text:
Reactive oxygen species are indispensable in ovulation
Ketty Shkolnik, Ari Tadmor, Shifra Ben-Dor, Nava Nevo, Dalia Galiani, and Nava Dekel
Departments of aBiological Regulation and
bBiological Services, Weizmann Institute of Science, Rehovot 76100, Israel
PNAS first published January 10, 2011; https://doi.org/10.1073/pnas.1017213108
Ketty Shkolnik
Ari Tadmor
Shifra Ben-Dor
Nava Nevo
Dalia Galiani
Nava Dekel
Edited by R. Michael Roberts, University of Missouri, Columbia, MO, and approved December 15, 2010 (received for review November 29, 2010)
↵1K.S. and A.T. contributed equally to this work.
Ovulation is stimulated by the preovulatory surge of the pituitary luteinizing hormone (LH). Because the ovulatory response is commonly identified with inflammation, we explored the involvement of reactive oxygen species (ROS) in this process. Our experiments show that administration of broad-range scavengers of oxidative species into the ovarian bursa of mice, hormonally induced to ovulate, significantly reduced the rate of ovulation. LH-induced cumulus mucification/expansion, a necessary requirement for ovulation, was prevented by antioxidants both in vivo and in an ex vivo system of isolated intact ovarian follicles. Along this line, H2O2 fully mimicked the effect of LH, bringing about an extensive mucification/expansion of the follicle-enclosed cumulus–oocyte complexes. Impaired progesterone production was observed in isolated follicles incubated with LH in the presence of the antioxidant agents. Furthermore, LH-stimulated up-regulation of genes, the expression of which is crucial for ovulation, was substantially attenuated upon ROS ablation. This system was also used for demonstrating the role of ROS in phosphorylation and activation of the EGF receptor as well as its downstream effector, p42/44 MAPK. Together, our results provide evidence that ovarian production of ROS is an essential preovulatory signaling event, most probably transiently triggered by LH.
cumulus expansion
2To whom correspondence should be addressed. E-mail: nava.dekel{at}weizmann.ac.il.
Author contributions: K.S., A.T., S.B.-D., and N.D. designed research; K.S., A.T., N.N., D.G., and N.D. performed research; K.S., A.T., S.B.-D., D.G., and N.D. analyzed data; and K.S., A.T., S.B.-D., and N.D. wrote the paper.
You are going to email the following Reactive oxygen species are indispensable in ovulation
Ketty Shkolnik, Ari Tadmor, Shifra Ben-Dor, Nava Nevo, Dalia Galiani, Nava Dekel
Proceedings of the National Academy of Sciences Jan 2011, 201017213; DOI: 10.1073/pnas.1017213108


text:
Hong Kong protests
US demands Russia explain ex-Marine's detention on spying charges
US Secretary of State Pompeo says if Paul Whelan's 'detention is not appropriate, we will demand his immediate return'.
Paul Whelan was arrested in Moscow on Friday [Courtesy Whelan Family/Reuters]
The United States wants an explanation for why Russia detained a retired US Marine on spying charges in Moscow and will demand his immediate return if it determines his detention is inappropriate, Secretary of State Mike Pompeo said on Wednesday.
US Ambassador to Russia Jon Huntsman visited Paul Whelan at a detention facility in Moscow and spoke by phone with his family, the State Department said.
The United States had expressed concern through diplomatic channels over delayed access to Whelan, who was detained on Friday, a department spokesman said in a statement.
Secretary of State Mike Pompeo said on Wednesday that if the detention of the former Marine "is not appropriate, we will demand his immediate return".
In announcing Whelan's arrest three days after he was detained, the Russian Federal Security Service said he was caught "during an espionage operation", but gave no details.
Whelan, 48, was in Moscow to attend a wedding when he suddenly disappeared, his brother David Whelan said on Tuesday.
Pompeo, speaking in Brazil, said the US had "made clear to the Russians our expectation that we will learn more about the charges and come to understand what it is he's been accused of and, if the detention is not appropriate, we will demand his immediate return."
Whelan's family said in a statement David Whelan posted on Twitter: "We are deeply concerned for (Paul's) safety and well-being. His innocence is undoubted and we trust that his rights will be respected."
The Russian spying charges carry a prison sentence of up to 20 years.
David Whelan said in an interview that his brother had been to Russia several times previously, so when a fellow former Marine was planning to marry a Russian woman in Moscow he was asked to go along to help out.
The morning of his arrest, he had taken a group of wedding guests on a tour of the Kremlin museums. The last time anyone heard from him was at about 5pm local time, and he failed to show up that evening for the wedding, his brother said.
"It was extraordinarily out of character," he said.
Strained relations
The State Department said on Monday it had received formal notification from the Russian Foreign Ministry of the arrest. David Whelan said the family was told by the US Embassy in Moscow that they had not been able to speak to his brother.
David Whelan said he has no idea why his brother was targeted by the Russian security services.
"I don't think there's any chance that he's a spy," David Whelan told CNN on Wednesday.
Paul Whelan did multiple tours in Iraq with the Marine Corps, his brother said. He now lives in Novi, Michigan, and is director of global security for BorgWarner, where he has worked since early 2017.
The arrest comes as US-Russian ties are severely strained, in part over an investigation into Russian meddling in the 2016 presidential election.
A Russian gun rights activist, Maria Butina, is in US custody after admitting she acted as a secret agent for the Kremlin in trying to infiltrate conservative US political groups as Donald Trump was seeking the presidency. She pleaded guilty in December to a conspiracy charge as part of a deal with federal prosecutors.
Russian President Vladimir Putin has claimed that the case is fabricated and that Butina entered the guilty plea because of the threat of a long prison sentence
SOURCE: Reuters news agency

redpajama_set_name: RedPajamaCommonCrawl


text:
How Are Your Investments Doing Lately? Receive A Free, No-Obligation 2nd Opinion On Your Investment Portfolio >
Weekly Financial Market Commentary
Our Mission Is To Create And Preserve Client Wealth
Could it be the upside surprises?
U.S. stock markets have marched higher despite a pandemic, an economic downturn, and social justice protests – and a lot of people have wondered why.
Greg Rosalsky of Plant Money spoke with Nobel Prize-winning economist Robert Shiller about, "…the mass psychology of a gazillion buyers and sellers, who each are telling themselves their own stories about why they're making the trades they're making."
Rosalsky and Shiller discussed some narratives that purport to explain recent market performance, including:
· Quarantine boredom. Matt Levine of Bloomberg has postulated "…a lot of individual investors buy stocks mainly because it's fun, and that the more fun stocks are, and the less fun everything else is, the more they'll buy stocks. In a pandemic, when people can't really leave their house and sports are canceled, there is a lot less fun to be had elsewhere…so people buy more stocks."
· Big, publicly–traded companies are safe. This theory suggests businesses hit hardest by the economic downturn often are not traded on stock exchanges. In a separate article, Rosalsky cited former technology executive Eric Schmidt who wrote, "Gigantic corporations, which have deep pockets, fancy accountants, huge legal teams, and access to international financial markets, are also better equipped to weather shocks than your local hardware store or small manufacturing company."
· Don't fight central banks. "The Fed is using its unlimited money-printing machine to single-handedly prop up the stock market. 'The Fed is itself an important narrative,' Shiller says. In reality, he says the Fed's magic over the real economy is limited. But its statements clearly move markets, and it has lots of power as a storyteller," reported Rosalsky.
On Saturday, Lisa Beilfuss of Barron's offered another narrative. She reported:
"…upside economic surprises over the past two weeks – mortgage applications hit the highest level since 2008, retail sales rose at the fastest pace ever, and U.S. businesses added 2.5 million jobs in May instead of cutting an anticipated eight million, to name a few – are even better than they look and offer at least some proof that the stock-market rebound was driven by expectations for improving fundamentals…It's about the magnitude of the surprises versus Wall Street's expectations."
We don't know which narratives were responsible, but major U.S. stock indices moved higher last week.
What do you think? In recent years, we've learned a lot about why investors do the things they do. For instance, we now know investors are not the omniscient, rational decision-makers economists believed them to be. Investors have built-in biases that sometimes cause them make errors in thinking.
One of those biases is known as confirmation bias. Investors (and non-investors) have a tendency to seek data that reinforces their beliefs and ignore data that suggests they're wrong. Recently, sentiment data has been published that supports diverse ideas about the direction of the economy and stock markets. For example:
· Consumer sentiment was up month-to-month, suggesting Americans were more optimistic about their personal finances and current economic prospects in June than they were in May. However, sentiment remains down year-to-year and below the baseline, which is consumer sentiment in 1966 (the year the survey began).
· Investor sentiment was down week-to-week. Almost one-half of participants (47.8 percent) in the American Association of Individual Investors (AAII) Sentiment survey were feeling bearish last week, while one-fourth (24.4 percent) were feeling bullish. The bulls were down 9.9 percent week-to-week, and the bears were up 9.7 percent week-to-week. Some investors consider the AAII survey to be a contrarian indicator, meaning they think the survey's prevailing sentiment is incorrect. In this case, contrarians would be bullish.
· Money managers think the market is overvalued. Bank of America surveyed 212 money managers with $598 billion under management and reported 78 percent think the stock market is pricey. Survey participants indicated the most crowded trades were U.S. technology and growth stocks, reported John Melloy of CNBC.
When data supports varied opinions, how can investors avoid mistakes? One of the best ways is to work with an advisor who has a clearly defined process and who will help you develop a plan to meet your financial goals.
Weekly Focus – Think About It
"A public-opinion poll is no substitute for thought."
–Warren Buffett, Investor and philanthropist
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Pandemics - Protests - Wildfires - Market Crashes - Recession If someone ever tries to tell the story of 2020 on film, it will take more movies than Star Wars....
Investment advice offered through Research Financial Strategies, a registered investment advisor.
* This newsletter and commentary expressed should not be construed as investment advice.
* Government bonds and Treasury Bills are guaranteed by the U.S. government as to the timely payment of principal and interest and, if held to maturity, offer a fixed rate of return and fixed principal value. However, the value of fund shares is not guaranteed and will fluctuate.
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* All indexes referenced are unmanaged. The volatility of indexes could be materially different from that of a client's portfolio. Unmanaged index returns do not reflect fees, expenses, or sales charges. Index performance is not indicative of the performance of any investment. You cannot invest directly in an index.
* The Dow Jones Global ex-U.S. Index covers approximately 95% of the market capitalization of the 45 developed and emerging countries included in the Index.
* The 10-year Treasury Note represents debt owed by the United States Treasury to the public. Since the U.S. Government is seen as a risk-free borrower, investors use the 10-year Treasury Note as a benchmark for the long-term bond market.
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* International investing involves special risks such as currency fluctuation and political instability and may not be suitable for all investors. These risks are often heightened for investments in emerging markets.
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...because that's just how things roll over at my house. :) Shorter post today (because work has been overwhelming) but I wanted to touch base and frankly, relax for a few minutes.
It's gone pretty well, but I've been dealing with a sore calf muscle again, which had me worried over the weekend. I've been trying to rest it a bit and not dance on it as much as possible until a few days before the show. The other thing I was fretting over was my costume. I'm going to be using my troupe bra and belt set not only for troupe numbers, but for my solo as well just with a different skirt and matching gauntlet gloves (HELLO NEON ORANGE!!) so I *really* need it to fit me correctly. And as I mentioned the other day, the belt was giving me a difficult time staying up. My mother-in-law altered it for me, so I was anxious to practice in it, with both skirts, and put it through its paces to assure the fit was good.
I got the kids in bed last night and went to town. I tried the orange skirt first and slipped the belt over it. The fit is now *perfect* (God bless my mother-in-law, who has sewed snaps on this thing no less than 4 times). I shimmied around, and did my solo in it, and the belt now sits at a perfect spot and doesn't slip down. Slam dunk.
The top however...She tightened it at the neck as I had requested, and the fit is much better, but...something still felt off, Far too much movement at that level for my comfort. As I danced, I kept looking down to assure that I wasn't flashing my neighbors.
It was official. I CANNOT LIVE LIKE THIS ANYMORE! WHY, dear God, WHY do these costume designers not make costumes that actually FIT a a MOVING BODY!! It's just absurd, there's zero give or contour to these things. I man-handled it a bit, looking for ways that I could get it lie more fitted to my body, but I started to despair. I cannot get into my drum solo (my *very favorite* type of dancing) while worrying that my costume may make it an entirely unintended type of show, kwim?!
So I came up with an idea. I could sew some fabric into the middle of the top, a modesty panel of sorts, to keep things more contained. And I create knitted and crocheted fabric, so did I have any bright pink yarn? Why yes I did!!! Away I went.
Next thing you knew, I had a crocheted rectangle. I sewed a crystal onto the front of it, and tacked the entire shebang into the cleavage area of my top. Can I just say, it looks kind of awesome. :0 I wish I had taken a picture. When Mike got home from play rehearsal, I showed it to him, and he didn't even understand what I had done because he thought the entire top looked like it came that way.
More news tomorrow, when I'm hopefully not having a nervous breakdown over the weekend that we have scheduled.


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HomeNewsA teacher's messages of despair from the front line
A teacher's messages of despair from the front line
By Chris McGovern
TODAY, the Conservative Woman publishes the first of two letters of complaint from a practising supply teacher to her school bosses after which she wrote in desperation to education correspondent Chris McGovern:
'At the end of a lesson, one boy came up and was fiddling with the things on the teacher's desk. I told him it wasn't his area of the classroom and to leave his teacher's things alone. He grabbed a pencil and walked off. I followed him, held out my hand and told him to give me back the pen. His response was to hold the pen up high, throw it across the room shout, "Go fetch".'
This picture of the teacher-pupil relationship has come to me from a practising teacher. To protect her identity and her career I shall call her Anna. She has been brave enough to send me a copy of letters she has written to management at two schools where she worked recently as a supply teacher.
'. . . so appalled was I at the behaviour I encountered there. One school did not bother to even acknowledge my e-mail. The other school sent such a whitewash of a letter, so played down the behaviour I'd seen, that I was disgusted.'
It takes some guts to break the code of silence that schools impose on their staff. Her experience, sadly, is neither atypical or unusual. It is, though, supposed to be 'hush-hush'. Head teachers prefer that their teachers do not speak out. Mum's the word!
Even the 40 per cent or more of new teachers who flee the job within five years are inclined to say little beyond vague references to poor discipline as a reason for calling it a day. Their ritual humiliation in the classroom is not something to which they wish to admit – understandably so.
I have written before that, with a recruitment and retention crisis, the teaching profession and the Department for Education need to face up to some harsh realities about the job.
Some of those realities are reflected in Anna's two letters. They were both written during the past twelve months but at different schools in a rural, non-crime ridden part of England.
Extracts from Letter 1
. . . in each class there were a small number of students who were pleasant, cooperative and helpful and who tried to get on with their work.
However, they didn't get much work done at all, because of the bad behaviour of the rest of their classmates and the noise that they made:
1. Pupils having to be told sometimes four times to take off their coat or to take out something to write with when they entered the classroom.
2. Several pupils were given verbal warnings and then the second time told to go to (colleague's name), but they refused to leave the classroom.
3. Papers were thrown up in the air and allowed to scatter on the floor. When I asked a boy (who I knew had been throwing paper aeroplanes and generally contributing to the mess on the classroom floor) to help clear up, it was met with, 'You do it. You're older and I'm not your slave.'
4. I moved a girl to separate her and her friend, as they were talking despite being told to stop several times. For this I was told, 'You're pathetic'.
5. I asked a pupil 'Could you do x?' (give out the textbooks, perhaps?) and the response was 'You haven't said "please". Say "please" and perhaps I will.'
6. The computer at the teacher's desk was switched off at the wall. I was on the opposite side of the classroom from the teacher's desk, and I looked round to find a student sitting there in the teacher's place.
7. I confiscated something (some earphones I believe) until the end of a lesson and put them in the drawer of the desk. The pupil was sent to (colleague's name), and wanted to take the earphones before he went. I replied that he would have to come back to the classroom at the end of the lesson to collect them. He came up to the desk, calmly opened the drawer and took out the earphones.
8. I was making a list of those I'd given verbal warnings to and one boy snatched it out of my hand and ripped it up.
9. I was sworn at (the f word).
10. I was imitated a number of times.
11. A girl walked in unannounced three minutes before the end of one period, with 'I'm in your lesson, darlin'. I was also called 'bruv' and 'boy'.
12. Pupils in Year 10 and 11 were loudly talking to each other, and calling across the classroom using sexualised language, talking about Tinder and Grindr, and a rhyme that I think went: 'Bend over and touch your toes, let me show you where the rocket goes.'
13. Another boy took a sizeable stack of untouched lined paper, screwed it up and threw it in the bin.
Welcome to the teaching profession! Small wonder that we have a problem attracting and keeping teachers. Tomorrow, I will publish Letter 2 from Anna. Anyone considering a career in teaching would be advised to read it.
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Chris McGovernhttp://www.cre.org.uk
Chris McGovern is the Chairman of the Campaign for Real Education. A retired head teacher with 35 years' teaching experience, Chris is a former advisor to the Policy Unit at 10 Downing Street under two Prime Ministers.


Inverse Laplace transforms of stiff systems can be efficiently computed provided the system is of moderate order. A process is described whereby similar efficiency can be obtained for high-order systems.
W.E. Thomson . Evaluation of transient response. Proc. Inst. Elect. Electron. Engrs.


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Membro del Partito Unionista Democratico (DUP), è stata Ministro dell'ambiente dell'Irlanda del Nord dal 2007 al 2008, Ministro per l'impresa, il commercio e gli investimenti dal 2008 al 2015 e Ministro delle finanze e del servizio civile dal 2015 al 2016. Ha coperto due volte l'incarico di primo ministro ad interim sostituendo Peter Robinson nel 2010 e nel 2015.

L'11 gennaio 2016 è diventata Primo ministro dell'Irlanda del Nord con pieno incarico ed è stata rieletta dopo le elezioni del 6 maggio 2016. È la prima donna a ricoprire questa carica. Il 9 gennaio 2017 è stata comunque costretta a dimettersi con la defezione del vice primo ministro Martin McGuinness. Dopo le elezioni generali anticipate del 2017, non è riuscita a formare un governo di coalizione con il Sinn Féin, aprendo la strada a una crisi politica senza precedenti in Irlanda del Nord. È tornata al suo ruolo l'11 gennaio 2020. Ha annunciato le sue dimissioni nell'aprile 2021 sullo sfondo di una crisi interna del DUP legata alla sua gestione della Brexit e alle conseguenze dell'accordo commerciale con l'UE. Si è dimessa dal suo incarico di capo del DUP il 28 maggio 2021 e dal suo incarico di primo ministro il 14 giugno.

Biografia
Figlia di un poliziotto e di una casalinga di Belfast, è l'ultima di tre sorelle. All'età di otto anni è testimone dell'aggressione a suo padre, effettuata da membri dell'IRA. A seguito di tale evento, che causò il ferimento del genitore, tutta la famiglia si è trasferita a Lisnaskea. Si è laureata in giurisprudenza alla Queen's University di Belfast e ha svolto l'attività forense a Portadown e Enniskillen finché, nel 2003, decide di dedicarsi alla politica.

Carriera politica

Elezione parlamentare e incarichi ministeriali nell'esecutivo regionale

Solo poche settimane dopo le elezioni per l'Assemblea dell'Irlanda del Nord del 2003, in cui Foster ha ottenuto un seggio sotto la bandiera del partito UUP nel collegio di Fermanagh e South Tyrone, si è dimessa il 18 dicembre 2003, insieme ai suoi due colleghi di partito Jeffrey Donaldson e Norah Beare dell'UUP, e il 5 gennaio 2004 è diventata membro del Partito Unionista Democratico (DUP), l'altro grande partito unionista dell'Irlanda del Nord. Le ragioni del cambio di partito erano l'insoddisfazione per il corso dell'UUP sotto il leader del partito David Trimble.

All'interno dell'Esecutivo dell'Irlanda del Nord ha ricoperto l'incarico di Ministro per l'Ambiente dal 2007 al 2008, Ministro per l'Impresa, il Commercio e gli Investimenti dal 2008 al 2015 e Ministro delle finanze dal 2015 al 2016.

Primo ministro dell'Irlanda del Nord

Dopo che il primo ministro Peter Robinson si è dimesso a causa di controversie con i partiti repubblicani irlandesi, Foster è succeduta al primo ministro il 10 settembre 2015. Il fatto che Foster sia rimasta l'unico politico del DUP nel governo regionale dell'Irlanda del Nord è stato giustificato dal fatto che il Sinn Féin e l'SDLP non dovevano essere autorizzati ad assumere l'importante incarico sul Dipartimento delle finanze e l'ufficio di Primo ministro. Il 20 ottobre 2015 il suo predecessore Peter Robinson ha ripreso l'incarico di Primo ministro. Un mese dopo, il 19 novembre 2015, ha annunciato le sue dimissioni dalla carica di Primo ministro e dalla carica di presidente del DUP per motivi di salute. Il 17 dicembre 2015 il DUP ha eletto Arlene Foster nuovo leader del partito. Dall'11 gennaio 2016 è ufficialmente Primo ministro del governo regionale dell'Irlanda del Nord, succedendo a Peter Robinson.

Sviluppi nel 2017
A seguito delle dimissioni dei ministri del Sinn Féin, il 2 marzo 2017 è stata rieletta al parlamento regionale, in cui il DUP guidato da Arlene Foster ha subito perdite significative, ma era ancora il partito più forte. Nelle elezioni generali dell'8 giugno 2017, tuttavia, il DUP ha ottenuto il suo miglior risultato nella storia del partito nelle elezioni britanniche e ha ottenuto 10 dei 18 collegi elettorali dell'Irlanda del Nord, consolidando così nuovamente la posizione di Foster. Dopo le elezioni, si sono svolte le trattative tra il DUP e il Partito Conservatore britannico sulla tolleranza di un governo di minoranza conservatore a Westminster da parte del DUP.

All'inizio del dicembre 2017 Foster ha impedito al DUP di svolgere i negoziati sul recesso dall'UE del Regno Unito tra il primo ministro Theresa May e l'Unione europea in una teleconferenza. I negoziati erano strutturati su uno status speciale in realtà già concordato per l'Irlanda del Nord riguardo il mantenere la libera circolazione dei merci e persone tra l'Irlanda e l'Irlanda del Nord e svolgere controlli tra la Gran Bretagna e l'Irlanda del Nord. Foster ha rifiutato di approvare perché solo l'Irlanda del Nord potrebbe essere trattata allo stesso modo del resto del Regno Unito per il suo partito.

Sviluppi dopo il 2017 e ritiro
Dopo che il Regno Unito ha lasciato l'UE, il DUP è stato esposto a notevoli tensioni. In particolare, il Protocollo dell'Irlanda del Nord, entrato in vigore il 1º gennaio 2021, è stato controverso nel partito e nel suo elettorato. In base a tale accordo, sono stati previsti controlli aggiuntivi per alcune merci importate in Irlanda del Nord dal resto del Regno Unito nei porti dell'Irlanda del Nord. Gli oppositori dell'accordo sostenevano che avrebbe creato un confine doganale quasi invisibile nel Mare d'Irlanda tra l'Irlanda del Nord e il resto del Regno Unito. Tuttavia, Foster, che si è opposta a questo protocollo, non è stata in grado di affermarsi contro il governo di Boris Johnson su questo tema. Foster è stata anche vista dai suoi critici come "troppo debole" o troppo liberale su altre questioni. Ad esempio, è stata criticata la sua astensione al voto sul divieto della terapia di conversione (la maggioranza del DUP ha votato contro), così come la sua approvazione alla liberalizzazione della restrittiva legge nordirlandese sull'aborto. Anche il suo sostegno all'Irish language Act, che ha fornito maggiori finanziamenti e uno status ufficiale per la lingua irlandese, è stato oggetto di critiche.

Il 27 aprile 2021 è stato pubblicato un articolo in cui Foster era sospettosa. È stato firmato da 20 dei 28 parlamentari del DUP a Stormont e 4 degli 8 parlamentari del DUP. Foster ha anticipato il suo voto dichiarando le sue dimissioni da presidente del DUP il 28 maggio 2021 e da primo ministro alla fine del giugno 2021. Ha rinunciato alla carica di capo del governo il 14 giugno. Come successore il suo partito nominò Paul Givan.

Scandalo sulla promozione delle energie rinnovabili
Nel 2016 si è sviluppato uno scandalo sul cosiddetto Renewable Heat Incentive (RHI, "Incentivo sull'uso delle energie rinnovabili", indicato anche dalla stampa come "Cash for Ash"). Nel 2012, l'allora governo dell'Irlanda del Nord ha lanciato un'iniziativa per incoraggiare i proprietari di case a utilizzare incentivi finanziari per trasformare i loro sistemi di riscaldamento dai combustibili fossili alle energie rinnovabili. Arlene Foster era allora ministro responsabile di questo programma. Tuttavia, in seguito divenne evidente che il programma non era stato attentamente pensato. Soprattutto, il fatto che il contributo erogato ai gestori del riscaldamento fosse superiore ai costi di riscaldamento sostenuti - più si riscaldava, più sussidi si riceveva - era garantito per un periodo di 20 anni e non era limitato. Ad esempio, i proprietari di case che in precedenza non avevano alcun riscaldamento avrebbero potuto avere l'installazione di un sistema di riscaldamento interamente finanziato dal contribuente. Ancora più gravi, tuttavia, sono stati i casi in cui gli immobili commerciali e agricoli parzialmente sfitti sono stati riscaldati tutto l'anno. Gli informatori hanno segnalato casi derivanti di 15 milioni di sterline dall'installazione e dal funzionamento durante tutto l'anno di un sistema di riscaldamento in una proprietà vuota o in una proprietà che non necessitava di riscaldamento. Gli esperti presumevano che l'RHI sarebbe costato ai contribuenti dell'Irlanda del Nord fino a 20 milioni di sterline all'anno nei futuri 20 anni; tuttavia, c'erano anche stime più basse e più alte. Jonathan Bell, un ex collega del partito DUP di Arlene Foster, ha sollevato gravi accuse in questo contesto nel dicembre 2016, in particolare al discorso del Primo ministro. A quel tempo, il governo nordirlandese ignorò tutti gli avvertimenti consultivi. I partiti che non hanno partecipato al governo nordirlandese dalle elezioni del 2016 SDLP e UUP hanno quindi chiesto le dimissioni di Foster, che sono state rifiutate. Il 9 gennaio 2017 il vice di Foster Martin McGuinness (Sinn Fein) si è dimesso dal suo incarico di governo, citando lo scandalo RNH.

Note

Altri progetti

Collegamenti esterni

Primi ministri dell'Irlanda del Nord
Politici del Partito Unionista Democratico
Politici del Partito Unionista dell'Ulster
Leader del Partito Unionista Democratico

redpajama_set_name: RedPajamaWikipedia


Istanbul Electric Tramway and Tunnel Operations (IETT), Labor Day, the official holiday 1 May Tuesday made a statement about the expeditions.
IETT said in a statement, acak 1 May 2018 On Tuesday, our lines will run on Saturdays and our Found Office will be closed. It is announced to our passengers Yol.


J Clin Invest. 2018;128(1):1–3. https://doi.org/10.1172/JCI97861.
The combined efforts of Doug Lowy and John Schiller form the basis of the biology behind the vaccines for HPV (human papillomavirus), which underlies cervical cancers as well as oropharyngeal cancers. With widespread uptake, these vaccines have the potential to wipe out these cancers in a generation. The JCI spoke with Schiller and Lowy (Figure 1) from the National Cancer Institute when they were in New York City to collect the 2017 Lasker~DeBakey Clinical Medical Research Award. Watch the full interview at www.jci.org/videos/cgms to find out more about HPV biology, how exciting it was to hear the early results of the vaccine trial, and whether they have ever fought with each other.
John Schiller and Doug Lowy on September 14, 2017, in New York City. Image credit: Alexey Levchenko.
JCI: Where did you grow up?
Schiller: I grew up in Madison, Wisconsin, and was quite a rambunctious kid. I was very active, but also read a lot. My parents weren't particularly academic. My father had a small business where he sold John Deere tractors, and my mom was a homemaker. We had a lot of emphasis on education, but I didn't have role models in terms of getting into science. Initially, I thought I wanted to be a park ranger because I liked the idea of natural history and being out in the woods. But I got to realize that really, what park rangers do is deal with unruly tourists.
I was always interested in science; I studied all the plants and animals that were in the area and could identify them. I always had a very scientific bent, ever since I was little, but I was one of these people who never wanted to commit. I didn't have an academic major until my junior year of college, but I took all the prerequisites for molecular biology, from the physics to the math. I eventually knew I wanted to be a researcher and decided to get a PhD. I went into microbiology because that's where the best molecular biology was being done — E. coli and their phages (bacterial viruses) were where some of the most interesting molecular biology was being done.
Lowy: I was born in the Bronx in New York City and grew up there and stayed in the Bronx, more or less, through high school. My parents were both general practitioners, working in the Bronx. I thought from a very early age that I would follow in their footsteps. Being in research is something that I did not envision and didn't seriously think about until I was in medical school and beyond.
I was a good student, but I was very interested in sports, electric trains, building model cars, and things like that. I had very little interest in science, more interest in disease and health, as my parents would tell me about things like the relationship between cigarette smoking and cancer because that was being identified when I was growing up.
I actually think of myself much more as being a follower rather than a trailblazer. I followed in my brother's footsteps when I went to college. I followed in my mother's footsteps when I went to medical school — I really think of myself as imitating people that I respect rather than striking out on my own.
I became very interested in infectious diseases as a result of taking microbiology when I was a medical student. I was particularly intrigued by the positive symbiotic relationship between microorganisms and the host. I had always thought about microbes as being universally harmful rather than potentially beneficial. And the balance between being inoffensive or neutral, being beneficial and being harmful, was something that seemed really intriguing to me. I did some research on interferons during medical school with Jan Vilcek. Luckily for me, Dr. Vilcek thought that I had potential, which led to my getting a position at the NIH where I received really extensive training in laboratory-based research and really got launched on my research career.
JCI: That was going to be my next question: How did you end up at the NIH? Did you know that you wanted to pursue academic medicine?
Lowy: No, the Vietnam War is what got me to the NIH. When I graduated from medical school, it was still at the time where the Selective Service System was in existence. Recent medical school graduates, if they were male, basically had to do some kind of uniform service activity. Most people ended up going to Vietnam. But you could, if you were selected, go to the NIH for research training, and that's what I ended up doing.
Initially, I worked on retroviruses, which is what my training was when I was first at NIH in the Institute of Allergy and Infectious Diseases. And then my research went into the retroviruses that had oncogenes — acute transforming retroviruses. My interests went on to papillomaviruses as another version of viruses that could cause cell transformation, but that class of viruses was much less studied than the retroviruses were.
JCI: So John, how did you decide to do your postdoc with Doug?
Schiller: I was starting to do some strategic thinking about science. My PhD, which was in diphtheria biology, was quite mediocre. I was actually a little bit disenchanted with bacterial pathogenesis because it seemed very balkanized. Everybody was studying their little bug; there were no overriding common elements that were interesting. This was the time that tumor virology was coming up, and I thought it would be really cool to study. But my PhD wasn't strong enough, I didn't think, to apply to the really super top labs. I went to the Fred Hutchinson where they had a very strong tumor virology group, and I asked the faculty, Who's up-and-coming in the field and a really good person? At the top of everybody's list was Doug.
I applied to his laboratory to work on retroviruses, but he said, "What you're propose is a nice thing, but I'm just starting to work on papillomaviruses." My reaction was, Papillomaviruses? What? I read a little bit about the limited knowledge, thought, Wow! This is really a time to get into papillomaviruses. I wrote back with a project related to papillomaviruses, which we actually ended up doing.
JCI: Doug, I take it he didn't sell himself as doing a mediocre PhD when he applied?
Lowy: He wrote a terrific proposal, and I was very impressed. John clearly saw the potential for studying papillomaviruses. Essentially, nothing was known about their molecular and genetic organization. We spent a fair amount of time using a model system, the bovine papillomavirus (BPV), to work out the molecular genetics.
JCI: John, you've before told the story of your first aha moment — the seminar you attended at the NIH from Harald zur Hausen — talking about HPV underlying cervical cancer. Did you come back to Doug and say, No more BPV; we're studying HPV!
Schiller: No. What we were studying on BPV was also significant. But we started to transition to HPV because we realized that there were important differences between the way BPV transforms cells and the way HPVs do. For instance, we looked to see whether BPV interacted with p53, and we couldn't find any interaction. But for HPV, that's one of its primary activities: it induces degradation of p53, a critical tumor suppressor. As we started to realize that all the different papillomavirus weren't doing it the same way, we transitioned more into studying HPVs.
JCI: At what point did you start thinking about a vaccine?
Lowy: In the early '90s. We had been convinced from the molecular biology that HPV was important for cervical cancer. We were thinking about the structural proteins of the virus instead of the genes and the proteins that regulate the virus. And quite by accident, the first experiments that we ended up doing were experiments that were able to test whether expressing the major protein of the papillomavirus would self-assemble and form virus-like particles (VLPs). Another thing is that Reinhard Kirnbauer, who was the dermatologist postdoctoral fellow in the lab, was willing to do this high-risk research. We were very fortunate that he was able to make VLPs in the very first set of experiments where he expressed BPV L1 [one of the two outer viral capsid proteins]. At that point, it was a question of asking, Well, might this be a vaccine?
JCI: You were puzzling over how to get the HPV L1 capsid protein to form VLP — at what point did you have the revelation that the HPV16 strain you were using had a mutation that was causing it not to self-assemble correctly?
Schiller: We were really disappointed because when Reinhard tried again to express HPV L1 in insect cells, with the exact same vectors from HPV16, we could barely find any particles at all. About the same time, we started to make VLP from a rhesus monkey papillomavirus. We wanted to show we could induce high titers of antibodies that block infection in a nonhuman primate. This rhesus papillomavirus turns out to actually be very closely related to HPV16. When we tried to make the VLPs of that strain, it worked just as well as with BPV. We thought that it wasn't that there were two classes, one that did assemble and one that didn't; the reason why we were not successful was maybe because BPV is a cutaneous virus. It replicates in the normal type of skin on the cow, and HPV is more mucosal. We thought maybe there was a difference between these two classes. But rhesus papillomaviruses cause cervical cancer in monkeys. That's when we really thought the most likely possibility was that HPV16, which had been used in most of the labs around the world, that Harald zur Hausen had originally isolated, was a mutant, because it was isolated from a cancer. And cancers are notoriously genetically unstable.
JCI: Once you got the VLPs to assemble properly using a nonmutant HPV strain, you had some promising data that led you to start a pilot human clinical trial with the NCI at Hopkins in a small group, and it was amazingly successful. Do you think that the unique nature of the NIH was what allowed you to get to that point in the beginning?
Lowy: The freedom of the intramural program at the NIH was critically important in large part because we had never worked in this area before. We had studied the genes that were responsible for transformation or regulating gene expression, but we had never studied the structure, had no background in immunology or in vaccinology. One of the big advantages of the intramural program is that you have leveled resources.
In retrospect, we were fortunate that, because we had worked on BPV, we were able to show not only that we could get self-assembly of particles, but because we had developed a neutralization assay in vitro, we could also show very high levels of neutralizing antibodies, much higher than with most other vaccine types. And that gave us the positive control to then be encouraged to go forward with the human papillomavirus studies. Other people who were working in this area tended to focus on HPV first, for which there either was no neutralization assay or a very cumbersome one.
JCI: How many cervical cancer cases are there per year, and how did your idea get carried forward to larger trials?
Schiller: There's about half a million worldwide and about 250,000 deaths. From the point of view of the pharmaceutical industries, I think their biggest issue was that the track record for sexually transmitted disease vaccines at that point was miserable. People had tried to do herpes virus vaccines that seemed to work in animals, and they didn't work in people, same for chlamydia. People had been working on HIV vaccines, and none of them seemed very promising. The biggest intellectual hurdle was that HPV isn't like a flu vaccine where you may be exposed once or twice. If you have a sexual partner, you may be getting exposed repeatedly over a course of years because these viruses tend to persist.
It was really a leap of faith for Merck and GSK to spend hundreds of millions of dollars to test our vaccine and see whether they would work. Merck did an HIV vaccine trial during the time the HPV vaccine was working great. With the HIV vaccine, they spent hundreds of millions of dollars and they got nothing out of it, other than knowing that their particular vaccine doesn't work in people.
JCI: You had seen some initial positive data, but did you know that it was going to be as successful as it was?
Lowy: Certainly not immediately. For us, finding out about the results of the monovalent HVP16 trial that Merck conducted — published in 2002 but it was first announced in 2001 at a papillomavirus meeting — was simply astounding because there were 41 cases of HPV16 infection in that clinical trial. All 41 cases were in the placebo group and zero in the HPV16 group. For us, this clearly indicated this was going to work and be highly effective because you just don't get results like that ordinarily in a clinical trial.
JCI: Did you have some champagne when you found out?
JCI: Okay, I'll change my question: Did you have a caipirinha?
Schiller: I had a caipirinha afterwards. I do remember that, absolutely.
JCI: Doug, you have been deputy director of the NCI since the '90s and, for the last 2.5 years, the acting director of the NCI. What made you take on more administrative roles?
Lowy: I have gotten a tremendous amount from being in the intramural program at NCI and wanted to see whether I might be able to do more as a way of giving back. In the '90s, I started out as deputy director of the intramural NCI program. In 2010, when Harold Varmus became the NCI director, he asked if I would become the deputy NCI director. But before I said yes or no, I turned to John and said, "Should I do this?" And he said yes. I asked the person who was the director of the intramural program, and he thought I should. And then, I asked the most important person, and my wife said I should too. So I ended up doing it. Then, when Harold left, I became the acting director, and it has been very interesting.
Part of what I love about doing research is being able to address important questions. Many of them are basic; some have translational and clinical implications. But being involved at the policy level gives you an opportunity to do more, although not as directly. You can help researchers with development of their careers. You can try to put more emphasis in one area of research as opposed to another. There are so many different ways in which you can try to help the cancer research enterprise. A very important part of it for me has been to strongly support investigator-initiated research because to me, that is very important for leading to the clinically important interventions of tomorrow.
Schiller: Doug is a more outstanding scientist and, at the same time, better administrator than anybody I've ever met. He can juggle more balls in the air at the same time than anybody and do a really great job for all of them.
JCI: If you could not have been a doctor or a scientist, what do you think you would have done in your lives? What would have kept you engaged?
Lowy: If I had the talent, my first two choices would either to have been a wonderful miler or 1,500-meter runner. Second choice would have been to play football in the NFL. But when you're talking about what might have been feasible, I would have really liked to have been a high school biology teacher.
Schiller: Maybe a professional trout fly fisherman. I was always really an academic, and that is the perfect thing for me. So if I couldn't do science in an academic setting, I probably would have been a historian studying the flow of ideas in cultures, particularly when distinct cultures interact.
Reference information: J Clin Invest. 2018;128(1):1–3. https://doi.org/10.1172/JCI97861.


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Alstom's automatic MP14 metro deploys on Line 14 extension
French company Alstom has announced that its new automatic MP14 metros have been deployed on Line 14 extension to the station Mairie de Saint-Ouen in Paris, France.
In total, eight of Alstom's 14 sites are involved this project in France. Credit: Alstom 2020.
Operated by RATP, the MP14 metro will now cover the entire Line 14, from Olympiades to Mairie de Saint-Ouen.
The automated, rubber-tyred metro is made up of eight cars and has been financed by Île-de-France Mobilités, the organisation that handles the Paris transport network.
Alstom chairman and CEO Henri Poupart-Lafarge said: "We are particularly proud to see the MP14 metros entering commercial service as far as the Mairie de Saint-Ouen station.
"These metros, which we designed and manufactured at eight Alstom sites in France, now serve the head office of the Alstom group.
"The arrival of the MP14 metros will directly improve the daily lives of tens of thousands of people, including the 3,000 employees of the Alstom group based in Saint-Ouen.
"This site is the group's global headquarters and the biggest centre of railway expertise in Europe."
Alstom claimed that the design of the train will improve passenger experience and delivers energy efficiency, ease of maintenance and reduced costs.
The metro features full electric braking system, which will help decrease fine particle emissions, as well as air pollution by up to 17%.
With a 95% recyclability rate, MP14 is also 40% quieter with -2dB noise level.
Each consisting of eight cars, around 20 automated metros will be delivered next year for Line 14.
Production of the six-car automated metros for Line 4 is currently at the pre-production and testing phase.
The five-car metros for Line 11 will be manufactured in Q4 2020 with qualification tests to take place in 2021.
In total, eight of Alstom's 14 France-based sites are involved this project.
DAMM Cellular Systems
TETRA and DMR Communication Systems
Frequentis
Emergency Response and Network Communication Systems
Malux Finland
GSM-R Equipment for Reliable Railway Communication


It's worth noting that you can't have four points in the plane with just a single distance, because if all the points are equi-distant then they will have to be at the vertices of a tetrahedron, which is most definitely non-planar.
In general, four points in the plane will determine six distances, as there are six pairs, and there is no reason to expect that any of those distances would be repeated. But we can choose to place the points to create duplication, and the challenge here is to find all possible ways to do that and end up with only two distances.
Now, you can probably find one very quickly, and possibly another. But Peter said (and I paraphrase) "Nearly everyone misses at least one, and for each possible solution, it's been missed by at least one person."
Well that, of course, put me on guard, and I found all the solutions. But having said that, I found $n-1$ solutions, then started to prove that I had them all, and it was in that process that I found another.
So apparently I now have them all, and you'd think that would be enough. But no, while I had proved that I've got them all, the proof wasn't at all satisfying. It was a lengthy case-by-case analysis, grinding away until it was complete. But I felt there had to be a better way.
You can find Josh's solution on line if you search for it, and you can find how many configurations there are. But I've not seen a simple, clear, clean, incisive proof of the result.
It's not hard to find them all. The proof is the thing.
Josh Jordan took a completely different approach, and that gave me hope that there were other approaches lurking in corners, and perhaps one (or more) would be cleaner, clearer, and more enlightening.
So there you are. It's not enough to find all $n$ solutions, the real challenge is to find a simple proof that you have them all.
I'd love to hear what you try.


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You need to have recent cocoapods version installed on your Mac OS. Current version is 1.6.1. Please refer to cocoapods website for the details.
In the respective targets for your project in the Podfile add the following line if you want to use IBM Tealeaf SDK's release version which needs to be used in your production version of your application.
In the respective targets for your project in the Podfile add the following line if you want to use IBM Tealeaf SDK's release version with version number. Otherwise you will get the beta version that might new feature or fixes which have not been full tested or approved.
Remember you can use only one of pod 'IBMTealeaf' and pod 'IBMTealeafDebug'. Do not use both at the same time.
If you are using Debug version of IBM Tealeaf SDK. i.e. pod 'IBMTealeafDebug' , then you may edit your project's scheme in XCode and add environmental variable EODebugand set its value to 1; also add environmental variable TLF_DEBUG and set its value to 1. This will make the SDK to start writing debug logs to your xcode console window. If and when you want to report issues, the Tealeaf support engineers will ask you for these logs.


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Home » Meteorites, Comets and Asteroids » Holding Fast to an Asteroid
Holding Fast to an Asteroid
Categories: Meteorites, Comets and Asteroids
By Astrobiology Magazine - Sep 28, 2007
This image, captured by the NEAR Shoemaker Spacecraft, shows the inside of a crater on the Asteroid Eros. In addition to low gravity, asteroids might be a difficult place for human and robotic explorers to maneuver due to the fine, granular material at their surface.
Credit: NEAR Project, JHU APL, NASA
Using a tether system devised by MIT researchers, astronauts could one day stroll across the surface of small asteroids, collecting samples and otherwise exploring these rocks in space without floating away. The technology would help astronauts safely study and explore asteroids, performing experiments to determine if these rocks from space contain important precursor molecules for the origin of life.
The ability to visit asteroids could also be invaluable for testing equipment for a mission to Mars by humans. Further, knowing how to tether an asteroid could be helpful if one needs to be towed away from a potential collision course with Earth, says Christopher Carr, a postdoctoral associate in MIT's Department of Earth, Atmospheric and Planetary Sciences.
Carr and Ian Garrick-Bethell, a graduate student in the department, describe their system in an upcoming issue of the journal Acta Astronautica.
Walking on an asteroid is much more difficult than walking on a planet because asteroids have so little gravity. An astronaut who tried to step onto one would likely fly off or hover above the surface.
Now Carr and Garrick-Bethell say that tying a lightweight rope completely around an asteroid could solve that problem. Once the rope was in place, astronauts could attach themselves to it and maneuver or possibly even walk along the surface.
Some scientists believe that asteroids impacts with the early Earth could have delivered important precursor molecules for life. Studying asteroids up close can help astrobiologists determine whether or not this is true. Video: NEAR Shoemaker flyover of Eros.
That would allow an in-depth exploration of the composition and history of asteroids, which could shed light on some of the big questions about our solar system, such as how the planets formed, said Carr.
"This is an innovative approach to a task nobody has spent much time thinking about," said former astronaut Jeffrey Hoffman, an MIT professor of aeronautics and astronautics who sponsored the paper. "NASA has taken a brief look at a human visit to a Near Earth Object, and it may be something we can do long before going to Mars. Clever ideas will be necessary to allow people to do useful work near objects on which you cannot 'land,' but only 'dock.'"
An asteroid's gravity varies depending on its density and size, which can range from a speck of dust to hundreds of kilometers. On an asteroid that has a diameter larger than eight kilometers, an astronaut who jumps will probably come back to the surface, Carr said. But if the asteroid is smaller than that, the astronaut may float away.
Even if an asteroid has enough gravity to keep an astronaut on the surface, it would be difficult to move around or collect samples. "You couldn't touch anything without sending yourself on a new trajectory or spinning yourself around," said Garrick-Bethell, who is the first author of the Acta Astronautica paper.
Some people have suggested that astronauts could bolt themselves directly to the asteroid, but the granular material covering the asteroids could prevent this.
"It would be like trying to bolt yourself to a pile of gravel or sand," Garrick-Bethell said.
NASA's next scheduled visit to an asteroid is the DAWN spacecraft's future rendezvous with Ceres and Vesta. However, DAWN will examine these asteroids from orbit rather than roving about on their surfaces.
The MIT researchers envision deploying their system with an astronaut or a remote-controlled rocket that unwinds a spool of rope while flying around the asteroid. When the craft reaches the starting point, a loop is formed and tightened. Astronauts could then be held to the asteroid using one or more ropes, permitting them to work on the surface.
One unknown is whether the rope would cut into the granular surface of an asteroid, hindering the system's effectiveness. But even if the rope does not allow astronauts to walk on the surface, it could at least give them something to hold onto as they pull themselves along the asteroid without floating away, said Carr.
The Threat of Small Rocks
Life of a Comet Hunter
Two Way Asteroid Trip Takes Off
NEAR Mission
DAWN mission
Astrobio Top 10: NASA's OSIRIS-REx Spacecraft Arrives at Asteroid Bennu
NASA's Newly Arrived OSIRIS-REx Spacecraft Already Discovers Water on Asteroid
(Meteorites, Comets and Asteroids) Most Read
Martian Moon Rock a Meteor?
Earth 424 – NASA's Spitzer Space Telescope Finding
Witnessing a Planet's Birth
Scientist Suggests Comet and Meteorite Impacts Made Life on Earth Possible
Super-Habitable World May Exist Near Earth
Meteorites Brought Water To Earth During the First Two Million Years
New World of Iron Rain
Dwarf Planet Ceres – 'A Game Changer in the Solar System'
First Detection of Sugars in Meteorites Gives Clues to Origin of Life
Based on a MIT news release


Representatives for a number of artists on a purported list of musicians and performers boycotting the state of Florida in the wake of the George Zimmerman verdict said Tuesday that their clients have never heard of or been contacted about the list.
American Urban Radio Networks White House correspondent April Ryan first reported the list -- which includes heavyweights like Justin Timberlake, Jay Z, Kanye West, Alicia Keys, Madonna and more -- on Monday and credited it to "sources close to the Stevie Wonder camp." The Huffington Post linked to Ryan's list and noted at the time that representatives for artists were being contacted. Late Monday night, HuffPost sources revealed that Rihanna was not involved, despite being named. MotherJones received word that the Rolling Stones -- who also appear on the list -- had never heard of such a campaign.
Additional representatives on Tuesday confirmed to HuffPost that other boldface names on the the list were not involved, but declined to identify their clients on the record. Denials reached a critical mass that began to shed serious doubt on the veracity of the list. On Tuesday, Ryan posted an update on her website in which she said that representatives of artists named "are uncomfortable being identified on that list."
A similar list had been posted on Instagram and Facebook in advance of Ryan's posting.
HuffPost reached Ryan by phone on Tuesday afternoon, and she said the list came from "very credible sources" who had provided her with accurate information in the past. Ryan said she had not seen the Instagram or other social media posts in advance of publishing the list or her update.
Ryan said she received the the list from sources who were "in support of Stevie" and that it was sent to her via text message "in the middle of the night." She saw the message later on Monday morning.
I obtained from multiple sources early Monday a list of artists and entertainers who my sources told me had committed to a boycott of Florida following the George Zimmerman acquittal. Since publishing that list I have heard from several representatives of the artists named who say, on behalf of their clients, they are uncomfortable being identified on that list and are seeking additional information.
The Huffington Post has updated the original post on the matter with a prominent link to this page.


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Nearly four years ago, Debra's life changed completely. She had always been an energetic person who lived a full, fast-paced and satisfying life. Then, she was diagnosed with cardiomyopathy and she was no longer able to work or do the things she always loved. Her outlook stayed positive throughout this trial – she just wanted her life to return to normal. Thankfully, in mid-June 2016, Debra received a life-saving heart transplant. There were some complications, however, she is improving daily with the help of an incredible medical team.
For more than 35 years, Debra worked passionately to improve the lives of thousands of children, youth, families and communities in the Greater Pittsburgh area. Helping her family and others has always been a core part of who she is. Mother to Nikia and Daniel, and "Nana" to four grandkids, she has been the bedrock of her family. When not working to help others, many know her as a talented singer and song-writer.
Debra is excited to regain her strength and get back to her life. In order to do this, however, she needs our help. She is facing expensive medical bills that she cannot meet alone. Post-transplant medical expenses, including follow-up medications, medical appointments, lab fees, co-pays and deductibles, can be as much as $1200 a month.
To help with this financial burden, a fundraising campaign in her honor has been established with Help Hope Live, a trusted nonprofit organization that has been providing community-based fundraising guidance to patients and their families for more than 30 years. All donations are tax-deductible to the full extent allowed by law, are held by Help Hope Live in the Mid-Atlantic Heart Transplant Fund, and are administered by Help Hope Live for transplant-related expenses only. To make a donation to this fundraising campaign, click on the Donate Now button.
On behalf of Debra and her family, thank you for the many prayers, cards, and acts of kindness. Debra is immensely grateful. In the future, she plans to pay forward her blessing by continuing to teach, motivate, inspire and help others to experience more love, peace, hope and courage to endure.
Debra continues to improve daily.
Debra continues to make good health progress and is recuperating at home.


text:
Q: A doubt on the algorithm Cross-Track Distance in Java Code I was researching a way to calculate the shortest distance between a coordinated and a straight when I met the Cross-Track Distance. To find the distance, I had to implement the following code:
final int EarthRadius = 6371; //in kilometers
double lon1, lat1, lon2, lat2, lon3, lat3;

double brng13 = bearing(lat1, lon1, lat2, lon2); // in degrees
double brng12 = bearing(lat1, lon1, lat3, lon3); //  in degrees
double dist13 = harvesine(lat1, lon1, lat3, lon3); // in kilometers

double crosstrack = Math.asin(Math.sin(dist13/EarthRadius)*Math.sin(Math.toRadians(brng13 - brng12))) * EarthRadius;

As I'm implementing the code in Java, functions like sine and cosine receive as argument an angle in radians. Therefore, the line of the cross track should be like this:
double crosstrack = Math.asin(Math.sin(Math.toRadians(dist13/EarthRadius))*Math.sin(Math.toRadians(brng13 - brng12))) * EarthRadius;

The problem is that during my research, I found several codes in Java without converting "dist13/EarthRadius" to radians.
What is the correct way? Convert to radians or not?
Edited - Added missing java functions:
public static double haversine(double lat1, double lon1, double lat2, double lon2) {
        double dLat = Math.toRadians(lat2 - lat1);
        double dLon = Math.toRadians(lon2 - lon1);
        lat1 = Math.toRadians(lat1);
        lat2 = Math.toRadians(lat2);

        double a = Math.pow(Math.sin(dLat / 2),2) + Math.pow(Math.sin(dLon / 2),2) * Math.cos(lat1) * Math.cos(lat2);
        double c = 2 * Math.asin(Math.sqrt(a));
        return EarthRadius  * c;
    }
public static double bearing(double lat1, double lon1, double lat2, double lon2){
  double longitude1 = lon1;
  double longitude2 = lon2;
  double latitude1 = Math.toRadians(lat1);
  double latitude2 = Math.toRadians(lat2);
  double longDiff= Math.toRadians(longitude2-longitude1);
  double y= Math.sin(longDiff)*Math.cos(latitude2);
  double x=Math.cos(latitude1)*Math.sin(latitude2)-Math.sin(latitude1)*Math.cos(latitude2)*Math.cos(longDiff);

  return (Math.toDegrees(Math.atan2(y, x))+360)%360;
}

A: Well, after reading some texts on the formula, I got the answer I needed.
In this article (http://www.movable-type.co.uk/scripts/latlong.html), I found the formula's description:
Formula:    dxt = asin( sin(δ13) ⋅ sin(θ13−θ12) ) ⋅ R
where

δ13 is (angular) distance from start point to third point
θ13 is (initial) bearing from start point to third point
θ12 is (initial) bearing from start point to end point
R is the earth's radius

δ13 is the result of "dist13/Earth_Radius".
But this angle is in radians or degrees? After consulting the book Geographical Information Systems and Computer Cartography  in 67-66 pages, I saw that the angular distance is given in radians. That is, you do not need conversion.
Incidentally, the formula "δ13 = dist13/Earth_Radius" is a variation of the formula to find the distance between two points on earth, dist13 = δ13*Earth_Radius.

redpajama_set_name: RedPajamaStackExchange


LG presents it new LG Shine mobile phone (aka. KV4200, LV4200, SV420). The phone has a 2Megapixel camera, an MP3 player,1GB of memory, M-Commerce. it is now as hot as chocolate in earlier time. It is now available in Korea. More pictures below.


As a Chiropractor I work on all types of musculoskeletal injuries, from car accident and work injuries to sports medicine and family wellness. One of the areas of particular focus in my practice though is pregnancy care. You can find my at Utah Spinal Care in Sandy, Utah.
My youth has affected the way that I practice in many ways. In high school I was a runner, a soccer player, and was a 1A state track champion while a sophomore at Dugway High School here in Utah. Assisting my fellow team mates with injuries was one of my first experiences of treating multiple patients. This got me into the sports medicine that I do, and a part of the reason I became a Certified Chiropractic Sports Physician (CCSP).
My life has been more than just health care. I grew up all over because my father was in the military, so I'm an army brat. I spent most of my youth in Germany, and graduated from Heidelberg High School. I served a mission for the LDS Church in England, and I have always loved the beauty of Europe.
As a licensed massage therapist I specialized in prenatal and clinical massage. I graduated from the Utah College of Massage Therapy (UCMT) in 2000, and went on to study pregnancy and infant massage. I studied human biology among other things and graduated from Utah Valley State College (UVSC). My chiropractic education was in Portland Oregon at Western States Chiropractic College (WSCC) where I was involved in the student government and spent some time lobbying congress for the chiropractic profession.
I have always appreciated the out of doors and UWS provided wondrous reminders of it all around me. UWS has a view of two volcanos from campus Mount St. Helens and Mount Hood. While at UWS St. Helens decided to blow off steam a couple of times and we had a great view of it from class.
Through all of this my family has supported me. I am married to the most beautiful woman in the world. Together, she and I have four beautiful daughters and two handsome sons.
What was the date that you created this site?
January 2008 is when I posted my first post to this blog, so it's been running for 21 months now.
I love your website! I especially love the humor page. How did the chiropractors on your site make an association with your page?
People just have something useful to contribute. If you'd like to write something, I'd be happy to look it over and post it with a link back to you if it's good.


text:
Q: Can elements from a System.Collection.Arraylist be compared to see if any of the elements are the same? Basically what the title of the question asks. If I prompt a user their name, then ask the user to enter any 5 numbers, finally storing the responses into an arraylist.
Wscript.StdOut.WriteLine "What is your name"
name = Wscript.StdIn.ReadLine
Wscript.StdOut.WriteLine "Enter any number"
att1 = CInt(WScript.StdIn.ReadLine)
Wscript.StdOut.WriteLine "Enter any number"
att2 = Cint(Wscript.StdIn.ReadLine)
Wscript.StdOut.WriteLine "Enter any number: "
att3 = CInt(Wscript.StdIn.ReadLine)
Wscript.StdOut.WriteLine "Enter any number: "
att4 = CInt(Wscript.StdIn.ReadLine)
Wscript.StdOut.WriteLine "Enter any number: "
att5 = CInt(Wscript.StdIn.ReadLine)

set myNumArray =  CreateObject("System.Collections.Arraylist")

myNumArray.Add att1
myNumArray.Add att2
myNumArray.Add att3
myNumArray.Add att4
myNumArray.Add att5

How could I discover if any of the numbers the user returned are the same.
for example, The user enters 5 numbers: 1, 2, 2, 4, 5.  How can i tell if the user entered the 2 twice?

A: Use a dictionary
Set Arg = WScript.Arguments
set WshShell = createObject("Wscript.Shell")
Set Inp = WScript.Stdin
Set Outp = Wscript.Stdout

    Set Dict = CreateObject("Scripting.Dictionary")
    Do Until Inp.AtEndOfStream
        On Error Resume Next
        Line=Inp.readline
        Dict.Add Line, ""
        If Err.Number <> 0 then
            If LCase(Arg(1)) = "l" then
                Dict.Remove Line
                Dict.Add Line, ""
            End If
        End If
    Loop
    For Each thing in Dict.Keys()
        Outp.writeline thing
    Next

DeDup
filter dedup {f|l}
filter dup {f|l}

Removes duplicate lines in a file keeping either the first or last occurence
f - keeps the first occuring duplicate line
c - keeps the last occuring duplicate line

Example
filter dedup f < "%systemroot%\win.ini"

Filter reads and writes standard in and standard out only. These are only available in a command prompt.
filter <inputfile >outputfile
filter <inputfile | other_command
other_command | filter >outputfile
other_command | filter | other_command

A: Use a dictionary (but properly):
Option Explicit

Dim alInp : Set alInp = CreateObject("System.Collections.ArrayList")
alInp.Add 1
alInp.Add 2
alInp.Add 2
alInp.Add 4
alInp.Add 5

Dim dicInp : Set dicInp = CreateObject("Scripting.Dictionary")
Dim elm
For Each elm In alInp
    dicInp(elm) = dicInp(elm) + 1
Next
Dim key
For Each key In dicInp
    If dicInp(key) > 1 Then WScript.Echo "found", key, dicInp(key), "times"
Next

ouput:
cscript 34890229.vbs
found 2 2 times

Or - look at the current content of the ArrayList by using it .Contains method:
Option Explicit

Dim alInp : Set alInp = CreateObject("System.Collections.ArrayList")
Dim elm
For Each elm In Array(1, 2, 2, 4, 5)
    If alInp.Contains(elm) Then
       WScript.Echo "not again:", elm
    Else
       alInp.Add elm
    End If
Next
WScript.Echo Join(alInp.ToArray())

output:
cscript 34890229-2.vbs
not again: 2
1 2 4 5


text:
Morawski – ).

Znani Morawscy
 Adolf Jan Morawski (1895–1940) – inżynier elektryk, profesor; internowany przez Rosjan
 Aleksander Morawski (1877–1930) – prawnik; wojewoda stanisławowski
 Anna Morawska (1922–1972) – publicystka katolicka
 Antoni Morawski (XVIII w.) – rzeźnik gnieźnieński; pułkownik
 Antoni Morawski (zm. 1887) – generał, dowódca brygady artylerii
 Antoni W. Morawski – profesor nauk technicznych
 Dominik Morawski (ur. 1921) – publicysta, dziennikarz; aktor; działacz społeczny
 Edward Dzierżykraj-Morawski (1892–1961) – dyplomata; senator
 Eugeniusz Morawski-Dąbrowa (1876–1948) – kompozytor; malarz
 Feliks Jan Szczęsny Morawski (1818–1898) – literat, malarz, archeolog
 Feliks Morawski (1861–1929) – lekarz, działacz społeczny
 Franciszek Ignacy de Paula Morawski (1744–1790) – generał-lejtnant, pisarz wojskowy
 Franciszek Morawski (1783–1861) – poeta; generał, minister wojny
 Franciszek Morawski (1847–1906) – stolarz, działacz socjalistyczny
 Franciszek Morawski (1868–1938) – publicysta, poseł sejmu pruskiego
 Ignacy Feliks Morawski (1744–1790) – generał
 Janina Morawska (1897–1970) – literatka
 Jan Morawski (1633–1700) – jezuita, filozof; teolog
 Jan Morawski (1878–1940) – adwokat minister; sędzia Sądu Najwyższego
 Jan Morawski (1867–1929) – generał brygady, topograf
 Jan Nepomucen Morawski (przed 1744 – po 1794) – rzeźnik, powstaniec 1794; oficer; sybirak
 Józef Aleksy Morawski (1791–1855) – prezes Towarzystwa Kredytowego Ziemskiego
 Józef Maria Morawski (1888–1939) – romanista, profesor w Poznaniu
 Józef Agaton Morawski (1893–1969) – legionista; poseł
 Józef Nikodem Morawski (1813–1902) – poseł, członek Izby Panów
 Kajetan Dzierżykraj-Morawski (1892–1973) – ambasador; wiceminister skarbu RP; emigrant
 Kajetan Piotr Morawski (1817–1880) – polityk; poseł
 Karol Morawski (1767–1841) – generał
 Karol Morawski (1877–1960) – lekarz
 Kazimierz Morawski (1929–2012) – dziennikarz; lider ChSS i UChS
 Kazimierz Morawski (1922–2014) – ekonomista; przewodniczący Centralnej Komisji Rewizyjnej PZPR
 Kazimierz Morawski (1852–1925) – filolog klasyczny; rektor UJ; prezes PAU
 Kazimierz Marian Morawski (1884–1944) – historyk; monarchista; masonoznawca
 Leon Andrzej Morawski (1697–1780) – archidiakon gnieźnieński i poznański
 Maciej Morawski (ur. 1929) – dziennikarz, publicysta; działacz emigracyjny, korespondent Rozgłośni Polskiej Radia Wolna Europa
 Magdalena Morawska (1922–1944) – żołnierz Armii Krajowej, uczestniczka powstania warszawskiego
 Maria Barbara Morawska (1921–2007) – działaczka na rzecz praw człowieka
 Maria Morawska (1830–1889) – założycielka urszulanek w Polsce
 Marian Ignacy Morawski (1845–1901) – jezuita; filozof; profesor UJ
 Marian Józef Morawski (1881–1940) – jezuita; pisarz teologiczny
 Mikołaj Morawski (ok. 1743 – 1811) – poseł na Sejm Czteroletni; członek Rady Najwyższej Rządowej Litewskiej
 Piotr Morawski (1976–2009) – himalaista
 Seweryn Morawski (1819–1900) – arcybiskup metropolita lwowski
 Stanisław Morawski (1802–1853) – lekarz; pisarz, pamiętnikarz
 Stanisław Morawski (1901–1983) – leśnik
 Stanisław Morawski (ur. 1924) – funkcjonariusz Ministerstwa Spraw Wewnętrznych PRL
 Stefan Morawski (1921–2004) – filozof; teoretyk sztuki
 Tadeusz Morawski (1821–1888) – działacz społeczny i polityczny w Wielkim Księstwie Poznańskim
 Tadeusz Morawski (ur. 1940) – naukowiec, profesor; autor palindromów
 Tadeusz Leon Morawski (1893–1974) – polityk, poseł w II RP
 Teodor Morawski (1797–1879) – polityk, historyk, minister z 1831
 Teofil Morawski (1793–1854) – minister z 1831
 Witold Dzierżykraj-Morawski (1895–1944) – pułkownik kawalerii WP
 Witold Morawski (1919–1989) – harcerz; powstaniec warszawski
 Zdzisław Morawski (1859–1928) – minister dla Galicji; eseista historyczny
 Zofia Morawska (1904–2010) – działaczka społeczna, uhonorowana Orderem Orła Białego
 Zuzanna Morawska (1848–1922) – pedagog; autorka książek dla dzieci

Polskie nazwiska


Jurgen Klopp is using the international break as a chance to meet up with his best friend David Wagner and give his non-internationals some more match practice.
Klopp knows the Huddersfield manager from his time in Germany, and loaned our young Welsh keeper David Wagner to him in the summer – taking his advice to sign Leicester's Ben Chilwell, too (although this didn't eventually happen).
On Friday, the sides will play a behind closed doors friendly at Melwood, but Liverpool are expected to put out some well known names.
Roberto Firmino and Lucas haven't been selected by Brazil, Alberto Moreno hasn't been chosen by Spain, James Milner's retired for England, Joel Matip isn't interested in trips to Cameroon for the time being – while Danny Ings and Kevin Stewart will also likely feature against the Championship leaders.
Wagner is delighted with the friendly, and told the Echo that it benefits his squad.
"We are in a good situation that we only have three players away with their national teams in (keeper) Danny Ward (Wales), Jon Gorenc Stankovic (Slovenia Under 21s) and Mooy).
"All the others are available to work here, but we will be careful about the schedules – we have one group who have played a lot since the start of the season and one who have played less.
While we're glad some of the fringe players will get a run-out, we're simply petrified of picking up another pointless injury before a key run of fixtures! International breaks are never kind to us in this regard, but we'll have nobody to blame but ourselves if it's our own friendly that causes an issue.


text:
Q: Perl CGI param or Vars, can I filter the list I need to get back a list of either field names, or a hash, but I don't want hidden fields included? Possible?

A: No information about the type a field is will be sent by the browser, so there is no way to do this automatically.
You need to provide the data yourself, possibly as an array or hash in the Perl program.

A: As I understand, you need a list of the fields from the HTML form except 'hidden' form fields.
You can even collect list of this fields manually your from and 'grep' them from the parameter list.
For example:
use CGI;

...

my @hidden_fields = qw/field1 field2 field3/;
my $grep_fields = join '|', @hidden_fields;

...

my @fields = grep { !/\b($grep_fields)\b/ } $query->param();


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text:
California cap and trade survives industry tax challenge
Auctions can proceed in one of the state's signature climate change programs
ARB's winning streak in climate cases continues. A California superior court has rejected a prominent set of industry challenges to the state's cap-and-trade program, upholding a significant element of California's suite of programs to comply with AB 32 and to reduce the state's greenhouse gas emissions back to 1990 levels by 2020. (Opinion here.) The cases were filed by the California Chamber of Commerce and the Pacific Legal Foundation, which charged that the cap-and-trade program was illegal both as an unconstitutional tax and because the program's auction was not authorized by AB 32. (I discussed the court's August tentative partial ruling in this case here, and Ann has discussed the case background here and here).
As he did in his tentative, Judge Frawley concludes that AB 32 gave ARB wide discretion to design a system of emissions reductions that meets the statutory goals, including authority to employ an auction as a reasonable means to allocate allowances. The Court writes that "both the text and structure of AB 32 demonstrate that the Legislature delegated to ARB the choice of distribution methods." This holding isn't really surprising given the very broad discretion the Legislature gave ARB to design a program to meet AB 32's goals. Every case that has challenged ARB's statutory authority under AB 32 has come up short (see, for example, my post here discussing another such case).
The more interesting element of the case involves the constitutional questions concerning whether the auction amounts to a tax. This set of arguments is trickier. The state is making a lot of money off the auction. The auction has raised more than $300 million so far, largely from businesses regulated under the cap, and much of this revenue will initially be loaned to the General Fund. But as I've written before, and as defendants argued, the auction is missing many of the classic hallmarks of a tax. Most strikingly, purchasers at auction get a tradeable commodity at its market value, and no regulated entity is required to participate as a buyer in the auction.
On this issue, the Court held that Proposition 13 is the legal regime that controls, rather than the more recently enacted Prop 26. He also eschewed what might have been the easiest way to dodge the tax conclusion, holding that regardless of the subjective intent of those designing the auction, it qualifies under Prop 13 as having been enacted "for the purpose of increasing revenues," since it will in fact raise revenue for the state. But he nevertheless declined to hold the auction a tax, concluding that it's more akin to a regulatory fee–though an imperfect match for any current category of fee. He cited the fact that those who purchase allowances receive a tradeable right to pollute, and he analogized the purchase of that right to a purchase of a hunting license or a mineral extraction permit. He also relied on the fact that auction prices are determined, at least in part, by market forces, not by government fiat. Having concluded that the auction imposed something akin to a regulatory fee or charge, he applied a modified Sinclair Paint-type analysis and held the fee valid. Interestingly, this analytical approach reinforces the notion that auction revenues must be spent on projects that further AB 32's purposes — an idea that the State has embraced anyway, but that would not necessarily have been legally required had the Court come down another way.*
Plaintiff Pacific Legal Foundation has already sent out an email blast vowing to appeal, so this case is far from over. The longer the cap-and-trade program is in place, however, and the more auctions and private-party trades are conducted, the harder it becomes to imagine what remedy any judge might issue to claw it back.
*UPDATE: I mean to say not legally required by AB 32 and Prop 13 itself. I recognize that other laws have been passed, since AB 32, restricting the use of auction funds to these purposes (including SB 1018 and AB 1532).
Air Resources Board, auction, California cap-and-trade, Climate Change, Morning Star v. Air Resources Board, tax
2 Replies to "California cap and trade survives industry tax challenge"
Damien Schiff says:
I think it worth noting that the court thought the "tax vs. fee" point "a close question." Slip op. at 16.
Pingback: 2014 FRANKLIN TAX FREE CALIFORNIA
About Cara
Cara Horowitz is the co-executive director of the Emmett Institute on Climate Change and the Environment at UCLA School of Law. The Emmett Institute was founded as the f…
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The Centre for Educational and Extra-curricular Activities and the Municipality of Sevnica will organize a research camp Lisca 2018 for students of different study programmes from 9 to 14 July 2018. Venue: Tončkov dom na Lisci, Lisca, Municipality of Sevnica.
It is planned that 35–40 students will participate in the work of the camp. They will be divided into several interdisciplinary research groups. The groups will work on projects in the field of landscape design, agronomy, ethnology, meteorology, astronomy, environmental protection, science, geography, tourism, culture, sociology, sports and innovative pedagogy. Participants will develop ideological proposals on drawing up a new training environment based on the advanced technologies. Innovative space will be designed for teaching students of different age groups, for games, sports events, recreation and leisure, communication, self-knowledge and understanding of peers.
The work of the research camp participants will involve various activities, such as listening to lectures by experts, exploring the environment, work in a research group, preparation of scientific articles, delivery of the final report and presentation of the research group results on the day of project submission. An interdisciplinary approach to working on a project is a unique opportunity for cooperation, learning, gaining experience and communication among participants — pupils of secondary schools, students of colleges, faculties and universities.
The LISCA 2018 Research Camp will work for 6 days. Organizers compensate the costs of accommodation and meals to each participant.
Application for participation can be sent until 15 June 2018 to the camp leader Andreji Tomažin at andreja.tomazin@csod.si or posavje@csod.si. For information please call: 041 282 196.