Do you like travelling? I love it!!!!!!!
I have to say that travelling help me alot. I have learned alot from travelling everywhere. I'd like to be a gust of wind. Blowing everywhere.
I don't mind how life is happening to me!!! I mind how life is happening to everybody. That's why I love travelling.
I love it also, but my money doesn't help me :?
You know, some men travel without money.
iwantmore wrote: You know, some men travel without money.
travelling in his own town?
are you such a man?
Admiral wrote: are you such a man?
Oriani wrote: I love it also, but my money doesn't help me :?
I love it too :D !
Lucky you!! I travel every year and I really like it..but maybe (I'm not very sure) I'd like to have a job to travel a lot.. My mum says that like this I'll never have affections and real friends.. However..now I just wanna be a magistrate..so no problem!
yes, you're right.. so do i. I think it's dangerous to travel to England, USA, Vietnam. But I do it the same!
martazzz wrote: yes, you're right.. so do i. I think it's dangerous to travel to England, USA, Vietnam. But I do it the same!
No! I said Vietnam because ..because ..because.. I dont remember!
. Don't worry anymore, friend. I hope that you can visit my country once more time and you'll see how safe it is now. . We would be very please to welcome you, our foreign friends, to our country.
I WANT TO SPEND MY LIFE IN IT !!!
Re: Do you like travelling? I love it!!!!!!!
Well it depends on luck as well as some people have business tours to many countries on office expense. So dont complain Guys pray for your luck.
I love traveling. I love knowing people and smell air of new countries.
The smell is what I remember best when I close my eyes and I think to a land I have visited.
Landscapes and food are also great.
Well money is always an issue when it comes to travelling but when we are still young we can do it on a small budget !!
Low cost airlines....hostels.... fast food.... it is possible !
I love travelling because, I have come to know the tradition living styles and a lot more about the people where i travels.The main problem which i face in travelling is the lack of money. I wish i could have a lot of money and i can travel around the world.
I think, You like cowboys style.
Jokes a part... cowboys are not in Mexico!!!!
iwantmore wrote: I have to say that travelling help me alot. I have learned alot from travelling everywhere. I'd like to be a gust of wind. Blowing everywhere.
Hi, Nice hobby. I like to travel too, but I have same problem like you. My pocket doesn't allow me to do so.
You should say - Unfortunately, I don't have enough money to travel. We all have money, but we may not have enough money to do something.
The hope one day to be possible to arrive at other national traveling !!
But I don't have money,I can't complete this dream.
My money doesn't help me.
Welcome come to Taiwan !
yutinghsu wrote: I love it also.
Hahaha, I wrote THAT POST but 6 years ago when I was learning academic English.
Advice: Do not copy and paste; some posts may have grammar mistakes!
This is such a great point that you made in your post. Most of us could afford to travel but we spend money on things that seem important at the time but later we find out it wasn't that important. debt holds so many from traveling and seeing the world. so sad.
I really like to going for a traveling. My most favorite hobby is traveling. Traveling is down your stress and refresh your mind very well. Traveling is really good to know about different culture and different languages.
Hello, my name is Carla I love travel I usually go on holidays to Formentera, Ibiza, Albacete (Yeste), Madrid and Toledo. In Formentera I always visit lots of seas and beaches with very beautiful and crystalline water, where you can see lot of big fish. I Love Formentera, you have to go there!
In Ibiza I also go to a very famous cave called Can Marça where you can see stalagmites and stalactites of many years ago.
I often stay 15 days in Albacete to see my cousins. I enjoy the nature experience and the awesome landscape that is in there. One characteristic of Albacete is that I don't like the pisto manchego, I prefer the delicious fried cheese! Madrid is a very cool place too and I am crazy about it! I recommend you to go. Specifically to see the Lion king concert.
I often stay 15 days in Albacete to see my cousins. I enjoy the nature experience and the awesome landscape that is in there. One characteristic of Albacete is that I don't like the pisto manchego, I prefer the delicious fried cheese! Madrid is a very cool place too and I am crazy about it! I recommend you to go. Specifically to see the Lion king concert .
Traveling really broadens your view. Meeting new people and seeing new places are two things I love traveling for. I've been traveling mostly around Europe and can say that my favorite city so far is Stockholm.
It is beautiful, clean, and has that special atmosphere that makes you feel like home..
Don't worry be Happy https://goo.gl/hHougi ..


text:
The Ciprianis Just Added a Hotel to Their Empire in NYC
Mr. C Seaport has opened in Manhattan's rising Seaport District.
By Wendy O'Dea	 on September 8, 2018
Photo: Courtesy Mr. C Seaport
Manhattan's South Street Seaport has a mission: to become New York City's coolest new neighborhood. The historic district at the bottom tipof the island—lined with cobblestone streets and located at the apex of Lower Manhattan and the East River—has lately procured reason after reason for tourists (and, yes, even a few locals) to venture south, from new fashion boutiques (like the just-opened 10 Corso Como) to premier waterfront venues. Now, the developing district is ready for overnight guests thanks to the August opening of Mr. C Seaport.
Mr. C Seaport is the careful work of the fourth-generation Cipriani brothers, Maggio and Ignazio, whose family owns and operates the Cipriani restaurant empire, as well as another Mr. C hotel in Beverly Hills. The Bellini was, of course, created by the brothers' great-great-father, the legendary Giuseppe Cipriani, at Harry's Bar in Venice, Italy. Both the new Manhattan hotel and that long-beloved beverage of peach of Processo are equally sweet. Putting a modern and polished twist on classic European style, the Mr C was designed by Danish architect Thomas Juul-Hansen, who incorporated nautical touches and sleek, Italian glamour into the 66 rooms and grand public spaces.
The rooms, along with six suites, come with Casa Rovea Italian linens, sleek handmade Italian furniture (made exclusively for the property by Tedeschi), and BTL SVC bottled cocktails in the minibars. Mr. C's technology game is strong, too. Not only are rooms fitted with 50-inch interactive 4K televisions, but guests can communicate with hotel staff via tablets for room service and housekeeping requests or to activate their "do not disturb" status. Another cool feature is its TrayTracker technology that alerts housekeeping when room service trays have been moved into the hall.
While the Cipriani family operates a number of upscale restaurants throughout New York, the hotel's intimate restaurant, Bellini, introduces a new dining concept that will eventually be rolled out to other Mr. C properties. The menu is a blend of classic and modern Italian dishes, from fresh fish and seafood to homemade pastas and an impressive wine list. But the best place for a drink is on the private terraces of Mr C's top suites—the sixth-floor signature suite and the seventh-floor C suite—both of which feature views over Manhattan, the East River, Brooklyn, and Governor's Island.
Want to Fulfill Your New Year's Resolution? This New Hotel Suite Experience Wants to Help You
This $25,000 Hotel Package Will Let You Ring in the New Year on a 23rd-Floor Skating Rink
A Beloved Landmark Hotel in Palm Beach Gets a Makeover
Latest Galleries in Hotels
11 End-of-Decade-Worthy New Year's Eve Experiences Around the World

redpajama_set_name: RedPajamaCommonCrawl


Please don't bring phones, shoes, gym bags, hand towels, blocks, straps, etc. into the yoga room. We provide space for safe storage of these in the locker room.
Bring ONLY your mat, towel and water into the yoga room — this is all you need for a great class!
Avoid talking during class or in the yoga room after class ends. Respect the silence of your neighbors. You may talk quietly in the Yoga room before class.
Classes are 90, 75 or 60 minutes and we try very hard to start right on time. If you are running a bit late, you may still come in! We do not lock the door until about 10 minutes after starting class; just come in as quietly as possible.
If you must, on rare occasion, leave early, be sure to tell the teacher before class. When someone leaves the room, we like to know why so that we can make sure they are feeling ok.


text:
Home > Industry News > Metro-North told to improve signalling system after fatal derailment
Metro-North told to improve signalling system after fatal derailment
MTA has been ordered by the US Government to take action to ensure Metro-North services don't break speed limits in the future following a derailment that led to the deaths of four passengers.
The US Department of Transportation's Federal Railroad Administration (FRA) has issued an Emergency Order (EO) requiring Metro-North to upgrade its signalling or Automatic Train Control (ATC) systems.
The EO follows NTSB's analysis of the train's black box which discovered that the train had been travelling at 82 mph as it went into the 30 mph curve.
Four of the train's 120 passengers were killed in the accident on December 1 in which all seven cars derailed before Spuyten Duyvil station beside the Hudson River.
MTA must now take measures to modify its systems and in the meantime employ two qualified engineers on routes where 'major speed restrictions' are in place.
"Safety is our highest priority, and we must do everything we can to learn from this tragic crash and help prevent future derailments," said US Transportation Secretary Anthony Foxx.
If MTA fails to act, the FRA could take enforcement action against either the operator or individual employees who violate the order.
The FRA said it had already "increased its oversight and enforcement" of Metro-North lines following a collision between two trains in Connecticut in May.
A further investigation will now be conducted to assess MTA Metro-North's safety compliance with federal safety regulations.


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Study the Impact of the Drift (Lateral Deflection) of the Tall Buildings Due to Seismic Load in Concrete Frame Structures With Different Type of RC Shear Walls
Mahdi Hosseini, Prof.N.V.Ramana Rao
Story Drift is defined as the difference in lateral deflection between two adjacent stories. Lateral deflection and drift have three effects on a structure; the movement can affect the structural elements (such as beams and columns); the movements can affect non-structural elements (such as the windows and cladding); and the movements can affect adjacent structures. Without proper consideration during the design process, large deflections and drifts can have adverse effects on structural elements, nonstructural elements, and adjacent structures. Drift problem as the horizontal displacement of all tall buildings is one of the most serious issues in tall building design, relating to the dynamic characteristics of the building during earthquakes and strong winds. Drift shall be caused by the accumulated deformations of each member, such as a beam, column and shear wall. lateral forces due to wind or seismic loading must be considered for tall building design along with gravity forces vertical loads. Tall and slender buildings are strongly wind sensitive and wind forces are applied to the exposed surfaces of the building, whereas seismic forces are inertial (body forces), which result from the distortion of the ground and the inertial resistance of the building. These forces cause horizontal deflection is the predicted movement of a structure under lateral loads and The structural prototype is prepared and lots of data is been collected from the prototype. All the aspects such as safety of structure in shear, moment and in story drift have been collected. Main problems that would be arising due to earthquake in the structure are story drift and deflection of the building due to its large height and also torsion and others, so if the structure is proved to be safe in all the above mentioned problems than the structure would be safe in all cases in respect earthquak e. Shear Wall is A Structural Element Used to Resist Lateral, Horizontal, Shear Forces Parallel to the Plan
HOSSEINI, PROF.N.V.RAMANA RAO, Mahdi. Study the Impact of the Drift (Lateral Deflection) of the Tall Buildings Due to Seismic Load in Concrete Frame Structures With Different Type of RC Shear Walls. Global Journal of Research In Engineering, [S.l.], july 2018. ISSN 2249-4596. Available at: <https://engineeringresearch.org/index.php/GJRE/article/view/1787>. Date accessed: 18 jan. 2022.


Among its many findings, the report identifies a sizable gap between companies who consider/desire a sustainability strategy and those which actually have a sustainability strategy. It is not clear how a 'sustainability strategy' is defined, but let's assume we're not talking about "green washing" here where a business can reduce costs through low hanging fruit in its supply chain and market this as being environmentally responsible. Let's assume 'Sustainability' means authentic resource stewardship & management, akin to where the mission of a company is explicit about existing for a greater purpose than simply making products and profits. Even if we were to define 'sustainability' as a shade somewhere in the middle, the trigger still applies because no company can make sufficient progress or get all the way to bright without it.
Under traditional corporate law, traditional corporations must be managed only to produce value for stockholders. That's stockholders, not stakeholders. Corporate commitment to other interests in order to create sustainable long term value for shareholders is precluded. Profit maximization is the ultimate obligation of corporate directors.
"The object of the corporation is to produce profits for the stockholders and . . . the social beliefs of the managers, no more than their own financial interests, cannot be their end in managing the corporation." - Chief Justice of the DE Supreme Court Leo Strine, Wake Forest L. Rev. (2012).
The fundamental change required for corporations to break through on sustainability initiatives is to convert corporate structure to a Benefit Corporation and certified B-Corp by B-Lab. This provides the legal protection for directors to focus on sustainability initiatives along with profits, not only profits.
There are more than 1,700 B-Corps today across 130 industries. This is a drop in a bucket, but a start. Some of the more recognized names are Patagonia, Method/Ecover, and Warby Parker. Etsy became a B-Corp in May 2012 and then went public in April 2015, so it can be done. There are even 21 equity investment companies certified as a B-Corp. Let's celebrate and support these companies, and encourage more to do the same. Learn more about the process and requirements to become a B-Corp at bcorporation.net.
I absolutely applaud intent and progress of any kind, but the needle doesn't move unless the legal and financial model permits implementation. That permission is being a Benefit Corporation.


At the end of this year, Jason Jones will be stepping down as Elder for NCC after 6+ years of faithful service. Jason, his wife Allison, and their 2 children Ethan and Abigail, have been a huge part of our church life. Jason served the church in the areas of leadership, heading the finance team, leading Groups, and many other practical roles. He was also instrumental in serving on the board during a difficult transition time. Jason was part of hiring a new lead pastor, and helping to frame the new vision of NCC.
We are all very grateful for Jason's service and look forward to seeing how God uses him and his family in the future.


text:
Research ArticlePEDIATRICS
Whole-Brain Voxel-Based Morphometry in Kallmann Syndrome Associated with Mirror Movements
M. Koenigkam-Santos, A.C. Santos, T. Borduqui, B.R. Versiani, J.E.C. Hallak, J.A.S. Crippa and M. Castro
American Journal of Neuroradiology October 2008, 29 (9) 1799-1804; DOI: https://doi.org/10.3174/ajnr.A1202
M. Koenigkam-Santos
A.C. Santos
T. Borduqui
B.R. Versiani
J.E.C. Hallak
J.A.S. Crippa
M. Castro
BACKGROUND AND PURPOSE: There are 2 main hypotheses concerning the cause of mirror movements (MM) in Kallmann syndrome (KS): abnormal development of the primary motor system, involving the ipsilateral corticospinal tract; and lack of contralateral motor cortex inhibitory mechanisms, mainly through the corpus callosum. The purpose of our study was to determine white and gray matter volume changes in a KS population by using optimized voxel-based morphometry (VBM) and to investigate the relationship between the abnormalities and the presence of MM, addressing the 2 mentioned hypotheses.
MATERIALS AND METHODS: T1-weighted volumetric images from 21 patients with KS and 16 matched control subjects were analyzed with optimized VBM. Images were segmented and spatially normalized, and these deformation parameters were then applied to the original images before the second segmentation. Patients were divided into groups with and without MM, and a t test statistic was then applied on a voxel-by-voxel basis between the groups and controls to evaluate significant differences.
RESULTS: When considering our hypothesis a priori, we found that 2 areas of increased gray matter volume, in the left primary motor and sensorimotor cortex, were demonstrated only in patients with MM, when compared with healthy controls. Regarding white matter alterations, no areas of altered volume involving the corpus callosum or the projection of the corticospinal tract were demonstrated.
CONCLUSION: The VBM study did not show significant white matter changes in patients with KS but showed gray matter alterations in keeping with a hypertrophic response to a deficient pyramidal decussation in patients with MM. In addition, gray matter alterations were observed in patients without MM, which can represent more complex mechanisms determining the presence or absence of this symptom.
Kallmann syndrome (KS), first described by the pathologist Maestre de San Juan, is defined by the association of hypogonadotropic hypogonadism with complete (anosmia) or incomplete (hyposmia) olfaction disturbance. Prevalence has been estimated to be from 1:8,000 to 1:10,000 men.1 It is caused by a neuronal migration arrest that involves both the gonadotropin-releasing hormone (GnRH) and the olfactory neurons, which have a common embryonic origin.2,3 The first gene described, KAL1, encodes a protein named "anosmin," which shows a strong homology to axonal adhesion molecules involved in neuronal migration and axonal pathfinding.4 Recently, other gene mutations have been described in association with the disease.5,6
Various phenotypic abnormalities have been described in KS, including unilateral renal agenesis and specific neurologic disorders, such as bimanual synkinesia or mirror movements (MM).7 Currently, these characteristics are considered typical, but not exclusive, in the X-linked KS form of inheritance.8,9 MM consists of the involuntary movement of a body segment in reply to voluntary movement of the similar contralateral segment, more often seen in the hands. It can be observed in children and adolescents, decreasing gradually with age,10 but its presence in adults, if significant and sustained, is considered pathologic.11 On the basis of neuroimaging and electrophysiologic studies, 2 main hypotheses were elaborated concerning the cause of MM: abnormal development of the primary motor system, involving the ipsilateral corticospinal tract; and lack of contralateral motor cortex inhibitory mechanisms, mainly through the corpus callosum.12-14
Voxel-based morphometry (VBM) is a relatively recent method for morphometric evaluation, based on statistical analysis of pooled data,15,16 which showed pathologic changes of gray matter in various neurologic and psychiatric conditions, including Alzheimer disease, schizophrenia, and medial temporal lobe epilepsy.17-21 A previous study used conventional VBM to compare only the white matter attenuation of the brains of patients with the X-linked form of KS (exhibiting MM) and those of patients with autosomal inherited KS (no MM) and suggested a bilateral corticospinal tract hypertrophy involved in the MM etiology.22 Therefore, the purpose of our study was to use optimized VBM to determine white and gray matter volume changes in a KS population with a well-established genotypic and phenotypic status and to investigate the relationship between the abnormalities and the presence of MM, addressing the 2 mentioned hypotheses.
Subjects and Clinical Evaluation
This study was approved by our Institutional Review Board for Human Research and informed consent was obtained from all subjects.
Twenty-one patients with KS, recruited from the endocrinology clinics, were evaluated. All patients were male, with a mean age of 38 ± 12.6 years, ranging from 11 to 60 years of age. Criteria for the diagnosis of KS included clinical signs and symptoms of hypogonadism and clinical reports of hyposmia or anosmia. Complete laboratory endocrine status was obtained. Olfactory acuity was evaluated by the Smell Identification Test,23 indicating normal olfactory function, mild hyposmia, moderate hyposmia, severe hyposmia, or anosmia, based on the manufacturer's score.
MM was evaluated clinically, with a test adapted from Mayston et al.11 In brief, the patients sequentially opposed the tip of each finger to the tip of the thumb from index to little finger and back again and held the hands horizontal with fingers extended over the edge of a box and flexed each finger in turn several times. When involuntary movement of the homologous finger of the other hand was noted, MM was assessed as positive.
Genomic deoxyribonucleic acid was extracted from peripheral blood; the KAL1, FGFR1, and PROKR2 genes were amplified by polymerase chain reaction and then analyzed by a direct sequencing method.9 The urinary tract structure was assessed by abdominal ultrasound.
For the MR imaging and VBM evaluations, the patients were matched to 16 control healthy volunteers (all men; mean age, 34 ± 10.4 years; range, 22–50 years).
Image Acquisition
MR images were obtained on a 1.5T Magnetom Vision scanner (Siemens, Erlangen, Germany). Volumetric 3D magnetization-prepared rapid acquisition of gradient echo sequences of all 21 patients and the control group were acquired by using the same parameters: T1-weighted sagittal acquisition; TR = 9.7 ms; TE = 4.0 ms; flip angle = 12°; FOV = 255 mm; matrix = 512 × 224; section resolution equal to 1.0 × 1.0 × 1.0 mm, producing an isometric voxel of 1 mm3. For rhinencephalon evaluation, thin-section (3 mm) coronal turbo spin-echo T2-weighed images were acquired. Olfactory bulbs and sulci of the 21 patients and 16 healthy participants were evaluated by at least 2 radiologists (M.K-S. and A.C.S.).
VBM Protocol
The optimized VBM protocol of Good et al20 was applied to preprocess gray and white matter images, by using the statistical parametric mapping software (SPM2; Wellcome Department of Imaging Neuroscience, Institute of Neurology, London, UK) in Matlab Version 7.0 (MathWorks, Natick, Mass). In brief, a study-specific template and a priori probability maps for gray and white matter were created by averaging and smoothing all the images of the subjects. Using these study-specific templates, we spatially normalized and segmented all of the images, and then we applied these deformation parameters to the original images, which were segmented again. The resulting images were modulated by the Jacobian determinants from spatial normalization to correct for volume changes introduced during the nonlinear spatial transformations and smoothed (12-mm full width at half maximum isotropic Gaussian kernel). A measure of the total amount of gray matter was entered as a confound in an analysis of covariance. This covariate was given by the total number of voxels within the gray matter compartment of each subject. A t test statistic was then applied on a voxel-by-voxel basis between the groups to evaluate significant differences.
Data Analyses
Statistical analysis was performed within the SPM2 software package. Between-group statistical comparisons of mean gray and white matter volumes were performed with the general linear model, based on random Gaussian field theory. Resulting clusters in a priori regions were reported as significant only if including voxels with Z-values of >3.09, corresponding to the 2-tailed P < .001 level, uncorrected for multiple comparisons and an extent threshold of 25 voxels. Uncorrected P < .001 levels have been used in previous SPM analyses of functional24 and structural imaging data25 and are considered to provide protection against false-positive results when there are clear hypotheses as to the location of findings. Unpredicted findings were considered as significant only if they survived the False Discovery Rate correction for multiple comparison (P < .05).
On the basis of previous MM investigations, our hypothesis a priori–related cortical regions included the primary motor cortex (Brodmann area 4), primary somatosensory cortex (areas 1–3), supplementary motor cortex (area 6), and somatosensory association cortex (Brodmann areas 5 and 7), whereas white matter a priori areas were considered involving the corpus callosum or the corticospinal tract projection in the internal capsule, midbrain, pons, or medulla oblongata. For other gray and white matter regions, no a priori hypothesis could be established. The coordinates obtained for the peak voxels (ie, the anatomic location with maximal white and gray matter differences within each significant cluster) were transferred into Talairach space by using the Matthew Brett mni2tal routine (http://imaging.mrc-cbu.cam.ac.uk/imaging/MniTalairach). The anatomic locations of the peak voxels were found by using the Talairach Daemon Client.
The groups were the following: all patients with KS, with and without MM (group I) versus controls, patients with KS and MM (group II) versus controls, patients with KS without MM (group III) versus controls, and group II versus group III.
Region-of-Interest Analysis
To validate our VBM study, we carried out an independent region-of-interest (region of interest) analysis of the corpus callosum surface in the midline, performed on the original volumetric MR images. Using a semiautomatic region-of-interest plug-in tool in ImageJ 1.38 (Limewire tool plug-in, freeware; National Institutes of Health, Bethesda, Md; http://rsb.info.nih.gov/ij), we measured the midsagittal area of the corpus callosum in each individual at least twice. This analysis was blind, without knowing to which group any individual belonged. An independent t test was performed, comparing the corpus callosum areas between the previously established groups.
Clinical, Laboratory, and MR Imaging Data
The clinical evaluation of the 21 patients with KS, including age, form of inheritance, molecular analysis, and clinical tests for olfactory disturbance and MM is shown in on-line Tables 1 and 2. These tables also show the results of rhinencephalon evaluation by using MR imaging and findings of renal sonography.
Molecular analysis was performed in previous studies9,26 and showed the presence of a mutation of the KAL1 gene in 4 patients, the FGFR1 gene in 3 patients, and the PROKR2 gene in 1 patient. The Smell Identification Test was performed in 20 patients, indicating anosmia in 14 patients and moderate hyposmia in 4. One patient did not undergo the test because of a cognitive deficit, but reports of hyposmia/anosmia were confirmed by parent testimony. MM, evaluated in all patients, were significantly observed in 9 subjects.
Rhinencephalon Alterations
Aplasia or hypoplasia was found in 18 subjects. Among the patients with KS, 3 had normal examination findings, presenting olfactory bulbs and sulci dimensions similar to those of controls; however, they presented moderate hyposmia in the smell test and, therefore, were included in the study.
On-line Tables 3 and 4 show all regions of increased and decreased volumes of gray and white matter, respectively, as determined in the optimized VBM by SPM2 software, when comparing pooled data for each of the previously defined groups.
Considering our hypothesis a priori, we found some areas of altered gray matter volume. When individually compared with controls, groups II and III showed different areas of increased volume. In group II, there were 2 areas: 1 in the left precentral gyrus, Brodmann area 4, and another cluster in the left postcentral gyrus, Brodmann area 3, though in group III comparison with controls, the study demonstrated 2 clusters, 1 in the left frontal lobe, Brodmann area 6, and the other in the right precentral gyrus, Brodmann area 4. In the direct comparison between groups II and III, no area of altered gray matter was demonstrated. All other areas of altered gray matter volume, not related to our hypothesis a priori, did not survive correction for multiple comparisons at a P = .05 threshold; therefore, because they were unpredicted findings, we did not consider them significant.
Figures 1 and 2 show all brain regions of increased (orange/red) and decreased (blue) gray matter volume in patients with KS with and without MM, respectively, compared with control subjects.
Fig 1.
Regional cortical gray matter volume increase (orange/red) and reduction (blue) in patients with KS and MM relative to control subjects. Significant voxels (height threshold of P < .001, uncorrected for multiple comparisons and an extent threshold of 25 voxels) are superimposed on selected sections of spatially normalized MR images from a control subject. With the hypothesis a priori, areas of increased gray matter are seen around the left central sulcus, in the primary motor cortex, Brodmann area 4 (the cluster with 122 voxels), and the primary somatosensory cortex, area 3 (the cluster with 93 voxels).
Regional cortical gray matter volume increase (orange/red) and reduction (blue) in patients with KS without MM relative to control subjects. Significant voxels (height threshold of P < .001, uncorrected for multiple comparisons and an extent threshold of 25 voxels) are superimposed on selected sections of spatially normalized MR images from a control subject. With the hypothesis a priori, areas of increased gray matter are seen in the left frontal lobe, Brodmann area 6 (the cluster with 304 voxels), and in the right precentral gyrus, contralateral area 4 (the cluster with 27 voxels).
White Matter
The VBM analysis showed many areas of altered white matter volume containing more than 25 voxels with Z = 3.09, but no area survived correction for multiple comparisons at a P = .05 threshold, and no area was demonstrated involving the corpus callosum, internal capsule, midbrain, pons, or medulla oblongata. Major areas shown in the statistical parametric map analysis comprise clusters of reduced white matter in the frontal lobes of the patients in group III, compared with controls. In the group II versus group III comparison, no significant difference was observed.
We did not find significant differences in the corpus callosum midsagittal area when applying individual t tests for each group comparison and considering P < .05. Corpus callosum mean areas and SDs were the following: control group, 641.9 ± 14.87 mm2; group I, 620.3 ± 17.17 mm2; group II, 636.3 ± 30.23 mm2; group III, 596.5 ± 16.66 mm2. The t tests showed the following: group I versus controls, P = .20; group II versus controls, P = .87; group III versus controls, P = .06; and group II versus group III, P = .27.
In this study, we evaluated 21 patients with KS, and all patients showed altered findings on smell tests, mostly presenting anosmia. Three patients with moderate hyposmia showed normal MR imaging findings, which do not exclude a KS diagnosis.27-29 Nine individuals (43%) presented with MM and 7 presented with an X-linked inheritance pattern. Gene mutations were found in 8 (36%) patients.9 These data are similar to those found by other authors.13 Genitourinary tract abnormality was observed in 5 (26%), all patients within the synkinetic group, with 2 patients presenting the same KAL1 mutation, representing the classic X-linked KS phenotype (ie, hypogonadotropic hypogonadism, anosmia, MM, and renal aplasia).8,28
We can emphasize 3 main findings in the VBM study: First, no area of white matter increased volume in the projection of the corticospinal tract was demonstrated in patients with KS, even in the group with MM. Second, the VBM showed no difference in the corpus callosum between the groups, as well as the region-of interest analysis of the corpus callosum area in the sagittal midline. Third, related to our hypothesis a priori, some areas of gray matter volume involving the motor cortex were demonstrated to be altered in a different manner in patients with and without MM.
The association between MM and hypogonadotropic hypogonadism with anosmia was first described in 1978.30 The authors suggested that uncrossed pyramidal tract fibers could be a major pathogenic factor for the occurrence of congenital MM. In a previous study, a deficient inhibitory mechanism between the right and left supplemental motor cortex was suggested as the MM etiology in patients presenting corpus callosum agenesis.31 In 1985, in a study of children with congenital hemiparesis, the authors proposed that the association between incomplete maturation of the corpus callosum and a deficiency in the crossing of pyramidal tract fibers would be responsible for the pathologic persistence of MM, therefore suggesting a merger of the previous 2 main hypotheses.12
Our analysis showed no significant altered white matter area when comparing the groups with and without MM. The previous study by using VBM in KS22 demonstrated the presence of 2 symmetric tracts of increased white matter attenuation, extending from the lower limb of the internal capsule and laterally through the midbrain toward the pons, in patients with the X-linked form with MM, suggesting a bilateral corticospinal tract hypertrophy involvement in its etiology. This study was in agreement with previous neurophysiologic reports.13 Hence, our results did not reproduce the previous MR imaging structural findings regarding corticospinal tract alterations in patients with KS with MM. Possible explanations for the different findings regarding white matter alterations identified in KS by using VBM include differences in the studied populations, differences inherent to the preprocessing method used (conventional versus optimized VBM), and the lack of structural changes that can be associated with altered motor function in our population of patients with KS and MM.
No volume alteration in the corpus callosum was found. This is in accordance with the study by Quinton et al.28 The prior study using conventional VBM in white matter showed hypertrophy of the corpus callosum in KS groups with and without MM, but no significant difference between the groups, therefore excluding a possible association between MM and corpus callosum alterations.22
Beyond the 2 main hypotheses correlating MM with an uncrossed pyramidal tract and/or a deficient transcallosal inhibitory mechanism, further studies in patients with KS using different techniques, such as positron-emission tomography14 and functional MR imaging,32 demonstrated the relationship of other structures and MM, including the primary motor cortex bilaterally, sensorimotor cortices, and supplemental motor areas near the midline.33 Besides those in patients with KS, other studies with different clinical conditions, such as the congenital form of synkinesia, Parkinson disease, and poststroke, have proposed a more complex mechanism in MM etiology.34-36
No areas of difference in gray matter volume were demonstrated when comparing patients with and without MM. Patients with KS and MM presented 2 areas of increased gray matter around the left central sulcus, the primary motor cortex (Brodmann area 4), and the primary somatosensory cortex (area 3), compared with control group. This alteration is in accordance with the hypothesis of involvement of the dominant motor cortex related to the afferent and efferent motor pathways in the MM pathomechanism and could suggest the presence of hypertrophy as a secondary change to the deficient pyramidal decussation. On the other hand, compared with controls, patients with KS without MM presented 2 different areas of increased gray matter volume related to the motor cortex, the biggest one in the left supplementary motor cortex, Brodmann area 6. These data suggest more complex mechanisms involved in the presence or absence of MM in patients with KS. Even without differences in white and gray matter volume between both groups of patients with KS (with and without MM), different findings in gray matter volume in each KS group compared with controls can be considered as an indirect evidence of gray matter structural alterations in patients with KS with and without MM.
Rhinencephalon alterations of KS identified in MR imaging are well established. Olfactory afferents, especially from olfactory tracts, not only make connections with the olfactory cortex (Brodmann 34) but also have interactions with the limbic system, piriform cortex, including the amygdala, parahippocampal gyrus, and lateral hypothalamus, and the hippocampus, contributing memory and learning mechanisms.28 Indeed, neuropsychological developmental alterations have already been described in KS, because the original study of Kallmann et al37 and those of other authors observed association of KS with psychiatric disorders and mental handicaps.38,39 In our study, a complete structured psychiatric assessment of all patients was not carried out; however it was possible to identify 3 patients with psychiatric disorders, including 2 with schizophrenia and 1 who had an acute psychotic manifestation. Many other areas of gray and white matter volumes were significantly altered for a height threshold of P < .001, but they were not directly associated with our hypothesis a priori or did not survive multiple variations correction. Different study approaches would be necessary to correlate these altered areas with olfaction disturbances or neuropsychiatric disorders, which are being considered by the authors as possible future projects.
An isolated GnRH deficiency presenting as hypogonadotropic hypogonadism with or without anosmia encompasses a broad spectrum of phenotypes, and many questions remain unanswered regarding the fascinating neurobiologic model presented by KS.1 Recent studies in KS have demonstrated the presence of novel mutations involving new genes, as well as digenic mutations, acting in a synergic way to account for phenotypic determination.26,40 The variable genotype observed in patients with KS might modulate not only endocrine symptoms but also neurologic features, including the presence of MM.
Study Limitations
Although the automated approach of VBM has advantages over traditional region of interest–based methods, false-positive or false-negative findings might arise from the changes in the shape or displacement of structures in the course of spatial normalization. The optimized VBM is an attempt to minimize this problem.20
We have an acceptable sample size when considering all patients with KS,21 but for the MM investigation, it was necessary to split the sample into smaller groups, which could reduce the statistical power of our test and could be responsible for the lack of alterations when comparing groups II and III and could also result in missing possible additional areas of abnormalities in the other comparisons. To avoid reducing the sample size, we kept 2 young subjects in group III, with the 11- and 14-year-old children. To our knowledge, the role and accuracy of VBM in nonadult populations are still not well documented.
The purpose of this study was to use optimized VBM to investigate white and gray matter volume changes in the well-established genotypic and phenotypic status of the KS population to elucidate the cause of MM, present in part of these patients. Our study did not show significant changes in white matter but showed alterations in gray matter involving the motor cortex in a different manner in patients with KS with and without MM. These alterations are in keeping with a hypertrophic response to a deficient pyramidal decussation in patients with KS and MM. In addition, gray matter alterations were observed in patients without MM, which can represent more complex mechanisms determining the presence or absence of this symptom.
We thank Heather F. Olson, PhD, and Donald R. Short for reviewing the manuscript text.
This work was supported by a grant from Fundação de Amparo a Pesquisa do Estado de São Paulo.
indicates article with supplemental on-line tables
Seminara SB, Hayes FJ, Crowley WF Jr, et al. Gonadotropin-releasing hormone deficiency in the human (idiopathic hypogonadotropic hypogonadism and Kallmann's syndrome): pathophysiological and genetic considerations. Endocr Rev 1998;19:521–39
Schwanzel-Fukuda M, Bick D, Pfaff DW. Luteinizing hormone-releasing hormone (LHRH)-expressing cells do not migrate normally in an inherited hypogonadal (Kallmann) syndrome. Brain Res Mol Brain Res 1989;6:311–26
Hayes FJ, Seminara SB, Crowley WF Jr. Hypogonadotropic hypogonadism. Endocrinol Metab Clin North Am 1998;27:739–63, vii
Franco B, Guioli S, Pragliola A, et al. A gene deleted in Kallmann's syndrome shares homology with neural cell adhesion and axonal path-finding molecules. Nature 1991;353:529–36
Pitteloud N, Acierno JS Jr, Meysing A, et al. Mutations in fibroblast growth factor receptor 1 cause both Kallmann syndrome and normosmic idiopathic hypogonadotropic hypogonadism. Proc Natl Acad Sci U S A 2006;103:6281–86. Epub 2006 Apr 10
Matsumoto S, Yamazaki C, Masumoto KH, et al. Abnormal development of the olfactory bulb and reproductive system in mice lacking prokineticin receptor PKR2. Proc Natl Acad Sci U S A 2006;103:4140–45. Epub 2006 Mar 2
Quinton R, Duke VM, Robertson A, et al. Idiopathic gonadotrophin deficiency: genetic questions addressed through phenotypic characterization. Clin Endocrinol (Oxf) 2001;55:163–74
Sato N, Katsumata N, Kagami M, et al. Clinical assessment and mutation analysis of Kallmann syndrome 1 (KAL1) and fibroblast growth factor receptor 1 (FGFR1, or KAL2) in five families and 18 sporadic patients. J Clin Endocrinol Metab 2004;89:1079–88
Versiani BR, Trarbach E, Koenigkam-Santos M, et al. Clinical assessment and molecular analysis of GnRHR and KAL1 genes in males with idiopathic hypogonadotrophic hypogonadism. Clin Endocrinol (Oxf) 2007;66:173–79
Connolly K, Stratton P. Developmental changes in associated movements. Dev Med Child Neurol 1968;10:49–56
Mayston MJ, Harrison LM, Stephens JA. A neurophysiological study of mirror movements in adults and children. Ann Neurol 1999;45:583–94
Nass R. Mirror movement asymmetries in congenital hemiparesis: the inhibition hypothesis revisited. Neurology 1985;35:1059–62
Mayston MJ, Harrison LM, Quinton R, et al. Mirror movements in X-linked Kallmann's syndrome. I. A neurophysiological study. Brain 1997;120 (Pt 7):1199–216
Krams M, Quinton R, Mayston MJ, et al. Mirror movements in X-linked Kallmann's syndrome. II. A PET study. Brain 1997;120 (Pt 7):1217–28
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Kubicki M, Shenton ME, Salisbury DF, et al. Voxel-based morphometric analysis of gray matter in first episode schizophrenia. Neuroimage 2002;17:1711–19
Karas GB, Burton EJ, Rombouts SA, et al. A comprehensive study of gray matter loss in patients with Alzheimer's disease using optimized voxel-based morphometry. Neuroimage 2003;18:895–907
Bernasconi N, Duchesne S, Janke A, et al. Whole-brain voxel-based statistical analysis of gray matter and white matter in temporal lobe epilepsy. Neuroimage 2004;23:717–23
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McMillan AB, Hermann BP, Johnson SC, et al. Voxel-based morphometry of unilateral temporal lobe epilepsy reveals abnormalities in cerebral white matter. Neuroimage 2004;23:167–74
Krams M, Quinton R, Ashburner J, et al. Kallmann's syndrome: mirror movements associated with bilateral corticospinal tract hypertrophy. Neurology 1999;52:816–22
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Trarbach EB, Costa EM, Versiani B, et al. Novel fibroblast growth factor receptor 1 mutations in patients with congenital hypogonadotropic hypogonadism with and without anosmia. J Clin Endocrinol Metab 2006;91:4006–12
Vogl TJ, Stemmler J, Heye B, et al. Kallman syndrome versus idiopathic hypogonadotropic hypogonadism at MR imaging. Radiology 1994;191:53–57
Quinton R, Duke VM, de Zoysa PA, et al. The neuroradiology of Kallmann's syndrome: a genotypic and phenotypic analysis. J Clin Endocrinol Metab 1996;81:3010–17
Madan R, Sawlani V, Gupta S, et al. MRI findings in Kallmann syndrome. Neurol India 2004;52:501–03
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Received March 25, 2008.
Accepted after revision May 14, 2008.
Copyright © American Society of Neuroradiology


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i know what you need, i know just the woman, yes she will sit there and just stare at you, wont mumble a word, if you say stay here until i return she will, if you say ,dont say a word, she will, she wont spend your money, she wont complain, she'll listen to your everyword without interruption, you know why? because she's the woman you want, but you'll have to buy plenty of airfreshner, because you'll only find her in the graveyard, dig her up and take here home to poppa, just the kind of girl to take home to momma.
Great WW post…it's so sad to think of all of those young men and women we have lost over the past seven years in Iraq.
I hadn't heard of the Wednesday Hero blogroll. Sounds like a great thing, so I'll be sure to check it out!
…Mass Media Podpeople Hivemind orgasms.
Are The Thugs Taking Over America?
Does John McCain Know How Many Houses His Wife Owns?
Let's be honest, at my age, the drinking age isn't anything I really care about. I think I have been carded once in the last 10 or 15 years.
Obama and his flock of acolytes have consistently portrayed him as the younger, hipper candidate. The candidate of change. The fresh wind in the sour air of politics, the new voice. Someone not a part of politics as usual.
"I mean, you've got the first sort of mainstream African-American who is articulate and bright and clean and a nice-looking guy. I mean, that's a story-book, man," Biden on Obama a few months back. Now he's your boss stupid.
What do the words clean, articulate, bright and African American have in common?


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Spied – Nissan Sunny Automatic (CVT) sedan in Bangalore
Mohammed Asrar March 21, 2012 Nissan, Spyshots, Upcoming Cars 1 Comment
Japanese auto giant, Nissan India is speculated to launch a new CVT (continuously variable transmission) auto transmission version of its popular mid size sedan Nissan Sunny. Now the car has been spotted by the Team-Bhpian near Cubbon Park in Bangalore doing the testing rounds. From the looks of it, the diesel badging absent on the Sunny caught testing indicates that Nissan might be launching the automatic version of the Sunny with a petrol engine.
It is expected that the same 97 Bhp petrol engine of the manual transmission version with a peak torque of 134 Nm. Moreover, the cost factor may prevent the company from adding the automatic transmission in the line-up of already expensive diesel version of the car.
Nissan does sell the Sunny sedan with the continuously variable transmission(CVT) in the United States. It has been speculated that the same CVT transmission gearbox will be incorporated in the Indian version of the Sunny AT. A CVT gearbox is different from conventional automatic gearboxes, which use a torque convertor. The CVT gearbox uses a complex array of weights and belts, much like the Honda Activa and Suzuki Access 125 automatic scooters of this world.
The car was launched in India in December last year and it has been receiving a very good response from the Indian buyers. Now with the CVT automatic gearbox, the Sunny will only become more convenient than ever before for driving in crowded city conditions. The other automatic cars in the Indian C-segment car space are the all new Honda City, the Volkswagen Vento, the all new Ford Fiesta, the Hyundai Verna Fluidic and the Skoda Rapid. Of these, only the Verna is available with an automatic transmission for the diesel engined variants.
Also see – Nissan India launches Sunny sedan at Rs 5.78 Lakhs
Source – Team-Bhp
2012 Mercedes-Benz SLS AMG Roadster Revealed
RENDERED: Tata's upcoming SUV by Theophilus Chin with influence from Land Rover surface
Spied – Audi Q5 facelift caught testing in Mumbai, yet again!


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EDITORIAL - A constitutional obligation to children
Published:Thursday | April 5, 2012 | 12:00 AM
Deika Morrison's Crayons Count initiative is proving a good prism through which to view the dysfunction in Jamaica's early-childhood education system and why it makes sense that it is fixed.
Ms Morrison has now done another good turn by reminding the Jamaican authorities that this is not merely a moral issue. It is a contractually entrenched obligation the Jamaican state has with its children.
Herein lies the Government's argument for the politically difficult decision, that is, rebalancing the education budget, it may have to take to fulfil its commitment.
A year ago, as Ms Morrison reminded, Jamaica's Parliament approved a new Charter of Rights, replacing the old section three of the Constitution, to give greater clarity to the rights and freedoms of its citizens.
Section 13 (k) of the Charter declares it a right of every child, "who is a citizen of Jamaica, to publicly funded tuition in a public educational institution at the pre-primary and primary levels".
On the basis of this binding obligation, Earl Witter, the public defender, whose mandate includes protecting citizens' rights from infringement by the state, could possibly find cause for action on behalf of thousands of children who do not now enjoy this right. Conceivably, too, individual parents and caregivers could, on their own accord, institute action against the state.
Given the recency of the undertaking, however, this newspaper would not, at this stage, promote such action. Nonetheless, we believe it incumbent on the Government to declare a timetable for the broad fulfilment of the letter and spirit of its obligation.
This does not mean that we expect that, in short order, every Jamaican child between the ages of three and 12 to be in institutions where all costs are met by the state. However, we expect that all children, at the earliest stage of their educational development, should, notwithstanding their social and economic antecedents, be assured of access to institutions that have the capacity for delivering a high, professional standard of stimulation without cost being a barrier.
But, as we have previously noted in these columns, Jamaica's early-childhood education is provided primarily by nearly 3,000 community-based basic schools. They are mostly in run-down buildings with too many children and too few teachers, most of whom are untrained, under-trained and poorly paid. At near minimum-wage pay, those who get trained have little incentive to remain.
Difficult to solve
Finding a solution has been difficult. We believe there is a way to start.
Jamaica allocates $2.1 billion, a mere three per cent of its education budget, to the early-childhood sector. Most this goes as grants to basic schools. It is far from enough. This shows in the poor quality of delivery from the early-childhood sector. Perhaps half the children it prepares are not ready for primary education.
The estimate is that it needs an additional $8 billion a year to bring the sector up to acceptable standards.
One potential source of some of this money in the short term is by rebalancing the education budget, by reallocating to early-childhood education some of the 15 per cent of the education ministry's spending that now goes to the tertiary sector.
The Government has a compelling argument in support of such a move: funding early-childhood and primary education is a constitutional obligation.
The opinions on this page, except for the above, do not necessarily reflect the views of The Gleaner. To respond to a Gleaner editorial, email us: editor@gleanerjm.com or fax: 922-6223. Responses should be no longer than 400 words. Not all responses will be published.
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California Wildfires Rage, Death Toll Climbs to 31
By VOA News
Sheriff's deputies recover the remains of a victim of the Camp Fire, Nov. 10, 2018, in Paradise, California.
Wildfires raged at both ends of California on Sunday, with the deadly infernos barely contained and strong winds and dry conditions in the forecast.
The death toll stood at 31 and was likely to increase as rescue workers reached vast regions left in charred ruins. The Northern California sheriff also reported that 228 people are still unaccounted for in the massive wildfire.
Thousands of people have evacuated with what little of their life's possession they could escape with.
Authorities say one of the California wildfires is about 25 percent contained and the other only 10 percent.
More than 8,000 firefighters are battling the Woolsey Fire and the Hill Fire in southern California, and the Camp Fire, in the northern part of the state, that erupted Thursday fueled by drought conditions and wind.
Officials said the Camp Fire has become the most destructive wildfire in state history, and the third deadliest.
Previously, the Tubbs Fire, which burned nearly 16,000 hectares in Lake, Napa, and Sonoma counties in 2017, had been considered the most destructive wildfire in state history. The Tubbs Fire killed 22 people and destroyed more than 5,500 structures.
The Butte County Sheriff's office said the Camp Fire victims were mostly found dead inside or near their cars. The sudden evacuation led to highway gridlock, forcing some to flee on foot.
Officials said the fire has destroyed 6,453 homes and another 260 commercial structures and has grown to 404 square kilometers.
Charred property is seen in the Seminole Springs M
Charred property is seen in the Seminole Springs Mobile Home Park, Nov. 11, 2018, after a wildfire tore through the area in Agoura Hills, California.
The blaze nearly quadrupled Thursday into Friday. Officials say the blaze is only five percent contained.
Evacuations were ordered for the east side of the neighboring town of Chico, a city of about 93,000 people, as flames from the blaze were being driven by 56 kph winds.
The Woolsey Fire is threatening about 75,000 homes in Ventura County, northwest of Los Angeles.
Two arrests were made for looting in Ventura County.
L.A. County Sheriff's Department Chief John Benedict said Saturday, "There is zero tolerance for any looting."
Ventura county is also the location of a mass shooting this week that killed 12 people.
The mayor of the city of Thousand Oaks, where the mass shooting took place, says three-quarters of his city is under fire evacuation orders.
President weighs in
U.S. President Donald Trump, in France for the centenary remembrance of the end of World War I, continued to blame state forest managers for the devastation, but did not mention years of drought in the most populous U.S. state.
"With proper Forest Management, we can stop the devastation constantly going on in California. Get Smart!" Trump said on Twitter.
With proper Forest Management, we can stop the devastation constantly going on in California. Get Smart!
— Donald J. Trump (@realDonaldTrump) November 11, 2018
Earlier, he warned California residents that the "fires are expanding very, very quickly (in some cases 80-100 acres a minute). If people don't evacuate quickly, they risk being overtaken by the fire. Please listen to evacuation orders from State and local officials!"
He said 4,000 firefighters are battling the Camp and Woolsey fires that had burned nearly 70,000 hectares. "Our hearts are with those fighting the fires, the 52,000 who have evacuated," and the families of those who have been killed. "The destruction is catastrophic. God Bless them all."
A religious statue stands amongst destroyed proper
A religious statue stands amongst destroyed properties in the Seminole Springs Mobile Home Park, Nov. 11, 2018, after wildfires tore through the neighborhood in Agoura Hills, California.
But he contended, "There is no reason for these massive, deadly and costly forest fires in California except that forest management is so poor. Billions of dollars are given each year, with so many lives lost, all because of gross mismanagement of the forests. Remedy now, or no more Fed payments!
But authorities in California disputed Trump's assessment.
Brian Rice, president of California Professional Firefighters, said, "...nearly 60 percent of California forests are under federal management ... It is the federal government that has chosen to divert resources away from forest management, not California ... At this desperate time, we would encourage the president to offer support in word and deed, instead of recrimination and blame."
On Sunday, Rice told CNN that Trump's statement was "stupid" and "callous" and did not take into account California's seven-year drought.
LeRoy Westerling, a climate and fire scientist at University of California Merced, told the San Francisco Chronicle Trump's tweets oversimplified the issue in California.
"To have a president come out and say it's all because of forest management is ridiculous. It completely ignores the dynamic of what's going on around us," he told the Chronicle. He said rising temperatures and longer spells of dry weather were behind an increase in not only the number of wildfires but their ferocity as well.


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Home/More/Phones/According to an alleged Geekbench listing, the OnePlus Nord 2T would be equipped with a MediaTek Dimensity 1300 SoC.
TheTechTornado Send an email May 10, 2022
The OnePlus Nord 2T could get an 8GB RAM configuration.
The OnePlus Nord 2T has been circulating for quite some time. The handset has supposedly been seen on the Geekbench benchmarking website, hinting at its main specifications, ahead of its public introduction. The MediaTek Dimensity 1300 SoC is rumoured to power the next OnePlus Nord 2T. It might work on Android 12. The entry on Geekbench shows that the forthcoming OnePlus phone would have up to 12GB of RAM, confirming previous rumours. The phone is expected to supersede the OnePlus Nord 2, which was released in India in July of last year.
The OnePlus Nord 2T with model number CPH2399 is allegedly listed on Geekbench, according to 91Mobiles. The OnePlus Nord series phone will sport an octa-core MediaTek Dimensity 1300 SoC with one high-performance core clocked at 3.00GHz, three cores clocked at 2.60GHz, and four cores clocked at 2.00GHz, according to the listing. According to the listing, the phone has 7.29GB of memory. On paper, this translates to 8GB of RAM. On the OnePlus Nord 2T, it also suggests Android 12.
The handset purportedly scored 474 points in single-core testing and 2,933 points in multi-core testing on the Geekbench website. Because the mentioned results could be from a prototype, the phone's actual performance may vary. At the time of filing the post, Gadgets 360 was unable to locate the entry on the Geekbench website.
Specifications The OnePlus Nord 2T has previously been leaked. The phone was recently discovered online in an unboxing video that revealed its design, pricing, and specifications. The 12GB RAM + 256GB storage option is estimated to cost roughly Rs. 30,000.
The phone is claimed to include a 6.43-inch full-HD+ flexible AMOLED (1,080X2,400 pixels) display with a 90Hz refresh rate and compatibility for HDR10+. The MediaTek Dimensity 1300 SoC is claimed to be powering it, along with up to 12GB of LPDDR4x RAM. The phone also has a triple rear camera system with a 50-megapixel Sony IMX766 sensor, a 32-megapixel selfie sensor, and up to 256GB of onboard storage. It is expected to have a 4,500mAh battery with an output of 80W SuperVOOC charging support.
At a company-wide meeting, Twitter CEO Jack Dorsey meets employee outrage at Musk's assaults.
ONDC, India's open ecommerce network, may welcome Flipkart, RIL, and Amazon.


It had to happen coming in December the first sitcom about the UN - are we ready for this???
Ahh over the years i am sure many of us have thought it would be fun to write a sitcom about what happens at the UN....I even started to draft a pitch once but then I wasn't sure it would be good for multilateralism to finish it.
Its clear we are in a difficult period and would laughing at some of the things that go on at the UN be a good idea? I have to say I pulled back.
Over the years there have been a few examples of good films where the UN has been central. There was a good TV series two episodes called Burn Up (2008) with Bradley Whitford (Josh from west wing) as James 'Mack' Mackintosh with the Business coalition trying to suppress climate change data during a UN Conference on Climate Change. I thought it was a very good attempt at showing what happens...more serious and spy like. After all my car number plate is Felix007. If you haven't seen it well worth renting or buying.
Then there are films like the Interpreter with Nicole Kidman and Sean Penn. here we see political intrigue and deception unfold inside the United Nations, where a U.S. Secret Service agent is assigned to investigate an interpreter who overhears an assassination plot. A great film!!
Benedict Moran: We were in Rio together for a big U.N. climate conference, and over drinks one night with a diplomat friend, we decided to try and make the show happen!"
So its pitched at the VEEP audience or if you are from the UK the 'Thick of It'. Both cringe worthy and funny in the Office humor type.
I can see Fox picking this up and running it on their news channel as truth --- see we told you the UN was like this. If you watch the trailer above I think we can recognize the characters...though i think its unfair on the Canadian Mission. Personally i think they should have gone for not a real country but it is first for Canadian TV so I guess that is why.
As both of the writers have been around the UN expect many of the stories we are all well aware of and cringe to find their way onto the series...in some way or another.
If the show has some depth and isn't all fun and silliness (and if the characters don't talk too fast ... has anyone else noticed this? the older I get, the faster everyone else talks!), it's going to be worth watching.


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Kitchen, Newest Kitchen Ideas was posted February 21, 2018 at 2:35 pm by Erinnsbeauty.com . More over Newest Kitchen Ideas has viewed by 7973 visitor.


text:
La puerta en el muro (The Door in the Wall) es un cuento del escritor inglés Herbert George Wells, publicado por primera vez en 1911 en el libro The Door in the Wall and Other Stories. Trata sobre un hombre, Lionel Wallace, que, en un momento de intimidad con su mejor amigo, le cuenta un secreto que ha marcado toda su vida desde que tenía cinco años de vida

Argumento

El secreto de Lionel Wallace no es otro que una puerta verde en un muro blanco, puerta que atravesó cuando tenía cinco años de edad y donde descubrió la más absoluta felicidad, en forma de un jardín preciosísimo habitado por panteras y niñas de rizos rubios y por los mejores compañeros de juegos que un niño podía desear. Pero todo tiene un final, y tras un periodo de tiempo que no puede recordar, es devuelto a la vida real con una añoranza terrible de ese paraíso y aunque intenta con todas sus fuerzas, tanto hacerse entender por los adultos como de encontrar de nuevo la puerta verde, será en vano.

Luego, Wallace crece. Se forja una brillante carrera pública. Se convierte en un reputado miembro del gabinete británico. Pero, durante el rumor de la vida pública exitosa, Wallace vive una existencia paralela. Otra vida secreta, disimulada, silenciada, en la que la puerta en el muro regresa con su promesa de un mundo más vivo y auténtico. Pero el jardín encantado es la existencia libre de la cárcel temporal; de la historia replegada sobre sí misma. En su devenir adulto, Wallace es prisionero de su presente histórico, de su temporalidad más inmediata. Cuando el humano pierde los ojos para lo que rebasa el tiempo, debe resignarse a deambular entre puertas cerradas y muros infranqueables.

A lo largo de su vida aprenderá a vivir con la desesperanza de nunca más poder encontrar su misteriosa puerta, hasta que, súbitamente y sin ninguna explicación, ésta se le vuelve a aparecer en determinados momentos de su vida, en especial aquellos momentos donde acciones importantes para su futuro están teniendo lugar y dónde debe de "elegir" si traspasar el mágico umbral o cumplir con lo que supone es su obligación en el mundo. ¿Qué es lo que elige y qué es aquello que le ha llevado a su actual situación desesperada?

La puerta en el muro examina un tema el cual Wells ha visitado repetidamente en su producción literaria: el contraste entre la estética y la ciencia y la dificultad de escoger entre ambas; el mismo Wells a la vez estudió ciencias y escribía ficción. El protagonista, Lionel Wallace, posee un vívida imaginación pero trabaja como político, mundo en el que se le considera extremadamente racional. La historia sugiere tanto la magia como el peligro de la nostalgia de un tiempo pasado. Es una historia sobre el político Wallace quien, creciendo en un hogar triste, descubre una puerta en un muro que conduce a un jardín encantado. La dicotomía recurrente entre ciencia y arte es parte de un contraste más amplio entre los elementos racionales e imaginativos de la experiencia. La incapacidad de Wallace para tender un puente entre su imaginario y su raciocinio es el que le conducirá a la muerte.

Adaptaciones cinematográficas

 Дверь в стене (La puerta en el muro), cortometraje de animación de 1990, producido por Soyuzmultfilm y dirigido por Borís Akulínichev (Борис Акулиничев, n. 1939).
 Ficha en inglés del cortometraje de animación en el sitio Animator.
 Ficha en ruso.

Enlaces externos

 Texto español.
 Texto inglés.
 Guía de estudio de la obra; en inglés.
 El cuento en inglés en LibriVox, en Commons.

Cuentos de H. G. Wells
Cuentos de 1911

redpajama_set_name: RedPajamaWikipedia


Kit® can hardly believe her luck when she wins tickets to a sold-out jazz concert, and a chance to write a news story about it! But when sinister pranks threaten to cancel the show, Kit's research turns into an investigation. Then a valuable trumpet goes missing, and Kit herself is accused of theft. Can Kit prove her innocence and put a stop to the mayhem before the real thief sends the band packing? Includes an "Inside Kit's World" essay about the popularity of jazz and swing music during the Depression.


text:
Federal Gov
State AG
Iowa SC declares chiropractors' proposed class action over
By Robert Lawson | Mar 15, 2017
DES MOINES, Iowa (Legal Newsline) – The Iowa Supreme Court has reversed a district court decision that would have allowed a collective of similarly situated chiropractors to sue a health insurance company over alleged antitrust violations in the state.
Attorneys for the plaintiffs in the district court case Mueller v. Wellmark Inc. cited the Iowa Competition Act, according to court documents. A civil complaint was filed in 2007 by Steven Mueller, a chiropractor who alleged Wellmark breached a contract in a $17,376 billing dispute.
Several other chiropractors joined Mueller in May 2008 to engage in legal action against Wellmark. This included filing an amended petition for claims in a class of Iowa chiropractors who "have billed for services provided to patients enrolled in Wellmark health insurance plans."
According to the decision,the plaintiffs alleged Wellmark "discriminatorily fixed prices for services performed by chiropractors at rates lower than those paid to medical doctors and doctors of osteopathic medicine. Their amended petition alleged violations of Iowa insurance regulatory statutes, the Iowa Competition Law (Iowa Code chapter 553), and a national class-action settlement. The district court, without certifying this case as a class action, granted Wellmark's motions to dismiss and for summary judgment. Plaintiffs appealed."
This led to the case being heard by the court for a first time in 2009. The court reversed the district court's summary judgment dismissing antitrust claims against Wellmark based on the state-action exemption in Iowa Code section 553.6(4) (2009).
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The court remanded the case for further proceedings on plaintiffs' claims under the Iowa Competition Act. Meanwhile, the collective of chiropractors commenced an administrative action in the Iowa Insurance Division to litigate the violations of the insurance regulatory statutes.
"On Dec. 31, 2012, Wellmark moved to dismiss or stay the civil action pending the insurance commissioner's decision in the related administrative action," the Supreme Court's opinion states. The commissioner decided in favor of Wellmark, who had argued the commissioner had primary jurisdiction "because the regulator was better suited to analyze the complex antitrust allegations and any effects on insurance markets," the opinion states.
There was resistance from the plaintiffs who argued that there wasn't a need to await the commissioner's decision because the amended petition alleged "per se" violations. As such, there was no requirement for the regulator's analysis of the market.
According to the court, under a per se violation, an agreement is "so plainly anti-competitive that no elaborate study of the industry is needed to establish . . . illegality." A contrasting rule-of-reason claim "requires plaintiffs to demonstrate that a particular arrangement 'is in fact unreasonable and anti-competitive before it will be found unlawful.'"
The ruling means that proper procedures were not followed and the district court was found to have erred in allowing the case to proceed without class certification in the first place, according to the Supreme Court.
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text:
Because a lifetime is too long to wait!
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a significant modernization of the federal adult system of
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CPSD/NCD Congressional Briefing Oct 28 2019
Posted by: Lauren Camp | Categories: News, Partner Events
The Collaboration to Promote Self-Determination and the National Council on Disability celebrated National Disability Employment Awareness Month with a Congressional Briefing on Monday, October 28 2019.
SUCCESSES OF PEOPLE WITH DISABILITIES TRANSITIONING TO COMPETITIVE INTEGRATED EMPLOYMENT
Attendees learned about competitive integrated employment (CIE), community jobs where people with disabilities work alongside co-workers without disabilities and are paid competitive wages. They also heard success stories about transitioning to CIE from people with disabilities and their families and about states efforts to expand opportunities for CIE. Learn more about CIE at www.integratedemploymentnow.org.
This briefing was presented in collaboration with the House Bipartisan Disabilities Caucus and its co-chairs Rep. Jim Langevin (D-RI) and Rep. Don Young (R-AK), Senator Pat Roberts (R-KS), Senator Bob Casey (D-PA), Senator Jerry Moran (R-KS), Senator Maggie Hassan (D-NH) and Representative Cathy McMorris Rodgers (R-WA).
With generous support from the Autism Society of America and Anthem
Briefing Handouts
CPSD Briefing Program Oct 28Download
CPSD-Who-We-AreDownload
CPSD-Myths-and-TruthsDownload
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I Work We Succeed Campaign Fact Sheet (Acacia McGuire Anderson)Download
Testimony from Kyle and Bill StumpDownload
History of Sheltered Workshops and Employment First in Oregon (Acacia McGuire Anderson)Download
Tad Carroll storyDownload
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Speakers for the Panel
Lekisha Logan is a lifelong resident of Danville, Virginia and graduated from Dan River High School. She works at Dell'Anno's Pizzeria in Danville, where she has worked since 2011 when she transitioned from a sheltered workshop where she was paid subminimum wages. Lekisha started in the dining room cleaning and clearing tables, and now works as a dishwasher. Lekisha has presented at The Arc of Virginia's Annual Convention, sharing her experience in competitive integrated employment. She also has presented to a group of college students at Averett University about the importance of inclusion in all aspects of life.
Joe Carroll, Acacia McGuire Anderson, Lekisah Logan, Eric Cottrell
Eric Cottrell works at Piedmont Regional Feeding Clinic in Danville Virginia, where patients receive therapies to improve eating and health. Eric grew up in Pittsylvania County, Virginia, where he graduated from Chatham High School and later moved to Danville. He has worked in several types of industries, but has always come back to the helping field because his passion is helping people. Eric transitioned to competitive integrated employment from a sheltered workshop where he was paid subminimum wages in 2011. Eric has presented on his experiences to attendees of The Arc of Virginia's Annual Convention and was interviewed for a video on competitive integrated employment created by Virginia Commonwealth University's Rehabilitation Research and Training Center.
Tonya Milling, originally from North Carolina, has worked in the disability field for over 20 years and has a passion for the rights of people with disabilities. Her career brought her to Virginia in 2011, where she joined The Arc of Southside as executive director and led the agency through a transformation from segregated services to inclusive supports that are built around the person and not their disability. At that chapter of The Arc, she and the leadership team successfully closed all of the segregated facility-based programs, which included a group home for 15 people, a sheltered workshop for 130 people, and a private day school serving 30 students with disabilities. She and the leadership team developed and implemented new support services that partner with people with developmental disabilities to build their own lives with the supports they need to live the lives that they choose. In January 2018, Tonya became the executive director of The Arc of Virginia, where she is advocating for change, so that every person with a developmental disability can have access to supports to live their life in their community.
Acacia McGuire Anderson is the Statewide Employment First Coordinator for Oregon. Her role includes overseeing the transformation of Oregon's employment services for people with intellectual and developmental disabilities to focus on community employment and inclusion. Her previous experience includes working as a services coordinator and as a program manager and prior to that a direct support professional for an employment provider in Oregon.
Tad Carroll, pictured above.
Joe Carroll, and his wife Linda, are the parents of Jeremy "Tad" Carroll, a 45 year old man with developmental and other disabilities. The Carrolls have been involved as advocates in the developmental disabilities community, including starting an early intervention program in their community with educators and other parents when Tad was three years old and serving on the boards of The Arc of Oregon and The Arc Mid-Columbia and as a member of the Oregon Council Developmental Disabilities. Tad worked in a sheltered workshop being paid subminimum wages, often earning less than 10 cents an hour, for almost 20 years. Starting in 2017, Tad began working with Vocational Rehabilitation Counselors and his employment team to transition to competitive integrated employment. Tad was hired in November 2018 by a local restaurant delivering meals. He is paid above minimum wage and is paying taxes for the first time in his life. Because of his job, Tad has become more integrated into the local community, improved his communication skills and made new friends.
Bill and Kyle Stumpf
Kyle Stumpf is a 29 year old man from Dubuque, Iowa. Kyle graduated from high school in 2009. After graduation, Kyle was employed in a sheltered workshop earning subminimum wages for approximately four years. In 2014, Kyle was hired at a local franchise for a major pizza chain in Dubuque, where he works alongside co-workers without disabilities and is paid above minimum wage. Kyle just recently celebrated his five year anniversary there. Kyle is also a very active participant in the community. He volunteers and participates in numerous events and recreational activities throughout the community. He has attended statewide conferences on self-advocacy and on competitive integrated employment. He currently attends many political events, telling his story and encouraging candidates to support disability rights.
Bill Stumpf lives in Dubuque, Iowa with his son, Kyle, and is a licensed practical nurse working with people with intellectual disabilities. Prior to pursuing nursing, Bill was employed in a paper factory for 30 years. He became active in the disability movement shortly after his son Kyle, who has Down syndrome, was born in 1990. He has been active on numerous local, state and national organizations over the years. He currently serves on the board for Disability Rights Iowa and is a member of the Iowa Coalition for Integration and Employment. Along with Kyle, Bill has been engaging political candidates at the local, state, and national levels supporting disability rights, including related to voting rights for people with disabilities, healthcare reform, and competitive integrated employment.
Joshua Laird previously worked in a sheltered workshop doing piece work and on an enclave lawn crew, both jobs where he was paid subminimum wages and had no co-workers without disabilities. At the sheltered workshop, he had behavioral challenges, did not communicate much and seldom smiled. Beginning in 2016, Josh began attending a training program to help him transition to competitive integrated employment in anticipation of the sheltered workshop closing. Through this program, Josh expressed an interest in finding a job where he could work outside and independently and was introduced to the manager of a local marina. For the last three years, Josh has been working for the marina three days per week during the months of May through September and has received Certificates of Appreciation after each season. In the last year, Josh has taken a second job working at Salisbury University in the dining services building approximately 20 hours per week. He has enjoyed and is succeeding at this second job too.
Joshua Laird (right).
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By Rebecca Nickols on November 22, 2012 Visit Rebecca's Website.
I'm also thankful for my backyard flock of chickens! In addition to the delicious (and nutritious) eggs they provide, I've enjoyed hours of free entertainment. Each hen has her own unique personality: some will jump onto my lap, while others are convinced that I'm going to harm them in some hideous act of animal cruelty. These interesting and somewhat quirky behaviors blend together somehow and make the flock even more endearing. I've grown much more attached to these "farm animals" than I ever imagined I would when I first entered the world of chicken keeping.
So on this day of poultry pardons, I'm joining the President in officially pardoning my flock… These lucky (free) free-ranging chickens will live out the rest of their lives without fear of an oven or a pot.
Just to make things clear, however, I'm not opposed to raising chickens for meat–it's a great step to live a more self-sufficient and sustainable lifestyle. If you raise your own food (meat), you know exactly how your meal was treated and what it was fed. I admire those who can process their own birds instead of buying commercial chicken at a grocery store or relying on others to package up the meat into acceptable–presentable packages. I just don't have the heart to part with these chickens (aka-pets) that have become a part of our family!
I might be thankful for my chickens, but they haven't a clue how much they have to be thankful for! They're content enjoying their Thanksgiving treats of the fall harvest–pears and pumpkins!


text:
The Mendocino Voice | Mendocino County, CA (https://mendovoice.com/2020/07/university-of-california-agriculture-and-natural-resources-using-100000-grant-to-create-and-grow-wildfire-education-programs-in-mendocino-county/)
Hopland Extension gets $100k grant to provide locally-specific wildfire education programs
By Lana Cohen | July 2, 2020
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View of a ridge from University Road, Hopland
Note: Lana Cohen is a Report For America fellow covering the environment & natural resources for TMV & KZYX. Her position is funded by the Community Foundation of Mendocino, Report for America, & our readers. You can support Lana's work here or email [email protected]. Contact Cohen at LCohen@mendovoice.com. TMV maintains editorial control.
HOPLAND, 6/30/20 — The River Fire came from the northwest corner of the property, where it had been burning in the adjacent Bureau of Land Management lands. It made its way to the 3,000 foot ridge situated on the University of California Agriculture and Natural Resources' Hopland Research Extension Center property. A strong wind blew the fire down into the valley towards the center's buildings and homes. The UC Research Extension's resident shepherd herded the 500 sheep that live on the property to irrigated grassland and the scientists, educators, and researchers that live on the premises evacuated. During the fire, in 2018, two-thirds of the 5,300 acre UC Extension burned. Luckily, none of the buildings on the property were destroyed by the fire.
Hannah Bird, community educator at Hopland Research Extension Center (HREC), happened to be on vacation at the time, but the experience of thinking her home had burned down, and knowing the land she works and lives on was up in flames, changed her understanding of wildfire. "Of course, I don't understand the hurt and pain of actually losing people or property, but I do have a greater sense of how people are affected by fire," said Bird.
Bird decided to apply for a grant that would allow her to provide local students, teachers, and residents with information directly focused on how wildfires behave in this region. She hopes that this knowledge will empower community members and make them feel like they have more agency when dealing with wildfire, which she believes will become increasingly important as climate change continues to grow the frequency and severity of fires.
In her role as community educator at HREC, Bird, along with UC Sierra Foothill Research and Extension Center and scientist Kate Wilkin, wrote a proposal and received a $100,000 education grant from the Environmental Protection Agency (EPA) to teach Califorians about wildfire.
They published the press release announcing the grant earlier this month.
With the funding to back their efforts, they wrote a curriculum created to provide middle school students with knowledge about wildfire in Oak Woodlands. They piloted the lesson plans at Eagle Creek and Pomalita middle schools. Now they are coordinating with the Mendocino County Firesafe Council to translate informational pamphlets into Spanish. In mid-July, they will be offering a virtual teacher training to share their curriculum and knowledge with educators and other interested parties. The training will begin with a 30 minute introductory session on July 14.
Bird clarified that the program is not just for classroom teachers. "Folks that are kind of interested in possibly joining the training series I wouldn't say don't come if you're not an educator, I would say come and we'll find out if there's a good way for you to spread information. It's not about me offering the curriculum. It's about giving teachers the tools so they feel confident teaching about wildfire," Bird continued. "We recognize that our staff here is quite limited, but we feel this is a really important program. The only way for us to extend this is to provide the tools so that other people can share the information. Otherwise we just wouldn't reach as many people."
The hope is that the lessons in the curriculum will allow students to walk away feeling they have some way to make a change and be more prepared for wildfire.
"Living in this community, everybody is affected [by fire]," said Bird. "Everybody has a story of how it [fire] impacted their lives." Bird and her colleagues hope that through education, they can help the community feel like they have more agency when dealing with fire. "Knowledge is great, but not if we don't give you some way to actually use it," said Bird.
The lesson plans are based on a United States Forest Service (USFS) curriculum that has been around for 50 years. Although Bird and her colleagues were impressed by the lesson plans, they saw some gaps. "The lessons are awesome but they hadn't thought about Oak Woodland environments, which is what we find in inland Mendocino," commented Bird.
This is important because the way fires act relates to their ecology. How a fire behaves in a woodland environment is different than somewhere dominated by another species, such as conifers.
In addition to tweaking the Forest Service's curriculum to better suit this region of California, Bird and her team incorporated local, historical, and ecological fire knowledge by consulting tribes neighboring HREC. They also took into consideration the trauma students may have experienced and the anxiety they might have when learning and talking about fire. The first of the curriculum's three lessons focuses on what feelings fire brings up for the students and what they feel comfortable discussing.
Another hallmark of the curriculum is building forest models and setting them on fire in order to learn about fire ecology and physics in a hands-on way.
"When I tell people we're doing lessons about fire with middle schoolers and I say we're actually lighting fire they say 'you are crazy'," recounted Bird. "But scientific studies actually show that the more youth know the less likely they are to deliberately or inadvertently start a fire." Bird believes that the knowledge disseminated through the lessons gives children the opportunity to be responsible.
In addition to creating lesson plans for middle school students, the HREC is working alongside the Mendocino County Fire Safe Council to offer more comprehensive community education. This year, the Fire Safe is working with Ukiah Vecinos en Acción (UVA) to translate existing leaflets and other information about fire into Spanish.
Like most other things, COVID has changed the original plans for this grant, but that hasn't slowed them down. "Lots of things are going on but wildfire isn't going away either," said Bird.
Bird believes that the most important part of all these programs, and especially the program geared towards middle school students, is that those that participate are left with a sense of agency. "We do not want them to feel at the end of the lessons — well wildfire is part of ecology but there's nothing I can do about it," she said "You have to walk out and feel like I have some way I can make a change and feel prepared. That's the key."
You can sign up here for the virtual teacher training program introduction which will take place on July 14 from 11:00AM to 11:30AM.
Hopland Research and Extension Center
River Fire
USFS
Firewood permits for Mendocino National Forest available through September
Structure fire near Little River severely burns one person; no spread into the wildland (updated 9:17)


text:
import Prelude hiding (drop, length, reverse, take)
import Data.Foldable (toList)
import Data.Sequence

swapPos :: Int -> Int -> Seq Char -> Seq Char
swapPos x y string =
  let x' = string `index` x
      y' = string `index` y
  in update x y' $ update y x' string

swapLetter :: Char -> Char -> Seq Char -> Seq Char
swapLetter x y string = do
  letter <- string
  if letter == x then return y
  else if letter == y then return x
  else return letter

rotateLeft :: Int -> Seq Char -> Seq Char
rotateLeft x string =
  let x' = x `mod` length string
  in drop x' string >< take x' string

rotateRight :: Int -> Seq Char -> Seq Char
rotateRight x string =
  let x' = length string - x
  in rotateLeft x' string

basedRotate :: Char -> Seq Char -> Seq Char
basedRotate x string =
  let (Just index) = elemIndexL x string
      times = 1 + index + fromEnum (index >= 4)
  in rotateRight times string

basedRotate' :: Char -> Seq Char -> Seq Char
basedRotate' x string =
  let (Just index) = elemIndexL x string
      times = [7,7,2,6,1,5,0,4] !! index
  in rotateRight times string

reversePos :: Int -> Int -> Seq Char -> Seq Char
reversePos x y string =
  let slice = reverse $ drop x $ take (y + 1) string
  in take x string >< slice >< drop (y + 1) string

move :: Int -> Int -> Seq Char -> Seq Char
move x y string =
  let x' = string `index` x
  in insertAt y x' $ deleteAt x string

parse :: Bool -> [String] -> Seq Char -> Seq Char
parse _ ["swap", "position", x, "with", "position", y] = swapPos (read x) (read y)
parse _ ["swap", "letter", [x], "with", "letter", [y]] = swapLetter x y
parse u ["rotate", "left", x, _] = (if u then rotateRight else rotateLeft) (read x)
parse u ["rotate", "right", x, _] = (if u then rotateLeft else rotateRight) (read x)
parse u ["rotate", "based", "on", "position", "of", "letter", [x]] = (if u then basedRotate' else basedRotate) x
parse _ ["reverse", "positions", x, "through", y] = reversePos (read x) (read y)
parse u ["move", "position", x, "to", "position", y] = (if u then flip move else move) (read x) (read y)

part1 :: String -> String
part1 = toList . foldl (flip ($)) (fromList "abcdefgh") . map (parse False . words) . lines

part2 :: String -> String
part2 = toList . foldr ($) (fromList "fbgdceah") . map (parse True . words) . lines

redpajama_set_name: RedPajamaGithub