Xiaomi Technology is facing increasing competition from rival vendors Oppo and Vivo in India's smartphone market, according China's tech.qq.com report. Xiaomi shipped over 10 million smartphones (16% of total smartphone volume) in India in 2016 and ranked as the second largest vendor in the market, trailing after Samsung. However, Xiaomi took the top spot for selling smartphones through online channels. In order to maintain its leading market position in India, Xiaomi is building a second handset plant in India in cooperation with Foxconn Electronics, the report noted. However, rivals Oppo and Vivo have also been expanding their share in India at a rapid pace by duplicating Xiaomi's business model, leveraging local factories, expanding online and offline retail channels, and building up brand image through advertisements, indicated the report. Combined share of Oppo and Vivo in the India market in the fourth quarter of 2016 was actually higher than that held by Xiaomi, said the report. Meanwhile, other China-based brands, including Lenovo, Meizu and One Plus, have also been gearing up their efforts to penetrate into the India market.


text:
Former KCU Trustee Terry Dunn, Peggy Dunn Named Nonprofit Connect's 2016 "Volunteers of the Year"
Nonprofit Connect, an organization that links the nonprofit community to education, resources and networking, has named Terry and Peggy Dunn its 2016 "Volunteers of the Year" for their far-reaching civic leadership and volunteerism. Mr. Dunn served on the Kansas City University of Medicine and Biosciences (KCU) Board of Trustees for two terms and was chairman from 2009 to 2013; he is currently the University's Centennial Campaign Co-Chair. Mrs. Dunn has served as mayor of Leawood, Kan., since 1997 and continues to work to positively impact the Kansas City community, including serving on the boards of the Leawood Chamber of Commerce, Truman Medical Center's Charitable Foundation and many more.
KCU and the University of Missouri – Kansas City (UMKC) Foundation jointly nominated the Dunns, who will be honored during Nonprofit Connect's 32nd Annual Philanthropy Awards Luncheon on Friday, May 20, at 11 a.m.
"It is an honor to recognize these individuals who have played such a pivotal role in our community," said Marc B. Hahn, DO, president and chief executive officer of KCU. "Their leadership has had a profound impact on this university, and has greatly influenced not only Kansas City, but also the states of Kansas and Missouri. Both Terry and Peggy embody our mission of improving the well-being of the communities we serve, and I can think of no two more deserving of this prestigious award."
In 2015, UMKC awarded Mr. and Mrs. Dunn — both alumni of the university — its top honor for volunteerism, the Chancellor's Medal.
"The choice of Terry and Peggy Dunn for this award is so appropriate and well-deserved," said UMKC Foundation President Steven P. Norris. "The impact they have made on Kansas City over the years has been profound. Both Terry and Peggy are UMKC alumni and have been extensively involved with the university for years, and they have made a significant difference for us and our ability to serve our students and our community."
Score 1 for Health Receives Rave Reviews from Students of SVN
Students of SVN experienced life at KCU with health screenings and fun STEM activities.
Dr. Rex Archer Joins KCU as Professor and Director of Population and Public Health
KCU is pleased to announce the appointment of Rex Archer, MD, MPH, as Professor and Director of...
KCU to Cut Ribbon on New Medical School with Focus on Primary Care in Rural Areas
Leaders from Kansas City University of Medicine and Biosciences (KCU) will join partners and...

redpajama_set_name: RedPajamaCommonCrawl


text:
A Laval-fúvóka egy középső részén összeszűkülő, homokóra-üveg formát felvevő csőszakasz. Arra használják, hogy összenyomható gáz áramlási sebességét megnöveljék. Bizonyos típusait széles körben használják gőzturbinákban és fontos része a modern rakétahajtóművelnek.

A fúvókát Gustaf de Laval svéd mérnök találta fel a 19. században és használta először forradalmian új gőzturbinájában. Kis sebességeknél a gáz az összenyomhatatlan folyadékokhoz hasonlóan viselkedik. Ilyenkor az áramlási sebesség növelésére csökkenő keresztmetszetű fúvókát kell használni, ahogy ez a folytonosság törvényéből következik. Az áramlási sebesség és a nyomás közötti összefüggést Bernoulli törvénye írja le. Ha a sebességet növeljük, a gáz összenyomhatóságát annál is kevésbé lehet már elhanyagolni, minél jobban megközelíti a hangsebességet (minél nagyobb a Mach-szám). Ekkor is igaz azonban, hogy a keresztmetszet szűkítésével nő az áramlási sebesség, de az összefüggéseket már az energia egyenlettel lehet követni.  A gáz állapotváltozása a Laval-fúvókában történő áramlása során jó közelítéssel izentropikus (a gáz entrópiája közel állandó) és adiabatikus (a hőveszteség vagy -nyereség a környezet felé közel zéró). Amint azonban a gáz áramlási sebessége eléri a hangsebességet, további sebességnövekedést csak a keresztmetszet újbóli bővülésével lehet elérni. Ennek oka a gáz rohamosan növekvő térfogatában keresendő.

Szubszonikus áramlás esetén ha az áramlást meghatározó mennyiségekben valami változás áll be (például lecsökken a fúvóka utáni nyomás), ez a gázon tovafutó hang, azaz egy kis nyomáshullám formájában terjed tovább és az egész áramlás átáll az új feltételeknek megfelelően. Ha a fúvóka előtti és utáni nyomás viszonyát növelik, egy meghatározott érték elérésekor a fúvóka "torka" közelében, ahol a keresztmetszet a legkisebb, a gázsebesség helyileg transzszonikus lesz (a sebesség eléri a hang sebességét, a Mach-szám = 1,0). Ennél a pontnál a fúvóka utáni változás nem képes visszahatni a torok előtti áramlásra, mert a hanghullámok nem képesek visszafelé haladni, mivel a gázsebesség nagyobb a hangénál, azaz a gáz sebessége szuperszonikus (Mach-szám > 1,0). Ezért az időegység alatt kiáramló gázmennyiség az ellennyomás csökkenése ellenére is állandó marad. Ha a torok után a keresztmetszet ismét bővül, a gáz kitágulhat, az expanzió felgyorsítja a gáz kiáramlási sebességét.

Gáz áramlása fúvókában
Az összenyomható ideális gázra a kinetikus energia és az entalpia összege az energiamegmaradás törvényéből következően állandó. Így egy tartályból kiáramló gázra írható:
,
ahol
 a gáz entalpiája,
 a gáz sebessége,
 a belépésnél mért mennyiségek indexe,
 a fúvóka egy tetszőleges pontján mért mennyiségek indexe.
Mivel a gáz belépésnél mérhető mozgási energiája elhanyagolható a kilépő gázéhoz képest, közelítőleg írható:

Felhasználva azt, hogy ideális gázok entalpiája kifejezhető az abszolút hőmérséklettel és az állandó nyomás melletti fajhővel:
,
valamint az R egyetemes gázállandó és a κ adiabatikus kitevő alábbi összefüggéseit:
 = 8314,5 J/(kmol·K)
és

a gáz sebességére a fúvóka egy tetszőleges pontján a következő összefüggés kapható:

A gáz egységnyi idő alatt átáramló tömege:

ahol
 a fúvóka keresztmetszete,
 a gáz sűrűsége a belépésnél,
 pedig a kiáramlási függvény, melynek változását a mellékelt diagram mutatja. A grafikonnak a szaggatott vonallal jelölt része nem érvényes a tapasztalatok tanúsága szerint.

A kritikus nyomásviszony vagy Laval-nyomásviszony:

Levezethető a gázegyenletekből némi átalakítás után, hogy a kritikus nyomásviszony helyén a kiáramló gáz sebessége éppen a hangsebességgel egyenlő.

Laval észrevette, hogy a kiáramlási sebesség csak úgy növelhető, ha attól a helytől kezdve, ahol a fúvókában a gáz sebessége eléri a hangsebességet, a keresztmetszetet fokozatosan növeli.

A Laval-fúvóka üzeme
Megadott pb beömlő és pt ellennyomásra és adott tömegáramra meghatározható a gázegyenletek és a folytonosság alapján a fúvóka kiömlő keresztmetszete. A legnagyobb kiömlő sebességet adott beömlő nyomás esetén akkor lehet elérni, ha a kiömlés vákuumba történik (pt=0), azonban ilyen állapot gyakorlatilag nem elérhető, mivel a kiömlő keresztmetszetnek végtelen nagynak kellene lennie.

Ha a Laval-fúvóka a tervezési nyomások mellett üzemel, akkor a nyomás és sebesség lefolyása a fúvóka hossza mentén a diagram piros görbéje szerint alakul. A fúvóka torokkeresztmetszetében (a legszűkebb helyen) kialakul a hangsebesség, majd a sebesség tovább nő a kilépésig. Ha az ellennyomás csak kicsivel kisebb a beömlésnél mérhető nyomásnál, a két érték a kék görbe szerint alakul, a nyomás nem éri el a kritikus értéket a toroknál és a hangsebesség sem alakul ki. A zöld görbe azt az esetet mutatja, ha az ellennyomás a tervezett értéknél magasabb, de a toroknál már fellép a hangsebesség (M=1). Ekkor a görbe egy darabig a piros görbével együtt halad, majd egy ponton hirtelen nyomásnövekedés figyelhető meg.

A fekete görbe azt a határesetet mutatja, melynél az ellennyomás éppen akkora, hogy a toroknál a hangsebesség kialakul. Nincs ábrázolva az az eset, amikor az ellennyomás a tervezettnél is kisebb, ekkor a kilépésig a piros görbe érvényes, a kilépés után hirtelen expanzió lép fel.

Egy űrrakéta esetén mindezek a tervezett és attól eltérő üzemviszonyok előállnak, hiszen előrehaladása során a levegő nyomása állandóan csökken. Indításnál a levegő nyomása (a kilépési nyomás) a tervezettnél nagyobb, így a folyamat a zöld görbe szerint zajlik: a kiömlési sebesség az optimálishoz képest kisebb, az áramlás a fúvóka belsejében leválik és nyomáslökéssel lép ki.
Amint a rakéta emelkedik, a légköri nyomás csökken, így a kilépő gázsebesség nő, a rakéta tolóereje növekszik. Ha a rakéta olyan magasságba emelkedik, ahol a levegő nyomása már kisebb a tervezettnél, a fúvókából kiáramló gáz hirtelen expanzióval távozik a fúvókából.

A valóságos fúvókák viselkedése a számítotthoz képest eltér. Egyrészt a gáz belső súrlódása és a környezet felé leadott hője módosítja az energiaegyenlet egyszerű összefüggését, másrészt a fúvóka keresztmetszetének bővülése miatt az áramlás térbeli voltát nem lehet elhanyagolni. Hogy ennek hatását csökkentsék, a rakétahajtóművek fúvókáinak kúposságát a kilépés felé igyekeznek csökkenteni, mert a gáz sebesség radiális komponense nem járul hozzá a tolóerő növeléséhez, így veszteségnek számít.

Alkalmazás

A Laval-fúvókát feltalálója először az első gőzturbinákban alkalmazta. Laval akciós turbinát szerkesztett, melyeknél a vízgőz entalpiáját teljes egészében mozgási energiává alakította, sebessége meghaladta a hangsebességet, ezért volt szükség szűkülő-bövülő fúvóka beépítésére. Hasonló célokra ma is használják megoldását.

A rakétamotorok annál hatékonyabbak, minél nagyobb sebességre tudják gyorsítani a kiáramló égéstermékeket. Ezért minden rakéta egyik legfontosabb alkatrésze a Laval-fúvóka.

Legyen egy rakéta Laval-fúvókáján átáramló forró levegő kezdeti nyomása 6,9 MPa, a hőmérséklete 1470 K és a kilépésnél a nyomás 0,1 MPa, ekkor a torokban a nyomás 3,7 MPa, a hőmérséklet 1269 K, a kilépési hőmérséklet pedig 502 K lesz. Az expanziós viszony, vagyis a kilépési keresztmetszet és a torok keresztmetszetének hányadosa 6,8. A fajlagos impulzus ekkor 151 s (1480 N·s/kg).

Különböző hajtóanyagú rakétahajtóművek jellemző  kilépő sebessége:

 1,7 - 2,9 km/s egykomponensű folyékony hajtóanyagnál
 2,9 - 4,5 km/s kétkomponensű folyékony hajtóanyagnál
 2,1 - 3,2 km/s szilárd hajtóanyagnál

Irodalom
 Pattantyús: Gépész- és villamosmérnökök kézikönyve 2. kötet. Műszaki Könyvkiadó, Budapest, 1961

További információk
 dr. Pokorádi László: Áramlástan. Főiskolai jegyzet
 Lengyel Lajos: Gázdinamika. Egyetemi jegyzet
 Oktatás mindenkinek - Áramlástan, 20. fejezet: A Laval-fúvóka
 Fúvóka applet
 S.M.Yahya: Fundamentals of Compressible Flow with Aircraft and Rocket Propulsion
  Fundamentals of CompressibleFluid Mechanics Genick Bar–Meir, Ph. D.: Fundamentals of CompressibleFluid Mechanics

Áramlástechnika
Energetika

es:Tobera#Tobera De Laval

redpajama_set_name: RedPajamaWikipedia


○■ even those of you who repair old antique tube radios, t.v.'s, & even the more complex ham radios / receivers (especially from 1918-1965) such as philco, rca, admiral, zenith, hallicrafters, sears, brewster, crosley, firestone, plus hundreds more!!
○■ you must drink as you have brewed.
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Like many people's basements Joe and Sarah's lower level was nothing to write home about. The space was damp, musty and dark and the rooms were cut off from one another. Basically the basement was a place to store stuff…but nothing too valuable due to the dampness problem.
The Bedroom – Sliding barn doors which not only could tame a tiger..but a Bengal as well! – I love the sliding barn doors in this Cincinnati Bengal themed room (note the back wall artistry was done by Joe Chaulk– although I have to admit I think it would look better with the Cleveland Browns logo!). The canned lights and wood wainscoting make the space inviting with the warm feeling of a rustic lodge.
The Bathroom – Mashing up warmth, low maintenance products and fun use of color.
Warmth – Entering this room I could feel the warmth of the wood patterned ceramic floor and wall tiles and furniture grade cabinetry. Sarah decided on a 6" x 24" ceramic plank floor from the "Natura" series from Florida Tile with a slightly distressed wood grain. A furniture grade marble top vanity from Austell provides a contemporary and sophisticated look.
Low maintenance – The glass block walk in shower with rounded edges on the top and sides (which was installed by the Columbus Glass Block division of Innovate Building Solutions) is not only easy to maintain, but also provides an open feeling to the bathroom. The thinner glass blocks help to maximize the space on the inside of the shower as well.
Fun use of color – As Sarah said, "Why not have some fun with the decorating?" The use of the green Amazing Hulk picture really pops and captures the spirit of the Chaulk family to enjoy life.
"The hand" – No this is not a replica of "The Thing" from the Munster Family …but it is close. When you come down the basement banister you can reach out and find a seasonal ball or piece of memorabilia from one of the Chaulk's favorite teams placed in this "decorative hand." Right now "the hand" is featuring a Butler University Bulldogs football.
A piece of Shea Stadium – This fun Shea Stadium scoreboard piece is historically interesting and will eventually be surrounded with other New York imagery.
Coming soon…. A "rod hockey game" – This brought me back to my childhood. Joe has on order a rod hockey game with the spinning rods – I hope I get an invitation back to play!
What feature do you like best in this family oriented basement remodel? Please comment below or call for a free design consultation on a glass block shower wall or windows or a Cleveland basement remodeling project.
For glass block showers or windows call Innovate Building Solutions on a nationwide basis (877-668-5888) or for a local project their divisions including Columbus Glass Block (614-252-5888), Cleveland Glass Block (216-531-6363), West Side Glass Block (216-398-1020) or Mid America Glass Block in Akron (330-633-2900). For a basement remodeling project in Cleveland – contact Cleveland Design and Remodeling (216-658-1270).


text:
Resultados do Grande Prêmio dos Países Baixos de Fórmula 1 realizado em Zandvoort em 27 de agosto de 1978. Décima terceira etapa da temporada, teve como vencedor o norte-americano Mario Andretti, que subiu ao pódio junto a Ronnie Peterson numa dobradinha da Lotus-Ford, com Niki Lauda em terceiro pela Brabham-Alfa Romeo.

Resumo
Última dobradinha da Lotus na primeira fila do grid até o Grande Prêmio de Dallas de 1984

Mario Andretti conquistou a última vitória de sua carreira, bem como a última vitória de um piloto norte-americano na categoria, marca ainda vigente em 2019.

Última corrida e último pódio de Ronnie Peterson antes de seu fatídico acidente em Monza, Itália, duas semanas depois.

Graças a esta dobradinha (aliás, a última na história do time) a Lotus restringiu a disputa pelo título mundial apenas aos seus pilotos, configurando mais um título de construtores em sua coleção.

Classificação da prova

Tabela do campeonato após a corrida

Classificação do mundial de pilotos

Classificação do mundial de construtores

 Nota: Somente as primeiras cinco posições estão listadas. As dezesseis etapas de 1978 foram divididas em dois blocos de oito e neles cada piloto podia computar sete resultados válidos. Dentre os construtores era atribuída apenas a melhor pontuação de cada equipe por prova e a campeã mundial surge grafada em negrito.

Países Baixos
Desporto nos Países Baixos em 1978
1978


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Remember to come and have a look at our latest hobo jack UK collection on 27th March.
The feel for this colection is very rustic and will incorporate a lot of hand drawn and written pieces that will be put together with the classic hobo jack style.
It will have a woodland and bushcraft feel and will be based around nature and the heartland.


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Getting the most from your ecommerce website design can be tricky, but the simple fact is that you need to run your online store much in the same way you would a public-facing storefront. What are the best ways to encourage purchases? How can you encourage your visitors to spend more each time they shop? There are many online marketing strategies you can use – however, as experts in Magento ecommerce, we know the tricks of the trade – here are five of them to help you get started.
This one works well both in real life and online – by placing certain products in people's eye line, they will be more drawn to purchasing them. Amazon and eBay do this to great effect – after ordering an item or placing one in your basket, you may be approached with the opportunity to buy 'similar' items. By grouping your products together and by encouraging your customers to look into additional items before they checkout, you could really drive up your average order value.
Offering free shipping will only help to increase your average order value if you set it above a certain rate. For example, encourage your buyers to buy over £50 of items to qualify – if a customer is looking to spend £45 on any given day, for example, they may be encouraged to spend that little bit more to get free shipping. This is one of the most popular online marketing strategies, and should therefore be one you consider early on in your ecommerce website design.
As experts in Magento ecommerce, we know only too well that certain packages and certain rates do better than others. This is all the more reason to consider package deals – will certain items go well with others? Can you offer a slight discount that won't impact on your sales figures? Amazon already offers this to great effect – it's another form of upwelling that helps customers find similar products or linked items.
Limited deals are a great idea if you're running a storefront and are keen to encourage customers to buy now rather than later. This technique can be used to encourage buyers to take advantage of, for example, 50% off certain lines for three days – meaning that they will be more likely to increase their shopping cart value in a short period of time. Get them while they're hot!
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For more information on making ecommerce work for you and to get the most out of Magento ecommerce, contact Vital Concept today! Please call or email and we will be back in touch with you as soon as possible.


text:
Fall 2019 /
Cyber education: evolving tools for evolving threats /
Priming for cyber combat
Current page: Cyber education: evolving tools for evolving threats
Loan lessons with real stakes
When the biggest threat is you: privacy risks of uninformed users
Business analytics: predictive modeling of ER overcrowding
Jin Xu wins Best Paper Award for research showing tax benefit of debt financing
Sarah Stein wins Best Paper Award for learning resource on analytics
By the numbers: national rankings
Inaugural Pamplin Engagement Summit
Finance Ph.D. alums gather in memory
Visiting Carilion Clinic's command center
Kicking it up with fellow Hokies
Celebrating Pamplin's international community
Business analytics ventures out
Discovering Chinese business and culture
Inaugural conference on thought leadership
Students study abroad in the Dominican Republic
Black alumni network
Back-to-school picnic
MBAs explore Scandinavia
University awards
Digital defenders: meeting the need for talent, bridging the business-technology gap
Cyber education: evolving tools for evolving threats
Baback Bazri is a partner in the government and public sector advisory services practice at Ernst & Young LLP, in McLean, Virginia. (Photo credit: Mike Guirguis/EY)
Having grown up in a close-knit Northern Virginia family, Baback Bazri (BIT '04) had no doubt that he would attend an in-state college.
Choosing Virginia Tech was easy. The deal was sealed during a campus visit on a beautiful fall weekend. "I could feel the energy on campus, and all the facilities were top-notch," said Bazri.
But the road to Pamplin was not quite as straightforward.
"I was actually accepted into the College of Engineering, but after a few semesters, I knew engineering was not for me," said Bazri.
He had always been interested in technology and how information systems interconnected with one another to solve real-world problems. "Once I switched to Pamplin and started taking core courses and business information technology classes, it all clicked for me," he said.
Prioritizing cybersecurity
Bazri, a partner in the government and public sector advisory services practice at Ernst & Young LLP, located in McLean, Virginia, has served a wide array of federal government agencies as well as Fortune 500 organizations in financial services, professional services, retail, telecommunications, and wholesale distribution.
One of the most important things Bazri says he learned as a student is how to work on teams and bring diverse sets of people together to solve problems. (Photo credit: Mike Guirguis/EY)
He has led cyber security and information assurance engagements both in program management and technical disciplines, as well as cyber strategy, cyber risk management, audit readiness, and financial statement audit. He is a Certified Information Systems Security Professional and Certified Information Systems Auditor.
At the start of his career 15 years ago, Bazri said that businesses were focused on protecting the vast array of what were primarily legacy systems. "Today, the 'internet of things' and other smart devices inundate the workplace and our personal lives, driving concerns about cybersecurity right to the top of business agendas," he said.
While he said it is generally best to prioritize cyber spending and controls around highest value assets, there are no cookie cutter answers to many cyber security concerns.
"No challenge or day is the same as the last in this fast-paced industry. I wake up every morning thinking about client service and what innovative solutions can help solve my client's most complex problems," Bazri said.
Diverse approaches
Throughout his career, Bazri said, he has had many mentors, coaches, and sponsors who have helped him achieve his professional goals. "This has made me passionate about paying forward to younger professionals."
The help he received from many mentors, coaches, and sponsors has made Bazri "passionate about paying forward to younger professionals." (Photo credit: Mike Guirguis/EY)
Bazri said he is also committed to giving back to Pamplin for the essential role the college has played in his success.
One of the most important things he learned as a student was how to work on teams and bring diverse sets of people together to solve problems. "Having challenging discussions and healthy conflict to ultimately achieve the best outcome for the problem you are trying to solve was not only a good model for class projects, but has been applicable to my career," said Bazri.
And advice from one of his former management professors, Christopher Neck — to be goal-oriented and continually challenge yourself — guides him to this day.
To this guidance, Bazri has added some recommendations of his own for Pamplin students and recent graduates entering the cybersecurity field: "Your passion for learning needs to continue after you leave Pamplin. Digital technologies are evolving rapidly as are cybersecurity threats, so you have to invest in your career, and stay current with trends in the marketplace. What you learn at Pamplin gives you all of the tools you need to succeed, but staying current in your field, being open to new experiences, and being flexible and agile in the workplace are key to sustaining success as you challenge yourself to take on new opportunities."
Bazri has served on Pamplin's business information technology advisory board since 2017. "Being on the board provides unique insight into big changes taking place for the university, Pamplin, and the department, so any little part I can do in shaping the future of the university is both exciting and humbling at the same time," he said.
Also committed to public service, he is a member of the audit committee of Child Care Aware of America, a national, nonprofit organization working to advance child care affordability and accessibility, and the development and learning of children in child care. He has provided financial planning seminars to underserved youth in the Northern Virginia area.
Bazri spends most of his leisure time with his wife, Lauren, and their two daughters, Roya, 4, and Tala, 1, whom he enjoys chauffeuring to their various activities.
He is "a huge sports fan of the Hokies and all Washington, D.C., sports teams." Last year, he took Roya on a daddy/daughter weekend to her first Hokie football game. "We are planning to make it a tradition and will be heading down for another game this fall," Bazri said.


Specify the output .o file. Default is pre_rpl.o.
Specify the output .a file.
Specify the name of the final RPL/RPX.
Emit a text log to the specified file.
Export symbols specified in <file> (text, extension optional).
Export all global non-weak loadable symbols. Not recommended; use rplexportall instead.
Exclude symbols specified in <file> (text, extension optional).
Do not generate library header.
Insert <file> in the command line.
List of object files which are also passed to the linker. Optional when using -x <file> -r <rpl-name> -l <file>.
Deprecated. Pass this option to makerpl[32|64] if desired.
When passed, static initializers are allowed as exports with warning. Default: attempt to export a static initializer is an error.
When passed, symbols in linkonce sections are allowed as exports with warning. Default: attempt to export a linkonce symbol is an error.
This Windows tool is provided in two flavors: preprpl32.exe and preprpl64.exe, for 32-bit and 64-bit operating systems, respectively.
preprpl[32|64] is called before linking. It generates an object (.o) file which must then be passed to the linker.
Optionally, preprpl[32|64] can generate an import library (.a) to which other modules can link.
The tool preprpl[32|64] streamlines the build process by generating the export object file (.o) and the import library file (.a) from an export definition file (via the "-x <file>" option).
The "pre-v1.0" method of invoking preprpl[32|64] with the same file list that is provided to the linker is still supported. In this mode, all application object files and system object files (such as coredyn.a, mtx.a, etc) must be passed to preprpl[32|64].
Nintendo strongly suggests that you do not export static initializers and linkonce symbols.
As of SDK 2.11.03, rplexportall and preprpl[32|64] have been modified to exclude static initializers and linkonce symbols because these symbols can cause problems if they are exported. You can read more information about linkonce symbols in the GHS documentation (see $GHS_ROOT/manuals/build_ppc.pdf). Static initializers are a problem because static initializers from a RPL will become imported if any other symbol from that RPL is imported. This could cause the static initializer to be recalled for every RPL that imports the static initializer.
Perhaps upon examination of your situation that you can determine that you want these exclusions. If so, you can manually add them back into your exports.def file and pass one or both of the new preprpl[32|64] options to allow them to be added to your RPL's exports (-warnsti and -warnlinkonce). However, we consider that these new options should only be used as a last resort.
If you have a static initializer and you want to remove it from your exports, see Removing a Static Initializer from the Exports.
Contact your local Nintendo developer support group for advice if you are unable to dispense with these symbols due to backward compatibility issues.
The following descriptions reference the Examplemake demo package. The package demonstrates various aspects of the build system, including the latest RPL tool enhancements. The version of Examplemake included in the SDK is compatible with the current SDK. For comparison with older SDK versions, obtain the Examplemake package from your local Nintendo developer support group.
When building RPX and RPL files, you export the symbols that other modules wish to access.
Consider the Examplemake demo program helloworld_rpl. In this example, the primary application hello.rpx is loaded first. The application implicitly loads (or "acquires") the RPL world.rpl.
All modules export symbols. The exported symbols are specified in the hello.def and world.def export definition files.
The build process for each component invokes preprpl[32|64] before linking, and generates a .o file and a .a file. The .o file contains exported symbol information, making the symbols accessible to other RPX and RPL modules. The .a file contains import symbol information, used by other RPX and RPL modules to reference the exported symbols.
Only global, non-weak, data and functions may be exported.
The -x <file> option can be used with the -r <rpl-name> and the -l <rpl_name.a> arguments to generate an export object .o and an import library .a. By this method, preprpl[32|64] does not require any object files.
This is the method used in the helloworld_rpl demo. See the hello.def or world.def files in the demo for more information.
The default file extension for the <file> argument is .def.
The -x <file> option will only export symbols listed in the specified text file. This is the method used in the helloworld_rpl demo. For information, see the hello.def or world.def files in the demo.
The -xall option will export all global, non-weak symbols from all listed .o files. While not generally useful, this method may be the most viable for C++ applications given the mangling of symbol names at link-time.
The -xnot <file> option will exclude the symbols listed in the specified text file.
If you use the -xall option for an RPX, you may inadvertently export a symbol that conflicts with a symbol from an RPL. To resolve this, you can exclude the conflicting symbol using -xnot <file> for the RPX.
Examine the static initializer name, for example __sti___10_foobar_cpp_f5d9abb2. This static initializer is in the source file foobar.cpp. Also, all of the characters are legal C language characters.
Change the name of the source file. For example, change it to foobar_fixed.cpp. This will rename your static initializer; make sure it does not get exported.
Create a new C file. For example, call it phony_initializer.c. Make it C to avoid warnings from MULTI if you use C++.
Create an extern "C" function with the old static initializer name and have it do nothing.
Add the old static initializer to your exports file.
If you are using SDK 2.11.03, pass the -warnsti option to preprpl.
Recompile your module's sources and relink. Any module that imported the old static initializer will now call the version in phony_initializer.c and will not reinitialize your class objects.
Exporting and importing symbols simultaneously between two modules is supported. For more information, see the notes on RPX/RPL Cross-Referencing.
The Examplemake demo program helloworld_rpl illustrates how to create RPX and RPL modules using preprpl[32|64]. For convenience, we will use the definitions below to describe the various parameters for building the example.
There are no major differences between the preparation of an RPX versus an RPL.
2013/12/13 New exclusions from preprpl[32|64].
2012/07/23 Removed references to old SDKs. Updated Examplemake references.


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NDnano Seminar: "A Magnetic 'Spin' on Nanomedicine"
Time: Tue Mar 3, 2015, 1:00PM - 2:00PM
Presented by Prof. Sakhrat Khizroev, Florida International University
Professor of Cellular Biology & Pharmacology, Herbert Wertheim College of Medicine
Professor of Electrical & Computer Engineering, College of Engineering & Computing
Abstract: The emerging field of personalized nanomedicine promises unprecedented patient- and disease-specific medical diagnostic and treatment. Significant progress has been achieved in this field from the perspective of biotechnology. With the development of bioinformatics, there are endless computational resources and chemical databases to identify a molecular compound tailored to almost any biomarker. Conversely, the development of high technology to treat a disease at a fundamental single-molecule level is still in its very early stage. Such a technology-driven approach could significantly benefit from understanding the physics of nanomagnetics to enable a high-efficacy external-field control of intrinsic molecular processes that underlie specific diseases. Being complementary to the conventional approach, the new development can make its own special contribution to the big goal of making personalized nanomedicine a reality. This presentation will discuss our recent studies on using magneto-electric nanoparticles to advance the state of treatment of cancer, HIV/AIDs, and other diseases. The promising results of in-vitro and animal studies on mice will be presented to demonstrate the novel nanotechnology.
Bio: Sakhrat Khizroev, a professor with a joint appointment in the College of Engineering and the College of Medicine, is an inventor with expertise in nanomagnetic/spintronic devices. His group's current research focus is at the intersection of nanotechnology and medicine. His research team works hand-in-hand with leading medical researchers and clinicians to advance the state of the art in areas of oncology, HIV/AIDs, neurodegenerative diseases, ophthalmology, and others. Prior to re-joining FIU in 2011 to lead the university-wide multi-disciplinary research effort in personalized nanomedicine, Khizroev was a tenured faculty (professor from 2009-2011 and associate professor from 2006-2008) at the department of electrical engineering of the University of California, Riverside (UCR). From 2003-2005, he was associate professor of electrical engineering at FIU, where he was tenured in 2005. Prior to his academic career, Khizroev spent almost four years as a research staff member with Seagate Research (1999-2003) and one year as a doctoral intern with IBM Almaden Research Center (1997-1998). For his pioneering contribution to the development of perpendicular magnetic recording (PMR), the current main technology in the multi-billion-dollar data storage industry, and other discoveries in the broad area of spin-based nanodevices, Khizroev was named a Fellow of National Academy of Inventors (2012). He holds over 30 granted US patents plus many international patents. He has authored over 120 peer-reviewed papers, and has acted as a guest science and technology commentator on television and radio programs across the globe. He has served as an editor for IEEE Transactions on Nanotechnology, Nanotechnology, and IEEE Transactions on Magnetics. Khizroev received a B.S/M.S. degree in physics from Moscow Institute of Physics and Technology in 1992/1994, a M.S. degree in physics from the University of Miami in 1994, and a PhD in electrical and computer engineering from Carnegie Mellon University in 1999.
Hosts: Prof. Wolfgang Porod and Prof. Gary Bernstein, Electrical Engineering


text:
Gunnar Hansen
Cause of death Pancreatic cancer
Name Gunnar Hansen
Years active 1973–2014
Occupation Actor
Height 1.93 m
Full Name Gunnar Milton Hansen
Born March 4, 1947 (1947-03-04) Reykjavik, Iceland
Alma mater University of Texas at Austin
Died November 7, 2015, Northeast Harbor, Maine, United States
Books Chain Saw Confidential, Islands at the edge of time
Education University of Texas at Austin, Stephen F. Austin High School
Movies The Texas Chain Saw Massacre, Hollywood Chainsaw Hookers, Reykjavik Whale Watching, Mosquito, Chainsaw Sally
Similar People Tobe Hooper, Marilyn Burns, Andrew Bryniarski, Edwin Neal, Ed Gein
Actor gunnar hansen leatherface has died
Gunnar Milton Hansen (March 4, 1947 – November 7, 2015) was an Icelandic-born American actor and author best known for playing the mentally impaired cannibal Leatherface in The Texas Chain Saw Massacre (1974).
Gunnar hansen 1947 2015
As self
Hansen was born in Reykjavík, Iceland, and moved to the United States when he was five years old. He lived in Maine until age eleven, when his family moved to Austin, Texas, where he attended both Austin High School and the University of Texas at Austin. He majored in English and mathematics as an undergraduate and then went to graduate school in Scandinavian Studies and English.
His first job out of high school was as a computer operator before he began theater work during college. He was also a football player during high school and for a while a bar bouncer. In 1973, just after finishing graduate school, Hansen heard that The Texas Chain Saw Massacre was being filmed in Austin and decided to try out. He got the part of Leatherface, the masked killer in the movie. Hansen apparently visited and studied children with special needs to determine mannerisms for Leatherface.
After the success of the movie, Hansen co-starred in Demon Lover, but after the experience he decided not to continue acting, instead pursuing a writing career. In 1975, after one extra year of graduate school, Hansen moved back to Maine and started writing. During this time he rejected a part he was offered in the cult horror film The Hills Have Eyes.
After writing (and occasionally editing) for magazines and writing books, Hansen returned to acting in 1988, appearing in the horror spoof Hollywood Chainsaw Hookers, and appeared in 20 films since. He considered his later acting as a side project and continued to write books. He also wrote film scripts and wrote and directed documentary films.
Hansen was also an author; his nonfiction travel memoir, Islands at the Edge of Time, A journey to America's Barrier Islands, was published in 1993. In 2013 he wrote the nonfiction book Chain Saw Confidential, which focuses on the making and reception for The Texas Chain Saw Massacre. In addition, he taught college as an adjunct instructor.
His agent stated Hansen died at his home in Northeast Harbor, Maine from pancreatic cancer on November 7, 2015 at the age of 68.
Terror in the Aisles (1984) – archival footage
Texas Chainsaw Massacre: A Family Portrait (1988)
Texas Chainsaw Massacre: The Shocking Truth (2000)
Leatherface Speaks: An Informal Interview with Gunnar Hansen (2001)
Behind the Attic Door: The Making of "Rachel's Attic" (2002)
UnConventional (2004)
Flesh Wounds: Seven Stories of the Saw (2006)
Gunnar Hansen Wikipedia
Similar TopicsAndrew Bryniarski
Edwin Neal
Andrew Bryniarski


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Ontario Police Report More Than 340 Motorcycle Deaths in Past Decade
Posted on behalf of Greg Monforton & Partners Injury Lawyers on May 6, 2022 in Motorcycle Accidents
Following the start of Motorcycle Awareness month 2022, the Ontario Provincial Police (OPP) have released a new report examining motorcycle crash data between 2012 and 2021.
During that decade, the OPP responded to 326 fatal motorcycle crashes. Those crashes resulted in the deaths of 342 motorcyclists.
By taking a closer look at this data, the OPP hope it may help to reduce the number of fatal crashes in the future.
Motorcyclists At Fault in 60.7 Percent of the Fatal Crashes
According to a report in the Blackburn News, the OPP examined the cumulative data from all of the fatal motorcycle crashes from the last decade to learn more about who was responsible. That report revealed that 60.7 percent of the time, the motorcyclists who died in the crash were also the at-fault driver.
In 39.3 percent of these crashes, drivers of other vehicles were determined to be at fault.
Other relevant details revealed about these motorcycle crashes from the last decade include:
120 of these fatal collisions involved a single motorcycle
The other fatal crashes, causing 222 more deaths, had at least one other vehicle involved
Percentage-wise, most riders in these fatal crashes were between the ages of 45 and 54
What Were the Leading Causes of These Crashes?
The leading causes of these fatal motorcycle crashes from the past decade are not unexpected or new. The ongoing and primary contributing factors of deadly motorcycle crashes each year are:
Excessive speeding
Failing to yield the right of way
Driver distraction/not paying attention to the road
Road Safety is the Responsibility of Every Driver
The OPP reminds motorcyclists and drivers that road safety is everyone's duty and includes:
Sharing the road responsibly
Following posted speed limits
Not driving while impaired by alcohol or other substances
Not engaging in dangerous distracted driving behaviour
Unfortunately, because of the inherent vulnerability of those who ride a motorcycle, there is zero room for driving errors. This means remaining watchful for potential hazards, including sudden weather changes that could affect road safety.
If you are a newer motorcycle rider, or even one with years of experience, the OPP encourages you to read/review these motorcycle safety tips.
Injured in a Crash? Contact Our Trusted Legal Team Today
If you were injured in a motorcycle crash, you may be eligible to seek compensation for your damages.
Contact the legal team at Greg Monforton and Partners to learn about your legal options and get answers to your questions. Our Windsor car crash lawyers are experienced and ready to help.
Call to schedule your completely FREE case review today. There is no obligation to hire our services after this meeting and no upfront costs if we represent you.
Proven Results. 866-320-4770
Motorcycle Accidents News
Motorcyclist in Hospital Following Thursday Afternoon Crash on Tecumseh Road
Stretch of Riverside Drive West Has Been Reopened After Accident
Motorcycle Crash in South Walkerville Causes Critical Injuries


Whether you are purchasing your first vehicle or finally buying that motorcycle you had your eye on, the Firefighters and Company Federal Credit Union has the rates and terms you want, to make it a sweet ride. With our Auto Buying Service, Auto Link, you can research your new vehicle and get the best price and so much more!
Interest rates are subject to type of loan, credit score and terms. All rates are subject to change. Other conditions may apply. Qualified Vehicles are 8 model years or newer and/or 100,000 miles or less. The model year of the vehicle, loan amount and credit score may affect term and rate.
New and Used Recreational Loans can be used to purchase or refinance qualified vehicles (8 model years or newer). Recreational vehicles are boats, RVs, motor homes, travel trailers. ATVs, etc.


Star Wars has The Force. A princess has a prince. The mythological world has Zeus. And the online sphere has the Bing network. Every story needs a hero, and the Bing network has seamlessly shifted into the role that appears to have been tailor-made for it.
Combining the latest search technology with sophisticated levels of personalization, Bing has played a lead role for many years. Recently, the brilliant minds behind the platform have brought search to an even higher level, and we couldn't be more thrilled.
Since we utilize the Bing network on a daily basis within our own company as well as our client's strategies, we are thrilled to have front-row seats for Bing's expanding network capabilities; now also reaching AOL, Apple, as well as Amazon.
With over 14 billion monthly searches around the world, Microsoft Bing ads excel at creating important connection points that translate into higher exposure as well as elevated conversion rates for commerce.
According to new data from comScore, Bing searches have been steadily growing and about 20% of all desktop searches utilize this technology. Pair that with the success of Windows 10 and the new Edge browser, and you get a surefire way to reach a massive new audience with tactical precision.
Bing ads contain a new kind of intelligence that allows knowledge to be communicated to the consumer in a more organic manner. The systems is able to predict needs and wants in real-time, as well as dynamically serve the ads that resonate best with the users' online actions and behavioral patterns.
By utilizing tools such as ActionLink, Review, and Form Extensions within the Bing ads, we also discovered we had more control when targeting specific products and services. We also had access to new tools in the Bing Shopping Campaigns which made it easy to manage and scale our clients quickly.
While the connection points and management tools are a huge part of why we love the Bing network, our favorite aspect is the platform itself, and the intelligence that drives the technology.
During a recent conversation with Ellen Vlagakos from Bing, we discussed how these new systems are creating touchpoints that have a very sophisticated way of reaching users globally, as well as more intelligently.
And at the end of our day, we were looking for more than a product that demonstrates search statistics or utilizes algorithms to predict behaviors. We were looking for a platform that utilizes statistic intelligence, analytical skills with an increased ROI, and connects people with the life moments that matter most. The fact that our clients are generating more revenue from running Bing Ads; well that's just the cherry on the cake of this amazing search marketing pie that we all truly love to be part of.
Bing in, click in, and get your products ads into the right platform. And in the case that you need any help to clear up any questions, click the below to go directly to our bing ads agency contact page to connect with a search consultant anytime.


Niners Gear .com has San Francisco 49ers lawn & garden products! If you're looking for quality Forty Niners outdoor items, you've come to the right place. If you can't find the SF 49ers merchandise you're looking for here, please try one of our partner sites.


If your beloved old Fido needs a little help getting around, but you can't afford an expensive dog wheelchair, don't give up on him just yet! You can create your own durable, reliable, and inexpensive dog wheelchair at home for under twenty dollars. Whether your dog is big, small, or still growing, you can use adjustable, durable PVC piping to create a helpful wheelchair that is just the right fit.
Determine what length of PVC you will need by measuring the height, width, and length of your dog. Keep in mind that your dog must be able to comfortably reach the ground with his usable legs in order to pull himself along. Also, account for the wheels you will attach to the pipe.
Cut four carefully measured pieces of PVC piping, according to the height of your dog. Additionally, cut two measured pieces of PVC, according to your dog's width.
Measure your fabric according to the width and length of your dog. You'll want to leave some slack so your dog can comfortably rest in the material, as though it was a sling. Fold the material over both sides of the PVC.
Sew the fabric, creating the hole for the PVC to go through and slide the piping through. Next join all of the PVC pieces together with the PVC glue. Use the elbows as the frame and the T sections for the pieces that go across, holding each side together.
Add the wheels to the bottom of your wheelchair.
Provide your pet with additional comfort and support. Cut pieces of memory foam with your box cutter, gluing them around the inside of the wheelchair.


We love kids and young people and we love healthy food. That´s why our job is not only a job - it´s our passion!
If you have any questions, wishes and suggestions you can always contact us and if you have a problem, we are sure to find a solution!


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The Paradise Papers blow open tax haven secrets of the ultra-rich
The publication of 13.4m leaked files provoke strong reaction, supply chain survey's sober Brexit findings, polymer note consultation row, living wage good news, new Queensferry Crossing speed limit
Philip Gates
First there was Wikileaks, then there was the Panama Papers - with a Westminster expenses scandal added in.
Now the Paradise Papers have lifted the lid on exactly how the ultra-rich and powerful secretly store their wealth offshore.
The leaks, like Wikileaks before, are making waves all over the globe.
In the US an inquiry has been called after files revealed the business links between Donald Trump's commerce secretary Wilbur Ross and a Russian firm co-owned by Vladimir Putin's son-in-law.
Meanwhile the Duchy of Lancaster, which provides the Queen with an income, held about £10m of Her Majesty's private money offshore.
Among its investments were funds in the Cayman Islands and Bermuda.
The Paradise Papers have shone a light on the financial affairs of the Queen, US Secretary of Commerce Wilbur Ross and Everton FC
The papers even focus on who owns English club Everton and whether Premier League rules have been broken.
Those opposed to such practices have been quick to point out how it looks like "one rule for the rich and another for everyone else" when it comes to tax.
But what exactly are the Paradise Papers and how deep does the leak go? Take a look at Insider's guide.
Supply chain Brexit survey findings emerge
It wouldn't be the start of another week if there wasn't a Brexit survey.
It fact almost day doesn't go by without a survey about the impact on businesses of leaving the EU.
It's understandable if you're suffering Brexit overload, especially as it's still very much a voyage into the unknown.
But the process of exiting the European Union is one fraught with danger for business if it doesn't go well.
This research is from the Chartered Institute of Procurement and Supply and involved EU businesses and their UK supply chains.
Here's what they found.
Bank of England polymer bank note consultation cost revealed
Do you remember the furore surrounding polymer bank notes and the use of tallow, or rendered animal fat, to make them?
It resulted in the Bank of England launch a consultation on the matter.
Now the cost of that consultation has been released following a Freedom of Information request by the Press Association.
It's caused a bit of a stink at the amount of money involved.
Living wage to go up
Does your business pay the living wage?
If so, then you've committed to putting it up.
However, if your company doesn't pay the living wage then your staff are among the 404,000 employees - nearly one in five of the Scottish workforce - not on it.
Here's what those who do get the living wage will now earn.
Queensferry Crossing speed limit rises
It's hard to believe but it's already more than two months since the Queensferry Crossing opened.
Its entrance into the world of transport was far from easy though as the closure of the Forth Bridge to traffic put it under immediate pressure.
Now things perhaps seem to be running more smoothly (although, dear readers, feel free to put me right).
As a result the initial speed limit of 40mph - in case of 'driver distraction' - has been put up to 50mph.
And eventually it will hit 70mph, like all dual carriageways.
But if its use is still so heavy, will commuters ever get to travel that fast on it anyway? Only time will tell.


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Dominion 1.01 "Pilot"
Remember that movie called Legion from 2010? It was written and directed by Scott Stewart and was basically about God losing faith in the human race and therefore sending his angels, led by Gabriel, to destroy humanity. But the Archangel Michael saw that there were good humans, sided with them, and managed to contain Gabriel's fury, in some pretty cool fights.
These were not your typical beautiful angels, but creepy beings – fallen angels – that were able to possess humans and have them walk over walls, have impossible strength or demonic appearance. Plus there was a pregnant woman who was going to give birth to humanity's savior.
Ok, so even though the movie didn't get great reviews, I remember enjoying it, so when I learnt that there was going to be a SyFy TV series, with a pilot written and directed by Stewart again, telling the story of what came after the events of Legion, I jumped in. And here we are.
Dominion starts strong; presenting us with a rebellious low-ranking soldier named Alex Lannen (Christopher Egan) – part of a half-futuristic, half-Middle Ages-style Corps – of a new nation state called Vega, where the city of Las Vegas used to be. This soldier hunts and kills two of Gabriel's angels, who, as in the movie, are occupying human bodies and have all kinds of creepy abilities, being declared enemies of the humans and all who stand with the Archangel Michael.
After this initial dose of action, a great deal of time is devoted to presenting the diverse characters and the style of life that the humans have. Through the dialogue between these characters we find out that the Archangel Gabriel – the bad guy – and his hordes have wiped out almost all of humanity, and Vega is a caste system, democracy forgotten, much like in the Middle Ages.
The city is run by the House of Riesen, and specifically by General Edward Riesen (played by Alan Dale), whose daughter, Claire Riesen (Roxanne McKee) is secretly in love with Alex and plans to tell her father the truth, believing he will approve of their marriage. However, Alex, knowing his place in the structure of things, believes the only way for them to be together is to escape Vega and start a life of their own.
To make matters worse, there's another ruling branch in Vega, the House of Whele, and its leader, David Whele (Anthony Head), intends to marry his son William (Luke Allen-Gale) to Claire, forming a coalition and gaining power over Vega. While Edward Riesen is portrayed as the tired ruler, reconsidering his way of doing things and even thinking his abdication and going back to democracy, Whele is the other side of the coin: craving power, he tries to instill fear in the hearts of the people of Vega – control by fear, much like many of today's most powerful countries do.
And then there is Michael (Tom Wisdom), overseeing things from the shadows, with a Matrix-esque look. He is, from his first appearance, a grim character with a mysterious look on his face, which makes it difficult to wonder if his intentions are good or evil.
However, maybe the best part of the episode is left for the last half hour – yeah, the pilot lasted 90 minutes! – where viewers not only get a dose of Michael vs. powerful angels (called the Powers) in the service of Gabriel (Carl Beukes) – as they fly their way from Gabriel's stronghold to Vega, endangering the city's nuclear power plant – but we also get very interesting character development for Alex Lannen and his missing father, Jeep (Langley Kirkwood), now back in the fold after being thought dead for years.
As it turns out, Jeep had been missing from his son's life because he was investigating the meaning of the strange markings all over his body, which not even Michael could understand. During this fruitless investigation, he found proof that Gabriel is readying an army of angels to start a war.
Through the whole episode, there had been talk of "the chosen one" who would save humanity. I had my guess as to who that would be, but it isn't almost until the end, because of a character's death, that it stands revealed. I liked how this was presented, and how this revelation might change the characters' lives going forward.
Overall, this was a good pilot; Well balanced, ambitious, and while maybe too many characters were introduced, by the end one had a good sense of what was going on, even if the last minute cliffhanger left us with some questions to solve.
The war is about to start. Let's hope the ride – or should I say flight? – is a strong one.
I'll be here, watching the skies.
Alan DaleAnthony HeadCarl BeukesChristopher EganDominionLangley KirkwoodLegionLuke Allen-GaleRoxanne McKeeSam Salama CohenScott StewartSyfyTom Wisdom
Muppets 101 – Julie Andrews: One Step into Spring (1978)
Lost in Translation 101: The Four Players
The Hills Have Eyes (1977) vs The Hills Have Eyes (2006) by Corin Totin
The Musketeers 2.06 "Through a Glass Darkly" by Thom V. Young


Twins Andres and Gael live and play on the remote island of Visayas.
The inseparable brothers play unhindered by the stark environment that has been ravaged by a strong typhoon.
When another boy from the village enters the picture, it puts their relationship to the test.
Gael finds himself neglected by Andres who forms a connection with his new friend.
It's a bond that raises judgement in the small village community.
Together, the brothers learn about the power of love — amongst friends, themselves, and each other.
'Hilom' was the most-watched, most-loved short film last month, and it's our December Viddsee Shortee!
Watch last month's shortee, 'Made In Bali', about a young man's quest to Bali to uncover past demons.


text:
David Cannon
Matrix Chess with Zillions-of-Games
This page is written by the game's inventor, David Cannon. This game is a favorite of its inventor.
Matrix Chess
I first discovered the unique tessallation of pentagons and diamonds sometime in 2003, and thought it would make a great board for a chess-like game. As I knew nothing about Zillions of Games programming at the time, I just jotted down a few basic ideas about piece movements (I thought of the WARLORD at that time), and put the project on the shelf. After learning a little Zillions programming, I returned to the idea in March 2010, incorporating some of my original ideas, along with some borrowed from other variants.
There are four ways to capture pieces: displacement (as in FIDE and many other variants), assimilation (absorbing the powers of captured pieces, as well as friendly pieces through "mergers"), conversion, and sandwiching. See the Rules section for details.
The pieces, except for Pawns, Guards, and the King, are grouped together in two "families". Please see the diagrams illustrating how they move.
There are four ways to make captures:
1. Displacement - enemy pieces that are not of the same "family" are simply removed from the board, as in FIDE and most other traditional varieties of Chess.
2. Assimilation - a piece may capture both friends and foes of the same "family" and assimilate their powers. The Rook (a sliding piece) may merge with a Ringmaster (also a slider) to form a Princess. It may not merge with, say, a Knight, because the Knight is not a slider.
Note that compound pieces formed this way may be split apart later. In the Zillions implementation, to break a Princess down into its components, simply click your mouse on the cell where you want the Rook-part or the Ringmaster-part to go. That part will move, leaving the other part behind. Fergus Duniho first popularized this method of capture in some of his games in the early 2000s.
3. Conversion - a leaping piece (Knight, Archer, Airman, Sailor, or any compound thereof) may convert an enemy piece to a friendly piece simply by flying over it and landing on the cell beyond. N.B. If the cell beyond is also occupied by an enemy piece, a leaper may make two captures simultaneously. For example, a Knight flying over an enemy Rook and landing on top of an enemy Spire would convert the former and kill the latter, in one move. An Archer flying over an enemy Ringmaster and landing on top of a Knight (either friend or foe) would simultaneously convert the Ringmaster and assimilate the Knight.
4. Sandwiching - Pawns and Guards also convert enemy pieces to friendly pieces, by "sandwiching." An enemy Knight caught between two friendly Pawns, for example, is converted to a friendly Knight. On rare occasions, Pawns and Guards may be able to capture two pieces simultaneously.
There are three ways to win:
1. Checkmate.
2. Stalemate - I would like to make this better than a draw, but not quite as good as a checkmate. In tournaments, FIDE awards one point for a checkmate and a half-point to each player for a draw, with stalemate counting as a draw. For this game (and any others that I invent), I would award a half-point for a stalemate - but only to the player forcing the stalemate. I cannot implement this in the Zillions programme, as it does not differentiate between superior and inferior wins, so for the Zillions programme, a stalemate is a win.
3. Converson of the King - given that leaping pieces convert enemy pieces by flying over them, and that Pawns and Guards also convert enemy pieces by sandwiching, it is possible for the King to be converted to an enemy piece (this actually happened once while playtesting this game with Zillions). The player whose King defects to the enemy, of course, loses the game.
Piece values
Zillions of Games estimates that the pieces have the following values on the larger of the two boards:
Guard - 6147 (0.7 pawns); Pawn - 8501; Crusader - 14423 (1.7 pawns); Knight - 20059 (2.4 pawns); Archer - 20062 (2.4 pawns); Monk - 25860 (3.0 pawns); Airman - 26783 (3.2 pawns); Bishop - 48562 (5.7 pawns); Warlord - 51135 (6.0 pawns); Rook - 83304 (9.8 pawns).
For reasons explained above, the published version of Zillions merges the Warlord and Monk into a single piece with a value of 69901 (8.2 pawns). The Knight and Crusader are also merged, with a value of 27932 (3.3 pawns). In practice, that results in a slight distortion: It overvalues the Warlord and Knight (representing the Monk and Crusader) on diamonds, while undervaluing them on pentagons. The fact that there is no way for one of these pieces to move from a diamond to a pentagon or vice versa makes it simpler for programming purposes to merge them, but causes some value distortion. I thought the compromise was worth it, however, as it affects both players equally, thereby avoiding giving any unfair advantage to either player.
The compound pieces are worth slightly more than the sum of their parts. I personally disagree with some of the Zillions estimates but assigning values to pieces is not an exact science; even experts disagree about the relative value of the pieces in FIDE chess, and the value assigned to the Queen by Zillions (7.7 pawns) is less than what most experts estimate.
Despite the inherent subjectivity of Zillions estimates, they are good as a rough guide.
Play Matrix Chess!
I have programmed a Zillions of Games file to play this game. You may download it here. You need the Zillions of Games engine installed to play it.
By David Cannon.
2dLargeShape14 x 14
Shape: Cells
Matrix Chess. Chess played on a tessellation of pentagons and diamonds. The name comes from the matrix in which diamonds are found. (14x14, Cells: 196)
David Cannon wrote on 2010-06-14 EDT
Thanks David! 1MB per day should definitely give me enough space to upload a game at a single sitting from now on. I really appreciate it.
Anyway, this game, along with the associated Zillions page, is now ready to go live:-)
David Howe wrote on 2010-06-14 EDT
Hi David, OK, I have increased the limit to 1Mb for file size and for the daily limit. Please let me know if you need more. Also let me know when you're ready for this page to be posted. Thanks!
Please bear with me, everyone. I've got several more images and diagrams, as well as two Zillions of Games files to upload, but I've exceeded my 500kb limit for today, so that will have to wait 24 hours.
Here may not be the place to discuss it, but I would like to propose raising the daily file size limit to 1MB. I think it would make work a lot easier for many of us.
https://www.chessvariants.com/invention/matrix-chess
First Created: Tuesday, June 15th, 2010
Last Modified: Tuesday, June 15th, 2010


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Browsing by Subject "AUTISM SPECTRUM DISORDER"
ASD-Associated De Novo Mutations in Five Actin Regulators Show Both Shared and Distinct Defects in Dendritic Spines and Inhibitory Synapses in Cultured Hippocampal Neurons
Hlushchenko, Iryna; Khanal, Pushpa; Abouelezz, Amr; Paavilainen, Ville O.; Hotulainen, Pirta (2018)
Many actin cytoskeleton-regulating proteins control dendritic spine morphology and density, which are cellular features often altered in autism spectrum disorder (ASD). Recent studies using animal models show that autism-related behavior can be rescued by either manipulating actin regulators or by reversing dendritic spine density or morphology. Based on these studies, the actin cytoskeleton is a potential target pathway for developing new ASD treatments. Thus, it is important to understand how different ASD-associated actin regulators contribute to the regulation of dendritic spines and how ASD-associated mutations modulate this regulation. For this study, we selected five genes encoding different actin-regulating proteins and induced ASD-associated de novo missense mutations in these proteins. We assessed the functionality of the wild-type and mutated proteins by analyzing their subcellular localization, and by analyzing the dendritic spine phenotypes induced by the expression of these proteins. As the imbalance between excitation and inhibition has been suggested to have a central role in ASD, we additionally evaluated the density, size and subcellular localization of inhibitory synapses. Common for all the proteins studied was the enrichment in dendritic spines. ASD-associated mutations induced changes in the localization of alpha-actinin-4, which localized less to dendritic spines, and for SWAP-70 and SrGAP3, which localized more to dendritic spines. Among the wild-type proteins studied, only alpha-actinin-4 expression caused a significant change in dendritic spine morphology by increasing the mushroom spine density and decreasing thin spine density. We hypothesized that mutations associated with ASD shift dendritic spine morphology from mushroom to thin spines. An M554V mutation in alpha-actinin-4 (ACTN4) resulted in the expected shift in dendritic spine morphology by increasing the density of thin spines. In addition, we observed a trend toward higher thin spine density withmutations inmyosin IXb and SWAP-70. Myosin IIb and myosin IXb expression increased the proportion of inhibitory synapses in spines. The expression of mutated myosin IIb (Y265C), SrGAP3 (E469K), and SWAP-70 (L544F) induced variable changes in inhibitory synapses.
Beyond Axon Guidance : Roles of Slit-Robo Signaling in Neocortical Formation
Gonda, Yuko; Namba, Takashi; Hanashima, Carina (2020)
The formation of the neocortex relies on intracellular and extracellular signaling molecules that are involved in the sequential steps of corticogenesis, ranging from the proliferation and differentiation of neural progenitor cells to the migration and dendrite formation of neocortical neurons. Abnormalities in these steps lead to disruption of the cortical structure and circuit, and underly various neurodevelopmental diseases, including dyslexia and autism spectrum disorder (ASD). In this review, we focus on the axon guidance signaling Slit-Robo, and address the multifaceted roles of Slit-Robo signaling in neocortical development. Recent studies have clarified the roles of Slit-Robo signaling not only in axon guidance but also in progenitor cell proliferation and migration, and the maturation of neocortical neurons. We further discuss the etiology of neurodevelopmental diseases, which are caused by defects in Slit-Robo signaling during neocortical formation.
Copy number elevation of 22q11.2 genes arrests the developmental maturation of working memory capacity and adult hippocampal neurogenesis
Boku, Shuken; Takeshi, Izumi; Abe, Seiji; Takahashi, Tomohisa; Nishi, Akira; Nomaru, Hiroko; Naka, Yasuhiko; Kang, Gina; Nagashima, Masako; Hishimoto, Akitoyo; Hishimoto, Akitoyo; Enomoto, Shingo; Duran Torres, Gilberto; Tanigaki, Kenji; Zhang, Jinghang; Ye, Kenny; Kato, Shigeki; Männistö, Pekka Topias; Kobayashi, Kazuto; Hiroi, Noboru (2018)
Working memory capacity, a critical component of executive function, expands developmentally from childhood through adulthood. Anomalies in this developmental process are seen in individuals with autism spectrum disorder (ASD), schizophrenia and intellectual disabilities (ID), implicating this atypical process in the trajectory of developmental neuropsychiatric disorders. However, the cellular and neuronal substrates underlying this process are not understood. Duplication and triplication of copy number variants of 22q11.2 are consistently and robustly associated with cognitive deficits of ASD and ID in humans, and overexpression of small 22q11.2 segments recapitulates dimensional aspects of developmental neuropsychiatric disorders in mice. We capitalized on these two lines of evidence to delve into the cellular substrates for this atypical development of working memory. Using a region- and cell-type-selective gene expression approach, we demonstrated that copy number elevations of catechol-O-methyl-transferase (COMT) or Tbx1, two genes encoded in the two small 22q11.2 segments, in adult neural stem/progenitor cells in the hippocampus prevents the developmental maturation of working memory capacity in mice. Moreover, copy number elevations of COMT or Tbx1 reduced the proliferation of adult neural stem/progenitor cells in a cell-autonomous manner in vitro and migration of their progenies in the hippocampus granular layer in vivo. Our data provide evidence for the novel hypothesis that copy number elevations of these 22q11.2 genes alter the developmental trajectory of working memory capacity via suboptimal adult neurogenesis in the hippocampus.
De novo variants in neurodevelopmental disorders with epilepsy
EuroEPINOMICS-RES Consortium; Heyne, Henrike O.; Linnankivi, Tarja; Palotie, Aarno; Daly, Mark J.; Lehesjoki, Anna-Elina (2018)
Epilepsy is a frequent feature of neurodevelopmental disorders (NDDs), but little is known about genetic differences between NDDs with and without epilepsy. We analyzed de novo variants (DNVs) in 6,753 parent-offspring trios ascertained to have different NDDs. In the subset of 1,942 individuals with NDDs with epilepsy, we identified 33 genes with a significant excess of DNVs, of which SNAP25 and GABRB2 had previously only limited evidence of disease association. Joint analysis of all individuals with NDDs also implicated CACNA1E as a novel disease-associated gene. Comparing NDDs with and without epilepsy, we found missense DNVs, DNVs in specific genes, age of recruitment, and severity of intellectual disability to be associated with epilepsy. We further demonstrate the extent to which our results affect current genetic testing as well as treatment, emphasizing the benefit of accurate genetic diagnosis in NDDs with epilepsy.
Evidence for spared attention to faces in 7-month-old infants after prenatal exposure to antiepileptic drugs
Videman, Mari; Stjerna, Susanna; Roivainen, Reina; Nybo, Taina; Vanhatalo, Sampsa; Gaily, Eija; Leppanen, Jukka M. (2016)
Introduction: Prenatal antiepileptic drug (AED) exposure is associated with an increased risk of cognitive impairment and autism spectrum disorders detected mainly at the age of two to six years. We examined whether the developitiental aberrations associated with prenatal AED exposure-could be-detected already in infancy and whether effects on visual attention can be observed at this early age. Material and methods: We compared a prospective cohort of infants with in utero exposure to AED (n = 56) with infants without drug exposures (n = 62). The assessments performed at the age of seven months included standardized neurodevelopmental scores (Griffiths Mental Developmental Scale and Hammersmith Infant Neurological Examination) as well as a novel eye-tracking-based test for visual attention and orienting to faces. Background information included prospective collection of AED exposure data, pregnancy outcome, neuropsychological evaluation of the mothers, and information on maternal epilepsy type. Results: Carbamazepine, oxcarbazepine, and valproate, but not lamotrigine or levetiracetam, were associated with impaired early language abilities at the age of seven months. The general speed of visuospatial orienting or attentional bias for faces measured by eye-tracker-based tests did not differ between AED-exposed and control infants. Discussion: Our findings support the idea that prenatal AED exposure may impair verbal abilities, and this effect may be detected already in infancy. In contrast, the early development of attention to faces was spared after in utero AED exposure. (C) 2016 Elsevier Inc. All rights reserved.
Gestational Exposure to Selective Serotonin Reuptake Inhibitors and Offspring Psychiatric Disorders : A National Register-Based Study
Malm, Heli; Brown, Alan S.; Gissler, Mika; Gyllenberg, David; Hinkka-Yli-Salomaki, Susanna; McKeague, Ian W.; Weissman, Myrna; Wickramaratne, Priya; Artama, Miia; Gingrich, Jay A.; Sourander, Andre (2016)
Objective: To investigate the impact of gestational exposure to selective serotonin reuptake inhibitors (SSRIs) on offspring neurodevelopment. Method: This is a cohort study using national register data in Finland between the years 1996 and 2010. Pregnant women and their offspring were categorized into 4 groups: SSRI exposed (n = 15,729); exposed to psychiatric disorder, no antidepressants (n = 9,651); exposed to SSRIs only before pregnancy (n = 7,980); and unexposed to antidepressants and psychiatric disorders (n = 31,394). We investigated the cumulative incidence of offspring diagnoses of depression, anxiety, autism spectrum disorder (ASD), and attention-deficit/hyperactivity disorder (ADHD) for the 4 groups from birth to 14 years, adjusting for confounders. Results: The cumulative incidence of depression among offspring exposed prenatally to SSRIs was 8.2% (95% CI = 3.1-13.3%) by age 14.9 years, compared with 1.9% (95% CI = 0.9-2.9%) in the psychiatric disorder, no medication group (adjusted hazard ratio [HR] = 1.78; 95% CI = 1.12-2.82; p=.02) and to 2.8% (95% CI = 1.4-4.3%) in the SSRI discontinued group (HR = 1.84; 95% CI = 1.14-2.97; p=.01). Rates of anxiety, ASD, and ADHD diagnoses were comparable to rates in offspring of mothers with a psychiatric disorder but no medication during pregnancy. Comparing SSRI exposed to unexposed individuals, the HRs were significantly elevated for each outcome. Conclusion: Prenatal SSRI exposure was associated with increased rates of depression diagnoses in early adolescence but not with ASD or ADHD. Until confirmed, these findings must be balanced against the substantial adverse consequences of untreated maternal depression.
Identification of novel candidate disease genes from de novo exonic copy number variants
Gambin, Tomasz; Yuan, Bo; Bi, Weimin; Liu, Pengfei; Rosenfeld, Jill A.; Coban-Akdemir, Zeynep; Pursley, Amber N.; Nagamani, Sandesh C. S.; Marom, Ronit; Golla, Sailaja; Dengle, Lauren; Petrie, Heather G.; Matalon, Reuben; Emrick, Lisa; Proud, Monica B.; Treadwell-Deering, Diane; Chao, Hsiao-Tuan; Koillinen, Hannele; Brown, Chester; Urraca, Nora; Mostafavi, Roya; Bernes, Saunder; Roeder, Elizabeth R.; Nugent, Kimberly M.; Bader, Patricia I.; Bellus, Gary; Cummings, Michael; Northrup, Hope; Ashfaq, Myla; Westman, Rachel; Wildin, Robert; Beck, Anita E.; Immken, LaDonna; Elton, Lindsay; Varghese, Shaun; Buchanan, Edward; Faivre, Laurence; Lefebvre, Mathilde; Schaaf, Christian P.; Walkiewicz, Magdalena; Yang, Yaping; Kang, Sung-Hae L.; Lalani, Seema R.; Bacino, Carlos A.; Beaudet, Arthur L.; Breman, Amy M.; Smith, Janice L.; Cheung, Sau Wai; Lupski, James R.; Patel, Ankita; Shaw, Chad A.; Stankiewicz, Pawel (2017)
Background: Exon-targeted microarrays can detect small ( Methods: We retrospectively analyzed data from 63,127 patients referred for clinical chromosomal microarray analysis (CMA) at Baylor Genetics laboratories, including 46,755 individuals tested using exon-targeted arrays, from 2007 to 2017. Small CNVs harboring a single gene or two to five non-disease-associated genes were identified; the genes involved were evaluated for a potential disease association. Results: In this clinical population, among rare CNVs involving any single gene reported in 7200 patients (11%), we identified 145 de novo autosomal CNVs (117 losses and 28 intragenic gains), 257 X-linked deletion CNVs in males, and 1049 inherited autosomal CNVs (878 losses and 171 intragenic gains); 111 known disease genes were potentially disrupted by de novo autosomal or X-linked (in males) single-gene CNVs. Ninety-one genes, either recently proposed as candidate disease genes or not yet associated with diseases, were disrupted by 147 singlegene CNVs, including 37 de novo deletions and ten de novo intragenic duplications on autosomes and 100 X-linked CNVs in males. Clinical features in individuals with de novo or X-linked CNVs encompassing at most five genes (224 bp to 1.6 Mb in size) were compared to those in individuals with larger-sized deletions (up to 5 Mb in size) in the internal CMA database or loss-of-function single nucleotide variants (SNVs) detected by clinical or research whole-exome sequencing (WES). This enabled the identification of recently published genes (BPTF, NONO, PSMD12, TANGO2, and TRIP12), novel candidate disease genes (ARGLU1 and STK3), and further confirmation of disease association for two recently proposed disease genes (MEIS2 and PTCHD1). Notably, exon-targeted CMA detected several pathogenic single-exon CNVs missed by clinical WES analyses. Conclusions: Together, these data document the efficacy of exon-targeted CMA for detection of genic and exonic CNVs, complementing and extending WES in clinical diagnostics, and the potential for discovery of novel disease genes by genome-wide assay.
Investigation of common, low-frequency and rare genome-wide variation in anorexia nervosa
Eating Disorder Working Grp Psych; Huckins, L. M.; Palotie, A.; Palta, P.; Kaprio, J.; Keski-Rahkonen, A.; Raevuori, A. H. (2018)
Anorexia nervosa (AN) is a complex neuropsychiatric disorder presenting with dangerously low body weight, and a deep and persistent fear of gaining weight. To date, only one genome-wide significant locus associated with AN has been identified. We performed an exome-chip based genome-wide association studies (GWAS) in 2158 cases from nine populations of European origin and 15 485 ancestrally matched controls. Unlike previous studies, this GWAS also probed association in low-frequency and rare variants. Sixteen independent variants were taken forward for in silico and de novo replication (11 common and 5 rare). No findings reached genome-wide significance. Two notable common variants were identified: rs10791286, an intronic variant in OPCML (P = 9.89 x 10(-6)), and rs7700147, an intergenic variant (P = 2.93 x 10(-5)). No low-frequency variant associations were identified at genome-wide significance, although the study was well-powered to detect low-frequency variants with large effect sizes, suggesting that there may be no AN loci in this genomic search space with large effect sizes.
Modified penetrance of coding variants by cis-regulatory variation contributes to disease risk
Castel, Stephane E.; Cervera, Alejandra; Mohammadi, Pejman; Aguet, Francois; Reverter, Ferran; Wolman, Aaron; Guigo, Roderic; Iossifov, Ivan; Vasileva, Ana; Lappalainen, Tuuli (2018)
Coding variants represent many of the strongest associations between genotype and phenotype; however, they exhibit interindividual differences in effect, termed 'variable penetrance'. Here, we study how cis-regulatory variation modifies the penetrance of coding variants. Using functional genomic and genetic data from the Genotype-Tissue Expression Project (GTEx), we observed that in the general population, purifying selection has depleted haplotype combinations predicted to increase pathogenic coding variant penetrance. Conversely, in cancer and autism patients, we observed an enrichment of penetrance increasing haplotype configurations for pathogenic variants in disease-implicated genes, providing evidence that regulatory haplotype configuration of coding variants affects disease risk. Finally, we experimentally validated this model by editing a Mendelian single-nucleotide polymorphism (SNP) using CRISPR/Cas9 on distinct expression haplotypes with the transcriptome as a phenotypic readout. Our results demonstrate that joint regulatory and coding variant effects are an important part of the genetic architecture of human traits and contribute to modified penetrance of disease-causing variants.
Psychological Status Associated With Low Quality of Life in School-Age Children With Neurodevelopmental Disorders During COVID-19 Stay-At-Home Period
Ueda, Riyo; Okada, Takashi; Kita, Yosuke; Ozawa, Yuri; Inoue, Hisami; Shioda, Mutsuki; Kono, Yoshimi; Kono, Chika; Nakamura, Yukiko; Amemiya, Kaoru; Ito, Ai; Sugiura, Nobuko; Matsuoka, Yuichiro; Kaiga, Chinami; Kubota, Masaya; Ozawa, Hiroshi (2021)
Background: This study seeks to ascertain how the COVID-19 stay-at-home period has affected the quality of life (QOL) of children with neurodevelopmental disorders (NDDs) who had experienced sleep schedules alteration and clarify what psychological status predicted low QOL in children with and without altered sleep patterns. Materials and Methods: Study participants were 86 children between 8 and 17 years of age (mean age, 11.7 years; 70 boys, 16 girls; mean intellectual quotient, 83.6). QOL was evaluated using the self-assessment KINDL(R). Participants answered questions regarding depression and anxiety on a visual analog scale (VAS) for temporary mood. Their parents answered questionnaires regarding their maladaptive behaviors and differences in sleep patterns before and during the COVID-19 pandemic. The student's t-test was performed to examine the presence or absence of sleep changes in the children, which affected QOL, temporary mood, and maladaptive behaviors. Multiple or simple linear regression analyses were also performed to identify the psychogenic factors that significantly affected decreased QOL for each group with and without changes in sleep schedule. Results: During the COVID-19 stay-at-home period, 46.5% of participants experienced changes in sleep patterns. These changes were associated with decreased QOL as well as internalized symptoms. The decreased QOL of children with sleep patterns changed was predicted by a high level of depression. In addition, low QOL in children with unchanged sleep patterns was predicted by a high level of depression and low current mood status. Conclusions: Almost half of the participants experienced a poor sleep schedule during the stay-at-home period. These alterations in sleep patterns were associated with a low QOL. The QOL of children with a stable life schedule was affected not only by depressive tendencies but also temporary moods. Therefore, they need to live a fulfilling life to maintain their QOL. However, the QOL of children with poor sleep patterns was affected only by depressive tendencies. Hence, clinicians need to ensure that children with NDDs are well-diagnosed with depression and treated for sleep problems.
The role of the microbiome in the neurobiology of social behaviour
Sarkar, Amar; Harty, Siobhan; Johnson, Katerina V-A; Moeller, Andrew H.; Carmody, Rachel N.; Lehto, Soili M.; Erdman, Susan E.; Dunbar, Robin I. M.; Burnet, Philip W. J. (2020)
Microbes colonise all multicellular life, and the gut microbiome has been shown to influence a range of host physiological and behavioural phenotypes. One of the most intriguing and least understood of these influences lies in the domain of the microbiome's interactions with host social behaviour, with new evidence revealing that the gut microbiome makes important contributions to animal sociality. However, little is known about the biological processes through which the microbiome might influence host social behaviour. Here, we synthesise evidence of the gut microbiome's interactions with various aspects of host sociality, including sociability, social cognition, social stress, and autism. We discuss evidence of microbial associations with the most likely physiological mediators of animal social interaction. These include the structure and function of regions of the 'social' brain (the amygdala, the prefrontal cortex, and the hippocampus) and the regulation of 'social' signalling molecules (glucocorticoids including corticosterone and cortisol, sex hormones including testosterone, oestrogens, and progestogens, neuropeptide hormones such as oxytocin and arginine vasopressin, and monoamine neurotransmitters such as serotonin and dopamine). We also discuss microbiome-associated host genetic and epigenetic processes relevant to social behaviour. We then review research on microbial interactions with olfaction in insects and mammals, which contribute to social signalling and communication. Following these discussions, we examine evidence of microbial associations with emotion and social behaviour in humans, focussing on psychobiotic studies, microbe-depression correlations, early human development, autism, and issues of statistical power, replication, and causality. We analyse how the putative physiological mediators of the microbiome-sociality connection may be investigated, and discuss issues relating to the interpretation of results. We also suggest that other candidate molecules should be studied, insofar as they exert effects on social behaviour and are known to interact with the microbiome. Finally, we consider different models of the sequence of microbial effects on host physiological development, and how these may contribute to host social behaviour.


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November 9, 2020 24hiphopmuzic Entertainment News 0
A lot of buisnesses and industries in Nigeria have been hit during the Coronavirus pandemic. One of those industries being Nigeria's fashion Industry.
Many events were meant to take place during this period but have been moved up. Woven Threads was such and was meant to actually take place in the physical world with many interactice sessions, workshops, and pop-up stores. If you know the fashion Industry, you should know that this event is a big deal, signifing the beginning of Nigeria's two fashion seasons.
Of course due to Covid-19, everything was now set to happen in the online world with a lot of Zoom calls with connection issues. One of such calls included Omoyemi Akerele, the founder of Lagos Fashion Week, Nike Ogunlesi, founder and CRO of Ruff n Tumble, Jumoke Oduwole, special adviser to the Nigerian president on Ease of Doing Business, and a few other fashion gurues. The 2 hour live session was about how African fashion can adapt to a fast-changing world of ruptured supply chains and cheap foreign textiles.
The bi-annual fashion event was a big deal and it brought a lot of models, fashion writers, insiders, and editors together. The event is has been host to many significant names in the fashion industry such as , Edward Enninful, the editor-in-chief of the british vogue as well as Naomi Campbell, Vogue's contributing editor and supermodel.
The sudden outbreak of Covid-19 in Italy was right at the time the Milan Fashion Week was taking place. It caused the many attendees to book early flights back to the countries. In Nigeria the Lagos Fashion Week Autumn/Winter shows moved to a more digital format and Arise Fashion Week to reschedule from April to October.
Designers income has been another victim of this outbreak. It wasn't much before and now that there is nothing, there can only be prayers for them.
Because of this outbreat, the fashion indutries supply chain has been cut off. Usually they sourse their raw materials from countries such as India, China, and places in Europe but are now forced to find and ultirior source locally.
Head of communications for Lagos Fashion Week, Onyinye Fafi-Obi says, "Sourcing locally has always been the more sustainable way to go. It will usher in more creative ways to sell to the consumer such as virtual consultations as opposed to being heavily reliant on in-person consultations." She continues, "more brands are also pivoting towards focusing on the Direct-To-Customer approach and gathering data on their consumers rather than relying on wholesale middlemen."
Most might see this out-break as a set back but it call also be seen as an oportinity for the fashion industry to grow on it's own. The industry which depended largely on western influece has now been forced to look locally for their spot light.
Onyinye says,"The African Fashion industry will forge its path as opposed to its reliance on western fashion structures. Looking inwards, we will continue to develop structures and platforms that work within the confinement and complexity of operating a fashion business in the continent. The pandemic has revealed that no one has all the answers and surviving will be dependent on every brand doing what works for them to stay afloat and alive. This notion will be carried into the Post-Covid19 world. More African fashion brands will be more in-tune with what works for their business and what doesn't. This will enable them to make more confident decisions concerning their value chain."
Passport of Prominent #EndSARS Activist "Modupe Odele" Seized By Govt


Red blooms like small single roses appear before the foliage emerges in the spring. A pretty ornamental when in bloom and an attractive shrub when the blooms disappear as well. Excellent for use as a spiny hedge. Hardy to -30F (-34.4C); height: 5ft.


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Indie game award finalists include 'Hyper Light Drifter' and 'Inside'
The Game Developers Choice awards also have their frontrunners.
Now that media outlets have handed out awards to blockbuster games, it's time for the indies to shine. The Independent Games Festival has posted the finalists for its main competition's 2017 awards, and there are a few competitors who clearly stand out from the pack. Both the retro hack-and-slasher Hyper Light Drifter and bleak side-scroller Inside are nominated not only for the Seumas McNally grand prize, but also the audio and visual design awards. Other titles receiving multiple nods will definitely sound familiar if you've been following the scene, including the hacking-themed puzzler Quadrilateral Cowboy and the chaotic food hit Overcooked.
The list shares a lot in common with what we've seen from indie categories in other awards programs, although it's definitely not a carbon copy. You just have to look at the Game Developers Choice awards nominees, which were unveiled a few days ago by the same parent organization. They have a few picks in common, such as Hyper Light Drifter and Stardew Valley. However, you won't find Campo Santo's well-received Firewatch anywhere on the IGF list while it's virtually ubiquitous on the GDC shortlists.
This isn't to knock either organization, though, and the GDC's mix of big-name and indie finalists has a few intriguing choices. You'll see obvious picks like Dishonored 2, Overwatch and Uncharted 4, but some of the games haven't had much recognition elsewhere, such as Oxenfree (best debut and narrative) and Jonathan Blow's The Witness (best design and the innovation award).
You'll have to wait until the Game Developers Conference on March 1st to see who the winners are for both GDC and IGF. Whoever wins, it's evident that many 2016 indie games earned at least a brief moment in the sun.
Source: Independent Games Festival, PR Newswire
In this article: av, firewatch, gamedeveloperschoice, games, gaming, gdc, hyperlightdrifter, igf, independentgamesfestival, indie, inside, overcooked, oxenfree, personal computing, personalcomputing, QuadrilateralCowboy, stardewvalley, thewitness


Digital marketing is not unlike the wild west. It can be a lawless place where bandits roam free, taking advantage of well meaning internet users. That's why search engines put algorithms in place to penalize anyone who engages in subversive techniques.
In the current digital landscape the terms "black hat" and "white hat" have come to describe two approaches to SEO. Black Hat SEO refers to sneaky or unscrupulous methods used to trick search engines for better rankings. While White Hat SEO is on the side of truth, morals and justice, following the letter of the law when it comes to gaining organic traffic.
This tactic is dying out for obvious reasons, but still a frequently seen spam strategy, with the main objective to get users to click on a link.
Whether or not she actually needs to use the app, or lose weight at all, is a matter of one's opinion, but in the digital word – this would be called a clickbait.
Adding irrelevant keywords in vague titles is a total taboo when it comes to user experience and SEO.
The exact same thing applies to social media. Websites and blogs gain traction from their titles, using them to promote certain content, products or services. If the linked title leads the user to irrelevant content, they lose interest almost immediately.
But, with black hat SEO, relevant content doesn't matter. Click baiting is meant to gain traction for a website and push it higher in search engine results through dishonest means. Black Hat SEO builds shallow domain authority using popular keywords with no substance.
Have you ever encountered a page that's just a pile of random links, sometimes with no context at all?
Upon encountering such a page, any normal human would wonder, "What kind of an insane person would build something like this?". But, if you're even remotely familiar with Search Engine Optimization, you know this is a tactic as old as SEO itself.
When Google crawlers scrape a web page and finds links, they assume the links are relevant to the source material. Google then categorize these pages and websites through their shared connection. The more connections Google finds to a certain website, the better it will show it in results pages.
Of course, in a perfect world, this would work for the benefit of quality search results. But, in the real world, many Black Hat villains have discovered how to build link farms, in order to dominate the most expensive search terms.
Soon enough, Google found out about this practice, and now their algorithm is updated to recognize this type of behavior. Though some sneak through and we are still seeing this practice in place.
We all love seeing a new comment on our freshly published blog post. It's always great to see someone interacting and giving feedback on the topics you actually care about.
Google does not track links in comments. It used to, but due to item #2 in this list, Google had to sanction this practice. Still, many Black Hats are utilizing this tactic, simply because they are relying on you, and anyone else reading the blog, to click on that link.
It's not unwarranted for your readers to promote their websites in the comments, but if they want to engage in any valid conversation, the links in the comments need to be relevant to the topic.
If they post a link to their blog on the same topic, they probably aren't trying to lure people under false pretenses. But, for example: if they post a link to an article about Kim Kardashian's weight on a post about knitting, you can assume it's spam and definitely a Black Hat tactic.
Feel free to delete that comment and forget that fake persona. Let the good old sherif Google take care of them.