text:
Q: Populate CheckboxList Based on URL Parameters I am trying to retrieve value from URL parameters and populate the value to a checkboxlist. Next step,  select the checkbox value, update the URL parameter. My sandbox  URL is https://oh2p2e.csb.app/?checkedCampusItems=A,B. Right now, it only works with one value in the URL. What is my problem? How do I synchronize the URL parameter value when clicking the checkboxlist? Many thanks.

A: https://oh2p2e.csb.app/?checkedCampusItems=A,B
The A and B should be selected.
That means you should grab the 'checkedCampusItems', that will return you a string 'A,B'.
For example:
// valuesToCheck is the array that contains
// the values from the url parameter
const valuesToCheck = checkedCampusItems.split(,);

// Now you can see which one should be checked.
// The three checkboxes will be rendered but
// the ones you want to will be checked.
<input type="checkbox" checked={valuesToCheck.includes('A')} onCheck={() => history.push(`/checkedCampusItems?=${currentValue},A`)} />

<input type="checkbox" checked={valuesToCheck.includes('B')} onCheck={() => history.push(`/checkedCampusItems?=${currentValue},A`)} />

<input type="checkbox" checked={valuesToCheck.includes('C')} onCheck={() => history.push(`/checkedCampusItems?=${currentValue},A`)} />
)

This is not the exact code, but you get the main point.

A: You are getting TypeError this.history.push is not a function beacause you can't use this reference in functional component.
Second thing, useHistory() is now deprecated, you can use useNavigation() insted.
To summarize, first add this line:

*

*Import {useNavigation} from "react-router-dom";

*Then, change input element like this :
          <input
               type="checkbox"
               id={`custom-checkbox-${index}`}
               name={name}
               value={name}
               checked={checkedState[index]}
               onChange={() => handleOnChange(value, index)}
             />

*Change handleOnChange function like this:
const handleOnChange = (value, position) => {
const updatedCheckedState = checkedState.map((item, index) =>
index === position ? !item : item
);
setCheckedState(updatedCheckedState);
// update URL params
console.log(searchParams);
navigation(/?checkedCampusItems=${value});
};
Here is sandbox : https://codesandbox.io/s/checkboxlist-forked-c1lt1x?file=/src/App.js:1513-1824


Honesty, Proactive Communication, Quality Craftsmanship, Passion For What We Do................Hawksley's 30 year formula for success.
Hawksley Masonry has been in business over 30 years and is owned and operated by Don Hawksley. Don and his highly trained team specialize in Brick Veneer, Stucco Stone, Natural Stone, and Block and Interlocking Pavers. Our master Masons have a minimum of 5 years up to twenty years of experience. That experience allows us to take on and successfully manage masonry designs for both commercial and residential projects.
Our territory includes Marin, Alameda, Napa, San Mateo, Solano, Sonoma, Santa Clara, Contra Costa, and San Francisco Counties.
So if you need a quote for path's or patio's, driveways, CMU, outdoor kitchen and grills, outdoor fireplaces and pits, retaining walls and rock work, posts, fences, columns, gates and mailboxes please give us a call at (925) 754-5641 or email us at estimating@hawksleymasonry.com.


NO PURCHASE, ONLINE SERVICE SUBSCRIPTION OR PAYMENT OF ANY KIND NECESSARY TO ENTER OR WIN.
PURCHASE WILL NOT IMPROVE AN ENTRY'S CHANCE OF WINNING.
The Reminisce Extra Hattie's Hatpin Sweepstakes (the "Sweepstakes") is sponsored by RDA Enthusiast Brands, LLC ("Sponsor"). Sweepstakes begins April 17, 2019 and ends June 18, 2019 (the "Sweepstakes Deadline Date").
ELIGIBILITY: Sweepstakes open to persons age 18 and older who are legal residents of the United States, its territories and possessions, or of Canada (excluding the Province of Quebec). Employees, officers and directors of Sponsor, its affiliated or subsidiary companies, judging agents and promotion partners, and immediate family members and members of the same household (whether related or not) of such persons, are not eligible. Sweepstakes is void in the Province of Quebec and where prohibited by law or otherwise regulated. All applicable federal, state/provincial and local laws and regulations apply.
HOW TO ENTER: You can enter this Sweepstakes via the Internet. Please go to reminisce.com/hatpin and follow the online entry instructions. To enter successfully you must fill in the online entry form including your full name, address, city, state/province, zip/postal code, telephone number, email address (if you have one) along with the magazine page numbers where you found Hattie's Hatpins. You will find two hatpins in each issue of Reminisce Extra. To be eligible all entries must be received by 11:59 p.m. (Eastern Time) on the Sweepstakes Deadline Date. Only one entry per person is permitted. All entries become the property of the Sponsor and will not be returned. If multiple entries are received, only the first entry will be included and later entries will be disqualified. Each entry has an equal chance to win. In the event of any dispute regarding the identity of an entrant for any online entry, the authorized account holder of the email address used for the entry at the time of entry will be deemed the entrant. "Authorized account holder" is defined as the natural person who is assigned to an email address by an internet access provider, online service provider, or other organization (e.g. business, educational institute) that is responsible for assigning email addresses for the domain associated with the submitted email address. Sponsor is the official timekeeper for this Sweepstakes. Sponsor, in its sole discretion, reserves the right to disqualify any person tampering with the operation of the website or the entry process. In the event the Sweepstakes is entered via a mobile device, Message and Data charges may apply.
PRIZES: Ten (10) prizewinners will each receive a one-year subscription to Reminisce. The approximate Retail Value (ARV) of each prize is $10.00. The total ARV of all prizes in this Sweepstakes is $100.00. Each prize is not transferable, and cannot be assigned, substituted or redeemed for cash. Sponsor reserves the right to substitute a similar prize of equal or greater value in the event that any of the stated prizes cannot be awarded for any reason. All taxes, if any are the sole responsibility of the winners. Neither the Sponsor nor its affiliates or subsidiaries will be responsible for any loss, liability or damage arising out of the winner's acceptance or use of the prize.
SELECTION OF WINNERS: Winners will be selected by random drawing from all eligible entries within five days of the Sweepstakes Deadline Date by Sponsor, whose decisions are final in all respects. Odds of winning depend on the number of eligible entries received. Approximate odds of winning are estimated at 1 in 5,000. Winners will be notified by mail and/or email within 14 days of the drawing and may be required to execute a Statement of Eligibility and Release within 14 days of prize notification attempt or winner will be disqualified and prize may be awarded to an alternate winner. Return of prize or prize notification as undeliverable will result in disqualification and an alternate winner may be selected. In the event winner is a minor in his or her place of residence all required documentation must be signed by parent or legal guardian. If any winner is a resident of Canada, he or she will also be required to answer a mathematical time-limited skill-testing question. Failure to answer the question correctly, as determined by Sponsor in its sole discretion, will result in disqualification and, at Sponsor's discretion, an alternate winner may be selected. Entry and/or acceptance of prize(s) constitutes permission for the Sponsor and its agencies to use the winner's name, address (city and state/province) and/or likeness for advertising and trade purposes without further compensation or authorization, worldwide and in perpetuity, in any and all forms of media, now known and hereafter devised, unless prohibited by law.
CONDITIONS: By entering, participants agree to be bound by these complete Official Rules. Sponsor, is not liable for, late, lost, delayed, damaged, misdirected, incomplete, garbled or jumbled, stolen, postage due mail or illegible entries or for printing, distribution or production errors. Sponsor is not liable for any malfunctions or failures of any telephone network or lines, computer internet system, servers or providers, computer equipment, software, failure of any email on account of technical problems or traffic congestion on the internet or at any website, or any combination thereof, including any injury or damage to participant's or any other person's computer, mobile or other device and/or its contents related to or resulting from participation or downloading any materials relating to this Sweepstakes, or other technical difficulties or failures or other errors of any kind. Any person attempting to defraud or in any way tamper with this Sweepstakes will be ineligible for prizes and may be prosecuted to the full extent of the law. Sponsor reserves the right to terminate or modify the Sweepstakes at any time for any reason. In such circumstances prizes will be awarded based on entries received to date of termination. All prizes will be awarded.
CONSUMER INFORMATION: Sponsor may share customer information about you with reputable companies in order for them to offer you products and services of interest to you. If you would rather we not share information, wish to receive a list of winners, or you do not want to receive future sweepstakes or skill contest mailings from Sponsor, specify your request in writing to Reminisce Extra Hattie's Hatpin Sweepstakes, PO Box 50005, Prescott, Arizona 86301-5005. Request for list of winners must be received within one year of the Sweepstakes Deadline Date.
*Odds of winning depend on the number of eligible entries received.
ALL ENTRIES HAVE THE SAME CHANCE OF WINNING. No one will know who the winner is until after the sweepstakes ends. Final Closing Date is the last date entries are accepted. See Official Rules for details.
ENTRY IS FREE. You don't have to buy anything to enter. Just enter as instructed. You will be entered for the prize offered in this sweepstakes.
BUYING WON'T HELP YOU WIN. Your chances of winning without a purchase are just as good as the chances of someone who buys something.


text:
package tlvparse

import (
	"encoding/binary"
	"unicode"
	"unicode/utf8"

	"github.com/webnice/web/v2/proxyp"
)

const (
	// pp2_tlv_ssl.client  bit fields
	PP2_BITFIELD_CLIENT_SSL       uint8 = 0x01
	PP2_BITFIELD_CLIENT_CERT_CONN       = 0x02
	PP2_BITFIELD_CLIENT_CERT_SESS       = 0x04

	tlvSSLMinLen = 5 // len(pp2_tlv_ssl.client) + len(pp2_tlv_ssl.verify)
)

// 2.2.5. The PP2_TYPE_SSL type and subtypes
/*
   struct pp2_tlv_ssl {
           uint8_t  client;
           uint32_t verify;
           struct pp2_tlv sub_tlv[0];
   };
*/
type PP2SSL struct {
	Client uint8 // The <client> field is made of a bit field from the following values,
	// indicating which element is present: PP2_BITFIELD_CLIENT_SSL,
	// PP2_BITFIELD_CLIENT_CERT_CONN, PP2_BITFIELD_CLIENT_CERT_SESS
	Verify uint32 // Verify will be zero if the client presented a certificate
	// and it was successfully verified, and non-zero otherwise.
	TLV []proxyproto.TLV
}

// Verified is true if the client presented a certificate and it was successfully verified
func (s PP2SSL) Verified() bool {
	return s.Verify == 0
}

// ClientSSL indicates that the client connected over SSL/TLS.  When true, SSLVersion will return the version.
func (s PP2SSL) ClientSSL() bool {
	return s.Client&PP2_BITFIELD_CLIENT_SSL == PP2_BITFIELD_CLIENT_SSL
}

// ClientCertConn indicates that the client provided a certificate over the current connection.
func (s PP2SSL) ClientCertConn() bool {
	return s.Client&PP2_BITFIELD_CLIENT_CERT_CONN == PP2_BITFIELD_CLIENT_CERT_CONN
}

// ClientCertSess indicates that the client provided a certificate at least once over the TLS session this
// connection belongs to.
func (s PP2SSL) ClientCertSess() bool {
	return s.Client&PP2_BITFIELD_CLIENT_CERT_SESS == PP2_BITFIELD_CLIENT_CERT_SESS
}

// SSLVersion returns the US-ASCII string representation of the TLS version and whether that extension exists.
func (s PP2SSL) SSLVersion() (string, bool) {
	for _, tlv := range s.TLV {
		if tlv.Type == proxyproto.PP2_SUBTYPE_SSL_VERSION {
			return string(tlv.Value), true
		}
	}
	return "", false
}

// ClientCN returns the string representation (in UTF8) of the Common Name field (OID: 2.5.4.3) of the client
// certificate's Distinguished Name and whether that extension exists.
func (s PP2SSL) ClientCN() (string, bool) {
	for _, tlv := range s.TLV {
		if tlv.Type == proxyproto.PP2_SUBTYPE_SSL_CN {
			return string(tlv.Value), true
		}
	}
	return "", false
}

// SSLType is true if the TLV is type SSL
func IsSSL(t proxyproto.TLV) bool {
	return t.Type == proxyproto.PP2_TYPE_SSL && t.Length >= tlvSSLMinLen
}

// SSL returns the pp2_tlv_ssl from section 2.2.5 or errors with ErrIncompatibleTLV or ErrMalformedTLV
func SSL(t proxyproto.TLV) (PP2SSL, error) {
	ssl := PP2SSL{}
	if !IsSSL(t) {
		return ssl, proxyproto.ErrIncompatibleTLV
	}
	if t.Length < tlvSSLMinLen {
		return ssl, proxyproto.ErrMalformedTLV
	}
	ssl.Client = t.Value[0]
	ssl.Verify = binary.BigEndian.Uint32(t.Value[1:5])
	var err error
	ssl.TLV, err = proxyproto.SplitTLVs(t.Value[5:])
	if err != nil {
		return PP2SSL{}, err
	}
	versionFound := !ssl.ClientSSL()
	var cnFound bool
	for _, tlv := range ssl.TLV {
		switch tlv.Type {
		case proxyproto.PP2_SUBTYPE_SSL_VERSION:
			/*
				The PP2_CLIENT_SSL flag indicates that the client connected over SSL/TLS. When
				this field is present, the US-ASCII string representation of the TLS version is
				appended at the end of the field in the TLV format using the type
				PP2_SUBTYPE_SSL_VERSION.
			*/
			if tlv.Length == 0 || !isASCII(tlv.Value) {
				return PP2SSL{}, proxyproto.ErrMalformedTLV
			}
			versionFound = true
		case proxyproto.PP2_SUBTYPE_SSL_CN:
			/*
				In all cases, the string representation (in UTF8) of the Common Name field
				(OID: 2.5.4.3) of the client certificate's Distinguished Name, is appended
				using the TLV format and the type PP2_SUBTYPE_SSL_CN. E.g. "example.com".
			*/
			if tlv.Length == 0 || !utf8.Valid(tlv.Value) {
				return PP2SSL{}, proxyproto.ErrMalformedTLV
			}
			cnFound = true
		}
	}
	if !(versionFound && cnFound) {
		return PP2SSL{}, proxyproto.ErrMalformedTLV
	}
	return ssl, nil
}

// SSL returns the first PP2SSL if it exists and is well formed as well as bool indicating if it was found.
func FindSSL(tlvs []proxyproto.TLV) (PP2SSL, bool) {
	for _, t := range tlvs {
		if ssl, err := SSL(t); err == nil {
			return ssl, true
		}
	}
	return PP2SSL{}, false
}

// isASCII checks whether a byte slice has all characters that fit in the ascii character set, including the null byte.
func isASCII(b []byte) bool {
	for _, c := range b {
		if c > unicode.MaxASCII {
			return false
		}
	}
	return true
}

redpajama_set_name: RedPajamaGithub


Demetra has 6 years of accounting, audit, tax and VAT experience, where she has gathered expertise in the areas of tax and VAT, preparing financial statements and auditing entities in the investment and finance sectors as well as trading companies, including both local and international clients.
She also has experience in advising on VAT and tax issues of both local and international clients, as well as providing tax opinions. She also works on transfer pricing and tax due diligence projects.
She is handling all GDPR issues of the Company and of clients.


text:
Q: Can the verb "roll" be used for an object that does not move? I would like to know which of "roll" and "rotate" is better in the following sentence I created.

A printer has a roller inside to feed paper. The roller is supported by a shaft to a printer casing and rolls/rotates on the shaft.

I looked up "roll" in some dictionaries and found that it is usually used for a moving object, so I think "rotate" is better in the above sentence, but the name "roller" causes me to use "roll".

A: I would also use "rotate", but only because it avoids the repetition of "roll"
Dictionary.com has "to revolve or turn over, once or repeatedly, as a wheel on an axis" as its tenth meaning of "roll". So it is correct to say "the roller rolls on the shaft"

redpajama_set_name: RedPajamaStackExchange


We investigate 1D correlated systems following a photoexcitation by combining ab-initio methods, time-dependent matrix product state (MPS) approaches, analytical insights from quantum Boltzmann equations, and molecular dynamics (MD) simulations to describe the dynamics on different time scales ranging from femtoseconds up to nanoseconds. This is done for manganite systems in the material class Pr1?xCaxMnO3. We derive one-dimensional ab-initio model Hamiltonians for which we compute the ground states at different values of the doping using MD simulations. At half doping, we obtain a magnetic microstructure of alternating dimers which we use as a starting point to formulate a one-dimensional Hubbard-type model. In this strongly correlated 1D system we address the formation of quasiparticles after photoexcitations. The dynamics is analyzed concerning the formation and lifetime of such quasi-particles via a linearized quantum Boltzmann equation. In this way, our work constitutes a first step to building a unifying theoretical framework for the description of photoexcitations in strongly correlated materials over a wide range of time scales, capable of making predictions for ongoing experiments investigating pump-probe situations and unconventional photovoltaics.


text:
The University of North Carolina in tags
The University of North Carolina in domain names
university-directory.eu Universities & Colleges worldwide - University Directory
TOP ranked Universities & Colleges in Higher Education listed by University Directory. 51151 institutions, 157326 job vacancies, 550777 courses & programs
News job jobs
universe.byu.edu U N I V E R S E
We are BYU.
Immigration Nation Nauvoo Revisited popular articles
universities.com Universities | Online Degrees | Online Colleges | Universities.com
At Universities.com, our mission is connecting you with the information you need to reach your goals. Get valuable free information about online degrees now!
distance education learning
The University of North Carolina in titles
unc.edu University of North Carolina at Chapel Hill
Menu. A new title: Robertson Scholar. "You can't control every factor". 20 years of Yucatec Maya. Building collaborative approach to genome sciences. William C. Friday, 1920-2012. The money was gone. Cuban Missile Crisis no morality play. Driving through time. Sarah Browning. Sahle pushes positiv...
The University of North Carolina The University of North Carolina at Chapel Hill UNC
ncsu.edu North Carolina State University
Learn more about North Carolina State University, located in Raleigh, N.C., and consistently recognized as one of the nation's top public universities.
News engineering extension
appstate.edu Appalachian State University :: Boone, North Carolina
Nestled in the Blue Ridge Mountains of North Carolina, Appalachian State University offers a challenging academic environment, energetic campus life and breathtaking location.
Boone Humanities admissions
uncg.edu The University of North Carolina at Greensboro
The University of North Carolina at Greensboro. LATEST HEADLINES. UPCOMING EVENTS. IMPORTANT LINKS. SITE TOOLS. Copyright © 2013. The University of North Carolina at Greensboro. All rights reserved..
The University of North Carolina at Greensboro University North Carolina - Greensboro University of North Carolina - Greensboro
uncw.edu University of North Carolina Wilmington
The UNC Wilmington, the state's coastal university, is dedicated to learning through the integration of teaching and mentoring with research and service. Learn more and apply online.
UNC UNCW University of North Carolina Wilmington
The University of North Carolina in descriptions
wfu.edu Wake Forest University
A collegiate university in Winston-Salem, North Carolina distinguished by small classes and faculty-student engagement.
MBA college graduate school
elon.edu Elon University
Elon is a selective private liberal arts university in North Carolina renowned for engaged and experiential learning.
Elon University Special Initiatives arts university
dukemedicine.org Duke Medicine
Transforming medicine and health care in North Carolina and around the world. News From Duke. Noteworthy. Top Navigation. Robert Lefkowitz, MD, Receives 2012 Nobel Prize in Chemistry. Duke University Medical Center Advances in National Hospital Rankings (DukeHealth.org). Duke Medicine Constructio...
Duke Medicine health care north carolina
data.princeton.edu GR's Website
Biographical Notes. Research. Teaching. Service. I was trained as a Biostatistician at the University of North Carolina at Chapel Hill, and before that obtained a Master's degree in Social Science at the University of Chicago. My undergraduate work in my native Chile was in Psychology, where I di...
Biographical Notes GR's Website
ils.unc.edu UNC School of Information and Library Science
University of North Carolina School of Information and Library Science
Library School SILS UNC SILS
sat-expert.com
maulnet.ru
dam.mellis.org
downloadpipe.com
a4uexpo.com
johnnyholland.org
gdi-solutions.com
betterseeker.com
learnnc.org
mactechnews.de
forumer.com
woltlab.com
inflibnet.ac.in
mysql-php.lerneniminternet.de
angool.com
hshs.org
tolliez.com
kursgrivny.narod.ru
blogdecarloscorrea.com

redpajama_set_name: RedPajamaCommonCrawl


1. Fully Grown, Adult, Big, Full-Grown, Grown, Grownup : بالغ - پختہ : (of animals) fully developed.
Animal, Animate Being, Beast, Brute, Creature, Fauna - a living organism characterized by voluntary movement.
Developed, Highly-Developed : بہت ترقی یافتہ : (used of societies) having high industrial development. "Developed countries"
Fulminant : شدید : sudden and severe.
Full-Bosomed : بڑی چھاتیوں والی عورت : (of a woman`s body) having a large bosom and pleasing curves.
How this page explains Fully Grown ?
It helps you understand the word Fully Grown with comprehensive detail, no other web page in our knowledge can explain Fully Grown better than this page. The page not only provides Urdu meaning of Fully Grown but also gives extensive definition in English language. The definition of Fully Grown is followed by practically usable example sentences which allow you to construct you own sentences based on it. You can also find multiple synonyms or similar words on the right of Fully Grown. All of this may seem less if you are unable to learn exact pronunciation of Fully Grown, so we have embedded mp3 recording of native Englishman, simply click on speaker icon and listen how English speaking people pronounce Fully Grown. We hope this page has helped you understand Fully Grown in detail, if you find any mistake on this page, please keep in mind that no human being can be perfect.


Mold growing inside your home or business is a serious concern that should be addressed as soon as possible. Mold spores are known to cause allergic reactions and respiratory issues for some, making life both miserable and unhealthy. The presence of long-term mold growth can also lead to structural concerns including weakened or rotting wood. If you discover mold in your property, don't delay!
When you contact Water Out Now in regards to mold removal, you will be greeted by friendly personnel who will answer any questions that you may have. A member of our experienced team will visit your property to examine the mold growth and will provide you with a detailed estimate for removal.
If you have mold growing in your home or business, you should always ask, "where did it come from?" Most often, mold growth occurs as a result of water damage. If your property recently suffered a water loss, you will be at greater risk of developing a mold problem. Undiscovered water damage, such as from a slow leak, can also contribute to mold growth. Our team is qualified to handle both the water damage and the mold removal.
We remove mold using a technique called "dry ice blasting" which is a state-of-the-art method that shoots pressurized ice crystals at mold, clearing it on contact. It is the best method for mold removal, bar none. It is safe, effective, and chemical-free.
Our technicians are friendly and trustworthy, as well as experienced and qualified. We will make sure that throughout the mold removal process exposure is limited, and steps are taken to prevent mold spores from traveling to other areas of your property. Our mold removal method is safe and chemical-free, so you don't need to worry about your children or pets safety during the removal process.
We strive to provide exceptional customer service that makes our customers feel like family. We go the extra mile when it comes to making sure each need is met. Our goal is to ensure that all work is done properly and effectively. Call us today to schedule an appointment and to obtain an estimate. We offer mold removal services in Columbus, Dublin, Gahanna, Hilliard, Westerville, Delaware, Findlay, Toledo, Ottawa, Lima, Marion, and the surrounding communities.


To cancel your Ford Credit financing, contact them directly through the links below.
In addition to financing, we provide the latest Ford vehicle information, special offers, even pre-approval for your next Ford purchase or lease. Did we mention we also finance products that protect your vehicle and your investment? Well, we do. We offer maintenance programs that can save you money. Like programs that can protect you against lease-end excess wear and use charges, if you choose to lease. None of this, of course, is available from banks and other lenders. With Ford Credit you can pay your bill, set up automatic payments, edit your profile and much, much more, anytime, 24/7. And we offer the convenience of doing it all online from your computer or your mobile device.


text:
Shielding normal cells from radiation therapy
An Israeli-developed biodegradable 'balloon' separates tumors from healthy tissues, greatly reducing side effects of radiation therapy in prostrate cancer.
By Daniel Ben Tal	January 5, 2012, 12:00 am
ProSpace device ready to insert the balloon.
The well-known problem in cancer radiation therapy is that it indiscriminately zaps both malignant and healthy tissues. But what if it were possible to shield normal cells from the powerful rays?
BioProtect, one of a cluster of notable Israeli biotech innovators, has come up with a unique solution that accomplishes this task for prostate cancer sufferers. Its ProSpace biodegradable balloon keeps radiation from healthy tissues surrounding the tumor.
This type of cancer was a logical place to start because of the prostate's proximity to the rectum. Radiation therapy for the cancer can inadvertently cause soreness, diarrhea, perforation, and severe bleeding or bloody discharge.
"It's a quality of life issue," BioProtect CEO Amir Shiner tells Israel21c, noting that radiation therapy can also result in health conditions that require significant interventions. "There's a real need for such a protection device."
Made from biodegradable polymers, the balloon is implanted in a simple, minimally invasive procedure and dissolves within three to six months.
Nearly 50 percent of cancer patients in the United States are treated using radiation therapy, and ProSpace may have a role in offering many of them a safer and more enhanced radiation therapy experience.
According to the American Cancer Society, approximately 12 million new cases of cancer are diagnosed globally each year, and the incidence of cancer is expected to rise in the coming years.
BioProtect is aiming its breakthrough technology at the European market first. In October 2010, the device received the CE Mark, which certifies that a product conforms with European regulatory requirements. The company is now establishing its marketing network throughout the continent.
Shiner calls it a "soft launch process."
"We already have initial sales in Europe. We started in Italy in April, and have since signed distribution agreements in five European countries. Right now, we're working to validate the product's position in the market and are negotiating to expand further in Europe."
In Israel, the Health Ministry approved the ProSpace for marketing last July.
The company has already carried out a pilot study for the US Food & Drug Administration, and is now in the process of finalizing the clinical requirements to obtain clearance to sell ProSpace in the US.
The balloon is inflated to protect the healthy cells.
Researching, developing and marketing a breakthrough technology requires deep pockets. Three groups of investors are backing BioProtect: Virginia Life Science Investments, a major investor in Israeli healthcare companies; the JumpStart NJ Angel Network; and Xenia Venture Capital, operator of the Kiryat Gat technological incubator that nurtured the company as a startup. There also several private investors.
"Right now, we're working on more significant fundraising to take us to the next stage," says Shiner. "We're a small company, based in Kfar Saba, with a highly dedicated R&D team. Manufacturing is on site."
After completing preclinical studies, BioProtect recruited 24 patients for its multi-center pivotal study for the European market, which involved VCU Massey Cancer Center and VA Urology Medical Centers in Virginia, the Montefiore Medical Center in New York City, Luebeck University Hospital of Schleswig-Holstein in Germany, the Padova University Hospital in Italy and Tel Aviv's Sourasky Medical Center.
In March this year, Padova Hospital urologist Fabrizio Dal Moro reported to the European Association of Urology's 26th Annual Congress that inserting ProSpace between the prostate and rectum has been shown to reduce the volume of rectum exposed to radiation by 69.9%, which he called "a dramatic reduction."
In January next year, the company is to launch a further study utilizing ProSpace for an innovative radiation therapy protocol at several Israeli medical centers.
Shiner says that the feedback from the field has been extremely encouraging.
"Physicians tell us that they prefer our product to the only alternative available — a gel that is injected and performs a similar role. The great advantage of the ProSpace device is that it's reproducible. Its well-defined boundaries under a CT scan, and reproducible shape and size, help the doctor to effectively administer their treatment."
What's more, patients report little or no pain from the implanted balloon, although they occasionally experience mild and temporary discomfort at the access area.
There are other advantages, Shiner notes: ProSpace enables more efficient treatments using more concentrated radiation doses, meaning fewer treatment sessions at a lower cost.
Read more on: Health, Medical devices, radiation, cancer treatment
More about Health
18 outdoor workout spots keeping Israelis fit during Covid
By Tess Levy and Danya Belkin
How Israel has leapt ahead in the vaccine race
By Daily Mail
Doctors get jiggy with it as they line up for Covid shots
Israel has given most Covid-19 vaccines per capita


text:
La cinoglosa, bizniega, lengua de perro (traducción de cynoglossum), oreja de liebre o viniebla (Cynoglossum officinale L.) es una especie de planta de la familia de las boragináceas.

Distribución y hábitat
Es una planta que crece en las zonas templadas de Europa, Asia y Norteamérica, en calveros, laderas pedregosas, terrenos incultos y bordes de caminos. En España medra en las montañas septentrionales, especialmente en los Pirineos.

Descripción
Es una planta herbácea vivaz de 3-60 cm de altura. Las hojas son ásperas, anchamente lanceoladas, enteras y pecioladas, parecidas a una lengua de perro, que desprenden un fuerte olor a ratón cuando se restriegan. La flor, de mayo en adelante, es  púrpura, madura sus frutos a partir de julio, agrupándose en panículas terminales. Las semillas poseen unos pequeños garfios que se enganchan en la piel de los animales para su difusión.

Propiedades
 Para el tratamiento de catarros y la tos
 Antidiarréico.
 Es tóxico para los animales de sangre fría y poco para los mamíferos. Acción paralizante sobre nervios motores similar a la del curare en algunas especies.
 Usado para el tratamiento de las hemorroides.
 Antiguamente era considerada oficinal, hoy solo se utiliza en homeopatía.

Taxonomía
Cynoglossum officinale fue descrita por Carlos Linneo y publicado en Species Plantarum 1: 134. 1753.
Etimología
Cynoglossum: nombre genérico que deriva del griego cyno = "perro" y glossum = "lengua", refiriéndose a su parecido con la lengua de un perro.

officinale: epíteto latino que significa "planta medicinal vendida en herbarios".
Citología
Número de cromosomas de Cynoglossum officinale (Fam. Boraginaceae) y táxones infraespecíficos: n=12
Sinonimia
 Cynoglossum foetens Gilib.
 Cynoglossum rotatum Velen.
 Cynoglossum ruderale Salisb.
 Cynoglossum vulgare Gueldenst. ex Ledeb.

Nombre común
Castellano: bizniega, cinoglosa, cinoglossa, cynoglossa, cynoglossa vulgar, hierba conejera, hierba del conejo, lapilla, lengua canina, lengua de perro, lingoa de caô, mareacavallo, matacavallo, oreja de liebre, orejas de liebre, orelha de lebre, viniebla, viniega, yerba conejera.

Referencias

Enlaces externos

officinale
Plantas medicinales

redpajama_set_name: RedPajamaWikipedia


text:
Madness? This. Is. Japan!
Available on: PC (via Steam), Mac
There are moments in life when you're left wondering "what the hell did I just see?" Things that baffle you beyond reason. Hatoful Boyfriend is one of those things. It's no secret that some cultural peculiarities of the Asian world will always puzzle us Westerners (and vice-versa), particularly in the entertainment sector. But this…
First things first: Hatoful Boyfriend, as the name indicates, is a dating sim. This is not a genre I would normally touch with a 10-foot pole, but this game was brought to my attention by an utterly fearless forum acquaintance, who pointed out that, not only was it completely insane, but also surprisingly well-thought out (how's that for a paradox?). My curiosity was piqued, and since I'm always up for unusual experiences, after some deliberation, I decided to take the plunge. There was originally a free demo version available, but trust me, you WANT to get the full version. Not only does it include a secret character, but a substantial extra storyline as well. The latter basically explains the entire backstory of the game (you're in for some shocks, let me tell you), but also puts you in control of a different character and is very different in tone.
The first thought that comes to my mind in association with dating sims is "dirty little secret". It's not the kind of game you'd go trumpeting around the rooftops about. I'm fairly sure, however, that you've never experienced anything quite like this UFO before. I certainly haven't. Let's start with the premise: in the not-too-distant future, a particularly virulent mutation of the avian flu wipes out most of humanity and simultaneously makes birds sapient. Not exactly your usual sappy romance setting. The consequence is that birds take over society, and a human girl (your protagonist) finds herself enrolled in a high-school for gifted birds. All the while living in a cave and hunting for her meals. I'll just let all that sink in for a moment.
Obviously, since there are no humans around at the school, her only romantic prospects lie with birds. And before you start backing off in dubitative disgust, I assure you that nothing sexual ever happens. There isn't even any PDA to speak of. Thankfully, might I add. That's not to say that nothing dodgy ever happens, because one of the potential romantic subplots is steeped in textual gore (and some innuendo). And two others are so WEIRD that no description could ever do them justice. That aside, this premise is also what explains the title of the game; "hatoful" is a play on the word "heartful": "hato" means "pigeon" in Japanese. Not that "heartful boyfriend" makes very much sense in English, but we'll just let that slide. The actual translation of the game is fun and well-executed, barring some rare, bizarre cultural references (not even Japanese ones) and the odd typo/spelling mistake.
The first part of the game is devoted to establishing the setting and introducing the potential romantic interests (except the secret character, whom you'll have to go digging for). For starters, you can pick your character's name at the beginning of the game (the default is Hiroko). You can also opt to have a 'humanised portrait' of each of the eight romance options displayed. Whenever a potential prince charming is first introduced, a title screen with his name and portrait appears. If you pick the humanised option, there will also be a picture of what he would look like if he were human (well, except one of them…he just looks like a bird in both). This greatly helps to make them more relatable. Otherwise, you're stuck with a pigeon, three fantails, a quail, a partridge, a mourning dove and a bleeding-heart. Sexy (not). They are, respectively, the protagonist's best friend, two aristocratic fellow-student brothers and a wacky sports enthusiast, the narcoleptic math teacher, the creepy school doctor, a quiet bookworm and a…well, I guess anime-freak will have to do as a description. Yeah, that's the secret character.
Anyway, the concept is simple: once you decide which birdie makes your character's heart flutter (ho ho ho), you then proceed to win their affection by choosing specific actions or lines of dialogue in conversation or at certain events (there's a sports event, a school festival, fireworks, etc.). You can save at any time, which is helpful if you're at all unsure of what to do. Every once in a while, you'll also have an electives day, where the heroine can choose between attending math, music or gym class, which will raise one of her stats: wisdom, charisma or vitality, respectively. This will affect her chances with some of the options. Some of them even have slightly different outcomes, depending on which stat you choose to boost. Finally, you can also buy some beans for the bird of your choice for the in-game equivalent of Valentine's Day. Each has their preference, so this affects the protagonist's chances as well.
This is all rather straightforward, and the game, additionally, never overstays its welcome, by making each storyline manageably short (about 30 mins). Moreover, you can fast-forward through parts you've already seen by clicking on the arrow in the upper right corner of the screen. Each ending grants you an image in the Gallery, as well as some mysterious notes in the Archive section of the main menu, which add a disquieting undercurrent to things. Once you've seen them all, including a storyline which involves pairing up two other birds who have nothing to do with the school, and a 'bad ending' where the heroine doesn't romance anybody–or "anybirdie", as the game puts it–and, startlingly, gets killed by a group of hawks for it (these two endings can be achieved in one go), you'll have access to the aforementioned extra storyline. It takes longer than the usual playthrough, restricts saving to certain key points, involves all potential romantic interests, with you controlling the best friend, and…let's just say that it's a mix of thriller, horror, melodrama, comedy, romance, RPG and sci-fi. And that it will blow your mind.
You wouldn't expect talking birds to make for particularly relatable characters, and, while I'm not familiar with the conventions of the dating sim genre, I don't suppose that deep character development is a big priority. Surprisingly enough, though, these birds do get their own backstories (most are substantially padded out in the extra storyline), and, after a while, they start feeling like human characters, and you end up empathizing with some of them. Not all romances end well, and not all are equally well executed: there is, for example, a definite bias towards the best friend, Ryouta, who gets the most–rather moving, might I add–content and makes the most sense as a partner. Two of the other romances are also very predictable.
Still, for a game which I had zero expectations for prior to playing, Hatoful Boyfriend turned out to be a thoroughly entertaining surprise. This isn't an all-time-great, by any means, and I certainly wouldn't recommend it to everyone (definitely not to male players), but it you're curious and want to experience something completely different, original and utterly cuckoo (see what I did there?), go right ahead.


The person chooses the way in live to which he aspires, it helps in its physical spirit, as shown on the poster. Judo opens a way of perpetual motion and world development. The knowledge has it major importance for society and thinking development. The people who are engaged in judo, creative activities realize out with the knowledge the person of the opportunities and its performance.
Judo is a sport based on throws, painful methods. During many years the technics of judo changed. In the 19th century the attack and defense changed.Receptions which are dangerous to life and health of sportsman were excluded from judo. Judo was founded by Jigoro Kano in the 19th century on the basis of ju-jutsu. Ju-jutsu techniques include punches, which are now used in modern karate. Creating a new system of method Master Kano removed all dangerous throws from ju-jutsu, replacing them and making a new kind of fighting safer. Work on the creation of struggle at a minimum cost of psychic and physical energy was, conducted for many years. And as a result, objective has been reached ju-jutsu by Jigoro Kano - he has made sports of judo from fighting.
Competitions in judo in Olympic Games for the first time appeared in Tokyo in1964. Originally competitions were male, female disciplines appeared in the 1992 Summer Olympics in Barcelona.
Competitions in judo in Olympic Games of 2012 were held from July, 28th to August, 3rd in London. 14 awards have been played. The combined team of Russia in London won the first gold awards in judo for for the first time in history.
Our athletes won five medals: 3 gold earned by Arsen Galstyan, Mansur Isaev, Tagir Khaibulaev;Alexander Mihailin Ivan Nifontov received a silver medal and a bronze one.
V.V Putin is a master of sports of judo and sambo.He was Leningrad champion in judo.11-years-old Putin's judo coach was Anatoly Rachlin. As Rachlin said,- "Putin fought beautifully".
Judo helps to support itself in an excellent physical form. By means of special exercises of people develops in itself flexibility, dexterity. Judo teaches the person to keep tranquillity in any situations. Struggle trains not only a body, but also mind. The person can quickly find solutions. The main task of judo is self-defense. The person will be able to stand for himself and people around. Judo teaches also to an order. You will become many organized, responsible and focused.


– Experience & Understand real life situations in research institutions & industrial organizations and getting acquainted with the sophisticated equipment and the ability to interpret the experimental data.
– Learning accepted safety practices in the industry.
– Developing personality & communication skills for future roles as Managers in biotechnology industry.
– Understand the formal and informal relationships in an industrial organization so as to promote favorable human relations and teamwork.
– Develop a sense of responsibility towards society.


text:
Debtor's Obligation to Pay his Children's College Expenses Qualified as a DSO and Were Non-Dischargeable
Bobby Wilbert | Latest News | February 22, 2018
Stephen and Judith were divorced in 2009 after a 21-year marriage. During their marriage, Stephen worked for Southwest Airlines and his wife stayed home to care for their three children, Sarah, Kate, and John.
The divorce decree incorporated a marital settlement agreement signed by Stephen and Judith. This agreement included a "College Education" provision, which stated that following exhaustion of their college savings accounts, "Husband shall pay the costs of tuition, room and board, books, registration fees, and reasonable application fees incident to providing each Child with an undergraduate college education for four consecutive years of college."
Stephen did not meet his obligations under the college education provision, which led Judith to file a motion in Maryland state court to enforce the marital settlement agreement. This motion was resolved in 2011 through a consent order. In the order, Stephen reaffirmed his obligation to pay his children's college expenses under the marital settlement agreement, including repayment of student loans to the two oldest children.
Stephen later failed to pay John's college expenses, and Judith filed another action in state court to enforce the marital settlement agreement and the 2011 consent order. This action was resolved by a second consent order. There Stephen agreed to contribute up to $14,000 per academic year toward John's college expenses. After Stephen again failed to comply, the state court found him in contempt and awarded judgment to Judith for $14,000 (Stephen's share of the first year of John's college tuition) and the attorney fees incurred by Judith to enforce the marital settlement agreement. When Judith initiated collection efforts, Stephen filed bankruptcy.
Judith filed a proof of claim, which included
• the amounts still owed on Sarah and Kate's undergraduate student loans and
• the amount that Stephen had agreed to pay toward John's college expenses.
According to Judith, these amounts constituted "domestic support obligations" under 11 U.S.C. § 101(14A), creating priority claims that must be fully repaid. See 11 U.S.C. § 1322(a) (requiring full payment of priority claims). Stephen objected, arguing that
• his obligation to pay the children's college expenses did not constitute a domestic support obligation and
• Judith's claim was invalid because she was not a proper party and had not proven the amounts claimed.
After an evidentiary hearing, the bankruptcy court
• sustained Stephen's objection to $8,632.85 of the amount claimed by Judith and
• found that $108,085.08 of the debt constituted a domestic support obligation and created a priority claim.
Stephen appealed in district court, which affirmed. He now appeals to our court


text:
Kelly discusses confidence in Wimbush, defensive line heading into matchup against Wolverines
Elizabeth Greason | Wednesday, August 29, 2018
It all comes down to 7:43 p.m. That's when the Irish will kick off against long-time enemy Michigan after a four-year hiatus to the series.
Irish head coach Brian Kelly previewed the game — a matchup under the lights to be featured on ESPN's College GameDay — during his weekly Tuesday press conference and expressed confidence in his squad's preparedness for the marquee matchup, which Michigan head coach Jim Harbaugh reached out to Kelly to renew.
"Sometimes as you go into these press conferences you forget about the fact that as you give the proper accolades to your opponent, I don't want to forget our football team," Kelly said. "We have got a very, very good football team, really proud of the work that our guys have done and we have got some really good football players too and are excited about watching them compete as well."
Observer File Photo | The Observer
Irish senior wide receiver Miles Boykin sprints off the line of scrimmage during Notre Dame's 21-17 win at the Citrus Bowl against LSU. Boykin had the game-winning 55-yard touchdown with under a minute left.
The Offense
Kelly reiterated once again that quarterback Brandon Wimbush had won the starting job under center and expressed his confidence in the senior to lead the Irish to victory, although he added that he also held complete confidence in junior Ian Book as Wimbush's backup, should he ever have to see game action this season.
"So, Brandon's our starter. We're going to go into the game that he needs to win the game for us," Kelly said. "We'll put a game plan together for Brandon Wimbush to win the game for us. If there's any need, we feel great about Ian Book as our No. 2."
Wimbush, last season's starter, had a tendency to break away for big plays, but Kelly also noted he often did the opposite: freezing up. He is hoping to hand Wimbush the reins to the offense without fearing he will fail in tough situations.
"We can't have a fear of failure at [the quarterback] position. We're going to make mistakes," Kelly said. "We have to understand the difference between letting our guys make plays and be who they are versus being paralyzed with fear of failure. And Brandon falls under that category. At times, he got himself in a place where he didn't want to fail. The quarterback position can't be that. You have to be a guy that is out there making plays. Now, within the scope of the offense, we're not drawing it up in the sand. But he's a playmaker and he's got to go out there with the confidence to make plays. He's going to make some mistakes but as long as he understands that within the scope of the offense making good decisions, he's a smart kid, he cares, but it can't be that we're handcuffing him that he can't go out there and make plays."
Kelly also expanded on the wide receiver rotation, saying that on top of seniors Miles Boykin and Chris Finke and junior Chase Claypool, who are expected to see significant playing time, true freshman Kevin Austin and sophomore Michael Young have also made names for themselves over the course of the offseason and will find themselves as parts of the rotation.
"I think you're going to see Kevin Austin's going to be part of it, Michael Young's going to be part of that rotation," Kelly said of the wide receiver group. "I think those two guys have proved themselves to be part of it as we move forward. You know that we play three and four tight ends, so I think you have to include that as part of what we do. And then the multiple running back situation. So, I wouldn't look just as just being a wide receiver group as much as incorporating tight ends and running backs into all of that being pass receivers and touching the football."
However, one of the question marks on the offense that was left unanswered is whether or not junior running back Dexter Williams will see game action Saturday against the Wolverines. Unconfirmed reports have stated that Williams has been suspended for four games, the first of which will be the Michigan matchup.
"He'll be dressed and he'll be on the sideline and we'll see what happens when we kick it off," Kelly said of Williams' status for Saturday.
The Defense
Kelly noted the progress he has seen at the safety position throughout the offseason.
"I know that we are further along in terms of their ability to impact the game at the safety position and where we need them to be for us to play the kind of defense necessary to beat Michigan," he said. "[Junior transfer] Alohi Gilman has been a guy that has changed it immediately and then I think all the other safeties that played for us last year are further ahead from where they were last year. From [junior] Jalen Elliott to [senior] Nick Coleman, to [junior] Devin Studstill to [senior] Nicco Fertitta to [freshman] Houston Griffin. And I really think you may see multiple players and us taking advantage of all of their skillsets on Saturday night."
Kelly also said he is pleased with the strength he believes this team's defensive line possesses, as its depth will allow the Irish to go head-to-head with a team like Michigan for a full four quarters.
"This will be the deepest defensive line that I've had at Notre Dame and look, when you can go and play — and we can play eight on the defensive line without feeling as though we have to cover somebody up — that's pretty good," Kelly said. "And how that impacts what we're doing is that we can stay after you for four quarters when you can go eight deep. There's not going to be a drop off in terms of somebody has to play 60 or 70 snaps. That's where you'll see ultimately the biggest difference. … But when somebody can be fresh and keep getting after somebody, it changes the way that person looks in the third and fourth quarter. So, this will be the deepest group that we have put out there and we expect it to have great production for us."
Tags: Alohi Gilman, Brandon Wimbush, Brian Kelly, Chase Claypool, Chris Finke, Dexter Williams, Houston Griffith, Kevin Austin, Michael Young, Miles Boykin, ND Football
About Elizabeth Greason
Elizabeth is a senior studying civil engineering from New York, NY (yes, the actual city). She is a proud resident assistant in McGlinn Hall and is a die-hard Mets and Giants fan. She is currently serving as assistant managing editor of The Observer and she also has an obsession with golf that is bordering on unhealthy.
Contact Elizabeth
Brian Kelly discusses defense, skill positions after first post-break practice
The spring season marches on. Notre Dame held its first practice coming back from...
Dexter Williams returns as Notre Dame topples Stanford in extensive offensive showing
Irish rally past Trojans to earn undefeated regular season
Kelly breaks down Iowa State following Camping World Bowl announcement
Tweets by @ObserverSports


I never set out to go into the business of email.
had a thing called the Lieberman queue.
they were assigned a sort of community service to the department.
And mine was maintaining this ancient email system on Top's Ten.
that I got motivated to just rewrite a system on Unix.
that's enough of that and I did my thesis in user interface design.
like to stay here for a while and build the world's greatest mail system?
Email was a text thing in English only.
they only worked within national or linguistic communities.
used a computer there he wouldn't be able to read Japanese email.
So that was clearly not an optimal situation.
Also back then we didn't have just the Internet.
We had a whole bunch of networks.
We had Bitnet, we had Usenet, there were, Nanocef net.
And people sent mail to each other across these networks.
made a message better, right?
The best you could hope for is that it doesn't make it worse.
So, there were a number of problems.
what really got me thinking standards was this.
and he immediately tried to hire our whole team and nobody went.
I suspect that was one of his worst days ever in hiring.
he put together a team to build a multimedia mail system.
So NeXTMail is sort of an imitation of the Andrew mail system.
I didn't have any problem with it.
my users couldn't send pictures to his users because we weren't doing it the same way.
So I started thinking, there really needs to be a standard here.
worrying about the language problem.
Worrying about getting non-English characters in other languages into email.
And there was a third problem.
There were people who worked on gateways.
This gateway problem I described before.
a higher level of information to some of these other systems.
So what MIME was, was a fortuitous coming together of those three needs.
Einar Stefferud, who is one of the great unsung heroes of the Internet.
He was on the Internet from the early 70s.
He started the first Internet mailing list.
I think didn't get as much credit as he should have because of that.
Anyway he introduced me to Ned Freed. Ned was working on gateway issues.
I was interested in the multimedia issue.
And what's good about that from a standard perspective is bandwagon.
want to get the multilingual mail.
multilanguage, and gateway, you had a lot of people concerned.
people involved there's going to be differences of opinion.
not all of them as actively as others.
a half I think to produce what we considered a stable first draft.
The first one then was published was an RFC.
And it was a roaring success almost overnight.
I was updating it to follow each version of the draft.
it would call programs that could display the MIME parts.
started working with this cool stuff, languages, pictures.
And so that made it, that made the adoption incredibly fast.
then I released the Metamail software, and I started getting patches for it.
You know, people augmenting it, the next day.
I got the patches for the DOS port and the Amiga port.
And at that point I was pretty sure I was on to something.
can we pretty much trace what we're doing today all the way back to MIME 1.0?
I also need to say that MIME is one of the ugliest things I've ever seen.
It's a tower of hacks.
Honestly it is, and that's one of the reasons it was successful.
We had a tremendous problem, issue, of compatibility with the installed base.
a lot of software that wasn't going to be thrown out.
that led to MIME being ugly.
But because it was designed with that in mind, it was ready for adoption.
was almost a version two of something else, in one sense, which is X.400.
which was supposed to replace the whole TCP/IP stack, and never did.
and would be very hard to integrate with existing mail systems.
And so, our more simplified approach was a reaction to that.
So for example, 80 column lines.
The limit's a little longer than that but basically limited line lengths.
It dates back to teletypes.
Actually it goes further back than that.
and this went on from them.
less because punch card machines were 100 years ago.
that's why it took off like a rocket, I think.
mail from a fellow who was working on this project in Switzerland I had never heard of.
And he said I'm working on a project called the World Wide Web.
we were thinking that MIME might be the way to do it.
Do you have any opinions or ideas?
off like a rocket either.
>> Really being able to mark in a common language between MIME and HTTP.
There are several parts of MIME and certainly they aren't all used by the Web.
as you say, is the content type registry.
weird type of data that I've just invented, I have to label that somehow.
to go to for something that you want to be interoperable semi-permanently at least.
something between 10 and 20.
wanted to do had an easy way to identify the data for the Web and for email.


text:
The Knights Party
the Premier Voice of America's White Resistance
A Special Message
For Christians
Fellow Patriots
A Message To Our Young Supporters
Online Activism
Why the Klan
Help The Knights
A Short Intro to The Knights
[ October 27, 2022 ] Protect Our People Uncategorized
[ January 30, 2023 ] Knights Party Press Release: Jan. 30. 2023 Press Releases
HomePress ReleasesKnights Party Press Release: Aug. 10. 2022
Knights Party Press Release: Aug. 10. 2022
August 10, 2022 Paul Brown Press Releases 0
No need to read '1984' by George Orwell…we're living it! "The FBI And DOJ Criminalizing Opposition To The Regime Is How The Republic Ends", was a headline from The Federalist, on Monday, August 8th.
On Thursday, Barack Obama's Attorney General Eric Holder decided it was the time to bring the subtext of the Jan. 6 show trials and related domestic security state activities into the open.
"My guess is that by the end of this process, you're going to see indictments involving high-level people in the White House, you're going to see indictments against people outside the White House who were advising them with regard to the attempt to steal the election, and I think ultimately you're probably going to see the president, former president of the United States indicted as well," Holder told SiriusXM host Joe Madison.
Holder noted that the U.S. Department of Justice he formerly headed is working with the illegally constituted Jan. 6 Commission towards this goal. We know these entities are also working with the FBI, whose head bit his thumb at congressional oversight repeatedly in a public hearing last week.
Thomas Robb, the National Director of the Knights Party of the Ku Klux Klan, based in Harrison, Arkansas spoke saying, "Eric Arthur Blair, who used the pseudonym 'George Orwell', wrote a book in 1949, titled '1984', which he warned of upcoming totalitarianism. His book eerily coincides with what we're seeing today in America. What was once wrong, is now right, and what was once right, is now wrong. In a sense, our thoughts are even controlled by our government. I say this because if we speak our thoughts, and they go against the leftist agenda, we're persecuted for having our thoughts. If you're a White, Christian patriot, you're silenced. America is our God-given land, it belongs to White, Christians by God's own hand, yet our government, sworn to protect us, and our land, is taking it from the very people God gave it to. '1984' was written as a fictional book, but is it?"
Knights Party Press Release: Aug. 8. 2022
Donate with Bitcoin
1EhpYZCyQ3RGmGQDxJP3QLCr6gR1hEbJAR
Knights Party Press Release: Jan. 30. 2023
© 2018 The Knights Party


You can activate the Change Management - Risk Assessment plugin (com.snc.change.risk_assessment) if you have the admin role. This plugin includes demo data and activates related plugins if they are not already active.
Change Management - Risk Assessment activates these related plugins if they are not already active.
Provides the core components required for legacy surveys.
Provides simple risk and impact calculations for change management.
Provides survey functionality including triggering survey requests based on task conditions and linking survey responses to the task that generated the survey.
You can define risk assessment conditions for change requests.
Several types of components are installed with the Risk Assessment.


The first spark actually came from an anti-drug special, which featured many of my childhood cartoon heroes teaming up for the first and only time. I was enthralled by the idea of a large group of different heroes working together, and even at a young age, I wanted to tell my own story about them. So I absorbed from everything I could- books, TV, films, even video games, and my group began to take shape. Eventually, I had the characters down well enough that I could begin to focus on a story, and after a lot of planning, I submitted some early pages for a college writing course. I got a lot of encouragement and kept going until the story was complete.
The cover was a long process with a very talented artist named Derrick Fish, whom I met through Facebook. Initially, he did full illustrations of each character, so we'd have a firm base to work from. Once that was done, we discussed having a cover would really jump out and grab the reader's attention. Eventually, I found a cover of a Green Lantern graphic novel showing several different colored Lanterns standing together, and thought it was a very striking image. I e-mailed it to Derrick, and he went from there. I think the cover really does manage to stand out, and show the reader the kind of characters it deals with, while giving just enough detail to make them curious.
I try to take inspiration from everywhere. I read a lot of fantasy and sci-fi, like Terry Brooks and Ray Bradbury, who give a lot of insight into magic and otherworldly, fantastical content. I also got a lot of ideas for mechanics from Avatar the Last Airbender, as well as the Lord of the Ring films and darker-edged 'superhero' movies and comics like the Crow and Batman for it's tortured heroes. I also took a lot from The Legend of Zelda, largely from it's in-game mythology and the multi-faceted worlds the games create.
I am working with a friend on an online comic (Superroomies, on deviantart), but it's largely my writing and his art. I haven't written pen to pen with another author, but if I found the right person and idea, I'd certainly be open to it.
Some of the characters are slight tributes to my influences- some of the Architects, who are the gods of this universe, have names based on Greek mythology. The other names really come from either comic books or my fantasy books. Comics have long-established characters with names like Dr. Polaris or the Trickster, so you learn how to make sound both appropriate to the character, and therefore not so ridiculous you can't say it. And fantasy is chock full of strange names that sound either imposing or heroic or even slimy. So I've seen how just the sound of a name can make or break it for a character.
My books don't really require 'research' since I make a lot of it up. But when I do examine a concept or creature with history, like a gremlin, I try to stick with something I'm familiar with, and see if I can add something to it. I'm all for playing with established concepts, but the core of the concept has to be there. And if it's something new, I find out enough for a profile and then see just what I can do with it.
Very much so. I've been able to set up signings and events largely because of my relationships, and just about everyone I know has bought a book and are spreading it around to other people they know. And they are always eager to give feedback, and ideas for the next novel.
It's hard to pin down. I was always a huge reader, so many people told me I should write. I guess I would have to say when I was thirteen and really started putting pen to paper for the first time.
I love music; I have a side job working as an entertainment reporter for a local paper, and I've been playing bass and guitar for the last four years. I also enjoy biking and movies- I used to bike up to eight miles a day, and I have a huge collection of films, everything from drama to comedies to superhero fare. Comics are also a big interest- they're great sources of inspiration and it's amazing to go over the history of characters that have been around for decades and see how they've changed over the years.
I learned a lot about writing itself- how to keep a scene moving, how not to overwrite or overdescribe, which was essential for me. I also learned a lot about publishing from working with iUniverse- what the standards, how to get the book to it's best state without emptying my wallet, and most of all, how to stand for my book and how I want it to be presented.


text:
Amylolytic enzymes from the yeast Lipomyces kononenkoae
Nivetha Ramachandran, Isak S. Pretorius, Ricardo R. Cordero Otero*
The Lipomyces kononenkoae α-amylases LKA1 and LKA2 belong to the glycoside hydrolase family 13 and exhibit specificity towards α-1,4 and α-1,6 linkages in starch and related substrates. LKA1 exhibits specificity towards α-1,4 and α-1,6 linkages and large amounts of reducing sugars are liberated from highly branched amylopectin and glycogen and linear amylose. LKA2, on the other hand, shows high reactivity towards lintner starch, dextrin and amylase, although only small amounts of reducing sugars are liberated from branched substrates, such as amylopectin and glycogen. These enzymes share the four conserved segments of the catalytic domain found in other members of the family, but have some major variant amino acids within these segments. In addition, LKA1 consists of an N-terminal starch-binding domain (SBD). This is the only α-amylase known to possess this N-terminal domain and it exhibits homology to the N-terminal SBD of Rhizopus oryzae glucoamylase. It shares no homology with the C-terminal starch-binding domains present in the cyclodextrin glucanotransferases, glucoamylases or α-amylases. The evolutionary tree based on the sequence alignment of SBDs reveals that the N-terminal SBDs are separated from the C-terminal SBDs.
Biologia - Section Cellular and Molecular Biology
SUPPL. 16
Dive into the research topics of 'Amylolytic enzymes from the yeast Lipomyces kononenkoae'. Together they form a unique fingerprint.
Lipomyces Medicine & Life Sciences 100%
Amylopectin Chemistry 66%
Glycogen Chemistry 59%
Starch Medicine & Life Sciences 56%
starch Earth & Environmental Sciences 52%
yeast Earth & Environmental Sciences 48%
Amylases Medicine & Life Sciences 43%
Ramachandran, N., Pretorius, I. S., & Cordero Otero, R. R. (2005). Amylolytic enzymes from the yeast Lipomyces kononenkoae. Biologia - Section Cellular and Molecular Biology, 60(SUPPL. 16), 103-110.
Ramachandran, Nivetha ; Pretorius, Isak S. ; Cordero Otero, Ricardo R. / Amylolytic enzymes from the yeast Lipomyces kononenkoae. In: Biologia - Section Cellular and Molecular Biology. 2005 ; Vol. 60, No. SUPPL. 16. pp. 103-110.
@article{76ab693750c044369caafc956d9cc8a5,
title = "Amylolytic enzymes from the yeast Lipomyces kononenkoae",
abstract = "The Lipomyces kononenkoae α-amylases LKA1 and LKA2 belong to the glycoside hydrolase family 13 and exhibit specificity towards α-1,4 and α-1,6 linkages in starch and related substrates. LKA1 exhibits specificity towards α-1,4 and α-1,6 linkages and large amounts of reducing sugars are liberated from highly branched amylopectin and glycogen and linear amylose. LKA2, on the other hand, shows high reactivity towards lintner starch, dextrin and amylase, although only small amounts of reducing sugars are liberated from branched substrates, such as amylopectin and glycogen. These enzymes share the four conserved segments of the catalytic domain found in other members of the family, but have some major variant amino acids within these segments. In addition, LKA1 consists of an N-terminal starch-binding domain (SBD). This is the only α-amylase known to possess this N-terminal domain and it exhibits homology to the N-terminal SBD of Rhizopus oryzae glucoamylase. It shares no homology with the C-terminal starch-binding domains present in the cyclodextrin glucanotransferases, glucoamylases or α-amylases. The evolutionary tree based on the sequence alignment of SBDs reveals that the N-terminal SBDs are separated from the C-terminal SBDs.",
author = "Nivetha Ramachandran and Pretorius, {Isak S.} and {Cordero Otero}, {Ricardo R.}",
journal = "Biologia - Section Cellular and Molecular Biology",
publisher = "Slovak Academic Press Ltd",
number = "SUPPL. 16",
Ramachandran, N, Pretorius, IS & Cordero Otero, RR 2005, 'Amylolytic enzymes from the yeast Lipomyces kononenkoae', Biologia - Section Cellular and Molecular Biology, vol. 60, no. SUPPL. 16, pp. 103-110.
Amylolytic enzymes from the yeast Lipomyces kononenkoae. / Ramachandran, Nivetha; Pretorius, Isak S.; Cordero Otero, Ricardo R.
In: Biologia - Section Cellular and Molecular Biology, Vol. 60, No. SUPPL. 16, 2005, p. 103-110.
T1 - Amylolytic enzymes from the yeast Lipomyces kononenkoae
AU - Ramachandran, Nivetha
AU - Pretorius, Isak S.
AU - Cordero Otero, Ricardo R.
N2 - The Lipomyces kononenkoae α-amylases LKA1 and LKA2 belong to the glycoside hydrolase family 13 and exhibit specificity towards α-1,4 and α-1,6 linkages in starch and related substrates. LKA1 exhibits specificity towards α-1,4 and α-1,6 linkages and large amounts of reducing sugars are liberated from highly branched amylopectin and glycogen and linear amylose. LKA2, on the other hand, shows high reactivity towards lintner starch, dextrin and amylase, although only small amounts of reducing sugars are liberated from branched substrates, such as amylopectin and glycogen. These enzymes share the four conserved segments of the catalytic domain found in other members of the family, but have some major variant amino acids within these segments. In addition, LKA1 consists of an N-terminal starch-binding domain (SBD). This is the only α-amylase known to possess this N-terminal domain and it exhibits homology to the N-terminal SBD of Rhizopus oryzae glucoamylase. It shares no homology with the C-terminal starch-binding domains present in the cyclodextrin glucanotransferases, glucoamylases or α-amylases. The evolutionary tree based on the sequence alignment of SBDs reveals that the N-terminal SBDs are separated from the C-terminal SBDs.
AB - The Lipomyces kononenkoae α-amylases LKA1 and LKA2 belong to the glycoside hydrolase family 13 and exhibit specificity towards α-1,4 and α-1,6 linkages in starch and related substrates. LKA1 exhibits specificity towards α-1,4 and α-1,6 linkages and large amounts of reducing sugars are liberated from highly branched amylopectin and glycogen and linear amylose. LKA2, on the other hand, shows high reactivity towards lintner starch, dextrin and amylase, although only small amounts of reducing sugars are liberated from branched substrates, such as amylopectin and glycogen. These enzymes share the four conserved segments of the catalytic domain found in other members of the family, but have some major variant amino acids within these segments. In addition, LKA1 consists of an N-terminal starch-binding domain (SBD). This is the only α-amylase known to possess this N-terminal domain and it exhibits homology to the N-terminal SBD of Rhizopus oryzae glucoamylase. It shares no homology with the C-terminal starch-binding domains present in the cyclodextrin glucanotransferases, glucoamylases or α-amylases. The evolutionary tree based on the sequence alignment of SBDs reveals that the N-terminal SBDs are separated from the C-terminal SBDs.
JO - Biologia - Section Cellular and Molecular Biology
JF - Biologia - Section Cellular and Molecular Biology
IS - SUPPL. 16
Ramachandran N, Pretorius IS, Cordero Otero RR. Amylolytic enzymes from the yeast Lipomyces kononenkoae. Biologia - Section Cellular and Molecular Biology. 2005;60(SUPPL. 16):103-110.


text:
Q: How does the Java Virtual Machine handle I/O operations? I was looking through the list of Java bytecode instructions and I noticed that there aren't any I/O instructions. That intrigued me. How does the JVM execute methods like System.out.println when it doesn't support I/O instructions?
If it uses some form of memory mapped I/O then how does it communicate with the OS to read file descriptors, etc? Does the JVM implement its own layer of abstraction for handling I/O operations? Are the Java I/O packages (java.io & java.nio) implemented in C/C++ instead?

A: If you look at the library source code, you'll see that all interfacing with low-level APIs (OS etc) is  done using native code.
For example, take FileOutputStream:
/**
 * Opens a file, with the specified name, for writing.
 * @param name name of file to be opened
 */
private native void open(String name) throws FileNotFoundException;

/**
 * Writes the specified byte to this file output stream. Implements
 * the write method of OutputStream.
 *
 * @param      b   the byte to be written.
 * @exception  IOException  if an I/O error occurs.
 */
public native void write(int b) throws IOException;

/**
 * Writes a sub array as a sequence of bytes.
 * @param b the data to be written
 * @param off the start offset in the data
 * @param len the number of bytes that are written
 * @exception IOException If an I/O error has occurred.
 */
private native void writeBytes(byte b[], int off, int len) throws IOException;

And then there's the corresponding C file (often OS-specific).


Compare And Contrast Worksheets 4th Grade with Compare And Contrast Worksheets 4th Grade. Compare And Contrast Worksheets 4th Grade with Compare And Contrast Worksheets 4th Grade. Compare And Contrast Worksheets 4th Grade with Compare And Contrast Worksheets 4th Grade.
Singapore Math 4th Grade Worksheets with Singapore Math 4th Grade Worksheets. Singapore Math 4th Grade Worksheets with Singapore Math 4th Grade Worksheets. Singapore Math 4th Grade Worksheets with Singapore Math 4th Grade Worksheets.
Water Cycle Worksheet 4th Grade with Water Cycle Worksheet 4th Grade. Water Cycle Worksheet 4th Grade with Water Cycle Worksheet 4th Grade. Water Cycle Worksheet 4th Grade with Water Cycle Worksheet 4th Grade.
4th Grade Multiplication Worksheets with 4th Grade Multiplication Worksheets. 4th Grade Multiplication Worksheets with 4th Grade Multiplication Worksheets. 4th Grade Multiplication Worksheets with 4th Grade Multiplication Worksheets.
4th Grade Math Word Problems Worksheets Pdf with 4th Grade Math Word Problems Worksheets Pdf. 4th Grade Math Word Problems Worksheets Pdf with 4th Grade Math Word Problems Worksheets Pdf. 4th Grade Math Word Problems Worksheets Pdf with 4th Grade Math Word Problems Worksheets Pdf.


text:
Shane Warne To Auction His Baggy Green Cap To Raise Money For Bushfire Victims
Shane Warne, The Greatest Legspinner Ever From Australia, Has Decided To Auction His Baggy Green Australian Cap To Raise Money For The Bushfire Victims.
News Nation Bureau | Edited By : Siddharth Vishwanathan | Updated on: 06 Jan 2020, 11:28:20 AM
Shane Warne was the 350th Australian player to be handed the Australian Baggy Green during his debut in 1992. (Photo Credit: Shane Warne Facebook)
The Australian bushfires have ravaged the country and they are becoming intense with every single passing day. Celebrities and sporting personalities from across the spectrum in Australia have helped in every manner to raise funds for the victims of the bushfire menace that is plaguing predominantly East and South Australia. In the state of New South Wales and Victoria, there is a state-wide emergency imposed. Amidst all this, Shane Warne, the greatest legspinner in the history of cricket, has decided to contribute in his own way and his gesture is winning the internet.
Taking to his official Facebook page, Warne wrote, "The horrific bushfires in Australia have left us all in disbelief. The impact these devastating fires are having on so many people is unthinkable and has touched us all. Lives have been lost, homes have been destroyed and over 500 million animals have died too. Everyone is in this together and we continue to find ways to contribute and help on a daily basis. This has lead me to auction of my beloved baggy green cap (350) that I wore throughout my test career (when I wasn't wearing my white floppy hat). I hope my baggy green can raise some significant funds to help all those people that are in desperate need. Please go to the link in my bio and make a bid & help me to donate a big cheque ! Thankyou so much."
Please bid here https://t.co/kZMhGkmcxs pic.twitter.com/ZhpeWQxqY7
— Shane Warne (@ShaneWarne) January 6, 2020
Warne was the 350th Australian player to be given the Baggy Green but for most of his career, he wore the white floppy hat while playing. As a cricketer, Warne's exploits are nothing short of genuis, having taken 708 wickets and standing second in the all-time list of wicket-taker in Test matches behind Muttiah Muralitharan's tally of 800. The Australia bushfires have ravaged the country and it has left a massive trail of devastation behind. 18 people have died so far. David Warner, the Australian left-handed opening batsman, has expressed shock at the escalating horrors of bushfire that has gripped Australia and paid tributes to firefighters and volunteers who are trying their best to douse the devastating flames, terming them as the real heroes.
Also Read | Chris Lynn, Glenn Maxwell Announce Unique Initiative To Tackle Bushfire Menace, Wins The Internet
With heatwave expected to sweep across the country on Saturday, the umpires will take a call if the match needs to be suspended or delayed incase the smoke generating from the bushfire affects the air quality or visibility. Disturbed by the horrors of the deepening crisis, Warner shared a picture of a person with a dog watching the devastating forest fire. "I just saw this picture and I'm still in shock. When we go out to play tomorrow, not just the Australian team, but New Zealand as well, we never forget how privileged we are to live where we do and to do what we do. My heart, my family's hearts are with you. These fires are beyond words. To every firefighter, volunteer to every family, we are with you. You are the real heroes. You do us proud," Warner said on Instagram.
For all the Latest Sports News News, Cricket News News, Download News Nation Android and iOS Mobile Apps.
First Published : 06 Jan 2020, 11:28:20 AM
Shane Warne Baggy Green Australia Bushfires Bushfires Australia Vs New Zealand


text:
Kengyu, no folclore japonês, é o jovem amante da princesa Orihime. O casal é reverenciado durante a realização da festa japonesa Tanabata Matsuri.

Conta a lenda que, por dedicarem-se quase que somente à seu amor, os jovens foram transformados em estrelas e separados pela Via Láctea. Contudo, podem se encontrar uma vez ao ano, em Julho. É quando se dá o Festival das Estrelas, o Tanabata Matsuri.

Mitologia japonesa


Unless, of course, you've tinted the rear window and then you'll go through the joy of using a razor blade to scrape out the tint that exists between the defroster grid. Or, you'll have to just scrape off the defroster grid.
I think it depends on the region and enforcement of the scruts. I had tint on my 914 initially (when it was a daily driver), and i pulled off the rear window tint, but left it on on the side windows and the little wing windows. The side windows are down when on the track anyway, and no one has ever commented on the wing windows. Its like 15% too. 914 windows are mostly flat though, so easy to tint and untint. I think its easier for them to just say no aftermarket tint, then put in a % and try to measure it. There is enough hassles and specifics the scruts have to go through that actually are safety hazards.


(FT5) More E-M1 testing report .
1) While not official the E-M1 body price should be $1,500. There will be also two kit version with 12-40mm or 12-50mm lens.
3) True Pic VII processor improves video quality like moire reduction.
4) has mic Input, single SD card slot.
5) New Environmental Sensing System will adjust VF brightness automatically, according to scene.
7) The 12-40mm lens has a snap-manual ring – just like the 12 and 17mm!
The camera and lens will be announced on September 10 at 5-6 am London time!
previous post: Samyang 10mm f/2.8 for MFT and FT coming.


From Madison to Pensacola, Northwest Florida is home to one of the state's brightest and most promising economies, influenced by emerging industries, global investments, eco-friendly enterprise, new real estate offerings and leading-edge research and development.
Within our pages and on our website, the award-winning 850 – The Business Magazine of Northwest Florida is dedicated to telling the dynamic story of the region's exciting new role in state, national and international marketplaces. We do this through insightful features, in-depth spotlight stories on people, places and businesses and comprehensive articles on business trends and perspectives.
A team of handpicked business writers provides compelling stories that focus on the region's dazzling array of expertise and industries. 850 is the only publication dedicated to keeping a finger on the pulse of business in Northwest Florida.
Verifiable direct-mail distribution means that 850 reaches the decision makers in Northwest Florida. Our distribution puts your message at the fingertips of business leaders throughout the 18-county region.
For any additional inquiries, feel free to contact us.


text:
<--Notes-->

Another area which we have become consistent across projects on is tooling

All projects now use grunt as a task runner, jshint, csslint, htmllint, and for code quality,  and soon jscs for code style, and we use commitPlease for checking commit message formating


And I'm back from our trip to Melbourne! The main purpose of the trip was for my younger sister's wedding, of which I had the privilege of being the maid-of-honour (more accurately 'matron-of-honour', but this title makes me feel old). And what a wedding it was! Unfortunately I have very little photos on my camera due to being highly occupied with bridesmaid's duties, but I did make it a priority to take photos of the food to share on my blog. I don't usually blog about wedding food, but this was perhaps the best wedding food I've had. My sister said they chose The Red Scooter based on the reviews for the food, but everything else was also excellent. The staff ensured that the event flowed smoothly from before the start of the ceremony to after we bid farewell to the newlyweds at the end of the night. The venue itself was gorgeous, a great choice for a contemporary-style wedding. I loved the black and red colour scheme, which tied in very nicely with the wedding colours of storm grey and dark red. The ceremony was held in a small hall, and both the cocktail and reception dinner were held upstairs. The following two photos of the venue were taken on the day before the wedding when we were at The Red Scooter for the rehearsal.
The pre-dinner canapes served after the ceremony were delicious, and we enjoyed seven different types including crispy lemon chicken, Peking duck pancakes and ceviche of scallops with guacamole (my fave!). Unfortunately I have no photos of the canapes, so you'll just have to take my word for it.
A table was set up in the canapes area with a range of yummy desserts for the guests to help themselves to, and the venue called this 'Bakers Market'. These were so good!
You're welcome! The Red Scooter's staff who worked that night (wedding planners, DJ, lighting, waitstaff, chef and kitchen staff etc) are to be commended for the good job done!
Great event! Really nicely posted blog....Thanks for this valuable information.
Incredible wedding!! Really loved all food available here. The cake looks adorable too. Recently attended a wedding at one of New York wedding venues. There buffet table was prepared by catering service. It was very delicious. Planning to hire great services for my wedding too.
I was born in Malaysia, grew up in Perth (Australia), lived in Japan (where my firstborn was born) and Hong Kong (where my girls were born), and currently located Melbourne; I also have an obsession with food - hence the name Expat Gourmand. I love cooking AND eating, and am constantly on the lookout for new recipes to try out and great places to eat at. My journal is about my encounters with food - full of recipes I've tried and reviews of restaurants I've eaten at - as well as miscellaneous entries on travelling and life in general.
Copyright © 2005-2017 Expat Gourmand. Simple theme. Powered by Blogger.


Rain or shine. Free to sellers and shoppers alike! The parking lot will be filled with up to 100 dealers selling: dollhouses, kits, room boxes, furniture, accessories, books, collectibles, antiques, one-of-a-kind pieces, dolls and more. Register to sell, or just come to shop!
The Elegant Dollhouse and Barbara are featured on the back cover of this month's Miniature Collector. Congrats, Barbara!


text:
Q: Spinning ice skater and Coriolis force Among the explanations for the Coriolis force I've seen, there is a mention of the ice skater's rotational acceleration by pulling arms in radially.
I've always understood the spinning ice skater as conservation of angular momentum.  However, I do see that the Coriolis force cross product formulation of
$-2m\ \vec{\omega} \times \vec{v} $
(cross product of rotational velocity and the velocity of pulling the arm in) yields a vector that is tangential to the arm's spiral sweep and should cause rotational acceleration.
Can someone confirm that the rotating ice skater system is a satisfactory example of this?  I've already read through an analysis of forces in the inertial frame that is posted here, which seems pretty thorough but doesn't mention Coriolis so I'm not sure that my perspective is correct.

A: When the rotating skater pulls his arm in close to the body, his moment of inertia $I$ decreases. As the angular momentum $L=I\omega$, where $\omega$ is the angular velocity, is conserved, this means that the angular velocity $\omega$ has to increase so that $L$ stays the same. This has nothing to do with the Coriolis force.
Note: The Coriolis force is an apparent force that like the centrifugal force only appears in a rotational frame of reference. The Coriolis force is not seen in an inertial frame of an observer.

A: The rotational acceleration gained by a spinning ice skater can indeed be explained using the Coriolis force. Yes, there is no Coriolis pseudoforce in the inertial frame. However, the fact of the matter is that by contracting her arms, a sideways (tangential) force must somehow act on her body, for otherwise she cannot angularly accelerate. The question is, can this sideways force be explained from a fundamental viewpoint?
If we want to work directly in the inertial frame, we observe that
when the ice skater contracts her arms (along what she thinks are straight lines), they are actually traveling along curved paths. This requires a lateral force to be exerted on her arms, and if she exerts this lateral force herself (with her own body), then in the inertial frame, this must, by Newton's Third Law, induce a tangential counter-force on her body that rotationally accelerates her.
But now let's see what this implies in the rotational frame: Since a sideways force must be exerted to simply move the skater's arms in a straight line in this frame, this means there must be an opposing sideways pseudoforce that acts on any radially moving object in this frame. This pseudoforce cannot be the centrifugal force, since that only acts along the radial direction (and thus cannot push the skater's arms sideways). Thus, we conclude that there must be another pseudoforce apart from the centrifugal force in the rotating frame, and this must give any radially moving object a sideways push. This pseudoforce is precisely what we call the Coriolis force.
Thus, the rotational acceleration caused by the ice skater's contracting her arms can be legitimately attributed to the existence of a Coriolis pseudoforce in her rotating frame that she needs to counter to move her arms radially. Of course, since the same rotational acceleration can also be explained using conservation of angular momentum in the non-rotating frame, this shows that the Coriolis force and the conservation of angular momentum are intimately connected.

A: The Coriolis force is always directed perpendicular to the movement of a body. So, it doesn't exert any influence on the speed and kinetic energy of the ice skater (in fact, it could only change his direction). In other words, it does no work in this situation.
On the other hand, the force one has to apply a force inward to counter the centrifugal force does do a mechanical work: this is the work the ice skater has to do by his muscles in order to keep spinning (that is, the increase in rotation is a result of him pulling in his arms).
Any of this is in contradiction with the answer you referred to. The author of that answer didn't considered a non-inertial frame in his explanation, that's all.


text:
Impact For Patients: International Neonatal Consortium
Home>Impact For Patients: International Neonatal Consortium
INC's work has created a paradigm shift in clinical drug development for neonatal seizures.
A 2018 publication found over 96% of neonates receive at least one off-label medication while in the neonatal intensive care unit (NICU). Off-label medications are a normal part of patient care, however their use results in more adverse drug reactions in NICU patients. For medications to be used on-label, or to be indicated, for a specific patient population, they must first be rigorously studied in that population. Unfortunately, designing drug trials in neonates is extremely difficult.
The most accepted definition of a neonate is newborns through 27 days after term birth or 27 days after expected date of delivery for preterm newborns. Neonates show significant variability that is not present in other populations. For example, while both are considered neonates, a preemie may weigh as little as 1 pound, while a healthy full-term baby can weigh 10 pounds or more. A proportional difference from the average adult, weighing approximately 150 pounds, would weigh 1,500 pounds. A neonate's organs are also developing rapidly, so designing a trial that can assess a drug's physiological effects is inherently difficult. In the face of these and many other complexities, drug trials in neonatal populations have been near nonexistent.
With a shortage of controlled research to inform decisions, healthcare workers rely on personal or institutional experience to guide care. A lack of standardized language across the field contributes to a persistent gap in data that could otherwise be used to help inform care or translated to advance medical product development. Instead, most treatments in neonates are used off-label, exposing vulnerable patients to additional risks.
There is a persistent unmet need for safe and effective products specifically catered to and studied in neonatal populations.
In 2015, the Critical Path Institute (C-Path) launched its International Neonatal Consortium (INC), a global public-private partnership formed to forge a predictable regulatory pathway for evaluating the safety and efficacy of therapies for neonates. INC unites stakeholders from hospitals, research institutions, drug developers, patient advocacy groups, regulatory agencies and other organizations around the world to generate consensus and develop tools that accelerate medical innovation for neonates.
With its diverse group of stakeholders, INC works to curate input from parents, physicians, nurses, patient organizations and others across the field, generating broad consensus and guidelines that enhance clinician, researcher, drug developer and regulator decision making.
In 2018, INC and its partners collaborated to develop guidelines to inform the design of rigorous and efficient clinical trials for potential treatments of neonatal seizures. Neonatal seizures are the most common neurological emergency in neonates, occurring in approximately 3 in 1000 term live births, and are associated with significant mortality and neurodevelopmental disability. Trials for this condition are exceedingly difficult and face many challenges, including different diagnostic criteria in different countries, relative rarity in occurrence and the self-limiting nature of many neonatal seizures, which can make them difficult to capture in the setting of a controlled study.
Susan McCune, M.D., director of the Food and Drug Administration's (FDA) Office of Pediatric Therapeutics, described a situation where many companies had an interest in developing new or repurposing existing therapies to treat neonatal seizures, but struggled to design appropriate clinical trials.
As a result of INC's work, consensus recommendations were developed and published to address vital aspects of neonatal seizure clinical trials, including considerations for alternative designs, inclusion and exclusion criteria, safety monitoring, appropriate outcome measures, analytical plans and more.
The INC publication, Recommendations for the Design of Therapeutic Trials for Neonatal Seizures, directly facilitated FDA and other regulatory agency interactions with drug developers. According to Dr. McCune, drug developers now approach FDA with INC's publication in hand, discussing how they intend to execute clinical trials for this condition.
The publication has provided a roadmap for industry that previously didn't exist. Since it was published, several industry companies have reached out for more information on how they can begin designing clinical trials for neonatal seizures. Preliminary industry sponsored studies, intended to set the stage for future larger trials, have already begun. Despite being published less than two years ago, the field is already seeing transformative activity.
To date, INC's publication has been accessed more than 3,000 times. As INC's work spreads throughout the neonatal community, drug developers will have the resources they need to develop new medications specifically for neonatal patients. Clinicians will have more evidencebased treatment options for their patients, and patients will have better, safer and more effective therapies.
Photos feature Annie (1lb, 15oz) and Lucy (1Ib, 9oz) Beaumont
Photo credit: INC member Wakako Eklund
Critical Path Institute is supported by the Food and Drug Administration (FDA) of the Department of Health and Human Services (HHS) and is 55% funded by the FDA/HHS, totaling $17,612,250, and 45% funded by non-government source(s), totaling $14,203,111. The contents are those of the author(s) and do not necessarily represent the official views of, nor an endorsement by, FDA/HHS or the U.S. Government.