text:
Nutraceutical values of natural honey and its contribution to human health and wealth
Abdulwahid Ajibola1,3,
Joseph P Chamunorwa2 &
Kennedy H Erlwanger3
Nutrition & Metabolism volume 9, Article number: 61 (2012) Cite this article
The use of natural honey (NH) as a nutraceutical agent is associated with nutritional benefits and therapeutic promises. NH is widely accepted as food and medicine by all generations, traditions and civilizations, both ancient and modern. The nutritional profiles, including its use in infant and children feeding reported in different literatures as well as health indices and biomarkers observed by various researchers are illustrated in this manuscript. The review documents folk medicine, experimentation with animal models, and orthodox medical practices shown by clinical trials. This covers virtually all human organs and body systems extensively studied by different workers. The sources and adverse effects of NH contamination, as well as the preventive methods are identified. This could promote the availability of residue free honey and a wholesome natural product for domestic consumption and international market. This could also help to prevent health problems associated with NH poisoning. In addition, apicultural practices and the economic importance of honey are well documented. This report also includes information about a relatively unknown and uncommon South American stingless bee species. We concluded this review by identifying important roles for Ethno-entomologists, other Scientists and Apiculturists in the development of stingless bees to boost honey production, consumption and economic earnings.
The use of natural honey as food and medicine by mankind has been in existence from time immemorial. In fact, records have it that raw honey is the most ancient sweetener, and it was noted to have been in use throughout the world several million years ago [1]. Natural honey (NH) is a sweet, flavourful liquid food of high nutritional value [2, 3], and immense health benefits [3, 4]. NH is produced by honey-bees as blossom honey by secreting nectars of flowers, and honeydew honey (forest honey) by secreting the exudates of plant sucking insects (Aphids). NH is widely embraced by all ages, and its use transcends the barriers of culture and ethnicity. The use of honey is even advocated and embraced by all religious and cultural beliefs.
NH is a liquid spoken of by all religious books, and accepted by all generations, traditions and civilizations, both ancient and modern. The religion of Islam recommended the use of honey as food and medicine, and even named an entire chapter in the Holy Qur'an called Surah al-Nahl meaning chapter of the Honey Bee [5]. In the book of hadith, Prophet Muhammad strongly advocated the use of honey for curative and healing purposes [6]. Furthermore, the Holy Qur'an explicitly encourages the consumption of NH as a highly nutritious and health promoting food in chapter 16 thus: "And your Lord inspired the bee(s), saying: "Take your habitations in the mountains and in the trees and in what they erect. Then, eat of all fruits, and follow the ways of your Lord made easy (for you)." There comes forth from their bellies, a drink of varying colour wherein is healing for men. Verily, in this is indeed a sign for people who think" [7]. In Christendom, there are references made to the importance of bees and honey in the Bible, and these include the Books of Exodus, Judges, Mathew and Proverbs [8–11]. In accordance with this Christian holy book, the Bible, King Solomon was quoted thus: "Eat honey my son, because it is good" [11]. In fact, it was reported in the Bible that John the Baptist actually thrived on a diet including wild honey for a long period of time when he was in the desert area or while travelling in the wilderness [10]. The other sets of people, sects, traditions and civilizations that attested to the popularity of honey include Budhists, Jews, Hindus and Vedas [1, 12].
The profile of honey in the health shopping list is rising. The reason for this increased demand for NH is attributable to its popularity due to several medicinal uses that this substance has enjoyed throughout the history of mankind. It has been observed from time immemorial that NH is not only important for its medicinal attributes, but also useful as food sweetener, complete food and natural beauty agent [1]. NH has been used severally by the Tradomedical practitioners for numerous health benefits, and researchers have also documented honey's beneficial roles in modern medicine, especially in wound treatments [13, 14]. Several different surveys have been compiled on the nutritional and health aspects of honey [14–18]. However, the nutritional value and medicinal properties of NH are too numerous and highly inexhaustible to be comprehensively documented by these manuscripts. The records of honey as functional health food and uses of other honey-bee products are still incipient. Thus, the need to review some relevant materials on natural honey becomes imperative. This review documents the NH values as food and medicine, as well as enumerates the economic importance of NH production and other apicultural practices.
Honey as food
Nutritional profile
The composition of honey is mainly sugars and water (Table 1). In addition, it also contains several vitamins and minerals, including B vitamins as shown in Table 2. The other constituents of honey are amino acids, antibiotic-rich inhibine, proteins, phenol antioxidants, and micronutrients [2]. The sugars in honey are sweeter and give more energy than artificial sweeteners [2–4], and the most abundant sugar in honey is fructose (Table 1).
Table 1 Nutritional composition of honey*
Table 2 Chemical elements found in honey*
These substances are of nutritional and health importance. Some of the vitamins found in honey include ascorbic acid, pantothenic acid, niacin and riboflavin; along with minerals such as calcium, copper, iron, magnesium, manganese, phosphorus, potassium and zinc. The detailed list of vitamins, minerals, other micronutrients and trace elements found in honey is given in Tables 2 and 3.
Table 3 Other chemical elements found in honey*
The high nutritional profile of honey with wide range of nutrients (although in minute quantities), encourages its use as food. Due to the low quantities of some of the NH's essential nutrients, it is advisable for adults to take it (NH) in large quantities (70 – 95 g daily) to get the full desirable nutritional and health benefits [19–23].
Food is eaten for nourishment, metabolic activities, growth and healthy living. Regular consumption of natural honey gives all these benefits. In fact, honey is a complete meal, as shown in Tables 1 – 3. It contains major components of a meal, and micronutrients that will enhance the digestion and absorption of these major dietary components, as well as those required for metabolism and body functions. We recorded enhanced body weight gain by our rats fed blossom honey in two separate studies at different laboratories in Nigeria and South Africa [4, 24]. In 2008, Chepulis and Starkey fed honeydew honey to 8-week old rats for 52 weeks to assess weight gain. These workers show that the growth influence of honey in rodents is partly due to increased bone growth and mineralisation [25], probably due to the calcium content of honey. Our unpublished data from very recent study on NH supplemented rats confirmed this linear growth influence of honey. In his extensive review of the literature, Molan (2001) confirmed the growth stimulating property of honey [18]. He opines from his histological studies on wounds that stimulation of cell growth by honey also enhances NH healing properties.
Source of antioxidants
The presence of free radicals and reactive oxygen species (ROS) is culpable in the processes of cellular dysfunction, pathogenesis of metabolic and cardiovascular diseases (CVDs) as well as aging. The consumption of foods and substances rich in antioxidant can protect against these pathological changes and consequently prevent the pathogenesis of these and other chronic ailments. Researches indicate that NH contains several important compounds, and these include antioxidants [26, 27]. The qualitative and quantitative composition of honey (including the antioxidants constituent and the other phytochemical substances) is a reflection of the floral source as well as the variety of the particular honey. The colour of honey also influences its antioxidant content, as darker honeys are known to have higher amount than lighter honeys [28]. In their analysis of the phytochemical composition of monofloral Cuban honeys, Alvarez-Suarez and co-workers, agreed with this submission and concluded that Cuban honeys contain important phenolic, flavonoid and carotenoid concentrations with high substantial antioxidant capacity [29]. Researchers in California also submitted that human beings can be protected from the damaging effects of free radicals and ROS. The protection is through the absorption of the antioxidants from foods such as honey highly-rich in this important substance called antioxidant. The report of their study in which two buckwheat honey treatments were administered to 37 healthy human adults at the rate of 1.5 g/kg body weight, with corn syrup as control, show increased (p < 0.05) plasma total-phenolic content and plasma antioxidant. Thus, supporting the concept that phenolic antioxidants from processed honey are bioavailable, and they increase antioxidant activity of plasma. They advocated for the substitution of honey in some foods as traditional sweetener for enhanced antioxidant defence system in healthy human adults [27].
Exercise and athletic performance
The consumption of energy giving substances before, during and after any form of physical exercise improves the individual's performance and increases the rejuvenation of muscles. This is also associated with dietary supplementation with NH, which provides up to 17 g of carbohydrates for every tablespoon consumed and gives the much needed energy, thus serving as an inexpensive substitute to commercially available sporting activities enhancers. The data obtained from the Sports Nutrition and Exercise Laboratory of one University show that honey can be used effectively instead of glucose for energy replenishment during physical exercise [30]. The physiological actions of NH observed during this performance were a significant increase in heart frequency and a fairly constant blood glucose level. These suggest honey as a better substitute to glucose. Earnest and co-workers improved on this preliminary investigation in another trial by administering low (honey) or high (glucose) glycaemic index (GI) carbohydrate gels on athletes, and testing them on the performance of cyclists travelling a distance of about 65 km [31]. The results of the cycling event show that both the low (honey) and the high (glucose) GI substances caused increase in performance. However, the effect produced by eating NH surpassed that observed in the athletes fed with glucose. This aligns with other previous studies that NH consumption does not compromise metabolic and physical activities [4, 25, 26]. NH has been shown to decrease blood glucose level in hyperglycaemia such as diabetic subjects [19, 20, 32–37], plausibly due to the beneficial effects of fructose [32, 34–36], and more importantly honey's several phytochemical constituents [2, 37]. A very recent review of the hypoglycaemic effect of honey by some workers conclude that, the synergistic effect of fructose and glucose constituents of honey might contribute to the low glycaemic response after a honey meal [38]. These experimental and clinical trials show that honey is a well-tolerated liquid food.
Furthermore, honey can be an effective carbohydrate source and a better substitute to glucose for exercise and athletic performance, due to its constituent of various classes of sugars. People favour slow-burning sugars for sustenance as energy source during physical exercise. Honey is beneficial in this regard as it releases fructose slowly into the blood stream to produce a sustained energy boost and maintain homeostasis. The other major component of NH apart from fructose is glucose (Table 1). Fructose and glucose are ketose and aldose sugars respectively with chemical structural differences, and consequently different patterns of metabolism, despite both being monosaccharides with quick burning tendency. It is important to note that glucose is rapidly metabolized for absorption into the blood system for energy provision. On the other hand, fructose absorption is slow, and will continue to sustain the individual with energy, while the glucose moiety burns out. The various phytochemical constituents of honey [2] also contribute to the progressive slow rate of fructose metabolism [39]. In addition, honey contains disaccharides such as sucrose and oligosaccharides as well as other trisaccharides (Table 1) that are slow burning sugars. These could facilitate energy replenishment, muscle recuperation and enhancement of performance in athletes nourished with honey, while those relying on glucose for an energy boost might have been exhausted.
Digestion and absorption
Natural honey contains several enzymes which enhance the digestion of food substances especially carbohydrates such as sugars and starch. The additional benefit of eating honey as a source of energy over the commonly used artificial sugar is that, the major sugar constituents of NH are present as monosaccharides (simple sugars) [2]. Unlike the refined sugar (sucrose) which normally has to undergo the processes of digestion into simpler forms prior to their absorption, these sugar molecules in NH are in pre-digested forms, and can be directly absorbed into the human system. Apart from giving nutrition, the use of honey as a sweetening agent in sweets and desserts is also beneficial. As a sweetener, honey has nutritional advantages over sugar, providing some amount of small nutrients [2, 3], which act to aid digestive processes in the body. The gastrointestinal tract (GIT) contains lot of essential and beneficial bacteria, especially Bifidobacteria for the maintenance of life and good health. It has been suggested that one can increase the Bifidobacteria populations in the GIT by consuming foods with rich supply of prebiotics such as natural honey [40, 41]. Prebiotics are substances that facilitate the enhanced growth and the biological activity of these good and beneficial bacteria. The consumption of honey is important in human digestion, and this effect is produced by the honey's constituents of oligosaccharides [40–42]. Several experimental trials involving both in vitro and in vivo studies have been documented on the importance of dietary supplementation with natural honey on the growth of the beneficial bacteria (bifidobacteria and lactobacilli) and their prebiotic effects in the GIT [40–45]. One comparative study on natural (honey) and artificial (sucrose) sugars shows that honey increased both in vitro the beneficial bacteria, lactobacilli, as well as in vivo (within the small and the large intestines of experimental rats), while sucrose had no effect [46]. In some cases, the consumption of relatively large amounts of NH (between 70 to about 95 g) can produce a mild laxative effect in people with fructose malabsorption or inadequate absorption [47, 48]. Generally, honey has a laxative effect on the digestive system of individuals. Another nutraceutical function of honey is provision of calcium. Honey consumption provides calcium, which is readily absorbable and strengthen bone mass development. This can help reduce the risk of osteoporosis or low bone mass (causative agent of fractures) in old individuals. Research in animal models show that calcium absorption increased correspondingly with increased honey intake [49].
Children nutrition
There are anecdotal evidences encouraging the feeding of honey to new born babies by some customs and traditions. It is now an established fact that feeding honey to infants will improve memory and growth, reduce anxiety and enhance the children's performance in later life. In 2009, Chepulis and co workers gave scientific credence to this beneficial practice in their New Zealand behavioural study in animals [50]. They fed 8 weeks old rats with diet supplemented with either honeydew honey or sucrose, and control group with sugar-free diet (all diets patterned after typical New Zealand human diet). These workers noted improved spatial memory and reduced anxiety in the honey-fed rodents better than the other groups over the twelve months trial period. The authors concluded that early introduction of honey diet is beneficial and can improve memory loss and cognitive decline associated with aging [50].
The application of honey in human infant nutrition also revealed some interesting and beneficial observations. The palatability of honey for infants was investigated by Ramenghi and others in 2001, and these workers reported that honey was well tolerated and significantly reduced the crying phases of babies than sterile water [51]. In a review on the importance of honey relative to sucrose in children's nutrition, honey fed infants were found to have improved haematological profiles and calcium uptake, no digestion problem, lighter and thinner faeces, better skin colour, less susceptibility to diseases, and steady weight gain [52]. These beneficial effects produced by NH when included in infant formula are attributable to its effects in enhancing the gastrointestinal function which include the digestion process. The possible cause is the effect of the carbohydrate constituents, oligosaccharides in NH on intestinal flora of these children [53]. One will be doing well to children by giving honey to replace sweets and other sugary substances they are often inclined to eat.
Medicinal properties of honey
Haematology and immunity
Honey has been found to be beneficial to people suffering from anaemia. Ajibola et al. (2007) reported enhanced blood profiles in floral honey-fed adult rats [4]. The study recorded improved haemoglobin concentration (iron constituent of NH played an important role in this), increased erythrocyte count and elevated haematocrit in the honey eaters. In another laboratory, Chepulis (2007) also documented enhanced haematology and immune response in rats fed 10% honeydew honey supplemented diet [54]. The author noted higher lymphocyte count and increased neutrophil phagocytosis in NH-fed rats than control. This aligned with previous research that prebiotics can enhance immune function [55, 56] and NH is known to contain the prebiotics, oligosaccharides [4, 40, 57]. Human subjects administered with two honey treatments in a Californian study show that honey eaters have the benefit of haematoprotection in addition to blood proliferation [27]. The researchers observed that the aqueous portion of the blood (plasma) is protected by honey. This is in agreement with the fact that most of the antioxidant components in processed honey are water soluble. In summarizing the facts that honey can be considered to be a satisfactory immuno-nutrient, some workers opine that the oral administration of natural honey can stimulate and increase the production of antibody during primary and secondary immune responses against the T-cells of the thymus-dependent as well as the thymus independent antigens [58].
The use of NH can promote oral health and wellness. Molan opines that honey with high level of antibacterial activity has the potential to reduce the risk of dental caries [59]. In addition to the carioprotective effect of New Zealand manuka honey (a very potent antimicrobial honey), Molan and co-workers have shown from his extensive work on the influence of honey on oral health that honey prevents dental plaque, gingivitis, periodontics [60]. Other workers in different laboratories have also shown that honey is non-cariogenic or less cariogenic than sucrose [61–64]. The carioprotective effect of honey has been adduced to its antibacterial property, which prevents the growth of the bacteria that can cause dental caries [59, 62]. In one electron microscopy study, honey consumption was found to be safer and less inimical to oral health than drinking fruit juice [65]. There was a report of the tooth enamel being eroded just ten minutes after the consumption of fruit juice, while honey ingestion delayed this observation till half an hour after the intake of NH, and this erosion of teeth was not even as prominent or visible as that observed in the fruit juice eaters. The plausible explanation for the less cariogenic effect of honey is the protective role of NH constituents which include calcium, fluoride, phosphorous and other colloidal honey components. In summary, it can be concluded that honey has constituents with cario-protective effect.
Anecdotal evidences advocate the medicinal use of NH as therapeutic agent against the ailments of the GIT in the past [6, 66–69]. These are presently being supported by the global medicinal use of NH for the prevention, cure and the treatments of some GIT disorders such as ulcers, gastritis and gastroenteritis [70–77]. Honey has been shown to be a gastroprotective agent. Its potency in inhibiting the activity of Helicobacter pylori, that causes gastritis and peptic ulcers have been well documented [78–80]. In experimental rats, NH mitigated gastrointestinal assaults caused by alcohol, ammonia, aspirin and indomethacin [70, 71, 74, 75]. Two mechanisms have been proposed to be responsible for this protective action of honey. The first suggests that this effect is due to the antioxidant properties of honey. NH was found to maintain or enhance the level of non-protein sulfhydyl substances (such as glutathione) in gastric tissue subjected to factors inducing ulceration [70–73]. Similar observation was made when Anzer honey pre-treatment was used to prevent N-ethylmaleimide (NEM) -induced liver damage in rats [81]. The findings imply that depletion of glutathione concentration plays an aetiological role in NEM-induced liver injury, and that the hepatoprotective effect of Anzer honey may be mediated through the sulfhydryl sensitive processes. The authors concluded that honey possess antioxidant properties.
According to some authors, the second mechanism of action being proposed shows that honey intake stimulates the sensory nerves in the stomach, and this proprioceptive effect is in response to capsaicin [70, 73]. This mechanism involves the reduction of ulcer index, vascular permeability, and muscular activity of the stomach [77]. Other authors also explained this phenomenon by reporting the mitigating effect of dandelion honey intake against gastric juice acidity by more than 50% [82]. One study reported a slower passage rate of gastric content of saccharides after the intake of NH than that after ingestion of a mixture simulating honey that is glucose and fructose mixture [83], and thus, mitigating diarrhoea. The clinical uses of honey in infants and children revealed shorter duration of diarrhoea caused by bacteria. In the same vein, NH also reduced the pathogenesis and duration of viral diarrhoea unlike that associated with the use of conventional antibacterial therapy [84]. Honey was also found to be beneficial in maintaining blood-sugar levels. In honey, there is little water available to promote the growth of bacteria and yeast. In addition, honey's natural acidity inhibits some pathogens, as it has an amount of hydrogen peroxide and other substances contributing to its antibacterial effect [18].
The use of honey in the treatment of eye diseases is well documented. The ancient people used honey from Attica [85], and Indian lotus honey [86] as curative substances for eye disorders. The Indian locals still use NH as eye drops to cure eye disease till today [87–89]. The Malian people used NH as a tradomedicinal therapeutic agent against measles. The NH was usually applied on the eyes to prevent the scarring effect of the cornea which occurs as a complication of the measles infection [90]. There was an astounding success reported from NH application in clinical trials of 102 patients with different ophthalmological disorders such as (blepharitis, conjunctivitis and keratitis), hitherto not responding to conventional treatment [91]. After the NH application under the lower eyelid like an eye ointment, improvement was seen in 85% of the cases, with no deterioration seen in any of the other 15%. However, a transient stinging sensation and redness of the eye was observed soon after putting honey in the eye, but not enough to halt the treatment in all the 102 cases in the trial. The use of NH application in ophthalmology in Asia and Eastern Europe has also been reported by Molan in the review on NH use in ophthalmology [16]. In one Indian Medical College, an Ophthalmic Surgeon successfully treated bacterial caused corneal ulcers with the topical application of NH [92]. The same paper documented Meier referring to NH being used for the treatment of eyes discharging pus [92]. Molan (1999) also cited Russian authors, Mozherenkov and Prokof'eva that document a review on the use of honey in ophthalmology [16]. The Russian authors observed antibacterial, antifungal and anti-inflammatory actions with the honey application to the eye under the lower eyelid [93]. It has been used for the treatment of burns to the eye caused by chemical and thermal agents, as well as conjunctivitis, and corneal infections. This is usually done by the topical application of the undiluted NH on the affected eyes, or alternatively as a solution containing about 50% water, without any loss of potency [16].
Metabolic and cardiovascular effects
It has been shown that honey intake ameliorates risk factors of metabolic and cardiovascular diseases in patients and healthy individuals at risk. Unlike refined sugars, diabetic patients can safely and harmlessly eat this natural and sweetest sugar (fructose)-containing product, natural honey. According to Costa-Neto (1999) reported by Santos and Antonini, the Pankararé tribe of Brazil even recommended honey's use for the treatment of diabetes mellitus, bronchitis, mycosis, and throat aches amidst other ailments [94, 95]. Recently in our laboratory, we fed male and female rats with NH or sugar (golden syrup, GS) supplemented diet for 12 weeks from 7 days of age to compare their metabolic response, and see if NH is protective against metabolic syndrome (MetS). This MetS is a condition characterized by abdominal obesity, hyperglycaemia, hypertension and dyslipidaemia, and thus increased susceptibility to diabetes, kidney and heart diseases [96, 97]. In male rats, GS significantly increased (p < 0.05) blood levels of metabolic substrates (glucose and triglycerides, TGs); and caused enhanced (p < 0.001) visceral adiposity, hypercholesterolemia, hyperinsulinemia, hepatomegaly and fatty liver. These CVDs and metabolic diseases' risk factors were not observed in the NH-fed rats in this trial. We concluded that honey is cardio-protective, and its (NH) consumption could not induce MetS [unpublished results]. These results confirmed the conclusion drawn from earlier study that substituting honey for refined carbohydrates was beneficial [40]. Earlier researches from other laboratories and clinical trials further affirmed the metabolic and cardiovascular health significance of eating honey by recording some health profiles. These were reduction in the plasma levels of risk factors which include total cholesterol [19, 20]; low density lipoprotein (LDL)-cholesterol [19, 20, 98]; TGs [19, 24, 31]; glucose in normal and diabetic patients [19, 20]; C-reactive protein [19, 20]; while the health indices elevated in the blood were high density lipoprotein (HDL) cholesterol [19, 20, 25, 40]. In addition, other workers recorded higher plasma antioxidants levels in rats nurtured with natural honey relative to fructose-fed rats, and consequently low susceptibility of these subjects to CVDs [40].
Chemotherapy and wounds management
Honey has antiseptic properties, good for treating burns, infected surgical wounds and ulcers. Glenys Round, a Cancer Specialist and Julie Betts in Waikato Hospital, New Zealand reported excellent results of the therapy from patients with fungating wounds, recalcitrant leg ulcers and pressure sores using the Unique Manuka Factor (UMF)-containing honey known as manuka honey [99]. According to the Specialist, the application of honey dressings was used in these patients (including those with cancer broken through the skin), after failure of healing from conventional treatments which include radiation therapy. Another Researcher successfully treated experimental surgical wounds in Nigerian Dwarf goats with blossom honey. He observed epithelialisation and significantly higher contraction of the NH treated wounds relative to untreated wounds [13]. Other several workers had also used honey for the same purpose in human surgical wards and on experimental animals [100–105]. A comprehensive review of effect of honey on wounds is available elsewhere [16].
Antimicrobial activity
Natural honey is a very potent broad spectrum antibiotic which most multi-resistant bacteria are found sensitive to (Table 4). Alvarez-Suarez and co-workers confirm this in their report and opine that antimicrobial activity is present in all types of honey [106]. The workers suggest that hydrogen peroxide formation may play an important role as antibacterial natural products for minimizing the invasive effects of bacterial infections in the native monofloral Cuban honeys analysed. Although, the Cuban honeys varied in their chemical constituents' values, all still exhibit antimicrobial activity against both Gram-positive and Gram-negative bacteria which include Bacillus subtilis, Pseudomonas aeruginosa, Staphylococcus aureus and Escherichia coli [106]. The bacteria and other micro-organisms infections responsive to NH treatment are listed in Table 4.
Table 4 List of Bacteria and other Organisms found to be sensitive to honey*
In their various studies with about 200 New Zealand (Manuka and non-Manuka) honeys, Molan and co-workers are of the opinion that differences exist in the antibacterial and antifungal activities, although all exhibit potency [107–110]. Other pathogenic microbes reported to be susceptible to honey treatment are Candida albicans Rubella virus, Trichophyton mentagrophytes, and Leishmania parasites [109, 111–113], as shown in Table 4.
NH like any other natural foods can also be exposed to contamination by antibiotics, pesticides, heavy metals and other toxic compounds [114]. These poisonous substances can result from disease control, accidental exposure, environmental hazards and inimical human practices [115, 116]. It was reported that European health authorities found lead (Pb) in honey bought from India in early 2010 [115]. The presence of contaminants in Indian honeys was confirmed a year later in a test by the Indian Export Inspection Council. The findings showed the presence of lead and at least two antibiotics in almost 23% of the 362 test samples of honey meant for export [115]. The antibiotics could have been the residual effect of treatment and control of infection in honey-bees. A link to this hypothesis is the almost simultaneous, coincidental control of the bacterial epidemic of foulbrood disease in bee hives by Chinese beekeepers, with the use of several antibiotics manufactured in India for animal use, including chloramphenicol [115]. Medical researchers had shown that treatment of children with chloramphenicol as an antibiotic can cause susceptibility to DNA damage and carcinogenicity. The amount of chloramphenicol found in NH although minute, according public health experts, could cause a severe, fatal reaction such as aplastic anaemia in about one out of 30,000 people [115]. This led to the ban placed on honeys originating from China by the United States of America agency, Food and Drug Administration (FDA).
The high concentration of heavy metals in honey can be a source of illness to human beings. Heavy metals are chemical elements with a specific gravity that is at least five times the specific gravity of water. The heavy metals that are of concern in NH production and apicultural practices are listed in Tables 2 and 3. In small quantities, some heavy metals are nutritionally essential for a healthy life. These are referred to as the trace elements, and are listed under minerals in Table 2. The non-essential elements associated with NH are often absent or present in very minute and insignificant levels. These heavy metals of no biological and chemical significance identified in Table 3 are cobalt, molybdenum and nickel. However, there are certain heavy metals present in honey above permissible levels by pollution standards leading to toxicity [116]. The poisoning is due to these heavy metals' inability to be metabolized by the body, thus leading to their being accumulated to toxic levels within the human or animal soft tissues without being degraded or destroyed. It has been reported that Pb can cause damage of brain, kidney, nervous system and red blood cells. The other health problems caused by heavy metals toxicity include headache, metabolic abnormalities, respiratory disorders, nausea and vomiting [117].
The use of agrochemicals in growing of flowers causes contamination of nectar with heavy metals [2], such as arsenic (As), cadmium (Cd) and Pb. These three heavy metals (As, Cd, Pb) have been identified in the priority list of top 20 hazardous substances compiled by an agency of the United States of America Department of Health and Human Services, known as The Agency for Toxic Substances and Disease Registry (ATSDR) in 2001. [118]. According to ATSDR, As is the most hazardous and toxic substance, being the first on the Agency's priority list, closely followed by Pb as second, while Cd ranked seventh on the list. Arsenic poisoning could result from environmental contamination through the use of pesticides and paints manufacturing [118]. The limited sources of As pollution might be the reason for lack of As contaminated honey cases being reported, despite the severity of its hazard. Cd contaminated honey could be as a result of its (Cd) use in Pb and zinc (Zn) mining; use of pesticides; and improper handling and disposal of old, used Cd batteries. Nonetheless, Cd concentration in NH is 0 to 0.0001 mg/100 g honey (Table 3), probably due to its similar limited sources of environmental pollution like arsenic, and legislation on protection against occupational health [118]. These showed that this natural food (NH) can be said to be safe from two of the three most hazardous contaminants. However, it is known that heavy metal poisoning results from long term low level exposure to contaminants [114, 118]. Hence, no effort should be spared at ensuring the availability of wholesome NH devoid of toxic heavy metals especially Pb, which is the most commonly encountered top hazardous substance of the three identified by ATSDR as being associated with NH.
The other factors causing metal contamination of NH are the methods of honey harvesting, processing and storage. Most small scale local beekeepers use low cost metallic containers due to low purchasing power [115]. Thus, the acidic nature (pH 3.2 – 4.5) of NH (Table 1) corrodes the metal containers [115, 119]. Lead is the most documented of all heavy metals causing honey contamination [114–116], due to the various health problems it causes. The possible reason for its presence in different types of honey from several geographic locations could be as a result of the high concentration of Pb in the air due to oil extraction and automobile exhaust emissions [116]. Another environmental factor causing high Pb presence in honey could be due to poor waste disposal of paints, printing materials such as ink, as well as used dry batteries in some places [114]. The other heavy metals of public health importance found in NH apart from As, Cd and Pb are chromium (Cr) and zinc (Zn) (Table 3). The contact of honey with stainless steel surfaces during honey production can also generate a high Cr content, due to the corrosive effect of honey acidity. It has also been documented that NH storage in galvanized containers can be a source of Zn contamination [114, 120]. Therefore it is important to take into account the type and quality of equipment used to produce and store honey after harvesting as the possible sources of honey contamination with heavy metals. In addition, the increasing overwhelming demand of this natural product necessitates the promotion of all feasible activities towards ensuring quality [115]. This would increase the production of residue-free and wholesome honey for domestic and international consumption [121]. The safety of consumers and the high global demand for quality honey make international legislation on the food imperative.
The concern of Paediatricians, microbiologists, nurses, Care-givers in health centres and maternity homes as well as other health professionals for infants is in regard to the presence of toxic bacteria, Clostridium (Cl.) botulinum in natural honey. Since this bacterium may be present in natural foods, and honey mostly being a non-sterilized packaged food, the risk of contamination cannot be ruled out. In order to avoid the exposure of infants with immature GIT to the risk of contamination with Cl. botulinum and its toxin-producing spores, it is advisable not to feed infants that are below one year old with raw honey. However, in order to alleviate the concern of introducing Clostridial infection through this natural product, honey can be sterilized by gamma irradiation without any loss of NH's properties [60]; thus, preventing contamination without reducing its nutraceutical value and potency.
Honey and wealth
NH Production and consumption
Natural honey production is of high economic importance globally. The cost of honey production is minimal compared with the high returns on the investment. It has been estimated that the global market for wound care annually is between two to six billion US dollars. If part of this huge sum is used to procure the recently developed hi-tech honey dressings, it will go a long way to improve honey production. However, little attention is given to this high-yielding enterprise known as apicultural practice. According to the information on honey production and consumption available at http://www.apiservices.com/, the present annual world honey production is about 1.2 million tons, which is less than 1% of the total sugar production. The consumption of honey differs strongly from country to country. The major honey exporting countries China and Argentina have small annual consumption rates of 0.1 to 0.2 kg per capita. NH consumption is higher in developed countries, where the home production does not always meet the market demand. In the European Union, which is both a major honey producer and importer, the annual consumption per capita varies from medium (0.3 – 0.4 kg) in Denmark, France, Great Britain, Italy and Portugal to high consumers (1.0 – 1.8 kg) in Austria, Germany, Greece, Hungary and Switzerland. In countries such as Australia, Canada and United States of America, the average per capita consumption is 0.6 to 0.8 kg/year [122]. According to FAO (Food and Agriculture Organization of the United Nations) reports of 2005, China is the world largest producer of honey. Other top producers of natural honey are Argentina, Turkey and the United States of America [123]. The significant regional producers of honey include Turkey (ranked third worldwide) and Ukraine (ranked fifth worldwide) [7, 124]. Mexico is also known as an important NH producer, providing about 10% of the world's supply. There is urgent need to increase NH production by all countries worldwide to meet the high global demand of honey, which is adjudged an important substitute of refined sugars and conventional medicaments.
Apicultural practices
Apiculture is the practice of keeping honey bees (Apis indica, Apis mellifera) for its products such as NH, wax, propolis, pollens, cerume (a mixture of wax and propolis) etc. It has been shown that NH and its by-products are natural resources, yet to be taken full advantage of as economic earner of little investment with huge returns [121–125]. However, apart from honey and its by-products used for nourishment and medicine, the honey-bees and larvae also serve as source of protein for some people [94, 95, 125]. These communities harbour stingless bees, a South American species restricted to Brazil, Paraguay, and Columbia [95]. According to Bertoni reported by [95] this species are the best honey producer, but the honey is always somewhat acidic [126], good as an antibiotic. Ethno-entomologists should exploit the trait of honey prolificacy of this species, and also control the acidity of their product (for use as food). This will afford production of more honey, devoid of undesirable quality. Apicultural practices can improve economic earnings of most countries especially in the sub-Sahara African countries and other parts of the globe with forest reserves. Previous studies have shown that bees are integral inseparable part of the ecosystem. According to Costa-Neto 1998, 1999, there are no forests without bees, and there are no bees isolated from the forests [94, 126]. Bee keeping can improve small scale and cottage industries, boost foreign earnings from export especially by sub Saharan African countries with vast expanses of unused land spaces and forest reserves.
The intake of honey as food and medicine resulted in high nutritional benefit and therapeutic promise. The botanical origin plays prominent roles on the bioavailability of NH phytochemical compounds, which consequently has effects on the biological activity of honey. However, irrespective of the floral source, variety and number (mono, polyfloral or blended); honey type (blossom or honeydew honey, Manuka or non-Manuka); concentration (diluted or undiluted); bee (sting or stingless), all contain antioxidants and exhibit various degree of biochemical activities attributable to NH's potency and value as a nutraceutical agent. The sources and adverse effects of NH contamination identified should be prevented. This could promote the availability of residue-free honey and a wholesome natural product for domestic consumption and international market. This would also help to prevent health problems associated with NH toxicity, especially the most commonly encountered Pb poisoning. Apicultural practices should be encouraged and beekeeping increased especially in countries with avalanche of forests. This will increase NH production worldwide and boost the availability of honey, which is adjudged an important substitute of refined sugars and conventional medicaments. Furthermore, this will facilitate NH's use as a cheap source of energy nutrient, and as an alternative and economical medicament for most ailments. The stingless bees hitherto restricted to Brazil could be introduced to other parts of the world. The Ethno-entomologists, other Scientists and Apiculturists have roles to play in this development. This will improve apicultural practices especially among people who are sceptical of harm from sting honey bees. The cost of honey production will reduce, and domestic consumption as well as income from export will increase.
AA, Senior Lecturer, Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne campus, Ikenne 121002, Ogun State, Nigeria. KHE, Associate Professor, School of Physiology, Faculty of Health Science, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa. JPC, Senior Lecturer, Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa.
ATSDR:
Agency for Toxic Substances and Disease Registry
CVDs:
GI:
GS:
HDL:
High density lipoprotein
Low density lipoprotein
MetS:
NEM:
N-ethylmaleimide
NH:
Pb:
TGs:
UMF:
Unique Manuka Factor
Zn:
Crane E: History of honey. Honey, A Comprehensive Survey. Edited by: Crane E. 1975, William Heinemann, London, 439-488.
White JW, Doner LW: Honey composition and properties: Beekeeping in the United States. Agric Handbook. 1980, 335: 82-91.
Bogdanov S, Jurendic T, Sieber R, Gallmann P: Honey for Nutrition and Health: A Review. J Am Coll Nutr. 2008, 27 (6): 677-689.
Ajibola A, Idowu GO, Amballi AA, Oyefuga OH, Iquot IS: Improvement of some haematological parameters in albino rats with pure natural honey. J Biol Sci Res. 2007, 2: 67-69.
An-Nahl (The Bee) 16, 1 – 128: The Holy Qur'an, English translation of the meanings and Commentary. The Presidency of Islamic Researches, IFTA, Call and Guidance. 1990, Kingdom of Saudi Arabia: King Fahd Holy Qur'an Printing Complex, Al-Madinah Al-Munawarah, 730-773. 1410 A.H
Al-Bukhari M: Sahih Bukhari Nazi Publications. 1976, 740A.D, Chicago LISA, 3 Rev Edition
An-Nahl (The Bee) 16, 68 – 69: The Holy Qur'an, English translation of the meanings and Commentary. The Presidency of Islamic Researches, IFTA, Call and Guidance. 1990, Kingdom of Saudi Arabia: King Fahd Holy Qur'an Printing Complex, Al-Madinah Al-Munawarah, 753-1410 A.H
Exodus 33, 3: The Holy Bible. Authorised King James Version. 1972, Oxford University Press, New York
Judges 14, 8: The Holy Bible. Authorised King James Version. 1972, Oxford University Press, New York
Mathew 3, 4: The Holy Bible. Authorised King James Version. 1972, Oxford University Press, New York
Proverb 24, 13: The Holy Bible. Authorised King James Version. 1972, Oxford University Press, New York
Jones R: Honey and healing through the ages. Honey and healing. Edited by: Munn P, Jones R. 2001, International Bee Research Association IBRA, Cardiff
Ajibola AA: Honey in the post-surgical wound management in goats. (DVM dissertation) Nigeria. 1995, Univ of Ibadan, Nigeria, 51-
Molan P: The role of honey in the management of wounds. J Wound Care. 1999, 8: 415-418.
Molan P: Brief review of honey as a clinical dressing. Aust J Wound Manage. 1998, 6: 148-158.
Molan P: Why honey is effective as a medicine. 1. Its use in modern medicine. Bee World. 1999, 80: 79-92.
Al-Quassemi R, Robinson RK: Some special nutritional properties of honey - a brief review. Nutr Food Sci. 2003, 33: 254-260. 10.1108/00346650310507073.
Molan P: Why honey is effective as a medicine. 2. The scientific explanation of its effects. Bee World. 2001, 82: 22-40.
Al-Waili NS: Natural honey lowers plasma glucose, C-reactive protein, homocysteine, and blood lipids in healthy, diabetic, and hyperlipidemic subjects: Comparison with dextrose and sucrose. J Med Food. 2004, 7: 100-107. 10.1089/109662004322984789.
Yaghoobi N, Al-Waili N, Ghayour-Mobarhan M, Parizadeh SM, Abasalti Z, Yaghoobi Z, Yaghoobi F, Esmaeili H, Kazemi-Bajestani SM, Aghasizadeh R, Saloom KY, Ferns GA: Natural honey and cardiovascular risk factors; effects on blood glucose, cholesterol, triacylglycerol, CRP, and body weight compared with sucrose. Sci World J. 2008, 8: 463-469.
Al-Waili NS, Boni NS: Natural honey lowers plasma prostaglandin concentrations in normal individuals. J Med Food. 2003, 6: 129-133. 10.1089/109662003322233530.
Inoue K, Murayarna S, Seshimo F, Takeba K, Yoshimura Y, Nakazawa H: Identification of phenolic compound in manuka honey as specific superoxide anion radical scavenger using electron spin resonance (ESR) and liquid chromatography with colorimetric array detection. J Sci Food Agric. 2005, 85: 872-878. 10.1002/jsfa.1952.
Munstedt K, Hoffmann S, Hauenschild A, Bulte M, von-Georgi R, Hackethal A: Effect of honey on serum cholesterol and lipid values. J Med Food. 2009, 12 (3): 624-628. 10.1089/jmf.2008.0188.
Ajibola A: Chamunorwa JP, Erlwanger KH: Comparative effects of honey and sugar on the morphometry of viscera in growing Sprague-Dawley rats (Rattus norvegicus). In Book of Abstract of 31st Scientific Conference: 7–9 September 2011. 2011, Physiological Society of Nigeria (PSN), Sokoto, 9-
Chepulis L, Starkey N: The long-term effects of feeding honey compared to sucrose and a sugar-free diet on weight gain, lipid profiles, and DEXA measurements in rats. J Food Sci. 2008, 73 (1): S1-S7.
Al-Waili NS: Effects of daily consumption of honey solution on hematological indices and blood levels of minerals and enzymes in normal individuals. J Med Food. 2003, 6: 135-140. 10.1089/109662003322233549.
Schramm DD, Karim M, Schrader HR, Holt RR, Cardetti M, Keen CL: Honey with high levels of antioxidants can provide protection to healthy human subjects. J Agric Food Chem. 2003, 51: 1732-1735. 10.1021/jf025928k.
Frankel SM, Robbinson GE, Berenbaum MR: Antioxidant capacity and correlated characteristics of 14 unifloral honeys. J Apicultural Res. 1998, 37: 27-31.
Alvarez-Suarez JM, Tulipani S, Romandini S, Bertoli E, Battino M: Contribution of honey in nutrition and human health: a review. Mediterranean J Nutr Metab. 2010, 3: 15-23. 10.1007/s12349-009-0051-6.
Kreider RB, Rasmussen CJ, Lancaster SL, Kerksick C, Greenwood M: Honey: An alternative sports gel. Strength Conditioning J. 2002, 24: 50-51.
Earnest CP, Lancaster SL, Rasmussen CJ, Kerksick CM, Lucia A, Greenwood MC, Almada AL, Cowand PA, Kreider RB: Low versus high glycemic index meals carbohydrate gel ingestion during simulated 64 km cycling time trial performance. J Strength Cond Res. 2004, 18: 466-472.
Al-Waili N: Intrapulmonary administration of natural honey solution, hyperosmolar dextrose or hypoosmolar distill water to normal individuals and to patients with type-2diabetes mellitus or hypertension: Their effects on blood glucose level, plasma insulin and C-peptide, blood pressure and peaked expiratory flow rate. Eur J Med Res. 2003, 8: 295-303.
Ahmad A, Azim MK, Mesaik MA, Khan RA: Natural honey modulates physiological glycemic response compared to simulated honey and D-glucose. J Food Sci. 2008, 73: H165-H167. 10.1111/j.1750-3841.2008.00887.x.
Bahrami M, Ataie-Jafari A, Hosseini S, Foruzanfar MH, Rahmani M, Pajouhi M: Effects of natural honey consumption in diabetic patients: An 8-week randomized clinical trial. Int J Food Sci Nutr. 2009, 60: 618-626. 10.3109/09637480801990389.
Erejuwa OO, Gurtu S, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS: Hypoglycemic and antioxidant effects of honey supplementation in streptozotocin-induced diabetic rats. Int J Vitam Nutr Res. 2010, 80: 74-82. 10.1024/0300-9831/a000008.
Erejuwa OO, Sulaiman SA, Wahab MS, Sirajudeen KN, Salleh MS, Gurtu S: Glibenclamide or metformin combined with honey improves glycemic control in streptozotocin induced diabetic rats. Int J Biol Sci. 2011, 7: 244-252.
Cortés ME, Vigil P, Montenegro G: The medicinal value of honey: A review on its benefits to human health, with a special focus on its effects on glycemic regulation. Cien Inv Agr. 2011, 38: 303-317. 10.4067/S0718-16202011000200015.
Erejuwa OO, Sulaiman SA, Wahab MS: Fructose might contribute to the hypoglycemic effect of honey. Molecules. 2012, 17: 1900-1915. 10.3390/molecules17021900.
Herman RH, Zakim D: Fructose Metabolism 1. The Fructose Metabolic Pathway. Am J Clin Nutr. 1968, 21 (3): 245-249.
Busserolles J, Gueux E, Rock E, Mazur A, Rayssiquier Y: Substituting honey for refined carbohydrates protects rats from hypertriglyceridemic and prooxidative effects of fructose. J Nutr. 2002, 132 (11): 3379-3382.
Sanz ML, Polemis N, Morales V, Corzo N, Drakoularakou A, Gibson GR, Rastall RA: In vitro investigation into the potential prebiotic activity of honey oligosaccharides. J Agric Food Chem. 2005, 53: 2914-2921. 10.1021/jf0500684.
Yun YW: Fructooligosaccharides - occurrence, preparation and application. Enzyme Microb Technol. 1996, 19: 107-117. 10.1016/0141-0229(95)00188-3.
Ustunol Z, Gandhi H: Growth and viability of commercial Bifidobacterium spp. on honey sweetened skim milk. J Food Prot. 2001, 64 (11): 1775-1779.
Kajiwara S, Gandhi H, Ustunol Z: Effect of honey on the growth of and acid production by human intestinal Bifidobacterium spp An in vitro comparison with commercial oligosaccharides and inulin. J Food Prot. 2002, 65: 214-218.
Shin HS, Ustunol Z: Carbohydrate composition of honey from different floral sources and their influence on growth of selected intestinal bacteria: An in vitro comparison. Food Res Int. 2005, 38: 721-728. 10.1016/j.foodres.2005.01.007.
Shamala TR, Jyothi YS, Saibaba P: Stimulatory effect of honey on multiplication of lactic acid bacteria under in vitro and in vivo conditions. Lett Appl Microbiol. 2000, 30: 453-455. 10.1046/j.1472-765x.2000.00746.x.
Ladas SD, Haritos DN, Raptis SA: Honey may have a laxative effect on normal subjects because of incomplete fructose absorption. Am J Clin Nutr. 1995, 62: 1212-1215.
Ladas SD, Raptis SA: Honey, fructose absorption, and the laxative effect. Nutrition. 1999, 15: 591-592. 10.1016/S0899-9007(99)00092-1.
Ariefdjohan MW, Martin BR, Lachcik PJ, Weaver CM: Acute and chronic Effects of honey and its carbohydrate constituents on calcium absorption in rats. J Agric Food Chem. 2008, 56: 2649-2654. 10.1021/jf073357w.
Chepulis LM, Starkey NJ, Waas JR, Molan PC: The effects of long-term honey, sucrose or sugar-free diets on memory and anxiety in rats. Physiol Behav. 2009, 97: 359-368. 10.1016/j.physbeh.2009.03.001.
Ramenghi LA, Amerio G, Sabatino G: Honey, a palatable substance for infants: from De Rerum Natura to evidence-based medicine. Eur J Pediatr. 2001, 160: 677-678.
Bianchi EM: Honey: Its importance in children's nutrition. Amer Bee J. 1977, 117: 733-
Rivero-Urgell M, Santamaria-Orleans A: Oligosaccharides: application in infant food (review). Early Hum Dev. 2001, 65: 43-52.
Chepulis LM: The effects of honey compared with sucrose and a sugar-free diet on neutrophil phagocytosis and lymphocyte numbers after long-term feeding in rats. J. Compl Integrat Med. 2007, 4 (1): 1-7.
Schley PD, Field CJ: The immune-enhancing effects of dietary fibres and prebiotics. Br J Nutr. 2002, 87: S221-S230. 10.1079/BJN/2002541.
Yamada K, Tokunaga Y, Ikeda A: Dietary effect of guar gum and its partially hydrolyzed product on the lipid metabolism and immune function of Sprague Dawley rats. Biosci Biotechnol Biochem. 1999, 63: 2163-2167. 10.1271/bbb.63.2163.
Doner LW: The sugars of honey – a review. J Sci Food Agric. 1977, 28: 443-456. 10.1002/jsfa.2740280508.
Al-Waili NS, Haq A: Effect of Honey on Antibody Production Against Thymus-Dependent and Thymus-Independent Antigens in Primary and Secondary Immune Responses. J Med Food. 2004, 7 (4): 491-494. 10.1089/jmf.2004.7.491.
Molan PC: The potential of honey to promote oral wellness. Gen Den. 2001, 49: 584-589.
English HK, Pack AR, Molan PC: The effects of manuka honey on plaque and gingivitis: a pilot study. J Int Acad Periodontol. 2004, 6: 63-67.
Decaix C: Comparative study of sucrose and honey. Chir Dent Fr. 1976, 46: 59-60.
Steinberg D, Kaine G, Gedalia I: Antibacterial effect of propolis and honey on oral bacteria. Am J Dent. 1996, 9: 236-239.
Sela MO, Shapira L, Grizim I, Lewinstein I, Steinberg D, Gedalia I, Grobler SR: Effects of honey consumption on enamel microhardness in normal versus xerostomic patients. J Oral Rehabil. 1998, 25: 630-634. 10.1046/j.1365-2842.1998.00274.x.
Edgar WM, Jenkins GN: Solubility-reducing agents in honey and partly-refined crystalline sugar. Br Dent J. 1974, 136: 7-14. 10.1038/sj.bdj.4803124.
Grobler SR, du Toit IJ, Basson NJ: The effect of honey on human tooth enamel in vitro observed by electron microscopy and microhardness measurements. Arch Oral Biol. 1994, 39: 147-153. 10.1016/0003-9969(94)90110-4.
Khotkina ML: Honey as part of therapy for patients with stomach ulcers. Collect papers Irkutsk State Med Inst. 1955, : 252-262.
Menshikov FK, Feidman SI: Curing stomach ulcers with honey. Sovetskaya Meditsing. 1949, 10: 13-14.
Slobodianiuk AA, Slobodianiuk MS: Complex treatment of gastritis patients with high stomach secretion in combination with (and without) a 15–20 % solution of honey. 1969, Citation from [16]
Salem SN: Honey regimen in gastrointestinal disorders. Bull Islamic Med. 1981, 1: 358-362.
Ali ATMM: Natural honey accelerates healing of indomethacin induced antral ulcers in rats. Saudi Med J. 1995, 16: 161-166.
Ali ATMM: Natural honey exerts its protective effects against ethanol-induced gastric lesions in rats by preventing depletion of glandular non protein sulfhydryls. Trop Gastroenterol. 1995, 16: 18-26.
Ali ATMM: Natural honey prevents ischaemia-reperfusion induced gastric mucosal lesions and increased vascular permeability in rats. Eur J Gastroenterol Hepatol. 1997, 9: 1101-1107. 10.1097/00042737-199711000-00014.
Al Swayeh OA, Ali ATMM: Effect of ablation of capsaicin sensitive neurons on gastric protection by honey and sucralfate. Hepato-Gastroenterol. 1998, 45: 297-302.
Gharzouli K, Amira S, Gharzouli A, Khennouf S: Gastro protective effects of honey and glucose-fructose-sucrose-maltose mixture against ethanol-, indomethacin-, and acidified aspirin induced lesions in the rat. Exp Toxicol Pathol. 2002, 54: 217-221. 10.1078/0940-2993-00255.
Gharzouli K, Gharzouli A, Amira S, Khennouf S: Prevention of ethanol-induced gastric lesions in rats by natural honey and glucose-fructose-sucrose-maltose mixture. Pharmacol Res. 2001, 43: 509-10.1006/phrs.2000.0792.
Kandil A, El-Banby M, Abdel-Wahed K, Abdel-Gawwad M, Fayez M: Curative properties of true floral and false non floral honeys and induced gastric ulcers. J Drug Res Egypt. 1987, 17: 103-106.
Nasuti C, Gabbianelli R, Falcioni G, Cantalamessa F: Antioxidative and gastro protective activities of anti-inflammatory formulations derived from chestnut honey in rats. Nutr Res. 2006, 26: 130-137. 10.1016/j.nutres.2006.02.007.
Ali ATMM, Chowdhury MNH, Al-Humayyd MS: Inhibitory effect of natural honey on Helicobacter pylori. Trop Gastroenterol. 1991, 12: 139-143.
Al Somal N, Coley KE, Molan PC, Hancock BM: Susceptibility of Helicobacter pylori to the antibacterial activity of Manuka honey. J R Soc Med. 1994, 87: 9-12.
Osato MS, Reddy SG, Graham DY: Osmotic effect of honey on growth and viability of Helicobacter pylori. Dig Dis Sci. 1999, 44: 462-464. 10.1023/A:1026676517213.
Korkmaz A, Kolankaya D: Anzer honey prevents N-ethyl maleimide-induced liver damage in rats. Exptal Toxicol Pathol. 2009, 61: 333-337. 10.1016/j.etp.2008.07.005.
Baltuskevicius A, Laiskonis A, Vysniauskiene D, Ceksteryte V, Racys J: Use of different kinds of honey for hepatitis A treatment and for reduction of increased acidity of gastric juice. Zemdirbyste Mokslo Darbai. 2001, 76: 173-180.
Pokorn D, Vukmirovic V: Velocity of gastric emptying of saccharides after administering honey and pure invert sugar. Book of Proceedings of III International Apitherapy Symposium. Edited by: Bukarest Apimondia. 1978, Portoroz, Yugoslavia, 277-279.
Haffejee IE, Moosa A: Honey in the treatment of infantile gastroenteritis. Br Med J. 1985, 290: 1866-1867. 10.1136/bmj.290.6485.1866.
Beck B, Smedley D: Honey and your health. 1944, McBride, New York, USA, 2
Fotidar M, Fotidar SN: Lotus' honey. Indian Bee J. 1945, 7: 102-
Mahawar MM, Jaroli DP: Animals and their products utilized as medicines by the inhabitants surrounding the Ranthambhore National Park, India. J Ethnobiol Ethnomed. 2006, 2: 46-10.1186/1746-4269-2-46.
Solovan A, Paulmurugan R, Wilsanand V, Ranjith Sing AJA: Traditional therapeutic uses of animals among tribal population of Tamil Nadu. Indian J Trad Knowl. 2004, 3: 2206-2207.
Ranjit Singh AJA, Padmalatha C: Ethno-entomological practices in Tirunelveli district, Tamil Nadu. Indian J Trad Knowl. 2004, 3: 4442-4446.
Imperato PJ, Traore : Traditional beliefs about measles and its treatment among the Bambara of Mali. Trop Geograph Med. 1969, 21: 62-67.
Emarah MH: A clinical study of the topical use of bee honey in the treatment of some occular diseases. Bull Islam Med. 1982, 2 (5): 422-425.
Meier KE, Freitag G: Ober die andbiodschen Eigenschaften von Sacchariden und Bienenhonig. Z Hyg Infekt. 1955, 141: 326-332. 10.1007/BF02149973. Citation from [16]
Mozherenkov VP: Prokof'eva: Honey treatment of poscherpetic opacities of the cornea. Oftarmologicheski Zhurna. 1984, 3: 188-Oftarmologicheski Zhurna. (in Russian). Citation from [16]
Costa Neto EM: A etnocategoria "inseto" e a hipótese da ambivalência entomoprojetiva. Acta Biológica Leopoldensia. 1999, 2: 7-14.
Santos GM, Antonini Y: The traditional knowledge on stingless bees (Apidae: Meliponina) used by the Enawene-Nawe tribe in western Brazil. J Ethnobiol Ethnomed. 2008, 4: 19-10.1186/1746-4269-4-19.
Ford ES, Giles WH: A comparison of the prevalence of the metabolic syndrome using two proposed definitions. Diabetes Care. 2003, 26: 575-581. 10.2337/diacare.26.3.575.
Johnson RJ, Segal MS, Sautin Y, Nakagawa T, Feig DI, Kang D, Gersch MS, Benner S, Sa'nchez-Lozada LG: Potential role of sugar (fructose) in the epidemic of hypertension, obesity and the metabolic syndrome, diabetes, kidney disease, and cardiovascular disease. Am J Clin Nutr. 2007, 86 (4): 899-906.
Gheldof N, Engeseth NJ: Antioxidant capacity of honeys from various floral sources based on the determination of oxygen radical absorbance capacity and inhibition of in vitro lipoprotein oxidation in human serum samples. J Agric Food Chem. 2002, 50: 3050-3055. 10.1021/jf0114637.
Yahya H: Allah's Miracles in the Qur'an. Translation by C Rossini. Edited by: Livingstone D, Talib QM, Willoughby J. 2005, Goodword Books, New Delhi
Al-Waili N, Saloom K: Honey to treat post-operative wound infections due to gram positive and gram negative bacteria following caesarian section and hysterectomies. Eur J Med Res. 1999, 4: 126-141.
Oryan A, Zaker R: Effects of topical application of honey on cutaneous wound healing in rabbits. Zentralb Veterinarmed A. 1998, 45: 181-188.
Bergman A, Yanai J, Weiss J, Bell D, David P: Acceleration of wound healing by topical application of honey. An animal model. Am J Surg. 1983, 145: 374-376. 10.1016/0002-9610(83)90204-0.
Wadi II, Al-Amin H, Farouq A, Kashe FH, Khaled SA: Sudanese bee honey in the treatment of suppurating wounds. Arab Medico. 1987, 3: 16-18.
Efem SEE: Clinical observations on the wound healing properties of honey. Brit J Surg. 1988, 75: 679-681. 10.1002/bjs.1800750718.
Hejase MJ, Bihrle R, Coogan CL: Genital Foumier's gangrene: experience with 38 patients. Urology. 1996, 47 (5): 734-739. 10.1016/S0090-4295(96)80017-3.
Alvarez-Suarez JM, Tulipani S, Diaz D, Estevez Y, Romandini S, Giampieri F, Damiani E, Astolfi P, Bompadre S, Battino M: Antioxidant and antimicrobial capacity of several monofloral Cuban honeys and their correlation with color, polyphenol content and other chemical compounds. Food Chem Toxicol. 2010, 48: 2490-2499. 10.1016/j.fct.2010.06.021.
Molan PC: The antibacterial activity of honey. 2—Variation in the potency of the antibacterial activity. Bee World. 1992, 73: 59-75.
Cooper RA, Molan PC, Harding KG: The sensitivity to honey of Gram-positive cocci of clinical significance isolated from wounds. J Applied Microbiol. 2002, 93: 857-863. 10.1046/j.1365-2672.2002.01761.x.
Brady N, Molan P, Bang L: A survey of non-manuka New Zealand honeys for antibacterial and antifungal activities. J Apicul Res. 2004, 43: 47-52.
Lin SM, Molan PC, Cursons RT: The in vitro susceptibility of Campylobacter spp. to the antibacterial effect of manuka honey. Eur J Clin Microbiol Infect Dis. 2008, 93: 339-344.
Zeina B, Othman O, Al-Assad S: Effect of honey versus thyme on Rubella virus survival in vitro. J Altern Complement Med. 1996, 2: 345-348. 10.1089/acm.1996.2.345.
Zeina B, Zohra BI, al Assad S: The effects of honey on Leishmania parasites: an in vitro study. Trop Doct. 1997, 27 (Suppl 1): 36-38.
Kilicoglu B, Kismet K, Koru O, Tanyuksel M, Oruc MT, Sorkun K, Akkus MA: The scolicidal effects of honey. Adv Ther. 2006, 23: 1077-1083. 10.1007/BF02850228.
Bogdanov S: Contaminants of bee products. Apidologie. 2006, 38: 1-18.
Schneider A: Asian honey, banned in Europe, is flooding U.S. grocery shelves. 2011, The Food Watchdog, Seattle Washington, Assessed from http://www.food safetynews.com /2011/08/honey-laundering/ on 14/04/12, 7 Assessed from on 14/04/12
Bibi S, Husain SZ, Malik RN: Pollen analysis and heavy metals detection in honey samples from seven selected countries. Pak J Bot. 2008, 40 (2): 507-516.
Garcia-Fernadez AJ, Garcia-Sanchez JA, Gomez-Zapata M, Luna A: Distribution of Cadmium in blood and tissues of wild birds. Arch Environ Contam Toxicol. 1996, 30 (2): 252-258. 10.1007/BF00215805.
Anonymous: Heavy metal toxicity. 2012, Life Extension Foundation, Fort Lauderdale Florida, Assessed from http://www.lef.org/protocols/prtcl-156.shtml on 16/04/2012 Assessed from on 16/04/2012
Anklam E: A Review of the Analytical Methods to Determine the Geographical and Botanical Origin of Honey. J Food Chem. 1998, 63 (4): 549-562. 10.1016/S0308-8146(98)00057-0.
González-Paramas AM, Gómez-Barex JA, García-Villanova RJ, Rivas-Pala T, Ardanuy-Albajar R, Sánchez_ Sánchez J: Geographical discrimination of honeys by using mineral composition and common chemical quality parameters. J Sci Food Agric. 2000, 80: 157-165. 10.1002/(SICI)1097-0010(20000101)80:1<157::AID-JSFA506>3.0.CO;2-B.
McKee B: Prevention of residues in honey: A future perspective. Apiacta. 2003, 38: 173-177.
Apicultural services: World Honey Production. The Honey Book by Bogdanov S. 2011, Bee Product Science, Muehlethurnen, 48-53. Assessed from http://www.bee-hexagon.net on 16/04/12 Assessed from on 16/04/12
FAO: Some global market considerations beekeeping: Importance for Cuba. 2007, Food and Agriculture Organization (FAO) Statistics Division, Rome, Assessed from http://www.centrorisorse.org/some-global-market-considerations-beekeeping-importance-for-cuba.htmlon 23/12/11 Assessed from on 23/12/11
Ukrinform: Ukrainian honey – World Congress Triumpher. 2009, at Montpellier, France
Rodrigues AS: Até quando o etnoconhecimento sobre as abelhassem ferrão (Hymenoptera, Apidae, Meliponinae) será transmitido entre gerações pelos índios guarani m'byá da aldeia morro da saudade, localizada na cidade de São Paulo, estado de São Paulo, Brasil?. Sitientibus Série Ciências Biológicas. 2006, 6: 343-350.
Costa-Neto EM: Folk Taxonomy and cultural significance of "Abeia"(Insecta: Hymenoptera) to the Pankararé, Northeastern Bahia State, Brazil. J Ethnobiol. 1998, 18: 1-13.
The Doctoral study that led to this review was supported by grants from the Education Trust Fund (ETF), Abuja Nigeria; and the University of the Witwatersrand, Johannesburg, South Africa.
Department of Physiology, Faculty of Basic Medical Sciences, Olabisi Onabanjo University, Ikenne campus 121002, Ogun State, Nigeria
Abdulwahid Ajibola
Department of Veterinary Anatomy and Physiology, Faculty of Veterinary Science, University of Pretoria, Onderstepoort, South Africa
Joseph P Chamunorwa
School of Physiology, Faculty of Health Sciences, University of the Witwatersrand, 7 York Road, Parktown 2193, South Africa
Abdulwahid Ajibola & Kennedy H Erlwanger
Kennedy H Erlwanger
Correspondence to Abdulwahid Ajibola.
KHE mooted the idea of the review; AA carried out the literature search; and AA, KHE and JPC wrote the paper. All authors read and approved the final manuscript.
Ajibola, A., Chamunorwa, J.P. & Erlwanger, K.H. Nutraceutical values of natural honey and its contribution to human health and wealth. Nutr Metab (Lond) 9, 61 (2012). https://doi.org/10.1186/1743-7075-9-61
Economic importance
Ethno-entomologist
Health indices
Stingless bee


text:
San Lorenzo Valley Girls Softball
Learning to play ball and have fun!
Learning Basic Skills
Mountain Dream
Sponsorship & Fundraisers
SLVGS Highlighted Moment
All Highlighted Moments
About SLVGS
We appreciate all sponsorship towards Mountain Dream, you can contribute yourself by using the following link: https://www.paypal.me/slvgsdream
Fall Fees
12U Krepelka (Sponsored) $190.00 USD12U Edgemon $235.00 USD10U Colby (Sponsored) $90.00 USD
Summer Summary:
2019's 12uC Mountain Dream team, together for their 5th year, continued a strong run of success. They played 7 tournaments, compiling an overall record of 17-12-1.
They came home overall tournament Champions from Manzanita Mayhem in Prunedale in early June, and from Strawberry Jam in Watsonville in late July, capping off the summer. In between, they practiced and played hard throughout. They attended a week-long Nike sleep away softball camp in Rocklin for the second straight year. They traveled to Incline Village and had a beautiful time playing up there. But the highlight of the Summer had to be the Cal State Games. Needing to make the top 8 teams out of 21 at a qualifier in Sunnyvale, these Dreamers finished 4th, which allowed them to travel to San Diego to participate in State Championships.
The Friday night opening festivities were amazing. They took place at Qualcomm Stadium. The girls and coaches got to parade into the Stadium through the tunnel, and then around the field. They met and traded pins with many, many other girls and teams. Navy paratroopers dropped into the stadium, there was an amazing national anthem and a live motocross exhibition. And in the games the girls acquitted themselves beautifully, going 2-2.
On to Fall!
Mark Your Calendars January 10, 2022
Come join the fun November 8, 2021
Best Snack Shack Crew! March 4, 2020
10U Scrimmage February 23, 2020
The families of SLVGS February 16, 2020

redpajama_set_name: RedPajamaCommonCrawl


"The toughest part of the war was lack of sleep"
Coupled with the lack of shelter or water and a very poor diet, Australian and New Zealand soldiers on Gallipoli found the lack of sleep almost impossible to get used to. The cramped conditions, noise, heat and flies made a good night's rest a rare luxury. Men often fell asleep where they were sitting – or standing, as New Zealand veteran Jerry Duffel recalls in this radio interview recorded in the 1960s.
Malnourished, diseased, traumatised and exhausted, soldiers on Gallipoli found it nearly impossible to get a good night's sleep. Modern medical studies have shown that prolonged sleep deprivation can be fatal by leading to poor physical performance, lack of focus and co-ordination, and impaired judgement.
Tragically, one New Zealand soldier learnt this at first hand. Private Jack Dunn of the Wellington Infantry Battalion, who had just returned from hospital after suffering from dysentery, fell asleep on sentry duty at Quinn's Post in July 1915. He was court-martialled and sentenced to death for endangering his unit by falling asleep.
General Sir Ian Hamilton, the British officer who headed the Allied Mediterranean Expeditionary Force, overturned the death sentence in early August, but Private Dunn was killed in the Battle of Chunuk Bair a few days later. His story features in Te Papa's exhibition Gallipoli: The scale of our war.


text:
Former President Carter Highlights Success in Guinea Worm Eradication
Kane Farabaugh
Former President Jimmy Carter and former first lady Rosalynn Carter tour the "Countdown to Zero" with Donald Hopkins, former director of Carter Center Health Programs, during a press event at the Jimmy Carter Library and Museum in Atlanta, Georgia, Jan. 11, 2017. (K. Farabaugh/VOA)
ATLANTA, GEORGIA —
When former President Jimmy Carter announced he was battling cancer in an August 2015 news conference at his Atlanta-based nonprofit Carter Center, he shared that one of his hopes was that the last Guinea worm would be eradicated before he died.
"I still have the same hope," Carter told VOA in an exclusive interview at the Carter Center, almost 17 months after his cancer announcement.
He is still focused on promoting the fight against Guinea worm, also known as dracunculiasis, a neglected tropical parasitic disease that as recently as the 1980s afflicted millions of people in 21 countries.
It is transmitted by drinking water that is contaminated with microscopic larvae that carry the parasite. The worm matures in the human body over the course of a year. Once mature, the worm, sometimes as long as one meter, slowly emerges through blisters on the skin, generating intense pain for those infected.
FILE - Ajak Kuol Nyamchiek watches while John Lotiki, a nurse with the Carter Center, bandages blisters on her leg from where a Guinea worm is emerging, Abuyong, Sudan, Nov. 4, 2010.
"They afflict people in the poorest and most isolated places in the world," Carter told an audience gathered at the Jimmy Carter Library and Museum on Wednesday, during an unveiling of its newest exhibit "Countdown to Zero," a look at disease elimination and eradication programs produced in conjunction with the American Museum of Natural History.
The Carter Center also has released its annual update on global Guinea worm eradication numbers.
In 2016, three countries reported cases of Guinea worm — South Sudan, Ethiopia and Chad. A fourth country, Mali, which had cases of the disease in 2015, is reported to be free of the parasite for the first time.
"It means you've had a 25 percent reduction in the number of countries reporting cases," said Frank Richards, who heads several of the Carter Center's eradication and elimination programs.
While the eradication effort now focuses on those three countries where the parasite remains, the overall number of cases has slightly increased.
"The difference between 22 cases last year and 25 cases this year is trivial," said Donald Hopkins, former director of the Carter Center's health programs and an expert on disease eradication.
But the challenge that remains is reaching and maintaining a presence in those villages where the parasite is still infecting unsuspecting hosts.
"When you get to the final numbers of cases, generally they are in the places that are the most difficult to reach," Richards explained, "either because of remoteness or insecurity and instability, and Mali is one of those examples, as is South Sudan."
"Those last few cases in any eradication program are always the most severely problematic," Carter told VOA.
Former President Jimmy Carter talks to the media during a press event at the Jimmy Carter Library and Museum in Atlanta, Georgia, Jan. 11, 2017. (K. Farabaugh /VOA)
Carter's health
As the Carter Center's global fight against Guinea worm wages on, so does his battle with cancer.
"I'm doing fine, I'm much better than I was when we had the press conference here," he told CNN's Sanjay Gupta during a panel discussion on eradication efforts in the Carter Center's auditorium. "I had cancer in my liver, part of it that was removed, and I had four spots on my brain that were malignant. I get another MRI tomorrow, but so far my brain and liver have been clear of the disease."
While his battle with cancer appears successful, Carter, 92, is mindful that even if his hope of outliving the last Guinea worm isn't realized, he is confident the Carter Center and its partners will reach the goal of complete eradication.
"I'm not looking forward to not being here," he told VOA, through his signature grin, "but I think when I'm gone, the effort will not be abandoned, it will be continued, maybe with an even greater degree of enthusiasm because it would be in my memory and that sort of thing. So I don't feel concerned about the future."
Of the effort, Richards told VOA, "I think it's in our human DNA to reach a supreme accomplishment, and this is the supreme accomplishment in public health."
Kane Farabaugh is the Midwest Correspondent for Voice of America, where since 2008 he has established Voice of America's presence in the heartland of America.
Mali Eradicates Guinea Worm
Wars and Dogs Complicate WHO's Bid to Kill Off Guinea Worm
Jimmy Carter Hopeful for Guinea Worm Eradication in Africa
Small Asteroid to Pass Near Earth Thursday
Asteroid on Path for Close Call With Earth
US Seeks Reengagement with China to Stop Illicit Fentanyl as Blinken Heads to Beijing
Ancient Jerusalem Hand Imprint Baffles Israel Experts


The Preschool Ministry at McLaurin Heights Baptist Church provides a loving and nurturing nursery environment allowing parents to relax and enjoy Bible Study and Worship. Your child is special to us and we strive to make your child's first impression of church a positive one.
For your preschool-aged children, we create a fun and interactive environment where your child will engage in crafts, play time, and hear about a great God who loves them.


17 Jun Tested in osx: arm-none-eabi-objdump -D 70000entrepreneurs.com 70000entrepreneurs.com: file format elf32 -littlearm. Disassembly of 70000entrepreneurs.com: 22 Mar Answer The GNU ARM toolchain included with Simplicity Studio includes a bina. arm-none-eabi-objdump -D -bbinary -marm. Hello,. I am trying to build bare metal project for SAM4s. When i try to disassemble with arm-none-eabi-objdump it does not contain functions i.
This is available via the objdump utility if you have compiled your objects with debug enabled (-g flag); e.g. using CodeSourcery's arm-none-eabi chain, you can. 24 Oct My understanding was that arm-none-eabi-gcc will not use the _start in "crt0.o" but it will use arm-none-eabi-objdump -D output.o > 70000entrepreneurs.com 23 Jan When I run objdump help and look at the supported architectures, I don't arm- none-eabi-objdump -b binary -marm -D 70000entrepreneurs.com -Mforce-thumb. Back to Package. usr/; usr/arm-none-eabi/; usr/arm-none-eabi/bin/; usr/arm-none- eabi/bin/ar usr/bin/arm-none-eabi-objcopy; usr/bin/arm-none-eabi-objdump.


text:
Hindi & Urdu
Taking Stock: The PTI Government's Economic Performance in its First Year
September 8, 2019 by Shahroo Malik
When it came to power in August 2018, the Pakistan Tehreek-e-Insaf (PTI) government promised to build a Naya Pakistan (new Pakistan) by improving the state of the economy, providing jobs and affordable housing, and fighting corruption. However, at the end of one year in office, the PTI government is far from fulfilling the major promises that it campaigned on and which catapulted it into power. In fact, the country's gross domestic product (GDP) is down, fiscal deficit is at a three-decade-high, tax revenues have declined, key industries like manufacturing and agriculture have slowed, and inflation is in double digits.
Economic crises are not new to Pakistan. In fact, the PTI government inherited a high current account deficit from the previous Pakistan Muslim League-Nawaz (PML-N) government. Couple that with a balance of payments crisis and the Imran Khan government was forced to knock on the doors of the International Monetary Fund (IMF) in its first few months for a USD $6 billion loan. However, this loan came with strict demands to enact austerity measures and higher taxes, a tighter monetary policy, a depreciated rupee, and more, adding to the PTI's woes and restricting its ability to achieve the economic goals it had set for its first year. If this past year is any indication, the PTI government has a long way to go to fix Pakistan's economic problems.
At the end of the PTI government's first year in office, Pakistan's economic growth is stunted, business investment by the private sector has slowed down, and the standard of living has worsened, due to high inflation and low employment rates.
The severe austerity measures that Pakistan had to undertake as part of the IMF bailout program have slowed down its economic growth. While the government was estimating a 6.2 percent GDP growth in FY2019, Pakistan's GDP came down to 3.29 percent, as compared to 5.8 percent in the past year. The World Bank now estimates that Pakistan's GDP will further fall to 2.7 percent in 2020.
Lower growth comes on the back of a slowdown in the manufacturing sector, which fell 3.6 percent in the year, due to a higher cost of borrowing and production. The tight monetary and fiscal policies introduced by the PTI have led to the contraction of large-scale manufacturing industries for the first time in 10 years. The government cut energy subsidies, making petroleum and diesel more expensive. In addition, the country's central bank, the State Bank of Pakistan (SBP), increased the key monetary rate from 8.5 percent in October 2018 to 13.25 percent in July 2019. While the interest rates have been increased in line with the IMF's requirements and to rein in inflation, higher interest rates also discourage private investments and dry up liquidity in the system, leading to lower consumption and hence, lower GDP growth.
Foreign direct investment inflows have slumped in the past year—a massive 59 percent drop—to USD $73.4 million, indicating a fall in the investor sentiment for the Pakistani market and its currency.
Fiscal deficit numbers released in July also paint a grim picture. Fiscal deficit, which is the difference between the government's income and expenditure, was at a three-decade high of 8.9 percent when expressed as a percentage of GDP, going up from 6.6 percent last year.
One of the only silver linings for Pakistan was that remittances—the money wired back home from its diaspora population overseas—increased by nearly 10 percent.
Obstacles and Missed Opportunities
It is important to note that most of the unpopular fiscal policies implemented by the PTI government in the last one year – rise in prices, increasing taxes on imports, tighter interest rates, and devaluing the rupee – were requirements of the much-needed IMF loan. Thus, many of Pakistan's economic problems are structural and cannot be overcome in one year. However, the PTI government also failed to bring about the right policies to soften the blow of measures mandated by the IMF.
For instance, the IMF required Pakistan to curtail its expenses and increase its revenues, thereby reducing its fiscal deficit, which the PTI government agreed to do through heavy taxation. The government tried to broaden the tax base through various measures, such as amnesty schemes, and it claimed that taxpayers did increase by 137,000 during FY2018-19. The government also did away with zero-rated tax on key export industries like textile and leather products, bringing back a 17 percent sales tax on these products. In addition, the government made efforts to close the loopholes in the system by changing the taxation mechanism. However, as research shows, tax amnesty schemes are not particularly effective in increasing revenues and the PTI's scheme only raised USD $70 billion in revenue, below expectation and even lower than a similar scheme floated by the PML-N in 2018. And overall revenues from tax remained flat. Instead, the PTI's indirect taxes hit the poor and middle class in Pakistan, with inflation rising from 5.84 percent to 10 percent in a year, essential commodities becoming more expensive, and the job market shrinking. The new taxation mechanism introduced by the PTI government was complex and cumbersome, criticized by both traders and the business community, who were already struggling to attract customers due to high inflation. Furthermore, the reduction in imports also reduced the custom collections.
Another example of the PTI government not doing enough to counteract the country's economic situation was failing to cash in on the biggest benefit of a weak rupee—an increase in exports. The Pakistani rupee weakened by 32 percent against the dollar, going from Rs 121 for a dollar in 2018 to Rs 160 to a dollar in 2019. A weak rupee means goods become cheaper for overseas buyers and exporters get more rupees for their dollar earnings. But Pakistan's exports declined by 1.9 percent in the fiscal year gone by. Some of this, undeniably, is due to the rise in prices of imports, which made imported machinery and raw material expensive for Pakistani businesses. However, some of it is also because of structural problems such as Pakistan's narrow exports basket, made up of mostly low value-added items and often not of a quality that can compete effectively in the international market, as well as the country's heavy reliance on a few markets such as the United States, the United Kingdom, and the Middle East.
Pakistan's Economic Future under PTI
The first year of the Khan-led PTI government has been a bumpy ride. The PTI, which made tall claims of reviving the economy and never knocking on the doors of the IMF, is struggling to meet any of its economic targets, largely due to the economic restrictions placed by the IMF. The PTI's government's inability to tackle these grave issues has led to growing resentment among the masses, affecting the party's popularity.
The government would do better by easing some of its regressive taxation policies and reducing indirect taxes—which directly affect the common man—and by taxing the wealthy businessmen and landlords instead. It is also imperative that the PTI government look out for new export markets that will bring in more foreign reserves and reduce its dependency on loans and foreign aid.
With the first quarterly review of the IMF around the corner, these measures take on even more urgency for Pakistan.
Editor's Note: August 2019 marked the first anniversary of the Pakistan Tehreek-e-Insaf's ascent to power and Imran Khan's first year in office as Pakistan's prime minister. In this series, SAV contributors Fahad Nabeel, Fizza Batool, and Shahroo Malik assess Khan's performance and that of his cabinet over the past year, analyzing the impact on Pakistan's governance, economic development, and foreign relations. Read the entire series here.
Image 1: shahzebyounas-Flickr via Stimson Center
Image 2: Asif Hassan via Getty Images
Posted in Politics & Economics, Economics, Economy, Imran Khan One Year, Pakistan
Shahroo Malik
Shahroo Malik is currently working as a Research Associate at Institute of Strategic Studies Islamabad (ISSI). She's a GDI Development Leadership Scholar and holds degrees in MSc International Development from University of Manchester, UK (2016) and BS (Hons) Economics from NUST, Islamabad (2014). Her research interests include Indo-Pak relations and South Asia's economic and development issues.
جنوبی ایشیا کے تزویراتی ماحول میں نظریاتی اختلاف
Sajid Shapoo
بھارت اور پاکستان کے مابین بالاکوٹ تنازعے نے جنوبی ایشیاء کے تزویراتی توازن میں ایک اور ہنگامہ خیز باب کا اضافہ کیا ہے۔ فروری ۲۰۱۹ […]
November 7, 2019 - Sajid Shapoo Views 0
Climate Change in India and South Asia: Intensifying Local Grievances
Mohammed Sinan Siyech
One of the most critical global challenges in the coming years is the existential threat humans face from climate change. While climate change is a […]
October 30, 2019 - Mohammed Sinan Siyech Views 0
SAV Review: How Much Does Nuclear Superiority Matter in South Asia?
Beenish Pervaiz
The Start of a New Race for Nuclear Superiority? Over the past 72 years, India and Pakistan have fought three full-scale wars and had multiple […]
November 4, 2019 - Beenish Pervaiz Views 0
Stay informed Sign up to our newsletter below
One thought on "Taking Stock: The PTI Government's Economic Performance in its First Year"
Shiraz Sheikh says:
There is one correction to be made, it should be Rs.70 billion instead of USD 70billion
design by Cast from Clay.


text:
'Off the charts' defense helps…
'Off the charts' defense helps Ravens overcome QB Lamar Jackson's 4 interceptions in 16-10 win over Browns
When the Ravens needed a stop late Sunday night, when their offense just couldn't push them across the finish line against the Cleveland Browns, they showed Ray Lewis on the videoboard inside M&T Bank Stadium.
This is the Lamar Jackson era in Baltimore, and it probably will be for a while now, but sometimes the original recipe works just as well as the newfangled stuff. This soon after Thanksgiving, why mess with tradition? On a night of career worsts for Jackson, it was the Ravens' defense that locked down a crucial divisional win, tapping into the franchise's old glory in another wild prime-time matchup.
Needing to keep the Browns out of the end zone over the game's final 70 seconds, the Ravens didn't even let Cleveland get past its first-down marker. Tyus Bowser, playing to the standard Lewis set at linebacker over his 17 years in purple, broke up a third-down pass and stopped tight end David Njoku 3 yards short of the sticks one play later to seal a 16-10 win.
"Defense was just off the charts," coach John Harbaugh said after his 23rd win over the Browns (6-6) as the Ravens' coach, tied with the New England Patriots (against the New York Jets) for the most against one team in that span. "I mean, that's one of the best defensive performances that we've seen out here in a long time. To hold that offense down the way they did, to hold that rushing attack down the way they did … I thought our guys played tremendously well across the board on defense."
It was a win the Ravens (8-3) were happy to take into their trip next Sunday into Pittsburgh, where the reeling Steelers (5-5-1) await. The Ravens held Cleveland to 262 yards of total offense, the Browns' second fewest this season, and forced two turnovers. Kicker Justin Tucker hit all three of his field-goal attempts, including 49- and 52-yarders. There were no major injuries to report postgame.
With their third win in four games, the Ravens kept their lead in the AFC North over the Bengals, who'd opened Sunday's slate of games by throttling Pittsburgh in Cincinnati, 41-10. And with the Tennessee Titans falling to New England, the Ravens retook their spot atop the AFC. Breathing down their neck are the Patriots (8-4), Titans (8-4), Kansas City Chiefs (7-4), Bengals (7-4) and Buffalo Bills (7-4).
Sunday's performance was not one Jackson would be eager to revisit. In his first game back since a mystery illness that sidelined him in Week 11, he finished 20-for-32 for 165 yards, one touchdown and a career-worst four interceptions. He became the first quarterback to throw four picks in a win since 2013, and he set a career high for interceptions in a season (12).
According to Stats Perform, the Ravens are the only team in the Super Bowl era to score fewer than 17 points, finish with fewer than 325 total yards, throw at least four more interceptions than their opponent and still win. Teams in those scenarios were 0-275-1 in the regular season and postseason before Sunday.
Time and again, an oft-criticized defense got the Ravens out of trouble. Their goal for Sunday, cornerback Marlon Humphrey said, was to hold the Browns' top-ranked rushing attack to 80 yards. Cleveland got only halfway there. Even with defensive end Calais Campbell sidelined for the first time this year by a concussion, Browns running backs Kareem Hunt and Nick Chubb finished with a combined 36 yards on 15 carries. Mayfield added 4 yards. The Browns' longest carry all game went for a mere 9 yards.
"The key was definitely to stop the run and kind of have our chances with Baker and his weapons," Humphrey said. Mayfield, playing through injuries in maybe his final game in Baltimore with the Browns, finished 18-for-37 for 247 yards and a touchdown. "We felt everything goes through their run game. Once they get their run game going, the play-action comes. So we felt if we could make them one-dimensional, our best chance of winning would be that way."
On offense, the Ravens got just enough from Jackson to lead for three-plus quarters. After a dreadful, three-interceptions-in-five-drop-backs kind of first half, he came out after halftime without his black sleeves and with some old magic. In the first half, he'd finished 10-for-17 for 74 yards and watched the Ravens get two field goals. In their first possession of the second half, he went 4-for-4 for 63 yards and delivered a highlight-reel touchdown.
His final two completions on the drive were vintage Jackson. On third-and-4 near midfield, Jackson scrambled to the sideline before throwing a high-arcing pass to tight end Mark Andrews, who was sprinting downfield on an improvised route against safety Ronnie Harrison Jr. Andrews not only drew the pass-interference penalty as he came back to the ball but also caught it with one hand.
"I knew it was a catch," said Andrews, who led the Ravens with four receptions for 65 yards. "So I was like, 'They better give me that dang catch, man.'"
Three plays after the 39-yard completion, Jackson bought just enough time to launch one into the end zone. First, he side-stepped a diving Jadeveon Clowney. Then he dropped back, and farther back, and farther back, until he was 15 yards beyond where he'd taken the shotgun snap. He swung around just before defensive end Myles Garrett could line him up for a sack, spotted Andrews uncovered and threw to the goal line.
Andrews' diving 13-yard grab gave the Ravens a 13-3 lead and Jackson a chance to breathe. With the touchdown secured, he pointed both hands at Garrett, who stared at him in apparent disbelief, before coming over to embrace the Browns' star. There was a lot to take in.
"He didn't really say nothing," Jackson said. "He just shook his head. … He was just giving me props on the play, that's all."
Cleveland's offense finally took its cue. Helped by a roughing-the-passer penalty on Bowser (one sack and three quarterback hits), the Browns covered 87 yards in five plays. Mayfield found tight end David Njoku for a sliding 20-yard catch that was upheld after a long review. With just over a quarter remaining, the Ravens' lead was down to 13-10.
Toward the end of another offensively challenged fourth quarter — just two Browns first downs, another Jackson interception — Tucker gave the Ravens some breathing room with just over a minute left, nailing a 49-yarder, his 55th straight make in the fourth quarter or overtime. The Browns had no answer.
"Our defense, we want to take pride in whether they can score at the end," Humphrey said. "When we [are on defense], all we've got to do is stop the team four times, [and] we want to take pride in being able to deliver. I remember C.J. [Mosley] got that pick back there against the Browns [in Week 17 of 2018]. And it's so special when you end the game on defense. Taking a knee is the best play in the game, but getting a fourth-down stop is right there next to it."
The first half Sunday was not the offensive explosion that was the teams' last prime-time meeting, a 47-42 instant-classic Ravens win in Cleveland last December that had 35 points in the fourth quarter alone. It was instead a showcase for quarterbacking ineptitude.
Jackson tied his career high of three interceptions in less than three minutes of game time. On the first, wide receiver Rashod Bateman tipped a pass to outside linebacker Malcolm Smith, who deflected it to cornerback Denzel Ward. On the second, safety Grant Delpit stepped in front of a telegraphed pass over the middle to Andrews. On the third, safety Harrison capitalized on Jackson's apparent miscommunication with Andrews, who ran one way as Jackson passed the other, to Harrison.
"I feel like those drives, when the interceptions came, we could've done something on those drives," said Jackson, who couldn't identify a common denominator in the interceptions. "We could've put points on the board. I just told my team, 'That's me. I owe y'all.'"
The Browns' first-half turnovers were fewer but more creative. Late in the second quarter, with Cleveland on the edge of field-goal range, wide receiver Jarvis Landry (six catches for a game-high 111 yards) took a shotgun snap and waited for someone to get open. He soon scrambled into trouble. Ravens outside linebacker Odafe Oweh tracked him down for a strip-sack, and inside linebacker Patrick Queen pounced on the fumble for the turnover.
Two drives later, after Cleveland capitalized on Jackson's first pick for a short-field field-goal drive, it was Mayfield who ended up as the punchline. On another drop-back in field-goal range, Mayfield backpedaled and backpedaled, buying time from Oweh and safety Chuck Clark. When he finally wound up to throw, he did so without the ball. Oweh fell on the fumble at the Ravens' 49; their defense was credited with a team sack.
"Just happened on the pump fake," Mayfield said. "I lost the grip on the ball. It's just one of those things. I absolutely hate it. The sequence of events was crazy. We get the turnover and get good position, then we turn it over."
Injuries did Cleveland no favors. The Browns lost All-Pro right tackle Jack Conklin, making his first start since a Week 8 elbow injury, to a first-quarter knee injury after Oweh ran him over on a bull rush. Harrison was sidelined briefly. So was Clowney. Tight end Harrison Bryant left with a first-half ankle injury.
As the Browns limped back to Cleveland with questions about Mayfield's viability in the short and long term, the Ravens vowed to make the most of their sixth win this season by six or fewer points. They've won despite defensive implosions. They've won with Jackson struggling. "Nobody gets flustered," Harbaugh said afterward. There might be better teams outside Baltimore, but there's no better place than first.
"We're in control of our own destiny, which is a beautiful thing, but we've got to get better," Andrews said. "We've got to get better in every aspect, but we've got a bunch of fighters on this team. Like I said, we believe, we trust each other, and we're going to come each and every day to work, to get better, just trying to be the best team we can be. I think if we do that throughout these weeks, especially these divisional games, we're going to reap the benefits of that."
RAVENS@STEELERS
Sunday, 4:25 p.m.
TV: Chs. 13, 9 Radio: 97.9 FM, 1090 AM
Line: Ravens by 3


Silver starfish recycled from vintage silver plates.
1 1/2 " drop from a handcrafted sterling silver ear wire.
Each pair is a one of a kind and therefore the pattern may vary slightly. Please visit the 'About' page at http://www.mixedmetalmimi.com to learn more about how these earrings were created.