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Health Logic Interactive Receives Letter of Support from the Director of the Kidney and Blood Pressure Center at Tufts Medical Center
CALGARY, AB, June 29, 2021 /CNW/ – Health Logic Interactive Inc. ("Health Logic" or the "Company") (TSXV: CHIP.H) (OTCPK: CHYPF), is pleased to announce its wholly-owned operating subsidiary, My Health Logic Inc. ("My Health Logic"), has received a letter of support for the Company's chronic kidney disease (CKD) technology from Lesley A. Inker, M.D. MS. Dr. Inker is the Director of the Kidney and Blood Pressure Center at Tufts Medical Center, an Associate Professor of Medicine at Tufts University School of Medicine and a valued member of the Company's scientific advisory board (the "SAB"). This letter supports the Company's belief that its lab-on-chip device for the early detection of CKD has the potential to address a large and unmet need of patients who have, or are at risk for developing, CKD.
In her support letter, Dr. Inker, a recent addition to the SAB, stated, "…this proposed device represents a major innovation in prevention of CKD. Assessment of GFR (glomerular filtration rate) is an essential part of many clinical decisions and having easy access to GFR measurements at home or at the point of care could be transformative. Critically, you are considering the health delivery platform in addition to the technology. The software on a patient's personal devise could allow access to this information at every health encounter and even at home. Together, your vision for the landscape of kidney assessment tools could have considerable benefits to our patients, providers and health care systems."
When asked about the support letter, Dr.Rigatto, the Chief Medical Officer of My Health Logic and one of the co-founders of the Company's lab-on-chip technology, stated that "according to the Centers for Disease Control and Prevention, more than 1 in 7 adults in the United States are estimated to have CKD and as many as 9 in 10 adults with CKD do not know they carry the disease.1 We believe that our technology can shrink this testing gap and help identify high risk patients earlier for better disease prevention and progression. I am delighted that Dr. Inker shares our vision for improving screening and treatment options for patients."
1 "Chronic Kidney Disease in the United States," Centers for Disease Control and Prevention, 2021.
https://www.cdc.gov/kidneydisease/publications-resources/ckd-national-facts.html.
Health Logic Interactive, through its wholly owned operating subsidiary My Health Logic, is developing and commercializing consumer focused handheld point-of-care diagnostic devices that connect to patient's smartphones and digital continued care platforms. The Company plans to use its patent pending lab-on-chip technology to provide rapid results and facilitate the transfer of that data from the diagnostic device to the patient's smartphone. The Company expects this data collection will allow it to better assess patient risk profiles and provide better patient outcomes. Our mission is to empower people with the ability to get early detection anytime, anywhere with actionable digital management for chronic kidney disease. For more information visit us at: www.healthlogicinteractive.com
Further information regarding Health Logic Interactive Inc. and its disclosure documents are available on SEDAR at www.sedar.com.
Cautionary Notes
Certain statements contained in this press release constitute "forward-looking statements". All statements other than statements of historical fact contained in this press release, including, without limitation, those regarding the Company's belief that the device has the potential to address a large and unmet need of patients who have, or are at risk for developing, CKD, the expected benefits of the device for patients, providers and the health system, the ability of the Company's technology to shrink the testing gap and identify high risk patients earlier, the potential of the device to make screening feasible at every health encounter and potentially at home, and the Company's strategy, plans, objectives, goals and targets, and any statements preceded by, followed by or that include the words "believe", "expect", "aim", "intend", "plan", "continue", "will", "may", "would", "anticipate", "estimate", "forecast", "predict", "project", "seek", "should" or similar expressions or the negative thereof, are forward-looking statements. These statements are not historical facts but instead represent only the Company's expectations, estimates and projections regarding future events. These statements are not guarantees of future performance and involve assumptions, risks and uncertainties that are difficult to predict. Therefore, actual results may differ materially from what is expressed, implied or forecasted in such forward-looking statements. Additional factors that could cause actual results, performance or achievements to differ materially include, but are not limited to the risk factors discussed in the Company's Management's Discussion and Analysis for the year ended December 31, 2020. Management provides forward-looking statements because it believes they provide useful information to investors when considering their investment objectives and cautions investors not to place undue reliance on forward-looking information. Consequently, all of the forward-looking statements made in this press release are qualified by these cautionary statements and other cautionary statements or factors contained herein, and there can be no assurance that the actual results or developments will be realized or, even if substantially realized, that they will have the expected consequences to, or effects on, the Company. These forward-looking statements are made as of the date of this press release and the Company assumes no obligation to update or revise them to reflect subsequent information, events or circumstances or otherwise, except as required by law.
SOURCE Health Logic Interactive Inc.
For further information: George Kovalyov, Director, info@healthlogicinteractive.com, 1-877-456-4424.
Categories News Release Post navigation
Health Logic Interactive Announces Proof-of-Concept Test Results and Advancement of its Lab-on-Chip Technology
Health Logic Interactive Provides Product Update for MATLOC 1 Digital Diagnostic Device
Health Logic Interactive Announces The Closing Of Its Sale Of Its Wholly Owned Subsidiary
Health Logic Interactive Announces the Resignation of CEO and Appoints New Interim CEO to Focus on New Acquisition Targets
Health Logic Interactive Enters into Arrangement Agreement with Marizyme to Sell Wholly-Owned Operating Subsidiary
Health Logic Interactive Provides Product Update for MATLOC 1 and Update on Its FDA Pre-Submission Meeting
TSXV-CHIP.H OTC-CHYPF
© 2022 Health Logic Interactive Inc, All Rights Reserved


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BSF Police News
High alert in place by Security Agencies for Independence Day celebrations
New Delhi: The Delhi Police has made elaborate arrangements for the 73rd Independence Day celebrations to prevent any untoward incidents from occurring as there had been an increased threat perception in the wake of the Kashmir crisis. A senior police officer said as the threat perception on August 15 is high due to the prevailing situation precautionary measures has been taken by taking the necessary tie-ups with the crack units like National Security Guard, Special Protection Group and Indo-Tibetan Border Police. The Police officer said, in accordance with the security arrangements that have been put in place which is multi-level in nature include the deployment of 20,000 Delhi Police officers and all the security agencies will be working in close relationship with each other. The SWAT teams and Parakram vans also have been strategically stationed. The State police have also initiated the installation of over 1,000 cameras across the districts. At strategic locations special facial-recognition cameras have also been installed. Other security teams such as Anti-drone detection teams, rooftop deployment and snipers have also been put in place. Importance has been given to the aerial space over Red Fort as the Security Officers will also ensure that it remains clear. Metal detectors were also used for the Multi-layer checking during the Independence Day function. The Police officer said in addition to the security arrangements at the main venue at Red Fort, sufficient security arrangements for the function at the Rashtrapati Bhawan have also been organized. A citywide alert had been exercised by the DCPs of all districts. A high level of surveillance has been put in place at the route to Red Fort and the route through which the VIPs and dignitaries will cross.]]>
Director General of Police appreciates Tamil Nadu Police Force
Thu Aug 15 , 2019
From Bharatpur Jail an Undertrial Uploads Photos on FB
Mr.Parambir Singh IPS New Commissioner of Police appointed for Mumbai
Praveen Samuel March 1, 2020
Mr. Anjani Kumar IPS told Precautions need to be taken to avoid Corona
Praveen Samuel March 13, 2020
Mr. Himanshu Mishra IPS gives the 7 Mantras of Corona
Sand mafia gang busted by Ghatkesar Police and LB Nagar Zone Police of Rachakonda Commissionerate
Praveen Samuel July 20, 2020
Bhubaneswar Police action on Human Trafficking
Praveen Samuel January 11, 2022

redpajama_set_name: RedPajamaCommonCrawl


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Share Her She Shed? She Said, "Sure."
Self-sufficiency! It's admirable, right? "Do-it-yourself" may once have been a wisecrack (as in, "If you want it done right…"), but these days it's a back-to-basics virtue and, in more and more circumstances, a necessity for getting on with life. (Also, a popular TV channel).
That is the context within which to imagine Lisa Bieringer, Managing Principal at O+A, standing outside an evil-smelling shack in Marin County determined to make it habitable. "One day I just took a crowbar and said, 'That's it. I'm doing it myself. I'm going in.'" As she ripped the interior "down to the studs," she discovered what DIY fans learn in every episode: if it's bad on the surface, it's worse underneath. "I mean, it was literally raining ants," she says. "There were dead things in the walls; there was a petrified squirrel under the floorboards. It was nasty."
Freeze frame here for a little backstory.
Lisa has always loved to sew. As a kid in school, she made clothes for her friends. She made summer shorts, formal dresses, and costumes for her cheerleading team. "When I moved to California," she says, "I got rid of my car and only took a few things with me. I took my bike, my clothes, and my sewing machine."
For all its DIY rectitude, sewing is not a tidy operation—at least not the way Lisa does it. The fabrics, the patterns, the spools of thread all generated clutter when more than one project was in the works. These accumulating heaps sometimes sparked what we'll call aesthetic differences between Lisa and her fastidious husband Kevin. "The joke was always, are you a filer or a piler?" she says. "He's a filer and I'm a piler." She needed her own place to sew.
For a while, she'd had her eye on an unused shed on the grounds of their home in Stinson Beach. The partially boat-shaped structure had once been a duck blind on the Bolinas Lagoon and had a raffish reputation for having served occasionally as a local love shack. "When we bought the place and went in there, someone had been living in it with three Labs and a girlfriend," she says. "There were fleas everywhere. I mean, it was not usable." Those conditions put shed conversion at the bottom of the DIY project list, but over time, as Lisa's sewing piles grew higher…
End freeze frame with the sound of splintering wood.
"The minute Kevin saw me ripping stuff apart, he got a little jealous," Lisa says, "and was like, Okay, I'll help you with this part." Kevin is an accomplished DIY-er himself and the person Lisa credits with teaching her carpentry. "He built a woodshed," she says, "but it wasn't just any woodshed. It was a Kevin woodshed. And then a little shed for his tools that was very fancy. And then we built an art piece of a fence together." They even pulled the face off of their house—"It looked like a dollhouse!"—and replaced it with NanaWalls. Self-sufficiency!
If those projects were Lisa's carpentry education, the sewing shack (redubbed the "She Shed") became her Master's thesis. At O+A, Lisa is all about meticulous planning and careful oversight, but for her personal space, she and Kevin opted for a kind of jazz riff on existing conditions. "It ended up being design-as-you-go," she says. "Every problem that presented itself, we collaborated on how we were going to solve it. We were stretching materials—like, can we use this product in this way?" Siding material doubling as flooring, windows found on Craigslist. "We kept finding stuff that was on sale, and we would just integrate it into the big design. We didn't know where we were going."
What they ended up with was architectural cool jazz. Lisa's She Shed makes of the shack's original components two distinct spaces. The boat-shaped section which overlooks a creek is, in her words, "blacked out. It's supposed to feel lounge-y." The plywood cube workhouse at the front of the structure "is Scandinavian bright and light for being able to thread needles and do other close work."
Lisa calls the She Shed "my own little universe" and admits when she's away, she can't wait to get back—a gravitational pull so strong even a "neatnik" can feel it. "The other night I saw this flashlight coming from the house," she says, laughing.
Filer coming out to check on his piler.
We are a design studio based in San Francisco.
© Studio O+A
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Rishabh group offers Cloud9 Towers Indirapuram with 2/3 bedroom apartments at very reasonable price along with an excellent view from its majestic height.
• Located next to DPS just off NH-24.
• Fastest developing zone of NCR.
• Ultra modern shopping and entertainment hubs in close proximity i.e. Shipra mall, "D" Mall etc.
• well connected from ISBT and Railway station Anand Vihar.
• Just 1 km from Noida Sec- 62/63 and Fortis hospital.
• Just 5km from Akshardham Temple and commonwealth games village.
GDA approved freehold land, Jain Temple within the complex, Round the clock security with ultra-modern internal communication, 100% power back-up, separate R.O system in each flat, 24hrs water supply from centralized water softening plant, Reticulated cooking gas supply, Clubhouse with swimming pool, modern recreational facilities, well equipped gym, and party lawns, Minimum coverage with maximum green area, Timely possession within 30 month from the start of construction.
Basic Sales Price : Rs. 2690/- per sq.ft.
Special Price: Rs. 2590/- per sq. ft.
Special Discounted Price: Rs. 2390/- per sq. ft.
1 GF, 1st and 2nd Floor Rs 150/- per sq. ft.
2 3rd, 4th, and 5th Floor Rs. 100/- per sq.ft.


Form2 is a fast and flexible electronic form authoring and distribution system for iPad and other mobile devices. The system consists of an online authoring system and app-based completion of distributed forms.
As well as featuring the new Form2 branding, the new app release also features new functionality – namely the ability to include images and short sound files ina form. The existing app will continue to work, though obviously it will not be able to make use of these new features, so users are encouraged to update to version 2.5.0 as soon as possible.
The existing URL (www.eformsapp.com) will continue to direct users to the new site where there will be a login button on the home page to access your account.
A form authoring and distribution system that facilitates the completion of electronic forms on mobile devices.


The Tullis Russell Mills Band was one of many brass bands taking part in today's Fanfare event organised by the Edinburgh International Festival.
The video, shot by Jonathan Riddell, is quite noisy - it's citizen journalism after all - but it captures the scene nicely.
Brass bands played to the general public in various parks and locations across the city, from Balerno on the Southerly outskirts of Edinburgh to the Shore in Leith to the North of the city.
Hats off to the bands that took part!


NEW YORK– Philanthropist, business mogul and five-time Grammy nominated artist Akon has initiated a partnership to reach the Sustainable Development Goals (SDG) by 2030 and assisting participating US states to meet their renewable energy goals. As one of the leading recognized global music brands, Akon has chosen, in the past to address the immediate needs of Africans through an effort known as "Akon Lighting Africa." This initiative addressed the concern that more than two-thirds of the population of sub-Saharan Africa is without electricity, and that more than 85 percent of those living in rural areas lack access. Now, the Akon Corp., in partnership with Reach Construction Group, LLC, is launching Akon Lighting America and has assembled a dynamic group of strategic partners in order to create replicable, scalable and cost-effective utility scale energy solutions and renewable energy solutions for low income housing communities.
As of January 2019, Akon Lighting America will begin developing utility scale renewable energy projects throughout the United States and constructing renewable energy solutions for rural and low income housing communities. "We are extremely proud to launch Akon Lighting America which will enable us to serve and benefit our country – The United States of America – just like we have done in Africa with our ongoing initiative, Akon Lighting Africa. We are pleased by the overwhelmingly positive response of leaders to embrace a public-private partnership that aims to address the SDGs and help them to reach specific goals by 2030. This initiative, Akon Lighting America, is given further importance and momentum based on the support of institutions such as USC Schwarzenegger Institute, Leonardo DiCaprio Foundations and more," said Akon.
Akon Lighting America will team with leaders in the United States to assist in making the United States a leader in meeting the SDG. A comprehensive study by the Department of Energy's National Renewable Energy Laboratory (NREL) shows that the U.S. can generate most of its electricity from renewable energy by 2050.
To date, Akon Lighting America has met with Arnold Schwarzenegger and the USC Schwarzenegger Institute, Leonardo DiCaprio Foundation, and the Mayor of San Diego at the Latest Talanoa discussion to join together in changing the future of our country and its participation in controlling pollution and reducing our total carbon emissions.


California Travel Guide- All the Best Places to See in one amazing state. From someone born & raised there – these are the places you don't want to miss.
Back in the fall I had a work related class to attend in Southern California. Because my son starts college in January we figured it could be the last chance we had to go together on a trip as a family of 5. Also, since all of the family contributes here, I needed their help as I worked while I traveled, so I really did need to take them with me. We could have flown, but since the hubs & I are both California natives we thought it would be an awesome opportunity to show the kids all the wonderful places we love in our home state. We decided to rent an RV & hit the road for 11 days round trip. It was an exciting adventure, I packed in an incredible workshop, got started on writing my latest book while we drove, even created some fun recipes & shared our travel food & got the FULL California experience. Check out all of our top picks for MUST SEE in California.
This was a 3200-mile trek from North Idaho & back & I can tell you if we were to ever do it again – I would get a bigger RV. But in all fairness, we tried. We actually ordered the larger one, that had windows on the side where the kids could look out & see the coast. But unfortunately the people renting it before us didn't return it on time & we were stuck taking the small one or nothing at all at the very last minute. It was a huge bummer – but it worked out. But let's get on to our favorite places.
Glass beach is just south of Ft. Bragg & it was one of the top spots on my list of place to see. We stopped at an Oregon beach the first night but made sure we made it to Ft. Bragg the next so that we could hit up Glass Beach just as the sun came up.
It's basically a collection of tiny bits of sea glass that have taken over the sand. Instead of walking on soft sand, it's like walking on gravel. Only that gravel is bits of glass pebbles in all sorts of colors. It was so beautiful. It was really pretty to see in person.
While we were exploring there we found so many tide pools full of sea creatures to check out. It reminded me of when my girl scout troop visited the tide pools in So Cal when I was a kid. It was something I will remember forever & I was thrilled that my kids got their own taste of this experience there at Glass Beach.
Driving through the Redwoods was probably the most magical part of the entire journey. It's a place like none other in the world & you can't truly comprehend the magnitude of this space until you are there staring up at these trees that have been growing since Biblical times.
We had a long journey ahead of us before we were to reach our spot for the night, so we didn't explore here like I wished we could have. This really is more of a destination, not a pass-through. However, there were plenty of places to pull off & stop for a few minutes. So we took advantage of that & the camera got a workout. It was breathtaking & I wish I could have captured more of what this remarkable place was like. We hope to plan a trip specifically for exploring the Redwoods.
Now I know that is a route, not a destination. But what I mean is – TAKE IT! Yes, it's full of switchbacks & it was tough & slow to navigate at times, but there are all sorts of places like this to stop & take in the view of the coast.
For a good portion of our journey, this was my view. It sure made it hard to stay motivated to work on the book when all I wanted to do was stare at the Pacific. I don't get to see it nearly as much as I did when I was growing up & I miss it all the time. So I wanted to take in as much of it as I could.
This really is the best route if you want to see the beautiful California coast & you have an extra day or two.
This really is iconic California, right?! It was more hectic than I remember it being when I was last there 20 years ago. We drove across the bridge, saw Alcatraz out the window & before we knew it, we were in downtown…..IN A 25′ RV. I actually don't recommend doing this part of the trip in an RV. The streets are quite narrow so with our wide mirrors, we didn't really fit when there were other large vehicles right next to us. It was scary at times & I was wishing we were in a regular vehicle. But I was so happy the kids got to see this city that is synonymous with California. You really must visit San Francisco at least once in your life.
The Disneyland Resort is one of the most popular family vacation destinations and for good reason! Your kids will love meeting their favorite Disney characters while being immersed in the magic of the parks. The variety of rides and great entertainment means there's something for everyone in your family, no matter your age! A Disneyland vacation is sure to be a trip your kids won't forget.
If your family prefers a beach vacation, San Diego is the perfect spot for you. The weather is amazing all year long and there are more than 15 beaches in the city alone. Your kids will love that SeaWorld and the San Diego Zoo are nearby, too.
Huntington Beach is another wonderful spot for families looking for those great beach vibes. The best part about Huntington Beach is that it's close to Anaheim. That means your family can spend time soaking up the sun along with some Disney magic! Huntington Beach is a vacation destination that kids of all ages will love.
Huntinton Beach was the closest beach to where I grew up, so it's where I spent a good portion of my days. While I was at my class, the family went & explored all the great sights there in my home. It was nice that they got to see all of that. I wish I could have been with them, however, my class was an opportunity I am so grateful I had the chance to experience. It is definitely paying off when it comes to the business.
If your kids are older, Los Angeles may be the best spot for your next vacation. Universal Studios Hollywood is the top attraction here, especially since the Wizarding World of Harry Potter opened in April. Universal Studios isn't the only gem of Los Angeles – you can view the Hollywood Walk of Fame or Wax Museum, along with catching a game at the Dodger Stadium or wandering the Santa Monica Pier. Los Angeles is the perfect destination for families who want a taste of everything!
There you have it – all our favorite places you DO NOT want to miss! I hope this California Travel Guide helps you plan an awesome vacation! Take it from someone that grew up in California, these are where it's at!
You can grab the best deals by booking with Get Away Today because they specialize in family travel. They not only have the best prices, but travel experts to help you plan too. If you do book a Southern California package, make sure to use my EXCLUSIVE promo code KLEINWORTH to save an additional $10 off!
You had a blast! I've been to the LA area a few times but so want to see the San Fran area!
I will need to add glass beach to my list!!
we hope to do an rv trip this summer around the national parks in the midwest. we'll see! i was wondering how you made out in san francsico when i saw the bridge in the link…glad to know you made it ok, but yes, i'd think that would be a little difficult in an rv!


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Facebook Research Awards
From time to time we invite academics to propose research in specific areas that align to our mission of making the world more open and connected.
Invitations typically address specific research challenges that we have identified are important in our mission of making the world more open and connected; these vary in nature and may solicit proposals from individual researchers addressing a well-defined problem or may require multiple university departments to collaborate with a diverse set of skills to solve a more complex multi-disciplinary challenge.
Calls for proposals align to specific areas of research. They offer insight to the academic community on topical research questions of interest to Facebook, where academic insight is key.
Specific details on timing and criteria will apply to each call.
Global Literacy & Accessibility Challenge request for proposals
Facebook is pleased to invite the academic community to respond to this call for research proposals to better understand and address global literacy and accessibility issues. Grant awardees will be expected to contribute to the field of literacy and accessibility through qualitative or quantitative research.
Speech & Audio Technology for Voice Interaction and Video Understanding
Facebook is pleased to invite the academic community to respond to this call for research proposals for speech & audio technology that advances the state-of-the-art in human-computer interaction, human-human interaction, and video content understanding.
Low Resource Neural Machine Translation request for proposals
Facebook is pleased to invite the academic community to respond to this call for research proposals on low-resource Neural Machine Translation. Applicants for the grants will be expected to contribute to the field of low-resource NMT through research into novel, strongly performing models under low-resource training conditions and/or comparable corpora mining techniques for low-resource language pairs.
Secure the Internet Grants request for proposals
Facebook is pleased to invite submissions for Secure the Internet Grant proposals from university researchers and faculty, non-profit organizations, and NGOs for applied research proposals to improve the security, privacy, and safety of internet users.
Caffe2 research award competition request for proposals
Caffe2 is a deep learning framework designed to provide scalability, modularity, flexibility, and speed to projects across many areas including…
Communications and Networking request for proposals
Facebook is pleased to invite university faculty to respond to this call for research proposals on computer communications and networking;…
Hardware and Software Systems request for proposals
Facebook is pleased to invite university faculty to respond to this call for research proposals on hardware and software systems;…
ParlAI request for proposals
Facebook is pleased to invite university teams to respond to this call for research proposals on chatbots and dialogue systems…
Moreinfo: https://research.fb.com/programs/research-awards


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Microsoft Scoring Points in Motorola Lawsuit
Microsoft let it be known today that it is gaining ground in its lawsuit against Motorola over alleged patent infringements associated with the Android mobile operating system.
Microsoft's attorneys claim that Motorola has infringed intellectual property in nine patents granted to Microsoft. Motorola, which also is a partner with Microsoft on Windows Mobile, got slapped with a lawsuit regarding the alleged Android patent infringements in October, and Motorola has promised to fight back. The lawsuit was filed in both the U.S. District Court for Western Washington, as well as at the U.S. International Trade Commission (ITC).
The case is proceeding in both venues. However, in mid-May, Administrative Law Judge Theodore R. Essex, acting on behalf of the ITC filing following a so-called Markman hearing, ruled on the meaning of terms used in the nine patents. The judge ruled in favor of Microsoft's interpretation of those terms 17 times vs. five times in favor of Motorola's interpretation, according to the publicly released claim construction order (PDF).
The arguments over the terms in the patents involve interpreting the meaning of various phrases. For example, the judge ruled on the meaning of "short filename" and "long filename for the file," which apparently refer to Microsoft's File Allocation Table technology and associated patents.
The order goes through each patent systematically in a way that's tedious to relate. However, blogger Florian Mueller, who describes himself as an "intellectual property activist," provides a blow-by-blow scorecard here. Mueller has also been busy creating an infographic that tracks Android-based lawsuits overall.
According to a Microsoft spokesperson, the next step in this case will be a full ITC trial in about six months' time. The spokesperson said that the ITC organization is part of this case because Motorola imports technologies created abroad into the United States, and the ITC has the authority to file an injunction to block those imports. The Washington state district court proceeding is a separate and concurrent matter, handling such aspects as rewards for damages.
The Microsoft spokesperson had no information to share about the progress of the district court proceedings. Still, the administrative law judge's confirmatory interpretations of Microsoft's patents appear to bode ill for hardware device makers that use the Android mobile OS. Another device maker and Microsoft partner, HTC, settled with Microsoft rather than go to court, unlike Motorola.
Android Juggernaut
Android-based devices have been far outselling nascent Windows Phone 7 devices. In addition, Android and Apple iOS have maintained strong developer interest. (See this June Redmond article for a comparison of the three mobile OSes.) Possibly, Microsoft's approach of suing its hardware partners is designed to slow Android's forward momentum thus far.
It's rumored that Motorola may be considering creating its own mobile OS, according to a March PCWorld story. If so, such a move might help Motorola avoid paying Microsoft future royalties should it lose this current legal dispute.
Google, which bought, developed and shepherded the Linux-based Android operating system, has allowed any hardware device maker to use the mobile OS without royalty costs. However, Google doesn't assure indemnity on any intellectual property associated with Android.
Device makers aren't totally without help from Google. According to Law Technology News, Google hired the law firm of Quinn Emanuel Urquhart & Sullivan to provide a legal assistance in such patent disputes.


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Tomás Patricio Charles (born 12 June 1985) is a retired Argentine footballer.

External links
 Profile at BDFA

1985 births
Living people
Argentine footballers
Argentine expatriate footballers
Club Atlético Independiente footballers
Racing Club de Montevideo players
Nyíregyháza Spartacus FC players
C.F. Mérida footballers
La Piedad footballers
Instituto footballers
Unión La Calera footballers
Deportes Iquique footballers
Venados F.C. players
Cafetaleros de Chiapas footballers
Club Almagro players
Boca Unidos footballers
Deportes Temuco footballers
Argentino de Quilmes players
Chilean Primera División players
Uruguayan Primera División players
Ascenso MX players
Primera Nacional players
Primera B Metropolitana players
Argentine expatriate sportspeople in Chile
Expatriate footballers in Chile
Argentine expatriate sportspeople in Mexico
Expatriate footballers in Mexico
Argentine expatriate sportspeople in Uruguay
Expatriate footballers in Uruguay
Argentine expatriate sportspeople in Hungary
Expatriate footballers in Hungary
Association football defenders
Footballers from Buenos Aires

redpajama_set_name: RedPajamaWikipedia


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Al-Tasamoh FC  is a Saudi Arabian football (soccer) team in Al Qunfudhah playing at the Saudi Fourth Division.

Current squad

As of Saudi Third Division:

References

Football clubs in Saudi Arabia
Football clubs in Al Qunfudhah


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Full Episode The Arts,Culture & History,Sports
Wisconsin Life #513: "Heart & Soul"
Wisconsin Life host Angela Fitzgerald heads to the Oneida Nation to explore the rhythm and sounds at the "Music from our Culture" camp. The camp, hosted by the Oneida Nation Arts Program and Community Education Center, gives children the opportunity to learn about tribal and hymnal music heard in their community. Fitzgerald talks with "Music from our Culture" Artistic Director Niko Lee Kal^na Daniels and Board Member Yuntle'kala·ù McLester to learn more about the importance of the camp to the Oneida community.
Fitzgerald also introduces us to extraordinary people from around the state including Mark Fischer, a Germantown artist fusing his heritage into his art. Fischer learned to weld from his father, and was instilled with pride in his Oneida Nation ancestry by his mother. He combines the two into his Native American copper art sculptures. Each statue tells a story, fulfilling Mark's role as educator and artist in the Turtle Clan.
We then visit the City of Durand which is the home to Mark Healey, the bass player of Joey Molland's Badfinger. Healy, a Madison native, grew up playing in the capital city before eventually moving to Los Angeles to pursue a career in music. It was during his time in Los Angeles that Healy got the opportunity to audition for the famous band Badfinger. Healy has been playing with the band for the past 30 years.
Next, we meet Tim DeByl, coach and owner of the Madison Radicals Ultimate Frisbee team. Ultimate Frisbee has risen from a mellow pastime of the 1970's to a legitimate professional sport. Thanks to DeByl, Madison has become the home of one of Ultimate Frisbee's most successful teams.
Finally we travel to Milwaukee to meet Mary Backus and her unique women's music group, the Ukuladies. Backus, a retired music teacher, formed a different kind of music group for women who love to play the ukulele. The group frequently performs at assisted living centers and other events around Milwaukee and even performed at the 2016 Summerfest in Milwaukee.
CLEE252018-01-19T17:53:34-06:00
Remembering The Sheboygan Armory: A Hub For Concerts, Basketball & Community
Youth Group Drumline Helps Kids Find Their Own Beat
Wisconsin Life #508: " Sweet Connections"
Wisconsin Life #507: " Taking Shape"
More Stories from Full Episode
Wisconsin Life # 911: Milton House Museum
Wisconsin Life # 910: Farm Wisconsin Discovery Center
Wisconsin Life # 909: Pine View Wildlife Rehabilitation & Education Center
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Why Beacon Hill resents ballot activists
Initiative petitions exemplify democracy at its finest. But they infringe on the politicians' monopoly.
By Jeff Jacoby Globe Columnist,Updated October 17, 2021, 3:00 a.m.
Donna Kelly-Williams, president of the Massachusetts Nurses Association, which in 2018 backed a ballot initiative that called for minimum levels of nurse staffing statewide. The initiative was defeated.Pat Greenhouse
This is signature-collecting season in Massachusetts, the time of year when activists working to get a proposed law on the state ballot fan out to busy intersections, town dumps, and farmers' markets, bearing initiative petitions for voters to sign.
Most passersby decline to help out — many don't even slow down long enough to find out what the proposed law would do. Perhaps they would be less aloof if they considered just how much effort it takes for private citizens to actually get a measure onto the ballot.
To begin with, they have to live in a state in which grassroots ballot initiatives are permitted — in half the states, such forms of direct democracy don't exist. Massachusetts, happily, is among the states that do allow citizen lawmaking. This year 30 proposed ballot measures, involving issues as varied as liquor licenses, fireworks, and whale-safe fishing gear, were submitted to Attorney General Maura Healey for approval. Of those 30, the AG's office certified only 17 as meeting the requirements outlined in the Massachusetts constitution, clearing them to advance to the next part of the process.
For a proposed law to move forward, its supporters must collect signatures from 80,239 registered voters, no more than a quarter of whom may live in the same county. Those signatures then have to be submitted to the registrars in individual city and town halls for certification by Nov. 17.
Then come six months of waiting, during which the Legislature has the option of enacting the proposed law directly. If it hasn't done so by May 4, 2022, supporters will need to go through a second round of signature-collecting. They'll have until July 6 to get an additional 13,374 registered voters to sign petitions. If they get that far, the measure goes to the fall ballot and the law's proponents can begin their election campaign in earnest.
But that only scratches the surface of what ballot activists must deal with.
Besides confirming that people signing their petitions are registered Massachusetts voters, the petitioners must have a separate sheet for each city or town in their area: If a voter registered in Cambridge or Quincy signs a petition sheet for Boston, that signature is thrown out. The petitioners must also ensure that people sign their full legal names and list their home addresses exactly as they appear on the voter rolls. No nicknames, no P.O. box numbers. Otherwise, the signatures are tossed.
In printing and handling the petition sheets, the signature-collectors must go to extraordinary lengths to make sure that not a single stray mark appears anywhere on either the front or back — no note, no underline, no check mark, no doodle, no highlighting, no arrow, no coffee stain. Under Massachusetts law, there may be no "extraneous markings" on a ballot petition. One errant smudge, one squiggle, and every signature on the sheet is thrown out. It's an outrageous impediment, which is just how Beacon Hill wants it. In 1999, the Supreme Judicial Court upheld the voiding of more than 3,500 signatures — enough to disqualify a ballot campaign — because of some insignificant jottings on the petition sheets.
Facing so many strictures and hurdles, initiative petition campaigners know that a significant chunk of the signatures they submit are bound to be invalidated. So they have no choice but to collect far more than the number legally required — at least 50 percent more, according to Chip Ford, the executive director of Citizens for Limited Taxation and a veteran of many Massachusetts ballot campaigns. CLT, the grassroots activist group that put Proposition 2½ on the ballot in 1980, is currently backing an initiative to block an increase in gasoline taxes. Ford estimates that roughly 120,000 "raw" signatures will have to be turned in by Nov. 17 in order to be sure that 80,239 of them will pass muster.
Legislators and other political insiders tend to resent initiative petitions as an infringement on their governing monopoly, which explains why citizens trying to get a measure on the ballot face so many obstacles. If history is any guide, most of the 17 initiative petitions that the attorney general cleared to circulate will not succeed in garnering the signatures needed to move forward. Over the past 20 years, no more than four citizen-sponsored initiatives have made it to the ballot in any election. The vast majority of would-be ballot measures are derailed before they ever get to the voters. Incredibly, in the 102 years since the right of initiative and referendum was added to the Massachusetts Constitution, only 84 citizen petitions were ultimately brought to a vote of the people — and only 38 were enacted.
What is true in Massachusetts is true nationwide. Between 2010 and 2020, according to Victoria Antram, a researcher for the nonpartisan political research firm Ballotpedia, a total of 4,685 ballot initiatives were filed in the states that permit laws to be passed at the polls. Only 340 of them survived the procedural gauntlet and made the ballot. And of those, just 178 were ultimately approved by voters.
By contrast, tens of thousands of laws are enacted in the state legislatures every single term. In the 2013-2014 political cycle, for example, Congressional Quarterly tallied 45,564 bills passed in the 50 states (and the District of Columbia) — an average of 447 bills approved per state per year. The Washington Post, crunching the numbers separately, reached an almost identical result.
Here in Massachusetts, the Legislature enacted 539 laws in the biennial legislative session that ended last year. And it did so, for the most part, without facing so much as a shred of the public scrutiny that initiative petitions are subjected to. Indeed, Beacon Hill is notorious for its lack of transparency. The fate of virtually all bills is decided behind closed doors by a few powerful members, with no public input or open debate. "Don't confuse what goes on in this building with democracy," a seasoned State House lobbyist told a reporter in a moment of undisguised exasperation.
Politicians and political pundits often deride ballot initiatives as confusing for voters, lacking in nuance, or too easily manipulated by special interests and advertising. The odds against any initiative petition's success are steep, yet lawmakers frequently propose new restrictions and requirements designed to make them even steeper.
But if political insiders begrudge the initiative and referendum process, the rest of us have every reason to embrace it. Ballot campaigns are often the only outlet available to bypass lawmakers who turn a deaf ear to the public. It isn't easy to get a law enacted by popular vote. Those that succeed have almost invariably been subjected to more careful vetting, more thorough debate, and more transparent coverage than 90 percent of the bills approved in the Legislature.
When you see activists collecting signatures for a ballot initiative, you're seeing citizen lawmaking at its finest. Want to stick it to Beacon Hill? Stop and sign the petition.
Jeff Jacoby can be reached at jeff.jacoby@globe.com. Follow him on Twitter @jeff_jacoby. To subscribe to Arguable, his weekly newsletter, visit bitly.com/Arguable.
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Q: SLURM node assignment order not always following Weight setting We have a small cluster of 25 nodes running Slurm, of which the nodes can fall into a number of categories, as all the nodes are not the same. We have bigger/powerful nodes, and small/weak nodes.
All these nodes are, for the most part, basically in one partition, and we use the various job request settings for specifying which node(s) a job gets.
We also use the Weight setting on all the nodes, so that small jobs are to go to the small/weak nodes first, and not take space on the bigger nodes.
And here is the problem: If the nodes are on, (we use Slurm's power saving feature to switch unused nodes off) it works as expected. A small job goes to a small node.
However, if the nodes are off, (there are no nodes that can take it currently on) the node assigned seems to ignore the Weight setting, and seems to go where-ever. A small job may end up assigned to and switching on a big node. It seems to show the most when some nodes are on, but in use, and other nodes are off.
Can someone shed some light on this?

redpajama_set_name: RedPajamaStackExchange


Been mentioned in passing a couple of times at local shoots last few days and meant to ask pickers on shoot tody as quite clued up.
Does ur dogs have to be restrained? Have had a look at the useal places basc/sga and googe but nothing really coming up.
Some were saying dogs should be in a box/crate r even in the back under a canopy but it has to be sub divided?
If you have a canopy there's no requirement to have them caged.
Edited to add: I assume you mean an enclosed canopy like a Truckman etc.
I think common sense says don't put loose dogs in an open pick up bed. Just asking for trouble. Like letting your dog hang out of the window. A friend visting Tenerif took a taxi and the driver only had a stub for a left arm half way up his bicep. He asked what happened and he said he had his arm out of the window holding the roof on, when a truck went by. Dgs hanging out of truck beds and windows are a menace. I do not know of any law which dictates you have to have them restrained inside the cab or canopy but again for the sake of the dogs well being it is good to have them in a dog box.
All passengers. Irrespective of type of species has to be belted or restrained .
I'm 28yrs out of date so just did a quick bit of research. the Highways Act covers it and all pets must be restrained when in a vehicle to prevent it being thrown forward in the event of a crash or heavy braking. A restraining belt/collar or a dog box or dog guard. I would believe that dogs in a canopy in the rear of a pick up truck with a gate on the canopy would be considerd restrained as they canot be thrown forward into the cab area. Top prize is a £5000 fine.
That can't apply to a canopy on a pickup. It is in a separate compartment from the driver and is restrained from going through the windscreen by the window on the front of the canopy and the rear screen on the pickup.
Sorry i should of made it clearer my dogs are in the back under the canopy so totaly enclosed but do have the whole back bunk of pick up.
Wot a couple were saying was they should still be inside some sort of dog box, seemingly a company is making dividers to make divide the back up and that would be legal.
I can vaguley remember some sort of law change (tpical scootish NUMPTY party thing) but haven't managed to find anythig online mentioning.it yet.
I live in Scotland and have had an l200 with canopy for years. The dogs are restrained by virtue of being in the rear canopy. When I go out on the Estate and use public roads we use their vehicles and again all dogs are in the canopy area. Not once has there been any discussion about the legality and given this is one of the biggest sporting estates in the UK it would have. So my conclusion unless proven wrong is there is nothing illegal about it the dogs are restrained in the rear loading area of a commercial vehicle.
As to practicality my four labs are in a newly purchased dog box. That way they are separated from my shooting kit, dead game etc but that is my choice. Dog box or not they are trained not to even put their paws on the tailgate unless called out individually.
Been a good few years since i picked up there tho.
I would just throw them in the back, they will still have less room to fly around than most livestock trailers.
Must be restrained in the back of vehicle to stop them running into road in case of a accident.
our dogs are i a dog hammock on back seat of motor.
So in that case they should be in a box??
Many moons ago back in the early 70s I used to occasionally shoot with Geoff Turner who had a sporting hotel in the little village of Glyn Ceiriog. One estate he used to arrange shooting at was Aqualate Hall. We stood in the car parking area one morning and up drove a hard top MGB. The lady got out and opened the back door and four or five labradors jumped out .
How they managed to all fit in, heaven knows, but I have rarely seen a better trained team of dogs ever. She let them have a quick scoot round and then on one command they all sat in line.
At the end of the day, she opened the back of the MGB and they all jumped in and she drove off. There is no way those dogs could be flung forward they were all so tightly packed.
A picker up I know had a gate system over draws under a canopy in his pickup, he was stopped on the A66 trans pennine route by a traffic cop. He was told his set up was illegal. He's now got a separate box inside the canopy, he's not someone to spend brass so I suspect his story is true.
I also know an ex traffic cop that picks up & he also has a box in his pickup.
I have a cab box in my pickup, the first thing that's coming off in a serious impact is the canopy, it'll either shatter or the brackets will snap. If my dogs do survive an impact I don't want them running round the road.
i suspect it's another vague law, a bit like what speed limit you're supposed to obey in a pickup.
Even on pheasants i usually tow a mates dog trailer and have 9-10 dogs between the pair of us.
There's no law about dogs not being able to get out in case of an accident. If that was the case, should we board our windows up in case one breaks? The law says they shouldn't be able to distract you or injure you in case of an accident.
A dog in the canopy of a pickup can't do any of those things.
Any i've seen are quite good set ups with individual cages/boxs for the dogs.
My mates alwys eyeing up ex polis dog handlers vans on ebay as look the business they waythere kitted out.


Dural venous sinuses are venous blood reservoirs contained between the two layers of the dura mater. The absence of lymphatic drainage in the brain places the venous outflow system on a pedestal of prime importance. Following a prologue to dural venous sinuses, this article focuses on arachnoid granulations, tributaries and the drainage pattern of the venous sinuses.
The dura mater (Latin: tough mother) with its varied reflections segregates the brain into structural compartments. There are two layers of the dura mater, the inner or meningeal layer and the outer, i.e., periosteal or endosteal layer.
These layers snugly fit each other in almost all locations but for certain avenues, where they split to accommodate the venous channels. These reservoirs are the dural venous sinuses, which convene blood from the meninges, calvarium and the brain to finally seep into the jugular veins at the base of the skull.
Defying the norm, the venous drainage of the brain does not follow the arteries. The brain also does not possess a lymphatic system.
Distantly akin to the lymphatics, the brain has Virchow-Robin spaces, the perivascular pia mater lined fluid cisterns, which convey fluid from neuronal cell bodies to the cervical lymph nodes. These are, however, extremely diminutive, and the brain relies on the venous system for CSF absorption and clearance of neuronal, chemical and metabolic waste in a profound manner.
Drainage expanse Being the predominant system, its enclave is inclusive of the majority of brain parenchyma. Through the torcular confluence of Herophili, it ultimately empties into the jugular vein en route the transverse and sigmoid sinuses. This group drains the basal and medial surfaces of the brain and the orbits. This system opens into the sigmoid sinus and jugular vein.
The DVS have endothelium-lined walls composed of the dura mater. They are valveless and lack the usual organization of vessel wall into tunica intima, media, and albuginea.
Most of the DVS are triangular in shape with the base turned upwards. They are traversed by synechiae and have longitudinal ridges known as chordae Willisii along the luminal surface. The chordae have a potential role in the regulation of laminar flow and preclusion of venous reflux into cortical veins.
It is situated along the superior border of falx cerebri, from foramen caecum of the crista galli en route to the inner surface of the frontal sagittal face of the parietal and occipital bones to the confluence of the sinuses.
Arachnoid granulations are most numerous along the sagittal sinus. They facilitate CSF drainage and absorption.
The vein of Trolard, also known as the superior anastomotic vein, connects the superficial middle cerebral vein to the SSS.
SSS drains the anterior corpus callosum, medial hemispheres, and the cingulated gyrus. Seldom, drainage of the nasal fields via connecting veins makes nasal and facial infections potential provenience for SSS thrombosis.
Also known as the longitudinal inferior sinus, it ensues at the junction of the anterior and middle third of the falx cerebri and extends along the entire length of the lower border.
Angiographic location of the inferior sagittal sinus marks the anterior midline of the brain. Early filling or displacement of the same has localizing value.
The inferior sagittal sinus drains the medial and deep aspects of the cerebral hemispheres.
Also known as lateral sinuses, these paired structures lie in the confines of the tentorium cerebelli and extend from the internal occipital protuberance to the base of the petrous temporal bone.
Usually, the superior sagittal sinus continues as the dominant larger right transverse sinus, and the inferior sagittal sinus flows into the left transverse sinus, but the anatomical variation is rather the norm.
The vein of Labbe, or the inferior anastomotic vein, connects the superficial middle cerebral vein to the transverse sinus.
It drains the temporal lobe, posterior cingulate gyrus, and the corpus callosum.
Named after their characteristic "S-shaped" turn as they traverse to the jugular veins, these paired sinuses display immense anatomic variation in formation, course, and dominance. They represent extensions of the transverse sinus. The transition to the internal jugular vein occurs at the foramen jugulare.
The junction of the sigmoid sinus and transverse sinus is marked externally by asterion, which forms an important surgical landmark for posterior fossa surgeries.
It drains the posterior cranial fossa and posterior aspect of the calvarium and serves as the penultimate sinus before the jugular veins.
The anterior and posterior intercavernous sinuses are transverse venous channels communicating the cavernous sinuses across the diaphragm sella.
The inferior sagittal sinus joins the great cerebral vein of Galen to form the sinus rectus, also known as the straight sinus. At the internal occipital protuberance, it continues into the left transverse sinus.
Enclosed in the leaflets of the falx cerebelli, this is the smallest of all sinuses. It is commonly appreciated in pediatrics. It communicates with the internal vertebral plexus, sigmoid sinus, and the confluence.
Lodged in the petrous temporal bone's groove, it travels from the cavernous sinus to each side of the transverse sinus.
Also known as torcular Herophili in reverence of Herophilos, the Greek anatomist, the confluence is the depot for communication between the four major sinuses, namely the superior sagittal sinus, occipital sinus and the corresponding transverse sinuses.
These are arachnoid membrane projections into the DVS, which facilitate CSF drainage from the subarachnoid spaces into the venous system. Evidence endorses the role of arachnoid granulations as one-way valves to prevent reverse reflux from venous lakes to the subarachnoid space.
The most frequent location is along the lateral venous lacunae of the superior sagittal sinus, followed by transverse sinus. There are three consistent venous lacunae on each side of the SSS: the frontal, the parietal and the occipital lacunae.
The arachnoid granulations comprise arachnoid projections at the base with collagenous stroma, trabeculae, and interlaced conduits. The collagenous core is surmounted by an apical cap of arachnoid cells. The cap cells of the arachnoid membrane are the harbingers of meningiomas.
They simulate filling defects in the sinuses and may erroneously lead to an amateurish diagnosis of sinus thrombosis. The distinction lies in their classic location near draining tributaries and their round, well-defined morphological appearance.
Miniature-sized granulations are termed as villi.
Named after the Italian anatomist Antonio Pacchioni, calcified granulations are termed as Pacchionian bodies. Occasionally, arachnoid granulations are entitled the eponym Pacchioni's granulations.
Granular fovea are impressions of arachnoid granulations on the undersurface of the overlying bone.
The meningeal veins intermingle to form a plexus in the endosteal layer of the dura and in the potential space between it and the periosteum of the inner table of the calvarium. They peregrinate between the DVS internally and the pterygoid plexus after exiting the skull. Along with the diploic veins, they amalgamate into the lateral venous lacunae in the DVS.
These veins are frequently seen in the parasagittal aspect of the SSS and around the sigmoid sinus. They are situated at the interface between the extracranial veins, DVS, meningeal veins and the diploic veins.
Veins in the cribriform region Connecting the SSS and veins of nasal mucosa.
Situated in the diploe, these endothelial-lined, large, thin-walled, venous lakes connect the internal meningeal veins and DVS with extracranial veins. They are concentrated in the cancellous bones. The frontal vein communicating between the supraorbital vein and the SSS, and the anterior temporal diploic vein tending to the sphenoparietal sinus are few prototypes.
Superior sagittal sinus Parietal emissary veins, superior cerebral veins, scalp veins, cavernous sinus through superior anastomotic veins, meningeal veins, veins of the frontal sinus, diploic veins.
Inferior sagittal sinus Veins draining the limbic lobe (cingulated gyrus), medial frontoparietal lobe and genu of the corpus callosum, deep cerebral veins.
Straight sinus Superior cerebellar veins, few tributaries from falx cerebri.
Superior petrosal sinus Cerebellar, inferior cerebral and tympanic veins.
The DVS system is a gigantic, organized plexus of venous cisterns meant to serve proficient venous outflow from the brain to the internal jugular veins.
Venous sinus thrombosis occurs as a result of systemic diseases or various infections.
Cavernous sinus can get infected from various routes and foci resulting in thrombosis. Infection from the triangle of face that is formed by two corners of mouth and bridge of the nose can spread to cavernous sinus and infect it.
Cavernous Sinus Syndrome– this syndrome involves the cavernous sinus along with cranial nerves, internal carotid artery, and sympathetic plexus because of their association giving rise to a set of clinical manifestations.
Carotid-cavernous Fistula– it is abnormal communication between cavernous sinus and carotid arteries and its branches.
Tolosa-Hunt Syndrome– This infers to ophthalmoplegia (weakness of eye muscles) caused by nonspecific infection of the cavernous sinus and superior orbital fissure.
The dural venous sinuses are enclosed in the two layers of the dura mater. They drain the brain parenchyma, communicate with extracranial veins and ultimately merge to form the internal jugular veins.
Arachnoid granulations are projections of the arachnoid penetrating the dural envelope of the dural venous sinuses with the purpose to facilitate CSF drainage from the subarachnoid spaces into the venous lacunae. Their morphological advantage as one-way valves helps in preventing reflux.
The tributaries communicate with cerebral veins, extracranial veins, and the dural venous sinuses. There are meningeal veins, diploic veins, emissary veins, bridging veins and intermediate anastomotic channels. Anatomical variation is common.
1. Which sinus does not drain into the torcular Herophili?
They are present in the superior sagittal sinus.
They regulate CSF absorption in the dural venous sinuses.
They are projections of arachnoid mater into the venous sinuses.
They are pathological granulations of the arachnoid mater, seen in granulomatous diseases.
Upton ML, Weller RO. The morphology of cerebrospinal fluid drainage pathways in human arachnoid granulations. J Neurosurg. 1985 Dec; 63(6):867-75.
Curé JK, Van Tassel P, Smith MT. Normal and variant anatomy of the dural venous sinuses. Semin Ultrasound CT MR. 1994 Dec; 15(6):499-519.
Hutchinson E.C. Review on Cerebral Dural Sinuses and their Tributaries: by J. Browder and H. A. Kaplan. J Neurol Neurosurg Psychiatry. 1977 Aug; 40(8): 831.
Anand's Human Anatomy for Dental Students.


Most people have things that are precious to them or that evoke memories. Other people have collections and need somewhere to house them or show them off, be they coins, stones or toy cars.
I believe that your display should be just as attractive as the items inside. It should draw peoples attention to it, and it needs to look good in it's setting.
I now offer a bespoke designer maker service for display cases and collection boxes.
The images below are of two recent commissions.
The small glass case holds an England Cap. It is made from Oak, lined in red suede and has museum quality glass with UV protection to prevent fading. This was a unique shape for this item, and shows the benefit of have something tailor made to your requirements.
The collection box is made from Paduak and Sycamore with veneered sides and rear. The doors are book matched Fir burl. It has twelve drawers, ten at 30mm high and two at 60mm high. Each drawer is lined in suede and comes with adjustable dividers. There is a removable glass display top for showing off those special items in the collection. All in, the box is about 600mm x 600mm x 450mm deep.


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Legal Analyst, Global Trade Compliance
Google San Francisco, CA Sat, 13 Jul 2019 02:18:06 GMT - 7 days ago
Note: By applying to this position your application is automatically submitted to the following locations: Mountain View, CA, USA; San Francisco, CA, USA
Bachelor's degree or equivalent practical experience.
6 months of experience in legal, policy, government, or economics.
Experience with G Suite applications (Gmail, Docs, Sheets, etc.) or similar collaboration software.
Authorization to work in the United States.
Experience in deemed-export licensing.
Experience using data to identify trends and potential risks.
Ability to contribute in a fast-paced, changing work environment with excellent attention to detail.
Ability to manage numerous projects simultaneously under deadlines.
Ability to work on a broad range of legal matters.
Ability to interact professionally with all levels of internal and external stakeholders.
Google's legal department is at the center of an information law revolution, and you're at its core. As a Legal Assistant, you are a driving force behind the success of your Legal team, ready to roll up your sleeves to create and improve processes, maintain records, conduct legal research and coordinate communications across the team. As you closely support your team, you may find yourself working with multiple groups within the Legal Department, internal clients across Google, and external parties. You're an independent thinker who isn't afraid to ask questions, and you're organized in a way that never overlooks the details.
The Global Trade Compliance team is responsible for analyzing and interpreting legal regulations and statutes, advising clients, and submitting government filings. As a Legal Analyst on Global Trade Compliance, Export team, you will prepare materials for the filing of deemed-export license applications, engage and coordinate with internal groups, communicate with recruiters and candidates to gather information, and drive the management of filed and issued licenses.
In this role, you will comfortable troubleshooting issues, documenting work, and moving issues and resolutions forward at a steady pace. Additionally, you will contribute an ability to manage multiple tasks efficiently and work productively in a fast-paced, team-oriented environment, demonstrating excellent judgment.
20th century laws don't always solve 21st century problems, and Google Legal crafts innovative approaches for handling some of the toughest legal challenges of the information age. Whether you're a patent attorney, an intellectual property expert or an engineer headed to law school, Google Legal lets you take on unanswered legal quandaries and create new precedents. Our innovative services raise challenging questions that demand creative and practical answers. We provide those answers by working at the crossroads of the law and new technology, helping Google build innovative and important products for users around the world.
Manage deemed export license applications and existing licenses by assisting with applications, letters of assurance, and tracking.
Review export control questionnaires from employees and visitors and whitelisting individuals to access restricted projects and/or sites.
Help with general case management administration and organization of key documents.
Assist with collection of relevant materials to file license applications and coordinate with external legal counsel.
Analyze data and identifying potential risk areas.
At Google, we don't just accept difference—we celebrate it, we support it, and we thrive on it for the benefit of our employees, our products and our community. Google is proud to be an equal opportunity workplace and is an affirmative action employer. We are committed to equal employment opportunity regardless of race, color, ancestry, religion, sex, national origin, sexual orientation, age, citizenship, marital status, disability, gender identity or Veteran status. We also consider qualified applicants regardless of criminal histories, consistent with legal requirements. See also Google's EEO Policy and EEO is the Law. If you have a disability or special need that requires accommodation, please let us know by completing this form.
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Q: Display wpf window on second monitor using Prism I am developing a wpf application using Prism that:
opens the application on monitor 1. Should launch a full screen window on monitor 2.
This window will be used to draw graphics.
How do I create 2 windows using Prism? Should I show this using a dialog or is there a better way a window on second monitor and draw grpahics?

A: You have to use System.Windows.Forms to use "Screen" which will provide you connected screens/monitors with resolution, Primary Display and other info.
You have to create another Window/Shell for secondary display along with a separate region manager to manage secondary display's region and navigation.. Refer below method for creation of secondary window and region manager
InitializeShell(Window shell) method

Now You also have to create a separate Region Manager and store the instance in some global kind of variable to manage navigation on secondary display.
protected override void InitializeShell(Window shell)
   base.InitializeShell(shell);
   Current.MainWindow.Show();

   var regionManager = this.Container.Resolve<IRegionManager>();
   var secondRegionManager = regionManager.CreateRegionManager();

   SecondaryWindow secondaryWindow = new SecondaryWindow(secondRegionManager);

   System.Drawing.Rectangle rectangle = secondaryScreen.WorkingArea;
   secondaryWindow.WindowState = System.Windows.WindowState.Normal;
   secondaryWindow.WindowStartupLocation =
   System.Windows.WindowStartupLocation.Manual;
   secondaryWindow.Top = rectangle.Top;
   secondaryWindow.Left = rectangle.Left;

   secondaryWindow.Show();
   secondaryWindow.WindowState = System.Windows.WindowState.Maximized;

   GlobalVariables.SecondaryRegionManager = secondRegionManager;  // storing in global variable


We didn't quite see it coming. Batman: Arkham Origins has knocked GTA V off the top spot in this week's UK chart. Perhaps everyone in the world already owns a copy of Rockstar's car theft simulator.
That's an impressive chart entry for a game that got mixed reviews, with publishers Warner Bros. putting an embargo on reviews until launch day. Clearly, enough people just went out and bought it anyway.
Other new entries include Ubisoft's Rocksmith 2014 Edition at #15 and Activision's mildly offensive Teenage Mutant Ninja Turtles entering at #27 – Matt wasn't a fan.
The rest of the chart remains more or less unchanged from previous weeks, with GTA V falling to #2, above FIFA 14, Skylanders: Swap Force and Pokemon X and Y.
Nintendo's The Legend Of Zelda: The Wind Waker HD falls from #16 to #28, suggesting that people don't know a good thing when they see it, or whilst Zelda has enough pull for fans of the series, the general public are fickle, Link hating bastards.
Curiously Lego The Lord Of The Rings has jumped up the charts from #19 to #8, which might have something to do with it being bundled with the Nintendo 2DS in an Argos deal.
With Assassin's Creed IV and Battlefield 4 both out this week, it looks like there'll be a fight for the top spot in next week's chart.
This week sees the release of a hotly anticipated bat-based sequel that has so far remained hidden in the shadows, muttering quietly in an oddly deep voice.
Eager guitarists might be pleased to see Rocksmith 2014 Edition this week, which lets you plug a real guitar into your console and attempt to play various songs. Muse's Knights of Cydonia is on the track listing, so, that'll be useful if you want to learn how to play that on guitar instead of Muse's better, earlier work.
Wii owners rejoice, as this week sees the release of Wii Party U, which oddly enough Nintendo are charging money for, but it does come with a Wii Remote Plus, which sort of justifies the price tag.
If you like turtles, specifically teenage ones with martial arts skills, then you'll be pleased to know Teenage Mutant Ninja Turtles is also out this week, on Xbox 360, Wii and 3DS. Who doesn't like heroes in a half shell?
Remember when rally driving games were great, back in the '90s? Sega Rally and Colin McRae. Ahh, those were the days. The PS2 even saw some great WRC games from DriveClub developers Evolution Studios. Sadly, WRC 4: World Rally Championship is from a different developer entirely, and whilst reasonably serviceable as a rallying game, it's no Colin McRae. But Xbox 360, PS3, Vita and PC owners can enjoy it this week – hurrah!
Naruto Ultimate Ninja Storm 3: Full Burst is also a game, that some people who own an Xbox 360 or PS3 might buy. Then there's Deus Ex: Human Revolution – Director's Cut, for Xbox 360, PS3 and Wii U owners who want to play a slightly updated version of a two year old game.
Nippon Ichi fans finally get to play with The Guided Fate Paradox on PS3. It came out in Japan back in January, and like most Nippon Ichi games, it's a quirky dungeon crawler. Metacritic gives it a score of 76% – which kind of sounds about right.
On the digital download front, there's zombie island survival simulator How To Survive for Xbox 360, PS3 and PC. If your idea of dream holiday involves being stranded on a zombie infested island, finding shelter, building makeshift weapons and running away from zombie hordes, this could be just your kind of game. It's a bit like State of Decay, which was excellent, so we have high hopes for this one.
Then there are some other titles you really shouldn't care about, such as Just Dance Kids 2014, Brain Training 3D and Beyblade: Evolution. There may have been others we missed. Don't worry about those though. Why would you want to buy those games?
Next week, Assassin's Creed IV: Black Flag brings us pirate themed assassination, EA release a very big first person shooter known as Battlefield 4, whilst wrestling fans will get to play with WWE 2K14. There may be other games too.
Those who have been waiting patiently for a major Wii release will be rejoicing this week – Xenoblade Chronicles is here. Very few bad things have been said about this JRPG, with the likes of Eurogamer dishing out a 9 while NGamer Magazine awarded it their highest score of the year so far – a handsome 93%. Unless Tesco have put the incorrect picture up, it's only £31.97 on their site with the classic red controller. Don't blame us though if they've cocked that up.
Arcana Heart 3 on Xbox 360 and PlayStation 3 is another that comes in a limited edition pack. This is no RPG however – it's a 2D brawler much like Blazblue. Review copies were sent out to the press in good time – most of the magazines reviewed it last month with universal opinion being that it's not too shabby at all.
Super sequel Toy Soldiers: Cold War on Xbox Live Arcade is one to consider downloading. It doesn't quite manage to stand up to the impressive original, mostly because the developers haven't been able to find the right mixture of strategy and action this time round, but word has it the co-op mode is enjoyable and the mini-games are fun.
You know what's coming next, don't you? It's time for a round-up of the seemingly random DS games hitting shelves this week. You've got a combination of Avanquest Software and Easy Interactive to thank (or blame) for Farm Frenzy 3, Mechanic Master 2, Youda Legend: Amsterdam Diamond and Timmy Time.
Then on Wii there's Country Dance from Funbox Media. Believe it or not, it has been developed by the guys that brought us The Conduit. They must be gagging for work.
Next week: Deus Ex: Human Revolution (PS3, 360, PC), Inazuma Eleven (DS), Pac-Man and Galaga: Dimensions (3DS), Rugby World Cup 2011 (PS3, 360), Summer Challenge (PS3, 360, Wii, PC), The Lost Treasures of Alexandria (DS) and Jewel Quest IV (DS).
You don't need me to tell you that Pheasants Forever is a hunting game. And as you may have guessed, it's for Wii. But what a strange name to call a game – if people hunted pheasants forever then there will be none left. I suppose though they couldn't have called it Pheasant Slaughter Sim. If it's any better than Duck Hunt on the NES I will be very surprised, and if review copies have been sent to press I'd be even more so.
If you feel that fruit needs to be punished rather than pheasants, there's Fruit Ninja Kinect on Xbox Live Arcade. It got an 8/10 in 360 Gamer magazine – "It is what it is" they said. A simple game done well, in other words. It's a greatly improved version, or rather a totally new version, of the popular iOS game. If you can wait a while it's also going to be bundled on the same disk as The Gunstringer, which was once due on Xbox Live Arcade but is now a retail release.
As per the usual, there are a couple of seemingly random DS games out this week too. Mystery Tales Part 2 and 7 Wonders: Treasures of Seven, to be precise. We all remember the classic that was the original Mystery Tales, don't we? Yep. 7 Wonders: Treasures of Seven appears to be the sequel to 7 Wonders II but by going by the boxart and product descriptions the differences between the two sound rather minimal.
Next week: Xenoblade Chronicles (Wii), Toy Soldiers: Cold War (XBLA), Arcana Heart 3 (PS3, 360), Country Dance (Wii), Farm Frenzy 3 (DS), Timmy Time (DS) and Youda Legend: Amsterdam Diamond (DS).
If you thought last week was bad for new releases – with just three titles hitting shop shelves – then get a load of this week.
There's just one game out, and that's the largely unknown May's Mysteries: The Secret of Dragonville on DS. The promotional video on YouTube suggests that it has much in common with the Professor Layton series, only from the looks of things the majority of puzzles take the form of those absurdly popular hidden object games.
In the world of downloads there's Insanely Twisted Shadow Planet – the latest instalment of Microsoft's Summer of Arcade promotion. Our Twitter followers have had plenty of good things to say about it, so it was a bit of a surprise when the usually reliable Eurogamer dished out a 6/10. Probably best to download the demo and make up your own mind.
The above may only be exclusive to Xbox 360, but Brink's add-on pack Agents of Change is available on Xbox 360, PSN and Steam. What's more is that it's free for the next two weeks as the developer's way of saying sorry for server issues during the game's launch. It doesn't sound like a bad package – two new maps, five additional abilities, two new weapon attachments and two new outfits. That's as well as a fresh bunch of achievements/trophies to unlock and the chance to get your character up from level 20 to 24. You can read what we thought of Brink here.
Next week: Fruit Ninja Kinect (XBLA), Pheasants Forever (Wii), Mystery Tales Part 2 (DS), 7 Wonders: Treasures of Seven (DS).
Curb your enthusiasm – you can count this week's new releases using both of your thumbs.
Air Conflicts – Secret Wars (out on Xbox 360, PS3 and PC) is compatible with 3D TVs and has online play for up to eight other aviators. There's a bit more information on the publisher's site if you're curious but it's probably best to wait for reviews to appear before taking the plunge.
Then we have Hidden Mysteries: Vampire Secrets on DS, which is the 758th hidden object game to be released on the system this year. These things must be incredibly cheap and simple to create. A few static backgrounds with some sprites scattered around, a bit of simple code running behind the scenes and voila – one new game to shove out. The DS deserves better, frankly.
Next week: Captain America: Super Soldier, Earth Defence Force: Insect Armageddon, Harry Potter and the Deathly Hallows – Part 2, Dream Trigger 3D and Just Dance 2 – Extra Songs.


text:
Home Covid-19 Coronavirus RECAP: Thailand finds 2,174 new Covid-19 confirmed domestic infections in past 24...
RECAP: Thailand finds 2,174 new Covid-19 confirmed domestic infections in past 24 hours, with 15 additional fatalities with underlying health conditions
Tuesday, 27 April 2021, 17:34
Thailand reported 2,174 domestic infections among a total of 2,179 new, confirmed Covid-19 cases with 15 additional deaths in the past 24 hours, CCSA spokesperson Taweesilp Visanuyothin announced this morning, April 27th.
The fatalities were (1) a 47-year-old man from Nakhon Sawan with underlying conditions of hypertension; (2) a 65-year-old man from Nakhon Sawan who had hypertension, hyperlipidemia, chronic liver disease, asthma, and obesity; (3) an 86-year-old woman from Phetchaburi with health conditions of anemia and diabetes; (4) a 71-year-old man from Samut Prakan who had obesity; (5) a 52-year-old woman from Bangkok with underlying conditions of hypertension and diabetes; (6) a 24-year-old man from Saraburi who had pulmonary fibrosis; (7) a 64-year-old man from Chaiyaphom who had liver cancer; (8) an 88-year-old Thai man with underlying health conditions of Alzheimer's, Parkinson's, and chronic obstructive pulmonary disease (COPD); (9) a 37-year-old woman from Bangkok who had Thalassemia and diabetes; (10) a 65-year-old woman from Bangkok with health conditions of heart disease, diabetes, hypertension, and kidney disease; (11) and a 59-year-old man from Bangkok who had hypertension, diabetes, and hyperlipidemia. The other four cases were not given exact details.
Regarding domestic infections, the first group of 993 local infections was discovered in Bangkok. 22 of them were reportedly connected to entertainment venues, 24 were from community markets and villages, 254 were from being in close contact with confirmed infected patients, and the other 693 infections were connected to other risky places.
The second group includes 424 cases that were reported in Bangkok's vicinity. 11 of them were reportedly connected to entertainment venues, 24 were from community markets and villages, 263 were from being close contact with confirmed infected patients, and the other 126 cases were connected to other risky places.
The last group includes 757 domestic infections that were found in other provinces. 15 of them were connected to entertainment venues, 21 were from community markets and villages, 378 were from being close contact with confirmed infected patients, and 343 of them were connected to other risky places. The majority of the group was discovered in Nonthaburi with 149, followed by Samut Prakan with 93, Chonburi with 80, and Chiang Mai with 60.
As of today, 1,958 people fully recovered in the past 24 hours and have been released from field hospitals and quarantine centers. Thailand has now reached a total of 59,687 cases with 33,551 recoveries and a total of 163 deaths since the start of the pandemic. About 40,184 people received their first shot of a Covid-19 vaccination and another 37,182 people received their second shot yesterday, marking a total number of 1,227,032 vaccinated people in Thailand who have received at least one dose of a vaccine.
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The OSHA Training Center (OTC) has announced that they have partnered with four leading safety training companies in Southern California and have launched their new 2013 OSHA training program in that area.
The quality of education demonstrated by our partners exemplifies the high degree of excellence that OSHA Training Center students have come to expect.
The OSHA Training Center (OTC) at Chabot-Las Positas Community College District announced its partnership with four leading safety and health organizations in the Los Angeles area to provide U.S. Department of Labor OSHA courses at locations including Carson, Fullerton, San Bernardino, and Anaheim in California.
This expansion brings vital OSHA training courses geographically closer to students in Southern California and allows them to more easily participate in Certified Safety and Health Official (CSHO) Professional Certificate Programs from OTC.
The OSHA Training Center's most popular courses have been scheduled to begin in February, giving students time to register and choose a location to attend the courses they need.
"The quality of education demonstrated by our partners including California State University-Fullerton, Associated Builders and Contractors-Southern California Chapter, and Technical Employment Training, Inc. exemplifies the high degree of excellence that OSHA Training Center students have come to expect," Dozier added.
The OSHA Training Center is authorized by OSHA to deliver occupational safety and health training on behalf of OSHA. Students earn and maintain their OSHA credentials as well as earn OTC Continuing Education Units which can be applied to many safety professional designations including the BCSPs CSP, CHST, OHST and ABIH safety credentials.
The OTC instructors are industry safety professionals who bring the latest information, experience and techniques to the state-of-the-art classrooms and incorporate real world experiences into classroom instruction and hands-on learning exercises.
For more information about courses, dates and locations, visit their website at http://www.osha4you.com or call toll-free 866-936-6742.
The Chabot-Las Positas Community College District (CLPCCD) OSHA Training Center is authorized by OSHA to deliver occupational safety and health training on behalf of OSHA and has been conducting OSHA's courses since 2008. Courses offered include OSHA safety standards, OSHA Outreach Trainer courses, OSHA Seminars, environmental courses, and Cal/OSHA courses. The OSHA Training Center specializes in delivering safety training courses in construction, maritime, and general industry throughout California, Arizona, Hawaii, Nevada, Guam, American Samoa and at your facility.
The OSHA Training Center is the only authorized OSHA Training Institute Education Center in Northern California and provides the highest quality safety and health training available based on OSHA most current regulations. Our instructors are industry safety professionals who bring the latest information, experience and techniques to our state of the art classrooms and incorporate real world experiences into classroom instruction and hands-on learning exercises.


Quantitative - such as the location and number of particular wildlife species or the number of observed commercial fishing boats.
Qualitative - such as a detailed description of the state of a cultural site or a written record of an interview with a resource user.
Scientific measurements - such as dissolved oxygen in water or temperature.
Lab analysis - such as samples taken from soils, fish or seaweed.
A well-designed monitoring plan considers how you will use the data before you start collecting it.
Collecting data for data's sake is a sure fire way to waste valuable resources or to lose support for your program. Focus your monitoring efforts on collecting data that can influence change, whether that means influencing your own resource management decisions or negotiating with external government agencies or industry (e.g. to inform referrals, management plans, or high level agreements).
You may want to look at established or best-practice scientific methods to collect data. Talk to university, government, or private sector professionals and researchers to find out what data has already been collected for your region or issue of concern and what methods were used. Evaluate this information to determine if using the same methodology is in your best interest. Using established methods could save you time and money, allow you to compare the data you collect with other data sets, or build broader buy-in to your findings.
For example, if you are collecting data in order to influence the provincial government regarding wildlife management, it is helpful if government accepts your monitoring approach and methodology.
In our experience, you should start with a data collection method that has buy-in. If you are trying to influence the province, ensure they have reviewed your monitoring method and buy into it. The more data we collect, the more we become experts in terms of the moose on Gitanyow territory and on hunting and management issues. If things do go to court, we have all this background information that will be important in influencing the decision. They will do what they can to pick apart your data, so having a qualified professional sign off on the data and research helps.
"In our experience, you should start with a data collection method that has buy-in..."
See the approach that Coastal First Nations took to developing methods for their Regional Monitoring System in these Overview and Methods and Instructions documents. The Ha-ma-yas Stewardship Society has developed several specific data collection manuals for their guardians: archeaological site, eelgrass, clam, and crab.
Inevitably, the community, industry and government will ask questions about your data. Try to ensure that whatever approach you take, your methodology is clear, defensible, and delivers credible data. Regularly review and evaluate your data records and data input processes to ensure data quality is high (often referred to as quality assurance/quality control measures). This will ensure any problems with data collection or data input and management are identified on an ongoing basis and can be rectified. Provide ongoing guidance to staff to improve data quality and consistency.
See the approach that Coastal First Nations took to developing methods for their Regional Monitoring System in these Overview and Methods and Instructions documents. The Ha-ma-yas Stewardship Society has developed several specific data collection manuals for their guardians: archeaological site, eelgrass, clam, and crab. Inevitably, the community, industry and government will ask questions about your data. Try to ensure that whatever approach you take, your methodology is clear, defensible, and delivers credible data. Regularly review and evaluate your data records and data input processes to ensure data quality is high (often referred to as quality assurance/quality control measures). This will ensure any problems with data collection or data input and management are identified on an ongoing basis and can be rectified. Provide ongoing guidance to staff to improve data quality and consistency.
'Coastal Guardian Watchman Regional Monitoring System Overview' shared by the Coastal Stewardship Network is an overview of the Regional Monitoring System (RMS) as it was being used in 2016. The RMS is ever evolving to meet the changing needs and demands of the Nations who participate.
'Archaeological Site Recording', shared by the Ha-ma-yas Stewardship Network, is a manual and quick guide to identifying and recording archaeological site information.
The 'Eelgrass Monitoring Manual' shared by the Ha-ma-yas Stewardship Network provides detailed instruction, methods and information for monitoring and mapping eelgrass in coastal BC, and includes a handy quick guide.
The 'Clam Survey Manual' shared by the Ha-ma-yas Stewardship Network provides detailed instruction, methods and information for surveying clams in coastal BC, and includes a handy quick guide.
The 'Crab Survey Manual' shared by the Ha-ma-yas Stewardship Network provides detailed instruction, methods and information for surveying crab in coastal BC, and includes a handy quick guide.


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text:
Stanley Tahara, PhD
Associate Professor of Molecular Microbiology & Immunology
HMR 510A 2011 Zonal Avenue Health Sciences Campus Los Angeles
stahara@usc.edu
Our laboratory is interested in post-transcriptional regulation. Currently we study miRNA synthesis and function in the sickle cell disease model. Clinical consequences of this genetic illness lead to a spectrum of circulatory and respiratory symptoms originating from a single mutation of the beta-globin gene. In particular pulmonary hypertension results from the vascular occlusion caused by the abnormal red blood cell shape. This leads to expression of vasoactive cytokines and hormones which aggravate and prolong the original vascular insult. Plasminogen activator inhibitor-1 (SERPINE1) and endothelin 1 (EDN1) are two such cell modulators that are dysregulated in acute phases of the illness. We identified miRNAs which are responsible for reversing expression of both SERPINE1 and EDN1; more importantly, we examined in detail the transcriptional regulation and synthesis of these key miRNA mediators. This information has been useful in that we identified a potential pharmacologic therapy that induced specific miRNA expression for the purpose of reducing the expression of SERPINE1 and EDN1.
The second area of interest examines the biological significance of protein arginine methylation of translation initiation factors. We are currently studying the effect of Arg362 methylation of factor eIF4A. The latter is the prototype of DEXD/H box nucleotide dependent helicases. We have found that methylation of Arg362 results in 1) significantly reduced ATPase activity and 2) inhibition of eIF4A assembly with eIF4G into the eIF4F heterotrimer. We believe this example of covalent modification is representative of a previously unknown regulatory circuit for modulating cellular protein synthesis. Our current efforts are directed towards identifying regulators of protein methylation and further examination of eIF4A with respect to mRNA specific effects in protein synthesis.
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Contextual effect of repression of bone morphogenetic protein activity in prostate cancer Endocr Relat Cancer. 2013 Dec; 20(6):861-74. . View in PubMed
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The 3'-untranslated region of hepatitis C virus RNA enhances translation from an internal ribosomal entry site J Virol. 1998 Nov; 72(11):8789-96. . View in PubMed
Variability of persisting MHV RNA sequences constituting immune and replication-relevant domains Virology. 1998 May 10; 244(2):563-72. . View in PubMed
Mouse hepatitis virus nucleocapsid protein as a translational effector of viral mRNAs Adv Exp Med Biol. 1998; 440:313-8. . View in PubMed
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Effects of mouse hepatitis virus infection on host cell metabolism Adv Exp Med Biol. 1993; 342:111-6. . View in PubMed
Effect of eukaryotic initiation factor 4F on AUG selection in a bicistronic mRNA J Biol Chem. 1991 Feb 25; 266(6):3594-601. . View in PubMed
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Beta-globin mRNAs capped with m7G, m27(2)G or m2. 2. 7(3)G differ in intrinsic translation efficiency. Nucleic Acids Res. 1988 Sep 26; 16(18):8953-62. . View in PubMed
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