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The Meharry Translational Research Center
The purpose of the Meharry Clinical and Translational Research Center (MeTRC) grant is to cultivate minority researchers by funding their projects, and building an infrastructure of laboratories, training, and support staff. Budding scientists compete for pilot projects, in hopes their research ideas will mature into collaborative projects with other investigators. In time, they become fully funded researchers who are able to attract external funding and operate independently.
Translational research is a branch of scientific research that has developed in recent years which translates lab discoveries into actual treatments patients can use. The scientists in the Meharry Translational Research Center look for treatments for diseases and health disorders that disproportionately impact minorities. Areas of emphasis include infectious diseases (especially HIV/AIDS) and women's health.
REQUIREMENT: Each publication, press release, or other document about research supported by a National Institutes of Health (NIH) award must include an acknowledgment of NIH award support and a disclaimer such as:
"Research reported in this publication was supported by the National Institute on Minority Health and Health Disparities of the National Institutes of Health under Award Number U54 MD0007593. The content is solely the responsibility of the authors and does not necessarily represent the official views of the National Institutes of Health."
See Our Research Projects
METRC Key Activities
Biomedical informatics is an interdisciplinary science that integrates clinical research, biology, computer science, Health Information Technology (HIT), biostatistics, and mathematics to solve problems related to biomedical research. Biomedical informatics serves as the backbone that drives discovery from the bench to the bedside.
The success of our current biomedical informatics program capitalizes on Meharry's strong collaborative networks and alliances with regional and national research programs such as the Research Centers in Minority Institutes (RCMI), the RCMI Translational Research Network (RTRN), and the Clinical and Translational Science Award (CTSA). This allows biomedical informatics to leverage resources available through these programs, and to collaborate among biomedical informatics activities.
To fulfill these goals, the specific aims are as follows:
Develop an effective informatics infrastructure that will support the Meharry Clinical and Translational Research Center (MeTRC) goals in translational research;
Develop new informatics tools and enhance our existing tools to meet the program's demands for informatics support;
Develop strategies for facilitating internal communication within MeTRC as well as external collaboration and partnerships.
Supported by the National Institute On Minority Health And Health Disparities of the National Institutes of Health under Award Number U54 MD0007593.
Collaborations and Partnerships
The objective of the Collaborative Research Program (CRP) is to foster sustained collaborations between basic, clinical, and translational researchers from various disciplines at Meharry Medical College and to generate long-term partnerships with other public and private organizations in order to grow an integrative program of clinical and translational research.
Specific Aims are:
Develop a MeTRC-based Collaborative Research Program (CRP) to provide the financial resources to protect the time of clinical as well as basic researchers to participate in large-scale collaborative translational research projects related to disparities in women's health and infectious disease.
Increase external and internal partnerships to accelerate the success and national impact of research at Meharry Medical College. Develop a sustained, evidence-based translational research network in Tennessee that partners Meharry with the State of Tennessee Department of Health (in particular, the Tennessee Division of Minority Health and Health Disparities Elimination) along with other academic and community health centers and agencies to address health disparities related to women and infectious disease. The network will design and implement a much-needed regional or state-wide intervention on a community health concern to be determined by the network. Promote collaborations within Meharry among basic and clinical scientists, and between departments and schools to launch new translational research projects. Develop collaboration(s) between Meharry and the Resources for Translational Research Network (RTRN) as well as the Data Technology Coordinating Center (DTCC), while maintaining our focused partnerships with Vanderbilt Medical Center's Clinical and Translational Science Award (CTSA) program, which has been dubbed Vanderbilt Institute for Clinical and Translational Research (VICTR).
Development of an interactive MeTRC website to share information about research-related activities with collaborators, RTRN and VICTR
investigators and the public.
Stella Nowicki, D.D.S.
Collaborative Research Program Director
snowicki@mmc.edu
Community Based Research
The goal of the Community Engagement and Research Program (CERP) within Vanderbilt's Institute for Clinical and Translational Research (VICTR) program is to develop transformative collaborative structures and strategies that will bring Meharry Medical College (MMC) and Vanderbilt University (VU) translational investigators and research programs together with community partners to shape and support innovative and community-based research. CERP provides the necessary opportunities, and broadly engages community partners throughout the clinical and translational research enterprise. The proposed program will build on existing activities and structures to create an explicit and innovative infrastructure that will engage community partners, including:
Academic institutions;
Health care systems, providers and payers;
Corporate healthcare entities, and;
Community advocates including public health entities, non-profit and faith-based organizations, and grass-roots groups that focus on improving community health.
The proposed program will engage each of these groups of partners to develop meaningful working relationships and stimulate and support collaborative translational research.
To create and sustain an effective infrastructure that brings community and academic partners together to design, implement, evaluate and disseminate health-related research studies that enhance the capacity of all participants to address health priorities among diverse communities.
To engage community and academic partners to increase the quality and quantity of effective, responsive, and culturally- sensitive translational research that result in the implementation of best practices to improve public health.
To develop a set of core services that will support the efforts of researchers in the planning, implementation, and evaluation of research projects that engage communities, including:
Community data profiling and needs assessment;
Process evaluation of community-based research;
Development and maintenance of a web-based community and academic resource registry
Community engagement and capacity building consultation;
Measurement and outcomes evaluation consultation;
Training and education services;
Dissemination and utilization services.
Leah Alexander, Ph.D.
Community Engagement and Research Program Director
lalexander@mmc.edu
The focus of the Meharry Translational Research Center (MeTRC) evaluation activity is to conduct monitoring evaluation, mid-term reviews and periodic surveys with key stakeholders in order to ensure that there is robust evidence and a knowledge base for the design, implementation and impact assessment of the key functions. Additionally, the key functions are evaluated based on their collective effects on building capacity and infrastructure for clinical and translational research in women and health disparities.
On-going monitoring and evaluation facilitates the day to day management of the program. The mid-term review conducted at the end of year two is intended to illuminate the steps required to achieve desired goals. An external evaluator is expected to conduct a summative evaluation during the final year of the initiative to assess as objectively as possible the extent to which MeTRC met its short- and long-term objectives. Overall, the evaluation plan will generate evidence on the impact of MeTRC on building capacity and infrastructure for clinical and translational research, and examine related questions such as whether capacity for competitive clinical and translational research in women health disparities is increasing and what pathways led to the increase. Evaluation findings will provide critical information for guiding MeTRC as well as the future planning of Clinical and Translational Research (RCTR) programs.
Christine Minja-Trupin Ph.D.
MeTRC Evaluation Director
ctrupin@mmc.edu
Participant & Clinical Interaction Resource
The purpose of the Participant and Clinical Interaction Resource (PCIR) is to provide the resources necessary to facilitate clinical research in a minority academic setting by expanding existing programs, nurturing new investigators, and encouraging full utilization of its services. This PCIR provides an environment that promotes participation in outpatient clinical and translational research, community outreach that fosters participation of underrepresented minorities, and resources for cost-effective research participant interactions.
Specific Aims:
Specific Aim 1: Enhance institutional and translational research infrastructure, capacity, and accountability;
Specific Aim 2: Provide an outpatient clinical and translational research environment that fosters the participation of underrepresented minorities;
Specific Aim 3: Foster intra-institutional and inter-institutional collaborations to increase the capacity to improve minority health and address minority health disparities.
The purpose of the Meharry Translational Research Center (MeTRC) Pilot Project Program is to fund peer reviewed investigator-initiated pilot projects in translational and clinical research which will develop, energize, and maintain a critical mass of clinical and translational scientists at Meharry Medical College.
The specific aim of the program is to increase the quantity and quality of translational and clinical research projects at Meharry Medical College and enhance the competitiveness of Meharry's clinical and translational research investigators in securing extramural research funding.
We are able to achieve this specific aim by developing and disseminating internal Requests for Applications (RFA), soliciting for pilot investigator-initiated translational and clinical research projects.
One major impediment to translational and clinical research is the difficulty in determining whether the idea has any real merit once applied to the human model. Frequently this preliminary evaluation lends itself to the format of a pilot project. Furthermore, most National Institutes of Health (NIH) grant application mechanisms generally require some, if not substantial, preliminary data in order to compete and receive serious consideration.
Such data can be generated via seed or pilot project funding program without the major time and fund investment in a full project, and without exposing research subjects to unnecessary long and potentially risky clinical trials.
For a listing of current and previous Pilot Projects click here.
Bogdan Nowicki, M.D.
MeTRC Pilot Projects Director
bnowicki@mmc.edu
The overall objective of the faculty recruitment program is to attract investigators that will further the development of Meharry's capacity to conduct clinical and translational research.
Specific Objectives of the program are:
To establish a cadre of investigators engaged in sustained, independent clinical research who will serve as career models and mentors for developing clinical and translational scientists at Meharry.
To provide skilled leadership for the Clinical Research Center which will enable the unit to offer proactive, robust, and efficient services for clinical and translational research related to health disparities.
The faculty recruitment program is relevant to public health because it will increase the number of scientists at Meharry who are conducting research that directly involves patients. In addition, because the research focus of Meharry is health disparities, the faculty recruitment program will specifically focus on investigators that understand the myriad of reasons for the striking differences in the health status of different sectors of the American public, and will focus on ways to eliminate these disparities.
The faculty recruitment program intends to recruit a magnet physician-investigator and a second physician-scientist who, together with current faculty, will furnish a model of clinical science as a primary career commitment. The investigators who are recruited will be expected to demonstrate specific methods of implementing translation research for the junior faculty members. They will be serving as mentors for the junior faculty members and will be utilizing various methods of communications, to lead by way of example. As part of this endeavor, the magnet scientist will be expected to "take charge" of the Clinical Research Center, and use it as an instrument to develop junior investigators into independent, career scientists as well as to deepen our understanding of human health.
Russell E. Poland, Ph.D
Director of Recruitment
rpoland@mmc.edu
Regulatory Knowledge and Support
The overall vision of the Meharry Translational Research Center (MeTRC) Regulatory Support Core is to provide regulatory knowledge and support through a process of standardization and consistent implementation of advances in information technology /services to all investigators and clinical research personnel. Our mission is to reduce their administrative burden and improve participant safety and regulatory compliance in an effort to foster translational research and expedite the speed with which findings are translated to patient care. This vision involves improved quality.
As a result, documents will be submitted to the Institutional Review Board (IRB) and other administrative offices in a higher quality form resulting in fewer steps/delays in approval and less frustration from investigators. Streamlined communications, standardized processes, forms, templates and staff with knowledge of regulatory and reporting requirements will result in improved efficiency and satisfaction.
The Specific Aims of the Regulatory Core are:
Guided by data-driven needs assessments, the Vanderbilt Institute for Clinical and Translational Research (VICTR) will provide a "One-Stop Shopping Environment" in support of the research community by adding in an expanded menu of services. This includes:
Improve regulatory compliance and protection of human subjects by expanding Individualized Measured Performance and Collaborative
Training Techniques (IMPACTT);
Help researchers navigate the process by creating a central point of access to research resources;
Design and coordinate efforts to provide access to educational tools, resources and sessions designed for investigators and research personnel;
Improve communication and identification of regulatory, compliance or process issues.
Support new investigators by creating an Investigator Advocacy Program to provide a specialized set of research services consultants assisting with some or all components of the regulatory administrative efforts and serve as a liaison in interactions with IRB and other regulatory bodies of internal administrative offices. Investigators and clinical study personnel represented by the Investigator Advocate (IA) will bear less of the burden of administrative regulatory requirements thereby allowing investigators and research personnel to focus on participant interactions, safety and most importantly, their scientific interests.
Ensure research subject safety and knowledge, as well as research integrity and quality by expanding the Research Subject Advocacy (RSA) Program to help ensure human subject protection.
Support "big science" by implementing our Professional Management Program, staffed with personnel trained to move teams toward a common vision on complex, multi-disciplinary projects.
Russell Poland
Regulatory Support Director, MeTRC
Jared Elzey
Project Manager of the Meharry Research Concierge Services (MeRCury)
jelzey@mmc.edu
Yaritza Griselle Gandulla
Investigator Advocate, Research Immediate Office
ygandulla@mmc.edu
Research Design, Biostatistics and Clinical Research Ethics (DBRE)
The speed at which translational research impacts population health depends heavily on whether the work is disseminated and incorporated by clinical or health service efforts.
In turn, dissemination and incorporation efforts are influenced by the appropriateness and accuracy of the research design and analysis, as well the degree to which implementation is ethically sound.
Therefore, our mission is to develop and provide strong support in research design, biostatistics, and clinical research ethics for Meharry translational research investigators.
Our Specific Aims are:
Specific Aim 1: Strengthen all aspects of translational research design, biostatistical analysis, and clinical research ethics through consultations
Specific Aim 2: Provide key seminars related to translational research design, biostatistics, and clinical research ethics
Technologies and Resources for Core Laboratories
The mission of the Meharry Technologies and Resources for Core Laboratories is to provide services, computer resources, support, and training both inside and outside of the Meharry research community. Our goal is to ensure that all interested scientists are able to access and utilize state-of-the-art technologies for Protoemics, Mass Spectrometry, Imaging Analysis, Bioinformatics, and other data intensive applications. We strive to keep our facility up to date computationally and intellectually with services to support education and research in proteomics, bioinformatics, computational biology, and systems biology.
Our goals are to serve a broad research community and significantly enhance translational and clinical research at Meharry Medical College. We are committed to developing novel diagnostics and therapeutic interventions.
The Specific Aims of the Technologies and Resources for Core Laboratories are:
To develop a Proteomics Core Facility to expand and support Meharry's clinical and translational research activitiesTo develop collaborations and partnerships inside and outside of Meharry Medical College that accelerates clinical and translational research, with the common link being the reliance on state-of-the-art proteomics strategies.
Supported by the National Institute on Minority Health And Health Disparities (NIMHD) of the National Institutes of Health (NIH) under Award Number U54 MD0007593
Evaluation and Program Components
Partnerships/RCMI R-Centers
METRC Conference Abstracts
Recent Scientific Highlights
The Meharry Clinical and Translational Research Center (MeTRC) grant funds two of Meharry's core facilities, the Participant and Clinical Interaction Resource and the Meharry Proteomics Core.
The Participant and Clinical Interaction Resource
The Participant and Clinical Interaction Resource, known as PCIR, helps researchers execute their clinical studies. Conducting clinical trials is beyond the scope of most grants; however, the PCIR helps scientists design their studies, locate research subjects, conduct their studies, collect samples, and submit documentation. A specially certified nursing staff who are knowledgeable about researchers' protocols carry studies to their conclusion.
The Meharry Proteomics Core
Our Proteomics Core aids investigators and trainees with high performance computation in proteomics, as well as other "omics" type applications needing efficient analysis of large-scale biological data sets. The ability to incorporate proteomics into translational and clinical biomedical research is critical for the discovery of therapeutic interventions and high fidelity biomarkers of disease and response to therapy. The Proteomics Core provides state-of-the-art services, training, and bioinformatics-driven data analysis to the Meharry translational research community.
The Meharry Translational Research Center (MeTRC) and the Vanderbilt Institute for Clinical and Translational Research (VICTR) have united to offer research expertise to the community. The Meharry-Vanderbilt Community Engaged Research Core (CERC) builds partnerships and adds the scientific element to community work groups. Through workshops/training, consultation, mini-grants, educational material, and use of core facilities, the CERC is working one-on-one with communities to improve citizen health and broaden neighbors' health knowledge. For more information, contact the CERC at 615.936.2565 or cerc@vanderbilt.edu.
The goal of MeTRC is to reduce investigators' administrative burden and improve participant safety and regulatory compliance through process standardization, information technology, and other services to investigators and clinical research personnel. In partnership with VICTR, MeTRC has made available to researchers a knowledge base of regulatory matters and created a one-stop-shop (the StarBRITE tool) that helps them navigate through complex, interdisciplinary projects. It has also enhanced Meharry's clinical research function with the patient advocacy and experiment-design functions now available in the Participant and Clinical Interaction Resource (PCIR). If you have questions about regulatory support at Meharry, contact PCIR at 615.327.5725.
Research Design Ethics
In tandem with the Office of Participant and Clinical Interaction Resource, MeTRC makes available to researchers the expertise of CITI-trained clinical research staff, and investigators at Meharry, both newcomers and seasoned professionals, will find time- and labor-saving guidance in the creation of their clinical trials. Contact the PCIR at 615.327.5725 for assistance.
As medicine has evolved from stethoscopes to PET scans, laboratory research has evolved from test tubes to fluorescent microsopy. The sophistication of today's research environment is therefore narrowly competitive. MeTRC research projects are therefore narrowly examined for competitive advantage. Using rigorous study design and a refined logic model that incorporates multiple data collection points, MeTRC assesses projects' indicators, milestones, tools and study design, key function reports, and more. Successful grants beget yet more grants; MeTRC's evaluation function crosses the T's and dots the I's so that researchers are knowledgeable, projects are effective, and research translates to cures.
RCMI R-Centers
Meharry Translational Research Center (MeTRC)
Website: Meharry Translational Research Center (MeTRC)
RCMI Multidisciplinary And Translational Research Infrastructure eXpansion (RMATRIX)
Website: https://rmatrix.jabsom.hawaii.edu
Charles Drew University
Accelerating Excellence in Science (AXIS)
Website: https://www.drew-axis.org
Morehouse School of Medicine
RCMI Center of Excellence for Clinical and Translational Research (RCTR)
Website: https://www.msm.edu
Puerto Rico Clinical and Translational Research Consortium (PRCTRC)
Website: https://prctrc.rcm.upr.edu
The following newsletters are from the RCMI Research Centers in Minority Institutions (RCMI) Infrastructure for Clinical and Translational Research (RCTR) Newsletter
RCTR Collaboration Volume 3 Number 1 (October 23, 2013): RCTR Collaboration newsletter in PDF format.
Collaboration_v3_n1.pdf
RCTR Collaboration Volume 2 Number 2 (November 1, 2012): Eighth issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
RCTR Collaboration Volume 2 Number 1 (July 1, 2012): Seventh issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
RCTR Collaboration Volume 1 Number 6 (May 1, 2012): Sixth issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
RCTR Collaboration Volume 1 Number 5 (February 13, 2012): Fifth issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
RCTR Collaboration Volume 1 Number 4 (November 1, 2011): Fourth issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
RCTR Collaboration Volume 1 Number 3 (September 1, 2011): Third issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
Collaboration_v1_n3.pdf (size: 3145664 bytes)
RCTR Collaboration Volume 1 Number 2 (July 1, 2011): Second issue of a newsletter focused on accomplishments by NCRR RCTR awardee institutions.
Collaboration_v1_n2.pdf (size: 11470313 bytes)
RCTR Collaboration Volume 1 Number 1 (May 1, 2011): First issue of a new newsletter focused on accomplishments by NCRR RCTR awardee institutions.
[1] S. T. Pellom Jr., D. F. Dudimah, and A. Shanker
"Effects of bortezomib administration on cytokine secretion, signaling, and function in breast cancer"
Presented at the 6th Annual AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA, 2013
[2] D. F. Dudimah, R. V. Uzhachenko, A. Biktasova, D. P. Carbone, M. M. Dikov, and A. Shanker
"Cancer Therapy by Resuscitating Immune Surveillance"
Presented at the 6th Annual AACR Conference on The Science of Cancer Health Disparities in Racial/Ethnic Minorities and the Medically Underserved, Atlanta, GA 2013
[3] A. Shanker, D. F. Dudimah, R. V. Uzhachenko, A. Biktasova, D. P. Carbone, and M. M. Dikov
"Cancer Therapy by Restoration of Immune Notch"
Presented at the Society for Immunotherapy of Cancer Annual Meeting, National Harbor, MD, 2013
[4] A. Shanker
Presented at the Immunology Summit 2013, Las Vegas, NV, 2013
[5] A. Sakwe
"Profiling of genes associated with sustained high calcium adaptation of invasive breast cancer cells"
Presented at the Third AACR International Conference on Frontiers in Basic Cancer Research, National Harbor, MD, 2013
[6] D. J. Alcendor
"Racial Disparities in Bacterial Vaginosis and Associated Risks for HIV-1 Acquisition"
Presented at the 2013 United States Conference on AIDS, New Orleans, LA, 2013
[7] P. N. Nde, C. A. Johnson, Y. Y. Kleshchenko, O. A. Ikejiani, A. N. Udoko, T. C. Cardenas, S. Pratap, M. A. Duquette, M. F. Lima, J. Lawler, and F. Villalta
"The role of TSP1 in T. cruzi infection"
Presented at the Science Research Conference: Matricellular Proteins in Development, Health, and Disease, Saxtons River, Vermont, 2013
[8] V. Pensabene, D. Alcendor, D. Janigro, J. Sung, V. Allwardt, P. Schaffer, P. Samson, S. Crowder, C. Ghosh, N. Marchi, M. Deblock, K. Kopin, and J. Wikswo
"How to create a selective permeable blood-brain barrier (BBB) in a neurovascular unit-on-a-chip"
Presented at the DARPA/NCATS Microphysiological Systems Investigators Meeting, Cleveland Clinic Foundation, Arlington, Virginia, 2013
[9] T. Rana, R. J. Hasan, S. Nowicki, M. S. Venkatarajan, R. Singh, P. T. Urvil, V. Popov, W. A. Braun, W. Popik, J. S. Goodwin, and B. J. Nowicki
"Complement Protective Epitopes and CD55-Microtubule Complexes Facilitate the Invasion and Intracellular Persistence of Uropathogenic E. coli"
Presented at the Clinical and Scientific Advances in Urinary Tract Infections Conference, International Symposium, The Research Institute at Nationwide Children's Hospital, 2013
[10] S. Nowicki, T. Rana, R. Singh, and B. Nowicki
"Glucocorticoid as a new therapeutic approach against invasive Dr + E. coli causing chronic pyelonephritis"
[11] C. Wang, C. Timmons, H. Liu, and B. Liu
"GB Virus Type C E2 Protein Interferes with HIV-1 Gag Plasma Membrane Targeting Through Inducing ADP-Ribosylation Factors 1 Degradation"
Presented at the Structural Biology Related to HIV/AIDS, Bethesda, MD, 2013
[12] W. Popik
"APOL1 restricts HIV-1 by stimulating endocytic trafficking and targeting HIV-1 Gag for lysosomal degradation"
Presented at the CSHL Retroviruses Meeting, Cold Spring Harbor, NY, 2013
[13] T. Nayyar, F. Alam, W. Richie, T. Ansah, and R. Bailey
"Reduction in peripheral blood beta arrestin1 levels during major depressive disorder in reproductive women"
Presented at the Experimental Biology Conference, Boston, MA., 2013
[14] A. C. Johnson, Y. Y. Kleshchenko, O. A. Ikejiani, A. N. Udoko, T. C. Cardenas, S. Pratap, M. A. Duquette, M. F. Lima, J. Lawler, F. Villalta, and P. N. Nde
"Trypanosoma cruzi surface calreticulin interacts with host thrombospondin-1 to enhance cellular infection"
Presented at the Tenth Calreticulin Workshop, Banff, Alberta, Canada, 2013
[15] D. F. Dudimah, R. V. Uzhachenko, S. T. Pellom Jr., A. Biktasova, M. M. Dikov, D. P. Carbone, and A. Shanker
"Resuscitating Immune Surveillance in Cancer"
Presented at the AACR annual Conference, Washington DC, 2013
[16] S. T. Pellom Jr., D. F. Dudimah, R. V. Uzhachenko, and A. Shanker
"Defining the effects of bortezomib on tumor microenvironment"
Presented at Meharry Medical College Student Research Day – 2013
[17] C. Ghosh, N. Marchi, J. Wikswo, M. Deblock, D. J. Alcendor, and D. Janigro "Humans on-a-Chip, Optimization of the Human Neurovascular Unit In Vitro Model"
[18] R. V. Uzhachenko and A. Shanker
"T cell-dependent mitochondrial activity of anti-tumor NK cells"
Presented at the Annual Meharry- Vanderbilt- Tennessee State University (MVT) Cancer Partnership Retreat, Nashville, TN, 2013
"Bortezomib modulates cytokine/chemokine profile in tumor microenvironment" Presented at the Annual Meharry- Vanderbilt- Tennessee State University (MVT) Cancer Partnership Retreat, Nashville, TN, 2013
[21] P. D. Thompson, A. Sakwe, J. Ochieng, S. Pratap, and D. R. Marshall
"The α2-HeremansSchmid glycoprotein (AHSG) promotes growth in head and neck squamous cell carcinoma (HNSCC)"
Conference Paper in BMC Bioinformatics, 2013, vol. 14, p. A7
[22] S. Nowicki, R. Goldblum, J. Mestechy, J. Bienenstock, M. Lamm, L. Mayer, J. McGhee, and W. Strober
"Amniotic Fluid and the Fetal Mucosal Immune System"
Book Section in Muscosal Immunology, 2013
[23] D. Marshall, S. Pratap, J. Dong, G. Rogers, and L. Dent
"Genomic and proteomic characterization of multi-drug resistant Acinetobacter baumannii"
Conference Paper in BMC Bioinformatics, 2013, vol. 14, p. A22
[24] A. Addai, J. Pandhare, C. Mantri, and C. Dash
"Cocaine enhances HIV-1 integration in CD4+ T cells by altering the epigenetic DNA signatures"
Presented at the Annual American Society of Hematology (ASH) Conference, San Diego, CA, 2013
Presented at the Annual Meeting of Society for Neuroimmunopharmacology, San Juan, Puerto Rico, 2013
[26] S. J. Goodwin, T. Patel, and H. Khoshbouei
"Psychostimulants affect the dopamine transporter lateral mobility and membrane microdomain distribution"
Presented at the 13th RCMI International Symposium on Health Disparities, San Juan, Puerto Rico, 2012
[27] T. Nayyar, K. Golden, W. Richie, T. Ansah, and R. Bailey
"Beta arrestin-1 levels in leukocytes and depression in women"
[28] A. R. Chaudhry, W. Khoder, A. Small, S. M. Knobel, and D. J. Alcendor "Vaginal epithelium extracellular matrix expression profiles from women of diverse ethnicity with pelvic organ prolapse: implications for racial disparities in POP"
Presented at the 13th RCMI International Symposium on Health Disparities, Center for AIDS Health Disparities Research and the Department of Microbiology and Immunology, Hubbard Hospital, 2012
[29] D. Robertson, J. Southerland, and R. Davis
"Impairment of Vascular Nitric Oxide in African-AmericanWomen"
[30] T. Rana, S. Nowicki, R. Singh, and B. Nowicki
"Novel strategy for the non-antibiotic treatment of persistant intracellular infection: microtubule depolymerizing agents eliminate intracellular E. coli"
[31] M. G. Izban, B. J. Nowicki, and S. Nowicki
"Vitamin D3 promotes NF-κB-dependent expression of CD55 in monocytes"
[32] A. Hendy, A. Venkateswaram, R. S. Konjeti, G. Reddy, and G. Haddad
"Role of Estradiol-17beta and Vitamin D in Vascular Nitric Oxide Synthase and CGRP Receptor Expression"
[33] A. Shanker and R. V. Uzhachenko
"T Cell-dependent Anti-tumor Activity of NK Cells"
Presented as a Conference Paper at Society for Immunotherapy Annual Meeting, Washington DC, 2012, vol. 35, p. 759
[34] S. Pratap, M. T. Perry, N. Boukli, I. Almeida, T. Dye, S. Garner, and M. Powell
"Creation Of A Proteomics and Informatics Collaborative Group to Enhance Biomedical Research at Ethnically Diverse Institutions"
[35] S. Pratap, D. R. Marshall, and L. Dent
"Comparative Genomics of Multi-Drug Resistant Acinetobacter Baumanii at Nashville General Hospital @ Meharry Medical College"
Presented at the 12th Annual Host-Tumor Interactions Program & Department of Cancer Biology Retreat, Vanderbilt University, Nashville, 2012
Presented at the 42nd Annual meeting of the Autumn Immunology Conference, Chicago, IL, 2012
[40] S. J. Goodwin, S. Kustuv, T. Patel, and H. Khoshbouei
"Unlike amphetamine-exposed transporter the methamphetamine exposed transporter is fully responsive to consecutive drug application"
Presented at the 45th Annual Meeting for the Society for Neuroscience, New Orleans, LA, 2012
[42] A. C. Johnson, Y. Y. Kleshchenko, O. A. Ikejiani, T. C. Cardenas, S. Pratap, M. A. Duquette, M. F. Lima, J. Lawler, F. Villalta, and P. N. Nde
"Thrombospondin-1 interacts with Trypanosoma cruzi surface protein to enhance cellular infection"
Presented at the American Society for Matrix Biology & American Society for Glycobiology Meeting, San Diego, 2012
"Resuscitating cancer immunosurveillance by combining Notch 1 and death receptor activating therapy"
Presented at the Fifth AACR Conference on The Science of Cancer Health Disparities, San Diego, CA, 2012
[44] M. Hall, S. M. Knobel, A. R. Chaudhry, and D. J. Alcendor
"The effects of BV bacteria on vaginal epithelium HIV infectivity: Implications for mechanisms linked to health disparities in HIV/AIDS"
Presented at the Vanderbilt Vascular Biology Retreat: Training Grant in Mechanisms of Vascular Disease, Joelton, TN, 2012
[45] D. J. Alcendor, I. Wilkerson, S. M. Knobel, and N. Sheibani
"Retinal Pericytes and Cytomegalovirus Infectivity: Implications for both CMV Induced Retinopathy and Congenital Ocular Disease"
[46] A. R. Chaudhry, A. Small, S. M. Knobel, W. Khoder, G. Ladson, G. Richard-Davis, and D. J. Alcendor
"Vaginal epithelium extra-cellular matrix expression profiles from women of diverse ethnicity with pelvic organ prolapse: Implications for racial Disparities in POP"
Presented at the American Urogynecological Society (AUGS) 33rd Annual Scientific meeting, Chicago, IL, 2012
[47] L. Ricks-Santi, T. Dye, Z. Hammatt, and S. Pratap
"Sharing a Model Consent Form to Increase Enrollment of Ethnically Diverse Populations in Research and Biospecimen Repositories"
Conference Paper in Biopreservation and Biobanking, 2012, vol. 10, pp. 297–331
[48] A. Shanker, A. Malhotra, M. M. Dikov, A. Biktasova, T. J. Sayers, and D. P. Carbone
"Enhancing cancer immunotherapy by combining Notch 1 and death receptor activation"
Presented as a Conference Paper in the Journal of Immunology, 2012, vol. 188:46.38
"Potent inhibition of HIV-1 biogenesis by apolipoprotein L1"
[50] A. Sakwe, R. Koumangoye, and J. Ochieng
"Sustained hypercalcemia primes non-invasive breast cancer cells for metastasis to high calcium microenvironments"
Presented at the Experimental Biology Annual Meeting, San Diego, CA, 2012
[51] R. Singh, T. Rana, B. Nowicki, and S. Nowicki
"Glucocorticoid And CD55: Missing Link Between Stress And Infertility" Presented at the 9th Annual James Research Symposium, Meharry Medical College, Nashville, TN, 2012
[52] A. C. Johnson, Y. Y. Kleshchenko, O. A. Ikejiani, T. C. Cardenas, S. Pratap, M. A. Duquette, M. F. Lima, J. Lawler, F. Villalta, and P. N. Nde "Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular invasion"
Presented at the American Society for Biochemistry and Molecular Biology at Experimental Biology (ASBMB), San Diego CA, 2012
Presented at the International Conference on Advances in Biological Sciences: Session on Advances in Medical Biotechnology, Department of Biotechnology and Microbiology, Kannur University, 2012
[54] C. Timmons, Q. Shao, C. Wang, H. Wei, H. Liu, and B. Liu
"The Expression of GBV-C Envelope E2 Protein Inhibits HIV-1 Assembly and Release"
Presented at the 19th Conference on Retroviruses and Opportunistic Infectious, Seattle, WA, 2012
"Chronic Pyelonephritis in Pregnancy: Intracellular Survival and Persistence of the Gestational Pathogen Dr+ E. coli."
Presented at the Society for Gynecologic Investigation (SGI) Annual Scientific Meeting, 2012
[56] A. Shanker
"Lymphocyte Teamwork in Tumor Rejection," in Prospects in Bioscience: Addressing the Issues, A. Sabu and A. Augustine, Eds. India: Springer India, 2012, pp. 411–413
"Identification of CD55 Residues that Facilitate Invasion & Intracellular Persistance of the Gestational Pathogen Dr+ E. coli."
Presented at the 9th Annual James Research Symposium, Meharry Medical College, Nashville, TN, 2012
[58] M. Powell, N. Boukli, I. Almeida, T. Perry, T. Dye, and S. Pratap
"Creation of a Proteomics and Informatics Collaborative Group to Enhance Biomedical Research at Ethnically Diverse Institutions: ABRF"
Presented as a Conference Paper in the Journal of Biomolecular Techniques, 2012, vol. 23, pp. s51–s52
[59] D. Marshall, J. Dong, L. Dent, and S. Pratap
"The antibiotic resistance proteome of Acinetobacter baumanii MDR isolate MMC#4"
Presented as a Conference Paper in BMC Bioinformatics, 2012, vol. 13, p. A20
[60] C. A. Johnson, A. N. Udoko, T. C. Cardenas, S. Pratap, C. Taylor, G. Rachackonda, M. F. Lima, J. Lawler, F. Villalta, and P. N. Nde
"Trypanosoma cruzi induces fibrotic genes early in heart cells"
"Thrombospondin-1 interacts with Trypanosoma cruzi surface calreticulin to enhance cellular invasion"
Presented at the Experimental Biology Meeting, 2012
[62] S. Akohoue
"Improving Diabetes Self-Management in Low-Income Women: Preliminary Results from a Pilot Study"
Presented at the 2012 Science of Eliminating Health Disparities Summit, National Harbor, MD, 2012
[63] A. Addai and C. Dash
"Proteomics analysis of HIV-1 preintegration complexes"
Presented at the 53rd Annual American Society of Hematology (ASH) conference, San Diego, California, 2012
[64] S. Nowicki, T. Rana, R. Singh, and B. J. Nowicki
"Dexametasone down-regulates DAF and decrease intracellular survival of Dr+ E. coli."
Presented at the 5th International Complement Therapeutics Conference, Greece, 2011
[65] B. J. Nowicki, T. Rana, R. Singh, and S. Nowicki
"Identification of DAF Residues which facilitate intracellular multiplication of Dr+ E. coli."
Presented at the 5th International Complement Therapeutics Conference, Rhodes, Greece, 2011
[66] S. Nowicki, R. Singh, T. Rana, K. Osteen, B. Jarnagin, and B. Nowicki "Glucocorticoid and CD55: Missing Link between Stress and Infertility"
Presented at the 1st Congress for Gynecology and Fertility-Israel-Poland (GOFIP), 2011
[67] B. Nowicki, E. Pawelczyk, M. G. Izban, S. Pratap, and S. Nowicki
"Preterm Labor is Associated with an Increase in the Proinflammatory Signal Transducer TLR4 Receptor on Maternal Blood Monocytes-Novel Diagnostic Test" Presented at the 1st Congress for Gynecology and Fertility-Israel-Poland (GOFIP), 2011
[68] B. Nowicki, K. Wroblewska-Seniuk, C. Yallam, C. Le Bouguénec, and S. Nowicki
"The role of nitric oxide in intrauterine gestational infection caused by Dr/Afa positive E. coli."
Presented at the 1st Congress for Gynecology and Fertility Israel-Poland (GOFIP), 2011
[69] S. Nowicki, S. Pratap, M. G. Izban, and B. Nowicki
"CD55 in Maternal Blood Monocytes as a Molecular Predictor for Preterm Labor and Delivery"
Presented at the International Infectious Diseases Society for Obstetrics and Gynecology-USA (IIDSOG-USA), Weill Cornell Medical College, NY, 2011
"Dopamine transporter recruits alpha-synuclein to the plasma membrane and cotrafficks"
Presented at the Experimental Biology, Washington, DC, 2011
[71] C. Timmons and B. Liu
"GBV-C Envelope Glcoprotein E2 Inhibits HIV-1 Assembly"
Presented at the 1st UTEP Symposium Infectious Diseases and Health Disparities in a Changing World, 2011
[72] L. Dent, N. Ismail, S. Robinson, G. Rogers, S. Pratap, and D. Marshall "Next-gen sequencing of multi-drug resistant Acinetobacter baumanii at Nashville General Hospital at Meharry"
Presented Conference Paper in BMC Bioinformatics, 2011, vol. 12 suppl 7, p. A14
"Proteomics analysis of HIV-1 preintegration complexes. MMC Research Day 2011"
Presented at the Research Day Presentation, Meharry Medical College, Nashville, TN, 2011
Presented at the Meharry Translation Research Center Open House, Meharry Medical College, Nashville, TN, 2011
[75] D. J. Alcendor, C. N. Marrs, S. M. Knobel, S. D. Sweet, W. Q. Zhu, and A. R. Chaudhry
"Racial disparities in bacterial vaginosis and its influence on HIV-1 acquisition" Presented at the 10th RCMI International Symposium on Health Disparities, "Bridging the Gap between Disparity and Equity: New Minds — New Methods" Nashville, TN, 2010
[76] D. J. Alcendor, A. M. Charest, S. M. Knobel, and Q. W. Zhu
"Infection and upregulation of proinflammatory cytokines in brain vascular pericytes by human cytomegalovirus"
Presented at the 10th RCMI International Symposium on Health Disparities, "Bridging the Gap between Disparity and Equity: New Minds — New Methods" Nashville, TN, 2010
"GBV-C E2 Inhibits HIV-1 Assembly"
Presented at the 12th RCMI International Symposium on Health Disparities, Nashville, TN, 2010
[78] C. Hanson, S. J. Goodwin, J. Swant, T. Patel, A. Kenworthy, and H. Khoshbouei
"The dynamic interaction between α-synuclein and dopamine transporter" Presented at the 40th Annual Meeting for the Society for Neuroscience, San Diego, CA, 2010
[79] S. J. Goodwin, C. Hanson, T. Patel, J. Swant, and H. Khoshbouei
"Dopamine Transporter recruits α-synuclein to the plasma membrane"
Presented at the 40th Annual Meeting for the Society for Neuroscience, San Diego, CA, 2010
[80] A. Fennell, J. Gamble-George, J. Swant, M. Ferguson, S. J. Goodwin, T. Patel, T. A. Ansah, and H. Khoshbouei
"The pattern of methamphetamine exposure determines its mnemonic consequences"
[81] S. Nowicki and B. Nowicki
"Downregulation of TLR4 Receptor-New Immunosuppresive Transcriptional Target for Glucocorticoid"
Presented at the 3rd Latin American Congress on Autoimmunity, Buenos Aires, 2010
[82] J. Gamble-George, A. Fennell, J. Swant, and S. J. Goodwin
"Discontinuous and Continuous Methamphetamine Exposures Have Distinct Molecular Targets"
Presented at the 2010 Annual Biomedical Research Conference for Minority Students (ABRCMS), Tampa, FL, 2010
[83] L. Dent, D. Marshall, R. Hulette, and S. Pratap
"Next-gen sequencing of multi-drug resistant Acinetobacter baumannii to determine antibiotic resistance genotypes"
Presented as a Conference Paper in BMC Bioinformatics, 2010, vol. 11 Suppl 16, p. 16
[84] D. J. Alcendor, H. E. Vigil, and W. Q. Zhu
"Pericytes and HIV Neuropathology"
Presented at the 8th Annual Research Symposium in Obstetrics and Gynecology, 2010
[85] D. J. Alcendor, C. N. Marrs, A. R. Chaudhry, S. D. Sweet, and W. Zhu
"Racial Disparities in Bacterial Vaginosis and its Influence on HIV-1 Acquisition" Presented at the 8th Annual Research Symposium in Obstetrics and Gynecology, Meharry Medical College, Nashville, TN, 2010
[86] C. Hanson, S. J. Goodwin, A. Kenworthy, and H. Khoshbouei
"Alpha-synuclein transiently interacts with the dopamine transporter"
Presented at the 39th Annual Meeting of the Society for Neuroscience, Chicago, IL, 2009
[87] S. J. Goodwin, T. Patel, A. Kenworthy, and H. Khoshbouei
[88] S. Chirwa, S. J. Goodwin, J. Swant, and H. Khoshbouei
"A-synuclein interactation with the dopamine transporter stimulates a transporter mediated Cl- current"
Presented at the HIV Prevention Conference, Atlanta, GA, 2009
[90] D. J. Alcendor, C. N. Marrs, S. D. Sweet, and W. Q. Zhu
"Racial Disparities in Bacterial Vaginosis and its Influence on HIV-1 Acquisition" Presented at the HIV Prevention Conference,Atlanta, GA, 2009
1. An effective molecular vaccine for Chagas heart disease was generated by a collaborative effort between MeTRC investigators at Meharry Medical College and the University of Alabama at Birmingham.
This molecular vaccine was discovered via a collaborative effort involving: Dr. Pius Nde (a previously funded METRC Pilot Project PI) who utilized the MeTRC/RCMI Morphology Core (directed by Dr. Shawn Goodwin), in collaboration with the MeTRC Bioinformatics Core (directed by Dr. Sidd Pratap), as well as the laboratory of Dr. Fernando Villalta, (Co-Director of METRC Pilot Projects), and Dr. Quiana Mathews from the University of Alabama at Birmingham (UAB). In addition, postdoctoral scientists at both Meharry and UAB participated. This discovery resulted in the following publication which actually made the cover page of the issue:
Farrow AL, Rachakonda G, Gu L, Krendelchtchikova V, Nde PN, Pratap S, Lima MF, Villalta F*, Matthews QL. 2014. Immunization with hexon modified adenoviral vectors integrated with gp83 epitope provides protection against Trypanosoma cruzi infection. PLoS. Negl. Trop.Dis. 8:e3089. PMC4140675. *Corresponding Author
https://www.plosntds.org/article/browse/issue/info%3Adoi%2F10.1371%2Fissue.pntd.v08.i08
Furthermore, this discovery generated a picture that was selected as the "Biomedical Picture of the Day" by the Medical Research Council Clinical Sciences Centre, UK. It was photographed in the MeTRC/RCMI Morphology Core. See the following link:
https://bpod.mrc.ac.uk/archive/2014/10/13
Chagasdisease, caused by Trypanosoma cruzi and transmitted by blood-sucking triatomine insects affects 8 million people in Latin America causing significant morbidity and mortality. Chagas disease, which was once thought to be confined to endemic regions of Latin America, has now gone global due to human migration, becoming a new worldwide challenge with no vaccines nor effective drug available. Currently, 2-7 million Hispanics with Chagas disease live in North America, posing significant health disparity. Insect vectors have been reported in 43 US states and the disease is now endemic to Central and South Texas and exists there as a zoonosis. As a zoonosis, Chagas disease has proven to be a serious threat to military working dogs, decreasing military operational effectiveness in San Antonio, TX. We used a novel strategy using adenovirus vectors delivering a T. cruzi neutralizing epitope expressed on the invasive forms of the parasite that is highly conserved among strains of T. cruzi to immunized animal modes of Chagas disease with success. The results from this study indicate that the vaccine induced significant protection and elicited neutralizing antibodies that blocked the infection. We conclude that the neutralizing T. cruzi epitope is an essential epitope in the development of an effective molecular vaccine for Chagas disease.
Based on the collaborative studies between both institutions, an NIAID RO1 grant entitled "Novel Adenovirus-Based Chagas Vaccines" was submitted to NIH with two PIs, one from Meharry and the other from the UAB.
2. Oral Presentation from a MeTRC investigator at two important Scientific Meetings
a) Dr. Alcendor was recently invited as a distinguished speaker and panelist to the 7th Annual Ocular Disease and Drug Discovery Conference in San Diego on March 19-20, 2015 in San Diego, CA. This conference is known to showcase novel targets and innovative technologies impacting ocular disease. He will present his latest research published in the Journal of Neuroinflammation on "Retinal Pericytes" that was original funded as a Meharry MeTRC pilot grant.
b) In addition, Dr. Alcendor's research findings were selected for an oral presentation at the distinguished Gordon Conference (Barriers of the CNS) held in New London, New Haven on June 15-20, 2014. His presentation was entitled "Retinal pericytes of the inner blood retinal barrier and cytomegalovirus infectivity: Implications for both CMV induced retinopathy and congenital ocular disease. Dr. Alcendor was also awarded with a Travel Award to give an oral presentation at the meeting. This presentation is a collaborative effort between Meharry and Vanderbilt scientists.
3. Members of the Center for AIDS Health Disparities Research, who were supported by MeTRC Research Pilot Projects, have made significant advancements with regard to the understanding of the pathogenesis of HIV/AIDS infections.
The scientists listed below have elucidated the roles of critical HIV-1 and host molecules that participate in the process of HIV infection, the mechanisms involved in the pathogen/host interface, and the molecular basis of pathology of drug abuse in HIV infection. These studies are significant because they have identified new targets for intervention. These significant developments will facilitate new treatments for HIV/AIDS patients. Moreover, it will help with the management of HIV/AIDS in drug-abusing patients. Below, we briefly indicate their key discoveries and the publications associated with their studies.
3.1 Dr. CV Dash. Dr. Dash has significantly advanced the understanding of how cocaine and methamphetamine act in HIV infection. These studies are significant because they have implications in HIV-1 pathogenesis in drug-abusing patients. Additionally, these studies are advancing the understanding of the pathology caused by HIV- positive patients abusing drugs. The goal is to develop better strategies to manage HIV infection in drug-abusing patients. Dr. Dash's laboratory has discovered that cocaine regulates HIV-integration in primary CD4+ T cells, induces CD4+ T cell apoptosis, and enhances HIV replication in CD4+ T cells by down regulating MiR-125b. These important discoveries resulted in the following 4 recent publications:
a) Cocaine modulates HIV-1 integration in primary CD4+ T cells: implications in HIV-1 pathogenesis in drug-abusing patients. Addai AB, Pandhare J, Paromov V, Mantri CK, Pratap S, Dash C. J Leukoc Biol. 2015 Feb 17. pii: jlb.4A0714-356R. [Epub ahead of print] PMID: 25691383 (PMCID in process)
b) Cocaine enhances HIV-1-induced CD4(+) T-cell apoptosis: implications in disease progression in cocaine-abusing HIV-1 patients. Pandhare J, Addai AB, Mantri CK, Hager C, Smith RM, Barnett L, Villalta F, Kalams SA, Dash C. Am J Pathol. 2014 Apr;184(4):927-36. Epub 2014 Jan 31.PMID: 24486327; PMCID: PMC3970001
c) Methamphetamine inhibits HIV-1 replication in CD4+ T cells by modulating anti-HIV-1 miRNA expression. Mantri CK, Mantri JV, Pandhare J, Dash C. Am J Pathol. 2014 Jan;184(1):92-100. PMID: 24434277; PMCID: PMC3873480
d) Cocaine enhances HIV-1 replication in CD4+ T cells by down-regulating MiR-125b. Mantri CK, Pandhare Dash J, Mantri JV, Dash C. PLoS One. 2012;7(12):e51387. PMID: 23251514; PMCID: PMC3520918
3.2 Dr. Bindong Liu. Dr. Liu's laboratory has discovered two novel approaches which are important to inhibiting HIV replication. His group has discovered that a molecule from an oral bacteria Streptococcus cristatus, which is part of the normal oral flora, induces APOBEC3 expression to actually inhibit HIV-1 replication. This discovery is significant because the new bacterial molecule will be used as a new treatment for HIV infection. In his second important discovery, he found that an E2 protein of the GB virus Type C inhibits HIV-1 assembly through interference with HIV-1 gag plasma membrane. This discovery is significant because it has the potential to be used as a new treatment for HIV infection. In addition, he has discovered that the passage of HIV through vaginal epithelia cells is dependent on trafficking to the endocytic-recycling pathway. This study is significant because it documents that manipulating the endocytic recycling pathway is important to prevent vaginal HIV infection. These important discoveries resulted in the following 3 recent publications:
a) Heat-stable molecule derived from Streptococcus cristatus induces APOBEC3 expression and inhibits HIV-1 replication. Wang Z, Luo Y, Shao Q, Kinlock BL, Wang C, Hildreth JE, Xie H, Liu B. PLoS One. 2014 Aug 28;9(8):e106078. PMID: 25165817; PMCID: PMC4148350.
b) Transcytosis of HIV-1 through vaginal epithelial cells is dependent on trafficking to the endocytic recycling pathway. Kinlock BL, Wang Y, Turner TM, Wang C, Liu B. PLoS One. 2014 May 15;9(5):e96760. PMID: 24830293; PMCID: PMC4022679.
c) GB virus type C E2 protein inhibits human immunodeficiency virus type 1 assembly through interference with HIV-1 gag plasma membrane targeting. Timmons CL, Shao Q, Wang C, Liu L, Liu H, Dong X, Liu B. J Infect Dis. 2013 Apr;207(7):1171-80. PMID: 23303812; PMCID: PMC3583272.
3.3 Dr. Waldemar Popik. Dr. Popik's laboratory has discovery that the innate immune factor apolipoprotein L1 inhibits HIV-1 replication by multiple mechanisms. His group found that the APOL1 protein targeted HIV-1 Gag for degradation by the endolysosomal pathway. They found that APOL1 stimulated both endocytosis and lysosomal biogenesis by promoting nuclear localization of transcription factor EB (TFEB) and expression of TFEB target genes. Moreover, they demonstrated that APOL1 depletes the cellular viral accessory protein Vif, which counteracts the host restriction factor APOBEC3G, via a pathway involving degradation of Vif in lysosomes and by secretion of Vif in microvesicles. As a result of Vif depletion by APOL1, APOBEC3G was not degraded and reduced infectivity of progeny virions. In support of this model, Dr. Popik's group also showed that endogenous expression of APOL1 in differentiated U937 monocytic cells stimulated with IFN-γ resulted in a reduced production of virus particles. This finding supports the hypothesis that induction of APOL1 contributes to HIV-1 suppression in differentiated monocytes. This study is significant because deciphering the precise mechanism of APOL1-mediated HIV-1 restriction may facilitate the design of unique therapeutics to target HIV-1 replication. This crucial discovery resulted in the following recent publication:
a) The innate immune factor apolipoprotein L1 restricts HIV-1 infection. Taylor HE, Khatua AK, Popik W. J Virol. 2014 Jan;88(1):592-603. PMID: 24173214; PMCID: PMC3911732.
3.4 Dr. Xinhong Dong. Dr. Dong's lab has elucidated the mechanism of HIV-1 particle release. His research findings demonstrated that the intact and stable AP-3 complex, a heterotetramer that is involved in signal-mediated protein sorting to endosomal-lysosomal organelles, is required for HIV-1 assembly and release, and the involvement of the AP-3 complex in late stages of the HIV-1 replication cycle is independent of clathrin-mediated endocytosis. This study is significant because untangling the detailed mechanism of HIV-1 particle assembly may facilitate the design of novel therapeutics to block HIV-1 infection.
Dr. Dong's important discovery resulted in the following recent publication:
a) Defective HIV-1 particle assembly in AP-3-deficient cells derived from patients with Hermansky-Pudlak syndrome type 2. Liu L, Sutton J, Woodruff E, Villalta F, Spearman P, Dong X. J Virol. 2012 Oct;86(20):11242-53. PMID: 22875976; PMCID: PMC3457180.
This publication was spotlighted by the Editors of the Journal of Virology in the Journal Issue.
3.5 Dr. Donald Alcendor. Dr. Alcendor studies the mechanisms of pathogenesis of the Human cytomegalovirus (HCMV), which is the leading infectious cause of vision loss among congenitally infected children. Retinal pericytes play an essential role in maintaining the retinal vascular and endothelial cell proliferation. However, the role of retinal pericytes in ocular HCMV pathogenesis is still unknown. Dr. Alcendor's findings indicate that in retinal pericytes, HCMV induces proinflammatory and angiogenic cytokines. In the Tricell culture model of the inner blood-retinal barrier (IBRB) (retinal endothelial, pericytes, Müller cells), pericytes likely serve as an amplification reservoir, which contributes, to retinal inflammation and angiogenesis. These studies are significant because they point out that it is necessary to develop IBRB model systems to better understand the mechanisms involved in progressive retinopathies and to provide more efficient methods for a timely evaluation of systemic therapies that must circumvent the IBRB.
Dr. Alcendor, in collaboration with scientists at Vanderbilt University, has developed for the first timea "neurovascular unit on a chip" with implications for translational applications including HIV-I infection. This novel technological platform, which combines innovative microfluidics, cell culture, analytical instruments, bioinformatics, control theory, neuroscience, and drug discovery, will replicate chemical communication, molecular trafficking, and inflammation in the brain. The platform will enable targeted and clinically relevant nutritional and pharmacologic interventions for or prevention of such chronic diseases as obesity and acute injury such as stroke, and will uncover potential adverse effects of drugs. If successful, this project will produce clinically useful technologies and reveal new insights into how the brain receives, modifies, and is affected by drugs, other neurotropic agents, and diseases. These novel studies resulted in the following two recent publications:
a) Retinal pericytes and cytomegalovirus infectivity: implications for HCMV-induced retinopathy and congenital ocular disease. Wilkerson I, Laban J, Mitchell JM, Sheibani N, Alcendor DJ. J Neuroinflammation. 2015 Jan 9;12(1):2. PMID: 25573478; PMCID: PMC4314746.
b) Neurovascular unit on a chip: implications for translational applications. Alcendor DJ, Block FE 3rd, Cliffel DE, Daniels JS, Ellacott KL, Goodwin CR, Hofmeister LH, Li D, Markov DA, May JC, McCawley LJ, McLaughlin B, McLean JA, Niswender KD, Pensabene V, Seale KT, Sherrod SD, Sung HJ, Tabb DL, Webb DJ, Wikswo JP. Stem Cell Res Ther. 2013;4 Suppl 1:S18. PMID: 24564885; PMCID: PMC4029462.
4) Several faculty members in the Center for AIDS Health Disparities Research at Meharry, (that were previously funded through MeTRC Pilot Project funding), have effectively collaborated with scientists at Vanderbilt and the TN Department of Health in writing and submitting a successful Tennessee Center for AIDS Research (TN-CFAR) grant-1P30AI110527-01A1, which has received a fundable impact score of 12.
The TN-CFAR involves Vanderbilt University, Meharry Medical College and the TN Health Department, with separate budget components for each institution. Meharry scientists will participate by leading and co-leading components of the TN-CFAR. Meharry's participation will facilitate the expansion of various types of HIV research at Meharry and will enhance the HIV biological and clinical research enterprise.
5) School of Graduate Studies and Research Students Are Top Winners at Health Disparities Conference
Two graduate students won the first and second place awards at the recent ISMHHD NIH Conference 2014 in Bethesda, MD.
Both students are mentored by MeTRC investigator, Dr. CV. Dash.
Amma Addai (top photo) and LaKeisha Summers (bottom photo) were winners of first and second place, respectively, in the Graduate Student Category at the Minority Health and Health Disparities Grantees' Conference held in National Harbor, Maryland in December, 2014.
Addai's presentation was titled "Cocaine enhances HIV-1 integration in CD4+ T cells" and Summers' presented a poster called "Role of Prolidase in Neuronal Dysfunction of Cocaine Abuse."
The 2014 Student Poster Competition is a program designed and developed to foster and support the innovation, ingenuity and intellectual integrity of future scientists dedicated to the improvement of minority health and the elimination of health disparities from a global perspective. Furthermore, the competition supports the future of education and the evolution of science and excellence in developing students to lead the charge of discovery and leadership.
6) MeTRC Pilot Project investigators have played important roles in the scientific peer review community serving as Editors, Editors in Chief, Academic Editors, and members of Editorial Boards for Scientific Journals.
Dr. Bindong Liu, Editor-In-Chief, Journal of Antivirals and Antiretroviral
Dr. CV. Dash, Academic Editor, PLOS ONE
Dr. Xinhong Dong, Editor, AIDS and RecentAdvancements & Editorial Board member, The Journal ofHIV/AIDS Research and Therapy, the Journal JSM Microbiology, the Journal of AIDS & Its Research and Austin Journal of Clinical Immunology
Dr. Donald Alcendor, Editorial Board member, Journal of Bioengineering and Biomedical Science, The Journal HIV/AIDS Research and Therapy, The Journal of Immunology and ClinicalResearch, Austin Journal of HIV/AIDS Research, Journal of Clinical Oncology & Research, Journal of CancerPrevention & Current Research, andAnnals of Clinical and Medical Microbiology
Dr. Bindong Liu, Editorial Board member, The Journal of AIDS and Clinical Research
Dr. Waldemar Popik, Editorial Board member,Frontiers of Virology
Dr. Stella Nowicki, Editorial Board member The World Journal of Clinical Infectious Diseases, Advances in Medicine (OB/GYN subject area) and The Journal of Immunology and Clinical Research
Dr. Xua Xi, Editorial Board member, Frontiers in Cellular and Infection Microbiology
7) The Collaborations & Partnerships Key Activity has been active in creating an environment that has enhanced research activities through the collaborative efforts of internal and external investigators resulting in scholarly publications and partnerships. Examples are listed in items 1,2,3 and 4 of these MeTRC scientific highlights.
Principle Investigator and Executive Director
Samuel E. Adunyah, Ph.D.
Chair and Professor
Biochemistry and Cancer Biology
School: Medicine
Email: sadunyah@mmc.edu
View Publications
Pilot Project Leader
Fernando Villalta, Ph.D.
Email: fvillalta@mmc.edu
Senior Program Administrators
Senior Administrative Assistant, Professional Development
ksmith@mmc.edu
Denise Holland, M.A.
Program Coordinator, Pilot Projects
lclarke@mmc.edu
Ketia Barnes
kbarnes@mmc.edu
Siddharth Pratap M.S., Ph.D.
School of Graduate Studies and Research;
spratap@mmc.edu
Consuelo Wilkins, M.D., M.Sci.
Executive Director,
Meharry-Vanderbilt Alliance;
Collaborations and Partnerships Co-Leader
consuelo.h.wilkins@meharry-vanderbilt.org
Community Based Research Leader
Evaluation Milestones
John Murray, M.D., Ph.D.
Professor, Internal Medicine;
Clinical and Translational Research Center
jmurray@mmc.edu
Konya Williams
Clinical Research Coordinator III,
kwilliams2@mmc.edu
Christine Minja-Trupin, M.P.H, Ph.D.
Graduate Studies and Research;
Director, Evaluation Milestones
Research Design, Biostatistics, and Clinical Research Ethics (DBRE)
J. Shawn Goodwin, Ph.D.
Associate Professor,
Biochemistry and Cancer Biology;
Technologies and Services
Core Laboratories Co- Leader
jgoodwin@mmc.edu
Stephania Miller-Hughes, Ph.D.
Associate Professor, Surgery;
Research Design, Biostatistics,
Clinical Research Ethics
smiller@mmc.edu

redpajama_set_name: RedPajamaCommonCrawl


Most vacationers complain that their trip seemed too short — that "I was just starting to slow down." Days passing too quickly definitely was not my experience when my wife Daya and I spent eight days at Turtle Island in Fiji this October. Time disappeared. The holiday felt endless, as if more experiences always awaited.
I fell into the rhythm of nature and the Fijians. Since I was on an island, the passage of high and low tides became important — their times even appeared daily on the Bula Board. The shifting water levels changed the view from my beach hammock. I developed a relationship with the two birds that visited during low tide to feed on the small crabs — so much so that I became concerned if they were not there!
Paradise may lie far, but it's comparatively easy to reach. A 10-hour overnight Air Pacific flight (see Travel Tips sidebar) from Los Angeles to Nadi, Fiji, arrived in the early morning. After the decent night's sleep on-board I enjoyed the exhilaration of my first seaplane ride. One half-hour of flying at 1,000 feet over the changing shades of blue water to the Yasawa Island group culminated in an ever-so-gentle landing in the lagoon fronting Turtle Island. Speaking of lagoons: Turtle Island served as location for the 1979 film The Blue Lagoon starring Brooke Shields, imprinting it as the quintessential tropical island.
An integral escape for the rich and famous, Turtle Island has hosted the likes of Britney Spears, Charlize Theron, Ringo Starr, Rupert Murdock and football hero Kurt Warner, to name just a few luminaries. But all glittery chitchat ends there. At Turtle Island everyone was treated with equal respect and fabulous service. In shorts and T-shirts we were all on an equal footing. No flashy jewelry or expensive cruise attire. What we all shared: wide smiles and an appreciation of where we were.
With a maximum capacity of 28 guests housed in 14 "bures" (pronounced boo-rays; bures are small cottages) on the expansive beach, a staff of 90 kept the place running. Half of the guests were on their honeymoon and the remainder of the visitors were celebrating some special event or just needing to get away. Over 50 percent of the guests at Turtle Island are returnees.
Once on Turtle Island, you join a Fijian community. The staff live on the island and visit their own off-island families during frequent breaks. Guest constantly interact with the staff, exchanging shouts of "Bula!" (hello). Each evening a different division of the staff (kitchen workers, maintenance crew, etc.) sponsors the kava ceremony. Guests and staff participate in this ritual drinking of a brew made from the yangona root. Drinking this mildly intoxicating beverage forms part of the social life of Fijians and other South Pacific cultures — a time for singing songs and reviewing the day's activities.
Now about the luxury. Our bure was more of a small house than a bungalow. The resort manager, Felipe, brought us to our accommodations that first morning of our arrival, and excitedly showed us the beautiful writing desk, four-poster bed and cabinetry all made from exquisite local hardwoods. Many afternoons, I lay in bed and marveled at the intricate inner-roof design of pillars and woven palm set off with cowry shells. We even had a hot tub with wraparound windows overlooking tropical foliage.
When we arranged our trip we were given a "customer service agent for life." In advance of our arrival we received the list of wines Turtle offered; when we arrived, our favo-rite champagne was already on ice and our choices of wines stocked in the cabinet. Since we had been told of the Bose stereo system, we brought along some of our favorite CDs to set the stage.
Within moments of arriving on the island we met Tommy, our "Bure Mama" (actually Bure Papa since he was a guy). It is difficult to describe the role of the Bure Mama. Although the practice might be unique to Turtle Island resort, it actually is an extension of Fijian hospitality.
Tommy was there to take care of our individual needs. Fifteen minutes before breakfast, he took our orders so that our meal and espresso coffee awaited us when we arrived at the table on the beach. He provided the endless profusion of hibiscus flowers that appeared everywhere: in the foot-bath in front of our bure; on the bed in the afternoon; on our vanities in the dressing area; woven through the indoor tropical plants. When I returned from a scuba dive, Tommy had a fresh fruit drink waiting.
Romantic interludes and privacy are keys to the days at Turtle Island. Every other day we could spend the afternoon (or morning) at any of the seven isolated beaches that inlay the island. At the designated hour, a boat or electric cart took us to the strand of our choice where we would have the white sands and palm trees all to ourselves for as many hours as we desired. Selected beforehand, our picnic meal accompanied us to the site. How often do we get a chance to have a beach all to ourselves!
We had walkie-talkies with us in case we needed additional items or wanted to extend or shorten our time at the beach. Each day the most difficult choice became returning to a beach we loved or venturing to a new one.
Although we enjoyed dining with all of the guests at the main dining table magnificently set on the beach, a few nights we chose to eat alone. We had the unique experience of dining on one of the floating platforms in the middle of the lagoon. A canopy of stars and the rising moon enhanced the romantic setting. Our platform was lit with kerosene lamps, and our food arrived by boat.
As our eyes became accustomed to the dark, we extinguished the lanterns and ate by moonlight. After an hour the boat returned and brought us back to the mainland for dessert with the rest of the guests. On another occasion we dined by ourselves at the end of the dock with the entire path lit with small lamps. This time we were treated to the flapping sounds of small fish attracted by the light of the lanterns.
Romance was balanced with activities. Each morning I was picked up at 10 a.m. sharp to go scuba diving, while my wife caught up on some "hammock-reading." The sleep-in hour of 10 a.m. for diving (morning dives generally start way earlier) came about because the resort runs on "Turtle Time": one hour later than of the rest of Fiji. The time-switch started during the filming of The Blue Lagoon to allow more daylight hours for shooting, and it stuck. The diving at sites such as Neptune's Thumb, Bonzai and The Zoo abounded with tropical fish and the soft corals for which Fiji is famous.
Although I like to view fish from under water, several guests went out each day to experience the thrill of deep sea fishing, also included in a stay at Turtle. They returned from their trips with tuna and mackerel, which the island chefs turned into delicacies such as sashimi at the evening meal.
Back on the island itself we had the opportunity to bike along miles of dirt roads that crisscross the palms and hibiscus flowers. Early morning was my favorite time: the birds were declaring the day and the air was still cool. Another early morning offering was the sunrise horseback ride. Although we didn't go ourselves, several couples said that it fulfilled some of their own fantasies.
On the last afternoon on the Island, as we walked along the dock to our waiting seaplane, Tommy, our "Bure Papa," placed a garland of flowers around our necks. After some hugs and farewells we boarded the plane with the scent of the flowers and the sea breezes filling the plane.
After takeoff, the pilot asked for our garlands, which he then threw out the opened windows (flying at 1,000 feet makes an open window a fun experience). The custom of throwing the garlands and having the tides bring them back to Turtle Island insures that we too will return to this timeless paradise soon.
FOR MORE INFORMATION on Turtle Island or to make reservations call . View their website at www.turtlefiji.com. E-mail: usa@turtlefiji.com.
• Getting There: Air Pacific offers 747 direct service to Fiji from Los Angeles three times a week, plus flights three times a week from Vancouver through Honolulu: Tel. ; Website:www.airpacific.com.
• Children in Paradise: Twice a year — from the second week in December to the second week in January, and for three weeks from late June until mid-July — Turtle Island runs a special program for children accompanying their parents. Called Na Vonu Club, the program matches each child with kids of their own age, as well as their own Bula Playmate or childcare provider. Children dine with other campers except for a few evenings when they eat with their parents. Daily activities range from fishing and horseback riding to snorkeling and water polo.
• Getting Married: Weddings are a natural at Turtle Island. Couples can choose either an intimate private wedding on a secluded beach, or the full Fijian event with flower-studded wedding barge (see photo), choir and all island guests in attendance.
• "Client Manager for Life": When someone makes a reservation at Turtle Island, the guest is assigned a personal customer-service representative who e-mails photos to a list of selected relatives and friends. This client manager made sure that a favorite champagne awaited visitors on arrival, and that their choices of red and white wines were stocked in their bures.
• The Ultimate Massage: Upon arrival guests are offered a free one-half hour Lomi massage in the privacy of their bure. Guests can also make appointments for a two masseuse, four-hand version. Not to be missed!


text:
...like dreams, statistics are a form of wish fulfillment by Benjamin Broening
De Cinque, P., 3 Feb 2017
Research output: Non-traditional research output › Performance
« Art » de Yasmina Reza ou 'l'immense vulnérabilité' du masculin
Jaccomard, H., 14 Mar 2018, In : European Drama and Performance Studies. 1, 10, p. 247-263
(2491) proposal to conserve the name Rhizophagus with a conserved type (Fungi: Glomeromycota: Glomeraceae)
Walker, C., Trappe, J. M., Schüßler, A., Hawksworth, D. L., Cazares, E., Elliott, T. F. & Redecker, D., 1 Feb 2017, In : Taxon. 66, 1, p. 199-200 2 p.
(Almost) Dark Galaxies in the ALFALFA Survey: Isolated HI-bearing Ultra-diffuse Galaxies
Leisman, L., Haynes, M. P., Janowiecki, S., Hallenbeck, G., Jozsa, G., Giovanelli, R., Adams, E. A. K., Neira, D. B., Cannon, J. M., Janesh, W. F., Rhode, K. L. & Salzer, J. J., 20 Jun 2017, In : The Astrophysical Journal. 842, 2, 17 p., 133.
(Methylthio)phenol semiochemicals are exploited by deceptive orchids as sexual attractants for Campylothynnus thynnine wasps
Bohman, B., Phillips, R. D., Flematti, G. R. & Peakall, R., Apr 2018, In : Fitoterapia. 126, p. 78-82 5 p.
(Non)local and (non)linear free boundary problems
Dipierro, S. & Valdinoci, E., 2018, In : DISCRETE & CONTINUOUS DYNAMICAL SYSTEMS. SERIES A. 11, 3, p. 465-476 12 p.
Free Boundary Problem
(Planar-Chiral) Ferrocenylmethanols: From Anionic Homo Phospho-Fries Rearrangements to -Ferrocenyl Carbenium Ions
Korb, M., Mahrholdt, J. & Lang, H., 15 Sep 2017, In : European Journal of Inorganic Chemistry. 34, p. 4028-4048 21 p.
[Book review] Death of the public university? Uncertain futures for higher education in the knowledge economy, edited by Susan Wright and Cris Shore
McKenzie, L. E., 2018, In : Anthropological Forum: a journal of social anthropology and comparative sociology. 28, 3, p. 310-312 3 p.
[Book review] Marriage rites and rights, edited by Joanna Miles, Perveez Mody, and Rebecca Probert
McKenzie, L. E., 1 May 2018, In : Journal of the Royal Anthropological Institute. 24, 2, p. 407-409 3 p.
[Book review] The meaning of money in China and the United States: The 1986 Lewis Henry Morgan lectures, by Emily Martin
McKenzie, L. E., 3 Jul 2017, In : Anthropological Forum: a journal of social anthropology and comparative sociology. 27, 3, p. 295 297 p., 10.1080/00664677.2017.1347248.
[FIHSIHKAHLVRRCHUWAHL<>]: Prototyping Architectural User-Interfaces in Urban Public Space.
Cameron, R. & Smolik, A., 13 Jun 2018, In : International Journal of Arts and Technology. 10, 4, p. 301-317 17 p.
[FIHSIHKAHLVRRCHUWAHL<>] Conceptual Film
Cameron, R. & Smolik, A., Nov 2017
Research output: Non-traditional research output › Recorded/rendered creative work
Acoustic waves
Interfaces (computer)
[Review of] Barbara Levick, Vespasian. Second Edition. Roman Imperial Biographies. London; New York: Routledge, 2017. Pp. xxvim 345. ISBN 9780415708890. $140.00/£90.00.
Mallan, C., Feb 2017, In : Bryn Mawr Classical Review . 2017.02.53
[Review of] C. HIGBIE, COLLECTORS, SCHOLARS, AND FORGERS IN THE ANCIENT WORLD: OBJECT LESSONS. Oxford: Oxford University Press, 2017. Pp. xv + 276, illus. ISBN 9780198759300. £65.00.
Mallan, C. T., 2018, In : Journal of Roman Studies.
[Review of] Caitlin C. Gillespie, <i>Boudica: Warrior Woman of Roman Britain</i>. New York: Oxford University Press, 2018. Pp. 193 + xv. ISBN 9780190609078. $74.00.
Mallan, C. T., Aug 2018, In : Bryn Mawr Classical Review .
[Review of] M. Toher, Nicolaus of Damascus. The Life of Augustus and the Autobiography. Edited with Introduction, Translations, and Historical Commentary. Cambridge: Cambridge University Press, 2017. pp. xii + 488. £99.99. ISBN: 9781107075610.
Mallan, C. T., 2017, In : STRATA: Bulletin of the Anglo-Israel Archaeological Society. 35, p. 188-190
[Review of] Ronald Syme, Approaching the Roman Revolution: Papers on Roman Republican History. (edited by Federico Santangelo). Oxford; New York: Oxford University Press, 2016. Pp. xv, 428. ISBN 9780198767060. $140.00.
Mallan, C., 2017, In : Bryn Mawr Classical Review .
#familygoals: Family Influencers, Calibrated Amateurism, and Justifying Young Digital Labor
Abidin, C., 2017, In : Social Media + Society. 3, 2, p. 1-15
0402 Does lung cancer incidence and mortality differ with the type of asbestos fibre? : evidence from Western Australia
Sodhi-Berry, N., De Klerk, N., Franklin, P., Brims, F., Peters, S., Olsen, N. & Musk, A., 2017, In : Occupational and Environmental Medicine. 74, S1, p. A126
Research output: Contribution to journal › Abstract/Meeting Abstract
1.142 mu m GaAsBi/GaAs Quantum Well Lasers Grown by Molecular Beam Epitaxy
Wu, X., Pan, W., Zhang, Z., Li, Y., Cao, C., Liu, J., Zhang, L., Song, Y., Ou, H. & Wang, S., Jun 2017, In : ACS Photonics. 4, 6, p. 1322-1326 5 p.
1.39 Ga mafic dyke swarm in southwestern Yilgarn Craton marks Nuna to Rodinia transition in the West Australian Craton
Stark, J. C., Wang, X. C., Li, Z. X., Denyszyn, S. W., Rasmussen, B. & Zi, J. W., 1 Oct 2018, In : Precambrian Research. 316, p. 291-304 14 p.
dike swarm
1.6 Ga crustal thickening along the final Nuna suture
Pourteau, A., Smit, M. A., Li, Z-X., Collins, W. J., Nordsvan, A. R., Volante, S. & Li, J., Nov 2018, In : Geology. 46, 11, p. 959-962 4 p.
119 loci influencing intraocular pressure provide new insight into primary open angle glaucoma susceptibility and age of onset.
Craig, J. E., Hewitt, A. W., Mackey, D., Graham, S. L., Healey, P. R., White, A. J. R., Landers, J., Casson, R., Souzeau, E., Burdon, K. P., Gharahkhani, P. & MacGregor, S., Jul 2018, In : Investigative ophthalmology & visual science. 59, 9, 3 p., 1177.
11 years' follow-up of trastuzumab after adjuvant chemotherapy in HER2-positive early breast cancer: final analysis of the HERceptin Adjuvant (HERA) trial
Cameron, D., Piccart-Gebhart, M. J., Gelber, R. D., Procter, M., Goldhirsch, A., de Azambuja, E., Castro, G., Untch, M., Smith, I., Gianni, L., Baselga, J., Al-Sakaff, N., Lauer, S., McFadden, E., Leyland-Jones, B., Bell, R., Dowsett, M. & Jackisch, C., 25 Mar 2017, In : The Lancet. 389, 10075, p. 1195-1205 11 p.
Trastuzumab
Adjuvant Chemotherapy
Disease-Free Survival
13th International conference on steel, space and composite structures: volume of abstracts
Aslani, F. (ed.), Ma, G. (ed.) & Uy, B. (ed.), 2018.
18F PET with florbetaben for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Martínez, G., Vernooij, R. W., Fuentes Padilla, P., Zamora, J., Flicker, L. & Bonfill Cosp, X., 22 Nov 2017, In : Cochrane Database of Systematic Reviews. 11, CD012883.
4-(N-methylamino)-4'-(2-(2-(2-fluoroethoxy)ethoxy)ethoxy)stilbene
Early Diagnosis
18F PET with florbetapir for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Martínez, G., Vernooij, R. W. M., Fuentes Padilla, P., Zamora, J., Bonfill Cosp, X. & Flicker, L., 22 Nov 2017, In : Cochrane Database of Systematic Reviews. 11, CD012216.
florbetapir
18F PET with flutemetamol for the early diagnosis of Alzheimer's disease dementia and other dementias in people with mild cognitive impairment (MCI)
Martínez, G., Vernooij, R. W. M., Fuentes Padilla, P., Zamora, J., Flicker, L. & Bonfill Cosp, X., 22 Nov 2017, In : Cochrane Database of Systematic Reviews. 11, CD012884.
flutemetamol
18O-labeled phosphate applied to soil appears in the shoots of maize after uptake by roots but not after uptake by an arbuscular mycorrhizal fungus
Qin, Y., Duan, G., Zhao, Z., Tian, H. & Solaiman, Z. M., 27 Jun 2018, In : Mycorrhiza. p. 1-7 7 p.
1 alpha,20S-Dihydroxyvitamin D-3 Interacts with Vitamin D Receptor: Crystal Structure and Route of Chemical Synthesis
Lin, Z., Chen, H., Belorusova, A. Y., Bollinger, J. C., Tang, E. K. Y., Janjetovic, Z., Kim, T-K., Wu, Z., Miller, D. D., Slominski, A. T., Postlethwaite, A. E., Tuckey, R. C., Rochel, N. & Li, W., 31 Aug 2017, In : Scientific Reports. 7, 10 p., 10193.
2,4-D and dicamba resistance mechanisms in wild radish: subtle, complex and population specific?
Goggin, D. E., Kaur, P., Owen, M. J. & Powles, S. B., 24 Sep 2018, In : Annals of Botany. 122, 4, p. 627-640 14 p.
auxins
2.7 Ga plume associated VHMS mineralization in the Eastern Goldfields Superterrane, Yilgarn Craton: Insights from the low temperature and shallow water, Ag-Zn-(Au) Nimbus deposit
Hollis, S. P., Mole, D. R., Gillespie, P., Barnes, S. J., Tessalina, S., Cas, R. A. F., Hildrew, C., Pumphrey, A., Goodz, M. D., Caruso, S., Yeats, C. J., Verbeeten, A., Belford, S. M., Wyche, S. & Martin, L. A. J., 1 Apr 2017, In : Precambrian Research. 291, p. 119-142 24 p.
massive sulfide
2016 Best Paper Award
Gao, N., Yang, J., Zhao, W. & Li, X., 3 Apr 2017, In : Ships and Offshore Structures. 12, 3, p. 303 1 p.
2016 RANZCOG Ian McDonald Memorial Oration: 'The whole nine months lasts a lifetime'
Newnham, J., 2017, In : Australian and New Zealand Journal of Obstetrics and Gynaecology. 57, 2, p. 134-138
2017 WSES guidelines for the management of iatrogenic colonoscopy perforation
de'Angelis, N., DiSaverio, S., Chiara, O., Sartelli, M., Martínez-Pérez, A., Patrizi, F., Weber, D. G., Ansaloni, L., Biffl, W., Ben-Ishay, O., Bala, M., Brunetti, F., Gaiani, F., Abdalla, S., Amiot, A., Bahouth, H., Bianchi, G., Casanova, D., Coccolini, F., Coimbra, R. & 31 others, De'Angelis, G. L., DeSimone, B., Fraga, G. P., Genova, P., Ivatury, R., Kashuk, J. L., Kirkpatrick, A. W., LeBaleur, Y., Machado, F., Machain, G. M., Maier, R. V., Chichom-Mefire, A., Memeo, R., Mesquita, C., SalameaMolina, J. C., Mutignani, M., Manzano-Núñez, R., Ordoñez, C., Peitzman, A. B., Pereira, B. M., Picetti, E., Pisano, M., Puyana, J. C., Rizoli, S., Siddiqui, M., Sobhani, I., ten Broek, R. P., Zorcolo, L., Carra, M. C., Kluger, Y. & Catena, F., 24 Jan 2018, In : World Journal of Emergency Surgery. 13, 5.
Conservative Treatment
2017 WSES guidelines on colon and rectal cancer emergencies: Obstruction and perforation
Pisano, M., Zorcolo, L., Merli, C., Cimbanassi, S., Poiasina, E., Ceresoli, M., Agresta, F., Allievi, N., Bellanova, G., Coccolini, F., Coy, C., Fugazzola, P., Martinez, C. A., Montori, G., Paolillo, C., Penachim, T. J., Pereira, B., Reis, T., Restivo, A., Rezende-Neto, J. & 31 others, Sartelli, M., Valentino, M., Abu-Zidan, F. M., Ashkenazi, I., Bala, M., Chiara, O., de' Angelis, N., Deidda, S., De Simone, B., Di Saverio, S., Finotti, E., Kenji, I., Moore, E., Wexner, S., Biffl, W., Coimbra, R., Guttadauro, A., Leppäniemi, A., Maier, R., Magnone, S., Mefire, A. C., Peitzmann, A., Sakakushev, B., Sugrue, M., Viale, P., Weber, D., Kashuk, J., Fraga, G. P., Kluger, I., Catena, F. & Ansaloni, L., 13 Aug 2018, In : World Journal of Emergency Surgery. 13, 1, 36.
Rectal Neoplasms
Self Expandable Metallic Stents
2018 Editors' commentary
Thompson, A., Antel, J., Carroll, W. M. & Geurts, J. J. G., 1 Oct 2018, In : Multiple Sclerosis Journal. 24, 11, p. 1394-1395 2 p.
21st Biennale of Sydney: Superpositions: Equilibrium and Engagement
Jorgensen, D., 23 Mar 2018, In : Artlink: Australian contemporary art quarterly. p. n/a n/a.
21st-century rise in anthropogenic nitrogen deposition on a remote coral reef
Ren, H., Chen, Y-C., Wang, X. T., Wong, G. T. F., Cohen, A. L., DeCarlo, T. M., Weigand, M. A., Mii, H-S. & Sigman, D. M., 2017, In : Science. 356, 6339, p. 749-752 4 p.
Nitrogen Isotopes
227th ENMC International Workshop: Finalizing a plan to guarantee quality in translational research for neuromuscular diseases Heemskerk, Netherlands, 10-11 February 2017
Willmann, R., Buccella, F., De Luca, A. & Grounds, M. D., Feb 2018, In : Neuromuscular Disorders.
24 Years Later - China Finally Centralizes Its Tax Administration
Li, N. & Krever, R. E., 2018, In : Tax Notes International. 90, 5, p. 539-544 6 p.
sale of good
250 K: A YOUTH ALLERGY AWARENESS PROJECT BY THE NATIONAL ALLERGY STRATEGY
Vale, S., Loh, R., Smith, J., Aiken, J., Salter, S. & Said, M., Sep 2017, In : Internal Medicine Journal (Print). 47, p. 20-20 1 p.
25-Hydroxyvitamin D Concentrations and Clostridium difficile Infection: A Meta-Analysis
Furuya-Kanamori, L., Wangdi, K., Yakob, L., McKenzie, S. J., Doi, S. A. R., Clark, J., Paterson, D. L., Riley, T. V. & Clements, A. C. A., 1 Jul 2017, In : Journal of Parenteral and Enteral Nutrition. 41, 5, p. 890-895 6 p.
Clostridium Infections
28-homobrassinolide regulates antioxidant enzyme activities and gene expression in response to salt- and temperature-induced oxidative stress in Brassica juncea
Kaur, H., Sirhindi, G., Bhardwaj, R., Alyemeni, M. N., Siddique, K. H. M. & Ahmad, P., Dec 2018, In : Scientific Reports. 8, 1, 13 p., 8735.
2D and 3D face recognition using convolutional neural network
Hu, H., Shah, S. A. A., Bennamoun, M. & Molton, M., 19 Dec 2017, TENCON 2017 - 2017 IEEE Region 10 Conference. USA: IEEE, Institute of Electrical and Electronics Engineers, Vol. 2017-December. p. 133-138 6 p.
2D Bayesian automated tilted-ring fitting of disc galaxies in large HI galaxy surveys: 2DBAT
Oh, S. H., Staveley-Smith, L., Spekkens, K., Kamphuis, P. & Koribalski, B. S., 1 Jan 2018, In : Monthly Notices of the Royal Astronomical Society. 473, 3, p. 3256-3298 43 p.
disk galaxies
Markov chain
2D versus 3D MFI zeolite: The effect of Si/Al ratio on the accessibility of acid sites and catalytic performance
Wei, R., Yang, H., Scott, J. A., Aguey-Zinsou, K. F. & Zhang, D., 1 Jun 2018, In : Materials Today Chemistry. 8, p. 1-12 12 p.
Lewis Acids
Catalyst activity
2MTF-VI. Measuring the velocity power spectrum
Howlett, C., Staveley-Smith, L., Elahi, P. J., Hong, T., Jarrett, T. H., Jones, D. H., Koribalski, B. S., Macri, L. M., Masters, K. L. & Springob, C. M., Nov 2017, In : Monthly Notices of the Royal Astronomical Society. 471, 3, p. 3135-3151 17 p.
3D bioengineered microtissues reveal key role of tumour microenvironment in early prostate carcinogenesis
Pereira, B. A., Lister, N. L., Niranjan, B., Lawrence, M. G., De-Juan-Pardo, E. M., Ellem, S. J., Hutmacher, D. W. & Risbridger, G. P., Jun 2018, In : Clinical Endocrinology. 89, p. 7-8 2 p.
3D Bioprinting for Tissue and Organ Fabrication
Zhang, Y. S., Yue, K., Aleman, J., Mollazadeh-Moghaddam, K., Bakht, S. M., Yang, J., Jia, W., Dell'Erba, V., Assawes, P., Shin, S. R., Dokmeci, M. R., Oklu, R. & Khademhosseini, A., 1 Jan 2017, In : Annals of Biomedical Engineering. 45, 1, p. 148-163 16 p.


Delivery Terms | Barnholdts at Studio Cim Mahony.
At Studio Cim Mahony we strive on a quick delivery, so all orders are shipped within 1-3 business days. In connection with public holidays longer delivery time may apply. Should there be delays with PostNord or DHL, Studio Cim Mahony cannot be held liable. We are currently unable to ship perfumes outside Denmark due to dangerous goods regulations.
Sweden & Germany is app. 2-4 business days – Delivery times are not guaranteed - please allow up to 7 business days.
Rest of Europe is app. 4-5 business days – Delivery times are not guaranteed - please allow up to 10 business days.
Shipments in Europe delivered by Standard Mail has the service of track and trace and a signature is required on receipt of your delivery. If you are not at home at the time of delivery the mail will leave you a note of where to pick up your parcel at your nearest postal depot.Any fees charged by customs are the sole responsibility of the customer.
DHL Express – Europe is app. 1-2 business days – You will receive text updates and tracking info and a signature is required on receipt of your delivery.
Standard Mail - Worldwide app. 5 -10 business days – Delivery times are not guaranteed - please allow up to 14 working days.
Shipments Worldwide delivered by Standard Mail has the service of track and trace and a signature is required on receipt of your delivery. If you are not at home at the time of delivery the mail will leave you a note of where to pick up your parcel your nearest postal depot. Any fees charged by customs are the sole responsibility of the customer.
DHL Express –Worldwide is app. 2- 3 business days – You will receive text updates and tracking info and a signature is required on receipt of your delivery.
All prices are shown in Euros, US Dollars and DKK and the prices do not include delivery charges. For customers within the European Union, VAT (25%) is included in all prices. For customer outside the European Union (excluding Norway and Switzerland, VAT/sales tax is not included in the price. VAT/sales tax is instead charged by customs agencies when your package reaches your country of residence. We endeavor to avoid information errors but please note that pricing errors can occur. If the correct price is less than our stated price, the correct price will be charged to you. If the correct price is higher than the price stated on our webshop, we will have to cancel your order. Then you will be contacted by e-mail.


We are set for the culmination of the Round of 16 in the UEFA Champions League, with only eight teams moving on to the Quarterfinals. The biggest match to date of the 2012/13 Champions League competition kicks off this afternoon, with Manchester United hosting Real Madrid at Old Trafford (1-1 aggregate). A well rested Christiano Ronaldo makes his first return to his old stomping grounds, after spending six seasons with the Red Devils. Real Madrid are in fine form, having won all four of their matches since their last meeting with United, including two against arch rivals Barcelona. Madrid are a counterattacking team, and perhaps the best in the World at that particular style of play. Sir Alex Ferguson is well aware of this, and will have his boys ready to spoil the party for Ronaldo and Madrid. His Manchester side have not lacked for goals all season, boasting one of the top strike forces in football right now. Veteran Paul Scholes is out due to injury, and Ryan Giggs is set to start his 1000th competitive match. This is a game the World will stop to watch, and it surely won't disappoint in terms of drama and intrigue. If you can't make it at Lunch for the match, drop in later as there will be replays throughout the evening!
In other Champions League action Borussia Dortmund host Shakhtar Donetsk, with the two sides level on aggregate 2-2. The two away goals that Dortmund carry into this tie should be difficult to overcome for the Ukrainians, not to mention the imposing home ground that Dortmund enjoys. Striker Robert Lewandowski has tallied nine goals in Dortmund's last nine matches, making him the man in form. Shakhtar feels they played well in the first leg, only conceding goals on two poor mistakes. They know it will take a mistake free game if they are to come away with a victory here. On Wednesday afternoon we have Paris St. Germain taking on Valencia at home in France. Despite having Zlatan Ibrahimovic sent off in the first leg, the French side are confident they can advance here. Valencia has their work cut out for them, as they trail 2-1 on aggregate, and will have to score at least two to advance. In our other Wednesday match a confident Juventus host Celtic, carrying a 3-0 aggregate advantage. The Scots had high hopes going into the first leg, but an early goal put them on their back foot, and Juve managed to nab two more. Odds are against the Scots, as Juventus are three years unbeaten at home in European competition, and they have never lost to a Scottish side at home. On the bright side for Celtic, they have never won in Italy, so they have a chance to end that streak here, and revenge their loss at home. Heineken and Newcastle 20oz draughts are on special for all our Champions League matches, and we are serving lunch specials during the entire competition. Don't miss any of the action, as the field is narrowed down to only eight remaining teams!
We have two feature matches on the weekend to look forward to. The first is the home opener for our Colorado Rapids, with a 4pm kick off against Philadelphia up at DSG. The Rapids played a tight game against Dallas last week, but came out on the wrong end of a 1-0 result. Long stretches of possession were a positive, but chances were limited for the Burgundy Boys. This is match two, and a positive result is needed before the team heads off to Salt Lake next week. There is an interesting storyline here, as hometown hero Conor Casey returns to DSG (in the wrong colored uniform). You can bet your bottom dollar he will want to put one in the back of the net, as the Rapids back four are well aware. DSG has to be a fortress if the Rapids want to make a return to the playoffs, what better way to start than earning a shutout at home!? As always, we will be running shuttle buses to the match from the Pub, and there will be both an early departure (for anyone wishing to tailgate) and a late departure that will get you to the ground right before kick off. Reservations and tickets are available at: www.coloradosupporters.com/reservations. Our other feature match this weekend has Manchester United facing Chelsea in the FA Cup Quarterfinals. This is one of two highly anticipated Sunday morning clashes, the other being Liverpool v Tottenham in the EPL. Don't miss any of the action, and plan on getting out in support of our hometown Club this Saturday. Cheers!
Next week we have Champions League Round of 16, our Colorado Rapids are away for a big derby against Salt Lake, and there is plenty of European and Domestic Club football to enjoy over St. Pat's weekend!


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* Initial release. Mostly harmless.

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* Docs and tests improvements

redpajama_set_name: RedPajamaGithub


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The best photos will be exhibited on Rope Street Museum!
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