WASHINGTON — A bipartisan measure that would have eliminated funding for federal raids on medical marijuana dispensaries in states where they're legal failed Wednesday in the House of Representatives. The legislation, introduced by Reps. Dana Rohrabacher (R-Calif.), Sam Farr (D-Calif.), Maurice Hinchey (D-N.Y.), and Tom McClintock (R-Calif.), was part of the appropriations bill to fund the Department of Justice for fiscal 2013. It failed 262-163.
The bill came as the administration of President Barack Obama has unleashed an interagency crackdown on the cannabis industry, with raids on pot dispensaries, many in California operating in full compliance with state law. Since October 2009, the Justice Department has conducted more than 170 aggressive SWAT-style raids in nine states that allow medical marijuana, resulting in at least 61 federal indictments, according to data compiled by Americans for Safe Access, an advocacy group. While medical marijuana is legal under laws in 17 states and the District of Columbia, federal law says any use of marijuana is illegal.
None of the funds made available in this Act to the Department of Justice may be used, with respect to the States of Alaska, Arizona, California, Colorado, Delaware, District of Columbia, Hawaii, Maine, Maryland, Michigan, Montana, Nevada, New Jersey, New Mexico, Oregon, Rhode Island, Vermont, and Washington, to prevent such States from implementing their own State laws that authorize the use, distribution, possession, or cultivation of medical marijuana.
Of the 190 Democrats in the House, 134 (more than 70 percent) voted in favor of the bill. Only 29 of the 242 House Republicans (less than 12 percent) did.
"If states' rights aren't a good enough reason to pass this amendment, do it because of compassion. Compassion demands it," said Farr in his statement Wednesday on the House floor. "We offer this amendment for terminal cancer patients," he added, "for AIDS victims, for persons who suffer chronic pain. We offer this amendment not only to protect those people, but we offer this amendment to protect the states that are progressive enough to provide alternative medical options to those who need it."
Watch Farr's address to Congress below.


The best outcome of measuring and reporting city environmental data, is increased and ambitious climate action development and more feasible transition to sustainable economy.
– We encourage all cities in the region to join this shared cause. Firstly because this new and improved CDP reporting platform offers cities an easy way to report city development and environmental plans and data and secondly the responses give the cities tangible results and offer better understanding on their climate transition, not to mention global visibility for them and the whole region" says Mr. Björn Grönholm, head of the UBC Sustainable Cities Secretariat.
Throughout the reporting period, both the CDP and the UBC will be offering guidance and training for the member cities, including a series of webinars to help cities collect and report their climate data. The invitations to UBC member cities will be sent in February and an additional information webinar will be held in April. The reporting period this year will be open from 14 May until 11th July 2018 - the original deadline was postponed from June 20th to July 11th due to finalising the reporting platform.
In the XIV UBC General Conference on 24 –27 October 2017 in Växjö, Sweden, a joint report by UBC and CDP on Climate Leadership from Baltic Sea Region Cities was launched. Read more and download the full report from 2017 at UBC Sustainable Cities Commission website.
UBC's goal is to attract more cities from the region to join this initiative and at the same time help and support them in their transition to become more sustainable economies.


John Keats Forum • View topic - Who'll dare go for this one?
Who'll dare go for this one?
How about a rogue's gallery of members where they can post their photos so we can put a face to a name.
That would really sort out the men form the boys (literally).
Knowing the general reticence of people on the 'net generally, I can't see anyone wanting to be so bold as to give the slightest hint of their real personality.
Are they afriad of being plagued by unwanted e-mails or do they just want to deliberately create a false 'net personality to hide their own deficiencies?
I'm unafraid of telling anything about myself, and have done on this site and others. What are people so afraid of??
What do I care what someone thousands of miles away thinks about what I say? Anyway most people are afriad to give even their own names, or the other things asked for in their profile page.
Come on you bunch of cowardly, cynical, chickens!!
Sounds good, buy me a digital camera and I'm in.


I am very concerned with the proposed amendment to Article III of the hazardous-waste ordinance, which was adopted in the early 1980s and is still a safety valve for the residents of Terrebonne.
The Department of Natural Resources Office of Conservation will have all the power to regulate the sites and their locations. Without local jurisdiction, we will have no say in this matter. The statewide Order 29-B waste site regulation only requires a 500-foot buffer zone. This is a travesty.
Please remember the state issued a permit to build and operate a waste site that contained 4 barges and an injection well located at the present Grand Bois site. Waste was not supposed to touch the ground and any runoff or wet waste would be injected into a closed formation. This is why the ordinance was adopted. We needed local regulations in Terrebonne Parish. The Police Jury took the lead and adopted Article III – Hazardous Waste ordinance, which is the foundation of local protection for more than 100,000 residents and their property.
I wrote this letter to ask the people of Terrebonne Parish to call their council members now and ask them not to vote to amend a law that protects us from having waste sites next door to us. The public hearing is today on this ordinance amendment.
I have no problem with injection wells that are built according to state laws, but I have a problem with the above-ground tanks, clean-out pits and trucks hauling waste in from off-site facilities. Please understand that benzene, toluene, possible radiation and other contaminants cannot be totally contained on site. They will volatilize and come visit our children, wives and ourselves in our nearby homes and yards. A 500-foot buffer zone is a joke. It will not protect the homeowners; it will only protect the site operator. Please remember these sites are commercial-waste sites and can accept waste from anywhere.
I ask you how anyone can propose cutting a mile buffer zone down to only 500 feet. Why would they do this? Why put more than 100,000 people at risk just to allow a few to build these sites so near our homes.
Council members, please vote against the amendment.


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You will need to be kept informed when it comes to Termite Inspection in Palmer, IA. We will ensure you understand what to anticipate. This is exactly why we try to make every effort to be sure that you are familiar with the project and are not facing any kind of unexpected situations. Step one will be to contact us today at 844-244-3120 to set up your work. We are going to discuss your questions once you call and help you get arranged with a scheduled visit. We work with you all through the whole project, and our company can appear promptly and well prepared.
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While work ethic is proven to be one of the key factors for success in life; the struggle with children labour ethic is one of the most common concerns voiced by mothers, teachers, and professionals.
Similar problems are being shared by numerous parents and are also evident in every classroom. Make ethic objections are often links with neurological states. Nonetheless, I am most concerned with the sharp increase of these issues amongst generally developing offsprings. These are the boys I am referring to in this blog.
Work ethic correspond with a muscle. It can be strengthened with proper training or weakened with ill-use. The bad news is that kids' production ethic is in a crisis and we, parents, have a lot to do with it. The good bulletin is that with proper training you can improve your child's study ethic.
Reality: Why are we misleading most children? We are telling our teenagers a fairy tale. We are parent them for the purposes of an artificial reality , not for the real world. Life is not a barbecue. "Were not receiving" magical twig , no golden sheet , no endless recreation. We all are well aware that life is tough. Life is fitted with monotonous task, delayed delight, objections, and responsibilities. It is chiefly about doing what is needed to get what is wanted. "Magic" mainly happens when we pushing ourselves outside of our consolation zone, work hard through the difficulties and boredom.
Outcomes: When bubble wrapping our minors, we have best available intentions in thought to manufacture them joyous. Regrettably, we shape them joyous at the moment, but sad in the long term. Bubble wrapping prevents the development of responsibility, freedom, problem-solving, perseveration, and resilience. By doing so, we rob them of developing the cultivate ethic which is an essential building block for life's success. With best available of intentions in attention, we are leaving our girls unprepared for real life.
2. Incorporate into your child's daily life the' first' and' then' theory to qualify delayed delight and hard work.' First' do what is needed and' then' what is missed 😛 TAGEND ' First' homework,' then' performance;' first' tidy up toys,' then' go outside;' first' carry your skates, then' skating';' first' peel a banana,' then' eat it;' first' make,' then' waste Screen time is not recommended for children under two years old. For juveniles 2 to 5 years old, screen meter restricted to 1 hour a day( see recommendations) Avoid employing gadgets to alleviate wearines during gondola moves, banquets, and while waiting for something Have an unstructured time in your child's schedule and school him/ her to fill the time by making a technology-free task schedule for "I am bored" time. Life abilities such as self-feeding, self-dressing, touching teeth Chores such as making a bed, determining a dinner table, putting unclean invests in the impediment, watering flowers, loading/ emptying dishwasher, feeding a pet, sorting/ folding laundry, and even bathing vehicles. Ex. woodworking, gardening, fishing, sewing, working with clay, ceramic decorate, making a mosaic, coloring by numeral/ complexion, constructing blanket castles, forming handmade greeting placards, and scrapbooking.
Encourage kids to choose their clothes in the morning, push them to make decisions in the restaurants, when shopping for invests and groceries If a dance rolled under a couch, milk get spilled or zipper is stuck, don't haste to assist, promote your child to be resolved Ex. don't accompany forgotten lunch or schedule to school, don't re-buy a lost toy Minimize the use of strollers, incorporate hiking, dive, biking. Explain that boredom is a normal human district, our life contained in activities that we want to do, as well as those that we need to do; Life volunteers defies, and our goal is learning to overcome these challenges rather than running away from them.


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Q: ¿Cómo verificar si 2 elementos consecutivos de un array son iguales en python? Me encontré con un inconveniente con la tarea de poder verificar si 2 elementos ingresados por teclado en un array son repetidos, este es el codigo:
n=3
for i in range(n):
    os.system("color 0f")
    print("Valores ingresados:",i,"de",n)
    A=[input("Valores: ")]
    if i!=0: #Si i=0 entonces no se compara con ningún valor ya que es el primer valor
        if A[i-1]==A[i]: #se compara la posición actual con la posición anterior
            print("Se ingresaron 2 números consecutivos repetidos, ingrese nuevamente valores distintos")

Sin embargo, me esta dando error:
if A[i-1]==A[i]:
IndexError: list index out of range

A: Una forma fácil de saber si dos elementos consecutivos en un iterable es, primero usando zip() el cual crea una lista de tuplas de dos listas.
>>> a = [1, 2, 3, 4]
>>> b = [5, 6, 7]
>>> list(zip(a, b))
[(1, 5), (2, 6), (3, 7)]

Usando ahora comprension para comparar los elementos en cada tupa y finalmente any() devuelve True si cualquier elemento de un iterable es True.
>>> list(i == j for i, j in zip(a, b))
[False, False, False]
>>> any(i == j for i, j in zip(a, b))
False

Aplicando el concepto anterior, lo que necesitas es:
>>> mylist = [1, 2, 3, 5, 5]
>>> any(i == j for i, j in zip(mylist, mylist[1:]))
True

A: no he usado python, pero por logica lo que haria seria:
for int i = 0 ; i < array.length ; i++ {

   if (array[i] != array.lenght) {

      if (array[i] == array[i+1]) { son iguales}

   }else {

      if (array[i] == array[i]) { son iguales}

   }

}

redpajama_set_name: RedPajamaStackExchange


text:
Getting an HIV Diagnosis
There are three types of HIV tests: antibody test, antigen/antibody test, and nucleic acid test. These tests may either use a blood sample or an oral swab.
Tahirah Chichester, MPH
Tahirah is a public health professional with more than 10 years experience supporting people along various stages of their health journey. She has a Master of Public Health in epidemiology and biostatistics from Temple University.
Anju Goel, MD, MPH
Medically reviewed by Anju Goel, MD, MPH
Anju Goel, MD, MPH, is a public health consultant and physician with more than 10 years of experience in the California public health system.
Stefanamer / Getty Images
Human immunodeficiency virus (HIV) is a virus that attacks white blood cells (called CD4 cells) in the immune system. These cells help your body fight infections. HIV kills CD4 cells, causing your immune system to weaken and become vulnerable to other illnesses.
Getting tested for HIV is the only way to diagnose HIV. If left untreated, HIV can cause damage to the immune system and lead to a condition called acquired immunodeficiency syndrome—commonly known as AIDS. Knowing your HIV status can get you started on treatment sooner, help you reduce symptoms, and stabilize the spread of HIV in your immune system.
There are three types of HIV tests: nucleic acid, antigen/antibody, and antibody tests. These tests may use either a sample of your blood or saliva to get results. In some cases, a provider can also use a urine sample. While some HIV tests can detect HIV sooner than others, no HIV test can detect the virus immediately after exposure. At a minimum, it can take 10 days for HIV to show up in a test result.
You can get a test for HIV at your healthcare provider's office, family planning clinics, pharmacies, mobile testing vans, or during HIV/AIDS awareness-related community events. At-home HIV tests are also available for pick-up or purchase in some pharmacies and clinics. If you receive a diagnosis—or a positive test result—these places can connect you to specialists who provide HIV care, knowledge about treatment options, and other social services.
What I Wish I Knew About the Community I'd Have After My HIV Diagnosis
Who Should Get Tested for HIV
HIV testing should be a part of everyone's routine healthcare screening, including people who are pregnant. The Centers of Disease Control and Prevention recommend that anyone between the ages of 13 and 64 should get tested for HIV at least once. You should also get tested for HIV if you have symptoms of acute or chronic HIV.
However, not everyone experiences symptoms and symptoms of acute-stage HIV can mimic flu-like symptoms. Healthcare providers recommend frequent testing (at least once a year) for people who participate in behaviors that increase their risk of acquiring HIV.
These behaviors include:
Being a man who has sex with another man
Having sex with someone who is HIV positive
Having unprotected vaginal and anal sex
Engaging with more than one sexual partner
Receiving a separate diagnosis for sexually transmitted infection (STI), hepatitis, or tuberculosis
Sharing of needles, syringes, or other drug injection equipment.
Getting tested after taking part in these activities is important—as it can detect HIV early and help you get started on treatment sooner.
Where Can You Get Tested for STIs?
Types of HIV Tests
HIV carries an antigen called protein 24 (or just "p24"). Antigens are foreign substances that enter your body that send a signal to your immune system that there is something wrong. When your body is exposed to HIV, the immune system begins to produce antibodies (proteins that help fight the virus).
When you go in for HIV testing, your healthcare provider can offer you three tests: an antibody test, an antigen/antibody test, or a nucleic acid test (NAT). The p24 antigen shows up in HIV tests faster than the antibodies that your immune system makes to fight the antigen. That said, your provider may give you more than one test to confirm an HIV diagnosis.
Each test has a different window period. A window period is the time between when you get the virus and when an HIV test can accurately detect that you have the virus. Because of this, HIV tests cannot detect HIV immediately after you think you may have been exposed to the virus. The earliest an HIV test can detect the presence of the virus is 10 days.
Antibody Test
An HIV antibody test uses a sample of your blood, saliva, or urine to check for HIV antibodies. Most rapid HIV tests and at-home self-tests are antibody tests. This test can detect HIV antibodies 23 to 90 days after exposure to the virus.
It takes about 30 minutes to get your results from a rapid antibody test.
Antigen/Antibody Test
An HIV antigen/antibody test looks for the presence of both HIV antigens and antibodies in your immune system. This is a lab test that involves drawing blood from a vein. An antigen/antibody test can see if you have the virus 18 to 45 days after exposure to HIV.
It may take several days to get results from a traditional antigen/antibody lab test. However, rapid antigen/antibody testing is also available. With rapid testing, you can get a blood sample from a finger stick rather than your vein. But, there is a difference in the window periods and result times between rapid and traditional HIV antigen/antibody tests.
A rapid test has a longer window period than a traditional test and can detect the virus 18 to 90 days after HIV exposure. Results from a rapid antigen/antibody come faster than a traditional test—you can get rapid results in less than 30 minutes via a finger stick test.
Nucleic Acid Test
A nucleic acid test (NAT) looks for HIV in the blood. A healthcare provider takes a blood sample from your vein. They will then send the sample to a lab for proper testing. NAT results can show whether or not you have HIV and your viral load (or, how much of the virus is in your blood).
NAT has a quicker window period than other types of HIV tests. You can get a NAT test 10 to 33 days after exposure to the virus. However, it may take several days to get your lab test results back. One more thing to keep in mind: this type of test is most appropriate for people who may be showing symptoms of acute HIV and have tested negative with antibody or antibody/antigen tests.
Stages and Progression of HIV
HIV moves through three stages: the acute stage, the clinical latency (or, chronic) stage, and the AIDS (acquired immunodeficiency syndrome) stage.
Acute HIV stage: The first stage of HIV begins two to four weeks after a person acquires the virus. Most people in the acute stage experience flu-like symptoms.
Clinical latency (chronic HIV) stage: The second stage of HIV can begin as soon as one month after exposure to the virus and last between 10 and 15 years. Some people in this stage don't experience symptoms. The virus also continues to multiply at low levels in the immune system if you are not receiving treatment.
AIDS stage: The third and final stage of HIV typically occurs in people who are not receiving treatment. Without treatment, the virus will continue to multiply and weaken the body's immune system. You may experience severe symptoms such as rapid weight loss, pneumonia, and swollen lymph nodes. You are also at an increased risk of developing serious infections and cancers.
Keep in mind: HIV symptoms and how fast (or slow) you move into a different stage of HIV vary from person to person. Your HIV progression can depend on your individual symptoms, whether or not you are on treatment, and your overall health.
Diagnostic Criteria for AIDS
A person has progressed to the AIDS stage when:
The number of CD4 cells in your blood falls below 200 cells per cubic millimeter of blood (200 cells/mm3)
OR, you develop one or more AIDS-defining illnesses (such as lymphoma, herpes, or cervical cancer) regardless of how many CD4 cells you have
HIV is a serious chronic condition that attacks healthy white blood cells (CD4 cells) in your immune system, which can prevent your body's ability to fight off infections. There is no cure for HIV—this is why getting HIV might feel scary. It's OK to be nervous, but it's also important to know that getting a diagnosis early can get you started on treatment sooner.
The only way to know your HIV status is to get an HIV test. An HIV test will use a sample of your blood (from a vein or finger stick), saliva, or urine. There are three types of HIV tests: the antibody test, the antigen/antibody test, and the nucleic acid test (NAT). Depending on the type of test you take, you can receive your results within 30 minutes or up to several days.
Getting an HIV diagnosis can be life-changing and filled with many emotions. Healthcare providers and other care specialists are there to help guide you through a positive HIV test result and the early stages of an HIV diagnosis. Your provider can also help you create a treatment plan that is right for you, which can help you live a long and healthy life with your condition.
HIV.gov. What are HIV and AIDS?
Centers for Disease Control and Prevention. Types of HIV tests.
HIV.gov. HIV testing overview.
UpToDate. Screening and diagnostic testing for HIV infection.
Deeks, S., Overbaugh, J., Phillips, A. et al. HIV infection. Nat Rev Dis Primers. 2015;1(15035). doi:10.1038/nrdp.2015.35
Centers for Disease Control and Prevention. Getting tested.
HIV.gov. Symptoms of HIV.
Signs and Symptoms of HIV
How Is HIV Treated?
3 Types of COVID-19 Tests
What Is Hepatitis C?
How Are Hives Diagnosed?
What is Human Immunodeficiency Virus (HIV)?
How Is Lung Cancer Diagnosed?
HIV Symptoms and Complications in Women
How Long Can You Test Positive for COVID-19?
Omicron Infection Timeline: When Symptoms Start and How Long They Last

redpajama_set_name: RedPajamaCommonCrawl


My passion for skincare flourished this year. Growing up, I had always hated washing my face. It was messy and water got everywhere and it took too long and I didn't know what I was doing. As a teenager, I primarily used a makeup remover from Clinique's Take the Day Off line and a moisturizer from the Moisture Surge Line, plus a facial sunscreen in the summer. I became interested in skincare when I discovered /r/AsianBeauty in early 2015, but that was more because I was going through a lot in my personal life it was an excuse to purchase products. I developed a good routine, but I wasn't ever passionate about skincare beyond making my skin look nicer.
In 2017, I discovered a lot of great skincare Instagram accounts that were fun to follow and didn't take their "routine" too seriously, and I've become much more enthusiastic about skincare throughout the year. This year, I started following people who focused mainly on skincare, like melubbeauty, thewayofthesnail, lathertolashes, goalstogetglowing, and lazyglow. Skincare has become a really fun hobby and I like that I can draw on my knowledge from my undergrad courses in orgo and biochem.
In this post, I'm going to talk about my favourite skincare discoveries of 2017. I won't talk about my all-time favourites – like Cosrx's snail essence, honey overnight mask, and pimple patches – that I discovered prior to this year. For reference, I have combination/oily skin with large pores and some texture. I get hormonal cystic acne along my jawline. I tend to have product reactions in the form of immediate flushing/burning, whitehead breakouts, or cystic acne depending on the ingredient that triggers the reaction. My skin is easily irritated by certain ingredients, but I'm usually okay with ingredients like alcohol and fragrance as long as it doesn't give me a headache. My skin is usually hydrated.
Of all the new products I've tried over the past year, these are the ones that have made the biggest difference in my skin. I have repurchased or plan on repurchasing all five of these.
I can see (and feel) why the @paparecipe Bombée Honey Mask has gotten such rave reviews. It was very hydrating and soothing, and my skin was brighter and more moisturized the next day. The honey smell is fairly strong, but it's not overpowering. It fit nicely and clung to my skin. I wore it for about forty minutes, and then patted the extra essence on my face and décolletage. Why do you do skincare routines? I know that many of you have already answered this on your own accounts, but I'm still curious! I've never had the best skin, yet I was really resistant to skincare in my teens for a myriad of reasons. I got into makeup during my undergrad (kind of as a coping mechanism), and I eventually got into skincare via #rasianbeauty about three years ago. It's really rewarding to see progress in my skin's condition, but that's never been my main motivation. I find skincare routines very therapeutic, and I tend to turn to them as a distraction or comforting ritual.
5. Papa Recipe Bombée Honey Mask – You can read my initial review here. The hype surrounding this mask may have let some people down, but I was definitely impressed. This is one of those masks that makes my skin feel and look like a supermodel (or as close as it gets for me).
4. Healavie Cleansing Oil Gel – I still love this cleanser and I agree with what I noted in my initial impressions. This is the nicest cleanser that I've ever used.
3. Farmacy Honey Potion – Whenever I'm having an adverse skin reaction, I use this wash-off mask and notice immediate effects. It makes my skin feel better and it looks smoother and more even. I usually avoid masks that have a warming sensation, but this one is fairly mild. I won this in a giveaway from @allanaramaa.
2. Stratia Skin Soft Touch AHA – This is 10% mandelic acid. This is my go-to exfoliator whenever my skin is sensitive or irritated. After using this, I notice a decrease redness and an improvement in skin texture the next day. If you're just starting to use AHAs or if you're looking for something more gentle, mandelic acid is a great choice because of it's molecular structure.
What are your favourite skincare discoveries of 2017? Feel free to link your blog or Instagram posts in the comments!
I've been meaning to try the Pixi Glow Tonic, especially because it is more affordable/easier to get than some of the other AHA products. Now I am going to need to try out the Stratia stuff, too!
Nice! Double cleansing has made such a difference for me, too. It's great when a trend is useful.
I really enjoyed this post! Recently I started using a Clarisonic cleansing brush, and I'm enjoying it so far. I've fallen out of love with most of the masks I currently have so I haven't been masking as much as I used to. The products you mentioned sound so darn amazing, I might have to pick some up!


text:
Pharma »
Bristol-Myers Squibb Co
Gilead Sciences Inc
CAR T-cell immunotherapy
Bristol-Myers wins $752 million in U.S. patent case against Gilead
A jury in Los Angeles awarded the damages after finding that Yescarta, a treatment sold by Gilead's Kite Pharma unit, infringed on a patent exclusively licensed by Bristol-Myers' Juno Therapeutics division.Reuters | December 14, 2019, 08:10 IST
By Jan Wolfe
Bristol-Myers Squibb Co on Friday said it won a $752 million jury verdict against Gilead Sciences Inc in a U.S. patent dispute relating to technology for treating cancer.
A jury in Los Angeles awarded the damages after finding that Yescarta, a treatment sold by Gilead's Kite Pharma unit, infringed on a patent exclusively licensed by Bristol-Myers' Juno Therapeutics division.
The patent at issue in the lawsuit, which Juno licenses from the Memorial Sloan Kettering Cancer Center in New York, relates to CAR T-cell immunotherapy for cancer.
CAR-T therapy involves a process of removing T cells from a patient's immune system, engineering them to better identify and attack cancer cells and infusing them back into the patient.
Bristol-Myers said in a statement that it was pleased with the verdict.
Gilead disagreed with the decision.
"We remain steadfast in our opinion that Sloan Kettering's patent is not infringed and is invalid," Gilead said in a statement. "Given that Kite independently developed Yescarta and assumed all of the risk in its discovery and development, we do not believe Sloan Kettering and Juno are entitled to any level of damages."
Gilead said it expected to seek to undo the verdict through post-trial motions and an appeal.
Tags : Pharma, Bristol-Myers Squibb Co, Gilead Sciences Inc, CAR T-cell immunotherapy, patent dispute, cancer treatment
Most Read in Pharma
PM Modi meets chiefs of top pharma companies, asks them to follow ethical marketing practices


text:
BRICS Consider Creating IMF-Alternative As US Loses Credibility -- By Tyler Durden, Zero Hedge
The BRICS countries (Brazil, Russia, India, China and South Africa) have made significant progress in setting up structures that would serve as an alternative to the IMF and the World Bank (which are dominated by the U.S. and the EU), according to RBTH. As WSJ reports, the U.S. would lose its veto power on the International Monetary Fund's executive board under a plan being considered by some emerging economies. The countries are fed up with the United States' failure to ratify a four-year-old deal to restructure the emergency lender. Yet more loss of credibility on the global stage and, as Brazil's FinMin Mantega sums up, "the IMF cannot remain paralyzed and postpone its commitments to reform."
As The Wall Street Journal reports, the U.S. would lose its veto power on the International Monetary Fund's executive board under a plan being considered by some emerging economies.
The countries are fed up with the United States' failure to ratify a four-year-old deal to restructure the emergency lender.
Some members of the IMF's steering committee indicated at a series of weekend meetings their desire to act now, underscoring the growing discontent abroad about the U.S. Congress's delay in approving an international accord to overhaul governance at the fund.
The world's top finance officials gathering here this weekend chastised the U.S. in formal policy statements.
"We are deeply disappointed with the continued delay in progressing the IMF quota and governance reforms," the Group of 20 largest economies said in its communiqué.
And the various countries that would benefit from greater say in the actions of the IMF are not waiting for the US...
"Alternatives to move forward with the reforms must be found whilst the major shareholder does not solve its political problems."


text:
Samantha Mendoza
A graduate student in the Magazine, Newspaper, and Online Journalism program, Samantha is the Lead News Producer for the Newshouse. Born and raised deep in the heart of Texas, she completed her BA in English Writing and Rhetoric and English Literature at St. Edward's University in Austin. She then moved to Chennai, India to teach middle-school English under a Fulbright grant.
Her interest in international human rights and post-conflict reconciliation has taken her across the globe, and she hopes that her career will allow her to contribute to social justice and governmental accountability.
HIV prevention advocates push for change
Syracuse refugees vote in their first presidential election
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Voter registration drive held in an unusual place: a local prison
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Deaf refugees in Syracuse work to overcome unique challenges
Clinton, Trump give voters memorable final debate before Election Day
Covering topics like immigration reform and late-term abortions, Donald Trump...
Fired Whitman dean arrested on prostitution charges
Whitman School dean Kenneth Kavajecz was removed from his position after being...


Enjoy your planning and revel even more with All 0 Promocode.club's great Leimere promotion codes!
Choose a Leimere coupon you would like to use from Promocode.club. Press use Leimere code box, which is located just below. Now your web browser should copy the All 0 Leimere code for you, although it is best to make sure and copy it manually. The https://www.leimere.com/pages/contact web page will open in a new window for you. Go to their Leimere checkout section and find the Promotional Keycode box. Paste your Leimere coupon code there and click apply.


The Bard — Allegory Handcrafted Goods Co.
Classic fountain pen with a screw-off cap. Features a steel, gold-plated, iridium-tipped nib. The Bard comes with one short international black ink cartridge and a standard international piston converter.
The collection that launched the Allegory brand features bold design, deep stories, and a wide variety of options for all tastes and budgets.
50,000 years ago in what is now Northern New Zealand, a major natural event felled huge forests of kauri trees that had been growing for some 2,000 years. This event also created bogs in the area, which protected these giants from the elements. Today these trees are typically found under farmland, where they excavated carefully and the ground is returned to its previous contours.
Before the industrial revolution loggers practiced log driving - where floating logs down-river to a temporary sawmill was the first step in the process of creating lumber. Occasionally logs would sink and become trapped in the silt at the bottom of the river. If enough silt was laid down before rot and erosion set in, the log would be preserved. Today these century-old remnants of pre-industrial America are recovered from the bottom of river beds.


Petsecure is Canada's oldest and largest pet insurance provider.
Petsecure is pet health insurance protection that's designed by Canadian pet owners and recommended by veterinarians. It covers your pet for unexpected accidents or illness, keeping your pet's health and your finances on track.
As pet parents, we believe we can protect our pets from harm. Yet, no matter how much love and care we provide, accidents and illnesses are still beyond our control.
As a Petsecure customer, you'll be reimbursed for up to 80% of the cost of the care and veterinary services. This includes x-rays, hospitalization, surgery and even prescriptions required for any accident or illness.
– Choice of any licensed veterinarian in Canada.
– Covers medical problems and conditions relating to accidents, illness and preventive care.
– Covers dogs and cats of all breeds over 8 weeks old.
– Fast and simple claims.
Petsecure gives you the confidence of knowing that when you need to, you can provide your pet with the very best veterinary treatment and care – you're prepared for the unexpected.
Pet insurance can be very affordable! Your premium will depend on factors like the level of coverage and deductible you choose and the breed and age of your pet at the time you enroll for coverage. Petsecure pet health insurance will help you choose what level of coverage is right for you!
You can choose from different types and levels of coverage to suit your needs and budget.
o when is the best time to sign up for Pet Health Insurance?
It's safest to do so as soon as you bring home that new puppy or kitten. This way you are able to cover congenital and hereditary conditions that have not yet been diagnosed in your puppy or kitten. During the first year of a dog or cat's life is when veterinarians can best discover and treat problems like allergies, heart problems, hip problems, and more.


Hehehe, best looking turkey I have ever seen!
Bless him! He looks in bliss.
Are you cooking in the sun puddle?
I love that face! Is he laughing at the sunbeam? Happy Thanksgiving and I hope your crew gets some turkey.
What a great sun puddle! We miss the sun these days.
He is a very funny looking turkey. Happy day of giving thanks!
Stopping by to wish you and your family a very Happy Thanksgiving!!
Now there's a photo just hoping for a caption.


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ACCEPTED

#### According to
Index Fungorum

#### Published in
null

#### Original name
Macrophoma opuntiicola f. tunae Cif. & Gonz. Frag.

### Remarks
null

redpajama_set_name: RedPajamaGithub


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Microsoft Enterprise Search is Coming to Windows 10
If you spend most of your time buried in apps like Microsoft Word, you might not know about Microsoft's search feature that was first available in preview last September. Enterprise Search isn't a separate app but rather a feature that will be built in to all Office apps, Bing, SharePoint, OneDrive, and Windows 10. Microsoft announced the general availability of Enterprise Search at Build 2019 and is aiming to make it available to all Office 365 customers by the end of May.
An Improved and More Consistent Search Experience
Office 365 users know that the search experience isn't consistent. For example, the OneNote app on Android only searches open notebooks. To search closed notebooks stored in your Office 365 tenant, you need to use Delve or search from the Office.com homepage. Delve doesn't search email, so for that you'd need to open Outlook. And the search box in Windows 10 only searches your OneDrive documents but not files that colleagues have shared with you.
Microsoft Enterprise Search is coming to Windows 10 (Image Credit: Russell Smith)
Looking for your 'stuff' can be frustrating. You need to know which application to search in to get the right results. Microsoft Enterprise Search helps to solve this problem by providing a more consistent search experience across apps and devices by surfacing people, files, and conversations within the context of your work. Conversations include those from Microsoft Teams and Yammer. Enterprise Search is designed to be people-centric, meaning that when you search for a contact, you see their information and any files, events, and conversations that you share.
Enterprise Search doesn't only help you find things. It can also help you to complete tasks. For example, in Teams you can type /files to show recent files or /unread to show all unread messages.
Zero-Typing Experience
As Brad Sams reported for Petri last week, Enterprise Search will provide instant personalized results before you even start typing. For example, it might display people who you regularly share documents with or files that you have been working on.
Other features include the ability to search across the entire organization, not just your own files. Like other search engines, key phrase suggestion, query history, and extensibility via third-party connectors will come later in 2019.
Bing and the Microsoft Graph
Microsoft is combining web and work searches by using the AI technology in Bing and information from the Microsoft Graph. The idea is to enable natural language questions in Bing, regardless of whether you are using the Bing website or browser address bar, to return results that are relevant for you and your organization. Ultimately, Microsoft hopes that you only need to search once to find the information that you need.
Microsoft Enterprise Search in Windows 10
Enterprise Search is rolling out first to Office and Bing. It won't come to Windows 10 until version 20H1 is released next year. But we can expect the same experience and results that are surfaced by Enterprise Search in other places. It's likely that the work Microsoft completed in the Windows 10 May 2019 Update, to separate Cortana and search on the taskbar, is part of the plan for bringing Enterprise Search to Windows.
Office.com versus Bing
You can probably get a good idea of what search will look like in Windows 10 by going to Bing.com and signing in with your Office 365 work or school account. Search for 'me' and you'll see information about your schedule, recent files, and conversations. You can also search for 'my documents' to return just a list of recent files.
If you search for another user in your organization, you'll get similar results showing recent public documents or those that they've shared with you, and conversations. You can also search for 'things' not just people.
Microsoft Enterprise Search is coming to Windows 10 (Image Credit: Microsoft)
What's interesting is that the search experience in Bing differs from Office.com. At the time of writing, Bing surfaces Teams conversations but Office.com doesn't. Maybe I'm missing something, but I was under the impression that the experience should be the same. Email conversations are not surfaced directly in either Bing or Office.com. A list of recent mails and attachments is displayed when you search for a user in your organization and open their details in a separate window. Email conversations with external users don't get the same treatment unless you have set up a contact.
Privacy and Control
Microsoft is promising advanced controls and analytics so that you can get insights to how search is used and change settings to optimize the search experience. For example, you can provide answers to common questions people ask in your organization and target groups, like staff who are onboarding. I couldn't access these settings in my Office 365 tenant but do have the ability to disable Microsoft Search for Bing.
Best for Internal Users and Content
As it stands, Microsoft Enterprise Search works best for internal organizational users and content. I'd like to see improvements when searching for content from external users, whether it is email or shared files. But Microsoft is heading in the right direction and I look forward to seeing how this feature develops as it rolls out to all Office 365 users, apps, and Windows 10 next year.


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Simon Charbit
Location Head
Partner Simon Charbit is excellent. Tremendous responsiveness and always maintains a business-oriented overall view of any engagement.
— Legal 500, 2021
Emailsimon.charbit@dlapiper.com
Simon Charbit is highly experienced in mergers and acquisitions, joint-ventures and private equity transactions in France and abroad.
In addition to his M&A skills, Simon has a strong corporate background advising listed and non-listed companies, and a thorough knowledge of global market practices, most notably in the infrastructure field.
Areas of FocusCorporateMergers and AcquisitionsPrivate Equity
Professional QualificationsAvocat admitted to the Paris BarParis
Advising Eagle Football Holdings LLC in connection with the acquisition of a majority stake in OL Groupe from Holnest, Pathe and IDG Capital.
Advising Sprints Capital in connection with its investment in Back Market.
Advising CoinShares on the acquisition of the Napoleon Group and its Social Trading Platform Expanding into New Consumer Market Segment.
Advising Compagnie Française des Transports Régionaux in connection with the acquisition of the exclusive control of the Holfima transportation group.
Advising Famille C in connection with the acquisition of PAI Skincare by Famille C.
Advising the Asmodee group in connection with acquisition of 55% of Exploding Kittens.
Advising Michelin in connection with the contribution of the 3D business of Fives Machining to Addup.
Advising SPIKA in the context of the acquisition of 60% of the share capital and voting rights of Allopneus from HEVEA.
Advising Cube Infrastructure and Partners Group in connection with the sale of Covage to a consortium composed by Altice, AXA, Allianz and Omers for a consideration in excess of €1 bn.
Advising G.Network, a fast-growing full fibre local access broadband connectivity provider focused on London, in connection with a £1 bn fundraise.
Advising Cube Infrastructure Fund II in connection with its investment in DST group's telecommunications business unit in Portugal.
Advising Idex and Antin Infrastructure in connection with the acquisition of Danpower Baltic.
Advising Cube Infrastructure Fund II with its investment in Veranger Kraftvind the owner of the Raggovida wind farm in Norway.
Advising Cube Infrastructure Fund II in connection with their acquisition of 100% of the share capital of Lacroix Participation et Services, a leader in inter-urban public transportation in the Ile-de-France region.
Advising Cube infrastructure Fund II in connection with its acquisition of Cars Savac.
Advising Limagrain in the acquisition of Unicorn Grain Specialties, a Dutch company specialized in cereal ingredients and legumes for human and animal nutrition, from Nordian Capital.
Advising Idinvest in connection with its investment in the Spanish company 21 Buttons.
Advising the Courtin Clarins Family, owners of the Clarins group, in connection with their investment in various funds.
Assisting Cube Infrastructure Fund II in connection with its acquisition in Norway of a 49% stake in Varanger Kraftvind AS.
Assisting Dassault Systèmes in connection with its VC investment in NuoDB, Inc.
Advising the founders of Disa Technology in connection with its sale to AkzoNobel.
Advising the Diana Group (group Symrise) in connection with the acquisition of the shares of Yummypets.
Advising the founder of Go Fluent in connection with the sale of a minority stake of the Swiss company Go Fluent to Capital Transmission.
University of Pennsylvania law school, LL.M., (2000)
University of René Descartes Paris V, Post Graduate Degree in European business law, (1998)
University of Paris X Nanterre, Master's degree in corporate law, (1996)
IEP de Strasbourg , Bachelor's Degree, (1994)
International Private Equity (IPEM), Cannes, France, September 2022
DLA Piper advises Eagle Football on acquisition of controlling stake in Olympique Lyonnais
DLA Piper advises iubenda on the acquisition of consentmanager
29 November 2022 .3 minute read
(Work, Paris)


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School Computer
Jack Hunt School
A Specialist Language & Sports College
2015 - 2016 News
2010 - 40th Year Celebration
Inform Newsletters
What do Space Travel, Pollution & Holocausts All Have in Common?
What do Space Travel, Pollution & Holocausts All Have in Common?
The answer is Jack Hunt's latest Deep Learning Day! Over the years these days have proved to be immensely successful, they are great fun for everyone and provide lots of imaginative learning opportunities across curriculums.
A car walks into the room, what would you ask it? This was the question that faced Year 7 and 8. They were challenged through a series of tasks, to find out how Jack Hunt School can make a difference to pollution in Peterborough. They were given key skills to use and tasked with producing a presentation at the end of the day to show their proposals.
Each group's final presentation was streamed live to all the other students in their classrooms. Once they had watched them, the voting began using specific criteria to decide which group's proposal was the best. Following the day our school Eco Group, led by Miss Steward are looking to see if they can take any of the proposals further.
Year 9 were set three Science Challenges;
Design A Rocket. They were shown different types of rocket and asked to use their science skills to decide what type and design of rocket would work best.
Design and Build Spyware. Budding Q's from James Bond where given examples of Spyware then asked to design and build their own given materials and a 20 minute deadline!
Finally they got to get their hands dirty, Slime was the next challenge. Students had to make Slime and then investigate what happened if they pulled the slime apart slowly, sharply and quickly, if they rolled it into a ball and dropped it on the bench, hit it hard with their hand or hung it over a ruler to see how far it can go without breaking? Prizes were awarded for the gloopiest slime.
Student feedback was great
"I really liked the Flubber. I wish I could have taken it home and would like to do it again."
"The rocket outside was really loud! I wish we could have done rockets all day".
Lessons from the Past: Journeys of Persecution, was Year 10's focus for the day. They learnt about past and present conflicts that have affected people across the world, especially the aspects of genocide and whether lessons are learnt from the past. The students then heard a testimony from Holocaust Survivor, Zigi Shipper, as part of a visit organised by the Holocaust Educational Trust (HET). Zigi's moving and inspiration speech gave students the opportunity to discuss Jack Hunt's restorative movement.
The testimony was followed by a question and answer session to enable pupils to better understand the nature of the Holocaust and to explore its lessons in more depth. The visit is part of the Holocaust Educational Trust's extensive all year round Outreach Programme, which is available to schools across the UK.
Students were completely bowled over by Zigi,
"Inspirational… made us understand that people should all be treated equally" George Dowds (Yr10) & Simona Bruzinskaite (Yr11)
"It shows us all that equality is needed to make the world a better place" Mollie Swallow, Year 9
"Eye-opening …. made me understand there is a need to hate less in our everyday lives" Hasnaat Mohammed, Year 10
"He made us really appreciate History" Zishan Kayani, Yr9
Georgia Evans, Pledge against Prejudice Leader at Jack Hunt School, said:
"It is a privilege for us to welcome Zigi Shipper to our school and his testimony will remain a powerful reminder of the horrors so many experienced. We are grateful to the Holocaust Educational Trust for co-ordinating the visit and we hope that by hearing Zigi's testimony, it will encourage our students to learn from the lessons of the Holocaust and make a positive difference in their own lives."
At the end of the day, year 10 students held a Newstalk style live debate on 'What are the lessons that we can learn from the past and how can our future be safer or better?' They chose a conflict, then researched and prepared their arguments and presentations for the debates.
The day was finished off with asking them to consider all they had learnt and to make a pledge regarding what lessons they could take forward from their day.
The whole day was a great success. Students and staff alike really enjoyed the day and the school atmosphere was buzzing. We are now looking forward and planning what the next Deep Learning Day will bring.
Sitemap | Contact Us | Back to Top | Copyright © 2019 Jack Hunt School | School Web Design by e4education


First of all – it is fun!
I have already written a post about how to decorate your room with DIY no sew pillows and got some great feedbacks from readers.
This time I rounded up simple, beautiful, no sew curtains tutorials.
Making handmade curtains always seemed to me so difficult and time consuming, probably because I never learned how to use sewing machine (although I hope someday I will…). So when I found a no sew curtains tutorial I was really excited – finally a simple way to make your own curtains! I kept searching and discovered some colorful, inspiring easy to make, on a budget, no sew tutorials for DIY curtains, shades and valances.
I thank all these creative and crafty bloggers for sharing theirs great ideas!
Some great ideas here! I need some new curtains and am a bit of a novice at machine sewing so this is very useful!!


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DPS seeks information on 1995 slaying of Beaumont teacher
June 18, 2020 Updated: June 18, 2020 2:53 p.m.
Mary Catherine Edwards was killed in beaumont in January, 1995. Enterprise file photofile / file
The Texas Department of Public Safety is looking for any information on a 1995 cold case that involved the killing of a Beaumont Independent School District teacher.
The department increased the reward from $3,000 to $6,000 for information that leads to the arrest of anyone responsible for the death of Mary Catherine Edwards, according to a DPS news release.
"Edwards, 31, was a well-loved teacher who lived alone in Beaumont," the release said. "She was last seen on the evening of Friday, Jan. 13, 1995. The following day, she didn't respond to phone calls, so her parents went to her house on Park Meadow Street to check on her. When they arrived, they found Edwards drowned in her bathroom. She had been sexually assaulted and killed."
The release said all leads have been exhausted and Texas Rangers are asking for the public's help.
To be eligible to a reward, tipsters must provide information by calling the Crime Stoppers hotline at 1-800-252-8477 or the Texas Rangers at 1-800-346-3242. People can also go to the Rangers' cold case website. All tips are anonymous.
Anyone who wishes to receive the $6,000 rewards needs to submit their tip before the DPS announces the next cold case in the department's bi-monthly feature.
chris.moore@beaumontenterprise.com
twitter.com/chris_moore09
Reach Chris on
Chris Moore is the Breaking News reporter for the Beaumont Enterprise.


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I Have No Idea What Just Happened: Lady Gaga's 'John Wayne' Video
THURSDAY, FEBRUARY 09, 2017 |
Posted by: Matt Guyotte
You know, for such a weird and out-there song like Lady Gaga's "John Wayne," I'm really glad it got an equally as weird video. But I seriously have no idea what's going on in it. It's wild, and I think that's exactly what Gaga intended, just like the lyric "I crave a real wild man," I think she just wanted a wild video.
Starting off with Gaga riding wildly on the back of a horse with a man presumably named John Wayne, and then having 60's cartoon font outlining the lyrics and introducing the name of the song; it eventually evolves into flames in a suburban neighborhood, Gaga crashing a car, and then shooting somebody with a white stiletto.
I could sit here and try to tell you that it all connects and that there is some deeper meaning behind the whole video. I can't though. You just have to watch it.


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Fair and Balanced? Hardly
Gun Control Film Leaves Four-Hour John Lott Interview on Cutting Room Floor
By AWR Hawkins. May 16th, 2016
Katie Couric's gun control documentary "Under the Gun" was released May 15 without any portion of a four-hour interview conducted with John Lott, Jr.
Lott is president of the Crime Prevention Research Center and a known gun scholar whose seminal work is More Guns, Less Crime.
On May 6, Lott tweeted that he had been "interviewed for 4 hours" for Couric's film and he "bet" that four hours would be reduced to a "select few minutes" of actual screen time. The reduction happened alright. But instead of using those select few minutes, Couric and director Stephanie Soechtig cut Lott's interview altogether. .....
Bias it seems is alive and well. Incredible, if not despicable, that no part of a four hour Lott interview that could have added balance was not used, and this is so typical of the anti-gun approach. The only "facts" that get discussed are those "facts" that are considered convenient to push and skew the agenda.
(A new infographic is now available - "Comparing US State Gun Laws" - this is a useful graphical comparison for easy reference.)


$8.00/adults, $4.00/ages 5-12, under 5 free!
Sponsored by the Sons of the American Legion to benefit the North Country Coalition for Parkinson's Disease & Movement Disorders.
Parkinson's disease is the most widely known movement disorder. The National Institute of Health estimates that Parkinson's Disease affects between 1,000,000 and 1,500,000 individuals in the United States, with 20,000 new patients diagnosed each year.
Once diagnosed, Parkinson's Disease cannot be completely cured. However symptoms of Parkinson's can usually be well treated, allowing patients to lead productive lives for many years. Recently, many new drugs have been made available to further improve treatment. but, as the disease progresses, medical treatment becomes more complicated and may not be as effective. For this reason new approaches have been developed. Surgery can be an option, either to remove a small part of the brain, or to insert a small stimulator that can dramatically improve both the ability to move voluntarily and to reduce abnormal movements.
This North Country Parkinson's website provides information and resource referral for users of the website. Information on products and/or services contained on the website does not imply endorsement or recommendation by the organization.


Prime Location Downtown! This house is located on Church Street just off Franklin Street near Pantana Bob's and Target. You're basically right at Franklin Street and very close to campus. It has 2 bedrooms, 1 bathroom, yard, privacy fence, and off street parking.
OPTIONS: Flexible start date - Start lease in June or August.


On October 19, 2010, Law360 conducted a Q&A with Haynes and Boone Partner Ron Breaux.
Ronald W. Breaux is a partner in Haynes and Boone LLP's Dallas office and chairs the firm's specialized litigation section, where he represents companies and individuals in government investigations and complex commercial litigation matters. He has particular expertise in representing clients in civil and criminal antitrust and securities fraud matters.
To view the interview, please click on the PDF link below.


This week I was invited by Manchester Confidential to sample the menu at 47 King Street West. My husband couldn't make it, so I invited my friend Emma to give me a hand with all that food. Ever the warrior, she accepted, and off we trot.
47 King Street West is nestled just behind House of Fraser, opposite San Carlo. We were welcomed in from the rain, and coats, brollies and other useless waterproof paraphernalia were removed from the theatre of conflict. Inside is a little old fashioned but clean and well finished, and window seats offer a great people watching spot. They market themselves as 'fine dining', but I think 'smart casual' is more appropriate.
For starters I picked the soup of the day, which was honey roasted parsnip, and Emma had the Mediterranean risotto with parmesan. In the interest of the review, we both stole a bot of each others'. The risotto was perfectly cooked and had a generous amount of vegetables. The soup was a good thick texture and I enjoyed the taste, but I fear some would find this too sweet. Parsnips are sweet enough without lots of honey. Saying that, we both loved it. My only criticism of this course was the Chorton artisan bread. It was a little stale and came with packaged butter - only a minor thing but worth noting.
We both fancied the fillet steak medallions, but had them in slightly different ways. I originally ordered the spatchcocked poussin because the pepper sauce was calling, but then when Emma was offered a choice of peppercorn or sunblushed tomato jus, I couldn't resist swapping. They even let me have fat chips with mine rather than pomme puree. I'm done with pomme puree. And micro herbs. And pea foam. Rant over.
We really could not fault these dishes. My steak was rare as requested whilst Emma's was served medium, the sauces were gorgeous and the fat chips were perfectly crispy, just as I had hoped. A very enjoyable main.
As I checked in on Foursquare, someone had recommended the Eton Mess. Couldn't resist. This was a rich pile of ice cream, cream, berries, meringue and coulis. Brilliant. Emma had the Chef's Hot Chocolate Indulgence Pudding with ice cream. This arrived bubbling away! Very rich but equally satisfying.
In summary, 47 King Street West seems to have divided opinion amongst the other bloggers I have spoken to. Yes there are elements which appear a little dated but the execution of our food was good. It's a little expensive (we worked out that our meal would have cost the best part of £100) but I believe there is a cracking deal on at the moment via Manchester Confidential's site - three courses plus Prosecco for £25. Keep an eye open for these.
An enjoyable evening with chatty staff, a great friend and good food. Oh, but they definitely need a bigger coat stand.
Really interesting review thanks and great photos too.


text:
Subject descriptor lookup Advanced Search
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au:"Seok LEE" (2.524)
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Effectiveness and safety of elbasvir/grazoprevir in Korean patients with hepatitis C virus infection: a nationwide real-world study
Eun-Sun JANG; Kyung-Ah KIM; Young-Seok KIM; In-Hee KIM; Byung-Seok LEE; Youn-Jae LEE; Woo-Jin CHUNG; Sook-Hyang JEONG.
The Korean Journal of Internal Medicine ; : S1-S8, 2021.
Article in English | WPRIM | ID: wpr-875506
Background@#/Aim: This study aimed to establish the real-world effectiveness and safety of grazoprevir/elbasvir (EBR/GZR) therapy in South Korea. @*Methods@#A total of 242 patients with chronic hepatitis C virus (HCV) genotype 1 or 4 infection who started EBR/GZR were consecutively enrolled from seven tertiary hospitals. Retrospective analysis of the fractions of patients that achieved sustained virological response (SVR) was performed, and the incidence of adverse events was noted. @*Results@#The mean age of enrolled patients was 59.0 ± 12.6 years and 47.5% were males. Patients with HCV genotype 1b accounted for 93.8% (n = 227), and patients with HCV of unspecified genotype 1 accounted for 5.8% (n = 14). Hypertension was the most common comorbid disease (29.8%) followed by diabetes (22.7%) and chronic kidney disease (CKD, 12.4%). SVR rates of treatment-naïve and treatment-experienced patients were 85.5% (182/213) and 93.1% (27/29), respectively, in the intention-to-treat analyses, whereas in the per-protocol analyses, those were 97.8% (179/183) and 100% (28/28), respectively. Fewer patients with HCV genotype 1 of unspecified subtype achieved SVR (81.8%, n = 11) compared to the patients with SVR infected with genotype 1b (99%, n = 198, p < 0.001). All patients with CKD showed SVR. Itching (12%) and dyspepsia (4.1%) were common adverse events. Of the four patients who discontinued the antiviral therapy, one experienced mild fatigue but neither treatment withdrawal was because of an adverse event. @*Conclusions@#EBR/GZR showed high real-world effectiveness and safety in Korean patients with chronic HCV infection regardless of the previous antiviral treatment, liver cirrhosis, or CKD status.
The clinical, laboratory, and radiologic improvement due to siltuximab treatment in idiopathic multicentric Castleman's disease
Gi-June MIN; Young-Woo JEON; Sung-Soo PARK; Silvia PARK; Seung-Hawn SHIN; Seung-Ah YAHNG; Jae-Ho YOON; Sung-Eun LEE; Byung-Sik CHO; Ki-Seong EOM; Yoo-Jin KIM; Seok LEE; Hee-Je KIM; Chang-Ki MIN; Dong-Wook KIM; Jong-Wook LEE; Seok-Goo CHO.
The Korean Journal of Internal Medicine ; : 424-432, 2021.
Background/Aims@#Idiopathic multicentric Castleman disease (iMCD) comprises approximately 30% of all cases of Castleman disease. It is characterized by constitutional symptoms, enlarged lymph nodes at multiple anatomical sites, and laboratory test abnormalities, which are primarily related to the overproduction of interleukin 6 (IL-6). Siltuximab is a human-mouse chimeric immunoglobulin G1κ monoclonal antibody against human IL-6. In view of the limited treatment options for iMCD, this study aimed to evaluate the efficacy and safety of siltuximab in the management of this condition. @*Methods@#In this real-world retrospective study, we administered siltuximab to 15 patients with iMCD who previously received conventional chemotherapy and/or steroid pulse therapy. The median time to a durable symptomatic response was 22 days (range, 17 to 56). The serum hemoglobin and albumin levels and erythrocyte sedimentation rates significantly normalized after the first 3 months of siltuximab treatment. Lymph node involution, assessed using imaging, was relatively gradual, demonstrating a complete or partial response at 6 months. @*Results@#On an average, the improvements in clinical, laboratory, and radiologic parameters of iMCD in responders were observed after one, three, and eight cycles of siltuximab treatment, respectively. Siltuximab demonstrated a favorable safety profile, and prolonged treatment was well-tolerated. @*Conclusions@#Despite the small sample size of the present study, the results are encouraging and demonstrate the potential of siltuximab as the first-line treatment of iMCD. Further large multicenter studies are needed to evaluate the clinical outcomes and adverse events associated with siltuximab.
Role of tenofovir disoproxil fumarate in prevention of perinatal transmission of hepatitis B virus from mother to child: a systematic review and metaanalysis
Young-Sun LEE; Ha-Seok LEE; Ji-Hoon KIM; Sung-Won CHANG; Myung-Han HYUN; Haein BAK; Sehwa KIM; Min-jin LEE; Chan-Uk LEE; Young-Kul JUNG; Yeon-Seok SEO; Hyung-Joon YIM; Jong-Eun YEON; Soon-Ho UM; Kwan-Soo BYUN.
The Korean Journal of Internal Medicine ; : 76-85, 2021.
Background/Aims@#To prevent the perinatal transmission of hepatitis B virus (HBV) from mother to child, administration of an antiviral agent during pregnancy has been attempted in women who are either hepatitis B e antigen positive or have a high viral load. In this systematic review and meta-analysis with randomized controlled trials, we analyzed the efficacy and safety of tenofovir disoproxil fumarate (TDF) in preventing the perinatal transmission of HBV in pregnant women who have high HBV DNA titers. @*Methods@#Multiple comprehensive databases (PubMed, EMBASE, and Cochrane databases) were searched for studies evaluating the efficacy of TDF for the prevention of perinatal transmission of HBV. @*Results@#Two studies (one open label study and one double blind study) were included and analyzed. Intention-to-treat analysis (527 pregnancies) showed that the preventive effect of TDF was not significant (odds ratio [OR], 0.53; 95% confidence interval[CI], 0.13 to 2.17; p = 0.38, I2 = 81%). However, the per-protocol analysis showed that TDF significantly reduced perinatal transmission (OR, 0.10; 95% CI, 0.01 to 0.77; p = 0.03, I2 = 0%). There was no significant difference between the TDF group and the control group with respect to maternal and fetal safety outcomes. @*Conclusions@#In pregnant women who have high HBV DNA titers, TDF can reduce the perinatal transmission from mother to child without significant adverse events.
Evidence-based treatment of osteoporotic vertebral compression fracture
Subum LEE; Dae-Chul CHO; Kyong-Tae KIM; Young-Seok LEE.
Journal of the Korean Medical Association ; : 200-207, 2021.
Article in Korean | WPRIM | ID: wpr-875025
The prevalence and medical costs of osteoporotic vertebral compression fractures (OVCFs) are on the rise. However, a concrete evidence-based treatment guideline has not yet been established. Despite that numerous randomized controlled trials (RCTs) were performed, the study design and outcome measurement were heterogeneous, and the results were not unified. The purpose of this review is to compare the results of high level-evidence studies to provide a background for evidence-based OVCF treatment. Many reports showed that vertebroplasty has better clinical outcomes than non-surgical treatment for OVCF, but the results of three double-blinded RCTs with the highest level of evidence did not show a significant difference between vertebroplasty and sham procedure. Whether undergoing surgical or non-surgical treatment, OVCF patient management should be started by managing osteoporosis first. Meanwhile, in the results of RCTs related to the comparison of conservative treatment modalities, the benefit of braces and a specific analgesic prescription protocol was also unclear. The presented results of each clinical trial were generally inconsistent and may not be appropriate in all situations. Any decision by clinicians to apply this evidence must be made considering individual patients and available resources. At present, controversy remains about the best treatment modality for OVCF. Large, multicenter, placebo/sham-controlled trials are needed to address this gap and establish strong evidence-based guidelines.
Process of Obtaining Social Consensus and 3-Year Functional Outcomes of the First Hand Allotransplantation in Korea
Sang-Hyun WOO; Young-Woo KIM; Ho-Jun CHEON; SungHo JANG; Jun-Young DO; Joon-Hyuk CHOI; Dong-Ho KANG; Hyun-Jae NAM; Myung-Jae YOO; Young-Seok LEE; Jin-Hee CHOI.
Journal of Korean Medical Science ; : e6-2021.
Background@#On February 2, 2017, the surgical team of ten board-certified hand specialists of W Hospital in Korea successfully performed the nation's first hand transplantation at Yeungnam University Medical Center (YUMC). This paper reports on the legal, financial, and cultural hurdles that were overcome to open the way for hand transplantation and its functional outcomes at 36 months after the operation. @*Methods@#W Hospital formed a memorandum of understanding with Daegu city and YUMC to comply with government regulations regarding hand transplantation. Campaigns were initiated in the media to increase public awareness and understanding. With the city's financial and legal support and the university's medical cooperation, a surgical team performed a left distal forearm hand transplantation from a brain-dead 48-year-old man to a 35-year-old left-handed man. @*Results@#With this successful allotransplantation, the Korean Act on Organ Transplantation has now been amended to include hand transplantation. Korean national health insurance has also begun covering hand transplantation. Functional outcome at 36 months after the operation showed satisfactory progress in both motor and sensory functions. The disabilities of the arm, shoulder, and hand score were 23. The final Hand Transplantation Score was 90 points. Functional brain magnetic resonance imaging shows significant cortical reorganization of the corticospinal tract, and reinnervation of intrinsic muscle is observed. @*Conclusions@#Hand transplantation at the distal forearm shows very satisfactory outcomes in functional, aesthetical, and psychological aspects. Legal and financial barriers against hand transplantation have long been the most burdensome issues. Despite this momentous success, there have been no other clinical applications of vascularized composite allotransplantation due to the limited acceptance by Korean doctors and people. Further public education campaigns for vascularized composite allotransplantation are needed to increase awareness and acceptance.
The Safety of Radiofrequency Ablation Using a Novel TemperatureControlled Probe for the Treatment of Residual Intraductal Lesions after Endoscopic Papillectomy
Young-Hoon CHOI; Seung-Bae YOON; Jae-Hyuck CHANG; In-Seok LEE.
Gut and Liver ; : 307-314, 2021.
Background/Aims@#Treatment of residual intraductal lesions after endoscopic papillectomy for ampullary adenomas is relatively difficult. Few studies have been conducted using intraductal radiofrequency ablation (RFA) in the treatment of such lesions, and no study has aimed to reduce the side effects of excessive heat caused by RFA. Recently, a temperature-controlled RFA probe was developed to avoid excessive heat. This study aimed to investigate the safety of this new RFA probe in the treatment of intraductal lesions of ampullary adenoma. @*Methods@#Patients who received RFA for residual intraductal lesions after endoscopic papillectomy between November 2017 and June 2019 were retrospectively reviewed. A novel temperature-controlled probe (ELRA) was used for intraductal RFA, and clinical data including adverse events were collected. @*Results@#Ten patients were included in this study. Intraductal adenomas showed low-grade dysplasia in eight patients and high-grade dysplasia in two patients. The median diameter of intraductal adenomas was 9 mm (range, 5 to 10 mm) in the common bile duct and 5 mm (range, 4 to 11 mm) in the pancreatic duct. Adverse events occurred in three patients (30.0%), of which two were mild pancreatitis and one was asymptomatic biliary stricture. Over a median follow-up period of 253 days, only one patient underwent additional surgery, as the remainder showed no adenomatous lesions on follow-up biopsies. @*Conclusions@#The new temperature-controlled RFA probe can be used with acceptable safety for the treatment of residual intraductal lesions after endoscopic papillectomy. Further evaluation through future prospective studies is needed.
Expression of Chemokine CCL28 in Ulcerative Colitis Patients
Dong-Seok LEE; Kook-Lae LEE; Ji-Bong JEONG; Sue SHIN; Su-Hwan KIM; Ji-Won KIM.
Gut and Liver ; : 70-76, 2021.
Background/Aims@#Ulcerative colitis (UC) is an inflammatory bowel disease for which new serological markers are required. The purpose of this study was to assess the role of the mucosaassociated epithelial chemokine CCL28 in UC. @*Methods@#The study included 50 patients; of these, 25 were patients with UC, and 25 were healthy controls. The levels of serum CCL28 were analyzed using enzyme-linked immunosorbent assay. CCL28 expression was analyzed by immunohistochemistry (IHC) in 15 representative colon tissues biopsied based on disease activity (UC patients with severe activity, five samples;UC patients with mild activity, five samples; healthy controls, five samples). @*Results@#The serum CCL28 levels were remarkably higher (p<0.05) in patients with UC (median, 235.7 pg/mL; IQR, 63.8 to 117.2 pg/mL) than in healthy controls (median, 48.9, pg/mL; IQR, 35.9 to 42.0 pg/mL). However, there was no significant difference in serum CCL28 according to disease extent or activity. In contrast, IHC analysis revealed a significant difference in CCL28 consistent with disease status, disease extent, and disease activity. @*Conclusions@#CCL28 could be useful for diagnosing UC. However, further validations of CCL28 on disease activity and severity are needed.
Strategy for salvaging infected breast implants: lessons from the recovery of seven consecutive patients
Hyeonjung YEO; Dongkyu LEE; Jin-Soo KIM; Pil-Seon EO; Dong-Kyu KIM; Joon-Seok LEE; Ki-Tae KWON; Jeeyeon LEE; Ho-Yong PARK; Jung-Dug YANG.
Archives of Plastic Surgery ; : 165-174, 2021.
Background@#In recent years, implant-based breast reconstruction has been performed because of its simplicity, short operation time, and rapid recovery of patients. Several studies have reported treatment methods for implant surgery-related infection, which is a serious complication. The aim of this study was to introduce our strategy for salvaging infected implants and to evaluate its effectiveness. @*Methods@#The authors performed a retrospective study of 145 cases from 132 patients who underwent implant-based breast reconstruction from January 2012 to December 2018. Empirical antibiotics were immediately administered to patients with suspected infections. The patients then underwent salvage treatment including appropriate antibiotics, ultrasonography-guided aspiration, debridement, antibiotic lavage, and implant exchange through a multidisciplinary approach. Patient demographics, operative data, duration until drain removal, adjuvant treatment, and complications were analyzed. @*Results@#The total infection rate was 5.5% (8/145). A longer indwelling catheter period and adjuvant treatment were significantly associated with infection. The salvage treatment showed a success rate of 87.5% (7/8). Seven patients who received early aggressive salvage treatment recovered from infection. One patient with methicillin-resistant Staphylococcus aureus, who received salvage treatment 11 days after symptom onset, did not respond to drainage and antibiotic treatment. That patient subsequently underwent explantation. @*Conclusions@#In implant-based breast reconstruction, prevention of infection is of the utmost importance. However, if an infection is suspected, proactive empirical antibiotic therapy and collaboration with the necessary departments are required. Through a multidisciplinary approach and proactive early management, swift and appropriate salvage should be performed.
Superficial angiomyxoma of the posterior neck
Young-Joong HWANG; Hong-Won LEE; Il-Seok LEE; Sung-Gyun JUNG; Hye-Kyung LEE.
Archives of Craniofacial Surgery ; : 62-65, 2021.
Superficial angiomyxoma (SA) is a rare, benign, cutaneous soft tissue tumor. It is composed of myxoid matrix and blood vessels. Herein, we report a case of a solitary SA on the posterior neck of a 6-year-old boy. An analysis of the biopsied specimen showed a prominent myxoid stroma with thin-walled, branching blood vessels, revealing the presence of an SA. SA especially that originating in the posterior neck, is rarely seen and should be considered as a differential diagnosis for a solitary mass in the posterior neck.
Paraplegia after transforaminal epidural steroid injection in a patient with severe lumbar disc herniation - A case report -
Seok-Ho JEON; Won JANG; Sun-Hee KIM; Yong-Hyun CHO; Hyun-Seok LEE; Hyun-Cheol KO.
Anesthesia and Pain Medicine ; : 96-102, 2021.
Background@#Transforaminal epidural steroid injection (TFESI) is a conservative treatment for patients with lumbar disc herniation (LDH). However, there are reports of various complications that can occur after TFESI; among these, paraplegia is a serious complication. Case: A 70-year-old woman who was unable to lie supine due to low back pain exacerbation during back extension underwent TFESI. After injection, there was pain relief and the patient was able to lie supine; however, paraplegia developed immediately. Magnetic resonance imaging confirmed cauda equina syndrome (CES) due to nerve compression from L1–2 LDH. We determined that the patient's LDH was already severe enough to be considered CES and that the TFESI procedure performed without an accurate understanding of the patient's condition aggravated the disease. @*Conclusions@#It is important to accurately determine the cause of pain and disease state of a patient to establish a correct treatment plan before TFESI is performed.
Associations of Dietary Intake with Cardiovascular Disease, Blood Pressure, and Lipid Profile in the Korean Population: a Systematic Review and Meta-Analysis
Jeongseon KIM; Tung HOANG; So-Young BU; Ji-Myung KIM; Jeong-Hwa CHOI; Eunju PARK; Seung-Min LEE; Eunmi PARK; Ji-Yeon MIN; In-Seok LEE; So-Young YOUN.
Journal of Lipid and Atherosclerosis ; : 205-229, 2020.
OBJECTIVE: Previous studies have separately reported the contributions of dietary factors to the risk of cardiovascular disease (CVD) and its markers, including blood pressure (BP) and lipid profile. This study systematically reviewed the current evidence on this issue in the Korean population.METHODS: Sixty-two studies from PubMed and Embase were included in this meta-analysis. We performed a random-effects model to analyze pooled odds ratios (ORs) and hazard ratios (HRs) and their 95% confidence intervals (CIs) for the consumption of 14 food items, three macro- and eight micro-nutrients, two dietary patterns, and three dietary indices.RESULTS: An analysis of pooled effect sizes from at least four individual study populations showed significant associations between coffee consumption and CVD (OR/HR, 0.71; 95% CI, 0.52–0.97) and elevated/high triglycerides (TG) (OR, 0.84; 95% CI, 0.78–0.90), sugar-sweetened beverage intake and elevated BP (OR/HR, 1.20; 95% CI, 1.09–1.33), and milk and dairy intake and elevated/high TG and elevated high-density lipoprotein cholesterol (HDL-C) (OR/HR, 0.82; 95% CI, 0.76–0.89 for both). Carbohydrate consumption and the low-carbohydrate-diet score were consistently related to an approximately 25% risk reduction for elevated TG and HDL-C. A lower risk of elevated total cholesterol, but not low-density lipoprotein, was additionally observed for those with a higher low-carbohydrate-diet score. A healthy dietary pattern was only associated with a reduced risk of elevated TG in the Korea National Cancer Screenee Cohort (OR, 0.81; 95% CI, 0.67–0.98).CONCLUSION: This study showed that milk and dairy and coffee had protective effects for CVD and its risk factors, such as BP and lipid profile, while sugar-sweetened beverages exerted harmful effects.
Asian Continental Ancestry Group , Beverages , Blood Pressure , Cardiovascular Diseases , Cholesterol , Coffee , Cohort Studies , Dyslipidemias , Humans , Hypertension , Korea , Lipoproteins , Milk , Odds Ratio , Risk Factors , Risk Reduction Behavior , Triglycerides
Analysis of Prognosis according to Type of Health Insurance in Five Major Gastrointestinal Cancer Patients in Public Hospitals: Single-institution Retrospective Study / 대한소화기학회지
Dong-Seok LEE; Jaekyung LEE; Ji-Won KIM; Kook-Lae LEE; Byeong-Gwan KIM; Su-Hwan KIM; Yong-Jin JUNG.
The Korean Journal of Gastroenterology ; : 17-22, 2020.
BACKGROUND/AIMS: Public hospitals were established to provide high quality medical services to low socioeconomic status patients. This study examined the effects of public hospitals on the treatment and prognosis of patients with five-major gastrointestinal (GI) cancers (stomach cancer, colon cancer, liver cancer, bile duct cancer, and pancreatic cancer).METHODS: Among the 1,268 patients treated at Seoul National University Boramae Medical Center from January 2010 to December 2017, 164 (13%) were in the medicare group. The data were analyzed to identify and compare the clinical manifestations, treatment modality, and clinical outcomes between the groups.RESULTS: No statistically significant differences in the clinical data (age, sex), treatment method, and five-year survival rate were observed between the health insurance group and medicare group in the five major GI cancer patients. On the other hand, some medicare group patients tended more comorbidities and fewer treatment options than health insurance patients.CONCLUSIONS: Public hospitals have a positive effect on the treatment and prognosis in medicare group patients with the five-major GI cancers.
Bile Duct Neoplasms , Colonic Neoplasms , Comorbidity , Gastrointestinal Neoplasms , Hand , Hospitals, Public , Humans , Insurance Coverage , Insurance, Health , Liver Neoplasms , Medicare , Methods , Prognosis , Retrospective Studies , Seoul , Social Class , Survival Rate
MR Imaging of Radiation-Induced Lumbosacral Plexopathy, as a Rare Complication of Concomitant Chemo-Radiation for Cervical Cancer
Eun-Taeg HWANG; Hye-Min SON; Jin-Young KIM; Sung-Min MOON; Ho-Seok LEE.
Investigative Magnetic Resonance Imaging ; : 46-50, 2020.
Article | WPRIM | ID: wpr-835530
Radiation-induced lumbosacral plexopathy (RILSP) is an uncommon complication of pelvic radiotherapy that can result in different degrees of sensory and motor deficits.An age 59 female with cervical cancer, who had received combined chemotherapy and radiation therapy two years before, presented with bilaterally symmetric lowerextremity weakness and tingling sensation. The magnetic resonance imaging showed diffuse T2 bright signal intensity and mild enhancement along the bilateral lumbosacral plexus with no space-occupying masses. RILSP was diagnosed after the exclusion of malignant and inflammatory plexopathies.
Effects of Cryopreservation and Thawing on Single-Cell Transcriptomes of Human T Cells
Jeong-Seok LEE; Kijong YI; Young-Seok JU; Eui-Cheol SHIN.
Immune Network ; : e34-2020.
Cryopreservation and thawing of PBMCs are inevitable processes in expanding the scale of experiments in human immunology. Here, we carried out a fundamental study to investigate the detailed effects of PBMC cryopreservation and thawing on transcriptomes. We sorted Tregs from fresh and cryopreserved/thawed PBMCs from an identical donor and performed single-cell RNA-sequencing (scRNA-seq). We found that the cryopreservation and thawing process minimally affects the key molecular features of Tregs, including FOXP3. However, the cryopreserved and thawed sample had a specific cluster with up-regulation of genes for heat shock proteins. Caution may be warranted in interpreting the character of any cluster of cells with heat shock-related properties when cryopreserved and thawed samples are used for scRNA-seq.
Prognostic utility of N-terminal pro-B-type natriuretic peptide in adult and elderly patients with community acquired pneumonia
Jeong-Min CHOI; Ki-Young JEONG; Han-Sung CHOI; Hoon-Pyo HONG; Jong-Seok LEE; Seok-Hun KO.
Journal of the Korean Society of Emergency Medicine ; : 380-390, 2020.
Objective@#N-terminal pro-B-type natriuretic peptide (NT-proBNP) is suggested as a prognostic biomarker for communityacquired pneumonia (CAP). However, its predictive value for an individual adult and elderly CAP patients has not been fully investigated. @*Methods@#Patients with CAP aged 18 years and older, who visited the emergency department (ED) from March 1, 2016 to March 31, 2019, were included in this study. Patients were divided into the adult group and the elderly group (age ≥70 years). Data was collected from the ED-based registry, and medical charts were retrospectively reviewed. The registry data included sociodemographic and past medical characteristics, as well as laboratory findings including NT-proBNP and C-reactive protein (CRP), Pneumonia Severity Index (PSI), and CURB65 (confusion, urea, respiratory rate, blood pressure, and aged 65 or more). The independent potential of NT-proBNP to predict mortality was assessed in both groups using multivariable logistic regression, and its predictive ability was evaluated in terms of performance (using areas under the curve [AUCs]) and goodness-of-fit (using the Bayesian information criterion [BIC]). @*Results@#Totally, 325 CAP patients were evaluated, of which 208 (64%) belonged to the elderly group. NT-proBNP was identified as an independent predictor of CAP mortality in elderly patients, but not in adult patients. Moreover, AUC of the NT-proBNP for mortality was comparable to AUC of the PSI, but was higher than that of the CURB65, in elderly CAP patients. Similarly, the NT-proBNP had a better overall fit (lower BIC value) compared to the CURB65, for mortality. Additionally, both AUC and overall fit of the NT-proBNP for mortality were significantly superior to values obtained for CRP. @*Conclusion@#For elderly CAP patients in the ED, the NT-proBNP is an independent and useful predictor of mortality.
Anti-LGI-1 Encephalitis with Worsening Symptoms Associated with Hyponatremia
Min-Joo KIM; Jung-Seok LEE.
Journal of the Korean Neurological Association ; : 310-313, 2020.
Anti-leucine-rich glioma-inactivated 1 (LGI-1) encephalitis is clinically characterized by subacute cognitive decline and frequent seizures including fasciobrachial dystonic seizures. A 67-year-old man visited the emergency department due to the recurrent episodes of seizures of 4 days duration. At the time of the visit, he showed hyponatremia at Na 121 mg/dL. His symptoms were relieved by 3% sodium chloride and water restriction. Here we report a case of anti-LGI-1 encephalitis with worsening symptoms associated with hyponatremia.
Oculomotor Nerve Palsy that Developed after Endovascular Treatment in an Acute Stroke Patient with a Dissecting Occlusion of the Extracranial Internal Carotid Artery
Joong-Goo KIM; Chul-Hoo KANG; Jay-Chol CHOI; Jung-Hwan OH; Jung-Seok LEE; Sa-Yoon KANG; Sook-Keun SONG; Ji-Hoon KANG.
Oculomotor nerve palsy is underrecognized clinical manifestation of extracranial internal carotid artery (ICA) dissection. Herein we report a case of complete oculomotor nerve palsy following endovascular revascularization, which developed in a patient with acute stroke due to extracranial ICA dissecting occlusion. We also discuss about the development mechanism of oculomotor nerve palsy, considering the vascular anatomy and the possibility of periprocedural complications during endovascular treatment.
The Practice Guideline for Vaccinating Korean Patients with Autoimmune Inflammatory Rheumatic Disease
Yu-Bin SEO; Su-Jin MOON; Chan-Hong JEON; Joon-Young SONG; Yoon-Kyoung SUNG; Su-Jin JEONG; Ki-Tae KWON; Eu-Suk KIM; Jae-Hoon KIM; Hyoun-Ah KIM; Dong-Jin PARK; Sung-Hoon PARK; Jin-Kyun PARK; Joong-Kyong AHN; Ji-Seon OH; Jae-Won YUN; Joo-Hyun LEE; Hee-Young LEE; Min-Joo CHOI; Won-Suk CHOI; Young-Hwa CHOI; Jung-Hyun CHOI; Jung-Yeon HEO; Hee-Jin CHEONG; Shin-Seok LEE.
Infection and Chemotherapy ; : 252-280, 2020.
To develop a clinical practice guideline for vaccination in patients with autoimmune inflammatory rheumatic disease (AIIRD), the Korean College of Rheumatology and theKorean Society of Infectious Diseases developed a clinical practice guideline according to the clinical practice guideline development manual. Since vaccination is unlikely to cause AIIRD or worsen disease activities, required vaccinations are recommended. Once patients are diagnosed with AIIRD, treatment strategies should be established and, at the same time, monitor their vaccination history. It is recommended to administer vaccines when the disease enters the stabilized stage. Administering live attenuated vaccines in patients with AIIRD who are taking immunosuppressants should be avoided. Vaccination should be considered in patients with AIIRD, prior to initiating immunosuppressants. It is recommended to administer influenza, Streptococcus pneumoniae, hepatitis A, hepatitis B, herpes zoster, measlesmumps- rubella virus, human papillomavirus, and tetanus-diphtheria-pertussis vaccines in patients with AIIRD; such patients who planned to travel are generally recommended to be vaccinated at the recommended vaccine level of healthy adults. Those who live in a household with patients with AIIRD and their caregivers should also be vaccinated at levels that are generally recommended for healthy adults.
Long-term mortality of patients discharged from the hospital after successful critical care in the ICU in Korea: a retrospective observational study in a single tertiary care teaching hospital / 대한마취과학회지
Se-Hee NA; Cheung-Soo SHIN; Gwan-Ho KIM; Jae-Hoon KIM; Jong-Seok LEE.
Korean Journal of Anesthesiology ; : 129-136, 2020.
Background@#The long-term outcomes of patients discharged from the hospital after successful care in intensive care unit (ICU) are not briskly evaluated in Korea. The aim of this study was to assess long-term mortality of patients treated in the ICU and discharged alive from the hospital and to identify predictive factors of mortality. @*Methods@#In 3,679 adult patients discharged alive from the hospital after ICU care between 2006 and 2011, the 1-year mortality rate (primary outcome measure) was investigated. Various factors were entered into multivariate analysis to identify independent factors of 1-year mortality, including sex, age, severity of illness (APACHE II score), mechanical ventilation, malignancy, readmission, type of admission (emergency, elective surgery, and medical), and diagnostic category (trauma and non-trauma). @*Results@#The 1-year mortality rate was 13.4%. Risk factors that were associated with 1-year mortality included age (hazard ratio: 1.03 [95% CI, 1.02–1.04], P < 0.001), APACHE II score (1.03 [1.01–1.04], P < 0.001), mechanical ventilation (1.96 [1.60–2.41], P < 0.001), malignancy (2.31 [1.82–2.94], P < 0.001), readmission (1.65 [1.31–2.07], P < 0.001), emergency surgery (1.66 [1.18–2.34], P = 0.003), ICU admission due to medical causes (4.66 [3.68–5.91], P < 0.001), and non-traumatic diagnostic category (6.04 [1.50–24.38], P = 0.012). @*Conclusions@#The 1-year mortality rate was 13.4%. Old age, high APACHE II score, mechanical ventilation, malignancy, readmission, emergency surgery, ICU admission due to medical causes, and non-traumatic diagnostic category except metabolic/endocrinologic category were associated with 1-year mortality.
Effect of BMS-470539 on lipopolysaccharide-induced neutrophil activation / 대한마취과학회지
Seongheon LEE; Wan JU; Tran-Duc TIN; Joungmin KIM; Jeong-Seok LEE; Cheon-Hee PARK; Sang-Hyun KWAK.
Background@#BMS-470539, a recently introduced selective agonist of the melanocortin 1 receptor, is known to have anti-inflammatory properties. In this study, we investigated the effects of BMS-470539 on lipopolysaccharide (LPS)-induced inflammatory responses and delayed apoptosis with its signaling pathways in human neutrophils. @*Methods@#Isolated human neutrophils were incubated with various concentrations of BMS-470539 (1, 10, and 100 µM) in the presence or absence of LPS (100 ng/ml), and the expression of pro-inflammatory cytokines, such as tumor necrosis factor alpha, interleukin (IL)-6, and IL-1β, were assessed. The effects of BMS-470539 on the expression of mitogen-activated protein kinases (MAPKs), such as p38, extracellular-signal-regulated kinase 1/2, and c-Jun N-terminal kinase, and the expression of nuclear factor kappa B (NF-κB) in LPS-stimulated human neutrophils, were evaluated by enzyme-linked immunosorbent assay. Neutrophil apoptosis was also measured by fluorescence-activated cell sorting (annexin V/propidium iodide) in LPS-stimulated neutrophils under treatment with BMS-470539. @*Results@#BMS-470539 attenuated LPS-induced expression of pro-inflammatory cytokines, and phosphorylation of MAPKs and NF-κB. LPS stimulation reduced neutrophil apoptosis compared to the controls; however, BMS-470539 significantly inhibited the reduction of neutrophil apoptosis. @*Conclusions@#BMS-470539 can suppress the inflammatory responses of LPS-stimulated neutrophils by inhibition of MAPK pathways or NF-κB pathway, and it can also inhibit LPS-delayed neutrophil apoptosis.
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Carriazo es la capital del municipio de Ribamontán al Mar (Cantabria, España). En 2008 la localidad contaba con 197 habitantes (INE) y 6,041 km². El pueblo está ubicado junto al arroyo río Herrer, a los pies de una serie de lomas con las alturas de Corona de 178 , Funegra de 187  y Calobro de 188 .

El pueblo está a una distancia de 34,5 kilómetros de Santander y se halla a 50 metros sobre el nivel del mar. En esta localidad nacieron el maestro de cantería Pedro de Aguilera (siglo XVI) y Gregorio de la Roza (1643–1708), el empresario Felipe Roque de la Portilla (1776–1841) y el veterinario Dimas Asón Quintana (1920–2006).

Carriazo celebra San Roque y San Roquín el 16 y 17 de agosto, respectivamente, y San Martín el 11 de noviembre.

Localidades de Ribamontán al Mar
Capitales municipales de Cantabria

redpajama_set_name: RedPajamaWikipedia