text:
INBA Statement on Charlottesville Protests
, Chamber News, Member News
Media Contact: Marvo Reguindin, General Manager
509-455-3699, marvo@inbachamber.org
The recent events in Charlottesville, Virginia shocked, saddened, angered, and disappointed many of us. Indeed, feelings across the spectrum were felt—and will continue to be—throughout the United States. Here, in the Inland Northwest, INBA reaffirms its commitment to advocate for the fairness, inclusivity, and equity for all individuals in the communities we serve. We believe that when businesses support and embrace diversity, the economy grows and our community thrives.
To achieve this, the right to assemble peacefully and freedom of speech must be upheld. While this applies to any and all citizens—and should continue to do so—we believe that there is a clear and distinct difference between expressing beliefs, values, and grievances, versus a call to harm fellow human beings. This disregard for human life is at the core of what several of the groups–namely the KKK, neo-Nazis, white supremacists, and white nationalists—who participated in the protests, is at the core of their invocation. It is a malicious and hateful call to action that is unacceptable as a society, harmful for humanity, and detrimental to businesses and our economy.
Regardless of race, color, religion, gender, sexual orientation, gender identity or expression, national origin, age, genetic information, disability, or veteran status, our community is stronger together. As the region's LGBT and ally chamber of commerce, INBA will continue to advocate on behalf of these individuals to create an economically robust and civically engaged community through the acceptance of diversity throughout our region.
Inland Northwest Business Alliance (INBA) is Spokane's LGBTA Chamber of Commerce with members in Eastern Washington and North Idaho. INBA was established in 1994 with a charter group of 25 members as a 501(c)6 non-profit organization to network and socialize in a safe environment. INBA's mission is to develop a prosperous business community by advocating LGBT and Ally business perspectives.
Click here to download a PDF of this Press Release


Nature Spirits are metaphysical beings who inhabit and work with the energies of the earth in the ongoing work of Creation and evolution. They are involved in every aspect of life and in every natural process. Every part of the world is alive and nature spirits are to be found everywhere in nature.


Video transcript available at https://www.youtube.com/watch?v=LkbntRI3ihw.
Many electrical and electronics installers and repairers work in repair shops or in factories. Installers and repairers may have to lift heavy equipment and work in awkward positions. The majority worked full time in 2016.
Electrical and electronics installers and repairers need at least a high school education, but most specializations require further preparation through advanced education, apprenticeship training, or work experience.
The median annual wage for electrical and electronics installers and repairers was $57,890 in May 2018.
Overall employment of electrical and electronics installers and repairers is projected to show little or no change from 2016 to 2026. However, growth rates will vary by specialty. Job opportunities should be best for qualified workers with an associate's degree in electronics.
Explore resources for employment and wages by state and area for electrical and electronics installers and repairers.
Compare the job duties, education, job growth, and pay of electrical and electronics installers and repairers with similar occupations.
Learn more about electrical and electronics installers and repairers by visiting additional resources, including O*NET, a source on key characteristics of workers and occupations.
Electrical and electronics installers and repairers use diagnostic equipment to troubleshoot electric motors.
Electrical and electronics installers and repairers usually work in a clean shop.
Many technical colleges have basic electronics programs that include practical experience labs.
The median annual wage for electrical and electronics installers and repairers was $57,890 in May 2018. The median wage is the wage at which half the workers in an occupation earned more than that amount and half earned less. The lowest 10 percent earned less than $32,640, and the highest 10 percent earned more than $91,840.
Employment of motor vehicle electronic equipment installers and repairers, which represents less than 10 percent of this profile's 2016 employment, is projected to decline 26 percent from 2016 to 2026. Motor vehicle manufacturers continue to install more and higher quality sound, security, entertainment, and navigation systems in new vehicles. These new electronic systems require less maintenance and will limit installation of aftermarket products.
This table shows a list of occupations with job duties that are similar to those of electrical and electronics installers and repairers.
on the Internet at https://www.bls.gov/ooh/installation-maintenance-and-repair/electrical-and-electronics-installers-and-repairers.htm (visited April 21, 2019).


text:
import sys
import os
from bgenlocations import TOOLBOXDIR, BGENDIR
sys.path.append(BGENDIR)
from scantools import Scanner

LONG = "Appearance"
SHORT = "app"
OBJECT = "ThemeDrawingState"

def main():
    input = LONG + ".h"
    output = SHORT + "gen.py"
    defsoutput = TOOLBOXDIR + LONG + ".py"
    scanner = MyScanner(input, output, defsoutput)
    scanner.scan()
    scanner.close()
    print "=== Testing definitions output code ==="
    execfile(defsoutput, {}, {})
    print "=== Done scanning and generating, now importing the generated code... ==="
    exec "import " + SHORT + "support"
    print "=== Done.  It's up to you to compile it now! ==="

class MyScanner(Scanner):

    def destination(self, type, name, arglist):
        classname = "Function"
        listname = "functions"
        if arglist:
            t, n, m = arglist[0]
            # This is non-functional today
            if t == OBJECT and m == "InMode":
                classname = "Method"
                listname = "methods"
        return classname, listname

    def writeinitialdefs(self):
        self.defsfile.write("def FOUR_CHAR_CODE(x): return x\n")

    def makeblacklistnames(self):
        return [
                "GetThemeFont",         # Funny stringbuffer in/out parameter, I think...
                # Constants with funny definitions
                "appearanceBadBrushIndexErr",
                "appearanceProcessRegisteredErr",
                "appearanceProcessNotRegisteredErr",
                "appearanceBadTextColorIndexErr",
                "appearanceThemeHasNoAccents",
                "appearanceBadCursorIndexErr",
                ]

    def makeblacklisttypes(self):
        return [
                "MenuTitleDrawingUPP",
                "MenuItemDrawingUPP",
                "ThemeIteratorUPP",
                "ThemeTabTitleDrawUPP",
#                       "ThemeEraseUPP",
#                       "ThemeButtonDrawUPP",
                "WindowTitleDrawingUPP",
                "ProcessSerialNumber_ptr",              # Too much work for now.
                "ThemeTrackDrawInfo_ptr",       # Too much work
#                       "ThemeButtonDrawInfo_ptr",      # ditto
                "ThemeWindowMetrics_ptr",       # ditto
#                       "ThemeDrawingState",    # This is an opaque pointer, so it should be simple. Later.
                "Collection",           # No interface to collection mgr yet.
                "BytePtr",              # Not yet.
                ]

    def makerepairinstructions(self):
        return [
                ([("void", 'inContext', "OutMode")],
                 [("NULL", 'inContext', "InMode")]),
                ([("Point", 'ioBounds', "OutMode")],
                 [("Point", 'ioBounds', "InOutMode")]),
                ]

if __name__ == "__main__":
    main()

redpajama_set_name: RedPajamaGithub


If you are looking to score a great deal on a beach resort in Costa del Sol, we've got you covered. If you want deals for hotels on the beach in Costa del Sol, guess what? We've got you covered. We don't want to sound too redundant but your chances of finding a great deal on the hotel you want in Costa del Sol are pretty good when planning with us. Check out some of our top deals below.
"Excellent view of the beach. Room had sliding glass door that went onto a balcony. Sitting out there you hear the roar of the ocean. Very pleasing."
"Large room well furnished overlooking the pool. Lovely grounds. 5 mins to beach ,30 mins walk to marina. Decent breakfast. Surprisingly good."
"Friendly staff and good location. Excellent restaurant on the beach. Recommend the paella."
"Nice hotel in Marbella located at the beach, next to Nikki Beach which was closed. Was my second stay within 4 weeks with positive experiences. "
" Excellent staff .Thank you MarioExcellent location"
"Great stay. Hotel is larger than expected (a plus) and is a 2 minute walk to the main bus & train station (along with a mall with a variety of eateries). Staff was polite and efficient, room was large and leaving nothing."
"Not a bad hotel, close to Puerto Banus and Restaurants "
"Es un hotel centrico casi todo esta a una distancia de 10 a 15 minutos caminando ."
"Check in staff were very nice. Ate at the a la carte restaurant and both meals we had were good. No complaints. Room service was quick and food there was good. Overall good experience, would definitely stay here again. "
"This is a nice hotel but a little bit of a walk to the shops and restaurants. The staff was great, friendly and helpful. On-site parking and a great breakfast buffet for the money. If you are a light sleeper, this may not be the hotel for you. I stayed on the 11th floor and could hear people talking from the other end of the hallway because there is no carpet in the hallways to absorb sound."
"Nice hotel. Nice view of the sea. Good food. It is not the Ritz but perfect for a mid-winter vacation. "
"This resort was gorgeous and in a great location. Everything is at your fingertips and great places to eat within walking distance. This place is a hidden treasure! We took my Husband on a surprise trip for a special birthday and he was so impressed by the accommodations. If you don't visit here, you missed out on a great place!! "
"We found this hotel easy to find, and a short 10-15 minute walk from the train station. Everything we wanted to visit was also just a short walk from this hotel. The staff was extremely friendly and very helpful. The room we stayed in was more spacious than we were expecting, and was comfortable enough to enjoy staying in or to return to after a long day of touring. A restaurant was available, but we did not use it. Breakfast, however, was nice with plenty of different foods to choose from."
"This is a beautiful property located right on the Mediterranean Sea. I have stayed at very nice hotels and this one is great. The staff is very accommodating and will tend to your every need. They are very detailed oriented and will make sure you are getting the most out of your visit to Spain. For example, we took a quick holiday to Sevilla and the staff arranged a brief stay there for us. They went out of their way to make sure we had Flemenco reservations at a nice venue and nice accommodations. When we return to the Costa del Sol we will definitely stay here again. I can't say enough amazing things about this hotel!!"
"Haven't stayed in a Hilton for years since we only stay at Marriotts. Asked for wake up call and we no one called.Heard that less than honest taxi drivers are one of Spain's biggest threats even over potential terrorists. Hilton called us for cab and employees said it should only cost between 8-10 euros for five minute ride to airport. Meter said 7.8 and driver charged us $19 saying this was minimum charge We expected Hilton to screen their cab drivers because Marriott does and we never had a problem like this with them. This left us a bad taste for Hilton and Spain. Can you get a a 10 euro refund. It's the principle of the thing!"
"Perfect location and helpful staff. Only complaint was the heating/cooling. My room was quite warm. I was told each floor had a central control and my floor had the heat on - thus my room could have the system off or on(heat). One afternoon the staff did turn the a/c on for me for an hour to cool my room down a bit. Window opened which was helpful. Overall I enjoyed my stay and felt it was a nice, quiet hotel with good breakfast buffet."
"Encantada con este hotel, super bien ubicado al lado del metro"
Well, now you can forget all of that, thanks to Travelocity. At Travelocity, you can view tons of the best deals for Costa del Sol beach vacation hotels, flights, rental cars, and more!
This page provides you with all you need to plan your trip to Costa del Sol. Browse through flight deals to secure the dates of your adventure. Then choose from the best Costa del Sol beach hotels such as Sol House Aloha - Costa del Sol and Hotel Fuerte Marbella. Take advantage of our interactive map to fill up your list of places to go and things to do. With 139 attractions to see, you'll be plenty busy during your stay. You may have time to see all of the beaches in Costa del Sol, Malaga.
We also offer car rental deals so you can actually do everything you want to do without relying on public transportation. And if all of this planning sounds daunting, we offer some great packages combining Costa del Sol beach hotel deals with flight and rental car deals.
Normally, trying to find all of the great points of interest in one area can be a real pain. Luckily, we have a handy map to make that process much easier! Our interactive map shows beach hotels in Costa del Sol along with nearby places to see such as Venus Beach, La Carihuela, and Nerja Beach.
When you are on vacation, time spent traveling to other places is time wasted. There are 139 places to see such as Fuengirola Beach and Estepona Beach. You'll want to be staying at one of the nearest Costa del Sol beachfront hotels. Find hotels close to all of the sights so that you spend less time getting there.
Enjoy the sunshine with the locals in this historic Old Town plaza filled with majestic monuments, Picasso tributes, lanterns, trees and restaurant terraces.
Our package deals include everything you need to get your trip to Costa del Sol, Malaga started. We offer a variety of packages that include hotels near a Costa del Sol beach alongside great prices on flights and car rentals. With the major planning out of the way you can start deciding which pair of flip flops is coming with you to Costa del Sol.
Having to rely on public transportation can be a painstaking process in an unfamiliar area. If you are staying in one of the best Costa del Sol beach hotels, there is a good chance you have a ton of places to explore around you. You can even check out other major cities nearby. Let the deals below show you how much you can save on a rental car.
If the hotels on the beach in Costa del Sol weren't quite a bullseye, there are plenty of other beach resorts nearby to check out.
We don't want you to miss out on popular beach destinations around the world, compare the Costa del Sol beach hotel deals you see above with some of these worldwide beach getaways.


1Lecturer, Pal College of Nursing and Medical Sciences, Haldwani, Uttarakhand.
2Lecturer, College of Nursing, All India Institute of Medical Sciences, New Delhi.
3Professor, Chief Fetal Medicine, Department of OBG, AIIMS, New Delhi.
4Additional Professor, Department of Hematology, AIIMS, New Delhi.
Background: Umbilical cord blood banking (UCBB) was alien concept in India until a few years back and now it is gaining popularity. Method: A cross sectional survey was conducted to assess the knowledge and attitude of 56 nurses enrolled from the labour room and maternity ward of the facility. Pre-validated and tested self-developed knowledge questionnaire and attitude scale were used to collect data regarding stem cells and UCBB. Results: Most of the nurses had good knowledge (42.86%) and neutral attitude (78.6%) with a mean knowledge and attitude score of 16.84 ± 4.59 and 53.75 ± 8.26 respectively. None of the nurses received any pre-service or in-service education regarding stem cells and UCBB, however 17 nurses assisted/witnessed UCBB and all these nurses were from labour room. All of the nurses expressed that they wanted to have more information regarding stem cells and UCBB. Majority (62.5%) of the nurses had heard about UCBB and reported other health care workers (74.28%) as their knowledge source. There was a positive correlation between knowledge and attitude scores of nurses (r=0.532, p<0.01). Nurses who witnessed/assisted UCBB had significantly higher knowledge (p=0.01) and attitude (p=0.009) scores than that of nurses who did not witnessed/assisted. Participants who heard about UCBB earlier had significantly better knowledge (p=0.0008) than those who did not heard about UCBB. Attitude scores of the nurses was significantly associated with their professional educational status ((p=0.026). Conclusion: Nurses had good knowledge and neutral attitude regarding stem cells and UCBB. They wanted to have more information.
Ambili Venugopal, Poonam Joshi, Dipika Deka, Tulika Seth. Knowledge and attitude of nurses regarding stem cells and umbilical cord blood banking in a selected tertiary care facility. Asian J. Nur. Edu. and Research. 2016; 6(2): 240-244.


text:
Home /// Resources /// A Closer Look at Still Alice
A Closer Look at Still Alice
How do you stay present? How do you keep the life going that you value?
Those are the words of actress Julianne Moore, who recently won an Oscar for her portrayal of a woman struck with early-onset Alzheimer's in the movie Still Alice. A 50 year-old linguistics professor with keen intellect, Alice Howland's character begins the film troubled by moments of forgetfulness that quickly progress into terrifying episodes of disorientation – symptoms that land her in the neurology department of Columbia Presbyterian Hospital, where she's given her shocking and devastating diagnosis. What follows is the poignant, and sometimes devastating struggle that Alice and her family share as they try desperately to cope with their new reality.
While this may sound like just a good Hollywood script, Still Alice depicts a struggle that thousands of American families are facing right now. Over 200,000 of the 5.3 million people in the US with Alzheimer's are under the age of 65 and considered early-onset –- some in their 30s and 40s. And, like Alice Howland, almost 2/3 of all Alzheimer's patients are women. Most of those diagnosed before age 65 have the common form of Alzheimer's with similar symptoms and progression; a few hundred have what's known as Genetic Alzheimer's disease, which is extremely rare and carries a genetic mutation passed through successive generations.
Because early-onset Alzheimer's strikes so young, its proper diagnosis can be tricky and elusive. Many of those exhibiting early symptoms – forgetfulness, losing track of time or familiar objects, changes in mood or personality – are often misdiagnosed as suffering from stress, or even neurological disorders like multiple sclerosis. If you or someone you know has reason to believe they may have early-onset Alzheimer's, it's important to see a specialist in the field who can perform the proper evaluation complete with brain imaging, a physical and neurological exam, mental status testing, and a full medical history.
The Alzheimer's Association website provides meaningful support for patients and families impacted by early-onset Alzheimer's. Click here for their full resource guide.

redpajama_set_name: RedPajamaCommonCrawl


Calculator for resistor in base of transistor by Marjan Shtrkoski.
Calculate the current you need to pass through the transistor when its on, that is your collector current.
The current gain, beta, Hfe, is a value you can find in the datasheet for the specific transistor.
Supply voltage is the voltage that you use to drive the base of the transistor with.


Physicians continue to struggle with the clinical management of pain, in part because of the large interindividual variability in the efficacy, occurrence of side effects and undesired severe adverse drug reactions from the prescribed analgesics. Pharmacogenomics, the study of how an individual's genetic inheritance affects the body's response to medications, has an important role and can explain some of this interindividual variability. Genetic identification of known variant alleles that affect the pharmacokinetics or pharmacodynamics of medications used for pain management can enable physicians to select the appropriate analgesic drug and dosing regimen for an individual patient, instead of empirical selection and dosing escalation. In this article, clinically relevant pharmacogenomic targets for the management of opioid pain, including efflux transporters, proteins that metabolize drugs, enzymes that regulate the neurotransmitters that modulate pain, and opioid receptors, will be reviewed.
The control of pain, a complex and subjective experience, is critical to clinical success in caring for patients. Opioids such as oxycodone, methadone and morphine are the recommended therapy by the World Health Organization and the European Association for Palliative Care for moderate to severe pain [1, 2]. However, the use of opioids in pain management requires careful dose escalation and empirical adjustments based on clinical response and the presence of side effects or adverse drug reactions (ADRs). Unfortunately, successful pain management treatment - defined as adequate analgesia without excessive adverse effects  - can be challenging . Unpleasant opioid side effects, such as nausea, vomiting, constipation and sedation, are common and can lead to absence from work, poor performance at work and the resulting risk of job loss, and a diminished quality of life. The most serious issues involve the risk of sedation, depression of respiration and unintentional death due to inability or poor ability to metabolize the medications successfully. An individual's genetic makeup may predispose the patient to these adverse effects and reduced efficacy. Pharmacogenomic approaches offer insight into the genetic variables that can affect a drug's uptake, transport, activation of its target, metabolism, interaction with other medications and excretion. The use of pharmacogenomics in patients requiring pain management can lead to more efficient opioid selection, dose optimization and minimization of ADRs to improve patient outcome.
Cellular transporters control the uptake, distribution and elimination of drugs. P-glycoprotein is an efflux transporter also called adenosine triphosphate-binding cassette, subfamily B, member 1 (ABCB1) or multidrug resistance 1 (MDRD1) . It is expressed in hepatic, intestinal and renal epithelial cells and also on the luminal side of endothelial cells in the blood-brain barrier, and it is a major determinant of the pharmacokinetics and pharmacodynamics of several opioids (such as morphine, methadone and fentanyl) commonly used to treat pain . Genetic variants (such as 3435C > T) in P-glycoprotein have been associated with variability of pain relief in cancer patients treated with morphine . The analgesic effects of morphine are mediated by its interaction at the μ-opioid receptor located in the central nervous system (CNS). P-glycoprotein can limit the concentration of pain management drugs, such as morphine, in the brain because it actively pumps drugs out of the CNS. As a result, homozygous carriers of the 3435C > T variant (TT carriers) experience greater pain relief than heterozygous (CT) or homozygous wild-type (CC) carriers, presumably because higher concentrations of morphine can be achieved in the CNS . Table 1 lists the clinically relevant pharmacogenomic targets for pain management.
The cytochrome P450 (CYP) system is responsible for metabolizing a wide range of therapeutic agents used for pain relief. CYP2D6 is especially important for the activation or inactivation of several opioids used to treat pain, including codeine, oxycodone and tramadol . Typically, the genetic variability of CYP can be grouped into four phenotypes: ultrarapid metabolizers (UM), extensive metabolizers (EM), intermediate metabolizers (IM) and poor metabolizers (PM). UM-classified patients typically contain multiple copies of a gene, which results in an increase in drug metabolism . EM-classified patients are characteristic of the normal population and have a single wild-type copy of the gene, whereas IM-classified patients show decreased enzymatic activity and PM-classified patients have no detectable enzymatic activity . Codeine is a prodrug that requires demethylation to its active metabolite morphine by CYP2D6 before it can exert an analgesic effect. As a result, CYP2D6 PM-classified patients experience ineffective analgesia and increased side effects from the parent drug (codeine) . On the other hand, CYP2D6 UM-classified patients prescribed codeine for pain management generate extensive concentrations of morphine, which can lead to ADRs .
Tramadol, another opioid commonly used for pain management, produces analgesia by the synergistic action of its two enantiomers and their metabolites . Tramadol undergoes metabolism by CYP2D6 to an active metabolite (O-desmethyl tramadol), which has greater affinity for the μ-opioid receptor than does the parent compound . Genetic variations in CYP2D6 have been shown to account for some of the variable pain response in the post-operative period because the CYP2D6 activity has a clinically relevant impact on the level of analgesia mediated by the μ-opioid receptor .
Another important genetic target is uridine diphosphate-glucuronosyltransferase 2B7 (UGT2B7), which metabolizes morphine to morphine 3-glucuronide (M3G) and morphine 6-glucuronide (M6G). The latter has a higher analgesic potency than the parent compound . Morphine is commonly used to control moderate and severe pain associated with sickle cell disease. Darbari et al.  showed that the presence of the UGT2B7 -840G > A genotypes (GG and GA) were associated with lower M3G:morphine and M6G:morphine ratios than AA genotypes. As a result, genetic polymorphisms in UGT2B7 have been shown to decrease the hepatic clearance of morphine, which translates into lower dosage requirements of morphine . In another study , the UGT2B7*2 polymorphism (802C > T) was also shown to be associated with the frequency of morphine-induced ADRs (nausea) in cancer patients. The authors showed that the frequency of nausea was higher in patients without the UGT2B7*2 allele .
Furthermore, the efficacy of opioid analgesia can be enhanced by the co-administration of catecholamines, which are involved in the modulation of pain . Catechol-O-methyltransferase (COMT) is responsible for the inactivation of catecholamines (dopamine, adrenaline and norepinephrine). As a result, genetic variability in the COMT gene can contribute to differences in pain sensitivity and response to analgesics. It has been shown that a common variant allele (1947G > A; Rs4680) results in a three- to fourfold reduction in COMT enzyme activity . Homozygous wild-type (GG) cancer patients required higher doses of morphine to control pain than heterozygous or homozygous variant (AA) alleles [16, 17].
Finally, the μ-opioid receptor encoded by the opioid-receptor-like 1 (OPRM1) gene is the primary site of action for most of the commonly used opioids. The 118A > G polymorphism in this gene results in less effective opioid analgesia, as reported with cancer patients with homozygous variant alleles (GG) who required higher morphine doses for pain relief than homozygous wild-type (AA) participants . In another study , Chou et al. investigated the correlation between the 118A > G polymorphism and patient-controlled morphine consumption in patients undergoing total knee arthroplasty. Patients who were homozygous variants (GG) consumed approximately 60% more morphine than patients who were heterozygous or homozygous wild-type (AA) during the first 48-hour post-operative period. Patient demographics, reported pain and other factors did not differ between the genotype groups. In a similar study , women who had homozygous variants for the 118A > G polymorphism required 30% more morphine to achieve adequate pain control than those who were wild type (AA) during the first 24 hours after a total abdominal hysterectomy. Finally, a significant relationship between the degree of pain relief and the 118A > G genotypes was shown in cancer patients being treated with morphine over the first 2 months of therapy . In the first 7 days of morphine treatment, patients homozygous for the wild-type allele (AA) had more pronounced decrease in pain from baseline than those who were homozygous variants (GG), whose response was almost undetectable .
Genomic variations clearly influence pain sensitivity, the likelihood of developing chronic pain and the response to pharmacotherapy for the management of pain [21, 22]. Pharmacogenomic polymorphisms are definitely important in the interindividual variability in the analgesic effects and occurrence of ADRs of commonly used medications prescribed for pain management, but genetic factors will provide only a partial answer to the interindividual variability observed. Other factors, including biological variations (ethnicity, age and gender), environmental factors (smoking status), co-morbidity and co-medications (potential for drug-drug interactions) must be considered along with the genetic variations because together they all affect the pharmacokinetics and pharmacodynamics of medications used for pain management. Additional studies are also needed to characterize the combined effects of multiple genes along with demographic and clinical variables in selecting the appropriate opioid and predicting the appropriate opioid dose in patients with pain. Large, randomized prospective studies are needed to develop appropriate dosing or treatment algorithms to facilitate the use of genotyping information appropriately by physicians. Furthermore, the continued development of regulator-approved genotyping assays to identify these variant alleles will allow greater access to this information to aid in day-to-day clinical decisions for acute and chronic pain management. The benefits of patient care and safety will result in the incorporation of this knowledge into the standard of care for anesthesiologists and pain management physicians. In the near future, pharmacogenomic approaches in pain management could lead to individualized therapy to best select the appropriate analgesic from the onset to provide sustained efficacy with the lowest side effect profile.
PJJ is an Associate Professor in the Pathology Department at the Medical College of Wisconsin. He is the Director of Clinical Chemistry/Toxicology for Froedtert Hospital/Dynacare Laboratories. NCB is the Director of Midwest Comprehensive Pain Care. She is active in pain medicine and teaches on the subject.
PJJ's pharmacogenomic research interests are funded by the Pathology Department at the Medical College of Wisconsin.
PJJ has no competing interests to declare. NCB serves on the Speakers Bureau and Advisory Board of King Pharmaceuticals, Pfizer Inc. and Forest Pharmaceuticals.
PJJ and NCB drafted, read and approved the final manuscript.


text:
America's First Electric Supercar
by Mike Daly
When the 2010 Los Angeles Auto Show opens to the public this Friday, visitors will be bombarded by an unprecedented barrage of "green" cars. The success of highly efficient diesel platforms like Audi's TDI and independent electric upstarts like California-based Tesla Motors has a majority of the industry's major players investing in alternative powertrains, many of which will be publicly displayed for the first time. But while the likes of Nissan and Chevrolet will vie for consumer interest with demonstrative front-and-center displays for their respective Leaf and Volt electric cars, far more interesting and groundbreaking fare lies in the depths of the L.A. Convention Center's Kentia Hall, the relative basement that always plays host to the show's minor players, that is, tire companies, aftermarket manufacturers, and…ahem…magazines. Nestled among these booths, North Carolina-based Li-ion Motors will be offering the first public glimpse of their new electric supercar, the Inizio.
Fresh from an industry insider's presentation at last month's SEMA show in Las Vegas, the Inizio makes a rather bold claim as America's first and only 100% homegrown battery-powered supercar. Sure, the respectable Tesla Roadster is distributed from the U.S., but with a chassis produced in England and a body made in France, the Roadster can hardly claim to be authentically and exclusively American.
Green fanatics may recall Li-ion (which rhymes with ion, as in the lithium ion batteries that are the company's stock-in-trade) as one of the winners of this year's Automotive X-Prize, the Progressive Insurance-sponsored contest that awards major prizes to the most energy efficient and promising new electric cars. While the $2.5 million that Li-ion took home for their efforts was probably just a drop in the bucket of what has surely been millions of dollars and years of R&D, the victory provides the company the kind of positive publicity that money just can't buy, and gives Li-ion an instant veneer of credibility in developing a feasible all-electric supercar.
Considering the spate of independently produced supercars that have metaphorically crashed and burned over the last few years, many of which lacked an external design appealing enough to warrant their price tags, the Inizio does carry some aesthetic promise beyond its technological merits. Li-ion's Product Development Engineer and Team Leader Ron Cerven penned the car's design, and it is clear that his resume of racecar driving, aerospace engineering, and car design for Hollywood productions (including Gone in Sixty Seconds and the Austin Powers franchise) has informed his vision of a supercar. The Inizio is exotically attractive without being over the top, and clearly favors soft throwback curves to hard edges and angular wedges. In fact, with its removable hardtop and its arrest-me red paint finish, the Inizio bears at least a passing resemblance to the Ferrari F50 or the Porsche Carrera GT, although seemingly channeled through the fit and finish parameters of early 90s Japanese supercars.
Li-ion claims the Inizio can reach 60 mph from standstill in 3.4 seconds, and has a top speed of 170 mph, numbers that certainly compare favorably to the Tesla Roadster (3.7 seconds 0–60 mph, top speed of 125 mph). Regenerative braking feeds power back to the batteries, which at full charge are theoretically good for 250 miles. With its large dimensions, vertical doors, Recaro seats, and an alcantara interior, the Inizio would certainly seem to be more in the vein of a Ferrari than Tesla's little Lotus of an electric car. Li-ion hopes to launch the car in the middle of next year with a pricetag of $139,000, but bearing in mind the delays and teething problems that far better-publicized efforts have endured (the Fisker Karma and Tesla Model S come to mind), that schedule might be a tad optimistic. Nevertheless, the Inizio's packaging and performance should give highline sports car manufacturers like Audi and Mercedes-Benz an even more pronounced kick in the butt to get their various electric cars, like the R8-based e-tron and SLS-based E-Cell, off the ground and into high gear.
Longines: Defining Elegance for Nearly Two Centuries
By Andre Frazier
Have A (Very) Happy Holiday With Some Spiked "Haute" Cocoa
By Michelle Won


text:
Q: searching for a phrase in Mongodb: weird behaviour i have the following collection:
books> db.books.find()
[
  {
    _id: ObjectId("61ab85b0056b5357b5e23e6b"),
    fields: 'hello good morning'
  },
  { _id: ObjectId("61ab85b5056b5357b5e23e6c"), fields: 'good morning' },
  {
    _id: ObjectId("61ab8679056b5357b5e23e6d"),
    fields: 'hello good morning guys'
  },
  {
    _id: ObjectId("61ab8684056b5357b5e23e6e"),
    fields: 'good morning guys'
  }
]

Then, i run this query:
db.books.find({$text : {$search : "\"good morning\" hello"}})

and i get:
[
  { _id: ObjectId("61ab85b5056b5357b5e23e6c"), fields: 'good morning' },
  {
    _id: ObjectId("61ab8684056b5357b5e23e6e"),
    fields: 'good morning guys'
  },
  {
    _id: ObjectId("61ab85b0056b5357b5e23e6b"),
    fields: 'hello good morning'
  },
  {
    _id: ObjectId("61ab8679056b5357b5e23e6d"),
    fields: 'hello good morning guys'
  }
]

Can you help me to understand the output? The first result doesn't make much sense to me (document _id : ...23e6c), as it doesn't contain the "hello" string.
I read the first answer to this question. Does it mean that, in my case, mongodb is searching for
(good morning) AND (good OR morning OR hello)

It would explain my question, but i can't find the exact reference to this in the mongodb documentation
Thanks in advance

A: Directly from the docs:

A string of terms that MongoDB parses and uses to query the text index. MongoDB performs a logical OR search of the terms unless specified as a phrase. See Behavior for more information on the field.

This is just the behavior a text index allows, What you can do it mark every single expression as a "phrase", like so:
{$text : {$search : "\"good morning\" \"hello\""}}

This will enforce $and logic.

redpajama_set_name: RedPajamaStackExchange


It's supposedly opening the country to hacking risks.
It's now clearer why the UK is jittery about Huawei's alleged security risks. Reuters sources have learned that officials are worried in part due to Huawei's use of an old version of Wind River's VxWorks, a real-time operating system. The version Huawei is using for its telecom hardware will reportedly lose access to security updates in 2020, theoretically exposing British equipment (which will see service well past then) to attacks. The insiders said there wasn't any evidence the use of old software was deliberate, but that's clearly not enough to completely reassure the oversight board looking into Huawei's practices.
Wind River couldn't comment on Huawei's specific situation. However, it said it frequently assisted with software upgrades. Huawei itself wouldn't comment on the details of the report, although it promised to address any of the UK's complaints.
The UK hasn't been as anxious about Huawei equipment as the US government, which has repeatedly urged people to avoid using the company's devices. There also hasn't been tangible evidence of Huawei using security flaws and backdoor software to eavesdrop on behalf of Chinese intelligence. However, the attention to VxWorks shows just how nervous some Western countries are -- they're concerned that even the slightest misstep on Huawei's part might enable Chinese spying campaigns.
It's part of a trial that could rethink medicine.


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Three years ago, I posted this recipe for black bean brownies. I re-post it today with a new topping idea in time for Valentine's Day! I took these (the strawberry version) to a luncheon today, and was reminded how nice it is to have a delicious treat, with no headache afterward. These are a little pudding-ish in the texture, not too rich, and pretty mellow with the deep chocolate flavor and the lightly sweet, whipped cream cheese on top. Use a little milk (any kind) to thin the frosting enough so that it will flow out of the bag easily. I left mine a little too thick today, so it wasn't as controllable. Using the berries for color adds to the "realness" of this whole-food dessert.
I've been on a mental rant today, I'll fill you in on the whole conversation soon. Just suffice it to say that, as a rule, I encourage clients to focus on adding good things to their diet instead of focusing on removing things, and over time they find that the less desirable foods will fall away. That said, at some point you need to give your taste buds a chance to re-acclimate to real. If you haven't already experienced it, you'll be amazed at how much your taste buds will "normal out" when you stop eating junk food. But in order to do that, you have to add in the good yes, but also make a commitment at some point to leave the empty calorie, refined, artificial color and flavor, food science mish-mash alone. (Can you hear the rant coming on?) I decided that just before Valentine's Day wouldn't be a fair moment to give you the whole thing! But it's coming!
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text:
New systems that monitor a driver are coming to the auto industry according to CNN
Systems that monitor the driver
WHY THEY'RE USEFUL:
To improve safety by detecting when a driver is distracted or in distress
WHO'S WORKING ON THEM:
Audi, Mercedes, major universities, app developers
WHEN WILL THEY HIT THE ROAD?
In one to two years
We humans are flawed drivers. We sometimes get behind the wheel while sleepy or even drunk, and we're easily distracted, whether by our electronic devices or something pretty outside our window.
In the gravest circumstances, we can even have a stroke or heart attack behind the wheel.
This is why researchers, app developers and car companies are developing technology to monitor flesh-and-blood drivers and help them avoid accidents. Advanced sensors in the passenger cabin can monitor a driver's vitals such as heart rate, eye movements and brain activity to detect everything from sleepiness to a heart attack.
Nissan is experimenting with an array of technology that detects drunken driving. A sensor in the transmission shift knob can measure the level of alcohol in a driver's sweat, while the car's navigation system can sound an alarm if it detects erratic driving, such as weaving across lanes.
The University of Leicester is working on a system that aims LED lights at the driver to track their eye movements and determine if they are paying attention to the road.
But even awake and alert drivers can get distracted. Audi is testing an attention guard that uses cameras to monitor the driver's head position. If a driver looks away from the road for too long and the car's sensors see it is coming up on another vehicle, the car will sound an alarm and even slow down to prevent a collision.
"The overall objective is to keep you safe, to keep you moving," says Mohan Trivedi, director of UC San Diego's lab for intelligent and safe automobiles, who has worked with Audi on the technology. "One of the other things is a stress-free, enjoyable ride for the driver."
Then there are systems that use sensors to keep tabs on a driver's health. Ford has teamed up with health-tech companies on a glucose reader that alerts diabetic drivers when their blood-sugar level drops. Ford also has developed external sensors that can detect high pollen counts and monitor an asthmatic's breathing.
At the Nippon Medical School in Japan, researchers are testing electrocardiograph sensors in the steering wheel that can pick up early signs that a driver is having a heart attack.
It will be a few years before most of these technologies appear inside production vehicles. But third-party apps on phones and wearable devices, such as fitness bands and Google's Glass eyewear, could become commonplace much sooner.
For example, DriveSafe is a Google Glass app that uses the headset's built-in accelerometer to detect when a driver's head falls. It also employs infrared sensors to count eye blinks and can sound an alarm if it detects the driver is falling asleep.
All this monitoring technology may seem creepy to people who are sensitive to digital privacy. And the potential exists for annoying false alarms. But if it works properly it could make our cars, and highways, safer.


text:
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At the risk of sounding cliche, I had the privilege of reviewing yet another solo festival at the Whitefire Theatre, currently the largest SoloFest on the west coast.
This was a one-woman show, "#METOO," starring Star Stone, and directed and developed by Jessica Lynne Johnson. Cue the klieg lights! A star, or should, I say a Star Stone is born! With a minimalist set and clad in black leotard and leggings, Star starts with a childhood memory of sexuality and performs candid vignettes of her struggle with identity, healthy sexuality, taboos, etc. She masterfully interlaces each with different characters such as: "Rebel-punzel and Cody-dependent." One character after another with brilliant dialogue and media presentation amplifying each vignette. With the mark of a great actor, she inhabits each of the 25 characters, giving each its own posture and dialect and morphing into them seamlessly. Star also gives a "real" sense of what a woman is without relying on cliches with a 'no-holds barred" energy, never needing to be vulgar just: honest.
Although the audience was mostly women, there were a few men lucky enough to witness this amazing show.
It feels like witnessing a phD level thesis, far beyond entertainment entering the realms of a brilliant TED talk: explaining the societal implications of sexual consent for women and men. She injects just the right amount of humor weaved through the trauma transcending any foray into victimhood. Her journey seeks self-realization through experiences, including cuddle parties, yoga, meet up groups all the way obliterating any taboos. She doesn't resort to demonizing men, rather she addresses the cultural shift, the revolution/movement, #METOO now present. She gets the zeitgeist! At the Q & A following the show she said, "…all that happened in real and in life," adding that she wishes to create a show for teens and hopefully Broadway.
This fantastic creation is made for Broadway, do not miss this rising star named appropriately, Star Stone!


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Director of Marketing - University College
Director of Marketing - University College - (19001462)
Director, Marketing for University College
Tufts University's University College is dedicated to developing and offering interdisciplinary degrees and certificates as well as university-wide programming that serves learners of all ages and varied learning interests. Today, University College's programs include Summer Session, Winter Term, year-round continuing education and courses for non-degree students, Tufts Pre-College Programs, short-term abroad, and Tufts Osher Lifelong Learning Institute. The department is expected to grow substantially in the future to include custom / professional education, Pre-k through 8 programs, English Language Learning, and interdisciplinary degrees and certificates. University College offers a fast-paced, nimble environment made of highly-trained professionals who love the higher education environment and are committed to providing world class education in the 21st century to a wide variety of students. University College is well-positioned to develop a distinctive presence in the greater Boston landscape as part of a diverse and accessible institution that makes learning and engagement with education of all kinds for all people a part of its core mission.
The Director of Marketing owns and implements the marketing strategy for University College and its affiliated programs, developing and implementing a comprehensive and tailored strategy that meets or exceeds target enrollment goals within budget. Responsibilities include strategy development in collaboration with program owners and key stakeholders, vendor management, and ownership of the College's media plan, website, social media, email builds and strategy, and CRM. The position is responsible for developing and maintaining a detailed budget in line with allocated spend. Manages the enrollment nurturing strategies for University College, coordinating the development of program-specific content in-line with the content calendar and tailoring marketing content to meet the needs of post-admit students. Develops and manages a strategy for University College program alumni, working with Directors and Program Directors to meet their needs and establish regular communication patterns, being sensitive to cross-marketing opportunities. The position engages with the rest of the department as a team player, ready to help where needed, problem solve, and work towards the greater good of the University as a whole. This position is for someone who gets things done, who has an all-hands-on-deck mentality, and is comfortable having clear performance targets and being measured against them on a regular basis.
Owns the development and implementation of fully integrated enrollment marketing strategies to enroll students in University College and affiliated programs and actively engage a wide range of internal and external constituencies (e.g., students, parents, alumni, partners) and develops and manages a program budget; all in line with program goals
Develops and manages a marketing budget
Works closely with the Program Directors, Marketing Vendor, and school-based stakeholders, oversees and / or completes the content development and delivery for enrollment marketing initiatives including email marketing, newsletters, landing pages, presentations, social media marketing, paid advertising, videos, print and other collateral; and identifies and manages relationships with external vendors and agencies.
Tracks and evaluates the performance of marketing activities, reviewing key performance indicators (KPIs) to drive improvements to the marketing plan. Interprets metrics and analytics requested from vendors and University Communications & Marketing to inform strategic decision making; reports out on metrics and analytics regularly to key stakeholders
Develops and implements email content and campaigns for specific audiences or processes not served by the vendor, including but not limited to process emails, Tufts channel emails, post-enrollment emails, and alumni emails as well as internal communications about University College (within UC and within the university)
Updates, maintains, and develops content for program websites and social media. Advocates for and facilitates placement of program content on university and school-based websites, social media, and related assets.
Establish and maintain collaborative relationships with academic departments, faculty, student life staff, advisors and administrative units. Work collaboratively and as a team player with the rest of the University College team. Host regular progress update meetings with all key stakeholders
Assess and refine programs through continuous improvement processes.
Bachelor's degree and 7-10 years of experience in a professional marketing strategy role
In-depth knowledge of digital, email, and influencer marketing and demonstrated ability to identify and target new markets.
Experience developing marketing plan and media spends with a proven ability to exercise sound, data driven decision making.
Excellent critical thinking skills; ability to manage and evaluate competing priorities and juggle multiple tasks to completion.
Superior organizational skills and ability to manage and execute multiple projects.
Excellent writing and copyediting skills.
Experience working as an individual contributor with the ability to execute the day-to-day, while working collaboratively across the school and larger university.
Experience with Google Analytics, social platforms (Facebook, Twitter, Instagram, LinkedIN), Microsoft Office Suite
Experience with at least some of the following: Hubspot / Pardot / Salesforce CRM / SLATE (or similar), Drupal (or similar), basic graphic design software
Must have a sense of humor, a positive attitude, be collaborative and a team player
10-15 years of experience in a professional marketing strategy role
Relevant experience in consumer products or higher education
Equal Opportunity Employer - minority/females/veterans/disability/sexual orientation/gender identity.
Primary Location: United States-Massachusetts-Medford/Somerville
Job: Communications and Marketing
Organization: Office of the Executive VP
Employee Status: Regular Schedule: Full-time
Job Posting: Jun 5, 2019, 5:16:58 PM
About Tufts University
Tufts is a leader in American higher education, distinctive for its success as a moderately sized university that excels at research and providing students with a personal experience. Our unique combination of research and liberal arts attracts students, faculty and staff who thrive in our environment of curiosity, creativity and engagement.
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text:
Coffee for Minutochku: Starbucks may start accepting bitcoins
bitcoin/
At the end of last year, the official one from Starbucks in Argentina in the placement of the script Coinhive, which is extracted from Monero without the knowledge of device owners.
Now the situation has changed: Starbucks can officially start the sale of drinks . The company entered into an agreement with the cryptocurrency payment platform Bakkt, designed by the owner of the stock exchange of new York (ICE) in partnership with Microsoft. About it writes .
Where to buy goods for you!
As the newspaper notes, the coffee giant, along with McDonalds at the time, played a major role in the spread of electronic payment system. Now came the turn and cryptocurrency.
Bakkt will allow companies to accept the cryptocurrency, not breaking the law. In fact, Starbucks will not work with Bitcoin. The system will automatically convert the coins into Fiat, but at the expense of the company do the usual$.
As the flagship retailer, Starbucks will play a crucial role in the development of practical, reliable and regulated applications for consumers, which will allow you to convert digital assets into dollars, then use them to pay for services. As a leader in mobile payments, Starbucks is trying to innovate and expand the capabilities of their 15 million customers.
When Starbucks will start accepting bitcoins, not disclosed. Let's hope this will happen soon — then other companies will start working with cryptocurrency. In this case, the growth of the market will not need the adoption of the ETF.
Two bitcoinBitcoin
Rally Bitcoin — deception. Well-known economist advises to invest in gold
Director of Euro Pacific Asset Peter Schiff does not see anything supernatural in growth . Recall that the main cryptocurrency has already risen by 179 percent since the beginning of 2019 and is now trading at the level of $ 8540. According to Schiff...
May 2Miners: run pools Aeternity, the debut 2CryptoCalc and software upgrades
the Last month of spring proved to work. The team started working on launching (AE), the addition of which the majority voted representatives of the community. Calculator profitability of mining Alexei Rubin moved to the domain and now will develop e...
CRYPTOMACH / Maximum exchange rate of Bitcoin in the future, the output of the crypts on the map, Ycash and the Board of Finance
the long-awaited summer. Niche cryptocurrency supported the event and gave unusually hot week. During the last seven days, we learned about the new line of graphics cards from AMD, the mining in TON and hard forks . In addition dealt with the profita...
In February, the first Deputy Chairman of VTB Olga Dergunova positively the prospects of the blockchain. According to her, the technology will improve the speed of transactions and security standards. To move from words to action ...
Hacker 1337. How to hack Etherscan not to cause any harm
Monday on the website Etherscan.io appeared a pop-up message with the numbers 1337. The visitors began to panic and spread rumors about hacking Explorer. really hacked, but the damage from a hacker attack was zero. About it writes...
Who is bitcoin? "Irkutskenergo" rent of 14.8 Megawatts of electricity for mining
In January, private investors in Russia for the first time two whole plant for mining. It was about Kizelovskaya GRES in the Perm region of the 23.6 MW CHP and Sarapul in Udmurtia 10 MW. The new owner has no plans to launch produc...


text:
WWF WrestleMania (también conocido en las consolas como WWF WrestleMania: The Arcade Game) es un videojuego de lucha libre profesional desarrollado por Midway Manufacturing Co. (ahora Midway Amusement Games, L.L.C.) en 1995. Está basado en la promoción de lucha libre World Wrestling Federation (WWF). Está disponible para las consolas de Arcade, Mega Drive, SNES, PlayStation, Saturn, DOS y Sega 32X

Jugabilidad
A pesar de ser sobre la lucha libre profesional, WrestleMania es convertido a digital y con movimientos más rápidos como en un videojuego de lucha. Además, es inspirado en la serie de Mortal Kombat. El juego se considera uno de los mejores movimientos de esa época. Es muy similar a Mortal Kombat y el ganador será por medio de dos o tres rondas.

WWF WrestleMania cuenta con dos modos para un jugador: por el Campeonato Intercontinental de la WWF y por el Campeonato de la WWF. En modo por el Campeonato Intercontinental, el jugador debe ganar una lucha Single, dos Tag Team, y un Handicap: Uno contra Tres para ganar el título. El modo por el Campeonato de la WWF, el jugador debe ganar cuatro Handicap de: Dos contra Uno, dos Tres contra Uno, y finalmente llegar al "WrestleMania Challenge," debe derrotar a las superestrellas en un Gauntlet Match, iniciando con un Tres contra Uno, donde cada uno va siendo eliminado hasta llegar a ocho.

El juego tiene dos modos multijugador: Single Match entre dos jugadores, Tag Team Match donde dos jugadores son compañeros en el WrestleMania Challenge en cual derrotar a ocho superestrellas en total y ser los nuevos Campeones en Pareja de la WWF.

Los comentaristas del juego son Vince McMahon y Jerry Lawler.

Puertos
El videojuego ha fue lanzado para las consolas de Arcade, Mega Drive, SNES, PlayStation, Saturn, DOS y Sega 32X.

La versión para Mega Drive conservan los sonidos que aparecen y permite cuatro jugadores en el mismo ring. Sin embargo, la velocidad de fotogramas se redujo a 30 FPS en el puerto de 32X en comparación a 60 FPS en todas las demás versiones.

Para el formato CD-ROM (PlayStation, SEGA Saturn y DOS), las versiones tienen un aspecto más similar a la de Arcade, pero los gráficos no están siendo tan fuertes y los sprites son ligeramente más pequeñas. Tampoco hay música en el juego en los puertos de PlayStation y Saturn. La PlayStation y puertos de Saturn también pueden congelar por un momento durante el juego para cargar la siguiente superestrella para en un Battle Royal después de un personaje ha sido eliminado.

Roster
 Bret Hart
 Bam Bam Bigelow
 Doink the Clown
 Lex Luger
 Razor Ramon
 Shawn Michaels
 The Undertaker
 Yokozuna

Campeonatos
 Campeonato de la WWF.
 Campeonato Intercontinental de la WWF.

Referencias

Enlaces externos

 WWF WrestleMania: The Arcade Game at GameSpot

Videojuegos de WWE Wrestlemania
Videojuegos para PlayStation
Videojuegos para Sega 32X
Videojuegos para Sega Mega Drive
Videojuegos para Sega Saturn
Videojuegos para DOS
Videojuegos arcade
Videojuegos de Midway
Videojuegos de 1995

redpajama_set_name: RedPajamaWikipedia