You don't get a pregame! College Football Gameday is your pregame! You'll listen to Drew Brees talk about teams he only vaguely knew existed before an intern whispered their names in his earpiece right this second and like it! Lee Corso had a freaking stroke, man–screw your team and your game! Let the guy with a stroke put on the wrong mascot head and clap your hands and shut up about the pregame! You got it?
— Auburn receives the opening kickoff, which is nice, because Chris Todd can get the forthcoming Festival of 60-Yard Touchdown Passes started early. Or, alternatively, Arkansas can get their Festival of Screen Passes Ruined by Well-Timed Blitzes underway, which they do on both first and third downs. So Auburn starts the game with a punt, but against this defense I'm sure that's just a one-time thing and not at all a horrible black cloud of an omen that foretells a day of endless sadness and bottomless woe or anything.
— On Mallet's second dropback he experty feathers a pass low and just behind a well-covered Michael Smith, who makes a solid adjustment to scoop it up for a first down. Good that those two appear to be on their game. Yes. Good.
— Mallett runs for a first down on 3rd-and-7 (bulldozing an off-balance Neiko Thorpe in the process) even though he has the agility and foot-speed of Bob Griese. (The potentially senile color commentator Bob Griese, mind you, not Miami Dolphins quarterback Bob Griese.) This is because Auburn is an Equal Opportunity Third Down Quarterback Scramble for First Down Provider.
— After another 3rd-and-7 conversion which doesn't make me want to slug holes in the wall with a Maglite at all, it's 2nd-and-1 on the Auburn 15, and Bynes is flagged for a bit of a grab on D.J. Williams as the Hog tight end comes across the middle. Looks like they're going to be calling it tight, Auburn, but I have full confidence you'll be able to adjust and avoid any more calls like there. Full confidence.
— Williams to the 4, anonymous fullback to the 2, anonymous jumbo back plows in, 6-0 Hogs. The push made by the defensive line on those last two plays was closer to pull, I think.
— Stevens blocks the extra point after a bad snap, and usually I would think "HaHA! That will come back to haunt you, Hogs! Missed extra points always come back to haunt you! It happens so often the entire sports industry has never even bothered to come up with a different phrase than 'haunt you,' which it's going to do!" But in a game with these two offenses … eh, there'll be enough time to make up for it later.
— McCalebb is hurt returning the kickoff to the 19, and Byron Isom celebrates his return to the lineup with a false start, so Auburn starts their drive 1st-and-15 on their own 14 … and already, the memories of Auburn's previous pratfalls against lightly-regarded Arkansas teams are bubbling up. Make it stop, offense. I don't like those memories.
— Sorry, guys, I know you're trying, but 1. Lucky first-down catch that flies directly through the hands of Hog defender 2. Run for nothing 3. Horrible Fannin drop 4. Incompletion with all day for Todd to throw 5. Punt does not make it stop.
— Hogs go three-and-out–nice job there, D–and Auburn takes over at their own 25. No, they take over at their own 20 after McCain false starts. That's two first-down penalties in two drives after starting the opening drive with a three-yard loss. Because the offense just likes the challenge of second- and third- and long, I guess.
— This is more like it: Arkansas busts a coverage in that wonderful way Arkansas busts coverages, Zachery's so open various grandmothers could get the ball to him, Todd has plenty of time to stand in and fire, it's the simplest of touchdowns … and Todd overthrows him by a good four yards. Forget missed extra points, that is going to do some serious, Kathryn Tucker Windham-grade haunting if Auburn doesn't score on this drive … and one failed option and one useless check-down later, they don't.
–The quarter ends with the Hogs just across midfield and facing a 3rd-and-6 … meaning that for the first time all season, Auburn has been held scoreless for an entire quarter. Good-bye, quarter-scoring streak. We had some good times together, didn't we? I know I won't forget them any time soon. Please come back to visit. Maybe even stay a while? I know a lot of SEC teams don't seem interested in you hanging around, but forget Georgia and Ole Miss and those snobs at Vandy–you're always welcome at Auburn, quarter-scoring streak. See you later.
— 4th-and-5 Hogs after a short completion, and here's Mike Blanc, getting his hand up yet again to deflect a pass. How he manages to be this good at a skill this … esoteric, man, damned if I know. Griese and Spielman somehow miss the fact the ball's trajectory dramatically changed after it crossed the line of scrimmage and spend a good 30 seconds giving Mallett a full serving of undeserved hell. Excellent work there, gents.
— Auburn needs something, anything positive to happen on first down, so they go to their bread-and-butter swing pass to Fannin, who holds onto the ball this time … even as Trott's whiffed horribly on a block and the Hog LB just crushes him for a loss of four*. So far, Auburn has faced 2nd-and-12, 2nd-and-9, 2nd-and-9, 2nd-and-15, and now 2nd-and-14. Gee, why aren't they moving the ball? One short completion and one short incompletion later, it's punting time. Again.
— Because Auburn's defense doesn't have enough working against it being on the road against one of the SEC's best offenses and watching Auburn's offense make one first down in four possessions, Etheridge takes a post-play swing at a Hog's facemask. 15 yards, schmifteen schmards.
— Another flag, this time on Thorpe for defensive holding, and sure enough, he leaves his hand on the receiver's outside shoulder a second too long as the Hog tries to make his cut. It's a little on the ticky-tack side, but it's there and it does help disrupt the timing on the pass, which falls incomplete–Auburn can't complain.
— You can't give a Petrino offense 25 free yards and expect not to get punished, and sure enough, the very next play Daren Bates misses a tackle on Michael Smith and it's a Hog touchdown. 13-0.
— After that drive and with as little time as Auburn's offense has spent on the field, the Tigers have to pick up some first downs and chew a little bit of clock this drive, or the defense is screwed the proverbial six ways from Sunday. Hopefully Fannin can give them some good field position on thsi kickoff return, he's got a little bit of a seam and I think he can AAAAAAAUUUUUUUUGGGGGHHHH.
— Yup: simple check-down to Williams (under pressure that would have to get dramatically more intense to even be "light") gains 18, perfectly placed ball from Mallett to Crawford in man-to-man against Thorpe is good for 16 and the touchdown. 20-0. Thorpe can't cover him any better, but Mallett couldn't have thrown it any better, either, and I don't see any way back for Auburn given how exhausted our defense is and how well Mallett is playing. The only question is how much fight Auburn has.
— Hey, McCalebb for 13. That's new. Now we'll see if Auburn can get rolling after the first down … or, instead, we'll see Oklahoma St. score a touchdown against Texas A&M as an ESPN cutaway misses an entire freaking Auburn play. It's not like they could have ever expected Auburn to play hurry-up, though, right? It's not like that's what the entire freaking offense is based on or anything.
— Todd finds Smith on 3rd-and-3 and he takes it for 21 yards down to the Hog 24. Intriguing.
— 3rd-and-5 after a Tate run and a well-covered shot at Adams in the end zone, and Todd's throw to Smith is nowhere near him. 4th-and-5, and though I kind of think Auburn has to have a touchdown here to stay in the game, I don't blame Chizik for not wanting to risk the psychological damage of getting nothing out of the drive. Out comes Byrum.
— A miss here well and truly ends all doubt, but Foot Lauderdale laughs at your so-called "pressure". 20-3.
— I was deeply worried about how Auburn's kickoff coverage would fare in this game against the Hogs' dangerous Dennis Johnson, and now we (finally) get to see how they do. Will they assuage those worries?
*50 yards later*: No, no they will not.
— The Hogs pick up one first down on the ground, and then here comes the killshot: play-action, Mallett looking for the bomb downfield, receiver one-on-one vs. McFadden. But McFadden times his leap to the millisecond and snatches the ball out of the air before falling into the end zone. Fantastic play. Hard to get too excited just yet–McFadden's hurt again, the ball's on the 1, and it's still 20-3–but that's a huge stop from the Auburn D after the big return. An Auburn score here might actually make things interesting.
— So: Tate for 4. Quick throw to Trott for 4. Huge third-down rollout pass to Zachery picks up 14, and Auburn's out of the hole. Tate for 8. Huge hole. Tate for 1. Tate for 2, first down. C'mon, Auburn.
— Not happening: Todd just does not have it today. Play-action on first down and the line gives him all day–he overshoots Smith, who wasn't exactly open down the seam but had a step. The line then gives him a perfect pocket to step into on 3rd-and-10, and Fannin's open for the first–Todd just misses him, much as he did on the fourth-quarter non-conversion against Tennessee the week before. Auburn punts, and has likely seen their last shot at getting back in this game go by the board.
— This is why Auburn's depth problems matter: they start Arkansas's drive with the second-string defensive line on the field, which includes Dee Ford at defensive end. The Hogs run a sweep that direction, and Ford, who would be on the small side for a strong-side linebacker, gets easily shoved three yards downfield. Adam Herring gets sealed with ease. Bates and Thorpe–who have both been on the field all half–are both slow to react and miss a tackle / can't get off a block, respectively. Ford does eventually track back to tackle … after a 33-yard gain for Smith. If the offense can't make first downs, there's no way out for the defense: their starters are exhausted, the backups can't hack it.
— 2nd-and-10 for Arkansas on the Auburn 25, Bynes makes a terrific play to break up a pass for the Hog TE on a crossing route, and this is the call to get ticked off about it–Bynes times his leap at the ball perfectly and draws a pass interference flag anyway. Even when the earlier flags were technically correct, you could see a call this awful coming a mile away–clearly these guys thoroughly enjoy waving their yellow hankies around on Hog pass plays.
— The Hogs get called for a seriously flagrant hold on Goggans, but even 1st-and-20 isn't enough to save Auburn: two plays later Harry Adams–hey, a backup–has the chance to just plow Hog receiver Reggie Fish out-of-bounds, but instead Fish ducks under the tackle and Adams responds by grabbing his helmet with both hands and pulling it clean off. Facemask, 1st-and-goal, and two plays later it's in the end zone as both Herring and Bates bite on play-action and leave Williams all alone. 27-3. Please, half, just end.
— OK, there's a minute left, maybe Auburn can make something happen. No, nevermind, they can't: three different Hogs converge on Todd for a sack, and even after a Tate screen gets Auburn into 3rd-and-6, Todd misses Fannin on an out that's nearly pick-sixed.
So, on that entirely too-fitting final note for the Auburn offense's first half, the two teams head into the locker room.
*I'd said in the game's immediate aftermatch that the Arkansas player had celebrated this play by grinding his facemask into Fannin's, but on a second viewing that's clearly not the case; the two helmets were just stuck together. That complaint is redacted. Apologies.
Will Herring? Doesn't he play for Seattle now?
"This is because Auburn is an Equal Opportunity Third Down Quarterback Scramble for First Down Provider." – Absolutely priceless. I laughed so hard I had to change shirts.
I don't feel like I can fully put last week's game behind me until I read these! Nice work as usual Jerry.
These are my favorite things to read on blogs all week. I agree with Joe- hopefully this will put last week behind us. Hope the KY recaps have a better ending than this one will.
Jerry, you're a saint. I have no idea how you can stomach writing in such detail about what had to be a very unpleasant game, much less do it in such consistently hilarious and entertaining fashion, but I'm glad you're doing it.
This is the best thing I've read in awhile. Thanks!


text:
Meet Whitney...
no longer feeling alive at work
Whitney hadn't felt valued at work in years, and was longing to make a career change but was intimidated about pretty much all of it:
Our first step in our coaching engagement was to get Whitney centered around her strengths (character strengths and job-related strengths), in tune with what really got her up in the morning and motivated to do great work (a foreign concept at first), and aware of what kind of culture, team and boss were best-suited to her personality and working style. We created a customized map of what a successful workplace looked like for her– how she'd know it when she saw it, and how to seek it out.
One of the most oomphy exercises Whitney completed was a full-on exploration about what kind of life she'd love to reflect back on from the ripe age of 89. She was so mired in her current reality, so concerned what others thought of her… and by answering a host of questions from her 89 year old self, she was able to see what kind of work life (and beyond-work life) she wanted to call her own. That drove a lot of her decisions from that point forward.
Once Whitney gave herself permission to dream a little, she realized she wanted to transition into consulting, with a short-term goal of working at a firm and a medium-term goal of working for herself. (Clarifying her value of freedom and independence really helped seal the deal on this decision.)
Whitney went through a structured process to determine what she wanted (and why), then created a game plan to achieve it. She feels so much more alive and in the driver's seat of her career, which is kind of massively important for the independent type. There's no holding her back now.
Back to the Coaching Page
I'd love to talk about your life. Click below to schedule a call, and while you're at it, sign up for weekly inspiration hand-delivered to your doorstep—or maybe just your inbox.
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redpajama_set_name: RedPajamaCommonCrawl


CAREER DEVELOPMENT HOSTED NBCUNIVERSAL AND A CAMPUS RECRUITER TO INFORM STUDENTS ABOUT INTENRSHIP OPPORTUNITIES AVAILABLE FOR THE 2020 TOKYO OLYMPICS.
On April 2, Sacred Heart and Career Development hosted NBCUniversal, who conducted a lecture and internship recruitment day on campus.
Nicole McArdle, Campus Recruiter and a member of the NBC Olympics team, led the lecture. McArdle covered information regarding the 2020 Tokyo Olympics and the coverage that NBC offers.
"NBCUniversal owns the U.S. media rights on all platforms to all Olympic Games through 2032," said McArdle.
NBC Sports is currently offering internship opportunities for the 2020 Tokyo Olympics. Students enrolled in an undergrad or grad program are eligible to apply.
Positions available during the Olympics are, but not limited to, production assistants, digital production assistants, loggers and runners.
Director of Career Placement, Patricia Moran, saw this seminar as very helpful, and an advantage for students who attended. "So often our students are left to do their own research. There's nothing like having the source come in person and give their full insight," said Moran.
Students in attendance also felt that this was a great networking opportunity, and a chance for them to get some insight into what NBCUniversal and NBC Sports Group are all about.
"It is important to learn about the inner workings of a large company before you apply because it is truly a different environment," said senior Kevin Plant.
Joseph Alicastro, former NBC Producer and current professor and Director of the Masters in Broadcast Journalism & Media Production Program, knows how strong the relationship between Sacred Heart and NBCUniversal is.
McArdle told those in attendance what NBCUniversal and NBC Sports looks for in applicants, and what might help someone land an internship with the company.


text:
Q: Web Crawling Google Scholar - Extracting part of HTML URL to be able crawl the next/previous page I have been tasked with creating a search engine. I understand that I need to create an adaptable URL, I have found the source code that I need to use from the onclick attribute on the button however as this changes from page to page. I need my for loop to be able to read this each time the page changes to be able to update the new URL. I have provided an example of the URL I need to change in square brackets.
I have provided a picture with the highlighted source code I require and part of my unfinished code.
Any help with this would be greatly appreciated.
https://scholar.google.co.uk/citations?view_op=view_org&hl=en&org=9117984065169182779&after_author=c7lwAPTu__8J&astart=20
https://scholar.google.co.uk/citations?view_op=view_org&hl=en&org=9117984065169182779&after_author=[NEW AUTHOR/USER CODE]&astart=[NEW PAGE NUMBER]
def main_page(max_pages):
    page = 0
    newpage = soup.find_all('button', {'onclick': ''})
    while page <= max_pages:
        url = 'https://scholar.google.co.uk/citations?view_op=view_org&hl=en&org=9117984065169182779&after_author='+str(newpage)'&astart='+str(page)
        source_code = requests.get(url)
        plain_text = source_code.text
        soup = BeautifulSoup(plain_text)
        for link in soup.findAll('a', {'href': '/citations?hl=en&user='}):
            href = link.get('href')
            print(href)
        page += 10

main_page(1)

Highlighted source code required

A: You can use a little regular expression and urllib.
from bs4 import BeautifulSoup
import re
from urllib import parse

data = '''
<button onclick="window.location='/citations?view_op\x3dview_org\x26hl\x3den\x26org\x3d9117984065169182779\x26after_author\x3doHpYACHy__8J\x26astart\x3d30'">click me</button>
'''

PATTERN = re.compile(r"^window.location='(.+)'$")

soup = BeautifulSoup(data, 'html.parser')

for button in soup.find_all('button'):
    location = PATTERN.match(button.attrs['onclick']).group(1)
    parseresult = parse.urlparse(location)
    d = parse.parse_qs(parseresult.query)
    print(d['after_author'][0])
    print(d['astart'][0])

redpajama_set_name: RedPajamaStackExchange


After the Saturday morning shift at the post office in Fields Corner, Jim Trabucco was heading back to the home on Neponset Avenue where he's lived since October of 1983, expecting not much in the way of change.
Flat wrong, actually, as flat as what had once been the Frost Mansion, the venerable building across the street from Trabucco's house that until last year had housed Mulry's Funeral Home. The structure was razed on Saturday morning, making way for three two-family units.
The demolition of 223 Neponset Ave. marked the latest in a string of razings and near-razings, alarming preservationists who say the neighborhood's historical makeup is unraveling, and vexing the anti-condo forces who see rising home prices as an inevitable result.
Moreover, the Frost Mansion's demise has politicians pointing fingers at the development team, headed up by Al Prest and Steve Ballou, and accusing them of misleading the neighborhood about the date of demolition.
Elected and city officials said the developers had left them with the impression that the house, constructed in 1803, would still be standing come this past Monday - displeasing to those who sought to preserve it indefinitely, but a half-a-loaf victory for those who recognized that the city's Landmarks Commission policy of a 90-day demolition delay had expired.
In an e-mail to Neponset constituents on Wednesday, May 18, at-large Councillor Stephen J. Murphy wrote, "We have been told that demolition of Frost Mansion will not happen this weekend."
On Monday, after the house had come down, Molly Dunford, the mayor's eastern Dorchester liaison, said, "We were under the impression that they were willing to step back as a gesture of goodwill to the community."
Prest and Ballou told the Rev. Thomas Foley, pastor of St. Ann's, that they hoped to take the house down on May 25, this past Wednesday, but he asked them to schedule it for a day when school wouldn't be in session, Foley said. After it became apparent that the developers were unwilling to wait until school lets out next month, Foley said, "We thought that the agreement was for this coming weekend, the holiday weekend."
City Councillor Maureen Feeney said she sat in a meeting with Ballou, Foley, and St. Ann's School principal Cynthia Duggan on Friday afternoon, and left reassured that at least a week would pass, allowing Foley to alert parishioners, Duggan to notify parents, and Feeney's office to flier the neighborhood.
"I think when someone lies to a priest and a principal, that's unfortunate," Feeney said Tuesday during an interview in her City Hall office. She added, "We were violated as a community."
Neither Prest nor his attorney Joseph Hanley responded to phone calls.
After Feeney moved to put a stop-work order on the property on Monday morning, the developers agreed to mitigation measures like bales of hay to prevent runoff, a secured front gate, and long-term measures like a decorative fence, asphalt removal, and a resurfaced schoolyard.
The events elicited an outburst of anger against the developers, the same ACP Custom Building and Restoration team who tore down a home at 1615 Dorchester Avenue last month, to the consternation of activists who said the Landmarks Commission should have more actively pushed for the early 19th century building's survival.
sneaky, I guess, is the word."
On Monday, Pope's Hill Neighborhood Association president Philip J. Carver sent an e-mail calling for a community boycott of the developers and the realtors who sold them the property, Re/Max's Marquis Group.
The Marquis Group's Craig Galvin declined to comment beyond saying, "It's an unfortunate situation. I've lived in this community for 35 years, and my record of commitment to the neighborhood can never be questioned."
Feeney targeted her ire at Prest and Ballou. "Our issue is with the developers," she said. "I don't know what role the real estate agency would play in the role of developing."
Others fretted about what they call a neighborhood-wide trend. Recently, activists have blocked the demolition of a historic home on Virginia Street in Uphams Corner, and helped persuade the owners of Dolan Funeral Home in Lower Mills not to sell their property to developers who hoped to locate a Walgreen's there.
But other homes, like the 1615 Dot Ave. property, have gone under the knife for the sake of development.
"Other communities get it, I don't know why we can't have developers who feel like that," said Rosanne Foley, chairwoman of the Architectural Preservation Committee of the Dorchester Historical Society and coordinator of the Dorchester Environmental Health Coalition.
Therese Fitzgerald, who grew up in Neponset and recently bought a home on Garner Road, said she was outraged to learn that the e-mail she got from Councillor Murphy was based on bad information.
"I don't oppose development. I don't oppose condos. But I do oppose destroying historic homes," she said. "I'm just afraid that developers will just start thinking they can lie to city councillors and start ripping down houses."
Feeney's office was trying Tuesday to coordinate with the Landmarks Commission an effort to extend the "demo delay" from its current 90 days and, the eastern Dorchester councillor said, "create other mechanisms that allow for more public engagement."
For Trabucco, who last year changed his pre-arranged insurance plan for the eventual passing of his mother to nearby O'Donnell Funeral Home, after a string of relatives had been waked at Mulry's, the building's destruction and the prospect of residences meant new neighbors.
"There's a big condo boom, I guess," he said. "Any place they can put it."


text:
Spanish Painting
Spanische Malerei, Pintura Española 1665 —1920
By Emma Hansen, By Ruth Dangelmeier
From the lavish abundance of the late Baroque court and epoch-making painters like Bartolomé Esteban Murillo and Francisco de Goya, to the appearance of Romanticism and Classicism in the age of the art academies, and the innovative and sometimes scandalous achievements of modernism, Spanish painting offers an extraordinary panorama of outstanding artists, styles, and themes. With around 450 illustrations, Spanish Painting (1665–1920) illuminates the developments from the end of the Golden Age in the 17th century to the early 20th century, and thus serves as a companion to the equally opulent volume Spanish Painting 1200–1665 from Romanesque to the Baroque.
Emma Hansen is an art historian, writer, and editor. She is known through her numerous publications. Art historian Ruth Dangelmaier has worked for many years as a freelance writer and editor. She lives with her family in Cologne.


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The boot is engineered for performance, combining the comfort of DuraShocks with a chiseled-edge rubber lug outsole to deliver superior grip in varied conditions, shedding mud and debris. Durable direct-attach construction is waterproof and flexible, ideal for the longest, busiest days on the job. A waterproof full-grain leather upper and moisture-wicking lining ensure feet stay dry and comfortable. A CarbonMAX nanotechnology safety toe offers lighter-weight, better fit, and a strong structure that meets ASTM standard F2413-11 M I/75 C75 EH.


Liverpool has a rich heritage of quality musical output and Vulture Cult are no exception, despite their relatively short time as a band. Having hit the scene just a year ago the band are rapidly gaining a reputation for engaging audiences with their signature sound and live shows.
Vulture Cult are wasting no time, having proved their worth in the live setting, they are now fixing their attention on reaching as many people as possible through the release of their debut single "Steamrolling" on 6th April.
"It's amazing to see how much we've achieved in just a year, we can't wait for people to hear our first official release – Steamrolling!
We've been playing the song live for a while now and the feedback we've received has been fantastic. We feel it really encapsulates our sound and what we're about musically.


Youth Leadership Congress - Registration Open!
Every summer, Oakdale Electric Cooperative (OEC) offers a fun, educational and unique all-expense paid event that is planned by and for teenagers . . . the Wisconsin Electric Cooperative Association's Youth Leadership Congress (YLC). Students attending YLC also have a chance to compete for post-high school educational scholarships from OEC and the Wisconsin Electric Cooperative Association (WECA).
The annual Youth Leadership Congress is a dynamic three-day event for youth leaders across Wisconsin to develop their leadership skills while learning about the purpose, operation, and scope of cooperative businesses.
Oakdale Electric Cooperative will sponsor up to six students per high school to attend the 2018 YLC at UW-River Falls, July 25-27, 2018.
Student must be entering his/her senior year of high school in the fall 2018 at one of our 12 area high schools: Brookwood, Mauston, Necedah, Nekoosa, New Lisbon, Pittsville, Reedsburg Area, Royall, Sparta, Tomah, Wisconsin Dells, and Wonewoc.
All registration costs are covered by Oakdale Electric Cooperative, including transportation to and from UW-River Falls.
Registration materials are available at each respective high school guidance office beginning in March.
Contact Deana Protz for more information.


text:
CSB Blazers undergo change in 'attitude' with Velasco | Inquirer Sports
NCAA SEASON 89 PREVIEW:
CSB Blazers undergo change in 'attitude' with Velasco
INQUIRER.net / 12:25 PM June 22, 2013
Gabby Velasco. Photo by Noy Morcoso/INQUIRER.net
MANILA, Philippines – Over the course of the offseason, College of St. Benilde underwent a coaching change from Richard del Rosario to Gabby Velasco. The Blazers will also have a different player taking the lead role after their star guard Carlo Lastimosa decided to leave out his final playing year.
But that's just part of the many changes in Benilde as the 89th Season of the NCAA opens Saturday.
"Attitude," said Velasco. "There's going to be a lot of changes there."
The Blazers had the talent for the past couple of years but their 'attitude' as Velasco put it, was always in question.
Lastimosa's presence especially at the offensive end with his ability to break down defenses will be missed but with key holdovers Paolo Taha, Jonathan Grey and the team's emerging leader Mark Romero, that's not what concerns Velasco most as his squad and this year's hosts open up the new season with a same old powerhouse in three-time defending champion San Beda.
"Number one thing that I pride on is the discipline of the team. The system that we're in, we're more conscious now defensively," added Velasco.
Benilde rode heavily on Lastimosa, a proven scorer but reckless at times, last year and Velasco said "I don't think it's going to be the same."
"In terms of production, it will be spread out to everyone. Although, I must also say that one or two players will shine each game but definitely, it's going to be a team effort."
And that one player would be fourth-year forward Romero, who admitted that he's still getting used to being the team's primary option.
Romero had shown at least in the preseason tournament that he can carry much of the team's weight on his shoulders with his versatility on offense.
"Mark (Romero) now has a new role, a bigger role, he's the captain ball and probably he will also lead us in scoring, I hope he will step up to the challenge," said Velasco.
The other? "We also have Paolo (Taha), who had a good year in the [PBA] D-League. Hopefully his experience there, will benefit Benilde."
Taha and Romero are two different players. While Romero's strength is his outside shooting, Taha, with his built, is more of a slasher able to take hits and still convert in the process.
"Expectations are really high this year, especially we're the hosts and I'm hoping that we will be able to live up to the expectations of everyone. Like I said, what we can assure is that this is going to be a different team," Velasco told INQUIRER.net.
"It's a new team that really works harder each day and a team that runs a lot. We have a new team and everyone's excited even the administration and the players. We had a lot of changes, new things in the team. Hopefully it's going to be a good year for Benilde. Considering our standing last year, I think all the teams are a team to beat."
The Blazers finished with just a 5-13 record in their previous stint, just two games ahead of last-place Lyceum.
Usain Bolt wins 100 finals at Jamaica nationals
TAGS: Carlo Lastimosa, College of St. Benilde Blazers, CSB, Gabby Velasco, Jonathan Grey, Mark Romero, NCAA, NCAA season 89, Paolo Taha, Richard Del Rosario, San Beda Red Lions


text:
Foreign Office still giving Stonewall thousands for 'Diversity Champions' scheme
Liz Truss MP took over as Secretary of State for Foreign, Commonwealth and Development Affairs in September.
*UPDATE: Since publication, the Foreign Office has issued a correction to its figures. It initially said it had given Stonewall almost £430,000 over a four-year period. On 17 November 2021, this was updated to almost £975,000 – more than double the original figure.*
The Foreign, Commonwealth and Development Office is still paying thousands to LGBT lobby group Stonewall, despite other Government offices deserting the group's controversial 'Diversity Champions' scheme.
Foreign Secretary Liz Truss – who also holds the Women and Equalities brief – has previously advised government departments to withdraw from the scheme, which tells employers to promote radical gender ideology in the workplace.
Truss made the statement in May and took over as Foreign Secretary in September, but her own department is still on Stonewall's books, having renewed its membership of the 'Diversity Champions' programme in July.
'Conniving'
The Secretary of State is expected to withdraw the department from the scheme when the membership expires next year, as happened when she was head of The Department for International Trade.
The Times reports that the decision to renew the contract was made by senior officials without ministerial approval.
In the past four years the Foreign Office has given the lobby group almost £430,000 to promote LGBT issues abroad.
Officials also invited Stonewall CEO Nancy Kelley to an event last month without Truss's knowledge. Kelley claims that refusing to accept that it is possible to change sex is akin to anti-semitism.
A Whitehall source said: "For FCDO officials to covertly sign off taxpayer funds subsidising a controversial lobby group mired in constant rows is negligent at best and, at worst, conniving." Another said it showed there are a number of officials who consider themselves "fundamentally unaccountable to ministers".
'Unaccountable lobby group'
Stonewall has increasingly come under fire in recent months for its hardline promotion of radical gender ideology, and its pervasive influence on public bodies and other institutions.
Last month, BBC journalists Stephen Nolan and David Thompson revealed the widespread influence of the LGBT lobby group on national governments and institutions in their podcast Nolan Investigates: Stonewall.
During the series, Nolan observed: "We have spent months investigating the public bodies who have a relationship with Stonewall. And we've found examples, where government is essentially paying Stonewall to lobby it. Yes. You've heard that right. I'll say it again. Lobbyists being paid, by the people they are lobbying, to lobby."
He asked: "How worrying is it, that there is an unaccountable lobby group, partly funded by you, the public, which has unparalleled access to your Government, to your employer, to your police force, to your BBC?"
'Flood' of public bodies exit Stonewall scheme
Lawyer: 'Stonewall misleading universities over equality law'
Misleading trans schools guidance scrapped by equalities watchdog
Public bodies paying thousands to join Stonewall's pro-LGBT scheme
Foreign, Commonwealth and Development Office: Stonewall (parliament.uk, 17 November 2021)
Foreign Office is still paying Stonewall thousands of pounds months after Liz Truss urged ministries to pull out of diversity scheme (dailymail.co.uk, 8 November 2021)
Ministers kept in dark on Stonewall diversity scheme (thetimes.co.uk, 9 November 2021)
'The Bible determines our doctrine'
BBC gay wedding service 'out of proportion' with reality
Abortion and same-sex marriage 'railroaded through' in Northern Ireland


460. Classification and Regression Training - The caret packages contain functions for tuning predictive models, pre-processing, variable importance and other tools related to machine learning and pattern recognition. Parallel processing versions of the main package are also included.
461. Probability - This package is for performing elementary probability on finite sample spaces, represented by data frames or lists. Functionality includes setting up sample spaces, set algebra, probability and conditional probability, characteristic functions, and more.
462. PhyloConductor - PhyloConductor aims to form a collection of R packages for phylogenetic, comparative, and other evolutionary analysis that is coherent and user-accessible. Initially we focus on comparative phylogenetic methods for the analysis of trait evolution.
463. Interface to use SIMPLACE from R - Package simplace is an interface to the crop modelling framwork SIMPLACE (www.simplace.net). It provides high level functions to run simulations and transform the output into R objects.
464. Monte Carlo IBD Matrix Estimation - Flexible Monte Carlo Identity-By-Descent (IBD) Matrix Estimation with Within-Line Segregation for Use of Quantitative Trait Loci (QTL) Detection in F2 Intercross Designs.
465. DirichletReg - Dirichlet Regression - This project implements Dirichlet regression models for the analysis of compositional data. Starting with the basic fit routines, new functions (model selection, graphics, etc.) will be added and tested here, before being submitted to CRAN.
466. SensoMineR - SensoMineR is dedicated to sensory data analysis. It tackles the following problems: characterizing products, assessing panel performances, relating sensory and instrumental data, mapping consumers' preferences, napping data, categorizing products.
468. R Point and Figure Library - The R Point and Figure Library is an open source tool-set to create and analyze Point & Figure Charts for given time series or data frame objects.
470. Hybrid Monte Carlo - Hybrid Monte Carlo (HybridMC): sampling from continuous joint distributions using Hamiltonian (or Hybrid) Monte Carlo techniques.
473. Classification methods and visualization - Miscellaneous functions for classification and visualization.
474. RHmm - Simulations and estimations of discrete, univariate or multivariate gaussian, mixture of univariate or multivariate gaussian hidden Markov models.
475. FinTS - To create a companion package for Ruey Tsay (2005) Analysis of Financial Time Series, 2nd ed. (Wiley).
476. matchingMarkets - This package implements a structural estimator to correct for the sample selection bias from observed outcomes in matching markets. It also contains R code for matching algorithms for college admissions, stable roommates and house allocation problems.
477. msap - The package msap provides a easy way to analyse MSAP (Methylation-Sensible Amplified Polymorphism) data in order to asses epigenetic and genetic differences between groups of samples.
478. Composite Likelihood for Random Fields - Composite-Likelihood based methods for Random Fields.
479. Circular Statistics - This is the circular package build over the R port of the CircStats package by Ulric Lund from 'Topics in circular Statistics' (2001) S. Rao Jammalamadaka and A. SenGupta, World Scientific.


text:
Q: Scraping for href links Trying to collect the specific link on this page with the correct keywords, so far I have:
from bs4 import BeautifulSoup
import random
url = 'http://www.thenextdoor.fr/en/4_adidas-originals'
r = requests.get(url)
soup = BeautifulSoup(r.text, 'lxml')
raw = soup.findAll('a', {'class':'add_to_compare'})
links = raw['href']
keyword1 = 'adidas'
keyword2 = 'thenextdoor'
keyword3 = 'uncaged'
for link in links:
    text = link.text
    if keyword1 in text and keyword2 in text and keyword3 in text:

Im trying to extract this link

A: You can check if all are present with all() and if either 1 is present with any()
from bs4 import BeautifulSoup
import requests

res = requests.get("http://www.thenextdoor.fr/en/4_adidas-originals").content
soup = BeautifulSoup(res)

atags = soup.find_all('a', {'class':'add_to_compare'})
links = [atag['href'] for atag in atags]
keywords = ['adidas', 'thenextdoor', 'Uncaged']

for link in links:
    if all(keyword in link for keyword in keywords):
        print link

Output:
http://www.thenextdoor.fr/en/clothing/2042-adidas-originals-Ultraboost-Uncaged-2303002052017.html
http://www.thenextdoor.fr/en/clothing/2042-adidas-originals-Ultraboost-Uncaged-2303002052017.html

A: Or, you can do it in one go using a function as an href attribute value for find_all():
keywords = ['adidas', 'thenextdoor', 'Uncaged']
links = soup.find_all('a',
                      class_='add_to_compare',
                      href=lambda href: all(keyword in href for keyword in keywords))
for link in links:
    print(link["href"])


text:
Q: Ember-Cli-Mirage 404 Just followed the documentation but every time I navigate or call to the url, it returns 404 for me
// app/mirage/config.js
export default function() {

  this.get('/api/users', function() {
    return {
      users: [
        {id: 1, name: 'Zelda'},
        {id: 2, name: 'Link'},
        {id: 3, name: 'Epona'},
      ]
    }
  });

}

Uncaught UnrecognizedURLError: /api/users
Thanks for your help.

A: Navigating directly to that URL in your browser will not follow the mirage pipeline. Rather, when your ember application would have queried the end points you have configured, mirage will send mocked data instead. Therefore you need to implement something that will call your endpoint from within your Ember app.


As part of our ongoing effort to strengthen and modernize our PB Shipping APIs system infrastructure, we will be performing system maintenance in our PB Shipping APIs PRODUCTION environment on Saturday October 13th at 8:00 PM ET for approximately 20 minutes.
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text:
Q: Earliest story to mention the different surface gravity on the Moon What was the first science fiction story to mention that the Moon has a lower surface gravity than the Earth?
I'm sure that was mentioned many times in science fiction before the Space Age began in 1957.

*

*Did the movie Destination Moon (1950) mention the lower lunar surface gravity?

*What about Heinlein's Rocket Ship Galileo (1947)?

*What about Maza of the Moon (1929,1930) by Otis Adelbert Kline?

*What about the children's fantasy Dr. Doolittle on the Moon (1928) by Hugh Lofting?

*What about The Moon Maid (1926) by Edgar Rice Burroughs, who did mention the lower surface gravity of Mars in A Princess of Mars (1912).

*What about The First men in the Moon (1900,1901) by H.G. Wells?

*What about From the Earth to the Moon (1865) by Jules Verne?

A: Here is a partial answer to my own question:
Zeiss Ikon's answer says that there was lower gravity on the Moon in Heinlein's Have Spacesuit, Will Travel (1958).
In the movie, Destination Moon (August, 1950) (transcript):

Doc, I'll never get use to this.
This must weigh 500 or 600 pounds!
On Earth it does. Gravity here
is about 1/6 as much.
That means things weigh 1/6 as much.
I know it, but I can't believe it.

By coincidence the comment of  marecllothearcane says:

Destination Moon (the Tintin comic), published 30 March 1950, shows lower surface gravity on the moon.

..............................................................................
Added 11-13-*19.  The children's novel The Voyage of the Luna 1 (1948), by David Cragie (Dorothy Glover), Part Two, Chapter IX, "The New World", page 176:

The force of gravity on the moon being only a sixth as great as on the earth, they could jump six times as high as they were accustomed to, and they were to discover later that they could climb six times as high without getting tired; but as this stage of their adventure it was still part of the great mystery.

..................................................................................
The comment of Drewbenn about The Moon Maid (1926):

The Moon Maid, available through Project Gutenberg, is easy to check, and the characters are well aware of it: "...the natural effects of the lesser gravity of the Moon. We have discussed the matter upon many occasions... yet when we faced the actual condition we gave it no consideration whatsoever. Of course, it's in the context of jumping over a river. So you can remove everything in your question that comes after that

H.G. Wells' The First men in the Moon (1900,1901) Chapter 9, "Prospecting Begins", at Project Gutenberg, says:

As he stepped forward he was refracted grotesquely by the edge of the glass. He stood for a moment looking this way and that. Then he drew himself together and leapt.
The glass distorted everything, but it seemed to me even then to be an extremely big leap. He had at one bound become remote. He seemed twenty or thirty feet off. He was standing high upon a rocky mass and gesticulating back to me. Perhaps he was shouting—but the sound did not reach me. But how the deuce had he done this? I felt like a man who has just seen a new conjuring trick.
In a puzzled state of mind I too dropped through the manhole. I stood up. Just in front of me the snowdrift had fallen away and made a sort of ditch. I made a step and jumped.
I found myself flying through the air, saw the rock on which he stood coming to meet me, clutched it and clung in a state of infinite amazement.
I gasped a painful laugh. I was tremendously confused. Cavor bent down and shouted in piping tones for me to be careful.
I had forgotten that on the moon, with only an eighth part of the earth's mass and a quarter of its diameter, my weight was barely a sixth what it was on earth. But now that fact insisted on being remembered.

So the search should be for examples published in or before 1900.
[Added 08-04-2019.  Edgar Allen Poe's The Unparalleled Adventure of One Hans Pfaall, published in 1835, is mentioned as a possibility by Sean Condon in his answer, although he was a little uncertain how to interpret Poe's words.
I known of another Poe work, published years later, that is a bit more specific about the lunar gravity, "Mellonta Tauta" published in Godey's Ladys's Book, February, 1849, and allegedly written in 2848, which includes this paragraph:

April 7.—Continued last night our astronomical amusements. Had a fine view of the five Neptunian asteroids, and watched with much interest the putting up of a huge impost on a couple of lintels in the new temple at Daphnis in the moon. It was amusing to think that creatures so diminutive as the lunarians, and bearing so little resemblance to humanity, yet evinced a mechanical ingenuity so much superior to our own. One finds it difficult, too, to conceive the vast masses which these people handle so easily, to be as light as our own reason tells us they actually are.

The last sentence seems to be referring to the lower surface gravity on the Moon.
Of course that may not matter since user14111's answer mentions two earlier stories that have people jumping long distances in the lighter lunar gravity.
They are A Voyage to the Moon, by George Tucker (1827) and The Man in the Moone, by Bishop Francis Godwin (1638).  Yes, 1638.  As user14111 says, Godwin exaggerated the difference in surface gravity but can be forgiven since he wrote before Isaac Newton was born.
It is possible that user14111 found the earliest example, but not entirely certain.
One good candidate to be the earliest work of science fiction to mention the lower surface gravity of the Moon would be Johannes Kepler's (1571-1630) Somnium.

Somnium (Latin for "The Dream") is a novel written in 1608, in Latin, by Johannes Kepler. The narrative would not be published until 1634 by Kepler's son, Ludwig Kepler. In the narrative, an Icelandic boy and his witch mother learn of an island named Levania (our Moon) from a daemon. Somnium presents a detailed imaginative description of how the Earth might look when viewed from the Moon, and is considered the first serious scientific treatise on lunar astronomy. Carl Sagan and Isaac Asimov have referred to it as one of the first works of science fiction.[1]
Somnium began as a student dissertation in which Kepler defended the Copernican doctrine of the motion of the Earth, suggesting that an observer on the Moon would find the planet's movements as clearly visible as the Moon's activity is to the Earth's inhabitants. Nearly 20 years later, Kepler added the dream framework, and after another decade, he drafted a series of explanatory notes reflecting upon his turbulent career and the stages of his intellectual development. The book was edited by Ludwig Kepler and Jacob Bartsch, after Kepler's death in 1630.

Since Somnium was written in stages, it may be uncertain precisely when various details about the Moon were first included, but it was first published four years before Godwin's book.
So there is a factual question of whether Somnium mentions lower surface gravity on the Moon, and a more subjective question whether one considers Somnium to be an early work of science fiction.
If the answer to both questions is yes, then there should be only a few earlier stories of voyages to the Moon, back to Lucien's True History, to consider as possible candidates.]

A: A plausible but confusing case could be made for Edgar Allan Poe's 'The Unparalleled Adventure of one Hans Pfaall' published in 1835.
The work describes an adventurer travelling to the moon using a customised hot air balloon. Poe directly considers the variable gravity of the moon leaving it as an open issue (from the perspective of the explorer) whether it differs from Earth:

I could not be positive either about the gravitation or the
  atmospheric density of the moon.

Reading between the lines his discussion of the 'atmosphere' of the moon reveals assumptions about its gravity:

In the earliest stage of my speculations upon the possibility of a
  passage to the moon, the existence, in its vicinity, of an atmosphere
  dense in proportion to the bulk of the planet, had entered largely
  into my calculations.

Since the formation of an atmosphere relies heavily on the gravitation of a body this implies that Poe was assuming that the smaller size of the moon would lead to weaker gravity than on Earth.
The archaic and unscientific language and less plausible theories elsewhere in the script (a weak ethereal solar atmosphere extending beyond Venus for example) make the text hard to interpret but it is certainly a very early example if it applies!

A: I can give a worst case example: the persistent reduced gravity was part of how Kip Crawford decided he was, in fact, on the Moon after being kidnapped in Have Space Suit, Will Travel (Heinlein, 1958).  Heinlein got Pluto's surface gravity wrong later in the same book, but at that time, Pluto was no more than a dot in the best telescopes that existed, so no one was really sure of its size or composition (never mind thinking it had four moons).

A: 1827: A Voyage to the Moon, a novel by George Tucker, available at Project Gutenberg.

All bodies are much lighter on the moon than on the earth; by reason of which circumstance, as has been mentioned, the inhabitants are more active, and experience much less fatigue in ascending their precipitous mountains. I was astonished at first at this seeming increase in my muscular powers; when, on passing along a street in Alamatua, soon after my arrival, and meeting a dog, which I thought to be mad, I proposed to run out of his way, and in leaping over a gutter, I fairly bounded across the street. I measured the distance the next day, and found it to be twenty-seven feet five inches; and afterwards frequently saw the school-boys, when engaged in athletic exercises, make running leaps of between thirty and forty feet, backwards and forwards. Another consequence of the diminished gravity here is, that both men and animals carry much greater burdens than on the earth.

1638: The Man in the Moone, a novel by Bishop Francis Godwin, available at Project Gutenberg.

The manner of our Travel to the Palace of Pylonas was more strange and incredible than any thing we have related, for at our first setting forth there were delivered to each of us two Feather Fans, like those our Ladies in Spain cool themselves with in Summer: You must understand, that the Globe of the Moon has likewise an attractive Power, yet so much weaker than the Earth, that if a Man do but spring upward with all his Strength, as Dancers do in shewing their Tricks, he will be able to mount fifty or sixty Foot high; and being then above all Attraction from the Moon's Earth, he falls down no more, but by the Help of these Fans, as with Wings, they convey themselves in the Air in a short Space, (though not quite so swift as Birds) whither they please. In two hours Time (as I could guess) by the Help of these Fans, we were carried through the Air those five Leagues, in all about sixty Persons.

If Bishop Godwin's gravity is not quite correct, please cut him some slack, seeing as he wrote this story before Isaac Newton was born.


text:
Because it sustains huge popularity, the "Genealogy at a Glance" series continues to expand its choice of titles. The latest addition focuses on one of the thirteen original colonies. South Carolina Genealogy Research, compiled by Michael A. Ports, provides an overview of basic information that researchers need to know in order to navigate successfully through the various genealogical resources of the Palmetto State.
Because the study of genealogy is closely connected to history, Ports supplies background data about the state's early organization and settlement. He explains that in 1663, King Charles II granted the charter for the Province of Carolina, which was divided into the royal colonies of North Carolina and South Carolina in 1719. Prior to about 1700, South Carolina's population was evenly divided between persons of English and French origins. From 1700 to 1770, new settlers--mainly from the British Isles, Bermuda, and Barbados--arrived and the number of plantations around Charleston and the surrounding region increased.
Migration into the Carolina backcountry was slow until the mid-1750s, when settlers of British and Germanic descent traveled there via the Great Wagon Road. Between 1790 and 1820, the state's population more than doubled and continued to grow throughout the following years. Ports also furnishes data on South Carolina's role in the Revolutionary and Civil wars.
Approximately half of the guide pertains to the history and complexity of several traditional state and county genealogical materials. For instance, Ports briefly explains that the counties of Granville, Colleton, Berkeley, and Craven did not keep any records prior to 1785. In that year, several new counties, including Camden and Ninety Six, were created. Between 1800 and 1868, counties were called districts.
Concerning the subject of vital records, he says that statewide registration of births and deaths began in 1915, although some places, such as Charleston, started recording them as early as 1821. Kept by the county probate judge, marriage licenses were not required until 1911. The original loose probate papers no longer exist, but recorded copies survive.
Under the topic of military records, the compiler touches on materials concerning the Revolutionary, War of 1812, the Mexican War, and the Civil War. Most of the few surviving colonial records have been published.
He devotes the largest space to land records, including information about the land grant process. In addition, he tells about supplementary sources, such as tax lists and county court records. For these main record groups, Ports furnishes titles of publications and/or websites for further investigation. He also supplies useful miscellaneous online resources and the names, mailing addresses, phone numbers, and websites of some of South Carolina's major repositories.
Following the standard format of the series, Ports condenses into four laminated pages a huge amount of information into its key elements. South Carolina Genealogy Research is a handy, compact guide that will be useful to family researchers whose roots extend back to the Palmetto State. Since Christmas is fast approaching, a copy may be the perfect gift for individuals interested in tracing their roots in that area of the South.
To the guide's price of $9.95, buyers should add the cost for postage and handling charges. For U. S. postal mail, the cost is $5.50 for one copy and $2.50 for each additional copy; for FedEx or UPS Ground Service, the cost is $8.50 for one copy and $3.50 for each additional copy. The guide (item order 4671) may be purchased by check, money order, MasterCard, or Visa from Genealogical Publishing Company, 3600 Clipper Mill Rd., Suite 260, Baltimore, MD 21211-1953. For phone orders, call toll free 1-800-296-6687; fax 1-410-752-8492; website www.genealogical.com.


text:
BARCA!
Big game last night, anticipation, as is all too often the case, was much better than the match sadly, but still, Ronaldinho came in second half…and the crowd went wild! No Messi sadly, only 7 starters, Marquez was there, Omar Bravo for the Chivas…ended up as a tie 1-1, some good shots on goal, one of them off the crossbar, but a pretty defensive game alltogether though Barca dominated. Some drama around the Barca goal I found later, supposedly should have been offsides, but who could tell where we were?? The crowd really deserved better because it was an amazing event. Since most of the male population of Jalisco currently lives in LA you can imagine the Chivas fervour and the crowd was amazing, the distractions on the whole were better than the match, and here they are in order of appearance…first though the view from where we were sitting
You can see that forgiveness is necessary for a lack of the play by play excitement that might have been had I been in a box seat. I'll try and make richer friends! So, focus on what I did see…ie distractions:
1. Coors light…the only alcoholic (if you can call it alcoholic) beverage served at the event, a tragic mockery of beer on sale a pitiful 2 glasses at a time. Luckily I forgot to eat something before so I just made it to the proper feel-good haze required for a football match.
2. A small child sat behind who was cute enough, but thought it great fun to hit my back as I was watching
3. The wave, made the rounds several times during the frequent dull moments
4. Some idiot female dancing and threatening to take of her top (she never did to great general disappointment)…she had my entire section on their feet staring to our left and blocking my view. I suppose if you don't have your own breasts a view of someone elses is pretty exciting, especially for all of the 10 year olds in the crowd who might have never seen them…5 policeman converged…the police had a mighty presence at the game, this isn't quite in order but here they are escorting the refs off the field from the first MLS game (it was a doubleheader), mildly amusing as no one really cared about the game or the refs…
6. An unknown man to our left in a very large sombrero somehow incited the ire of the crowd which commenced a massive food fight and the throwing of cups of beer and water…didn't get a good shot of that sadly, but the police were forced to intervene a second time.
7. Sprinklers!! Oh yes, someone forgot to turn of the automatic timer so the sprinklers came on in the middle of the game, just on our end of the field and sadly play was far away as Barca rushed the Chivas goal so no one got wet…All of the action happened once Ronaldinho was in and hell for me because it all happened on the other end of the field mostly…
8. Fireworks! How fans got fireworks in I do not know, but they were quite lovely against the backdrop of downtown…
9. Smoke bombs? Is that what they were? I don't know, but there was an entire section of mad chivas fans complete with red and white streamers and as far as I can tell no one there sat down for the duration of the two games, and they had drums…The smoke effects were quite impressive however, I imagine the police intervened yet again, but could see nothing!
And so there you have it! A great time had by one and all I believe! Especially when the Chivas scored to tie the game, a lovely header in the last minutes.
2:35 – 0 Comments – 0 Kudos –
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text:
July-September 2021
Page Nos. 235-348
Online since Tuesday, September 7, 2021
Microbiological profile, antibiogram, and risk factors of patients with diabetic foot infections: A systemic metaanalysis p. 235
Fatima H Kadhim, Suhad Hadi Mohammed
DOI:10.4103/bbrj.bbrj_85_21
Background: Diabetic foot ulcer (DFU) is considered a major social and economic problem, and it is also known as a leading cause of morbidity and mortality. Patients with DFUs frequently require amputation of the lower limbs, and in more than half of the cases, infection is the predominant factor. The aim of this systemic review is to highlight the risk factors such as age and gender associated with DFU infections, whether the infection is caused by single bacteria or polymicrobial infection and what is the most prevalent bacteria and their susceptibility pattern to currently used antibiotics. Methods: Three databases were searched from December 2020 to February 2021 including PubMed, Hinari, and Google Scholar. A total of 12 articles were included in the current meta-analysis. Results: Higher frequency of DFU in males than in females and maximum number of DFU mostly occur within the age group 40–60 years was reported. Monomicrobial infections in DFU were higher than monomicrobial infection. Escherichia coli, Pseudomonas, and Staphylococcus aureus were the most prominent microorganism. The higher grades of the DFUs were infected with more than one organism. High resistance rates of the isolated bacteria to the most commonly used antibiotics were documented and there were alarming growing resistance rate to Carbapenems which were considered the most effective Antibiotics nowadays. Conclusions: DFU infections are one of the major social and economic problems. There is an urgent need for continuous antibiotic sensitivity testing for the isolated bacteria to choose the appropriate antibiotics during the management and limit the spreading of multidrug-resistant bacteria and reduce the burden of health-care cost.
A review on biomarkers in clinical osteoporosis - Significance of hydroxyproline p. 245
Soumya Adugani, Gurupadayya Bannimath, Purushothama Sastry
Osteoporosis is a chronic disorder in both men and women, where it decreases the bone quality and quantity, which may lead to a fall in bone mass density. It mostly occurs because of reduced peak bone mass or excessive formation or resorption during bone remodeling. Various degradation products of bone collagen are pyridinoline (Pyr), deoxypyridinoline, N-terminal telopeptides, and hydroxyproline (Hyp), which are excreted in the urine. Among that, Hyp is a crucial biomarker used to correlate osteoporosis condition. An overview of all the biomarkers and the signed note of Hyp with different analytical methods are provided in the current piece of work. To quantify amounts in biological samples, various methods have been developed for Hyp analysis, such as the colorimetric technique, gas chromatography, gas chromatography-mass spectrometry, and widely used high-performance liquid chromatography tests to detect the concentration of Hyp in different matrices. This review states the importance of biomarkers and Hyp's significance for detecting osteoporosis, clinical manifestation, and different analytical methods for Hyp. The study indicates that hydroxyproline is a unique biomarker used to detect osteoporosis. It is also showing the clinical manifestation of osteoporosis and discussed different analytical methods for hydroxyproline.
Nanocurcumin: Potential natural alkaloid against oral squamous cell carcinoma p. 252
Rachael Jahander Khodabux, Venkatachalam Deepa Parvathi, Thamizhchelvan Harikrishnan
DOI:10.4103/bbrj.bbrj_102_21
Oral cancer has high mortality and morbidity. The traditional treatment of oral squamous cell carcinoma (OSCC) is often a combination of surgery, chemotherapy, and radiation. Curcumin is a natural alkaloid used for centuries against various ailments including cancer. Nanotechnology has its profound application in the diagnosis/prognosis and for therapeutics in cancer. In therapeutics, nanotechnology can convey site-specific delivery of pharmaceutical agents by conferring new properties to the agents and only targeting the drugs to the tumor site, thus reducing systemic toxicity. The encapsulation of curcumin into polymeric nanoparticles seems to be beneficial, since it allows the administration of curcumin hydrophobic drug as an aqueous dispersion. Curcumin reports to inhibit cell proliferation and apoptosis in head-and-neck squamous cell carcinoma and suppresses OSCC cell growth. Most research studies conducted have focused on the anticancer properties of bulk curcumin and its application in adjuvant therapy. The challenge that bulk curcumin poses in terms of its limited uptake and permeability into tissues cannot be ruled out. The possible efficacy of nanocurcumin its effects on OSCC cell line has not been explored adequately. This study aims to review and assess the efficacy of nanocurcumin and its potential as a natural alkaloid against OSCC.
Contrasting role of autophagy in different types of cancer: A review toward biomarkers and therapeutic improvement p. 260
Pallab Chakraborty
Autophagy, the major cellular pathway, is known not only for the degradation and recovering in mammalian cells but also it maintains the cellular energy homeostasis and produces the building blocks. However, if the process starts destroying the essential ones other than the bad proteins, then the normal cellular control will be lost, and here, we see similar kinds of phenomena in cancer. It has been reported by previous papers related to this field that the novel pathway has paradoxical role in cancer, as it acts as both tumor promoter and suppressor. Therefore, autophagy could provide new resources for the improvement of antitumor drugs in near future. Here, in this review, we will know about the autophagy process in brief. We will also try to understand the contrasting role of autophagy in different cancers types, its significance as prognostic markers and its therapeutic implication for cancer treatment in the near future.
Mucormycosis "Black Fungus" new challenge associated with COVID 19 p. 267
Falah Hasan Obayes Al-Khikani
Corona virus-19 disease (COVID-19), caused by SARS-Cov-2. What was initially considered to be another worldwide flu epidemic mostly affecting the respiratory system has now emerged as a multi-organ disease, the most common extra-pulmonary involved organs include the blood vessels, eyes, heart, gastrointestinal tract, liver, skin, and kidneys. A growing number of case reports and series describe opportunistic fungal infections in COVID-19 patients. Co-morbidities such as diabetes mellitus, coupled with immune dysfunction and use of steroids, are hypothesized as the main causes. More recently, many cases of mucormycosis "black fungus" have been reported, particularly in Asian countries such as India. Mucormycosis is a rare angio-invasive illness caused by the fungi Mucorales, which is often seen in immunecompromised patients. Rhino-orbitocerebral, cutaneous, disseminated, gastrointestinal, and pulmonary forms of this unusual fungal infection exist. COVID-19 and Mucormycosis, Risks factors associated with Mucormycosis in COVID 19, Immune system response to mucormycosis, fungal pneumonias can resemble COVID-19, as well as prevention of these fungal will be discussed in this review.
Oral microbiota in children with acute tonsillitis p. 272
Shokhida Tolkunovna Turdieva, Gulmira Ramzitdinovna Nasirova
Background: More recently, the human oral microbiota has attracted attention in epidemiological research on health and disease. Against this background, changes in the oral microbiota in acute diseases of the upper respiratory tract are of interest in modern pediatrics and epidemiology. The composition of the bacterial flora is one of the main premorbid backgrounds that determine the clinical course of acute tonsillitis in children. However, the prevalence of bacterial flora and its impact on the clinical course of patients with acute diseases remains unclear. Aims: The aims are to study the state of the oral cavity microbiota in children with acute tonsillitis. Methods: The microbiota of the oral cavity was studied in 221 children aged 3–14 years with acute tonsillitis. General clinical examinations and pharyngoscopy were performed. Bacteriological examination of the oral microbiota was carried out according to the standard method. Results: Colonization by the following was most frequently observed in patients: Staphylococcus aureus (42.2%), Streptococcus pneumoniae (32.0%), Haemophilus influenzae (24.2%), Haemophilus parainfluenzae (18.8%), Streptococcus anginosus (10.9%), Moraxella catarrhalis (9.4%), Streptococcus dysgalactiae ssp. equisimilis (8.6%), and Streptococcus agalactiae (3.1%), which most often occurred as symbionts. Conclusions: In children with acute tonsillitis, colonization of the tonsils by pathogenic bacterial flora increases, changing the composition of the oral microbiota. The most common causes of oral microbiota imbalance in children with acute tonsillitis were S. aureus, Streptococcus pyogenes, and H. influenzae, with varying relative proportions.
The effect of three acid-resistant isolated proteins from Lactobacillus casei on lipid and carbohydrate metabolism pathway-related genes: An In vitro study p. 276
Golgis Karimi, Mina Saadat, Shivasadat Gheflat, Bahram Kazemi, Mojgan Bandehpour
Background: The role of Lactobacillus casei on human health is well documented. However, little is known about their protein effects on food digestion. Therefore, in the present study, we aimed to investigate the efficacy of three proteins of L. casei on lipid and carbohydrate digestion that was identified at acidic pH in our previous study. Methods: Chaperonin (Ch), metal-dependent hydrolase (HYD), and lysozyme (LYS) proteins that were expressed by cultivated L. casei at pH 5 were extracted. HepG2 cell line was used to elucidate the effect of the considered three proteins on gene expression related to fat and glucose metabolism. The target genes were determined by Kyoto Encyclopedia of Genes and Genomes pathway analysis and extracted proteins were transfected into HepG2 cells. After 48 and 120 h, the mRNA expression of the following genes was analyzed using real-time polymerase chain reaction, insulin receptor substrate 2, (IRS-2), Protein kinase Bβ (AKT2), insulin-like growth factor 1, angiopoietin-like 4 (Angptl-4), and lipoprotein lipase (LPL). Results: The expression of all of the genes was significantly increased in comparison to control under the effect of Ch and metal-dependent HYDs after 48 h of culture. By increasing the duration of transfection from 48 h to 120 h, the expression of Angptl-4 from Ch and metal-dependent HYDs was reduced significantly, whereas the expression of LPL and Angptl-4 genes after 5 days was significantly increased in LYS compared to the last 3 days. Conclusions: L. casei secrets acidic proteins such as Ch, metal-dependent HYD, and LYS in bloodstream are involved in the digestion of carbohydrates and fats in the liver.
Inflammatory response, plasma albumin, creatinine, alanine aminotransferase, and packed cell volume in relationship with the degree of anemia and gestational age in HbAA anemic pregnant women p. 281
Mathew Folaranmi Olaniyan, Musa Abidemi Muhibi, Kehinde Abiola Babatunde
Background: Anemia in pregnancy which may be mild, moderate, or severe is a common physiological disorder that can lead to poor pregnancy outcome which may be primary or secondary to problems associated with hepatic, renal, and immune system which may be indicated by alterations in packed cell volume (PCV), alanine transaminase, albumin, tumor necrosis factor-alpha (TNF-α), and creatinine. This work is, therefore, designed to determine inflammatory response, plasma albumin, creatinine, alanine aminotransferase (ALT), and PCV in relationship with the degree of anemia and gestational age in anemic pregnant women. Methods: Two hundred (200) HbAA anemic pregnant women and 100 nonanemic pregnant women were recruited as test and control subjects, respectively. All subjects were negative to HIV-Ag-Ab, acid-fast bacillus (AFB)-Ziehl–Neelsen, Plasmodium, anti-hepatitis C virus (HCV), and hepatitis B envelope antigen (HBeAg) tests. HIV-Ag-Ab, TNF-α, anti-HCV, and HBeAg were determined by enzyme-linked immunosorbent assay; AFB by Ziehl–Neelsen staining; Plasmodium by thick-film Giemsa staining; hemoglobin types by hemoglobin electrophoresis; albumin, creatinine, and ALT by auto-chemistry analysis using COBAS C11; and PCV by microhematocrit tube method. Results: Eighteen percent (36) of the anemic pregnant women had severe anemia whereas 82% (164) had moderate anemia. The results obtained showed a significant increase in the plasma value of TNF-α and a decrease in the PCV in anemic pregnant women compared with the results obtained in the nonanemic pregnant women (P < 0.05). There was a significant increase in plasma TNF-α in severe anemia compared with the anemic pregnant women with moderate anemia (P < 0.05). Conclusions: This work revealed a significant increase in plasma TNF-α and a decrease in PCV in anemic pregnant women which was more intense in anemic pregnant women with severe anemia while the pattern of anemia showed that 18% (36) of the anemic pregnant women had severe anemia whereas 82% (164) had moderate anemia.
Identification of potential common molecular factors of pancreatic cancer and diabetes mellitus using microarray data analysis combined with bioinformatics techniques and experimental validation p. 286
Sima Kalantari, Akram Pourshams, Raheleh Roudi, Hakimeh Zali, Mojgan Bandehpour, Abolfazl Kalantari, Reza Ghanbari, Alberto D'Angelo, Bahram Kazemi, Zahra Madjd
Background and Aim: Detection of early-stage pancreatic cancer (PaC) patients can decrease the mortality rate through surgical resection thanks to a screening approach of high-risk and asymptomatic individuals. Up to 80% of PaC patients are either hyperglycemic or diabetic at the time of diagnosis. Diabetes mellitus (DM) identification as an early manifestation of PaC may lead to detection of this malignancy at early and presymptomatic stages. Therefore, the current study aims to identify common molecular factors between DM and PaC to shed light on a potential screening for DM as a diagnostic approach for PaC. Methods: The study was divided into three steps including dataset selection and identification of key genes, quantitative real-time polymerase chain reaction (qRT-PCR) to validate these genes, and enrichment analysis of their target genes. Results: Using GEO2R analysis, conducted on microarray dataset (GSE15932), SPI1 and Yin Yang 1 (YY1) genes were found to be expressed in peripheral blood mononuclear cells of PaC, DM, and PaC + DM patients. Moreover, qRT-PCR results in validation of microarray data showed a significant increment of these two genes among all patient groups. Furthermore, enrichment analyses of SPI1 and YY1 target genes revealed that they are mainly expressed in hematopoietic cells and associated with immune responses as well as immune signaling pathways. Discussion: We speculate that this study on SPI1 and YY1 genes and their targets can result in a successful strategy to investigate diabetes as a screening step for better management of PaC screening using standard serologic tests.
Hematological and biochemical effects of Toxoplasma gondii, Entamoeba histolytica, and Schistosoma infection among Hepatitis C virus patients from Menoufia Province, Egypt p. 295
Hany M Ibrahim, Azza H Mohamed, Hend S Mabrook
Background: Hepatitis C virus (HCV) is highly distributed in Egypt. Moreover, parasitic diseases such as schistosomiasis, toxoplasmosis, or amebiasis are frequent in Egypt. Dual infections of HCV and each of these parasitic diseases are possible and associated with bad clinical consequences. The present study was done to monitor the clinical, biochemical, and hematological changes in Toxoplasma gondii, Entamoeba histolytica, and/or Schistosoma co-infection in the HCV-infected patients from Menoufia Province, Egypt. Methods: One hundred and nine blood samples, HCV monoinfected patients and co-infected with T. gondii, E. histolytica, and/or Schistosoma, were monitored and subjected to clinical chemistry and hematological examinations Results: Liver cirrhosis in patients with concomitant multiple parasites during chronic HCV infections showed a high percentage compared to HCV mono-infected patients. Moreover, significant increases in the level of alpha-fetoprotein, aspartate transaminase, prothrombin time, and the relative monocyte count were demonstrated in patients with concomitant multiple parasites during chronic HCV infections compared to HCV mono-infected patients. Changes in the levels of platelets and relative lymphocytes/neutrophils count were detected during dual or multiple infections. Conclusions: Schistosomiasis, toxoplasmosis, or amebiasis had unpropitious effects on HCV-infected patients and it is recommended to screen these parasitic diseases among HCV patients to reduce the HCV clinical outcome.
Demographic characteristics of cases with brown adipose tissue detected in 18F-fluorodeoxyglucose positron emission tomography/computed tomography imaging p. 302
Göksel Alçin, Esra Arslan
Background: Brown adipose tissue (BAT) has an essential role in regulating energy, metabolism, and thermogenesis in mammals. BAT activation is often detected in winter, especially in the female gender and in individuals with normal body mass index (BMI) by 18F-fluorodeoxyglucose positron emission tomography/computed tomography (18F-FDG PET/CT) modality. It has been reported to be associated with some factors such as age, plasma glucose, and outdoor temperature. Therefore, in this study, we aimed to investigate the characteristics of demographic, metabolic, and other variables of patients with FDG uptake in activated BAT on 18F-FDG PET/CT imaging in patients diagnosed with various types of cancer. Methods: 15752 patients diagnosed with various types of cancer who underwent whole-body 18F-FDG PET/CT imaging for routine diagnosis, staging, or follow-up between March 2017 and April 2019 were screened, and a total of 188 BAT-positive patients were included in this retrospective study. In addition to demographic patient characteristics such as age, height, and weight, data were collected such as BMI, date of birth, date and season of PET/CT imaging, laboratory findings, injection, and PET/CT imaging time, and the average outdoor temperature on the day of PET imaging and evaluated statistically. Results: A total of 188 BAT-positive patients (142 females [75.5%] and 46 males [24.5%]) were included in this study. The mean age of the patient group was 43.89 ± 13.67 years, and the mean BMI was 24.12 ± 3.56. About 103 patients (54.7%) with positive BAT were at normal weight (BMI 18.5–24.9), 49 patients (26.2%) were overweight (BMI 25–30), and 36 patients (19.1%) were obese (BMI >30). The injection time was 76.6% in the afternoon hours, whereas 77.1% of the imaging was performed in the afternoon hours. The mean fasting blood glucose (FBS) was 106.93 ± 14.28 mg/dl, and 61.7% (n = 116) of the patients were hyperglycemic. However, we found no significant relationship between BAT activation and the date of birth, place of birth, PET imaging season (relative to the northern hemisphere), and outdoor temperature. Conclusions: In our study, while BAT FDG uptake was not increased with cold exposure before PET scan and seasonally, female gender, younger age, and mean low BMI are the significant predictive value of BAT activation. Therefore, we aimed to emphasize that BAT activation should be considered to prevent the masking of the image and prevent false-positive involvement, especially in tumor tissue in risky groups.
Antioxidant, antibacterial, and cytotoxic activities of different parts of Salsola vermiculata p. 307
Saeed Mollaei, Jalaledin Ghanavi, Poopak Farnia, Parvin Abedi-Ghobadloo, Ali Akbar Velayati
Background: Salsola vermiculata is an annual plant which is broadly distributed in southwest of Asia. Due to the lack of data regarding the biological properties of different parts of S. vermiculata, the present research focused on their biological activities. Methods: Different parts of plant were harvested, and phytochemical assay of S. vermiculata parts was performed to determine the presence of phenols, flavonoids, alkaloids, fixed oils, and volatile oils. Then, their antioxidant and cytotoxicity activities of the extracts and fractions were evaluated according to DPPH and MTT assay, respectively. Furthermore, the antimicrobial activities of the extracts and fractions were determined by the disk diffusion and minimum inhibitory concentration methods. Results: According to the results, the antioxidant activity and the phenolic contents in leaves and flowers crude extracts of S. vermiculata were high, and their ethyl acetate fractions had higher activities compared to other fractions. The cytotoxic study indicated that the seeds and roots crude extracts significantly exhibited cytotoxic activities with IC50 values of 33.88, 42.92 μg/mL, respectively, and only the fixed oil fractions had cytotoxic activity. Antibacterial activity showed that the fixed oil fraction of roots had the highest activity against Staphylococcus aureus, followed by fixed oil fraction of seeds and volatile oil fraction of the roots. Conclusions: Different parts and fractions of S. vermiculata contain various bioactive compounds with different biological activities, and the results of this study could provide useful information to guide the application of S. vermiculata parts in food and pharmaceutical fields.
Antibiotic resistance, phylogenetic group, and genotyping investigation in Escherichia coli strains of gut flora in patients with colorectal cancer in Iranian population p. 313
Mahsa Mirzarazi, Mojgan Bandehpour, Ali Hashemi, Mahmoud Vahidi, Afsoon Taghavi, Soroor Bashiri, Bahram Kazemi
Background: According to the World Health Organization, the prevalence of colorectal cancer (CRC) is the third-most common cancer in Iran. The population of Escherichia coli strains of the B2 phylogenetic group as one of the components of gut microbiota is increased in the gut of people with CRC and can also play a role in the process of cancerous intestinal cells or malignancy. The most common concern about treating infections and their association with cancer is multidrug resistance (MDR). Methods: In this study, stool samples of 20 patients with CRC were examined for sensitivity to 9 antibiotics and their genotypes were determined. Results: More than 90% of the isolates were MDR. Although among 20 isolates of E. coli gut flora in CRC patients, 11 (55%), 7 (35%), 0 (0%), and 2 (10%) strains belonged to phylogenetic groups B2, D, B1, and A, respectively. Conclusions: There was no significant relationship between the B2 phylogenetic group and MDR. Furthermore, the closeness of the species based on >90% similarity, seven clusters were observed that among five clusters, similarities were observed in terms of the phylogenetic group.
In silico analysis and structural prediction of a hypothetical protein from Leishmania major p. 320
Achisha Saikia, Duhita Akhil Palherkar, Lingayya Hiremath
Introduction: Leishmania major causes mucocutaneous leishmaniasis which is characterized by chronic skin sores. In L. major, some proteins are classified as hypothetical proteins (HPs). These proteins are chains of amino acids whose existence is predicted by sequencing organisms, but their functions remain unknown. They could further be analyzed, functionally annotated, and structurally predicted to open the doors to various applications. Methods: In this study, the HP AKK31191.1 from L. major was selected from the National Center for Biotechnology Information database. Various tools were used for one-dimensional (1D), 2D structural prediction followed by predicting the 3D protein structure via ab initio and homology modeling. The structure was analyzed and validated using various in silico tools. Results: A detailed information on the physicochemical analysis of the protein was achieved. It was found that this particular HP could be located in the cytoplasm. 2D structural analysis showed that the protein consisted of random coils at a higher amount succeeded by extended strands and alpha-helix. These data were validated through a Ramachandran plot. Subsequently, the 3D structure of the protein was visualized in UCSF Chimera which portrayed the random coils, extended strands, and the alpha-helix in different colors. Conclusions: This study focused on finding the characteristic features of the HP, predicting the 3D structure, functionally annotating the protein, and finding another similarity sequence. Through structural prediction, disease-associated mutations can be identified, and other functionally significant sites can be facilitated by determining the spatial positions of active sites and other critical residues.
Platelets prohibition with clopidogrel alone versus with proton-pump inhibitors p. 327
Feryal Hashim Rada
Background: Clopidogrel and proton-pump inhibitors (PPIs) are inert drugs that need cytochrome P450 enzymes to switch chemically to their active forms. The aim of this research is to evaluate the influences of three different types of PPIs on platelet restraining effect of clopidogrel. Methods: This study consecutively enlisted 100 patients (30 females and 70 males), ranging from 45 to 60 years with coronary artery disease from Ibn Al-Nafees Hospital. The patients randomly divided into four groups and each group consists of 25 patients. One of them treated with clopidogrel tablet (75 mg daily) alone. Others treated with clopidogrel (75 mg daily) and pantoprazole (20 mg daily), or esomeprazole (20 mg daily), or rabeprazole (20 mg daily) for a period of 10 days. Light transmission aggregometry instrument was used for the estimation of maximal platelet aggregation percent (MPA%). Results: The statistical outcomes after 10 days of treatments demonstrated that high inhibition of platelet aggregation was achieved in patients on clopidogrel alone 52.5% and low inhibition of platelet aggregation was confirmed in patients on clopidogrel and rabeprazole 43.3%. Conclusions: Even each drug of PPIs that used in this study changed the MPA% as compared to clopidogrel alone, but rabeprazole had an appreciable impact on MPA% and thereby on clinical adequacy of clopidogrel as platelets aggregation preventer drug.
Predicting breast cancer using machine learning classifiers and enhancing the output by combining the predictions to generate optimal F1-score p. 331
Disha Harshadbhai Parekh, Vishal Dahiya
Background: Biomedical field has gained a lot of interest from active researchers today. Treating various diseases prevailing among the world has believed to bring huge insight in the today's research world. Second, advancement in technology has eased the work of researchers to justify their work. Machine learning (ML) is an approach being used by bioengineers today to predict diseases and to even aid them in drug discovery. Methods: Considering both the points, one of the most serious diseases, that is breast cancer here, is predicted using ML approaches. Breast cancer is classified as either benign or malignant which is to be predicted with the help of ML classifiers. A very famous dataset Wisconsin Breast Cancer Dataset is used here and is trained by three classifiers mainly support vector machine, general linear model, and neural network (NNET) against testing dataset. Testing the breast cancer prediction was carried out keeping in mind the accuracy of each of the classifiers. Results: This study is involving a generic code in R language. Conclusions: The study intends to show the usage of NNETs in breast cancer prediction using single-layered structure.
A modified method for the production of stable surface-functionalized bovine serum albumin nanoparticles p. 335
Abhishek Srivastava, Anjali Prajapati, Panchanan Pramanik, Vinay Kumar Singh
Background: To enhance the therapeutic index of drugs, various targeted drug delivery systems have been developed in recent decades. Among different drug carrier systems, albumin-based nanocarriers have acquired much attention due to its nonimmunogenic, biodegradable, biocompatible, and nontoxic nature. The present investigation deals with the development of a stable carboxyl functionalized bovine serum albumin (FBSA) nanoparticles through surface modification with chloroacetic acid. Methods: FBSA nanoparticles were synthesized by ground dispersion using ethanol as a desolvating agent; the stabilization of nanoparticles was done by glutaraldehyde. Various process modalities, namely glutaraldehyde concentration, FBSA concentration, pH, ethanol addition rate, and agitation speed, were tested to obtain stable nanoparticles of suitable size. Results: The nanoparticles of average diameter 100–120 nm with − 30 mV zeta potential and 0.1 polydispersity index were obtained in neutral and alkaline medium. Particle size and surface charge are very less influenced by varying the FBSA in 10–200 mg/ml concentration range. pH of the medium strongly influences the surface charge and particle diameter of the FBSA nanoparticles. No significant effect on particle diameter was noticed on varying the ethanol addition rate, stirring rate, and glutaraldehyde amount in the studied range. The scanning electron microscopy monochrome image and dynamic light scattering image of FBSA display that nanoparticles are of around 100 nm size. Conclusions: The present study proposes the preparation of more stable bovine serum albumin nanoparticles through surface modification. The synthesized nanoparticles will be capable to deliver the cancer drugs more effectively to the targeted tumor site.
Comparative evaluation of Salivary-Soluble Receptor for Advanced Glycation End Product (sRAGE) levels among betel chewers and chronic periodontitis patients p. 342
Rajkumar Chandini, V Vasanthi, K Raghavendhar Karthik, Krishnan Rajkumar
Background: Advanced glycation end products (AGE) are heterogeneous groups of molecules formed from the nonenzymatic reaction of reducing sugars with free amino groups of proteins, lipids, and nucleic acids. Activation of receptor for advanced glycation end products (RAGE) by ligands in a variety of cell types and tissues may play a role in oral-systemic associations. The aim of the study is to estimate the salivary-soluble RAGE (sRAGE) levels in betel chewers and compare with salivary sRAGE levels of chronic periodontitis and normal healthy controls. Methods: Detailed case history and clinical examination was done for the study participants based on the inclusion and exclusion criteria. Study participants were grouped as Group I (chewers), Group II (chronic periodontitis), and Group III (normal controls). Unstimulated saliva samples were collected and salivary sRAGE levels were calculated using the sandwich ELISA technique. Results: Individuals with pan chewing habits have demonstrated increase in salivary sRAGE compared to chronic periodontitis and normal controls. Conclusions: Understanding AGE formation and biochemistry, cellular receptors for AGE, and AGE-induced effects on extracellular and intracellular functions will serve to expedite the process of finding effective therapies that block the excessive accumulation of these species and their interaction with the signal transduction receptor RAGE.
2-Deoxy-D-glucose as an armament against COVID-19: The key to return to normality? p. 347
Mani Kruthika Mantha, Tarun Kumar Suvvari, Anna Chiara Corriero
© Biomedical and Biotechnology Research Journal (BBRJ) | Published by Wolters Kluwer - Medknow
Online since 23rd March, 2017


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Cybercriminals have infected more than 1,000,000 Android devices with adware hidden in a few applications available for download through Google Play Store. Security experts at SophosLabs have discovered 7 infected Android applications, including six QR code scanners and one smart compass.
Once installed on smartphone or tablet, the malware named Andr/HiddnAd-AJ waits for six hours, and only after that it starts displaying a lot of annoying context ads and full-screen ads, as well as sending various notices containing advertising links. Thus, cybercriminals get revenue from malvertising even if the infected application is not active.
According to the researchers, the malware could infect at least 1 million Android devices. One of the malicious applications was downloaded more than 500,000 times.
Once an infected application is launched on victim's device for the first time, it connects to malicious C&C server in order to download malware components. While the malicious activity is initially hidden, attackers also try to avoid the detection of the adware source code which built into standard Android library. In addition to standard components, attackers added "Graphics" section which contains detailed instructions for getting all the information and files required to run malicious ads.
Google has already removed the detected applications from the Google Play Store.


text:
Obituary: Ernie S. D'Agnelli, A Recreation Department Fixture Who Lived For Belmont
December 4, 2018 By Franklin B. Tucker 2 Comments
Photo: Ernie S. D'Agnelli.
If you or your children spent any time participating in an activity run by Belmont Recreation, you would have come across the big personality of "Ernie D." For nearly a half-century, Ernie D'Agnelli was a driving force at the Recreation Division, from running it's summer programs, maintaining the resemblance of order at the Field House to volunteering to cook the BBQ at the opening of the pool season.
"Ernie loved Belmont. He grew up here, went to school here, was a star on the sports fields and later became a coach for Belmont Marauder teams. More importantly, he was a mentor and role model to so many young people over the years," said June Howell, his longtime friend and work colleague.
Ernie S. D'Agnelli, who touched the lives of generations of residents with his kindness and wide smile, died on Saturday, Dec. 1, 2018. He was 64.
The cause was a heart attack, said Howell at Monday's Recreation Commission meeting.
For 41 years, D'Agnelli was a physical education teacher at the Maimonides School in Brookline. Known as Mr. D, he was an almost legendary personality at the private Jewish day school. But his heart was in the "Rec Department," said Howell, where he had worked since he was a teenager. He started as a park instructor while in high school and later developed and ran the town's first summer programs. He could be found at the Field House organizing games for adults during the week and supervising kids on Thursday nights at Open Gym. If there was a program that needed someone to run it, D'Agnelli was there to take on the task.
"He lived for Belmont," said Howell on Monday.
D'Agnelli was raised in town and graduated from Belmont High School in 1972, where he was a Hall of Fame athlete. He matriculated and played football at the University of Massachusetts, Amherst, graduating in 1976. He was an avid fan of Natick and Belmont sports, and for many years was an intricate part of several Belmont youth sports programs.
"We have missed his presence here in the office since his retirement but we will never forget his smile, his booming laugh or the impact he had on our lives," said Howell.
D'Agnelli is survived by his wife Lynne M. D'Agnelli and their children Kristin Talarico and her husband Lucas, Kerrin D'Agnelli and Lindsay D'Agnelli. He was grandfather of Jack, Co, a and Colin Talarico. He was a son of the late Ernest and Angela D'Agnelli, brother of Lisa Kazanovicz and her husband John of Reading and Andrea Vona and her husband Kevin of Belmont. Also survived by many nieces and nephews.
Visiting hours will be in the Brown & Hickey Funeral Home 36 Trapelo Rd. in Belmont on Wednesday, Dec. 5 from 4 p.m. to 8 p.m. A funeral mass will be celebrated in St Joseph Church, 128 Common St. on Thursday, Dec. 6 at 10 a.m. The burial will be private.
In lieu of flowers donations may be made in his memory to the Maimonides School c/o Development Office, 34 Philbrick Rd. Brookline MA 02445.
Filed Under: News Tagged With: Belmont, Obituary, Recreation Division
steve pannella says
I played softball with ernie for eight years with waverley insurance and we had some good times while we were playing. great player and great teammate and I was sorry to hear about his passing.
Michael Singer says
Dear mr. D's wife, I'm sorry for your loss