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Sponsored by: LTS Lohmann Therapie-Systeme AG, QuadMedicine
Transdermal and Microneedle Drug Delivery
24th January to 25th January 2022,
Online Virtual Event , United Kingdom
SMi's Inaugural Conference: Transdermal and Microneedle Drug Delivery will take place on 24th - 25th January 2022
Post event on demand access to recorded presentations will be available to all attendees 5 working days from the end date of the event.
SMi presents the Inaugural Transdermal and Microneedle Drug Delivery Conference
24th to 25th January, 2022 | Virtual Conference: Online Access Only
SMi is proud to present the Transdermal and Microneedle Drug Delivery Conference, taking place on the 24th to 25th January 2022. Transdermal and Microneedle Drug Delivery Conference will explore real world applications of microneedles in drug delivery and strategies for device design while engaging in the latest innovations in device design and formulation with case studies from thought leaders.
The conference will consider key developments in the transdermal drug delivery field, including the innovations in microneedle technology for a COVID-19 vaccine and opportunities for development in cancer vaccine delivery, advances in microarray patches, and microneedle-based diagnostics. Key regulatory updates including guidance on classification of microneedle devices and considerations for ensuring quality will be presented by regulatory experts for a comprehensive outlook of this exciting and ever-growing field, and the importance of considering human factors in order to enhance the user experience will be presented by industry experts.
This two-day agenda offers you peer-to-peer networking with leaders in transdermal and microneedle delivery. We look forward to welcoming you to the conference in January.
Gain insight into developments in microneedles for drug delivery and diagnostics
Hear key regulatory updates from regulatory bodies including FDA and WHO on guidance for regulatory compliance
Explore new applications of microneedle technology in vaccinations
Discover advances in design and application of transdermal patches
Explore and benchmark against industry developments through case studies and real world examples in device development for microneedles
Drug-Delivery Device Developers
Microneedle Device Developers
Transdermal Delivery Developers
Microarray Patch Developers
Medical Device Engineers
Primary Packaging Material Designers
Secondary Packagers
Smart Device Developers
Training Device Developers
Device-Safety Solution Providers
Drug Developers
Transdermal Drug Product Developers
Previous attendees include:
AbbVie; Alnylam Pharmaceuticals; Amgen; Aptar Pharma; AstraZeneca; Bayer AG; BD Medical; Bd Medical-Pharmaceutical Systems; Becton dickinson; Becton Dickinson (BD); Bespak Europe Ltd; Boehringer Ingelheim; Boehringer Ingelheim GmbH; Boehringer Ingelheim Pharma GmbH & Co. KG; BSI; BSI Group; Cardiff University; CSL Behring AG; Eveon; F. Hoffman-La Roche Ltd.; F. Hoffmann-La Roche Ltd.; Ferring Pharmaceuiticals Pvt. Ltd.; FERRING PHARMACEUTICALS PVT LTD; Gerresheimer Buende GmbH; GlaxoSmithKline; GlaxoSmithKline (GSK); GSK; Haughton Design Ltd; Institute BCN Esthetics, S.L.; Ipsen; Ipsen Group; IPSEN Pharmsciences; Janssen; Janssen Pharmaceutica NV; Janssen Pharmaceutical Companies of Johnson and Johnson; Janssen Research and Development, LLC; Johnson & Johnson (Janssen Pharmaceutical); kaleo, Inc.; LEO Pharma A/S; Medicines & Healthcare Products Regulatory Agency (MHRA); MedinCell; Merck; MHRA; Minapharm Pharmaceuticals; Nemera; Nipro PharmaPackaging Germany; Novartis; Novartis – Global Drug Development; Novartis Pharma AG; Novartis Pharmaceuticals; Novo Nordisk; Novo Nordisk A/S; Novo Nordisk Pharma; Owen Mumford; PCI Pharma Services; Pfizer; Pfizer Inc.; Pfizer Ltd UK; Pfizer UK Limited; Pfizer, INC.; Regeneron Pharmaceuticals, Inc.; Rhein Minapharm; Roche; RSK-Solutions/ RSK Life Science Media; Sanofi; Sanofi SWI; TERUMO coeporation; Teva Ltd; Teva Pharmaceuticals; Teva UK; Teva, Combination Products; TUV SUD Japan Ltd.; UCB; UCB Pharma; W.L. Gore & Associates, Inc.; West Pharmaceutical Services; Zeon Corporation; Zeon Europe GmbH; Zeon Specialty Materials
8:00 Registration and Coffee
9:00 Chair's Opening Remarks
Sanjiv Sharma, Senior Lecturer in Medical Engineering, Swansea University
Dr Sanjiv Sharma received his PhD on the development of analytical methods for determination of certain pharmaceuticals and their metabolites using miniaturised separation system in 2001. On completion of his fellowship he joined the Institute of Biomedical Engineering, Imperial College London to work with Professor Tony Cass in the area of Bionanotechnology and Biosensors. Here he developed minimally invasive microneedles, from photolithographic fabrication to high throughput fabrication, taking these microneedles from the lab to the clinic . Sanjiv was involved in a NIHR (i4i) funded research project involving clinical studies in healthy volunteers and participants with T1D with renowned Endocrinologist Clinicians; Professor Desmond Johnston and Professor Nick Oliver. He has published over 50 research articles and has patents filed in Germany, UK and the United States.
Sanjiv is currently a Senior Lecturer in Medical Engineering in the College of Engineering at Swansea University. At Swansea, he is working on therapeutic drug delivery and diagnostic (theranostic) applications of polymeric microneedles.
9:10 Development of Smart Vaccine Patch for COVID19 vaccination
Repurposing microneedle technology for a COVID vaccine
Monitoring biomarkers in the skin compartment to assess efficacy of the vaccination
Microneedle patches for diagnostics and drug delivery
Evaluating advantages of microneedle technology: allowing for lower doses of the vaccine which contributes to low-cost manufacturing
Beyond the pandemic: expanding research to other diseases
9:50 The MAP Center of Excellence Regulatory Working Group: A collaborative approach to help define the regulatory pathway for MAPs
Sion Coulman, Senior Lecturer, Cardiff University
Sion is based at Cardiff University and has worked on microneedle-based delivery systems since 2002. He has been involved in the development of microneedle-based systems for both novel and established therapeutic candidates and is particularly interested in translation of the technology from laboratory prototypes to clinically useful products. He is a highly collaborative researcher with expertise that bridges the engineering, pharmaceutical science and medical research disciplines, and enjoys working in international multi-disciplinary teams. He has technical experience in both laboratory and end-user research and has parallel research interests in 3D bio-printing and capsule-based dry powder inhalers (DPIs).
A background to the MAP Regulatory Working Group (RWG)
An update on the activities of the MAP RWG, to include:
- Laboratory Developments; Developing new standardised Test Methods for MAP critical quality attributes
- Guidance; Helping to define the regulatory pathway for MAP development
10:30 Morning Coffee
11:00 GMP production of vaccine microneedles for clinical trials
Jung-Hwan Park, Chief Technical Officer, QuadMedicine, Inc.
Dr. Jung-Hwan Park, the CTO of QuadMedicine, is one of the leaders in the field of microneedles and has focused on developing microneedle-based drug delivery systems for over 20 years. Dr. Jung-Hwan Park completed his Ph.D. from Georgia Institute of Technology in biomedical engineering. Dr. Park currently holds a position as professor of Bio-Nano Technology at the Gachon University. He has also served as a president of the Korea Microneedle Research Association since 2016 and has provided consultation on microneedle product development to companies in different sectors.
Recent KFDA guidance on medical microneedle
Choosing the right vaccine for MAP technology; why is the birth dose of hepatitis B vaccine microneedle important?
Aseptic process development and quality control for hepatitis B vaccine microneedle
Analysing strategies for developing vaccine microneedle
11:20 Transdermal Delivery Systems as Drug Device Combination Products - Considerations for the biocompatibility testing program
Insight into biocompatibility evaluations supporting regulatory submissions of DDCP
Evaluating biocompatibility of Transdermal Delivery Systems / Microneedling Devices
How to comply with requirements on extractable and leachable testing
Toxicological Risk Assessment approaches for E&L
Clemens Gunther, Director, Senior Expert Nonclinical Safety, Bayer AG
Dr. Clemens Günther received his diploma in biology and doctorate for natural sciences from the Free University, Berlin-Germany.
He started his professional career in 1990 at Schering AG, Berlin-Germany.
From 2007 to 2013, Dr. Clemens Günther was Director and Head of Global Preclinical Development at Intendis GmbH, branded later-on as Bayer Dermatology.
After integration of Intendis into Bayer in 2013, he became Director Nonclinical Safety Consumer Care and later-on Senior Expert Nonclinical Safety within the Division of Bayer Pharmaceuticals.
Meanwhile Dr. Clemens Günther has gained over 30 years experience in drug development. He has been involved in nonclinical development and regulatory toxicology of small molecules, biologics, medical devices and drug device combination products in various medical indications.
12:00 Networking Lunch
13:00 Developing differentiated, transdermal forms of high-value drugs
Jake Lombardo, Co-Founder & CEO, Anodyne Nanotech, Inc
Jake has a unique combination of biomedical engineering experience and entrepreneurial acumen. He holds a B.S. of Biomedical Engineering from Union College and an M.Sc. of Innovation and Management from Tufts University. He couples this with leadership qualities developed over a lifetime of team sports to help set the direction of Anodyne.
How does the Hero Patch work? A technology overview
Current challenges in the sustained delivery of macromolecules
A new class of microneedle – the cutting edge technology behind improved drug loading
Pre-clinical data and future possibilities of the Hero Patch delivery platform
13:20 Prioritisation of microarray patches (MAPs) for vaccine delivery in low and middle-income countries
Compelling attributes of MAPs for vaccine delivery, and potential public health impact
MAPs, priority #1 as part of the Alliance Vaccine Innovation Prioritisation Strategy – methodology and rationale
The Alliance 5-year strategy and action plan for MAPs
Prioritisation of antigens for MAPs' use in low and middle-income countries
Birgitte Giersing, Team Lead, Vaccine prioritization and platforms, World Health Organization
Birgitte Giersing leads the Vaccine Prioritisation and Platform work within the Product and Delivery Research Unit, in WHO's Immunization Department. She is the secretariat for the Product Development for Vaccines Advisory Committee (PDVAC), working across a number of pathogens areas and vaccine platforms, and is the WHO focal point for the Vaccine Innovation Prioritisation Strategy (VIPS). She has approximately 20 years of vaccine product development experience, having led vaccine development programmes in the private and non-profit sector before joining WHO 6 years ago. She trained as a biochemist and performed her post-doctoral studies at the National Institutes of Health, USA in malaria vaccine development.
Marion Menozzi-Arnaud, Senior Specialist, Gavi
Within the Gavi Secretariat and Market Shaping team, Marion is leading strategic cross portfolio projects in support of defining and/or accomplishing Gavi market shaping objectives. Especially, Marion is responsible for vaccine product innovation within the Secretariat as part of the Gavi Innovation Strategy, including leading the Vaccine Innovation Prioritisation Strategy (VIPS) - a partnership between the Gavi Secretariat, WHO, UNICEF, BMGF and PATH to drive vaccine product innovation. Prior to that, Marion was the Head of Pricing and Market Access, Biosimilars at Merck, and before that she was Principal in a boutique management consulting companies specialised in the pharmaceutical industry.
14:00 A review and discussion of the 'Beyond the Needle' programme
Kerry DeMarco, DRIVe Start Program Innovation & Alliance Lead, Biomedical Advanced Research & Development Authority (BARDA)
Kerry DeMarco has been with BARDA since 2019 and currently leads the BARDA DRIVe Program & Innovation activities and runs the Beyond the Needle program. Prior to her time at BARDA, Dr. DeMarco was the Program Manager for the jointly funded BARDA/State of Texas pandemic response facility, the Texas A&M Center for Innovation in Advanced Development and Manufacturing (CIADM). Dr. DeMarco also spent over fifteen years supporting the U.S. Department of Defense Science & Technology development activities. Dr. DeMarco earned her Ph.D. in Kinesiology/Psychophysiology from the University of Maryland.
The vision and need for change
The challenges to overcome – talking logistics
14:20 PATH Microarray Patch Center of Excellence
Courtney Jarrahian, Program Advisor, PATH
Courtney Jarrahian oversees a portfolio of projects at PATH advancing vaccine and pharmaceutical packaging and delivery technologies and is co-leader of the Microarray Patch Center of Excellence. In collaboration with private- and public-sector partners, she implements projects to develop, assess, and introduce combination products and medical devices, with a focus on user-centered design, technical development, human factors evaluation, health economics, manufacturing, regulatory pathways, and commercialization. She also serves on the World Health Organization's (WHO) Delivery Technologies Working Group and is a member of PATH's Research Ethics Committee.
Overview and update from PATH's Microarray Patch (MAP) Center of Excellence, an initiative to mobilize efforts to accelerate the development of MAPs for critical vaccines and essential medicines.
How the MAP delivery technology platform can maximize its impact by meeting global public health priorities.
Evaluations of user needs, human factors, cost-effectiveness modeling, and manufacturing approaches.
15:30 Considerations for Microneedle System Development: An FDA Assessor's Perspective
Caroline Strasinger, Master Reviewer, FDA
Dr. Strasinger is a Master Reviewer in CDER's Office of Pharmaceutical Quality and is Chair of the FDA's Transdermal Drug Working Group (TDWG). As Chair she is responsible for assuring the TDWG fulfills their mission of continuously improving the scientific premises for regulating product quality as it relates to clinical performance and the public availability of transdermal drug products. She began her career at FDA in 2009 and holds a PhD in Pharmaceutics and a BS in Chemical Engineering from the University of Kentucky.
An overview of FDA perspectives on combination products, specifically transdermal and microneedle systems
Considerations for the manufacturing process and ensuring product quality of microneedle systems
Enhancing communication to move microneedle technology to the commercial market
16:10 Advances in Vaccine Adjuvants and RNA Vaccines
Derek O Hagan, Senior Advisor Vaccines, GSK
Derek O'Hagan, BPharm, MRPharmS, PhD.
I am a Senior Advisor in R&D in GSK Vaccines, since 2018, and a GSK Fellow, since 2019. Prior to this I was the Global Head of Discovery Support and New Technology in GSK Vaccines. Until 2015, I was the Global Head of Vaccine Chemistry and Formulation Research for Novartis Vaccines. I have extensive experience on Vaccine Adjuvants, including R&D of those included in licensed products. I was a key member of the Team that established the program on RNA vaccines in Novartis, Cambridge, in 2009. I served on the Board of Scientific Advisors for the Controlled Release Society and I am a Fellow of the American Association of Pharmaceutical Scientists. I was awarded the Conference Science medal of the Royal Pharmaceutical Society of Great Britain in 1997, and the Young Investigator Research Achievement Award of the Controlled Release Society in 1999. I was also named as the 'most inventive scientist' in Chiron in 2004.
Licensed vaccines with adjuvants
RNA vaccines
Discovery of next generation adjuvants
16:50 Chair's Closing Remarks and Close of Day One
9:10 Microneedles for oral delivery
Ester Caffarel-Salvador, Associate Director, Regenerative Medicine, LEO Pharma A/S
Dr. Ester Caffarel-Salvador is a multidisciplinary scientist with a background in biotechnology and biochemistry. She was recognized by the MIT technology review with the Innovators under 35 award in 2019 and the Nova Talent award in 2021. As a postdoc in Professor Robert Langer's laboratory at MIT, she developed a novel pill design to administer insulin and other macro-molecules via oral delivery in collaboration with Novo Nordisk.
Dr. Caffarel-Salvador is now an Associate Director of Regenerative Medicine at LEO Pharma. She is passionate about advocating on career development for women in science and is an advisor and mentor at various academic and entrepreneurial programs, both locally and internationally.
Challenges of delivering to the gastrointestinal tract
Key device features for successful oral delivery
The landscape for oral drug delivery and microneedles
Patient perceptions of microneedles in the oral mucosa
9:50 Human centered design of microneedle products
James Birchall, Professor of Pharmaceutical Sciences and Deputy Head of School, Cardiff University
James Birchall is Professor of Pharmaceutical Sciences and Deputy Head of the School of Pharmacy and Pharmaceutical Sciences, Cardiff University. Professor Birchall graduated from Bath University in 1993 and completed his PhD researching drug and DNA delivery systems in 1998 (Cardiff University). Current research includes pulmonary drug delivery and microneedle delivery of molecules, macromolecules, vaccines, auto-antigens and cells into skin for therapeutic, immunisation or immunotherapy applications.
Professor Birchall has acted as Associate Editor of Critical Reviews in Therapeutic Drug Carrier Systems, a member of the Editorial Board of Expert Review of Medical Devices, a temporary advisor to the WHO and an expert advisor to the British Pharmacopoeia and conducted research funded by the EU, DFID, Bill and Melinda Gates Foundation, NIH, Wellcome Trust, EPSRC, MRC, Welsh Government, Royal Society, Innovate UK and various charities and pharmaceutical companies.
User studies and human factors in microneedle product development
Addressing challenges in contraception technologies in low and middle income countries
Evaluating the usability and acceptability of a microneedle-based contraceptive
11:00 Nanoengineered microneedle arrays and their applications
Ryan Donnelly, Chair in Pharmaceutical Technology, Queen's University Belfast
Professor Ryan Donnelly holds the Chair in Pharmaceutical Technology at Queen's University Belfast and is Director of QUB's interdisciplinary research programme Materials & Advanced Technologies for Healthcare (MATCH). His personal research is centred on design and physicochemical characterisation of advanced polymeric drug delivery systems for transdermal and intradermal drug delivery, with a strong emphasis on improving patient outcomes. He is currently developing a range of novel microneedle technologies through independent research, but also in collaboration with several major pharma partners. He has obtained substantial UK Research Council, charity and industrial funding and authored over 300 peer-reviewed publications (H-index = 58), including 6 patent applications, 6 textbooks, 23 book chapters and approximately 250 full papers. He has been an invited speaker at numerous national and international conferences. Professor Donnelly is Europe/Africa Editor of Drug Delivery & Translational Research and the Controlled Release Society's Communications Chair. He has won the Academy of Pharmaceutical Science's Innovative Science Award (2020), Evonik's Resomer Award (2018), the Controlled Release Society's Young Investigator Award (2016), BBSRC Innovator of the Year and the American Association of Pharmaceutical Scientists Pharmaceutical Research Meritorious Manuscript Award (2013), the GSK Emerging Scientist Award (2012) and the Royal Pharmaceutical Society's Science Award (2011).
The enhanced delivery of long-acting HIV medicines
Plasmonic photothermal therapy of basal cell carcionomma
11:40 Transdermal and Microneedle Drug Delivery – Regulatory requirements in the EU
Janet Koenig, German CHMP Alternate, Head of the Unit Anaesthesiology, Algesiology, Rheumatology, Pneumology, ENT, German Federal Institute for Drugs and Medical Devices (BfArM)
Janet Koenig is the Head of Unit Anaesthesiology, Algesiology, Rheumatology, Pulmonology, ENT in the Division Licensing at the German Federal Institute for Drugs and Medical Devices (BfArM). Mrs. Koenig is also the German alternate member of the Committee for Medicinal Products for Human Use (CHMP) She received her M.D. at University of Goettingen Germany (1998) and her Board Certificate in Surgery at University Hospital of Bonn, Germany.
General requirements for topical products in the context of a regulatory submission
Aspects to consider with respect to applications with Microneedle technology
Transdermal and Microneedle Drug Delivery Systems in paediatrics
13:20 Enabling More Efficacious and Accessible Vaccines with the MIMIX Patch Platform
Michael Schrader, CEO, Vaxess Technologies
Michael Schrader is the CEO of Vaxess, an NIH and VC-backed company bringing vaccines out of the clinic and into patients' lives with the MIMIX Smart Release platform. MIMIX combines ease of administration with efficacy enhancements enabled by the "mimicry" of natural infections. The company has a pipeline of vaccines under development, including a world-first COVID + Influenza vaccine. Prior to Vaxess, Michael spent time at Google and Honda where he helped bring a range of products to market and earned more than fifteen patents. Michael received his B.S. in Mechanical Engineering from Purdue University and his M.B.A. from Harvard.
Introduction to the biology of sustained intradermal delivery
Introduction to the MIMIX sustained intradermal delivery platform
Pre-clinical data review
Manufacturing and clinical trial program status
14:00 Tissue Role in MAP Insertion Dynamics
Tycho Speaker, Director, Drug Delivery and Biomaterials, AbbVie Ltd
Tycho Speaker is currently Director, Drug Delivery and Biomaterials at AbbVie. He holds a doctorate in physical chemistry, which is the basis for a career spanning a variety of manufacturing and formulation roles. Work toward treatment of a rare skin disorder (Pachyonychia Congenita) included the development of a novel dissolvable microneedle technology, among a range of other patents and innovations in various stages of commercialization.
Discussion of complex physical phenomena influencing MAP insertion
Tissue-specific considerations in development of a delivery system
Path to clinical studies and model selection
14:40 Advanced microneedle patches for drug delivery
Mark R Prausnitz, Regents Professor, Georgia Institute of Technology
Mark Prausnitz is Regents' Professor and J. Erskine Love, Jr. Chair of Chemical & Biomolecular Engineering at the Georgia Institute of Technology. He earned a BS degree from Stanford University and PhD degree from MIT, both in chemical engineering. Dr. Prausnitz and colleagues carry out research on drug delivery using microneedles, lasers, ionic liquids and other microdevices for transdermal, ocular and intracellular delivery of drugs and vaccines. Dr. Prausnitz teaches courses on engineering calculations and pharmaceuticals. He has published almost 300 journal articles and has co-founded five start-up companies including Micron Biomedical and Clearside Biomedical.
Perspective on microneedle field as a whole
Novel microneedle patch designs
Case study on microneedle patch for drug delivery
15:50 Vaxxas HD-MAP Update
Tom Lake, SVP, Strategic Alliances and Commercialization, Vaxxas
Tom Lake, Senior Vice President, Strategic Alliances & Commercialization, Vaxxas. Tom Lake supports new businesses that improve access to immunizations. He brings vaccine industry experience in Product Development, Manufacturing, and Commercialization.
Pre-clinical and Clinical Studies
Insights into Vaxxas' needle-free vaccination technology
Manufacturing of Vaxxas' HD-MAP
16:30 Panel Discussion: Future outlook of transdermal drug delivery systems
Recent advances of microneedles for biomedical applications
Commercial opportunities in developing transdermal delivery systems
Overcoming challenges in scale up of manufacturing
Future uses of microneedles in pandemics: what would it take to make the technology ready?
Is the market ready for microneedle patch technology? Weighing the benefits and costs of transdermal delivery
17:10 Chair's Closing Remarks and Close of Day Two
Birgitte Giersing
Team Lead, Vaccine prioritization and platforms, World Health Organization
Caroline Strasinger
Master Reviewer, FDA
Courtney Jarrahian
Program Advisor, PATH
Derek O Hagan
Senior Advisor Vaccines, GSK
Ester Caffarel-Salvador
Associate Director, Regenerative Medicine, LEO Pharma A/S
James Birchall
Professor of Pharmaceutical Sciences and Deputy Head of School, Cardiff University
Janet Koenig
German CHMP Alternate, Head of the Unit Anaesthesiology, Algesiology, Rheumatology, Pneumology, ENT, German Federal Institute for Drugs and Medical Devices (BfArM)
Jung-Hwan Park
Chief Technical Officer, QuadMedicine, Inc.
Mark R Prausnitz
Regents Professor, Georgia Institute of Technology
Sachin Dubey
Head of Drug Product and Analytical Development, Ichnos Sciences, SA
I am presently working with Ichnos Sciences, Switzerland (A part of Glenmark Pharmaceuticals SA, Switzerland) and heading three major functions for the company – formulation, analytical, and drug product development groups. I have more than 15 years of experience in this area with > 9 years in an industrial setting (with previous global experience with Novozymes A/S Denmark and Glenmark Pharmaceutical SA Switzerland). Twelve products developed by me and my team are currently in clinical trials. These products are in different markets including the USA, EU, and Asia – this gave us very rich hands-on experience. In addition, I have 18 PCT patents, 24 publications in high-impact journals like Trends in Biotechnology, Journal of Controlled Release, Molecular Pharmaceutics, etc., 7 book chapters, and have been invited speaker on the topic in several international conferences (> 50). Industry and academia have equally recognized my contribution with 20 research awards including prestigious industry awards from Glenmark (Best innovation team – won twice), Merck (Innovation cup), Novartis (International bio camp), and the Swiss Society of Pharmaceutical Sciences (Best publication).
Sanjiv Sharma
Senior Lecturer in Medical Engineering, Swansea University
Sion Coulman
Senior Lecturer, Cardiff University
Tom Lake
SVP, Strategic Alliances and Commercialization, Vaxxas
Tycho Speaker
Director, Drug Delivery and Biomaterials, AbbVie Ltd
Clemens Gunther
Director, Senior Expert Nonclinical Safety, Bayer AG
Jake Lombardo
Co-Founder & CEO, Anodyne Nanotech, Inc
Kerry DeMarco
DRIVe Start Program Innovation & Alliance Lead, Biomedical Advanced Research & Development Authority (BARDA)
Marion Menozzi-Arnaud
Senior Specialist, Gavi
Michael Schrader
CEO, Vaxess Technologies
Ryan Donnelly
Chair in Pharmaceutical Technology, Queen's University Belfast
Sebastian Braun
Head of Formulation Development, Head of Manufacturing MAP, LTS Lohmann Therapie-Systeme AG
Dr. Sebastian Braun worked in the field of transdermal and dermal drug delivery for 15 years at different companies. A molecular biologist by training with a PhD in analytical chemistry and molecular biology, he started his career at a transdermal drug delivery company with a fundamental understanding of the biological workings of the skin. Spending the last 15 years at different transdermal and dermal drug delivery companies in various positions including head of formulation development, head of manufacturing and head of science and technology, he is now focused on microneedle development and manufacturing.
View details LTS Sponsors http://ltslohmann.de/en/
LTS Lohmann Therapie-Systeme AG is a leading technology company that develops and manufactures innovative drug delivery systems such as Transdermal Patches ("TTS") and Oral Thin Films ("OTF") for the pharmaceutical industry. LTS maintains its leading position through the continuous refinement of its core TTS and OTF technologies and by advancing emerging drug delivery technologies, including Micro Array Patches (MAP) for the intradermal delivery of large molecule, biological actives and vaccines.
Founded in 1984, LTS operates today from two sites in Andernach, Germany and West Caldwell, NJ, USA and a representative office in Shanghai, China.
View details QuadMedicine Sponsors https://www.quadmedicine.com
WE CREATE BETTER TREATMENT TECHNOLOGY TO MAKE OUR LIVES HEALTHIER AND EASIER.
QuadMedicine is a CDMO company, presenting a medical microneedle platform upon request from pharmaceutical companies. We have built our own sophisticated microneedle production technology based on equipment and tool design capabilities. Also, QuadMedicine is specialized in formulation technology and drug coating technology with minimal drug loss. We can enhance drug stability and efficacy during manufacturing and storage. Above all, QuadMedicine is the first company in the world to establish a microneedle production facility that meets the requirements for vaccine manufacturing. In this facility, most vaccines and synthetic drugs can be handled.
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Key Media Partners
View details evvnt Ltd Key Media Partners http://www.evvnt.com evvnt enables people all over the world to fill their events utilising the most effective event listing sites on the web. Every minute, with little more than a click, more events and conferences appear in listings, in search engines and on mobile - discoverable by both category and location. With next to no effort customers of evvnt get better attendance, while consumers find events they previously had no idea existed. To date customers in 70 countries worldwide have submitted over 500,000 thousand event listings, created over 300,000 live links, and generated 1 million clicks to ticketing and registration pages. Learn more at www.evvnt.com
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View details pharmanews hq Key Media Partners http://http://pharmanewshq.com MedChemNet provides a unique and unparalleled platform for the medicinal chemistry community to share insights, discuss the latest research, and help move the field forward. MedChemNet covers all aspects of the drug discovery pipeline, from target identification and validation, through computer aided drug design (CADD), synthesis, screening and other biophysical techniques, to development of novel lead compounds and pre-clinical in vivo proof of concept. We also cover the design of synthetic drug delivery carriers and ADME/toxicology studies, as well as intellectual property and economic related issues. Website: Welcome to Pharma News HQ, the journal dedicated to the pharmaceutical and biopharmaceutical contract services. With regular sections on contract manufacturing, contract research, contract packaging, formulation/development services, contract analytical testing, APIs, stability testing, clinical research and other areas, we bring the most complete coverage of trends and issues in the industry. Pharmanewshq.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production.
View details pharmaphorum Key Media Partners http://www.pharmaphorum.com pharmaphorum drives innovation within the pharmaceutical industry, by bringing healthcare together through a suite of media services that help produce and disseminate thought leadership, combined with an online platform for communicating messages to a global audience.Visit www.pharmaphorum.com
View details Pharmiweb Key Media Partners http://www.pharmiweb.com Established in October 2003, PharmiWeb Solutions is an energetic, innovative provider of web-based solutions for the pharmaceutical sector, with customers such as AstraZeneca, Roche, Servier Laboratories, and Merck With solutions in three key areas: Online Publishing, e-Business and Mobile Computing, we deliver connectivity – between people and applications – unlocking islands of data and knowledge. We own some of the sector's most innovative Online Publications: PharmiWeb.com, HospitalPharma.com and Detail-Direct.com. We are actively developing solutions for Mobile Computing platforms. For example, our PharmiTabTM e-pharmacy solution runs real-time patient data and prescribing transactions in a busy hospital environment, on a TabletPC, wireless client/server platform. e-Business solutions range from e-Detailing, to Online Market Research, all designed to increase reach, increase sales, and to reduce administration and costs.
View details Technology Networks Key Media Partners http://go.technologynetworks.com/subscribe-to-newsletters Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com
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Microneedles - tiny objects that make a huge impact
Online Virtual Event
Online Virtual Event , Online Virtual Event , United Kingdom
Preliminary Attendees
SPEAKER INTERVIEW - Dr. Sebastian Braun, LTS Lohmann TherapieSysteme AG
SPEAKER INTERVIEW - Michael Schrader, Vaxess Technologies
Speaker Interview with Kerry Demarco, Biomedical Advanced Research & Development Authority (BARDA)
Speaker Interview - ESTER CAFFAREL-SALVADOR, LEO Pharma A/S
Speaker Interview - Mark Prausnitz, Georgia Institute of Technology
Conference Co-Chair Letter
Chair & Speaker Biographies
Transdermal and Microneedle Drug Delivery 2022 Brochure
http://ltslohmann.de/en/
QuadMedicine
https://www.quadmedicine.com
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Founded in 2000, Technology Networks is established as the leading news provider for life science and drug discovery professionals. In addition, we provide unique content including webcasts, videos, application notes and posters from recent conferences. Our portfolio now includes around 30 focussed scientific communities, all of which are accessible free of charge within TechnologyNetworks.com
pharmanews hq
http://http://pharmanewshq.com
MedChemNet provides a unique and unparalleled platform for the medicinal chemistry community to share insights, discuss the latest research, and help move the field forward. MedChemNet covers all aspects of the drug discovery pipeline, from target identification and validation, through computer aided drug design (CADD), synthesis, screening and other biophysical techniques, to development of novel lead compounds and pre-clinical in vivo proof of concept. We also cover the design of synthetic drug delivery carriers and ADME/toxicology studies, as well as intellectual property and economic related issues. Website: Welcome to Pharma News HQ, the journal dedicated to the pharmaceutical and biopharmaceutical contract services. With regular sections on contract manufacturing, contract research, contract packaging, formulation/development services, contract analytical testing, APIs, stability testing, clinical research and other areas, we bring the most complete coverage of trends and issues in the industry. Pharmanewshq.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production.
evvnt Ltd
http://www.evvnt.com
evvnt enables people all over the world to fill their events utilising the most effective event listing sites on the web. Every minute, with little more than a click, more events and conferences appear in listings, in search engines and on mobile - discoverable by both category and location. With next to no effort customers of evvnt get better attendance, while consumers find events they previously had no idea existed. To date customers in 70 countries worldwide have submitted over 500,000 thousand event listings, created over 300,000 live links, and generated 1 million clicks to ticketing and registration pages. Learn more at www.evvnt.com
http://www.pharmaceutical-technology.com
Pharmaceutical-technology.com is the only website focusing specifically on issues relevant to pharmaceutical professionals working with technology, be it development, engineering, IT or production. Pharmaceutical-technology.com brings you the latest in industry projects and updates, along with the news, views and trends that leading professionals – from senior executives to manufacturing managers and heads of procurement – require to stay on top of their field.
Pharmacircle
http://www.pharmacircle.com
PharmaCircle is an innovative knowledge management company serving the current and future global leaders in the Pharmaceutical and Biotechnology related industries. PharmaCircle is a one stop information and analysis source for pipeline, products, clinical trials, drug delivery technologies, deals and acquisitions, company financials, venture capital investments, product sales, pharmaceutical services, news, patents and more….
pharmaphorum
http://www.pharmaphorum.com
pharmaphorum drives innovation within the pharmaceutical industry, by bringing healthcare together through a suite of media services that help produce and disseminate thought leadership, combined with an online platform for communicating messages to a global audience.Visit www.pharmaphorum.com
Pharmiweb
http://www.pharmiweb.com
Established in October 2003, PharmiWeb Solutions is an energetic, innovative provider of web-based solutions for the pharmaceutical sector, with customers such as AstraZeneca, Roche, Servier Laboratories, and Merck With solutions in three key areas: Online Publishing, e-Business and Mobile Computing, we deliver connectivity – between people and applications – unlocking islands of data and knowledge. We own some of the sector's most innovative Online Publications: PharmiWeb.com, HospitalPharma.com and Detail-Direct.com. We are actively developing solutions for Mobile Computing platforms. For example, our PharmiTabTM e-pharmacy solution runs real-time patient data and prescribing transactions in a busy hospital environment, on a TabletPC, wireless client/server platform. e-Business solutions range from e-Detailing, to Online Market Research, all designed to increase reach, increase sales, and to reduce administration and costs.
World Pharma Today
http://www.worldpharmatoday.com
World Pharma News
http://www.worldpharmanews.com/


In case you are not ready to rely on your service provider with the full software development lifecycle, it may be more comfortable for you to try outsourcing a discrete, but nevertheless vital, part of your project – testing.
Once you've decided to follow the outsourced software testing route, mind the following things you are likely to meet on your way and some valuable tips you'll need.
Your internal people won't be happy to see you've brought an outside service vendor to test their systems. But if the vendor's doing a great job, the attitude will change for the better. Make it clear for your internal staff that these outsiders won't replace them, but they have much to teach your employees.
The right provider of testing services can serve as a key to offshore expertise. Be prepared that if your project is too large, your testing provider may consider the opportunity of further offshoring some part of it if this is profitable for their and your companies.
It's a bad idea to ask your code development provider to do your testing. QA needs objectivity towards the written code, that's why if you ask one provider to build anything and then to check how qualitative it is, the results will be the matter of their reputation, not the matter of product quality.
Your plans for testing are better declared up front, along with your app specifications. Many companies still develop first and test last which leads to the wrong attitude to QA and vague testing goals. Rather than laying blame, testing aims to quantify test results to the customer and educate programmers in order to let them move to the next app lifecycle phase with checks and balances.
Multi-vendor scenarios demand tight management and proper service level agreements. Besides, it's important that individuals involved are diplomatic. When it comes to deciding whose fault it is that something goes wrong in the process of your cooperation with a testing provider, the justice should be found in the things agreed upon and documented from the start.
If you have poorly documented systems, expect your service provider to need more time to grow working speed. This in turn means you'll have to pay higher fees. After a testing vendor examines your app's complexity and documentation and training amount that may be necessary, negotiate on the time and fees properly.
The QA part of your project budget is variable. How much budget resources the testing will soak up depends on your app nature, required functionality and security measures. Testing takes from a week to several months, therefore you should mind your priorities and select the most appropriate business model for them.
Consider the mentioned tips to get well prepared for challenges testing outsourcing can hide for your business.


text:
"""
views.py

URL route handlers

Note that any handler params must match the URL route params.
For example the *say_hello* handler, handling the URL route '/hello/<username>',
  must be passed *username* as the argument.

"""
from flask import request, render_template, flash, url_for, redirect
from flask_cache import Cache
from application import app
from models import Post
from datetime import datetime
import urllib2
import json

# Flask-Cache (configured to use App Engine Memcache API)
cache = Cache(app)

def request_json(url):
    req = urllib2.Request(url)
    response = urllib2.urlopen(req)
    page = response.read()
    return json.loads(page)

def warmup():
    """App Engine warmup handler
    See http://code.google.com/appengine/docs/python/config/appconfig.html#Warming_Requests

    """
    return ''

def home():
    return "Sit tight! I'll be up and running soon enough", 200

def scrape():
    top = request_json('https://hacker-news.firebaseio.com/v0/topstories.json')[:100]
    for index, story_id in enumerate(top):
        story = request_json('https://hacker-news.firebaseio.com/v0/item/{}.json'.format(story_id))
        rank = index + 1
        existingPost = Post.query(Post.url == story.get('url')).fetch()
        if existingPost:
            existingPost = existingPost[0]
            existingPost.times.append(datetime.now())
            existingPost.ranks.append(rank)
            existingPost.highest_rank = min(rank, existingPost.highest_rank)
            existingPost.put()
        else:
            newPost = Post(
                time = story.get('time'),
                post_id = story.get('id'),
                url = story.get('url'),
                highest_rank = rank,
                ranks = [rank],
                times = [datetime.now()]
                )
            newPost.put()

    return 'woohoo', 200

redpajama_set_name: RedPajamaGithub


Through agricultural education, students are provided opportunities for leadership development, personal growth and career success.
Placement: Get a job or internship on a farm or ranch, at an agriculture-based business, or in a school or factory laboratory.
Exploratory: Explore careers in agriculture by attending an agriculture career fair, or creating a report or documentary on the work of a veterinarian.
Career opportunities abound within today's agriculture industry. Career Development Events (CDEs) help students develop the abilities to think critically, communicate clearly, and perform effectively in a competitive job market.


A 19-year-old man has been arrested this evening on suspicion of murder. It is understood he was arrested in Grays town centre just before 5pm.
'Tattoo John,' whose real name was John Hicks, was found with a head injury in London Road in the town in the early hours of Tuesday (July 3).
He was taken to hospital after police officers were called at 12.50am but sadly died this afternoon (July 4).
Senior investigating officer, detective chief inspector Daniel Stoten, of the Kent and Essex Serious Crime Directorate said: "We are keen to speak to anyone with information about the injuries John sustained before his death.
A forensic post mortem examination is due to take place tomorrow (July 5).


Here is a high-performance triathlon shoe designed to take you from the first to the second transition zone as fast as possible. The brand-new Tri X-Lite II is stiffer and its hook and loop fasteners won't loosen after 5 km of riding. Improved ergonomics allow you to focus on one thing only: getting the best possible bike split.


Download Song Hilang Ost Cinderella Instrumental Audio file type: MP3 320 kbps.
Gratis Download Hilang Ost Cinderella Instrumental Mp3 Song 320 Kbps. Baixar Indir Music Hilang Ost Cinderella Instrumental Video.


text:
Q: Is there a way to pipe the `hdiutil create` into a raw stream without needing to store it first? I would like to do something like
hdiutil create dest_file.dmg -srcdevice /dev/disk3 | curl -TX - PUT \
    -H "Authorization: Token" \
    --output /dev/null \
    "https://uploadlink.com"

so that I do not need to store dest_file.dmg first in order to upload (as I don't have enough diskspace for this). Is there an option to stream the file and upload using hdiutil create?

A: It doesn't immediately seem possible, no.
The hdiutil tool itself has no option to write to stdout.
It cannot be tricked by using /dev/fd/1 as the output file either.
Creating a named pipe using the mkfifo command doesn't work, as the hdiutil checks for the existence of the file before starting.
In this case it is possible easier for you to simply stream over the raw disk contents, and then convert it to a dmg on the receiving end (depending on which utilities you have available there). In your case it is a simple dmg file, so converting it is just a matter of adding a small footer structure to the end of the file after transferring it.
You could transfer the raw data using a command like:
dd if=/dev/rdisk3 bs=1m | curl -TX - PUT -H "Authorization: Token" --output /dev/null "https://uploadlink.com"

redpajama_set_name: RedPajamaStackExchange


• Olive oil - 3 teaspoons.
• Fennel seeds powder - 1/4 tea spoon.
• Capsicum (chopped) - 3 numbers.
• Tomato - 8 numbers.
• Basil leaves - 1 tea spoon.
Boil tomatoes bygiving gashes in hot water for 30 seconds then put it in cold water and peel off the skin.
Then chop the half of the tomatoes finely and remaining tomatoes make them paste.
Saute garlic in olive oil, add bell pepper and saute for few more seconds.
Then add chopped tomato, tomato paste of fresh tomatoes, salt and a pinch of sugar and cook till soft and juices evaporate to the right consistency, add basil, fennel seeds powder (optional).
Ready to use as topping on pizza.
Generally a mix of tomato paste, water, parmesan cheese, and garlic blended well together makes this flavorful homemade pizza sauce.
The next time you're making homemade pizza, you might as well make some sauce too.
So pizza is Indian because women used to put origano in their hair ??
LOL omg. Bible, Quran, Bhagavad Gita, and Kamasutra?? What a combination! ?
I thought pizza was Mediterranean? ?
IHope the Quran part wasn't a jokePlus u have so many subscribers, what about a better camera??
ohhhh....... come on!! bible quran and bhagavathgita?? combined with kamasutra ?????
The tomato paste looked like blood?
the story made no sense to me lol?
where r these marjoram basil and oregano herbs available r they to be used dry or fresh?
You don't need kama sutra, my friend, trust me. If someone has genius cooking skills like you, they'll follow you from the dining room straight to the bedroom.?
Good sauce but talk less and cook more boss ?


text:
Who Was Originally Scheduled To Win The WWE Championship At Day 1?
• Who Was Originally Scheduled To Win The WWE Championship At Day 1?
According to the Wrestling Observer, Seth Rollins was originally scheduled to win the WWE Championship at the Day 1 premium live event.
However, this plan got changed once Universal Champion Roman Reigns got pulled from the show and Brock Lesnar got added to the WWE Championship match.
WWE Officials then decided to put the WWE Title on Lesnar, because The Beast is currently the #1 babyface in WWE.
There was a report that the WWE On FOX Twitter account accidentally posted a graphic which showed the result being Big E retaining the WWE Championship, but that graphic was just a mistake.
Rollins is now scheduled to face Roman Reigns for the Universal Championship at Royal Rumble 2022, while Lesnar will defend the WWE Championship against Bobby Lashley.
Also Read: Former WWE Star Debuts In IMPACT Wrestling, Gets Hurt During A Brawl
WATCH: Sable's (Brock Lesnar's Wife) Super Hot Buns:
• On This Day In Wrestling History (January 10, 1999) – ECW Guilty As Charged '99
On this day in Pro Wrestling history on January 10, 1999, Paul Heyman's Extreme Championship Wrestling aired 'ECW Guilty As Charged 1999' LIVE on PPV from the Millennium Theatre in Kissimmee, Florida.
This was one of the very few ECW events that featured Sid Vicious (WWF's Sycho Sid / Sid Justice) and Nicole Bass.
– Three-Way: Hardcore Chair Swinging' Freaks defeated The F.B.I. and Danny Doring & Amish Roadkill
– Yoshihiro Tajiri defeated Super Crazy
– Sid Vicious defeated John Kronus
– The Dudley Boyz defeated New Jack and Spike Dudley
– ECW World Television Championship: Rob Van Dam (c) defeated Lance Storm
– Stairway To Hell: Justin Credible defeated Tommy Dreamer
– ECW World Heavyweight Championship: Taz defeated Shane Douglas (c)

redpajama_set_name: RedPajamaCommonCrawl


Jamie Mueth is a motivated, eager and ambitious Escrow Officer. Jamie has over 16 years of industry experience including title exposure.
Jamie takes pride in providing superior customer service and attention to detail. She is truly committed to closing your transaction with the highest level of professionalism and service.
With a Marketing degree, title and escrow background, and drive to deliver exceptional service, she is looking forward to working with you on your next transaction!
Jamie handles every transaction as though it is her own. I can't even imagine a better experience for me or my clients. No question ever goes unanswered and she handles the stressful situations with ease and confidence.
She was very easy to work with and followed up on questions and emails promptly!
Jamie did an awesome job on my last transaction! She was always one step ahead of me anytime I needed to get something updated and she ensured we could close when we needed to. Jamie did a great job of explaining all of the paperwork and made sure all of the questions were answered. I appreciate the prompt responses she and the great team over at Fidelity National Title provided!!
Jamie Mueth does her job like I run my business, nothing is too hard to do and it's never too late in the day to get something started. Everything is done ahead of time and handled pleasantly and efficiently.
Jamie is literally the nicest and fastest Escrow Officer I have had the Pleasure of working with. Jamie responds to email with in minutes to supply the needed information. Total Pleasure working with You Jamie!! See you on the next one!!
Jamie was truly amazing to work with! She was extremely prompt, friendly, and professional. My clients felt very comfortable when they went to sign their loan documents with her, and had only great things to say about her. She made my loan team's job so easy, because she is knowledgeable and well versed in her profession. I highly recommend Jamie as an Escrow Officer, and I look forward to working more with her again on future transactions.
Jamie went above and beyond to assist with my clients' transaction!
Despite the holidays, government shutdown, and last-minute insurance changes, she was quick to accommodate; she sacrificed her Saturday morning to sign, was fast to respond to e-mails, and even drove to my client's place of work to grab a needed signature on New Years Eve.
I cannot recommend her enough! She is knowledgeable, amiable, and a problem sovler.
Jamie worked very diligently from the beginning to the end of the closing. The buyers were out of state and she accomplished that signing. She worked on various payoffs, and our mortgage holder. She accommodated us on document signing. Always pleasant and professional.
The goal is to process and close on time and all was accomplished.
She did an exceptional job.
Jamie has exceeded all my expectations. Returns all calls emails and texts. Every chance I get to use Jamie i will.
We purchased a home in Idaho while out of State. Jamie was always right on top of the process and kept us updated along the way. Communication is key and she was slways there to answer questions and was also very accommodating when remote signatures were needed. I will refer business to Jamie and her team in the future. A good Title agent is key to a successful close.
Jamie is fantastic! She promptly addressed all issues that came up, sought anwsers for many questions and streamlined the transaction. What really makes Jamie stand out is her heart - for the customer, for the experience and for the industry. I absolutely recommend Jamie to anyone looking for an escrow officer.


text:
World music matters Podcast Podcast
Nakhane: the South African songbird soaring high
By Alison Hird, Isabelle Martinetti
Released on 05-04-2018 Modified 06-04-2018 to 12:54
You Will Not Die, Nakhane's second solo album BMG Rights Mgmt France SARL
Download this edition
South African singer-songwriter and actor Nakhane burst onto the European scene in December 2017 at the TransMusicales festival in the French town of Rennes where he was given carte blanche five nights in a row. The LGBTQ trailblazer with the heavenly voice seems set for stardom. He talks to RFI about starring in the award-winning but controversial film The Wound and "queering" religion on his new album You will not die.
"The song You will not die is about abandonement," says Nakhane, "because I was raised by my aunt and her husband and it's looking at my biological parents and saying 'you know what I didn't die. It hurt, messed up with me psychologically maybe, but I didn't die. Look at me now'."
Nakhane grew up in the Presbyterian church in Port Elisabeth. For years he tried to hide his homosexuality but finally embraced it in his early 20s. He was ex-communicated in 2014.
"[The song's] also about apostacy, me leaving the church, and being able to look at it now and going 'this doesn't hurt anymore'."
"Trauma but make it fashion!" he says. "It hurts, but at least I got a song out of it."
Nakhane at TransMusicales festival in Rennes. ©Bastien-Brun
Existing in a space that doesn't want me
The song Interloper, about jealousy, is accompanied by a glam rock video in which the singer is surrounded by hoards of adoring fans dressed in church robes struggling to caress his bare chest.
"I wanted to show a sense of power [...] playing with this idea of a gay Messiah. Or this whole idea of being desired to the point that people consume you."
Subverting the religion that rejected him? Not exactly.
"I'm queering religion, inserting queerness into spaces where queerness is sometimes seen as the other or something that's perverse," he explains. "And I'm allowing myself to exist in a space that does not want me. Putting myself in a place of power, a place where I don't need someone to clap their hands for me or accept me."
On the song Clairvoyant he explores an adult gay relationship. The video shows a gay couple hanging out at the weekend, embracing, arguing. It's a "nuanced approach you don't often find in pop", an attempt to "normalise gay relations" says Nakhane.
The Wound
Nakhane has also recently won four awards for his leading role in The Wound, a film exploring the taboo of being a young gay man in the Xhosa community to which he belongs.
The film was banned for a while and led to months of protests all over the Cape. The singer received death threats and is now based in London.
Watch the video to hear why he believes the film's detractors are wrong.
Follow Nakhane on facebook
Mid-East Junction
Israeli band Orphaned Land spreads message of peace across Middle East
Africa: Stories in the 55
Musician examines his integrity in Nigerian magical realism novel Taduno's Song
Tanzania music ban - protecting cultural norms or limiting freedom of expression
Cimafunk brings Afro-Cuban funk therapy to France
When Erick Iglesias Rodríguez discovered the power of groove, he quit medical school, went to Havana and morphed into Cimafunk. His 2017 album Terapia (Therapy) aims …
Lemma brings women artists from the Algerian desert to the stage
Franco-Algerian singer Souad Asla grew up in Béchar in south west Algeria listening to, and loving, the region's traditional repertoires. While women have played a role …
Yemeni-style hip hop from A-WA sister trio
A-Wa sing electronic-infused versions of Yemenite folk songs in Arabic. They proudly defend their Israeli Yemenite identity on their second album Bayti Fi Rasi, inspired …
Kenyan singer JS Ondara keeps the American dream alive
JS Ondara began writing songs as a kid in Nairobi, obsessed with American artists like Bob Dylan and Neil Young. His dream of following in Dylan's footsteps became reality …
Serpentist Michel Godard meets Alim Qasimov: spellbinding
French avant garde jazzman Michel Godard is one of the world's leading players of the serpent, a Renaissance wind instrument, ancestor of the tuba and which was first …
Sarah Lenka sings legacy of African-American women's blues
After a third album I don't dress fine in tribute to American blues singer Bessie Smith, French jazz singer Sarah Lenka has released Women's Legacy. Her subtle rendition …
Omo Bello: the Nigerian soprano's star is rising in France
Omo Bello was born in Nigeria but trained and found success here in France. She's recorded a solo album of Mahler's Des Knaben Wunderhorn, was nominated for a Victoires …
Deming does migrant detention …
Payment in plastic boosts education, …
World Music Matters logo | iStockphoto
Paris is a hub for musicians from all over the world. Our weekly show is a forum for sharing that music, and exploring its emotional impact. World Music Matters is hosted by RFI's Alison Hird.


text:
Kevin Garnett explains why the NBA no longer wants veteran players around rookies
Will Starjacki
Kevin Garnett believes NBA teams should hire more veteran players
Former NBA player and a true legend of the game, Kevin Garnett, gave an interesting interview for the New York Times. He touched upon several things from his NBA career and gave an interesting answer when asked about the younger generation of players. Unlike some other older players, Garnett supports the younger players and acknowledges their skillset and ability to play the game. He even said that a lot of the players from his generation wouldn't be able to compete in today's game because it's so much different.
The importance of veteran players
Garnett also talked about an issue other NBA players spoke about before, and it's the lack of true veterans on rosters of NBA teams. There is a notion around the league; teams want younger players on the squad and how veterans are no longer welcome to the extent they were before.
Garnett believes the main reason is that veteran players would often educate young players on the dos and dont's of being a professional NBA player. There are some things that the NBA doesn't train young players about, which in his mind is the role of veterans who educate players on how to act off the court and how to manage their contracts and their money.
"Shaq's probably not going to get thrown out of the game for staring" - When Rasheed Wallace got ejected for staring at a referee
"He'd be right up there with Michael Jordan, Patrick Ewing, Larry Bird, and David Robinson" - Ex-Spurs coach on if George Gervin played in the 90s
He dunked his head in the ice and almost passed out...he's done that a couple times" - Ricky Davis on how Pat Riley motivated the Miam
"What I meant was, when it comes to off-the-court stuff and dealing with family and finances and the lifestyle of the league, you need veterans. Veterans sit around during dinners and plane rides and talk about people who have come before you: players that fought for midlevel exceptions and Bird rights. The franchise is not going to teach the players this. The players are exchanging the information you need to go up against a machine like the league."
Kevin Garnett, via New York Times
Adam Silver is doing a good job
Garnet argues Adam Silver is doing a great job in creating a level of trust between the players and the league, making sure everybody's voice is equally heard.
"Well, Adam Silver has done a great job of bringing the partnership to a nice balance. Adam is my homie. With him, players feel like they have a voice. I don't know how the owners feel about players having such a voice, but everybody has to be happy."
Even though there might be some truth in what Garnett is saying about the lack of veteran leadership on some teams, it's definitely not true that it is universal for the entire league. There are multiple teams in the NBA with several experienced veterans who either have bigger or minor roles on the team but are present nevertheless. Whether that will change in the near future remains to be seen, but quality veteran leadership is necessary for any team hoping to win a championship in the NBA.
Kevin GarnettAdam SilverNBA
Follow WStarjacki
The Portland Trail Blazers couldn't help but fume over the referee's decision to hit Rasheed Wallace with a second technical foul simply because he was staring at him
George Gervin's former coach raved about his game and declared that he would've wound up joining the creme de la creme of the NBA had he played in the 90s
Former Miami Heat guard Ricky Davis talked about the time Pat Riley dunked his head inside an ice bucket and how it was like to be motivated by the Hall of Fame coach
"I've played against Michael Jordan, Magic Johnson...Luka is right in the same breath" - Dallas Mavericks legend Derek Harper on Luka Doncic
Derek Harper is so enamored by Luka Doncic's game that he already puts him right up there alongside Michael Jordan and Magic Johnson
"They don't value me" - Kenny Smith reveals how he cried after witnessing the abysmal culture of the Sacramento Kings
Kenny Smith details just how miserable the culture of the Sacramento Kings was, having spent 3 years with them
He's setting the bar for what an athlete can be, not everyone can do this" - Kevin Durant speaks on LeBron James' legacy and longevity
Brooklyn Nets Kevin Durant recently praised Los Angeles Lakers' LeBron James for his scoring ability, longevity and lasting NBA legacy
"Once we won Game 3 against Dallas, we all knew that we could win it" - Antoine Walker reflects on Miami Heat's first NBA championship
The championship run was a validation of what the 2006 Miami Heat could accomplish.
That time a fan dressed as a referee blew the whistle in a Warriors vs Jazz game
NBA fans have engaged in some crazy antics


Most of us have heard Jesus' beatitudes–but have we ever stopped to ask, "What is a beatitude?" A beatitude is a blessing or an announcement of God's favor. Think about that. The first detailed teaching we have from Jesus in our New Testaments is a pronouncement of God's blessing.
In fact, the Beatitudes are a nine-fold pronouncement by Jesus of God's blessing. Nine times Jesus makes statements and He begins with the word "blessed." In Matthew, Jesus begins his public ministry by telling people about the blessing from God that is ours when we are within God's reign or God's kingdom.
When it comes to our part, notice that the Beatitudes are far more about our being than our doing. The doing is very important but what we do flows out of who we are. That's what these Beatitudes are about: a way of being when we accept the reign of God in our lives.
You see, we can't live in these ways on our own but when we begin to live under God's kingly role then these beatitudes become the direction of our lives. Again, as Oswald Chambers put it, this is the way "we will live when the Holy Spirit is getting His way with us." It is only because of the strength God gives us through His Holy Spirit living in us that we are even able to live in the direction of the Beatitudes.
That's why the Sermon on the Mount is tied so closely to the Kingdom of God. We just can't live like this on our own. It is only with the help of our King and the strength that He provides that we can begin to show the world what a life lived under the reign of God looks like.
That's what the entire Sermon on the Mount is about. We who are following Jesus are aliens in this world. We are exiles here. We march to the beat of a different drummer. We have a different King and as He reigns in our lives every day we give the world a glimpse of what it is going to be like when our King returns in glory and the will of God is done on earth even as it is being done in heaven.
The way of being that Jesus sets before us in the Sermon on the Mount is then a counter-cultural way of life in this world that has not yet come under God's reign. We are salt in this world. We give this world a foretaste of the Kingdom of God that is still to come in its fullness.
Notice again, however, that it all begins with God's blessing. "Blessed, blessed, blessed"; nine times. I think Jesus is trying to tell us something. The blessing comes first. This is such a hard lesson for us to learn. I know it is for me. I began following Jesus as his disciple over 37 years ago and I'm still trying to accept this truth at a heart level.
Most of us are doers. We are solution-oriented and task-oriented. We like to boil everything down to clear steps to take. "OK, we are talking about the blessed life and here are the nine things we need to do to have a life that will be blessed by God." That would be the American way of hearing these Beatitudes, but what a distortion of them it would be.
We do not do x, y and z in order to receive God's blessing in our lives. No, we stop the doing that is really a futile effort to be our own God and, instead, we surrender to the Lord and we accept our new identity under His kingly rule. He begins His reign over us by blessing us richly over and over again every day and, as our King blesses us, He also enables us to begin to live in imitation of Him.


text:
Can i stream the super bowl
May 31, 2020 · With DIRECTV NOW, you'll get FOX in most markets, meaning that you can catch watch the Super Bowl on FOX. If you are a new subscriber, you can try it out for FREE with 7-Day Free Trial Once you subscribe, you will be able to stream the Super Bowl and local NFL games next season on Apple TV, Roku, Amazon, Fire TV, Chromecast, iOS, and Android.
Feb 02, 2020 · If you're hoping to stream the 2020 Super Bowl via your PlayStation 4 or Xbox One, we're here to help. You'll be able to watch the game for free via any of your consoles, provided you're The NFL has made their playoffs available for more people to stream year after year. Still it only matters if you can watch the biggest game on the devices you love. Here's how to make sure you can watch Super Bowl LIV on Playstation. Super Bowl LIV will kick off at 6:30 p.m. on Sunday, Feb. 2, 2020 from Hard Rock Stadium in Miami Gardens, Fla. CBS Sports provides the latest picks, news and analysis for Super Bowl LIV. The Super Bowl will be played on Sunday, Feb 2, 2020 at Hard Rock Stadium in Miami, Florida Feb 02, 2020 · How to watch the 2020 Super Bowl: Channel, live stream, start time, odds. Updated on: February 2, 2020 / 6:00 PM / CBS News Chiefs & 49ers prepare for Super Bowl 54 . Feb 02, 2020 · Super Bowl 2020 starts at 6:30PM ET on February 2nd. Here's how you can watch the NFL championship on your phone, laptop, Apple TV, Roku, Chromecast, Xbox One, Fire TV, and more.
Jan 28, 2020 · The Apple TV 5th Gen, plus 4K models of Roku and Fire TV devices, can also use the Fox Sports app to stream Super Bowl LIV. These devices will get the broadcast in 4K, which should make this one
Feb 01, 2019 · With Super Bowl LIII almost here, you're probably making plans to watch the Patriots-Rams game on CBS. You're all set if you have a pay-TV service, use an antenna, or are attending a Super Bowl party. Jan 30, 2020 · How to watch Super Bowl LIV for free Fox Sports is live-streaming the game, beginning at 6:30 p.m. ET, for free across a wide variety of platforms including streaming devices, computers, tablets Relive the Super Bow LIV matchup between the San Francisco 49ers and the Kansas City Chiefs by watching this full game replay brought to you by NFL Game Pass. Relive the Super Bow LIV matchup between the San Francisco 49ers and the Kansas City Chiefs by watching this full game replay brought to you
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National Real Estate News
As Trade War Escalates, Fed Chair Powell Struggles To Maintain Stability
National Economy View count:
National Economy
August 25, 2019 Matthew Rothstein, Bisnow East Coast
Wikimedia/The White House
President Donald Trump and Federal Reserve Chairman Jerome Powell at Powell's nomination to lead the U.S. Federal Reserve in November 2017.
U.S. Federal Reserve Chairman Jerome Powell believes his job to be ensuring stable growth for the national economy, and President Donald Trump is making that job exceedingly difficult.
In response to Trump's application of a 10% tariff on $300B worth of previously unaffected imports to the U.S., the Chinese government announced a 10% tariff of its own on $75B worth of American exports to China on Friday, The Wall Street Journal reports. Meanwhile, Powell was speaking at the Kansas City Fed's annual summit in Jackson Hole, Wyoming, carefully discussing the challenges such back-and-forth exchanges present for the Fed.
"While monetary policy is a powerful tool that works to support consumer spending, business investment and public confidence, it cannot provide a settled rulebook for international trade," Powell said in prepared remarks.
The Fed reduced interest rates for the first time since the Great Recession in July, and Powell hinted that it may do so again at its next meeting in September, the WSJ reports. Though he claimed that the U.S. economy is still healthy with respect to inflation and job numbers, he cautioned that there is "no recent precedent" for monetary policy in the midst of a trade war.
"Financial markets have reacted strongly to this complex, turbulent picture," Powell said, referring to slumping international stock markets according to the WSJ.
Later on Friday, Trump added more complexity and turbulence by announcing on Twitter that in retaliation for China's new tariffs, he would increase all existing and forthcoming tariffs by 5%. He also called Powell an "enemy" on par with Chinese leader Chairman Xi Jinping, due to Powell's insistence on remaining independent from the White House, as part of a stream of tweets about the trade war.
As usual, the Fed did NOTHING! It is incredible that they can "speak" without knowing or asking what I am doing, which will be announced shortly. We have a very strong dollar and a very weak Fed. I will work "brilliantly" with both, and the U.S. will do great...
....My only question is, who is our bigger enemy, Jay Powell or Chairman Xi?
Minutes later, Trump "ordered" U.S.-based companies to cease business operations in China and find alternatives domestically or in other countries, though his authority to dictate such decisions for private companies is extremely limited, the WSJ reports.
The increased pace of retaliations from both sides has added even more uncertainty for the global economy, as analysts now expect the trade war to last longer than any benefits a second interest rate cut from the Fed would provide, Bloomberg reports.
Contact Matthew Rothstein at matt.rothstein@bisnow.com
Related Topics: Federal Reserve, Interest Rates, China, Jerome Powell, yield curve, The Federal Reserve, Xi Jinping, tariffs, trade war, U.S. Federal Reserve, President Donald Trump, inverted yield curve
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We've made it past episode 1!
Today, David and Seth address a topic that needs to be discussed before diving deeper into the podcasts. Why do you need marketing? What exactly is marketing?
I guess we should start out with how we each define marketing is and why it matters to your business. We're going to do our best to keep it to 30 minutes, because both of us could talk about this topic forever!
Who needs it…small businesses and large businesses?
What else do they want/need?
Are you still interested in continuing to engage with them?
Is marketing and sales the same thing?
Why is digital marketing so hard to understand?
How does digital marketing help the bottom line?
Why is social media marketing so hard to prove ROI.
Hello! Welcome to the inaugural episode of the Tasty Fish Marketing Podcast. A podcast about all things marketing from people who live it. I'm Seth Goldstein of Goldstein Media, with me is my co-host David Birnbaum of Birnbaum Consulting.
How we got into marketing.
What we want to do with the podcast.
Our goals for you, our audience.
What it's like running independent firms vs. working for larger firms. We've done both.
Some topics and ideas we want to discuss on the show.
What to expect from the podcast and Seth and David.
That's our show. The first episode is in the bag. You can find David online at BirnbaumConsulting.com and you can find Seth online at GoldsteinMedia.com.
We want to hear from you. Email us at podcast@tastyfishmarketing.com! Also be sure to subscribe as well, go to TastyFishMarketing.com.
Marketing Forward Podcast Episode 6 – It's Finally Spring!
Marketing Forward Podcast – Episode 1 – New Name and Cross Branding OR How Networking and Marketing Go Together.


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Ag branded UK's deadliest industry as deaths make up more than 20% of workplace stats
News04 Jul 2019 Lauren Dean
The sector has a rate of injury some 18 times higher than the average across all industries.
Lauren Dean
Lauren kicked off her print journalism career with Farmers Guardian shortly after graduating from the University of Leeds with a degree in B ...Load More
credit: NFU
More than one in five workplace fatalities occurred on farms last year as agriculture was branded the deadliest industry in the UK.
The Health and Safety Executive (HSE) outed the figures on Wednesday (July 3), showing that 32 people out of the total 147 workers killed between April 2018 and March 2019 were involved in the industry.
The figure was up from the annual average of 29 between 2014/15 and 2018/19 – with the rate of fatal injury per 100,000 workers also up from 8.29 to 9.21.
Agriculture looking to UK forestry industry in attempt to turn around safety record
HSE 'purposefully talks about agriculture killing people' to encourage attitude shift
Safety warning as two die and two injured in wall collapse on UK farm
Stopping killing people has to be our priority, NFU Council told
Sixty four per cent of those killed in agriculture were self-employed.
HSE chairman Martin Temple said: "These statistics remind us that, in certain sectors of the economy, workplace deaths remain worryingly high.
"Agriculture, forestry and fishing accounts for a small fraction of the workforce of Great Britain, yet accounted for over 20 per cent of worker fatalities in the last year.
"This is unacceptable and more much be done to prevent such fatalities taking place."
farm lifeFarm safety
Previous Article Fury at plea to afforest half of the UK's uplands to help tackle climate change
Next Article How British farmers can win £40,000 to transform their agri-tech business


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These Are the Best Self-Tanners We've Ever Tried
Sophie Wirt and Karina Hoshikawa
The Best New K-Beauty Skin-Care and Makeup Launches Coming in July
Marci Robin and Kaleigh Fasanella
How Shine Louise Houston Is Changing the Way We Think of Porn
Cameron Glover
The Best New Self-Tanners Come From...Ireland?
Catherine Quinn O'Neill
Ireland is known for a lot of things—St. Patrick's Day, Guinness, Colin Farrell—and now you can add really, really, really amazing self-tanners to that list. Yes, you heard that right. Fair-skinned Irish women take their faux bronze so seriously that they buy more self-tanning products per capita than any other country in Europe. And they're obsessed with getting the formula exactly right. Recently, they've been shipping those Irish innovations to the U.S. to share the love with our fair-skinned girls. Here, two of my favorite new formulas:
Karora Express Bronzing Mousse. In Ireland, there's a slang term for a woman who's gone a little overboard in the tanning department. "'Tango,' short for tangerine," says Karen Brown, founder of Karora. You won't earn that title with this self-tanner, which uses a special delivery system to drive the DHA into your skin faster. The effect is a nice, bridal glow in an hour, and a deep, sexy bronze in two. Just one caveat: It smells a little like Skittles.
Vita Liberata Phenomenal 2-3 Week Tan Mousse. My friends and I are obsessed with this lightweight mousse, which has time-released DHA to keep your tan looking perfect (and streak-free) for up to three whole weeks. Bonus: It doesn't smell. At all.
Find out more about self-tanners, and enter to win some for free, by picking up our August issue, on newsstands now.
• The 10 Commandments of Self-Tanning
• 10 Under $20: Self-Tanners
• The Top Idiot-Proof Self Tanners
Alex Morgan Wore Bright Blue Nail Polish at the World Cup
Why Glitter Eyebrows Are Trending for Fall


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Tailgating Party Ideas To Celebrate Your Favorite Team #FeelTheOrgullo
This is part of a sponsored collaboration with the NFL and DiMe Media. However, all opinions expressed are my own.
As a New Yorker born and raised in Queens, I've always been loyal to the New York Jets. I stick by my beloved football team through thick and thin, and wear their colors of green and white with orgullo. Latino players, fans, and coaches have a strong sense of pride not only in their culture but also in their team and in the NFL.
This year, during Hispanic Heritage Month, the NFL and all 32 teams will honor the rich history, heritage and tradition of Latinos and their positive impact on the game and country through a series of special events such as designated home games with in-stadium themed elements and local community outreach. I'm joining in by sharing our Latino-inspired tailgate party ideas that I love to offer friends at our gameday parties!
We like to set out a mini-buffet with mini-tapas and create-your-own foods, like taquitos and a "Make Your Own Nachos" bar, to let our guests have fun making their own gameday snacks. And of course, everything is decorated in green and white for my team!
Tailgating Queso Recipe
2 bell peppers, seeded and diced
1 shallot, diced
1 jalapeño, seeded and diced
1 tsp adobo
16 ounces sharp cheddar cheese, chopped into 1/2 inch cubes
1. In a pot over medium heat, add butter, pepper, shallot, jalapeño, and adobo. Stir together until butter has melted and starts to simmer, then turn heat to low.
2. Add in cheddar cubes slowly, a few at a time, stirring while it melts. Keep stirring until all cheddar cheese has been added and melted together. Turn off heat and serve or keep warm until ready to serve.
Toppings/ Sides for Make Your Own Nachos Bar:
Ground beef, seasoned
Chopped bell peppers
Lime wedges and cilantro
Chicken and beef taquitos
Throughout Hispanic Heritage Month, fans can visit www.NFL.com/HispanicHeritage for a look at the personal stories of Hispanic players, past and present, who have left a lasting legacy on the NFL. They are also on twitter, sharing the latest updates from around the league, 24/7 and in Spanish. Follow them @NFLEspanol, and learn about American football's rules and power players at www.AprendeNFL.com.
Join the #FeelTheOrgullo Photo Challenge!
Share your pics on twitter @NFLEspanol and instagram @NFL with #FeelTheOrgullo for a chance to win some great prizes, like the Grand Prize Pack of a Wilson NFL Shield Authentic Game Ball, valued at $100 and Microsoft Surface 3 – 64GB / Wi-Fi, valued at $499, or the Runner-Up Prize Pack of a Super Bowl 50 Ceremonial Flag with Fringe, valued at $150, and and NFLshop.com gift certificate worth $150!
Feel The Orgullo!
Soup as Good as Homemade @Campbells
Heading Back To The Future! Celebrating 30 Years and Partying Like It's 1985! (Free Printables)
We tailgate a lot and it's definitely all about the snacks! A queso bar is an AWESOME idea.
I love this setup! It all looks delicious.
Tailgating is so much fun. I have not done it in years though. I used to do it with co-workers from my old job.
This looks so great. I'll definitely be going with this setup the next time we have a party. I love to make our football parties fun like this.
Betsy Segars
Queso is my favorite! I love the toppings bar that you made! So smart.
I am not much into sports, but with a spread like that, I could watch the game 😉 I bet my Latino friends would sure love the party food!
I love nachos. What a great idea for game day – instead of hot dogs or burgers!
Love the setup! I need to do something like this for our next football get together.
Born and raised New Yorker and somehow sports have never really been my thing, but I do enjoy attending watch parties with friends, I may not be about the sports, but I am about the FOOD!


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