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Assay Central
Collaborating with us
Sean Ekins
Correspondence published in Nature Biotechnology
Today, we had a correspondence published in Nature Biotechnology about "Industrializing rare disease therapy discovery and development". We hope this will spark discussion on how such treatments can be developed cost effectively and how in the future we can attempt to bring the costs for rare disease treatment development even lower so that many more diseases can be addressed.
Collaborations Pharmaceuticals, Inc. Announce NIH Award to Develop New Software for Drug Discovery
Fuquay Varina – The National Institute of General Medical Sciences (NIGMS) recently awarded $149,999 to Collaborations Pharmaceuticals, Inc. (CPI) to develop software that could make public data more amenable to those scientists who want to use it to build computational models to help their research.
There are massive publically accessible databases that include a broad variety of disease targets and absorption, distribution, metabolism, excretion and toxicology (ADMET) properties that are not in a form that is immediately ready for machine learning model building or accessible for use by small research and development (R&D) organizations that do not have their own in-house cheminformatics teams. This project will compile a comprehensive collection of these datasets (e.g. databases like PubChem, ChEMBL etc) for structure-activity data. This will enable the user to quickly and automatically use machine learning models for various targets and properties that could be of value for drug discovery.
"Being able to use transparent computational models simultaneously for visualizing activity trends for multiple targets (both diseases and ADMET) removes the burden of curation or purchasing and maintaining expensive software, and drastically simplifies the addition of new data. It also represents a new frontier of drug discovery as a world of small, agile distributed R&D organizations has access to valuable public datasets that can inform their research. Such computational models will assist in drug repurposing efforts internally and with our collaborators while likely identifying new compounds for a wide array of drug discovery projects" said Sean Ekins, CEO CPI.
"We are very grateful to NIGMS for funding so we can illustrate how computational approaches can be used to repurpose drugs already approved for other uses and instead use for neglected and rare diseases" said Dr. Ekins.
About Collaborations Pharmaceuticals, Inc.
Collaborations Pharmaceuticals, Inc. performs research and development on innovative therapeutics for multiple rare and infectious diseases. We partner with leading academics, companies and foundations to identify and translate early preclinical to clinical stage assets. We have considerable experience in preclinical and computational approaches to drug discovery and toxicity prediction. For more information, please visit http://www.collaborationspharma.com/
Sean Ekins, Ph.D., D.Sc.
Collaborations Pharmaceuticals, Inc.
320 N Judd Parkway NE, Suite 217,
collaborationspharma@gmail.com
10th Nov 2016- Antimalarial being tested as possible Ebola virus drug
CPI and Texas Biomed announce NIH award to develop a treatment for Ebola
Fuquay Varina, N.C. (November 10, 2016) - The National Center for Advancing Translational Sciences (NCATS) recently awarded $596,533.00 to Collaborations Pharmaceuticals, Inc. (CPI) to initiate a partnership with Texas Biomedical Research Institute aimed at repurposing an antimalarial for use against the Ebola virus.
Since 2014, the outbreak of the Ebola virus in West Africa has resulted in 28,657 suspected cases and 11,325 deaths (according to WHO statistics) and highlighted the need for broad-spectrum antiviral drugs for this and other emerging viruses. Data from a published large scale high throughput screen performed by SRI International and Texas Biomedical Research Institute was used to create machine learning models that identified 3 compounds active against the virus in vitro (in a lab, outside of a living organism). This earlier work had suggested that antimalarial compounds, as well as other classes of approved drugs could be of interest for repurposing.
"We used Bayesian machine learning models based on the earlier published dataset to screen a library of more than 2000 drugs and drug-like molecules, which then lead to the discovery that of the 3 compounds identified, a relatively new antimalarial called pyronaridine, approved in Europe had promising activity in vitro and could be worthy of testing in vivo (in a living organism) against the Ebola virus" said Sean Ekins, CEO CPI.
"My lab has screened thousands of compounds against Ebola virus," said Dr. Robert Davey, Interim Chair of Texas Biomed's Department of Virology and Immunology. "This particular compound, pyronaridine, is promising because it is already an approved drug in Europe, has been used in thousands of patients and may have favorable molecular properties that could speed up its transition to clinical testing. We do not currently know the target of the three compounds and there is still considerable research needed."
Dr. Davey is interested in understanding how viruses like Ebola virus penetrate the cell membrane and establish infection. In addition, Dr. Davey's laboratory has developed safe, efficient, high-throughput screening techniques for Ebola virus and performs contract work on testing drugs and compounds against Ebola virus infection in the biosafety level-4 maximum containment laboratory. This work has resulted in exciting findings towards potential drug candidates to combat Ebola virus.
"This collaboration involves Texas Biomedical Research Institute, Stanford Research International and Rutgers University, and we are very grateful to NCATS for funding so we can illustrate how computational approaches can be used to repurpose drugs already approved for other uses and instead use for neglected diseases" said Dr. Ekins.
About Texas Biomedical Research Institute
Texas Biomed is one of the world's leading independent biomedical research institutions dedicated to advancing health worldwide through innovative biomedical research. Texas Biomed partners with hundreds of researchers and institutions around the world to develop vaccines and therapeutics against viral pathogens causing AIDS, hepatitis, herpes, hemorrhagic fevers and parasitic diseases responsible for malaria and schistosomiasis. The Institute also has programs in the genetics of cardiovascular disease, diabetes, obesity, psychiatric disorders and other diseases. Texas Biomed is home to the Southwest National Primate Research Center, one of seven NIH-supported primate research centers in the United States. For more information on Texas Biomed, go to http://www.TxBiomed.org.
Collaborations Pharmaceuticals, Inc. performs research and development on innovative therapeutics for multiple rare and infectious diseases. We partner with leading academics and companies to identify and translate early preclinical to clinical stage assets. We have considerable experience in preclinical and computational approaches to drug discovery and toxicity prediction. For more information, please visit http://www.collaborationspharma.com/
8th Nov 2016- One NC small business program: Award of matching grant
Collaborations Pharmaceuticals, Inc. has been selected for a Stage 1 Grant Award of $32,346.50 under the One North Carolina SBIR/STTR Matching Funds Program Solicitation, Funding Opportunity Number NCBST-FY16-17M, closing on June 30, 2017 (the "Solicitation"). The Phase I Matching Funds Program is designed to award matching funds to North Carolina businesses who have been awarded a SBIR or STTR Phase I award.
This funding will be important as the company grows, hires staff and supports local businesses. We are very grateful for the support of the North Carolina Office of Science, Technology & Innovation.
16 -Aug 2016 - Collaborations Pharmaceuticals, Inc. and Rutgers announce NIH Award to develop treatments for tuberculosis
Fuquay-Varina, North Carolina – The National Institute of Allergy and Infectious Diseases (NIAID) recently awarded $149,388 to Collaborations Pharma, Inc. (CPI) to initiate a partnership with Rutgers aimed at developing a series of compounds for treating tuberculosis (TB), an infectious disease generally affecting the lungs in humans and caused by the bacterium Mycobacterium tuberculosis (Mtb).
One-third of the global population is understood to be infected with TB and the disease continues to kill 1.5 million people every year and to infect approximately 9 million. Despite the availability of effective treatments for the disease, the combined impacts of drug resistance and morbidity of patients co-infected with HIV/AIDS have stimulated research on new quicker acting (less than the current six-month minimum) treatments efficacious against drug-resistant infections that are less toxic when used with anti-retroviral regimens for HIV/AIDS.
"We initially used Bayesian machine learning models to rediscover a class of compounds which seems to have been neglected for over 40 years ago. The compound we found has activity against drug-sensitive TB as well drug-resistant forms" said Sean Ekins, CEO CPI.
"To date my lab has made many analogs of the initial active compound we co-discovered with Dr. Ekins. Our plan is to focus on addressing limitations using computational models developed by CPI to see if we can arrive at a compound with good activity in an acute mouse model of the disease" said Dr. Joel S. Freundlich, Associate Professor of Pharmacology, Physiology & Neuroscience and Medicine at Rutgers University–New Jersey Medical School.
Dr. Freundlich has a chemical biology lab of eleven scientists that utilizes a multi-disciplinary approach to study infectious diseases, with a specific focus on tuberculosis. His lab will aim to identify potential drug candidates as well as the mechanism of action of this antitubercular class. Ultimately their goal is to optimize this compound class to develop a commercially viable new series of antibacterials.
"This work is a wonderful example of our efforts to involve outside companies in our search for novel antibacterials" said Dr. David Perlin, Executive Director, Professor at the Public Health Research Institute Center at Rutgers and Principal Investigator, NIH/NIAID Center of Excellence in Translational Research.
"We are very grateful to NIAID for funding this project as CPI is focused on collaborations with academia so that we can apply our computational approaches to real world applications that can impact research on neglected diseases" said Dr. Ekins.
About Rutgers New Jersey Medical School
Founded in 1954, Rutgers New Jersey Medical School is the oldest school of medicine in the state. Today it is part of Rutgers, The State University of New Jersey, and graduates approximately 170 physicians a year. Dedicated to excellence in education, research, clinical care and community outreach, the medical school comprises 22 academic departments and works with several healthcare partners, including its principal teaching hospital, Newark University Hospital. Its faculty consists of numerous world-renowned scientists and many of the region's "top doctors." New Jersey Medical School hosts more than 50 centers and institutes, including the Public Health Research Institute Center, the Global Tuberculosis Institute and the Neurological Institute of New Jersey. For more information please visit: njms.rutgers.edu
Collaborations Pharmaceuticals, Inc. performs research and development on innovative therapeutics for multiple rare and infectious diseases. We partner with academics or companies to identify and translate early preclinical to clinical stage assets. We have considerable experience of preclinical and computational approaches to drug discovery and toxicity prediction. For more information, please visit http://www.collaborationspharma.com/
5616 Hilltop Needmore Road,
Collaborations Pharmaceuticals participates in OpenZika launch
Zika Treatment Search Launched, Fueled By IBM's World Community Grid Crowdsourced research project aimed at helping scientists cure debilitating disease
ARMONK, NY – 19 May 2016: IBM's (NYSE: IBM) World Community Grid and scientists are launching an international study to identify drug candidates to cure Zika, a fast spreading virus that the World Health Organization has declared a global public health emergency.
IBM and a global team of scientists are inviting anyone with a computer or Android device to join the #OpenZika project. Volunteers don't need to provide time, expertise or money to help; they simply run an app on their Windows, Mac, Linux or Android devices that automatically performs virtual experiments for scientists whenever the machines are otherwise idle.
Through the OpenZika project, World Community Grid will power virtual experiments on compounds that could form the basis of antiviral drugs to cure the Zika virus, which has been linked to serious neurological disorders. With dramatically more speed than possible in a traditional lab, the project will screen compounds from existing molecule databases against models of Zika protein and crystal structures. Screening results will quickly be shared with the research community and general public. Promising compounds would then be tested in the collaborators' laboratories.
For the OpenZika project, World Community Grid is working with an international team of researchers led in Brazil by the Federal University of Goias, and with support from Brazil's Oswaldo Cruz Foundation (Fiocruz); Rutgers University's New Jersey Medical School; Collaborations Pharmaceuticals, Inc.; and the Skaggs School of Pharmacy and Pharmaceutical Sciences at the University of California San Diego.
"Enlisting the help of World Community Grid volunteers will enable us to computationally evaluate over 20 million compounds in just the initial phase and potentially up to 90 million compounds in future phases," said Carolina H. Andrade, Ph.D., professor at the Federal University of Goiás in Brazil and the lead researcher on the OpenZika project. "Running the OpenZika project on World Community Grid will allow us to greatly expand the scale of our project, and it will accelerate the rate at which we can obtain the results toward an antiviral drug for the Zika virus."
The need for a treatment is acute as warmer weather approaches North America, creating an environment more conducive to Zika-carrying mosquitoes, and as international travelers contract and transmit the virus.
Other anti viral research efforts also hold promise. For example, IBM Research and Singapore's Institute of Bioengineering and Nanotechnology announced that they have identified a macromolecule that could help prevent deadly viral infections such as Zika. IBM has provided its expertise and resources for other disease outbreaks, such as Ebola. For instance, IBM's World Community Grid launched a project on Ebola research.
In addition, IBM has helped governments track diseases outbreaks.The company provided a citizen engagement and analytics system in Sierra Leone that enables communities affected by Ebola to communicate their issues and concerns directly to the government. For that pubic health emergency, IBM Research also created opinion-based heat-maps which correlated public sentiment to reported outbreak locations. IBM scientists have created a free, open source tool that helps scientists and public health officials create, use and study spatial and temporal models of emerging infectious diseases such as Zika.
As part of its citizenship program focused on innovative solutions to societal problems, IBM created World Community Grid in 2004 to address researchers' critical need for supercomputing power. Partially hosted on IBM's SoftLayer cloud technology, World Community Grid provides massive amounts of supercomputing power to scientists, free of charge. It does this by harnessing the unused computing power of volunteers' computers and Android devices. More than three million computers and mobile devices used by nearly three quarters of one million people and 470 institutions across 80 countries have contributed virtual supercomputing power for more than two-dozen vitally important projects on World Community Grid over the last 11 years, at a value of more than $500 million.
World Community Grid has helped researchers identify new potential treatments for childhood cancer, identifying new materials for more efficient solar cells, and helping to identify how nanotechnology can filter water more efficiently. Many of these efforts might not have even been attempted without the free supercomputing power provided by IBM's World Community Grid.
To perform such computational experiments, OpenZika researchers are using a widely used virtual screening tool called AutoDock VINA, developed by the Olson laboratory at The Scripps Research Institute. At its core, World Community Grid is enabled by Berkeley Open Infrastructure for Network Computing (BOINC), an open source platform developed at the University of California, Berkeley and with support from the National Science Foundation.
Volunteers can support the OpenZika search for a cure by joining World Community Grid. IBM also invites researchers to submit research project proposals to receive this free resource. For more information about IBM's philanthropic efforts, please visit www.citizenIBM.com or follow @CitizenIBM on Twitter.
Contact(s) information
Ari Fishkind
IBM Media Relations
fishkind@us.ibm.com
Angie Hu
ahu@us.ibm.com
Incentives starting small companies focused on rare and neglected diseases
For a short time the recent paper on starting small companies is available for free.
First steps of a start-up rare disease company
A follow-up blog at Rare Disease Report
Advice for starting a rare disease company
Sean describes advice for starting a rare disease company at Rare Disease Reports
840 Main Campus Drive, Lab 3510


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By C.J. Wills, Introduced by Abbas Amanat In Biography & Memoir and History Tagged In 19th Century, Books by Abbas Amanat, Qajar, and Travel.
In the Land of the Lion & Sun: Experiences of Life in Persia from 1866-1881
Published Date: April 1, 2014
Clothbound Hardcover
Dimensions 5.5 x 8.5
C.J. Wills was an English physician who traveled widely in Iran from 186681-while working for the Indo-European Telegraph Department. With a discerning eye for detail, Wills wrote an intimate anthropological account of Qajar-era Iran, rich with description of everyday life, popular beliefs and practices, and arts and crafts, as well as health practices and communications that were his professional concern.
In the Land of the Lion and Sun, the second volume to appear in Mage's Persia Observed series, provides a fresh and fascinating insight into both a time and place, as well as the biases and sympathies of a generation.
In his introduction to this new edition of Wills' book, Abbas Amanat presents a critical reading of Wills' career, his works, and his view of Qajar Iran
"The character of the Persian, as it appears to me, is that of an easy-going man with a wish to make things pleasant generally. He is hospitable and obliging, as honest as the general run of mankind, and is specially well disposed to the foreigner. He is very kind and indulgent to his children, and as a son his respect for both parents is excessive, developed in a greater degree to his father, in whose presence he will rarely sit, and whom he is in the habit of addressing and speaking of as "master;" the full stream of his love and reverence is reserved for his mother and an undutiful son or daughter is hardly known in the country. Home virtues among the Persians are many.
No act of serious import is ever undertaken without the advice of the mother; no man would think, for instance, of marrying contrary to his mother's advice; and by the very poorest the support of their parents would never be looked on as as burden. Respect for the aged is universal; "this grey beard" is a common term of respect and an aged man or woman will frequently give an opinion unsolicited, and such advice is often requested, and always listed to as valuable." (p. 314)
"A visit to the tomb of Saadi, or that of Hafiz, is common among the Shirazis for the taking of omens or "fal," as they are termed. For a few coppers the dervish who usually acts as guardian to the tomb produces his well-thumbed manuscript copy of the poet, and, after an invocation to the Deity, he thrusts his knife into the closed volume between the leaves. Taking the passage at the top of the right-hand page, he recites it to the anxious inquirers" (p. 277)
C.J. Wills was an English physician who traveled widely in Iran from 1866-81 while working for the Indo-European Telegraph Department.
ABBAS AMANAT received his B.A. from Tehran University in 1971 and D.Phil. from Oxford University in 1981. His principal publications include Pivot of the Universe: Nasir al-Din Shah and the Iranian Monarchy, 1831-1896 (1997) and Resurrection and Renewal: the Making of the Babi Movement in Iran, 1844-1850 (1989). He is the editor of Cities and Trade: Consul Abbott on the Economy and Society of Iran (1983), Crowning Anguish: Memoirs of a Persian Princess from the Harem to Modernity (1995) and co editor of Imagining the End: Visions of Apocalypse from Ancient Middle East to Modern America (2002). He also edited The United States and the Middle East: Diplomatic and Economic Relations in Historical Perspective (2000) and co-edited The United States and the Middle East: Cultural Encounters (2002) and Apocalypse and Violence (2004). He is the editor of Mage's Persia Observed Series, which includes Edward Browne's The Persian Revolution of 1905-1909.
Abbas Amanat is a professor of history at Yale University.
← My Uncle Napoleon: A Comic Novel (Kindle/iPad Version) Letters From Tabriz: The Russian Suppression of the Iranian Constitutional Movement →
Persian Pleasures: How Iranian Relaxed Through the Centuries with Food, Drink and Drugs
By Willem Floor & Hasan Javadi $0
Karmanshah: City and Province, 1800-1945
By Willem Floor $0
Studies in the History of Medicine in Iran
Discovering Cyrus: The Persian Conqueror Astride the Ancient World
By Reza Zarghamee $0
Engelbert Kaempfer: Exotic Attractions in Persia, 1684–1688: Travels & Observations
By Engelbert Kaempfer, Translated & Annotated by Willem Floor & Colette Ouahes $0

redpajama_set_name: RedPajamaCommonCrawl


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Gavin Larsen in Fertile Ground Festival 2011
AuthorOBT BlogPosted on January 7, 2011 CategoriesBallet News, Gavin LarsenTagsFertile Ground Festival, Gavin Larsen
Fertile Ground 2011 is a ten-day arts festival celebrating new work by Portland artists. This year's festival will feature over 50 Portland-generated new works, along with a myriad of other arts events from Portland's creative community. From fully-staged world premieres in theatre, to ensemble and collaborative driven work, dance, comedy, visual art and film, this festival spans the spectrum of creative endeavor and seeds the next generation of creation through artist conversations, workshops, lunchtime readings and more.
Oregon Ballet Theatre staff and dancers will be participating in world premiere works all over town on seven of the ten days of the festival. Below is a choreographer interview with OBT's own Gavin Larsen about her work for the Fertile Ground Festival, from Fertile Ground's Blog written by OBT's own Claire Willett
NAME: Gavin Larsen
PROJECT: A Ghost In the Room With Us
A Ghost In the Room With Us plays at 7 pm on Wednesday, January 26th and 6pm on Sunday, January 30th at Conduit (918 SW Yamhill, 4th Floor). Tickets are $15. More info here.
ABOUT GAVIN
Gavin Larsen has danced with Pacific Northwest Ballet, Alberta Ballet, the Suzanne Farrell Ballet, Ballet Victoria and most recently as a principal dancer with Oregon Ballet Theatre. She is thrilled to continue exploring the limitless language of dance by incorporating, considering, and learning from the distinct dialects of her fellow artists and collaborators, David Biespiel and Joshua Pearl. Gavin is currently on the faculty of the School of Oregon Ballet Theatre.
EIGHT ONE-WORD ANSWERS
1. A Choreographer I Admire Is . . . I admire anyone with the bravery to create dance!
2. My Choreographic Style Can Be Described As . . . "Gavin Larsen the Dancer" Meets "Gavin Larsen speaking without words"
3. A Portland Artist I Admire Is . . . Josie Moseley
4. I Am Terrified Of . . . Feeling trapped
5. I Am Obsessed With . . . Moving and expanding outside the boundaries of my own skin
6. The Book Currently On My Nightstand Is . . . Blue Highways by William Least Heat Moon
7. Three Adjectives That Describe This Play Are . . . Thought-Provoking, Classic, Beautiful
8. In the Indie Art-House Biographical Film Of My Life, I Should Be Played By . . . [EDITOR'S NOTE: Gavin didn't answer this question, but Claire feels strongly that she should be played by Embeth Davidtz. If you've seen Matilda and have met Gavin, you will agree with her.]
FIVE QUESTIONS OF DEPTH AND SUBSTANCE
1. Tell us about your Fertile Ground Festival project.
Three of us, poet David Biespiel, dancer Gavin Larsen, and musician Joshua Pearl — the trio that call themselves Incorporamento — are returning to the Fertile Ground Festival with a collaboration of original poetry, dance, and music, "A Ghost in the Room with Us." Building on last year's heralded Fertile Ground performance, we're trying to allow audiences to interpret performance in a new way. We're defining and fusing the lines between three classic forms of art. "A Ghost in the Room with Us" burns with recollection, introspection, and meditative reverie in a fabulous performance of renewal, insight, and pleasure.
2. How did this piece come about? What inspired it?
As soon as last year's FG Festival shows ended, we were already talking about what we would do next. We knew we wanted to move to a more polished and fully produced show, much more in-depth, and include both original and existing work. We kept meeting to have "jam sessions" all spring and summer, and the pieces in this show are the results. We're inspired by the concept of noticing that inner self that we all have, who travels with us through life, but is often as mysterious and effervescent as a ghost.
3. Talk about your creative process. (How do you work? When do you work? What gets you moving?)
We each work independently, and then bring something to the table, so to speak, at each rehearsal. Some of our pieces were born from the seed of a piece of music, some from one of David's poems, and some from my movement. We blend them together without stepping all over each other's work.
4. What is the most exciting/inspiring piece of live performance you've seen in Portland?
Honestly, it's some of the OBT performances that I have either performed in or seen my colleagues do. I am routinely floored by the amount of talent and creativity in these studios.
5. What are you up to these days when you're not creating?
I teach full-time at the School of OBT and coach the children that appear in any OBT production, so that has kept me very busy all fall and winter. When I'm not doing that, I'm refreshing my soul by moving my body and trying to live up to the high creative standards of Joshua and David. Doing this FG performance is like getting a drink of water after a long thirsty spell. I can't stop gulping it down!
We are so proud to have so many OBT artists presenting work for the Fertile Ground Festival. Get your tickets or festival passes today!
Tell us what you think – What's the best part of seeing a world premiere performance?
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I hate it. Every day she comes with more scars. It's killing her. She's killing herself. But even more than that, it kills me to see her do it to herself. Even if i say that everything is going to be all right, she still goes, and she'll do it again.
And his drunken hands, the same hands that have touched bottle after bottle, smoke after smoke, are shaking with anger when she arrives.
And those hands, furious hands that have hurt her day after day, night in, night out, will do it again. Slap her, punch her, push her, shove her, kick her, smother. The hands that leave scars everywhere, all over her. But you wouldn't know it. She hides them. Long sleeved shorts, no matter the temperature. But believe you me, they're there. They loom in the shadows, the crevices, the creases, of her skin.
They spot a purple and blue hue at her neck, and dot a deep blue across her shoulders. They spiral with cuts and scrapes a repulsing red all down her rib cage, into her stomach, where they become more sparse. Then cuts, now a dark brown, except the fresher ones, stripe her lower back. Then, the most heart wrenching of all, a scar that's around eighteen inches long, now a deep green, right across her shoulder blades where he striked her with a red-hot fireplace poker.
And she won't get help.
She lets him destroy her.
Leave your comments below, and rate. Tell me what you think, and if i should write another one. Click on my name to read a few other stories by me. My website & email address will be open for you all soon. Any constructive criticism welcome!!


Super simple to make, this healthy side dish packs a crunchy, flavorful punch. Try serving the roasted wedged alongside our Slow-Cooker Corned Beef.
I love cabbage, never had any I did not like but........... this is the best ever! The texture and crispiness is wonderful. I dont know if I can ever go back to other former favorites!
Great recipe and easy!!!! I'm not sure what Fennel seeds are, but we use salt, pepper, and garlic powder. 30 minutes and they're done to perfection. The olive oil brings out the nutty taste in them and even people who aren't fans of cabbage will eat this!!!!!
I first made this recipe as a side for St. Patrick's Day meal. Didn't think I would love it as much as I did! Delicious!!! Didn't have fennel or caraway seeds, decided to use ground corriander instead. Came out very flavorful! Also, because I was short on time, only roasted for 30 min. Came out perfect, not mushy. Great recipe!
This is now my favorite way to cook cabbage. Easy, fast, and delicious. If you don't like the spices, try using different spices or just salt, pepper, and olive oil My family loves this recipe.
I made this for a family dinner. Everyone loved it, even family that does not like cabbage. I used fennel seeds and then sprinkled with fennel fronds when serving. Yum.
Looks really pretty, can't wait to try it. Just wondering out loud.. how do I wash the cabbages?
Remove the outside leaves and trim the stalk first, then rinse thoroughly and wipe away anything that feels gritty or looks iffy -- remove a couple more leaves if necessary. The inside of the head is clean already so you really only need to get anything that might have clung to the outside of the head.
I enjoy finishing with a big splash of balsamic vinegar.
I'd add some fresh garlic as well!!!
Roasted cabbage has been our "go-to" veggie, this winter-we eat it daily. A CuisinArt Griddler cuts the cooking time down to 15 min. We be LOVIN' our Griddler, too. It saves energy, by not having to heat an entire oven for 40+min. We roast all of our veggies, on the Griddle, thus achieving the Maillard Reaction, meaning more flavorful food. Our Griddler is still running after 4+ yrs of almost daily use.
Sound hood. Do you close the griddle to cook it like a panini sandwich?
Very nice post in here . Great job Martha . .


10.5" Rear Red with BLACK Spring Mono Shock Dirt Pit Bike SDG SSR Taotao Coolster 110cc 125cc 290mm (12") total length 270mm (10.5") Length of eye to eye. Eye Diameter (Bushing): 10mm (0.4") Eye thickness : 2.00mm (0.8") Spring thickness: 11mm (0.43") Spring Width: 2.5" The eye of shock has tensile strength more than 2,000 Kgf Spring Weight: 980 lbs.
If you have any questions about this product by NEW ANIME, contact us by completing and submitting the form below. If you are looking for a specif part number, please include it with your message.


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Community April 13, 2020
The U's global relationships support COVID-19 response
The University of Utah's international connections are serving as a potent reminder of the benefits of collaboration across our global community during the COVID-19 pandemic.
Cecily Sakrison - Office for Global Engagement
The University of Utah's international connections are serving as a potent reminder of the benefits of collaboration across our global community as the deluge of dire news about COVID-19 floods newsfeeds and individuals feel increasingly isolated in its midst.
In September 2014, when the university opened its U Asia Campus (UAC) in Incheon, South Korea, administrators eagerly embraced the opportunity to create enriching cross-cultural experiences for faculty and students, expand recruitment and establish a presence in the Asia market. Nobody could have foreseen the role that the partnership would play in the midst of the current pandemic.
Through connections facilitated by the Office for Global Engagement and UAC, Dr. Michael Good, CEO of University of Utah Health and senior vice president of Health Sciences, has recently been able to exchange firsthand COVID-19 response strategies with Dr. Young Mo Kim, former UAC Advisory Board member and president and CEO of Inha University Medical Center.
"Through our campus in Korea, we learned that relationship building was a critical part of succeeding in Asia. Establishing those personal relationships has really paved the way for the type of direct communication that has developed between Drs. Good and Kim," said Dr. Chris Ireland, the U's chief global officer.
South Korea saw its first wave of coronavirus begin in mid-February. While U administrators were working quickly to ensure the safety of students and faculty at UAC—moving courses online and asking residents to limit movement and interaction—the same precautions would not happen for several weeks at the U's campus in Utah.
Pointing to a chart illustrating the curve of new cases in South Korea over the last month, Good praised the country's prevention efforts and remarked, "South Korea shows a nice example for us of exactly what we're trying to do. We're trying to get over the infection curve, get it as low as we can, keep it below the capabilities of our health system and try to get it to this new steady state where we can always take care of the patients who need our care."
The month difference has served as a preview of what's to come, and the communication between Kim and Good has enhanced University of Utah Health's ability to respond rather than react.
"We're really fortunate to be part of the University of Utah," continued Good, noting the U's Asia Campus. "Through colleagues, we've been able to establish really good conversations with leaders at Inha University hospital. We've had three conversations with them now about approaches that they've used in South Korea to achieve those really impressive results."
The collaboration has informed best practices in structuring patient flow through facilities and recommendations to keep providers healthy.
"We'll continue to speak with our colleagues in South Korea and learn from them and the experiences they've had in dealing with this pandemic," said Good.
Posted in Community, Faculty/Staff, Health & Medicine, StudentsTagged COVID-19 Response, Dr. Michael Good, Incheon, Shawn Wood, South Korea, U Asia Campus, University of Utah Health


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Posted on January 18, 2016 January 5, 2017 by Thomas Valentine
Trump's Fire and Brimstone Attack Rains Down on Cruz
Over the weekend, Donald Trump appeared on ABC's "This Week," where he was challenged by host George Stephanopoulos to respond to charges from rival Ted Cruz and others that he would not be a conservative president. You can watch the exchange and read the transcript below (starts at 2:36):
STEPHANOPOULOS: He's also circulating that clip of you on Tim Russert in 1999, where you said, "I lived in New York City, in Manhattan, all my life, OK? So, you know my views are a little bit different than if I lived in Iowa." So those were your words.
TRUMP: Yes, a long time ago. And, just so you understand, he's taking money from people that are very much into the whole gay marriage situation and he's taking money from them and he's, you know, raising funds from them. Then he got caught the other day on a tape when he was raising funds at a law office, talking about things that are priorities and not priorities. This was not a priority.
STEPHANOPOULOS: So you're saying he's a hypocrite?
TRUMP: Oh, he's a total hypocrite.
How about his fundraising and how about when he does his personal financial disclosure form and he doesn't put on that he's borrowing money from Goldman Sachs and then today it comes out that he's also borrowing money from Citibank and he doesn't list it. You know why? He wants to look like Robin Hood, that he is the one protecting the people from the banks. Well, he's actually borrowing money and personally guaranteeing it and not disclosing it, which is illegal.
STEPHANOPOULOS: But how about you? Those were your words. You were talking about, in that interview, issues like gay marriage, talking about how you were strongly pro-choice. And as your comparison of New York values and Iowa views. And it's led a lot of conservatives to think boy, maybe he's going to switch again. He's not going to be (INAUDIBLE)…
TRUMP: See, it doesn't matter what they think. It doesn't matter. They understand me. They understand trade. I don't consider myself to be anything, you know, when they ask labels. We're talking about labels. I consider myself to be, right now, somebody that…
STEPHANOPOULOS: So you're not a conservative?
TRUMP: No, I'm conservative, but when it comes to different elements of what I believe in, that's what people really understand. I'm going to solve our trade problem. I'm going to solve our military problem. I'm going to get rid of ISIS. I'm going to create borders. I'm going to do the things that this is what they want.
STEPHANOPOULOS: But they are — they're afraid you're going to abandon conservative issues if you get the nomination.
TRUMP: I don't think too many people are afraid of that, OK, because if you look at the polls, I'm leading Ted Cruz by a lot. He even lied about that. You know, he got up and said, well, the polls — well, the polls are showing that I'm the one that's on the up swing. He's the one on the down swing, a big down swing. But when you look at what he said and when you look at the way he said it and the scorn toward New York, I thought it was a disgrace, in light of the World Trade Center, in light of all the people that died. And think about the firemen — the firemen that went up those buildings and they were killed instantaneously. And they probably pretty much knew those buildings were coming down and they're going up to save lives. And, by the way, speaking of Iowa, which I love, and I'm leading in the polls right now in Iowa, by the way, but I love — we had firemen from Iowa which was so beautiful, and other places, many other places, coming to the World Trade Center to help. You had people from Iowa, and in particular, the fire department, coming all the way from Iowa to help with the World Trade Center. And here's Ted Cruz putting down that and the great, you know, the great…
STEPHANOPOULOS: Well, he didn't put that down.
TRUMP: — people of New York. No, he's putting down the great people of New York. Hey, you've been there. Who could have done — very few people could have done what New Yorkers did under that unbelievable circumstance.
STEPHANOPOULOS: Let's talk about some of the issues. Judges. What kind of judges will you appoint? Will they be conservative? What does that mean to you and how will you ensure it?
TRUMP: Well, first of all, we have a lot of judges that have to be appointed because we have a lot of openings in terms of judges. And I'm very happy about that, to be honest, because I think, you know, appointing judges is a very important and a very, frankly, a very, very important element of what we're doing.
STEPHANOPOULOS: But Ted Cruz says he's going to appoint rock rib conservatives with a paper trail. What are you going to do?
TRUMP: Well, I'm going to appoint conservative judges. I'm going to appoint people that have great reputations, that are great with the legal profession…
STEPHANOPOULOS: Like?
TRUMP: Well, I can say like any — you know a judge who is a totally underrated and not spoken is Justice Thomas. I mean, if you look at — if you look at some of the judges that we have like on the Supreme Court, Justice Roberts turned out to be a nightmare for conservatives. I mean…
STEPHANOPOULOS: But how are you going to…
TRUMP: Wait, let me first say. Ted Cruz, was the one that really wanted Justice Roberts to go on the Supreme Court. You know that, right? Have you heard that? Let me just say, he was pushing him hard. Justice Roberts gave us Obamacare. Obamacare would have been terminated twice if it weren't for Justice Roberts. First time, 100 percent, second time 90 percent it would have died of its own weight. But Justice Roberts could have killed Obamacare, and should have, based on everything. Should have killed it twice. Ted Cruz is the one that was promoting him. Ted Cruz and also Jeb Bush. But Justice Roberts was the man that gave us — and remember it — he gave us Obamacare almost as much as Obama himself.
Thomas Valentine is a researcher for the American Principles Project and a junior at the Franciscan University of Steubenville.
CategoriesCandidate, Commentary, Donald Trump, Social Issues, Ted Cruz Tagsabortion, Donald Trump, marriage, Supreme Court, Ted Cruz
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Pursuing trifles, anguished, forgetful of life's grace.
The farther from this downslide, the more you feel alive.
The yearning for competing is fading to the past.
As Shen Yun brings the singers with Buddhas side by side.
Stentorian the tenors, sopranos' brilliance thrills.
Of every heart that listens, which beaming peace now fills.
When breathing the compassion sent out with every line.
The future's brilliance – dazzling, the Truth draws near… behold!
Daniel Magdalen is a graduate student in the Faculty of Letters at the University of Bucharest, in Romania.


text:
Q: Giving Google Cloud Function Access to Google Cloud Bucket I am trying to set up IAM permissions so that a function can access one of my buckets, but I can't seem to get it to work. What I did was go to the details page on my function and copy the service account of the function:
image of console page
I then took that service account to the bucket page, then clicked "grant access", pasted in the service account as my principal, and gave it "storage admin" and "storage legacy bucket reader" as its roles:
google storage bucket grand access page
Yet I still get an error as my function doesn't seem to have access to the bucket.
For reference, the bucket contains a tensorflow.js model, and everything works fine when I set my bucket to public.

redpajama_set_name: RedPajamaStackExchange


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News » Spirits news
World's 50 Best Bars Brands Report 2015
By Hamish Smith
Published: 06 January, 2015
Welcome to the World's 50 Best Bars Brands Report 2015, a spin-off survey that tells us what brands sell best in the best bars in the world.
We've spoken to 38 of the World's 50 Best Bars for this poll and in order to have a broad set of results we widened the net to include responses from a total of 100 of the top bars in the world - as voted for by our World's 50 Best Bars Academy.
We asked bar owners and head bartenders from these 100 top bars to name the Best Selling and Top Trending brands behind their bars. For more information about our methodology see here.
Starting with Bartenders Choice (bartenders' personal picks) day by day we will take you through the overall Best Selling and Top Trending spirits, and into the categories - from tequila, gin, vodka, rum, liqueurs, Scotch, World Whiskies, Brandy, aperitifs and digestifs,champagne, beer, water and tonic water to the best brands for cocktails.
BARTENDERS' CHOICE
Yes, that is a mezcal topping our top ten spirits list. Perhaps we shouldn't be surprised – this stuff is catnip to the bartending fraternity and Del Maguey is the brand that prompted the feeding frenzy.
Since we've been asking bartenders what they prize most, the list has generally been topped by big but quality-oriented brands such as Tanqueray and Havana Club, so a minnow entering the list at number one is some achievement.
Artist Ron Cooper founded Del Maguey in 1995 with a vision to show the world the best of the Mexican spirit. His organic Single Village Mezcal concept draws on age-old techniques and knowledge and showcases the individual terroir of each village.
Bartenders who took part in the survey are convinced. The American Bar in London told us Del Maguey was "reflective of an area and culture", while Milan's Rita & Cocktails said the brand has the best "connection of any product to the terroir".
Bartenders tell us they love the range's multitude of single-village mezcals and different agave types, and are happy to take them down naked or chasing a beer. But the expression that has really plugged a gap no one knew they had is Vida – the first entry level, mixable mezcal.
Junipery gin giants Tanqueray and Beefeater are linchpins of the list and come in second and third places. Speaking of Tanqueray, Barcelona's Ohla Boutique Bar described it as "one of the best gins in the world", while Imperial Craft in Tel Aviv call it the "perfect white spirit".
But that's not it for gin – there are four in our top 10. St George at six is a range of three craft gins produced in California and at 10 we have the German craft gin Monkey 47, which is bottled at 47% and includes 47 ingredients. It's a brand that has been proving more is more in Germany for a couple of years and is now an established favourite around the world.
At number four is Plantation rum which, according to Berlin's Curtain Club, offers "wonderful variety in its portfolio" that makes "every guest's night at the bar memorable".
Perhaps Bacardi, traditionally more of a volume brand, is a surprise inclusion, but rum is hot and Bacardi's aged expressions have better exposure than smaller rums.
The tequila branch of the agave family also gets a nod from our bartenders. Though dropping from second place last year, Tapatio is a firm favourite behind the stick. It is produced at the La Alteña distillery in the highlands of Jalisco – the same place that makes Tomas Estes' Ocho, which narrowly missed the Top 10 this year.
The World's 50 Best Bars Brands Report 2015: Cocktails
Gin is extremely uninteresting
Brands Report 2020: Rum
Franck Dedieu named St-Germain ambassador


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Sample Name: Coarctation of Aorta
Description: Juxtaductal coarctation of the aorta, dilated cardiomyopathy, bicuspid aortic valve, patent foramen ovale.
HISTORY: The patient is a 4-month-old who presented with respiratory distress and absent femoral pulses with subsequent evaluation including echocardiogram that demonstrated severe coarctation of the aorta with a peak gradient of 29 mmHg and associated dilated cardiomyopathy with fractional shortening of 16%. A bicuspid aortic valve was also seen without insufficiency or stenosis. The patient underwent cardiac catheterization for balloon angioplasty for coarctation of the aorta.
PROCEDURE: After sedation and general endotracheal anesthesia, the patient was prepped and draped. Cardiac catheterization was performed as outlined in the attached continuation sheets. Vascular entry was by percutaneous technique, and the patient was heparinized. Monitoring during the procedure included continuous surface ECG, continuous pulse oximetry, and cycled cuff blood pressures, in addition to intravascular pressures.
Using a percutaneous technique a 4-French 8 cm long double lumen central venous catheter was inserted in the left femoral vein and sutured into place. There was good blood return from both the ports.
Using a 4-French sheath a 4-French wedge catheter was inserted into the right femoral vein and advanced through the right heart structures out to the branch of pulmonary arteries. The atrial septum was not probe patent.
Using a 4-French sheath a 4-French marker pigtail catheter was inserted into the left femoral artery and advanced retrograde to the descending aorta ,ascending aorta and left ventricle. A descending aortogram demonstrated discrete coarctation of the aorta approximately 8 mm distal to the origin of the left subclavian artery. The transverse arch measured 5 mm. Isthmus measured 4.7 mm and coarctation measured 2.9 x 1.8 mm at the descending aorta level. The diaphragm measured 5.6 mm. The pigtail catheter was exchanged for a wedge catheter, which was then directed into the right innominate artery. This catheter was exchanged over a wire for a Tyshak mini 6 x 2 cm balloon catheter which was advanced across the coarctation and inflated with complete disappearance of discrete waist. Pressure pull-back following angioplasty, however, demonstrated a residual of 15-20 mmHg gradient. Repeat angiogram showed mild improvement in degree of aortic narrowing. The angioplasty was then performed using a Tyshak mini 7 x 2 cm balloon catheter with complete disappearance of mild waist. The pigtail catheter was then reintroduced for a pressure pull-back measurement and final angiogram.
Flows were calculated by the Fick technique using an assumed oxygen consumption.
Cineangiograms were obtained with injection in the descending aorta.
After angiography, two normal-appearing renal collecting systems were visualized. The catheters and sheaths were removed and topical pressure applied for hemostasis. The patient was returned to the pediatric intensive care unit in satisfactory condition. There were no complications.
DISCUSSION: Oxygen consumption was assumed to be normal. Mixed venous saturation was low due to mild systemic arterial desaturation and anemia. There is no evidence of significant intracardiac shunt. Further the heart was desaturated due to VQ mismatch.
Phasic right-sided pressures were normal as was the right pulmonary artery capillary wedge pressure with the A-wave similar to the normal left ventricular end-diastolic pressure of 12 mmHg. Left ventricular systolic pressure was mildly increased with a 60 mmHg systolic gradient into the ascending aorta and a 29 mmHg systolic gradient on pressure pull-back to the descending aorta. The calculated flows were mildly increased. Vascular resistances were normal. A cineangiogram with contrast injection in the descending aorta showed a normal left aortic arch with normal origins of the brachiocephalic vessels. There is discrete juxtaductal coarctation of the aorta. Flow within the intercostal arteries was retrograde. Following balloon angioplasty of coarctation of the aorta, there was slight fall in the mixed venous saturation and an increase in systemic arterial saturation as the fall in left ventricular systolic pressure from 99 mmHg to 92 mmHg. There remained a 4 mmHg systolic gradient into the ascending aorta and 9 mmHg systolic gradient pressure pull-back to the descending aorta. The calculated systemic flow fell to normal values. Final angiogram with injection in the descending aorta demonstrated improved caliber of coarctation of the aorta with mild intimal irregularity and a small left lateral filling defect consistent with a small intimal tear in the region of the ductus arteriosus. There is brisk flow in the descending aorta and appropriate flow in the intercostal arteries. The narrowest diameter of the aorta measured 4.9 x 4.2 mm.
DIAGNOSES:
1. Juxtaductal coarctation of the aorta.
2. Dilated cardiomyopathy.
3. Bicuspid aortic valve.
4. Patent foramen ovale.
INTERVENTION: Balloon dilation of coarctation of the aorta.
MANAGEMENT: The case will be discussed at combined Cardiology and Cardiothoracic Surgery Case Conference. The patient will be allowed to recover from the current intervention with the hopes of complete left ventricular function recovery. The patient will undoubtedly require formal coarctation of the aorta repair surgically in 4-6 months. The further cardiologic care will be directed by Dr. X.
Keywords: cardiovascular / pulmonary, coarctation, juxtaductal, dilated cardiomyopathy, bicuspid aortic valve, patent foramen ovale, catheter was inserted, mmhg systolic gradient, mmhg systolic, systolic gradient, descending aorta, catheterization, mmhg, ventricular, aorta, aortic, foramen,


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Bryant to seek stay of HB 1523 ruling
Gov. Phil Bryant has given notice of an appeal of a federal judge's ruling blocking House Bill 1523.
Bryant to seek stay of HB 1523 ruling Gov. Phil Bryant has given notice of an appeal of a federal judge's ruling blocking House Bill 1523. Check out this story on clarionledger.com: http://on.thec-l.com/29BNFAs
Jimmie E. Gates, The Clarion-Ledger Published 9:35 a.m. CT July 8, 2016 | Updated 7:37 p.m. CT July 8, 2016
Derrick Johnson, state director for the NAACP, speaks on the steps of the Capitol in downtown Jackson following the blocking of HB 1523 by a federal judge.(Photo: File photo/The Clarion-Ledger)
Gov. Phil Bryant has given notice of an appeal to the 5th U.S. Circuit Court of Appeals of a federal judge's ruling blocking House Bill 1523.
In a motion filed Thursday in U.S. District Court, Bryant's attorney, Drew Snyder, asked that U.S. District Judge Carlton Reeves stay his preliminary injunction, pending appeal.
"Although we respect this court and its decision, we believe that the court's preliminary-injunction order is unlikely to survive appellate review," Snyder said. "First, none of the plaintiffs has standing to challenge HB 1523. Second, HB 1523 is constitutional — and it is indistinguishable from federal statutes that protect the conscientious scruples of pacifists and abortion opponents. ... Third, the court erred by refusing to sever the discrete provisions of HB 1523 and by failing to leave in force section 3(1)(a), which even this court admitted was constitutional."
Last week, only minutes before HB 1523 was set to go into effect July 1, Reeves issued an opinion blocking the measure.
"This is a good law that was democratically enacted and is perfectly constitutional," Bryant said Friday in a statement. "The district court's decision is ripe for reversal and we are confident that, as this case moves ahead it will be reversed. The people of Mississippi have the right to ensure that all of our citizens are free to peacefully live and work without fear of being punished for their sincerely held beliefs. And as governor, it is my duty to uphold my oath to defend the people of Mississippi and the laws passed by those entrusted to represent them."
JUDGE RULING ON HB 1523: read story
In a 60-page opinion, Reeves said that, through HB 1523, the state grants privileges to people who hold certain moral convictions which "violates both the guarantee of religious neutrality and the promise of equal protection of the laws."
The order came days after Reeves has blocked part of bill when he issued a permanent injunction barring Mississippi from denying same-sex marriage licenses.
Bryant is making good on his promise to appeal Reeves' decision.
"Like I said when I signed House Bill 1523, the law simply provides religious accommodations granted by many other states and federal law," Bryant said last week. "I am disappointed Judge Reeves did not recognize that reality. I look forward to an aggressive appeal."
The plaintiffs argued in the federal constitutional challenge to House Bill 1523 that by the Legislature passing the bill and Bryant signing the legislation, it breached the separation of church and state and specifically endorsed and provided special protections for specific religious beliefs and moral convictions that:
Gov. Phil Bryant has filed notice of appeal of a federal judge's ruling striking down HB 1523. (Photo: File photo/The Clarion-Ledger)
Condemn same-sex couples who get married.
Condemn unmarried people who have sexual relations.
Condemn transgender people.
"The bill was enacted to promote, endorse and provide special protection for these particular beliefs and convictions," said Jackson attorney Rob McDuff, who along with the Mississippi Center Justice, represent a group of citizens in the lawsuit.
McDuff said HB 1523 also targets for disfavor and unequal treatment and is the result of animus toward the particular individuals and groups who are condemned by these beliefs and convictions. "There is no rational basis for the discriminatory treatment of those who are disfavored by the state through HB 1523 and no rational basis for exclusively endorsing and providing special protections for those people who subscribe to these beliefs and convictions," McDuff said.
The plaintiffs alleges HB 1523 violates the First and Fourteenth Amendments to the Constitution.
Contact Jimmie E. Gates at 601-961-7212 or jgates@jackson.gannett.com. Follow @jgatesnews on Twitter
Read or Share this story: http://on.thec-l.com/29BNFAs


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Dealmakers
New £25m fund to help management teams acquire SMEs in Wales
The Welsh Government's new Wales Management Succession Fund is being managed by Finance Wales
Sion Barry
A new £25m fund to support management buy-outs of high growth potential small and medium-sized firms in Wales has been launched.
The new Wales Management Succession Fund from the Welsh Government is being managed by Finance Wales.
Over the next five years, the fund aims to back Welsh management teams at 20 SMEs to investment and growth their businesses. It is forecasting to create and safeguard 1,000 jobs under new ownership.
The funding, both debt and equity, will range per deal from £500,000 to £3m. Under it now fully invested £150m Jeremie Fund, the most that Finance Wales could invest per deal was £2m.
Related new:Finance Wales appoints new chairman
Finance Wales has already made succession investments totalling £42m from its existing funds to help new owners buy 127 established Welsh SMEs and demand for this type of investment has increased in the last three years.
Finance Wales
Giles Thorley chief executive of Finance Wales
Giles Thorley, Finance Wales' new chief executive , said: "The Wales Management Succession Fund is yet another demonstration of the Welsh Government's commitment to Welsh SMEs.
Between 2012 and 2016 the Welsh Government has made over £120m of growth finance available to Finance Wales to invest in a range of funding requirements.
"Finance Wales can now provide ambitious Welsh managers and management teams with tailored funding packages to buy their own businesses."
Edwina Hart
Minister Edwina Hart
Business Minister Edwina Hart said: "Established small and medium-sized businesses have skilled, loyal workforces and make a significant contribution to the Welsh economy. They have often traded successfully for many years and have the potential to achieve even greater success in future.
"With an increasing number of Welsh business owners looking to retire or sell their businesses, the Wales Management Succession Fund will provide aspiring new owners with the funding they need to buy these indigenous businesses and drive them on to even greater success."
Finance Wales, which is wholly-owned by the Welsh Government. is also bidding to run a successor fund to Jeremie, the £136m Wales Business Fund.
The new fund is not expected to draw down any external commercial funding. The National Procurement Service for Wales is overseeing the procurement process.
The Jeremie Fund included £75m in a repayable loan to the European Investment Bank (EIB). At an interest rate of just over 3% that meant it was passed on by Finance Wales in the interest it charged on loans to SMEs.
Without the repayment of interest and capital to the EIB it should allow Finance Wales to significantly reduce the interest rates it charges on debt under the new fund.
The successful bidder to run and manage the fund is expected in June.
Follow @BusinessinWales
NewportLiberty Steel Group announces it is cutting jobs in WalesIt is understood that around 70 workers in Newport will be affected
Your MoneyMoney Saving Expert Martin Lewis reveals simple way to save £1000s in new yearThis could be the answer to your financial woes
BangorThe Book People goes into administration a week before ChristmasThe company employs 229 people in Bangor
Business NewsThe shortlist for the West Wales Business Awards 2020 has been revealedThe event takes place in January next year
CardiffNew pictures show plans to transform former Brains Brewery site into bars and restaurantsThe former brewhouse development will form part of the Central Quay scheme in Cardiff city centre


text:
Q: Switch for bitwise comparison I found just one entry for the keywords "bitwise switch", but I did not manage to use it because the example was written in C. In PHP I am using the following function:
function flags2string($flags) {
    $title = Array();
    switch(true) {
        case (MYSQLI_NOT_NULL_FLAG & $flags):
            $title[] = 'Not null';
        case (MYSQLI_PRI_KEY_FLAG & $flags):
            $title[] = 'Primary';
        case (MYSQLI_UNIQUE_KEY_FLAG & $flags):
            $title[] = 'Unique';
        case (MYSQLI_NUM_FLAG & $flags):
            $title[] = 'Number';
        break;
        default:
            $title[] = 'Other';
    }
    return implode(', ', $title);
}

However, it collects either just one value or, without breaks, all of them. How can I solve this issue?


A high quality inclined counterknife designed for the Vecoplan RG-32 shredders that use 40mm inserts. Made from high grade tool steel, perfectly hardened to maximize wear life and resist shattering. This is the Right-hand counterknife of a 2 piece set.


text:
If I Were A Boy
the Emmy Pageant
If I were a Boy is the story of a young woman dealing with what it means to be a girl today. The world is different for the young 20 something generation, largely because most women of that age now work, often waiting to get married and have babies, if they decide to have them at all. The very definition of what it means to be a woman is changing. Pop culture presents an interesting place to look at what it now means to be a woman, what it means to be feminine, and consequentially what that all means for everyone else. The story will range from sci-fi, to fashion, to music and even politics, but mostly its going to be about how all of that affects me, and my life as a girl.
Last Sunday, I sat with my roommate and my future other roommate, drinking Bellinis, eating brownies and watching the Emmys. Although most people were disappointed with the Emmy's, I found several successes for women.
Jane Lynch I thought did a good job. She is an interesting woman, who has had an interesting career. Her recent marriage was not brought up, from what I saw, despite the fact that she married long time girlfriend Lara Embry in June. The New York Times offers a beautiful announcement and I read about it in Vogue a few months ago also.
Lynch is typically thought of as being fairly "˜butch', a trait further emphasized by Lynch's portrayal of Sue Sylvester in Glee. However throughout the Emmys Lynch dazzled in ball gown after ball gown, I only saw her in one suit while she was accompanied by the self-mocking Paula Abdul. The fact that Lynch blurs traditional gender stereotypes in her acting, yet is comfortable presenting TV's best night in ball gowns, is an interesting feat. She portrays competitive, intense, angry and aggressive women on some screens, yet shines in and sings in feminine gowns and skirts at other moments. Lynch definitely provides an interesting case study in gender portrayal.
However my favorite moment in the Emmy's did not feature Lynch. Like most people, my favorite part was when Amy Poehler jumped on stage, prom or pageant style, after they announced her nomination in the Outstanding Lead Actress in a Comedy Series category. The five other nominees quickly followed her on stage as their names were read, leaving my viewing partners to ask if the event was planned or an impromptu example of Poehler and other female comedians' genius.
However I was less concerned with the planned nature of the act, and instead was entertained by the comedians on stage. They hugged each other in nervousness and welcome as each new name was called. They held hands while all wore long ball gowns, evoking images of pageants and the stereotypical high school prom.
When Mellissa McCarthy took home the well deserved win, they all hugged her and seemed truly happy to be on stage and share her joy. There were no tears or fake smiles like you would see in pageants or prom night, these incredible women recognized that McCarthy's victory did not mean their loss.
And furthermore, as McCarthy received flowers and a fake crown, I realized this comedic but touching stunt could not have been pulled off by men. Men going on stage as their nomination is announced would seem fake and pushed. Only women could evoke the pageant imagery, both mocking and embracing it simultaneously.
McCarthy's tears of shock and joy during her acceptance speech were also touching. She fully admitted to them, calling herself "a crier"(A trait I commiserate with as my face starts uncontrollably leaking far more often then I would like). But these tears could also not have been able to be pulled of by a man. Sure men cry during acceptance speeches, men get nervous and seem obviously overwhelmed by their victory. But tears on women still humble them in a way men have to go to big lengths to invoke.
Women are allowed to use a sensitivity that can make them seem more real. Sure, seeing my father cry for the first time shocked me by the fact that he could be hurt and saddened. But seeing a celebrity, an idol, a role model for young girls, up on stage unable to hold back tears as an example of her "feminine weakness" makes her seem more real to me. It shows me the real shock they have in winning.
Women in general cry more, and tears on women are far more acceptable in society today. But when I see a female celebrity crying, I see her as a woman first and a celebrity second. It humanizes these idols, and shows how they can have real feelings. Because it is still generally a taboo for men to cry, seeing a man crying on screen can seem fake and forced. It does little to humanize or humble them.
While these comedic goddesses all stood on stage together like beauty pageant queens, they used a female stereotype to show how far women have come. These women are not the best in their field because they are the most beautiful women today (although they all are truly stunning in their own diverse way). Instead they were being recognized for being hilarious, clever and witty. Arguably these women are funnier than the men nominated for Outstanding Lead Actor in a Comedy Series, and the stunt they pulled at the Emmys only shows how funny women can be.
Check out more If I Were a Boy here
Sam's Top Ten Films of 2014
Jordan's Film Awards Ballot
Jordan's Television Awards Ballot
Darrens Musical Radar (Part 2 - 2014)
Game of Thrones: Season 4, Episode 10
Running with The Doctor
Game of Thrones: Season 4, Episode 9
Recent Articles By Becky
Tweets by @Reviewtobenamed
© 2021 by Review To Be Named. All rights reserved.


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Fungicides are not registered for use on industrial hemp for any disease. Research is required to determine the efficacy of the products and timing of application. Crop rotation is the best cultural practice to avoid disease build-up. A four year rotation away from a similar crop is recommended.
Sclerotinia sclerotiorum (white mold) and Botrytis cinerea (grey mold) are common molds and the most serious diseases affecting industrial hemp.
The fungus sclerotinia occurs in all areas of Canada where canola, sunflowers, edible beans and soybeans are grown. The severity of sclerotinia stem rot is variable from year to year, region-to-region and even from field to field. The incidence of sclerotinia has risen as the acreage of similar broad-leafed crops increases. Management practices that contribute to high yields also produce dense canopies, which creates a microclimate for disease development. Wet, warm weather patterns also favor disease development.
The hard, black sclerotia overwinter in the soil where they can remain viable for more than five years. Short rotations of host crops will increase the number of sclerotia in the soil. Warm, moist soils conditions that last for at least 10 days encourage the development of apothecia (small mushroom like growths) from the sclerotia. A heavy canopy keeps the soil surface moist and creates ideal conditions for the apothecia to grow and release the spores. Under ideal conditions, the apothecia can continue to develop until late September. Infection of host plants occurs from airborne spores produced by the sclerotia in the soil.
The spores are spread by the wind for several kilometres. Insects such as honey bees can also carry spores. Crop rotation is one of the best forms of defense in hemp to date, but dependant on the crops grown in the area, the field can still have severe infestation regardless of the field rotation.
Spores will infect the stem and the grain head in hemp. Moist conditions from rainfall, high relative humidity and warm temperatures increase the spore survival and growth.
The bracts in the hemp head create ideal conditions and food for survival and development of the ascospores (early apothecia). The denser the head, often the more severe the infection of the hemp crop under ideal conditions. Humid conditions and temperatures between 20° and 25°C encourage growth. Dry conditions can slow down or stop development. During harvest, the sclerotia are either returned to the soil to continue the disease cycle or are removed from the field in the grain sample.
When sclerotinia develops in the stem, it will cause premature ripening or in the early stages of plant development will kill the plant. The black sclerotia generally form on or inside the hemp stalk.
The sclerotia are generally in the bottom one third of the stem so they are often cut off at harvest and do not contaminate the grain sample.
Sclerotinia damage is greatest when it affects the hemp head.
The sclerotia will form anywhere along the grain head. Everything above the point of infection on the head dies. Sclerotia form at the site of infection. During harvest these sclerotia bodies are a part of the grain sample. The sclerotia bodies are very difficult to remove when cleaning the seed. Larger ones can be screened out but the sclerotia are brittle and will break down into small pieces similar in size to hemp seed. The sclerotia can only be removed to some extent with gravity tables and colour sorters and there will be a significant amount of grain lost due to the these cleaning methods. Sclerotia bodies are not desirable in one of the end uses of hemp, hulled hemp and can lead to rejection of the grain sample by the processor.


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How global financial crisis of 2008 hurt liberal democracy, open borders
Home How global financial crisis of 2008 hurt liberal democracy, open borders
Exactly ten years ago on 15 September 2008, the dream run of the world economy came undone with the collapse of Lehman Brothers revealing a rotten scaffolding of financial skulduggery underneath it. Lehman's failure had been the inevitable fallout of a systemic economy-wide pattern of irresponsible lending financed through issuance of exotic new financial instruments that had fuelled the American housing market for years. When the music finally stopped as property prices fell, and the loans and securities linked to the real estate market became worthless, all hell broke loose. The world's worst economic crisis since 1929 ensued. The previous decade has been all about returning to the normalcy of the pre-Lehman days. There have, however, been little successes.
Debt, which had been the linchpin of the 2008 crisis, has continued to grow contrary to expectations mainly led by government borrowing across the world. A recent McKinsey report calculated that the combined global debt of governments, non-financial corporations and households has ballooned by $72 billion since the end of 2007. Quite interestingly, the Chinese economy accounts for more than a third of the global debt growth since the financial crisis. On a related note, as central banks around the world had kept interest rates low to encourage lending and boost growth, corporate debt levels have doubled since the crisis. This has been especially true for the developing world. As for the household sector, which was directly connected to the crisis, debt levels have fallen for the United States and Europe but has risen elsewhere.
The world economies did manage to stabilise the global financial system with such policies of burdening sovereign balance sheets, lowering interest rates, and widening fiscal deficits. But all of these moves only amounted to a weak recovery over the decade. This has been a failure of the field of economics more than anything else. The legacy of the global financial crisis could have been the re-thinking of the market economy. But little changed. A paltry of bankers were shown the door and a few institutions were levied with fines and penalties. Eventually, most of the burden was borne by the state or the shareholders.
To be fair, regulations were strengthened for banking institutions. They have to hold more capital and employ an army of compliance officers. Nevertheless, there has been no solution to the problem of too-big-to-fail institutions. Taxpayers will still have to bear the brunt of the next crisis. Just as before, profit is privatised but the risk is nationalised. The lack of unique policy recommendations from the economists has been deafening in the post-Lehman years. This has been in complete contrast to the previous major global crises.
While the post-war period saw a sustained period of robust growth on account of the successes of Keynesian economics, the post-1960s world shifted to a greater reliance on markets led by free-marketeers like Milton Friedman. The world failed to see any such shift in economic thinking after 2008. Policy-makers seem to be simply fidgeting to find the right balance between "free markets" and "government intervention".
An unfortunate change that did occur after the crisis, however, has been the rise in populism around the world. In a world with widening income disparities where growth is skewed at the top while incomes stagnate or fall for the rest with no respite in sight, a toxic rhetoric that makes fanciful promises of reinstating past glory rings a bell with the voters even if more is usually said than done. In the process, more and more people have grown averse to the idea of laissez-faire and globalisation, especially in the advanced countries. Thus, liberal democracy and open international borders have been the biggest victims of the 2008 financial crisis.
Sooner or later the field of economics will have to rethink the way the world works. The status quo is an uncomfortable one. The current economic system has become highly rent-seeking behind the facade of free markets; a system that is highly rewarding for the politically connected insiders. The establishment's complacency for change has built up rage among those who have been left behind in the process, which has materialised in elected leaders that have successfully managed to tap into this sense of unfairness. If the field of economics does not deliver soon as it did repeatedly in the twentieth century, a challenging future lies ahead for the world economy. Thomas Paine once wrote at the beginning of the American Revolution, "We have it in our power to begin the world over again." Hopefully economists find the same conviction soon enough.
The article was published with Business Standardand Daily Hunton September 11, 2018.
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