SALSA team members test a gravity corer designed to collect lake bottom sediment samples up to 20 feet deep.
On Friday, the Subglacial Antarctic Lakes Scientific Access (SALSA) team announced they'd reached Lake Mercer after melting their way through an enormous frozen river with a high-pressure, hot-water drill. The multi-year effort to tap into the subglacial lake—one of approximately 400 scientists have detected across Antarctica—offers a rare opportunity to study the biology and chemistry of the most isolated ecosystems on Earth.
Priscu, along with two other members of the SALSA science team, three drillers, and two marine technicians, flew into the camp located 650 miles from McMurdo station on December 18. The rest of the science team arrived the following day with 8,000 pounds of cargo in tow—some of the final supplies the team required after ice tractors pulled out a million pounds of drilling equipment, makeshift laboratories, and camp structures last December.
According to the latest SALSA blog post, the team began drilling its main borehole on the evening of December 23. (A secondary borehole that acts as a well, its water back-pumped into the main hole after being filtered and sterilized, was started a night earlier, Priscu told Earther.) Things apparently proceeded smoothly, with the team reaching the 54-square-mile lake on the evening of December 26 after drilling to a depth of 3,556 feet (1,084 meters).
Now that the lake is open, the real fun has begun. The SALSA team is deploying a suite of instruments to study the lake, including a CTD (Conductivity, Temperature, Depth) probe that will assess temperature and provide details on the structure of the water column, and a remotely operated vehicle to take similar measurements away from the borehole and capture 4k video. Researchers will collect samples of water and microbial DNA, as well as ice from the top of the lake and sediment from the bottom.
While much of the initial analysis of these samples will be done on-site, the samples and data collected through this endeavor will likely keep scientists busy for years to come.
In addition to possibly discovering life forms that haven't seen the Sun in centuries, subglacial Lake Mercer offers an opportunity to better understand the local hydrology, including how lakes like this one affect the flow of the massive ice streams they're buried beneath. Studying subglacial Lake Mercer's sediments could also help determine whether it, like Lake Whillans located closer to the sea, was once a marine environment, thus filling an important gap in our understanding of Antarctic history, Priscu said.
Glaciologist and SALSA team member Matt Siegfried takes an Antarctic selfie.
Downloading data from a long-term GPS site located on the Whillans ice plain during the SALSA geophysics team's second week in an unsupported field camp.
A caravan of sleds hauls equipment around for the SALSA geophysics team during their third week in an unsupported field camp.
Glaciologist and SALSA team member Matt Siegfried inspects a GPS station located atop Whillans Subglacial Lake.
Baking chocolate butterscotch oatmeal cookies to ring in the New Year at the SALSA drill camp.
For Siegfried, who leads a four-person geophysics team that's spent the last 5+ weeks in the region servicing a long-term GPS array and installing electromagnetic instruments to map subglacial water, being at the SALSA camp has been "extraordinary." The team arrived last week just as the drillers were pulling their hose out of the borehole after breaking through to the lake, Siegfried wrote Earther via satellite internet. Having spent over a month camping out alone on the ice, it's felt like being in a giant city.


text:
Home Uncategorized Facebook told to limit data collection on its users
Facebook told to limit data collection on its users
Facebook has been ordered to limit the amount of information it gathers on its users as the backlash against the social media giant continues.
A German court has ruled that Facebook will need to cut down on collecting user data across different platforms unless customers have given explicit consent.
The ruling from the German competition regulator (FCO) comes after the body declared it believes Facebook took advantage of its market dominance to gather up huge amounts of user data.
How to delete Facebook
What is GDPR? Everything you need to know
How to unblock Facebook with a VPN
Facebook data collection
"In future, Facebook will no longer be allowed to force its users to agree to the practically unrestricted collection and assigning of non-Facebook data to their Facebook user accounts," said FCO president Andreas Mundt.
"The combination of data sources substantially contributed to the fact that Facebook was able to build a unique database for each individual user and thus to gain market power."
The ruling will apply not just on Facebook, but across WhatsApp and Instagram – both of which are owned by the company, and will soon be integrated by Facebook to share messaging services.
The FCO has said that the different platforms can continue to collect data, but this will need to be kept separate from other services unless the user gives their permission.
In a similar vein, Facebook will only be allowed to collate data from third-party websites and link it to a user's account only if they have given consent.
On the company's main site, this could mean that Facebook will need to amend its Like and Share buttons, both of which allow the firm to track a users IP address, web browser type and version, as well as other data that allows Facebook to identify a user personally.
The ruling is only applicable in Germany for now, but with Facebook currently under investigation in several other countries, could influence its future activities across the world.
Failing to abide by the ruling could see Facebook fined up to 10 percent of its annual revenues.
Facebook hit back at the ruling in a blog post, noting that collecting such data allows it to display better targeted ads to its users, as well as making it easier to identify fake and harmful accounts.
"The GDPR specifically empowers data protection regulators – not competition authorities – to determine whether companies have lived up to their responsibilities," it said.
"And data protection regulators certainly have the expertise to make those conclusions."
"The [FCO] order threatens to undermine this, providing different rights to people based on the size of the companies they do business with."
Looking to keep your data private online? Here's the best VPN service of 2019
Apex Legends hits 10 million players in three days – when it took Fortnite a fortnight
Five qualities to look for in a cloud service provider
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redpajama_set_name: RedPajamaCommonCrawl


Today, we decided to head out to West Lake for some dim sum. For those of you unfamiliar, dim sum is a type of Chinese meal where small portions of food are ordered from carts pushed around the restaurants. These dishes can vary from spring rolls to sticky rice to Chinese pastries. It's a really neat way to try out a lot of food and still be full by the end of the meal.
My family and I have been to West Lake multiple times, both for dim sum and dinner service, and we have always been very happy with the consistent quality of the food throughout the years. West Lake serves a plentiful number of authentic Cantonese dishes, ranging from noodles, rice, seafood, and a variety of beef, poultry, and tofu dishes. The service has never been an issue; the staff is always very nice and friendly. The restaurant does get pretty popular sometimes, especially for dinner service or dim sum service on the weekends. Be prepared to wait a bit on occasion. That wait, however, is well worth it to have some great tasting food that will leave you stuffed by the time you head home.
Their menu has an array of Cantonese-style dishes, and there are quite a few that we have tried that are absolutely delicious. Their dim sum dishes are just as good too.
It is a nice, open dining area that has modest decorations on the walls. The back of the restaurant features a number of fish tanks that hold crabs, lobster, and other various fish. It does get a bit noisy when it's crowded though.
The staff are very attentive to come by to remove empty dishes as well as fill up your tea or water, and everyone is very polite as well.
The prices for the dishes are comparable to other Chinese restaurants, but for the amount of food that you get, you really can't go wrong.


text:
Q: angular 2 show/hide router-outlet and redirect to html page I have created a simple application. I have AD windows authentication web api which is on different domain so I have enabled cors. I have created a spike of api and returning 401 when not authorized.

app.service.ts

authenticateUser(): Observable<any> {
        return this.http.get("http://localhost:36655/", { withCredentials: true })
            .map(this.extractData)
            .catch(this.handleError);
    }

app.component.ts

@Component({
    moduleId: module.id,
    selector: 'app-root',
    templateUrl: 'app.component.html',
    styleUrls: ['app.component.css']
})
export class AppComponent {

    constructor(appService: AppService) {
        appService.authenticateUser()
            .subscribe(response => {

                //do something here because its not 401
            },
            error => {
                if (error.indexOf("401") >= 0)
                    console.log("Redirect to contact page")
                else {

                }
            });
    }
}

There are 2 things I am struggling with

*

*how do I hide Router-Outlet (reason is I don't want to show my main page/links)

*I can hide it using [hidden] on the main div but then how do I redirect? because <router-outlet></router-outlet> will be invisible

app.component.html

            Home

Factory

Supplier

Business Area

    <router-outlet></router-outlet>

I have access all or no-access authentication that's why I dont want to show anything. Is there something like
router.navigate('../shared/contact.html')?
Edit 1:

app.component.ts

@Component({
    moduleId: module.id,
    selector: 'app-root',
    templateUrl: 'app.component.html',
    styleUrls: ['app.component.css']
})
export class AppComponent {
    private isAuthenticated: boolean = false;

    constructor(private authService: AuthService) {
        this.authService.authenticateUser()
            .subscribe(response => {
                if (response.status == 200)
                    this.isAuthenticated = true;
            },
            error => {
                if (error.indexOf("401") >= 0)
                    this.isAuthenticated = false;
            });
    }
}

authguard.ts

@Injectable()
export class AuthGuard implements CanActivate {

    private isActive: boolean = true;
    constructor(private authService: AuthService, private router: Router) {
    }

    canActivate(): boolean {
        this.authService.authenticateUser()
            .subscribe(() => {},
            error => {
                if (error.indexOf("401") >= 0) {
                    let link = ['contactus'];
                    this.router.navigate(link);
                    this.isActive = false;
                }
            });
        return this.isActive;
    }
}

auth.service.ts

@Injectable()
export class AuthService {
    constructor(private http: Http) {

    }

    authenticateUser(): Observable<any> {
        return this.http.get("http://localhost:5002/api/v1/authenticate", { withCredentials: true })
            .map(this.extractData)
            .catch(this.handleError);
    }

    private extractData(response: Response) {
        let body = response;
        return body || {};
    }

    private handleError(error: Response) {
        let errMsg: string;
        if (error instanceof Response) {
            errMsg = `${error.status} - ${error.statusText || ''}`;
        } else {
            errMsg = error.toString();
        }
        return Observable.throw(errMsg);
    }
}

app.component.html

            Ethos

Factory

Supplier

Business Area

        <router-outlet></router-outlet>

app.routes.ts

const routes: Routes = [
    {
        path: '', component: HomeComponent, pathMatch: 'full', canActivate: [AuthGuard]
    },
    { path: 'factory', component: FactoryFormComponent, canActivate: [AuthGuard]},
    //...some other
    { path: 'contactus', component: ContactUsComponent }
];

AuthenticateController.cs

public HttpResponseMessage Get()
        {
            return User.Identity.IsAuthenticated ? new HttpResponseMessage(HttpStatusCode.OK) : new HttpResponseMessage(HttpStatusCode.Unauthorized);
        }

I can hide the menu fine but homeComponent which is search textbox renders before authentication, I want to hide everything and just want to show Logo. this search for factory textbox should not be displayed and there is data like gridview at the bottom which i am not showing in this picture.

It does not redirect until Cancel is clicked...another solution is just like I hid the menu I do it on homeComponent but there are many authService calls going around which is not elegant i guess

A: In Angular 2 Routes you have 'CanActivate' and 'CanActivateChild' property.
This can be used for authorization before rendering the component.
You can find the usage here: https://angular.io/docs/ts/latest/guide/router.html#!#can-activate-guard
In your case, you do not have to remove the router-outlet.
Instead:

*

*Add only <router-outlet></router-outlet> in your app.component.html.

*Provide 2 routes

*

*Default route for your main component which requires authorization.

*A separate route(/contact) for your contact component which is linked with the contact.html.
Import RouterModule in app module to add routes.
example:
RouterModule.forRoot([
{
    path: '',
    canActivate: [AuthGuard] //provide the Injectable class here to authenticate.
    component: MainComponent
},
{
    path: 'contact',
    component: ContentComponent
}
])

*Create an @Injectable class as a guard to authenticate the user. This will call the app service to authenticate the user and redirect to contact component if unauthorized.
You can use this.router.navigate(['contact']); import Router from "@angular/router"

*Add this new @Injectable class as the CanActivate property for your default route.

redpajama_set_name: RedPajamaStackExchange


text:
Makeover in Milton Keynes
In celebration of International Women's Day on Friday, the staff at The Body Shop in Milton Keynes offered women supported by MacIntyre the chance to enjoy a makeover and a pamper session.
With so many products to choose from, the women enjoyed a variety of skin care treatments as well as a makeup masterclass.
Lauren, one of the women we support was thrilled and said:
"I loved it. My mum is going to think I'm going to a party!"
Staff at the Body Shop in Milton Keynes also generously donated a 'beauty gift box' as a raffle prize for our upcoming Milton Keynes Fashion Show on 5 April. The Fashion Show will feature a catwalk show and the opportunity to try on and purchase clothes 50% or more off the high street price.
On behalf of everyone at MacIntyre, we'd like to thank Rebecca and Emily at The Body Shop in The Centre MK for all of their kindness and support.
If you would like to find out more about our upcoming Fashion Show, please contact our Fundraising Team via [javascript protected email address] or phone 01908 357012.
More about how we support people in Milton Keynes
The unsung heros and heroines of MacIntyre
Mihaela works in our Staff Support team which manages MacIntyre's payroll function for over 2,000 staff.
Embedding all facilitation skills in daily sessions
Today we would like to introduce you to Donna McHenry, Community Teaching Facilitator from Milton Keynes.
What a glorious feeling!
The team and people we support from Great Holm had the amazing opportunity to watch 'Singin' in the Rain' at Milton Keynes Theatre.
The highs and lows of being a football fan
Michael travels to Liverpool to support his favourite team at their celebration parade.


text:
package com.guyazhou.examples.springboot.oauth2.demo.security;

import com.guyazhou.examples.springboot.oauth2.demo.entity.Authority;
import com.guyazhou.examples.springboot.oauth2.demo.entity.User;
import com.guyazhou.examples.springboot.oauth2.demo.entity.constant.Role;
import com.guyazhou.examples.springboot.oauth2.demo.repository.UserRepository;
import org.slf4j.Logger;
import org.slf4j.LoggerFactory;
import org.springframework.beans.factory.annotation.Autowired;
import org.springframework.security.core.GrantedAuthority;
import org.springframework.security.core.authority.SimpleGrantedAuthority;
import org.springframework.security.core.userdetails.UserDetails;
import org.springframework.security.core.userdetails.UsernameNotFoundException;
import org.springframework.stereotype.Component;

import java.util.ArrayList;
import java.util.Collection;

/**
 *
 * Created by YaZhou.Gu on 2017/6/15.
 */
@Component("userDetailsService")
public class UserDetailsService implements org.springframework.security.core.userdetails.UserDetailsService {

    private static final Logger log = LoggerFactory.getLogger(UserDetailsService.class);

    private final UserRepository userRepository;

    @Autowired
    public UserDetailsService(UserRepository userRepository) {
        this.userRepository = userRepository;
    }

    @Override
    public UserDetails loadUserByUsername(String username) throws UsernameNotFoundException {

        log.debug("Authenticating {}", username);
        String lowercaseLogin = username.toLowerCase();

        User userFromDatabase;
        if(lowercaseLogin.contains("@")) {
            userFromDatabase = userRepository.findByEmail(lowercaseLogin);
        } else {
            userFromDatabase = userRepository.findByUsernameCaseInsensitive(lowercaseLogin);
        }

        if (userFromDatabase == null) {
            throw new UsernameNotFoundException("User " + lowercaseLogin + " was not found in the database");
        } else if (!userFromDatabase.isActivated()) {
            throw new UserNotActivatedException("User " + lowercaseLogin + " is not activated");
        }

        Collection<GrantedAuthority> grantedAuthorities = new ArrayList<>();
        for (Authority authority : userFromDatabase.getAuthorities()) {
            GrantedAuthority grantedAuthority = new SimpleGrantedAuthority(authority.getName());
            grantedAuthorities.add(grantedAuthority);
        }

        return new org.springframework.security.core.userdetails.User(userFromDatabase.getUsername(),
                userFromDatabase.getPassword(), grantedAuthorities);
    }
}

redpajama_set_name: RedPajamaGithub


The Bristol Hotel, a landmark destination. The most contemporary hotel in Gurgaon offers superlative standards of comfort and luxury complemented with a variety of restaurants offering delectable cuisines of the world. Spread over 4 acres of beautiful landscape, strategically located, The Bristol is a 20 minute drive from the Aiport and a minute away from the commercial center of the city. Outstanding service, promising comfort make us a perfect destination for our guests!
The best place to socialise and make your time memorable. To experience a warm & welcoming ambience, to get pampered, try the very exclusive banqueting venues i.e., Victoria, Ball Room, Piccadily, Monarch, Regent, huge lawns, terrace, and poolside garden. The hotel has all of the facilities to host a variety of social events with delicious food and excellent service. Our experienced staff will make sure that every occasion becomes an unforgettable one.
There are currently no reviews for The Bristol Hotel yet.
The Bristol Hotel details have been saved to your shortlist.


text:
The Dawson Car Company was formed in June 1918 by AJ Dawson, previously works manager at Hillman and designer of the 1913 Hillman Nine car and launched in 1919.

The only car made by the company was the 11-12 hp with a water-cooled, four-cylinder 1795 cc overhead camshaft engine coupled to a three-speed gearbox. It was available in four body styles, most bodied by Charlesworth, and unusually, customers could not buy a chassis only. Most were sold in Dawson Blue with black wings. Final production seems to have been in 1921 after about 65 cars were made.

The Dawson cars were expensive, the cheapest being £600 for the two-seater, and could not compete with Morris and Austin.  Nearly all the components were made in-house.

In 1921 the Triumph Cycle Company Ltd. bought Dawson's premises and fittings in Clay Lane, Stoke, Coventry but no more of the 11-12 models were made.

See also
 List of car manufacturers of the United Kingdom

References

Defunct motor vehicle manufacturers of England
Coventry motor companies

redpajama_set_name: RedPajamaWikipedia


Welcome to our Student Council page. We are very excited to be a part of Braswell's first Student Council organization.
A student council a group of student leaders who work with an adult advisor to collaborate with others to impact their school community, with impacts their city or town, which impacts their state, which impacts our country, which changes the world.
Student Council meetings 2nd Tuesday of every month. Students are required to attend the meetings.
Volunteer Hours: STUCO students are required to do 30 hours of volunteer service each semester.


text:
Download The Principles Of Integrated Technology In Avionics Systems Book PDF
Download full The Principles Of Integrated Technology In Avionics Systems books PDF, EPUB, Tuebl, Textbook, Mobi or read online The Principles Of Integrated Technology In Avionics Systems anytime and anywhere on any device. Get free access to the library by create an account, fast download and ads free. We cannot guarantee that every book is in the library.
The Principles of Integrated Technology in Avionics Systems
Author : Guoqing Wang,Wenhao Zhao
Summary : The Principles of Integrated Technology in Avionics Systems describes how integration can improve flight operations, enhance system processing efficiency and equip resource integration. The title provides systematic coverage of avionics system architecture and ground system integration. Looking beyond hardware resource sharing alone, it guides the reader through the benefits and scope of a modern integrated avionics system. Integrated technology enhances the performance of organizations by improving system capacity and boosting efficiency. Avionics systems are the functional center of aircraft systems. System integration technology plays a vital role in the complex world of avionics and an integrated avionics system will fully-address systems, information and processes. Introduces integration technology in complex avionics systems Guides the reader through the scope and benefits of avionic system integration Gives practical guidance on using integration to optimize an avionics system Describes the basis of avionics system architecture and ground system integration Presents modern avionics as a system that is becoming increasingly integrated
Control and Dynamic Systems V52: Integrated Technology Methods and Applications in Aerospace Systems Design
Author : C.T. Leonides
Summary : Control and Dynamic Systems: Advances in Theory and Applications, Volume 52: Integrated Technology Methods and Applications in Aerospace System Design discusses the various techniques and applications in aerospace systems. This book presents automation and integration techniques in optimizing aircraft structural design. It also covers a number of technologies used in aerospace systems such as active flutter suppression, flight control configuration, aeroassisted plane change missions, flight control systems, and impaired aircraft. This book concludes by demonstrating some modeling issues in command, control, and communication networks. This book is a significant reference source for engineers involved in aerospace systems design.
Introduction to Avionics Systems
Author : R.P.G. Collinson
Summary : Introduction to Avionic Systems, Third Edition explains the basic principles and underlying theory of the core avionic systems in modern civil and military aircraft, comprising the pilot's head-up and head-down displays, data entry and control systems, fly by wire flight control systems, inertial sensor and air data systems, navigation systems, autopilots and flight management systems. The implementation and integration of these systems with current (2010) technology is explained together with the methods adopted to meet the very high safety and integrity requirements. The systems are analysed from the physical laws governing their behaviour, so that the system design and response can be understood and the performance examined. Worked examples are given to show how the theory can be applied and an engineering "feel" gained from a simplified model. Physical explanations are also set out and the text is structured so that readers can "fast forward" through the maths, if they so wish. Introduction to Avionic Systems, Third Edition meets the needs of graduates, or equivalent, entering the aerospace industries who have been educated in a wide range of disciplines, for example, electronic engineering, computing science, mathematics, physics, mechanical and aeronautical engineering. It also meets the needs of engineers at all levels working in particular areas of avionics who require an understanding of other avionic systems. Technology is continually advancing and this new third edition has been revised and updated and the presentation improved, where appropriate, The systems coverage has also been increased and a new section on helicopter flight control added.
Scientific and Technical Aerospace Reports
ISBN : UIUC:30112075701448
Civil Avionics Systems
Author : Ian Moir,Allan Seabridge,Malcolm Jukes
Summary : Civil Avionics Systems, Second Edition, is an updated andin-depth practical guide to integrated avionic systems as appliedto civil aircraft and this new edition has been expanded to includethe latest developments in modern avionics. It describes avionicsystems and potential developments in the field to help educatestudents and practitioners in the process of designing, buildingand operating modern aircraft in the contemporary aviationsystem. Integration is a predominant theme of this book, as aircraftsystems are becoming more integrated and complex, but so is theeconomic, political and technical environment in which theyoperate. Key features: • Content is based on many years of practical industrialexperience by the authors on a range of civil and militaryprojects • Generates an understanding of the integration andinterconnectedness of systems in modern complex aircraft • Updated contents in the light of latest applications • Substantial new material has been included in the areas ofavionics technology, software and system safety The authors are all recognised experts in the field and betweenthem have over 140 years' experience in the aircraftindustry. Their direct and accessible style ensures that CivilAvionics Systems, Second Edition is a must-have guide to integratedavionic systems in modern aircraft for those in the aerospaceindustry and academia.
Summary : Introduction to Avionic Systems, Second Edition explains the principles and theory of modern avionic systems and how they are implemented with current technology for both civil and military aircraft. The systems are analysed mathematically, where appropriate, so that the design and performance can be understood. The book covers displays and man-machine interaction, aerodynamics and aircraft control, fly-by-wire flight control, inertial sensors and attitude derivation, navigation systems, air data and air data systems, autopilots and flight management systems, avionic systems integration and unmanned air vehicles. About the Author. Dick Collinson has had "hands-on" experience of most of the systems covered in this book and, as Manager of the Flight Automation Research Laboratory of GEC-Marconi Avionics Ltd. (now part of BAE Systems Ltd.), led the avionics research activities for the company at Rochester, Kent for many years. He was awarded the Silver Medal of the Royal Aeronautical Society in 1989 for his contribution to avionic systems research and development.
Aircraft Systems
Author : Ian Moir,Allan Seabridge
Summary : This third edition of Aircraft Systems represents a timely update of the Aerospace Series' successful and widely acclaimed flagship title. Moir and Seabridge present an in-depth study of the general systems of an aircraft – electronics, hydraulics, pneumatics, emergency systems and flight control to name but a few - that transform an aircraft shell into a living, functioning and communicating flying machine. Advances in systems technology continue to alloy systems and avionics, with aircraft support and flight systems increasingly controlled and monitored by electronics; the authors handle the complexities of these overlaps and interactions in a straightforward and accessible manner that also enhances synergy with the book's two sister volumes, Civil Avionics Systems and Military Avionics Systems. Aircraft Systems, 3rd Edition is thoroughly revised and expanded from the last edition in 2001, reflecting the significant technological and procedural changes that have occurred in the interim – new aircraft types, increased electronic implementation, developing markets, increased environmental pressures and the emergence of UAVs. Every chapter is updated, and the latest technologies depicted. It offers an essential reference tool for aerospace industry researchers and practitioners such as aircraft designers, fuel specialists, engine specialists, and ground crew maintenance providers, as well as a textbook for senior undergraduate and postgraduate students in systems engineering, aerospace and engineering avionics.
Systems, Controls, Embedded Systems, Energy, and Machines
Author : Richard C. Dorf
Summary : In two editions spanning more than a decade, The Electrical Engineering Handbook stands as the definitive reference to the multidisciplinary field of electrical engineering. Our knowledge continues to grow, and so does the Handbook. For the third edition, it has expanded into a set of six books carefully focused on a specialized area or field of study. Each book represents a concise yet definitive collection of key concepts, models, and equations in its respective domain, thoughtfully gathered for convenient access. Systems, Controls, Embedded Systems, Energy, and Machines explores in detail the fields of energy devices, machines, and systems as well as control systems. It provides all of the fundamental concepts needed for thorough, in-depth understanding of each area and devotes special attention to the emerging area of embedded systems. Each article includes defining terms, references, and sources of further information. Encompassing the work of the world's foremost experts in their respective specialties, Systems, Controls, Embedded Systems, Energy, and Machines features the latest developments, the broadest scope of coverage, and new material on human-computer interaction.
Introduction to Aircraft Aeroelasticity and Loads
Author : Jan R. Wright,Jonathan Edward Cooper
Summary : Introduction to Aircraft Aeroelasticity and Loads, SecondEdition is an updated new edition offering comprehensivecoverage of the main principles of aircraft aeroelasticity andloads. For ease of reference, the book is divided into three partsand begins by reviewing the underlying disciplines of vibrations,aerodynamics, loads and control, and then goes on to describesimplified models to illustrate aeroelastic behaviour and aircraftresponse and loads for the flexible aircraft before introducingsome more advanced methodologies. Finally, it explains howindustrial certification requirements for aeroelasticity and loadsmay be met and relates these to the earlier theoretical approachesused. Key features of this new edition include: Uses a unified simple aeroelastic model throughout thebook Major revisions to chapters on aeroelasticity Updates and reorganisation of chapters involving FiniteElements Some reorganisation of loads material Updates on certification requirements Accompanied by a website containing a solutions manual, andMATLAB® and SIMULINK® programs that relate to the modelsused For instructors who recommend this textbook, a series oflecture slides are also available Introduction to Aircraft Aeroelasticity and Loads, SecondEdition is a must-have reference for researchers andpractitioners working in the aeroelasticity and loads fields, andis also an excellent textbook for senior undergraduate and graduatestudents in aerospace engineering.
Theoretical and Computational Aerodynamics
Author : Tapan K. Sengupta
Summary : Aerodynamics has seen many developments due to the growth of scientific computing, which has caused the design cycle time of aerospace vehicles to be heavily reduced. Today computational aerodynamics appears in the preliminary step of a new design, relegating costly, time-consuming wind tunnel testing to the final stages of design. Theoretical and Computational Aerodynamics is aimed to be a comprehensive textbook, covering classical aerodynamic theories and recent applications made possible by computational aerodynamics. It starts with a discussion on lift and drag from an overall dynamical approach, and after stating the governing Navier-Stokes equation, covers potential flows and panel method. Low aspect ratio and delta wings (including vortex breakdown) are also discussed in detail, and after introducing boundary layer theory, computational aerodynamics is covered for DNS and LES. Other topics covered are on flow transition to analyse NLF airfoils, bypass transition, streamwise and cross-flow instability over swept wings, viscous transonic flow over airfoils, low Reynolds number aerodynamics, high lift devices and flow control. Key features: Blends classical theories of incompressible aerodynamics to panel methods Covers lifting surface theories and low aspect ratio wing and wing-body aerodynamics Presents computational aerodynamics from first principles for incompressible and compressible flows Covers unsteady and low Reynolds number aerodynamics Includes an up-to-date account of DNS of airfoil aerodynamics including flow transition for NLF airfoils Contains chapter problems and illustrative examples Accompanied by a website hosting problems and a solution manual Theoretical and Computational Aerodynamics is an ideal textbook for undergraduate and graduate students, and is also aimed to be a useful resource book on aerodynamics for researchers and practitioners in the research labs and the industry.
Principles of Avionics Computer Systems
Author : J. N. Bloom
ISBN : MINN:31951000542128I
Summary : An introduction to fundamentals of digital computers, data acquisition and communication, logical partitioning and optimization of sub-systems is given. A methodology of design is developed by philosophical discussion, detailed description of processes, and by practical examples of the application of basic principles to the problems of system and component design. The technique of specifying a requirement is discussed in detail as are the various steps required to satisfy it. The book provides a helpful background to the non-expert for the acquisition of complex avionic computer-based systems. Where practicable, an extensive bibliography for further reading is provided. This AGARDograph has been prepared at the request of the Avionics Panel of AGARD.
Designing Software-Intensive Systems: Methods and Principles
Author : Tiako, Pierre F.
Summary : "This book addresses the complex issues associated with software engineering environment capabilities for designing real-time embedded software systems"--Provided by publisher.
14th DASC Digital Avionics Systems Conference AIAA/IEEE
IEEE/AIAA Digital Avionics Systems Conference
ISBN : CORNELL:31924077552812
Digital Avionics Handbook
Author : Cary Spitzer,Uma Ferrell,Thomas Ferrell
Summary : A perennial bestseller, the Digital Avionics Handbook offers a comprehensive view of avionics. Complete with case studies of avionics architectures as well as examples of modern systems flying on current military and civil aircraft, this Third Edition includes: Ten brand-new chapters covering new topics and emerging trends Significant restructuring to deliver a more coherent and cohesive story Updates to all existing chapters to reflect the latest software and technologies Featuring discussions of new data bus and display concepts involving retina scanning, speech interaction, and synthetic vision, the Digital Avionics Handbook, Third Edition provides practicing and aspiring electrical, aerospace, avionics, and control systems engineers with a pragmatic look at the present state of the art of avionics.
Government Reports Announcements & Index
ISBN : MINN:31951T002426766
Aircraft Digital Electronic and Computer Systems
Author : Mike Tooley,David Wyatt
Summary : Butterworth-Heinemann's Aircraft Engineering Principles and Practice Series provides students, apprentices and practicing aerospace professionals with the definitive resources to advance their aircraft engineering maintenance studies and career. This book provides an introduction to the principles of aircraft digital and electronic systems. It is written for anyone pursuing a career in aircraft maintenance engineering or a related aerospace engineering discipline, and in particular will be suitable for those studying for licensed aircraft maintenance engineer status as part of an EASA or FAR-147 approved course or taking Aerospace Engineering City and Guilds modules, EDEXCEL National Units, EDEXCEL Higher National Units or a Degree in aircraft engineering.
Space Transportation System Technology Symposium. Volume 6 - Integrated Electronics /including Electric Power/
ISBN : NASA:31769000528383
AIAA Student Journal
Author : American Institute of Aeronautics and Astronautics
ISBN : UCSD:31822015409824
Military Avionics Systems
Author : Ian Moir
Summary : Ian Moir and Allan Seabridge Military avionics is a complex and technically challenging field which requires a high level of competence from all those involved in the aircraft design and maintenance. As the various systems on board an aircraft evolve to become more and more inter-dependent and integrated, it is becoming increasingly important for designers to have a holistic view and knowledge of aircraft systems in order to produce an effective design for their individual components and effectively combine the systems involved. This book introduces the military roles expected of aircraft types and describes the avionics systems required to fulfil these roles. These range from technology and architectures through to navigations systems, sensors, computing architectures and the human-machine interface. It enables students to put together combinations of systems in order to perform specific military roles. Sister volume to the authors' previous successful title 'Civil Avionics Systems' Covers a wide range of military aircraft roles and systems applications Offers clear and concise system descriptions Includes case studies and examples from current projects Features full colour illustrations detailing aircraft display systems Military Avionics Systems will appeal to practitioners in the aerospace industry across many disciplines such as aerospace engineers, designers, pilots, aircrew, maintenance engineers, ground crew, navigation experts, weapons developers and instrumentation developers. It also provides a valuable reference source to students in the fields of systems and aerospace engineering and avionics.
Aircraft Electrical and Electronic Systems
Author : David Wyatt,Mike Tooley
Summary : The Aircraft Engineering Principles and Practice Series provides students, apprentices and practicing aerospace professionals with the definitive resources to take forward their aircraft engineering maintenance studies and career. This book provides a detailed introduction to the principles of aircraft electrical and electronic systems. It delivers the essential principles and knowledge required by certifying mechanics, technicians and engineers engaged in engineering maintenance on commercial aircraft and in general aviation. It is well suited for anyone pursuing a career in aircraft maintenance engineering or a related aerospace engineering discipline, and in particular those studying for licensed aircraft maintenance engineer status. The book systematically covers the avionic content of EASA Part-66 modules 11 and 13 syllabus, and is ideal for anyone studying as part of an EASA and FAR-147 approved course in aerospace engineering. All the necessary mathematical, electrical and electronic principles are explained clearly and in-depth, meeting the requirements of EASA Part-66 modules, City and Guilds Aerospace Engineering modules, BTEC National Units, elements of BTEC Higher National Units, and a Foundation Degree in aircraft maintenance engineering or a related discipline.
Brain Injury Medicine
Biomethane Production from Vegetable and Water Hyacinth Waste
Twentieth-Century World
The Physics of Icebergs
New Health Systems
A Handful of Quiet
The Mushroom at the End of the World
Cryoablation of Cardiac Arrhythmias
Handbook of Medical Image Processing and Analysis
Cognitive Foundations for Improving Mathematical Learning
Platform Interference in Wireless Systems
Anti Bias Education for Young Children and Ourselves
Chemical Projects Scale Up
Minimally Invasive Percutaneous Spinal Techniques
Gas and Oil Reliability Engineering
Majestic Rainbow Bible Tabs
Intelligent Data Sensing and Processing for Health and Well-being Applications


Singapore Airlines is a major air carrier in Asia. Founded in the year 1947, it has been running very successfully and making travel a pleasant experience for its passengers. It has more than 150 aircrafts operating to more than 60 destinations the world over, while maintaining a 5-star ranking. Singapore Airlines is also the first airline to operate the Airbus A380 to the Heathrow Airport in London. Commercial flights are operated by it from Singapore to California, Los Angeles and New Jersey. It has also a plan to include some newer destinations, which include Hong Kong, Beijing, Melbourne and Los Angeles. In the Southern Asian region, it has a strong presence and is one of the major airline companies. It has a subsidiary airline, SilkAir, which connects more international destinations in the Southern Asian region.


Sweet with a bit of zest and tang. I would eat this any time of day!
You can eat this Greek Yogurt with Mango and Sweet Pepper Salsa any time of day really: whip it up for a quick breakfast or fancy brunch for guests; enjoy the protein after a workout or as a snack that won't ruin your fitness; it's savory for lunch and sweet for dessert all at the same time. Greek yogurt is so incredibly versatile. And the sour and sweet flavors here balance so well you can reach for the 0% fat version, add no sugar, and keep it super healthy without sacrificing taste.
Give your mango a gentle squeeze to see if it's ripe. Some mangoes might also smell sweet at the stem end.
Leave the mango big so you can bite into sweet chunks independent of the zesty onion and cilantro. This also helps the flavors keep until the next day. There's no added oil or juices so it won't get soggy if you pack for later.
Simple. Just so right! Enjoy it early and often.
Look it matches my rug! Don't these colors just make you smile?
I found these beautiful sweet peppers in a Sunset brand bag at my local Fairway…and this is what they look like after a week in the fridge.
Mix together mango, peppers, onion and cilantro and season. Season with salt, pepper and/or lime juice, if desired to balance flavors. Spoon 1 cup of yogurt into each bowl and top each with 1/2 cup of salsa. Enjoy immediately or pack for later.
I thought I would need a little honey for the tang of my 0% fat Greek yogurt, but the ripe chunks of mango gave all of the sweetness I needed.
I can't wait until these beauties start to pop up at the farmers market again.


KARS encodes lysyl- transfer ribonucleic acid (tRNA) synthetase, which catalyzes the aminoacylation of tRNA-Lys in the cytoplasm and mitochondria. Eleven families/sporadic patients and 16 different mutations in KARS have been reported to date. The associated clinical phenotype is heterogeneous ranging from early onset encephalopathy to isolated peripheral neuropathy or nonsyndromic hearing impairment. Recently additional presentations including leukoencephalopathy as predominant cerebral involvement or cardiomyopathy, isolated or associated with muscular and cerebral involvement, have been reported. A progressive Leukoencephalopathy with brainstem and spinal cord calcifications was previously described in a singleton patient and in two siblings, without the identification of the genetic cause. We reported here about a new severe phenotype associated with biallelic KARS mutations and sharing some common points with the other already reported phenotypes, but with a distinct clinical and neuroimaging picture. Review of KARS mutant patients published to date will be also discussed.
Herein, we report the clinical, biochemical and molecular findings of 2 unreported Italian patients affected by developmental delay, acquired microcephaly, spastic tetraparesis, epilepsy, sensory-neural hypoacusia, visual impairment, microcytic hypochromic anaemia and signs of hepatic dysfunction. MRI pattern in our patients was characterized by progressive diffuse leukoencephalopathy and calcifications extending in cerebral, brainstem and cerebellar white matter, with spinal cord involvement. Genetic analysis performed on these 2 patients and in one subject previously described with similar MRI pattern revealed the presence of biallelic mutations in KARS in all 3 subjects.
With our report we define the molecular basis of the previously described Leukoencephalopathy with Brainstem and Spinal cord Calcification widening the spectrum of KARS related disorders, particularly in childhood onset disease suggestive for mitochondrial impairment. The review of previous cases does not suggest a strict and univocal genotype/phenotype correlation for this highly heterogeneous entity.
Moreover, our cases confirm the usefulness of search for common brain and spine MR imaging pattern and of broad genetic screening, in syndromes clinically resembling mitochondrial disorders in spite of normal biochemical assay.
KARS encodes lysyl- transfer ribonucleic acid (tRNA) synthetase, which catalyzes the aminoacylation of tRNA-Lys in the cytoplasm and mitochondria . Mitochondrial and cytoplasmic aminoacyl–tRNA synthetases (aaRSs) are encoded by distinct nuclear genes, with the exception of KARS and GARS (glycyl–tRNA synthetase) which are present in both cellular compartments [2, 3].
Mutations in aaRSs genes have been linked to a growing number of neurological and systemic disorders with heterogeneous phenotype. Eleven families/sporadic patients and 18 different mutations in KARS have been reported to date. Phenotype is heterogeneous ranging from early onset encephalopathy [4–7] to isolated peripheral neuropathy  or nonsyndromic hearing impairment . Recently, late onset leukoencephalopathy  and cardiomyopathy [11, 12] have been reported.
A progressive leukoencephalopathy with brainstem and spinal cord calcifications was previously described as a distinct entity in a singleton patient  and in two siblings . We report the clinical, biochemical and molecular findings of 2 unreported patients presenting a similar clinical and radiological picture. Genetic analysis performed on them and in the patient previously described  revealed the presence of biallelic mutations in KARS in all three subjects. Review of KARS mutant patients published to date will also be discussed.
All procedures followed were in accordance with the ethical standards of the responsible committee on human experimentation (institutional and national) and with the Helsinki Declaration of 1975, as revised in 2000. Written informed consent was obtained from all individuals or caregivers.
Genomic DNA was extracted from peripheral blood by standard methods. Whole exome sequencing was performed on DNA from patient A, while patient B and C were analyzed using a targeted next generation sequencing (NGS) custom panel containing genes responsible for mitochondrial disorders (Additional file 1). Variants filtering was performed as previously described . Variants identified by WES were validated by Sanger sequencing and resolved on a 3130xl Genetic Analyzer (Applied Biosystems).
Mitochondrial respiratory chain (MRC) activities of complexes I to IV were measured by spectrophotometric methods in supernatants of 800 × g muscle homogenates or in digitonin treated fibroblasts . The activities were normalized to citrate synthase activity, an index of mitochondrial content in the analyzed specimens.
Patient A, first child of unrelated Italian parents, showed a progressive leukoencephalopathy with spinal cord calcifications, deafness, hypochromic microcytic anemia and has been already described by Orcesi et al. .
The patient is a 7 year old male. The family history was unremarkable. He was born at term after an uneventful pregnancy. He showed normal psychomotor development until 6 months of age when, a few days after a febrile illness, he had seizures and psychomotor regression. He started phenobarbital treatment. In the following months he showed a slow psychomotor improvement: trunk control was recovered, he was able to walk with support at 12 months, and had been seizures free (he stopped drug at 8 months). At 18 months, after another febrile illness, he presented subacute psychomotor regression and seizures. Valproate treatment was initiated.
He was admitted to our institute at 3 years and 10 months of age. Clinical evaluation showed stunted growth, microcephaly (<3rd percentile), marked scoliosis, nystagmus, poor eye contact and response to sounds, absence of spontaneous movements and postural control, spastic tetraparesis with extrapyramidal signs, absence of language. At last follow up, at 7 years of age, neurological conditions were stable; seizures were not reported.
Abdominal ultrasound- performed before Valproate treatment - disclosed hepatomegaly, echocardiogram was normal. Fundus oculi performed at 6 months disclosed bilateral optic atrophy; since 3 years of age, visual evoked potential showed absence of any responses; brainstem auditory evoked potential suggested profound sensorineural hypoacousia, pure tone audiometry was not performed. Serial EEG revealed poor organization of cerebral activity and multifocal abnormalities. MRI was normal at 6 months. A second MRI (1 year and 9 months) revealed diffuse signal abnormalities in deep cerebellar white matter (WM), middle cerebellar peduncles, brainstem and bi-hemispheric WM (Fig. 1a-e). A third MRI (3 years and 10 months), (Fig. 1h-j) disclosed extension of the diffuse signal abnormalities in bi-hemispheric WM, involving the U fibers (Fig. 1i, j). There was also full involvement of the posterior arm of the internal capsules, external capsules, thalami, cerebellar WM, cerebellar peduncles and brainstem (Fig. 1f-i).T2 shine-through effect on DWI was evident in the areas of the T2 signal abnormalities. Bilateral Calcarine cortex had a malacic appearance, with a gliotic hyperintensity on T2 and focal atrophy. Diffuse cerebral atrophy was also documented (Fig. 1f-i). Spectroscopy showed reduction of NAA and lactate in the centrum semiovale.
Cranial CT showed calcifications particularly in the periventricular WM, but also evident in the cerebellar WM, pons, thalami, internal capsules and calcarine cortex (Fig. 2a-c). The last brain MRI and CT examinations (7 years) showed worsening of cerebral and cerebellar atrophy and increased cerebral calcifications.
Spinal MRI disclosed on T2WIslight hyperintensity in the lateral columns of both cervical and dorsal spinal cord (Fig. 2j) and spinal CT disclosed calcifications at C6-T1 level.
Blood routine disclosed microcytic hypochromic anemia and mild elevated transaminase levels since first evaluation before valproate treatment. Galactocerebrosidase, arylsulfatases were normal. Plasma lactate and pyruvate levels were elevated: 2872–3042 μmol/l (n.v. 580–2100) and 171 μmol/l (n.v. 5–145) respectively, normal in CSF. Amino acids, creatine and guanidinoacetate were normal. Genetic screening using NGS panel for Aicardi-Goutieres syndrome was negative. A mitochondrial diseases was suspected, muscle biopsy was not possible because of marked hypotrophy. MRC complexes and pyruvate dehydrogenase (PDH) complex activities resulted normal in fibroblasts; analysis of POLG was negative.
This girl was born at term after normal pregnancy and delivery from healthy unrelated parents. At 2 months of age parents started to suspect hearing impairment and at 6 months bilateral cochleopathy was diagnosed on the basis of a type A tympanogram and brainstem auditory evoked potential.
At 12 months she came to our attention. Neurological evaluation showed spastic tetraplegia and microcephaly; she was able to fixate and track a visual target, but was not able to reach an object; spontaneous movements were poor and non-finalized, postural controls absent. At last follow up, at 18 months of age, neurological conditions were stable.
Cerebral MRI (at 6, 12 and 18 months) showed progressive bilateral diffuse supra e infra-tentorial WM abnormalities with involvement of centrum semiovale, corona radiata, initially sparing U fibers; there was also involvement of the posterior arm of the internal capsules, external capsules, thalami, cerebellar and deep WM and brainstem, while putamina were relatively spared. In particular, in the brainstem we noticed bilateral symmetric hyperintensities in the bulbar pyramids and lateral regions, involvement of the superior cerebellar peduncles and in the arciform fibers of their decussation at the level of the mesencephalon. Both V cranial nerves appeared slightly hyperintense on T2WI. Progressive cerebral calcifications were also evident on CT (Fig. 2d-f), initially involving internal capsules, deep and periventricular WM (at 6 months) and since 12 months dentate nuclei.
Spinal MRI performed at 12 months documented bilateral hyperintensities on T2WI in the cervical and dorsal lateral columns (Fig. 2j) and CT showed calcifications at 12 and 18 months.
Visual evoked potentials was slightly delayed at 12 months and severely abnormal at 18, electroretinogram was normal, fundus oculi showed diffuse mild depigmentation; peripheral nerves conductions were normal; EEG showed poor organization of background activity with fronto-centro-temporal spikes at 12 months, increased at 18 months.
Biochemical exams revealed microcytic hypochromic anaemia with normal iron concentration, high level of plasma lactate (3312 μmol/l) and pyruvate (199 μmol/l) with normal CSF concentration. MRC complexes activities resulted normal in fibroblasts.
Abdominal ultrasound revealed inhomogeneous echogenicity, with nodular aspects, liver function tests showed slight elevation of serum transaminases, with normal synthetic function and no signs of cholestasis. Liver biopsy showed mild portal sclerosis with mild distortion of venous portal vessels, without any significant inflammatory infiltrate; lobular parenchyma demonstrated focal enlarged trabeculae with compression of the peripheral hepatocytes, and preserved reticular network without fibrosis. These findings were suggestive of a vascular disturbance with nodular regenerative hyperplasia (Fig. 3).
Whole exome sequencing was performed on patient A; following a filtering strategy that enriched for rare (MAF of < 1%) nonsynonymous/splice variants that segregated in a recessive manner, a short list of candidate genes was obtained but without any known gene associated with WM disease (Additional file 2). Independently, NGS-based screening of genes associated with mitochondrial disorders performed on patient B disclosed two heterozygous variants in KARS (NM_001130089.1): c.1124A > G/p.Tyr375Cys and c.381C > G/p.Phe127Leu. These variants and their segregation in the family were confirmed by Sanger sequencing.
Given the striking similarities of clinical and neuroimaging features between patient B and patient A, WES data from the latter were reconsidered and a likely causative role was assigned to the homozygous variant c.1514G > A/p.Arg505His in KARS. Similarly, because of her clinical presentation an NGS-based screening of KARS was performed on patient C, leading to the identification of two heterozygous variants: c.815 T > G/p.Phe272Cys and c.1043G > A/p.Arg348His. All the identified KARS variants had an extremely low frequency in public databases (< 0.01%), are predicted to be deleterious and hit phylogenetically conserved amino acid residues, supporting their causative role (Additional file 3). Notably, the c.1514G > A/p.Arg505His found in patient A has been recently reported in compound heterozygosity with another missense change in two siblings with early-onset hearing loss and leukoencephalopathy and its pathogenicity has been experimentally proven .
Mutations in different aaRSs have been associated with an increasing number of phenotypes [2, 3]. Encephalopathy is the most common phenotype, but other extra neurological symptoms have been reported: sideroblastic anemia (YARS2 [17, 18]), cardiomyopathy and myopathy (YARS2 , GARS , KARS [11, 12], tubulopathy (SARS2 ), ovarian failure (AARS2 , HARS2 , LARS2 ), hepatopathy (FARS2 , EARS2 ) and hearing loss (HARS2 , LARS2 , KARS ).
Up to now, 11 families/sporadic patients and 18 mutations in KARS have been reported (Tables 1 and 2).
KARS impairment was first linked to peripheral neuropathy  in one patient (Pt 1) presenting with Charcot-Marie-Tooth neuropathy, developmental delay, self-abusive behavior, dysmorphic features, and vestibular Schwannoma. Compound heterozygous p.Leu133His and p.Tyr173SerfsX7 variants were identified. Functional analyses revealed that these two mutations severely affect enzyme activity.
Autosomal recessive nonsyndromic hearing loss was the second phenotype reported . In affected individuals homozygosity for missense mutations (p.Asp377Asn or p.Tyr173His) in KARS was identified. (Pts 2–14/Fam. 2–4). Both variants were predicted to be damaging by multiple bioinformatics tools. The first case of KARS mutations associated with suspected mitochondrial disease was reported in 2013 . The authors analyzed by exome sequencing a series of 102 patients with clinical and biochemical findings suggestive for mitochondrial disorders and identified compound heterozygous KARS mutations (p.Thr587Met; p.Pro228Leu) in a patient affected by psychomotor delay, hearing loss, ophthalmoplegia, dystonia and elevated CSF lactate level (Pt 15/Fam. 5). MRC activity on tissue was not investigated. No experimental proof was reported but, given the predicted severity of the mutations at highly conserved residues, the authors concluded that the observed mutations were likely the genetic cause of patient's phenotype.
A more severe phenotype was reported in two 2 siblings (Pts 16–17/Fam. 6) with early onset visual impairment, progressive microcephaly, developmental delay, seizures and very subtle deep white matter loss on MRI . The patients harbored compound heterozygous mutations (p.Arg466Trp; p.Glu553Lys) within a highly conserved region of the catalytic domain. A similar clinical presentation was reported in a patient who harbored a p.Ala57Pro missense change and a 7601-base pair deletion, encompassing the first three exons of the mitochondrial isoform of KARS (Pt 18/Fam. 7) . Cardiac involvement associated with a deficiency of MRC complexes I and IV has been reported in two patients (Pts 19–20/Fam. 8–9), who carried novel biallelic KARS mutations [11, 12]. The first one presented a childhood-onset hypertrophic cardiomyopathy associated with seizures, developmental delay, in a patient harboring compound heterozygous p.Val476Asp and p.Ile346Thr mutations  while hypertrophic cardiomyopathy was the clinical hallmark in the second, a 14 years old patient with mild myopathic signs and cognitive disability (in spite of normal brain MRI) associated with p.Leu378His and p.Pro418Arg . In both patients lactic acidosis was detected. In the first case, the mitochondrial enzyme defects were rescued by cDNA complementation with mitochondrial KARS, but not cytosolic form . More recently, two mutations (p.Arg505His; p.Pro533Ser) have been reported in two siblings affected by early onset hearing loss, progressive cognitive impairment and psychiatric symptoms with onset in adulthood associated with leukoencephalopathy: brain MRI showed symmetrical confluent abnormalities in the frontal, periventricular white matter and in the corpus callosum . Functional studies showed that both mutations decreased tRNA aminoacylation while p.Arg505His changed the secondary structure of KARS, leading to protein aggregation. Finally, KARS mutations (p.Ala526Val; p.Phe489Cys) were reported in two sisters affected by developmental delay, microcephaly, seizures, and sensorineural hearing loss; calcifications of left occipitoparietal junction were reported in one case (Pt 23). MRC enzymes activity in muscle biopsy was normal, lactate level was not available (Pt 24) .
In the present manuscript we reported about a new severe phenotype associated with biallelic KARS mutations. Our patients presented an early onset and progressive encephalopathy characterized by acquired microcephaly, developmental delay, spastic tetraparesis, epilepsy, sensorineural hypoacusia, visual impairment, microcytic hypochromic anaemia and failure to thrive. In addition patients B and C presented liver involvement. To our knowledge, this is the first report of hepatic involvement in this disease but the exact meaning of the reported anomalies has still to be understood. Nevertheless, in patient A no evidence of liver dysfunction was reported and liver ultrasound was normal.
In patient B, the severity of the phenotype, the clinical onset related to febrile illness and the presence of lactic acidosis suggested a mitochondrial disease that was directly investigated in spite of normal MRC and PDH activities in fibroblasts.
In patient C, clinical picture and lactic acidosis claimed the idea of a mitochondrial disorder as already suggested also in patient A, supported by mild lactate elevation at spectroscopy study. In KARS-mutant cases reported to date, mitochondrial disease was suspected and confirmed by biochemical diagnosis only in patients with cardiomyopathy (Pt 19 and Pt 20); elevated lactate level in CSF was detected in Pt 15 but biochemical studies on tissue were not performed. In other cases, metabolic analyses for mitochondrial disease were unremarkable or not performed. In 5 of 26 KARS patients reported to date, including our cases, both lactate level and biochemical studies (in different tissues) were performed and only in patients with cardiac involvement elevated lactate level corresponded to reduced MRC activity. Nevertheless the lack and heterogeneity of laboratory data does not permitted this phenotypic variability explanation. The MRI findings were similar in all three patients and characterized by progressive diffuse leukoencephalopathy and calcifications extending in cerebral, brainstem and cerebellar WM, with spinal cord involvement. Specifically, at the early stages of the disease the signal abnormalities were observed in the deep cerebellar WM and in the centrum semiovale. Progressively, an extensive diffuse WM involvement, including U fibers, posterior arm of the internal capsules, external capsules, thalami, cerebellar peduncles and brainstem, with selective bilateral symmetric involvement of the bulbar pyramids and lateral bulbar regions resembling the pattern of mitochondrial diseases were observed. The supratentorial WM involvement was characterized by uniform slight hyperintensity on T2WI, interrupted by marked foci of hypointensities due to calcifications. This appearance seems to be due to a demyelinating process an assumption supported also by the evidence of demyelination of the proximal intracisternal portion of the V cranial nerves (Fig. 1g).
Cerebral calcifications have a distinct pattern with initial involvement of deep cerebellar and cerebral periventricular WM and progressive extension to the thalami and internal capsules, in which a peculiar "boomerang appearance" was present. Calcifications were evident even in the initial phases of the disease and might not be a dystrophic epiphenomenon and so a secondary and aspecific event, but an intrinsic feature of the disorder. In the spine they were present in all 3 patients, even if with different severity, and were characterized by a peculiar bilateral and symmetrical distribution in the anterior horns, both extensively (Patient A) or spot-like (Patients B and C). On MRI, bilateral abnormal signal intensity in the lateral columns was also associated.
Patient B dysplayed a more severe cerebral atrophy and grey matter involvement (basal ganglia and cortex) but he underwent the first MRI later in life compared to the other two. As disease progressed, the radiological picture evolved toward a progressive cerebral atrophy in 2 patients (A and B).
WM involvement has been previously reported in few KARS-mutant patients but with a less severe pattern and restricted to supratentorial regions (Pt 16, Pt 17, Pt 21, Pt 22). It is interesting to note that the presence of cerebral WM and spinal cord signal abnormalities is a pretty rare association of neuroradiological features and it is typically observed in other aaRSs deficiencies, notably in DARS and DARS2 related leukodystrophies [27, 28]. It is also a quite common finding in Iron-sulfur cluster related leukoencephalopathies, particularly those caused by GLRX5 , ISCA2 , or IBA57  mutations. The association of cerebral WM abnormalities with spinal cord involvement should prompt to consider aaRSs-related diseases and particularly KARS mutations when calcifications are observed.
The extremely heterogeneous clinical presentation associated with KARS mutations is peculiar in the field of aaRS-related diseases which are usually characterized by strict genotype-phenotype associations, although a definite explanation of the molecular mechanisms underpinning this observation is still missing. Few examples of different phenotypes caused by mutations in the same aaRS gene have been reported (e.g. AARS2 associated with either cardiomyopathy or leukoencephalopathy and ovarian failure [22, 32]). Differences in mode of inheritance and type of mutation cannot easily explain the variable clinical presentations since all the reported cases showed an autosomal recessive transmission of missense mutations. Only the patient described by Joshi et al. (Pt 18/Fam. 7) carried a large deletion, acting as a null allele, together with a missense mutation which disrupts the mitochondrial targeting signal, thus potentially affecting solely the mitochondrial isoform of KARS. All the other patients, irrespective of any evidence of mitochondrial dysfunction, harbored KARS variants which are predicted to strike both mitochondrial and cytosolic KARS isoforms. An effect of the affected functional domains was initially suggested, since the first mutations responsible for the neuropathic phenotype hit the anticodon domain whereas hearing loss associated mutations could be in the catalytic domain. However this hypothesis was not confirmed in the following reports and in the present review of all the KARS mutant patients. For instance, the mutations found in our patients, with an overlapping phenotype, are scattered throughout the gene (from amino acid 127 to 505) and affect either the anticodon-binding or the catalytic domain. The few functional studies which have been performed indicated that various functions/properties of KARS (e.g. tRNA aminoacylation, secondary structure) may be affected by different mutations. Nevertheless, no genotype/phenotype correlation was evident, even considering the residual enzymatic activity of the different mutant forms. Nevertheless a mutation specific effect cannot be excluded, since all the identified KARS mutations were reported in single cases/families; for instance, the cardiac phenotype in AARS2 mutant patients seems to be strictly linked to the presence of a specific amino acid change. The only KARS mutation presents in two unrelated families was the p.Arg505His, identified in homozygosity in patient A and in compound heterozygosity with p.Pro533Ser in Pts 21–22; all these three individuals were characterized by leukodystrophy and hearing problems but the MRI features were not identical and other clinical symptoms were different (e.g. visual impairment and spastic tetraparesis were observed in patient A but not in the two siblings). Obviously, the partially different genotype may account for the phenotype diversities.
With our report we define the molecular basis of the previously described Leukoencephalopathy with Brainstem and Spinal cord Calcification, that we propose to call LBSC similarly to DARS and DARS2 related leukodystrophies, widening the spectrum of KARS related disorders, particularly in childhood onset disease suggestive for mitochondrial impairment. The review of previous cases does not suggest a strict and univocal genotype/phenotype correlation for this highly heterogeneous entity.
This work was supported by the Pierfranco and Luisa Mariani Foundation, the Telethon Grant GGP15041.
AA, LC, DG conceived the study and participated in its design and coordination; AA made a review of literature, wrote the first draft which was completed and implemented by DT, SO, LC, DG; RB, BG critically revised the manuscript for important intellectual content; AA, DT, RB, IM, SO performed the clinical examinations and diagnosis of the patients; GN, MM performed hepatological studies; LF, AP, LC performed acquisition and interpretation of radiological data; AL, EL, BG, DG, ID, OBT performed genetic and biochemical studies and analysed the results. All authors read the final manuscript and approved the final manuscript.
Informed consent for genetic and biochemical studies was obtained from patients' parents, in agreement with the Declaration of Helsinki and approved by the Ethical Committees of the Neurological Institute "Besta" and Neurological Institute "Mondino".
Parents pf pt. A, B and C have given their oral consent to have theclinical data of their sibs published in an anonymized form.


My first pico-8 game, for jam #2. It's a shmup inspired by Ikaruga and Everyday Shooter. If you play, post your high score!
You can shoot an explosion with the opposite color to slow it down and make it stay around longer. The idea is to make it possible to set off a chain and then try to keep explosions worth more points around a bit longer to keep a chain worth a lot of points going.
I just fallen off my chair because of the death sound!
Ahem, it's an interesting concept, and a fun game to play, maybe less flashy graphics would be nice!
I like this game - neat game mechanics! I bet this would be fun coop / dm!
Very cool concept! Deserves to be juiced more though!!


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TEHRAN, December 11 - An international cultural and food festival was held at Pakistan's National Defense University (NDU) in Islamabad with active participation of Iran.
TEHRAN, Young Journalists Club (YJC) - The festival provided an opportunity to the participating countries to share taste of their respective cultures and food with each other.
The festival was attended by Iran, Saudi Arabia, China, Brazil, Jordan, Libya, Lebanon, Malaysia, Nepal, Nigeria, Oman, Sri Lanka, Turkmenistan, Uzbekistan, England, Zimbabwe, Germany, Bangladesh and Egypt.
The participating countries tried to attract local visitors from different countries by promoting traditional cuisine, souvenirs, handicrafts and traditional clothing.
The Iranian stall which was organized by the embassy of Iran presented traditional Iranian food and handicrafts in which the visitors took keen interest.
According to the visitors, the cultural festival was a good way to learn about the cultures and traditions of different countries.


text: require 'coolsms'


…a clinical and holistic nutritionist dedicated to helping individuals use food as medicine to heal from the root cause. I can help you ignite the natural healing process of your mind, body, and spirit so that you can feel whole again.
My passion is helping people live their best life, with a focus on the role nutrition plays in overall wellbeing. I'm the author of The Whole Journey Food as Medicine Cookbook & Healthy Life Handbook, co-author of The Anti-Inflammatory Diet with Cheryl Tiegs, and co-author of the best-seller How to Conceive Naturally and Have a Healthy Pregnancy After 30. I also host three health and wellness TV shows.
I believe that many people suffer needlessly because of a broken healthcare system that places too much emphasis on symptoms, rather than the root cause of an illness. It's been my experience that by viewing the body as a whole, integrated system, where every organ and gland work in concert with each other, anyone can help their body heal itself more effectively – especially when supported by a well-trained clinician.
Every individual is different, with unique dietary needs based upon their genetics, lifestyle, age, stress levels, childhood diet, pharmaceutical history, and current state of health. Understanding those differences is a key element of The Whole Journey's approach.
While most nutritional practices dwell on calories, carbs, fats, proteins and restrictive "good and bad" foods, The Whole Journey philosophy provides you with easy-to-use tools to address the primary reason most people fail to thrive. We educate and empower in a way that is flexible and fun, without relying on willpower or self-denial. The result? A healthier life that's achievable, sustainable, and enjoyable.
Our focus works because it is holistic and accounts for all of you. Not just healthy food, but healthy relationships, healthy movement, a meaningful spiritual practice, an inspiring creative outlet, and an understanding that there can be emotional roots to physical illness.
We don't mask your problems. We address them. If you have a rock in your shoe, is it better to take off your shoe and remove the rock, or take painkillers to mask the discomfort?
By creating a balance between the clinical aspects of health, primary foods, and the foods you eat everyday; you'll experience steady changes in your health and wellbeing that you'll be able to maintain for life.
I'm a 100% Italian, Jersey girl, with no shortage of passion and zest for life. Lucky for me, I discovered my passion for holistic healing in 2003 while taking a year off to backpack around the world.
I was an early caffeine and sugar junkie raised on pizza, pasta, and antibiotics. A bloated, constipated insomniac with no energy and alternating anxiety and depression, and there was also 15 lbs I just couldn't shake – which is a lot on my 5' 5" frame.
What was the root of all of these symptoms?
It was raging Candida, a leaky gut from extensive antibiotic use, and the brewing thyroid and adrenal imbalance I wouldn't discover for another 8 years. Yet I thought I was "normal" because I was "healthy" by my doctors standards; so I pressed on.
After earning a degree in business from the University of North Carolina at Wilmington, I worked in International Relations for a few years, which inspired me to enroll in graduate school and pursue International Peace and Conflict Resolution. While awaiting my acceptance to grad school, I decided to pursue a real world education and hit the road to explore our beautiful planet.
This is when my education really began.
A bit of a hippy in college, I wanted to join the Peace Corps. I thought money was evil. All I wanted to do was make a difference in the world. But how?
Three weeks later, in a tiny South African town, the owner of a local health food store took me to a life-defining workshop called "Optimal Nutrition for The Mind" led by Patrick Holford of the Brain Bio Centre in the UK. Holford described the power of nutrition to transform lives. I was blown away by how much power and control we have over our full experience of life, influenced mostly by how we choose to address and maintain our physical health.
I put this new knowledge to the test and got off all sugar, caffeine, and refined foods. I limited my alcohol consumption and added in key nutrients specifically for my brain, nervous system, and later my digestive system. I fell in love with yoga, and worked out 5 days a week with joy. Because of an inextinguishable spark of inspiration I acted upon, my life completely transformed from the inside out.
For the first time in my life, I experienced energy all day long, enthusiasm for the little things, a profound sense of peace no matter what was happening around me, great digestion, deep sleep, and I finally lost those pesky 15 lbs, boosting my confidence. I couldn't have imagined what true health really felt like – I wanted to share it with everyone I knew…including you.
I chose to enroll in the Institute for Integrative Nutrition to become a Holistic Health Counselor, certified by the American Association of Drugless Practitioners. At the same time, I also attended the Natural Healing Institute for Clinical Nutrition and later did additional coursework in microbiology and advanced biochemistry.
For 8 years I had a by-referral-only practice with a 6-month wait list and worked with 1000+ individuals to help them heal and thrive in a lasting way. We worked on anything from simple life changes, adrenal and thyroid disorders, autoimmune disease to Candida to chronic digestive disorders.
I started to struggle with the guilt that I couldn't accept all the clients that were referred to me. So in 2012, I made the difficult decision to leave private practice to help more people than was possible in a one-on-one setting.
I also wanted to make a greater contribution to the state of health care and become a voice for protecting and improving the food supply.
That led me to create a weekly TV series on FOX, called Food as Medicine, where I take complicated health topics and break them down in ways that are fun, motivating, and easy to understand. Later, I started the nationally syndicated Randy and Christa Show: News that Makes You Healthier and most recently, I have started my own online show called Food as Medicine TV.
I've also had the honor of sharing my work as a guest at TEDX, The Doctors, The Real, SHAPE, NY Post, Redbook, and ESPN.
I set out to create safe, effective, and affordable online programs utilizing the proven strategies I've developed over the last decade to help people truly get out of sickness and into thriving.
Our programs include the Nutritional Lifestyle Program, Kick Candida for Good, and Gut Thrive in 5, the highly-rated gut microbiome program that's helped thousands of men and women reset their digestive system and end years – sometimes decades of suffering.
At first I was resistant to taking my business online because I was so turned off by internet marketing and the constant selling that marketers seem to do. It just felt like inauthentic trickery to me.
I quickly realized though that I could actually use the internet for good. Now, having helped over 15,000 individuals truly change and improve their lives with our paid programs, and millions more with our free content, I realize I made the right choice. It would have taken me several lifetimes to help the same number of people working one-on-one.
I'm sharing this with you because my highest goal is to contribute to your wellbeing and to serve you in the way you need to be served to benefit in a lasting way. To guide you, protect you, and to help you advance your life to a higher level.
I encourage you to join our thriving community of over 130,000 subscribers who are also on a crusade to #feelwholeagain. I only stop by your inbox on Tuesdays to share my Food as Medicine episodes and best health, wellness, and personal insights I don't share anywhere else online.
With love and respect for your journey.


text:
Zeng Yanfen ex SNH48 Sues STAR48 Subject to Contract
Former SNH48 idol group member Zeng Yanfen has filed a lawsuit against the authorities against STAR48. She demanded STAR48 regarding the contract of SNH48 member she wanted to end.
Please note that Zeng Yanfen has been out of SNH48 since November 2017 because she feels pressured by her activities in the group. Since then the girl who is often called Ruri is issued a controversial chirp about SNH48 through personal accounts both Twitter and Weibo.
Zeng Yanfen officially filed a lawsuit on June 11, 2018 through a state high court in the Hongkou District of Shanghai. The trial will be held on June 22, 2018. If there are no obstacles, both parties will certainly attend the hearing.
Ruri is a member of SNH48's second generation incorporated in the original Team NII formation. She was born from a simple family that never gave up. She always forbids her fans to buy gift for her.
Sometimes when the theater is because the penstick that discarded fans, Ruri also asked them to maintain cleanliness in the future. She is also very good to her own fans and other members. Yanfen is one of the popular members of SNH48 which is proven to be often listed as a single senbatsu list.


text:
export * from './app.module';
export * from './app.constants';


A BlueID Operator manages a set of Mobile Devices, Secured Objects and BlueID Tokens. For instance, he can create BlueID Tokens for a Mobile Device in order to grant the Mobile Device access to a Secured Object. The Mobile Device and the Secured Object must belong to the same BlueID Operator.
BlueID Tokens are the digital keys used to execute a command (e.g. "tokn") at an object such as a door or a car. These tokens are digitally signed by the BlueID Trust Center.
The BlueID TokenCard shall be deemed as BlueID Mobile Device. Each BlueID Mobile Device as well as each BlueID TokenCard is assigned to the BlueID Operator Account of the BlueID Trusted Service. The BlueID Trusted Service can issue BlueID Tokens for a BlueID Mobile Device.
The BlueID Trust Center (functioning as a central database) generates digital access authorizations, the so-called BlueID Tokens. Generating a token can be compared to cutting a conventional key. In other words, the Trust Center generates digital keys for the user.
With the term BlueID Trusted Service all micro services are summarized that run as a BlueID Trust Center.
A Lock Server is the software part that runs on the control unit of a Secured Object.
The Mobile Device, i.e. a smartphone, BlueID TokenCard or tablet PC, uses a customer-specific smartphone app which receives the electronic access authorization data (BlueID Tokens), thus enabling access to the associated Secured Objects. The BlueID Operator can integrate the precise access functionality required in every app. The Mobile Device therefore corresponds to a digital keychain which can be used to hold many different types of keys with different functions. These digital keys are then used to access Secured Objects.
The Secured Object contains a customer-specific control unit which interprets the control commands sent by a smartphone and triggers the corresponding functions. The control unit therefore corresponds to the lock for a digital key and enables access to the Secured Object, e.g. a vehicle or a barrier.
from Wikipedia: Service Provider Interface (SPI) is an API intended to be implemented or extended by a third party. It can be used to enable framework extensions and replaceable components.


LONDON - The Duke and Duchess of Sussex have released a statement saying that they will announce the birth of their baby once they have ''celebrated privately as a new family''. The Duke and Duchess of Sussex will announce the birth of their baby once they have ''celebrated privately as a new family''.
The royal couple - who are expecting their first child within weeks - recently moved into their new house in Windsor, Frogmore Cottage, where they will raise their child.
Prince Harry , 34, and Duchess Meghan, 37, have now released a statement insisting that they have made a ''personal decision'' to keep the ''arrival'' of their baby ''private''.
The statement released from Kensington Palace read: ''The Duke and Duchess of Sussex are very grateful for the goodwill they have received from people throughout the United Kingdom and around the world as they prepare to welcome their baby.
This news comes after speculation that Meghan - who was known as Meghan Markle when she worked as an actress before marrying the British prince - maybe planning a midwife-led home birth at the Berkshire estate.
The plans are a break from recent royal tradition which saw the Duke and Duchess of Cambridge - Harry's brother and sister-in-law - welcome their three children, Prince George, five, Princess Charlotte, three, and 12-month-old Prince Louis, at the Lindo Wing, which is the private maternity ward at St Mary's Hospital in Paddington, London. The Lindo Wing is also where the late Princess Diana and Prince Charles had both Prince William and Harry in 1982 and 1984.


During his 17 years long career, his work has been recognized by major local and international awards shows.
He started his career as a copywriter at BBDO. In 2002, he joined Leo Burnett Budapest, where he was promoted to Creative Director in 2008.
He contributed to the creation of "Best Hungarian Campaign of the Decade" which has also won a Cannes Lion.
Since 2014, he is Executive Creative Director of Publicis One Hungary, responsible for the Leo Burnett and Publicis agency brands.
He believes that strategy and technology-based creativity can help brands face the biggest challenge of our time: how to become and remain true to a meaningful purpose.