text:
HOMEProfessor
Professor and Dean Kiyoshi Kita
PhD (Pharmacy), Pharmacist
Personal/work Web page addresses
http://www.tmgh.nagasaki-u.ac.jp/about_tmgh/dean
I was educated at Department of Biological Sciences, The University of Tokyo, and gradated in 1980. I joined Department of Biological Sciences, The University of Tokyo as assistant professor (1980 – 1983), and moved to Department of Parasitology, Juntendo University, School of Medicine (1983). Later, I was promoted to lecturer (1987-1990). Then, promoted to associate professor of Department of Parasitology, The Institute of Medical Science, The University of Tokyo (1991-1998). In 1998, I was appointed as Professor Department of Biomedical Chemistry, Graduate School of Medicine, The University of Tokyo and retired in 2016. In 2015, I was appointed as Dean of TMGH by cross-appointment system between The University of Tokyo and Nagasaki University.
Giving lectures (Biochemistry of metabolism, Drug development and Molecular Parasitology) in Nagasaki University and other Universities.
Biochemistry of metabolism of pathogens and drug development.
The country/countries where you work currently
Japan, Central and South America, Southeast Asia, Africa, USA and Europe.
In silico, in vitro, X-ray crystallography, and integrated strategies for discovering spermidine synthase inhibitors for Chagas disease. Yoshino, R., Yasuo, N., Hagiwara, Y., Ishida, T., Inaoka, D.K., Amano, Y., Tateishi, Y., Ohno, K., Namatame, I., Niimi, T., Orita, M., Kita, K., Akiyama, Y. & Sekijima, M. (2017) Sci. Rep. 7, 6666
Expression, purification, and crystallization of type 1 isocitrate dehydrogenase from Trypanosoma brucei brucei. Wang, X., Inaoka, D.K., Shiba T., Balogun, E.O., Allmann, S., Watanabe, Y., Boshart, M., Kita, K. & Harada, S. (2017) Protein Expr. Purif. 138, 56-62
Glycerol kinase of African trypanosomes possesses an intrinsic phosphatase activity. Balogun, E.O., Inaoka, D.K., Shiba, T., Tokuoka, S.M., Tokumasu, F., Sakamoto, K., Kido, Y., Michels, P.A.M., Watanabe, Y., Harada, S. & Kita K.
(2017) Biochim. Biophys. Acta (General Subjects) 1861, 2830-2842
Biochemical studies of membrane bound Plasmodium falciparum mitochondrial L-malate:quinone oxidoreductase, a potential drug target. Hartuti, E.D., Inaoka, D.K., Komatsuya, K., Miyazaki, Y., Miller, R.J., Xinying, W., Sadikin, M., Prabandari, E.E., Waluyo, D., Kuroda, M., Amalia, E., Matsuo, Y., Nugroho, N.B., Saimoto, H., Pramisandi, A., Watanabe, Y., Mori, M., Shiomi, K., Balogun, E.O., Shiba, T., Harada, S., Nozaki, T. & Kita K. (2018) Biochim. Biophys. Acta (Biogentics) 1859, 191-200.
Ubiquinone binding site of yeast NADH dehydrogenase revealed by structures binding novel competitive- and mixed-type inhibitors. Yamashita, T., Inaoka, D.K., Shiba, T., Oohashi, T., Iwata, S., Yagi, T., Kosaka, H., Miyoshi, H., Harada, S., Kita, K. & Hirano, K. (2018) Sci. Rep. 8, 2427
Contribution from basic research in Japan to the health and wellfare of the people in the world.
Professor Kiyoshi Aoyagi
http://www.med.nagasaki-u.ac.jp/public-h/staff/index.html
Department of Public Health, Nagasaki University Graduate School of Biomedical Sciences
1979 – 1985 – Nagasaki University School of Medicine (undergraduate)
1989 – 1989 – Nagasaki University Graduate School of Medicine
1989 Nagasaki University Hospital (Orthopedics)
1989 Tagawa City Hospital (Orthopedics)
1991 Kitakyushu General Hospital (Orthopedics)
1993 Mitsugi General Hospital (Orthopedics)
1995 Hawaii Osteoporosis Center (Research fellow)
1997 Public Health, Nagasaki University School of Medicine
2002 Professor, Public Health, Nagasaki University Graduate School of Biomedical Sciences 2007 Professor, Graduate School of International Health Development Nagasaki University
1998 – present – Medical care & Public Health
2001 – present – Thesis Research on Public Health
2001 – present – Seminar on Public Health
2001 – present – Practice on Public Health
2002 – 2003 – First-year Seminar
2004 – 2009 – Health Science
2007 – 2014 – Environmental Health
2012 – 2014 – Nutrition and Health
Epidemiology of bone health and lifestyle-related disease
Statistical analysis of rheumatoid arthritis
Tamai M, Kita J, Nakashima Y, Suzuki T, Horai Y, Okada A, Koga T, Kawashiri SY, Iwamoto N, Ichinose K, Arima K, Yamasaki S, Nakamura H, Origuchi T, Uetani M, Fukushima A, Aoyagi K, Eguchi K, Kawakami A. Combination of MRI-detected bone marrow oedema with 2010 rheumatoid arthritis classification criteria improves the diagnostic probability of early rheumatoid arthritis. Ann Rheum Dis 73:2219-2220,(2014)
Kitahara H, Ye Z, Aoyagi K, Ross PD, Abe Y, Honda S, Kanagae M, Mizukami S, Kusano Y, Tomita M, Shindo H, Osaki M. Associations of vertebral deformities and osteoarthritis with back pain among Japanese women: the Hizen-Oshima study. Osteoporos Int. 24(3):907-915,(2013)
Osaki M, Tatsuki K, Hashikawa T, Norimatsu T, Chiba K, Motokawa S, Furuichi I, Doiguchi Y, Aoyagi K, Shindo H. Beneficial effect of risedronate for preventing recurrent hip fracture in the elderly Japanese women. Osteoporosis Int 23(2): 695-703,(2012)
Tamai M, Kawakami A, Iwamoto N, Kawashiri SY, Fujikawa K, Aramaki T, Kita J, Okada A, Koga T, Arima K, Kamachi M, Yamasaki S, Nakamura H, Ida H, Origuchi T, Aoyagi K, Uetani M, Eguchi K.Comparative study of the detection of joint injury in early-stage rheumatoid arthritis by MRI of wrist and finger joints and physical examination, Arthritis Care Res, 63(3):436-439(2011)
Abe Y, Takamura N, Ye Z, Tomita M, Osaki M, Kusano Y, Nakamura T, Aoyagi K, Honda S.Quantitative ultrasound and radiographic absorptiometry are associated with vertebral deformity in Japanese Women:the Hizen-Oshima study.Osteoporos Int, 22(4):1167-1173(2010)
Tropical medicine generally concerns developing countries and the problems of community health and disease. In the class, we also cover the basic concepts of public health, policies and measures. In the process of "health transition", many developing countries have an aging population with a growing number of patients exhibiting heart/cerebrovascular disease and malignant tumors, while traditional infectious diseases are yet to be overcome. In Japan, on the other hand, deaths from infectious diseases have declined, while non-infectious diseases such as heart/cerebrovascular diseases and malignant tumors account for 60% of deaths. We study Japan's past public health policies and current and future public health measures so as to draw lessons for application to developing countries.
Professor of Clinical Medicine Koya Ariyoshi
M.D.(Japan), DTM&H (London), MSc Clinical Tropical Medicine (London), PhD (U.K.)
http://www.tm.nagasaki-u.ac.jp/internal/nekkennaika.htm
kari@nagasaki-u.ac.jp
Department of Clinical Medicine, Institute of Tropical Medicine (NEKKEN)
Department of Infectious Diseases, Nagasaki University Hospital
School of Tropical Medicine and Global Health, Nagasaki University
Honorary Professor, Clinical Research Department, Faculty of Infectious Tropical Medicine, London School of Tropical Medicine and Hygiene, UK
I had my residency training in internal medicine in Tokyo, 1986-1988. From those days I was interested in working in Africa, which let me do DTMH in London, followed by a post-graduate clinical training in Harare Central Hospital, Zimbabwe, 1989 where I encountered my life work, AIDS. My master project on HIV viral load at LSHTM in 1990 was very successful that I was offered a job as a clinical research fellow at the Jefferiss Wing, St. Mary's Hospital. My asset of multi-disciplinary human-network has been established when working in London, Oxford and West Africa for 8 years as well as in Tokyo at NIID for 3 years and in Thailand for JICA for 4 years.
I am the course director of Master of Tropical Medicine (MTM) where I teach clinical tropical medicine, malaria and non-malaria febrile illness, STD and HIV/AIDS. I also facilitate the tropical infectious disease case discussion.
As a chief of NEKKEN training/education center, I also organize the three-month diploma course of tropical medicine.
HIV research had been a core of my carrier before joining NEKKEN. It broadened my skills to understand a disease from multidisciplinary aspects such as behavioral, epidemiological, clinical science, molecular immunology and virology. Most of my work has derived from clinical-epidemiology settings such as cohort or case-control studies. I enjoy digging out clinical research questions by seeing patients and discussing with medical professionals. On joining to the current group of NEKKEN, my research topic has been broaden toward pneumonia in low, middle and high-income countries, non-malarial febrile illness such as typhus, leptospirosis. Now we have on-going studies in infectious disease wards in North Vietnam, the Philippines and Japan.
Discussing in an overcrowded ward in Bac Mai Hospital, Vietnam with Dr. Thuy, one of the most experienced I.D. physicians.
Hyperlink to the NAOSITE of each paper will be posted if it is "open access", so that viewers can jump straight to the text of the paper.
Kitashoji E, Koizumi N, Lacuesta TLV, Usuda D, Ribo MR, Tria ES, Go WS, Kojiro M, Parry CM, Dimaano EM, Villarama JB, Ohnishi M, Suzuki M, Ariyoshi K. Diagnostic Accuracy of Recombinant immunoglobulin-like Protein A-Based IgM ELISA for the Early Diagnosis of Leptospirosis in the Philippines. PLoS Negl Trop Dis 9(6): e0003879.(2015)
Morimoto K, Suzuki M, Ishifuji T, Yaegashi M, Asoh N, Hamashige N, Abe M, Aoshima M, Ariyoshi K; Adult Pneumonia Study Group-Japan (APSG-J). The burden and etiology of community-onset pneumonia in the aging Japanese population: a multicenter prospective study. PLoS One. 10(3): e0122247.(2015)
Hamaguchi S, Cuong NC, Tra DT, Doan YH, Shimizu K, Tuan NQ, Yoshida LM, Mai LQ, Duc-Anh D, Ando S, Arikawa J, Parry CM, Ariyoshi K, Thuy PT. Clinical and Epidemiological Characteristics of Scrub Typhus and Murine Typhus Among Hospitalized Patients with Acute Undifferentiated Fever in Northern Vietnam. Am J Trop Med Hyg. pii: 14-0806.(2015)
Dhoubhadel BG, Yasunami M, Nguyen HA, Suzuki M, Vu TH, Thi Thuy Nguyen A, Dang DA, Yoshida LM, Ariyoshi K. Bacterial load of pneumococcal serotypes correlates with their prevalence and multiple serotypes is associated with acute respiratory infections among children less than 5 years of age. PLoS One. 31;9(10):e110777.(2014)
M Mori, N Wichukchinda, R Miyahara, A Rojanawiwat, P Pathipvanich, T Maekawa, T Miura, P Goulder, M Yasunami, K Ariyoshi, P. Sawanpanyalert. HLA-B*35:05 is a protective allele with a unique structure amongst HIV-1 CRF01_AE-infected Thais, where the B*57 frequency is low. AIDS ; 28(7): 959-67.(2014)
Link to other publications
http://www.ncbi.nlm.nih.gov/sites/myncbi/1n5JSXaavr65l/bibliography/48630402/public/?sort=date&direction=ascending
My asset is a human-network developed while working as a AIDS-researcher and a clinician in the UK MRC Laboratories, The Gambia, West Africa for 6 years. I then spent 4 years in Thailand for a JICA-project on HIV/AIDS; since becoming a professor of Nagasaki University, developed various clinical-epidemiology research projects in Vietnam, the Philippines and Japan; also have a role in the infectious disease ward at the University Hospital. Head of center for training/education, NEKKEN; Deputy Dean of the School of Tropical Medicine and Global Health. Message for students: " if you want to make a substantial impact on health in resource-constrained setting, you should work hard."
Professor Koichi Izumikawa
M.D., PhD.
http://www.med.nagasaki-u.ac.jp/mmi/did/
http://www.mh.nagasaki-u.ac.jp/nice/
Research gate or Linked-in account links
http://www.researchgate.net/researcher/38153266_Koichi_Izumikawa
Department of Infectious Diseases, Unit of Molecular Microbiology and Immunology, Graduate School of Biomedical Sciences (GSBS)
http://www.tecd.prj.nagasaki-u.ac.jp/en/program/member.html
The American Society for Microbiology
The Japanese Society of Internal Medicine
The Japanese Respiratory Society
The Japanese Association for Infectious Diseases
The Japanese Society of Chemotherapy
The Japanese Society of Medical Mycology
1994 – Nagasaki Univ. School of Medicine, awarded MD
2000 – Postgraduate School, Laboratory Medicine, Nagasaki University School of Medicine, awarded Ph.D.
2003 – Clinical Mycology Section, LCI/NIAID, National Institutes of Health
2005 – Assistant professor, Second Department of Internal Medicine, Nagasaki University School of Medicine
2009 – Molecular Microbiology Section, LCID/NIAID, National Institutes of Health
2009 – Assistant professor, Department of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
2011 – Senior Assistant professor, Department of Respiratory Medicine, Nagasaki University Graduate School of Biomedical Sciences
2013 – Present – Director, Nagasaki University Hospital Infection Control and Education Center
2014 – Present – Professor, Department of Infectious Diseases, Unit of Molecular Microbiology and Immunology, Nagasaki University Graduate School of Biomedical Sciences
Subject at TMGH: Medical Microbiology III
Message to the students: Emerging and re-emerging diseases such as the Ebola virus disease in West African countries and the Dengue fever in Japan are becoming real threats and we do not know what comes next. I am involved in the management of patients with various infectious diseases as well as infection control at the Nagasaki University Hospital. Extensively high skills, knowledge and preparation are required for deadly infectious disease control. I can offer chances to learn the practical management of these infectious diseases in this course and hope to see many students.
Teaching at GSBS and Infectious Control and Education Center: Clinical Infectious Diseases Studies, Infectious Diseases Control and Infectious Diseases Studies
Pathogenesis and drug resistance of fungi
Development of new diagnosing tools and treatment
Verweij PE, Ananda-Rajah M, Andes D, Arendrup MC, Brüggemann RJ, Chowdhary A, Cornely OA, Denning DW, Groll AH, Izumikawa K, Kullberg BJ, Lagrou K, Maertens J, Meis JF, Newton P, Page I, Seyedmousavi S, Sheppard DC, Viscoli C, Warris A, Donnelly JP.
International expert opinion on the management of infection caused by azole-resistant Aspergillus fumigatus.
Drug Resist Updat. 2015 Jul-Aug;21-22:30-40. doi: 10.1016/j.drup.2015.08.001. Epub 2015 Aug 7.
Tashiro M, Izumikawa K, Ashizawa N, Narukawa M, Yamamoto Y. Clinical significance of methicillin-resistant coagulase-negative staphylococci obtained from sterile specimens. Diagnostic Microbiology and Infectious Disease, 81(1), pp.71-75; 2015.
http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/35001/1/DMID81_71.pdf
Izumikawa K, Watanabe A, Miyashita N, Ishida T, Hosono H, Kushimoto S, Kohno S. Efficacy and safety of garenoxacin tablets on clinically diagnosed atypical pneumonia: Postmarketing surveillance in Japan. Journal of Infection and Chemotherapy, 20(9), pp.541-548; 2014.
http://naosite.lb.nagasaki-u.ac.jp/dspace/bitstream/10069/34811/1/JIC20_541.pdf
Takahashi T, Maeda K, Suzuki T, Ishido A, Shigeoka T, Tominaga T, Kamei T, Honda M, Ninomiya D, Sakai T, Senba T, Kaneyuki S, Sakaguchi S, Satoh A, Hosokawa T, Kawabe Y, Kurihara S, Izumikawa K, Kohno S, Azuma T, Suemori K, Yasukawa M, Mizutani T, Omatsu T, Katayama Y, Miyahara M, Ijuin M, Doi K, Okuda M, Umeki K, Saito T, Fukushima K, Nakajima K, Yoshikawa T, Tani H, Fukushi S, Fukuma A, Ogata M, Shimojima M, Nakajima N, Nagata N, Katano H, Fukumoto H, Sato Y, Hasegawa H, Yamagishi T, Oishi K, Kurane I, Morikawa S, Saijo M. The First Identification and Retrospective Study of Severe Fever With Thrombocytopenia Syndrome in Japan. J Infect Dis. 209(6), pp.816-827,2014
Izumikawa K, Izumikawa KI, Takazono T, Kosai K, Morinaga Y, Nakamura S, Kurihara S, Imamura Y, Miyazaki T, Tsukamoto M, Yanagihara K, Hara K, Kohno S. Clinical features, risk factors and treatment of fulminant Mycoplasma pneumoniae pneumonia: A review of the Japanese literature. Journal of Infection and Chemotherapy, 20(3), pp.181-185; 2014
Emerging and re-emerging diseases are becoming real threats in the world and we do not know what comes next as well as when it happens. I am involved in the management of patients with various infectious diseases as well as infection control in Nagasaki University Hospital. Extensively high skills, knowledge and preparation are required for deadly infectious disease. I can offer chances to learn the practical management of these infectious diseases in this course and hope to see many students.
Professor Junko Okumura
Pharmacist, MPH (U of Michigan), PhD
http://www.researchgate.net/profile/Junko_Okumura
Nagasaki University, Institute of Tropical Medicine (Main work station).
Please refer the TMGH Syllabus.
Will be filled later
You might also consider using a PubMed Bibliography Collection as it can be used to easily keep your publications up to date and provide a list of publication references, for example, for your CV or as a web link – please see below.
Please refer 6. Research gate.
Fearing that I would regret that I did not accomplish anything, on an impulse I went to work overseas in the field where I realized how much I had to learn. I then entered graduate school at 37 years old and became a late-blooming researcher, despite the fact that I used to hate studying when I was young. To regret doing something or to regret not doing something, the choice is yours. You should find out solutions for development and health by yourself. Textbooks and classes are just tools which provide you with clues.
Professor Hiroki Ozawa
http://www.med.nagasaki-u.ac.jp/psychtry/
Division of Neuropsychiatry
Unit of Translational Medicine
1985/03 School of Medicine, Sapporo Medical University
1990/03 Ph.D. Graduate School of Medicine, Sapporo Medical University
1993/04-1999/12 Lecturer , Dept. Neuropsychiatry, Sapporo Medical University
2000/01-2001/11 Assistant Professor, Dept. Neuropsychiatry, Sapporo Medical University
2001/12-2004/09 Associate Professor, Dept. Neuropsychiatry, Sapporo Medical University
2003/10 – pres. Professor, Division of Neuropsychiatry, Unit of Translational Medicine, Graduate School of Biomedical Sciences, Nagasaki University
Psychiatry, Global mental health
mhGAP Intervention Guide for mental, neurological and substance use disorders in non-specialized health settings
Our department executes a long-term investigation of epidemiology such as the prognosis of patients who suffer from schizophrenia, their mental and physical health conditions, which are caused by Atomic bomb or the eruption of Unzen Fugendake.
The molecule, inherited historical research and investigation on schizophrenia, and the cause of a causal mental disease such as Bi-polarity depression are the main streams of research in our department now.
In the latter researches we investigate the correlation of structural abnormality and the psychological illness of the brain, and examine how the mental disease medicine affects the neural stem cells. We try to connect the three of them.
For instance, about 10 percent of the victims from the disaster of the Fugendake eruption are still suffering from mental symptoms, on the other hand many of them have recovered from the disaster. In addition, the more that the treatment period is prolonged, the worse the prognosis of schizophrenia, therefore it is important that diagnosis and treatment are conducted as early as possible.
Using genetics and biological research, I would like to verify the factors in this epidemiologic study.
In this laboratory, we are conducting researches on long-term outcomes for schizophrenic patients and the mental/physical health of victims of the atomic bombs and the disaster on Mt. Fugen.
Current main themes are the molecular/genetic study of schizophrenia and pathobiologic study to discover the causes of endogenous mental disorders including bipolar disorder.
In recent studies, I have been examining the effects of antipsychotic drugs on neural stem cells, studying the correlation between mental disorder and structural abnormality in the brain. In the future, I plan to establish a more academic research system by integrating these three studies.
For example, approx. 10% of the victims of the Mt. Fugen disaster still suffer from psychoneurosis, even though most of them have already recovered. Additionally, the prognosis of schizophrenia worsens as the treatment period lengthens, demonstrating the importance of early diagnosis and early treatment.
I intend to discover these factors in epidemiologic study through genetic and biological studies.
Professor Osamu Kaneko
http://www.tm.nagasaki-u.ac.jp/protozoology/eng/
http://www.researchgate.net/profile/Osamu_Kaneko2
Department of Protozoology, Institute of Tropical Medicine (NEKKEN), Nagasaki University, Japan.
Department of Medical Protozoology, Graduate School of Biomedical Sciences, Nagasaki University, Japan
I graduated from Osaka City University Medical School, Japan in 1990 and then trained as an Orthopedic Surgeon for 2 years. Following that, I decided to spend 4 years studying malaria in Osaka City University's Graduate School of Medicine. After I received my PhD, I worked in the Laboratory of Parasitic Diseases (Louis H. Miller Lab), NIAID, NIH, USA from 1997 to 1999. In 2000, I became a faculty member in the Department of Molecular Parasitology (Prof. Motomi Torii Lab), Ehime University School of Medicine, Japan and joined the Institute of Tropical Medicine, Nagasaki University as a full time professor in 2007. I was inspired to study malaria by the Prof. Kazuyuki Tanabe's lecture in 1986. For more details, please read my memoir of Kazuyuki Tanabe published in Paraisotl Int (2014).
School of Tropical Medicine and Global Health
I am responsible for lectures and practices on Medical Protozoology, including malaria, African trypanosomiasis (sleeping sickness), American trypanosomiasis (Chagas disease), leishmaniasis, and intestinal protozoan infections.
Other teachings at Nagasaki University
Training course of Tropical MedicineI am responsible for lectures and practices on Medical Protozoology.
Liberal arts Education "Safety and Security of the Medical Field"I give lectures on Medical Protozoology.
School of Medical Sciences, School of Medicine (Medical Microbiology and Parasitology)I give lectures and guide practices on Medical Protozoology.
Graduate School of Biomedical Sciences (Infectious Diseases)- I am responsible for lectures (Medical Parasitology) and thesis research in the Program for Nurturing Global Leaders in Tropical and Emerging Communicable Diseases (TECD).- I am responsible for seminars, practices, and thesis research in the Program alongside TECD.
Malaria is a huge burden and responsible for many deaths in large areas of the tropical and sub-tropical world. In order to design and implement effective disease intervention strategies, I believe that one of the key priorities in malaria research should be the strengthening of our understanding of the basic biology of the parasite. My team is currently investigating some fundamental aspects of the parasite's life cycle, such as the mechanisms behind red blood cell (RBC) invasion and the phenomenon of cytoadherence of parasite-infected RBCs using human malaria parasite Plasmodium falciparum, monkey malaria parasite P. knowlesi and rodent malaria parasite P. yoelii. I am also engaged in the field studies conducted in Thailand to understand the P. vivax biology in collaboration with Dr. Jetsumon Sattabongkot (Mahidol Vivax Research Center, Faculty of Tropical Medicine, Mahidol University, Thailand) and molecular epidemiology of P. falciparum in Kenya in collaboration with Prof. Akira Kaneko (Department of Parasitology, Osaka City University, Japan). Recently, we started to conduct a research to establish novel malaria model using ungulate malaria parasites.
RBC invasion by P. yoelii. Merozoite-stage parasite (arrowhead) invades into RBC within 30 seconds (0 – 25 s) and deformed RBC to spike-like shape (85 s). Recombinant protein (green) expressed in P. falciparum co-localized with Maurer's cleft protein (red) seen in the RBC cytosol outside of the malaria parasite. Nucleus is visualized with blue color.
Kegawa Y, Asada M, Ishizaki T, Yahata K, Kaneko O. Critical role of Erythrocyte Binding-Like protein of the rodent malaria parasite Plasmodium yoelii to establish an irreversible connection with the erythrocyte during invasion. Parasito Int (in press)
Asare KK, Sakaguchi M, Lucky AB, Asada M, Miyazaki S, Katakai Y, Kawai S, Song C, Murata K, Yahata K, Kaneko O. The Plasmodium knowlesi MAHRP2 ortholog localizes to structures connecting Sinton Mulligan's clefts in the infected erythrocyte. Parasitol Int 67:481-92. [Abstract]
Kaewthamasorn M, Takeda M, Saiwichai T, Gitaka JN, Tiawsirisup S, Imasato Y, Mossaad E, Sarani A, Kaewlamun W, Channumsin M, Chaiworakul S, Katepongpun W, Teeveerapunya S, Panthong J, Mureithi DK, Bawm S, Htun LL, Win MM, Ismail AA, Ibrahim AM, Suganuma K, Hakimi H, Nakao R, Katakura K, Asada M, Kaneko O. Genetic homogeneity of goat malaria parasites in Asia and Africa suggests their expansion with domestic goat host. Sci Rep 8:5827 [Abstract]
Templeton TJ, Asada M, Jiratanh M, Ishikawa SA, Tiawsirisup S, Sivakumar T, Namangala B, Takeda M, Mohkaew K, Ngamjituea S, Inoue N, Sugimoto C, Inagaki Y, Suzuki Y, Yokoyama N, Kaewthamasorn M, Kaneko O. Ungulate malaria parasites. Sci Rep 6:23230. [Abstract]
Pandey K, Ferreira PE, Ishikawa T, Nagai T, Kaneko O, Yahata K. Ca2+ monitoring in Plasmodium falciparumusing the yellow cameleon-Nano biosensor. Sci Rep 6:23454.[Abstract]
When I was a medical student, I visited many tropical and subtropical countries and recognized that infectious diseases were still huge burdens in the world. Then, one day in a parasitology class, I learned that the disease malaria was a major problem, and thereafter I was fascinated by malaria and its causative pathogen, Plasmodium. Now I am conducting research to elucidate the molecular mechanism of host cell invasion and modification mechanisms by this parasite, toward finding weak points to combat the disease malaria.
Professor Satoshi Kaneko
M.D.,M.P.H.,Ph.D
http://www.tm.nagasaki-u.ac.jp/nekken/english/research/eco-epidemiology.html
http://www.tm.nagasaki-u.ac.jp/multiplex/
Institute of Tropical Medicine, Nagasaki University
Visiting lecturer of Tohoku University
Visiting scientist of Osaka Kyoiku University
Associate Editor of Journal of Epidemiology
Councilor of Japanese Society of Tropical Medicine
JICA Consultant, Sri Lanka Non-communicable disease management project
Graduated from the National Defense Medical College, Saitama, Japan in 1990
JICA expert in the Tropical Disease Control Project for Chagas disease in Guatemala in 1995
Master of Public Health (MPH) degree from Harvard School of Public Health, Boston, Massachusetts, U.S.A in 1997.
PhD degree from the Graduate School of Medical Science, University of Occupational and Environmental Health, JAPAN (UOEH), Kitakyushu, JAPAN in 2001
Head of Cancer Surveillance Section, Statistics and Cancer Control Division in National Cancer Center, Tokyo from 2001 until 2005
Professor (Fixed-term) at Institute of Tropical Medicine, Nagasaki University since 2005 to present (Between 2006 and 2010, appointed at Nairobi Research Station, Nagasaki University)
Professor at Nagasaki University Graduate School of International Health Development since 2008 to present
Development of microsphere-based simultaneous multiple assays and surveillance systems for multiple infectious diseases in Africa.
Health and Demographic Surveillance System (HDSS) in Lao PDR.
Epidemiological studies for child health in Kenya.
Research on dengue prevention through a residential environmental clean-up program in Sri Lanka.
Finding malaria vaccine candidate antigens using microsphere-based simultaneous multiple assays.
A scientific approach to community-led total sanitation strategies in Africa.
Non-communicable disease (NCD) project by JICA in Sri Lanka.
Developing epidemiological data-collection tools using the cutting edge IT technology to monitor health-related problems in developing world; e.g., biometrics (vein authentication) to identify people and link different data sources (link: here)
Shinsugi C, Matsumura M, Karama M, Tanaka J, Changoma M, Kaneko S. Factors associated with stunting among children according to the level of food insecurity in the household: a cross-sectional study in a rural community of Southeastern Kenya. BMC public health 2015; 15(1): 441-51.(2015)
Fujii Y, Kaneko S, Nzou SM, Mwau M, Njenga SM, Tanigawa C, Kimotho J, Mwangi AW, Kiche I, Matsumoto S, Niki M, Osada-Oka M, Ichinose Y, Inoue M, Itoh M, Tachibana H, Ishii K, Tsuboi T, Yoshida LM, Mondal D, Haque R, Hamano S, Changoma M, Hoshi T, Kamo K, Karama M, Miura M, Hirayama K. Serological surveillance development for tropical infectious diseases using simultaneous microsphere-based multiplex assays and finite mixture models. PLoS neglected tropical diseases 2014 Jul; 8(7): e3040.(2014)
Miura M, Tanigawa C, Fujii Y, Kaneko S. Comparison of six commercially-available DNA polymerases for direct PCR. Rev Inst Med Trop Sao Paulo 2013 Nov-Dec; 55(6): 401-6.(2013)
Kaneko S, K'Opiyo J, Kiche I, Wanyua S, Goto K, Tanaka J, Changoma M, Ndemwa M, Komazawa O, Karama M, Moji K, Shimada M. Health and Demographic Surveillance System in the Western and Coastal Areas of Kenya: An Infrastructure for Epidemiologic Studies in Africa. J Epidemiol 2012 Feb 25; 22(3): 276-85.(2012)
Komazawa O, Kaneko S, K'Opiyo J, Kiche I, Wanyua S, Shimada M, Karama M. Are Long-Lasting Insecticidal Nets Effective for Preventing Childhood Deaths among Non-Net Users? A Community-Based Cohort Study in Western Kenya. PloS one 2012; 7(11): e49604.(2012)
Learn on site. Everything starts there. What are the problems? What do we need to solve them? In order for us to solve problems, we need "knowledge" and "tools." We also need to enthusiastically observe and dedicate ourselves to solving problems scientifically. Many of the problems we face do not have ready-made answers. This graduate course aims to establish a mechanism in which knowledge and tools from the "site" are applied to the "academic sphere," and vice versa. Together, we learn, practice, develop research, and return to practice. Let us embark on our quest for the unknown world!
Professor Yasuhiko Kamiya
M.D., M.Trop.Paed., PhD
https://www.researchgate.net/profile/Yasuhiko_Kamiya
Graduate School of Tropical Medicine & Global Health, Nagasaki University, Japan
Nagasaki University Graduate School of Biomedical Sciences
After acquiring MD. from Kochi Medical School in 1985, I worked for children with disability. I acquired Masters in Tropical Paediatrics from Liverpool School of Tropical Medicine in 1995, with the dissertation " Pneumocystis Pneumonia in HIV infected children in Malawi", and Ph.D. from Faculty of Medicine, University of Liverpool in 2002 with the thesis "Epidemiology and microbiology of acute respiratory infections in children in an urban poor area in Nairobi, Kenya and molecular epidemiology of RS virus". I joined vaccine trials for pertussis and measles in Ghana. I worked for humanitarian assistance in the former Yugoslavia, the former Zaire, Iraq, Afghanistan, Honduras and South Sudan with AMDA, Peace Wind Japan, UNHCR, and UNICEF. I have consulted and coordinated on community health, health system strengthening, epidemiology on infectious diseases and NCD in Sri Lanka, Kenya, Ghana, Fiji and Philippines and for local capacity development for health system research and epidemiology.
I will be teaching Global Health I, Child Health I, Child Health II, Community Health I, and Emergency Assistance I at the TMGH, and also supervising Long Term Internship for MPH course. Currently I am teaching child health and pediatric diseases in MTM and TTM courses, and current epidemiological transition and health system research at the phD Leading program. Previously I taught Overview of Global Health, Child Health, and Emergency Assistance at the Graduate School of International Health Development, along with supervision for long term internship for MPH students.
I have been studying aid effectiveness, particularly on aid fragmentation and its effect on health system. I participated in randomized control trials for several vaccines in Ghana, and did clinical and microbiological (molecular biological) study on RS virus and pneumocystis pneumonia in Malawi, cohort study for ARI in children in Kenya and NCD especially cardiovascular diseases and diabetes in Sri Lanka as well as research on referral system in Ghana, and supervision and health information system in Kenya along with overuse of antibiotics, disease replacement under polymicrobial status. I am also engaged in study on access and seeking behavior in children with disability in the Philippines.
Tsukakoshi T, Samuela J, Rafai EV, Rabuatoka U, Honda S, Kamiya Y, Buerano CC, Morita K. Hepatitis B serologic survey and review of immunization cords of children, adolescents and adults in Fiji, 2008–2009. Virology Journal 2015, 12:36
Kamiya Y. Epidemiology of infectious diseases in Africa in relation to polymicrobial replacement, urbanization, and control measures in health systems. Yves Charbit and Teiko Mishima (Eds.), Questions de migrations et de sante en Afrique Sub-saharienne (Issues of Migrations and Health in Sub-Saharan Africa). Recherches interdisciplinaires en France et au Japan. (pp. 187-213) 2014, Paris: L' Harmattan.
Masumoto S, Yamamoto T, Ohkado A, Yoshimatsu S, Querri AG, Kamiya Y. Prevalence and associated factors of depressive state among pulmonary tuberculosis patients in Manila, the Philippines. International Journal of Tubercle and Lung Disease. 2014. 18 (2) 174-179.
Masumoto S, Yamamoto T, Ohkado A, Yoshimatsu S, Querri AG, Kamiya Y.. Factors associated with health-related quality of life among pulmonary tuberculosis patients in Manila, the Philippines. Quality of Life Research 2014 Jun;23(5):1523-1533.
Sasaki E, Kamiya Y*. Caregivers' Understanding of Pediatric Medication in Central Malawi. J Trop Pediatr. doi: 10.1093/tropej/fmu057 2014.
In development assistance, you must clearly position yourself as to how you support and how much you intervene, while in humanitarian emergency aid, you must make difficult decisions promptly. The more you are involved, the more you realize the hollowness or limits of some approaches to international cooperation, the gap between ideals and reality, and the importance of learning from people in the field. To develop your capability along with those in the field, not necessarily solely for your career development, it is important to learn and un-learn some of what you have studied.
What is taught and learned in the classroom differs from what actually happens and is implemented. Sharing our failures and reflections in the field would be for beneficiaries, not for our carriers. This course offers the chance where we can continue our self-development together, with multifaceted perspectives and a critical regard for ourselves, while being aware of the privilege of mutually teaching and learning.
Professor Taro KIKUCHI
Bachelor of Economics from Waseda University, Japan
2017-, Current position
2015-2017, Director in the Health Group, Japan International Cooperation Agency (JICA) Headquarters, Tokyo, supervising the health sector cooperative technical and financial projects with health ministry of the government in the counties located in the South and Southeast Asia, responsible for the monitoring of JICA global health strategy under Japan's Official Development Assistance (ODA) policy on health, acting as the focal point of external relations in the areas of health and medicine with international financing institutions(e.g. the Asian Development Bank), United Nations Agencies (e.g. the World Health Organization), and global health initiatives(e.g. P4H Network for the Universal Health Coverage).
2013-2015, Senior Representative, JICA Tunisia Office, Tunis, appointed for the Assistant Country Director on behalf of JICA in Tunisia.
2010-2013, Advisor in the Health Group, JICA HQ, Tokyo, designing and managing the health sector assistances for some East Africa countries (including the technical cooperation of scientific research in partnership with the Nagasaki University in Kenya), planning and coordination of JICA's health cooperation directions in alignment with the global health trend, and acting as the first contact about the international health agendas especially targeting the Africa (e.g. emerging infectious diseases and zoonosis).
2008-2010, Assistant Director in the Africa Department, JICA HQ, Tokyo, managing the follow-up of the Fourth Tokyo International Conference on African Development(TICAD Ⅳ) and planning the process to TICAD Ⅴ in close collaboration with the Ministry of Foreign Affairs of Japan.
2005-2008, Representative in charge of health sector, JICA Zambia Office, Lusaka, coordinating the JICA's health-related activities ranging from Japanese health volunteers to technical cooperation under JICA country assistance strategy for Zambia, and serving as the Japan's focal in health for accelerating the aid harmonization for enhanced effectiveness with major health development partners present in Zambia(e.g. the United States Agency for International Development, U.K. Department for International Development, the World Bank, WHO).
1996-1998, Researcher, Grant Aid Division, Economic Cooperation Bureau, Ministry of Foreign Affairs, Tokyo, taking charge of humanitarian emergency assistances as Japan's ODA including disaster relief and aid to the refugees in the forms of food and medical commodities supply, and financial supports to the countries in the post-conflict and social reconstruction phase.
Foreign Aid Policy in health and facilitation of internships abroad.-Based on working experiences in the international development organization, theory of development assistance related to the global health issues, practical methods and administration in the management of bilateral cooperation under Japan's ODA are offered at classes.-Students who willingly take internship program at Japan's ODA projects are supported.
>Focuses on how much effectively Japan's ODA projects in the area of health is implemented and how much responsive they will be to the global health issues in the new era of the Sustainable Development Goals(SDGs)
Bangladesh, Myanmar, Lao PDR and Thailand(Asia)
Used to work for the health sector in Kenya and Zambia(Africa)
I am currently seconded from JICA (Japan International Cooperation Agency). The landscape around the global health is constantly dynamic. Timely response to the international heath always requires in-depth understanding of the discussion on the health challenges made at the global level and comprehension of the health policy framework developed at the national level. In addition, I suppose that international health professionals should outfitted with the competence to work out a plan on the field to sustainably ensure local people's health. Health and Medicine are the promising area of development cooperation where Japan ably makes great contribution. I am looking forward to cultivating study, at the Nagasaki University, together with the TMGH students who expectedly become the health professionals in the way to combine my own working experiences with the class lessons and practical trainings.
Professor Christopher Smith
MRCP, MRCGP, MSc, PhD, DTM&H (East African Partnership)
https://www.lshtm.ac.uk/aboutus/people/smith.christopher
https://www.linkedin.com/in/chris-smith-44580610/
Graduate School of Tropical Medicine and Global Health, Nagasaki University
Department of Clinical Research, Faculty of Infectious and Tropical Diseases, London School of Hygiene and Tropical Medicine
I have a joint position between the Department of Clinical Research at LSHTM and the graduate school of Tropical Medicine and Global Health (TMGH) at Nagasaki University since September 2017. I have been working at LSHTM since 2014, funded by a Medical Research Council Population Scientist Fellowship. My main area of research is in the field of digital health interventions to support sexual and reproductive health
I completed my PhD titled 'Increasing contraception use with mobile phone-based interventions' at LSHTM in 2017 which included a systematic review of mHealth interventions for contraception and the MObile Technology for Improved Family Planning (MOTIF) trial in partnership with Marie Stopes International in Cambodia.
Previously I completed the Public Health in Developing Countries MSc at LSHTM in 2011 as part of a National Institute of Health Research (NIHR) In-Practice Fellowship based at Imperial College London during 2010-12.
I work as a primary care medical doctor (GP) in London and have worked on an NHS project with Maddox Jolie-Pitt foundation in Cambodia and with Medecins Sans Frontieres in Uganda.
I co-organised the Family Planning programmes module (2401) at LSHTM for the last three years and teach at Nagasaki University. I supervise Masters and PhD students.
Interventions delivered by mobile phone (digital/mHealth); sexual and reproductive health; primary care; health partnerships.I am principal investigator on a project to develop an intervention to support reproductive health in Cambodia together with collaborators at SOAS, Kings College London and Marie Stopes International, funded by the Arts and Humanities Research Council (AHRC).Selected publications can be accessed here in addition to the list below. Please contact me for further information or if you are interested to discuss research or PhD projects.
Kuhlin J, Smith C, Khaemraev A, Tigay Z, Parpieva N, Tillyashaykhov M, Achar J, Hajek J, Greig J, du Cros P, Moore D. The impact of pyrazinamide resistance on multidrug-resistant tuberculosis in Karakalpakstan, Uzbekistan. The International Journal of Tuberculosis and Lung Disease. 2018;22(5):544-550
Smith C, Edwards P, Free C. Assessing the validity and reliability of self-report data on contraception use in the Mobile Technology for Improved Family Planning (MOTIF) randomised controlled trial. Reproductive Health. 2018;15:50
Smith C, Ngo T, Gold G, Edwards P, Vannak U, Sokhey L, Machiyama K, Slaymaker E, Warnock R, McCarthy O, Free C. Effect of a mobile phone-based intervention on post-abortion contraception: a randomized controlled trial in Cambodia. Bulletin of the World Health Organization. 2015.
Smith C, Gold J, Ngo T, Sumpter C, Free C. Mobile phone-based interventions for improving contraception use (Review). Cochrane Database Syst Rev. 2015;(6)
Smith C, Pettigrew L, Seo H, Dorwood J. Combining General Practice with International work: experiences of UK GPs. J R Soc Med Sh Rep. 2012;3(46):1-9
I am a clinical researcher with interests in different areas and experience of mixed methods research. I have worked as a primary care doctor in the UK and Uganda, where I recently completed the Professional Diploma in Tropical Medicine and Hygiene (DTM&H): East African partnership. My research has mainly been on digital health interventions for reproductive health, including a randomised controlled trial in Cambodia. Please contact me for further information or if you are interested to discuss research or PhD projects.
Professor Isao SHIMOKAWA
Professor Sharon Cox
BSc, MSc, PhD
http://www.lshtm.ac.uk/aboutus/people/cox.sharon
https://www.researchgate.net/profile/Sharon_Cox
Twitter account name
@sharonecox15
School of Tropical Medicine and Global Health, Nagasaki University, Japan
London School of Hygiene and Tropical Medicine, London, UK
I graduated from University College London with a BSc. (Biochemistry, First Class Hons) in 1996, followed by a postgraduate teaching qualification (1997), a Masters in Public Health Nutrition at the London School of Hygiene & Tropical Medicine [LSHTM] (1998) and finally a PhD, also at LSHTM (2003). My PhD comprised a clinical trial of low-dose maternal vitamin A supplementation to determine effects on immunity to malaria in pregnancy in Ghana. In 2002 I became a staff member at LSHTM within the MRC International Nutrition Group and worked on malaria and anemia in Gambian children. In 2007 I moved to be based in Dar es Salaam Tanzania, working mostly on sickle cell disease. In 2015 I was appointed as a Professor at School of Tropical Medicine & Global Health, Nagasaki University, where I am now based. I also hold a joint appointment at LSHTM.
I co-organise courses in Epidemiology and Statistics in semesters 1 and 3 for the TMGH MSc courses. These courses are based on those provided by the London School of Hygiene & Tropical Medicine masters programmes and are taught by Nagasaki and visiting LSHTM research staff. I also organise a module on Nutrition for Global Health in Semester 3 and teach individual sessions on in other modules on effects of both under and over-nutrition, diagnosis and management of acute malnutrition, nutrition and infection, causes and effects of anaemia in the tropics, epidemiology and field-based research methodology
Previously at the London School of Hygiene & Tropical Medicine, UK I taught and managed units within the MSc in Public Health Nutrition and I have been a tutor on distance based learning MSc courses: "Nutrition and Infection" & "Study Design: writing a grant application.
I am interested in how nutrition underpins human health and in particular in relation to interactions with infections, other conditions like sickle cell disease and maternal and child health. My research aims to provide an evidence base to support nutrition-based interventions to improve health outcomes in populations in low and middle income countries.
Current ongoing studies are summarized below:
Nutrition and TB
I am leading research on nutrition and diabetes in TB patients in the Philippines in both inpatient and outpatient populations in Metro Manila, Cebu and Negros Occidental. I collaborate with investigators from San Lazaro Hospital, Manila, the Nutrition Centre, Philippines and the National TB programme.
Malnutrition in children
In Nepal I am leading research assessing malnutrition in pediatric admissions and outpatient clinics (children of all ages). In Cambodia, we are investigating the determinants of malnutrition of young children within the NHAM birth cohort, with a focus on infections and the microbiome. In Burundi we are collaborating with Action Against Hunger to evaluate malnutrition diagnosis and referral within the integrated community case based management programme (iCCM).
Nutrition as a modulator of sickle cell disease
Within the Muhimbili Sickle Cohort in Tanzania, my previous research has focused on nutritional and genetic modulation of sickle cell disease (SCD).
Epidemiology, Nutrition, Maternal and child health, infectious diseases
Nutrition and hypertension/vascular function and role of infections, interactions between diabetes and infections.
The Philippines, Nepal, Bangladesh, Cambodia, UK, Japan, Tanzania, Kenya, The Gambia, India
Lee N, Makani J, Tluway F, Makubi A, Armitage AE, Pasricha SR, Drakesmith A, Prentice AM & Cox SE. Decreased hepcidin levels are associated with low steady-state hemoglobin in children in the Muhimbili sickle cohort, Tanzania. EBioMed, 2018. In press
Cox SE, Ellins EA, Marealle AI, Newton CR, Soka D, Sasi P, Di Tanna GL, Johnson W, Makani J, Prentice AM, Halcox JP & Kirkham FJ. Ready-to-use food supplement +/- arginine & citrulline with daily chloroquine in Tanzanian children with sickle cell disease: a double blind random order cross-over trial. Lancet Hematology, 2018 In press –
Yamanashi H, Kulkarni B, Edwards T, Kinra S, Koyamatsu J, Nagayoshi M, Shimizu Y, Maeda T & Cox SE. Association between atherosclerosis and handgrip strength in non-hypertensive populations in India and Japan. Geriatrics & Gerontology International, in press –
Marealle AI, Siervo M, Wassel S, Bluck L, Prentice AM, Minzi O, Sasi P, Kamuhabwa A, Soka D, Makani J, Cox SE. A pilot study of a non-invasive oral nitrate stable isotopic method suggests that arginine and citrulline supplementation increases whole-body NO production in Tanzanian children with sickle cell disease. Nitric Oxide. 2018 Jan 2;74:19-22. doi: 10.1016/j.niox.2017.12.009. [Epub ahead of print]
Nkya S, Mgaya J, Urio F, Makubi A, Thein SL, Menzel S, Cox SE, Newton CR, Kirkham FJ, Mmbando BP, Makani J. Fetal Hemoglobin is Associated with Peripheral Oxygen Saturation in Sickle Cell Disease in Tanzania. EBioMedicine. 2017 Sep;23:146-149. doi: 10.1016/j.ebiom.2017.08.006. Epub 2017 Aug 8.
Link to all publications
http://www.ncbi.nlm.nih.gov/sites/myncbi/1tmZEPnoXym/bibliography/40021911/public/?sort=date&direction=decendinga
I propose that nutrition is one of the most important modifiable environmental factors underlying health and disease. Along with infections such as malaria, nutrition has been one of the strongest selection pressures over our recent evolutionary history. This has significant implications in relation to the rapid changes in diet and lifestyle that are occurring globally. Under and over-nutrition are increasingly occurring within the same population groups and in both low and high-income countries.
Nutrition is essential to consider at individual and community/population levels in order to ensure that health interventions are optimally successful.
My research focuses on understanding the mechanisms by which nutritional factors affect health outcomes, with a focus on low- and middle-income country settings and encompassing infectious and non-infectious disease processes.
Professor Juntra Karbwang Laothavorn
MD, DTM&H, PhD
https://www.researchgate.net/profile/Juntra_Karbwang
Thammasat University, Bangkok, Thailand
FERCAP, Bangkok, Thailand
Juntra Karbwang Laothavorn MD, DTM&H, PhD has been a part of the Institution of Tropical Medicine, Nagasaki University, as Professor and Head of Clinical Product Development Department since April, 2012. Her responsibility is to develop a mechanism and system for NEKKEN Clinical Health Product (drug/vaccine) development.
Prior to joining NEKKEN, she spent 14 years (1998-2012) at the World Health Organization's Special Program on Tropical Disease Research (WHO/TDR) in Geneva, Switzerland. She has produced a series of Standard Operating Procedures for WHO/TDR clinical investigators and clinical monitors, and coordinated the production of WHO Operational Guidelines for Ethics Committees That Review Biomedical Research (translated into more than 20 languages).
She spent 17 years (1981-1998) at the Tropical Research Institute, Mahidol University in Bangkok, Thailand. Her last appointment was Professor of Clinical Tropical Medicine and Head of Clinical Tropical Pharmacology Unit. Her academic research was concentrated on the Clinical Pharmacology of antimalarials. She has published more than 140 original articles widely on clinical development of drugs for Tropical Diseases.
Co-director of Conducting Responsible Research for TMGH
Course director for Clinical Tropical Pharmacology at the Institution of Tropical Medicine, Mahidol University, Bangkok, Thailand (1981-1998)
Developed training curricula for clinical monitors, clinical investigators and members of ethics committee in African and Asian countries (1998-2012).
Developed curriculum for short training course in Product Research and Development in 2005 and teach annually on one module in good clinical practice at NEKKEN.
Development of innovative method for enhanced informed consent form in clinical research (supported by WHO/TDR)
Assessment of the quality of Ethical Review for Clinical Research in Asia (Supported by WHO/TDR and FERCAP – www. FERCAP-SIDCER.org)
Development of Shiunko ointment for Cutaneous Leishmaniasis
Development of Khod Kamoa (herbal medicine) for Cholangiocarcinoma (in collaboration with Thammasat university and the Thai Government Pharmaceutical Organization)
Nut Koonrungsesomboon, Supanimit Teekachunhatean, Nutthiya Hanprasertpong, Junjira Laothavorn, Kesara Na-Bangchang & Juntra Karbwang (2016). Improved participants' understanding in a healthy volunteer study using the SIDCER informed consent form:a randomized-controlled study. Dur J Clin Pharmacol 72:413-421
Kesara Na-Bangchang, Oumer Ahmed, Jemal Hussein, Kenji Hirayama, Panida Kongjam, Abraham Aseffa, and Juntra Karbwang (2016). Exploratory, Phase II Controlled Trial of Shiunko Ointment Local Application Twice a Day for 4 Weeks in Ethiopian Patients with Localized Cutaneous Leishmaniasis Evidence-Based Complementary and Alternative Medicine http://dx.doi.org/10.1155/2016/5984709
Nut Koonrungsesomboon, Kesara Na-Bangchang, Juntra Karbwang. (2014) Therapeutic potential and pharmacological activities of Atractylodes lancea (Thunb.) DC. Asian Pacific Journal of Tropical Medicine, 412-420 Doi:10.1016/s1995-7645(14)60069-9
Tullayakorn Plengsuriyakarn, Veerachai Thitapakorn, Kesara Na-Bangchang, Juntra Karbwang (2013). Thai Medicinal plants: Potential sources of anticholangiocarcinoma drugs. International Journal of Pharmacy and Pharmacology. 2(5), 068-082
Juntra Karbwang and Kesara NaBangchang (2013) Practical Application of International Standards and Guidelines to Address Ethical Challenges in Clinical Trials. J Clinical Res Bioeth 4: 144. doi:10.4172/2155-9627.1000144
Conducting responsible research is more than the desire to do the right thing. It is crucial that students recognize and appreciate the wide range of good practices in conducting research and publication. It is important that the students act responsibly to these standards throughout research processes. This training course addresses the topics of responsible research, good research practice, standards for development of protocol, data management and publication of research results. The training will elaborate required acceptable practices for achieving excellence in research across all fields and disciplines. The lectures will be complemented by examples and exercises, so that students have opportunities to apply the principles into practices.
Professor Noriyuki Nishida
MD.PhD.
http://www.med.nagasaki-u.ac.jp/mmi/cmb/index_e.html
We focus on I was born in Fukuoka, Japan 1965, and studied medicine at Ryukyu University School of Medicine. I have studied about most mysterious infectious agent, prion, since 1995 in Japan, France, and US. From 2009, I am leading my team as a professor in Nagasaki University Graduate School of Biomedical Sciences.
Molecular medicine about prion diseases
We focus on drug-discovery for prion diseases, developing a new diagnostic method, analysis of host-pathogen relationship, and autophagy.
Collaborating with research group of neurosurgeons, we are studying the possibility of the stem-cell transplantation for neurological disorders too.
Recently, we have developed a new in vitro amplifying method of PrPSc (real-time Quaking Induce Conversion: RT-QuIC). We applied this amplification technique to detect small amounts of PrPSc in patient's CSF and established as a diagnostic test of human prion diseases.
Hanae Takatsuki, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Takehiro Nakagaki, Tsuyoshi Mori, Daisuke Ishibashi, Ban Mihara, Masaki Takao, Yasushi Iwasaki, Mari Yoshida, Ryuichiro Atarashi, Noriyuki Nishida: Rapid and Quantitative Assay of Amyloid-Seeding Activity in Human Brains Affected with Prion Diseases. PLoS ONE 06/2015; 10(6):e0126930. DOI:10.1371/journal.pone.0126930
Kazunori Sano, Ryuichiro Atarashi, Daisuke Ishibashi, Takehiro Nakagaki, Katsuya Satoh, Noriyuki Nishida: Conformational Properties of Prion Strains Can Be Transmitted to Recombinant Prion Protein Fibrils in Real-Time Quaking-Induced Conversion. Journal of Virology 07/2014; 88(20). DOI:10.1128/JVI.00585-14
Takehiro Nakagaki, Katsuya Satoh, Daisuke Ishibashi, Takayuki Fuse, Kazunori Sano, Yuji O Kamatari, Kazuo Kuwata, Kazuto Shigematsu, Yoshifumi Iwamaru, Takato Takenouchi, Hiroshi Kitani, Noriyuki Nishida, Ryuichiro Atarashi: FK506 reduces abnormal prion protein through the activation of autolysosomal degradation and prolongs survival in prion-infected mice. Autophagy 06/2013; 9(9). DOI:10.4161/auto.25381
Daisuke Ishibashi, Ryuichiro Atarashi, Takayuki Fuse, Takehiro Nakagaki, Naohiro Yamaguchi, Katsuya Satoh, Kenya Honda, Noriyuki Nishida: Protective Role of Interferon Regulatory Factor 3-Mediated Signaling against Prion Infection. Journal of Virology 02/2012; 86(9):4947-55. DOI:10.1128/JVI.06326-11
Ryuichiro Atarashi, Katsuya Satoh, Kazunori Sano, Takayuki Fuse, Naohiro Yamaguchi, Daisuke Ishibashi, Takehiro Matsubara, Takehiro Nakagaki, Hitoki Yamanaka, Susumu Shirabe, Masahito Yamada, Hidehiro Mizusawa, Tetsuyuki Kitamoto, Genevieve Klug, Amelia McGlade, Steven J Collins, Noriyuki Nishida: Ultrasensitive human prion detection in cerebrospinal fluid by real-time quaking-induced conversion. Nature medicine 02/2011; 17(2):175-8. DOI:10.1038/nm.2294
I specialize in prion disease, a 100% fatal infectious disease, which is said to be the most miserable disease for humankind. Prion encompasses various aspects including infectious protein, pathogens without genes, contagious dementia, amyloidosis, and zoonosis, which require cross-sectoral research approaches. The development of BSE relates to the problems of food safety, and many people may still remember this disease causing international issues in terms of import control. In the lectures, I plan to examine the meaning of the existence of "infectious protein" in pathogenic microorganisms through discussion, while learning the history of prion discovery and identification of the pathogen.


Spillis Candela was one of the first firms in Miami to acknowledge the cultural and historical roots of that locale. This volume focuses on the firms work of the last 10 years.
Multinational Enterprise And World Competition Multinational firms are often seen as controlling the secrets of industrial success, and conversely, as causing industrial decline. As a consequence their activities are the subject of debate. This study assesses the role of multinational enterprise in international competition and analyses the implications that follow for policy formulation.


What is Shorehammer's AoS Grand Tournament?
First come, first serve so buy yo ticket bruh.
We are totaling all VPs earned during all games, plus 3 extra VPs for a Major Victory and 2 extra VP for a Minor Victory. All Victory Points a player has earned will be tallied up and the winners are decided using the highest scores.
At the end of the third game, each player will secretly write down the name of the player that was the most fun to play against. Ties will be broken by which player (if either) was chosen as an opponent's favorite, and further ties will be broken by which army is most completely painted and based.
Each player should come with a 1500 point army chosen from a single alliance (Order, Chaos, Destruction or Death) using the points in the current General's Handbook.
Forge World is NOT allowed.
Only 2 Warscroll Battalions is allowed per list.
All rules will be taken from the Matched Play section of the most current edition of the General's Handbook.
If a unit has two keywords, (ex: Leader and Behemoth) it counts as both for the list requirements.
IMPORTANT: Flesh Eater Courts Royal Terrorgheists and Royal Zombie Dragons for a Grislegore army have the Behemoth keyword despite the FAQ.


Full length 10.5 oz light weight wool kilted skirt in Cornish Hunting tartan. Made to measure to a m..
Classic Cornish Hunting kilted skirt. Made to measure in 10.5 oz light weight wool, to a maximum l..
Cornish Hunting mini kilted skirt. Made to measure in 10.5 oz light weight wool, to a maximum leng..
Cornish Hunting tartan brushed lambswool scarf, measuring 30x150cm (12" x 58") with fringed ends, th..
Made to measure hand stitched heavy weight kilt with a minimum 8 yards of 16oz Cornish Hunting wool ..
Made to measure machine stitched heavy weight kilt with a minimum 4 yards of 16oz Cornish Hunting wo..
Cornish Hunting tartan square border shawl fringed on all edges, manufactured in the UK from 100% Sp..
Cornish Hunting tartan wool cummerbund. Pleated front wool cummerbund with adjustment at the back. T..
Ladies Cornish Hunting tartan wool sash 230cm x 28cm (90" x 11"). A flexible addition to your wardro..
Cornish Hunting tartan wool county cap, manufactured in the UK from light weight wool cloth. The fit..


text:
Amperometric glucose biosensor based on glucose oxidase encapsulated in carbon nanotube-titania-Nafion composite film on platinized glassy carbon electrode
Han, N. C., Jee, H. H., Ji, A. P., Joong, M. L. & Lee, W. Y., 2007 Sep, In: Electroanalysis. 19, 17, p. 1757-1763 7 p.
Amperometric tyrosinase biosensor based on carbon nanotube-titania-Nafion composite film
Lee, Y. J., Lyu, Y. K., Han, N. C. & Lee, W. Y., 2007 May, In: Electroanalysis. 19, 10, p. 1048-1054 7 p.
A multi-dimensional indexing approach for timestamped event sequence matching
Park, S., Won, J. I., Yoon, J. H. & Kim, S. W., 2007 Nov 15, In: Information sciences. 177, 22, p. 4859-4876 18 p.
A multi-hop user admission algorithm for fixed relay stations with limited capabilities in OFDMA cellular networks
Lee, J., Wang, H., Lim, S. & Hong, D., 2007, 18th Annual IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, PIMRC'07. 4394542. (IEEE International Symposium on Personal, Indoor and Mobile Radio Communications, PIMRC).
A multiscale mortar mixed finite element method for slightly compressible flows in porous media
Kim, M. Y., Park, E. J., Thomas, S. G. & Wheeler, M. F., 2007 Sep, In: Journal of the Korean Mathematical Society. 44, 5, p. 1103-1119 17 p.
An adaptive materialization method for globally optimized query evaluation in a hierarchical mediator system
Joo, K. H. & Lee, W. S., 2007 Jan, In: Computer Journal. 50, 1, p. 68-80 13 p.
An agent system for B2B EC in ubiquitous environment: AgentU
Lim, G. G., Yoo, W. S. & Lee, J., 2007, 2007 International Conference on Convergence Information Technology, ICCIT 2007. p. 535-540 6 p. 4420314. (2007 International Conference on Convergence Information Technology, ICCIT 2007).
An algorithm for forest stem volume retrieval under the condition of limited auxiliary information
Kononov, A. A. & Ka, M. H., 2007, 2007 International Conference on Convergence Information Technology, ICCIT 2007. p. 541-548 8 p. 4420315. (2007 International Conference on Convergence Information Technology, ICCIT 2007).
An alternative least-squares formulation of the Navier-Stokes equations with improved mass conservation
Heys, J. J., Lee, E., Manteuffel, T. A. & McCormick, S. F., 2007 Sep 10, In: Journal of Computational Physics. 226, 1, p. 994-1006 13 p.
Analternative mechanism for the cognitive fit theory in spreadsheet analysis
Chan, H. C., Kim, H. W. & Goswami, S., 2007.
Analysis and implementation of 3-D FDTD method based on isotropic dispersion scheme
Kim, W. T., Kim, H., Koh, I. S. & Yook, J. G., 2007, 2007 Workshop on Computational Electromagnetics in Time-Domain, CEM-TD. 4373544. (2007 Workshop on Computational Electromagnetics in Time-Domain, CEM-TD).
Analysis of adrenal masses by 18F-FDG positron emission tomography scanning
Han, S. J., Kim, T. S., Jeon, S. W., Jeong, S. J., Yun, M., Rhee, Y., Kang, E. S., Cha, B. S., Lee, E. J., Lee, H. C. & Lim, S. K., 2007 May, In: International Journal of Clinical Practice. 61, 5, p. 802-809 8 p.
Analysis of a joint method between superconducting YBCO coated conductors
Park, D. K., Ahn, M. C., Kim, H. M., Lee, H. G., Chang, K. S., Lee, S. J., Yang, S. E. & Ko, T. K., 2007 Jun, In: IEEE Transactions on Applied Superconductivity. 17, 2, p. 3266-3269 4 p.
Analysis of chromosomal changes in serous ovarian carcinoma using high-resolution array comparative genomic hybridization: Potential predictive markers of chemoresistant disease
Kim, S. W., Kim, J. W., Kim, Y. T., Kim, J. H., Kim, S., Yoon, B. S., Nam, E. J. & Kim, H. Y., 2007 Jan, In: Genes Chromosomes and Cancer. 46, 1, p. 1-9 9 p.
Analysis of design approaches to improve the comfort level of a small glazed-envelope building during summer
Kim, K., Kim, B. S. & Park, S., 2007 Jan, In: Solar Energy. 81, 1, p. 39-51 13 p.
Analysis of facial sebum distribution using a digital fluorescent imaging system
Han, B., Jung, B., Nelson, J. S. & Choi, E. H., 2007 Jan, In: Journal of Biomedical Optics. 12, 1, 014006.
Analysis of human V-erbA related EAR-3 gene expression between transitional cell carcinoma and normal tissue in bladder cancer
Han, W. S., Lee, J. H., Yu, H. S. & Choi, Y. D., 2007 Sep, In: Korean Journal of Urology. 48, 9, p. 915-920 6 p.
Analysis of injection molding to fabricate patterned media with nano pillars
Choi, M., Lee, N., Han, J., Hong, J. & Kang, S., 2007, p. 2018-2022. 5 p.
Analysis of meridians potential as ground condition for objectification of acupuncture effect
Lee, Y. H., Lee, Q. J., Kim, E. G., Kim, H. S. & Shin, T. M., 2007, In: Transactions of the Korean Institute of Electrical Engineers. 56, 2, p. 436-441 6 p.
Analysis of MPLS Signaling Protocols and Traffic Dissemination in OSPF and MPLS
Kim, S. C. & Chung, J. M., 2007, Proceedings - 1st Asia International Conference on Modelling and Simulation: Asia Modelling Symposium 2007, AMS 2007. Al-Dabass, D., Zobel, R., Abraham, A. & Turner, S. (eds.). Institute of Electrical and Electronics Engineers Inc., p. 276-281 6 p. 4148672. (Proceedings - 1st Asia International Conference on Modelling and Simulation: Asia Modelling Symposium 2007, AMS 2007).
Analysis of nanowire-based localized surface plasmon resonance using an effective medium theory
Yoon, S. J. & Kim, D., 2007, Conference on Lasers and Electro-Optics/Pacific Rim, CLEOPR 2007. Optical Society of America, (Optics InfoBase Conference Papers).
Yoon, S. J. & Kim, D., 2007, 2007 Conference on Lasers and Electro-Optics - Pacific Rim, CLEO/PACIFIC RIM. 4391356. (Pacific Rim Conference on Lasers and Electro-Optics, CLEO - Technical Digest).
Analysis of nonlinear frequency sweep in high-speed tunable laser sources using a self-homodyne measurement and Hilbert transformation
Ahn, T. J. & Kim, D. Y., 2007 May 1, In: Applied Optics. 46, 13, p. 2394-2400 7 p.
Analysis of the operational characteristics of a resistive SFCL by using the YBCO coated conductor
Park, D. K., Yang, S. E., Yoon, Y. S., Ahn, M. C., Kim, H. M., Kim, Y. S., Park, J. W. & Ko, T. K., 2007 Jun, In: IEEE Transactions on Applied Superconductivity. 17, 2, p. 1851-1854 4 p.
Analysis on effect of external shock in near-field recording system
Yoon, Y. J., Kim, S. H., Seol, W., Kim, J. G., Park, N. C. & Yang, H., 2007 Jun 22, In: Japanese Journal of Applied Physics, Part 1: Regular Papers and Short Notes and Review Papers. 46, 6 B, p. 3997-4002 6 p.
Analytical model development for the prediction of the frictional resistance of a capsule endoscope inside an intestine
Kim, J. S., Sung, I. H., Kim, Y. T., Kim, D. E. & Jang, Y. H., 2007, In: Proceedings of the Institution of Mechanical Engineers, Part H: Journal of Engineering in Medicine. 221, 8, p. 837-845 9 p.
Analytical models for assessment of the safety of multi-span steel beams based on average strains from long gage optic sensors
Park, H. S., Jung, S. M., Lee, H. M., Kwon, Y. H. & Seo, J. H., 2007 Jun 12, In: Sensors and Actuators, A: Physical. 137, 1, p. 6-12 7 p.
Analytical solution to optimal relocation of satellite formation flying in arbitrary elliptic orbits
Cho, H. C., Park, S. Y., Yoo, S. M. & Choi, K. H., 2007, American Astronautical Society - Space Flight Mechanics 2007 - Advances in the Astronautical Sciences, Proceedings of the AAS/AIAA Space Flight Mechanics Meeting. p. 153-179 27 p. (Advances in the Astronautical Sciences; vol. 127 PART 1).
Analyzing the impact of sloan digital sky survey on astronomical literature: A multiple perspective approach
Zhang, J., Zhu, W., Chen, Y., Vogeley, M. & Chen, C., 2007, p. 964-965. 2 p.
An analytical investigation of thermal prestressing method for continuous composite girder bridges
Kim, S. H., Kim, J. H., Ahn, J. H. & Song, H. W., 2007 Apr, In: Magazine of Concrete Research. 59, 3, p. 165-178 14 p.
An anatomic assessment on perforators of the lateral circumflex femoral artery for anterolateral thigh flap
Choi, S. W., Park, J. Y., Hur, M. S., Park, H. D., Kang, H. J., Hu, K. S. & Kim, H. J., 2007 Jul, In: Journal of Craniofacial Surgery. 18, 4, p. 866-871 6 p.
An approximate formula to calculate the fundamental period of a fixed-free mass-spring system with varying mass and stiffness
Kim, J., Collins, K. R. & Lim, Y. M., 2007 Apr 20, In: Structural Engineering and Mechanics. 25, 6, p. 717-732 16 p.
An assessment of sampling, preservation, and analytical procedures for arsenic speciation in potentially contaminated waters
Kim, Y. T., Yoon, H., Yoon, C. & Woo, N. C., 2007 Aug, In: Environmental Geochemistry and Health. 29, 4, p. 337-346 10 p.
An association between RRM1 haplotype and gemcitabine-induced neutropenia in breast cancer patients
Sun, Y. R., Hei, C. J., Yeon, H. C., Woo, I. Y., Jin, H. Y., Byung, S. K., Jae, K. R. & Hyun, C. C., 2007 Jun, In: Oncologist. 12, 6, p. 622-630 9 p.
An automated composition of information web services based on functional semantics
Shin, D. H. & Lee, K. H., 2007, Proceedings - 2007 IEEE Congress on Services, SERVICES 2007. p. 300-307 8 p. 4278811. (Proceedings - 2007 IEEE Congress on Services, SERVICES 2007).
An automated generation of XForms interfaces for Web services
Song, K. & Lee, K. H., 2007, Proceedings - 2007 IEEE International Conference on Web Services, ICWS 2007. p. 856-863 8 p. 4279681. (Proceedings - 2007 IEEE International Conference on Web Services, ICWS 2007).
An effective bump mapping hardware architecture using polar coordinate system
Lee, S. G., Park, W. C., Lee, W. J., Yang, S. B. & Han, T. D., 2007 Mar, In: Journal of Information Science and Engineering. 23, 2, p. 569-588 20 p.
An effective threshold-based neighbor selection in collaborative filtering
Kim, T. H. & Yang, S. B., 2007, Advances in Information Retrieval - 29th European Conference on IR Research, ECIR 2007, Proceedings. Springer Verlag, p. 712-715 4 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 4425 LNCS).
An efficient channel estimation algorithm under narrow-band jamming for OFDM systems
Myeongsu, H., Takki, Y., Jihyung, K., Kyungchul, K., Seungyoup, H. & Daesik, H., 2007, Military Communications Conference 2006, MILCOM 2006. 4086726. (Proceedings - IEEE Military Communications Conference MILCOM).
An efficient code-timing acquisition for MIMO-CDMA systems
Kwon, Y., Shin, M., Kim, K. H. & Lee, C., 2007 Sep, In: IEEE Transactions on Vehicular Technology. 56, 5, p. 2954-2964 11 p.
An efficient CQI feedback scheme for multiuser MIMO systems
Cho, M. G., Kim, Y., Kim, Y. & Hong, D., 2007, 2007 IEEE 66th Vehicular Technology Conference, VTC 2007-Fall. p. 625-629 5 p. 4349790. (IEEE Vehicular Technology Conference).
An efficient location encoding method for moving objects using hierarchical administrative district and road network
Lee, S. Y., Park, S., Kim, W. C. & Lee, D., 2007 Feb 1, In: Information sciences. 177, 3, p. 832-843 12 p.
An efficient management algorithm for gateway readers in the warehouse
Son, B. K., Lee, J. H., Park, K. L. & Kim, S. D., 2007, Proceedings - 2007 International Conference on Multimedia and Ubiquitous Engineering, MUE 2007. p. 130-134 5 p. 4197262. (Proceedings - 2007 International Conference on Multimedia and Ubiquitous Engineering, MUE 2007).
An efficient method to create business level events using complex event processing based on RFID standards
Son, B. K., Lee, J. H., Park, K. L., Kim, C. G., Kim, H. C. & Kim, S. D., 2007, Software Technologies for Embedded and Ubiquitous Systems - 5th IFIP WG 10.2 International Workshop, SEUS 2007, Revised Papers. Obermaisser, R., Puschner, P., Nah, Y. & Rammig, P. (eds.). Springer Verlag, p. 1-10 10 p. (Lecture Notes in Computer Science (including subseries Lecture Notes in Artificial Intelligence and Lecture Notes in Bioinformatics); vol. 4761 LNCS).
An efficient MIMO receiver for full-diversity full-rate space-time code
Jaesang, H., Byungwook, Y. & Chungyong, L., 2007, IEEE GLOBECOM 2007 - 2007 IEEE Global Telecommunications Conference, Proceedings. p. 3529-3532 4 p. 4411580. (GLOBECOM - IEEE Global Telecommunications Conference).
An efficient multi-mode precoding for MIMO systems with full CSI
Shin, M., Kim, S., Kang, J. & Lee, C., 2007, In: IEICE Transactions on Communications. E90-B, 10, p. 2973-2975 3 p.
An efficient policy establishment scheme for web services migration
Kim, Y. S. & Lee, K. H., 2007, 2007 International Conference on Convergence Information Technology, ICCIT 2007. p. 595-600 6 p. 4420324. (2007 International Conference on Convergence Information Technology, ICCIT 2007).
An efficient scalable and hybrid arithmetic unit for public key cryptographic applications
Yu, S. J., Kim, M. G., Heo, S. W., Song, J. S. & Lee, Y. S., 2007 Jul 25, In: ieice electronics express. 4, 14, p. 461-466 6 p.
A negentropy minimization approach to adaptive beamforming assisted receivers
Choi, S. & Chung, J. M., 2007, In: IEICE Transactions on Communications. E90-B, 11, p. 3283-3286 4 p.
An empirical analysis of nonstationarity in a panel of interest rates with factors
Moon, H. R. & Perron, B., 2007 Mar, In: Journal of Applied Econometrics. 22, 2, p. 383-400 18 p.

redpajama_set_name: RedPajamaCommonCrawl


Cleaning a custom tile shower system can be a challenge. Repairing a shower pan leak requires to know how and experience.
A properly designed and constructed tile shower is a beautiful thing. It adds beauty and elegance to a home or a commercial building.
A shower helps to relieve the stress of a hard day or to hide away whenever you have to or want privacy.
With over 17 years in cleaning, sealing, repair and installing custom tile shower system, we will answer each one o these ones by one.
The first thing we want to discuss is how to keep the shower clean in order to avoid or reduce the amount of soiling in your tile shower.
Keep your shower dry – it is recommended that you have a properly working exhaust fan installed in your bathroom. The fan not only fan-out the musty orders but also the humidity from showering. It is recommended that you run the fan for at least 30 minutes after every shower, keep the shower door or curtains open to allow air to circulate.
Use a squeegee to squeegee down the wall and glass in the shower after every use. Again, this helps keep the shower dry.
Use a penetrating sealer to seal the grout lines and floor every couple of years. Sealing the grout lines or natural stone tiles prevent water or moisture entering the surfaces. This will help keep the shower clean.
The two major soiling reasons are soaps and mildew.
Some soaps and shampoos are heavy in soap and will leave a residue after every shower. This residue will build up after a while making the shower walls and floor look dingy. If you have porcelain or ceramic tile, we use a razor blade to remove the gross build up and finish cleaning with a high alkaline cleaning solution and a gentle scrubbing pad.
Mildew or mold – These fungi grow in dark, damp and warm areas. Once they are allowed to spread, it is very difficult to clean. Most people use a mix of bleach and water to kill the fungi. If you see signs of black mold, it is recommended to seek the help of a professional.
To clean grout lines, use a high alkaline cleaner and a grout brush to scrub the cleaning solution into the grout lines. The use of a steam cleaner will make cleaning the shower grout lines easier and more effective.
2. What are the best shower cleaning products?
When selecting an effective cleaning product for your shower, consider the source or cause of the soiling. In the shower, you will find heavy soap build up combined with body oils and other organic soilings.
Whenever we are trying to clean an oil-based stain or soil, we must use a degreaser. For homemade porcelain or ceramic shower tile and grout cleaning, you can use a mix of vinegar and dishwashing liquid, spray it in the affected area, let it dwell and then scrub with a soft brush or white scrubbing pad. Follow this by rinsing thoroughly. Caution: this mix is not safe for natural stone tiles.
3. How to repair damaged or broken grout lines in the shower.
Best way to repair those broken grout lines is to scrape the damaged grout line and replace with new grout. This depends on several factors.
The width of the grout lines and type of grout lines. If you have thick grout lines, you can use a box cutter knife to scrape the lines. If the grout lines are thicker, then a grout scrapper will do very nicely.
The type of grout. Grout is normally found in sanded or unsanded. If you have thin grout lines, you probably have unsanded grout. Ensure that you use the correct type when replacing the grout.
4. What is the cost of replacing or regrouting a shower?
Obviously, this can vary from region to region, size of the shower, amount of grout, size of grout lines and depending on the experience and size of the grout repair company or contractor.
Most contractors will charge by the hour or the job.
This is and can be the most troublesome. There are several causes and areas for shower floor leaks.
Type of construction – what system was used to build the shower system. Most older custom tile showers are built using a copper pan to collect any water that breaks through the grout lines and floor seams.
Level of experience the contractor has. When building a custom tile shower, there may be several contractors involved. The General contractor, the plumber, and tile contractor. At some point one, they will probably miss an aspect of proper shower construction.
When a shower is showing signs of leaks, it is better to consult with an experienced shower system contractor who can properly assess the situation and make proper recommendations for a repair or replacement.
We are hoping that these few tips will help you with your shower. But if you feel you can not tackle the project on your own, feel free to contact us in Massachusetts or Rhode Island.


3.3.2 Optimization Considerations When Mixing C/C++ and Assembly 59 3.5.1 Use Caution With asm Statements in Optimized Code . Unconstrained L-BFGS and CG optimizers. C++ Optimization Strategies and Techniques. Mark Lacey Microsoft Corporation. Discusses ways in which the Microsoft® Visual C++® compiler can optimize source code for speed and size and tells why code size matters. Get a handle on optimizing floating-point code using the Microsoft Visual C++ ( version 8.0) method of managing floating-point semantics. I'm working on scientific code that is very performance-critical. Instantly access Optimized C++ by Kurt Guntheroth. Languages supported: C++, C#, VBA, Pascal. The C++ Standard Template Library (STL) provides the template function sort that implements a comparison sort algorithm. /O2 optimizes code for maximum speed. Start your free 10-day trial of Safari. This is an approximate transcript of my talk at Facebook NYC on December 4, 2012, which discusses optimization tips for C++ programs. / Od disables optimization, speeding compilation and simplifying debugging. /Ob controls inline function expansion. Three Optimization Tips for C++ Andrei Alexandrescu, Ph.D.


text:
Tag: wisconsin news
Wisconsin's top cop: 'It's about protecting the citizens'
ByadminOctober 8, 2021
The top Wisconsin cop, Aaron Miller, said Sunday that he would not resign, but said that he wanted to make clear that he had not resigned because he was under investigation by the Milwaukee Police Department."I've been the Milwaukee police chief for 11 years, and
Wisconsin, Wisconsin, and Wisconsin News and Politics
WISCONSIN — The state Senate on Tuesday narrowly approved a bill that would repeal the so-called death penalty and allow inmates to choose between death or life in prison without parole.Senate Bill 541 would also restore public safety by requiring all Wisconsin inmates to
'We are a nation of heroes': Jill Biden's wife on the eve of election, says Jill Biden
WASHINGTON – President-elect Jill Biden said Saturday that the nation of America was "on the brink of a historic moment" and that Americans should vote for someone "who will stand with us."Biden made the remarks as she campaigned for a


LT NOW. 4 - LiveTrends Design | Living. Design.
When space is at a premium, even the "essential" pieces tend to serve multiple purposes. Design-forward desks double as dressing tables. Sleek materials and surprising shapes transform storage containers into conversation pieces. By uniting form and function in such perfect harmony, this trend does more than make life easier—it reminds us that life is simply better when our needs and wants are the same.
Featuring living tillandsia resting on bright green moss dotted with colorful wildflowers, this dual-purpose statement piece adds a little spring to your story collection.
The materials we use make a statement—not just about personal style, but also about our relationship with the world. For instance, we no longer use types of wood for just for their beauty. We must also consider sustainability.
Hemp and flax are again rising as design's favorite fibers. They're kinder to the earth than cotton, and just as cozy to cuddle up with. The savviest brands will use this trend to spark real transformation. After all, caring about where you come from never goes out of style.
Living tillandsia entwined with a sprig of dried flowers and topped with Earth-friendly cork. Our Ikebana collection—inspired by the Japanese art of flower arranging—is a living meditation on our connection with nature.
Our place doesn't have to be a palace, but it must reflect our personal palette. The aim is to turn our homes (tiny or otherwise) into a haven of self-expression—a place where artistry is celebrated and inspiration is unleashed in new and unusual ways. Our new showpieces are "perfectly" imperfect, with irregular contours and brush strokes that echo the crafter's hand. Abstract patterns evoke the bold color and striking splashes of a master expressionist.
The way we decorate our homes is constantly evolving—not only what we surround ourselves with, but how we display it. Those with the skill, time, and eye to create their unique DIY masterpiece now have untraditional, new materials to display it with. Would we love a few trompe l'oeil frames crafted from versatile washi tape on our walls?
For a hiking trip to Zion National Park in Utah, we lucked out and found the perfect jacket. Both practical and chic, with a stitched pocket so your precious essentials can follow you anywhere. Just like this charming air plant.
One driving force behind our pared-down interiors is the desire to spend more time outdoors. We want to immerse ourselves in Earth's natural wonders and reconnect—however briefly—to our primal roots. While we can't go off the grid for too long, we can bring a touch of the outdoors in. Watch for a proliferation of fabrics, patterns, and textures inspired by underwater structures, geological formations, microorganisms, and even mushrooms! Consider it a tribute to Mother Nature, the world's first great designer.
Inspired by the furniture designs of Danish master Kaare Klint, this piece features a live bonsai encased in geometric shapes and natural woven cane. A beautiful way to bring a touch of nature to any space.
and the deeper, richer, and bolder, the better. We're ditching dusty old design rules. Letting our patterns play, our colors clash, and our textures mismatch. The results are gorgeously unpredictable, proving that small spaces can still pack big personality.
We'll never forget the first time we looked into a kaleidoscope. Such brilliant disruption of ordinary vision. Such a captivating collision of shapes and color moving in endless combinations. It seemed like magic. Still does.


IS A SAFARI GOOD VACATION FOR KIDS?
You have been planning for a safari for years but now you have a family and wondering if it's a good idea to take your kids on the African adventure. Family vacations mean no person left behind. However, multi-generational trips can be very tricky. So, should you take your kids on that safari? Our answer, YES!
However, we discourage taking infants and toddlers on safaris because of the long flights, adjusting to time difference and early mornings. Children from the age of six are can better experience the wilderness and engage with the tour guides. Safaris for kids can have a lasting impression and encourage them to explore the world when they are older. A family safari is a unique experience for the whole family.
Not all camps accept kids so check with specific camps to see what their policy is on kids. Younger children can participate in various lodge activities, horseback riding, Big Five sighting and appreciation of local cultures. The whole trip is transformative for children and young adults because they understand the need for conservation.
In Kenya the kids will visit authentic Masai villages, meet the Maasai people who dress in their traditional Shuka's (robes) and beads from head to toe. The Masai Mara among other game reserves are a great place for game drives with the children. There are big cat sightings on guided safaris and the kids will be excited to search and actually view these animals.
Additionally, you can combine a safari with the beach because you can easily go from one place to the other. Combining activities ensures maximum enjoyment for all the family members.
If you are travelling with kids make sure to prepare them psychologically (and yourself too) and keep them engaged throughout the trip to avoid cries of "I'm bored".
A family trip with kids helps them create special memories that might get them excited about the next family vacation.
You can check out more tips on travelling with children on safari on our website.


Do you know the difference between sunnis and shiites? Do you realize that Iraq is a secular state, even though most of her people follow Islam? Do you know that Saddam hated Al-qaeda and would have been our ally in capturing him? Or are you saying that we were right to attack?


text:
Jaskinia za Ratuszem Szeroka – jaskinia w Dolinie Miętusiej w Tatrach Zachodnich. Wejście do niej znajduje się w Litworowym Grzbiecie, w pobliżu Jaskini za Ratuszem Owalnej, na wysokości 1649 m n.p.m. Długość jaskini wynosi 13 metrów, a jej deniwelacja 5,5 metra.

Opis jaskini
Główną częścią jaskini jest sala, do której wchodzi się z obszernego otworu wejściowego. Odchodzą z niej dwa krótkie korytarzyki oraz 5-metrowa szczelina z zaklinowanymi głazami.

Przyroda
W jaskini brak jest nacieków. Ściany są mokre. Roślinność występuje tylko w sali.

Historia odkryć
Jaskinia była prawdopodobnie znana od dawna. Jej opis i plan sporządziła I. Luty przy pomocy M. Tomaszka w sierpniu 1994 roku.

Przypisy

Jaskinie polskich Tatr
Jaskinie Tatr Zachodnich

redpajama_set_name: RedPajamaWikipedia


text:
Reading the Zodiac: Swoonworthy Books for Every Sign (Part I)
Val O. • For Fun
Sometimes the TBR piles so high, you need a bit of guidance from above. Below are our bookish picks for the first six astrological signs!
(March 21-April 19)
Should she follow orders... or her heart?
Paige knows exactly what she wants—to graduate from Wallingford Academy and become a pilot in the US Air Force. She's inherited her father's no-nonsense attitude and whip-smart intelligence, both of which have made her the perfect Wallingford cadet.
Wallingford Academy is the last place in the world Logan wants to be. But after his girlfriend borrows his car and commits a crime, Logan takes the fall and ends up there with hopes of striking a decent plea bargain. For him, graduation can't come soon enough.
When Paige is asked to mentor Logan, it's the perfect opportunity to prove her leadership skills—but she doesn't account for the feelings that start to develop or the baggage from Logan's past which could threaten both of their futures.
(April 20-May 20)
Can Winnie balance the title of Summer Queen with her friendships and a new romance?
Winnie is living her best fat girl life and is on her way to her favorite place – Misty Haven and her granny's diner, Goldeen's. With her family and ungirlfriend at her side, she has everything she needs for one last perfect summer before starting college in the fall.
…until she becomes Misty Haven's Summer Queen.
Newly crowned, Winnie is forced to take center stage at a never-ending list of community royal engagements. Almost immediately, she discovers that she's deathly afraid of it all: the spotlight, the obligations, and the way her Summer King wears his heart, humor, and honesty on his sleeve.
To salvage her summer Winnie must conquer her fears, defy expectations, and be the best Winnie she knows she can be—regardless of what anyone else thinks of her.
(May 21-June 20)
What happens when you fall in love with your worst enemy?
Paisley and Carter are on the fast-track to becoming a couple. The two met at a party first week of freshman year and immediately hit it off. But things take a left-turn when Paisley finds out she's crossed paths with Carter before: He used to viciously bully her best friend, Henry, in middle school. Love story OVER. But fate has other plans…
Can Paisley enact revenge on Carter on her friend's behalf? Can Carter convince Paisley he's not really that bad of a guy?
In The Shortest Distance Between Love & Hate, Sandy Hall has created a delightful battle of wills between two teenagers who discover that there's a thin line between two of our most powerful emotions.
(June 21-July 22)
How brave can you be when your relationship is questioned by everyone you love?
The last thing Elise wants is to start her senior year in a new town. But after her brother's death in Afghanistan, she and her mother move from San Francisco to a sleepy coastal village.
When Elise meets Mati, they quickly discover how much they have in common. Mati is new to town too, visiting the U.S. with his family. Over the course of the summer, their relationship begins to blossom, and what starts out as a friendship becomes so much more.
But as Elise and Mati grow closer, her family becomes more and more uncomfortable with their relationship, and their concerns all center on one fact—Mati is Afghan.
Beautifully written, utterly compelling, and ultimately hopeful, The Impossibility of Us asks—how brave can you be when your relationship is questioned by everyone you love?
(July 23-August 22)
Sometimes you've got to live outside the lines.
Seventeen-year-old Bex is thrilled when she gets an internship on her favorite tv show, Silver Falls. Unfortunately, the internship isn't quite what she expected... instead of sitting in a crowded writer's room volleying ideas back and forth, Production Interns are stuck picking up the coffee.
Determined to prove her worth as a writer, Bex drafts her own script and shares it with the head writer—who promptly reworks it and passes it off as his own! Bex is understandably furious, yet... maybe this is just how the industry works? But when they rewrite her proudly lesbian character as straight, that's the last straw! It's time for Bex and her crush to fight back.
Jen Wilde's newest novel is both a fun, diverse love story and a very relevant, modern take on the portrayal of LGBT characters in media.
(August 23-September 22)
Rule #1: Don't get attached.
Amber lives by strict rules to survive her mother's love life: Always keep your eyes on the horizon and never get close to anyone connected to Mom's boyfriends.
But after they move in with Kevin, the latest of her mom's "soulmates," the rules become increasingly difficult to follow. Kevin's daughter, Cammie, keeps acting like Amber's friend, even though she's definitely not. And Jordan—star basketball player, hottest boy in school, and Cammie's best friend—keeps showing up at the most inconvenient moments.
Amber has reasons for every one of her rules, and following them is the only way to protect her heart when her mom inevitably moves on. But as she spends more time with Kevin, his daughter, and especially Jordan, she starts to wonder if the rules might be worth breaking this time.
Tags: Going Off Script, reading, The Shortest Distance Between Love and Hate, Risking It All, Rules We're Meant to Break, Val O., If It Makes You Happy, book recommendations, The Impossibility of Us
Val O.
Ask me about Pennsylvania.
Swoonscopes: Unleash Your Inner Aquarius and Fight the Power
ICYMI: Your Guide to Read Month on Swoon Reads
A Launch Party (or Two) to Remember
Reminder: The Season 19 Submission Deadline Is TONIGHT!


Christ behind me and before me.
Christ to comfort and restore.
Christ in hearts of all who know me.
Christ in quiet and in roar.
Wisdom teach me, watching o'er me.
Love to conquer every fear.
Emma Townend, Joseph Townend and Stuart Townend Copyright © 2018 Townend Songs (Adm. by Song Solutions www.songsolutions.org). All rights reserved. Used by permission.


text:
The "Miracle" Nasdaq 100
For anyone unfamiliar with the 1969 Miracle Mets, the "Amazins" were 10 games out of first place as late as mid-August and then went on to win 38 out of their last 49 games to finish in first place over the Cubs. From there, the Mets went on to win the first World Series in the history of the franchise in what at the time was one of the biggest turnarounds in the history of baseball. Ironically, in 2007, the Mets were on the other end of another historic turnaround after they blew a seven-game division lead with less than a month left in the season by losing 12 of their last 17 games. But that collapse is a story for another time.
Like the Miracle Mets in 1969, the Nasdaq 100 in 2020 has also staged a historic turnaround. After trading up over 10% earlier in the year, the gains quickly evaporated with the COVID outbreak. Within two months, the Nasdaq 100 went from a YTD gain of over 10% to a decline of over 20% by late March. From there, though, the Nasdaq has gone on an epic run, not only erasing all of its losses but also trading to record highs and a gain of over 20% on the year.
The frequency of positive days for the Nasdaq 100 provides another illustration of the index's strength this year. So far this year, the index has traded higher on 63% of all trading days. That may not sound like much, but if the year were to end today, it would be the highest percentage of positive days for a given year in the Nasdaq 100's history. On a side note, it's interesting to see in this chart how similar the percentage of positive days has been on a year to year basis over time. There has never been a year where fewer than 46% of all trading days have been positive, and prior to 2020, there has never been a year where more than 62% of all trading days were higher.
Obviously, the year is only a bit more than half over, so it's far from a guarantee that the percentage of positive days will remain as elevated as it is now. To make an apples to apples comparison, in our most recent B.I.G. Tips report we looked at prior years where the Nasdaq 100 saw a similar consistency of daily gains to see how the rest of the year played out. To read the entire report login or start a two-week free trial to either Bespoke Premium or Bespoke Institutional.


New I cleaned the inside of my scanner glass!
New USB Microscope: Any recommendations?
New WARNING: Photobucket users please read this.
New Anyone having problems with IMGUR?
New Digital Stamp Image husbandry.
Questions or recommendations regarding computers, operating systems, software, or peripheral devices. Post questions about Forum software on the FORUM HELP DESK board.


This 1985 Mercedes-Benz 300D Turbodiesel sedan is finished in Petrol Blue Green Metallic over Creme Beige MB-Tex and was registered in Texas from new until its recent acquisition by the selling dealer. Power comes from a 3.0-liter OM617 turbodiesel inline-five paired with a 4-speed automatic transmission, and recent maintenance included an air conditioning service, fuel line replacements, oil change, and general inspection. This diesel W123 is offered at no reserve with a clean Carfax report and a clean Pennsylvania title.
The exterior is finished in Petrol Blue Green Metallic (877) accented with chrome US-spec bumpers and polished window surrounds. Paintwork is noted to have been performed along a passenger-side door and quarter panel. The Carfax report shows no accidents or other damage.
Factory 14" Bundt wheels are equipped with Mercedes center caps and wear Michelin Defender tires displaying 2017 date codes. The brakes were reportedly serviced and new upper control arms were installed in 2017.
The cabin is trimmed in Creme Beige MB-Tex upholstery (155) accented with woodgrain trim and Coco mats. Materials and finishes are detailed up close in the gallery below along with instrumentation, controls, and power accessories. The 6-digit odometer reads just over 268k miles.
The 3.0-liter OM617 turbodiesel inline-five was factory rated at 125 horsepower and is linked to the rear wheels through a 4-speed automatic transmission. Recent maintenance is said to have included an A/C service, fuel line and belt replacements, oil change, and general inspection, with results from the latter provided below.
Numerous photos of the underside are included in the gallery.
Videos highlighting the exterior and interior are viewable above.
The Carfax report shows no history of accidents and confirms longterm Texas history from 1985-2018.