text:
Q: Java: RMI issue Hi im trying to connect a client-server application in Java with RMI, in the client i have this
public static void main (String[] args)
{
    try
    {
        Registry registro = LocateRegistry.getRegistry("192.168.1.19",1099);
        System.out.println("Cliente esta Corriendo");

    }
    catch (Exception e)
    {
        System.out.println(e);
    }
    ClienteERI consumir = new ClienteERI();
    consumir.sumaRemota(2, 3);
}

and in the server i have this
public static void main(String[] args) {
      try {
        Registry registro = LocateRegistry.createRegistry(1091);
        registro.rebind("servidor", new ServidorERI());
        System.out.println("Servidor esta corriendo");
    } catch (Exception e){
        System.out.println(e);
    }
}

but in the client i have this exception
java.rmi.ConnectException: Connection refused to host: 127.0.1.1; nested exception is:
    java.net.ConnectException: Connection refused: connect
and in the client  i have the server address correctly (i have check the server addres for a houndred times)
please som

A: You were correct in trying to check the address a hundred times. The error IS there.
client:

LocateRegistry.getRegistry("192.168.1.19",1099);

server:

LocateRegistry.createRegistry(1091);

These ports need to match.


One of the benefits of being an AdWords Top Contributor is that we get invited to big events like I/O without having to enter the lottery. Unfortunately, I couldn't make it this year due to a combination of workload and injury. Fortunately, there have been many neat advances in live streaming technology in the past few years with Google at the forefront of that technology. You can now watch the live stream of the Google I/O keynote and subsequent events below. I've also included a schedule and timetable for those who don't have a whole two days to watch every minute. What do you hope is revealed this year? For me, I'm hoping that we get some extended Android widget functionality and some greater API access. Keynote starts at 5pm GMT.
What do you think of the announcements?
Who cares about new domain names? We do. If you want happy users, then you should too.
A 3D tablet, an OSCAR, and a little cash. Tango, Spotlight, Ara. ATAP.
Don't Listen to Users, Sample Their Experience!
The dawn of "Fast Data"


text:
Koltan Greenwood - January 21, 2020
Mackenzie Templeton - January 21, 2020
Joe Smith-Engelhardt - January 20, 2020
Funko is unleashing an onslaught of new Pop! vinyl figures including ones for bands like Slipknot, Weezer, Ghost and more, plus movies like The Craft and Creepshow. The company just launched...
Former Black Veil Brides bassist Ashley Purdy reveals in a new interview that he didn't choose to depart from the band back in November. In an...
Nickelback are teasing something big relating to their massively successful All The Right Reasons album which turns 15 this year. The band posted a clip featuring...
Max Bemis reveals Say Anything song he thought would be more popular
News Rachel Campbell - January 20, 2020
It's been nearly a year since Say Anything released their final album, Oliver Appropriate, which also marked the sequel to 2004's ...Is A Real Boy. With no...
Hayley Williams reveals Petals For Armor song title with latest teaser
We're two days away from Paramore frontwoman Hayley Williams unleashing her new project presumably titled Petals For Armor. With weeks of teasers, the vocalist has finally added...
Slipknot fans divided on Glasgow show's spiked accessories "safety" ban
News Alyssa Quiles - January 20, 2020
Fans were banned from wearing an assortment of accessories including spiked collars and large belt buckles at Slipknot concert at the SSE Hydro in Glasglow this past...
Features Alex Darus - January 20, 2020
It's safe to say that 2019 was the year of My Chemical Romance. The band performed their long-awaited return after a six-year hiatus with hopes of a...
Post Malone stars in new Netflix action-comedy 'Spenser Confidential'
As if Post Malone isn't impressive enough with his musical skills, you'll soon be able to catch the singer on the screen starring with Mark Wahlberg in...
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Scott Waldman - January 16, 2020
Bones UK are ready to break down the Grammys' doors
Jason Pettigrew - January 14, 2020
10 bands who should open for a dream My Chemical Romance...
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Trophy Eyes team up with WWE's Seth Rollins for "Figure Eight" video
Australian punk rockers Trophy Eyes and WWE's prodigal son Seth Rollins combine for what might be the oddest Tag Team in history. Well, at...
Sum 41 Paris gig canceled after firecracker set off nearby, venue says
Alyssa Quiles - January 20, 2020
On Saturday, Sum 41 cancelled a show in Paris after an explosive device went off outside of the performance space, but the venue manager...
All Time Low fans speculate new song release with latest cryptic logo tease
All Time Low are continuing their cryptic announcements. Today, the Baltimore-based punks dropped their fourth. This time, however, we have something tangible. The band...
Which song would be on your Myspace player in the Rawring '20s?
It's finally 2020, a new decade that many former Myspace users are dubbing the "Rawring '20s." Needless to say, we're in full support of making...
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redpajama_set_name: RedPajamaCommonCrawl


text:
.. meta::
    :author: Cask Data, Inc.
    :copyright: Copyright © 2014 Cask Data, Inc.

=================
CDAP Abstractions
=================

CDAP abstractions provide portability by decoupling your data and applications from the underlying infrastructure.
CDAP lets you abstract your data and applications by injecting abstraction layers over various components
of the Hadoop ecosystem. To access and manipulate data, you use CDAP's datasets rather than actual
storage engines such as HDFS or HBase. Similarly, you write your applications using CDAP's developer interface
and run them inside application containers. These containers are a logical abstraction that can be realized
differently in several runtime environments, such as in-memory, standalone, or distributed cluster.
You can deploy and run in different environments without the need to change a single line of application
code.

.. image:: ../_images/arch_logical_view.png
   :width: 5in
   :align: center

In this diagram, CDAP System components are in orange and non-system components are in yellow, with Hadoop
infrastructure in grey.

Data Abstraction
----------------

In CDAP applications, you interact with data through *datasets*. Datasets provide abstraction through:

- Abstraction of the actual representation of data in storage. You can write your code or queries without
  having to know where and how your data is stored—be it in HBase, LevelDB or a relational database.
- Encapsulation of data access patterns and business logic as reusable, managed Java code.
- Consistency of your data under highly concurrent access using the
  `Apache Tephra™ transaction system <http://tephra.incubator.apache.org>`__.
- Injection of datasets into different programming paradigms and runtimes. As soon as your data is in a
  dataset, you can immediately use it: in real-time programs; in batch processing applications such as MapReduce
  and Spark; in ad-hoc SQL queries.

Application Abstraction
-----------------------

CDAP's programming interfaces have multiple implementations in different runtime environments. You build
your applications against the CDAP Developer API. The API hides the low-level details of individual
programming paradigms and execution environments. It enriches the infrastructure with numerous useful
services that are typically needed by Big Data applications, such as service discovery, log and metrics
collection, and configuration. The environment-specific implementations of these services are injected
by CDAP into the program containers in which the application is run—the application itself does not
need to change based on the environment. This allows you to develop applications in one environment—on
your laptop using a Standalone CDAP for testing—and then seamlessly deploy them in the different
environment of a distributed staging cluster.

Deployment of an application as well as its lifecycle management, monitoring and scaling are done
through CDAP's Client API. Similarly to the Developer API, it is the same in every environment. The
experience of managing your application does not change when moving from one environment to another.

Developer Focus
---------------

CDAP supports developers through the entire application development lifecycle:
development, debugging, testing, continuous integration and production. Using familiar
development tools such as *IntelliJ* and *Eclipse*, you can build, test and debug your
application right on your laptop with a *Standalone CDAP*. Utilize the application unit
test framework (which embeds an *In-Memory CDAP*) for continuous integration. Deploy
to a development cloud or production cloud (*Distributed CDAP*) with a push of a button.
No matter which environment you are in, the experience of managing the application remains
largely the same.

redpajama_set_name: RedPajamaGithub


And that is what we are experiencing today. Children are the canaries in the coal mine.
When they manifest increased rates of adult diseases like hypertension or high triglycerides, something's wrong. And when they get diseases that have never previously been seen in children, like type 2 diabetes and fatty liver disease, it's time to re-evaluate.
Where could these diseases come from?
Certain countries are obese without being diabetic (e.g. Iceland, Mongolia, Micronesia), while other countries are diabetic without being obese (e.g. India, Pakistan, China). China has 12% diabetes, and they're not fat; the USA is the fattest nation on earth, and the diabetes prevalence is only 9%.
While 80% of the obese population is metabolically ill, that means 20% are not. Conversely, 40% of the normal weight population harbours these same diseases. If normal weight people get them, how is this related to obesity? Indeed, we now know that obesity is a marker rather than a cause for these diseases, termed "metabolic syndrome".
So what causes metabolic syndrome?
Everyone assumes it's the burden of our consumed calories in total; no one specific food causes it, because "a calorie is a calorie".
Yet a group at UCSF has provided the proof that relegates this thesis to the dustbin of history.
They studied 43 Latino and African-American children with obesity and metabolic syndrome over a 10-day period. They assessed their metabolic status on their home diet. And then, for the next nine days, the researchers catered their meals – NO ADDED SUGAR. We gave them the same calories and protein and fat content as their home diet.
We gave them the same percentage of carbohydrate; however, we substituted starch for sugar. We took the chicken teriyaki out. We put the turkey hot dogs in. We took the sweetened yogurt out.
We put the baked potato chips in. We took the donuts out. We put the bagels in. We gave them unhealthy processed food, but it was NO ADDED SUGAR food. We gave them a scale to take home. If their weight was declining, we made them eat more. Then we studied them again.
In short, every aspect of their metabolic health improved, with no change in weight. Blood pressure, triglycerides, low density lipoprotein (LDL), insulin sensitivity and glucose tolerance all improved, and on the same number of calories and without weight loss, just by removing the added sugar – and in just 10 days! Furthermore, their cardiovascular risk factors disappeared into thin air.
This study demonstrates categorically that, "a calorie is not a calorie", and that sugar is causative for metabolic syndrome, unrelated to calories or weight gain. Sugar may not be the only cause, but it is by far and away the easiest cause to avoid.
Kids could improve their metabolic health – even while continuing to eat processed food – just by dumping the sugar. Can you imagine how much healthier they'd be if they ate real food?
The naysayers will say, "But sugar is natural. Sugar's been with us for thousands of years. Sugar is FOOD! How can food be toxic?" This begs the question: What is food?
Is sugar food? Webster's Dictionary defines food as "material consisting essentially of protein, carbohydrate, and fat used in the body of an organism to sustain growth, repair and vital processes, and to furnish energy". Sugar furnishes energy, so of course it's a food!
But wait… can you name an energy source that is not nutritious, where there is no biochemical reaction in the human body (or in any organism) that requires it, that causes disease when consumed at high dose, yet we love it anyway and it's addictive?
Answer: alcohol. It's got calories, but it's not nutritious. There's no biochemical reaction that requires it, and at high doses, alcohol can fry your liver.
Yet we love it anyway. Alcohol is not dangerous because of its calories. Alcohol is not dangerous because it makes you put on weight. Alcohol is dangerous because it's alcohol.
Clearly, alcohol is NOT a food. It's not nutritious. When consumed in excess, it's a toxin.
Same with sugar. Fructose, the sweet molecule in sugar, contains calories that you can burn for energy, but it's not nutritious, because there's no biochemical reaction that requires it. And when consumed in excess, sugar fries your liver. Just like alcohol.
And this makes sense, because where do you get alcohol from? Fermentation of sugar. Sugar causes diabetes, heart disease, fatty liver disease and tooth decay. Sugar's not dangerous because of its calories, or because it makes you fat. Sugar is dangerous because it's sugar.
It's not nutritious. When consumed in excess, it's a toxin.
And it's addictive. Fructose directly increases consumption independent of energy need. Sucrose infusion directly into the nucleus accumbens reduces dopamine and μ-opioid receptors similar to morphine, and establishes hard-wired pathways for craving in these areas that can be identiied by fMRI. Indeed, sweetness surpasses cocaine as reward.
Animal models of intermittent sugar administration induces behavioural alterations consistent with dependence, i.e. bingeing, withdrawal, craving and cross-sensitisation to other drugs of abuse.
Sugar is just like alcohol. And that's why children are getting the diseases of alcohol – type 2 diabetes and fatty liver disease – without alcohol. But we could turn this around in 10 days – if we choose to.
Written by Prof. Robert Lustig is Professor of Paediatrics and founder of the Weight Assessment for Teen and Child Health (WATCH) Program at UCSF Benioff Children's Hospital, and member of the Institute for Health Policy Studies at UCSF.
He is the author of Fat Chance, the upcoming The Agony of Ecstasy, and he is the President of the non-proit Institute for Responsible Nutrition.


Adjacent to San Francisco's Union Square, Hotel G is the latest reincarnation of a storied 1908 building that was previously Hotel Frank and before that the Fielding Hotel.
A two-year restoration under the watchful eye of New York outfit Hun Aw Studio, saw extraneous layers of plaster and paint peeled away to result in an cool 153-room property layered with fog-coloured walls, wood finishes and earthy textiles that are revealed through Victorian settees, bankers' lamps and mid-century writing desks.
Now, four years after it opened, the property has launched its Penthouse Level with two Terrace Suites and a Grande Penthouse. This time designed by LA-based Gulla Jónsdóttir, the new additions slot nicely into the existing blueprint, giving way to a slicker, more sultry vibe. As such, raw materials including Dalmata marble, concrete-like walls, brass and whitewashed oak flooring are softened with plush curved furnishings, mural motif art walls, and Kashmir leather beds. Each suite also comes with its own deck, dressed in Okoume furniture, which is arranged around a fire pit, making it the perfect spot to enjoy a glass of champagne, while watching the sun go down.


text:
Home›Email›Scientists convinced European heat waves boosted by climate change
EmailEuropeHightlightsReadScience & EnvironmentTravelWorld News
Scientists convinced European heat waves boosted by climate change
As Germany and Spain sweated and London sweltered through its hottest July day on record this week, scientists said it is "virtually certain" that climate change is increasing the likelihood of such heat waves in Europe.
In real-time data analysis released on Friday, a team of international climate scientists from universities, meteorological services and research organizations said the kind of heat waves hitting Europe this week – defined as three-day periods of excessive heat – are becoming much more frequent in the region.
In De Bilt in the Netherlands, for example, a heat wave like the one forecast for the next few days would have been a roughly 1-in-30-years event in the 1900s, according to the scientists. It is now likely to happen every three and a half years, they said.
In Mannheim, Germany, a heat wave like that of the last few days would have been a once-in-a-century event in the 1900s, but is now likely to happen about every 15 years, they said.
London also saw its hottest recorded July day on Wednesday, with temperatures at Heathrow Airport hitting 36.7 Celsius, the scientists noted.
As heat waves grow more frequent, "it does resonate with a much wider audience that this is connected to climate change and we're facing a new normal", said Maarten van Aalst, director of the Red Cross Red Crescent Climate Centre.
The heat wave analysis, which looked at five European cities, is part of a World Weather Attribution program led by Climate Central, a U.S.-based science journalism organization, and supported by scientists from organizations around the world, including Oxford University, the University of Melbourne, the Royal Netherlands Meteorological Institute and van Aalst's Climate Centre.
The program aims to use climate and weather data, forecasting and climate models to show how changing weather patterns are linked to climate change.
It hopes to help cities and countries better understand and prepare for more extreme weather like this week's scorching days in Europe.
The Netherlands Central Bureau of Statistics has predicted that on average 200 more people will die in that country each week during a heat wave, a 10 percent rise in deaths.
Deaths among the isolated elderly are a particular problem, and accounted for a big share of the estimated 70,000 additional people who died in France and other European nations during a 2003 heat wave.
At that time, "people were really caught unawares by the combination of rising risk and changing structure of society", van Aalst said.
Traditionally, extended families have looked after the elderly in places like France, he said. But social changes now mean many more older people live alone in cities, with no one to ensure they do basic things like drink enough water in the heat.
Cities facing heat waves are having to adjust the way they deal with the threat, including through simple measures such as sending out social media messages urging people to "give a call to your grandmother", van Aalst said.
In the Netherlands, television weather presenters now remind viewers when the country's "heat wave plan" – put together after a 2006 heat wave there – has been activated, and give them tips on how to stay cool, he said.
Across Europe, "there's been a massive investment in such plans", he said, alongside a range of efforts to deal with more frequent heat waves, such as adding green spaces in cities.
UN declares highest-level aid emergency in Yemen
Bombings kill 19 people in and around Baghdad
Italy's coronavirus death toll rises by 525, new cases push higher
Fears of fresh food shortages mount as UK faces isolation
Robot helps Tunisia medics avoid infection from virus patients


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text:
Play N Skillz ft. Akon - Angel Eyez
Burmy
Artist: Play N Skillz
Track: Angel Eyez ft. Akon
Feat. Akon
Producer: Play N Skillz
Album: Out Tha Box
Though DJBooth is now in its fourth year of featuring new music, several artists who were working on new albums when we began are still preparing the same projects for release. Such is the case for superproducers Play N Skillz, whose long-delayed sophomore album, Out Tha Box is currently due to be released this spring. Now, the duo has released a new single that they hope will lead to a solid release date. Together with international sensation Akon, the Texas natives are – stop me if you've heard this before – completely head-over-heels over a woman they see. Unlike most rap ballads, however, this record finds the artists most fascinated by the shorty's Angel Eyez. For further information on Out Tha Box's release, keep your eyes glued to DJBooth.net.
Play N SkillzAkon
Play N Skillz Battle Akon on the Hardwood [Video]
Play-N-Skillz ft. Jay Z - Checkin' My Fresh


For details on our latest corporate profile, please see TAISEI's official website.
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4thFloor, Building No. 37, Foreign Culture Creativity Park, 19 Chegongzhuang Xi Road, Haidian District, BEIJING, P.R.C.
Copyright TAISEI CORPORATION All Rights Reserved.


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text:
THE MUSICIAN MOVIE
schimmelmark@comcast.net
About The Musician
ALL ABOUT THE MUSICIAN MOVIE
A famous violinist spends her days dressing up as a busker (street musician)
and believes that sharing her music can transform lives.Note: "The Musician" was filmed
as a silent movie, sound effects, music and some dialogue were placed in the film
during postproduction. One Chicago morning, while playing on the Clark Street Bridge, the musician is approached by an intimidating security officer. Distracted during the confrontation,
her prized violin is stolen by a small street child.
Defeated by not being able to catch the child, the musician gives up all hope to recover her violin. She fantasizes about having her instrument back in her hands. At that moment she hears the plucking of strings in the distance. The musician follows the sounds to see the street child attempting to play. As the musician approaches, the child threatens to break the violin. Just then, the musician has an idea. She begins to airplay a violin using only her bow. Mesmerized, the child begins to imitate her every move. Soon the two are communicating through the passion of music.The child decides to give the violin back to the musician. The two continue to play and dance in the park using the sounds of music to lead them.When it's time to part ways, the musician leaves, making her way to a performance. The child follows her and sneaks into the backstage area of the theatre to watch the musician on stage. At this moment the bond is complete and the musician has inspired another person through the magic of her music. At the end of the story, the child is transformed and left with the violin to
pursue her own dreams of becoming a musician.
This film stars and features the music of Anne Harris. The movie was shot within three days with on-location sound recording. All of the sounds were manufactured during the post-production process. Playing the child, this is Reese Harley's first on-camera performance.
©2021 by The Musician Movie. Proudly created with Wix.com


Submitted by theresa on Fri, 07/27/2018 - 5:12pm.
Initiation is one of the essential keys to fulfilling life purpose, manifesting your greater potential, and harnessing your innate gifts. With the tools handed down through this ancient lineage, the path to transforming your life while enriching the lives of others is available to the sincere seeker.
The teachings given for this initiation create a pattern of living that will empower you to master your life and create change in the world. Through this process you will learn how to quiet your mind and tune in to your heart more.
The focus is on knowing yourself in relationship to the world around you. Entering the Mysteries is a deeply rewarding path that will ultimately increase the quality of your life and empower you to be consciously at cause in this world. In order to reach your highest potential and to reach goals you have never reached before, you must do things you have never done before!
If you feel that even one of the above statements describes you, contact us to connect you with a Certified Modern Mystery School Guide to learn more about initiation and if it is right for you.
"This initiation changed my life. It touched my heart while quenching my thirst for answers, whereas other spiritual traditions had left me still searching. I could not have imagined what was in store for me as I prepared for the weekend and I am excited and hopeful for anyone who considers taking this step." -- Marcy J.
"Thank you again for a very special weekend. Everyone was "blown away" by the presentation for the initiation! The education portion of the class was amazing! And, the initiation was unforgettable! I feel like a different person. I am so honored to be a part of the Brotherhood & Sisterhood of Light." -- Wanda O.
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A $300 non-refundable deposit is required to RSVP.
If you strongly feel called to take this step of empowerment and money is a concern, then please call to discuss payment plan options.


A pretty neckline ruffle adds a retro-feminine touch to Belabumbum's super soft maternity and nursing chemise. A comfortable choice for mom to wear during those long nursing marathons. Top this flattering chemise off with our coordinating Paisley Dreams robe.


I was wondering why yetunde that has been so unfriendly to me just suddenly turned nice. Well, maybe its her nature to appear harsh before showing her nice part to a stranger. I said to myself.
YETUNDE: And if I eat the food your wife prepared for you, what are you going to eat.
ME: and what's surprising about that?
YETUNDE: Never mind…..We continue discussing till we got to my Hostel. We entered together into my room. There was PHCN light so I switched on the socket and the sound system to play some music's. I inserted a disc containing my full tracks and we were listening to it.
Yetunde: "Smiling face" Who is that person singing?
Me: Whose voice does it resemble?
Yetunde: I don't know, I'm only asking because I love the songs.
Me: "laughs" and you love the person too?
Yetunde:" Love kor", person that I don't know.
Me: it's someone you know.
Yetunde: it's a lie. You ke, you can't even sing at all.
Yetunde: How am I going to be sure?
Me: Does it mean you don't believe me?
YETUNDE: I'm finding it so difficult to believe you I dashed to the anger and removed one of my customized shirts. And I started a track again from intro so that she could hear the name, before she believe I was the one singing.
Yetunde: So you are a musician.
YETUNDE: Yes. You will sing for me before I go.
Me: yes but finish your food first.
ME: what have I done this time?
Me: (pretended as if I didn't know what she meant) what? Where?
Yetunde: You fu©k€d her real good.
Yetunde: (bursted into laughter) sorry for what?


text:
What are the Sainsbury's School Games?
The Sainsbury's School Games are a unique opportunity to motivate and inspire millions of young people across the country to take part in more competitive school sport.
The Games are made up of three levels of activity: competition in schools, between schools, at county/area level and a national event for the most talented young people in the UK:
• Intra-school (Level 1) - sporting competition for all students in school through intra-school competition
• Inter-school (Level 2) - individuals and teams are selected to represent their schools in local inter-school competitions
• Sainsbury's School Games Festivals (Level 3) – the county/area will stage multi-sport Sainsbury's School Games Festivals as a culmination of year-round school sport competition.
Spirit of the Games - Values
The Sainsbury's School Games is based around 6 key values. We encourage our children to follow these values, not only in sport, but in everything they do. Children who demonstrate these values will be celebrated in school assemblies.
The Spirit of the Games Values focus on personal excellence through competition. There are six values:
Treat everyone equally, support each other's and work together to have fun and achieve. Celebrate each others' success. Be a good friend and a positive team player in school, sport and life.
Treating others politelyand with understanding. Accepting life's 'ups and downs' with grace. Respect everyday, in everything you do and for everyone around you.
You've got to believe to achieve. Have the self belief and confidence to succeed and reach your personal best.
Keep going no matter what. Determination is about the journey you go on to push yourself and achieve your dreams. Have the mental strength and the self discipline to overcome obstacles, commit to your goals and keep working every day to become the very best you can be. Don't hold back!


text:
Q: AdMob: filter ads for kids I managed to run AdMob sdk on my Android & iOS application and it's displaying ads perfectly.
I am trying to filter the ads to only include ads that a child would click.
In AdMob you will have a list of ads categories allowed by default and you only can ban fifty of them. I don't think that this is the approach anyway.
Anyone had this experience before? Do you suggest to change ads provider anything else than AdMob? Please, consider mentioning clear and valuable explanations.

A: Admob do not provide such an approach.
Admob only allow blocking a limited number of categories and subcategories. and leaves the others active. (This is kind of their strategy for advertising).
Nevertheless, you can add other ads networks to your AdMob as mediation networks. (admob will also provide you with ads from these networks).
List of popular ads networks
List of Ads networks that provide some kind of filters:

*

*Adfonic: a middle east advertising network. allows inserting keywords for your app as categories and they will try to provide you with ads in the same category. They are still beginners. maybe they are good for the middle east, not more.

*Chartboost: if you have a game app. yeehaa, you are saved. Chartboost provide game ads only for game apps. but, unfortunately you can't integrate chartboost with admob. it works alone.

3. MobFox: allow category blocks as much as you want. Ex. you can keep games and educational ads. Also, it could be integrated with AdMob.

Admob Mediation Networks Integration

A: If you develop apps specifically for children, I would suggest using COPPA Compliant SDK, such as KIDOZ - http://kidoz.net. They have all kinds of solutions for developers in the kids' segment.

redpajama_set_name: RedPajamaStackExchange


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Gene Hackers: The Young Biotech Entrepreneurs Looking To Make Billions By Editing Life Itself
hen Rachel Haurwitz started her biology Ph.D. at the University of California, Berkeley, the award-winning biochemist Jennifer Doudna suggested Haurwitz investigate part of a bacterial immune system. She studied how microbes store genetic mementos of attacking viruses and recognize them to fight off future assaults. "It was an esoteric project," Haurwitz says.
It's esoteric no more. This system, called Crispr, has become one of the hottest technologies in biology, with the potential to give scientists control of the building blocks of life and give investors rich rewards. Crispr had no obvious relevance to human health when it was first described in 1987, but Doudna, who won the Breakthrough Prize in Life Sciences for her Crispr work, and other pioneers have discovered ways to turn it into a gene-editing tool. Haurwitz and Doudna helped found Caribou Biosciences in 2011 to get in on the action. Haurwitz, still in her 20s, became CEO the next year.
Haurwitz is not the only young entrepreneur who sees opportunity in gene editing. Doudna cofounded Mammoth Biosciences with some of her other doctoral students and two Stanford Ph.D.s. Trevor Martin, the company's 30-year-old CEO, has raised $23 million from such investors as Apple CEO Tim Cook. In 2015, in Cambridge, Massachusetts, 29-year-old Luhan Yang founded eGenesis with her mentor, Harvard geneticist George Church, to use Crispr to help transplant pig organs into people. Omar Abudayyeh and Jonathan Gootenberg, also in their 20s, cofounded Sherlock Biosciences with another Crispr pioneer, 37-year-old Feng Zhang of the Broad Institute of MIT and Harvard.
"They may be young, but in both cases these are people at the top of their game scientifically," Doudna says of her cofounders. "They're fearless in all the right ways and very aware of the ethical challenges."
Given that no one had built a Crispr company until a few years ago, "there's maybe more of an opportunity for people with nontraditional backgrounds," Haurwitz says.
Crispr is an acronym for "clustered regularly interspaced short palindromic repeats." It refers to the way bacteria store, in their genomes, snippets of viral DNA, like mug shots. Those markers are used to identify invaders that return, much as a human immune system uses telltale elements of a polio virus remembered from a vaccine.
If an invading virus matches a stored mug shot, enzymes associated with Crispr break the virus' lethal DNA into harmless pieces. Doudna and others figured out how to use those enzymes to snip DNA at precise points in order to insert or modify genes. Thus does Crispr promise to make the expensive and buggy process of rewriting DNA easier, opening up new ways to treat diseases caused by genetic mutations, create cheaper diagnostic tests and engineer cells that kill cancer.
Eight years after its start in Berkeley, Caribou has raised $41 million and cut licensing deals—potentially worth hundreds of millions of dollars—with DuPont Pioneer, Novartis and others. It's starting to develop medical therapies.
Haurwitz grew up in Austin, Texas, and earned a bachelor's degree in biology at Harvard. She didn't have a clear plan when she went on to UC Berkeley, but she thought she might later become a patent attorney.
That thinking changed as her Ph.D. work got more exciting. Haurwitz and Doudna spent a lot of time talking about how they could repurpose Crispr for modifying genomes to cure disease. Program the naturally occurring Crispr system to cut the gene you want to modify, and it's theoretically possible to use it to change the genetic code to either fix "misspellings" that cause illness or disrupt the production of an unwanted protein.
Caribou started out with the notion of making Crispr technology available for DNA editing in applications such as drug development, agriculture and basic biological research. Haurwitz's cofounders didn't want to leave academia and were "crazy enough to let a 26-year-old who had never worked for a company in her life take on the role of president and CEO," she says.
Haurwitz took a few business classes before getting her Ph.D., then pitched venture capitalists on funding a technology they didn't really understand. Caribou was securing an exclusive license to some Crispr patents held by the University of California system and the University of Vienna. Still, "pretty much every VC we talked to kind of said, 'Meh,' " Haurwitz remembers. This was 2012, and they thought she was overestimating Crispr's potential.
The papers that propelled Crispr into the limelight came the next year, and investor dollars and a wave of new companies quickly followed. Editas Medicine, cofounded by Sherlock's Feng Zhang, raised $43 million to apply the technology to medical therapies. Next was Intellia Therapeutics, cofounded by Caribou, which raised $15 million in its 2014 launch. And Crispr Therapeutics, founded by Crispr pioneer Emmanuelle Charpentier, raised $89 million. The three went public in 2016 and now have a combined market capitalization of $3.8 billion.
Meanwhile, Haurwitz was being cold-called by plant-breeding and drug companies. DuPont led an $11 million investment in 2015. Caribou raised another $30 million the next year and has been able to sustain itself on that funding and payments from licensing and partnership deals.
Caribou licensed to Integrated DNA Technologies the right to sell biology researchers what they'd need for gene-editing experiments. Genus, an animal genetics firm, paid Caribou an undisclosed amount for the exclusive right to use its proprietary Crispr technology to engineer the genes of pigs and other livestock. Similarly, the Jackson Laboratory is paying Caribou to use Crispr to engineer new populations of research mice that model human diseases.
Haurwitz will soon have to seek venture capital again, as Caribou has pivoted to drug development, which is expensive but potentially more lucrative. Her first focus: improve on existing cancer therapies that take patients' immune cells and train them to attack cancer. Crispr, she says, could be used to edit the DNA of immune cells from healthy donors so that these cells could be given to any cancer patient. The company plans to start trials in humans next year. There's competition, from Allogene Therapeutics and its partner Cellectis, which have a combined market cap of $3.9 billion.
Caribou is also developing a program in another buzzy area: the microbiome, or the many bacteria that inhabit all parts of the human body, particularly the gut. This time, investors know what Crispr is, and Haurwitz has already won some over. "She's one of the few people that I've met in my life that is able to toggle between business talk and scientific talk in a heartbeat," says Ambar Bhattacharyya, a Caribou investor at Maverick Ventures.
Beyond the competition, there is an intellectual property conflict. Overlapping patent claims from the University of California and the Broad Institute emerged for the foundational technology, which involves an enzyme called Cas9, used to cut DNA. A lawsuit between the institutions was decided in favor of the Broad, but the U.S. Patent Office has granted patents to both. UC's patents claim broader rights than were demonstrated in its application, says Lisa Ouellette, a Stanford Law School professor, and could make them vulnerable to a legal challenge. (UC disagrees.)
Whoever owns the technology will command fat fees. Caribou might run trials related to a particular gene, but if other companies want to run trials related to other genes, they may have to approach Caribou, says Jacob Sherkow, a professor at New York Law School. "They're going to have to pay handsomely."
Legal battles aside, the new field risks public backlash. In November, Chinese scientist He Jiankui announced he'd used Crispr to tinker with the genomes of human embryos born as twin girls, thereby heightening pressure on Crispr scientists to consider the ethics of how they're using the life-altering tech. Caribou's license agreements include language to prevent its use on human embryos, Haurwitz says.
Doudna says researchers need to vet the science of editing the genes of embryos, and then people need to discuss how to use it responsibly. "Are there real unmet medical needs that would require this kind of editing or not? I think that's one question."
Debate over the answer will shape Crispr's path to commercialization, one that holds immense potential for its youthful founders—and the likelihood of yet more controversy and conflict.
-Michela Tindera;Forbes Staff
-Ellie Kincaid;Forbes Staff
Related Topics:biochemistbioscienceBiotechcrisprDNA editingFeatured
'A Tweet Can Tank An Economy'
Amazon Surpasses Walmart As The World's Largest Retailer
Everything You Need To Know About The Future Of Pesticides And Bees
Seeing a bee in the city often results in panicked humans running away out of fear of being stung. But the bees are likely less interested in humans than they are in the wildflowers they're circling around, which are likely a safe and pesticide-free place for the bees to feed. Contrary to what we might assume, researchers have found that urban bees tend to live healthier lives than rural ones — they reproduce more, have more food stores, encounter fewer parasites and live longer.
Pesticides are a tricky topic — while they are great for the crops they are meant to protect, they harm the bees that agriculture relies on. Their use sparked debate at the Forbes 2019 AgTech Summit, where beekeepers discussed the impact of these chemicals for bees, and the potential research still needed to understand their effects, and how technology, urban settings and regulation will affect the future of pollinators. Here's everything they said — and you need to know — about how pesticides affect bees.
What are pesticides, and how do they affect bees?
Farmers have traditionally used pesticides to control pests like weeds, insects, mold and mildew and animals like rats and mice, according to the National Institute of Environmental Health Sciences. But they weren't supposed to affect bees, who are critical to our food system — their pollination impacts every third bite of our food, according to the Pesticide Action Network, a nonprofit that challenges pesticide use in farming.
The most harmful chemicals to bees are known as neonicotinoid pesticides. Scientists have found that bees can be poisoned by flying through a field sprayed with the chemicals, but usually bees find harm through drinking contaminated pollen, nectar and water over time, according to PAN. Exposure to these pesticides can detrimental harm to bees over time, weakening their immune systems, shortening their adult life cycle and increasing their disorientation, and could be a cause for Colony Collapse Disorder. While the U.S. Environmental Protection Agency banned 12 types of neonicotinoids in May — from companies Syngenta, Valent and Bayer — there are still 47 more types on the market.
Can technology help with pesticides use?
There's lots of startups looking into technology to change pesticides use and how we define them, especially in Europe, said Dr. Fiona Edwards Murphy, co-founder and CEO of ApisProtect. Her company, based in Ireland, utilizes machine learning to gather data about bee hive health. But Carly Stein, founder of Beekeeper's Naturals, said that to completely rely on these new solutions for pesticides wouldn't necessarily be the right solution. "To think there is going to be a pesticide outlet that's not going to be damaging in some way, shape or form is just a little bit naive," Stein says.
If anything, removing pesticides all together could mean growers would have to resort back to older methods of pest control that could potentially be more harmful to the bees, says Stein, who was listed on Forbes' 2019 30 Under 30. Instead, there should be further research into how pesticides interact with other chemicals, and the subsequent effect on bees. Her company — whose mission is to reinvent the medicine cabinet with bee-based products —outsources its production to regions with no pesticides use like Canada, and conducts third-party pesticides testing on all its raw materials to produce its organic products.
From left to right: Moderator Chloe Sorvino, Timothy "Paule" Jackson, Dr. Fiona Edwards Murphy, Carly Stein and Ellie Symes speak about pollination at the 2019 Forbes AgTech Summit.MATT KANG FOR FORBES
How can urban beekeeping help?
But there are locations that are more sustainable for beekeeping, though, and they might not be where you predict. Timothy "Paule" Jackson's nonprofit, Detroit Hives, builds urban bee farms in abandoned lots in Detroit, Michigan. By planting wildflowers, it provides bees a safe place to feed with little to no pesticides, Jackson said. "We have so many bees where wildflowers are sprouting, and we're not spraying any chemicals on these wildflowers that they are actually boosting the native bee population," Jackson says.
Stein mentioned that urban bees are often healthier than wild bees because of urban bee farms like Detroit Hives. While she loves meeting urban beekeepers, the issue is that there aren't enough of them to sustain commercial production in the U.S., she says.
How can growers help beekeepers?
While there may be no immediate solution to pesticides, what's needed is a stronger line of communication between beekeepers and growers, said Ellie Symes, CEO Of The Bee Corp and winner of the THRIVE Sustainability Award. She's noted that her company has actually started working closer with growers, helping bridge the gap of education between the two groups of agricultural workers. It's helpful for at least beekeepers to know what crops are being sprayed with pesticides and when, she says.
"We are starting to see the different players working together, the chemical companies getting involved and being interested and that's what matters," Symes says. "We'll figure this issue out, but everyone's gotta be involved."
=Haley Kim; Forbes Staff
The Anatomy Of A Fake Cryptocurrency Trade: How Exchanges Create Phony Transactions
Take a close look at trading activity on BKEX—a cryptocurrency exchange founded in 2018 and registered in the British Virgin Islands—and you'll see something odd. Compare its transactions side-by-side with those of Binance, one of the largest crypto exchanges in the world, and you'll notice BKEX's trading history is a replica, printing the same numbers delayed by a few seconds.
According to CoinMarketCap, BKEX has $1.1 billion in daily volume, making it the 20th-largest exchange on the planet. Yet it seems to be simply copying Binance's trade history and passing it off as its own, in perhaps the laziest attempt in history to fool people into thinking it's a lively place to trade digital assets.
A new report by Alameda Research, a 20-person crypto trading firm with offices in Hong Kong and Berkeley, California, reveals a clever set of tricks used by crypto exchanges to fabricate volume.
In the wake of other reports on phony trades, including one by digital asset manager Bitwise indicating that 95% of all transactions are bogus, Alameda felt it could create better research by leveraging its trading data and experience.
READ MORE | Is Forex A Scam Or Money Goals?
The startup was cofounded in 2017 by Sam Bankman-Fried, 27, an MIT alum and former trader at high frequency trading outfit Jane Street. Gary Wang, 26, a fellow MIT grad and former Google software developer, is his cofounder. The firm has $100 million in assets, and over the past month it has traded $1 billion a day on average, making it one of the largest crypto trading firms in the world.
Exchanges make money by charging users to trade, and they have many reasons to artificially inflate volume. More activity means a higher rank on the still-popular website CoinMarketCap, which can attract new users.
Exchanges also charge fees to new cryptocurrency projects that want to get listed in their marketplace, and the perception of popularity helps them command higher rates. Since an exchange's place of business is just a website or an app, and many located outside the U.S. are unregulated, it can publish any numbers it wants and call them trades.
Meanwhile, CoinMarketCap continues to insufficiently vet exchanges' transaction volume, often taking companies at their word and publishing dubious numbers.
According to Alameda's research, another method exchanges use to juice their statistics is sneaking in large, fake transactions amid a flurry of smaller ones. CoinEgg, a Hong Kong-registered exchange that trades $1.1 billion a day reported by CoinMarketCap, recently employed this tactic with litecoin (LTC) trades.
During a period when Alameda observed 15 different offers to buy and sell litecoin in a maximum quantity of 134 LTC, several trades printed as large as 2,000 LTC, as if a buyer appeared out of thin air.
Trading marketplaces typically publish their "order book," showing a list of bid prices at which people are willing to buy an asset, plus a separate set of offer prices where people are willing to sell.
READ MORE | How Cryptocurrency Scams Work
For instance, Bill might be willing to buy bitcoin at $10,000, while Mary wants to sell at no less than $10,050. For a trade to happen, a new buyer must be willing to pay the $10,050 that Mary is offering, and the vast majority of trades that clear will align with orders that previously showed up in the order book, unless two users place offsetting orders at the same exact time.
Yet on some exchanges, trades get executed at prices and sizes that fall outside anything sitting on the order book. On Digifinex, a Singapore-based crypto trading venue, Alameda observed bids and asks for bitcoin between $8,296 and $8,298, but several trades printed at $8,290 and $8,293, prices lower than what anyone was willing to sell at.
On LAToken, a Moscow digital exchange, Alameda saw bids and offers with a maximum size of 1.6 bitcoin in the order book. Implausibly, several trades sailed through at sizes up to 20 bitcoin. LAToken founder Valentin Preobrazhenskiy says his platform only has a "tiny share" of 20-bitcoin orders and that exchanges use inflated volumes as a marketing tool.
"The situation would change when large exchange-ranking sites would add a section for trading volumes based on trades reported to regulators," he says. On Singapore-based ABCC, the best bid and offers Alameda saw were for sizes less than one ether, yet several transactions materialized with sizes of up to 11 ether.
Among trading venues, there's also the well-worn method of simply printing transactions that fall in the middle of the bid and ask prices, which Alameda's research spotted in IDAX and Coineal. In total, Alameda's report gives examples of fishy trading patterns on 60 different crypto exchanges. Aside from LAToken, none of the exchanges named above responded immediately to Forbes' request for comment.
The methodology behind Alameda's research was to test each exchange on six different criteria. First, they manually looked at an exchange's order book and observed where trades printed. If more than 10% of transactions didn't appear on the order book, it failed on this dimension. Another test involved observing the percent of an exchange's trades that took place at the best available bids or offers.
A third criterion was to analyze how much Alameda itself traded on a given exchange, since the startup deals in "virtually every cryptocurrency," considers its algorithms "exchange-agnostic" and estimates that it trades 5% of all global crypto volume.
"If we trade more than .5% of an exchange's reported volume, we consider that exchange to pass according to this criterion," the report reads. For more details on its methodology, see the full report.
Beyond exchanges' bad behavior, the report has other provocative insights. It claims that crypto—including both "spot" trades of actual digital assets and derivatives, like bitcoin futures—trades $38 billion in real volume a day, and 87% of that happens on Asian exchanges, with just 9% happening on U.S. venues. The strict regulatory environment in the U.S. is likely a contributing factor in Asia's dominance, Alameda says.
Compared with Bitwise, which released a follow-up fake volume reportin May 2019, Alameda thinks more crypto volume is real. For large exchanges like OKEx and Huobi, which were founded in China, Alameda estimates about 70% of their transactions are authentic.
Bitwise is much more skeptical, as is the Blockchain Transparency Institute, which has estimated that more than 60% of Huobi's volume is fake and more than 90% of OKEx's volume is fabricated.
A Huobi spokesperson says it doesn't engage in wash trading, but that it has observed some market-makers doing so on its platform, and it takes steps to stamp them out.
An OKEx spokesperson says the company isn't involved in and doesn't tolerate wash trading, adding, "Recently we have joined the Data Accountability & Transparency Alliance (DATA) led by CoinMarketCap, as a commitment to reveal as much data as possible."
-Jeff Kauflin; Forbes Staff
Circular Economy: Doing More With Less
From waste to wealth, circular economic models go beyond the 'take-make-dispose' principle to ensure more sustainable supply chains and products that have a second life.
The traditional economy is built on the idea of "take, make, dispose". It's linear, economically inefficient and unsustainable. But in a circular economy, companies look to take end-of-life products and push them back into the economy as a resource.
It's a circular economic model that aims to keep resources in use for as long as possible, to extract the maximum value from them while in use, and to recover and regenerate products and materials at the end of their service life.
"So you're continually using these resources and not using the planet's finite resources," explains Kirstie McIntyre, Global Director for HP Inc.'s social and environmental responsibility operations.
McIntyre is also a founding member of the Ellen MacArthur Foundation, a global organization focused on promoting the concept of a circular economy.
READ MORE | #30Under30: Technology Category 2019
"There are some big challenges in sustainability. There are challenges now, and they will be more acute in the future," McIntyre says. "It also means companies need to question and innovate in fundamental ways. This isn't just about a little bit of recycling."
Circular economy theory questions how we can maintain a thriving economy within the limits of the planet, taking both resource depletion and climate change into account.
"When you work in sustainability, it can be quite depressing. There are plenty of smart people doing space exploration; Elon Musk is one of them. But I don't think we can afford to wait for Elon Musk to find another planet for us to pull resources from, I think we've got to get on with this now, ourselves," adds McIntyre.
HP's framework revolves around doing more with less. It's about moving away from simply recycling and into a functional circular economy. And it's more than eco-printing for a "forest-friendly" future where more trees are planted than are cut down to enable printing operations.
"There are big sustainability issues in front of us. We have a large responsibility because we're leaders in our industry. It's about ensuring our products, where possible, have a second life. When that's not possible, they're taken apart so we can use the components," says McIntyre.
Innovations that matter are innovations that have a positive impact. HP is just one of many companies working towards the idea of a circular economy; in 2018, trans-national consumer goods company Unilever revealed that its sustainable brands grew 46% faster than the rest of the business, delivering 70% of its sales growth.
Caroline Laurie is the Head of Sustainability at Kingfisher. In a digital-first world where transparency and provenance are becoming increasingly prevalent, Laurie believes that businesses can actually benefit from becoming more sustainable.
"Sustainability drives you to think differently about your business. Customers' expectations of big business are getting higher, yet their trust in big business is getting lower. You'll very rarely find consumers making a choice between two products. But what they want to know is that you've made that choice for them. It is often about range editing. Customers want to trust in brands to do the right thing," explains Laurie.
In other words, sustainability done right brings consumer trust, and with it business, commercial, social, and environmental benefits.
"None of us can solve these issues on our own in isolation. This is about complete value chain re-engineering. This isn't about philanthropy anymore, it's about real commercial sense," ends Laurie.
Caroline Laurie – Head of Sustainability at Kingfisher. Picture: Supplied
The war on plastic straws
Coffee shops are turning to glass and paper as alternative sipping options, with some restaurants even offering tubes of pasta as an alternative, more sustainable solution to the traditional plastic drinking straw. There's a war on plastic straws, and it is the start of both companies and consumers becoming more conscious of the use, reuse, recyclability and disposal of plastics… but is our focus wrong?
"Customers rarely understand the relative environmental impact of different types of materials," says Andrew Smith, the CEO and co-founder of Yuppiechef, the kitchen-focused e-commerce website.
"They believe plastic is bad and paper is good, but this is not always true. Plastic is often recyclable and can have very little environmental impact."
Moving away from single-use plastic – and applying the principles of the circular economy – the New Plastics Economy initiative was formed towards the end of 2018 with the over-arching goal that plastics never become waste. The organization believes that instead they should re-enter the economy as part of products made from recycled plastic material wherever possible.
Digital twins?
Technology has a massive role to play in creating a greener supply chain. For many, this means the use of artificial intelligence (AI), virtual reality (VR), and digital twins. A 'digital twin' is a 1:1 digital copy of a product, process or service, used to provide deep technical training on a device or service without requiring a physical representation of said device or service. According to research and advisory company Gartner, 50% of large industrial companies will use digital twins by 2021.
Jason Ried is the Founder and Managing Director of Fuzzy Logic, an innovative software development company based in South Africa's Western Cape province that has created digital twins of large machinery for mines and automotive and healthcare companies.
READ MORE | Forbes Africa #30Under30 list: Business, Technology, Creatives and Sport
"Using augmented reality solutions on mobile devices or headsets (like Microsoft HoloLens), we allow users to 'see' a digital representation of the machinery they're being trained on as if it was really there," explains Ried.
"Users can get a sense of the scale and design without needing the real thing in front of them. They are able to assemble and disassemble the machine as many times as required to fully learn its intricacies, while each action is digitally tracked and stored, allowing management to understand how well each user performed."
From a sustainability point of view, there are major benefits in the creation and use of 'digital twins' in business: not only do digital twins save time and money, they enhance learning by increasing the quality of training and retained knowledge.
Once digital twins are integrated into business workflows, companies like Fuzzy Logic can further enhance productivity by overlaying digital data onto physical objects.
"Users might, for instance, see steps to repair a part, while info like current temperature and pressure display alongside the machine, updating in real time as users interact with it. This strengthens the link between digital and physical objects," he says.
Jason Ried the Founder and Managing Director of Fuzzy Logic. Picture: Supplied
Ultimately, the concept of a circular economy is about doing more, with less. Gartner's Managing Vice President, Steven Steutermann, says it best:
"The goal is to deliver customer value with minimal waste," Steutermann says. "For such a system to be efficient, it must be automated, and this is where the previous factors come into play. Using technologies such as digital twins and AI in an automated fashion enables the supply chain to execute against circular economy principles by acting on its own and ultimately becoming its own ecosystem."
-Tiana Cline


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Join us for The Charlotte Museum of History's 2019 Mad About Modern Home Tour. Back for its 8th year this fall, the tour gives attendees insider access to a curated collection of private homes representing some of the best examples of midcentury + modern architecture and design in the Queen City.
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Charlotte Museum of History
The Museum presents the Mad About Modern Home Tour to celebrate and foster an appreciation for Charlotte's unique midcentury + modern architectural history as part of our mission to advocate for the preservation of Charlotte's historic built environment.
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Home » World News » England records 13 Covid deaths but full figures won't be released
England records 13 Covid deaths but full figures won't be released
England records 13 more coronavirus deaths in hospitals – but the full daily figures won't be released for first time amid questions over their accuracy
13 people who tested positive for COVID-10 have died in hospitals in England
NHS England said today the patients were aged between 46 and 96
Full figures will not be published today for the first time during the pandemic
Oxford academics believe the number of coronavirus deaths has been inflated
Thirteen people who tested positive for coronavirus have died in hospital in England today, bringing the total number of confirmed deaths in hospitals to 29,173.
NHS England said this afternoon the patients were aged between 46 and 96 years old and all had known underlying health conditions.
But full figures will not be published today for the first time during the crisis after Matt Hancock ordered a review into claims by academics the number of coronavirus deaths recorded in the UK during the pandemic had been exaggerated.
Oxford University experts have claimed the Government's official count of COVID-19 deaths has been inflated and fewer than 40 people per day are now dying.
They say that the way officials count the death of anyone who has previously tested positive for coronavirus – even if it is months ago – gives a misleading picture.
A message on the Government's website said: 'Currently the daily deaths measure counts all people who have tested positive for coronavirus and since died, with no cut-off between time of testing and date of death.
Dr Jason Oke and Professor Carl Heneghan, from the University of Oxford, said death figures published by Public Health England contained 'inaccuracies' and could cause confusion.
Health Secretary Matt Hancock, pictured in the House of Commons on Thursday, has ordered an urgent review into how the numbers are calculated
The announcement posted on the Department for Health website regarding death statistics
Dr Loke's analysis shows that 'all settings' deaths (red bar) remain very high in England even as hospital deaths (blue bar) – which the Office for National Statistics says should make up two thirds of the total – have plummeted
Data shows that the trend of deaths charted by when they actually happened (dotted blue line), not when the paperwork was finished, is significantly lower than the number of deaths being announced by the Department of Health (red line)
HOW MANY PEOPLE HAVE REALLY DIED OF COVID-19 IN THE UK?
Department of Health: 45,053
Department of Health's latest death count for all settings (as of 9am, July 15) stands at 45,053.
The daily data does not represent how many Covid-19 patients died within the last 24 hours – it is only how many fatalities have been reported and registered with the authorities.
It also only takes into account patients who tested positive for the virus, as opposed to deaths suspected to be down to the coronavirus.
National statistical bodies: 55,216
Data compiled by the statistical bodies of each of the home nations show 55,216 people died of either confirmed or suspected Covid-19 across the UK by the end of May.
The Office for National Statistics yesterday confirmed that 50,219 people in England and Wales died with confirmed or suspected Covid-19 by June 19.
The number of coronavirus deaths was 824 by the same day in Northern Ireland, according to the Northern Ireland Statistics and Research Agency (NISRA).
National Records Scotland – which collects statistics north of the border – said 4,173 people had died across the country by June 22.
Their tallies are always 10 days behind the Department of Health (DH) because they wait until as many fatalities as possible for each date have been counted, to avoid having to revise their statistics.
Excess deaths: 65,249
The total number of excess deaths has now passed 65,000.
Excess deaths are considered to be an accurate measure of the number of people killed by the pandemic because they include a broader spectrum of victims.
As well as including people who may have died with Covid-19 without ever being tested, the data also shows how many more people died because their medical treatment was postponed, for example, or who didn't or couldn't get to hospital when they were seriously ill.
Data from England and Wales shows there has been an extra 59,324 deaths between March 15 and June 12, as well as 4,924 in Scotland between March 10 and June 22 and 1,001 in Northern Ireland between March 28 and June 26.
'There have been claims that the lack of cut-off may distort the current daily deaths number. We are therefore pausing the publication of the daily figure while this is resolved.'
Dr Jason Oke and Professor Carl Heneghan said figures from Public Health England – which have been published each day by the Department of Health – contained 'inaccuracies' and could cause confusion.
Deaths are still falling, the professors said, even if at a slower rate than they were earlier in the crisis.
The Government has pointed out in the past that it counts deaths on the date that the paperwork is completed, not when the person actually died, which can make day-by-day figures inaccurate. Numbers are particularly low at the weekends and on bank holidays.
Dr Oke and Professor Heneghan said the Government should make it clearer when people actually died so that when there are one-day spikes – the 138 deaths announced on Tuesday, for example – it doesn't look like the outbreak is getting worse.
Writing in a blog Dr Oke and Professor Heneghan said: 'What has become apparent in recent weeks is the growing disparity between the numbers released by ONS [Office for National Statistics] and those reported by Public Health England which are widely disseminated in the media.'
They said PHE's figures 'vary substantially from day to day' and explained: 'This variation is most likely due to the appearance of 'historic' deaths that have occurred weeks before, but for some reason unknown to us, get reported in batches on particular days.
'To counter this variation, a moving average smooths the trend, but even this is at odds with the ONS data…
'We can surmise that the total number of deaths in all settings is approximately 40 per day, much closer to the ONS numbers.'
To explain their calculations Dr Oke and Professor Heneghan, from the university's Centre for Evidence-Based Medicine, compared death tolls recorded by Public Health England (PHE) and the Office for National Statistics (ONS).
PHE counts only deaths in people who tested positive for Covid-19, which means it is thought to have missed out thousands of people at the start of the epidemic.
The ONS, meanwhile, counts anyone who has the disease mentioned on their death certificate, whether they were tested or not.
Dr Oke and Professor Heneghan said even PHE's moving average, which is intended to smooth out dips and spikes around the weekends, is too high.
It was 103 for June 30, they pointed out, but the ONS counted 101 deaths (by actual date of death) on June 30 and July 1 combined – making the two-day average 51.
They said: 'The PHE figures average has been consistently higher than ONS for some time.'
The pair also pointed out the death counts from NHS England, which are accurate around three days after the date in question, are too low to match PHE.
According to the ONS, hospital fatalities now make up around 60 per cent of all deaths that happen on any given day.
On June 30, NHS England recorded 27 fatalities. If this was 60 per cent of all deaths that happened on that day the total number would be 45.
But the Department of Health, using PHE's data, announced 115 more deaths on that day.
Professor Heneghan and Dr Oke acknowledged that the official death counts are constantly backdating deaths so do not reflect the day they're announced, but suggest that historic fatalities are being spread out.
'Because of the inaccuracies in PHE data we recommend using ONS data and the NHS England data to understand the trends in deaths over time,' they wrote.
'To reduce confusion we require all deaths reported by PHE to include when they occurred as opposed to the day of reporting.'
A Department of Health and Social Care spokesperson said: 'We have been completely up front about how this information is being presented, and it is misleading to suggest that there are discrepancies or inaccuracies in the data.
'These data sources are all subject to time lags in reporting, and DHSC and PHE have been clear that figures reported at weekends are sometimes lower for that reason.'
BRITAIN'S OUTBREAK IS STILL SHRINKING BY 5% A DAY – BUT R RATE MAY BE ABOVE 1 IN LONDON AND THE SOUTH WEST, SAGE SAYS
Britain's coronavirus outbreak is still shrinking by up to 5 per cent a day, according to official data – but SAGE has warned the R rate could be above one in the South West of England and London.
The Government's scientific advisory panel revealed the UK's current growth rate – how the number of new cases is changing day-by-day – is between minus five and minus one per cent.
It is more confirmation the crisis is still petering out and suggests the reopening of pubs, restaurants, hairdressers and beauty salons on July 4, dubbed 'Super Saturday', has not triggered a resurgence yet.
But the figures show the UK's outbreak is now be shrinking at a slightly slower speed because the growth rate has crept up from last week's rate of minus 5 per cent to minus 2 per cent per day.
Scientists today said they were 'cautiously optimistic' about the data, which they say shows 'there is no indication the epidemic has gotten out of hand as a result of the easement' of lockdown.
But they warned Brits 'must stay completely vigilant' because a lag in the statistics means it is at least two weeks behind and it could take until next week for any spike to become visible.
Separate figures released by SAGE show the virus's reproduction rate – the average number of people each Covid-19 patient infects – is still between 0.7 and 0.9 as a whole for the UK, meaning it hasn't changed in two months.
But SAGE admitted the R could be as high as 1.1 in the South West of England, where Britons have been flocking for stay-cations to enjoy the coastline of Cornwall, Devon and Dorset, and in London, where pubs have been rammed with customers after reopening earlier this month.
For England as a whole, the R is slightly higher than the rest of the country, with the reproduction number hovering between 0.8 and 1. Keeping the rate below one is considered key because it means the outbreak is shrinking as not everyone who catches it passes it on.
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British lesbian couple become first in world to have baby using BOTH their wombs – The Sun
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A 'Surprise Informant' Has Surfaced In Tekashi 69's Racketeering Case Causing Concern For His Lawyers
Aaron Williams
Hip-Hop Editor
There's good news and bad news for incarcerated Brooklyn rapper Daniel Hernandez, aka Tekashi 69, aka 6ix9ine. While plugged-in video blogger Akademiks reported that his formerly-postponed album, Dummy Boy, may see release as early as today, TMZ reports that prosecutors in his racketeering case have produced a confidential informant, further causing concern for his legal team.
While Tekashi pled "not guilty" to the extensive list of charges against him and was given a court date almost a year away, prosecutors revealed they've cultivated a series of recordings — and not the kind rappers should be known for — with the help of a confidential informant. Tekashi's lawyer, though confident that any conversations that may have been recorded of his client will paint a picture that he was not really in as tightly with his co-defendants as prosecutors say, did admit that, "Anytime there is a confidential informant, there is cause for concern."
He continued, "I am confident that any recorded conversations with [Tekashi] will prove that he was never a part of the Enterprise and support the conclusion that he's innocent." Unfortunately for Tekashi he'll have to wait almost a year to find out if that's true; in the meantime, he's been transferred out of his original facility to one used for witness protection for safety while his lawyer plans to appeal directly to the judge for bail.
TAGS6ix9ineTekashi 69


Well, it's official. I'm a twit. Meaning that after resisting for more than a year, I'm now on Twitter. I resisted for so long because I thought it was a silly fad that would die out soon enough. I did the same thing with Facebook when it debuted in 2004, and anyone who's friends with me on it now knows I can't go three hours without checking the damn thing.
But, alas, it's becoming increasingly clear that Twitter isn't going away. It's become a mainstream medium for communicating about everything, from angst-ridden teenagers complaining about their parents not letting them go to a Weezer concert (that never happened to me, I swear) to newspapers spreading the latest breaking news.
I first realized Twitter may actually be a relevant (and succinct, which I can't complain about) form of communication after it actually proved itself useful following Iran 's crack down on traditional journalists and media in wake of its controversial election last June. And now, when you Google a hot news or pop culture item, a scrollable feed with the latest Twitter results pops up, regardless if you tweet or not.
Anyway, since there's really no escaping the Twittersphere, I decided to just jump on the bandwagon and get it over with. You can follow me, if you so desire, as ALSquires29. I promise I won't pull a Thumper on you.


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Cover Reveal│Set Me Free by Melissa Pearl
Release Day May 18th!
Hunted by a crooked FBI agent who killed her parents, Lucy has taken on one disguise after the next.
But Zach knows exactly who she is and in spite of mounting evidence indicating her guilt in her parents' death, he knows she's innocent.
Convinced that it's time to put her years on the run behind her, Zach and Lucy vow to fight back, clear her name, and take down the real killer.
With support from Zach's loyal friends and his uncle, an investigative reporter, they set out on a dangerous mission hoping that the truth...will set them free.
Pre Order Set Me Free!
( Releases May 18th 2014 )
Haven't read book #1 yet?! Grab it today!
Lucy Tate is on the run. After witnessing the brutal murder of her parents, she's spent five years in hiding -- taking on different personas and faking her way through life. The authorities can't be trusted, so she remains in the shadows, always one beat ahead of the man who is forever hunting her. That is, until she meets Zach Schultz, a senior at Monte Vista High and the one guy she can't bear to leave. Suddenly her natural instincts to lie, steal, and run are overshadowed by something else...the desire to stay. It's her
one shot at a normal life.
Curious by nature, Zach is immediately drawn to the new girl at school. How can a person look both confident and vulnerable all in the same moment? Determined to learn more about her, he tries to get close, but is thrown into a world of lies and confusion. The only thing that becomes apparent is that discovering the truth may get him killed.
My Review for I Know Lucy
Website / Facebook / Twitter / Goodreads / Author Blog / Book Blog / Pinterest
Sign up for Melissa's Newsletter
Melissa Pearl was born in Auckland, New Zealand, but has spent much of her life abroad, living in countries such as Jordan, Cyprus and Pakistan... not to mention a nine month road trip around North America with her husband. "Best. Year. Ever!!" She now lives in China with her husband and two sons. She is a trained elementary teacher, but writing is her passion. Since becoming a full time mother she has had the opportunity to pursue this dream and her debut novel hit the internet in November 2011. Since then she has continued to produce a steady stream of books. Recently she signed with Evatopia Press and her first Evatopia book is coming out in February 2014 - True Colors, The Masks Series #1. She is very excited to be trying out new things this year while continuing to publish under her own name as well. She has six books planned for 2014 and is excited about writing each and every one of them.
"I am passionate about writing. It stirs a fire in my soul that I never knew I had. I want to be the best writer I can possibly be and transport my readers into another world where they can laugh, cry and fall in love."


How to benefit from autonomous systems in heavy industry?
In heavy industry, change has always come slowly. However, fast-evolving enabling technologies for remote-operated and autonomous systems have brought a sudden shift in gear and a whole new value proposition.
In mining, farming and forestry, for example, autonomy is already revolutionizing our ability to harvest natural resources safely, sustainably and affordably. Accompanying this is the mega shift away from manual workloads in lonely and remote locations and the return of our workers to regular hours in safe, social environments.
Automation is no longer something that happens in fenced-off isolated work areas and cost is no longer a barrier for entry. The advent of technologies like artificial intelligence, connectivity and sensor solutions are bringing down operational barriers and costs that can change your game.
Safety standards and operating principles are also keeping pace, allowing humans and autonomous machines to work alongside each other, evolving together into new ecosystems that make the best business sense, bringing safety and savings. But the conditions have to be right!
How VTT can help you to automize your business?
In building these new autonomous machines ecosystems, our expertise is in designing and defining the right approach for your business, as well as choosing the right tools and methodology.
This doesn't have to happen overnight! Your journey to autonomy can be gradual. Small steps can still bring big shifts, particularly for small- and medium-sized companies, or locally large businesses, bit-by-bit gaining a competitive edge.
If you're in farming, forestry, or quarry work, think how the addition of just four or five machines into an autonomous fleet could advance your chances of tendering a winning offer or contract; or how adding just a small amount of autonomy to any large logistical system like underground mining, logging or container shifting could have an immediate effect on your business bottom line.
The technology door is open now. We can help you run through it or walk – but staying still is not an option!


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Q: PHP: Column count doesn't match when importing CSV file with empty cells/columns I have a code that will allow users to import/insert data into database from the CSV file. the problem is that if there is an empty columns or cells from the CSV file, it will display an error telling me that the column count doesn't match value count at row 1. I tried to assign a value in the empty cells/columns of the CSV file and it successfully uploaded. How can I allow the users to upload a CSV file even if there's an empty columns/cells? Below is my code.
            if ($handle) {
                $counter = 0;
                $sql ="INSERT IGNORE INTO bill_of_materials(allotment_code, category_name, activity, quantity, unit, description, end_unit_quantity, unit_cost, regular_labor_cost, end_unit_labor_cost, type, batch) VALUES";

                while (($line = fgets($handle)) !== false) {

                    $sql .= "('".implode("', '", explode("|", addslashes(str_replace('"', '', $line))))."'),";
                    $counter++;
                }

                $sql = substr($sql, 0, strlen($sql) - 1);

                 if (mysqli_query($new_conn, $sql) === TRUE) {

                    $message = 1;

                } else {

                    echo mysqli_error($new_conn);
                }
                fclose($handle);

here is my table:

and here's the csv file:


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JLL is Asia Pacific's top real estate dealmaker for 7th consecutive year
Real Capital Analytics puts JLL on top in five categories for 2017.
JLL has been named number one real estate investment advisory firm in Asia Pacific for the seventh consecutive year by Real Capital Analytics (RCA), an independent body that monitors real estate transaction volumes worldwide.
According to RCA, JLL has achieved the highest value of investment deals in Asia Pacific, a total of US$26.8 billion in 2017, accounting for 29.8 per cent of total market share. Out of the seven asset types included in the ranking, JLL took the top spot in five categories – office, retail, apartment, development site and hotel.
"It's an honour to be recognised by RCA for the seventh time in a row. We're also thrilled to have moved up to first place in the office sector this year – testament to the great work done by the teams across the region," says Stuart Crow, Head of Asia Pacific Capital Markets, JLL. "We'd like to thank our clients, whose trust in us has allowed us to reach this landmark. We will continue to work closely with them to achieve their goals."
He adds: "2017 saw a number of mega-deals in Asia Pacific, highlighting a strong interest in the region's high potential. This is a positive indication that demand from global investors is set to increase so we look forward to some significant deals this year."
JLL Philippines Country Head Christophe Vicic highlights that here in the country, JLL remains to be known as the leading professional services firm that specializes in real estate and investment management. The Hotels & Hospitalities sector meanwhile, represents a fast-growing opportunity for JLL in the Philippines. "Our track record for office leasing speaks for itself. It's only fitting that that regionally, JLL is on top." He adds, "We've always seen hotels and hospitality as an area with much potential, and with this achievement, we've cemented our place as the best company to foster that growth in the Philippine market."
For more information on RCA's methodology, visit http://www.rcanalytics.com.


Davies & Rose Rural & Hardware is a family owned business that has been trading for over 30 years. We are your local rural and hardware store based in Creswick. We service Creswick and surrounding towns incuding Ballarat, Clunes, Sulky, Daylesford, Ascot, Blowhard Waubra, Addington, Learmonth, Coghills Creek, Smeaton, Broomfield, Dean, Clarkes Hill, Newlyn, Rocklyn, Barkstead, Blampied, Kingston, Allendale, Bald Hill and beyond.
We are proud to be your CRT local bloke, specialising in all your farming needs. We have agronomists who specialise in broad acre, pasture and horticultural crops. Along with the CRT we are also a Home Timber & Hardware store. We offer a large range of hardware products to suit all your building and DIY needs. So you can go where the tradies go, Home Hardware.
Call in and visit us in store. You will find easy and convenient parking and be guaranteed great service by our friendly staff members.
After a prolonged wet and cold period, now is the time to be looking at controlling broad leaf weeds in cereals and pastures. Please contact our agronomist Andrew for weed control advice.


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Der heilige Bartholomäus von Simeri (* nach 1050 in Simeri (CZ); † 19. August 1130) war ein italo-byzantinischer Mönch und Gründer des Klosters S. Maria Hodogetria bei Rossano.

Zunächst lebte er als Eremit in Kalabrien. Mit Unterstützung des Admirals Christodoulos und der Regentin Adelasia reformierte er das Kloster S. Maria Hodogetria bei Rossano in der Verbindung von morgenländischen und abendländischen Traditionssträngen. Die Voraussetzung für das Gelingen war die Autonomie vom griechischen Erzbischof von Rossano, die ihm von Paschalis II. 1105 mit der Gewährung der Romunmittelbarkeit geboten wurde. Mit seiner Gründung setzte er ein Beispiel für die erfolgreiche Koexistenz des griechischen Mönchtums mit den neuen normannischen Herrschern.

Ein längerer Aufenthalt auf dem Athos vermittelte ihm Eindrücke des östlichen Klosterlebens. Auf Wunsch Rogers II. bereitete er ab 1121/22 die Gründung von San Salvatore zu Messina vor, die unter seinem Schüler und Nachfolger Lukas zum Abschluss gebracht wurde.

Außer dem Bios (Vita) des Bartholomaios von Simeri berichtet eine Homilie des Philagathos von Cerami über Leben und Tugenden des Heiligen. Philagathos ist vermutlich auch der Verfasser des Bios.

Literatur

 Gaia Zaccagni: Il Bios di san Bartolomeo da Simeri. In: Rivista di studi bizantini e neoellenici. n.s. 33, 1996, S. 193–274 (kritische Edition der Vita mit italienischer Übersetzung).
 Stefano Caruso: Il santo, il re, la curia, l'impero, sul processo per eresia contro Bartolomeo da Simeri (XI–XII sec.). In: Bizantinistica 2. Ser. 1. 1999, 51–72.305–349;
 Gaia Zaccagni: Considerazioni sulla paternitá del Bios di san Bartolomeo da Simeri. In: Liturgia e agiografia tra Roma e Costantinopoli. Atti del I e II seminario di studio, Roma, Grottaferrata 2000–2001. Cur. Krassmir Stantchev – Stefano Parenti. Grottaferrata 2007, 33–44.

Einzelnachweise

Heiliger (12. Jahrhundert)
Person (Byzantinisches Reich)
Eremit
Abt
Person (Religion, Sizilien)
Person (Kalabrien)
Basilianer
Geboren im 11. Jahrhundert
Gestorben 1130
Mann

redpajama_set_name: RedPajamaWikipedia