our salvation. "We see Jesus . . now crowned with glory and honor because He suffered death, so that by the grace of God He might taste death for everyone." Hebrews 2:9 NIV. Read Psalm 21:3-6 NLT. No wonder we call this Friday good!
Today, I pray for you to reflect on the awful, awesome price Jesus paid for your salvation.
"God is our refuge and strength, an ever-present help in trouble." Psalm 46:1 NIV.
John marveled at the mystery of incarnation, "He was in the world, and though the world was made through Him, the world did not recognize Him. He came to that which was His own, but His own did not receive Him." John 1:10-11 NIV. In similar ways, God is daily in our lives, yet we can fail to recognize and receive Him. Live in expectation of His company. This I have learned about my God. He chooses to come at unforeseen moments, to improbable places, and in unthinkable ways. Without announcement, God comes while we are busy in common, everyday routines.
Fleeing from his father and brother because of his own guile and deceit, Jacob found himself alone, and yet not alone because God was there. After an uncertain, restless night, Jacob awakened. Only then did Jacob finally realize that God had visited him in the night, providing direction for his journey and speaking promises to his heart. More in surprise than expectation, Jacob recognized, "Surely, the Lord is in this place, and I was not aware of it." Genesis 28:16 NIV. God is there when you are unaware or least anticipate He is near. Much later, David would affirm, "God is our refuge and strength, an ever-present help in trouble." Psalm 46:1 NIV.
By observation, I have become convinced that God is most near when I least anticipate, even the times when I have most needed but often felt the least like asking. As with Jacob, the Lord is not with you because you have everything in order, nor just when you recognize you most need Him to be. God seeks your fellowship, continually desiring to be with you, near you. Yet the patience of God waits for you to recognize and welcome His presence. His love draws Him to you; His commitment keeps Him close beside you. God's Word promises, "Surely, I am with you always, to the very end of the age . . God has said, never will I leave you, never will I forsake you." Matthew 28:20 NIV/Hebrews 13:5 NIV. Currently. Constantly. God is with you always.
Years earlier, I read this quote, "There's no event so commonplace but that God is present . . leaving room to recognize Him, or not." Frederick Buechner, American author and theologian. Usually, the problem is that you do not know when or how God will appear, or through whom He will speak. He may speak through a wondrous act of power; a friend's simple words of caution, counsel, or encouragement; or life-saving counsel in a distressing situation. Your goal should be to keep your eyes upon the Lord, with your ears tuned to His voice. In unlikely times, give God your undivided attention.
"You will seek Me and find Me when you search for Me with all your heart." Jeremiah 29:13 NKJV. Adam found God in his disobedience. Job found God in his tribulation. Jonah found God in his disobedience. Elijah found God in his despair. Daniel found God in a lions' den. David found God in his repentance. Peter found God in his denial. Paul found God in a shipwreck. John found God while in exile on Patmos. "God did this so that men would seek Him and perhaps reach out for Him and find Him, though He is not far from each one of us. 'For in Him we live and move and have our being." Acts 17:27-28 NIV.
Today, I pray for you to watch for God in ordinary times and extraordinary ways.


Known in the whole world, it is one of the most beautiful royal flower parks. In the first place it is recognizable by its fields of tulip, which grows over seven million flowers and rare hybrids.
Winters in the Netherlands can be long, dark, and rainy.Keukenhof Garden is the most beautiful spring garden in the world.
This is one of the world's largest flower gardens, opened only from mid March to mid May. Every year, more than 7 million flower bulbs are planted in this park.
Keukenhof is the largest bulb flower garden park in the world, set in 32 hectares and originally opened in 1949. It is located in the small town of Lisse about 25km south-west of Amsterdam.
Keukenhof is located in South Holland in the small town of Lisse, south of Haarlem and southwest of Amsterdam. It is accessible by bus from the train stations of Haarlem, Leiden and Schiphol or with a direct transfer from Amsterdam City Center. Keukenhof is located in an area called the "Dune and Bulb Region" (Duin- en Bollenstreek).
In addition to the huge flower garden, the Keukenhof is also the largest statue garden of the Netherlands. You can admire many statues made by national and international artist.
Keukenhof in the Netherlands claims to be the world's largest flower park. Each year, Keukenhof is open only two months in spring each year to show off the best of Dutch tulips, crocuses, narcissus (daffodils), and other bulb flowers.
The gardens are beautifully landscaped and contain some 7 million flowers – all hand planted – including many rare varieties of tulips and a fine collection of orchids.
The best time to visit Keukenhof depends on the weather but mid-April is usually the most reliable for tulips. The garden is usually quieter early morning or late afternoon than around lunch time.
Spring flowers are a product by nature, the weather has got a big influence on it. When the weather is cold the tulips are growing much slower than when the weather is warm. A cold winter and springtime will cause that the flowers are blossoming later than normal. A warm winter and springtime causes the opposite.
Keukenhof is one big party for childeren. Keukenhof garden is a great day out for the whole family.
Gardens and parks are a wonderful example of how a man , in close connection with nature. Some of them are so beautiful that , I can call today's miracles of the world.
Wonderful park, and your photography is magnificent. congratulations.
I love nature, and I see you. Your photos are very beautiful.Thank you, and I congratulate you.
I want you to go again, and again feel the magic of the wild but beautiful nature.
I agree with you completely that the number of such places, the world would be more beautiful.
It's wonderful agree, words are not necessary, it is enough to go and enjoy the world of fairy tales, which is man-made.
Gorgeous, dream to visit this place one day.
When you believe in something, you realized. Dreams are achievable, you just have to trust and work on them. Your Maya.
Yeah you are right, all dreams are achievable ,, we just have to believe that it is and believe in ourselves.. thank you for the encouraging words.


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Indian Idol: Former Aspirant Reveals SHOCKING 'REALITY'; Mini Mathur Says 'RIP Organic, Pure TV'!
www.mangaloretoday.com
Recently, a former aspirant revealed shocking and harsh reality of Indian Idol on Twitter. He shared in his thread his traumatic experience of auditioning at the popular singing reality show. He revealed -how the contestants waited for a long time for the auditions, and there were no accessible toilets, food stalls, drinking water taps, e.t.c. He also revealed in his thread how the crew who was in charge of the auditions was abusive and even slapped and roughed up an aspirant! Like many of them, we too are shocked by the shocking and harsh 'reality' statements given out by the aspirant of the reality show! Apparently, Sony TV has declined to comment on the incidents mentioned in the thread. TV host Mini Mathur has responded to the aspirant Nishant's tweets and reveals why she bowed out of the reality show! Read the twitter thread that's going viral!
Nishant Kaushik Opened Up About His Audition Experience
"Brief, nonchalant thread about my auditioning experience at Indian Idol 2012 and why I think it is a perfect platform to destroy your dreams as opposed to its common perception as a breeding ground for talent." - (sic) "May. Mumbai. I rocked up at the venue more out of casual interest. On joining a queue 2 km long I noticed enthusiasts who had arrived there as though their lives depended on them. Some with their mothers holding Prasad, other rebels who had braved odds and traveled alone." - (sic)
"Joined The Queue At 7 AM; Gate Opens 1 PM"
"I joined the queue at 7 AM. There were people who had arrived at 5 AM. Others who had camped overnight. False notion that early arrival = early audition. No one from the crew to dispel such notions. Gate opens at 1 PM." - (sic) "In those long hours of waiting, no accessible toilets or food stalls or drinking water taps. If you step out in search, you risk losing the queue which you'd then have to rejoin. Anyway at 1 pm the long wait ended right? Wrong." - (sic)
"A Volunteer Amongst Us Was Sought To Go And Grab Shriram's Feet!"
"At 1 PM we were headed toward a stage on the school ground where the previous year's winner Shriram was lip syncing to Desi Boyz. A volunteer amongst us was sought to go and grab Shriram's feet mid-performance and shout "I wanna be Indian Idol!" Reward promised: early audition." - (sic) "Sure enough, one aspirant fell to the bait. Fell at Shriram's feet. Dozens of retakes demanded by the director. When the aspirant said he couldn't do any more retakes, assistants on the set abused him and threatened to have him off the auditions if he didn't comply. He complied." - (sic)
Contestants Who Made Enquiries Were Showered With Vile Abuses!
"These staged gimmicks went on till 5 pm. By this time, we had noticed that for a venue as large as a school and for a crowd in tens of thousands, the provisions were: 1 canister of water with a steel glass bang in the middle of the ground, and 1 toilet." - (sic) "When we asked the crew if we could step out to get lunch and water, we were told to do so at our own risk. As if auditions would begin any moment. Contestants who made inquiries about the actual commencement of auditions were either not responded to, or showered with vile abuses." - (sic) "(Quick digression to let you know that the contestant who fell at Shriram's feet like a hundred times in the lure of "early audition" never got an early audition. I bear testimony)." - (sic)
"First The Vultures Came With Their Mic And Cameras To The Blind Man"
"During all this I met two interesting aspirants: one med rep from an Indian village I don't remember the name of, who dragged his right foot in a broken slipper. And another, who was blind in both eyes. And then I saw the crew make a merciless meal of both of these kind souls." - (sic)
"First the vultures came with their mic and cameras to the blind man, who said he had a scene's role in The Slumdog Millionaire. They first asked him to give a little speech about the history and status of his blindness, how does it feel to be blind, and what have you." - (sic)
"Then they asked about his family. He said he had a mother who was now dead, leaving him orphaned and all by himself. Sudden twinkle in crew's eyes because they now had meaty content for a camera shot. They probed him in several ways on "what brings you here"." - (sic)
"They Drafted A Response On His Behalf"
"When none of his responses flew, they drafted a "response" on his behalf and read it out. Roughly, "I miss my mother and I wish she were here to see me, but I hope that when I sing tonight she can hear me up there." They made him repeat this even as his voice trembled." - (sic)
"Hours passed by. At around 8 PM, we were finally given badges and ushered in. no auditions yet. We were taken to the basketball court where for hours at stretch we were made to scream "We LOVE INDIAN IDOL!" right before our voices were supposedly going to be tested." - (sic)
One Of The Crew Members Slapped A Contestant
"At this point one of the aspirants lost his shit and stood up, demanding to see where the auditions were happening, to see the judges. One of the crew members charged up to him and slapped him. In front of thousands of people. SLAPPED.A.CONTESTANT. Yes this happened." - (sic) "A scuffle followed. Crew members rescued their colleague who was assaulted, by dragging the contestant along the floor and evicting him from the room. Late into the night, we finally arrived in a corridor that had a line of rooms hosting the auditions." - (sic)
"They Giggled At The Contestants Who Sang Horribly"
"(Take a moment to reflect that by the time of the first round of audition some of us had been standing at that venue for almost 24 hours). Crew walked past us, randomly picking some of us to sing a couple of lines. Just like that, in the corridor, with no judges present." - (sic) "The naive thought this was a smart way to quicken the filtering process of worthy contestants. The smartass crew knew better. They giggled at the contestants who sang horribly and directed them to the only room that had a camera inside it. The rest of us got non-camera rooms." - (sic)
"Mockery Went On"
"The med rep with that broken slipper I told you about sang atrociously. Through a half-open door of the room with the camera, I overheard his "auditioning". A painfully bad rendition of "Likhe jo khat tujhe", to which the judges kept going "wah wah! now try a higher pitch?"" - (sic)
"That mockery went on. The judges relished that fellow's naivety, asking him to keep taking a pitch "higher and louder" till his voice turned into frail shrieks that sent them into peals of laughter. He came out in tears. Elsewhere in the corridor we heard of contestants fainting." - (sic) "I crashed out in Round 3 of the auditions close to midnight, and was nearly relieved when it happened. But I went home satisfied that I got a taste of a show that on TV had always appeared alluring. Shocked as I was by its reality, I was a wiser man by the end of the day." - (sic)
"I Don't Even Have The Heart To Mention How We Were Witness To The Abuses"
"My summarized observation of Indian Idol was that it decorates and recognizes maybe 10 or less, very worthy participants annually. But en route it quashes a million people's hearts by disrespecting them, ridiculing and abusing them, denying them a conducive atmosphere to contest." - (sic) "Not to mention the laborers who were hired to install and then disassemble the equipment at the venue. I don't even have the heart to mention how we were witness to the abuses they were being subjected to by the present staff." - (sic)
"We Will Never Let TRP Hungry Channels Tell Us Otherwise"
"True talent is rare. But every aspiring artist's pride stems from the encouragement it gets from its colleagues and friends and mohallawallahs and family. In those little nooks and crannies, each of them is a "star". Reality shows have no right to disrespect that. "- (sic)
"Thank you all for your responses. We have amazing people like you who have the wisdom to understand that artists flourish when they foster positivity and an atmosphere of mutual encouragement. And we will never let TRP hungry channels tell us otherwise." - (sic)
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text:
This Restaurant In Attard Is Perfect For Coeliac And Lactose Intolerant Pizza Lovers
By Chris Peregin
Sometimes it feels like a new pizzeria opens every other day in Malta. And yet, it's virtually impossible to find a good place that takes the poor coeliacs and those cursed with lactose-intolerance seriously.
Thankfully, one restaurant in Attard has made this part of its manifesto. According to its Facebook page, Wood and Coal is run by an award winning pizzaiolo Gilbert Portelli who has "given a new taste to traditional, gourmet, and gluten free pizzas by combining a mixture of grains and seeds to obtain a full bodied, yet lighter pizza".
Sounds good, right? It is. The dough is fluffy AF, crispy on the crust and insanely delicious. And there's none of that gooey aftertaste so typical with gluten-free products. This is really impressive. And definitely among the best gluten-free pizzas on the island. This Bologna pizza, with pistacchio pesto and mortadella was €11, which I thought was fair.
But it's not just pizza that is being offered by Wood & Coal. The large restaurant also has an extensive menu, featuring every kind of meat imaginable, gourmet burgers, a variety of pasta and lots more. Again, everything seems to be available gluten or lactose free at no extra charge. Isn't that awesome?
The restaurant is in Triq iż-Żgħafran, quite a busy main road in Attard, which means that the entrance isn't too enticing but parking is not a problem. Once you're inside, the decor is pretty basic but the friendly staff will make you feel very comfortable.
Wood and Coal is open for lunch and dinner, plus it accepts takeaways. It's quiet around lunchtime so it's a great place to get some privacy for a business meeting or a laptop date. It's also perfect for larger groups, especially if you've got a few coeliacs and lactose nerds among you.
Know someone who's been craving gluten and lactose free pizza? Tag them!
READ NEXT: 9 Great Places To Have A Working Lunch In Malta
We Tried Plastic Free Grocery Shopping At This New Supermarket In Malta And Here's What Went Down
From Tomahawks To Corn Dogs, This Gżira Bistro Is Sure To Satisfy Any Craving
8 Happy Hours: An Ode To A Sliema Restaurant That Really Knows How to Please
Grub's Up! This Naxxar Restaurant Has Some Seriously Scrumptious Snacks You Need To Check Out


text:
Tag: Exciton
Quantum Mechanics is Falsifiable.
One concept which exists in Science, is that certain theories are Falsifiable. This means that a given hypothesis will predict some sort of experimental outcome, which other theories would not predict, and then an experiment can be performed to test whether this outcome is according to the theory. If it is not, then this test will break the theory, and will thus falsify it.
Quantum Mechanics is often Falsifiable. If the reader thinks it is not, then maybe the reader is confusing Quantum Mechanics with String Theory, which is supposedly not falsifiable? And thinking that String Theory is just the same thing as Quantum-Mechanics, is a bit like thinking that Cosmology is just the same thing as Astronomy.
There is an aspect to a theory being Falsifiable, which I did not spell out above, assuming that the reader could infer it. But certain conversations I've had with people I personally know, suggest that those people do not understand this concept.
The result of a physical experiment can easily be, that the outcome is according to the theory. Just as much as the inverse situation would falsify the theory, such an outcome can eventually confirm the theory, and without confirming the theory, there is no real way in which Scientists can know, whether a new theory is in fact valid.
There is no specific imperative to prove a theory wrong, in the theory being Falsifiable. )
One aspect to how this posting should be read, which some readers might infer, but which other readers might not infer, is that it begins by stating a hypothesis. At first, I declared this hypothesis as distinct from several other theoretical explanations of light.
But it would break the flow of a blog-posting, if every paragraph which I wrote after that, began with a redeclaration, stating that the truth of the paragraph depends on the initial hypothesis.
This dependency should be assumed, and belongs to my intended meaning. )
According to Quantum Mechanics, light can be polarized, just as it can according to the classical, wave-based theory of light. Only, because according to Quantum-Mechanics light is driven by particles – by photons – its explanation of polarization is quite different from polarized light, according to the classical, electrodynamic explanation.
According to wave-based light, plane-polarized light is the primary phenomenon, and circular-polarized light is secondary. Circular-polarized light would follow, when waves of light are polarized in two planes at right-angles to each other, but when these waves also have a 90⁰ phase-shift.
(Edit 02/20/2018: A Hypothesis which I've just disproved, but which this whole posting's validity depends on.) According to Quantum-Mechanics, the photon is in itself a circular-polarized quantum of light, of which there can trivially be left- and right-handed examples. According to Quantum-Mechanics, plane-polarized light forms, when left- and right-handed photons pair up, so that their electrostatic components form constructive interference in one plane, while canceling at right-angles to that plane.
From a thermodynamic point of view, there is little reason to doubt that photons could do this, since the particles which make up matter are always agitated, and since the photons in an original light-source also have some random basis. So a conventional plane-polarizing filter, of the kind that we used to attach to our film-cameras, would not be so hard to explain. It would just need to phase-shift the present left-handed photons in one way, while phase-shifting the present right-handed ones oppositely, until they line up.
But there exists one area in which the predictions of Quantum-Mechanics do not match those of classical wave-mechanics. If we are given a digital camera that accepts lens-attachments, we will want to attach circular polarizing filters, instead of plane-polarizing filters. And the classical explanation of what a circular polarizer does, is first to act as a plane-polarizer, which thereby selects a plane of polarization which we want our camera to be sensitive to, but the output of which is next circularly-polarized, so that light reaches the autofocus mechanism of the camera, which is still not plane-polarized. Apparently, fully plane-polarized light will cause the autofocus to fail.
This behavior of a polarizer is easily explained according to Quantum-Mechanics. The plane-polarized light which is at first admitted by our filter, already possesses left- and right-handed photons. After that, we could visualize sorting out the photons that are circular-polarized in the wrong direction.
But the opposite behavior of a filter would not be predicted by Quantum-Mechanics. According to that, if we first pass randomly-polarized light through a circular polarizer, and if we then pass the resulting beam into a plane-polarizer, we should not be able to obtain plane-polarized output from the last polarizer.
According to the classical explanation of light, this should still be an easy thing to do. Our circularly-polarized light is supposed to have two components at right-angles, and our plane-polarizer should only allow vibration in one plane. But according to Quantum-Mechanics, if the incident beam is already circularly-polarized, it should only consist of either left-handed or right-handed photons, and then a simple filter should not be able to conjure photons that are not present in the original beam. And so our circularly-polarized light should not be convertible into plane-polarized light.
Continue reading Quantum Mechanics is Falsifiable.
Posted on April 25, 2017 February 20, 2018 Tags Angular Momentum, birefringence, Circular Polarization, Circularly-Polarized, Conservation, Energy, Exciton, Falsifiable, Phase-Shift, Phonon, Photon, Plane-Polarized, Plasmon, Polariton, Quantum Mechanics, Quasiparticle, Refraction, Spin-Flip3 Comments


text:
Alessandro "Sandro" Pellegrini (* 4. Juli 1938 in Mezzolombardo; † 8. März 1998) war ein italienischer Politiker aus Südtirol.

Biographie
Pellegrini absolvierte eine landwirtschaftliche Fachschule und arbeitete anschließend als Beamter. Von 1974 bis 1988 vertrat er die Democrazia Cristiana (DC) im Bozner Gemeinderat, von 1976 bis 1985 wirkte er gleichzeitig auch als Stadtrat, zuletzt als Fraktionssprecher. Der auch im Verbandswesen aktive Pellegrini rückte 1990 für den verstorbenen Aldo Balzarini in den Südtiroler Landtag und damit gleichzeitig den Regionalrat Trentino-Südtirol nach, denen er bis zum Ende der Legislaturperiode 1993 angehörte. Unmittelbar nach Amtsantritt wurde er Landtagsvizepräsident, 1991 übernahm er dann turnusgemäß die Landtagspräsidentschaft. Nach dem Rücktritt Remo Ferrettis Anfang 1993 wechselte er in die Landesregierung, in der er bis Februar 1994 im Kabinett Durnwalder I als Landesrat für Finanzen, Vermögen, italienische Schule und Kultur fungierte. Parallel dazu war er von 1990 bis 1994 Assessor und Vizepräsident in der Regionalregierung Trentino-Südtirol.

Literatur
 Südtiroler Landesregierung (Hrsg.): Südtirol-Handbuch 1993. Broschüre, Bozen 1993, S. 90 (online)

Weblinks

Landtagspräsident (Südtirol)
Landtagsvizepräsident (Südtirol)
Landesrat (Südtirol)
Vizepräsident (Trentino-Südtirol)
Politiker (Bozen)
Mitglied der Democrazia Cristiana
Italiener
Geboren 1938
Gestorben 1998
Mann

redpajama_set_name: RedPajamaWikipedia


The Walk Across Kansas effort was featured in the recently published Chancellor's Report 2014.
June 27, 2012 – Sandra Billinger, PT, PhD, FAHA, has been appointed vice chairperson of the American Heart Association's Rehabilitation and Recovery Committee. This committee is part of the Stroke Council, one of 16 scientific councils within the American Heart Association uniquely dedicated to advancing the science of stroke prevention, treatment and recovery through research and education.
An assistant professor in the KU Department of Physical Therapy and Rehabilitation Science, Billinger has served on the committee for two years prior to her selection as vice chair. Rehabilitation and recovery from stroke is a rapidly growing area with increasing significance to community health. By promoting the science behind recovery, the committee will foster leadership and collaboration among clinicians and scientists in the field.
Billinger leads the Georgia Holland Research in Exercise and Cardiovascular Health laboratory located on the ground floor of the Hemenway Life Sciences building at the KU Medical Center in Kansas City, Kan.


Each CD of CHORUSES includes music to match the lyrics you get in the corresponding Wisdom Book.
The WiseGuys program begins with the importance that God places on WISDOM. Our theme verse is Proverbs 16:16: "How much better is it to get wisdom than gold and to get understanding rather to be chosen than silver." This verse is the foundation of the WiseGuys program. The wise person realizes the value of obeying God's Word. Each boy and girl is encouraged to obey the scriptures they memorize ~ that's being WISE.
Wisdom is: "Hearing and obeying God's Word"
How is trust in God demonstrated in our lives? Trusting God is knowing that He loves me and wants me to be with Him forever. Trusting God is knowing that He has a plan for my life. Trusting God is placing my eternal soul into His hands. Why can't I do the same thing with my life?
Trust is: "Placing my life in God's hands"
How do you like to be treated? Do you like to be treated with kind words and actions? This month the boys and girls are encouraged to practice KINDNESS at home, with their family; at school, with their friends; and in everything they do. Some kind words are 'thank you' and 'please'. Tommy discovers that counting to 10 keeps angry words from coming out of his mouth.
Kindness is: "Treating others the way you want to be treated"
This month the boys and girls learn the importance of 'always doing their best'. Why are we to do our best? 'Doing our best' is called diligence in the Bible. We find out that the diligent person will one day be the boss; the slothful person will be the slave. Doing our best has it's own rewards! Good things happen to Tommy this month as he learns to do his best!
Diligence is: "Always doing my best for God and others"
This month the boys and girls learn what to do when they are enticed to do wrong. Proverbs tell them 'to consent thou not' when sinners entice them. That's saying 'NO!'. It's not easy to be the only one to say 'no'. That's why it's called COURAGE!
Courage is: "Saying 'NO' when the crowd says 'yes'"


Stevie Wonder did debut with The Jazzsoul of Stevie Wonder at the age of 11 years old, was a beginning which showed their amazing skills playing the drums, bongos, harmonica and keyboards. Also demonstrated his skills as a composer on some issues.
Disco with a touch of jazz instrumental sounds advanced for its time. Berry Gordy renamed him with Little Stevie and also decided to show the small facet instrumentalist Stevie, pending a mature voice, was still of child-this child prodigy.
With the production of the composer also for Motown, Clarence Paul, a producer in the early years of the Temptations and co-composer of some of the hits of Stevie, and others great artist as Marvin Gaye.


Faith meets fashion in this handsomely styled religious ring for him. The sleek cross sits atop white diamond rounds in an intricate octagon design and pave setting. With 1/5 carat T.W. and a cross adorning each side, this ring is the perfect statement piece. Silvertone.


text:
Board Openings
Backlash Hike with Engineering with Mike Massimino
Posted by Bharat Sharma on
Event : Backlash 2017
Location: Mountain View, CA
RSVP here: WWE Backlash 2017 online
All Columbia alumni, parents and friends are invited to attend a conversation with Mike Massimino, '84 and NASA astronaut, and Mary Boyce, Dean of Engineering. Extreme Engineering is part of a series of talks with leaders in engineering and applied science that highlight the intersection of exploration and innovation. Mike Massimino is a Professor of Professional Practice at the School of Engineering and Applied Science and former NASA astronaut. A veteran of two space flights, (STS-109 in March 2002 and STS-125 in May 2009) Massimino has logged a total of 571 hours and 47 minutes in space, and a cumulative total of 30 hours and 4 minutes of spacewalking in four spacewalks.
San, CA 940403
Did a host refer you? No Bharat Sharma
Invite your friends to join you
by email on Facebook on Twitter
CAA Alumni Events Worldwide
SITE PROVIDED BY
Are you an alumni group leader? Please contact your liaison in the Office of Alumni Relations or email [email protected] to learn how to create an alumni group website.
Content on this page is the responsibility of the Columbia alumni organization represented here, and does not reflect the official views of Columbia University. If you have any concerns about this page, please e-mail [email protected]


I'm sure a few readers have teenage daughters who have read the entire Twilight series of books 15 times like mine has. One thing many of the old fuddy duddies may not realize is that cars play a starring role in the books. It seems that vampires like cars. Cool cars. Fast cars. In book one Bella, the smitten by vamp girl, rocks around town in a tres cool vintage pickup while the object of her affections drives a silver Volvo S60 turbo. Somehow in the movie it became a C30. Without spoiling much for those of you who haven't read the books (yes, I'll admit I have) one of the bloodsuckers rips off a yellow Porsche 911 Turbo for a fast getaway. Pretty inconspicuous huh?
After the break is a quick video of a stunt double leaving the set in Alice Cullen's toy. I sure hope that's a stunt double, or Alice has lost some of her appeal. Fortunately, the 911 is as hot as ever.


text:
<?php

namespace app\modules\admin\models;

use Yii;
use yii\base\Model;
use yii\data\ActiveDataProvider;
use app\models\Categories;

/**
 * CategoriesSearch represents the model behind the search form about `app\models\Categories`.
 */
class CategoriesSearch extends Categories
{
    /**
     * @inheritdoc
     */
    public function rules()
    {
        return [
            [['category_id', 'parent_category_id'], 'integer'],
            [['category_name'], 'safe'],
        ];
    }

    /**
     * @inheritdoc
     */
    public function scenarios()
    {
        // bypass scenarios() implementation in the parent class
        return Model::scenarios();
    }

    /**
     * Creates data provider instance with search query applied
     *
     * @param array $params
     *
     * @return ActiveDataProvider
     */
    public function search($params)
    {
        $query = Categories::find();

        // add conditions that should always apply here

        $dataProvider = new ActiveDataProvider([
            'query' => $query,
        ]);

        $this->load($params);

        if (!$this->validate()) {
            // uncomment the following line if you do not want to return any records when validation fails
            // $query->where('0=1');
            return $dataProvider;
        }

        // grid filtering conditions
        $query->andFilterWhere([
            'category_id' => $this->category_id,
            'parent_category_id' => $this->parent_category_id,
        ]);

        $query->andFilterWhere(['like', 'category_name', $this->category_name]);

        return $dataProvider;
    }
}

redpajama_set_name: RedPajamaGithub


It's the most wonderful time of year! Not only is December the month of my birthday, it's also a month where we get to make lots of memories that will last a life time with my little ones, family and friends.
We have lots of traditions around this time of year that have become dear to our hearts and with a new little one in the family this year, I'm definitely looking forward to sharing our family traditions with her. Even though she's only four months and can't really participate in our family traditions, just having her in the room with us is good enough.
Every family has special holiday traditions, which help to make their holiday season brighter. Whether it's hanging stockings, buying goofy gifts or sharing family meals, it's the little details that make the holidays so wonderful. It's never too early to create magical memories with your little ones, so Disney Baby has put together some ideas for family traditions you can start today!
Find a fun way to prepare for the big day! Whether it's creating a homemade advent calendar filled with great goodies or reading holiday books like Christmas Around the World in the evenings before the main event, you and your little one can share in the gleeful anticipation of the holiday magic to come. We love creating a Christmas countdown. I remember doing this when I was little and love that my kids are doing it to. This helps them remember how many days left until Santa is coming to town.
Dedicate some family time to decorating your tree together. Give your little ones ornaments that are all their own, so they have special roles to play every year. You can also take this time to explain your family's history: try sharing stories about your favourite trimmings to show your wee one how special their contribution really is! We never really have a theme to our Christmas tree, I find it too stressful. Instead we have our ornaments that we've had for over ten years, along with customized ornaments for each member of our family and handmade ornaments that our kids have made over the years placed on our tree. It looks more and more beautiful each year.
Take a family photo to share on a card, or keep a special holiday album that will grow as your children do. To keep things interesting, try choosing a fun theme: you can all wear holiday PJs or goofy reindeer ears – coming up with a new one every year is a great way to share some cheer together. If it's your baby's first holiday, why not preserve the memory of your little elf in a customizable photo frame?
Disney Baby is offering one of Just Us Girls Canadian readers four pairs of cute, cozy and comfy Gortex socks, featuring your favourite Winnie the Pooh characters, and a Winnie the Pooh hand-print photo frame set. This prize back is valued at approx. $30.
What are some of your family traditions during the holidays? Do you bake sweet treats together? Listen to holiday music? We'd love to know, leave a comment below!


For your comfort ......... we have massage built right into your dental chair. We offer warm blankets and pillows, movies, televisions, lip balm, refreshments and WiFi for you to enjoy. Relax, sit back and let us spoil you!
Many people are afraid and uncomfortable going to the dentist. You are not alone. Dental fear is a very common fear. Dr. Hilton-Foley has had many years of experience helping those that are in need of dentistry, but are afraid to see the dentist. You'd be surprised to hear, most people have put off needed dentistry because of their fear. Because of our gentle touch and caring manner, in the majority of our cases, we are able to work with patients without the need for sedation, but we want you to know, it is available for you, if needed.
For those people that are simply too afraid to even start treatment, much less make and keep their appointment, we want you to know that you have the option available for oral sedation or anxiety medication to help you relax, both prior to your appointment, and on the day of your appointment. With sedation, you can have the work done that you need, and miraculously, have no memory of even going to your appointment! For people with dental fear, this is a welcomed thought!
Give us a call at 813-891-1212, and we'd be happy to talk to you.


text:
package com.treasuredata.jdbc;

import io.netty.channel.ChannelHandlerContext;
import io.netty.handler.codec.http.HttpRequest;
import org.junit.After;
import org.junit.Before;
import org.junit.Test;
import org.littleshoot.proxy.HttpFilters;
import org.littleshoot.proxy.HttpFiltersSourceAdapter;
import org.littleshoot.proxy.HttpProxyServer;
import org.littleshoot.proxy.ProxyAuthenticator;
import org.littleshoot.proxy.impl.DefaultHttpProxyServer;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;

import java.io.IOException;
import java.net.ServerSocket;
import java.sql.Connection;
import java.sql.ResultSet;
import java.sql.SQLException;
import java.sql.Statement;
import java.util.Properties;
import java.util.concurrent.atomic.AtomicInteger;

import static org.junit.Assert.assertEquals;
import static org.junit.Assert.assertTrue;
import static org.junit.Assert.fail;

/**
 *
 */
public class TestProxy
{
    private static Logger logger = LoggerFactory.getLogger(TestProxy.class);

    private HttpProxyServer proxyServer;
    private int proxyPort;

    private static int findAvailablePort()
            throws IOException
    {
        ServerSocket socket = new ServerSocket(0);
        try {
            int port = socket.getLocalPort();
            return port;
        }
        finally {
            socket.close();
        }
    }

    private static final String PROXY_USER = "test";
    private static final String PROXY_PASS = "helloproxy";

    private AtomicInteger proxyAccessCount = new AtomicInteger(0);

    @Before
    public void setUp()
            throws Exception
    {
        proxyAccessCount.set(0);
        this.proxyPort = findAvailablePort();
        this.proxyServer = DefaultHttpProxyServer.bootstrap().withPort(proxyPort).withProxyAuthenticator(new ProxyAuthenticator()
        {
            @Override
            public boolean authenticate(String user, String pass)
            {
                return user.equals(PROXY_USER) && pass.equals(PROXY_PASS);
            }
        }).withFiltersSource(new HttpFiltersSourceAdapter()
        {
            @Override
            public HttpFilters filterRequest(HttpRequest httpRequest, ChannelHandlerContext channelHandlerContext)
            {
                proxyAccessCount.incrementAndGet();
                return super.filterRequest(httpRequest, channelHandlerContext);
            }
        }).start();

        // Unset proxy configuration
        System.clearProperty("http.proxyHost");
        System.clearProperty("https.proxyHost");
        System.clearProperty("http.proxyPort");
        System.clearProperty("https.proxyPort");
        System.clearProperty("http.proxyUser");
        System.clearProperty("http.proxyPassword");
    }

    @After
    public void tearDown()
            throws Exception
    {
        if (this.proxyServer != null) {
            proxyServer.stop();
        }
    }

    // FIXME: td-client-java v0.5.10 has a bug that `http.proxyUser` isn't used for proxy authentication.
    //        https://github.com/treasure-data/td-client-java/blob/d61097d12af38eb3324f7fb80a7c72866ae71511/src/main/java/com/treasure_data/client/HttpConnectionImpl.java#L81-L82
    //        So, we skip these tests for now.
    // @Test
    public void connectThroughProxy()
            throws IOException, SQLException
    {
        Connection conn = TestProductionEnv.newConnection(String.format(
                "jdbc:td://api.treasuredata.com/sample_datasets;useSSL=true;type=presto;httpproxyhost=localhost;httpproxyport=%d;httpproxyuser=%s;httpproxypassword=%s",
                proxyPort,
                PROXY_USER,
                PROXY_PASS),
                new Properties()
        );
        Statement stat = conn.createStatement();
        stat.execute("select count(*) from www_access");
        ResultSet rs = stat.getResultSet();
        assertTrue(rs.next());
        int rowCount = rs.getInt(1);
        assertEquals(5000, rowCount);
        stat.close();
        conn.close();

        assertTrue("no proxy access", proxyAccessCount.get() > 0);
    }

    private static void assertFunction(Properties prop, String sqlProjection, String expectedAnswer)
            throws IOException, SQLException
    {
        Connection conn = TestProductionEnv.newPrestoConnection("sample_datasets", prop);
        Statement stat = conn.createStatement();
        String sql = String.format("select %s from www_access", sqlProjection);
        stat.execute(sql);
        ResultSet rs = stat.getResultSet();
        assert (rs.next());
        String col = rs.getString(1);
        logger.debug("result: " + col);
        rs.close();
        stat.close();
        conn.close();
    }

    private Properties getJdbcProxyConfig()
    {
        Properties prop = new Properties();
        prop.setProperty("httpproxyhost", "localhost");
        prop.setProperty("httpproxyport", Integer.toString(proxyPort));
        prop.setProperty("httpproxyuser", PROXY_USER);
        prop.setProperty("httpproxypassword", PROXY_PASS);
        return prop;
    }

    // @Test
    public void proxyConfigViaProperties()
            throws IOException, SQLException
    {
        assertFunction(getJdbcProxyConfig(), "count(*)", "10000");
        assertTrue("no proxy access", proxyAccessCount.get() > 0);
    }

    // @Test
    public void proxyConfigViaSystemProperties()
            throws IOException, SQLException
    {
        System.setProperty("http.proxyHost", "localhost");
        System.setProperty("http.proxyPort", Integer.toString(proxyPort));
        System.setProperty("http.proxyUser", PROXY_USER);
        System.setProperty("http.proxyPassword", PROXY_PASS);

        Properties emptyProp = new Properties();
        assertFunction(emptyProp, "count(*)", "5000");
        assertTrue("no proxy access", proxyAccessCount.get() > 0);
    }

    // @Test
    public void detectWrongProxyPassword()
            throws IOException, SQLException
    {
        Properties prop = getJdbcProxyConfig();
        prop.setProperty("httpproxyuser", "testtest"); // set a wrong password
        System.setProperty("td.client.retry.count", "2"); // For workaround of #1
        Statement stat;
        try {
            Connection conn = TestProductionEnv.newPrestoConnection("sample_datasets", prop);
            stat = conn.createStatement();
            stat.execute("select count(*) from www_access");
        }
        catch (SQLException e) {
            // Should display authentication failure message here
            logger.error("authentication failure", e);
            return;
        }
        ResultSet rs = stat.getResultSet();
        rs.next();
        int result = rs.getInt(1);
        logger.debug("result: " + result);
        fail("should not reach here");
    }
}


The undersigned hereby authorizes the above-named insurance company to pay Cranston Collision Center directly for all repairs and supplement invoices for the above-mentioned vehicle/claim. Please note: Payment must first be received in full prior to deliver of the vehicle. Any payment inadvertently sent to the insured must be forwarded to Cranston Collision Center immediately upon receipt. In addition, the undersigned authorizes Cranston Collision Center to sign their name to the insurance check for repairs that have been completed to this vehicle.
The undersigned hereby acknowledges receipt and acceptance of said Direction to Payment. Please note: Any company not honoring the Direction to Pay accepts responsibility for delay in delivery of said vehicle until payment of all work orders and supplements have been paid in full.


Visit this page for an ever expanding list of resources from your pastoral staff.
J.R. Miller's Family Prayers This faithful pastor wrote extensively on the home and family worship. These prayers are a great primer to praying as a family.
My Utmost for His Highest Oswald Chambers' classic daily devotion.
Pastor Well Dr. York's online home for blogging, articles, teaching, and sermons.
Center for Parent/Youth Understanding Get to know your culture. Communicate with your child.
Plugged In This ministry of Focus on the Family gives you a Christian review on current entertainment.
The Gospel Coalition Top evangelical scholars and pastors apply the gospel to the current culture.
Albert Mohler The President of SBTS provides essays on culture and a daily digest of news from a Christian worldview.
Thom Rainer The CEO of LifeWay Christian Resources, Dr. Rainer writes on church health and leadership.


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The Big Bang Theory: Renewed Through Season 10 by CBS
It's a good day for the geeks. CBS has announced that they've renewed The Big Bang Theory for three more years (seasons eight, nine and 10) which will keep it on the air through the 2016-17 season.
CBS ANNOUNCES MULTI-YEAR BROADCAST AGREEMENT FOR "The Big Bang Theory"
Deal Extends Television's #1 Comedy Through the 2016-2017 Season
CBS announced today a multi-year broadcast renewal for the top-rated, critically acclaimed comedy The Big Bang Theory.
The Big Bang Theory, which is TV's most-watched comedy and the top-rated broadcast entertainment show among adults 18-49, has been renewed for an additional three years, extending it through the 2016-2017 season.
"Comedy is a big part of our schedule, and The Big Bang Theory is the biggest comedy force on television," said Nina Tassler, Chairman, CBS Entertainment. "This multi-year deal further strengthens our network's position for future seasons and marks another chapter in the great partnership CBS enjoys with Warner Bros. Television for delivering audiences the best in comedy. We're proud to work with and showcase the incredible talents of Chuck Lorre, Steve Molaro and this amazing cast every week."
About The Big Bang Theory:
The Big Bang Theory, which premiered in September 2007, has been television's #1 comedy in viewers since 2010-2011 and continues as the #1 comedy in key demographics for the second straight season. This season, THE Big Bang Theory is averaging 19.79 million viewers (+4% versus last year), 6.1/19 in adults 18-49, 7.8/21 in adults 25-54 and 4.5/16 in adults 18-34, ranking as the highest-rated non-sports program in all these demographics.
In addition to being a ratings success, The Big Bang Theory has earned critical acclaim and award recognition. The series has won Emmy Awards for "Outstanding Lead Actor in a Comedy Series" for star Jim Parsons (2010, 2011, 2013), a People's Choice Award for "Favorite TV Comedy" (2010, 2013, 2014), Television Critics Association Awards for "Outstanding Achievement in Comedy" (2009, 2013) as well as "Individual Achievement in Comedy" for Parsons (2009). In 2011, Parsons won a Golden Globe for "Best Actor in a Television Series Musical or Comedy" while Kaley Cuoco-Sweeting also won a 2014 People's Choice Award for "Favorite Comedic Actress."
The Big Bang Theory stars Johnny Galecki, Jim Parsons, Kaley Cuoco-Sweeting, Simon Helberg, Kunal Nayyar, Mayim Bialik and Melissa Rauch. Chuck Lorre, Steve Molaro and Bill Prady are executive producers. The series is from Chuck Lorre Productions, Inc., in association with Warner Bros. Television. Chuck Lorre and Bill Prady are series creators.
More about: The Big Bang Theory, The Big Bang Theory: canceled or renewed?, The Big Bang Theory: ratings
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The Big Bang Theory: Retrospective Special to Follow CBS Series Finale
The Big Bang Theory: Ending in 2019; No Season 13 for CBS Comedy Series
The Big Bang Theory: CBS Hopeful for Season 13
The Big Bang Theory: Is the CBS Sitcom Ending? It's "One Episode at a Time"
The Big Bang Theory: Season 11; Showrunner Change Due to Young Sheldon
The Big Bang Theory: Renewed for Season 11 & Season 12 on CBS
Young Sheldon: CBS Orders Big Bang Theory Prequel for 2017-18
The Big Bang Theory: Young Sheldon & Mom Cast for Prequel Pilot
The Big Bang Theory: Seasons 11 & 12 Renewals in the Works
The Big Bang Theory: Jim Parsons Would Be Shocked If There's No Season 11
The Big Bang Theory: CBS Considering Young Sheldon Spin-off Series
The Big Bang Theory: Star Foresees Many More Seasons
The Big Bang Theory: No Season 11 for Top CBS Sitcom?
The Big Bang Theory: CBS Sitcom Renewed for Three Seasons, Through 2013-14
Two and a Half Men and The Big Bang Theory: CBS Sitcoms Renewed
Renew, Renew, Renew!!!! Please.
Much as I like the show, this might be stretching it unless they have some more surprises in store. Penny and Leonard getting married will do for a season or two (maybe a baby Wolowitz family), but with Sheldon dealing with the impending marriage, it might start to go downhill.
I am happy that "The Big Bang Theory" has been given another three seasons, I hope it gets a 12th season!
Rhoda, "Fringe" was on FOX not CBS. "The Big Bang Theory" is in syndication and a lot of FOX stations do air the syndicated repeats but it still airs new episodes on CBS.
No-brainer. But those kids are getting long in the tooth. How long can they last? Get the series on Hulu please.
Well, you all did something good for a change. I would be happier if you would bring 'Fringe' back. I will never let up on that.


Are Boston couples who share housework more likely to divorce?
On behalf of Kajko, Weisman & Colasanti, LLP posted in Divorce on Wednesday, October 17, 2012.
It may not be the first logical conclusion many Bostonians come to, but a recent study conducted in Norway found that men and women who shared traditional household responsibilities were more likely to divorce than couples in which women did the majority of the housework.
"The more a man does in the home, the higher the divorce rate," said the author of the study. But the increased divorce rate probably isn't caused by the fact that certain men do more or less chores than others; it may be a symptom of what the author called "modern" couples and their relationships.
"In these modern couples, women also have a high level of education and a well-paid job, which makes them less dependent on their spouse financially," the author reasoned. He also noted that professional couples were more likely to have an organized, contractual-based marriage, where roles and responsibilities are well defined. "The more you organize your relationship, the more you work out diaries and schedules, the more it becomes a business relationship than an intimate, loving spontaneous one," claims the author.
This is an interesting study, and one that may surprise many, but it probably shouldn't raise any red flags amongst couples who split housework. In fact, a separate study showed that men who took on more domestic responsibilities felt more fulfillment and a better balance between life and work.
This study does not mean that women should go back to more traditional child rearing and house cleaning roles in the interest of preserving a marriage, and doing so would certainly provide no guarantee of personal happiness for a married couple.
Regardless of the division of responsibility in a marriage, the fact remains that many relationships will end in divorce. When chore division is not the key to preserving a marriage, an experienced family law attorney can help ensure that fair property division and child custody arrangements properly recognize individual contributions to a marriage.


It's NaNoWriMo! – Try something, even if it's scary.
I'm a little late in the day with writing this post, but it's getting done. Which is what National Novel Writing Month, AKA NaNoWriMo, is all about! Powering through it when it's the end of the day and you're tired but you still have work (writing) to do. Huzzah!
Here's a Writer's Wednesday shout-out to all writers participating in this year's event. Good luck and God speed to all of you. May the fingers fly over the keyboards and the words multiply like magic on the computer screen. And, of course, may the force be with you!
Thanks for the thoughts! I hope your writing is coming along as well!


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Grading NAFTA: A year on
Colin Robertson August 18, 2018 August 26, 2018 Comments Off on Grading NAFTA: A year on
Grading Canada on NAFTA: Experts weigh in, one year later
Nicole Gibillini, BNN Bloomberg August 18,2018
One year ago, trade representatives from Mexico, Canada, and the United States kicked off renegotiations for the North American Free Trade Agreement Washington, D.C., with a goal of clinching an agreement by early 2018.
While some progress has been made, a deal still hasn't been reached. Autos and the U.S. demand for a sunset clause have been key sticking points. Meanwhile, Canada has become one of Donald Trump's main targets in recent weeks with the U.S. president threatening more tariffs on Canadian car imports if a deal isn't struck.
Below, four experts weigh in on Canada's progress in the talks so far and offer their view on what needs to happen next.
What's ahead for NAFTA as U.S. and Mexico meet again without Canada
Colin Robertson, VP and fellow at the Canadian Global Affairs Institute and member of the team that negotiated the original NAFTA deal, joins BNN Bloomberg to provide perspective on what's ahead in NAFTA 2.0 negotiations, as the U.S. and Mexico meet.
COLIN ROBERTSON, VP AND FELLOW, CANADIAN GLOBAL AFFAIRS INSTITUTE
Grade: A, for exhibiting Hemingway's definition of courage: "grace under pressure"
What has been the biggest hurdle for Canada so far?
"Donald Trump. Does he want a NAFTA or not? Is the administration prepared to negotiate on the remaining critical issues: dispute settlement (chapters 11, 19, 20) and government procurement?"
What has been Canada's biggest success?
"We are still in negotiation and the Canada-Mexico partnership remains solid."
What has been the biggest disappointment?
"U.S. intransigence and the sense that their negotiating team is awaiting instructions on their mandate and scope for negotiation."
What is the most important thing Canada needs to do going forward?
"Keep negotiating and trying to make progress on the issues. Keep in mind the average negotiation for a deal of this size even renegotiated is three-to-five years. We are actually making reasonable progress given the complexities involved. Granted, a lot of what is being negotiated was already negotiated by the U.S., Canada and Mexico in the TPP and many of the negotiators are the same. So there is familiarity with the issues and one another."
What has been the biggest surprise throughout the negotiations?
"Donald Trump's personal involvement. He has so much policy ground to choose from but he has made NAFTA a personal interest as we have learned to our surprise and disappointment in his tweets."
Ottawa mulling steel safeguards: Is this a wise move?
Maryscott Greenwood, CEO of the Canadian American Business Council, joins BNN Bloomberg to discuss Ottawa's decision to launch consultations with the aim of protecting Canada's steel industry, and what's ahead for NAFTA.
MARYSCOTT GREENWOOD, CEO, CANADIAN AMERICAN BUSINESS COUNCIL
Grade: I for incomplete
"I would say the unpredictability of the U.S."
"Raising awareness in the U.S. and Canada of the importance of our economic relationship."
"Not getting a deal done yet."
"Canada needs to come to the table with practical deals in mind. Focus on the practicality as opposed to the principle."
"The fact that [Andres Manuel Lopez Obrador], the new president of Mexico, has been eager to conclude a modernized NAFTA before he takes office on Dec. 1."
Trump's focus on tariffs still truly remain China: Trade expert
Christopher Sands, director of the Center for Canadian Studies at Johns Hopkins University, joins BNN Bloomberg's Catherine Murray for a look at the growing ripple effects from Trump's tariffs.
CHRISTOPHER SANDS, DIRECTOR, CENTER FOR CANADIAN STUDIES, JOHN HOPKINS UNIVERSITY
"Overcoming an initial impression (given by President Trump) that the renegotiation of NAFTA would involve only 'tweaks' with regard to Canada-U.S. trade arrangements. This led Canada to play it safe with a defensive strategy that was hard to abandon when the gravity of the talks became more apparent (lots of clues are visible in retrospect)."
"Mobilizing an impressive outreach to the Congress, state governors and legislators on the benefits to the United States of trade with Canada … Combined with a thoughtful outreach to the Trump administration, including White House staff and cabinet departments, the Canadian effort was more extensive that any that a foreign country has ever mounted in the United States."
"It would be a tie for me. First, the failure of the impressive Canadian outreach to garner a single concession from the United States – not on softwood lumber, not on gypsum – which was then followed by the self-destructive Canadian attack on U.S. trade remedy practices now pending before the World Trade Organization, a clear sign of Canadian frustration.
"Second, the business community in both Canada and the United States has been far less effective at defending the integrated continental supply chains that link the three NAFTA economies. Why? I still don't really know."
"Heal the breach with the Trump White House."
"Almost all of the things I have mentioned above surprised me, but the suspension of the NAFTA talks in June followed by their resumption on a bilateral basis by the U.S. and Mexico was the biggest surprise."
Trump playing 'old-fashioned leverage' with Canada freeze-out: Trade lawyer
Mark Warner, principal at MAAW Law, joins BNN Bloomberg to provide perspective on Trump's latest tweet on NAFTA, in which he essentially says he's freezing Canada out of talks.
MARK WARNER, PRINCIPAL, MAAW LAW
Grade: A+ for effort in engaging with key stakeholders, B+ overall
"The biggest hurdle for Canada in the NAFTA negotiations so far has been in grappling with the scope of the Trump administration's demands to roll back some of the perceived gains from NAFTA in the area of dispute settlement (and demand for a sunset clause) and to deal with traditional U.S. demands for concessions in areas like supply management for the price of maintaining NAFTA rather than for new U.S. concessions."
"The biggest success for Canada has been to keep drawing out the negotiations without Trump triggering a notice of withdrawal to Canada and Mexico. That said, the price of doing so has been increased investment uncertainty and the strategy has led Trump to seek other opportunities for leverage in the negotiations outside NAFTA, most notably in Canada's inclusion in the Section 232 national security tariffs on steel and aluminum and threatened ones on autos."
"The biggest disappointment is that Canada has adopted a passive, defensive approach to the NAFTA renegotiation with engagement mostly with U.S. stakeholders rather than proactively engaging stakeholders in Canada for self-interested policy or market access concessions that could be offered up to move Canada out of Trump's attention (e.g. supply management)."
"The most important thing Canada needs to do right now is to find something to offer in the NAFTA negotiations to avoid Trump imposing Section 232 national security tariffs on exports of autos and auto parts from Canada. And to end the spiral of 'tit for tat' tariff retaliation, which is a game that ultimately Canada cannot win because of the asymmetries in the size of the two economies and relative importance of bilateral trade to each country."
"The biggest surprise to me is that Canada and Mexico have managed to hang together, at least publicly, until recently, although I wonder whether the time horizons of the newly-elected Mexican president and the Canadian prime minister approaching his re-election year will stay aligned if the NAFTA negotiations continue."
Newspaper Bloomberg, NAFTA, Nicole Gibillini


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Goose The Cat leads new 'Captain Marvel' character posters
Matthew Escosia Jan 22, 2019
New character posters abound for the upcoming 'Captain Marvel' movie, providing individual looks for every characters.
The pleasant surprise here is the one with Goose, the feline character that accompanies the titular character and Samuel L. Jackson's Nick Fury in their adventures.
Set in the 1990s, Marvel Studios' "Captain Marvel" is an all-new adventure from a previously unseen period in the history of the Marvel Cinematic Universe that follows the journey of Carol Danvers as she becomes one of the universe's most powerful heroes. While a galactic war between two alien races reaches Earth, Danvers finds herself and a small cadre of allies at the center of the maelstrom.
"Captain Marvel" opens in Philippine cinemas on March 6, 2019.
Captain Marvel FEATURED UPDATES


When you are grounded, you have the ability to overcome any obstacle with grace. Who would you be if you were not limited by your fears? The Grounding mala can remind you that it is always safe for you to tap into your personal power + let your authentic self shine. Feel at home in yourself, find peace in knowing that you are supported, safe and most importantly, strong.
The Grounding Mala features smokey quartz, pink opal and white jade. Allow it to bring out the best in you, because your love, determination and the strength of your spirit all flow from your connection to the earth.


There are currently 4 Homes for sale in Cedar Ridge. The average price for Cedar Ridge properties is $200,575which is 49% lower than all Homes within a 20 mile radius. The highest priced property in Cedar Ridge is $208,500 while the lowest priced Home is listed at $190,000. Most of the properties available in Cedar Ridge are Homes . Compared to last month, the average price of real estate in the area has gone up 100%.


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MARCUS COLUMN: Three facts about Indiana's economy
Jeffersonville, IN (47130)
Variable clouds with snow showers or flurries. Some mixed winter precipitation possible. Low 23F. Winds N at 5 to 10 mph. Chance of snow 60%. Snow accumulations less than one inch..
Variable clouds with snow showers or flurries. Some mixed winter precipitation possible. Low 23F. Winds N at 5 to 10 mph. Chance of snow 60%. Snow accumulations less than one inch.
Floyd Central Theatre Arts receives statewide honors
It's all in a cold day's work for ISP
Amid low rankings, Indiana eyes $240M increase …
Jeffersonville furniture bank helps people get …
Morton J. Marcus
MORTON MARCUS Eye on the Pie
How far back should we look to evaluate where we have been and where we are going? What factors should we consider? The wise analyst/consultant picks that period of time and those factors which makes the folks paying the bill happiest.
Since this column won't pay me enough to buy a breaded tenderloin sandwich, I'll pick what I think is most helpful for all of us to know.
The average wage per job in Indiana paid $64,909, 21st in the nation in 2021. (These data from the U.S. Bureau of Economic Analysis don't provide the median – for those who read last week's column.). That puts Indiana $6,108 below the national average.
Over the past decade, without adjustment for inflation, the average Hoosier wage grew by 3%, the 17th highest in the U.S. But we don't live in the present alone. We carry the past with us.
Over the 50 years from 1971 to 2021, our average rate of growth in wages ranked 36th among the 50 states. In 1971, Indiana's average wage was 2.6% below the national average; in 2021 Indiana was 8.6% short of the national average pay.
(Please don't start that dribble about our low cost of living; wages determine housing prices which are the biggest factor in the cost of living.)
Wages, salaries, and bonuses are forms of compensation. Without adjustment for inflation in the past 24 years, compensation of Hoosiers grew annually by 3.4% compared to 4.2% for the nation. The result: Indiana workers went from 2.1% of total compensation nationally in 1997 to 1.7% in 2021.
Compensation of workers is the biggest piece of Gross Domestic Product (GDP). In 1997, Hoosier workers got 57.5% of the state's GDP; in 2021 it was 52.5%. That five percentage point decrease was greater than the nation's 1.1 point drop.
Workers in 2021 got a smaller part of the value of the goods and services they provide than they did in 1997. And it was worse in Indiana than nationally.
For Hoosiers it's been a double whammy. A smaller share of GDP and a slower rate of GDP growth in Indiana (3.8% annual average) than in the nation as a whole (4.2%).
There you have three facts: Although 1) Indiana recently is doing better than in the past quarter century in average wages, 2) the weight of deficient GDP growth, and 3) a declining share of compensation from GDP, presses down on the economic opportunities for Hoosiers.
Our problems will not be resolved by competing with Asian companies, but by out-performing companies in the U.S. and Europe who produce more distinctive products and services. Computer chips, like corn chips, are just commodities.
Our investments should advance innovative economic resources — – such as educated children and adults.
Mr. Marcus is an economist. Reach him at mortonjmarcus@yahoo.com. Follow him and John Guy on Who Gets What? wherever podcasts are available or at mortonjohn.libsyn.com
Read current and past editions of the News and Tribune's bimonthly business magazine.
TUCKER, Barry Jan 15, 1955 - Jan 29, 2023
HAMM, Robert Nov 2, 1946 - Jan 28, 2023
FOREMAN, Sharon Apr 9, 1944 - Jan 28, 2023
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Overton, Lucille
Greenville's Stevie Griffin crowned Miss Indiana Volunteer
Jeffersonville furniture bank helps people get back on their feet
First public meeting about Jeffboat site's future standing-room-only
GIRLS' BASKETBALL: Freshmen having big impact
BOYS' BASKETBALL ROUNDUP: Dragons can't overcome Benter's enormous night
Jeffersonville man facing numerous drug charges
Costumes from Charlestown to the Oscars
OUR VIEW: Library should provide longer notice period
Greater Clark names future elementary schools in Jeffersonville, Charlestown
Academic honors for area students
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Bocci Shoes was founded in 1926 in the heart of Italy, the Marches, where the footwear industry has its roots more deep. With the succession of four generations in the market has always together tradition and innovation: for that accompanies the already wide variety of models in shoes, clothing and a wide range accessories.
The online presence for over five years offers the same service offered in stores located throughout the territory of Marche, a widening of the offer to all Internet users.
For any contact please see CONTACTS.


Hello my name is Brandon. I just moved to a big city, from a small rural town. I don't know a lot of people here. I'm looking for pen-pals for snail mail. I like anime, video games, and animals. I work with horses. I'm going to start school to be a vet soon. I get along with just about everyone. So feel free to send me a email.
Very calm and simple person who wants to make good friends around the world to share difference of culture and more interesting things.
I am Isaac from Canada, lookin for email friends only all race are welcome my repply's very soon looking forward to hear from you.
am here looking for pen pal, friendship, activity partner, true love, ok I know all but the first thing sounds completely ridiculous, anyway don't know what else to say then well it be nice having a pen pal someone to communicate on a regular basis with, I know I don't belong here am just a lonely unhappy person(not crazy nor psychotic nothing like that) unhappy cause well its a long story has something to do with being disabled and was put here for others amusement ill stop before I ramble on too much might have already said too much am sorry about that am seriously messed up from being bullied all my life all I have to say about that.


Wondering if anyone has come across this. A station that uses our service gets this every now and then (usually specific DJ connections, When this happens, there are times the connection for drops. Might anyone know what is causing this?
what version of sc_serv2 do you use?