text:
De Châtel Rudolf (Budapest, 1938. július 9. – Budapest, 2014. június 12.) magyar kutató orvos, belgyógyász, nefrológus, az orvostudományok doktora. Kutatási területe a belgyógyászaton belül a nátrium-anyagcsere jellemzői és a vérnyomás viszonya. A hipertónia neves kutatója. 1991 és 1997 között a Semmelweis Orvostudományi Egyetem Általános Orvostudományi Kar dékánja. 1993 és 2003 között az I. számú Belgyógyászati Klinika igazgatója. Felesége volt Gyöngyössy Katalin színésznő.

Életpályája

Német és francia elődökkel rendelkező család sarjaként született. Édesanyja holland, édesapja de Châtel Andor reumatológus volt. Testvérei, de Châtel Péter fizikus és Krisztina koreográfus Hollandiában élnek. Középiskolai tanulmányait a budapesti József Attila Gimnáziumban végezte, ahol 1956-ban érettségizett. Ezután felvették a Budapesti Orvostudományi Egyetemre, ahol 1962-ben szerzett orvosi doktorátust. Diplomájának megszerzését követően az egyetem Élettani Intézetében kapott állást. 1969-ben átkerült Magyar Imre javaslatára az I. számú Belgyógyászati Klinikára. 1973-ban osztályvezető orvossá nevezték ki, a nefrológia-hipertónia szakrendelés vezetője lett. Emellett az egyetemen is tanított, 1991-ben kapta meg egyetemi tanári kinevezését. Ugyanebben az évben az egyetem Általános Orvostudományi Karának dékánjává választották, ebben a pozíciójában 1994-ben megerősítették. A kart 1997-ig vezette. Eközben 1993-ban a klinika igazgatója is lett, amit tíz éven keresztül vezetett. 2008-ban emeritálták. Magyarországi munkája mellett 1974–1975-ben Bernben volt vendégkutató.

1978-ban védte meg az orvostudomány kandidátusi, 1991-ben akadémiai doktori értekezését. Az MTA Klinikai Tudományos Bizottságának lett tagja. 1994 és 2000 között a Magyar Tudományos Akadémia Közgyűlésének doktori képviselője volt. 1989 és 1996 között a Magyar Orvosi Kamara nemzetközi bizottságának elnöke, 1992 és 1996 között a Magyar Ösztöndíj Bizottság tagja volt. Ezenkívül 1989 és 1995 között a Magyar Belgyógyász Társaság főtitkára is volt, majd megválasztották a társaság elnökévé. 1994 és 1998 között a Korányi Társaságot is vezette, valamint 1994 és 2000 között a Magyar Hipertónia Társaság alelnökeként is tevékenykedett. 2001 és 2010 között a társaság elnöke volt. 1993-tól az Orvostovábbképző Szemle című tudományos folyóirat szerkesztőbizottságának elnöke. Ugyanebben az évben a salzburgi Európai Tudományos és Művészeti Akadémia tagjává választotta.

Családja
A felesége volt Gyöngyössy Katalin színésznő, akitől született a lánya, de Châtel Andrea.

Díjai, elismerései

Gömöri Pál-emlékérem (1992)
Akadémiai Díj (1994)
Szent-Györgyi Albert-díj (1997)
A Magyar Köztársasági Érdemrend lovagkeresztje (2003)
A Magyar Érdemrend középkeresztje (2014)

Főbb publikációi

The effect of isopropyl-noradrenaline on renal haemodynamics (társszerző, 1968)
Interrelations between blood pressure, blood volume, plasma renin and urinary catecholamines during beta-blockade in essential hypertension (társszerző, 1976)
Sodium, renin, aldosterone, catecholamines, and blood pressure in diabetes mellitus (első szerző, 1977)
Alpha and beta adrenergic blockade with orally administered labetalol in hypertension. Studies on blood volume, plasma renin and aldosterone and catecholamine excretion (társszerző, 1978)
Hipertónia (első kiadás 1983)
Exchangeable body sodium: its relationship with blood pressure and atrial natriuretic factor in patients with Diabetes Mellitus (első szerző, 1986)
Atrial natriuretic peptide (ANP) in patients with chronic renal failure on maintenance haemodialysis (első szerző, 1991)
Gyógyszeres terápia (szerk., 1993)
Nephrologia (szerk., 1994)
Production of ouabain by rat adrenocortical cells (társszerző, 1996)
Interactions between ouabain atrial natriuretic peptide, angiotensin-II and potassium: Effects on rat zona glomerulosa aldosterone production (társszerző, 1998)
p53 mutations in hairy cell leukemia (társszerző, 2000)
Circulating and cardiac levels of apelin, the novel ligand of the orphan receptor APJ, in patients with heart failure (társszerző, 2003)
The effects of strontium ranelate on the risk of vertebral fracture in women with postmenopausal osteoporosis (társszerző, 2004)
Az "Éljen 1140/90 alatt" program kardiovastkuláris kockázatcsökkentő eredményei - 2005-2011 (társszerző, 2012)

Jegyzetek

Források

2009-es interjú a HVG egészségügyi magazinjában
Publikációs lista a Magyar Tudományos Művek Tárában

Magyar orvosok
Magyar belgyógyászok
Nefrológusok
Magyar egyetemi, főiskolai oktatók
Magyar professor emeritusok
Szent-Györgyi Albert-díjasok
Akadémiai díjasok
1938-ban született személyek
2014-ben elhunyt személyek
Budapesten született személyek

redpajama_set_name: RedPajamaWikipedia


Hi, I found your poly tunnel layout really interesting. I'm not sure how old it is.Can you please tell me if you made holes in the black plastic inside the raised beds.Might sound a bit of a dumb question but need to be sure.Many thanks Janice.
I'm sure you can find similar elsewhere though. We now have covered the paths with wood chip and have re-skinned the poly tunnel after the old one fell apart.
Thanks very much.I know the product that lets the water through, but from your picture it looks as if you've used black plastic inside the raised beds and the green product which lets the water through elsewhere.


His glance at Rachel now became inquisitive, calculating, It seemed to be saying: "One day I may be able to make use of this piece of goods." But there was a certain careless good-humour in it, too. What he saw was a naïve young maid, with agreeable features, and a fine, fresh complexion, and rather reddish hair. Yes, he liked to see her timid and downcast before him.
He appears somewhat downcast, or rather, I should say, has a melancholy cast of countenance: he is advanced in years, with a profusion of hair around his face, chin and throat is apparently between sixty and seventy years of age. I requested him to enroll his name in my autograph-book, which he did with readiness. He remarked that he was often requested to do so, especially by the ladies.
"There was a pair of antlers," he muttered. "They might go in my collection. You will want to sell them." The downcast eyes did not leave the floor. "They are sold," she said, "to Herr Umstätter." A little smile played about the thin lips. "Sold! Already!" The round eyes bulged at her. "My God!" he shouted fiercely, "you would sell his very soul, if he had left it where you could!"
I walked with downcast head, without thought, almost without sensation, but utterly buried in myself. A rhythmic hollow and angry noise raised me from my numbness. I lifted my head; it was the sea roaring and moaning fifty paces from me. I saw I was walking along the sand of the dunes.
The very way he stood, so quiet, so insidious, like an erect, supple symbol of life, the living body, confronting her downcast soul, was torture to her. He was like a supple living idol moving before her eyes, and she felt if she watched him she was damned. And he came and made himself at home in her little home.
Of Artie Brower and the Morgan stallion we found hardly a trace. They had been literally blown to pieces. Not one of us who had known him but felt in his heart a kindly sorrow for the strange little man. The sentry who had fired at him and who had thus, indirectly, precipitated the catastrophe, was especially downcast.
Moretti had stood immovable during this speech, his dark face rigid, his eyes downcast, listening to every word, but now he raised his hand with an authoritative gesture. "Enough!" he said, "I will hear no more! You know the consequences of this at the Vatican?" "I do." "You are prepared to accept them?"
I wonder what the women would say, if they saw the dashing Edward Pepper, Esquire, walking arm in arm with thee at Ranelagh or Vauxhall! Nay, man, never be downcast; if I laugh at thee, it is only to make thee look a little merrier thyself. Why, thou lookest like a book of my grandfather's called Burton's ''Anatomy of Melancholy; and faith, a shabbier bound copy of it I never saw."
It hurls armies over the map of Europe of initiative and devotion in the common soldier, who in the Latin conception of the word remains a human being with a soul. An officer remarked to me, "We cannot have our men come from the trenches glum and downcast a Frenchman must laugh and joke or something is wrong with him. So we started these vaudevilles behind the lines, and sports."
"The priest is right, Amine," said Philip sitting down by her. "This cannot last; would that I could ever stay with you; how hard a fate is mine! You know I love the very ground you tread upon, yet I dare not ask thee to wed to misery." "To wed with thee would not be wedding misery, Philip," replied Amine, with downcast eyes. "'Twere not kindness on my part, Amine. I should indeed be selfish."


text:
package accessor

import (
	"testing"
)

func s3Accessor() KevValueAccessor {
	return &S3Accessor{
		testingBucketName: "weagle-sparta-testbucket",
	}
}

func TestS3PutObject(t *testing.T) {
	testPut(t, s3Accessor())
}

func TestS3PutAllObject(t *testing.T) {
	testPutAll(t, s3Accessor())
}

redpajama_set_name: RedPajamaGithub


This is a placeholder page for Rose Baker, which means this person is not currently on this site. We do suggest using the tools below to find Rose Baker.
You are visiting the placeholder page for Rose Baker. This page is here because someone used our placeholder utility to look for Rose Baker. We created this page automatically in hopes Rose Baker would find it. If you are not Rose Baker, but are an alumni of Clearwater High School Clearwater, FL, register on this site for free now.


Home News traffics wishes you merry Christmas and a good start into the new year!
The year is near the end and Christmas is right around the corner. The whole tourism industry looks back on a year that was difficult because of many different events. Nevertheless, we conquered this year together amazingly.
Let's make travelling possible in 2017, as well, and fulfill people's wishes, because to travel is to live!
We want to thank you for your cooperation in 2016 and are looking forward to a successful year 2017.
We wish you and your family a merry Christmas from the bottom of our hearts.
To make the wait until Christmas a bit easier, we came up with something special this year.
Find our CosmoNauti in our look-and-find picture!


The perfect new gTLD for companies in the coffee business.
It's no surprise that coffee is one of the most consumed beverages in the world. Each year coffee companies spend millions of dollars creating product, and consumers spend billions embibing coffee drinks and coffee flavored goodies. Not to mention the the technology and machinery behind the wonderful treats baristas serve up every day. The new .coffee gTLD extension is ideal for companies in the coffee business! Whether you own/operate a coffee shop, are a coffee paraphernalia retailer, manufacturer barista machines, or you are involved in import/export/roasting of coffee beans, registering a .coffee domain extension for your brand will help you grow your business, by letting your customers and prospects know exactly who you are and what you do. And it will help boost advertizing and help you promote your business (or yourself) more effectively online, increasing search rankings for your business. Be sure to get the .coffee domain name you want before it's taken.
Why should I register a .Coffee domain name(s)?
If your business would benefit from having a domain name with the .TLD extension—if you want to grow and/or protect your brand(s) within this specific market, registering additional domain names, specifically new gTLDs, is the best way to optimize your naming strategy. This extension is great for companies in the coffee business... retailers, importers, manufacturers, and shop owners alike. Registering a .TLD domain name will boost advertizing and help you promote your business more effectively, increasing search ranking and relevance of your brand!
Who can register a .Coffee domain name?
How long does it take to register a .Coffee domain name?
This may depend on what phase of the launch we are in, but during General Availability .Coffee registrations should take no more than 24 hours.
What are the valid characters and length requirements for .Coffee domain names?
Can Safenames host my .Coffee domain name?
How do I transfer my .Coffee domain name?
Can I hide my .Coffee registration information?
Which registry manages the .Coffee domain extension?
What is the dispute policy for .Coffee domain names?


Tired of dealing with wires? Don't like being tethered? With the introduction of our new 100% wireless airLUX™ LED Headlight System it is time we talk about the benefits of "cutting the cord".
This HL360™ compatible battery is the most compact and lightweight battery of it's kind on the market to date with a weight of only 17g. That is about the same weight as a compact disc (CD). Utilizing the aforementioned award-winning HL360™ LED Headlight which attaches directly to the airLUX™ makes for the most iconic duo since PB & J. Providing 3.5 hours of battery life and an output of 21,000 Lux, putting the "LUX" into airLUX™.
Easy to use on/off touch control which even works through gloves and clothes, so there is no need to worry about degloving for use. Simply give it a tap to power on and off at your discretion. You might be thinking "It can't get any better than that" but it can. Charging the airLUX™ is as easy as charging your phone with the use of our Micro USB Charger.
In summary the airLUX™ is so light that you will barely notice you're wearing it, you don't have to worry about any loose wires or snagging because it is 100% wireless, it's easy to use, it can be charged anywhere with the use of a Micro USB, and it is made to complement the DentalTown Townie Choice Award-Winning Best LED Headlight of 2018.


Payments Afrika focuses on the continuing evolution and innovation of payments in Africa and abroad. We bring you the latest news around a wide range of electronic payments including card payments, ATMs, online payments, ecommerce, mobile payments, online banking, alternative payments, security and point of sale technology. Payments Afrika delivers up to date developments in payments, banking and technology that enable cutting-edge decision making for new opportunities, partnerships, market trends, sales leads and growth strategies.


text:
US, EU, Japan take on China over rare earths
The US, Europe and Japan have joined forces to challenge China's restrictions on exports of rare-earth metals, escalating a trade row over access to some of the most important raw materials used in advanced technologies.
In a formal complaint to the World Trade Organisation (WTO), the three trade powers accused Beijing of trying to hold down prices for its domestic manufacturers and to pressure international firms to move operations to China.
"We want our companies building those products right here in America. But to do that, American manufacturers need to have access to rare earth materials which China supplies," US President Barack Obama said at the White House.
Europe's trade chief said China's restrictions violated international trade rules and had to be removed.
"These measures hurt our producers and consumers in the EU and across the world, including manufacturers of pioneering hi-tech and 'green' business applications," said European Union Trade Commissioner Karel De Gucht.
Rare earths are crucial for the defence, electronics and renewable-energy industries and are used in a range of products such as the iPhone, disk drives and wind turbines.
Rash and unfair
Chinese state media described the trade complaint on Wednesday as rash and unfair.
"The accusations, which stress that China's rare earth policies have restricted global supplies, can hardly hold up, with demand only filling around half the export quotas last year," said state news agency Xinhua whose commentaries are generally seen as reflecting official views.
Beijing set an export quota of 30 258 tonnes in 2011 but it exported only 16 861 tonnes over the year, according to official customs data.
Industry executives said the fourfold increase in export prices over the past two years had encouraged buyers not only to relocate their operations to China, but also to develop alternative non-rare earth technologies.
As prices began to decline in the second half of last year, China also sought to reduce supplies further, launching a crackdown in August to force domestic producers to shut down until they were proven to be compliant with state output quotas, industry consolidation plans and new environmental regulations.
China has said its export curbs are needed to control environmental problems caused by rare earths mining and refining, and to preserve supplies of an exhaustible natural resource. Refining rare earths requires large amounts of acid and produces low-level radioactive waste.
The high price of rare earth
Earlier on Tuesday, China's Minister of Industry and Information Technology Miao Wei said China was preparing to defend itself against a possible WTO case.
Investors bought shares in Chinese rare earth miners and Japanese rare earth processors on Wednesday, hoping the WTO action would force Beijing to allow more exports.
"Higher export quota potentially will allow them to sell more to overseas customers which are paying a high price for rare earth," said Felix Fok, analyst at research firm JI Asia.
Hong Kong-listed China Rare Earth Holdings jumped almost 17% on Wednesday, with peers Inner Mongolia Baotou Steel Rare-Earth Hi-Tech up 3% and Aluminium Corp of China up 2.5%.
In Japan, rare earth processor Alconix rose 4% and in Australia rare earth miners also climbed as the spotlight returned to a sector that had been struggling.
"Some of these rare earths stocks have been absolutely smashed," said Shaun Giacomo of Petras Capital in Sydney. Of the Australian listed miners, Alkane Resources rallied 13% and Araufura Resources 9.5%.
Re-election battle
Obama, who has faced criticism from Republican rivals for not being tough enough with Beijing, has hardened his stance on Chinese trade practices as he gears up for a re-election battle.
"Our competitors should be on notice. They will not get away with skirting the rules," Obama said.
The rare earths dispute, which has been building for years, comes as China undergoes a political transition, with Vice President Xi Jinping poised to become the leader of the world's second-largest economy by early 2013.
The US and Europe have clashed regularly with China over economic issues including the value of the Chinese currency. The US is due to make a preliminary decision next week on whether to impose countervailing duties on Chinese-made solar panels, potentially adding to trade tensions.
The rare earths case is the first to be jointly filed by the European Union, the US and Japan.
Though dependent on the outside world for vast qualities of industrial components such as iron and coal, China accounts for about 97% of world output of the 17 rare earth metals.
"China continues to make its export restraints more restrictive, resulting in massive distortions and harmful disruptions in supply chains for these materials throughout the global marketplace," said US trade representative Ron Kirk.
The action over China's export curbs involving rare earths, as well as tungsten and molybdenum, begins a 60-day process for the two sides to try to resolve the dispute.
Complaints 'lodged and heard'
The next step would be for the US, the EU and Japan to ask the WTO to establish a dispute-settlement panel to decide the case. Once appeals are lodged and heard, the process could take as long as two years to complete.
The EU, the US and Mexico won a similar case against China in January concerning other raw materials.
A European official close to the case said China had not removed wider export restrictions since that ruling. In particular, the EU said in a statement, rare earth quota announcements "are further tightening the restrictions and are a clear signal in the wrong direction".
Beijing has until the end of March to tell the US, the EU and Mexico how it intends to comply with the January ruling, providing an opportunity for China to address both that case and the rare earth restrictions at the same time, Kirk said in an interview.
"We are hopeful that because the WTO ruling in the raw materials case was so unequivocal that China will work with us," Kirk said.
Foreign companies pay up to twice as much as Chinese firms for rare earth metals, the EU said.
The EU directly imports €350-million worth of rare earths from China each year, and also brings in products of far greater value containing rare earths from Japan and elsewhere.
The damage done to European manufacturing runs into billions of euros, the official said, because it was nearly impossible to diversify away from Chinese supply. — Reuters

redpajama_set_name: RedPajamaCommonCrawl


text:
Tag: v
Weekend Update- Roe v. Wade Leaked Draft Opinion, Vladimir Putin to Undergo Cancer Surgery
Colin Jost
Michael Che
[Starts with Weekend Update intro]
Announcer: It's Weekend Update with Colin Jost and Michael Che.
[cheers and applause] [Cut to Colin Jost and Michael Che in their new set]
Colin Jost: Good evening everyone.
Michael Che: Welcome to Weekend Update. I'm Michael Che.
Colin Jost: I'm Colin Jost.
[Cut to Colin Jost in his news set. There's a picture of Mother's Day flowers at left top corner.]
Well, guys, tomorrow is Mother's Day, whether you want it to be one or not.
[picture changes to a news article that says "Roe V. Wade to be overturned"]
In an unprecedented move that could cause lasting damage to the Supreme Court, a draft opinion was leaked, which indicates that they intend to overturn Roe V. Wade. So the court is usually careful, but they slipped up just this once and now they've got to live with it forever. Hah! Sounds really unfair. The opinion was written by Justice Samuel Alito when he bases his arguments on laws from the 1600s. So it's an outdated opinion from an angry 70 year old. This shouldn't be a Supreme Court decision, it should just be a Facebook post. The opinion also seems like it was written in a weird conservative bubble. Here's how you know, he quotes his own colleague, Brett Kavanaugh six times, one for each beer in the pack. He even cites Kavanaugh on civil rights, which is like citing Amber Heard on how to make a bed.
[picture changes to John Roberts]
Chief Justice John Roberts said that the leak was quote "The work of one bad apple." One bad apple is also another legal argument used and Alito's opinion. [picture changes to a painting of Adam holding an apple ad a snake attacking him] [Cut to Michael Che. There's a picture of an article that says "Supreme Court has voted to overturn abortion rights, draft opinion shows" at right top corner.]
Michael Che: You know, as a man, there's no way I can understand the full impact of this issue. But I asked a bunch of women around the office, what their personal experience was with abortion. I gotta admit, I learned a lot from the HR meeting they made me go to as a result.
But I do know this ruling will have a disproportionate effect on poor people. I mean, most Americans don't have access to the same resources that I do. I mean, the average person can't just text Lorne in the middle of the night and say, "Yo, it happened again." I just don't get why Republicans are so against this. I mean, maybe don't think of it as an abortion. Think of it as a Patriots storming the uterus to overturn the results of an unfair pregnancy.
[Cut to Colin Jost. There's a picture of Rudy Giuliani at left top corner.]
Colin Jost: I know you're excited. Former New York City mayor and current Rumpelstiltskin, Rudy Giuliani, canceled an appearance before the January 6 committee at the last minute Friday after he was denied a request to record the interview. I assume on a loose VCR flashing 12 o'clock.
[picture changes to Vladimir Putin]
There are also unconfirmed reports that Vladimir Putin will undergo cancer surgery. Wow, I never thought I'd say this, but hey, good luck cancer.
Author Ajay KumarPosted on August 11, 2022 Categories 2022Tags Cancer, Colin Jost, day, Draft, episode 19, Leaked, Michael Che, Opinion, Putin, Roe, season 47, Surgery, to, Undergo, Update, v, Vladimir, Wade, Weekend, Weekend UpdateLeave a comment on Weekend Update- Roe v. Wade Leaked Draft Opinion, Vladimir Putin to Undergo Cancer Surgery
Weekend Update Justice Amy Coney Barrett on Overturning Roe v Wade
Amy Coney Barrett… Kate McKinnon
[Starts with Colin Jost in his set]
Colin Jost: The Supreme Court seemed poised to fully overturn Roe v. Wade. Here to comment is conservative justice Amy Coney Barrett.
[Amy Coney Barrett slides in]
Amy Coney Barrett: Hi.
Colin Jost: Hi, how are you?
Amy Coney Barrett: Good.
Colin Jost: Thank you for being here.
Amy Coney Barrett: I am jazzed and juiced.
Colin Jost: Right. I'm guessing you're pretty happy with the draft of the ruling?
Amy Coney Barrett: Well, I don't know what would make you think that other than everything I've ever said. But I listened to the case with an open mind and I asked all my question.
Colin Jost: Right there was one. Yeah, Justice Alito nodded to that in his opinion. You were asking about safe haven laws where you can legally leave a baby at a fire station no questions asked.
Amy Coney Barrett: That's right, Colin. I just don't understand why you need abortion because you can leave a baby anywhere in the United States. So like, what's the big deal? Just pop it. Just do the nine and plop.
Colin Jost: Just do the what?
Amy Coney Barrett: Just do your nine. You know, do your nine, leave it on the sidewalk. Wrap it up in a little Moses, put in a little basket. Send it down the creek. Just do your nine, you know? It's simple. You are a murderer, if you have an abortion. But you're not a murderer, if you put a baby in a bag in a mailbox and that tracks and is good to me.
Colin Jost: Okay, well, not everyone agrees with that.
Amy Coney Barrett: Well, just give it to a stork and the stork will give it to a lesbian. I would think that lesbians would be happy because now there's more babies for them to adopt till we ban that too. Come on, ladies. It's just nine. It's not even 10. So just do your nine and dump.
Colin Jost: I don't think it's that simple.
Amy Coney Barrett: Well, I have seven children and a job and I make it work. So why every single other woman can't do the same is beyond me. Unless I'm like missing something about class in America. Don't answer that.
Colin Jost: Okay, you were also suggesting that we don't need abortion because there's no longer the same stigma against unwed mother.
Amy Coney Barrett: Exactly, exactly. It's like you see a girl, you know she's pregnant. You're not going to stone her anymore. You're just gonna be like, "Huh, okay." Like if you get pregnant and you're not married, you don't have to go to a spooky convent anymore. You just give a baby to a panther, jungle book it, and that's your nine.
Colin Jost: Stop just saying that's your nine.
Amy Coney Barrett: Like, what is more traumatic? Safely ending an early pregnancy or giving full birth to a baby you can never see it again because you put it on a Ferris wheel? Colin, all I'm saying, these lesbians are going to have like a crapload of babies coming their way, they should be kissing my boobs.
Colin Jost: I don't think they want to do that. Also, I think a lot of Americans feel that you're kind of forcing conservative views on the country.
Amy Coney Barrett: Oh, well, look, the court is not partisan. Our spouses on the other hand are f-ing crazy. [phone vibrating] Excuse me.Speak of, Clarence Thomas's wife Ginni always texts me. She's like in love with me. I'm like, "Okay, lez, you want a baby?"
Colin Jost: Alright. Justice Barrett, is there anything else you would like to say?
Amy Coney Barrett: Arby's, we have the babies.
Colin Jost: Justice Barret, everyone.
Amy Coney Barrett: Do your nine!
Author Ajay KumarPosted on August 11, 2022 Categories 2022Tags Amy, Amy Coney Barrett, Barrett, Colin Jost, Coney, episode 19, Justice, Kate McKinnon, Michael Che, on, Overturning, Roe, season 47, Update, v, Wade, Weekend, Weekend UpdateLeave a comment on Weekend Update Justice Amy Coney Barrett on Overturning Roe v Wade
Roe v Wade Cold Open
Andrew Dismukes
Margaret… Cecily Strong
[Starts with a message video]
Male voice: In the draft of his majority opinion overturning Roe v. Wade, Justice Samuel Alito explains that no woman has a right to an abortion, and that, in fact, abortion is a crime. To prove it, he cites a treatise from 13th century England, about the quickening of the fetus, and a Second Treatise that says, if the quick child dies in her body, it would be a great misprision. We go now to that profound moment of moral clarity almost 1000 years ago, which later to clear foundation for what our law should be in 2022.
[Cut to three people in a room. It's about a thousand years back.]
Andrew: Whatever is the matter. You're looking flossed in thought.
Ben: It's nothing. It's just, while I was cleaning the hole on the side of the castle where we poop and then it falls through the sky into a moat full of human feces, I started to think about abortion.
Andrew: Really, what about it?
Ben: Well, don't you think we ought to make a law against it?
James: You mean, like the law we have against pointy shoes? Or the law that if you hunt deer in the royal forest, they cut off your genitals?
Ben: Exactly. Something fair and reasonable like those laws. We should make a law that would stand the test of time so that hundreds and hundreds of years from now, they'll look back and say, "No need to update this one at all. They nailed it back in 1235."
James: I don't know. Maybe we shouldn't ban abortion in all of England. We could decide it on a fiefdom by fiefdom basis.
Ben: Good idea. That way, if your concubine needs one, you could just send her off to get it in good old, old York City.
Andrew: But if we outlaw abortion, how would we punish the mother? Because she'll need to be punished. She'll be so happy about a crime.
Ben: We could always put her in a boat and let her sail off the cliff at the edge of the world. She would of course, tumbled down with the four giant turtles the holding up the earth, and maybe one of them would eat her.
Andrew: Yeah, kind of played out there.
James: I know. What if we get a donkey drunk and we dress it up in her husband's clothes. Then the next morning? She's like, "Did I just have sex with a donkey?" And the whole town's waiting outside like, "Ah, you're burnt."
Ben: Maybe, maybe. But what if the donkey get her pregnant and then we'd legally have to protect the fetus. And if the half donkey chili is a man that could become king.
Andrew and James: Ah! The prophecy.
Ben: But let's be careful. The worst thing that could happen if someone leaks this conversation to the town crier?
Margaret: Knock, knock. Just kidding. We don't have doors. Anyway, I was outside watching the sheriff throw left handed children into the river. And I couldn't help but overhear you talking about a new law?
Andrew: Oh-oh. Woman hear ideas and it make her think, "Why I no have those?"
Margaret: Yeah, something like that. So I have a couple of questions.
Ben: Careful Margaret. Don't make us make another hole in your skull so your brain can breathe.
Margaret: Right. I was just wondering since I'm almost at the childbearing age of 12, shouldn't women have the right to choose since having a baby means like a 50% chance of dying?
Ben: Yes, but that's why we're also offering maternity leaves. When you're done with 20 years of continuous maternity, you can leave.
Andrew: Shouldn't we at least make exceptions in cases of rape or incest?
James: But those are the only kinds of sex.
Margaret: You know, I guess I just don't understand why you're so obsessed with this issue? Like what about the fact that no one can read or write? Everyone's dying to plague?
Andrew: Oh, you think just because I have active plague, that means I need to wear a mask? It's my body, my choice.
Ben: Well, it's clear to me that we've reached the limits of human knowledge. We found the haircut. We know the sun is the moon when it's happy. We trust the Catholic Church with all our money and our children.
James: Plus we have birth control now. You can't get pregnant as long as when the man ejaculates, he whispers, "Just kidding." Well, there's always plan B, letting 1000 bees sting you.
Ben: Now, let's all vote. Men, who think we should outlaw abortion forever? Say I.
Andrew and James: I.
Ben: And who's opposed?
Chris: Me! I'm just playing. I know I can't vote but, you know, more is gonna be more. You ever get the feeling that this is not gonna be your century?
Kate: Enough!
Ben: My god! An ogre!
Kate: No, no, just a woman in her 30s. But I did eat a weird mushroom in a pile of cow dung, so I can see the future. And worry not dear girl. These barbaric laws will someday be overturned by something called progress. And then after about 50 years after the progress, they'll be like, "Maybe we should undo the progress." I don't know why my visions from that time are very confusing. Seems like all the power comes from a place called Florida. And if you think our customs are weird, you should watch the trial of Johnny Depp and Amber Heard. Listen, I know it doesn't sound great, but I guess no matter how many choices they take away from women, we have always had the choice to keep fighting. [cheers and applause]
Ben: That's really inspiring. And after hearing your perspective, I suddenly realize you're a witch and we're gonna set you on fire.
Kate: Alright, wouldn't be the first time.
All: And live from New York, it's Saturday night
Author Ajay KumarPosted on August 11, 2022 Categories 2022Tags Andrew Dismukes, Benedict Cumberbatch, Cecily Strong, Chris Redd, Cold, episode 19, James Austin Johnson, Kate McKinnon, Margaret, Open, Roe, season 47, v, WadeLeave a comment on Roe v Wade Cold Open
David Harbour Monologue
Joe Caucasian
SNL Transcripts: Candice Bergen: 12/11/76: Let's Kill Gary Gilmore For Christmas
Donald and Melania Trump Cold Open
SNL Transcripts: Amy Adams: 03/08/08: Goodnights
Aladin Magic Carpet Ride
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Weekend Update with Jimmy Fallon & Tina Fey
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Archive for the 'Bomb Factory In San Diego' Category
Posted: November 26, 2010 in Bomb Factory In San Diego, Homeland Terror Alerts
California Officials Pull Out of Homemade Bomb Factory, Citing Danger
Published November 26, 2010 | Associated Press
Explosives experts have pulled out of a northern San Diego County home with a large quantity of bomb-making materials because it's too dangerous.
The Sheriff's Department says "proactive operations on site have been suspended" and local, state and federal explosives experts are making plans to re-enter the home and remove hazardous materials.
No further action is expected until Dec. 1, at the earliest. Investigators say there is no immediate danger to the community.
Among other things, bomb technicians found what is believed to Pentaerythritol tetranitrate, or PETN, which was used in the 2001 airliner shoe-bombing attempt as well as in last month's airplane cargo bombs.
Fifty-four-year-old George Djura Jakubec is in jail after pleading not guilty on Monday to running a bomb factory at his home.
http://www.foxnews.com/us/2010/11/26/officials-pull-homemade-calif-bomb-factory-cite-danger/
Read more: http://www.foxnews.com/us/2010/11/26/officials-pull-homemade-calif-bomb-factory-cite-danger/#ixzz16PM7XrJm


During 11 of the 12 months, I ranged between 3-8 books a month. In July, though, I went a little mad: 33 books. The good news is that I'm reading faster than I'm acquiring. Also, the majority of the books were used.
A Fable - William Faulkner. For the Pulitzer pile.
Diary of a Wimpy Kid: The Ugly Truth - Jeff Kinney. I bought it for myself, but also with an eye towards the children's literature class next semester.
The Lost City of Z - David Grann. Christmas gift.
Louisa May Alcott: The Woman Behind Little Women - Harriet Reisen. I'm always up for anything Alcott: Stories? Sure. Bio? You bet! Trip to Concord? Let me pack a few things.
The Best of Everything - Rona Jaffe. I bought it to fill that Mad Men-shaped hole in my heart.
Storyteller: The Authorized Biography of Roald Dahl - Donald Sturrock. Christmas gift.
Leonard Maltin's 2011 Movie Guide - Leonard Maltin. Christmas gift.
Although I've exposed myself as the bookmadwoman that I am, I still find that this was a useful exercise and I'll continue monitoring my book purchases in 2011.
I celebrated the end of my (successful) 2010 book buying ban by going out New Year's Day and buying five books, ha! But they were all either discounted or used so I didn't spend that much, and I don't plan on making that many purchases going forward. Used bookstores will continue to be my downfall, I think - it's so hard to resist the treasures one finds there.
Congratulations on a successful book buying ban! I need to do that, too. Will I? Probably not.
I'm thinking of limiting myself to a 10 page a day buying cap. Which sounds good in theory, since I've avoided book stores for the past 8 days, but my kid's first scholastic catalog came home and I seem to have circled a years worth of books. Hmm, I need to come up with some hand-waving where books bought through schools don't count.


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<!DOCTYPE html>

    <link rel="stylesheet" href="../bower_components/openlayers/ol.css" />

    <openlayers ol-center="london" height="400"></openlayers>

Center map with URL synchronization example

This demo syncs the map center position with the URL, and viceversa, using the center-url-params property.

    <form>
        Latitude : <input type="number" step="any" ng-model="london.lat" />
        Longitude : <input type="number" step="any" ng-model="london.lon" />
        Zoom : <input type="number" step="any" ng-model="london.zoom" />
    </form>

Watsonville

Malibu

Garden Grove

Tijuana


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Posted in MusicWorld on August 17, 2006
It requires considerable artistic agility to write deeply personal songs that also reflect the broader world. That's just what platinum-certified Grammy-nominated singer/songwriter John Ondrasik and his band Five For Fighting has consistently accomplished on each of his previous CDs. Now with Two Lights, his new Aware/Columbia release, John delivers his most personal album to date, creating nothing less than an American family portrait.
John's Grammy-nominated song "Superman (It's Not Easy)," from the America Town CD, was already a hit when 9/11 happened. Afterwards, the song became a spiritual national anthem, and John joined superstar headliners Mick Jagger, Elton John, Paul McCartney and others for the post-9/11 fund-raiser "The Concert for New York." "Here's a kid just getting over shock of hearing himself on radio for first time," recalls John, "sitting at a piano in Madison Square Garden playing a song that seems to provide solace to the emergency workers and their families. Halfway through, seeing these burly firefighters with tears rolling down their faces: it was the most important thing I'll ever do musically."
In 2004 he recorded The Battle For Everything, which yielded the hit "100 Years," once again proving Ondrasik's ability to craft inspirational songs with a social message. "It means a lot as a writer when your songs find their way into everyday lives," he says. "To hear mp3s of '100 Years' sung at graduations, or to speak to folks about how certain songs helped out, inspires me to keep on swinging."
Two Lights should yield no less. Produced by John and band mates Curt Schneider (bass, guitars) and Andrew Williams (guitars), the album was inspired in part by conversations John had with ordinary Americans. Cops and cruisers, soldiers and surfers all have a place in John's America. Overall the CD is classic Americana, grittier and riskier than his previous work. That's especially so on songs like "California Justice" and the darkly comic "Policeman's Xmas Party," both based on real events.
Yet he also touches unflinchingly on the personal. The CD's debut single "The Riddle" is a song he wrote for his children, while the companion video features his beloved blue Mustang (a car passed down to John from his father and the inspiration for the song "'65 Mustang"). Says John of the single, "A lot of my songs touch on mortality, but at its heart it's a love song from a father to his son."
The father-son motif is most poignantly expressed in "Two Lights," a song that came to John after having dinner with a young soldier bound for Iraq, and the soldier's father, a Vietnam veteran. "I talked with the kid's father," John remembers. "In that moment, I saw a mixture of pride and fear in the old man's eyes. I wanted to write a song that talked about the reality of how these parents feel. The simple thing of 'Two Lights' is two lives: the father's and the son's. That's what inspired this song, the look of pride and fear in a father's eye."
Whatever subject he tackles, John's music is always infused with an empathetic spirit and sung in one of the most richly distinctive voices in contemporary pop. Still, the new CD may surprise those unaccustomed to the sharper edge of John's musical persona. "Producing is rewarding but also an extra slice of pain and suffering," he says. "Songs like 'The Riddle' and 'California Justice' are 90 percent craft, whereas others like 'Road to Heaven' and 'I Just Love You' are essentially live takes. In either case, the band has to be in the room, the clock has to be turned off, and the red light (or hard drive)...blinking."
John Ondrasik was born in L.A.'s sprawling San Fernando Valley, and grew up in a musical family. At two, he began studying piano and later added guitar. He majored in math at UCLA, but his heart was always in music. His hard work paid off, and today he's right where he wants to be: a working touring musician with a great family to come home to. "Being in a band," he says, "you spend a lot of months on a bus rolling through America. Unless you do that you don't have a sense of the expanse and the differences that make it so great. My music just comes from my experience putting the miles on tires."
Over the last year, John has also been busy working on music for films. He wrote, produced and performed "The Best," the main title song for the upcoming animated baseball-comedy feature Everyone's Hero (he also teamed up with country greats Brooks & Dunn to co-write "Keep On Swinging" for the same film). For the movie August Rush, John produced and wrote "Break," which is performed on screen by actor Jonathan Rhys-Meyers. Although primarily known for performing his own compositions, John also recorded a compelling new version of the classic Jimmy Webb composition, "All I Know" (a chart-topping pop hit song for Art Garfunkel in 1973), for the hit Walt Disney Pictures Film, Chicken Little.
But right now, Two Lights remains first and foremost in his musical life; that, and reaching out to an ever-expanding audience of admirers, whether in a darkened concert hall or on an iPod during morning rush hour. "I just try to get better as a songwriter," he says. "That's all I can do: try to write things that matter. At the end of the day all you can do is say what you believe."
Website: www.fiveforfighting.com
SOURCEMusicWorld TAGS Pop Rock Singer-Songwriter Musicworld On The Scene Artists Brooks & Dunn Fernando Five For Fighting Elton John John Ondrasik


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Duanesburg
Fort Edward
Dr. Duke Pesta - November 11, 2019
Why do so many university students embrace socialism and communism?
Dr. Duke Pesta
will be with us live via Skype to reveal the shocking truth campus indoctrination
O'Toole's Restaurant Event Room Kohl's Plaza
1814 Central Avenue, Colonie
For information:844-WAKEUP1
No charge, No food purchase required
Sponsored by the Capital District Chapters of the John Birch Society and the American Opinion Education Committee
Duke will offer unique insights about the mindset of progressive professors who are transforming university education into little more than an exercise in leftist social justice activism.
How has Judeo-Christian ethics been replaced by identity politics?
What assaults on your children occur in the amorality of the university system?
What do the educational planners really want to do with our children's minds, values, careers, and lives?
Join with us for Duke's clear explanation of this threat to our freedom, how we can fight it, and what steps parents and students can take to promote the true education.
Dr. Pesta received his M.A. in Renaissance literature from John Carroll University and his Ph.D. in Shakespeare and Renaissance literature from Purdue University. He has taught at major research institutions and small liberal arts colleges. He is a professor of English at the University of Wisconsin, Oshkosh, and the Academic Director of Freedom Project Education, a classical curriculum of internet courses.
Sponsored by the
Capital District Chapters of the
John Birch Society and the
American Opinion Education
Mission To bring about less government, more responsibility, and — with God's help — a better world by providing leadership, education, and organized volunteer action in accordance with moral and Constitutional principles.
American Opinion Education Committee
PO Box 1064, Ballston Lake, NY 12019
844-WAKEUP1 (844-925-3871)
The Constitution of the United States of America instituted the government that secures our God-given rights. The John Birch Society endorses the U.S. Constitution as the foundation of our national government, and works toward educating and activating Americans to abide by the original intent of the Founding Fathers. We seek to awaken a sleeping and apathetic people concerning the designs of those who are working to destroy our constitutional Republic.
John McManus recently gave a lecture exposing the dangers of holding a Constitutional Convention. See the VIDEO
Also, view John McManus' blog.
Preserving Individual Rights & National Independence "These United Colonies are, and of Right ought to be Free and Independent States … We hold these Truths to be self-evident, that all Men are created equal, that they are endowed by their Creator with certain unalienable Rights, that among these are Life, Liberty, and the Pursuit of Happiness."
The Declaration of Independence established the independence of both the original 13 American colonies and the United States of America that they together formed a decade later. The Declaration proclaimed that our personal rights come from God, not from government. — Declaration of Independence, 1776
The John Birch Society endorses the timeless principles of the Declaration of Independence. The Society also labors to warn against and expose the forces that seek to abolish U.S. independence, build a world government, or otherwise undermine our personal liberties and national independence.
Restoring the Constitution "That to secure these Rights, Governments are instituted among Men, deriving their just Powers from the Consent of the Governed." — Declaration of Independence, 1776
Disclaimer Statement ARTICLE - "This site is not the official website of the John Birch Society. For the national website go to The John Birch Society
The information contained on this site is to communicate information and events to local members and friends in NY State. The John Birch Society is not responsible for the content of any of the postings, articles, links, or notifications provided."


The Whiteline Transmission Mount Insert has been designed to add more reinforcement and structural rigidity to your existing transmission mount. This mount installs by filling the voided areas in the transmission mount and once it is installed, then it should reduce the lag in shift response while removing any slop in the rubber transmission mount. This insert has been made from durable polymer materials that will provide you with years of performance.
THIS DOES NOT FIT CVT VEHICLES.


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Andrew S. Fraker
Home > ORGANIZATION > CONTRIBUTING AUTHORS > Andrew S. Fraker
www.ngelaw.com
Andrew S. Fraker is a member of Neal Gerber Eisenberg's Intellectual Property & Technology Transactions practice group. His practice focuses on trademark and copyright matters. Andrew has also advised a number of clients on technology and intellectual property licensing transactions. He has worked with clients in the health care, electronics, technology and online industries, including for America's largest dental benefits provider, a leading DVD and video game rental company, and a leading online marketplace for musicians.
While in law school, Andrew was a judicial extern for the Honorable David Akemann of the Illinois 16th Judicial Circuit Court. Andrew was also a summer associate for Neal Gerber Eisenberg in 2012.
Articles in the National Law Review database by Andrew S. Fraker
Opening the Sky for Drones: FAA Issues Drone Rules for Commercial Flights (Posted On Thursday, June 23, 2016)
Drones - Division Between Federal and State Law and What it Means to You (Posted On Wednesday, February 17, 2016)
U.S. Brand Holders Anticipating Business in Cuba Can and Should Protect Trademarks (Posted On Tuesday, April 21, 2015)
Supreme Court Decision Gives Preclusive Effect to TTAB Rulings (Posted On Tuesday, April 14, 2015)
Landry's Inc. v. Flores: NLRB Ruling Bucks Trend, Hints that Non-Infringement Provisions in Employee Handbooks may be Lawful (Posted On Monday, August 11, 2014)
American Broadcasting Companies v. Aereo, Inc.: Supreme Court Departs from Volitional Act Test for Copyright Infringement (Posted On Thursday, July 3, 2014)


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Mayor Michael Hancock apologizes for comment…
NewsColorado News
Mayor Michael Hancock apologizes for comment about suggestive texts as officer accuses him of "telling additional lies"
Detective Leslie Branch-Wise backs Jamie Giellis in race for mayor
Helen H. Richardson, The Denver Post
Denver Mayor Michael Hancock, left, responds to a question and challenger Jamie Giellis listens during a debate sponsored by The Denver Post at the Denver Press Club on May 28, 2019.
By Jon Murray | jmurray@denverpost.com and Andrew Kenney | The Denver Post
PUBLISHED: May 29, 2019 at 1:33 p.m. | UPDATED: May 29, 2019 at 5:39 p.m.
Saying that "my bad judgment is a mistake that I own," Denver Mayor Michael Hancock apologized Wednesday for a debate remark explaining why he didn't think his suggestive texts to a security detail officer amounted to sexual harassment.
The mayor's statement came out shortly before the officer, Denver police Detective Leslie Branch-Wise, spoke out at a news conference alongside mayoral challenger Jamie Giellis, charging that Hancock was "blatantly telling additional lies."
Last year, Hancock apologized after Branch-Wise released a series of text messages he sent to her in 2012, during his first year in office. But they disagreed about whether the texts amounted to harassment.
Asked why during a Denver Post-hosted debate Tuesday night, Hancock suggested the released exchanges didn't include some of Branch-Wise's comments: "When you see the texts from Detective Branch-Wise, you see my texts," he said, prompting outcries from the crowd. "The reason I said it wasn't sexual harassment is because you don't see the back-and-forth conversation that occurred."
"It's clear to me that the mayor is blatantly telling additional lies," Branch-Wise said at Giellis' campaign headquarters in south Denver.
RELATED: Denver Mayor Michael Hancock and Jamie Giellis swing elbows in debate
"I have nothing to hide and nothing to prove," Branch-Wise added, challenging the mayor to bring forth any inappropriate text messages written by her. She said some apparent gaps in the text chains were pauses prompted by her shock at what the mayor had written.
Hancock had complimented Branch-Wise's dress and appearance in some of the texts and asked in another why women take pole-dancing classes. In one, he wrote that Branch-Wise "(makes) it hard on a brotha to keep it correct."
In his Wednesday statement, Hancock said: "I misspoke last night in a heated debate, and I want to apologize. The most important thing in all of this is that my behavior seven years ago was unacceptable and inappropriate. There is no justification for it, and it's something I am deeply sorry for."
Andrew Kenney, The Denver Post
Denver police Detective Leslie Branch-Wise, standing behind the lectern at right, speaks at a news conference with Denver mayoral challenger Jamie Giellis about text messages she received from Mayor Michael Hancock.
Branch-Wise provided a copy of the hand-written apology letter sent to her by Hancock in early 2018. She said the letter didn't refer to any of her own text messages or the role of any back-and-forth conversation.
Hancock's new statement said he understood that "the power dynamic between an employer and employee puts a special responsibility on the person in charge to make sure their interactions and communications with subordinates are professional."
Giellis last week called a news conference to decry the "culture of sexual harassment" at city hall. She reiterated that point Wednesday and said: "I believe Leslie."
On Wednesday afternoon, seeking to rebut Giellis' claims, Hancock's campaign issued an open letter signed by more than two dozen current and former female appointees. The letter said "the rampant mischaracterization of our workplace by the mayor's opponent is insulting to the highly skilled, experienced and qualified professional women who have chosen careers in public service in collaboration with and under the leadership of Mayor Hancock."
Mayor Michael Hancock's sexual harassment scandal still simmers for some Denver voters as runoff approaches
Denver detective says she was told "not to name the mayor" in harassment claim before receiving $75,000 settlement
Did Jamie Giellis flip-flop on camping ban repeal? Campaign says she wants to "replace" it after comments spark confusion
Branch-Wise, who had not spoken publicly about the election until last week, said she is supporting Giellis in Tuesday's runoff.
Giellis accused Hancock of waffling on what sexual harassment is.
"The mayor continues to blame the victim," Giellis said. "… If he hasn't learned, perhaps he continues to do it to others."
She and Branch-Wise were joined by former candidates Lisa Calderón and Penfield Tate, who both have endorsed Giellis.
Denver election 2019
denver mayor
Denver Politics
Jamie Giellis
Leslie Branch-Wise
Mayor Michael Hancock
Jon Murray | Enterprise and Transportation Reporter — The Denver Post
Jon Murray is an enterprise reporter on The Denver Post's government and politics team, with a focus on transportation and accountability reporting. He previously covered Denver city government. A Colorado native, he joined The Denver Post in 2014 after a decade at The Indianapolis Star. He graduated from Northwestern University with a bachelor's degree in journalism and history.
jmurray@denverpost.com
Follow Jon Murray @JonMurray
Andrew Kenney
Andrew Kenney covers Denver and its government. His work explores how urbanization is reshaping Colorado's cities and whom it benefits, focusing on housing, sustainability, culture and government accountability. He previously worked as a reporter for The (Raleigh) News & Observer and for Denverite. He is a graduate of the University of North Carolina at Chapel Hill and was honored with the Associated Press' Walter Spearman Award for young writers in 2015, among other recognition.
Follow Andrew Kenney andy.kenney Follow Andrew Kenney @AndyKnny


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NEWS: Inhofe, Whitehouse pledge to work together to ensure TSCA's passed in Senate
May 7, 2015 -
Kristina Baum – 202.224.6176
Donelle Harder – 202.224.1282
Inhofe, Whitehouse pledge to work together to ensure TSCA's passed in Senate
WASHINGTON, D.C. – A bipartisan group of Senators today announced in a press conference 14 new cosponsors to the Frank R. Lautenberg Chemical Safety for the 21st Century Act and urged Majority Leader Mitch McConnell to bring the bill to a vote on the Senate floor. The legislation would overhaul the nation's broken chemical safety law, the Toxic Substance Control Act (TSCA), which would make it the first successful reform of a major environmental law since the Clean Air Act Amendments of 1990.
In a rare occurrence, Senate Environment and Public Works (EPW) Committee Chairman Jim Inhofe (R-Okla.) and Sen. Sheldon Whitehouse (D-R.I.) stated they would stand together to ensure that an open amendment process to the TSCA reform legislation would serve to move the bill forward and on to the U.S. House of Representatives, instead of getting stalled or stopped due to controversial provisions.
During the press conference, Inhofe said, "There are going to be a lot of amendments. Senator Whitehouse and I don't always agree on everything. For that reason, I really believe that if it is something that he and I are both really interested in and consider it to be a top priority, than I don't think unfriendly amendments are going to get very far on this. We have gone through a process [with the bill] that is going to make that a lot easier to become a reality and be sent over to the House."
Whitehouse followed with, "One of the ways in which the Senate worked in the good old days, when the Senate worked, was that when a bill came to the floor, the cosponsors and the floor managers would stick together on votes that were likely to tear the underlying agreement apart. So you saw people on both sides of the aisle voting against amendments that they otherwise would be ardent supporters of, and indeed even cosponsors of, because they had an agreement to stand with one another and make sure this bill got through. I hope that is the kind of process we can get to when we get to the floor."
The Frank R. Lautenberg Chemical Safety for the 21st Century Act was introduced by U.S. Sens. Tom Udall (D-N.M.) and David Vitter (R-La.). The Environment and Public Works Committee passed the legislation out of committee on April 28 by a vote of 15-5.
The new cosponsors are: John Barrasso (R-Wyo.), Cory Booker (D-N.J.), John Cornyn (R-Texas), Tom Cotton (R-Ark.), Johnny Isakson (R-Ga.), Tim Kaine (D-Va.), Claire McCaskill (D-Mo.), Jeff Merkley (D-Ore.), Lisa Murkowski (R-Alaska), Chris Murphy (D-Conn.), Marco Rubio (R-Fla.), Tim Scott (R-S.C.), Jeanne Shaheen (D-N.H.), and Sheldon Whitehouse (D-R.I.).
Previously announced cosponsors are: Joe Manchin (D-W.V.), Roy Blunt (R-Mo.), Tom Carper (D-Del.), Chris Coons (D-Del.), John Boozman (R-Ark.), Joe Donnelly (D-Ind.), Jim Inhofe (R-Okla.); Shelley Moore Capito (R-W.V.), Martin Heinrich (D-N.M.), Bill Cassidy (R-La.), Heidi Heitkamp (D-N.D.), Mike Crapo (R-Idaho), Debbie Stabenow (D-Mich.), John Hoeven (R-N.D.), Rob Portman (R-Ohio), Mark Warner (D-Va.), Gary Peters (D-Mich.), Mike Rounds (R-S.D.), Sherrod Brown (D-Ohio), and John Thune (R-S.D.).
To watch the press conference in full, please click here: https://www.youtube.com/watch?v=YtIdtupD6BY&feature=youtu.be
Permalink: https://www.epw.senate.gov/public/index.cfm/2015/5/post-e0b7b2f5-b06c-1f6a-79a1-681a1c1ebbfb


Graphical solution of pure-time differential equations.
Graphical solution of pure-time differential equations by Duane Q. Nykamp is licensed under a Creative Commons Attribution-Noncommercial 4.0 License. For permissions beyond the scope of this license, please contact us.


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The Macintosh Quadra 840AV is a personal computer designed, manufactured, and sold by Apple Computer from July 1993 to July 1994. It was introduced alongside the Centris 660AV, where "AV" signifies audiovisual capabilities, such as video input and output, telecommunications, speech recognition, and enhanced audio. The 840AV has the same mini-tower form factor as the Quadra 800, with a faster Motorola 68040 processor.

The Quadra 840AV was discontinued shortly after the introduction of the PowerPC-based Power Macintosh. The Power Macintosh 8100/80AV provides the same functionality in the same form factor, and had a significantly higher price point. The 7100/66AV was priced comparably to the 840AV but in a IIvx-style desktop case.

Hardware

At launch, Quadra 840AV's 40 MHz Motorola 68040 CPU and interleaved RAM made it the fastest Macintosh available, topping both the nominally higher-end Quadra 950 and the Quadra 800 by 7 MHz. It remains both the fastest Quadra and the fastest 68k Macintosh of all time, because all later high-end Macintoshes are PowerPC-based Power Macintoshes. The 840AV is the only Mac to use the 40 MHz-clocked 68040. It sports a faster 66.7 MHz AT&T DSP 3210 Digital Signal Processor chip, compared with the 55 MHz variant in the 660AV. The on-board DSP was primarily intended to speed up audio/video processing, although few Mac programs make use of this due to the complexity of programming it.

The 840AV and its relative, the Centris/Quadra 660AV, marked a number of firsts for the Macintosh family. They are the first Macintoshes to include on-board 16-bit 48 kHz stereo audio playback and recording capability, and S-Video and composite video input and output. To improve video playback, two separate frame buffers are used: one for standard graphics, and one specifically for video. This enables the live video input to be displayed as a scalable "window" within the Macintosh user interface. They are also the first personal computers that supported speech recognition (PlainTalk) out-of-the-box. The Apple GeoPort Telecom Adapter Kit introduced with the AV Macs add many DSP-based telecommunication functions, such as modem, fax, and telephony.

The Quadra 840AV has a similar case to the earlier Macintosh Quadra 800; the housing, chassis, power supply, and internal storage assemblies are the same, but the front and rear panels changed, with the power button being moved to the front.

Internally, the 840AV is significantly different. Apart from the faster processor, the logic board lacks the 800's Processor Direct Slot and second ADB port, but has a DAV slot (in line with NuBus slot A) and the new GeoPort. Also, unlike the 800's 8 MB of fixed RAM, all of the 840AV's memory is in SIMMs (this is the reason why the maximum amount of memory is lower).

The way in which the 840AV deals with its memory (DRAM) differs from the other machines of its generation (Quadra 700, 800, 950) in that 4, 8, 16, or 32 MB 72-pin 60ns SIMMs may be installed up to 128 MB and sizes can be mixed. However, the Quadra 840AV does not support 1 MB, 2 MB, or 64 MB SIMMs. The 840AV and 660AV are the first Macintosh computers to operate in 32-bit mode at all times, and cannot be toggled back to 24-bit mode, which may be useful for using early Nubus cards that conform to the 24-bit addressing.

Notable uses
The Quadra 840AV was part of a hardware package that was offered with the initial release of Media 100.

Reception
Jonathan Chevreau of the National Post said on August 7, 1993 that the Quadra 840AV and Centris 660AV were the next most interesting multimedia computers behind the new SGI Indy, putting Apple among the forefront of the birth of the major industry of desktop multimedia.

Ben Thompson of  Byte magazine said in September 1993 that Apple and Silicon Graphics were trailblazers by setting audio and video input as default features of those two Macintosh and of the Indy desktop PCs, which "could change the way businesspeople communicate". He said the new AV Macs had a surprising leap in features, breaking Apple's trend of slow but stable incremental technology refreshes. He tested the 840AV as the overall fastest Macintosh, attributing this to its "radically" new AV series hardware features such as dedicated DMA channels for SCSI, serial, ethernet, and soundbut noted that the SCSI DMA performance is completely lost on the legacy architecture of System 7 pending a complete microkernel-based rewrite of the operating system such as with Pink or Copland. He tested the wealth of AV features such as telecommunications, print-to-fax, speech recognition, and video capture, and appreciated their productivity gains with surprisingly no compatibility problems.

Timeline

References

External links

 Macintosh Quadra 840AV: Technical Specifications at Apple Support
 Quadra 840AV at apple-history.com
 Quadra 840AV profile at Low End Mac
 Quadra 840AV at EveryMac.com

840AV
Quadra 840
Quadra 840AV
Computer-related introductions in 1993


text:
Fools Paradise, 2018
VR experience for HTC Vive and Oculus Rift
Fool's Paradise is a virtual world based on the "Proverbs of Hell" of English poet and artist William Blake. Intermedia data structures inform its visual and musical composition, developed in collaboration between artist Paul Hertz and composer Stephen Dembski. Fools Paradise was created as a VR performance for dancer and live music in the CAVE in 2004. The new version repurposes recorded music from the earlier version: everything else is new. Visually, Fools Paradise riffs on English Romantic gardens and the changing aesthetics of VR, from the CAVE to game engines and goggles. Perched on a highland in the form of an immense open book with a stream of language/water running down its center, the virtual world offers forty-eight interactive pavilions linked by a network of paths. Each pavilion interprets a proverb as a song composed by Stephen Dembski for soprano, flute, cello, and spoken voice, as a mask (by Mark Klink), and as calligraphy (by Koy Suntichotinun). Blake's proverbs reject intolerance and offer a plea for intellectual freedom that still resonates today. Fools Paradise pays homage to Blake as an intermedia artist avant la lettre, an artist who melded poetry with image in his handmade books.
Gallery version released 2018 by Digital Museum of Digital Art, http://dimoda.art/. Desktop version planned for 2019.
Gallery installation has a variable duration, from 5 to 10 minutes is typical. The pavilions with their masks and songs are reset for each visitor. Downloadable game version due for release in 2019 takes about an hour to visit all pavilions and includes exploration of other areas of the virtual world with information on William Blake and the artists involved in the project.
Paul Hertz is an independent artist, teacher, and curator. He has worked with computers for over thirty years, producing an extensive and varied body of algorithmic and interactive art. In Spain from 1971 to 1983, he collaborated with musicians and theatrical groups and developed an intermedia generative system, "IgnoTheory," which was used in the generative process of Fools Paradise and many earlier works. He delights in strange and responsive worlds, dysfunctional fortunetelling, faux symbolism, intermedia, code sourcery, glitching, and social interface design.
Ignot.us
Paulhertz.net
Cultural Heritage, Nature & Landscape, Parallel Worlds, Poetry & Language


text:
Doing what feels right (instead of what we wish felt right)
April 23, 2017 April 24, 2017 / havingitalt
If you read yesterday's post, you know I'm processing some intense feelings these days. Feelings of shame, of loss, and — at the same time — hope. All tied to finally, finally listening to my intuition and becoming the artist I'm meant to be.
So when Facebook reminded me of this blog post that my friend Lauree wrote about me a year ago, it felt like a bit of divine comedy. Because in it, she recounts how "right" it felt to me, just a year ago, to accept a job that had absolutely nothing to do with my art.
Nearly one year ago to the day my friend – writer and communications consultant Amanda Hirsch – along with her husband and young daughter uprooted from their home in Brooklyn to resettle near their families in Washington, D.C.
Nearly one year later to the day, they are moving back to New York City, and she's leaving her successful consulting business to return to corporate America.
Her post is about the "feeling of rightness" that led me to make this decision.
I think I can speak for most of the readers of her blog, Having it Alt, that this wasn't what any of us had in mind for her either. After hearing her story, though, it makes perfect sense.
"From our first conversation, I felt a strong connection…and the more we talked, the more I felt this pull — this feeling of rightness. When they asked if I might consider a new full-time role they were creating, I said yes, I was open to that. It turns out, that role is pretty much made for me."
Well, if you read yesterday's post, you know that this "perfect" role didn't last long. Less than a year after I started, my position was eliminated. And the guy I first spoke with, who seemed like such a kindred spirit? Gone, too.
Even before the layoff, that feeling of rightness was pretty quickly replaced with a feeling of, "Wait — what?" While I certainly enjoyed aspects of my time there, there were signs early on that this wasn't such a good fit, after all.
So where does that leave me?
What does it mean, when something feels so right, and then, it just isn't?
I think it means I'm a very good storyteller. And I spun myself a compelling yarn.
I told myself that here was an opportunity to make a good salary without selling out. That's been my deal, for years: Figuring out how to make money while working for a good cause so that with each day that passes that I'm not a full-time artist, at least I can rationalize that my time and energy is going somewhere worthwhile.
We needed the money, and here was a way to do it without feeling wrong in my own skin.
Except it did feel wrong.
Because no amount of work that isn't that work is ever going to be really, truly right.
But I couldn't face that, then (and I'm trying hard to face it now). Choosing to pursue my creative work full-time wasn't practical. It was irresponsible to harbor such dreams when there were bills to be paid.
So I convinced myself that a job that checked all these other boxes was "so right." Because I hoped, foolishly, that money and "stability" (if there is such a thing, which I don't think there is) would make me stop wanting what I really wanted.
"Look at fate intervening!", I told the world, because that is what I do, I tell the world, everything — because when I get the public narrative down it helps me tell the story to myself.
The truth is, it's fucking hard to be an artist. So I keep looking for the escape hatch, while also pining for more. It's a mind-fuck.
It would be a lot easier to want less from this world, from this life. To be satisfied with conventional things, with a 9-5 job. But I am not satisfied. I keep trying to come up with a reasonable game plan for my life that indulges the artist in me just enough to keep her happy, like giving a toddler a cookie to avoid a tantrum. My artist isn't a toddler, though, she's a grown-ass woman with grown-ass desires and she is frankly insulted to still be getting a cookie to shut her up. She is demanding more respect.
I think perhaps that the work of becoming ourselves is learning to know the difference between what feels right and what we wish felt right.
It feels like money solves everything. Like it's always the responsible thing to choose the path that leads to stability. But if stability is an illusion (because, hello? layoff. there are no guarantees), what happens when we stop chasing it (and money as a proxy for it) and instead allow ourselves to be the wild creatures we truly are? To listen to our own beating hearts? To stop telling ourselves stories that keep us playing small?
I don't have answers. I'm still terrified about money, truth be told. But I'm listening, universe. I'm noticing that denying who I truly am isn't leading to stability or a big fat bank account. I'm trying my hardest to do the brave thing.
I wish you the bravery you need this week.
P.S. This clip about from Fantastic Mr. Fox always resonated so deeply with me, as a reminder to honor the wildness inside of us (granted, he's a fox, but I think the message is for us human audience members).
Original background photo above by Patty Satijn on Flickr
Being an artist, Identity & self, Work & purpose
big decisions, decision-making, decisions, life choices, money, stability
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This Season find you perfect gift with Hotel Chocolat, luxury British Chocolatier and Cocoa Grower... Immerse yourself in their stylish range of gifts and hampers for alloccasions - birthday, wedding and to say thank you. Discover their commitment and devotion to making exciting, authenticand adventurous chocolate by unearthing exceptional ingredients andusing plenty of passion. So be sure to shop at Hotel Chocolat for the perfect gift this Valentine's Day, Mother's Day, Easter and Christmas.


text:
Preppy or preppie, is an American subculture associated with private university-preparatory schools.

Preppy, preppie, or preppies may also refer to:

 Preppie (album), by American R&B artist Cheryl Lynn
 Preppie! (video game), for the Atari 8-bit family
 Preppies (film), a 1984 comedy

See also

 Prepper (disambiguation)
 Prep (disambiguation)


greenandcleanuk.com ~ Window Curtain Ideas For Bedroom Model Image You can quickly transform that space into something usable and comfortable. We take a closer look at it as well as some alternatives. Window Curtain Ideas For Bedroom Model Image is one way to turn a dingy unfinished room into additional space that's attractive and comfortable. It does this by applying their expertise in building science and system design to the office.


Following the completion of The Point and Player & Media Centre, this new 150-bedroom Hilton Garden Inn will further cement the stadium's reputation as an outstanding sport and events facility. The new contemporary hotel will bring balance to the cricket ground by providing a 'sister' to The Point and mirror its relationship with The Pavillion. Together these three buildings will complete the drama and arena experience intended within the original Masterplan. The new hotel offers large terraces, balconies and extensive glazing to the bedrooms and hospitality areas. This design ensures that guests are able to capitalise on the magnificent views over the cricket field. This hotel showcases the latest in design, comfort and technology for guests and functions as a place to meet, socialise, work and play in a comfortable and relaxed atmosphere.


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NJ Resources, Inc. (NJR) recently designed and facilitated a customized training and exercise program for a two-day event in Mexico City, Mexico. Day one consisted of interactive classroom ICS training and was followed by a Worst-Case Discharge exercise based on a gas release from a transmission line scenario on the second day. The training program emphasized teambuilding and the ICS process, while the exercise allowed the participants to conduct first Responder activities utilizing the ICS processes learned in class.
The Incident Management Team (IMT) was comprised of first responders from Canada, the United States, and Mexico testing the company's Mexico Region response plan and their ability to respond to an incident in Mexico utilizing both local and international responders.
The exercise started at hour zero and had responders take all actions they normally would. The responders conducted notifications, assessments, source isolation, IMT activation, and mobilization of response resources appropriate to the scenario.
The program developed by NJR was very well received and the regional manager stated the interactive training and exercise program developed by NJR successfully accomplished what previous years of on-line training had failed to do, namely allowing responders to practice concepts that previously were only notional, not actual. The interactive learning fully engaged the responders, and the exercise allowed them to put in to practice the processes learned in class.


If Nobody Ever Finds It, Is It Really Lost?
As you may or not have heard Sasha mention in her rants, time travel is strange and wonderful and you cannot change history. You can cause history, you can spin off new timelines and you can kind of "cheat" history, but you can't change it in any meaningful way.
It's that cheating part I want to talk about today.
Sasha and I have told you about the "have your cake and eat it, too" way of duplicating a famous person (Abe Lincoln, Jack Kennedy, Ada Lovelace, Frank Zappa, etc) and bringing them to a point way in the future so they can live another, hopefully beneficial life. I've done it a couple of dozen times.
But what about stuff? Things? Can you bring those back to the present?
You can do it with pretty much anything, but the more you bring or the rarer it is now, the harder it is to explain. I love my complete collection of comics from the 50's & 60's, but since they are in brand new condition and complete runs, explaining them would be very difficult. Same goes for my DVD collection of every Doctor Who episode, even the lost ones.
Now, what I mostly want to cover is bringing loot from the past. Gold, silver, diamonds, artwork, etc. Stuff worth a lot of money. I'm not saying you go back and rob a bank or an art gallery or something, but then again, maybe you consider it.
Generally speaking, you can't do that easily. For one thing, if somebody gets a picture of you as you leap into your getaway car, it can cause no end of headaches later. Of course, there is also too much chance of getting shot or caught. But what you can do, is research "Lost (fill in the blank)" and then go find that stuff. Why? Because if it was never found by the time of your Absolute Now, who's to say what happened to it.
An example: A gang of 1920s bank robbers hit a bank for $100,000.00. They get away, but two days later all of them die in a shootout with the cops. The money is never found and the folks in the 21st century who make television shows about lost treasures have another story to try and solve.
But you, Friend Time Traveler, go back to the day of the robbery, put a small tracking device on their car, then use a drone to follow them. You learn that they put the money into an old well in Nowhereville, Kansas, so you get there after they leave, grab the cash and go back to your present secure in the knowledge that the well gets filled in sometime in 1933 and has a bigass grain elevator built on the spot in 1953.
Art the Nazis stole? It's yours, dude! You could keep it in a private collection or you could "find" it at some point and get huge rewards and your name in all the papers. Same could go for all the artwork the Nazi scum destroyed, but that is trickier to get hold of.
Did you ever wonder why they don't find more wrecked ships full of gold, silver and other loot? Time travelers! Ancient treasures, like, say, what was in those looted Egyptian tombs? Time travelers! Movies, recordings, television shows that are "lost"? Yep, time travelers.
So remember, kids: Finder's keepers, losers weepers.
Oh, and to keep from having to write another variation on this piece, collecting extinct animals or lost humans (IF they were truly lost. Many "lost" folks just get new identities) is WAY easier to do. Assuming you have a place in the present to hold them.


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The government of India launched an ambitious program to encourage the deployment of Energy Efficient chiller systems in the country here today. The Chiller Star Labelling Program has been formulated by Bureau of Energy Efficiency (BEE). The program envisages providing star rating in terms of its energy performance. Initially, the program is launched on a voluntary basis and will be valid up to 31st December 2020.
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Chillers, being energy intensive system, contribute more than 40% of the total energy consumption in commercial buildings. Therefore, it is important to optimize energy performance of chillers and create awareness amongst the end users to adopt transition towards energy efficient chillers.


text:
Зиемельблазма () — антиалкогольное общество в дореволюционной Риге. Преследовало цели культурного просвещения жителей города. Построенное обществом клубное здание (1913) до настоящего времени используется городом как дворец культуры.

История
Общество по борьбе с пропагандой алкоголя «Зиемельблазма» было основано на территории современного рижского микрорайона Вецмилгравис в 1904 году благодаря стараниям известного латышского мецената и подвижника Августа Домбровского. Домбровский фактически спонсировал создание и деятельность этого общества, не желая мириться с алкоголизацией населения этой окраины губернского центра. За некоторое время до этого, в 1887 году, он основал неподалёку первую лесопильню, тем самым обеспечив постоянной работой местных жителей, а в 1900 году благодаря его стараниям там же были открыты элементарная школа и детский сад.

Активное участие в деятельности общества «Зиемельблазма» (переводится с латышского языка как «Северное сияние», ранее «Северная заря») принимали видные деятели латышской литературы и общественной мысли: писатель и художник Янис Яунсудрабиньш (1877—1962), который с 1910 по 1913 годы оказывал всяческую поддержку в культурном просвещении населения района. Также следует отметить подвижническую деятельность другого известного латышского прозаика и поэта Леона Паэгле (1890—1926), который в период с 1911 по 1914 год регулярно выступал с докладами на темы национальной и мировой литературы и культуры.

Первое здание было выстроено в 1904 году на деньги мецената Домбровского, однако 21 января 1906 года оно было сожжено карательной экспедицией под руководством генерала Орлова, направленной губернскими властями на подавление беспорядков, вызванных революцией 1905—1907 годов. Ущерб составил 60 тысяч рублей. При экзекуции было расстреляно без суда четверо рабочих лесопилки Домбровского и трое избиты. Об этом факте среди прочих сообщил рижский депутат II Государственной думы, социал-демократ Иван (Янис) Озол, а социал-демократическая фракция Государственной думы внесла 2 апреля 1907 г. запрос в соответствующую комиссию.

Следующее здание, сохранившееся до наших дней, было построено в 1913 году; оно находится по адресу: улица Зиемельблазмас, 36. В первое десятилетие XX века в обществе был основан театр, начал активно выступать хор, открылся зал для художественных выставок и большая библиотека. Визитной карточкой организации были интеллектуально-просветительские вечера вопросов и ответов. Также по инициативе руководителей общества регулярно проводились спортивные мероприятия и детские праздники. Часто устраивались литературные вечера для широких кругов населения района (в основном представителей рабочего класса).

Современность
В марте 2011 года были начаты работы по реновации Дворца культуры. 4 мая 2013 года, после объёмных реновационных работ, состоялось торжественное открытие Дворца культуры и прилегающего к нему парка.

Примечания

Литература
 Grāpis, Andrejs. Augusts Dombrovskis. Mūžs un veikums. Index i. Rīga, 2006 432 lpp. ISBN 9984-632-30-X

Ссылки
 Дом культуры «Зиемельблазма» на портале Рижского самоуправления

Борьба с пьянством
Лифляндская губерния
Организации Латвии
История Риги
Вецмилгравис
Организации, основанные в 1904 году
Здания и сооружения, построенные в 1913 году
1913 год в Латвии


President Trump told reporters Tuesday that he thinks his daughter, Ivanka Trump, "would be dynamite" as a replacement to UN Ambassador Nikki Haley, who resigned this morning, but added that he fears he'd be accused of nepotism if he chose her.
What to watch: Trump also floated Dina Powell, his former deputy national security adviser, as a potential successor.
Update: Ivanka later tweeted, "It is an honor to serve in the White House alongside so many great colleagues and I know that the President will nominate a formidable replacement for Ambassador Haley. That replacement will not be me"


text:
Desmopressin, sold under the trade name DDAVP among others, is a medication used to treat diabetes insipidus, bedwetting, hemophilia A, von Willebrand disease, and high blood urea levels. In hemophilia A and von Willebrand disease, it should only be used for mild to moderate cases. It may be given in the nose, by injection into a vein, by mouth, or under the tongue.

Common side effects include headaches, diarrhea, and low blood sodium. The low blood sodium that results may cause seizures. It should not be used in people with significant kidney problems or low blood sodium. It appears to be safe to use during pregnancy. It is a synthetic analogue of vasopressin, the hormone that plays roles in the control of the body's osmotic balance, blood pressure regulation, kidney function, and reduction of urine production.

Desmopressin was approved for medical use in the United States in 1978. It is on the World Health Organization's List of Essential Medicines. It is available as a generic medication.

Medical uses

Bed wetting
Desmopressin is used to treat nocturnal enuresis (bedwetting). It is usually prescribed in the form of desmopressin acetate, by mouth. Children taking DDAVP have 2.2 fewer wet nights per week and are 4.5 times more likely to sleep without disruption compared with placebo.

Nocturia
In 2017, the FDA approved Desmopressin has some benefit for adults who have problems with nocturia (having a need to wake up at night for urination).

Bleeding disorders
Desmopressin (DDAVP) is usually the first line treatment for mild to moderate type 1 von Willebrand disease. It is not recommended in severe disease or in those with abnormal factor VIII. Usefulness in type 2A, 2M, or 2N von Willebrand disease is variable. Generally not recommended in 2B and type 3 von Willebrand disease.

Desmopressin is only recommended in mild hemophilia A. It may be used both for bleeding due to trauma or to try to prevent bleeding due to surgery. It is not effective in the treatment of hemophilia B (factor IX deficiency) or severe hemophilia A. May also be used in uremia induced bleeding.

Diabetes insipidus
Desmopressin is used in the treatment of central diabetes insipidus (DI) as a replacement for endogenous antidiuretic hormone (ADH) that is in insufficient quantity due to decreased or non-existent secretion or production of ADH by the posterior pituitary or hypothalamus, respectively. It is also used in the diagnostic workup for diabetes insipidus, in order to distinguish central from DI due to the kidneys. Desmopressin is not effective at treating nephrogenic DI, thus a positive response is generally indicative of central DI.

Side effects
 headaches
 facial flushing
 nausea
 hyponatremia
 seizures

US drug regulators added warning to the nasal sprays after two people died and fifty-nine other people had seizures. This occurred due to hyponatremia, a deficit of the body's sodium levels, and the nasal spray is no longer approved for use in children in the United States. However, US drug regulators have said that desmopressin tablets can still be considered safe for treatment of nocturnal enuresis in children as long as the person is otherwise healthy.

Patients must stop taking desmopressin if they develop severe vomiting and diarrhea, fever, the flu, or severe cold. Patients should also be very cautious about taking desmopressin during hot weather conditions or following strenuous exercise, as these conditions can place stress on the body's electrolyte and water balance.

A body needs to maintain a balance of water and sodium.  If sodium levels become too low (hyponatremia) – either as a result of increased water take-up or reduced salt levels – a person may have seizures and, in extreme cases, may die.

Mechanism of action
Desmopressin works by limiting the amount of water that is eliminated in the urine; that is, it is an antidiuretic. It works at the level of the renal collecting duct by binding to V2 receptors, which signal for the translocation of aquaporin channels via cytosolic vesicles to the apical membrane of the collecting duct. The presence of these aquaporin channels in the distal nephron causes increasing water reabsorption from the urine, which becomes passively re-distributed from the nephron to systemic circulation by way of basolateral membrane channels. Desmopressin also stimulates release of von Willebrand factor from endothelial cells by acting on the V2 receptor. It also increases endogenous levels of factor VIII, making it useful in the treatment of hemophilia A.

Desmopressin is degraded more slowly than recombinant vasopressin, and requires less frequent administration. In addition, it has little effect on blood pressure, while vasopressin may cause arterial hypertension. Vasopressin stimulates the release of ACTH, which indirectly increases responsiveness of alpha-1 receptor in blood vessel smooth muscle, increasing vessel tone and blood pressure. Several studies have shown that Desmopressin does not stimulate ACTH release (except in Cushing's Disease), and therefore does not directly raise blood pressure, however, one study showed that it stimulates ACTH release in over 50% of healthy subjects. Additionally, desmopressin is able to enhance ACTH and cortisol release in normal subjects following oCRH administration, but not in patients with anorexia nervosa.

Chemistry
Desmopressin (1-deamino-8-D-arginine vasopressin) is a synthetic form of the normal human hormone arginine vasopressin (the antidiuretic hormone, or ADH), a peptide containing nine amino acids.

Compared to vasopressin, desmopressin's first amino acid has been deaminated, and the arginine at the eighth position is in the dextro rather than the levo form (see stereochemistry).

References

Further reading

External links

Antidiuretics
Peptides
Wikipedia medicine articles ready to translate
Vasopressin receptor agonists
World Anti-Doping Agency prohibited substances
World Health Organization essential medicines


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Q: Yoast: do I still need to manually insert meta tags in my theme or will Yoast do this for me? I am using the Yoast Wordpress SEO plugin and would like to know if I need to insert meta tags into the head of my document or will Yoast do this for me assuming I've filled out the required fields in the back-end? Do I still need default meta tags or will Yoast be injecting its own?

A: It will use what's in your theme to write the meta tags.
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redpajama_set_name: RedPajamaStackExchange


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text:
Das CCTAktuellesProjekteVeranstaltungen
Erich-Paulun-InstitutChinaForum (CFT)
Innovative China: Alibaba's rural strategy and its international implications
Ying LOWREY, 刘鹰 Professor of Economics, Tsinghua University; Deputy Director of Tsinghua Research Center for Chinese Entrepreneurs.
Dr. Ying LOWREY is an Economic Professor at School of Social Sciences, Tsinghua University and Deputy Director of Tsinghua Research Center for Chinese Entrepreneurs, Senior Researcher of Tsinghua Research Institute of Innovation Development, Senior Adviser for several privately owned Chinese enterprises, and research or government institutions. Her teaching and research interests include Economics of Innovation and Entrepreneurship in the Internet and Platform Economy, Modern Microfinance Market, Business Demographics, Characteristics of Business Owners, and the Role of Free Enterprise in the Macroeconomy. She received her economics Ph.D. from Duke University, economics MA from Yale University and mathematics BA from Wuhan University. Before joining Tsinghua University in 2012, she served as senior economist at the Office of Advocacy, U.S. Small Business Administration; she taught many economic courses at George Washington University as assistant professor and San Diego State University as instructional professor. She was an assistant researcher at the Economic Institute, Chinese Academy of Social Science and assistant professor at Wuhan University.