text:
New Horizons in Cancer Biology
Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking
Megan I. Brasher, Shawn C. Chafe, Paul C. McDonald, Oksana Nemirovsky, Genya Gorshtein, Zachary J. Gerbec, Wells S. Brown, Olivia R. Grafinger, Matthew Marchment, Esther Matus, Shoukat Dedhar and Marc G. Coppolino
Megan I. Brasher
1Department of Molecular and Cellular Biology, University of Guelph, Guelph, Ontario, Canada.
Shawn C. Chafe
2Department of Integrative Oncology, BC Cancer Research Institute, Vancouver, British Columbia, Canada.
Paul C. McDonald
Oksana Nemirovsky
Genya Gorshtein
Zachary J. Gerbec
Wells S. Brown
Olivia R. Grafinger
ORCID record for Olivia R. Grafinger
Matthew Marchment
Esther Matus
Shoukat Dedhar
3Department of Biochemistry and Molecular Biology, Faculty of Medicine, The University of British Columbia, Vancouver, British Columbia, Canada.
Marc G. Coppolino
ORCID record for Marc G. Coppolino
For correspondence: mcoppoli@uoguelph.ca
DOI: 10.1158/1541-7786.MCR-20-0527
Invasion of neighboring extracellular matrix (ECM) by malignant tumor cells is a hallmark of metastatic progression. This invasion can be mediated by subcellular structures known as invadopodia, the function of which depends upon soluble N-ethylmaleimide-sensitive factor-activating protein receptor (SNARE)-mediated vesicular transport of cellular cargo. Recently, it has been shown the SNARE Syntaxin4 (Stx4) mediates trafficking of membrane type 1–matrix metalloproteinase (MT1-MMP) to invadopodia, and that Stx4 is regulated by Munc18c in this context. Here, it is observed that expression of a construct derived from the N-terminus of Stx4, which interferes with Stx4-Munc18c interaction, leads to perturbed trafficking of MT1-MMP, and reduced invadopodium-based invasion in vitro, in models of triple-negative breast cancer (TNBC). Expression of Stx4 N-terminus also led to increased survival and markedly reduced metastatic burden in multiple TNBC models in vivo. The findings are the first demonstration that disrupting Stx4-Munc18c interaction can dramatically alter metastatic progression in vivo, and suggest that this interaction warrants further investigation as a potential therapeutic target.
Implications: Disrupting the interaction of Syntaxin4 and Munc18c may be a useful approach to perturb trafficking of MT1-MMP and reduce metastatic potential of breast cancers.
Mol Cancer Res 2022;XX:XX–XX
Revision received November 18, 2020.
Published first December 6, 2021.
©2021 The Authors; Published by the American Association for Cancer Research
This work is licensed under a Creative Commons Attribution-NonCommercial-NoDerivs International 4.0 License.
This OnlineFirst version was published on December 21, 2021
You are going to email the following Syntaxin4-Munc18c Interaction Promotes Breast Tumor Invasion and Metastasis by Regulating MT1-MMP Trafficking
Mol Cancer Res December 21 2021 DOI: 10.1158/1541-7786.MCR-20-0527
PLK4 Is HIF1α Target Gene
Heme Sequestration for Suppressing Both ADC and SCC
Suppressing LSD1 to Target Mesenchymal Phenotype in MPM
Show more New Horizons in Cancer Biology

redpajama_set_name: RedPajamaCommonCrawl


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The Southern Food & Beverage Museum, Pacific Food & Beverage Museum, and The Museum of the American Cocktail host a variety of programs in New Orleans, Los Angeles, and beyond. See the following schedule for upcoming cooking classes, dinners, seminars, talks, tastings and more.
Interested in booking your next private event at the amazing Southern Food & Beverage Museum? Learn more here!
Filter by location or tag: Louisiana California Cocktails Library Kids Programs
In the SoFAB Kitchen with George Graham
Southern Food & Beverage Museum 1504 Oretha Castle Haley Boulevard New Orleans, LA, 70113 United States (map)
Join the Southern Food & Beverage Museum to welcome cookbook author George Graham. George will be demonstrating recipes from and signing copies of his new, highly anticipated book Acadiana Table.
The Acadiana region of southwest Louisiana, where this unique cuisine has its roots, is a journey into a fascinating culinary landscape. Filled with many of the standard dishes expected in a Louisiana cookbook, Acadiana Table also includes brand new recipes, techniques, and an exploration into the culture, geography, and history of this distinctive area. Fans of Louisiana are sure to love this cookbook, even if they've been cooking Creole and Cajun for years.
Demonstration begins at 2 PM in the Rouses Culinary Innovation Center by Jenn-Air, samples are first come first serve. Free with museum admission.
Born into a restaurant family and a former restaurateur himself, he has written about Cajun and Creole cuisine for newspapers, magazines, and he has been a finalist on television's Food Network Challenge.
In 2013 he launched the blog Acadiana Table: George Graham's Stories of Louisiana Cooking and Cajun/Creole Culture, which already has been a finalist for Best Food Blog: Regional Cuisine in Saveur magazine's 2014 Best Food Blog Awards and also for Best Food Blog in the 2015 IACP Digital Media Awards.
Posted in Southern Food, Demo Kitchen
Tagged New Orleans, Louisiana, George Graham, Acadiana Table, Cooking Demonstration
In the SoFAB Pantry with Cassandra Harrell
Enter the SoFAB Cookie Contest!


Bronze wall plate 54012 series, it represents two central daisies and is useful to decorate gravestones and tombs. This decoration measures 28cm - 11in height and 11cm - 4,3in width. All decorative plates are wall attached.


"In Whatever Time We Have"
Scott Coulter - Scott Coulter , (January 2002) sung with Debbie Gravitte.
John Barr - See link for full page on John Barr and his Schwartz-related recordings, including this song.
It was the fall of 1997. The creators of the stage musical CHILDREN OF EDEN - Stephen Schwartz and John Caird - were working diligently to complete the final changes to a show first conceived in the mid- eighties as a commissioned work under the title FAMILY TREE.
Opening night arrived and the verdict was in; the spectacular production at the Paper Mill Playhouse in New Jersey was a smash hit with both audiences and critics alike. Peter Filichia of The Star Ledger called it "One of the most profound and intelligent musicals ever written." Since that time this wonderful musical has gone on to capture the imagination and hearts of audiences all over the globe.
No doubt its popularity is in part due to the familiarity of the story, the colorful and dramatic production values often incorporated into the show, and its universal themes. Frequently, however, what resonates most with people is its strikingly powerful score by Stephen Schwartz that brings all of these elements to life. Many of its songs have found a life beyond the show; "The Spark of Creation," "Stranger to the Rain," and the title song amongst others, have been favorites of performers and fans of the show.
in whatever time we have"
Then I feel your hand in mine/and there's courage in my heart"
It's not easy to be sure/it's not easy to believe"
The original orchestration by David Cullen had an eighties pop/rock feel to it complete with synthesizer, electric guitar and wailing saxophone. Both the music and the lyrics were somewhat modified for the Paper Mill show. The accompaniment figure was rewritten and the new orchestrations by Bruce Coughlin relied heavily on acoustic guitar and flute giving the song more of a folk quality.
And at least we'll be together/In whatever time we have"
A more recent recording of the song can be found on THE STEPHEN SCHWARTZ ALBUM released on the Varese Sarabande label in 1999. This is perhaps the best-sung version with Brian d'Arcy James and Luba Mason as the vocalists. James in particular brought his trademark vocal power and range to the piece. David Siegel, the album's orchestrator, chose an even more acoustic-based sound using harp, guitar, strings and in fact a full orchestra. As well, musical director Todd Ellison keep the song at a much slower tempo compared with the other recorded versions giving it an almost anthem-like feeling.
It's interesting to note that the song has found life outside of the show. In particular it's a popular piece frequently sung at weddings. Additionally, the song has also been a source of comfort for individuals and their loved ones as they cope with painful and difficult circumstances such as terminal illness.
"In Whatever Time We Have" is arguably one of Stephen's most beautifully written, openly passionate songs. The sincere simplicity of this compelling song will inevitably yield many more performances and recordings by artists who've been touched by its moving message.
HOW COULD I LIVE IN A WORLD WITHOUT YOU ...?
IN WHATEVER TIME WE HAVE.
About Composer - Lyricist Stephen Schwartz.
You're visiting MusicalSchwartz.com, an independent resource site on Broadway and film composer-lyricist Stephen Schwartz and his musicals Wicked, Godspell, Pippin, Disney movies, and others. This site by Carol de Giere offers information, tips, and products through affiliate programs.
Copyright © 2000–2019 Scene 1 Arts LLC, 10 Library Place #909, Bethel, CT 06801. All rights reserved.
Copyright © 2000–2019 Scene 1 Arts LLC, 10 Library Place #909, Bethel, CT 06801. All rights reserved. MusicalSchwartz.com a Stephen Schwartz Fan web site. This independent web site is devoted to the creative career of composer Stephen Schwartz.


Some foods earn a bad reputation they don't deserve. These three foods are fatty, but in a good way!
In a world obsessed with all things thin, foods associated in any way with the word "fat" can be quickly and erroneously consigned to the rendering vat of history. So it is with some degree of jubilation that we reach into that bowl and pluck out three foods that belong back in your diet.
A part of the Western diet for more than 100 years, peanut butter fell victim to the many low-fat, low-calorie diet kicks of the late 20th century. It's true that peanut butter is full of fats. It also packs 100 calories per tablespoon. But sometimes fats and calories are exactly what our bodies need!
Each mouthful of peanut butter provides an excellent source of healthy fats, vitamin E, and the antioxidant selenium. And it tastes good on everything from chicken to chocolate. Some diehards even spread it on burgers and eggs. What's not to love?
Okay, 5 grams of saturated fat for every 8-ounce serving: That's a lot. But whole milk is also rich in protein and nutrients. It's got both fast- and slow-digesting protein. And it's a great source of calcium, vitamin A, and vitamin D.
But as long as you control your total daily fat intake, there's no reason you can't make this classic French creation a part of your diet. If you choose a mayo made with olive oil instead of vegetable oil, you'll also get a big dose of essential omega-3 fatty acids. Yum!
Source: 3 Fatty Foods You're Free To Love!


GiveUpAlready.com > Online Games > Official Kings of Chaos Forum > Catacombs > is it too early to war?
View Full Version : is it too early to war?
would it be advantageous to war early? get those raids going on big accounts before their troops are all trained? getting people to leave alliances knowing their beginning of age growth would almost stop? knowing other alliances would have a huge jump on you and maybe pick up your officers? would it be only something a large alliance should worry about? knowing your opponent is outgrowing you now, and warring now might be to your advantage if you prepare soon enough, knowing they aren't..
we are one week into a new age. is it too soon?
There is only one way to find out and that is by doing it.
Traditionally speaking yes, it is too early to war. But thats just because there isn't a whole lot to sab yet. If you're willing to mass, you can do some damage just fine. If I recall correctly there have been wars started as early as day 1.
I think one age in RF we all trained soldiers straight away and raided PR main as soon as possible, it crippled their age but because of this the war went on for a long time because they had nothing left to lose.
The only down point of an early war are the limited amount turns to pull something big off, the same goes for small alliances that taking on much bigger alliances.


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I study at the University. I want to be a good journalist. I always have my own opinion and the most interesting thing for me – is to share it with other people. My friends always help me. They show me where I make mistakes. I take their critics very constructively. I practice often and time to time as a result - I can see a progress. I like to help to people. This summer I will work for free at the publishing house of my mother's friends. It will be a good experience to me. At my leisure time I read books and play golf. This peaceful sport makes me feel good. Especially when I'm puzzled – I can go to the field, to think and to make my thoughts in order. I like coffee and good tobacco. I enjoy time spending with my family very much.


A child is special to every couple. The news of the arrival of the new-born induces happiness not only in the parents but also the far off relatives. The moment is definitely special as everybody prepares to welcome the arrival of a new member in the family clan. But this happiness often times brings with itself a certain sense of responsibility in the parents. They understand the role that a Pediatrician has to offer when the mother starts to expect. This is when the hunt for a good Pediatrician begins. While there can be innumerable ways to go to about finding the right one, it makes sense to go with the most trusted ones. Here are a few of the representative solutions.
Go with a trusted source: There is a high probability that somebody acquainted to you has had a baby around the time you were expecting. It's best to take their views as they might have done their own research in choosing one. No wonder there research comes in handy for you and you are well on your way to entrust the custody of the new born into a safer pair of hands.
Go with your Gynecologist: Another important source for your search to find ends could be your Gynecologist. Being a representative from the medical fraternity, she should be able to suggest a few pediatricians based on her knowledge. Once you have those names makes sure to call them up, fix up a meeting and narrow down your choice to the best bet. Remember a better pediatrician goes a long way to ensure your child's health and safety so go that extra mile to make the right choice.
AAP or nothing: An important aspect to consider while identifying the right pediatrician is his credentials. Make sure that he is certified by the American Board of Pediatrics (AAP). This certification simply means he is competent at what he does as he has passed a specialized exam related to Pediatrics. Further if a doctor mentions FAAP after his name then that signifies that he is also a member of AAP and that should make you have double faith in him as that simply makes him an expert in child healthcare.
A family Physician or a Pediatric: Though it always makes sense to go with a Pediatric as he possesses the specialized skills sometimes a person wants to proceed with his or her family doctor. This is also to do with the fact that a family doctor has known the family for ages and is familiar with their health history as well as a possible diagnosis. Also another factor which makes a family doctor win over a pediatric is the level of comfort which one enjoys with a family doctor. One clearly understands that besides the child's care they should have a cordial relation with the doctor so everything follows smoothly. In the event that you decide to go with your family doctor, make sure that he is certified by the American Board of Family Medicine (ABFM). This certification simply means that the doctor can take care of patients of all ages including children.
Make hay while the sun shines: You must be wondering why this phrase has been used here. It basically refers to internet as a powerful tool which has simply revolutionized the way the world functions. Any important decision is incomplete if it doesn't have internet as an important source of taking a well informed decision. Use this tool to its optimum to decipher the right pediatrician for you. While many options prevail to ascertain who the right professional for your needs is, the one that stands out is SuperLiked.com. The web address facilitates an individual to rate a person's profession based on his experience. It basically serves as an interface between an individual and a professional, be it a doctor, a lawyer or any other person using his professional services to serve the society. The various testimonials left by the individuals vouch for the credibility of a said professional.


text:
The bullies at Big Gay come after Chick-fil-A -- here's how to fight back
The folks at Chick-fil-A didn't ask for this war, but war has come to them.
The bullies at Big Gay have targeted the "Eat Mor Chikin" chain because its president, Dan Cathy, has taken an unapologetic public stand on behalf of natural marriage, and rebuked this generation for its "arrogance" in thinking that it knows better than God when it comes to the definition of marriage.
And so the heterophobic bigots at Big Gay have come unhinged and unleashed the dogs of war. They've even drafted the Muppets, of all things, as infantry in the effort to wipe Chick-fil-A off the map. The Muppets will no longer allow themselves to be sold as toys in Chick-fil-A kids' meals. Sticking a thumb in the eye of the families you want to buy your products doesn't sound like a shrewd business move to me, but if the Muppets want to shoot themselves in the kneecap, who am I to argue?
Big Gay has also enlisted the anti-diversity, anti-inclusive mayor of the Boston, who has made a NIMBY vow that Chick-fil-A will never be allowed in his city on his watch. In the name of tolerance, you see, he is denying Chick-fil-A its God-given rights under the First Amendment to freedom of religion, freedom of speech, and freedom of association.
But the norma-phobic haters at Big Gay have never let a little thing like the Constitution stand in their way. After all, if the president doesn't, why should they?
The bullies at Big Gay got another notch in their belt by shutting down a bed and breakfast in Canada whose Christian owners chose not to do business with a homosexual couple on the grounds of Christian principle. The owners were pummeled by the cultural thugs on the British Columbia Human Rights Tribunal, forced to pay a fine of $4,500, and forced out of business altogether.
(As a side note to all this, astronaut Sally Ride, who was married to a male astronaut for a time, was outed as a lesbian in her own obituary. She is proof that sexual preference is a fluid thing, and that people are not in fact "born that way.")
There isn't much we can for this Canadian couple who have been deprived of their livelihood by the gay Gestapo, but we can do something for Chick-fil-A. Mike Huckabee is calling for all people of good faith to show their support in the most tangible way: by eating at Chick-fil-A on August 1.
It's a terrific idea. Supporters of natural marriage don't have to wave a banner or a sign, or shout a slogan or anything of the sort. All they have to do is take their family and friends out, grab a Chargrilled Chicken Sandwich with a side of waffle potato fries and wash it all down with some Chick-fil-A lemonade.
Let's make it our goal to buy out every chicken sandwich Chick-fil-A makes on August 1. Trust me, you'll love 'em, they'll just make more, and the nation will get a message about how many Americans support natural marriage. Let's make August 1 the biggest single day in Chick-fil-A history.
By the way, Big Gay isn't going to take this lying down. Or maybe they are. They are planning a giant "National Same Sex Kiss Day" at Chick-fil-A outlets two days later. And they want photos and videos of homosexuals making out in this family restaurant "for all the world to see." Well, maybe some pro-family folks just might oblige them, by taking pictures and videos with their cell phones and plastering them everywhere so all the nation can see just how offensive their behavior can be.
All of this illustrates a singular truth: America must choose between homosexuality and liberty because we cannot have both. Here's hoping America chooses wisely.


text:
#ifdef HAVE_CONFIG_H
# include <config.h>
#endif
#include <stdlib.h>
#include "mailutils/libcfg.h"
#include <mailutils/tls.h>

static struct mu_tls_module_config tls_settings;

static struct mu_cfg_param mu_tls_param[] = {
  { "enable", mu_cfg_bool, &tls_settings.enable, 0, NULL,
    N_("Enable client TLS encryption.") },
  { "ssl-cert", mu_cfg_string, &tls_settings.ssl_cert, 0, NULL,
    N_("Specify SSL certificate file."),
    N_("file") },
  { "ssl-key", mu_cfg_string, &tls_settings.ssl_key, 0, NULL,
    N_("Specify SSL certificate key file."),
    N_("file") },
  { "ssl-cafile", mu_cfg_string, &tls_settings.ssl_cafile, 0, NULL,
    N_("Specify trusted CAs file."),
    N_("file") },
  { NULL }
};

DCL_CFG_CAPA (tls);

redpajama_set_name: RedPajamaGithub


We've been studying Paul in Bible study so far this year and we've just finished going through 1 Corinthians. This verse never ceases to step on my toes…do I really do everything for the glory of God? or is it about me? In my head I know that it is not about me…but my stubborn flesh doesn't want to give up. I am thankful for God's patience as He continues to work with me on this lesson. Daily…moment by moment, I pray that it would all be to His glory!
On sale in the shop this week for $8.
How about you…how do you keep your focus on "doing all for the glory of God" and off of self?


text:
Home Press Releases June, 2010 – Lunch with Lois Frankel
June, 2010 – Lunch with Lois Frankel
Maureen Gross
Palms West Community Foundation
maureen@palmswest.com
(561)790-6200 office
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WOMEN IN BUSINESS SERIES
"LUNCH WITH LOIS FRANKEL"
"Lunch with Lois Frankel"—sold out event!
The Palms West Community Foundation held its second event of the year in their Women in Business series–"Lunch with Lois Frankel", sponsored by Boynton Financial Group. Over 65 leading women from the business community gathered for lunch at Binks Forest Golf Club on June 24, as West Palm Beach's Mayor Lois Frankel, recounted her experiences and insights as a woman involved in the political and business community over the years.
Mayor Frankel began by sharing a brief overview of her life and career as a lawyer, state representative, minority speaker of the house ( the first Democratic woman to hold this position) and Mayor of West Palm Beach, all while juggling her personal life that includes being a daughter, wife and mother. Then, much to the delight of the luncheon guests, Frankel took questions from the audience, displaying her entertaining and humorous ad lib abilities! The questions ran the gamut…from what she plans on doing when her term as Mayor ends in 2011…to what she dislikes most about her job…to what she feels she had to give up, personally, in order to achieve her career goals.
No one left the luncheon early, even as the program ran longer than expected, as Mayor Frankel continued to take questions from the audience. Even Dorothy Frankel, the Mayor's mother, passed her a note to "stop talking, dear", but the crowd applauded as Frankel decided to continue taking questions and to allow her own lunch to get cold. By the end of the day, everyone felt that they had indeed just had lunch with a new friend, Mayor Lois Frankel!
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EHV-1 outbreak
Financial penalties for London horsebox owners
Horse & Hound 25 January, 2007 09:53
Horsebox owners and equestrian traders in Greater London face the prospect of increased costs and hefty fines for missed emissions targets under plans currently being considered by London's mayor, Ken Livingstone.
In an attempt to improve air quality in London — which, according to academics at the capital's King's College, is among the worst in any European city — Mr Livingstone is considering introducing a Low Emission Zone (LEZ) in the city from early 2008.
The zone would cover the entire Greater London area and vehicle owners in each of the city's 32 boroughs would have to comply with the new regulations. The M25 motorway would not fall within the zone.
A Transport for London (TfL) spokesman told Horse & Hound that all vehicles over 3.5 tonnes that do not meet the Euro 3 standard on engine emissions — and most lorries built before 1999 do not — would have to be modified at a cost of around £3,000.
Owners who do not pay for these alterations would face a charge of around £200 every time they drive their vehicle in the zone. Failure to pay the charge would result in a fine ranging from £500 to £1,000.
Caroline Stevenson, chief instructor at Wimbledon Village Stables, has been told by her mechanic that her horsebox, which was registered in 1989, is too old to be modified. She uses it several times a week.
"The cost of purchasing a new lorry is prohibitive," she said, "and paying the mooted £200 fine every time we use our horsebox would mean our riding school could no longer operate. Unless horseboxes are given exemption status then I can't see how riding schools within the zone will be able to remain open."
The TfL spokesman said the zone would be strictly implemented, that there would be no discount for individuals living in the zone and that there would be no exemptions for horseboxes.
"We need people to think about why they are driving their vehicles and what effect it has on the environment," said the TfL spokesman. "All road-going vehicles would have to comply. The only exceptions to this rule are agricultural vehicles, such as combine harvesters."
TfL is currently canvassing public opinion, but views must be registered by 2 February at www.tfl.gov.uk/tfl/low-emission-zone/consultation.asp. The British Horse Society (BHS) contacted all affiliated yards by post earlier this month, encouraging them to do this. A decision on whether or not to implement the zone is expected by the summer.
This news report can be read in full in today's Horse & Hound (25 January, '07)


Recently I attended a conference at which I knew a select few people in attendance. I contemplated not going because of my perceived lack of a social circle. I finally got out of my head and made a commitment to myself to look for people who were in the same boat as myself and make a difference in their lives through friendship.
As I am doing my devotions this morning, I read; " Instead of running away from challenges, embrace them, eager to gain all the blessings I have hidden in difficulties".
Sales are good but profits are down… Something must be out of whack! This situation is one I think a lot of us have experienced at some point or another. It can be truly frustrating, especially when so many aspects of the business are in good shape.
Are you ready to take a major step forward with your business and step into potential that you never imagined existed? Are you looking for someone who will push you out of your comfort zone towards achieving your audacious goals? If you are ready to embark on this journey of dramatic change and growth, than you have come to the right place.
The transition from technician to business owner is not an easy one. Many believe that the key to gaining more customers and becoming profitable lies directly in the quality and speed of the work they produce. In reality the success of their business can be effected by any number of factors that are not at all related to the quality of their work.
Specialize, understand your Key Performance Indicators, give customers extra value, be proud of your store and invest in your staff.
In the past 5 years, the car manufactures have changed their recommendations for how to maintain their vehicles. In the past these recommendations were provided by the engineers who made the car, as a roadmap to make the car last the its maximum potential. However it seem that over these last 5 years instead of the engineers making these recommendations is it now been taken over by the Sales dept. as an promotional tool.


There are literally dozens of questions to consider related to your reredos/altar needs. We will make you aware of situations, concerns, weight limits, color schemes and materials/technologies you would never have thought of until it was too late.
"We are not ready for that yet" is by far the biggest mistake we hear on all sacred space projects. You are building/renovating a sacred space, not a game room or a strip mall. This is God's house, and he is in the details.
King Richard's would be happy to visit your facility to discuss your upcoming renovation, construction or closure. Whether it's a formal presentation to your building committee or a face-to-face sit down to get the ideas flowing, King Richard's consultants can help you walk through the first critical steps in your planning process with confidence.


Best version of one of the worst stock finishes ever. It looks like an old bit of furniture that had white paint over the varnish. Now the lime green, lemon yellow or glowing orange and black crackle is shameful. Someone made a mistake in the finishing process and some marketing person's kid said it was cool. I had to deal with bicycles of that finish during that era. Don't miss that day at all.
The finish is totally at odds with the style of guitar. I think you may be right about the marketing person's kid.
Danelectro annd Axl still do the crackle finish.
I played a Ta-30(japanese) for years and ,yes, they are superb. Been trying to find a new one ever since my original had a nasty accident.
Keep checking eBay - they come up for sale every now and again.
I have that exact same guitar that I bought at a music store in Frankfurt Germany, 1988. Great components and still plays and sounds fantastic!
I still have an Urchin. I can find images of the U60 and the over-the-top U100 but none of the U80 so mine might even be rare. $350 at a pawn shop about 25 years ago.


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Chris Boyer was born and raised in Crystal City, Texas. After obtaining a degree in accounting from Texas A&M University, he enrolled in law school at Baylor University. Chris subsequently obtained his law degree in 1976 and thereafter joined the firm of Crenshaw, Dupree & Milam, L.L.P. Over the years, Chris centered his practice in oil, gas, and mineral law, real estate, and related litigation. He is board-certified in oil, gas, and energy law. Chris is married with two grown children. In his spare time, Chris enjoys spending time with his grandchildren, hunting and fishing.
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On the helideck Samara flaunts her most dramatic features, at the touch of a button or the pilots remote control, the helipad slides aft, the instrument arch slides forward, and the handrails fold down. These motions transition Samara to her flight configuration, this provides a generous touch down area with no trip hazards on deck, and substantial clearance around the rotor disk; ensuring safety during flight operations.
Samara is capable of hosting a selection of helicopters such as the Hughes MD500, Bell 206 or in this case a Robinson R44. Night flying is made possible by landing lights surrounding and below the helipad, these indicate to an airborne pilot that the systems are properly deployed. Spotlights illuminate the helipad in compliment to the helicopters own lighting system. With a 2000 litre refuelling facility, strap down points on the deck, and the ability to remove and stow the rotor blades separately the helicopter has a permanent position on board, even during offshore passage. However, when the helicopter is absent a bimini can be extended from the instrument arch, and the upper deck can be turned into a sun lounge with sun pads.


If you are meeting with your academic adviser because of an academic caution, you will need to complete the Record of Academic Caution/Early Intervention form (PDF, 134kB) and take it with you to your appointment..
The Faculty of Engineering and Information Technology have a list of academic advisers sorted by major on the webpage Program Coordinators.
UTS Business School students who are placed on Academic Caution or Early Intervention will receive notification from the Student Administration Unit Progression team, via an email or letter. This email or letter will contain specific instructions on how to go through the online academic caution process. This online process will be available from 18 February to 8 March 2019 only and accessible 24 hours - 7 days during this period.
Academic Caution appointments are available in 20 minute intervals. To request an appointment please send an email to Law Academic Caution. In the body of your email please provide your name, UTS student number, course title, and three preferred appointment times. Your appointment request will be confirmed via return email as soon as possible.
To request an appointment please email School of Communication Academic Caution from your UTS email account. In the body of your email please provide your UTS Student ID, full name and course title. Your appointment will be confirmed via return email as soon as possible.
Please check your UTS webmail account for details of your academic adviser and their contact details.
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This article discusses some of the changes and clarifications that have been made to the document. There are separate sections identified corresponding to the sections in the Annex.
This section is a typical description of where this document is applicable. However, it also contains some wording about various topics, e.g., contamination control, room qualification, classification, monitoring and gowning (lines 18-20) that would be appropriate to apply to non-sterile manufacturing processes. While true that these topics are useful to other types of manufacturing processes, why would non-sterile manufacturers review this document? Wouldn't it be better to place this type of comment in a document for non-sterile manufacturing, referencing them back to this document?
Monitoring Systems – including an assessment of the feasibility of the introduction of scientifically sound, modern methods that optimize the detection of environmental contamination.
Prevention – Trending, investigations, corrective and preventive actions (CAPA), root cause determination and the need for more robust investigational tools.
Continuous improvement based on information from the above systems (lines 50-54 and 69-106).
The key to this program is the minimization of the risk of contamination (lines 59-62). Another important feature of this program is that it should have a life-cycle approach with ongoing and periodic review and update (lines 56-57). The program should include potential sources of contamination like microorganisms, cellular debris (like pyrogens and endotoxin) and particulate matter (line 64-67).
While we are used to the wording about prohibition of jewelry, wristwatches, and make-up, there is a specific new wording about the prohibition of mobile phones. In some companies the use of mobile phones in cleanrooms and throughout the manufacturing process is excessive. This change could have a significant impact on many companies, if it is in the final issuance of the Annex (lines 236-237).
There is also specific wording that for sterilized gowning must be changed at least for every working session in Grade A and B areas (lines 281-284). For some companies this can be a major change to their processes.
This section provides specific guidance on the use of classified areas, including where airlocks should be used. It further describes the qualification and requalification of these areas. There are similar sections wording the design of cleanrooms as in the FDA GMPs, 21CFR §211.42. It also prohibits sinks and drains from Grade A/B areas (lines 305 – 398).
There is a requirement for the visualization of air flow patterns in Grade A/B areas to determine if the flow is unidirectional. It also discusses that visualization studies may be necessary in other areas based upon risk assessment. Lastly it indicates that the airflow studies should be consulted in determining the environmental monitoring program (lines 412-421).
Sections are included for barrier technologies (lines 435 – 483), Clean room and clean air device qualification (lines 487- 565), which includes all of the tables for particulate levels in each room Grade. One of the interesting things in this section is that although many expected the removal of requirements for monitoring of 5µm particles. However, this did not occur in the draft. There is a new useful column that describes the ISO classification both in operation and at rest (Table 1 starting at line 505).
There is also specific information provided for the initial classification of the minimum number of sampling locations as in ISO 14644-1. While stating this, it also indicates that a higher number of samples and sample volumes are typically required in the aseptic processing room and the immediately adjacent environment (Lines 51—517).
Starting at line 544, there is Table 2, which describes the "Recommended limits for microbial contamination in operation." This table previously had a footnote that allowed for an average of >1 cfu before an investigation be conducted. This footnote (lines 550-551) has been changed to state: "It should be noted that for grade A the expected result should be 0 cfu recovered; any recovery of 1 cfu or greater should result in an investigation." This new wording is consistent with the USA FDA requirements but it a significant change in interpretation for European companies.
Another interesting comment is provided in section 5.30 (lines 563-565). Regarding temperature and humidity, it discusses that these parameters should not interfere with the defined cleanliness standard.
A subsection on Disinfection is included in this section. In section 5.31 (lines 569-578) there is some interesting wording. It says that "more than one type of disinfecting agent should be employed, and should include the periodic use of a sporicidal agent." It is not clear whether this section is stating that rotation of disinfectants is required or if it is sufficient to use a routine disinfectant along with a sporicidal agent. In line 576 it also talks about the "ability to detect the development of resistant and/or spore forming strains." This section is not clear as to whether a specific test method is required or whether monitoring trend analysis to see if so-called sensitive organisms are showing up in the monitoring program. It would be good to have some clarification in this section.
In section 5.32 (lines 580-583) there is wording describing the need to monitor disinfectants and detergents for microbial contamination. It is not clear whether this applies only to non-sterile preparations or also requires monitoring of sterile formulations.
This section requires detailed descriptions of the equipment design, that should be kept up to date (lines 593-595). There is no provision for systems that may not have had been implemented prior to this requirement. As such, it would necessitate companies to "create" these documents for systems that would likely be treated "as built" designs. The design document specifically needs to describe the product, and other critical gas and fluid pathways and controls.
Conveyor belts are discussed in section 6.8 (lines 625-627). This section requires that the belt "cannot go through from a Grade A to Grade B area or other area of lower air cleanliness, unless the belt itself is continuously sterilized (e.g., in a sterilizing tunnel). This wording can be confusing, as it is not clear if the belt must go through the sterilizing tunnel immediately before passing to a lower-class area or not. Additionally, if it must be "immediately" sterilized this could be burdensome for companies to find appropriate systems.
Qualification of particle counters is discussed in section 6.9 (Lines 629-631). This is interesting as many currently believe that calibration alone is sufficient. The Annex does not provide any guidance on what is expected as part of the qualification.
This section describes the requirements for utilities and includes risk assessment, drawings (that are current) and periodic reevaluation of risks.
There is a subsection on water systems starting at line 665. Some of the changes in this part of the annex is an update to talk about the allowances for production of water for injection that is not manufactured utilizing distillation. This is consistent with the changes to the pharmacopeia that make this same allowance.
Section 7.10 (lines 682) is interesting, in that it says: "Water flow should remain turbulent through the pipes to prevent microbial adhesion." While continuous flow is desired, some systems have still had biofilms produced even with continuous flow. More information on the prevention of biofilm formation is discussed in section 7.13 (lines 691 – 696). In this section, a concern arises in that the "water should be analyzed after disinfection/regeneration; results should be approved before the start of use of the water system." For companies that do not use rapid microbiological methods, this could cause a longer shut-down than typically expected awaiting microbiological results to be obtained and approved.
In section 7.15 the annex clearly expects continuous monitoring of total organic carbon (TOC) and conductivity (lines 710-711).
There is a subsection for steam used in sterilization starting on line 713. There are some specific requirements stated for tests that should be conducted for steam in place systems.
Another subsection starts on line 725 covering compressed gases and vacuum systems.
Cooling systems are addressed starting at line 738. This section requires controls to contain spillage and cross-contamination. It also states that: "any leaks for the cooling system must be detectable." For existing systems, it could be difficult to retrofit the system with these types of leak detection methods.
This section specifically describes the requirements for terminally sterilized product, aseptic preparation, finishing of sterile products, sterilization, sterilization by heat, moist heat sterilization, dry heat sterilization, sterilization by radiation, sterilization with ethylene oxide, filtration of medicinal products which cannot be sterilized in their final container, form-fill-seal, blow-fill-seal technology, lyophilization, closed systems, and single-use systems.
This part of the annex contains the bulk of the information.
The terminal sterilization section (starting at line 754) if very consistent with the previous version.
The aseptic preparation section (starting on line 785) is consistent with requirements in the FDA's Aseptic Processing Guidance (2004) and the PIC/s document on Aseptic Processing.
Finishing of sterile products (starting on line 875) specifically requires partially closed containers need to remain under Grade A conditions until it is in the lyophilizer. There are also some specific requirements stated for the "defect library" used in visual inspection processes. It also indicates that automated inspection systems should be as good as visual inspection or better.
The sterilization section (starting on line 953) states that if possible, products should be terminally sterilized. This is consistent with the EMEA decision tree on sterilization methods to use. This section highlights some of the ways quality risk management procedures should be used. There are specific requirements for the use of suitable biological indicators and how they should be used.
Sterilization by heat starts on line 1058. There is a specific section (8.48) which discusses processes for which parametric release is used.
Moist heat sterilization starts on line 1098.
Dry heat sterilization starts on line 1155. It is interesting that there is specific wording (lines 1181-1183) that address endotoxin spiked containers. It includes a specific reconciliation of the spiked units, endotoxin quantification and recovery efficiency to be demonstrated.
Sterilization by radiation starts on line 1206.
Sterilization with ethylene oxide starts on line 1206. It was sad to see that only gas sterilization using ethylene oxide is discussed. There are other acceptable gas sterilization methods available, e.g., ozone, chlorine dioxide, and nitrogen dioxide. These technologies would be a good inclusion.
Filtration of medicinal products which cannot be sterilized in their final container begins on line 1249. Interestingly, in lines 1283-1285 it talks about allowing sterilization procedures that have a SAL of 10-6 or better. It is not clear if this is meant to clarify that you can sterilize post aseptic filling or if there is an expectation of this level of sterility assurance on an aseptic process. It is important to remember that there is no way to calculation the SAL of aseptic products that are not subsequently subjected to terminal sterilization. Lines 1360-1362 discuss the need to discard sterilizing filters after processing a single lot. It also says that the filter cannot be used for more than a SINGLE working day. This may cause some concern for producers of long campaign runs and/or identical product that is filled with the same product but may have different labels (as they may be different lot numbers).
Form-fill-seal starts on line 1364. This section is consistent with existing requirements.
Blow-fill-seal Technology starts on line 1385. This section adds requirements for risk management procedures. It also provides specific guidance for shuttle and rotary type equipment.
Lyophilization begins on line 1450.
Closed systems are discussed starting on line 1492.
Single-use systems are discussed starting on line 1517. It discusses the specific risks associated with this type of system.
The document describes that these programs are part of the overall site contamination control program. These programs are important with respect to maintenance of sterility assurance. This is an interesting section that includes viable monitoring, non-viable monitoring and aseptic process simulations. This section starts on line 1580.
Clarifies the requirements and expectations for use of risk assessment in these processes.
Discusses the need for visualization studies (smoke studies) are important considerations in evaluating the effectiveness of the program.
States "routine monitoring" should be performed in operation, with a few exceptions provided.
Alert levels should be established based upon data and subject to periodic review.
If action levels are exceeded, root cause investigations should be conducted including corrective and preventative actions.
Operational Grade D non-viable particulate levels in operation should be based upon risk assessment.
Monitoring of 5 µm particles is required for routine monitoring. Some provisions provided for occasional "false" data.
Continuous monitoring expected for particles in Grade A areas during operation including set-up. Similar monitoring should be conducted in Grade B areas; may have a lesser frequency.
Continuous monitoring of viable contaminants in Grade A and Grade B areas is expected. For some companies, only periodic monitoring is conducted in these areas.
Line 1735 describes the use of rapid microbiological methods and how they can be adopted.
Lines 1753-1754 also identifies the expectation of 0 cfu in Grade A and B areas. It removes the footnote that allowed for averaging of results.
Lines 1759-1766 provides several specific examples of adverse trends in environmental data. This will be very useful for many companies.
Section 9.33 (lines 1768- 1772) includes requirements for identification of microorganisms.
Aseptic Processing Simulation (Media Fills) is discussed starting on line 1774. Most of this section reflects current FDA and PIC/s expectations. One line is disconcerting (line 1845), which states: "ensuring that any contamination is detectable." Most conventional methods do not have the ability to detect single cells, so it is unlikely that very low levels of contamination are detectable with conventional methods.
Contaminated units in an aseptic process simulation, even 1, is expected to include a root cause investigation and appropriate corrective and preventative actions (see lines 1911 – 1918). It also provides for use of quality risk management in determining the number of repeat studies required.
This section begins on line 1952.
Much of this section describes a variety of controls that should be used. It describes bioburden testing and the need for monitoring on suitable schedules. This document highlights that the sterility test alone is not sufficient to ensure the sterility assurance of the product. This section also requires review of environmental monitoring data as part of batch release.
A comprehensive glossary begins on line 2011. This section is very useful in understanding the document.
Anonymous (2018) Impact of the Annex 1 Revision on Pharmaceutical Water. ECA Academy. Downloaded from: https://www.gmp-compliance.org/gmp-news/impact-of-the-annex-1-revision-o... on February 5, 2017.
Lyons, J. (2014) Annex 1 (Manufacture of Sterile Medicinal Products) Update. Pharmalex. Downloaded from: https://mcgeepharma.com/eur/annex-1-manufacture-of-sterile-medicinal-pro... on February 5, 2018.


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首页 / Learn More / The Seligman Times
Martin Seligman: Prospective Psychology: On creativity and aging, 2014
Bestselling author, world leading psychologist and expert adviser on wellbeing in international public policy, Seligman considers the role of imagination and creativity in shaping the future, and how does this change as we get older?
Roy Baumeister: Prospective Psychology: On free will, 2014
Renowned social psychologist, Professor Roy F. Baumeister, is among the most prolific and most heavily cited psychologists in the world, with over 500 publications. His 31 books include the New York Times bestseller Willpower. Baumeister looks at how we make decisions. Do habits and past events determine our behaviour, or are we able to choose between different imagined futures to create complex plans that can be realised?
Amy Wrzesniewski: Job crafting to create meaning, 2014
by Amy Wrzesniewski, 2014
Rarely are jobs designed to match the talents, preferences, and aspirations of the individual. Dr. Amy Wrzesniewski, professor of Organizational Behavior at the Yale School of Management, discussed the art and science of job crafting. Wrzesniewski studied hospital maintenance workers to look at how job crafting affected their work experience and morale. She set up two groups - one simply followed the job description while the second was asked to take on other, related tasks of their own choosing. Differences between the two groups were significant - the second group found meaning in their work and saw themselves and their purpose as radically different from their counterparts. Allowing an employee to influence work scope changes the meaning of that work, and allows them to take ownership of their job. Wrzesniewski's work shows that job crafting can foster engagement, job satisfaction, and resilience.
George Vaillant: The importance of relationships to health, resilience and aging, 2014
by George Vaillant, 2014
Professor George Vaillant delivers his fascinating lecture: 75 Years in the Making - The Importance of Relationships to Health, Resilience and Successful Ageing at the OnePlusOne Edith Dominian Memorial Lecture.
George Vaillant: TED talk: From emotionally crippled to loving personality, 2014
As a psychiatrist and professor at Harvard Medical School and the Director of Research at the Department of Psychiatry, George Eman Vaillant M.D. has a lot of duties. To add to them, he has been responsible for the Grant Study, the longest longitudinal study of human development ever undertaken. Since 1938, this study has been keeping a very close eye on 200 diverse men.
One of the men, Godfrey Camille, was particularly interesting. Emotionally crippled and lonely as a youngster, Godfrey was accustomed to exhibiting negative coping styles like hypochondria, narcissism and displacement. All of these emotional issues took a toll on him in life, making it difficult for him to truly connect to others. However at the time of his death, he was 82 and in the middle of an active game of squash. At the time of his death, he was a retired medical doctor with his own practice, a devoted husband and an exemplary father. His memorial service was packed with mourning friends. His children described him as a man who lived a very simple life, full of very rich relationships.
Chandra Sripada: Prospective Psychology: On the future brain, 2014
by Chandra Sripada, 2014
Chandra Sripada M.D. holds a joint appointment at the University of Michigan in Philosophy and Psychiatry. He uses neuroimaging to investigate questions in both fields, including the mechanisms of self-control, attention, and planning. In his session, Sripada asks: is thinking about the future a core brain process with its own networks of brain circuitry?
Laurence Steinberg: What Is Bad Parenting?, 2012
by Laurence Steinberg, 2012
An expert in adolescent psychology outlines the main features of bad parenting.
Question: What is bad parenting?
Laurence Steinberg: So when I say bad parenting, I mean parenting that is excessively harsh, parenting that is inconsistent, or parenting that is excessively permissive. And lots of times kids get all three of those things together. So their parents will swing from being really, really harsh and punitive to not even caring, and being what most of us would consider to be negligent. And so those three things, the harshness, the permissiveness and the inconsistency, all have been shown to contribute to antisocial behavior during adolescence.
Laurence Steinberg: Adolescence as an age of opportunity, 2014
Dr. Laurence Steinberg speaks at Chapman University about his book Age of Opportunity. Steinberg uses new research to illustrate why adolescence is a pivotal time in a person's development and life outcomes, as well as what we can do to "raise happier, more successful kids".
Laurence Steinberg: Are millennials lazy, self-absorbed and needy?, 2014
Dr. Laurence Steinberg, Temple University/Age Of Opportunity: Lessons from the New Science of Adolescence, joins Thom Hartmann. We all know the stereotype: the unemployed millennial living at home with his parents, more interested in taking Instagram photos than getting a real job - does this match up with reality? What does Dr Steinberg's research about young people these days tell us about the very concept of adolescence? What about the concept of adulthood?
Laurence Steinberg: The new science of adolescence: Understanding risky behavior, 2013
Adolescence is a time of change and maturation, but with that growth comes risky behaviors like alcohol and drug use and dangerous sexual behavior. What can be done to promote positive behavior among adolescents? Laurence Steinberg will discuss these questions as part of "The New Science of Adolescence: Understanding Risky Behavior." The speaker will look at recent studies that explain unsuccessful efforts to change behavior and what can be done to curb dangerous decisions.
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My instrument stopped working with error E001.
I put the plugin in another mainframe with the same output: E001.
Following troubleshooting in Service Manual i tried to read the ROM content at address 4000. I found 51 instead of 55.
I don't know offhand what address 4000 is, but usually error E001 is a communication error between the plug-in and mainframe.


>> Home , Economics , Is There No Incentive to End Wars & Cure Diseases?
In a system rooted in cronyism, is there any incentive to solve problems rather than protract them?
The United States' political class sold its citizenry a bill of goods: that ending war and disease comes with the destruction of Western economy as we know it.
It's never been said in those words, of course. But it is absolutely spoken through policy and press.
The United States on average has been at peace for about one month out of every year since her inception. Imagine fighting 22 hours a day, every day for 235 years. "Freedom isn't free" is the bromide typically given in response to such an observation; but while freedom doesn't come at zero cost, a damn good case can be made that it doesn't have to come at the cost of $0.52 of every tax dollar received.
The United States went from a country that admonished foreign entanglements, to one that thrives off them. The first and second world wars might have been the tipping point for the US economy. The first precipitated the irrevocable step into foreign entanglements; the second precipitated the economic dependency on said interventionism.
The majority of business for companies like the above comes from the government in one form or another. Despite the hike in defense spending overall, stocks still fell. The power of a peaceful handshake can bring a country built on war to its knees, if it doesn't adjust accordingly.
But peace no more destroys economies than technology. It simply is a cue to redirect economic energy. Yes, some jobs are obsolete due to technology. Yes, some industries will lose profits due to peace. But it's a false choice to say that if that job goes away, a net job was lost. In point of fact, more net jobs were added to replace that job. Same would hold true for all the military spending. Those businesses would get into some other line of goods and services, or their business or industry would become obsolete. The wealth and economic efforts once dedicated to those industries would likewise redirect themselves.
Americans are told these are all preemptive and preventive; that if the US didn't intervene *insert bad thing here*. The Swiss have historically made a good amount of money off wars… not by intervening but by funding. Still, if the world realized peace tomorrow, Switzerland wouldn't cease to exist or even be reduced to a 3rd world status. There are plenty of other services that country offers the world that keeps it economically sound.
I'm sure you've heard the preposterous question: if we ended slavery, who would pick the cotton? If we ended war and stopped criminalizing everything, who would prop up the economy? Absent two of the largest government funded industrial complexes – military and prison – would the United States just collapse into its own footprint like a Twin Tower in summertime? In theory, that wealth would be refunded to the private sector where new industry and wealth could be created.
There are two business models: traffic based and transaction based.
Small ticket items are often the former, while larger ticket items fall in the latter. Having to return to the store for things like food and toilet paper makes sense. This is why those companies don't deviate too far from their generic counterparts' price points. Yes, brand is a little more expensive, but not THAT much more because they know they are going to make their money off the life of the customer… not in ONE transaction.
Transaction models are more like cars and houses. The average person doesn't buy these on any regular basis. They are often very ignorant on the process because of their limited experience. The price points are higher because the durability and sustainability of the product is longer than a roll of toilet paper, plus the actual costs that go into making them is higher.
War and healthcare should not be treated as traffic based models. When you have a government that can tax, print, and borrow to its heart's content, you get this kind of distortion: where violence and protracted suffering become economically normalized.
War is the violent resolution to a dispute or problem between nations. Once a side wins, the war is over, and resolutions are made. The demand for war services and products likewise ceases. That used to be viewed as a good thing, but is now viewed as an economically bad thing.
Healthcare is a little different, but shares a similar conundrum: people have health problems. The medical industry is charged with fixing or resolving those problems. Once someone is fixed or cured, the demand for treatment ceases. This used to be viewed as a good thing, but is now likewise views as an economically bad thing.
In both cases — war and health — the claim is that these industries aren't profitable or sustainable if they ever achieved what they set out to do.
The healthcare industry makes more profits off treatment than cures. The defense contractors make more profits off continued conflict than resolution and peace.
Goldman-Sachs issued a report stating the obvious: cures aren't sustainably profitable. This left many to conclude that the medical industry would not work in the best interests of the patients because there's little to no profit in it.
It's not profitable that small pox and polio have all but been eradicated. There isn't a strong demand in places with plumbing to treat polio. Cures will always be more superior than treatments. If someone came up with a cure for diabetes, insulin producers would be out of business because it doesn't take a fortune teller to know diabetics will take the cure over management regimens.
Then there is the matter of FDA approval. Remember Samuel Girod, the Amish farmer who faced 12 count federal indictment for selling and distributing his non-FDA approved chickweed salve? That scheme was instituted so small players like Samuel Girod never took a customer away from the establishment players.
There is something in marketing called the "Opportunity Model". It is an analysis done on products and services that looks at four major factors of a given brand: Credibility, Relevance, Differentiation, and Anticipation (or Stretch). This evaluation is conducted on a regular basis in most large corporations. They stand the most to lose, so they are always optimizing their brand to ensure these four tenets are met or exceeded in some way.
That this is a common practice with most brands says what about sustainable profits in a market economy? It says they aren't sustainable! It says that without constant optimization, all businesses are unsustainable.
Keeping wars going, keeping people sick, patents and regulations that keep competition at bay… all that is just plain laziness.
Don't buy into the fear propaganda and hype. The truth is, there IS incentive to cure disease. There IS incentive to end war. The same way there IS incentive to automate: it frees up capital for other more lucrative economic activity. The government just needs to get out of the way and stop "helping".
Divestment Part 2 – Where To Go?
Trump is Officially President of the United States: Now What?


text:
Magellan High Conviction Trust (ASX:MHH)
Hamish Douglass
Market Cap (AUD): 1.06B
Sector: Financials
Last Trade (AUD): 0 +0 (+0%)
On 1 July 2021, Magellan Asset Management Limited, a subsidiary of Magellan Financial Group (ASX:MGG), as responsible entity of the Magellan High Conviction Trust (ASX:MHH) announced its intention to transition the Magellan High Conviction Trust from a closed-ended listed investment trust to an open-ended Active ETF to be named Magellan High Conviction Trust (Managed Fund) (ASX:MHHT).
On 31 August 2021, units in the Magellan High Conviction Trust (Managed Fund) began trading on the ASX.


I am listing this boat for a friend. She is a widow and wants the boat sold. This boat is in excellent condition all around. Shed kept most of it's life. Professionally maintained by two local Marine outfits. I will have some other photos and a survey from a few years ago - soon. 350 GM blocks, may have been rebuilt at some point as they run perfect. There is apparently zero rot. Boat is mostly original and has superb natural finished mahogany interior - virtually pristine really. Has a 6.5 Kohler, Norcold 2door/2way. Very limited electronics. Dinghy with 9.9. Fully new canvas a couple of years ago.Tight and solid package overall.Unfortunately she does not want to put it in the water this year, in spite of being advised that not launching her will make the sale much more difficult. Asking $25k but open to offers.


text:
Карта на Карно е графичен метод за изобразяване на булеви изрази.

Този метод, може да иобразява булеви числа и изрази от различна разрядност.

История
Този метод е изобретен през 1953 година от американския учен Маурис Карно в Лабораториите на Бел.

Цифрова електроника

redpajama_set_name: RedPajamaWikipedia


text:
Q: List iteration - Generic logic I have a list of beans (List<AClass>), from which I am creating two sub list based some logic which involves checking a field from the bean class, say action. if
bean.getAction.equals("true") - add to new sublist - List<AClass> listA
else - add to new sublist - List<AClass> listB

I have created a method for it and it works fine.
Now I have similar task for other Bean class as well where i have List<BClass> which also has action field and getAction method. I want to create a generic method which would cater to both these beans (and other similar beans as well).
How can I create such method?

A: Use List<? extends ParentClass> where ParentClass is parent of AClass and BClass

A: If AClass and BClass share a common base then a wilcard type can be used - List<? extends CommonBase>

A: Something like this should work:
interface HasAction {
    public String getAction();
}

public class AClass implements HasAction {
    private final String action;

    public AClass (String action) {
        this.action = action;
    }

    @Override
    public String getAction() {
        return action;
    }

}
public class BClass implements HasAction {
    private final String action;

    public BClass (String action) {
        this.action = action;
    }

    @Override
    public String getAction() {
        return action;
    }

}

public <T extends HasAction> List<T> subList(List<T> list) {
    List<T> subList = new ArrayList<T> ();

    for ( T source : list ) {
        if ( source.getAction().equals("true")) {
            subList.add(source);
        }
    }
    return subList;
}

redpajama_set_name: RedPajamaStackExchange


text:
Vulcanella acanthoxea är en svampdjursart som först beskrevs av Tanita och Kazuo Hoshino 1989.  Vulcanella acanthoxea ingår i släktet Vulcanella och familjen Pachastrellidae. Inga underarter finns listade i Catalogue of Life.

Källor

Horn- och kiselsvampar
acanthoxea


If I could go back in time, I would choose the first century so I could see Jesus as a human being. I would miss certain luxuries of this life, like In-N-Out burgers. But imagine what it would have been like to see Jesus.
I wonder if he ever took a nap and woke to find all the disciples standing there, staring at him.
He was God walking among them. How amazing must that have been?
When you look back over your life, there are certain memories that stay with you. Sometimes they're childhood memories. Sometimes they're bad memories. Sometimes they're very wonderful memories. But there is something about certain experiences in life that are permanently etched in your mind, and you can recall them instantly. You remember the feeling. You remember the sound. You remember the smell. You remember details.
Basically, John was saying, "Look, we walked with him. We talked with him. We remember the timbre of his voice. We remember the color of his eyes." By the way, they never told us the color of his eyes or hair or skin. That doesn't matter, because Jesus Christ came for all people.
Jesus walked this earth, but some would assert that it's all fiction, that it's just something Christians made up. It's an undisputable fact that Jesus walked this earth over 2,000 years ago. We divide human time by his life and his death. This is verified in extrabiblical sources from historians like Josephus, as well as Roman historians like Flavius, Pliny and Tacitus.
If these are lies, then they are the stupidest lies ever concocted, because these accounts were written down during the lifetime of the people who were there.
The Gospels, of course, are also historical documents. In fact, Luke penned the third Gospel as someone who interviewed the people involved in the story. Luke was not one of the original apostles. He investigated the facts and did his report. Luke probably sat down and interviewed Mary, the mother of Jesus. Perhaps he interviewed the shepherds and maybe the wise men. He interviewed the apostles. He got all the details and wrote them down.
That is why the Christmas story does not begin with the words "once upon a time." Rather, it begins, "In those days Caesar Augustus issued a decree that a census should be taken of the entire Roman world. (This was the first census that took place while Quirinius was governor of Syria)" (Luke 2:1-2 NIV).
This pinpoints it in time. We know who Caesar Augustus was and when he lived, so these are specific details given to us in the Scriptures.
"We saw these things," John was saying. "We heard these things, and here's why we wrote it all down: so you could have the same relationship with God." That is really the message of Christmas: God is with us, and God can be known.
Jesus Christ was fully God, and Jesus Christ was fully man. He wasn't a man who became God. That's impossible. He was God who became a man. What could be more human than Jesus falling asleep on the boat as they crossed the Sea of Galilee? And what could be more divine than Jesus, after being awakened by the disciples, rebuking and stopping the storm?
What could be more human than being beaten, having the beard plucked from your face, having nails driven through your hands, and feeling excruciating pain? But what could be more divine than the sky going dark? What could be more divine than the veil in the temple, inches of interwoven material separating the Holy of Holies, being ripped – not from bottom to top but from top to bottom? What could be more divine than the earthquakes that hit when Christ was dying for the sins of the world?
Jesus Christ was fully God and fully man. He was God with skin on.
Jesus became one of us without ceasing to be himself. He became human without ceasing to be God. The Bible tells us that "being found in appearance as a man, he humbled himself by becoming obedient to death – even death on a cross!" (Philippians 2:8 NIV).
He came for all of us. Almighty God, the creator of heaven and earth, left the glories of heaven because he wants a relationship and a friendship with us. God has walked among us, in our shoes, experiencing the challenges and difficulties and problems of life. And the Bible tells us he "has been temed in every way, just as we are – yet he did not sin" (Hebrews 4:15 NIV).
Henry Ford, founder of the Ford Motor Company, had a friend named Charles Steinmetz who was a mechanical genius. One day Ford had a problem that none of his people could fix. So he called for Charles. Charles tinkered for a while, and things ran smoothly once again. Afterward he sent Ford a bill for $10,000.
Henry Ford questioned the amount and requested a new, itemized bill. So Charles sent a revised bill, which read: Tinkering: $10. Knowing where to tinker: $9,990. Charles knew where to tinker.
In the same way, when your life is broken, God knows where to tinker. He knows where the problem is because he has walked among us.


Happy New Year! Wishing you a wonderful, safe and romantic New Year! We just wanted to quickly say how thankful we are to do a job we love immensely. We are humbly thankful to all of the couples that entrusted us this year, all the new friends and colleagues we've met and continuing to have moments that make what we do so worthwhile.
If your holiday season looks very similar to the photo above, call us! We are very excited to get to know you, hear your love story, and see if we're a good fit to help you plan your dream day.
Please mention this blog post and say " Baby It's Cold Outside…" to receive 10% off when you retain our services by January 15th. If you sing it in a Will Ferrell/Elf movie inspired voice, you get another 5% off! Okay, well, that last part was a joke, but we'd love to hear you sing about your winter romance!
Wishing you health, prosperity and love in the new year Cheers to 2013!


If personal computers (PCs) are used to enhance learning and information gathering across a variety of subjects, then a home computer might reasonably be considered an input in an educational production function. Using data on British youths from the British Household Panel Survey between 1991 and 2001, this paper attempts to explore the link between ownership of a home computer at ages 15 and 17 and subsequent educational attainment in the principal British school examinations taken at ages 16 (GCSEs) and 18 (A levels). The data show a significant positive associatio n between PC ownership and both the number of GCSEs obtained and the probability of passing five or more GCSEs. These results survive a set of individual, household, and area controls, including using other household durables and \"future\" PC ownership as proxies for household wealth and other unobservable household level effects. Home computer ownership is also associated with a significant increase in the probability of passing at least one A level conditional on having passed five and increase in the probability of successfully completing three or more A levels, conditional on having passed at least one A level.


text:
irish sea legends
The island is supposed to be located somewhere off the western coast of Ireland and several people have reported either visiting the place or witnessing its appearance and disappearance. This causeway was 'constructed' after Fionn was challenged to a fight by a Scottish giant. But doing so seals your death warrant, as the kelpie will take you for the ride of your life before leaping into its watery home to drown and consume you. In one legend, an Irish man is granted use of the red cap so he can visit a male merrow's home under the sea. Dobhar Chu is said to look like a combination of a wolfhound and a fish, and in fact, its name translates to "water hound." It is extremely fast and agile both in and out of water, always ready to attack the unwary. ( Public Domain ). They share similarities with sirens, mermaids and mermen in other cultures. Climate researchers exploring the molecular-structure of stalagmites discovered in Laos caves have married their observations with models of the Sahara drying up 4,000 years ago to show the... On August 29th 2018 The Smithsonian Institute announced "Climate records gathered from stalagmites in Romanian caves show two extremely cold dry periods correspond with the disappearance of... New Caledonia, in the South Pacific , is a special collectivity of France. This cookie doesn't save any personal Data about any shop client. This story was told to deter small children from going too near the water. Archaeological Mystery: 10,000 or More Caves were Dug into the Himalayas Over 2,000 Years Ago, Sobekneferu's Legacy: The Sacred Places of Egypt's First Female Pharaoh, Ten Stunning Yet Little Known Ancient Treasures Across Africa, Medieval Metallic Objects Show Alchemical Mastery In Poland, Yin Female Taosim In Search Of Immortality, King David Era Fort Discovered in Israel's Golan Heights. lol. Cookie lasts for 30 days. The Nephilim: Giant Offspring of the Sons of God and the Daughters of Man? He missed her very much, but his children kept him company for the rest of his life, except for the nights when their mother's song called them to come to her and swim through the waves. Norimitsu Odachi: Who Could Have Possibly Wielded This Enormous 15th Century Japanese Sword? The second they moved there and were about to go to sleep, the doors were slammed open and they were taunted by Corney, who gleefully informed them he was not confined in any part of the house and could go as he pleased. This took care of the cat—at least, for a few months. Today selkies are used as characters in movies, television shows, and books all over the world. Caves and cave systems have an enduring fascination for us and are to be found all over the world. Another story says that seal people are really Finns that travel in kayaks and wear furs. Irish for "people of the mounds," the Aos Sí are a race of fae folk said to live in the mounds that are common across the Irish countryside. This handsome fella is a type of fairy who appears to women and makes them hopelessly fall in love with him. Its native flora is so rare and unique that the island looks like something out of a science-fiction movie. The Scottish water horse spirit is called the water kelpie. This is only one variation, of course, and thus is contradicted by other mythologies, however it is pertinent to the tale of Selkies because it reveals that all human/Selkie marriages are not hollow. One of the most popular theories is that they were formed from the souls of drowned people who were granted one night each year to return to their human form and dance upon the shore of the sea. According to legend, a particularly notable ghost of the area is Lord Norbury, a ruthless 19th-century judge who was cursed by the widow of one of his victims to forever wander the Jervis area as a large black dog carrying heavy iron chains. An Encyclopedia of Fairies. The Fiji Mermaid: What Was the Abominable Creature and Why Was It So Popular? A lesser known legend of a supernatural sea creature is that of the selkie. The specter is a neatly dressed elderly man with a white beard and all it wants is a quiet pint of Guinness in the corner before disappearing. The landscape of the remote island of Socotra looks so foreign that it could almost pass as an alien planet. Orkneyjar: the heritage of the Orkney Islands. Tales of the seal people: Scottish folk tales. The seal people, once upon the shore, were said to have danced in the moonlight. Though this tale indicates a real love between the Selkie wife and her human husband, her donning of her seal skin will prevent her from ever taking part in the human world again. After Neil had fallen asleep, the selkie woman took her sealskin to the water's edge. Today, there are scientific names for all of the above. At first, Corney sabotaged their attempts to sell the house by speaking to potential purchasers and driving them away, but the lady of the house—the only person Corney seemed to genuinely respect—convinced him to let them move away. Are Fossils Linked to the Legendary Kraken Enough to Prove its Terrifying Existence? Apparently they had been washed up to shore from a bad storm. 1992. A Shop Cookie, which saves data about orders, carts, IP of the clients. There were children sometimes born with webbed fingers and toes, faces resembling that of a seal, and sometimes, scaly skin that smelled fishy. One day, the children came running to her with a piece of fur, excited to show her what they had found. Selkies are predominately mythological creatures from Irish, Scottish (particularly in Orkney and the Shetland Islands) and Faroese folklore, however there is a similar tradition in Iceland as well. Unmasking King Richard I: Does the Lionhearted King of England Have a Better Reputation Than He Deserves? By bringing together top experts and authors, this archaeology website explores lost civilizations, examines sacred writings, tours ancient places, investigates ancient discoveries and questions mysterious happenings. Without fail, though, he will eventually grow tired of his new girlfriend and disappear — but his supernatural hold over her will never go away, and she will be unable to move on for the rest of her life.
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irish sea legends 2020


Prowers Economic Prosperity will host an upcoming Town Hall Meeting on Thursday, July 19, 2018, 6:30 pm at Lamar Community College in the Large Lecture Hall with Colorado State Senator Larry Crowder (Senate District 35) and Colorado State Representative Kimmi Lewis (House District 64).
Residents are invited to join Senator Crowder and Representative Lewis to listen to updates from the most recent legislative session, ask questions and share thoughts on state and local issues. Southeast Colorado residents may want updates on hot topics including transportation, education and rural healthcare, as well as learning more about State regulations relating to the local landfill issues and energy development.
For more information contact Eric Depperschmidt at Prowers Economic Prosperity. He can be contacted at 719-336-2384 or at director@prowerspep.org.
Prowers County Town Hall Meeting – 6:30 p.m.