text:
SanBio Tests Its Mesenchymal Stem Cell Line SB623 as a Treatment for Strokes
California-based biotechnology company, SanBio Inc., has announced the successful enrollment of its first patients in a Phase 1/2a clinical trial that will test the safety and efficacy of a novel stem cells product in the treatment of chronic deficits that are the product of strokes. This stem cell product is called SB623, and so far, 6 of 18 patients have been given this product. This clinical trial is being conducted at the University of Pittsburgh and Stanford University. The trial is being conducted at Stanford University and the University of Pittsburgh. Thus far, no safety concerns have been reported.
SB623 is a stem cell line that was originally derived from adult bone marrow stem cells. Specifically, mesenchymal stem cells were isolated from bone marrow and cultured. They were then genetically engineered to express a modified version of the "Notch" gene. The Notch gene encodes a protein that is embedded into the membrane and has regions that extend to the cell exterior and another portion that extends to the cell interior. The scientists who made SB623 forced the mesenchymal stem cells to express the internal portion of the Notch protein. The significance of this is simple; the internal portion of the Notch protein does all the work and the external portion of it regulates the internal portion. By expressing only the internal portion of the Notch protein, the scientists made a version of the Notch protein that is always active. When active, the Notch protein turns mesenchymal stem cells into cells that support neurons, which are the main functional cells of the nervous system that transmit neural impulses. Therefore, SB623 cells are derivatives of mesenchymal stem cells that have the capacity to form neurons or cells that greatly resemble neurons.
SanBio scientists and others have used SB623 cells in laboratory rodents that have sufered strokes. In all animal studies, SB623 cells appear to be safe and efficacious. Tate and colleagues published a paper in the journal Cell Transplantation in 2010 entitled, "Human mesenchymal stromal cells and their derivative, SB623 cells, rescue neural cells via trophic support following in vitro ischemia." This paper (Cell Transplant. 2010;19(8):973-84), SB623 cells were co-cultured with brain slices after those slices had been deprived of oxygen, which is exactly what happens to the brain during a stroke. SB623 cells or the medium that was used to grow SB623 cells rescued cells in the brain slices from dying. This effect was also dosage dependent.
In an earlier paper, SanBio scientists showed that SB623 cells made scaffolds of molecules that supported the growth of neurons (Aizman et al., J Neurosci Res. 2009 Nov 1;87(14):3198-206). In other work, scientists at Northwestern University implanted SB623 cells into the brains of rats with Parkinson's disease and showed that they prevented the death of dopaminergic neurons; the cells that usually die during Parkinson's disease (Glavaski-Joksimovic A,, et al., Cell Transplant. 2009;18(7):801-14). Therefore, the use of SB623 cells in rodents points to a potential for these cells as therapeutic agents in human disease.
The Chief Executive Officer for SanBio, Keita Mori, said of this trial, "This represents a major milestone in the human clinical testing of this important new approach for regenerative medicine. We are pleased to learn that the initial dose level was well tolerated." In this clinical trial, SB623 is implanted into the damaged region of the brains of stroke patients. Product safety is the primary focus of the study; however, particular tests and measurements of efficacy are also being tested.
SanBio's Vice President of Development, Ernest Yankee said, "The successful completion of the initial dose cohort is a major step in any first-in-human study. We are looking forward to initiating the next two dose cohorts and wrapping up the study. The safety findings thus far are very encouraging"
Posted on March 26, 2012 Categories Mesenchymal Stem Cells, Neurological treatmentsTags health, medicine, mesenchymal stem cells, research, sanbio inc, science


Eleanor joined The Barton Partnership in 2018, having previously spent a year working in a secondary school as an English and Languages assistant. Eleanor moved to London in 2017 immediately after she completed her final year exams at the University of Exeter where she graduated with a BA in History & French, complemented by a year of study in Brittany at the University of Rennes 2.
As a Research Consultant, Eleanor supports the Senior Consultants with searches across the four divisions: Commerce & Industry, Financial Services, Professional Services, and Private Equity.
Outside the office, Eleanor enjoys visiting her family back in Cardiff, socialising with friends over brunch, and wandering around museums and galleries.


text:
package net.poringsoft.wixossbrowser.utils;

import android.app.Activity;
import android.app.AlertDialog;
import android.content.Context;
import android.content.DialogInterface;
import android.content.pm.ActivityInfo;
import android.content.res.Configuration;
import android.view.WindowManager;
import android.widget.Toast;

import net.poringsoft.wixossbrowser.data.EnvOption;

import org.apache.http.HttpResponse;
import org.apache.http.HttpStatus;
import org.apache.http.client.ClientProtocolException;
import org.apache.http.client.ResponseHandler;
import org.apache.http.client.methods.HttpGet;
import org.apache.http.impl.client.DefaultHttpClient;
import org.apache.http.params.BasicHttpParams;
import org.apache.http.params.HttpConnectionParams;
import org.apache.http.params.HttpParams;
import org.apache.http.util.EntityUtils;

import java.io.IOException;
import java.util.Calendar;
import java.util.Collections;
import java.util.Comparator;
import java.util.List;

/**
 * ユーティリティ Static クラス
 * Created by mry on 2014/04/29.
 */
public class PSUtils {
    private static Toast s_toast = null;
    private static float s_scale = 0.0F;

    /**
     * トースト!(短め)
     * @param c コンテキスト
     * @param msg 表示メッセージ
     */
    public static void toast(Context c, String msg)
    {
        if (s_toast != null)
        {
            s_toast.cancel();
        }
        s_toast = Toast.makeText(c, msg, Toast.LENGTH_SHORT);
        s_toast.show();
    }

    /**
     * 整数変換を試みて失敗したらデフォルトを返す
     * @param text 数値文字列
     * @param def 失敗時のデフォルト値
     * @return 数値
     */
    public static int tryParseInt(String text, int def)
    {
        int ret = 0;
        try
        {
            ret = Integer.parseInt(text);
        }
        catch (Exception e)
        {
            ret = def;
        }

        return ret;
    }

    /**
     * 整数変換(long)を試みて失敗したらデフォルトを返す
     * @param text 数値文字列
     * @param def 失敗時のデフォルト値
     * @return 数値
     */
    public static long tryParseLong(String text, long def)
    {
        long ret = 0;
        try
        {
            ret = Long.parseLong(text);
        }
        catch (Exception e)
        {
            ret = def;
        }

        return ret;
    }

    /**
     * 論理値変換を試みて失敗したらデフォルトを返す
     * @param text true or false
     * @param def 失敗時のデフォルト値
     * @return 論理値
     */
    public static boolean tryParseBoolean(String text, boolean def)
    {
        boolean ret = false;
        try
        {
            ret = Boolean.parseBoolean(text);
        }
        catch (Exception e)
        {
            ret = def;
        }

        return ret;
    }

    /**
     * 文字列リストを整数リストとして降順で並び替える
     * @param strList
     * @return
     */
    public static void sortStringToIntDesc(List<String> strList)
    {
        Collections.sort(strList, new Comparator<String>() {
            @Override
            public int compare(String s1, String s2) {
                int i1 = PSUtils.tryParseInt(s1, 0);
                int i2 = PSUtils.tryParseInt(s2, 0);
                if (i1 == i2) {
                    return 0;
                } else if (i1 < i2) {
                    return 1;
                } else {
                    return -1;
                }
            }
        });
    }

    /**
     * DimensionのDP値リソースからピクセル値を取得する
     * @param context コンテキスト
     * @param resourceId リソースID
     * @return ピクセル値
     */
    public static int getPixcelFromDp(Context context, int resourceId) {
        return context.getResources().getDimensionPixelSize(resourceId);
    }

    /**
     * DIP値をPIXCEL値に変換する
     * @param context コンテキスト
     * @param dip DP値
     * @return ピクセル値
     */
    public static int dipToPixcel(Context context, int dip)
    {
        if (s_scale == 0.0F)
        {
            //未取得の場合は取得する
            s_scale = context.getResources().getDisplayMetrics().density;
        }

        return (int) (dip * s_scale + 0.5f);
    }

    /**
     * ダイアログを表示する
     * @param context コンテキスト
     * @param title タイトル
     * @param text メッセージ
     */
    public static void Alert(Context context, String title, String text)
    {
        AlertDialog dialog = new AlertDialog.Builder(context)
                .setTitle(title)
                .setMessage(text)
                .setPositiveButton("OK", new DialogInterface.OnClickListener() {
                    public void onClick(DialogInterface dialog, int whichButton) {
                        //何もしない
                    }
                })
                .create();
        dialog.show();
    }

    /**
     * ディスプレイの回転を禁止するかどうか
     * 禁止するときはenabeleをtrueにする
     * @param context コンテキスト
     * @param enable 禁止時はtrue, 有効時はfalse
     */
    public static void DisplayTurnEnable(Activity context, boolean enable)
    {
        if (enable)
        {
            OrientationFix(context, true);		//回転不可
            ScreenSleepEnable(context, false);	//スリープ不可
        }
        else
        {
            OrientationFix(context, false);		//回転許可
            ScreenSleepEnable(context, true);	//スリープ可
        }
    }

    /**
     * 縦横固定の設定をActivityに適用する
     * @param fixOrient 固定するならtrue,回転するように戻すならfalse
     */
    public static void OrientationFix(Activity context, boolean fixOrient)
    {
        if (fixOrient)
        {
            int ori = context.getResources().getConfiguration().orientation;
            if (ori == Configuration.ORIENTATION_LANDSCAPE)
            {
                context.setRequestedOrientation(ActivityInfo.SCREEN_ORIENTATION_LANDSCAPE);
            }
            else
            {
                context.setRequestedOrientation(ActivityInfo.SCREEN_ORIENTATION_PORTRAIT);
            }
        }
        else
        {
            context.setRequestedOrientation(ActivityInfo.SCREEN_ORIENTATION_UNSPECIFIED);
        }
    }

    /**
     * スクリーンスリープを許可する
     * @param enable trueの時スリープ可、falseのときスリープ不可
     */
    public static void ScreenSleepEnable(Activity context, boolean enable)
    {
        if (enable)
        {
            context.getWindow().clearFlags(WindowManager.LayoutParams.FLAG_KEEP_SCREEN_ON); 	//スリープ許可
        }
        else
        {
            context.getWindow().addFlags(WindowManager.LayoutParams.FLAG_KEEP_SCREEN_ON);		//スリープ禁止
        }
    }

    /**
     * バイナリデータ(画像・Flashなど)を取得しバイト配列で返す
     * @param url ダウンロードURL
     * @return バイナリデータ
     */
    public static byte[] getBinData(final String url)
    {
        HttpGet request = new HttpGet(url);
        HttpParams params = new BasicHttpParams();
        HttpConnectionParams.setSoTimeout(params, EnvOption.NET_GET_TIMEOUT);
        HttpConnectionParams.setConnectionTimeout(params, EnvOption.NET_GET_TIMEOUT);
        DefaultHttpClient httpClient = new DefaultHttpClient(params);

        byte[] rsult = null;
        try {
            rsult = httpClient.execute(request, new ResponseHandler<byte[]>() {
                @Override
                public byte[] handleResponse(HttpResponse response) throws IOException {
                    switch (response.getStatusLine().getStatusCode()) {
                        case HttpStatus.SC_OK:
                            //バイト配列に変換して返す
                            return EntityUtils.toByteArray(response.getEntity());
                        case HttpStatus.SC_NOT_FOUND:
                            throw new RuntimeException("データなしエラー");
                        default:
                            throw new RuntimeException("通信エラー code=" + response.getStatusLine().getStatusCode());
                    }
                }
            });
        } catch (ClientProtocolException e) {
            throw new RuntimeException(e);
        } catch (IOException e) {
            throw new RuntimeException(e);
        } finally {
            httpClient.getConnectionManager().shutdown();
        }

        return rsult;
    }
}

redpajama_set_name: RedPajamaGithub


text:
MEDIASCIENCE FIRSTS
Our Toolbox
Platforms & Measures
Audience Research Labs
Advertising Research
Brand Integration
In-Home Research
Legends Transcripts
Beyond 30 Studies
MEASURES & PLATFORMS
Mediascience+
Viewing time as a cross-media metric: Comparing viewing time for video advertising on television and online
MediaScience is the leading provider of lab-based audience research, incorporating a range of neuro-measures including biometrics, facial expression analysis, eye tracking, EEG, and more. With state-of-the-art labs in New York, Chicago, and Austin, MediaScience is discovering actionable insights in advertising, technology, media, and consumer trends.
Dr. Duane Varan, the global authority of neuromarketing research, founded Audience Labs (formerly the Interactive Television Research Institute) during his tenure at Murdoch University in Perth, Australia, in 2001. In 2005, he launched the Beyond : 30 Project, a consortium exploring the changing media and advertising landscape, and in 2008, he was approached by Disney Media Networks to set up a dedicated custom research lab on a broader scale – and so MediaScience was born. Though he officially left Murdoch in 2015, he continues to maintain some research links with the University of South Australia and has been widely recognised for his innovative contributions to teaching and the neuromarketing industry as evidenced by a long list of awards and over 90 published academic papers in his field.
Below is an abstract from one of his papers about comparing viewing time for video advertising on television and online from the Journal of Business Research.
The Media Rating Council recommends weighting advertising exposure by viewing time. Prior research shows viewing time has diminishing returns, implying that effectiveness equivalent to a 100% complete exposure could be achieved by a lower threshold. Results from four laboratory experiments, extending prior banner-ad research to dynamic video ads, suggest 75% viewed is a potential threshold. A second contribution identifies different viewing time distributions for television and online video, due to differences in ad avoidance. More television ads have viewing times exceeding the 75% threshold, and so are more effective than the typical online video ad. Online networks could charge fees equivalent to television ads for video ads that exceed the 75% threshold. A third contribution is the use of interval outcome estimation (IOE), which revealed asymmetric effects of viewing time and that brand familiarity rather than viewing time is the only necessary explanation of ad effectiveness measured by recall.
Bellman, Steven & Beal, Virginia & Wooley, Brooke & Varan, Duane. (2020). Viewing time as a cross-media metric: Comparing viewing time for video advertising on television and online. Journal of Business Research. 120. 103-113. 10.1016/j.jbusres.2020.07.034.
Click here to request the full text
© 2023 MediaScience | Sitemap

redpajama_set_name: RedPajamaCommonCrawl


text:
local naughty=require("naughty")

module("notify")
local info=nil
local noti={}
function noti.new_notify(title,text, font, timeout)
    local _font = font or nil
    local _timeout = timeout or 1
    if info ~= nil then
        naughty.destroy(info)
        info=nil
    end
    if title ~= nil or text ~= nil then
        info=naughty.notify({title=title, text=text, font=_font, timeout=_timeout})
    end
end

return noti


Image Title: Outstanding Ohana Outdoor Patio Wicker Furniture 7 Piece Luxury Seating Set With With Regard To Ohana Outdoor Furniture Ordinary. Filename: outstanding-ohana-outdoor-patio-wicker-furniture-7-piece-luxury-seating-set-with-with-regard-to-ohana-outdoor-furniture-ordinary.jpg. Image Dimension: 600 x 400 pixels. Images Format: jpg/jpeg. Publisher/Author: Mackenzie Bayer. Uploaded Date: Tuesday - January 29th. 2019 02:48:41 AM. Category: Home Design. Image Source: freshome.com.
Tap The Thumbnail Bellow to See Related Gallery of "Outstanding Ohana Outdoor Patio Wicker Furniture 7 Piece Luxury Seating Set With With Regard To Ohana Outdoor Furniture Ordinary"


text:
Übersetzen Sie die folgenden Sätze auf Schweizerdeutsch.

Wenn Sie die Schweizerdeutsche Version sehen wollen, klicken Sie darauf.

1

Ich
wollte nach Rom fahren.

Ich ha
uf Rom wölle fahre.

2

Wir mussten
im Hotel bleiben.

Mir
händ im Hotel müesse bliibe.

3

Du
gehst in den Wald.

Du
gahsch in Wald.

4

Sandro
fährt ans Meer.

De
Sandro fahrt a s Meer.

5

Heute
gehen wir an die Limmat.

Hüt
gömmer a d Limmat.

6

Im Mai
fahren sie in die Berge.

Im Mai
fahred sie i d Berge.

7

2013
war ich am Mittelmeer.

2013
bini am Mittelmeer gsii.

8

Wart
ihr schon einmal im Dschungel?

Sind
ihr scho emal im Dschungel gsii?

9

Im
Oktober waren wir auf einer Insel.

Im
Oktober simmer uf ere-n-Insle gsii.

10

Rita
war an einem schönen Strand.

D Rita
isch amene schöne Strand gsii.

11

Sollen
wir aufs Land fahren?

Söllemer
uf s Land fahre?

12

Am
Nachmittag gehe ich mich sonnen.

Am
Namittag gahni go sönnele.

13

Im
Herbst gehen wir gern wandern.

Im
Herbscht gömmer gern go wandere.

14

Um
08:00 Uhr gibt es Frühstück.

Am
achti gits Zmorge.

15

Macht ihr
einen Ausflug in die Stadt?

Mached
ihr en Usflug i d Stadt?


The second most common grade (after 304); for food and surgical stainless steel uses; Alloy SS316 is often used for building nuclear reprocessing plants.
Stainless steels are widely used in food and beverage manufacturing and processing Is 316 type the only stainless steel that is classed as the 'food' grade?
Some of the applications 316 metals are used for include food prep equipment, pollution The 316 alloy metal is known as the marine grade stainless steel.
Stainless Steel | M&K Metal Co.
Aug 19, 2015 The two most common stainless steel grades are 304 and 316. from most oxidizing acids and is often used for kitchen and food applications.
When it comes to supplying food-grade metal products into this critical market, TW and 316, nickel alloys, duplex alloys, titanium, 15-5 and 17-4 grades of stainless steel We offer food grade sheets, pipes, and tubing in various metal alloys.


Here are some of the things an individual should keep in mind when he/she is dealing with depression.
1.	It is alright to do nothing.
2.	Try to look to walk somebody's dog and try to get out the house for once.
3.	Put on your walking shoes and just go out and take a nice stroll.
4.	Join various support groups to help others and also yourself.
5.	Things will be hard when in depression, so fight them.
6.	Whenever it is possible, eat at home.
7.	Always have a simple routine.


No one will argue that floodplain mapping has greatly improved since the first maps were drawn in the early 1970s. At the same time data management in general has greatly improved. When combining digital flood insurance rate maps with data sets from places such as Department of Taxation and Finance, FEMA, Department of Environmental Conservation, Cornell University Geospatial Information Repository and the NYS GIS Clearinghouse helpful maps and other tools can be created for the floodplain manager. This presentation will explore GIS maps for floodplain managers, data availability, data quality, and their impacts on floodplain management. Will explain the variety of layers that we use in order to spot potential trouble areas, and potential uses of this data for mitigation, planning, and mapping activities. Will also talk about how it can be used in post disaster response.