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As it happened: Victoria records one new COVID-19 case as NSW flags reopening of border with state within a month; Australian death toll stands at 905
Our live coverage of the coronavirus pandemic is free for all registered readers. Please also consider supporting our journalism with a subscription.
By Rachael Dexter and Simone Fox Koob
Updated October 20, 2020 — 8.30pm first published at 7.09am
Victoria recorded one new case on Tuesday and no deaths. The single case could be removed from the tally as the Health Department is investigating whether it is an active case or the person is "shedding" the virus from a previous infection.
NSW has recorded two new locally acquired COVID-19 cases and three cases in hotel quarantine, as the state government flags relaxing rules for places of worship.
The Andrews government is examining scaling back the botched hotel quarantine program and using electronic monitoring devices for some returned travellers when Victoria opens up to international flights.
The border between Victoria and NSW could open within a month if case numbers in Victoria remained low, NSW Premier Gladys Berejiklian has said.
Queensland has recorded another day with zero cases.
Posts area
8.30pm on Oct 20, 2020
Day in review
By Rachael Dexter
That brings us to the end of another day of live coronavirus news. As always, our rolling coverage will be back early tomorrow morning.
What were the main stories around the country today?
Victoria recorded one new case on Tuesday and no deaths. The single death may be removed from the tally as investigations continue into whether it is an active case or the person is "shedding" the virus from a previous infection. A second case was reclassified as it related to a person with a Victorian address who is quarantining interstate. The Premier flagged further easing of restrictions this weekend, depending on this week's numbers.
Meanwhile, Victoria's hotel quarantine inquiry has demanded more statements from key players, including Chief Health Officer Brett Sutton, as new information threatens to "unsettle" the due date for the final report into the bungled program.
And up to 1250 people will be allowed to attend Moonee Valley racecourse on Saturday for the 100th anniversary of the Cox Plate, while strict social restrictions remain in place for Victorians celebrating the AFL grand final from home.
South Australia has formally joined the trans-Tasman travel bubble after it became the fourth state to unexpectedly welcome Kiwis on flights.
NSW has recorded two new locally acquired COVID-19 cases and three cases in hotel quarantine, as the state government flags relaxing rules for places of worship. The two local cases are linked to known cases or clusters.
Queensland recorded another day with zero cases. Two people are in hotel quarantine after arriving in the state under the federal government's travel arrangement with New Zealand.
US President Donald Trump blasted coronavirus expert Anthony Fauci as a "disaster" in a conference call with campaign workers and sought to reassure them he still had a pathway to win on election day despite slipping poll numbers.
Britain said on Tuesday it would back "human challenge" trials, where young and healthy volunteers were deliberately infected with COVID-19, to accelerate the development of vaccines for the disease.
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This is Rachael Dexter signing off. Take care of yourselves and goodnight.
Exclusive: Victoria 'at risk of repeating fatal hotel quarantine mistakes', as row breaks among departments
By Sumeyya Ilanbey
An interdepartmental row has broken out between Victoria's health and justice departments over how a revamped hotel quarantine scheme should work when international flights to the state resume.
A senior Department of Health and Human Services source has warned that Victoria risks repeating the bureaucratic failings that led to the bungling of the hotel quarantine system, which seeded the state's devastating second wave of coronavirus, infecting almost 20,000 people and killing more than 800.
The Department of Justice - an "unhappy and reluctant participant" in the scheme - has been attempting to shift greater responsibility to DHHS and Alfred Health ahead of the resumption of the program, according to the DHHS source, who has been intimately involved in hotel quarantine but spoke to The Age on the condition of anonymity because they weren't authorised to speak to media.
Both DHHS and Alfred Health have refused to accept a greater role in the program.
UK backs COVID-19 vaccine trials that infect volunteers
Britain said on Tuesday it would back "human challenge" trials, where young and healthy volunteers are deliberately infected with COVID-19, to accelerate the development of vaccines for the disease.
The government said it would invest 33.6 million pounds ($43.5 million) in the studies in partnership with Imperial College London, laboratory and trial services company hVIVO and the Royal Free London NHS Foundation Trust.
The UK government has financially backed COVID-19 vaccine trials that infect volunteers. Credit:Stock
If approved by regulators and an ethics committee, the studies would start in January with results expected by May 2021, the government said.
Britain's hVIVO, a unit of pharmaceutical services company Open Orphan, said last Friday it was carrying out preliminary work for the trials.
Using controlled doses of virus, the aim of the research team  will initially be to discover the smallest amount of virus it takes to cause COVID-19 infection in small groups of healthy young people, aged between 18 and 30, who are  at the lowest risk of harm, the government said.
Up to 90 volunteers could be involved at the early stage, it said.
Imperial College's Chris Chiu, lead researcher on the human challenge study, said the trials could increase understanding of COVID-19 in unique ways and accelerate development of the many potential new treatments and vaccines.
"Our number one priority is the safety of the volunteers," he said. "My team has been safely running human challenge studies with other respiratory viruses for over 10 years. No study is completely risk free, but the Human Challenge Programme partners will be working hard to ensure we make the risks as low as we possibly can."
Melbourne: Golf resumes at Northcote course as local debate tees off
By Rachel Eddie
The return of golf on Wednesday will tee off a larger debate in Northcote, where locals have been using their course as a picnic ground during lockdown.
Residents had cut the wire fence to access the rolling green space when stage four lockdown rules began in August, prompting the City of Darebin to unlock the public course while golf was banned.
People out and about enjoying the Northcote Golf Course earlier this month. Credit:Wayne Taylor
Now that the sport has been allowed to resume, some are reluctant to let go of their newly acquired green space.
Local golfers have splintered into two groups in response: those who believe the 24 hectares can be shared and those who think any change will undermine the nine-hole course.
Bill Jennings, who launched the We Play Golf at Northcote website, believes sharing the course is a slippery slope towards closing it to golfers.
Bill Jennings wants Northcote Golf Course to stay with golfers. Credit:Jason South
He said the public course was one of the few affordable ways for new and diverse players to discover golf.
"I think that golf's not a very offensive sport when you're talking about a public golf course. I understand the stereotypes about elite, entitled privileged white people characterised by people like Donald Trump and Sam Newman. That is not us. You know, people who play down there are not those people."
Mr Jennings wants to pause the debate to see how public space is used once hospitality reopens after the COVID-19 lockdown.
Melbourne residents are still barred from congregating in homes or hospitality venues until at least November 2.
Ruth Liston, from Northcote, has been using the park about three times a week during lockdown and was gutted that golf was resuming.
"It's been an absolute lifesaver for us during lockdown for walks, for picnics for socially distancing with friends, for seeing people and feeling like part of a community, for connecting with nature," Ms Liston said.
"Losing that on Wednesday is devastating. Because even though some of the restrictions have lifted ... life's not going to be normal for a long time."
'I'll stay right where I am': more responses to our Vic-NSW border question
We're reaching the tail end of the blog tonight, and I wanted to thank the many dozens of you who continue to write into us about your plans for when the border between Victoria and NSW opens up again.
We can't publish all of them unfortunately due to the volume of responses, but all of your responses are read though.
The NSW-Victoria border could be opened over the next month, the NSW Premier has flagged. Credit:Justin McManus
I'll stay right where I am... tight border restrictions are one of the best things Australia has in its favour in this crisis. John
Once that border opens, I will go to the middle of NSW to reunite a friend with many boxes of precious books she has stored at my house in Melbourne, then to Sydney for the hell of it, and will return via the South coast to visit another friend, detour to Canberra for galleries and then wind my way back to Melbourne via Gippsland. But if SA opens first I will go there, as I have an expensive travel voucher to use over there and only 'til February to use it. And for those three states / territories, I will take an empty esky. HVM
Job market in Victoria has deteriorated by a huge amount over past 6 months. Will move to Sydney for some opportunity till the situation stabilises. Rahuk
My Dad has final stage lung disease, but not yet in palliative care, so I don't qualify for a border permit. If if I did, it would mean two weeks in quarantine there, and two weeks coming back, so effectively around six weeks away from my husband and kids. FaceTime doesn't cut it anymore for us and all other families - I hope the Premiers in both states realise that. There needs to be a balance found between mitigating this virus and letting people connect and live their lives; extremes don't work. Alison
My immediate family are located in NSW; my extended family are in SA. I became a mum for the first time during the first lockdown in April. At the time, I was devastated that my immediate family could not be there for the birth but luckily they were able to meet my daughter a few weeks later in the intervening period between lockdowns. The physical closure of both the NSW and SA borders has been incredibly tough on my mental health. I cried (not for the first time, mind you) when the photos and stories were published of families reuniting from New Zealand. The fact that I can't see my family (even with the option of quarantining, if I could afford it) in either NSW or SA is devastating. The uncertainty regarding opening only makes it worse - at least QLD has a clear policy on what is required to be achieved in order to open (however achievable), we have no such clarity with NSW or SA. I'm just praying the border opens before Christmas, I'll be an absolute wreck if it doesn't. Lucy
I haven't seen my parents in months. Our three year old asks about his Nanna and Poppy constantly and says he can't wait for the silly germ to go. He's done so much growing up over the last six months, I can't wait for my parents to see him and hug him again. We're originally from Sydney so our closest support networks are up there. We normally make about 8 trips to Sydney every year! My son misses his Nanna and Poppy terribly. He's started chatting up any person over the age of about fifty he meets on the street! Breakfast zoom dates and video call duplo sessions aren't cutting it anymore! We need cuddles! Fingers crossed everyone keeps doing their bit and we can get there soon! Nicole
I am an amputee and have had major reconstruction surgery to my other leg, and all the trauma associated with such decisions, without the support of my family. The thought of seeing my Mum in Sydney again keeps me going, but feels unattainable. Anon
Leave Victoria. This is not the Victoria I grew up with and loved, and it will never be the same due to this insane lockdown. The fact that we're grilled for breathing fresh air, I'm sorry but I can't stay in a place like that for one more minute than I have to. Nathan
I work in the aviation industry and getting any border open is a step forward towards recovery. Aviation is in my blood and it saddens me to see what's happening to our industry. But we are only one part of the the pie, there are millions more who will see benefits to the borders opening up. Anon
Analysis: Trump's feud with Fauci exactly what Republicans want to avoid
By Matthew Knott
Washington: With just two weeks remaining until election day, you might expect US President Donald Trump to be resolutely focused on hammering Democratic rival Joe Biden's weaknesses and outlining his case for a second term.
Instead, Trump spent a good chunk of Tuesday (AEDT) on his feud with Anthony Fauci, the nation's top infectious disease expert. On a conference call, Trump labelled Fauci a "disaster", saying: "People are tired of hearing Fauci and all these idiots, these people, these people that have gotten it wrong."
The US President has taken on a foe who is popular – and trusted – across America. Credit:The Age
On Twitter, Trump hit out at Fauci, saying he had received "more air time than anybody since the late, great, Bob Hope" and making fun of him for his wayward pitch at the opening game of the 2020 baseball season.
At an afternoon rally in Arizona, Trump attacked Biden's coronavirus policies, saying: "He wants to listen to Dr Fauci."
Biden responded on Twitter by simply saying: " ... yes".
This has followed a string of attacks on Fauci over recent days, including Trump labelling him a Democrat and a friend of New York Governor Andrew Cuomo. Fauci has served under Republican and Democratic presidents since the Reagan era and has never been associated with either party.
Taking pot-shots at Fauci is exactly the type of undisciplined behaviour Republican strategists want Trump to avoid at this stage of the campaign. There's no political benefit to be gained from attacking a highly respected and popular national figure.
A September poll by the Kaiser Family Foundation showed that 68 per cent of Americans have a great deal or a fair amount of trust in Fauci to provide reliable information on the coronavirus. That compared with 52 per cent for Biden and just under 40 per cent for Trump.
It's why veteran Republican senators advised Trump to stick closely to Fauci in the early days of the pandemic; they hoped some of his scientific credibility might rub off on Trump with independent voters. But that was the road not taken.
Read the full analysis piece here.
'Open up workplaces': Big businesses ask Victoria to move faster
By David Crowe
Seven of Australia's top chief executives are urging Victorian Premier Daniel Andrews to move more quickly to open the state economy in an extraordinary warning about the damage to jobs and the community from prolonged restrictions.
In a joint letter from big employers such as BHP, the Commonwealth Bank and Wesfarmers, the chief executives warn the current restrictions are unsustainable and must be scaled back so workers can return to their jobs.
Wesfarmers CEO Rob Scott is one of seven big business leaders who have written to Victoria Premier Daniel Andrews asking him to lift restrictions. Credit:Philip Gostelow
"We urge you now, in light of the excellent recent progress, to permit the careful and staged return to the workplace of office workers and the small businesses that provide services to them," they write.
"Safely opening up more Victorian workplaces, based on medical advice and guidance, and enabling the collaboration and creativity that will result, is critical to our state's economic future."
The letter is signed by BHP Billiton chief Mike Henry, Commonwealth Bank chief Matt Comyn, Coca Cola Amatil chief Alison Watkins, Incitec Pivot chief Jeanne Johns, Newcrest chief Sandeep Biswas, Orica chief Alberto Calderon and Wesfarmers chief Rob Scott.
The intervention comes as Mr Andrews hits back at federal government accusations that he is moving too slowly to relax restrictions on the timetable he outlined last Sunday. Retail in Victoria is expected to be open from November 1, or earlier depending on case numbers, with Mr Andrews saying the virus must be dealt with before the economy can recover.
After days of criticism from peak business groups, the new letter marks a significant escalation in the demands from big employers to allow them to reopen offices and stores and redeploy their staff.
The seven executives acknowledge the need for caution and do not demand an instant removal of restrictions or an immediate move to match the rules in place in NSW, which has fewer active coronavirus cases than Victoria.
'Complex equation': Christmas wish may not be granted for stranded Aussies
By Katina Curtis
The federal government insists it is exhausting every avenue to get more than 32,300 Australians stranded overseas home but can't say how many will be back by Christmas.
At the moment, 5575 international arrivals are allowed each week into Sydney, Perth, Brisbane and Adelaide, with the state governments saying that is the upper limit of what their hotel quarantine systems can take.
The first Australians on new repatriation flights will arrive at the Howard Springs quarantine facility on Friday. Credit:Ben Sale
A deal with the Northern Territory to accommodate 500 people a fortnight at the Howard Springs mining camp near Darwin is about to start, with the first government-arranged Qantas flight due to arrive from London on Friday.
Officials from the Prime Minister's department said on Tuesday the Commonwealth was in negotiations with the Victorian government to resume international flights into Melbourne, which they described as a "game-changer". Before its second wave of coronavirus and the cancellation of international flights, the city was taking more than a quarter of the nation's international arrivals.
As well, opening up a travel bubble with New Zealand had freed up about 15 per cent of the hotel quarantine capacity in Sydney.
But department officials could not answer repeated questions from Labor Senate leader Penny Wong about how many Australians would have to return each week to get everyone home by Christmas. Nor could they say when they expected everyone to be able to return.
Breaking: 500 race horse owners allowed to attend Melbourne racetrack this weekend
The Victorian government has just announced that race horse owners will be allowed to attend Moonee Valley racecourse in Melbourne on Friday and Saturday, on top of the already allowed jockeys, club operations staff, security, COVIDSafe marshals and media.
In short, it means up to 1250 people can attend the racecourse for the Manikatos Stakes on Friday and the Cox Plate on Saturday across the whole of the day, with only 1000 allowed on site at anyone time. The venue can host 38,000 people in normal times.
The connections of horses running in the Cox Plate carnival will be allowed on course this weekend. Credit:Getty
The plan for the race meets, which are occurring on the same weekend as the AFL Grand Final, include take-away food and beverage and time limits on how long owners and connections can watch the races.
Minister for Racing Martin Pakula said the allowance, done under the advice of the Chief Health Officer, would allow owners the change to see their horses compete under strict health protocols.
"The change has been closely considered by health officials, who will monitor the implementation of the plan to ensure the health and wellbeing of everyone involved," he said.
The announcement comes as Premier Daniel Andrews this morning urged Melburnians to not break coronavirus restrictions by meeting up with friends and family indoors for the AFL Grand Final on Saturday - the same day as the Cox Plate.
Quarantine a vexed issue for the Australian Open
By Scott Spits
Tennis Australia and government authorities are continuing to thrash out details about the composition of the summer calendar Down Under as Victoria, the home of the Australian Open, slowly creeps out of COVID-19 restrictions.
Victoria's Sport, Tourism and Major Events minister Martin Pakula says "there's a whole lot of work to do" but he remains "extremely confident" the Open will go ahead in Melbourne.
Sofia Kenin claims the 2020 Australian Open. Credit:AP
Quarantine rules in different states for tennis stars arriving from overseas are among some of the sticking points, as well as the amount of spectators allowed on site at Melbourne Park for the grand slam event.
Tennis officials are pushing for quarantine provisions in Melbourne that still allow the world's leading players to take to the practice court, or even play in an event.
"It's really about how the players are allowed to train and practice when they land because they don't want to obviously sit in the hotel room for 14 days without being able to move and do any exercise and practice," Pakula told the Break Point podcast.
"How we get them in and out of Melbourne Park safely, how we keep them and spectators away from one another, how we keep spectators away from each other."
The tennis calendar has taken on a sharply different look in 2020 due to the worldwide impact of coronavirus. Wimbledon was cancelled for the first time since 1945 while the US Open went ahead without fans and the rescheduled French Open unfolded with limited spectators.
In an ordinary year, there would be a number of lead-in tournaments across Australian cities before the global tennis contingent converged on Melbourne Park.
Last year the new ATP Cup men's teams tournament was held for the first time in three cities – Perth, Brisbane and Sydney.


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Q: Command line reverb parameters for FluidSynth The command below renders an audio file using FluidSynth:
fluidsynth -a jack  -o synth.gain=.8  \
   -C0 -R1 -T wav  -F test.wav mypiano.sf2 test.midi

The -R1 parameter activates the reverb. So far so good.
I wonder how I can set the reverb level, reverb width, roomsize and damping.
I tried adding parameters which I respectively found at  http://www.fluidsynth.org/api/fluidsettings.xml and https://forums.scummvm.org/viewtopic.php?t=14379
-o fluid.reverb.level=.3
-o synth.reverb.level=.3
Both resulted in errors (fluid.reverb.level and synth.reverb.level are valid paramaters.
How can I set the FluidSynth reverb parameters using the command line?
I am running on Debian (FluidSynth version 1.1.6)

redpajama_set_name: RedPajamaStackExchange


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OSes
Red Hat eye from the Ubuntu guy: Fedora – how you doin'?
More than a mere RHEL release testbed
Liam Proven in Prague Wed 19 Oct 2016 // 09:09 UTC
Comment Red Hat is the biggest – and one of the oldest – companies in the Linux world, but despite the difficulty of accurately measuring Linux usage figures, Ubuntu and its relatives seem to be the most popular Linux distributions. Red Hat isn't sitting idle, though. Despite its focus on enterprise software, including virtualisation, storage and Java tools, it's still aggressively developing its family of distros: RHEL, CentOS and Fedora.
Fedora is the freebie community-supported version, with a short six-month release cycle, but it's still important. Although RHEL is the flagship, it's built from components developed and tested in Fedora. According to Fedora Project Lead Matthew Miller told this year's Flock to Fedora conference this summer its future looks bright.
After the major "Fedora.next" re-focus in early 2014, Fedora's numbers are up. Both new downloads and updates to installed systems are rising. External involvement – that is, from non-Red Hat staffers – is sharply up: two-thirds of Fedora's contributors are from outside the company these days. And yes, that's counting 'Hatters using non-company email addresses.
It's getting better as a distro, too, benefitting from the improving fit-and-finish of Linux and its manifold supporting components: desktops, applications and their less-obvious underpinnings. Fedora 24 is significantly more usable than it was five or six releases ago. Rather than just being the testbed for future RHEL releases, the project now has wider aspirations – Miller identified the project's primary target as developers.
I must confess, I lean more towards Ubuntu, only periodically dipping a toe into the waters of the RPM world. So when looking at Fedora, it's sometimes irresistible to draw comparisons with the more orangey-purple side of the fence.
And these days it's a family rather than a single distro. The old structure of Fedora Core plus additional rings of functionality has been discarded in favour of multiple "flavours", "spins" and "labs".
"Flavours" are akin to Ubuntu's editions: as well as the standard GNOME 3 desktop, there's Fedora Server plus the ultra-minimal Fedora Cloud. Fedora's "spins" resemble Ubuntu's remixes, offering KDE, Xfce, LXDE, Maté-Compiz and Cinnamon. An interesting addition is SOAS, a live USB drive with the One Laptop Per Child's Sugar environment.
Fedora's Labs are a more versatile equivalent to Ubuntu's handful of special-purpose editions. Labs are pre-assembled bundles of functionally related software, which can be installed as standalone distros or added into existing installations. Finally, COPRs are directly analogous to Ubuntu's PPAs: ad-hoc supplementary repositories to facilitate adding new software that isn't part of the main distro.
The overall structure of the software is changing, too. Platform Architect Langdon White's talk at the conference introduced the Modularity initiative, an attempt to restructure the entire project down into functional modules which can be installed and updated independently, in different ways – for instance as classic RPM packages or container images.
Atomic Workstation represents another possible future direction – a smartphone-like OS, with a read-only root partition, installed and updated via OSTree, with all applications in Docker containers.
As of the version 25, standard Fedora will support the Raspberry Pi 2 and 3. Fedora is an all-FOSS distro, with no proprietary drivers, firmware or plugins, so it doesn't support the Pi 3's Wi-Fi and Bluetooth, as these require binary blobs. (We're told there are efforts underway to help people install closed-source components, such as Chrome, by the way.)
There are still downsides to Fedora relative to Ubuntu. There are no long-term support releases, as that's the role of the technologically much more conservative CentOS. Ubuntu's more pragmatic attitude to including proprietary binaries means more hardware works out of the box, and installing the "restricted extras" package enables Flash, MP3 and so on in one easy operation. But the Red Hat family has come a long way. ®

redpajama_set_name: RedPajamaCommonCrawl


Olivia is an Iyengar yoga teacher based in Muswell Hill, North London. She is a dedicated yoga practitioner having maintained a daily practice for over ten years and being practicing Iyengar for 20. Olivia's teaching is full of energy and insight and encourages a balance between effort and relaxation, adapting yoga postures to suit individual needs.
Olivia is a junior intermediate level 3 teacher in early 2017 and is off to Pune in January.
Olivia has a keen interest in yoga therapy and and for a few years has volunteered at a local iyengar yoga therapy class as an assistant.


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Water-Based, Biocompatible 2D Inks for Printed Electronics
January 31, 2017 By University of Manchester
(Credit: University of Manchester)
Researchers at The University of Manchester have developed a method of producing water-based and inkjet printable 2D material inks, which could bring 2D crystal heterostructures from the lab into real-world products.
Examples include efficient light detectors, and devices that are able to store information encoded in binary form which have been demonstrated, in collaboration with the University of Pisa.
Graphene is the world's first 2D material: 200 times stronger than steel, lightweight, flexible and more conductive of copper. Since graphene's isolation in 2004 the family of 2D materials has expanded.
Using graphene and other 2D materials, scientists can layer these materials, similar to stacking bricks of Lego in a precisely chosen sequence, known as "heterostructure", to create devices tailored to a specific purpose.
As reported in Nature Nanotechnology a team led by Professor Cinzia Casiraghi have developed a method of producing water-based and inkjet printable 2D material inks, which can be used for the fabrication of a wide range of heterostructures by fully exploiting the design flexibility offered by a simple technique such as inkjet printing.
Current ink formulations, which would allow heterostructures to be made by simple and low-cost methods, are far from ideal- either containing toxic solvents or requiring time-consuming and expensive processes. In addition, none of these is optimised for heterostructure fabrication.
Prof. Cinzia Casiraghi says: "Due to the simplicity, flexibility and low cost of device fabrication, we envisage this technology to find potential in smart packaging applications, for example for pharmaceuticals and consumer goods. We are also very excited about the possibility of implementing logic circuits made of 2D materials – indeed, we are further developing these type of devices with our colleagues in Pisa".
Daryl McManus, PhD. student says: "These inks provide a perfect platform to fully exploit the range of properties of 2D materials by allowing for the first time a precise and scalable method for fabrication of devices of arbitrary complexity utilising 2D materials".
Most notably these inks are also biocompatible, which extends their possible use to biomedical applications.
Prof. Kostas Kostarelos, Professor of Nanomedicine says: "The engineering of water-soluble 2D inks that are compatible with the biological milieu and interact with organisms without harm can provide a platform of huge potential for a wide range of applications. We are certainly looking at this as the beginning for such inks in the biomedical arena."
iRhythm CEO considers costs on the path to profitability
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© Artist
KOVIC
KOVIC's debut album "Running Underwater" (24.08.2018) has turned the London music industry upside down. When the record broke the 6 million mark at Spotify alone, the first major labels didn't take long to wait and knocked on the door of the half-English, half-Serbian musician Mark Kovic - just to get a "no".
"I have a strong feeling we're heading into the golden age of music, where opportunities for independent artists have never been better. I get an indescribable buzz with every win our team makes, knowing we have full control of our destiny"
The album was largely written and produced by Jonny Coffer (Beyoncé, Emile Sandé) together with one of Britain's most successful songwriters - Jamie Scott (Justin Bieber, Ed Sheeran) - as well as the first single "Drown", which made it onto the FIFA18soundtrack and various Top50 viral playlists on Spotify. With the following singles, KOVIC was not only placed in various European New Music Friday playlists, but also got great support from the biggest British radio station BBC, who invited him to the Royal Albert Hall for a show at BBC Introducing.
An event of ConcertteamNRW.
16 € Presale Please note: vendors of presale-tickets may charge additional fees.
Stadtgarten-Cards are NOT valid for this event
Order Tickets Tickets also available here


Building off of last weeks heavy single, warm up to the percentage above and hit 6 sets of 3. Remember what we worked on when we were building in our last session.
2. Get under the bar. Don't even think about moving your feet. Start a little wider in your stance and just unlock the knees to catch the bar in a quarter squat. The deeper you can catch the bar, the less you have to move it to begin with. This will play a much more important role this week because our sets are going from heavy singles to triples. Be consistent!
High skill gymnastics movement for the week. Can we take the active shoulders from the strength and apply it to the HS walks? One of the things I try to remember while walking on my hands is that staying as tall and as active as possible through the shoulder allows me to fight fatigue. The more I let the shoulder loosen up and hinge, the more my little stability muscles are required to do and the quicker they fry out. Especially in a WOD like this one designed to put an emphasis on shoulder stamina. Cough, DU's….


text:
package com.lightcrafts.media.jai.opimage;
import com.lightcrafts.media.jai.util.PropertyUtil;

class JaiI18N {
    static String packageName = "com.lightcrafts.media.jai.opimage";

    public static String getString(String key) {
        return PropertyUtil.getString(packageName, key);
    }
}

redpajama_set_name: RedPajamaGithub


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A word with Stuart Wason, Chair of the Insurance Regulation Committee
Stuart Wason is a semi-retired FCIA who is nearing the end of his term as Chair of the International Actuarial Association's (IAA) Insurance Regulation Committee (IRC). We sat down to discuss the importance of his role, the IRC's top contributions and challenges, and implications for Canadian actuaries.
How did you become involved with the IAA and the IRC in particular?
My involvement with the IAA began in 1999 when I was President-Elect of the CIA. In 2004 I helped lead an IAA team that developed a publication for the International Association of Insurance Supervisors (IAIS) entitled "A Global Framework for Insurer Solvency Assessment."
The report explored the elements needed for an international capital standard for insurers and provided a "best practices" approach for supervisors. My career took me away from the IAA for several years after assuming a senior role with the Office of the Superintendent of Financial Institutions (OSFI) in 2007 – a position that allowed me to become more heavily involved in various IAIS committees.
Following my retirement from OSFI in 2016, I was invited to rejoin the IAA and the IRC as part of a team of CIA members guiding the international actuarial profession's response to regulatory issues. The world of insurance financial reporting has become more internationally integrated, and my role has been to help guide and develop the relationship between the profession and regulators at the global level in a rapidly changing environment.
I have always enjoyed meeting actuaries from around the globe and learning from their actuarial and regulatory perspectives. I have often felt that should I need assistance in a foreign jurisdiction, there would always be an actuary there with whom I could connect.
For our readers who may not be familiar with the work of the IAA or your committee, can you explain its role and importance?
While the CIA is the professional association of Canadian actuaries, the IAA is the global association of actuarial associations, including the CIA.
One of the very active IAA committees is its Insurance Regulation Committee (IRC), comprised of actuarial members from across the globe. The purpose of the IRC is to promote the role of actuaries with respect to regulation and supervision, to support the development of international actuarial principles and frameworks for regulation and supervision of insurers, and to provide a forum for discussion of supervision/regulation issues and approaches.
The IRC has the lead role in connecting and building closer IAA ties with the International Association of Insurance Supervisors – of which OSFI (Canada's own supervisor of federally regulated banks, insurers, and pension plans) and the Autorité des marchés financiers (AMF) are members.
It has become increasingly crucial for the actuarial profession to have a global voice, especially when contributing actuarial perspectives on a variety of issues, such as insurer capital standards, risk management, climate-related risks, and pandemic-related risks – to name just a few.
What are some of the greatest accomplishments achieved by the IRC?
A key achievement made by the IRC in recent years has been the strengthening of ties between the IAA and the IAIS – one of the IAA's most important supranational relationships. A few examples of the progress made include:
The IAA participates regularly at various IAIS public forums. IAA and IAIS leadership meet routinely several times a year, resulting in greater co-operation on key work projects such as insurance capital standards, climate risk, ORSA, and the pandemic.
Collaboration has resulted in the signing of a partnership agreement between the Sustainable Insurance Forum (SIF), a group of insurance supervisors focused on climate-related risks, and the IAA. The CIA's own, Micheline Dionne, FCIA, has assumed the relationship manager role for SIF.
Supervisory capacity building organized with the support of the IAIS and under the direction of the Access to Insurance Initiative (A2ii) now includes actuarial trainers from the IAA on a regular basis.
Building an online library of IAA publications showcasing the work of actuaries on a variety of risk-related topics. This risk book library, accessed by both actuaries and insurance supervisors, includes more than 20 topics written by actuarial experts from around the globe.
The IRC meetings allow IAA member associations an opportunity to share news of supervisory developments in their jurisdictions and to support the development of international actuarial principles and frameworks for the regulation and supervision of insurers.
What should Canadian actuaries know about the work of the IRC?
First and foremost, as the work of the IRC involves insurance supervision and regulation, Canadian actuaries can be proud of their insurance supervisory framework (e.g., as established by OSFI and AMF for example) and the progressive nature of the relationship in Canada between supervisors, industry, and the actuarial profession.
Our collective achievements over many years in developing financial condition testing (e.g., DCAT), financial reporting (e.g., CGAAP), modern capital standards (e.g., LICAT and MCAT), and effective risk-based supervision are well recognized. However, many challenges lie ahead, and Canadian actuaries need to be active participants and leaders of the work and the opportunities before them.
A current challenge for Canadian insurance actuaries is preparing for IFRS 17 while for larger insurers, it is the introduction of the IAIS' new global capital standards. Beyond these topics is a relative tsunami of effects due to the pandemic and climate-related risks. Within each of these topics lies a wealth of opportunity for the actuarial profession to add value to society in managing these risks.
Undoubtedly, the Institute and its actuaries will play key roles, but as these risks are global in nature, so too will the IAA have a vital role in supporting its member associations and being the global voice of the actuarial profession.
Any last words for our readers?
I would encourage your readers to consider volunteering in any of the various CIA or IAA committees that are focused on today's key issues (e.g., climate-related risks, sustainability, cybercrime). Increasingly it appears that a co-ordinated international response is needed. There is an urgent need for the actuarial profession (both locally and internationally) to build on its core strengths and play key roles in helping to tackle these problems.
Committee FCIA IAA Interviews Volunteers
Examining the considerations of going concern discount rates for pension plans


Adulteration is tantamount to slow poisoning of consumers and is indulged in by dishonest traders only to make quick bucks .It is a crime against humanity. Still worse crime is the patronage given by those who are paid by the state to stop it. The malady is wide spread, organised with deep rooted nexus. A case here and an instance there coming to limelight are just tips of iceberg. Adulteration is so rampant and so deep rooted that nothing short of more deterrent legislation and high degree public awareness would make some impact on it.
What is State Food Safety Department doing? How many cases of adulteration on monthly basis does it handle and taking them to the logical ends? Are persons of proven impeccable integrity and honesty posted in this department? The fact of the matter is that the rut is phenomenal. However; Government recently attached two officers of the Food Safety Department and purged them of their "powers" over allowing supply of sub-standard edible oil in Anantnag district of South Kashmir. They are Assistant Commissioner, Food Safety and Food Safety Officer Anantnag. Both of them have been kept attached with the office of Deputy Commissioner, Food Safety Kashmir. We feel this "punishment" is not enough.
Our readers may recollect, had reported very recently that various companies were allegedly supplying sub-standard edible oil in Anantnag district and other parts of the valley under the long but stuffed nose of Food Safety Department . No samples of oil were taken for testing and verifying their authenticity. Loose edible oil is being brought from outside in tankers and then packed in Anantnag town for the last several years and "Hafta" regularly paid by the unscrupulous traders. It is shocking when the reporter of Excelsior contacted Food Safety Department; he was offered a bribe of Rs.50000 for not publishing the fact of adulteration on this massive scale. It is left to no imagination as to the extent of deep rooted nexus of traders- Food Safety officials- Police and others operating in Jammu and Kashmir state.


I was so excited when I received this book.
fun it's going to be!
as it's soft, warm & easy to wash.
the thickness of the fabric so is very forgiving.
Now I will always prefer crocheted hats.
That has something to do with the fact that I am a crocheter.
However I will be making Little Red at least one of these.
They are so bright and fun!
are good enough that you would be able to design your own as well.
You could also amend the hats to give them your own personality.
You get templates for hats in sizes extra small, small, medium & large.
At the start of the book you get all the basic templates.
These templates are everything from the hat itself to the earflaps.
get the templates specific to that pattern.
You also get all the tools and materials you will need.
Easy to follow step by step instructions are also given.
I found them really easy to understand.
Some parts of the project are handsewn & some are machine sewn.
giraffe scarf & monkey applique.
Some of the templates also need increasing in size.
So you'll need to be able to copy and resize.
so you'll have lots you want to make.
There is sure to be something to make you smile.
These would make fantastic gifts for family and friends.
However all opinions expressed were my own.


text:
At least two explosions, one particularly powerful, have been reported in the Afghan capital Kabul near a military hospital in the center of the city. Witnesses claim the explosions were followed by bursts of gunfire.
On Tuesday, multiple blasts were heard across Kabul from the Wazir Akbar Khan area of the city, near the Sardar Mohammad Daud Khan military hospital. Photos shared online appear to show dense smoke rising above the city.
Thick smoke cloud coming out from Sardar Dawood Khan hospital following the second loud explosion. #Kabul pic.twitter.com/WsU2gJNHDn
— Anas Mallick (@AnasMallick) November 2, 2021
According to Afghanistan's TOLOnews, Bilal Karimi, the deputy spokesperson of the Islamic Emirate, confirmed that two explosions occurred in Kabul city's district 10. Karimi added that both blasts had occurred near the hospital.
Interior Ministry spokesman Qari Saeed Khosty tweeted that there had been explosions at the hospital entrance, and that "special forces of the Islamic Emirate have been deployed to the area." He added that information concerning casualties would be shared later.
Footage shared online by correspondent Soraya Lennie appears to show black smoke emanating from the far side of the city. She claimed that the second explosion was much bigger than the first.
About 12.45 local time. Heavy (sporadic) gunfire for about 10 minutes after. Reports of suicide bomber as yet unconfirmed. The facility is the largest military hospital in the country, with 400 beds. https://t.co/EpftZZo915
— Soraya Lennie ثریا لنی (@soraya_lennie) November 2, 2021
Lennie said that "heavy" and "sporadic" gunfire had broken out about for around 10 minutes following the first explosion at around 12.45 local time (8:15am GMT). She noted that the blast occurred near the country's largest military hospital, which has some 400 beds.
State media agency Bakhtar News, citing witnesses, said Islamic State fighters had entered the hospital and clashed with security forces.
Also on rt.com
US-trained Afghan soldiers & spies joining ISIS terrorists to 'resist' Taliban – reports
Terrorist groups affiliated with Islamic State have carried out a number of bombings since the Taliban's capture of Kabul in August, often targeting mosques and causing a vast number of casualties. Islamic State attacked the Sardar Mohammad Daud Khan military hospital in 2017, killing more than 30 people.
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Access: from the country hamlets of Ponte Mas (if you come from the road Belluno Agordo) and of Mis (from the road Feltre Belluno and from the provincial road "Pedemontana").
Environmental context - Description of the site: the complex is situated at the entrance of Val Cordevole and dominates the homonymous "masiere" (stony grounds), at an altitude of about 430m, on the slopes of Piz di Vedana dominating the complex. The position, of great landscape interest, meet the needs of isolation required by the Monastic Order. At about 10 km from Belluno, it lies within the administrative borders of the Municipality of Sospirolo and within the perimeter of the Park.
Building period: the works to build the Charterhouse began in 1456; in the years following 1882, the final enlargement and partial reconstruction works were carried out.
Architectural features: monastic complex of the Carthusian Order. The architectural structure reflects the aggregative features and the premises characterizing the Charterhouses, organized according to the severe "Customs" of the Fathers who, despite belonging to a community, live a rigorous isolation. The settlement model of the Charterhouse of Vedana is inspired to the dictates of an ideal plan probably by the Carthusian monk Antonio Arlotti, then adapted to the nature of the place and modified. The structures as we see them today are the fruit of a reconstruction and enlargement measure which took place in the years following 1882, when the complex was purchased by the Prosecutor of the Great Charterhouse of Pavia; the partial project is ascribed to the architect Francois Pichat. Great historical – architectural value.
The monastic system is characterized by a severe and rather simple structure, despite the several 19th century decorations, if we exclude the Church and the outdoor garden and cloister characterized by a more monumental aspect (according to the tradition, Palladio planned the Honor Staircase, made with Trento stone, and the overhanging gallery). The premises following one another and aggregating, adapting themselves to the features of the site, reflect the plan of the Charterhouse, strictly linked to the customs of the monastic life. The complex includes three essential nuclei: the big cloister, where the cells of the monks and of the Prior face, arranged on two floors and each characterized by a letter of the alphabet leading to the sentences taken from the Holy Scriptures reproduced on the respective access doors; this was the burial place of the Carthusian monks; the small cloister, around which the premises of the community life develop, like the monastery Church, the Sacristy, the Choir, the Chapter House, the Refectory, the Library; the so-called "cloister of the lay brothers", where the premises alien to the monastic life used to face. In the middle of the complex, the Church connects the area of the Fathers to the area of the lay brothers. With the 19th century renovation works, also the cemetery chapel "of the Compassion" was annexed to the cemetery, in the northernmost section of the complex, next to the walls.
Charterhouse in 1456. After the suppression of the community in 1768, it was transformed into a farmstead. According to the 1847 Land Register, the estate is still used for agricultural practices and part of the buildings are classified as ruined Monastery; in 1882 the Charterhouse was rebuilt as we see it today, partly recently restored. In 1977 the monks were moved to other localities, and the Charterhouse welcomed a community of cloistered nuns.
The Charterhouse of Vedana is the most important historical-architectural feature of the Park and one of the most important monuments of the whole Province of Belluno. The history of the complex, situated at the entrance of Val Cordevole and dominates the homonymous "masiere" (stony grounds), is strictly linked to the hospitales situated at the edges of the route leading to Agordo. From the beginning, the hospice of S.Marco di Vedana, situated at the current nucleus of S.Gottardo, used to control the hospice of S.Giacomo di Candaten (founded more recently, the first documents date back to 1194-1208) and the hospice of S.Bartolomeo d'Agre. After the building of the Charterhouse, S.Gottardo was reserved to lay brothers devoting themselves to agricultural activities and accommodation.
The thematic itinerary of the Park called The Route of the Hospices has been recently created: it leaves from the Charterhouse and reaches Valle Imperina; this interesting itinerary gives the opportunity to better discover the theme of the ancient accommodation structures for wayfarers existing along the main route of Val Cordevole, one of the most important north-south routes of this section of the Alps. Directions and information panels along the itinerary and at the main "laps".
AA.VV. - La Certosa di Vedana. Storia, cultura e arte in un ambiente delle Prealpi Bellunesi, Leo S. Olschki, Firenze 1998.
Bacchetti F., Selle M. - Certosa di Vedana, Pro Loco "Monti del Sole" - Sospirolo (Bl), Tip. Piave, Belluno 1993.


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Overall, majority of Americans approve of Obama's State of the Union address
Overall, 55% of the 31.3 million people who tuned in to President Obama's final State of the Union address on Tuesday night felt positively about his remarks.
President Barack Obama delivers his State of the Union address to a joint session of Congress on Capitol Hill in Washington, Jan. 12, 2016.
Jan. 15, 2016, 2:03 AM UTC / Updated Jan. 15, 2016, 11:02 AM UTC
By Hannah Hartig and John Lapinski
Overall, 55% of the 31.3 million people who tuned in to President Barack Obama's final State of the Union address on Tuesday night felt positively about his remarks. This majority approval may be artificially high, however, because more Democrats watched or followed the speech than Republicans. These results are according to a NBC News|SurveyMonkey poll conducted online from Jan. 12 to Jan. 14 of 3,782 adults.
Perhaps following the lead of Republican presidential candidate Ted Cruz—who boycotted the speech— only 26% of those who watched the speech live identify as Republican, while 45% identified as Democrat and 28% identified as independent. The president's last State of the Union address brought in far fewer viewers than his first State of the Union, which had 52.4 million viewers, according to Nielsen estimates – a trend that has been experienced by other two-term presidents.
When looking at the ratings by party, 55% of Democrats who watched or followed were enthusiastic, and another 38% were satisfied with Obama's remarks. Just 5% were unsatisfied or angry. In contrast, 84% of Republicans reported being angry or dissatisfied following the speech.
Obama's annual report to the nation was received more positively among younger Americans, who tend to identify as Democrat. Among those 18-24, 73% were enthusiastic or satisfied with his speech, but only 52% of those over the age of 65 felt similarly.
Women were also more likely to express enthusiasm than men—31% to 20%. This is not surprising given there is a gender gap between the parties, with women generally outnumbering men in the Democratic Party.
Generational differences are evident in both parties, but especially among Republicans. Republicans overall were more negative on the president's speech, in which he laid out the case that the country has changed for the better under his tenure and expressed frustration at the growing partisanship in Washington and across the country. But younger Republicans were much less intense in their disapproval than older Republicans. While 43% of Republicans over 65 were angry, only 30% of Republicans under 35 were also angry. Nearly 3 in 10 young Republicans under 35 actually expressed positive reactions to Obama's address.
A majority of Democrats under 35 as well as Democrats over 65 were enthusiastic. Those between 35 and 55 years old were less approving, but still expressed overall satisfaction with the remarks.
Allison Kopicki, Josh Clinton and Sam Petulla contributed to this article.
This NBCNews|SurveyMonkey poll was conducted online from January 12-14, 2016 among a national sample of 3,782 adults aged 18 and over. For full results and methodology, please click here.


text:
Are you an emerging leader looking to grow your network, build your leadership toolkit, and collaborate on solving our region's most pressing civic issues? Then it's time to sign up for CivicAction's Emerging Leaders Network (ELN)!
The ELN connects, develops, and activates rising leaders from across the Greater Toronto and Hamilton Area (GTHA). By filling out this short registration form, you'll be added to our monthly newsletter and will get first access to sign-up for our programming.
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Please select... To grow and diversify my network To develop my leadership skills To gain a deeper understanding of civic issues To gain awareness about community engagement opportunities To engage with CivicAction's network and work To make our region more inclusive and accessible
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New brands positioned as alternative to "major name brands"
The Dixons Group is introducing four 'own brand' labels at Currys and PC World.
The company said the brands would span basic utility products through to high-end technology for the home and that products in the range would be arriving in stores from August, however at least some of the brands have existed for some time already such as Currys Esentials and PC World Essentials.
DSGi said that 'Currys Essentials' is a brand created to offer "straightforward, no-nonsense, functional products at an unbeatable price." The company cited a wide variety of product genres and target consumer from "an office worker in need of a kettle" to "home buyers looking to equip their first kitchen."
'PC World Essentials' will be take aim at IT specific product categories which the company describes as "computing related products and accessories including cables and printing inks, USB sticks, mice and netbooks."
At least some duplication between brands seems likely since Currys Essentials and PC World Essentials have appeared for items such as printer consumables.
The 'Logik' brand will offer small screen televisions, DVDs, kettles, toasters and headphones in a range which DSGi said "has been designed to be used everyday with an emphasis on reliability and efficiency."
'Sandstrom' will cover much the same kinds of products such as blenders, kettles, toasters, microwaves and dishwashers as well as TVs, but the company said this range is "inspired by Scandinavian design and living and includes a wide range of products designed to combine aesthetics with performance."
DSGi emphasises value in both the descriptions of the Logik and Sandstrom ranges compared to "major name brands" and "higher-end consumer technology brands" respectively, pointing to a lower end focus for Logik and a top-shelf status for the Sandsrom range.
Another of the brands, 'Goji', DSGi describes as "a design-led brand offering a range of smart and fashionable bags and storage for electronics on the move." The product category will cover cases and wearable accessories such as computer bags, iPod cases and headphones.
DSGi also drew attention to the existing Advent PC brand, announcing that it it would launch a range of personalised laptop covers. In a move which the company describes as "an industry first", customers will be ale to apply user supplied custom pictures to laptop covers.


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text:
Optimer™ Technology
Applications of Aptamers in Immunohistochemistry (IHC)
Cancer histopathology is currently the preferred method for detecting microscopic anatomical changes in tissue sections, making the discovery of cancer biomarkers critical for early diagnosis and treatment. Antibodies have been used extensively as the molecular probes; however, the production of antibodies requires a series of complicated and time-consuming processes.
There is no question that aptamers can offer benefits over antibodies, as they have been demonstrated as excellent probes for immunostaining of frozen and formalin-fixed and paraffin-embedded (FFPE) tissues. Aptamers have unique properties that make them advantageous in future clinical settings by overcoming the limitations of antibodies. These include:
Isolated in vitro, without the need of animals
Small size which allows increased penetration into cells and tissues
Non-immunogenicity
Significantly lower batch to batch variation
Reduced cost and faster production
Potentially increased stability and convenient storage
Moreover, in direct comparison with antibodies in IHC, aptamer probes provide:
Optimal staining with shorter reaction times
Less restricted antigen retrieval conditions
Reduced time to perform the aptamer histochemistry technique
Lower background staining (negligible non-specific binding)
The flexibility of aptamers means they can be easily conjugated with a wide range of tags for imaging without affecting selectivity or affinity. In this view, the following researchers have reported the use of fluorescent/biotin tagged aptamers in aptahistochemistry for the characterization of the histological structure of cancer tissues.
Selective staining of Lung Adenocarcinoma Tissue
Zamay et al. selected three aptamers LC-17, LC-18 and LC-224 to postoperative lung adenocarcinoma tissue for histochemical analysis of biomarkers, tumour cells, blood vessels and connective tissues. The aptamers showed binding to various tumour specific biomarkers and tumour structures such as elastic fibers, tumour cells, blood vessels, and elastin all of which play important roles in tumour progression. Also, these aptamers did not stain normal lung tissue confirming that they only have an affinity to elastic fibers that have been modified due to a malignant process.
Selective staining of Breast Cancer Tissue
Ahirwar et al. attempted to ascertain the clinical applicability of breast cancer-specific aptamer in evaluating the ERα expression, by selective staining of ERα-positive cells, to assist in breast cancer diagnosis and grading. An aptahistochemistry assay was performed using biotinylated-ERaptD4 on deparaffinized and hydrated tissue sections of breast cancer patients. Aptamer ERaptD4 showed specific staining in the nuclei of ERα positive breast cancer cells where it specifically stained the malignant duct cancer cells without any cross-reactivity to fibroblasts, adipocytes, inflammatory cells or extracellular components.
Selective staining of glioma tissues
Similarly, Aptekar et al. determined the effectiveness of aptamers in recognizing and differentiating between different grades of glioma and non-cancerous brain tissues. Staining of tissue sections was graded using a UK NEQAS scoring system. The aptamer SA43 showed moderate to strong nuclear staining in tumour tissues with an average score ranging from 4–6.6, whereas, in non-cancerous tissues, the average score was only 2.9. The random sequence aptamer showed comparatively negligible binding to the non-cancerous and tumour tissues. Moreover, the aptamer showed selective binding to endothelial cells in tumour tissues.
Overall, these findings have opened the door to aptamer histochemistry applications in both research and clinical settings, including intraoperative diagnostics in which speed and accuracy are paramount.
At Aptamer Group Ltd, we start with the end in mind by designing the aptamers according to the customer-specific requirements, so that they are optimized for end applications. For such IHC applications, we isolate the aptamers directly against the cells/tissues of interest; after they have undergone all the necessary treatments (fixation, embedding, antigen retrieval, etc). Taking this approach means that we isolate the aptamers against the antigen, as it will be presented in the final application. This helps to ensure that the aptamers are fit for purpose faster than traditional technologies. If you want more information on exploring applications of aptamers in IHC, please get in touch.
Ahirwar R, Vellarikkal SK, Sett A, Sivasubbu S, Scaria V, Bora U, et al. (2016) Aptamer-Assisted Detection of the Altered Expression of Estrogen Receptor Alpha in Human Breast Cancer. PLoS ONE 11(4): e0153001. https://doi.org/10.1371/journal.pone.0153001
Aptekar S, Arora M, Lawrence CL, Lea RW, Ashton K, Dawson T, et al. (2015) Selective Targeting to Glioma with Nucleic Acid Aptamers. PLoS ONE 10(8): e0134957. https://doi.org/10.1371/journal.pone.0134957
Zamay GS, Ivanchenko TI, Zamay TN, et al. (2017). DNA Aptamers for the Characterization of Histological Structure of Lung Adenocarcinoma. Mol Ther Nucleic Acids.6:150–162. doi:10.1016/j.omtn.2016.12.004
breast cancercancerdiagnosticgliomahistochemistryIHCimmunohistochemistrylung canceroncology
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By the time you're reading this, Jake and I will just be returning from our spring vacation to Cancun. It's been over a decade since I've been a proper spring break, and as a Minnesotan, it's well deserved. We're not usually the type to travel to an all inclusive or fancy place, so this trip was likely going to be a once-in-a-lifetime trip. So I kind of went all out! So here's my Mexico packing list, including beauty, accessories, and some thrifted outfits from someone who doesn't consume fast fashion.
Last summer, our friends approached us and said they wanted to do a trip together during spring break. I didn't need to hear more. Minnesota's winters are BRUTAL you guys. I don't think I can even explain it. So there was no way I was turning down an all-inclusive resort in March. I'd also never been to Mexico, or any part of Latin America, so it was a way to add another country to my travel list.
For our trip, we decided to check one bag between the two of us. Jake and I lost our luggage during our trip to Iceland a few years ago (we got it back a few days later) so I'm also hesitant to check a bag. But we were going to need more than 3 ounces of sunscreen for Jake and 3 ounces of conditioner for my curly hair. We were also bringing sun hats, which I considered wearing on the plane, but that would be annoying 🙂 so into the luggage it went.
For the majority of my clothes and items, I packed them in a carry on and my backpack as my personal item. Also, packing for Mexico is a little different than other places we've travel too because all the pieces are smaller and lighter. So they roll up very small.
I'm not going to lie, I may have packed a few too many extra outfits. But I needed options.
Bikinis – I brought three suits for five days – I wanted options!
Romper – I brought my romper as a swimsuit cover. Something semi-dressy for grabbing a quick bite at the poolside restaurants.
Sun Hat – I'll admit, I love catching some sun and getting a tan. But I always keep my face out of the sun when I can. A sun hat with a large brim is essential beach side.
Beach Bag – Back in January, I thrifted the cutest, nautical inspired bag for our trip and future trips to the lake. It's the perfect size for sunscreen, some snacks, a towel, and my tablet. I treated the bag with a bit of Scotchgaurd and packed it away.
Sun Dresses – I may have packed a few more than I needed, but one for each day should do.
Sandals and Flip Flops – I brought casual sandals that I could dress up with a cute outfit or walking through the resort. I also thrifted some brand new Champion flip flops a week before our trip that would hold up to the water and sand.
Dress Wear – Some of the restaurants have stricter dress codes, so I was sure to bring a nice dress, comfy heals, and a light cardigan.
Denim Jacket – An essential piece for all travel, in my opinion.
Athletic Wear – When it comes to excursions, I keep is casual and comfy. For the hot weather in Cancun, I packed some light athletics clothes and tennis shoes. Me and girl friend also planned a few days in a fitness class while we were there!
Bralettes – If I'm being honest, I only wear bralettes these days versus the traditional wired bra. They fit my athletic figure comfortably and are easy to hand wash.
SPF & Aloe Vera – Sun burn just ain't cute, so pack some extra sunscreen just in case. I also packed Lily of the Desert Aloe Vera Gelly for the potential skin burns. I was even sure to grab lip balm that includes SPF 30 because burned lips are no fun. Target had this mango Sun Bum lip balm in the travel section and I couldn't say no.
Herbal Essence Hello Hyrdation Conditioner – Since we checked a bag, I brought a full size conditioner to detangle the mane after swimming. This is my go-to travel conditioner because it's affordable, hydrating, detangling and curly girl friendly!
Lorac Unzipped Palette – My favorite summer palette with rose golds and bronze colors, so I knew it would be going with me.
It Cosmetics Your Skin But Better CC+ Cream – I originally received this as a sample a few months ago, and immediately knew I wanted it for our trip. The base product has SPF 50, good coverage, and is very comfortable to wear. It doesn't keep me fully matte, so I brought a mattifying primer and good powder for blotting.
Flower Beauty Blush Bomb Color Drops in Nectar – This was a new product to me, and it turned out to be a perfect coral that pops on my tan skin.
Maybelline Color Tattoo Bad to the Bronze – Perfect for quick and easy eye looks!
Waterproof Mascara – Between the humidity and water activities, I wanted a waterproof mascara. My favorite mascara at the moment is the L'Oreal Lash Paradise – I brought a regular and waterproof. Don't forget makeup remover!
First Aid Supplies & OTC Medicines – You never know what could happen when you're traveling. Be prepared! So I packed up your basics – bandages, antiseptic and antibacterial cream, antacids, ibuprofen, antihistamines, etc. I also packed some PeptoBismol and other stomach-friendly medicines, just in case we consumed a bit of the local water.
Even though we were traveling to an all-inclusive, I still like to travel with a few snacks for the airport or during excursions.
Quest Protein Bars – My favorite for traveling! I've shared my favorite travel snacks before, and these are always included.
Trail Mix – Something for quick snacking!
Backpack – The ultimate bag! I love traveling with my Eddie Bauer backpack – it's water resistant, holds loads of stuff, and zips/clips closed. I purchased this bag before our Gatlinburg vacation, and use it for traveling, trips to the lake, picnics and more.
Clutch Purse – Something small that will go with all your outfits that you can take to dinner. I have a Fossil side purse I purchased a few birthday's ago, and it's perfect! It small enough to carry, but durable enough to pack full of essentials.
You know, the official stuff and things you can't live without.
Check out more of my travel adventures here and keep up with me on my social media! Post coming soon on everything we did during our trip.


Today is Windermere Real Estate's 26h Annual Community Service Day. Windermere agents will be completing service projects in our neighborhoods across the West. Community Service Day gives us an opportunity to give back to the communities where we live and work.
Every year since 1984, Windermere associates dedicate a day of work to complete neighborhood improvement projects as part of Windermere's Community Service Day. Each Windermere office selects a project that best serves its community needs.
Tweet with us today to support local YMCA programs!
Join us on Twitter as we share local projects as they happen. Tweet with us using the hashtag #wrecsd on June 18, 2010 and the Windermere Foundation will donate $1 per tweet to the Windermere Kids at the Y fund (up to $25,000), supporting 10 local YMCAs.
Coast Harvest Food Bank. Assisting in the sorting, storing and packaging of food.
Childhaven. Landscaping maintenance around the facility.
Little Bit Therapeutic Riding Center. Painting horseshoes and jumping poles, cleaning and general maintenance.
Mamma's Hands. Building vegetable gardens, rebuilding deck areas, landscaping and gardening and general maintenance.
Boys and Girls Club in Blaine. Repaint the interior of the club, yard maintenance, repainting basketball court and resodding field.
Bend Community Center. Landscaping and painting.
Jesse Tree. Assisting an organization that helps homeowners stay in their homes.
Local food bank. Coordinating a community food drive.
Seaside Victory Gardens. Gardens will be used to grow fruit and vegetables for local food banks. The office will be painting the tool shed and working in the garden.
Historic Fox Theatre in Centralia.
Oregon Food Bank. Assisting in the sorting, storing and packaging of food.
Westgate Elementary. Returning for major clean up and landscaping.
Food For Lane County Community Garden.
Bethel School District. School yard work at two locations.
Community Action. Landscaping and general maintenance.
Kaunoa Senior Center. Working on a landscaping project.
Public trail system. Working with other local volunteers.
Habitat for Humanity. Building siding and landscaping.
Medical Teams International. Packaging medical supplies and equipment and preparing them for overseas shipment.
Community Garden for Lynnwood Food Bank. Building planter boxes and signs.
Fred Habenicht Park and Black Diamond Ridge community area working in conjunction King County Parks and Recreation to prepare for summer visitors.
YMCA in Mill Creek. Doing construction projects and hosting a community BBQ.
YMCA. Community swim day with free ice cream and discount admission.
Mukilteo Food Bank. Donating and collecting food at various locations in the community.
Senior housing. Cleaning up and taking care of landscaping for seniors in need.
Ainsworth Elementary School. Sanding, cleaning, painting and organizing around the school.
Friendly House. Sprucing up indoor and outdoor spaces.
Hopewell House Hospice. Planting flowers along walkways to improve views and taking care of general maintenance.
Raab Park. Rehabbing a music stage in the park to hold community concerts and music festivals. Partnered with Home Depot to help with the build and provide supplies.
Pullman Parks and Recreation. Beatification project on South Grand Avenue, Pullman, WA.
Marion-Polk Food Share. Sorting and packaging items for distribution, and tending to the organization's vegetable garden.
Daniel Bagley Elementary. Working on their new "Outdoor Classroom" area assisting with various projects including construction of a shed and benches as well as a work table. If time will get in a little weeding!
Olympic View Elementary School. Planting flower beds.
McClure Middle School & Queen Anne Community Center. Working on a very large landscaping project and some painting.
Theodora. A HUD 202 serving older adults who have an income less that 50% poverty.
The Children's Book Bank. Repairing, sorting and packaging children's books.
Ryther Child Center. Landscaping and gardening the grounds and play areas.
Garden of Hope for Ronald McDonald House. Taking a vacant lot and transforming into a garden.
Columbia Pacific Food Bank. Tending to the community garden.
YMCA. Re-do the landscaping at their soon to be new location with the Tri-Cities - Richland office.
Local Parks Department. Building a bike skills course at rec center they are developing to create a nice fun, safe place for kids on the island.
YWCA Battered Women's Shelter of Yakima. Remodeling a safehouse for Women and children. Rod's House. Collecting basic necessities for a safehouse for homeless.
Let us know in the comments if you see any Windermere volunteers in your neighborhood or send a tweet! Remember each tweet with the hashtag #wrecsd will benefit the Windermere Kids at the Y fund!
This post was written by Katherine Garsi.


Another New York gallery for 2016 ! Here's some pictures from my last trip to the city I love, I dream, I hate.
Yes I know, lots of NYC stuff in this site already but I can't help myself when it comes to the Big Apple. I travelled with friends and among them, Attilio, celebrating his 50 years, that and photography made this trip.
A new calendar with pictures taken during my 2013 and 2014 trips to the Big Apple. 13 Color printed 60x35cm photographs with your chosen year and starting month. If you are interested in buying one drop me a message via the contact page.
Music Credits : Tumbling Tumbleweeds (Sons of the Pioneers), The Sound of da Police (KRS One), Jericho (The Prodigy), Klaus I Love You (M83), Imagine (John Lennon), Billie Jean (Michael Jackson), Mine (George Gershwing).
These two shots taken from the Empire State Building are 31 years apart. The first was taken by my mother during our first US visit with her trusty Canon A1 and I took the second one last April. The old slide was taken in summer whilst the 2013 shot was taken in spring.


Tracing nearly eight decades of flying, the Douglas-Hamilton Ethos and Heritage Room at RAF Benson charts a colourful and varied history from 1939 to the present day.
Volunteer curator Michael Prendergast took Forces Radio BFBS Brize Norton's Jo Thoenes around six galleries dedicated to this story, that include collections from The King's Flight and the former Photographic Reconnaissance Unit, through to the modern face of the station and its place within Joint Helicopter Command.
And there is a personal connection for Michael taking on this project as he previously served at RAF Benson in a number of roles.
"I was actually on the Queen's Flight. You didn't always know what time you finished, but you knew when you went to work you were doing a really good job."
The facility is named after the four Douglas-Hamilton brothers who served within the Royal Air Force; all holding the rank of Squadron Leader or above on the outset of the Second World War.
A plaque dedicated to the youngest brother, Lord David Douglas-Hamilton who served at RAF Benson, tells the story of his flying career, and untimely death after his aircraft crashed on its approach to RAF Benson, following a mission to southern France in 1944.
But some of the exhibits tell stories of more than just the Royal Air Force.
A former station chaplain, Marcus Morris went on to found the classic British comic The Eagle.
Sarah, Duchess of York earned her 'wings' at RAF Benson, and His Royal Highness Prince Charles' flying suit forms a part of the collection too.
"It was quite strange post war, a padre making The Eagle comic, but he made it, he's got Dan Dare... and you look into what he was doing..."
Michael regularly hears from people who have had family serve at RAF Benson, and are looking to complete the stories they know about their time there.
He is often able to give them a detailed account of their time at the station, and even show them key locations of where their relatives worked.


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As Omicron spreads rapidly, France records over 100,000 cases in 24 hours
This comes in as the Omicron variant is spreading at a very fast speed
In a record high, France for the first time recorded 104,611 Covid infections for the first time since the pandemic began. As per the authorities, cases in intensive care went up from 28 to 3,282. This comes in as the Omicron variant is spreading at a very fast speed, worrying the authorities.
To curb the spread of the virus, the authorities are considering bringing in the concept of vaccine pass. So far, 76.5 per cent of the population is fully vaccinated.
The vaccine pass will be valid only for those who have received a booster jab. The pass will be mandatory for access to cafes, restaurants and public spaces. It will also be required for international travel.
As of now, France has recorded 122,546 fatalities due to the deadly virus.
As Omicron variant torments healthcare, UK looks to hire foreign workers by relaxing visa rules
Meanwhile, the French Prime Minister had earlier warned that the new variant can become the dominant one in France from the start of 2022.
Jean Castex has warned people that if the people do not follow the basic Covid regulations, the Omicron variant may soon take over the whole nation.
However, he also added even though a lot is still unknown about this new variant, "it does not seem to be more dangerous than the Delta variant and the data available to us indicate that complete vaccination coverage with the booster dose protects well against severe forms of the disease".
He further added that the government will be taking extra measures to ensure that the problem of vaccine hesitancy is done away with.


If you listen to the headlines, this may appear to be a difficult time for lining up financing for the home you want to buy. But headlines can be deceiving. Burned by losses in sub-prime loans, banks have understandably tightened their requirements for creditworthiness. But there is, in fact, plenty of money available for qualified borrowers. And rates are historically low.
So don't let mortgage worries keep you from shopping for that home of your dreams. We can identify companies and loan officers who will help. It would be wise to seek our expert help to find the loan that is right for you. We deal with mortgage lenders every day so we know the reputations of local firms thoroughly.
Loan companies often have different standards for qualifying customers; some are willing to look at a less-than-perfect credit rating generously, while others are quite strict in that regard. A firm whose paperwork for granting a loan is extensive and time consuming may not fit your timeframe.
Sometimes lenders with low interest rates will have very stringent guidelines for underwriting loans. They may not make loans on certain kinds of property or be willing to deal with people who are marginally qualified.
We can discuss your needs and suggest several possible firms whose loan programs may be right for you.
The prospect of going to a lender and asking for your first mortgage can be a nerve-wracking experience. You may be concerned because you are new on the job or have not built up a strong credit history. Lending institutions are more concerned about your future ability to meet payments than what your past history showed. A secure job and future prospects will mean more to a lender than the fact that you've been a starving student for the past few years!
ADJUSTABLE RATE MORTGAGES - These start with a low introductory rate, then adjust to the prevailing rate at set intervals throughout the loan. They are attractive to new borrowers because monthly payments are low at the beginning, and it is hoped that rising salaries and home values will make later payments affordable. But as the current mortgage crisis demonstrates, hopes are sometimes dashed by reality.
GRADUATED PAYMENT MORTGAGES - Like Adjustables, the payments rise over time, but more predictably because the increased payments are predetermined.
FIXED RATE MORTGAGES - These are the safest loan instruments because the interest rate is set for the life of the loan. And rates these days are very attractive. Fixed Rate mortgages typically require better credit history and a higher down payment, but they are recommended for those you can qualify.
When you're figuring out how much you need to buy a home, don't simply add up the down payment and closing costs. You should also include incidental costs such as moving expenses and any repairs or refurbishing you may want to do. It's important to leave yourself a financial cushion to cover costs of this sort.
Some lenders stipulate that buyers must have such a cushion, equal to about two or three months of mortgage payments, set aside in a bank account. If you are putting down less than 10 percent on your house, this is very likely to be a condition of your mortgage loan.
When you take out a new mortgage you will undoubtedly be offered mortgage insurance. If you have only a small down payment, some lenders may require it in order to make the loan. Having your mortgage insured so as to provide a security for your family is a very basic part of estate planning.
Purchasing mortgage insurance is, like purchasing any kind of insurance, best researched. You may, in fact, be able to increase the amount of your present life insurance policy to cover the mortgage amount and have it cost you less than separate mortgage insurance. You should ask your insurance agent what they have to offer.
If you do choose to take the mortgage insurance that is offered, check what the policy covers. The policy may cover you only for accidental death or may only pay half of the mortgage in the event of the death of one of two joint owners. Ideally the insurance covers both owners. Dealing with the grief of losing a mate and also possibly the job of being a single parent is a tremendous burden. Having a home with no mortgage payment would not remove the grief but would decrease additional financial stress.


You are invited to join us for the Grand Opening of the Albright Parent Center. The Grand Opening is Tuesday, September 13th from 9AM-1PM. A light continental breakfast will be served. You will have the opportunity to meet our family liaison, Rachael Alspaugh, school principal, other school support team, as well as learn about all of the things we will offer in the center. We look forward to seeing you at Albright's Parent Center Grand Opening on Tuesday, September 13th from 9AM-1PM.
Parent Involvement Makes a Difference!
How can I become involved in my child's education?
Read together: Children who read at home with their parents perform better in school.
Use TV wisely: Limit the amount of TV viewing and watch and discuss shows with your children.
Establish a daily family routine: Make sure your child goes to school every day. Establish a regular time for homework. Routines may include chores, eating meals together, and a regular bedtime.
Talk with and listen to your children: Set a good example and listen to what your child has to say.
Keep in touch with the school: Stay informed about your child's progress at school. Visit the school or talk with teachers on the telephone.


AURO is a Multi-Discipline team of Highly Qualified Engineers, Experienced Technocrats and Dedicated Professionals from various fields.
AURO offers wide range of services i.e. Profit Maximisation, Process and Project Engineering, Different Value Based Technologies and Turnkey Plants.
AURO is into Process-Project Consultancy and provides Chemical, Pharma, Stevia & Herbal Extraction and CO2 Recovery Plants on Turnkey Basis with Technology Transfer.
We offer Technologies with Turnkey Plants for - Organic & Inorganic Chemicals, Speciality Chemicals, Phosgene Based Pharma Intermediates, Basic Drugs and Waste Recovery Plants.
In order to meet the present requirement of managing Industrial Wastes, we offer very innovative technologies for 'Turning Waste into Wealth' like - Recovery of 98% pure Barium Sulfate from Chlor-Alkali Plant waste sludge, Making Sodium Silicate & Amorphous Silica from Rice Husk Ash and many more.
We offer Technology for recovering Waste Carbon Dioxide from various Industrial Processes like - Fermentation Processes, Calcium Chloride, Magnesium Sulfate, Sodium Silicate Production Plants and Boiler flue gases and convert it into Food Grade Carbon Dioxide.
Stevia Extraction Technology - to make Stevioside, Rebaudioside-A powders and Liquid Extracts. Our Technology is registered with NRDC too.
Extracting Sodium Silicate / Amorphous Silica from Waste Rice Husk Ash with useful bye products Activated Carbon and Sodium Sulfate.
Recovery of 98% pure Barium Sulfate from Chlor-Alkali Waste Sludge. This quality Barium Sulfate has very good demand and it is being met by imports.
For making Anti-Ulcer Drug Sucralfate USP, it is being imported presently.
Important Pharma Intermediate - Triphenyl Phosphine. It has huge demand.
Triphogene Based Pharma Intermediates - Formats, Carbonates and Isocyanates.
Practical engineering, quality construction & single source of responsibility, AURO Associates offers unique benefits to its customers. These are critical virtues and not just fortunate alternatives.
The complete range of our services covers Process Engineering, Equipment Fabrication, Installation and Commissioning complete with documentation and on-site training of the operating personnel.
AUIRO Associates - AURO Associates is a Leading Process-Project Consultant in the field of Chemical, Pharma, Herbal and CO2 Recovery areas. Incepted in the year 2001 AURO has gained prominence and is now a Leading Chemical, Pharma, Herbal Extractions and Waste Recovery Project Consultants. AURO Associates is headed by its Founder CEO Mr. Sudhir Kumar.
APOORVA Herbals Pvt Ltd. - Apoorva Herbals is engaged in the Stevia Extraction and it uses Stevia Extraction Technology developed by AURO Associates. Apoorva Herbal''s Products are - Stevia Leaves, Stevia Leaves powder, Stevia Liquid Extracts, Stevia White Powders - Stevioside and Rebaudioside-A and they are marketed under its Brand Name Aurovia. Mr. Sudhir Kumar is Apoorva''s Managing Director.
AURO Associates is headed by its Founder CEO Mr. Sudhir Kumar. He obtained his Master's Degree in Chemical Engg. from Indian Institute Of Science, Bangalore, in the year 1969. He has vast experience of working with different Process Industries Mfg. Petrochemicals, Agro Chemicals, Dye-Intermediates and Pharma & Pharma Intermediates at various Senior Positions and was a Profit Centre Head for many reputed organizations.
APOORVA Herbals Pvt Ltd - It is headed by its Managing Director Mr. Sudhir Kumar. Apoorva is pioneer in the field of Stevia Extraction and its products - Stevia Leaves, Stevia Liquid Extract and Stevia Powder Extract are marketed under its Brand Name ''Aurovia''.


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Q: Oracle Materialized View - Fast Refresh and WHERE i have MV with code:
select id, name, flag from remote_table@dblink where flag = 1

it work, but if I want to get the flag column from the local table - the view returns a complex SQL error "cannot create a fast refresh materialized view from a complex query":
    select id, name, flag from remote_table@dblink
    where flag = (select val from local_table where id = 10)

How to complete the record limit based on the value from the database? So that the view could be created in fast mode?