text:
Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes
Yanisa Mittraphab, Yhiya Amen, Maki Nagata, Masako Matsumoto, Dongmei Wang, Kuniyoshi Shimizu
Sustainable Bioresources Science
The extract from Entada phaseoloides was employed as active ingredients of natural origin into cosmetic products, while the components analysis was barely reported. Using LC-DAD-MS/qTOF analysis, eleven compounds (1–11) were proposed or identified from acetone extract of E. phaseoloides leaves (AE). Among them, six phenolic compounds, protocatechuic acid (2), 4-hydroxybenzoic acid (3), luteolin-7-O-β-d-glucoside (5), cirsimaritin (6), dihydrokaempferol (9), and apigenin (10), were isolated by various chromatographic techniques. Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 μM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene. Moreover, compounds 2 and 4 could have potent effects on cell migration during wound closure. These results suggest that compounds 2, 4, and 11 from AE have anti-photoaging properties and could be employed in pharmaceutical and cosmeceutical products.
https://doi.org/10.3390/molecules27020440
Chemistry (miscellaneous)
10.3390/molecules27020440
Dive into the research topics of 'Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes'. Together they form a unique fingerprint.
Analytical Method Chemistry 100%
Chemical Reaction Product Chemistry 100%
Acetone Chemistry 100%
Acid Chemistry 100%
Phenolic Compound Chemistry 100%
Phenol Pharmacology, Toxicology and Pharmaceutical Science 100%
Protocatechuic Acid Pharmacology, Toxicology and Pharmaceutical Science 100%
Procedure Chemistry 50%
Mittraphab, Y., Amen, Y., Nagata, M., Matsumoto, M., Wang, D., & Shimizu, K. (2022). Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes. Molecules, 27(2), [440]. https://doi.org/10.3390/molecules27020440
Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes. / Mittraphab, Yanisa; Amen, Yhiya; Nagata, Maki et al.
In: Molecules, Vol. 27, No. 2, 440, 01.01.2022.
Mittraphab, Y, Amen, Y, Nagata, M, Matsumoto, M, Wang, D & Shimizu, K 2022, 'Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes', Molecules, vol. 27, no. 2, 440. https://doi.org/10.3390/molecules27020440
Mittraphab Y, Amen Y, Nagata M, Matsumoto M, Wang D, Shimizu K. Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes. Molecules. 2022 Jan 1;27(2):440. doi: 10.3390/molecules27020440
Mittraphab, Yanisa ; Amen, Yhiya ; Nagata, Maki et al. / Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes. In: Molecules. 2022 ; Vol. 27, No. 2.
@article{927f0d1bebf546ad9185a6c286358eb7,
title = "Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes",
abstract = "The extract from Entada phaseoloides was employed as active ingredients of natural origin into cosmetic products, while the components analysis was barely reported. Using LC-DAD-MS/qTOF analysis, eleven compounds (1–11) were proposed or identified from acetone extract of E. phaseoloides leaves (AE). Among them, six phenolic compounds, protocatechuic acid (2), 4-hydroxybenzoic acid (3), luteolin-7-O-β-d-glucoside (5), cirsimaritin (6), dihydrokaempferol (9), and apigenin (10), were isolated by various chromatographic techniques. Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 μM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene. Moreover, compounds 2 and 4 could have potent effects on cell migration during wound closure. These results suggest that compounds 2, 4, and 11 from AE have anti-photoaging properties and could be employed in pharmaceutical and cosmeceutical products.",
author = "Yanisa Mittraphab and Yhiya Amen and Maki Nagata and Masako Matsumoto and Dongmei Wang and Kuniyoshi Shimizu",
note = "Funding Information: Acknowledgments: The first authors are thankful to the Mitsubishi UFJ Trust Scholarship Foundation for a scholarship. Publisher Copyright: {\textcopyright} 2022 by the authors. Licensee MDPI, Basel, Switzerland.",
doi = "10.3390/molecules27020440",
journal = "Molecules",
T1 - Anti-Phototoxicity Effect of Phenolic Compounds from Acetone Extract of Entada phaseoloides Leaves via Activation of COX-2 and iNOS in Human Epidermal Keratinocytes
AU - Mittraphab, Yanisa
AU - Amen, Yhiya
AU - Nagata, Maki
AU - Matsumoto, Masako
AU - Wang, Dongmei
AU - Shimizu, Kuniyoshi
N1 - Funding Information: Acknowledgments: The first authors are thankful to the Mitsubishi UFJ Trust Scholarship Foundation for a scholarship. Publisher Copyright: © 2022 by the authors. Licensee MDPI, Basel, Switzerland.
N2 - The extract from Entada phaseoloides was employed as active ingredients of natural origin into cosmetic products, while the components analysis was barely reported. Using LC-DAD-MS/qTOF analysis, eleven compounds (1–11) were proposed or identified from acetone extract of E. phaseoloides leaves (AE). Among them, six phenolic compounds, protocatechuic acid (2), 4-hydroxybenzoic acid (3), luteolin-7-O-β-d-glucoside (5), cirsimaritin (6), dihydrokaempferol (9), and apigenin (10), were isolated by various chromatographic techniques. Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 μM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene. Moreover, compounds 2 and 4 could have potent effects on cell migration during wound closure. These results suggest that compounds 2, 4, and 11 from AE have anti-photoaging properties and could be employed in pharmaceutical and cosmeceutical products.
AB - The extract from Entada phaseoloides was employed as active ingredients of natural origin into cosmetic products, while the components analysis was barely reported. Using LC-DAD-MS/qTOF analysis, eleven compounds (1–11) were proposed or identified from acetone extract of E. phaseoloides leaves (AE). Among them, six phenolic compounds, protocatechuic acid (2), 4-hydroxybenzoic acid (3), luteolin-7-O-β-d-glucoside (5), cirsimaritin (6), dihydrokaempferol (9), and apigenin (10), were isolated by various chromatographic techniques. Protocatechuic acid (2), epicatechin (4), and kaempferol (11) at a concentration 100 μM increased the HaCaT cells viability of the UVB-irradiated cell without any cytotoxicity effect and reduced the expression of COX-2 and iNOS inflammation gene. Moreover, compounds 2 and 4 could have potent effects on cell migration during wound closure. These results suggest that compounds 2, 4, and 11 from AE have anti-photoaging properties and could be employed in pharmaceutical and cosmeceutical products.
U2 - 10.3390/molecules27020440
DO - 10.3390/molecules27020440
JO - Molecules
JF - Molecules


text:
Advising Appointments
Keyword Search of histart
History of Art Major
Helicon Undergraduate Student Group
History of Art Minor
History of Art Honors Program
Arts in Paris Summer Program
Museum Studies Minor
Career Guide and Resources
Waitlist Policy
Certificate in Museum Studies
Dissertation Titles
Alumni Video
Neo-avant-garde and Postmodern: Postwar Architecture in Britain and Beyond
Lecturers and Visitors
Claire Zimmerman
The neo-avant-garde and postmodern movements have long been understood in terms of their re-working of modernism and a narrative emphasizing rupture and new beginnings. Compelling continuities between the two, especially in postwar Britain, suggest that a new account is needed. This collection of provocative essays discusses the work of architects and their associates, including Alice and Peter Smithson, Robert Venturi and Denise Scott Brown, James Stirling, James Gowan, Eduardo Paolozzi, Leon Krier, Allan Greenberg, Reyner Banham, and Charles Jencks, and explores why the debate over postwar modernism was especially vocal in Britain. Essays by sixteen distinguished scholars examine such topics as Brutalism, pop architecture, 1950s London, the legacy of Mies van der Rohe, housing, civic architecture, Italian neo-realism, and changing alignments in theory and philosophy of the period. While the essays focus on Britain, they also look beyond to Brazil, New Zealand, and the United States, expanding the discussion to include new kinds of internationalization that developed rapidly in the postwar period and set the stage for architectural developments today. Publisher: Yale University Press Month of Publication: January Year of Publication: 2011 # of Pages: 432 ISBN: 978-0300166187
Tappan Hall
855 South University Avenue
histartadmiss@umich.edu

redpajama_set_name: RedPajamaCommonCrawl


Castlrea Garda are currently investigating an incident in which a woman was dragged from her car, and assaulted on the Tulsk to Elphin Road, Co Roscommon last week.
It is understood a woman was driving on the road last Tuesday evening, June 26. She overtook a car and stopped after the car behind flashed its lights.
The driver of the car approached shouting, dragged the woman from her car and hit her in an unprovoked attack. The woman has identified the registration number of the car.
They are appealing for any witnesses who may have seen the incident to contact Castlerea Garda Station on (094) 962 0019.


text:
Beyond the World
Fastaval, Mark Rein-Hagen, Bona the Robot!
April 14, 2014 at 9:55 am	(Uncategorized) (age of the tempest, crowdfunding, denmark, event, fastaval, heroes of the storm, mark rein-hagen, myrskyn sankarit, rpg, scifi, simon stålenhag, society for nordic roleplaying, travel)
I'm going to spend Easter at the legendary Danish gaming convention Fastaval. (This is my first time, so forgive me, if I'm off on some details.)
Unelma keltaisesta kuninkaasta.
Fastaval is not your average convention — it specializes in incredibly tight auteur-designed roleplaying scenarios. A bunch of people run each scenario for players, not just the creator. There's awards for best scenarios in different categories.
The Society for Nordic Roleplaying published a collection of these scenarios translated into Finnish a few years ago, called Unelma keltaisesta kuninkaasta ja muita tanskalaisia roolipelejä (A Dream of a King in Yellow, and other Danish roleplaying games. Edited by Kristoffer Apollo, Juhana Pettersson and Tobias Wrigstad).
Because it's my first time at Fastaval, I want to get as much out of it as possible. I didn't have time to offer my own scenario to be run there, but I will be running the scenario Stories from Bona: The Robot by Jesper Bisgaard, René Toft and Ulrik Høyer Kold. It is atmospheric sci-fi, inspired by Swedish artist Simon Stålenhag's images with automated agricultural machinery, giant satellites and rusty robot wrecks scattered in the Swedish wilderness.
In Stories From Bona: The Robot you play four children living in central Sweden backwater that take a stand against superior forces and lose. The scenario is melancholy rural science fiction for those who go back when they think about the future. It is quiet counterfactual social realism in large landscapes.
Simon Stålenhag: Decoy.
I'll also be chatting with legendary Vampire: The Masquerade creator Mark Rein-Hagen about role-playing games, crowdfunding, and other interesting stuff. That's at 16:15 on Saturday!
Special guest talk: Q and A with Mark Rein-Hagen and Mike Pohjola
Crowdfunding your game – How and why?
In the last few years published RPGs, card games and board games have discovered a new form of financing: crowdfunding. It allows designers to bypass the traditional channels of publishers, distributors and retailers and go straight to the gamers who get to vote with their wallets.Fastaval guest of honor Mark Rein-Hagen (Democracy Card Game and I Am Zombie) and Finnish rpg designer Mike Pohjola (Age of the Tempest) discuss their crowdfunded games, the how-tos and no-gos when funding games on Kickstarter, Indiegogo and alike. Audience participation welcome.
I'll also have some special announcements about my beginner-friendly role-playing game Myrskyn sankarit (Age of the Tempest), and I'll carry around an ultra-rare copy of the English translation. It's not for sale yet, but feel free to check it out if you're around!
Permalink Leave a Comment
Blockistan the Duplo blog
December 10, 2012 at 3:22 pm	(Uncategorized)
My 2,5-year old son and I have a Duplo blog called Blockistan. It's proven a fun way of being together, even if he hasn't yet fully grasped the social media aspect…
I just updated the blog with new fun stuff, including pentagons, hexagons, The Simpsons, and Duplo snowflakes! Check it out!
Interviewed in a Croatian blog
December 7, 2012 at 1:50 pm	(Uncategorized) (blog, croatia, diary of a croatian larper, georgia, interview, larp girl, manifesto, media, turku, us)
I was interviewed in the blog Diary of a Croatian Larper. Read the article here.
An even bigger honor was bestowed upon me a few weeks ago. I read on the same site an interview of the American "Larp Girl", Kaza Marie Ayersman,who talked about her own live roleplaying community in the state of Georgia. Apparently the Manifesto of the Turku School has completely changed their fantasy larp campaign, when the group ran into it some years back. Quite amazing, considering the manifesto is almost thirteen years old!
There's other good stuff in the blog, too. Definitely worth checking out!
Permalink 1 Comment
Thank you Steam!
October 4, 2012 at 7:42 am	(Uncategorized) (civilization, customer support, ftl, game, internet, marketplace, online, software, steam, valve)
I installed Steam on my MacBook a few weeks ago to try a game called FTL that everyone seemed to recommend. In case you don't know, Steam is a digital game distribution platform by Valve, the creators of Half-Life and numerous other games. For the purposes of this blog entry, think of it as an online game store.
I liked FTL and was browsing for other Mac games when I ran across Civilization V. I've played all the other games in the series, so I decided to pay the €29.99 ($39) to download this one, too. I knew it would keep me playing for years, so it seemed like a reasonable investment.
But, as happens increasingly often these days, the game wouldn't launch on my Mac. Many Apple products (even simple ones like iCal) refuse to work on OS X 10.5.8, but require OS X 10.6 which would also mean getting a new computer. An evil plot by Apple, but fortunately not shared in by many other companies.
I was very frustrated, but decided to write to Steam Support just for the hell of it. Maybe that way I'd at least feel like I'd done something instead of just fretting over the matter by myself. Here's my letter to them on Sunday.
I'm new to Steam, and just bought Civilization V since I noticed it's available for Mac. However, upon launching it, I just get an error message saying "You cannot use this version of the application Civilization V with this version of Mac OS X."
Apparently Civ V isn't intended for Macs that have a PowerPC processor, which is getting more and more common these days. (And more and more frustrating for those of us who have a relatively new PowerPC Mac…)
I'm wondering what I should do to return the game, since it turns out I can't play it with my computer after all.
Other than this problem, Steam seems to work great, and I'm really excited to use it more!
Thanks a million for getting back to me!
Mike Pohjola
I knew I was tilting at windmills here, with no real chance of getting my money back. I was fully prepared for yet another disappointment in the world of online transactions. In a way, I was just letting off some, if you'll pardon the pun, steam.
Great was my surprise and delight, when not two days after my letter, I got this reply from Steam Support:
Thank you for contacting Steam Support.
As requested, we have processed a refund to your account.
Your bank or credit card issuer will return the funds to your account – please allow 3-5 business days for the funds to be posted.
Please note in the future that Steam purchases, per the Steam Subscriber Agreement, are not refundable – this refund was issued as a one-time customer service gesture.
Steam Subscriber Agreement
http://www.steampowered.com/index.php?area=subscriber_agreement
If you require any further assistance, please let us know.
Thank you Steam! This gesture certainly made one customer very happy and will ensure I'll do all my business with you in the future. (And spend much more than the original thirty Euros.) Furthermore, I ask everyone to share this update to get more good will for such business practices and customer treatment.
Well played, Steam and Valve!
Also, here's links to the pretty great scifi game FTL and Civilization V (in case you can run it) on Steam.
(This blog entry is CC BY SA.)
Musings on genre
September 6, 2012 at 7:00 am	(Uncategorized) (books, fantasy, genre, heavy metal, hiphop, literature, techno)
Earlier, whenever I'd hear a techno song or a hiphop song, my initial thoughts used to be along the lines: "But these all sound exactly the same." Many otherwise sensible people have the same reaction to metal music. I've come to think this is the same as saying: "I'm not familiar with this type of music." (So I'm trying to stop saying it.)
Now, if we can agree to that, does the same apply for genre literature, as well? Quite often you hear people complaining the fantasy novels are all the same. You know, good guys, bad guys, dragons, knights, swords, elves, wizards etc etc. On one hand, it's true, many of them use the same elements. On the other hand, if you don't have any of them, it just doesn't feel like fantasy anymore. One can use these elements in a cliched manner or in a new, original way, so it's not the elements themselves that proclaim a work cliched or not. So, when someone not that much into fantasy complains that all fantasy books are the same, what they mean is "I'm not familiar with this type of literature."
The same goes for detective novels, sci-fi, romance novels, and pretty much any genre out there. So we should stop complaining how "These books are all the same."
I propose a Baltic Union in a German newspaper
August 29, 2012 at 9:37 am	(Uncategorized) (angela merkel, economics, euro crisis, european union, finland, jutta urpilainen, politics, timo soini)
I was interviewed in Frankfurter Allgemeine Zeitung about the Euro Crisis. They chose one writer from each Euro country to comment on the matter. Here's my part as a PDF. (The three other parts of the series will be published in later issues.)
They made the interview during the Olympic Games so the thoughts on the Baltic Union are not a cry of support for our populist political leader Timo Soini who has since voiced similar thoughts. My German isn't good enough to tell whether it's clear that this is an idea for a culturally and historically more connected union, not a demand based on real politics.
Here's some parts of the interview that was originally conducted in English:
I believe the Lehman Brothers collapse and the current Euro crisis are but symptoms of the wider problems in our economic system. After the collapse of the Soviet Union, the 90's and the 2000's saw a huge deregulation of banks and markets, undemocratization of governments and market-driven globalization. This allowed for commercial banks and investment banks to fuse into huge banking conglomerates which are too big to fail. When governments base all their decisions on what's good for the economy, this means that in fact it's the banks that are in charge, not governments.
One starting point for the crisis was in 2005, when Germany and France pushed the EU to adopt the Basel II recommendations, tying European banks' and even the European Central Bank's credit rating systems to the American credit rating cartel of Moody's and S&P. At least in Finland it seems the question "Will this affect our influence in the EU?" has changed to "Will this affect our credit rating?". Finnish media and politicians take an unhealthy pride in having AAA rating and look down on the countries who score worse. Having a private credit rating cartel dictate European economic policies is a bit like having a doping manufacturer decide on how to check the Olympic athletes for illegal substances.
The criticism against EU and the Euro has always been vocal, but it seems to gain new momentum now. So far it's been mostly the conservatives and the nationalists who are against the monetary union, but now there's also lots of doubts from the left and the right. The current coalition government consists of capitalists, socialists, social democrats, greens, Christians and the Swedish language party, and even though they're officially for supporting Spain, their ranks seem to be falling apart.
The most common public opinion is that there are great problems with the Euro, because the "southern" countries have wide-spread corruption and even that the southern people are lazy. It's seen as unfair that the honest, hard-working northerners like Finns and Germans have to carry more than their rightful share. This just goes to show how people in a complex situation are desperately looking for easy answers and guilty parties.
First of all, Germany has a much larger vested interest in the well-being of Spanish banks, since many of those banks are credited by German and French banks. From an economic perspective, it makes perfect sense for Germany to want to bail out their own banks. For Finns, the question is much more complicated, and mostly based on the idea that if the Euro fails, it will probably somehow negatively affect Finns, as well, maybe.
Also, at least according to the newspapers, Merkel's government hasn't had such an easy time in getting the Germans or even the Bundestag to approve bailing out banks with tax money, either.
Another factor is Finland's very complex government coalition. When the government was formed a year ago, the large Social Democrat Party and the mid-sized Left Alliance were needed to make up a majority in the parliament. But they wouldn't join the right-of-center National Coalition Party -lead government unless everyone agreed they would make the shareholders of the bailed-out banks responsible, as well. I think this was a good idea, since otherwise the shareholders would have made lots of profit without sharing none of the risks. In practice this has been problematic, as it means Finland has to go through special negotiations with each bailed-out country, and after the negotiations all the other countries might feel like they're been cheated, if they don't have a chance to get the same benefits as Finland has.
However, our (Social Democrat) Finance Minister Jutta Urpilainen has a very strong position at the moment, since she has just successfully negotiated the Spanish bail-out agreement, which seemed very unlikely at the time.
Whenever someone says there is no alternative, I become sceptical. Both Finnish and German governments have been very adamant in this policy of no alternatives, which for means that there is something for someone to gain by saying this. It's possible they really do believe that one more bankrupt bank would result in a total chaos and a new Great Depression. But it's equally likely that they are so closely connected to the banks that they have no choice except bail them out over and over again. It's also possible that the situation is so complex even the politicians have no idea what would happen, and have chosen to avoid all risks, even though the bill seems to be quite high.
One thing I'm certainly glad the Bundestag did, is not allow the money to go to Spanish banks directly. Giving it to either the Spanish governments for them to help the banks, or having ECB control the bank regulation first seems like a step in the right direction.
I don't know if "the idea of Europe" ever really did exist. I remember in the 90s when the European Community and European Union were advertized as carrying on the great Greek traditions of democracy and equality and so forth. All the brochures and early websites were full of pictures of Athenian temples and Olympian gods. In a way, the idea of Europe was suddenly and artificially created on top of Greek antiquity. And now there's talk of throwing Greece out of the Union entirely.
So if we're not building Europe on the traditions of ancient Greece, what are we building it on? There certainly have been movements and empires that have spanned large parts of Europe, but none that would even closely resemble the European Union. We've had the Roman Empire, the two Catholic Churches, the Ottoman Empire, the Renaissance, the Reformation, the Enlightenment, Napoleon's Empire, and lots and lots of wars. Previously we were part of the West heroically standing against the Soviet Bloc, and now suddenly that Bloc makes up half of the Union. We're a continent split apart religiously, politically, ethnically, linguistically, culturally, and don't really have much in common, apart from the Euro.
If you want to talk about ideas, I think a Mediterranean Union and a Baltic Union would make much more sense, even though they're tied together by sea instead of land. The Mediterranean Union would carry on the ideas of Greece/Roman classicism, the Catholic Churches, the Ottoman Empire and the Roman Empire. The Mediterranean Union could consist of Spain, France, Italy, Greece, Turkey, and possibly Northern African and Middle Eastern democracies. Austria, former Yugoslavia, the Ukraine, Bulgaria, and such countries might also be members. The Roman languages and Arabic would be the common languages.
The Baltic Union would be based around the tradition of the Hanseatic League, Protestantism, Norse and Slavic paganism, Secularism and the German, Danish, Russian and Swedish Empires. The member states of the Baltic Union would be all the Nordic, Baltic and Benelux countries, Poland, Germany, Czech, Russia and the UK. The common languages would be German, English and Russian.
Central European states would be welcome to join in, possibly some would want to split two ways.
The birth of the EU was in preventing yet another great war in Europe. I agree this is a lofty goal, and these two unions might easily fall into feuding. Strong economic and political ties would ensure this doesn't happen.
Crowdfunding a roleplaying game for kids
August 11, 2012 at 12:49 pm	(Uncategorized) (crowdfunding, dragonbane, finland, games, heroes of storm, king arthur, knights of the round table, larp, myrskyn sankarit, publicity, robin hood, rpg, star wars, writing)
I'm making an entry-level tabletop roleplaying game for kids. I started playing the D&D Red Box when I was 9, and so did pretty much everyone else in my generation. There hasn't really been anything like that available in Finland, and from what I can tell, not really anywhere. (If there is, please correct me, but definitely nothing over here.)
Therefore I hope to publish a tabletop roleplaying game for kids 9-13 years old, and I'm raising money for it. Myrskyn sankarit ("Heroes of Storm") is based on my earlier tabletop RPG, Myrskyn aika ("Age of Storm") that was also the setting for the larp Dragonbane. Here's the crowdfunding site: http://www.indiegogo.com/myrskynsankarit
The story is about a group of brave rebels who live in the forest and fight against an evil witch emperor, in the vein of Robin Hood, Star Wars and Knights of the Round Table. And yes, it will have lots of strong female characters, as well!
The initial version will be published in Finnish, but while I'm at it, why not aim for a bigger thing.
If I raise enough cash (and I think I will), I can publish this in Finnish. Hopefully we'll get some supermarket distribution, but at least it'll be available in all the gaming stores and the like. Now, after that, the translation into English won't be too big a hassle. (I already have people to do that.)
But for all this to work, I need money NOW to pay for the printing, storage, postage, marketing and so on. I've just added a special international friendly "Khaleesi Daenerys Targaryen" Perk for $75 that will get you a copy of the Finnish language box, a PDF of the English translation (if we get to that), and eventually a boxed copy in English or whatever your chosen language is (if we get to that). If the project doesn't reach its funding, you won't pay anything,
Here are the other Perks in English, in case you want to invest more!
We've already raised almost half of the money (in less than a third of the time), have 350 Facebook supporters, and yesterday the crowdfunding site IndieGoGo.com decided to honor us by having Myrskyn sankarit as one of the featured projects on their homepage! Please participate, and help spread the word!
http://www.indiegogo.com/myrskynsankarit
July 4, 2012 at 2:55 pm	(Uncategorized) (adventure, i hate myself for what i must do, james d. raggi iv, joel sammallahti, lamentations of the flame princess, rpg)
I'm designing an adventure for the Lamentations of the Flame Princess roleplaying game, and need funding! The author of the game is a Finnish-based American, James D. Raggi IV, and he has about a dozen simultaneous crowdfunding campaigns going on. (There's some other cool ones, as well, you can see them on the same page.)
I Hate Myself For What I Must Do is an exciting, maybe even provoking, weird fantasy heavy metal adventure, illustrated by the amazing Joel Sammallahti. The adventure will be made, if we reach the $6000 budget. (But if we don't, you won't lose anything.) You can participate here! (You'll also be helping me get more intimate with the mysteries of crowdfunding for a big project I'll launch later this month…)
Lamentations of the Flame Princess presents I Hate Myself for What I Must Do by Mike Pohjola, illustrated by Joel Sammallahti
A village tormented by a blasphemous priest.
A vile daemon summoned upon the world.
A curse which cannot be lifted.
At dusk you still considered yourself one of the good guys. Hardly perfect, but you tried to do the right thing. But now it seems the right thing is the wrong thing, and before sunrise you must become as despicable a person as possible.
You hate yourself for doing all this. But you have no choice. Or so you keep telling yourself. Your noble end justifies whatever horrible means you must take.
I Hate Myself For What I Must Do is a Lamentations of the Flame Princess weird fantasy heavy metal adventure by Mike Pohjola.
Iron Sky grudgingly featured at the Midnight Sun Film Festival
June 15, 2012 at 6:20 am	(Uncategorized) (aki kaurismäki, harriet andersson, ingmar bergman, iron sky, midnight sun film festival, peter von bagh, sodankylä)
I'm in Sodankylä at the Midnight Sun Film Festival, the only place where the Finnish cultural elite can be seen wearing rubber boots and rain coats. The programme (curated by Peter von Bagh) contains mostly of black and white art films nobody's ever heard of. (And silent classics, of course.)
Even though I'm dissing the festival in this post, let me first say I love it! It's a chance to see brilliant movies on actual film copies surrounded by hardcore movie buffs who've bothered to travel to Lapland just for this. When you're watching a movie with some great actor you may soon notice that great actor is sitting next to you. You may end up dancing with legendary producers or standing in pancake line in the middle of the night with your favorite director. It's a very democratic event in that sense, and full of great movies and conversations and lit by the wonderful midnight sun that one can only experience north of the Arctic Circle.
That said, they're also very elitist about the films themselves. If they got to choose, the only Finnish films they'd show would be those by Aki Kaurismäki. But for some reason (I assume it has to do with grants), they also show all the Finnish feature-length fictions of the previous year. Which this time includes Iron Sky.
And boy, do they hate it!
In film festival catalogs, writers quickly learn how to praise even bad films so that they sound good. (And readers quickly learn how to interpret those texts.) For example, a film with an incomprehensible plot and shaky camerawork can be dreamlike and premiering bold visual techniques. Not exactly lying, just obfuscating the problems.
Even if you hated Iron Sky, you could easily say it has amazing visuals and lots of film references and that it's a future cult classic, and the whole approach is fresh and interesting. But no! This is the most passive aggressive text I've ever seen in a film festival catalog.
Iron Sky is an interesting experiment. It has been marketed as a collective screenplay by the Facebook and Twitter generation. The plot was developed openly in virtual reality and anyone could influence it. Thus the digital and sci-fi film about Moon Nazis has been equipped with more or less successful jokes about Nazis.
The technology works and the action scenes are set up with a rumble familiar from the world of computer games. Nazi ideology, hostile to mankind, is condemned in passing.
Iron Sky fits those who are like a child at heart, and able to tell apart black from white, a good person from a bad one. It is also suitable for the devotees of the German language, sci-fi and metal music. The most impressive piece of acting is pulled off by Stephanie Paul playing the female President of the United States. The ghost of Sarah Palin haunts in the background…
The cinematic loan is a genuine clip from The Great Dictator: playing with a globe, Charles Chaplin / Hitler also reminds us of Nazism's horrible past. (PS)
I think the editors must've removed all the swearwords from that description, because it sounds more like an angry rant than a description of a film. Not to mention how it makes little sense and has only a passing relationship to the truth of how this film was made.
When are they showing it? Oh, at 3:30am Saturday night, of course, to make sure even those who'd still want to watch the movie having read that, would have as little chance as possible of doing it.
Anyway, I'm off to hear Peter von Bagh interview Harriet Andersson for two hours. She was the star of many of Ingmar Bergman's films (and his mistress of several years, which somehow always gets mentioned, as if that were one of her greatest achievements). I hope she doesn't make the mistake of saying she liked Iron Sky…
Here's the text: http://www.msfilmfestival.fi/index.php/en/guests-and-programme/films/140-new-finnish-films/280-iron-sky
And the same in Finnish: http://www.msfilmfestival.fi/index.php/fi-FI/vieraat-ja-ohjelmisto/elokuvat/128-uusia-suomalaisia-elokuvia/182-iron-sky
Permalink 6 Comments
Turku Manifesto in Polish
April 24, 2012 at 12:37 pm	(Uncategorized) (conspiracy for good, copernicon, games, larp, manifesto, poland, rpg, torun, travel, turku)
The Manifesto of the Turku School has been published in Polish as Manifest Szkoły Turku! The translator Oskar Mieczkowski was my host at Copernicon in Torun where I was the Guest of Honor last year. If you can read Polish, check it out here. Or read the Vow of Chastity here, and follow the comments, too.
Po tym, co do tej pory zostało tu napisane, łatwo domyślić się jakie są wzajemne stosunki pomiędzy Szkołą Turku a innymi szkołami myślenia o RPG – czyli pomiędzy Turkuistami a gamistami i dramaturgistami. Szkoła Turku walczy o bezpośrednie, ale też długofalowe cele eläytyjistów (immersjonistów) i symulacjonistów.
The English version and all the other Turku School texts are available here. The Manifesto has also been translated into French, Slovak, Russian and Italian.
The Manifesto of the Turku School is a roleplay-related controversial art essay focusing on character immersion.
Resumé: Mike Pohjola
Gino on The Turku Manifesto turns…
bowleshallalumni.org on Heaven and Helsinki 2018 is…
Valencia on Heaven and Helsinki 2018 is…
Alla scoperta della… on Interviewed in a Croatian…
Artur Schönhütte on I propose a Baltic Union in a…
1827 - Infernal Musical aristotle award blackwell briggs blog books business conspiracy for good crowdfunding denmark dollplay event facebook fantasy film finland flag burners games harry potter heavy metal hollywood i'm not a member imnotamember interactive internet itras by jeepform jesus juhana pettersson klingons knudepunkt larp london manifesto marika media music musical myrskyn sankarit nietzsche nokia norway participation pohjola-filmi politics premiere publicity research rituals romantic documentary ropecon rpg science scifi shakespeare solmukohta son of man star wreck states of play sweden teva theatre the company p the forest of babel tim kring travel turku tv twitter tähti täällä kirjokannen alla video writing www zambia
Älymystö blog
blog.starwreck.com
Burger's Designer's Notes
Juhana Pettersson: log
Ms Mandu
Musta tuntuu
Nigerian Prince
Nordic Scene
Reading Deleuze at Airports
Stuff Geeks Love
The company P
Wil Wheaton in Exile


This is a comprehensive list of all Inpatient Rehab services in Concord CA.
Click on any listing to get detailed information about that Concord California Inpatient Drug Rehab.
Inpatient Rehab Concord California - Substance abuse treatment, Detoxification, Halfway house for Inpatient Treatment.
Inpatient Rehab Concord California - Drug Rehab, Alcohol Treatment, Inpatient Drug Rehab, OutPatient, Substance Abuse Treatment, and Residential Treatment for Inpatient Treatment.


Today, Amazon has discounted the Ultimate Ears BOOM 2 Bluetooth Speaker (the Limited Edition models only), to $74.99. That's good for more than half off of its regular price, in fact the regular version is currently selling for $149. Which makes this a really good deal on a great Bluetooth speaker, and it also includes a pretty cool paint job.
The Limited Edition version of the BOOM 2 is basically sporting a new paint job. There are a few versions here, including an "Origami" color that looks really nice, instead of being just a solid color on the Bluetooth speaker. The Ultimate Ears BOOM 2 is a 360-degree speaker, that will easily fill a room with sound and really make a party pretty exciting. The BOOM 2 is able to get plenty loud, which is great because it is also waterproof, so it can be used outside without much of an issue, which is definitely a good thing. Ultimate Ears touts that you can get around 10 to 12 hours of playback on the BOOM 2, which is pretty good, especially for something of this size and this quality of audio. The BOOM 2 does technically support Alexa, but that is through Bluetooth from the smartphone that is connected to it. So it's not quite the same as what the BLAST speakers from Ultimate Ears offers, but pretty similar.


text:
US capture Walker Cup
Last updated at 10:33 15 August 2005
Great Britain & Ireland's recent dominance of the Walker Cup came to an end as Garth McGimpsey's side were pipped to victory by the United States in a dramatic conclusion at Chicago Golf Club.
The visitors, aiming for a fourth successive cup win, were edged out 12 ½ - 11 ½ as the US won the biennial contest for the first time since 1997.
On a day of huge tension, the match was still in the balance as the final tie of the competition between Welshman Nigel Edwards and American Jeff Overton drove off down the 18th fairway.
Edwards, who holed the putt that secured victory for Great Britain & Ireland in the 2003 contest at Ganton, was one down coming down the last and needed to half his match for the holders to retain the trophy.
But when his approach to the green landed 25 feet from the pin, the Welshman could only muster a par and Overton held on for a one hole victory which clinched the point the US needed for overall success.


Cash Depot Philadelphia Pa - Payday loan Online with fast approval. Get Cash Now!
Finding for Cash Depot Philadelphia Pa Obtain $1000 Cash in Quick Time. No Credit rating Needed. Quick Endorsement. Apply online now.
Our own internet site manufactured by skilled web-site developers and most of us positioned these people tasks to increase safety associated with data. Along with the data from application certainly not advances or perhaps redistributes to the finally folks. Might be our companies may make your position from the hard minute. therefore all of us will try and increase services by making use of brand-new characteristics in your case. Perhaps understand what have dollars, you are able to rely on you. All of us present you with mortgage until salaryday within funds. Our mortgage loan service will be EASY along with QUICKLY!!!
Cash Depot Philadelphia Pa, $200-$1000 Payday cash advances within Quickly Occasion. Zero Papers Hassles. Fast Accepted within a few minutes. Obtain On the web Currently.
Cash Depot Payday Loans 90% of our existing customers think payday loans is a great way to obtain cash quickly. Money is one of important factors for living. In daily life, you have to use money for purchasing many things you want. You may pay for present for your spouse in special occasion. You may pay for new electric equipment in your house. We think your friend cannot support you in every case. So, how should you do? Cash Depot Philadelphia Pa	Payday Loan is the best option for you.
From Cash Depot Philadelphia Pa, you can get a lot of benefits.
Why Cash Depot Philadelphia Pa ? That's easy.
Start to GET STARTED NOW.Cash Depot Philadelphia Pa Payday Loan completely online !
Cash Depot Philadelphia Pa – Up to $1000 Payday cash loans. No Fax needed Essential. 24/7 Instantaneous Authorization. Quick Income Today.


text:
Emergency Department Experiencing High Volumes
Code Orange at Thunder Bay Regional Health Sciences Centre
Hospital's President and CEO and CEO of the Health Research Institute Announces Planned Retirement
Thunder Bay Regional Health Sciences Centre receives National Recognition for Meritorious Outcomes from the American College of Surgeons
Thunder Bay Regional Health Sciences Centre among the Most Improved Renal Programs in Ontario
Our Hearts At Home Cardiovascular Campaign Launches
Breast cancer has one of the highest survival rates of all cancer types in Ontario
Sharing and Caring Together: Hospital Celebrates 10 Successful Years of Patient and Family Centred Care
Same place, new test: The fecal immunochemical test (FIT) is now available in Ontario
Specialty Pharmacy Services Provide Better Care for Patients
Check out more Media Releases
Go Back to Media Releases Listing
Need for Retinal Imaging Camera Inspires Community to Give
by Heather Vita November 1, 2016
The Lions Vision Care Centre at the Thunder Bay Regional Health Sciences Centre is in need of a Retinal Imaging Camera; a specialized piece of equipment that allows ophthalmologists to properly see and monitor damage to retinas, caused by a variety of medical conditions, including diabetes. Today the Lions Club announced donations totaling $20,500 toward the camera. They are asking others to join them in making a gift. Pictured here (left to right) are: Dawn MacDonald, Manager, Ambulatory Care at Thunder Bay Regional Health Sciences Centre, Dr. Leland Dhurjon, Ophthalmologist, Lions Vision Care Centre at Thunder Bay Regional Health Sciences Centre, Fin Sellick, a patient at the Lions Vision Care Centre and donor (with husband Bert) to the Camera, Angela Sharbot, Advisory Board Chair, Lions Vision Care Centre and Jody Nesti, Chair, Board of Directors, Thunder Bay Regional Health Sciences Foundation.
The need for new medical equipment at the Thunder Bay Regional Health Sciences Centre is constant, and it is thanks to donors that we're able to provide the critical pieces needed for world-class healthcare.
Currently the Lions Vision Care Centre at the Thunder Bay Regional Health Sciences Centre is in need of a Retinal Imaging Camera; a specialized piece of equipment that allows ophthalmologists to properly see and monitor damage to retinas, caused by a variety of medical conditions, including diabetes. This Camera comes at a cost of $120,000.
The Lions Clubs have always been very supportive of ophthalmology needs at the Health Sciences Centre, having already given $775,056 since 1998. Today, they announced gifts totaling $20,500 to the Retinal Imaging Camera (from the Dryden Lions Club, the Thunder Bay Metro Lions and the Lions Eye Bank of Manitoba and Northwestern Ontario) and hope their gifts will inspire others in our community to make a gift themselves. Already inspired and joining the Lions in their generosity are the Royal Canadian Legion – Fort William Polish Veterans Branch 149 and the Royal Canadian Legion – Slovak Branch 129; each of whom made a gift of $2,500 to the Camera.
"As Lions, we were challenged by Helen Keller to be the 'Knights of the Blind' and our ongoing fundraising and support for the Lions Vision Care Centre is one way we are serving our community in that capacity," said Angela Sharbot, Advisory Board Chair, Lions Vision Care Centre. "I'm proud we've been able to garner support from multiple Lions Clubs for this project and that other groups, including the Royal Canadian Legion Branches, have also taken it upon themselves to make gifts, and for that I'm very thankful."
"There is a significant need in our community for eyecare and I'm very grateful that the Lions Clubs and Royal Canadian Legion Branches have provided such leadership in funding the equipment we require to take care of thousands of patients each year," said Dr. Leland Dhurjon, Ophthalmologist, Lions Vision Care Centre at Thunder Bay Regional Health Sciences Centre. "With this new Camera, I'll be able to view almost double the area of the retina that can be viewed with our current camera. This new treatment will also require no dilation, contact lenses or pressure on the eye."
Dawn MacDonald, Manager, Ambulatory Care at Thunder Bay Regional Health Sciences Centre stressed the importance of the new Retinal Imaging Camera to the Lions Vision Care Centre. "Currently, patients requiring the type of imaging provided by this Camera have to travel to Southern Ontario or Winnipeg, often making the trip every 6 months for ongoing diagnostic and monitoring of their eye condition. So we are aiming for less travel, more comfort, and shorter visits, while providing quality evidence-based care; all a win-win situation."
Fin Sellick, a patient at the Lions Vision Care Centre remarked, "I have received excellent professional eye-care at the Lions Vision Care Centre here in our local hospital, and am grateful that this service is available for individuals here and in Thunder Bay and Northwestern Ontario. It eliminates the high costs of travelling to Toronto for treatment. My husband Burt and I are pleased to support the Fundraising Campaign for the Retinal Imaging Camera for use in our Regional Hospital."
"The long-standing commitment from the Lions Clubs to this cause is remarkable," said Jody Nesti, Chair, Board of Directors, Thunder Bay Regional Health Sciences Foundation. "They show true leadership and vision in giving for the needed equipment at the Lions Vision Care Centre. The additional gifts from the Royal Canadian Legion Branches, as well as the Sellicks, are a wonderful example of the giving nature of our community. I urge those who have yet to make a gift to this new Camera to do so right away. You may have already received a letter in the mail with a story from Dr. Dhurjon; please take the time to read it and make your own gift. Together, we can give the gift of sight."
Gifts can be made:
Online: www.healthsciencesfoundation.ca/vision
By mail: c/o Thunder Bay Regional Health Sciences Foundation, 980 Oliver Rd. Thunder Bay, ON P7B 6V4
In Person: At the Donation Centre inside the Thunder Bay Regional Health Sciences Centre
Heather Vita
Manager, Marketing & Communications
Thunder Bay Regional Health Sciences Foundation
heather.vita@healthsciencesfoundation.ca
HealthSciencesFoundation.ca


4 drawer dresser chest bedroom furniture black brown white, top 20 wooden file cabinets with drawers, christow 6 drawer chest oak effect available at this is. Ameriwood 2 drawer file cabinet, multiple finishes. A chest drawer is also known as a dresser homedeecom.


Dr. Ryan Woods is a non-operative sports medicine physician specializing in regenerative medicine treatments, also known as orthobiologics, which help ease pain and improve function for people with acute and chronic orthopedic conditions, primarily arthritis in the joints. Those treatments include platelet-rich plasma (PRP) and bone marrow aspirate concentrate (BMAC). He also specializes in ultrasound-guided care, including MSK (musculoskeletal) ultrasound. Dr. Woods joined BayCare Clinic in 2018. He was fellowship trained in physical medicine and rehabilitation sports medicine at the Mayo Clinic School of Graduate Medical Education in Rochester, Minnesota. Dr. Woods is board certified by the American Board of Physical Medicine and Rehabilitation in physical medicine and rehabilitation and in sports medicine.
Woods, Ryan R., and Brault, Jeffery S. "Special Population Considerations in the Treatment of Posterior Leg Injuries." Muscular Injuries in the Posterior Leg. Ed. Bryan J. Dixon. Springer US. 141-52. Print, 2016.
Lead author, "Can Ultrasound Be Used to Improve the Palpation Skills of Physicians in Training? A Prospective Study," Mayo Clinic, Rochester, MN, 2015-present.
Patient recruiter and coordinator, "Does Anesthetic Contribute to Symptomatic Relief in Corticosteroid Injections for Knee Osteoarthritis? A Single-Blind Randomized Trial Comparing Corticosteroid/Ropivacaine versus Corticosteroid/Saline Injections," Mayo Clinic Department of Sports Medicine, Rochester, MN, 2015-present.


text:
package com.googlecode.eyesfree.compat.accessibilityservice;

import android.accessibilityservice.AccessibilityService;
import android.accessibilityservice.AccessibilityServiceInfo;
import android.support.v4.view.accessibility.AccessibilityNodeInfoCompat;

import com.googlecode.eyesfree.compat.CompatUtils;

import java.lang.reflect.Method;

public class AccessibilityServiceCompatUtils {
    private static final Method METHOD_performGlobalAction = CompatUtils.getMethod(
            AccessibilityService.class, "performGlobalAction", int.class);
    private static final Method METHOD_getServiceInfo = CompatUtils.getMethod(
            AccessibilityService.class, "getServiceInfo");
    private static final Method METHOD_getRootInActiveWindow = CompatUtils.getMethod(
            AccessibilityService.class, "getRootInActiveWindow");

    public static boolean performGlobalAction(AccessibilityService service, int action) {
        return (Boolean) CompatUtils.invoke(service, false, METHOD_performGlobalAction, action);
    }

    public static AccessibilityServiceInfo getServiceInfo(AccessibilityService service) {
        return (AccessibilityServiceInfo) CompatUtils.invoke(service, null, METHOD_getServiceInfo);
    }

    public static AccessibilityNodeInfoCompat getRootInActiveWindow(
            AccessibilityService service) {
        Object root = CompatUtils.invoke(service, null, METHOD_getRootInActiveWindow);
        if (root != null) {
            return new AccessibilityNodeInfoCompat(root);
        } else {
            return null;
        }
    }
}

redpajama_set_name: RedPajamaGithub


text:
Mastering the Submissions Process to Get a Literary Agent Zoom Seminar, Saturday, February 11th, 2023
2-Part Zoom Seminar
Live Seminar Via Zoom
Starts at 1PM EST/ 12PM CST/10AM PST
Any questions about this class? Use the Chat Button (lower left) to talk with us.
*A recording of this seminar will be made available to enrollees.
Led by an industry-leading literary agent at Trident Media Group, Mark Gottlieb.
Many new writers hoping to become published authors often ask themselves, I've written a book…now what? Chances are, the first thing they need is a literary agent. (Publishing houses do not accept unsolicited submissions from writers unless they come by way of a literary agent). So, how to go about querying literary agencies?
There are so many wrong ways to go about the process, with just a very small list of how to go about it in the right way. This class focuses on the correct methods of obtaining a literary agent and helps simplify the process.
Session 1: Assembling the Perfect Pitch Package & Understanding the Submissions Process
1:00 PM EST - 1:45 PM EST via Zoom
This first section focuses on how writers can assemble their dream team of literary agents and editors for query letter submissions. This section will provide exact models for success, including a mock "ideal" submission in the eyes of agents and editors. The importance of selecting the right title and/or subtitles will be explored. How to perfect one's pitch and a fiction and nonfiction proposal will be explained. The value of having good readers and a team of writers in a group will be discussed. Lastly, this section will go into the exact preparation of the pitch package when in readiness for liftoff. What it means to send one's book directly to publishers will be explored, along with what it is like to work with micropublishers and how to go direct to one's readers. Time for further questions and comments will be afforded toward the end of the session.
Session 2: Finding, Attracting, and Getting the Right Agent
The second session will follow with an exploration as to why every writer really needs to have a literary agent. The process for locating a literary agent will be explained. Next, this class segment will shift to an explanation of how to lure the right literary agent. Lastly, how to land a desired literary agent will be revealed to students. Then, what it means to sign an agency agreement and what to expect next from an agent will be detailed. This will then follow with a description of how to properly conduct relations with literary agents by avoiding mistakes and properly addressing periods of silence. What it means to send one's book out into the world will be discussed. How to handle interest from literary agents—especially when it can result in agony or ecstasy—is a deeper understanding participants will gain. Time for further questions and comments will be afforded toward the end of the session.
COURSE TAKEAWAYS:
How to assemble the perfect pitch package for submission
Locate, lure and land the right literary agent
Gain a better understanding of the submissions process
Properly manage rejections or potentially avoid them altogether
Mark Gottlieb is a highly-ranked literary agent in overall deals and other categories. Using that same initiative and insight for identifying talented writers, he is actively building his own client list of authors. Mark Gottlieb is excited to work directly with authors, helping to manage and grow their careers with all of the unique resources that are available at book publishing's leading literary agency, Trident Media Group. During his time at Trident Media Group, Mark Gottlieb has represented numerous New York Times bestselling authors, as well as award-winning authors, and has optioned and sold books to film and TV production companies. He previously ran the agency's audiobook department in addition to working in foreign rights. Mark Gottlieb is actively seeking submissions in all categories and genres and looking forward to bringing new and established authors to the curious minds of their future readers.
"To find someone in the publishing world these days who possesses such style and grace…a throwback. Crown moldings and brass door knocker in a world of prefab housing."
—Lesley Kagen, New York Times bestselling author
"He is professional, knowledgeable, and deeply cares about the careers of his clients. …I'm lucky to have Mark in my corner!"
—Alan Hlad, USA Today bestselling author
"My writing career would never have advanced as fast or as far without Mark's help." —James Breakwell, bestselling author
"He goes above and beyond his work expectations by cultivating caring relationships with his clients, always expressing empathy and patience. He is kind, supportive and knows what he's doing."
—Ruby Karp, author of Earth Hates Me
ONLINE COURSE STRUCTURE:
This Workshop will meet via Zoom on Saturday, February 11th, 2023.
Session 1 will be 1:00 PM – 1:45 PM EST
15-minute Break Between Sessions
*Recordings of all sessions will be made available to everyone who enrolls.
You can pay for the course in full or use Shop Pay or Affirm to pay over time with equal Monthly Payments. Both options are available at checkout.
Mark Gottlieb | Live via Zoom
The seminar is fully ONLINE and meets via Zoom
#Nonfiction
#Online-Class
#Seminars
#Writing-for-Children


Group Discussion is a very important step in acquiring the elusive step towards selection in a company. IHere are few topics that are collected and I will certainly help you all. These are the topics that are generally asked or are likely to be asked. Along with the topics the broad points along which these topics can be discussed are also given.
Here are some very useful tips, guidelines & common mistakes that should be avoided to handle group discussions in an effective way. Learn how to score points in a GD.


Sunday's Christmas fair at the Benham Sports Arena was really fun and festive! Lots of different stalls and music throughout the day. Here are a few pictures of the stall and my handmade goodies. The first one was taken early on… I'd only just got my coffee!


text:
"Incredible Things" is Taylort's fourth perfume. It's name comes from Taylor's song "Blank Space", using the lyric "I could show you incredible things". It's believed that the look of the bottle was inspired by Taylor's paintings. It was first released in the fall of 2014.
Many products have been made using the scent of "Incredible Things". It has been made as not only a perfume but as a body lotion, body wash, bath gel and fine fragrance mist.
The "Incredible Things" bottle has a colorful base with different water colors and Taylor's silhouette (based on this picture, taken at the CMA Awards 2013) with a gold cap. On the bottom of the bottle there is text saying "Taylor Swift Incredible Things" in black.
A reflection of Taylor's romantic spirit and modern artistry, Taylor Swift "Incredible Things" is an intriguing "floriental" fragrance. Like Taylor herself, the scent is fresh, feminine, and unforgettable. The scent is composed of velvety petals and creamy woods wrapped in a soft veil of vanilla and musk. Pink pepper, sparkling grapefruit, and wild passion flower create desire. Inspired by the lyrics from Taylor's song "Blank Space", the rich sophistication of this fragrance instantly captures attention.


text:
Chemainus Legion president Mike Beggs and first vice-president Janet Mitchell visited Chemainus Secondary School (CSS) Friday
Chemainus Secondary student paints prize-winning poster
Hannah Holmes placed third in the B.C.-Yukon division of the Royal Canadian Legion's Remembrance Day poster contest.
Nick Bekolay
Hannah Holmes, a Grade 11 student at Chemainus Secondary School (CSS), was recognized by the Royal Canadian Legion (RCL) last week after placing third in the B.C.-Yukon division of the RCL's national Remembrance Day poster contest.
President Mike Begg and first vice-president Janet Mitchell of the Chemainus Legion delivered a certificate and cheque to Holmes at CSS April 12, in recognition of Holmes' accomplishment.
Holmes' prize-winning poster, titled Remember the ultimate sacrifice, resulted from a social studies project assigned by her teacher Janet Ruest last November. Ruest, head of CSS's social studies department, said the assignment revolved around a theme of remembrance and "the idea of passing remembrance on from generation to generation."
Holmes "captured that beautifully in her poster," Ruest added.
Holmes used gouache — a paint similar to watercolours but more opaque — to render her interpretation of remembrance. Her poster features snapshots of the Royal Canadian Navy and Air Force and scenes of remembrance set against a silhouette of soldiers traversing a First World War battlefield at sunset. A hand-painted reproduction of a wartime photo of her great-great-uncle rests below the red banner bearing the poster's title.
Holmes' great-great-uncle was imprisoned in Stalag Luft III — a German prisoner-of-war camp where Allied air force personnel were detained during the latter half of the Second World War. Family lore suggests he helped dig one of three tunnels through which 76 prisoners escaped from the camp on the night of March 24, 1944 — the real-life prison break that inspired the movie The Great Escape.
"I've met him once," Holmes said. "I went and visited him in Saskatchewan. From what I've heard, he was a digger in one of the three tunnels, but he didn't actually escape."
German soldiers recaptured 73 of the 76 men in the days and weeks following the escape, Holmes said, and according to BBC Radio 4, 50 of these men were then "systematically executed on orders from German High Command."
Holmes's submission won first place at the branch and zone levels, Mitchell said, before advancing to the B.C./Yukon Command competition, where she placed third. That earned Holmes a certificate and a cheque for $150 from the Chemainus Legion.
The RCL hosts an annual nationwide contest for students from kindergarten through Grade 12, Mitchell said, and participating students submit entries in four categories: essays, poetry, black-and-white posters, and colour posters. The Chemainus Legion received 283 entries from area schools this year, Mitchell added, and distributed $1,985 in prizes in return.
Holmes is one of several students from CSS to have benefitted from the generosity of the Chemainus Legion in recent years.
"In 2000, one of our students won the best essay in the province," Ruest said. "In 2003, another student won the best essay. In 2005, Jake Shepherd's poem won first in the province and was second in all of Canada — at the Dominion level — and now Hannah's up there again. So for a little school, we do pretty well."
"I wanted to comment on how generous our local Legion is," Ruest added. "A lot of Legions use [poppy funds] for their own veterans and their own services. Our Legion has felt it's important to give back to the youth, making that connection of remembrance back-and-forth. And this Legion in particular is very generous with the amount of money that they give at the local level. More so than many other Legion branches. I just want to thank them for thinking that's important, because the students definitely appreciate [it.]"
How will Holmes spend her winnings?
"Part of it is probably going towards buying brushes," Holmes said, "And the rest of it will go towards my education."
Renters workshop visits Ladysmith Thursday
Learn more about your septic system this Thursday


text:
"""Miscellaneous small utility functions.

    vol(vol=None) - Get or set volume using aumix.

    progress(ratio, length=40, col=1, cols=("yellow", None, "cyan"),
            nocol="=.")
        Text mode progress bar.

    yes(question, [default answer])
        i.e. if yes("erase file?", 'n'): erase_file()

    color(text, fg, [bg])
        Colorize text using terminal color codes.

    beep(times) - Beep terminal bell number of times.

    ftime(seconds) - returns h:m:s or m:s if there's no hours.

    Term() - terminal stuff
        term.size() => height, width
        term.clear() => clear terminal
        term.getch() => get one char at a time

Andrei Kulakov <ak@silmarill.org>
"""

import os
try:
    import commands
except:
    pass
import time
try:
    from termios import *
except ImportError:
    from TERMIOS import *
from types import *
from sys import stdin, stdout

dbg = 1
enable_color = 1
hotkeycol = "red"

colors = dict([c.split() for c in (     # make dict {"red": "31", ...}
  "black 30, red 31, green 32, brown 33, blue 34, purple 35, cyan 36, lgray 37, gray 1;30, "
  "lred 1;31, lgreen 1;32, yellow 1;33, lblue 1;34, pink 1;35, lcyan 1;36, white 1;37"
).split(', ')])

"\033]Pg4040ff\033\\"

class AvkError(Exception):
    def __init__(self, value): self.value = value
    def __str__(self): return repr(self.value)

def debug(*msgs):
    if dbg:
        for m in msgs: print( '###  ', m)

def replace(val, lst):
    """ Replace patterns within `val`."""
    for pat, repl in lst:
        val = val.replace(pat, repl)
    return val

def split(fname):
    """ Split filename into (name, extension) tuple."""
    lst = fname.split('.')
    if len(lst) == 1: return fname, None
    else: return str.join(lst[:-1], '.'), lst[-1]

def vol(vol=None):
    """ Set or show audio volume.

        Uses external mixer called aumix. One optional argument, vol, may
        be an int or a string. If a string, it can be of the form "+10".
    """
    if vol: os.system("aumix -v%s" % vol)
    else: return commands.getoutput("aumix -vq").split()[1][:-1]

def progress(ratio, length=40, col=1, cols=("yellow", None, "cyan"), nocol="=."):
    """ Text mode progress bar.

        ratio   - current position / total (e.g. 0.6 is 60%)
        length  - bar size
        col     - color bar
        cols    - tuple: (elapsed, left, percentage num)
        nocol   - string, if default="=.", bar is [=======.....]
    """
    if ratio > 1: ratio = 1
    elchar, leftchar = nocol
    elapsed = int(round(ratio*length))
    left = length - elapsed
    bar = (elchar*elapsed + leftchar*left)[:length]

    if col: return color(' '*elapsed, "gray", cols[0]) + color(' '*left, "gray", cols[1])
    else: return elchar*elapsed + leftchar*left

def yes(question, default=None):
    """ Get an answer for the question.

        Return 1 on 'yes' and 0 on 'no'; default may be set to 'y' or 'n';
        asks "Question? [Y/n]" (default is capitalized). Yy and Nn are
        acceptable. Question is asked until a valid answer is given.
    """
    y, n = "yn"
    if default:
        if default in "Yy": y = 'Y'
        elif default in "Nn": n = 'N'
        else:
            raise AvkError("Error: default must be 'y' or 'n'.")

    while 1:
        answer = raw_input("%s [%s/%s] " % (question, y, n))
        if default and not answer:
            return (1 if default in "Yy" else 0)
        else:
            if not answer: continue
            elif answer in "Yy": return 1
            elif answer in "Nn": return 0

def no(question, default=None):
    return not yes(question, default)

def color(text, fg, bg=None, raw=0):
    """ Return colored text.

        Uses terminal color codes; set avk_util.enable_color to 0 to return plain un-colored text.
        If fg is a tuple, it's assumed to be (fg, bg). Both colors may be 'None'.

        Raw means return string in raw form - for writing to a file instead of printing to screen.
        Leave default if not sure.
    """
    # init vars
    xterm, bgcode = 0, ''
    if not enable_color or not fg:
        return text
    if not isinstance(fg, str):
        fg, bg = fg
    opencol, closecol = "\033[", "m"
    tpl = "\033[%sm"
    if raw:
        opencol, closecol = r"\033[", r"\033[0m"
    # clear = opencol + '0' + closecol
    clear = tpl % 0
    if os.environ["TERM"] == "xterm":
        xterm = 1

    # create color codes
    if xterm and fg == "yellow":    # In xterm, brown comes out as yellow..
        fg = "brown"
    # fgcode = opencol + colors[fg] + closecol
    fgcode = tpl % colors[fg]
    if bg:
        if bg == "yellow" and xterm: bg = "brown"

        try: bgcode = opencol + colors[bg].replace('3', '4', 1) + closecol
        except KeyError: pass

    return "%s%s%s%s" % (bgcode, fgcode, text, clear)

def beep(times, interval=1):
    """Beep terminal bell specified times with `interval` seconds (float or int)."""
    for t in range(times):
        print( '\a')
        time.sleep(interval)

def ftime(seconds, suffixes=['y','w','d','','',''], separator=':', nosec=False):
    """ Takes an amount of seconds and turns it into a human-readable amount of time.
        ftime(953995) => 1w:04d:00:59:55
        if `nosec` is True, seconds will be omitted from output.
        adapted from code by: http://snipplr.com/users/wbowers/
    """
    t = []
    parts = [ (suffixes[0], 60 * 60 * 24 * 7 * 52),
              (suffixes[1], 60 * 60 * 24 * 7),
              (suffixes[2], 60 * 60 * 24),
              (suffixes[3], 60 * 60),
              (suffixes[4], 60),
              (suffixes[5], 1)]

    # for each time piece, grab the value and remaining seconds, and add it to the time string
    if nosec:
        del parts[-1]
    for n, (suffix, length) in enumerate(parts):
        value = int(seconds) / length
        if value > 0 or t:                      # skip parts until we get first non-zero
            seconds = seconds % length
            fmt = "%02d%s"
            if not t and n+1 < len(parts):
                fmt = "%d%s"              # don't pad the first part with zeroes
            t.append(fmt % (value, suffix))
    if not t: t = ['0s']
    elif len(t) == 1 and not nosec: t[0] += 's'
    return str.join(t, separator)

# print ftime(105, nosec=True)

class Term:
    """ Linux terminal management.

        clear   - calls os.system("clear")
        getch   - get one char at a time
        size    - return height, width of the terminal
    """
    def __init__(self):
        self.fd = stdin.fileno()
        self.new_term, self.old_term = tcgetattr(self.fd), tcgetattr(self.fd)
        self.new_term[3] = (self.new_term[3] & ~ICANON & ~ECHO)

    def normal(self):
        """Set 'normal' terminal settings."""
        tcsetattr(self.fd, TCSAFLUSH, self.old_term)

    def clear(self):
        """Clear screen."""
        os.system("clear")

    def cline(self):
        """Clear line."""
        stdout.write('\r' + ' '*self.size()[1])
        stdout.flush()

    def curses(self):
        """Set 'curses' terminal settings. (noecho, something else?)"""
        tcsetattr(self.fd, TCSAFLUSH, self.new_term)

    def getch(self, prompt=None):
        """ Get one character at a time.

            NOTE: if the user suspends (^Z) running program, then brings it back to foreground,
            you have to instantiate Term class again.  Otherwise getch() won't work. Even after
            that, the user has to hit 'enter' once before he can enter commands.
        """
        if prompt:
            stdout.write(prompt)
            stdout.flush()
        self.curses()
        c = os.read(self.fd, 3)
        self.normal()
        try:
            return unicode(c)[2:-1]
        except NameError:
            return str(c)[2:-1]

    def size(self):
        """Return terminal size as tuple (height, width)."""
        import struct, fcntl
        h, w = struct.unpack("hhhh", fcntl.ioctl(0, TIOCGWINSZ, "\000"*8))[0:2]
        if not h:
            h, w = 24, 80
        return h, w


text:
Q: how to work with the loader when the screen is rotated I try to use Loaders instead AsyncTask.I can not figure out how to correctly organize the conservation status when the screen is rotated. I receive information from Json and trying create list.
public class FragmentWeatherTestApplication extends Fragment
        implements LoaderManager.LoaderCallbacks<List<WeatherItem>> {
@Override
public void onCreate(Bundle savedInstanceState){
    super.onCreate(savedInstanceState);
    getLoaderManager().initLoader(0,null,this).forceLoad();
}

 ...

@Override
public Loader<List<WeatherItem>> onCreateLoader(int id, Bundle args) {
    Log.i(TAG, "onCreateLoader");
    return new FetchWeatherLoader(getActivity());
}

@Override
public void onLoadFinished(Loader<List<WeatherItem>> loader, List<WeatherItem> data) {
    Log.i(TAG, "onLoadFinished");
    mItems = data;
    setupAdapter();
}

@Override
public void onLoaderReset(Loader<List<WeatherItem>> loader) {
    Log.i(TAG, "onLoaderReset");
}

   ....

  private static class FetchWeatherLoader extends AsyncTaskLoader<List<WeatherItem>>{

    public FetchWeatherLoader(Context context) {
        super(context);
    }

    @Override
    public List<WeatherItem> loadInBackground() {
        return new OpenWeatherFetch().fetchItems();
    }
}

redpajama_set_name: RedPajamaStackExchange


Vehicle wraps are the most cost-effective form of advertising in New Orleans, Louisiana! BDW specializes in vehicle wraps and believes in producing the highest quality auto wraps no matter what we are wrapping. We are one of the very few wrap companies that do not outsource any part of its design, print or install processes. The entire process from the design to print and install of the vinyl wrap is performed in-house by our full-time staff. This allows us to control the quality of every project we do. Our clean print room helps keep your prints clear of dust and debris which goes hand & hand with our 2 climate controlled wrap shops allowing us to produce stunning quality wraps. BWD can fit an entire charter bus, 18 wheeler and just about any boat into our climate controlled wrap shop. This allows us to do jobs at a higher quality on site in a climate that is best to work e vinyl while wrapping as well as to eliminate dust and bugs flying under your wraps.
Vehicle Wrap & Graphic Design – Key points visualized within 3 seconds.
Quality Materials – Cheap is not always good trust the materials being put on your vehicle.
Quality Installers – Do not harm your vehicle by the lack of experience with installers. We treat your vehicle like our own.
BDW can wrap more than just a truck or car, we can wrap your motorcycles, trailers, food trucks, 18 wheelers/semi trucks, buses, golf carts, boats, air boats, air planes, segways and much more! We can also wrap your vehicles windows and pretty much anything else that may help with your advertising.
You may not want to do any advertising but are debating a color change on your vehicle with a paint job, well we can do a vinyl color change as well.
@blakeshelton Can u come to NewOrleans so I can wrap your truck! & when you come can u please stop by Papa G's in Ada, OK & get me a pizza!
@Matt_Staaxx No, he does not!
bigdaddywrap.com The best vehicle graphics in New Orleans and all of Louisiana.
@BigDaddyWrap Awesome video about that vehicle you wrapped and your company tour. Loved it.
@WebAtude Thanks. We love wrapping vehicles and take pride in our work!


The hemolytic activity of NDV, as present in allantoic fluid or suspended in phosphate buffered saline is greatly enhanced by dialysis against various media and by the diluents used in the titrations. It is most pronounced after dialysis against distilled water with subsequent restoration of isotonicity by sodium chloride and dilution in isotonic sodium citrate. The hemolytic activity of such preparations is further increased by various physical manipulations, i.e. sonic vibration, repeated freezing and thawing and osmotic shock. No evidence has been obtained as yet to indicate that these procedures cause the disruption of NDV into smaller hemolytic units.


Ryan Canter, Vice President Sales and Marketing, Centrifugal at Epic International, discusses the centrifugal compressor aftermarket, the skills shortage, and how to improve compressor maintenance.
Tell our readers briefly about Epic.
Headquartered in Houston, TX, Epic International was founded in 2015 and serves the global energy and industrial engine-compressor market with parts, repair services, and field service. Our entire business is focused on the engine-compressor aftermarket without the distraction of a new equipment business. Epic Air, a division that focuses on centrifugal equipment, became a resource for the centrifugal compression aftermarket with the 2016 acquisition of Air Relief of Mayfield, KY. We have two established domestic repair facilities (Houston and Mayfield, Kentucky), a team of OEM factory-trained technicians, and the new Air Relief and TurboLogix brands. This allows us to serve the world's 50-60 Hz market and comply with major quality requirements.
What new services have you recently added?
In the spring of 2018, we became a full supplier of parts, repairs, field service, and technical support for Atlas Copco HP, ZH, ZT and ZR rotary screw compressors.
What trends have you observed?
The demand for high-quality manufactured parts, and the maintenance cycles that consume such components, have not changed much over the years. What has changed is the availability of key components as equipment owners and suppliers have cut inventories to reduce long-term costs and improve cash flow. This trend has opened up an opportunity for those compressor component suppliers with a customer-service mindset and that are willing to stock inventories in multiple locations globally.
What trends have you observed with centrifugal compressor repair?
As the cost of impellers, diffusers, and inlets has risen, demand for repair services has increased. This has been a trend in the North American market for some time. But we are starting to see much higher demand for creative and quality repair services in Europe and the Far East. Epic has repaired rotors from 37 nations in the last 24 months, which is an increase of 15 nations during the previous 12 months.
We recently added a full-service aftermarket program called EpicCare that allows the equipment owner to turn the entire compressor maintenance program over to Epic Air. This "contract maintenance" program combines planned maintenance, parts discounts, extended warranties, and our new TurboLogic controls system to provide a maintenance program that improves compressor performance and reduces maintenance costs.
What trends have you observed in field service?
The most impactful trend is retirement of skilled field service professionals. As workforces diminished, companies have not replaced these workers quickly. This fosters the need for full-service turnkey suppliers with senior field service staffs and mechanics. It is expensive and difficult to find skilled people for this kind of work. Customers are turning to aftermarket suppliers to supplement their own maintenance efforts.
How has the experience level of operations and maintenance personnel changed over time?
There has been a huge loss of experience in the field which drives organizations like Epic to focus on technical training and continuous education of employees and customer personnel. We conduct centrifugal compressor seminars in the U.S., Europe, and Asia. We cover theory, operations and maintenance.
What would you recommend plants do when they are experiencing heavy personnel losses?
Reach out to technical schools, create internship or apprentice-type programs, and invest in internal training. These are long-term commitments that must be planned and funded carefully, or the results will be less than inspiring.
In lieu of these efforts, there are many contract-type services offered by compressor repair suppliers. Turning your maintenance program over to a repair expert can reap many benefits if the program is jointly planned and executed.
Is there any company news you wish to communicate?
We recently hired Mike Pelezo as our Vice President of Service and Operations, and John Sargent as our Chief Executive Officer. Both are compressor industry veterans with a combined 50+ years of experience at companies like Cameron, Schlumberger, Spitzer and El Paso Corp.


text:
A look inside the friendship between Dwyane Wade and Udonis Haslem
Miami Heat shooting guard Dwyane Wade (3) and Miami Heat power forward Udonis Haslem (40) bump fists after Wade was fouled by Indiana Pacers power forward Tyler Hansbrough (50) at AmericanAirlines Arena in Miami, FL. (Allen Eyestone/The Palm Beach Post)
MIAMI — Dwyane Wade took the stage at Regatta Park on Saturday morning to thank the riders who came out to the D. Wade CommUNITY Bike Ride. But Wade didn't leave the stage without professing his love for one particular rider.
Before walking off, Wade called Udonis Haslem to the stage. As Haslem walked up, the tight bond the two formed over the past 13 years immediately became visible.
"I love that guy," Wade said of Haslem. "I want you all to know that one of the hardest things about me leaving this city is the fact that I wasn't going to be playing with UD and I wasn't going to be in the locker room with UD. That was the hardest part of this decision I had to make to go back home.
"Blood couldn't make us any closer, man. I appreciate this guy for all the fines he took for taking up for me. As I told him, I scored 20,000 points and I give him 10,000 of them for the screens he set for me to get there."
[Miami Heat 2016 training camp preview: Point guards]
[Dwyane Wade still waiting on email from Heat president Pat Riley]
[Want more Heat news sent directly to your Facebook feed? Make sure to like our Heat Facebook page]
Haslem looked to be caught off guard by Wade's comments, but it didn't stop him from showing his love for the 12-time All-Star.
"Sometimes people say that blood is thicker than water. But with me and this guy, it's not about blood," Haslem said on stage to Wade and the crowd. "It's about the blood we put in.
"Regardless of what situation or what decision he made, our relationship won't change and our relationship is going to be stronger. He's always going to be a part of my situation, I'm always going to be a part of his situation and he's always going to be a part of Miami. He's done a lot for this city and he's done a lot for me."
Wade, 34, and Haslem, 36, have spent the first 13 seasons of their NBA careers together. But with Wade off to Chicago and Haslem staying in Miami, they will face off as opponents for the first time on Nov. 10.
"I look forward to the competition," Wade said. "That's one thing neither one of us has ever done, run away from competition. I look forward to coming back on Nov. 10 and enjoying that moment with this community and also trying to kick y'all butt and get a win."
But toward the end of his time on stage, Wade made an interesting comment that has made some wonder if he's open to ending his career with the Heat.
"I made a promise to [Haslem] that we were going to finish our careers together," Wade said. "As of now, I didn't hold up my end of the bargain, so I have to make it up to him eventually."
"As of now." Does that mean Haslem and Wade could still end their careers together?
Wade signed a two-year, $47 million contract with the Bulls, but the second year is a player option. That means Wade can opt to leave Chicago next offseason.
It's too early to think about that possibility right now, but it sounds like it has already crossed Haslem's mind.
"I'm going to damn sure try," Haslem said to the Miami Herald when asked if Wade could end up back in Miami. "I mean, I don't know. I guess I've got to wait until next summer to see how that goes. But, I never give up without a fight."
Author Anthony ChiangPosted on September 19, 2016 September 19, 2016 Categories 2016 offseason, Anthony Chiang, Dwyane WadeTags Dwyane Wade, heatzone, Miami Heat, sports, sportsfront, Udonis Haslem
One thought on "A look inside the friendship between Dwyane Wade and Udonis Haslem"
Pingback: Dwyane Wade says returning to Miami Heat is 'not a focus' ‹ King James
Previous Previous post: Miami Heat 2016 training camp preview: Point guards
Next Next post: Miami Heat 2016 training camp preview: Shooting guards


text:
Stassen is een Belgisch bedrijf uit Aubel dat cider produceert op basis van appelen. De onderneming werd in 1895 opgericht door Léon Stassen (1852-1931), die cider produceerde met appelen uit zijn eigen boomgaard. Na enkele eigendom van Bulmers en S&N is het bedrijf in 2008 weer eigendom van de familieleden van de vierde generatie, maar werd in 2012 door Heineken verworven.

Overnamen

Vanaf de jaren negentig werd Stassen marktleider van ciders op de Belgische en Nederlandse markt, door de introductie van hun gearomatiseerde ciders.
In 1992 werd Stassen overgenomen door het Engelse Bulmer, een sectorgenoot die zijn marktaandeel in Europa wilde vergroten. In 2003 werd Bulmer op zijn beurt overgenomen door de Engelse brouwerij Scottish & Newcastle, dus ook Stassen. Toen Scottish & Newcastle in 2008 in handen kwam van Heineken, kocht de vierde generatie van de stichtende familie uit Aubel het bedrijf weer vrij.  In juni 2012 kocht Heineken het bedrijf terug.

Producten
De activiteiten bestaan uit de productie en distributie van (gearomatiseerde) ciders Stassen van allerlei vruchten, de alcoholvrije ciders Degré Zéro en de feestdrank voor kinderen Kidibul. Stassen produceerde in 2007 meer dan 25 miljoen liter cider. Momenteel is nagenoeg 80% van de productie bestemd voor de uitvoer. Het blijft een bevoorrecht leverancier aan Scottish & Newcastle.

Externe link
 Website van Stassen

Belgisch voedingsmiddelenfabrikant
Bedrijf met zetel in Wallonië
Aubel

redpajama_set_name: RedPajamaWikipedia


Heightened levels of the cytokine protein IL-1 in the blood are known as a common denominator in a broad range of diseases involving chronic inflammation, including obesity, diabetes, atherosclerosis, rheumatoid arthritis and lupus. Excessive IL-1 is known to correlate with increased production by the bone marrow of aggressive immune cells, which can damage other tissues, at the expense of cells that maintain healthy blood and immune system. But whether IL-1 itself was causing these changes, or merely acting as a bystander was not clearly understood.
Now stem cell biologists at UC San Francisco have demonstrated that IL-1 itself directly transforms the blood system by driving blood stem cells (termed "hematopoietic stem cells" or HSCs) in the bone marrow to switch away from their restorative, rejuvenating role in blood renewal and toward emergency production of immune cells.
Fortunately, the researchers also demonstrate that the negative consequences of chronic IL-1 exposure on blood stem cells are rapidly reversed when the immune molecule is removed, supporting ongoing clinical attempts to use IL-1-blocking drugs to treat diseases of chronic inflammation such as cardiovascular disease, diabetes, and arthritis and even as a way to slow aging.
In their new paper — published online April 25, 2016, in the journal Nature Cell Biology — Passegué and her team performed experiments in cell culture as well as in live mice showing that IL-1 exposure directly drives HSCs toward emergency production of myeloid cells of the acute immune system – such as monocytes, neutrophils and macrophages — by activating a molecular network driven by the myeloid commitment gene Pu.1.
Additional mouse experiments showed that while brief IL-1 exposure produces a wave of myeloid cells capable of responding to tissue damage or fighting off an acute infection without significant negative consequences, chronic exposure to IL-1 for up to 70 days drastically impaired the ability of HSCs in the bone marrow to perform their normal, non-emergency role of maintaining and regenerating the blood and immune systems.
Fortunately, the researchers discovered that the negative effects of IL-1 on HSCs are short lived. When the researchers took blood stem cells from mice that had been chronically exposed to IL-1, deprived them of IL-1 for a few weeks, then transplanted them into mice whose blood marrow had been fatally damaged, the transplanted cells flourished, regenerating a normal blood system with virtually no sign of their long previous exposure to IL-1. These results support the notion that blocking IL-1's effects on the stem cells of the bone marrow may be a potent treatment for chronic inflammation.
The results uncover a new regulatory circuit that clarifies how IL-1 shifts the blood-generating cells of the bone marrow from self-renewal toward acute needs, with important consequences for the functionality of the blood system in chronic inflammatory conditions. In addition, the results suggest that bone marrow transplant failures may in some cases be due to high levels of IL-1, which is produced in response to bone marrow injury and could cause HSCs to fail the massive regeneration challenge required for successful transplantation.
Importantly, Passegué says, the discovery that the damaging effects of IL-1 on HSC function are reversible has important translational implications for the use of existing FDA-approved IL-1 blockade therapies to restore HSC function and blood homeostasis for millions of patients suffering from chronic inflammation worldwide. "Understanding this mechanism helps us understand why these drugs are such promising treatments for patients with chronic inflammation," she said.
Passegué suspects that IL-1 could play a similarly double-edged role in a variety of tissues via direct reprogramming of their stem cell populations. If so, she says, reducing chronic IL-1 exposure, may be an important approach for improving stem cell health and tissue function in the context of both inflammatory disease and normal aging.
Researchers on the paper include first author and co-corresponding author Eric M. Pietras, PhD; Cristina Mirantes-Barbeito; Sarah Fong; SiYi Zhang; Ranjani Lakshminarasimhan; Chih Peng Ching; and José-Marc Techner of UCSF; Dirk Loeffler, PhD, and Tim Schroeder, PhD, of ETH Zurich, Switzerland; Larisa V. Kovtonyuk, PhD, and Markus G. Manz, MD, of University Hospital and University of Zurich, Switzerland; Britta Will, PhD, and Ulrich Steidl, MD, PhD of Albert Einstein Medical College, New York; and Claus Nerlov, PhD, of Oxford University. Pietras is now an assistant professor at the University of Colorado Denver.
The researchers were supported by the National Institutes of Health (grants R01 HL092471, F32 HL106989 and K01 DK09831), the California Institute of Regenerative Medicine (CIRM), the Institute of Health Carlos III, the Swiss National Science Foundation, and the Leukemia and Lymphoma Society. The researchers declare no competing financial interests.


Jussie Smollett has really blossomed into not only a great actor, but also a great musician and artist. Jussie's decision to leave FOX right now to pursue other opportunities is understandable; Especially with more lucrative deals and offer's he's likely receiving from the immersive popularity of the show him being on. Not only for the drama but its musical aspect. Read More to find out what made him finally decide to leave one of FOX's Hit Television Series.
Rumor has it Jussie got tired of being looked over when it came to his salary ; He believed FOX felt the true stars of the show are Taraji P. Henson & Terrence Howard. All Jussie wanted was some of their same perks and a small increase in his salary and they told him there was nothing left in the budget to do so. I can see how that can feel like a slap in the face considering how talented he is.
When a person doesn't feel like you value them or their talent, it can make someone move around real quick. I wonder what the show is going to be like without Jamal Lyons, they are going to have to pull out all kinds of stops to make this work.
← AZEALIA BANKS TWITTER RANTS COST HER BIG!!


Is water a God-given right?
Most people think access to water is a God-given right, but that couldn't be further from the truth. History is filled with legal precedents trying to resolve basic water rights; essentially sorting out the "haves versus the have-nots". Even today, in water-scarce areas like South Africa and the Middle East, unstable governments are allowing private … Continue reading Is water a God-given right?