Bidlack JM, Knapp BI, Deaver DR, Plotnikava M, Arnelle D, Wonsey AM, Toh MF, Pin SS, Namchuk MN. "In Vitro Pharmacological Characterization of Buprenorphine, Samidorphan, and Combinations Being Developed as an Adjunctive Treatment of Major Depressive Disorder." The Journal of pharmacology and experimental therapeutics.. 2018 Nov 0; 367(2):267-281. Epub 2018 Aug 14.
Callaghan CK, Rouine J, Dean RL, Knapp BI, Bidlack JM, Deaver DR, O'Mara SM. "Antidepressant-like effects of 3-carboxamido seco-nalmefene (3CS-nalmefene), a novel opioid receptor modulator, in a rat IFN-?-induced depression model." Brain, behavior, and immunity.. 2018 Jan 0; 67:152-162. Epub 2017 Aug 24.
Lefever M, Li Y, Anglin B, Muthu D, Giuvelis D, Lowery JJ, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. "Structural Requirements for CNS Active Opioid Glycopeptides." Journal of medicinal chemistry.. 2015 Aug 13; 58(15):5728-41. Epub 2015 Jul 23.
Li Y, St Louis L, Knapp BI, Muthu D, Anglin B, Giuvelis D, Bidlack JM, Bilsky EJ, Polt R. "Can amphipathic helices influence the CNS antinociceptive activity of glycopeptides related to ?-endorphin?" Journal of medicinal chemistry.. 2014 Mar 27; 57(6):2237-46. Epub 2014 Mar 07.
Sromek AW, Provencher BA, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. "Preliminary pharmacological evaluation of enantiomeric morphinans." ACS chemical neuroscience.. 2014 Feb 19; 5(2):93-9. Epub 2014 Jan 08.
Bidlack JM. "Mixed ?/? partial opioid agonists as potential treatments for cocaine dependence." Advances in pharmacology.. 2014 69:387-418.
Provencher BA, Sromek AW, Li W, Russell S, Chartoff E, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and pharmacological evaluation of aminothiazolomorphinans at the mu and kappa opioid receptors." Journal of medicinal chemistry.. 2013 Nov 14; 56(21):8872-8. Epub 2013 Oct 29.
Vanalstine MA, Wentland MP, Alvarez J, Cao Q, Cohen DJ, Knapp BI, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 9: Synthesis, characterization and molecular modeling of pyridinyl isosteres of N-BPE-8-CAC (1), a high affinity ligand for opioid receptors." Bioorganic & medicinal chemistry letters.. 2013 Apr 1; 23(7):2128-33. Epub 2013 Feb 08.
Hoot MR, Sypek EI, Reilley KJ, Carey AN, Bidlack JM, McLaughlin JP. "Inhibition of G??-subunit signaling potentiates morphine-induced antinociception but not respiratory depression, constipation, locomotion, and reward." Behavioural pharmacology.. 2013 Apr 0; 24(2):144-52.
Wentland MP, Jo S, Gargano JM, Vanalstine MA, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 8. High affinity ligands for opioid receptors in the picomolar Ki range: oxygenated N-(2-[1,1'-biphenyl]-4-ylethyl) analogues of 8-CAC." Bioorganic & medicinal chemistry letters.. 2012 Dec 15; 22(24):7340-4. Epub 2012 Oct 27.
Neumeyer JL, Zhang B, Zhang T, Sromek AW, Knapp BI, Cohen DJ, Bidlack JM. "Synthesis, binding affinity, and functional in vitro activity of 3-benzylaminomorphinan and 3-benzylaminomorphine ligands at opioid receptors." Journal of medicinal chemistry.. 2012 Apr 26; 55(8):3878-90. Epub 2012 Apr 04.
Li Y, Lefever MR, Muthu D, Bidlack JM, Bilsky EJ, Polt R. "Opioid glycopeptide analgesics derived from endogenous enkephalins and endorphins." Future medicinal chemistry.. 2012 Feb 0; 4(2):205-26.
Dean RL, Eyerman D, Todtenkopf MS, Turncliff RZ, Bidlack JM, Deaver DR. "Effects of oral loperamide on efficacy of naltrexone, baclofen and AM-251 in blocking ethanol self-administration in rats." Pharmacology, biochemistry, and behavior.. 2012 Jan 0; 100(3):530-7. Epub 2011 Oct 25.
Yeomans L, Muthu D, Lowery JJ, Martinez HN, Abrell L, Lin G, Strom K, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. "Phosphorylation of enkephalins: NMR and CD studies in aqueous and membrane-mimicking environments." Chemical biology & drug design.. 2011 Nov 0; 78(5):749-56. Epub 2011 Sep 26.
Zhang B, Zhang T, Sromek AW, Scrimale T, Bidlack JM, Neumeyer JL. "Synthesis and binding affinity of novel mono- and bivalent morphinan ligands for ?, ?, and ? opioid receptors." Bioorganic & medicinal chemistry.. 2011 May 1; 19(9):2808-16. Epub 2011 Mar 26.
Hough LB, Nalwalk JW, Yang J, Conroy JL, VanAlstine MA, Yang W, Gargano J, Shan Z, Zhang SZ, Wentland MP, Phillips JG, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X. "Brain P450 epoxygenase activity is required for the antinociceptive effects of improgan, a nonopioid analgesic." Pain.. 2011 Apr 0; 152(4):878-87.
Zhang T, Yan Z, Sromek A, Knapp BI, Scrimale T, Bidlack JM, Neumeyer JL. "Aminothiazolomorphinans with mixed ? and ? opioid activity." Journal of medicinal chemistry.. 2011 Mar 24; 54(6):1903-13. Epub 2011 Feb 25.
Lowery JJ, Raymond TJ, Giuvelis D, Bidlack JM, Polt R, Bilsky EJ. "In vivo characterization of MMP-2200, a mixed ?/? opioid agonist, in mice." The Journal of pharmacology and experimental therapeutics.. 2011 Mar 0; 336(3):767-78. Epub 2010 Nov 30.
Balboni G, Salvadori S, Marczak ED, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Si YG, Neumeyer JL. "Opioid bifunctional ligands from morphine and the opioid pharmacophore Dmt-Tic." European journal of medicinal chemistry.. 2011 Feb 0; 46(2):799-803. Epub 2010 Dec 08.
Fulton BS, Knapp BL, Bidlack JM, Neumeyer JL. "Effect of linker substitution on the binding of butorphan univalent and bivalent ligands to opioid receptors." Bioorganic & medicinal chemistry letters.. 2010 Mar 1; 20(5):1507-9. Epub 2010 Jan 25.
Conroy JL, Fang C, Gu J, Zeitlin SO, Yang W, Yang J, VanAlstine MA, Nalwalk JW, Albrecht PJ, Mazurkiewicz JE, Snyder-Keller A, Shan Z, Zhang SZ, Wentland MP, Behr M, Knapp BI, Bidlack JM, Zuiderveld OP, Leurs R, Ding X, Hough LB. "Opioids activate brain analgesic circuits through cytochrome P450/epoxygenase signaling." Nature neuroscience.. 2010 Mar 0; 13(3):284-6. Epub 2010 Feb 07.
Balboni G, Salvadori S, Trapella C, Knapp BI, Bidlack JM, Lazarus LH, Peng X, Neumeyer JL. "Evolution of the Bifunctional Lead ? Agonist / ? Antagonist Containing the Dmt-Tic Opioid Pharmacophore." ACS chemical neuroscience.. 2010 Feb 17; 1(2):155-164.
Decker M, Si YG, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and opioid receptor binding affinities of 2-substituted and 3-aminomorphinans: ligands for mu, kappa, and delta opioid receptors." Journal of medicinal chemistry.. 2010 Jan 14; 53(1):402-18.
Decker M, Fulton BS, Zhang B, Knapp BI, Bidlack JM, Neumeyer JL. "Univalent and bivalent ligands of butorphan: characteristics of the linking chain determine the affinity and potency of such opioid ligands." Journal of medicinal chemistry.. 2009 Dec 10; 52(23):7389-96.
Wentland MP, Lou R, Lu Q, Bu Y, Denhardt C, Jin J, Ganorkar R, VanAlstine MA, Guo C, Cohen DJ, Bidlack JM. "Syntheses of novel high affinity ligands for opioid receptors." Bioorganic & medicinal chemistry letters.. 2009 Apr 15; 19(8):2289-94. Epub 2009 Feb 25.
Wentland MP, Lu Q, Ganorkar R, Zhang SZ, Jo S, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 7: syntheses and opioid receptor properties of cyclic variants of cyclazocine." Bioorganic & medicinal chemistry letters.. 2009 Jan 15; 19(2):365-8. Epub 2008 Nov 24.
Wentland MP, Lou R, Lu Q, Bu Y, VanAlstine MA, Cohen DJ, Bidlack JM. "Syntheses and opioid receptor binding properties of carboxamido-substituted opioids." Bioorganic & medicinal chemistry letters.. 2009 Jan 1; 19(1):203-8. Epub 2008 Nov 07.
Bidlack JM, Morris HH. "Phenobarbital withdrawal seizures may occur over several weeks before remitting: human data and hypothetical mechanism." Seizure.. 2009 Jan 0; 18(1):79-81. Epub 2008 Aug 03.
Keyari CM, Knapp BI, Bidlack JM, Lowey J, Bilsky EJ, Polt R. "Glycosyl-enkephalins: synthesis and binding at the mu, delta & kappa opioid receptors. Antinociception in mice." Advances in experimental medicine and biology.. 2009 611:495-6.
Mathews JL, Smrcka AV, Bidlack JM. "A novel Gbetagamma-subunit inhibitor selectively modulates mu-opioid-dependent antinociception and attenuates acute morphine-induced antinociceptive tolerance and dependence." The Journal of neuroscience : the official journal of the Society for Neuroscience.. 2008 Nov 19; 28(47):12183-9.
Mathews JL, Fulton BS, Negus SS, Neumeyer JL, Bidlack JM. "In vivo characterization of (-)(-)MCL-144 and (+)(-)MCL-193: isomeric, bivalent ligands with mu/kappa agonist properties." Neurochemical research.. 2008 Oct 0; 33(10):2142-50. Epub 2008 Jun 05.
Fulton BS, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and pharmacological evaluation of hydrophobic esters and ethers of butorphanol at opioid receptors." Bioorganic & medicinal chemistry letters.. 2008 Aug 15; 18(16):4474-6. Epub 2008 Jul 17.
Wentland MP, Sun X, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 6: Opioid receptor binding properties of cyclic variants of 8-carboxamidocyclazocine." Bioorganic & medicinal chemistry.. 2008 May 15; 16(10):5653-64. Epub 2008 Mar 30.
Reed B, Bidlack JM, Chait BT, Kreek MJ. "Extracellular biotransformation of beta-endorphin in rat striatum and cerebrospinal fluid." Journal of neuroendocrinology.. 2008 May 0; 20(5):606-16. Epub 2008 Mar 15.
VanAlstine MA, Wentland MP, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 5. Opioid receptor binding properties of N-((4'-phenyl)-phenethyl) analogues of 8-CAC." Bioorganic & medicinal chemistry letters.. 2007 Dec 1; 17(23):6516-20. Epub 2007 Sep 29.
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "In-vitro investigation of oxazol and urea analogues of morphinan at opioid receptors." Bioorganic & medicinal chemistry.. 2007 Jun 15; 15(12):4106-12. Epub 2007 Mar 30.
Zhang A, Li F, Ding C, Yao Q, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and pharmacological evaluation of 6,7-indolo/thiazolo-morphinans--further SAR of levorphanol." Journal of medicinal chemistry.. 2007 May 31; 50(11):2747-51. Epub 2007 May 09.
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "Pharmacological properties of bivalent ligands containing butorphan linked to nalbuphine, naltrexone, and naloxone at mu, delta, and kappa opioid receptors." Journal of medicinal chemistry.. 2007 May 3; 50(9):2254-8. Epub 2007 Apr 04.
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "High-affinity carbamate analogues of morphinan at opioid receptors." Bioorganic & medicinal chemistry letters.. 2007 Mar 15; 17(6):1508-11. Epub 2007 Jan 17.
Lowery JJ, Yeomans L, Keyari CM, Davis P, Porreca F, Knapp BI, Bidlack JM, Bilsky EJ, Polt R. "Glycosylation improves the central effects of DAMGO." Chemical biology & drug design.. 2007 Jan 0; 69(1):41-7.
Wentland MP, VanAlstine M, Kucejko R, Lou R, Cohen DJ, Parkhill AL, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. 4. Opioid receptor binding properties of 8-[N-(4'-phenyl)-phenethyl)carboxamido] analogues of cyclazocine and ethylketocycalzocine." Journal of medicinal chemistry.. 2006 Sep 7; 49(18):5635-9.
Neumeyer JL, Peng X, Knapp BI, Bidlack JM, Lazarus LH, Salvadori S, Trapella C, Balboni G. "New opioid designed multiple ligand from Dmt-Tic and morphinan pharmacophores." Journal of medicinal chemistry.. 2006 Sep 7; 49(18):5640-3.
"Opioid receptors and signaling on cells from the immune system." Journal of neuroimmune pharmacology : the official journal of the Society on NeuroImmune Pharmacology.. 2006 Sep 0; 1(3):260-9. Epub 2006 Jul 08.
Nefzi A, Ostresh JM, Appel JR, Bidlack J, Dooley CT, Houghten RA. "Identification of potent and highly selective chiral tri-amine and tetra-amine mu opioid receptors ligands: an example of lead optimization using mixture-based libraries." Bioorganic & medicinal chemistry letters.. 2006 Aug 15; 16(16):4331-8. Epub 2006 Jun 05.
Parkhill AL, Bidlack JM. "Reduction of lipopolysaccharide-induced interleukin-6 production by the kappa opioid U50,488 in a mouse monocyte-like cell line." International immunopharmacology.. 2006 Jun 0; 6(6):1013-9. Epub 2006 Feb 17.
Sun B, Tipton CM, Bidlack JM. "The expression of prodynorphin gene is down-regulated by activation with lipopolysaccharide in U-937 macrophage cells." Journal of neuroimmunology.. 2006 May 0; 174(1-2):52-62. Epub 2006 Feb 17.
Bonacci TM, Mathews JL, Yuan C, Lehmann DM, Malik S, Wu D, Font JL, Bidlack JM, Smrcka AV. "Differential targeting of Gbetagamma-subunit signaling with small molecules." Science.. 2006 Apr 21; 312(5772):443-6.
Peng X, Knapp BI, Bidlack JM, Neumeyer JL. "Synthesis and preliminary in vitro investigation of bivalent ligands containing homo- and heterodimeric pharmacophores at mu, delta, and kappa opioid receptors." Journal of medicinal chemistry.. 2006 Jan 12; 49(1):256-62.
Bart G, Schluger JH, Borg L, Ho A, Bidlack JM, Kreek MJ. "Nalmefene induced elevation in serum prolactin in normal human volunteers: partial kappa opioid agonist activity?" Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2005 Dec 0; 30(12):2254-62.
Mathews JL, Peng X, Xiong W, Zhang A, Negus SS, Neumeyer JL, Bidlack JM. "Characterization of a novel bivalent morphinan possessing kappa agonist and micro agonist/antagonist properties." The Journal of pharmacology and experimental therapeutics.. 2005 Nov 0; 315(2):821-7. Epub 2005 Aug 02.
Zhen Z, Bradel-Tretheway B, Sumagin S, Bidlack JM, Dewhurst S. "The human herpesvirus 6 G protein-coupled receptor homolog U51 positively regulates virus replication and enhances cell-cell fusion in vitro." Journal of virology.. 2005 Sep 0; 79(18):11914-24.
Wentland MP, Sun X, Bu Y, Lou R, Cohen DJ, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 3: 8-Thiocarboxamido and 8-thioformamido derivatives of cyclazocine." Bioorganic & medicinal chemistry letters.. 2005 May 16; 15(10):2547-51.
Wentland MP, Lu Q, Lou R, Bu Y, Knapp BI, Bidlack JM. "Synthesis and opioid receptor binding properties of a highly potent 4-hydroxy analogue of naltrexone." Bioorganic & medicinal chemistry letters.. 2005 Apr 15; 15(8):2107-10.
Stevenson GW, Wentland MP, Bidlack JM, Mello NK, Negus SS. "Effects of the mixed-action kappa/mu opioid agonist 8-carboxamidocyclazocine on cocaine- and food-maintained responding in rhesus monkeys." European journal of pharmacology.. 2004 Dec 15; 506(2):133-41.
Zhen Z, Bradel-Tretheway BG, Dewhurst S, Bidlack JM. "Transient overexpression of kappa and mu opioid receptors using recombinant adenovirus vectors." Journal of neuroscience methods.. 2004 Jul 30; 136(2):133-9.
Csutoras C, Zhang A, Bidlack JM, Neumeyer JL. "An investigation of the N-demethylation of 3-deoxymorphine and the affinity of the alkylation products to mu, delta, and kappa receptors." Bioorganic & medicinal chemistry.. 2004 May 15; 12(10):2687-90.
Gekker G, Hu S, Wentland MP, Bidlack JM, Lokensgard JR, Peterson PK. "Kappa-opioid receptor ligands inhibit cocaine-induced HIV-1 expression in microglial cells." The Journal of pharmacology and experimental therapeutics.. 2004 May 0; 309(2):600-6. Epub 2004 Feb 02.
Zhang A, Xiong W, Hilbert JE, DeVita EK, Bidlack JM, Neumeyer JL. "2-aminothiazole-derived opioids. Bioisosteric replacement of phenols." Journal of medicinal chemistry.. 2004 Apr 8; 47(8):1886-8.
Rusovici DE, Negus SS, Mello NK, Bidlack JM. "Kappa-opioid receptors are differentially labeled by arylacetamides and benzomorphans." European journal of pharmacology.. 2004 Feb 6; 485(1-3):119-25.
Zhang A, Xiong W, Bidlack JM, Hilbert JE, Knapp BI, Wentland MP, Neumeyer JL. "10-Ketomorphinan and 3-substituted-3-desoxymorphinan analogues as mixed kappa and micro opioid ligands: synthesis and biological evaluation of their binding affinity at opioid receptors." Journal of medicinal chemistry.. 2004 Jan 1; 47(1):165-74.
Bidlack JM, Parkhill AL. "Assay of G protein-coupled receptor activation of G proteins in native cell membranes using [35S]GTP gamma S binding." Methods in molecular biology.. 2004 237:135-43.
Neumeyer JL, Zhang A, Xiong W, Gu XH, Hilbert JE, Knapp BI, Negus SS, Mello NK, Bidlack JM. "Design and synthesis of novel dimeric morphinan ligands for kappa and micro opioid receptors." Journal of medicinal chemistry.. 2003 Nov 20; 46(24):5162-70.
Zhou Q, Duan WH, Cohen DJ, Bidlack JM, Wentland MP. "Synthesis and pharmacology of 8-amino-3-[(tetrahydro-2-furanyl)methyl] benzomorphan." Yao xue xue bao = Acta pharmaceutica Sinica.. 2003 Oct 0; 38(10):748-53.
Kuehne ME, He L, Jokiel PA, Pace CJ, Fleck MW, Maisonneuve IM, Glick SD, Bidlack JM. "Synthesis and biological evaluation of 18-methoxycoronaridine congeners. Potential antiaddiction agents." Journal of medicinal chemistry.. 2003 Jun 19; 46(13):2716-30.
Wentland MP, Sun X, Ye Y, Lou R, Bidlack JM. "Redefining the structure-activity relationships of 2,6-methano-3-benzazocines. Part 2: 8-formamidocyclazocine analogues." Bioorganic & medicinal chemistry letters.. 2003 Jun 2; 13(11):1911-4.
Bowen CA, Negus SS, Zong R, Neumeyer JL, Bidlack JM, Mello NK. "Effects of mixed-action kappa/mu opioids on cocaine self-administration and cocaine discrimination by rhesus monkeys." Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology.. 2003 Jun 0; 28(6):1125-39. Epub 2003 Mar 05.
Wentland MP, Ye Y, Cioffi CL, Lou R, Zhou Q, Xu G, Duan W, Dehnhardt CM, Sun X, Cohen DJ, Bidlack JM. "Syntheses and opioid receptor binding affinities of 8-amino-2,6-methano-3-benzazocines." Journal of medicinal chemistry.. 2003 Feb 27; 46(5):838-49.
Negus SS, Bidlack JM, Mello NK, Furness MS, Rice KC, Brandt MR. "Delta opioid antagonist effects of buprenorphine in rhesus monkeys." Behavioural pharmacology.. 2002 Nov 0; 13(7):557-70.
Parkhill AL, Bidlack JM. "Several delta-opioid receptor ligands display no subtype selectivity to the human delta-opioid receptor." European journal of pharmacology.. 2002 Sep 20; 451(3):257-64.
Bidlack JM, Cohen DJ, McLaughlin JP, Lou R, Ye Y, Wentland MP. "8-Carboxamidocyclazocine: a long-acting, novel benzomorphan." The Journal of pharmacology and experimental therapeutics.. 2002 Jul 0; 302(1):374-80.
Neumeyer JL, Gu XH, van Vliet LA, DeNunzio NJ, Rusovici DE, Cohen DJ, Negus SS, Mello NK, Bidlack JM. "Mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine abuse: synthesis and opioid receptor binding affinity of N-substituted derivatives of morphinan." Bioorganic & medicinal chemistry letters.. 2001 Oct 22; 11(20):2735-40.
Suzuki S, Chuang LF, Doi RH, Bidlack JM, Chuang RY. "Kappa-opioid receptors on lymphocytes of a human lymphocytic cell line: morphine-induced up-regulation as evidenced by competitive RT-PCR and indirect immunofluorescence." International immunopharmacology.. 2001 Sep 0; 1(9-10):1733-42.
Wentland MP, Lou R, Dehnhardt CM, Duan W, Cohen DJ, Bidlack JM. "3-Carboxamido analogues of morphine and naltrexone. synthesis and opioid receptor binding properties." Bioorganic & medicinal chemistry letters.. 2001 Jul 9; 11(13):1717-21.
Peterson PK, Gekker G, Lokensgard JR, Bidlack JM, Chang AC, Fang X, Portoghese PS. "Kappa-opioid receptor agonist suppression of HIV-1 expression in CD4+ lymphocytes." Biochemical pharmacology.. 2001 May 1; 61(9):1145-51.
Wentland MP, Lou R, Ye Y, Cohen DJ, Richardson GP, Bidlack JM. "8-Carboxamidocyclazocine analogues: redefining the structure-activity relationships of 2,6-methano-3-benzazocines." Bioorganic & medicinal chemistry letters.. 2001 Mar 12; 11(5):623-6.
Martin-Kleiner I, Bidlack JM. "Chronic opioid treatment of the mouse thymoma cell lines R1.G1 and R1EGO leads to down-regulation of the kappa opioid receptor without desensitization of adenylyl cyclase activity." International immunopharmacology.. 2001 Jan 0; 1(1):13-20.
Bidlack JM, Abraham MK. "Mitogen-induced activation of mouse T cells increases kappa opioid receptor expression." Advances in experimental medicine and biology.. 2001 493:103-10.
Wentland MP, Duan W, Cohen DJ, Bidlack JM. "Selective protection and functionalization of morphine: synthesis and opioid receptor binding properties of 3-amino-3-desoxymorphine derivatives." Journal of medicinal chemistry.. 2000 Sep 21; 43(19):3558-65.
Bidlack JM. "Detection and function of opioid receptors on cells from the immune system." Clinical and diagnostic laboratory immunology.. 2000 Sep 0; 7(5):719-23.
Neumeyer JL, Mello NK, Negus SS, Bidlack JM. "Kappa opioid agonists as targets for pharmacotherapies in cocaine abuse." Pharmaceutica acta Helvetiae. 2000 Mar 0; 74(2-3):337-44.
Wentland MP, Xu G, Cioffi CL, Ye Y, Duan W, Cohen DJ, Colasurdo AM, Bidlack JM. "8-Aminocyclazocine analogues: synthesis and structure-activity relationships." Bioorganic & medicinal chemistry letters.. 2000 Jan 17; 10(2):183-7.
Neumeyer JL, Bidlack JM, Zong R, Bakthavachalam V, Gao P, Cohen DJ, Negus SS, Mello NK. "Synthesis and opioid receptor affinity of morphinan and benzomorphan derivatives: mixed kappa agonists and mu agonists/antagonists as potential pharmacotherapeutics for cocaine dependence." Journal of medicinal chemistry.. 2000 Jan 13; 43(1):114-22.
Bidlack JM, McLaughlin JP, Wentland MP. "Partial opioids. Medications for the treatment of pain and drug abuse." Annals of the New York Academy of Sciences.. 2000 909:1-11.
Bidlack JM, Jadrovski I. "Pharmacological profiles of kappa opioids. Correlation between [35S]GTP gamma S binding and cyclic AMP production." Annals of the New York Academy of Sciences.. 2000 909:264.
Xie W, Samoriski GM, McLaughlin JP, Romoser VA, Smrcka A, Hinkle PM, Bidlack JM, Gross RA, Jiang H, Wu D. "Genetic alteration of phospholipase C beta3 expression modulates behavioral and cellular responses to mu opioids." Proceedings of the National Academy of Sciences of the United States of America.. 1999 Aug 31; 96(18):10385-90.
Ignatowski TA, Bidlack JM. "Differential kappa-opioid receptor expression on mouse lymphocytes at varying stages of maturation and on mouse macrophages after selective elicitation." The Journal of pharmacology and experimental therapeutics.. 1999 Aug 0; 290(2):863-70.
McLaughlin JP, Hill KP, Jiang Q, Sebastian A, Archer S, Bidlack JM. "Nitrocinnamoyl and chlorocinnamoyl derivatives of dihydrocodeinone: in vivo and in vitro characterization of mu-selective agonist and antagonist activity." The Journal of pharmacology and experimental therapeutics.. 1999 Apr 0; 289(1):304-11.
Martin-Kleiner I, Bidlack JM. "The synthetic kappa-opioid agonist (-)U50,488 does not affect calcium transport into R1.1 mouse thymoma cell line." International journal of immunopharmacology.. 1999 Feb 0; 21(2):133-40.
Dooley CT, Ny P, Bidlack JM, Houghten RA. "Selective ligands for the mu, delta, and kappa opioid receptors identified from a single mixture based tetrapeptide positional scanning combinatorial library." The Journal of biological chemistry.. 1998 Jul 24; 273(30):18848-56.
Sharp BM, Roy S, Bidlack JM. "Evidence for opioid receptors on cells involved in host defense and the immune system." Journal of neuroimmunology.. 1998 Mar 15; 83(1-2):45-56.
Xu JY, Hill KP, Bidlack JM. "The nitric oxide/cyclic GMP system at the supraspinal site is involved in the development of acute morphine antinociceptive tolerance." The Journal of pharmacology and experimental therapeutics.. 1998 Jan 0; 284(1):196-201.
Ignatowski TA, Bidlack JM. "Detection of kappa opioid receptors on mouse thymocyte phenotypic subpopulations as assessed by flow cytometry." The Journal of pharmacology and experimental therapeutics.. 1998 Jan 0; 284(1):298-306.
Ignatowski TA, Bidlack JM. "Changes in kappa opioid receptor expression during maturation of mouse lymphocytes." Advances in experimental medicine and biology.. 1998 437:117-24.
Lawrence DM, Hutchinson I, Seyed-Mozaffari A, Archer S, Bidlack JM. "Fluorescent staining of kappa opioid receptors using naltrexamine derivatives and phycoerythrin." Journal of immunological methods.. 1997 Feb 28; 201(2):173-81.
McLaughlin JP, Sebastian A, Archer S, Bidlack JM. "14 beta-Chlorocinnamoylamino derivatives of metopon: long-term mu-opioid receptor antagonists." European journal of pharmacology.. 1997 Feb 12; 320(2-3):121-9.
Xu JY, Seyed-Mozaffari A, Archer S, Bidlack JM. "N-cyclobutylmethyl analog of normorphinone, N-CBM-TAMO: a short-term opioid agonist and long-term Mu-selective irreversible opioid antagonist." The Journal of pharmacology and experimental therapeutics.. 1996 Nov 0; 279(2):539-47.
Archer S, Glick SD, Bidlack JM. "Cyclazocine revisited." Neurochemical research.. 1996 Nov 0; 21(11):1369-73.
Gatch MB, Negus SS, Mello NK, Archer S, Bidlack JM. "Effects of the structurally novel opioid 14 alpha, 14' beta-[dithiobis [(2-oxo-2,1-ethanediyl)imino]]bis(7,8-dihydromorphinone) on schedule-controlled behavior and thermal nociception in rhesus monkeys." The Journal of pharmacology and experimental therapeutics.. 1996 Sep 0; 278(3):1282-9.
Chao CC, Gekker G, Hu S, Sheng WS, Shark KB, Bu DF, Archer S, Bidlack JM, Peterson PK. "kappa opioid receptors in human microglia downregulate human immunodeficiency virus 1 expression." Proceedings of the National Academy of Sciences of the United States of America.. 1996 Jul 23; 93(15):8051-6.
Schultz AG, Wang A, Alva C, Sebastian A, Glick SD, Deecher DC, Bidlack JM. "Asymmetric syntheses, opioid receptor affinities, and antinociceptive effects of 8-amino-5,9-methanobenzocyclooctenes, a new class of structural analogues of the morphine alkaloids." Journal of medicinal chemistry.. 1996 May 10; 39(10):1956-66.
Bidlack JM, Lawrence DM, Ignatowski TA. "Kappa Opioid receptors on immune cells as studied by fluorescent ligands." Advances in experimental medicine and biology.. 1996 402:13-22.
Liu-Chen LY, Bidlack JM, Rogers TJ, Klein TW, Madden JJ, Sharp BM, Evans CJ. "Molecular and biochemical evidence for receptors for drugs of abuse on immune cells." NIDA research monograph.. 1996 162:37-9.
McLaughlin JP, Nowak D, Sebastian A, Schultz AG, Archer S, Bidlack JM. "Metopon and two unique derivatives: affinity and selectivity for the multiple opioid receptors." European journal of pharmacology.. 1995 Dec 27; 294(1):201-6.
Jiang Q, Seyed-Mozaffari A, Sebastian A, Archer S, Bidlack JM. "Preventing morphine antinociceptive tolerance by irreversible mu opioid antagonists before the onset of their antagonism." The Journal of pharmacology and experimental therapeutics.. 1995 May 0; 273(2):680-8.
Joseph DB, Bidlack JM. "The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line down-regulates without desensitizing during chronic opioid exposure." The Journal of pharmacology and experimental therapeutics.. 1995 Mar 0; 272(3):970-6.
Lawrence DM, el-Hamouly W, Archer S, Leary JF, Bidlack JM. "Identification of kappa opioid receptors in the immune system by indirect immunofluorescence." Proceedings of the National Academy of Sciences of the United States of America.. 1995 Feb 14; 92(4):1062-6.
Lawrence DM, Joseph DB, Bidlack JM. "Kappa opioid receptors expressed on three related thymoma cell lines. Differences in receptor-effector coupling." Biochemical pharmacology.. 1995 Jan 6; 49(1):81-9.
Lawrence DM, Archer S, Bidlack JM. "Identification of opioid receptors in the immune system using a novel combination of selective opioid ligands and indirect phycoerythrin immunofluorescence." Advances in experimental medicine and biology.. 1995 373:17-21.
Bidlack JM, Joseph DB, Lawrence DM. "Kappa opioid receptors on three related thymoma cell lines. Differences in receptor-effector coupling." Advances in experimental medicine and biology.. 1995 373:23-7.
Dooley CT, Kaplan RA, Chung NN, Schiller PW, Bidlack JM, Houghten RA. "Six highly active mu-selective opioid peptides identified from two synthetic combinatorial libraries." Peptide research. 1995 8(3):124-37.
Dooley CT, Chung NN, Wilkes BC, Schiller PW, Bidlack JM, Pasternak GW, Houghten RA. "An all D-amino acid opioid peptide with central analgesic activity from a combinatorial library." Science.. 1994 Dec 23; 266(5193):2019-22.
Archer S, Seyed-Mozaffari A, Jiang Q, Bidlack JM. "14 alpha,14' beta-[Dithiobis[(2-oxo-2,1-ethanediyl)imino]]bis (7,8-dihydromorphinone) and 14 alpha,14' beta-[dithiobis[(2-oxo-2,1- ethanediyl)imino]]bis[7,8-dihydro-N-(cyclopropylmethyl)normorphinone]: chemistry and opioid binding properties." Journal of medicinal chemistry.. 1994 May 27; 37(11):1578-85.
Joseph DB, Bidlack JM. "The kappa-opioid receptor expressed on the mouse lymphoma cell line R1.1 contains a sulfhydryl group at the binding site." European journal of pharmacology.. 1994 Mar 15; 267(1):1-6.
Jiang Q, Sebastian A, Archer S, Bidlack JM. "5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone and its corresponding N-cyclopropylmethyl analog, N-cyclopropylmethylnor-5 beta-methyl-14 beta-(p-nitrocinnamoylamino)- 7,8-dihydromorphinone: mu-selective irreversible opioid antagonists." The Journal of pharmacology and experimental therapeutics.. 1994 Mar 0; 268(3):1107-13.
Sebastian A, Bidlack JM, Jiang Q, Deecher D, Teitler M, Glick SD, Archer S. "14 beta-[(p-nitrocinnamoyl)amino]morphinones, 14 beta-[(p-nitrocinnamoyl)amino]-7,8-dihydromorphinones, and their codeinone analogues: synthesis and receptor activity." Journal of medicinal chemistry.. 1993 Oct 15; 36(21):3154-60.
Lawrence DM, Bidlack JM. "The kappa opioid receptor expressed on the mouse R1.1 thymoma cell line is coupled to adenylyl cyclase through a pertussis toxin-sensitive guanine nucleotide-binding regulatory protein." The Journal of pharmacology and experimental therapeutics.. 1993 Sep 0; 266(3):1678-83.
Jiang Q, Seyed-Mozaffari A, Archer S, Bidlack JM. "Antinociceptive evaluation of 14 beta-(bromoacetamido)-7,8-dihydro- N(cyclopropylmethyl)-normorphinone in mice." European journal of pharmacology.. 1993 Aug 24; 240(2-3):201-6.
Bidlack JM, Kaplan RA, Subbramanian RA, Seyed-Mozaffari A, Archer S. "Affinity labeling of the mu opioid receptor in bovine striatal membranes with [3H]-14 beta-(bromoacetamido)-7,8-dihydromorphine." Biochemistry.. 1993 Jul 6; 32(26):6703-11.
Jiang Q, Seyed-Mozaffari A, Archer S, Bidlack JM. "Pharmacological study of 14 beta-(thioglycolamido)-7,8-dihydro-N(cyclopropylmethyl)-normor phinone (N-CPM-TAMO)." The Journal of pharmacology and experimental therapeutics.. 1993 Mar 0; 264(3):1021-7.
Jiang Q, Sebastian A, Archer S, Bidlack JM. "5 beta-Methyl-14 beta-(p-nitrocinnamoylamino)-7,8-dihydromorphinone: a long-lasting mu-opioid receptor antagonist devoid of agonist properties." European journal of pharmacology.. 1993 Jan 5; 230(1):129-30.
Lawrence DM, Bidlack JM. "Kappa opioid binding sites on the R1.1 murine lymphoma cell line: sensitivity to cations and guanine nucleotides." Journal of neuroimmunology.. 1992 Dec 0; 41(2):223-30.
Bidlack JM, Saripalli LD, Lawrence DM. "kappa-Opioid binding sites on a murine lymphoma cell line." European journal of pharmacology.. 1992 Nov 2; 227(3):257-65.
Selley DE, Bidlack JM. "Effects of beta-endorphin on mu and delta opioid receptor-coupled G-protein activity: low-Km GTPase studies." The Journal of pharmacology and experimental therapeutics.. 1992 Oct 0; 263(1):99-104.
Gucker S, Bidlack JM. "Protein kinase C activation increases the rate and magnitude of agonist-induced delta-opioid receptor down-regulation in NG108-15 cells." Molecular pharmacology.. 1992 Oct 0; 42(4):656-65.
Jiang Q, Seyed-Mozaffari A, Archer S, Bidlack JM. "Antinociceptive properties of two alkylating derivatives of morphinone: 14 beta-(thioglycolamido)-7,8-dihydromorphinone (TAMO) and 14 beta-(bromoacetamido)-7,8-dihydromorphinone (H2BAMO)." The Journal of pharmacology and experimental therapeutics.. 1992 Aug 0; 262(2):526-31.
Hemmick LM, Bidlack JM. "Endorphin peptides enhance mitogen-induced T cell proliferation which has been suppressed by prostaglandins." Advances in experimental medicine and biology.. 1991 288:211-4.
Grandy DK, Hanneman E, Bunzow J, Shih M, Machida CA, Bidlack JM, Civelli O. "Purification, cloning, and tissue distribution of a 23-kDa rat protein isolated by morphine affinity chromatography." Molecular endocrinology.. 1990 Sep 0; 4(9):1370-6.
Bidlack JM, Frey DK, Kaplan RA, Seyed-Mozaffari A, Archer S. "Affinity labeling of mu opioid receptors by sulfhydryl alkylating derivatives of morphine and morphinone." Molecular pharmacology.. 1990 Jan 0; 37(1):50-9.
Bidlack JM, Hemmick LM. "Morphine enhancement of mitogen-induced T-cell proliferation." Progress in clinical and biological research.. 1990 328:405-8.
Hemmick LM, Bidlack JM. "Beta-endorphin stimulates rat T lymphocyte proliferation." Journal of neuroimmunology.. 1990 29(1-3):239-48.
Selley DE, Bidlack JM. "Guanine nucleotide regulation of [125I]beta-endorphin binding to NG108-15 and SK-N-SH cell membranes: specific cation requirements." Brain research.. 1989 Jul 24; 493(1):23-32.
Hemmick LM, Bidlack JM. "Beta-endorphin suppresses rat plaque-forming cell response by a non-opioid mechanism." Journal of neuroimmunology.. 1989 Jun 0; 23(1):67-71.
Bidlack JM, Frey DK, Seyed-Mozaffari A, Archer S. "14 beta-(Bromoacetamido)morphine irreversibly labels mu opioid receptors in rat brain membranes." Biochemistry.. 1989 May 16; 28(10):4333-9.
Bidlack JM, Frey DK, Seyed-Mozaffari A, Archer S. "Irreversible affinity ligands for mu opioid receptors." NIDA research monograph.. 1989 95:296.
Selley DE, Bidlack JM. "Cation requirement for GTP regulation of [125I]b-endorphin binding to Mu and sigma opioid receptors." NIDA research monograph.. 1989 95:537-8.
Tyler CB, Bidlack JM. "Inhibition of (+)[3H]SKF 10,047 binding to rat brain membranes by FAB fragments from a monoclonal antibody directed against the opioid receptor." Neurochemical research.. 1988 Aug 0; 13(8):729-35.
Selley DE, Tyler CB, Bidlack JM. "Guanine nucleotide regulation of [125I]beta-endorphin binding to rat brain membranes: monovalent cation requirement." Journal of neurochemistry.. 1988 Jun 0; 50(6):1844-50.
Bidlack JM, O'Malley WE, Schulz R. "Comparison of [125I]beta-endorphin binding to rat brain and NG108-15 cells using a monoclonal antibody directed against the opioid receptor." Molecular pharmacology.. 1988 Feb 0; 33(2):170-7.
Hemmick LM, Bidlack JM. "Beta-endorphin modulation of mitogen-stimulated calcium uptake by rat thymocytes." Life sciences.. 1987 Oct 19; 41(16):1971-8.
Bidlack JM, O'Malley WE. "Inhibition of mu and delta but not kappa opioid binding to membranes by Fab fragments from a monoclonal antibody directed against the opioid receptor." The Journal of biological chemistry.. 1986 Dec 5; 261(34):15844-9.
Bidlack JM, Mabie PC. "Preparation of Fab fragments from a mouse monoclonal IgM." Journal of immunological methods.. 1986 Jul 24; 91(2):157-62.
Rudick RA, Pallant A, Bidlack JM, Herndon RM. "Free kappa light chains in multiple sclerosis spinal fluid." Annals of neurology.. 1986 Jul 0; 20(1):63-9.
Bidlack JM. "Binding to mu and delta opioid sites but not kappa sites is inhibited by Fab fragments from a monoclonal antibody directed against the opioid receptor." NIDA research monograph.. 1986 75:21-4.
Bidlack JM, Denton RR. "A monoclonal antibody capable of modulating opioid binding to rat neural membranes." The Journal of biological chemistry.. 1985 Dec 15; 260(29):15655-61.
Rudick RA, Peter DR, Bidlack JM, Knutson DW. "Multiple sclerosis: free light chains in cerebrospinal fluid." Neurology.. 1985 Oct 0; 35(10):1443-9.
Rudick RA, Bidlack JM, Knutson DW. "Multiple sclerosis. Cerebrospinal fluid immune complexes that bind C1q." Archives of neurology.. 1985 Sep 0; 42(9):856-8.
Bidlack JM, Denton RR. "A monoclonal antibody directed against an opiate binding site in rat neural membranes." Neuropeptides.. 1984 Dec 0; 5(1-3):225-8.
Harwell LW, Bolognino M, Bidlack JM, Knapp RJ, Lord EM. "A freezing method for cell fusions to distribute and reduce labor and permit more thorough early evaluation of hybridomas." Journal of immunological methods.. 1984 Jan 20; 66(1):59-67.
Archer S, Seyed-Mozaffari A, Osei-Gyimah P, Bidlack JM, Abood LG. "14 beta-(2-bromoacetamido)morphine and 14 beta-(2-bromoacetamido)morphinone." Journal of medicinal chemistry.. 1983 Dec 0; 26(12):1775-7.
Bidlack JM, Abood LG. "Molecular characteristics of brain opiate and nicotine receptors." Biomembranes. 1983 11:415-37.
Bidlack JM, Denton RR, Harwell LW. "Generating monoclonal antibodies to the opioid receptor." Life sciences.. 1983 33 Suppl 1:151-4.
Bidlack JM, Ambudkar IS, Shamoo AE. "Purification of phospholamban, a 22,000-dalton protein from cardiac sarcoplasmic reticulum that is specifically phosphorylated by cyclic AMP-dependent protein kinase." The Journal of biological chemistry.. 1982 Apr 25; 257(8):4501-6.
Bidlack JM, Abood LG, Munemitsu SM, Archer S, Gala D, Kreilick RW. "Affinity labeling and purification of the opiate receptor from rat brain." Advances in biochemical psychopharmacology. 1982 33:301-9.
Bidlack JM, Abood LG, Osei-Gyimah P, Archer S. "Purification of the opiate receptor from rat brain." Proceedings of the National Academy of Sciences of the United States of America.. 1981 Jan 0; 78(1):636-9.
Abood LG, Reynolds DT, Booth H, Bidlack JM. "Sites and mechanisms for nicotine's action in the brain." Neuroscience and biobehavioral reviews.. 1981 5(4):479-86.
Abood LG, Reynolds DT, Bidlack JM. "Stereospecific 3H-nicotine binding to intact and solubilized rat brain membranes and evidence for its noncholinergic nature." Life sciences.. 1980 Oct 6; 27(14):1307-14.
Bidlack JM, Shamoo AE. "Adenosine 3',5'-monophosphate-dependent phosphorylation of a 6000 and a 22,000 dalton protein from cardiac sarcoplasmic reticulum." Biochimica et biophysica acta.. 1980 Oct 1; 632(2):310-25.
Bidlack JM, Abood LG. "Solubilization of the opiate receptor." Life sciences.. 1980 Jul 28; 27(4):331-40.
Bidlack JM, Lockshin RA. "Evolution of LDH isozymes during programmed cell death." Comparative biochemistry and physiology. B, Comparative biochemistry.. 1976 55(2):161-6.
Author List: Bidlack, J.M., and Mathews, J.L.
Chapter Title: Review of Carleton K. Erickson. The Science of Addiction: From Neurobiology to Treatment.


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US to Canada by car with an enhanced driver's license, no passport? Also, it's only 26 episodes long, making it ideal for binge watching. While the franchise is often based on a manga, the TV series and the real-life game(s) tend to play a more prominent role in its popularization.[2].
Echo! What are the purpose of the extra diodes in this peak detector circuit (LM1815)? I remember he was very serious all the time, the show in general was very serious, no comedy like other card game shows such as yu-gi-oh, I'm pretty sure it was the intention of the creators to make a serious anime to this genre as the market was flooded with light hearted silly card based animes at the time. Very! *bong*, she's actually fighting for her life in every match and acts accordingly, Summoning mystical, talking animals is one of the many varieties of Ninjutsu magic used in, Because part 3 of the manga, Stardust Crusaders, predates most of the examples in this category it can be considered the. I probably watched the anime anywhere from 6 to 10 years ago, it's hard to recall, from what I remember it was about a boy, probably anywhere from 14 years of age to older, had shorter to medium spikey hair, not as outlandishly spikey as vegetas, but more semi realistic, I'm not to sure on the hair color, I cant recall. Out of the original three "Mon" franchises, Monster Rancher is the most forgotten one and is usually only mentioned mockingly. Wise! And before I forget, because creatures are often based on the same collection of commonly known tropical/prehistoric/mythological wildlife, there are a great deal of similar critters across different franchises. However, depending on who you are and where you live, you also may remember fondly watching one of these Pokemon anime rip-offs. The most ridiculous thing about this anime, though, is the kid named Rex Owen. The show focused on a group of trainers battling monsters made with alien and animal DNA that they keep in devices called Cores. Thus begins a life-changing journey through the wonderful world of [Insert name of franchise here]. Nintendo has also taken some of its JRPG's in this direction; Although it's not a Mon series, per se, both, The Cyber-Elf gathering and utilization system introduced in the, In the third installment, you can collect viruses that can be summoned to perform a single attack while in battle. When the Pokemon anime first aired in 1997, it took what was already a best-selling formula in the video game world and increased the popularity tenfold and made Pokemon a global phenomenon. Fumizuki Academy isn't a typical Japanese high school. On the bright side, his friend Yuuji Sakamoto is in the same class, and to everyone's surprise, the genius girl Mizuki Himeji has also ended up in the same class due to an unforeseen fever on the day of the test. Tell your friends! [7] The episode starts out in an environment familiar to the protagonist, but soon the protagonist and the viewers along with him are drawn into the world of [Insert name of franchise here] and a challenger appears. Support The series is more mature than most of the other entries on this list, as protagonist Mai Tokiha discovers she and the other HiMEs were gathered to Fuka Academy for a secret purpose. Does anyone remember this old "trapped in a video game" anime?
Sitemap, Calling all otaku! The first one is usually referred to as evolution, even though that word meant "gradual change over time"[15] in a distant past where this genre wasn't universally popular yet. The go-to source for comic book and superhero movie fans. See also The Beastmaster and Bond Creatures. By logging in to LiveJournal using a third-party service you accept LiveJournal's User agreement, Shadows of Hyperion is now up! Likewise, said Warcasters can also get very defensive about particular 'Jacks as well (case and point - this is the reason Haley refuses to have Cygnarian Mechanics "examine" Thorn). Not to Be Confused with mon, a historical currency in Japan, mon, a Japanese symbol similar to a coat of arms in European heraldry, a Belgian city, or the mons veneris, for that matter. Speaking of which, the franchise's universe will contain a load of creatures, often referred to as monsters regardless of how monster-like they actually are, which will be forced to battle each other because these battles constitute the most popular sport of the franchise's world[13] and/or because for some reason the fate of the entire world depends on the outcome of these battles. Covering the hottest movie and TV topics that fans want. In the first couple episodes, the gang establishes their goal[12]: becoming the best, fighting evil forces, or in the best case, both. Joe action figures, anime in the early 2000s had us collecting virtual pets and trading cards. The series starts by introducing the viewers to the main protagonist, a regular kid, usually pretty naive, not exceptionally smart but certainly not stupid either, invariably an intuitive and forthcoming person with strong ideals who looks rather carefree most of the time, but when things get serious, he[6] gets this really determined look in his eyes. The various character's personalities all have some sort of specific trait which an experienced anime watcher may recognize, to an extent. To subscribe to this RSS feed, copy and paste this URL into your RSS reader. Without warning, Sanshiro is taken to a backwards universe to play It's hard to remember, but I want to say he was short in stature, may e black hair and had serious looking eyes, he wasnt a very light hearted character, which is what leads me to believe he may have been in his mid to late teens, there really wasnt a lot of comedy in the series if anything despite it seeming like it was for kids, maybe it wasnt. Privacy The main characters eyes weren't so large and animeish, they were smaller and more serious looking is the only way I can describe it, but still anime eyes, just not the huge large ones like in the example above, almost more like attack on titan eyes if that makes sense, more realistic in a sense. Now combine all of that with insect collecting, virtual pets, cockfights and the desire to make loads of money and you get this genre. This allows characters to fight each other without actually fighting themselves; instead, they conjure an avatarperhaps a beast or a machinethat fights for them. Taking place in another world known as the Moonlands, the long-sealed evil Shadow Magi Agram plans to escape and bring the Moonlands under his control, and it's up to a group of kids and their Dream Creatures to stop him. There's no room for inbetweeners. Reach her on Twitter (@TalkToGabrielle) or by email (gabrielle.h@thegamer.com). When tropes are overdone, they become stale. And then there's the giant monsters these mecha have to face in certain series. They were pretty disjoint from the main series, so could easily be remembered as a separate franchise entirely. Combing the Pokemon formula with the magical girl genre, My-HiME focuses on a group of girls with the power to summon and control Children: part-spiritual, part-magical creatures. Based on a card-based arcade game by Sega, Dinosaur King was adapted into an anime in 2007, making it a pretty late Pokemon knockoff. Also, due to the fact that it is an American franchise[22], the mother of all trading card games, Magic: The Gathering, doesn't have its own anime. Although this is the second series to be based off the Zoids mecha models, Zoids: New Century was the first to be dubbed in English and air on Western television. Terms Favorite Question and Answers from Second Quarter 2022. If they are strangers to the protagonist, chances are they start out as adversaries, but quickly bond and become friends.
Incidentally, what class you are in correlates to the facilities they have, much like an academic caste system. Unfortunately for Akihisa Yoshii, his supposedly "great" intellect wasn't quite enough for such a test, and he's now stuck at the bottom of F class. The second of the original "Mon" franchises and the biggest competitor to Pokemon at the time, Digimon is probably the first name you think of when you read "Pokemon Anime Rip Off." I also remember wind played a big deal I think with the story or the main character, maybe that's why I remember the wind blowing and the wind turbine so prominently in the final episode. A Monnoteshort for "monster", as in Pokmon (Pocket Monsters) and Digimon (Digital Monsters) is a creature, generally summoned by magic or sufficiently advanced science means, which fights on behalf of its summoner. What you get is a comedic slice-of-life anime about a boy who sees funny ghosts. As to why Wikipedia will never have an article on it, it's because original thinking is strictly forbidden around those parts. Belle uses what little free time she has to play Guild Wars 2 with her partner, work toward that 5-star rating in Animal Crossing, and wonder when the new Dragon Age installment is coming out. Drago could also be viewed as this to Vladimir Tzepeci, and Beast 09 for Sorcha is most definitely this. This one wasn't very memorable. Instead, they are used in a series of competitions and tournaments run by the Zoid Battle Commission. @AaronChristian You can get rep by posting your own answers and questions and even through suggested edits, however, when editing please do not use it to post your own answer as the edit will generally just be rejected as it was here. Taking place long after Zoids: Chaotic Century, Zoids are no longer used for warfare. obtain the wish that is granted to the winner. The creatures will typically be segregated[14] according to the types/attributes/elements/families/civilizations/whatever you want to call it they're associated with. Site design / logo 2022 Stack Exchange Inc; user contributions licensed under CC BY-SA. And because making anime-like shows is clearly above. It was a little earlier than 10 years ago, but only by a couple of years and you could have watched it a bit later. Without the subtitle, English people might be lead to believe that it's not a movie. Though Digimon was the first big Pokmon copycat, Yu-Gi-Oh! Expect to see lots of alternative family structures among the main characters: one of their parents is mysteriously absent/mysteriously died when they were young, they're being raised by their grandparents, they were adopted, stuff like that. Don't worry, it's not a criminal organization. That's when his childhood friend Maiko introduces him to the titular virtual reality fighting game in which players and their dragon partners face off in a virtual city. Somehow, he is one of the few duelists able to bring the monsters on his cards to life. And that don't belong to the small group of female protagonists. [26], Template:FA/16 September 2012Template:FA/2012Template:FQ/16 September 2012Template:FQ/2012, From Uncyclopedia, the content-free encyclopedia. What would the ancient Romans have called Hercules' Club? This series is filled to the brim with food puns, like the Foodon Hot Doggone-It and the villainous King Gorge. Join the official A Couple of Cuckoos Official MAL Club for your chance to win! Compare and Contrast Cool Pet as well as Summon Magic. Text in table not staying left aligned when I use the set length command. And to keep it family-friendly, these battles practically never result in any deaths. Instead, the monsters faint, turn into an egg or are sent to a gloomy afterlife in the Graveyard. It wouldn't be a proper anime if it didn't have any. [23] Additionally, if there's a great deal of creatures to collect, the protagonist in question will conveniently own a ranch or farm where there's plenty of room to stow away monsters whose services aren't required. Contrary to popular belief, the focus is on the humans for the most part, not the titular Mons, no matter how interesting and sapient the latter are. He eventually unleashes them on the town, killing many, Salamanders are also shown to "evolve" into a more powerful type of demon called drakes when submerged in lava, and drakes apparrently evolve further into, Because reionics are unwittingly carrying out the agenda of a long-defeated, had "caught 'em all" in the past, but then lost 'em, To catch them is my real test, to train them is, Contrary to popular belief, the focus is on the humans for the most part, not the titular Mons, no matter how interesting and sapient the latter are, Tales of Symphonia: Dawn of the New World, but without the top-notch animation due to bad outsourcing, Johnny (and Jakeem) Thunder's Thunderbolt, transforming the vessel into the Material. FAQ Unfortunately, it doesn't look like they've been released outside of Japan. Updated June 24, 2022, by Gabrielle Huston: Many of us remember watching the original Pokemon anime fondly. Wikipedia defines doubleplusgood thinking as the process of thought that adheres to their perennial slogan: World's worst trolling attempt: an abomination unleashed, http://en.uncyclopedia.co/w/index.php?title=Japanese_TV_series_centered_around_battles_where_powerful_creatures_are_summoned_using_some_small_object_that_usually_has_a_real-life_equivalent_of_these_battles_in_the_form_of_a_game,_except_in_real_life,_you_don%27t_actually_get_to_summon_any_creatures&oldid=6154566. No franchise is truly complete until even airplanes have succumbed to the craze. Starting off as a franchise of video games and toys, Yo-Kai Watch has become so popular in Japan that the movie beat The Force Awakens when it premiered in theaters. Expect the majority of Mon works showing the human barely doing any contribution to the fighting while hogging all the Character Development, with the Mons in question being Satellite Characters.
A phrase originally used by circus ringmasters when animals got loose or performers were hurt, signifying that they valued making profit higher than the physical and psychological well-being of human beings. Given the world the series is set in, their intentions are. As the latest brand of anime to attract a worldwide fanbase, its origins must inadvertently lie in older, more established brands of popular Japanese television. Though it's mainly remembered as being a cheap rip off of Yu-Gi-Oh!, Duel Masters was actually pretty popular in Japan, with its manga selling 4.46 million copies in total. Mecha are large mechanical battlesuits, often termed robots despite them being almost indiscriminately piloted by humans[3], which varyingly appear out of underground bases, aerial transports, huge spaceships, but most notably out of thin air. In this new world he's transported to he is controlling real life monsters in battles, most are creature based like dragons and such, but I recall maybe he had a humanoid monster he would summon, that's what made him special, he was the only one or one of few that had humanoid summons. Probably because a translated manga isn't as appealing to children as a TV series or a video/strategy game is. There were also a couple of video games, but none of them were released outside of Japan. TVTropes is licensed under a Creative Commons Attribution-NonCommercial-ShareAlike 3.0 Unported License. Fighting Foodons is a series where all the monsters are living food items. Yeah, for some reason, Nickelodeon waited a long time to produce their "Mon" series, long after stronger competitors like Digimon and Yu-Gi-Oh! Starting off as a manga in Monthly Shonen Jump, Dragon Drive's hero, Reiji Ozora, stands apart from the determined protagonists common in this genre in that he is a lazy slacker that can't finish anything. Likewise, whether they're servants, partners, or just another race depends on the series. Hey k mo, I watched a little bit of bakegyamon to see if it seemed familiar But unfortunately that isnt the anime I was looking for. Regardless the boy is now in this new world battling with these monsters, he may still be using cards in this new world to summon these monsters, I can't remember, and he gets mixed up in a war or conflict in this new world, there is a girl, I can't recall if she is a princess but I believe they end up falling in love, or at least he develops strong feelings for her. rev2022.7.21.42639. with quote/unquote the mentally retarded. Seriously, if the title had four more characters, it would be. As the name implies, this one has kids training and fighting dinosaurs, which are contained in some futuristic cards that are activated when rubbed against some stones from a meteor. These series tend to be less successful as the lack of these objects makes it harder for the fans to identify with the protagonist as they generally lack innate magical abilities and there's no toy or item they can purchase that corresponds to the protagonist's power source to make up for it. For a long time in the late 90s to the early 2000s, it seemed every other anime being shipped out of Japan involved a group of kids collecting powerful monsters to fight with. Which is obviously just to give people someone to identify with when they're playing around with their little Gundam toys.
He was white, and I want to say he had short black hair that was a little spiky standing up, but not ridiculously like vegeta in DBZ, more realistic than that. Capsule Monsters" (a miniseries where they are transported into the Capsule Monsters world)? Monsters will also be able to grow stronger; this occurs varyingly by transforming into a more powerful monster, by leveling up, by absorbing power from other entities or by fusing with another monster. Latest Blog Post: Jacks Bad Movies: Favorite Questions and Answers from Anime: boy spawns down monsters, including a floating eyeball, is saved by an adult from drowning when diving to look for a boat. Also, be prepared for the typically unrealistic anime haircuts; the protagonists that don't wear some kind of headgear[10] almost invariably have Goku hair[11], sometimes with bits of hair in a different, lighter colour in the front. We have the answers to all these questions and more! Abridged series: the only reason why God allowed this type of anime to come into existence in the first place. A character's main Mon is their Signature Mon. RELATED: The Strongest Anime Characters Ever, Officially Ranked. I feel like it was the creators intent to differentiate itself from all the other card based animes of the time, and tried to make an adult serial that wasnt really for kids or people who enjoyed shows like yu-gi-oh. @laurel if I recall I remember a dragon type monster and other creatures similar to that, most of them were monster types like that, but I think there might have actually been a humanoid looking one that was specific to the main character, having that humanoid looking monster attached to him is what made him special, because it was probably one of the o ny if not the only humanoid looking monsters. Shaman King, JoJo's Bizarre Adventure, The Familiar of Zero, Magical Girl Lyrical Nanoha, Bleach and Naruto, occasionally). Even today, more than twenty years later, the anime, video game series, and merchandise are still as popular as ever. RELATED: The Best Battles Of The Pokemon Anime. One notable example is Taomee's. While most of these shows have a protagonist who is trying to "be the very best," Nate is just trying to live a normal life, but all these Yo-Kai (ghosts) keep interrupting his life. May function as a Guardian Entity. Starting off as a manga in Weekly Shonen Jump, the series follows Yugi Mutou who, thanks to his Millennium Puzzle, has an ancient alter-ego that's really good at playing games. The best answers are voted up and rise to the top, Start here for a quick overview of the site, Detailed answers to any questions you might have, Discuss the workings and policies of this site, Learn more about Stack Overflow the company. As the show progresses, new, more threatening antagonists/villains will rear their ugly/sexy heads. This series spawned a few memorable video games, including Dragon Drive: D-Masters Shot on GameCube. fifteen-foot cylopean monstrosity with massive claws, starts collecting wild animals in cages and teaching them to fight. Part of that reason may be due to the anime serving as a parody of Pokmon-type shows. I remember I watched it online and it was subtitled, to my knowledge I'm not sure if it has ever had an English release or dub. Nearly all of these Pokemon clones are made with the idea of selling cards and toys to kids, but Shadow Star instead aimed to deconstruct the entire Pokemon genre. Of course, Japanese studios weren't the only ones looking to copy Pokemon's success. If the initial series proved to be sufficiently popular among the masses, or if some wealthy Japanese guys just feel like throwing away some of their money, follow-up series are bound to ensue. Also a type of Attack Animal. [25] Also, their capitalize-every-word style of titles makes reading very long titles pretty obnoxious. But because the people who summon these dragons tend to be experts at martial arts and can fire energy beams from their hands and because the dragons were gifted with the godlike power to grant wishes, there was no incentive to make use of the dragons' no doubt awesome fighting abilities. Turns out these cards contain powerful creatures called Bakugan. Smart!" And it does throw a few interesting turns at you; like the FFF (christ, I'm still laughing over them) - a cult like the KKK; only that they go after those who have girlfriends (or guys who receive obentou from girls, for that sake). It's either his normal haircut or his Super Saiyan haircut. Source: Scan of the annoread more, Aug 22, 2010 10:54 PM by dtshyk | Discuss (53 comments), Frugal Baka Test Fans versus Silent Queen's Blade Gentlemen, Komoto Sachi, the assistant producer of Baka to Test to Shoukanjuu, gave her analysis on the relationship between the nature of the fanbase and the media sales. If you ever thought Pokmon battles would be cooler with giant robots, this is the series for you. RELATED: Pokemon: Ranking The First Episodes Of The Original Anime. And often whatever container the mecha are in seems disproportionately small compared to the size the mecha have when they're fighting the enemy in a random city littered with skyscrapers[4], for instance. July 2022 Topic Challenge: Nnedi Okorafor. A joint production between Canadian and Japanese studios, Bakugan Battle Brawlers starts when some magical cards just fall out of the sky one day, for no real reason. And then there's the series that don't use any objects to summon powerful creatures. DeviantArt is an imageboard site used primarily for the same purpose, but is even worse since pictures are used instead of words. Is there any chance this is simply "Yu-Gi-Oh! If the protagonist is also trying to win some kind of major tournament at the time, these two events will likely be connected. Do Not Sell My Personal Information He is last seen in his own world on top of a building, possibly a skyscraper, or maybe even just a grassy hill, but pretty sure it was a metal building, I can't remember if he was in a wheel chair or not, with the wind blowing and possibly one of those huge metal wind turbines spinning in the background somewhere, and him swearing he'd make it back to that other world somehow to that girl, or at the very least he was thinking of her as they showed us she was also thinking of him. Gabrielle "Belle" Huston is a writer and long-time gamer based in Ottawa, Canada. [1]. You can nominate your favourite articles at, Fan fiction and perverted DeviantArt 'art'. It's very telling that this series was produced by toy company Jakks Pacific and trading card maker The Topps Company. All the latest gaming news, game reviews and trailers. I'm not entirely sure if there was a card game involved at all but I thought that's how I originally found the anime is by looking for a card game type anime on the internet to watch. Don't let the cute creatures and kiddie opening fool you, as this series shows what would really happen if misfit teenagers could control supernaturally powerful monsters. Monsuno was an American cartoon that aired on Nickelodeon, premiering in 2012. The participants can summon fantasy characterswhose power levels are equal to their student's test scoresin an all-out battle. Played somewhat straight with the Warjacks - if a specific 'Jack is used by a Warcaster frequently for a long period of time, they can gain a level of personality. This site is protected by reCAPTCHA and the Google, by Hitomi Harada, Kaori Mizuhashi, Emiri Katou, and Tomomi Isomura. Lastly, there are also series where monsters are magically summoned by magic users without the use of any small objects (e.g.
Unsatisfied with their perquisites, F class rallies behind Yuuji, determined to take on the higher-tiered classes in order to seize their perks by using the school's Examinations Summon Battle system.
old anime with summoned creatures
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old anime with summoned creatures 2022

redpajama_set_name: RedPajamaCommonCrawl


Call us at (513) 469-2825 today to see what grow room gear we have in stock!
The Tent Hanging brackets will enable you to hang and run a LightRail 3.5 or 4.0 light-mover in your grow tent. The Tent Hanging Brackets are for LightRail and are straight forward and simple to install.
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Select which tickets using the toggle switch. Enter the Low (starting) ticket number (using the page up or page down increases or decreases the number by 20). Repeat for the High (ending) number. The program figures the number of tickets sold.
Click on Start Spinning! Once the spinning starts, the Pick a Number button lights up.
Click on Pick a Number! The last number generated will show in the black box with green numbers.
Choose to pick it or throw it back.
Click on Generate a Score button.Continue to hit the Generate a Score button until a winning score is generated.


At Leisure Traders we like to deliver your order to you swiftly and hassle free. Therefore we have 3 main ways of shipping your goods. Please see below a breakdown of our delivery information.
Our transport team will deliver items weighing approximately up to 30 kilos by using a professional courier service.
We arrange delivery of our larger items, that are not fragile, by a curbside pallet service.
For the larger and fragile products we carry out your delivery by using a professional 2 man service.
Leisure Traders will use a courier service for all customer orders of a small to medium size.
Unless we advise differently in a product listing, we despatch all orders received before 9am on the same day for delivery within 2 working days.
You may experience a small delay in the receipt of your order if we are experiencing a particularly busy period.
The courier driver will require a signature on all deliveries when received.
If you are unable to provide a signature, we can arrange to deliver your order to a neighbour/alternative address.
Alternatively the courier can leave the item in a safe place.
Should you choose to have your order delivered to an agreed safe place, we will not require a signature. However we can take no responsibility for your parcel after the driver leaves it.
Please advise us when placing your order if you have any special instructions for your chosen delivery address.
The courier service will deliver to you between Monday – Friday during 9.00am to 5.00pm.
We are unable to provide time slots for deliveries or a Saturday delivery service.
Whenever the delivery driver finds no-one at the delivery address, they will leave a card giving details for you to re-arrange another delivery.
The driver will make approximately 2 attempts to deliver your order to you and leave a contact card.
If you do not contact them after receiving a contact card the goods come back to our warehouse.
We can arrange another delivery but this will incur a delivery charge.
Please ensure that you check your item at the point of delivery. If damaged, please sign the delivery note 'Damaged' and refuse the delivery. Failure to check your item and sign the delivery note accordingly, will invalidate any claim.
Deliveries of some larger products will be made using a pallet service*.
This service only delivers to the curbside outside your chosen delivery address.
We can arrange for a Saturday or timed delivery at an additional charge.
Once the pallet company has collected your order from our warehouse, it is a 3-5 working day service.
The pallet company will contact you direct to arrange the delivery date and time.
The driver will off-load your delivery onto the curb-side outside your chosen delivery address.
However the driver is unable to take responsibility for unpacking or setting up of the product.
The delivery driver will require a signature upon receipt of all orders.
Should you be unable to sign for an order, we can deliver your order to a neighbour/alternative address.
Alternatively the driver can leave the order in an agreed safe place.
When we deliver your order to a safe place, we will not require a signature.
However we can take no responsibility for your order.
Once we have dispatched your order we will have to make an additional charge for any change of in your chosen delivery address.
For further delivery information on this service please do not hesitate to contact us on 01323 430020.
*Pallet delivery can only be made to addresses on the UK mainland excluding the Highlands and Outer Hebrides. Deliveries outside of this area will take 3-5 working days and we will have to make an additional delivery charge. Please contact us for a quote.
Leisure Traders provides a 2 Man delivery service for larger items that are also fragile. The larger Garden Furniture Sets, for example, fall into this category. We put the safe delivery of our products above that of a speedy delivery and, therefore, we use a 2 man service which can take a little longer.
With this level of delivery service the 2 Man Service will collect your order from our warehouse and deliver to your chosen destination and place it either in your home or garden.
Once the 2 Man service collects your order from our warehouse they will take approximately an average of 14 days until they will deliver to you.
The 2 Man service will contact you direct to arrange a delivery day that suits you both.
We require a signature on all deliveries received.
FREE standard delivery comes will all orders within Mainland UK.
As we use a third party delivery services to dispatch our goods, we may take a little bit longer to deliver to regions that fall outside of mainland UK.
Also we will charge an additional delivery fee to deliver your order that bit further afield.
The following postcodes and regions fall outside of Mail land UK: AB, DD, DG, EH, FK, G, HS, IV, KA, KY, KW, ML, TD, IV, PA, PH , Northern & Republic of Ireland, Isle of Wight, Isle of Scilly, Isle of Man, Shetland and Orkney Islands, Channel Islands, Scottish Islands, the Highlands and Outer Hebrides.
For international deliveries, please enquire for a quote.
Delivery information on all orders that are not part of the Casamoré Furniture range varies from item to item.
Your can find details of the estimated delivery time for each item clearly given on the product information page.
We treat each delivery as important and special and make every effort to ensure that your order arrives with you in perfect condition.
If our delivery service delivers your order in a damaged state we try to resolve all issues as swiftly and efficiently as possible.
Here our Customer Service is ready and waiting to help you in any way during the week days Monday to Friday 9.00am – 5.30pm on 01323 430020. So give us a call if you need have any questions.
Or if you prefer, email us at sales@leisure-traders.co.uk.


text:
using System;
using System.Collections.Generic;
using System.Linq;
using System.Text;
using System.Threading.Tasks;

namespace Yargon.Parsing
{
    /// <summary>
    /// A message about a source file.
    /// </summary>
    public interface IMessage
    {
        /// <summary>
        /// Gets the kind of message.
        /// </summary>
        /// <value>A member of the <see cref="MessageKind"/> enumeration.</value>
        MessageKind Kind { get; }

        /// <summary>
        /// Gets the location of the message.
        /// </summary>
        /// <value>A source range; or <see langword="null"/> when the source range is not known.</value>
        SourceRange? Location { get; }

        /// <summary>
        /// Gets the message text.
        /// </summary>
        /// <value>The message text.</value>
        string Text { get; }
    }
}

redpajama_set_name: RedPajamaGithub


In CG in 4.0 sp1 I could copy text from a PC Bible and then paste it over highlighted text in a cg page and the old text would disappear as expected replaced by the new. In 4.5 when doing a paste it does not replace highlighted text. Is there something in preferences that can be changed to make it happen or is it a bug? Also having word wrap would be nice in CG.
Yes, I can duplicate that here, Rich.
Thanks for pointing this out, and I've notified engineering about this.


text:
Semi Conductor & Solar
Home Shipping & Logistics
How USMCA Could Streamline North American Supply Chains
Now in force, the United States-Mexico Trade Agreement presents new opportunities and challenges for U.S. shippers that are involved with cross-border trade in Canada and Mexico.
This post is also available in: Spanish
In place since 1994, the North America Free Trade Agreement (NAFTA) was the playbook that all shippers involved with cross-border trade in the U.S., Canada, and Mexico worked from. The three-country accord had its supporters and detractors, and was focused on eliminating most tariffs on products traded across the three countries.
With a primary focus on liberalizing trade in agriculture, textiles, and automobile manufacturing, NAFTA also sought to protect intellectual property, establish dispute resolution mechanisms, and implement labor and environmental safeguards.
It's been about two years since the three countries reached an agreement to replace NAFTA with the United States–Mexico–Canada Agreement (USMCA) (NAFTA remained in force until USMCA was implemented). As of July 1, the USMCA effectively replaced NAFTA and went into effect with no transitionary period.
That means U.S. shippers must now follow the new rules of USMCA when shipping to and from Canada and Mexico. Similar rules apply for shippers based in those two countries, although there the pacts are known as the Canada-United States-Mexico Agreement (CUSMA) and Tratado entre México, Estados Unidos y Canadá (T-MEC).
In 2020 Cross-border Update: Even more confusion ahead, Logistics Management outlines some of the differences between USMCA and NAFTA. Pointing to the auto sector, it says the former includes a requirement that by 2023 at least 75% of parts in an automobile must be North American (up from 62% required under NAFTA). The new agreement also stipulates at least 40% of workers in the North American auto supply chain must be paid at least $16 an hour.
There have also been changes to the rules of origin, which could be altered further over the coming months. "That leaves companies to evaluate how the rules of origin, as currently written, impact their operations and also leaves them wondering if they'll need to reevaluate them every time there's an update to the proposed regulations," Logistics Management points out.
Streamlining Supply Chains
The new agreement also presents an opportunity to streamline supply chains across the three North American countries. For example, it nearly eliminates the need for any hardcopy documentation to be presented for customs clearance (i.e., electronic document submissions will be treated equally with paper documents).
"The idea behind the new USMCA is to improve supply chain efficiencies by embracing a more modern, systematic approach and use of information technology that wasn't present in the old NAFTA," it adds, noting that USMCA incorporates new, updated sections on topics such as intellectual property rights, enforcement, digital trade, and labor rights based on the original NAFTA.
"The new agreement addresses many existing cross-border issues and red tape, including what USMCA introduces as the concept of a single window system," Logistics Management points out, "as the original NAFTA didn't address any systematic requirements among the parties."
The High Points
In Gaining Supply-Chain Efficiencies Through Implementation of USMCA, Supply Chain Brain highlights some of the other positives that could come out of the new free trade agreement. For instance, it singles out the increase to the de minimis amount (the threshold at which a shipment can incur a duty or tax) as one benefit for shippers. Here's how it works:
Canada is maintaining a de minimis threshold of at least $150 (CDN) for customs duties and $40 for taxes at the time or point of importation of goods shipped by courier from the United States or Mexico.
For Mexico, there is no change in the original amount of $50 (USD), no duty or taxes payable but adding a level of up to US$117, and no duty payable but subject to taxes.
For the U.S., there was no change to the current $800 level that was put in place back in 2016.
The agreement also emphasizes the need for uniform treatment of imports across ports and border crossings, stating that each party shall apply its customs procedures related to the importation, exportation, and transit of goods in a manner that is transparent, predictable, and consistent throughout its territory.
"As many U.S. importers know, one port might treat a tariff classification or item value differently than another," the publication states, "so the agreement emphasizes the need for ports to work together in the event of a discrepancy."
By setting out modern standards to assist the flow of information for customs clearance, the USMCA lays out a new foundation for shippers, carriers, freight forwarder, and logistics providers. "The next few years should see improvements in these areas for the USMCA trading bloc," Supply Chain Brain concludes.
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The Freya Fancies plunge bra is simple and chic in this gorgeous olive tone. All-over lace is easy to style, offering great mix-and-matchability throughout the range. Laminted lace bottom cups lift and support your bust with underwire, while the lighter lace top cup has a slight stretch for an easy fit. Finished off with sleek cut out details to the gore and band, this light and delicate design really packs a supportive punch!


text:
Mozambique: Prison Guards Trading Female Inmates for Sex at Maputo's women's prison .
By Jorge Joaquim
Inmates at Maputo's women's prison are being sold for sex by prison guards, an investigation by the transparency NGO CIP has found.
Using hidden cameras and posing as clients, CIP researchers paid for meetings with women who testified that they were regularly taken out of the prison to have sex with clients — or beaten up by guards if they refused.
During the day, the women serving sentences in this prison undertake various activities, including training in courses such as dressmaking, breeding chickens and food cultivation. At night, they are prostitutes.
"Little doves", "bunnies" are some of the terms used by the prison guards to refer to the female prisoners during interaction with the clients. Guards charged CIP researchers MZN15,000 ($240) for two hours with an inmate.
Normally the prisoners are taken out on the days when the guard with whom the deal was negotiated is on duty at the prison. Generally, the inmates are taken out at the weekends and on public holidays. But in some cases, they are taken out in the middle of the week. The day is chosen largely in accordance with the availability of both the guard and of the client. The inmate is treated merely as merchandise. Even in the middle of the week, a way is arranged to take the inmates out
According to CIP, there are inmates who leave 3 or 4 times a week to have sexual relations with people they say they do not know.
Reports say that the sexual exploitation of inmates is a phenomenon that has been happening for many years in the Maputo Women's Special Prison and has remained hidden from the government authorities and from the organisations that defend human rights and the rights of prisoners.
The guards, taking advantage of the vulnerability of the prisoners and of the power they possess, push them into the world of prostitution in exchange for money. In addition, the inmates are sexually harassed and abused by the guards.
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Rockefeller Foundation's $3.8M grant helps position Ghana to accelerate future ICT job growth


Amazon's EC2 instances, by default, have both internal and external addressing (IP addresses and relevant hostnames), but only the internal addressing is readily available. What's more - Tigase uses the machine's addressing for various purposes: internal packet routing, inter-cluster communication and Tigase's Load Balancer (Tigase Load Balancing). In case of the latter - Tigase Load Balancer - this duality of addressing in AWS cloud would pose a problem because users would receive a redirection to an internal address to which they would not be able to connect.
These benefits are now deployed and available on Tigase hosted servers backed by Amazon Web Services. If you want to take advantage of these benefits for your own realtime communication solution, contact office@tigase.net to find out how.


Jessica Gorlee is an accomplished specialist in the field of vocal mechanics, speech and language.
Dutch born, Jessica received her Bachelor's degree in speech-language pathology at the Hogeschool van Utrecht (Faculty of Healthcare) in Utrecht, the Netherlands. She later emigrated to Sweden.
Jessica has helped hundreds of children, teenagers and adults in both The Netherlands and Sweden to communicate with ease and clarity in speech, language and with communication methods based in AAC (eg. pictures and communication devices).
In addition to her well informed knowledge of effective tools, Ms. Gorlee's inspiring, motivating, encouraging and positive approach to servicing her clients is another important asset. It opens ways to possibilities for her clients to reach improved abilities in communication. She does this with humour, enthusiasm, thoroughness and play, creating a conducive relaxed atmosphere making the learning process easy and fun.
In the Netherlands, Jessica worked with speech, language and voice disorders as well as oral motor/sensory control issues. Ms. Gorlee received coaching and professional experience in Inge Prevoo's practice for speech-language pathology and communication, as well as, at Jessica Donker's practice for speech-language pathology.
In Sweden, Ms. Gorlee received instruction and was for several years mentored by Speech-language pathologist and Sensory Integration-therapist Janneke Baas in treating children with different disabilities, like mental retardation, ADHD, autism and severe language impairments in a different way. Very often these children also have problems with their sensory processing. Read more abour sensory processing disorder here.
Ms Gorlee has worked at SLP-practice in Linköpings Academic Hospital, children's and youth rehabilitation centre, Logopedallians AB, the educational system in Ödeshög, Sweden and special education groups for children with severe language impairment in Linköpings Commune, Sweden.
At the same time, Jessica Gorlee has worked with children and adults under the auspices of her own private practice, The Voice and Communication Studio. She gives lectures and training for companies where staff are required to professionally utilize the voice in the work place, such as teachers, telephone solicitors and desk phone operators, fitness instructors, etc.
In addition to being an experienced speech-language pathologist, Ms. Gorlee is also a voice teacher and singing performing artist. In December 2012, Ms. Gorlee received authorization to teach the Complete Vocal Technique singing method following a 3-year study course at The Complete Vocal Institute in Copenhagen, Denmark.


Combines colorful spreads and easy-to-lift flaps in a celebration of the summer season that depicts babies splashing in a paddling pool, finding a pair of flip-flops and enjoying a cooling ice cream cone under a big yellow sun. By the creator of Baby Loves Spring! *Author: Katz, Karen *Series Title: Karen Katz Lift-the-Flap Books *Publication Date: 2012/05/01 *Binding Type: Hardcover *Grade Level: Preschool *Language: English *Depth: 0.
50 *Width: 6.50 *Height: 7.50.
At UnbeatableSale.com, we have the largest selection online and the best prices. Buying Baby Loves Summer! By Katz, Karen/ Katz, Karen (ILT) through an authorized dealer such as UnbeatableSale.com is the only way to ensure its quality and authenticity. Our everyday marked-down price is $9.12, $0.46 less than the retail price you'd pay at most stores. Can't decide? UnbeatableSale.com gift certificates are always just right! At UnbeatableSale.com we are committed to protecting the privacy of our customers and using personal information responsibly.


Sturgeon fishing has remained consistent, with an average of 4 – 7 fish a day. A lot of nice size fish being caught, the average has been around a hundred pounds. With fish in the seven to eight foot range being caught daily , which average anywhere from 200 to 300 lb plus. Last fish we caught the other day calculated out at 354 lbs. It was 97 in Long , with a girth of 47 in.
The fishing is about to pick up as we head into October. October, November is the last Feast before winter, winter is famine and the fish know it. November in particular has some fantastic fishing for both salmon and sturgeon. A lot of people Overlook November, but if you're looking for less crowds and killer fishing November is the time. The weather can be questionable, but our boat is fully enclosed, and we have a heater inside so everybody stays toasty.
We still have dates available in November, so drop us a line if you're looking to catch a beast.


text:
Sunday Talk Shows - 33m 9s ago
Campaign - 2h 16m ago
Opinion>Campaign
The Democratic nominee won't be democratically chosen
by Corey R. Lewandowski, opinion contributor - 02/22/20 11:00 AM ET
I was fortunate enough in 2016 to play a small role in the unprecedented political juggernaut that was the Trump campaign. Against a crowded field of senators, governors and names that Americans had known for decades, then-candidate Donald Trump emerged as a force outside the GOP establishment that none of the Washington types — the Republicans' political geniuses — could have ever seen coming.
Primary after primary, caucus after caucus, Trump just kept winning. Before the Republican National Convention in July, he exceed the number of delegates needed to clinch the party's nomination by more than 200.
Becoming the nominee was inevitable — even as some in the party didn't want to accept it.
Professional losers at the convention, more concerned with tone than taxpayers, worked the few remaining country club Republicans to try to force a floor fight. If you don't remember this, that's OK: It lasted all of an hour and went basically nowhere.
The Republican base voted for Donald Trump to be the nominee. The party understood this, and that was final. It is, after all, the will of the people that matters in a democracy, right?
Ask the Democrats.
It was a very simple question that NBC's "Meet the Press" host Chuck Todd posed to the candidates in Wednesday's debate in Las Vegas: Should the candidate with the most delegates at the end of the primary season be the nominee, even if they are short of a majority? Simple. Fair. Topical.
For the first time in many years, we are very likely heading toward a brokered convention for the Democrats. So in a world where there's no clear winner according to the rules of the game, would it be fair to award the nomination to the person who came closest to victory?
In essence, should the winner of the popular vote be the nominee?
Listen to what they said.
Former New York City Mayor Michael Bloomberg: "Whatever the rules of the Democratic Party are, they should be followed." Chuck Todd clarifies, "So you want the convention to work its will?" and Bloomberg replies, "Yes."
Sen. Elizabeth Warren (D-Mass.): "The convention working its will means people have the delegates that are pledged to them and they keep those delegates until you come to the convention, all of the people."
Former Vice President Joe Biden: "No, let the process work its way out."
Former South Bend, Ind., Mayor Pete Buttigieg: "Not necessarily, not till there's a majority."
Sen. Amy Klobuchar (D-Minn.): "Let the process work."
And finally, Sen. Bernie Sanders (I-Vt.): "Well, the process includes 500 superdelegates on the second ballot. So I think that the will of the people should prevail. Yes, the person who has the most votes should be the nominee."
This was actually astounding. Mayor Pete, whose platform includes a proposal to eliminate the Electoral College and replace it with a nationwide popular vote, stood onstage, stared down on the American people and argued that the Democratic nominee should not necessarily be chosen by a popular vote.
Warren, in her very lawyerly way of hiding behind allusions to intricacies of convention rules and delegate counts, avoided the simple form of her answer: No, the will of the Democratic voters is irrelevant unless it ends up in a delegate majority.
Bernie, whose 2016 campaign actually inspired the changes to the nominating process that have given the Democratic Party this new, perilous-looking system, was the only one to show any consistency between what's in his platform and what he believes.
And the thing about Bernie is, even if he weren't the new front-runner of the race, a fair characterization to make given his lead in delegate counts and enthusiasm to match, I believe he still would have answered the same way. And that's precisely why the Democratic National Committee (DNC) can't stand him.
Make no mistake — in a world where Sanders falls short of the majority of delegates, he will have the nomination stolen from him again. And each of the candidates who advocates for the dissolution of the Electoral College will just sit back and say, "Sorry, that's how the nominating process works."
Principle doesn't matter here. If it did, every party figure would have been outraged by the candidates' insistence that the will of the people expressed by a popular vote is meaningful only if it puts them over the delegate threshold.
This is about winning — about letting the DNC establishment choose its ideal candidate to face off against President Trump. It knows it's going to be a fight; it knows it's going to be tough to win. And for some reason, all these facts add up to the conclusion among party leaders — the Democrats' geniuses — that they can't afford to trust the will of their own voters.
Maybe they're right, for the sake of the general election, as far as they see it. Maybe not. But what I do know is that the desperate rallying cry among Democrats to "vote blue no matter who" implies that, at the end of the day, you are responsible to your voters.
If I were the DNC, I'd treat them with respect. Thinking they're incompetent usually isn't a good look.
But hey, trust the geniuses, right?
Corey R. Lewandowski is President Trump's former campaign manager and a senior adviser to the Trump-Pence 2020 campaign. He is a senior adviser to the Great America Committee, Vice President Mike Pence's political action committee. He is co-author with David Bossie of the new book, "Trump's Enemies," and of "Let Trump Be Trump: The Inside Story of His Rise to the Presidency." Follow him on Twitter @CLewandowski_.
Tags Amy Klobuchar Bernie Sanders Brokered convention Chuck Todd Democratic National Committee Democratic Party Donald Trump Elizabeth Warren Joe Biden Michael Bloomberg Mike Pence Pete Buttigieg superdelegates
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text:
Q: Fluent nHibernate required files and linux I've downloaded the fluent hibernate 1.2 zip file from the website.
It contains various files, amongst them
NHibernate.dll
FluentNHibernate.dll
Castle.Core.dll
Remotion.Data.Linq.dll
Antlr3.Runtime.dll
Iesi.Collections.dll
NHibernate.ByteCode.Castle.dll
Q1) Are all these files required for doing a simple application?. By simple I mean that the db contains a few tables that doesn't need complicated queries and has limited levels/amounts of reference keys and joins.
Q2) Does fluent nHibernate run on mono on linux?

A: *

*no; see here for what's needed and what's optional.

*it runs wherever you can run (and develop) .net programs (i.e it, obviouslly, needs .net runtime environment).

redpajama_set_name: RedPajamaStackExchange


After two decades as an action film icon, Chuck Norris took his talents to television with Walker, Texas Ranger in 1993. The contemporary Western series scored high ratings for eight years — and continues to be a fan favorite a quarter of a century later.
But Norris never lost his taste for longer-form storytelling. Over nine seasons, the adventures of Sergeant Cordell Walker often expanded beyond the bounds of hour-long episodes. We like to think of those two-parters as Chuck Norris action movies that just happened to air on TV. And you can see what we mean when getTV presents special two-part episodes of Walker, Texas Ranger every Saturday night in April starting at 8p ET!
Like most of Norris' characters, Cordell Walker is an ethical peacemaker who uses force only when necessary. But when it's necessary, look out. He's assisted by former football star Jimmy Trivette (Clarence Gilyard) and C.D. Parker (Noble Willingham), a retired ranger who owns the local watering hole. Assistant D.A. Alex Cahill (Sheree J. Wilson) sometimes disagrees with Walker's methods, but eventually succumbs to his charms (and SPOILER ALERT) marries him in the final season!
Walker, Texas Ranger was co-created by two Oscar winners — Albert S. Ruddy (producer of The Godfather and Million Dollar Baby) and Paul Haggis (writer/director of Crash) — and its cinematic pedigree is particularly on display in these two-part episodes. The increased running times allow for additional backstory and character development. And two of the four airing this month are directed by Michael Preece, who helmed more Walker episodes than any other director. Each one is a great introduction to the series and a perfect excuse to introduce new viewers to Cordell Walker and friends!
The Walker saga begins with the two-part pilot, originally aired on April 21, 1993. Alex, C.D. (played by Gailard Sartain in this episode only), and Walker's boss Captain Tom Price (The Virginian star James Drury) are introduced. And we meet the brash Trivette, a Texas Ranger thanks to C.D.'s good influence. We also learn Walker's backstory: his Cherokee father and white mother were murdered in a racially motivated attack, and Cordell was raised by his uncle Ray (Floyd "Red Crow" Westerman). Walker and Trivette's first mission as partners is to bust a ring of weapons-crazy bank robbers and avenge the death of a young ranger (Steven Ruge). Most shows need a few episodes to refine style and tone. Walker, Texas Ranger had it down from the get-go.
Originally aired in January of 1994, this episode finds Walker and Trivette on the trail of a vicious drug ring and a predator at the local university. It also touches on a few of Norris' favorite topics: the dangers of drugs, the healing powers of martial arts, and the importance of positive influence on kids. Look for 19-year-old Giovanni Ribisi (Avatar) as a teenager forced to be a drug runner by his mom's boyfriend (Jeff Kober) and soap star Ellen Dolan (Guiding Light, As The World Turns) as his abused mother. Also look for some early Walker/Alex "shipping" drama, as they both get romantic with other people!
Walker is injured and ordered to take time off, so he plans a fishing trip with Jimmy and C.D. to Black Bayou Lake in Louisiana. There they stumble upon meth manufacturer Ferris Clayton (David Huddleston) and his dim-witted sons (including Chuck's son Mike Norris). Walker's head injury triggers flashbacks, and an opportunity for some backstory. "Cordell wasn't a regular soldier in Vietnam," C.D. tells Jimmy. "He was a one-man recon team. They used to send him out for weeks at a time in the jungle and it really developed that dark side of him." This episode is clearly a throwback to Norris's hugely popular Missing In Action series of films.
When Walker's ex-partner Logan Reno (Buck Taylor) is killed in a bank heist, he and Trivette go after a crew of clown-masked killers. Meanwhile, Walker tries to help Logan's rebellious teen son (Ian Bohen) stay out of trouble with the law. Look for Wilford Brimley (Our House, Cocoon) as the owner of an armored car company and Tim Thomerson (Trancers) as the head thief. This well-plotted episode is a twisty treat and a must for any fans of "heist" films. Plus, Norris has a fight with 400-pound, six-foot-four-inch wrestler Jeep Swenson that proves something everyone should know: nobody can beat Chuck Norris!
Special, two-part Walker, Texas Ranger episodes air Saturday nights at 8p ET in April on getTV. And look for the series at its new weekday start time — 12p ET. For more, visit the getTV schedule.


Not necessarily for time, but your ultimate goal should be to get all the way through each exercise without a break. Rest between exercises as needed.
We are going back at the legs again after a rough week last week. We need it. It'll help tune them up.
Do the non-cardio stuff in any order, but you must bookend the cardios. May have to flip flop based on machine availability.
Workout is not for time. That being said, try to complete each exercise without breaks (rookies ignore).
Rest between exercises as needed.
Worth a read. I've been following Marc's progress intently for most of this year. He is an inspiration to me. This kind of thing (below) shows why.
Ashley and Jess demo how to make it fun! That kid as a $1m smile!