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Fabrice GorrecFrançois-Xavier Robert, Claire SeddonSimon Tanley
FUSION formulation
The most efficient components of the three MORPHEUS crystallization screens have been combined into a single 96-condition screen called FUSION. FUSION integrates 17 previous MORPHEUS mixes of additives ("LiNaK", "alkalis", "polyamines", etc.) and two new mixes ("cryopolyols" and "NDSBs"). Mixes of additives were paired to form 96 unique combinations (see some examples in Table 1). FUSION also integrates the four mixes of precipitants and three buffer systems of the original MORPHEUS screen. All components were systematically sampled to formulate an incomplete factorial. The efficiency of FUSION was demonstrated by producing useful crystallization hits with test samples in multiple FUSION conditions (Fig. 1).
For more details about the FUSION screen, please refer to the original publication: Gorrec & Bellini (2022).
Table 1. Examples of crystallization conditions in the FUSION screen. The eight conditions listed are the ones that produced the crystallization hits shown in Fig. 1. In FUSION, there are 81 conditions prepared with two mixes of additives each, such as C6, D6, D8, F11, G5 and G8 shown here. The 15 other FUSION conditions are prepared with only one mix of additives (e.g. H11 and H12), whose concentration is doubled compared with when they are paired with another one. For example, the concentration of the mix "polyamines" is 10 mM in F11 whereas it is 20 mM in H11.
Mix of precipitants
Mix of additives (set 1)
C6 12.5% w/v PEG 1000, 12.5% w/v PEG 3350, 12.5% v/v MPD 0.1 M bicine/Trizma base pH 8.5 30 mM of each LiNaK 20 mM of each monosaccharide 1
D6 10% w/v PEG 20 000, 20% v/v PEG MME 500 0.1 M bicine/Trizma base pH 8.5 30 mM of each LiNaK 20 mM of each monosaccharide 2
D8 10% w/v PEG 4000, 20% v/v glycerol 0.1 M bicine/Trizma base pH 8.5 1 mM of each alkali 20 mM of each monosaccharide 2
F11 10% w/v PEG 4000, 20% v/v glycerol 0.1 M MOPS/HEPES-Na pH 7.5 10 mM of each polyamine 0.5% w/v of each cryopolyol
G5 10% w/v PEG 8000, 20% v/v ethylene glycol 0.1 M bicine/Trizma base pH 8.5 20 mM of each amino acid 0.3% w/v of each NDSB
G8 10% w/v PEG 20 000, 20% v/v PEG MME 500 0.1 M MES/imidazole pH 6.5 1 mM of each alkali 0.3% w/v of each NDSB
H11 10% w/v PEG 20 000, 20% v/v PEG MME 500 0.1 M MES/imidazole pH 6.5 20 mM of each polyamine None
H12 10% w/v PEG 8000, 20% v/v ethylene glycol 0.1 M MES/imidazole pH 6.5 0.4% w/v of each anaesthetic alkaloid None
Figure 1. Examples of initial crystallization hits obtained with FUSION. Diffraction-quality crystals were obtained against eight test samples and are shown here: α-amylase (a), avidin (b), catalase (c), concanavalin A (d), creatine kinase (e), insulin (f), lysozyme (g) and thaumatin (h). The FUSION conditions used are indicated in the bottom right corner of each micrograph.
Optimizing the concentration of the main components
Despite the success of FUSION with test samples, where many diffraction quality crystals could be obtained without further optimization (Fig. 1), in most cases it will be required to optimize crystal growth by setting up modified experiments based on the initial FUSION hits. For this, it is normally required to investigate the impact of varying the concentrations of the main components of the condition that produced that hit, and to observe effects on crystal nucleation and growth.
As with the original MORPHEUS formulation, the simplest way to approach optimization with FUSION is to consider each mix of reagents as a single component. When there are two mixes of additives in a condition, the corresponding stock solutions can also be combined to reduce the number of components and parameters to test and investigate. Because of the systematic nature of the FUSION formulation, the starting ratios between components is always 0.5 mix of precipitants + 0.2 mix of additives from set 1 and/or 2 + 0.1 buffer system + 0.2 water.
At the Laboratory of Molecular Biology, we recommend using the "4-corner solutions" method to produce 2D concentration gradient screens (Fig. 2). The initial step is to prepare 4-corner premixes "A, B, C and D" manually. This is to handle difficult solutions with a relatively large volume range and bypass the liquid-classes programming with automated liquid handling technology. Based on the fixed ratios of stock solutions in FUSION, the formulation of the required 4-corner premixes "A, B, C and D" to vary the concentration of precipitants and additives will typically be as follows:
Solution A: 0.35 mix of precipitants + 0.05 mix of additives from set 1 and 2 + 0.1 buffer system + 0.5 water
Solution B: 0.55 mix of precipitants + 0.05 mix of additives from set 1 and 2 + 0.1 buffer system + 0.3 water
Solution C: 0.35 mix of precipitants + 0.25 mix of additives from set 1 and 2 + 0.1 buffer system + 0.3 water
Solution D: 0.55 mix of precipitants + 0.25 mix of additives from set 1 and 2 + 0.1 buffer system + 0.1 water.
Figure 2. Representation of the 2D linear gradients of concentrations across the standard 96-well plate layout that result from the "4-corner solutions" method. Two linear gradients of concentrations for the two components to be varied are automatically generated by a liquid handler, which dispenses the four solutions "A, B, C and D" at different ratios into the reservoirs of a crystallization plate. Figure adapted from Gorrec & Löwe (2018).
Optimizing the pH
Apart from varying the concentration screen components, the pH is often an important variable that is typically investigated in parallel with the concentrations of precipitants and additives. This can be done by preparing separate 2D concentration gradient screens (Fig. 2), each containing a buffer adjusted to different pH values. Conveniently, the preparation of buffers adjusted to different pH values is made straightforward with the MORPHEUS buffer systems (Table 2).
For more details about the MORPHEUS buffer systems, please refer to the original publication: Gorrec (2009).
Table 2. Recipes for preparing the three MORPHEUS buffer systems as used in the FUSION screen. Buffers are pH-adjusted by mixing 1 M stock solutions of acidic and basic buffer molecules. The table lists volumes of the stock solutions needed to yield 50 ml of buffer mix. The buffer mix preparations should be checked with a pH meter. Please note that a pH meter equipped with a solid-state probe will avoid inaccuracies with Tris-containing buffers, unless explicit corrections are applied when using other probes.
1 M MES (ml)
1 M imidazole (ml)
1 M MOPS (ml)
1 M HEPES-Na (ml)
1 M bicine (ml)
1 M TRIS-base (ml)
"Biasing experiments" to increase chances during optimization
When an additive mix is revealed as being essential during the optimization of an initial hit condition, we recommend adding the additive mix to the sample and then to screen against other crystallization screens. This "biasing" of the sample often increases the yield of useful crystals and can be particularly helpful when a better crystal form is needed through re-screening [Fig. 3(a)]. Conversely, when a precipitant mix is revealed as essential in the initial screen or optimization, a custom-made FUSION screen formulated with a single precipitant mix (instead of the normally used four different ones) can be an efficient approach to additive screening as FUSION combines so many different additives [Fig. 3(b)]. All mixes needed to proceed with optimization work are available commercially as ready-made stock solutions, making this task even more straightforward.
Figure 3. (a) Creatine kinase crystals obtained after "biasing" the sample with 10% of the mix of additives "LiNaK". (b) Insulin crystal resulting from a custom-made FUSION screen prepared with a single MORPHEUS precipitant mix ("precipitant mix 3" integrating PEG 4000 and glycerol).
This work was supported by the Medical Research Council (MRC), as part of United Kingdom Research and Innovation. FUSION is sold by Molecular Dimensions Ltd as "MORPHEUS® FUSION" under an exclusive licence from the MRC and the medical research charity LifeArc.
Gorrec, F. (2009). The MORPHEUS protein crystallization screen. J. Appl. Cryst. 42, 1035–1042.
Gorrec, F. & Bellini, D. (2022). The FUSION protein crystallization screen. J. Appl. Cryst. 55, 310–319.
Gorrec, F. & Löwe, J. (2018). Automated Protocols for Macromolecular Crystallization at the MRC Laboratory of Molecular Biology. J. Vis. Exp. 55790.
Fabrice Gorrec is located at the MRC Laboratory of Molecular Biology (Cambridge, UK). François-Xavier Robert is located at LifeArc (London, UK). Claire Seddon and Simon Tanley are located at Molecular Dimensions (Sheffield, UK).
Correspondence: enquiries@moleculardimensions.com


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Hello all, I thought I'd reach out to see if anyone else going to the games has better info on the Lunar New Year issues with Korail. I have had absolutely no issues reserving rail tickets until right now. They are not allowing anyone to reserve tickets with the Pyeongchang Rail Pass online from Feb 14-18 for the national holiday. They say it will be announced 'later'. I've tried Skyping their customer service several times and there is a severe language barrier. They say you could book tickets at a travel counter by 'asking a friend in Korea' or online. But every time I ask about that I get something different. Once they said that you can use the pass online....and then no it will be all in Korean for Koreans only....and I can't get anyone to tell me if I have to pay extra for this time period or just use the pass. It is getting me no where. I'm worried I will not get to events due to the sheer volume of travelers during a national holiday. Has anyone going found more solid info about this? Many thanks from a concerned fellow traveler.
Well I found a pension close to the freestyle venue. At least I have a place to sleep! Good luck to everyone out there!
Hello KSG. I have yet to find ANY accommodations that are not in Seoul. I know you don't recommend people staying there but do you have any info about hotels? I've contacted the Pyeongchang site several times and they can't seem to even help.
What about the figure 8 hotel on the beach? That can't just be for non-tourists. I'm starting to panic. I called the number on the Pyeongchang website and the tourism people made it sound like it was too early to be looking.
Hello everyone, I've been locked out of my old Gamesbid account so I had to start over with a new name. And thank you in advance to anyone who has suggestions. As we have feared, getting accommodations are extremely difficult for these games. Travel sites have just now opened the dates for the games and there are so few hotels and most say they are already sold out. I've looked at Airbnb and few places are actually close to the two clusters and some are charging thousands a night. I've tried to use Google Maps to no avail- there is little public transportation that comes up. In the transportation thread it was stated that the train to and from Seoul would be $45 USD and there is just no financial way that's a good idea for staying in Seoul the whole time. Has ANYONE been able to get accommodations? If so how did you find them? Side note: I know there are at least 4 new hotels to be built but I can't even find their names to look into booking. Has anyone seen info about this as well?


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Home»US»Stocks Plummet & An ISP Blocks Twitter & Facebook Following Ban Of President
Stocks Plummet & An ISP Blocks Twitter & Facebook Following Ban Of President
Michael Snyder 2021-01-12
Michael Snyder / January 12, 2021
Over the years, the big tech companies have made enormous amounts of money by monetizing discussions about politics. But now that Twitter and Facebook have silenced President Trump and have deeply alienated large portions of their user bases, their stock prices are tumbling. I figured that this would happen, but I didn't anticipate that it would happen this rapidly. To be honest, what we are witnessing is nothing short of breathtaking. For example, at one point on Monday Twitter's market value had fallen by five billion dollars…
As a result of the ban, Twitter stock fell 12 percent on Monday, and the share-price decline wiped $5 billion from the company's $41 billion market capitalization.
According to Business Insider, the stock likely fell because investors are worried that the ban will diminish interest in the platform and lead to boycotts among those who see the decisions as politically motivated and a way to silence conservative voices.
The executives at Twitter may not have liked it, but President Trump was their number one draw by a very wide margin.
And it is very bad business to kill off your number one source of income, but that is exactly what Twitter just did.
So what will Twitter do now with no Trump? This is a question that CNBC's Jim Cramer would very much like an answer to…
"I think that there are a lot of people who literally knew that the president was the most important person, and you had to keep checking him, and then you had to check people who talked about him," Cramer said. "And you just had this endless wave, this web that the president created, and then it was like action and reaction, so I think that the surprise factor of going to Twitter, which was of course the president, is gone!"
In addition to permanently banning Trump, Twitter also decided to ban approximately 70,000 of his followers.
Those bans have alienated millions of other users, and that is a major problem.
With people leaving in droves, Jim Cramer is warning that Twitter desperately needs "a new thesis very, very quickly"…
"Twitter's got to come up with a new thesis very, very quickly because I think they always, they never talked about the power of Trump in bringing in people," he added. "I am telling you the real Donald Trump was a great sales person for Twitter."
Meanwhile, investors are bailing on Facebook as well. In fact, at one point on Monday Facebook's market cap was down 33.6 billion dollars…
Facebook sank as much as 4.5% on Monday as investors continued to balk at the platform's ban of President Donald Trump.
The slide saw $33.6 billion erased from Facebook's market cap at intraday lows. Shares have since pared some losses and now trade about 2.6% lower.
These numbers are so absurd that they are difficult for many people to grasp.
TRENDING: White House Press Secretary: Obama has been Most Transparent President in US History
How in the world can a single company suddenly be worth 33,600,000,000 less dollars than it was yesterday?
Apparently, Facebook has decided that it doesn't want conservatives on the platform anymore, because they keep alienating conservatives over and over again.
Sadly, we just learned that Facebook has even decided to start going after Ron Paul…
Ron Paul shared on Twitter that Facebook had temporarily blocked his account for "violating community standards" but he had no idea why. He posted that his account had not received a warning prior, despite the message saying that his account had committed multiple violations.
Facebook will never be the same after this.
Yes, the company will still be around, but the user base is going to be substantially smaller.
On Monday, I had to smile when I learned that an Internet service provider in Idaho has decided to block Twitter and Facebook unless their customers specifically request that they be unblocked.
What a great idea. If more Internet service providers started doing the same thing, the big tech companies would start backing off really fast.
And we aren't just seeing a backlash here in the United States. Even German Chancellor Angela Merkel is speaking out about how wrong all of this censorship is…
German Chancellor Angela Merkel said Monday through chief spokesman Steffen Seibert that Twitter's Trump ban is a problem and that corporations should not be messing with free speech, Fortune reported.
"The chancellor sees the complete closing down of the account of an elected president as problematic," Seibert said, according to Fortune, adding that the freedom of speech "can be interfered with, but by law and within the framework defined by the legislature — not according to a corporate decision."
The European Union is not exactly a bastion of free speech.
If national leaders over there think that you have gone too far, that is really saying something.
TRENDING: Radical Leftists Unleash Anti-Trump Riots Starting On March 19th
Unfortunately, the days of a free and open Internet are completely gone and they aren't coming back. Tyranny will continue to grow in the days ahead, and very dark times for humanity are coming.
It will be very interesting to see how the market moves on Tuesday. We are starting to witness a tremendous amount of volatility, and that is usually not a good sign.
Speaking of volatility, the cryptocurrency market lost a whopping 150 billion dollars in market value on Monday…
Bitcoin and other digital coins tanked on Monday, wiping some $150 billion off the cryptocurrency market.
The market capitalization or value of the cryptocurrency market was $931 billion around 6:00 p.m. ET, down from $1.08 trillion a day earlier, according to Coinmarketcap.
If you have been able to make a lot of money by riding the waves of the cryptocurrency market, good for you.
But just like the stock market, you only make money in the cryptocurrency market if you get out in time.
In the end, the cryptocurrency bubble will burst just like the stock market bubble will.
It is just a matter of time.
The "perfect storm" that began in 2020 will continue to intensify in 2021, and every part of our society will be greatly shaken by it.
Many Americans on both the left and the right are desperate for a political solution to our problems, but no political solution is going to get us out of this mess.
We are going to reap what we have sown, and this is going to be an exceedingly bitter period in our history.
Article posted with permission from Michael Snyder
Michael T. Snyder is a graduate of the University of Florida law school and he worked as an attorney in the heart of Washington D.C. for a number of years. Today, Michael is best known for his work as the publisher of The Economic Collapse Blog. Michael and his wife, Meranda, believe that a great awakening is coming and are working hard to help bring renewal to America. Michael is also the author of the book The Beginning Of The End
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Moments after the Cleveland Cavaliers' painful 108-97 NBA Finals Game 4 loss to the Golden State Warriors on Friday night, I was roasted on Twitter for calling out LeBron James, for what I felt, was his lack of taking over the game at critical stages.
As the tweets kept pouring in, I began to question if maybe I was too harsh in my words toward LeBron James or that I was tweeting out of frustration and missing something that apparently others were seeing from James during the game.
The more I thought about it, I concluded that I stand by my statement and my statement was this: "See ya next year Cleveland...as always! LeBron has been such a disappointment. No one should ever compare him to Michael Jordan...EVER!".
Make no mistake, this IS LeBron James' team and, like it or not - right or wrong, at the end of the day the failures and successes of his team land on his shoulders. That's just how the world of sports goes.
Maybe I was spoiled growing up watching Jordan win title after title and seeing him, many times, single-handedly lead his team to wins in crucial games. The most notable I recall is the 1997 Finals against the Utah Jazz.
With that series tied 2-2, Jordan played the game with flu-like symptoms and dehydration. His Chicago Bulls were trailing 77-69 in the fourth quarter of that contest when he scored seven of the Bulls' next 10 points to erase the deficit. He then drilled a three-pointer with under 30 seconds left that gave the Bulls the lead it would never relinquish. Jordan finished the game with 38 points and the Bulls eventually went on to win the title.
His head coach at the time, Phil Jackson, said after the game of Jordan, "This was a heroic effort, one to add to the collection of efforts that make up his legend."
And in my opinion, he's a legend that will never be topped.
It was Jordan's will to win that drove him and he didn't shy away from taking the crucial shot at the end of games. When the game was on the line, everyone in the building and watching on television knew who was getting the ball and he rarely was stopped.
Then there is James and my point is this:
Yes, he has averaged nearly a triple-double this entire Finals, which is very impressive, but the numbers he's putting up are not coming at critical stages of the game. He's trying to be a facilitator in those moments instead of taking over the game and putting the team on his back. The star of the team should be taking more than four shots in the fourth quarter of the biggest game of the season.
Several times in Game 4, he was out-hustled and made poor decisions with the basketball. In fact, at one juncture in the fourth quarter, James was just standing under the basket waiting for a rebound with no one around him, when Golden State came flying in and grabbed the offensive board while James never left his feet or even tried for the rebound.
Was this loss solely on the shoulders of LeBron? Absolutely not!
Tyronn Lue was badly out-coached, the Cavs as a team were out-hustled in the second half, the offense went completely stagnant with too many isolation plays, and oh, by the way... they missed 11 free throws.
Despite all of that, the Cavaliers still had a chance to win the game and tie the series... but no one stepped up.
Many say that James is the best thing that's ever happened to Cleveland and we shouldn't complain because without him the Cavs wouldn't even be in the Finals. While I agree with that to a point, the ultimate goal of any superstar athlete is to win a title and James has yet to do that in Cleveland. That was his whole purpose in coming back. I don't care that he won two titles in Miami, I'm a Cavaliers fan and want the opportunity to celebrate my favorite team winning a championship in my lifetime.
Maybe that's what is wrong with us as Cleveland fans? We've become so accustomed to being heartbroken that we are just satisfied with the opportunity to play for a title.
I, for one, am not satisfied with Cleveland teams just getting there. I'm tired of hearing all the jokes and my hometown teams being the laughing stock of the sports world year after year.
Believe me, I'm pulling for LeBron and his teammates to pull off the most improbable comeback in NBA Finals history with all the odds stacked against them. If they do, it will go down as LeBron's defining moment and Cleveland's escape from purgatory.
Reach Jim at 330-364-8434 or
jim.haynes@timesreporter.com
On Twitter: @TRJames_Haynes


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Pre-1960, Seasonal, Traditional Children's Nursery Rhymes, Christian, Flute, Piano, Piccolo. permalink.


On behalf of the parishioners of Mary Our Queen and Pastor, Rev. Darragh Griffith we welcome you to our website. We are always seeking new ways to get our message to parishioners, prospective parishioners and visitors to our beautiful parish. Please use this site to access the information you need about our parish, our ministries and to strengthen your faith. We look forward to hearing from you and answering any questions you may have. Our parish family is growing continually and our families are involved in over 30 ministries. Please carefully consider using your time and talent to support the message of Christ though our ministries.
Please be sure to introduce your self to our Pastor and visit the welcome table after mass. We invite you to become part of our parish home here at Mary Our Queen. God Bless you and your family!
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ARTISTS AT HOME
Alma-Tadema the artist
L. Alma-Tadema, Under the Roof of the Blue Ionian Weather, 1901
Lawrence Alma Tadema was born Lorenz Tadema on January 8, 1836, in the small but wealthy village of Dronrijp, Friesland (The Netherlands). Tadema attended the gymnasium of Leeuwarden, where he was first exposed to the literature and history of ancient Greece and Rome, on which he would draw for the duration of his career. At sixteen, Tadema began his training at the Academy of Art in Antwerp, becoming the pupil of Van Leys, whose style had considerable influence on the young artist. In 1863, Tadema, newly married, visited Italy for the first time. The artist's observations of the first systematic excavations at Pompeii inspired him to create paintings that depicted genre scenes set in Antiquity. These travels were followed by several years of productive work. In 1867, Tadema, weary perhaps of the Classical quotidian, turned to Classical historical subjects. (He did not, however, abandon genre scenes.) First among these was The Praetorians Summoning Claudius to the Imperial Throne After the Murder of Caligula (1867). This period marked a trend that would continue to dominate his art: the depiction of ancient Greece and Rome.[1]
Possibly acting on the advice of the art dealer Ernest Gambart, Tadema moved in 1870 to England, where his works were better appreciated and sold for greater prices,[2] though the immediate cause was probably the outbreak of the Franco-Prussian war. In London, he settled in Townshend House, Regent's Park, where he soon resumed his artistic production.[3] The popularity of Tadema's art in Britain was connected to his rendering of genre scenes from the imagined lives of Ancient Greek and Roman elites. His Victorian patrons were able to recognize themselves, albeit in Greek chitons or Roman togas, in the characters Tadema painted. His images frequently depict beautiful young people reading poetry (A Reading from Homer, 1885) and making music (Under the Roof of the Blue Ionian Weather, 1898-1901). Often, he painted young women gossiping leisurely or admiring the fabulous vistas around them (Unconscious Rivals, 1893, and Expectations, 1885). No less frequently did he depict scenes of young love (Amo Te, Ama Me, 1881). All these themes are characteristic of Victorian culture.
L. Alma-Tadema, Amo Te, Ama Me, 1881
Amo Te, Ama Me provides a good case study of the painter's work. This painting features all the elements that Tadema was known for in connection with his ancient genre scenes. The composition is dominated by a marble terrace, which seems to glow from the strikingly white light of the Mediterranean. With its parallel bands of clear, light-blue sky, and a perfectly calm sea of darker blue, the composition calls to mind Japanese prints, Aesthetic paintings, and early Impressionism. In the foreground are two beautiful young lovers. The young man seems to have sneaked in to see his beloved and offers her a bouquet of peonies, which she contemplates, as a bewitching blush of love spreads over her cheeks. But for the setting and costumes, a more Victorian scene can hardly be conceived of. The harmonious marriage of Victorian culture to the Classical setting was the secret of Tadema's success.
During the 1870s, Tadema made several trips to Italy. In 1874 he visited Rome, where he painted several works that won him a gold medal in Berlin, followed by the award of the Prussian Order of Merit in 1881.[4] In 1876, Tadema became an associate of the Royal Academy, and was elected an academician three years later.[5]
Laura Theresa, Lady Alma-Tadema, and Sir Lawrence Alma-Tadema, 1905
In 1884, when his photograph was taken by Mayall for Artists at Home, Tadema was a member of the Royal Academy and one of the most successful artists in London. The Mayall photograph is by no means the only portrait of the artist that we have.[6] Among the likenesses of Tadema are the collective portraits of prominent members of the Academy such as G. Grenville Manton's The Royal Academy Conversazione (1891) and Henry Jamyn Brooks' Private View of the Old Masters Exhibition, Royal Academy, 1888 (1889), which depict Tadema among his colleagues and acquaintances. Tadema was famous enough to merit a place in the world of caricature. One example is Carlo Pellegrini's chromolithograph, published in Vanity Fair in 1879. Photographs of Tadema by the London Stereoscopic & Photographic Company (1877) and Robert White Thrupp (1888) are the most well-known likenesses of the painter. However, one of the best photographs of the artist, in this author's opinion, is the one of 1905 by Lena Connell (later Beatrice Cundy), which shows the artist with his second wife, Laura Theresa (née Epps). The success of this photograph lies in its odd spontaneity, as though Connell had caught the couple as they were exiting their house.
In 1886, Tadema moved to his second residence in London, in Grove End Road, St John's Wood.[7] This residence, much like Townshend House, was altered considerably to Tadema's liking. Among the most important aspects of the house was the studio, designed to simulate Mediterranean light even in the winter months.[8] When he started working in this studio, Tadema's paintings changed: interiors of warm colors gave way to outside scenes dominated by marble architecture and set against the backdrop of Mediterranean seascapes.[9] In the 1880s, as in the 1870s, his art production was devoted to Roman subjects. This sustained interest in Roman Antiquity was supported by a large library and an extensive reference collection.[10]
Tadema's last decades were less productive, though he did participate and win awards in the Paris Exposition Universelle in 1889 and 1900.[11] The decoration of his new house and his interest in theatre, not to mention his declining health, reduced the time he dedicated to painting.[12] In 1890, he became a member of the Oxford University Dramatic Society. His knighthood (1899) and the Order of Merit he received in 1905 testify to his high status in Victorian society. Tadema died on June 25, 1912, in Wiesbaden, Germany, and was buried in St. Paul's Cathedral, London, on July 5. The same year, a memorial exhibition was held at the Royal Academy in his honor.[13]
Ekaterina Koposova
L. Alma-Tadema, A Reading from Homer, 1885, Philadelphia Museum of Art
[1] Georg Ebers, Lawrence Alma Tadema: His Life and Works (London: W. S. Gottsberger, 1886), 1-44.
[2] Thomas Bayer and John Page, "Commoditization and the Artist as Producer: Product Differentiation and the Domestication of Pictures," in The Development of the Art Market in England: Money as Muse, 1730–1900 (London: Pickering and Chatto, 2011), 160.
[3] Oxford Dictionary of National Biography, s.v. "Tadema, Sir Lawrence Alma-," by Rosemary Barrow, ed. H. C. G. Matthew and Brian Harrison, last modified 2011, http://www.oxforddnb.com/view/article/30396
[4] Ebers, Lawrence Alma Tadema, 67.
[5] Oxford DNB, s.v. "Tadema."
[6] National Portrait Gallery, s.v. "Lawrence Alma-Tadema," accessed November 3, 2016, http://www.npg.org.uk/collections/search/person/mp00090/sir-lawrence-alma-tadema?search=sas&sText=tadema
[7] Giles Walkley, "Decadent St John's Wood: Grove End Road," in Artists' Houses in London 1764–1914 (Aldershot, Hants, England; Brookfield, VT: Scolar Press, 1994), 127.
[8] Oxford DNB, s.v. "Tadema;" Walkley, Artists' Houses, 128-32.
[12] Rosemary Barrow, Lawrence Alma-Tadema (London: Phaidon Press, 2003), 165-69.
[13] Oxford DNB, s.v. "Tadema."
← Stephens on Alma-Tadema
Townshend House →
LAWRENCE ALMA TADEMA, R.A.
The Photographers
The Author-Editor
The Publishers
The Photogravures
T. O. BARLOW, R.A.
Stephens on Barlow
Barlow the Artist
Auburn Lodge
JOSEPH EDGAR BOEHM, R.A.
Stephens on Boehm
Boehm the artist
PHILIP HERMOGENES CALDERON, R.A.
Stephens on Calderon
Calderon the artist
16 Grove End Road
SAMUEL COUSINS, Hon. Retired R.A.
Stephens on Cousins
Cousins the artist
24 Camden Square
FRANK DICKSEE, A.R.A.
Stephens on Dicksee
Dicksee the artist
No. 2 Fitzroy Square
SIR JOHN GILBERT, R.A.
Stephens on Gilbert
Gilbert the artist
THE RIGHT HON. W. E. GLADSTONE, M.P.
Stephens on Gladstone
Gladstone the prime minister
GEORGE A. LAWSON
Stephens on Lawson
Lawson the Artist
6 Marlborough Road
SIR FREDERIC LEIGHTON, P.R.A., D.C.L., LL.D
Stephens on Leighton
Leighton the artist
Leighton House
ROBERT WALKER MACBETH, A.R.A.
Stephens on Macbeth
Macbeth the Artist
Wychcombe Studios
JOHN MACWHIRTER, A.R.A.
Stephens on MacWhirter
MacWhirter the artist
No. 1 Abbey Road
WILLIAM CALDER MARSHALL, R.A., H.R.S.A.
Stephens on Marshall
Marshall the artist
115 Ebury Street
JOHN EVERETT MILLAIS, R.A., D.C.L.
Stephens on Millais
Millais the artist
2 Palace Gate
JOHN PETTIE, R.A.
Stephens on Pettie
Pettie the artist
The Lothians
EDWARD JOHN POYNTER, R.A.
Stephens on Poynter
Poynter the artist
VALENTINE CAMERON PRINSEP, A.R.A.
Stephens on Prinsep
Prinsep the artist
1 Holland Park Road
RICHARD REDGRAVE, Hon. Retired R.A.
Stephens on Redgrave
Redgrave the Artist
18 Hyde Park Gate South
BRITON RIVIERE, R.A., M.A.
Stephens on Riviere
Riviere the artist
Flaxley
MARCUS STONE, A.R.A.
Stephens on Stone
Stone the artist
8 Melbury Road
GEORGE ADOLPHUS STOREY, A.R.A.
Stephens on Storey
Storey the artist
19 St. John's Wood Road
Stephens on Alma-Tadema
Townshend House
W. H. THORNYCROFT, A.R.A.
Stephens on Thornycroft
Thornycroft the artist
Moreton House
GEORGE FREDERICK WATTS, R.A., LL.D.
Stephens on Watts
Watts the artist
New Little Holland House
THOMAS WEBSTER, Hon. Retired R.A.
Stephens on Webster
Webster the artist
MR. WILLIAM FREDERICK YEAMES, R.A.
Stephens on Yeames
Yeames the artist
Acomb Lodge
Victorian Artists at Home


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Results of AbbVie's Rinvoq in atopic dermatitis position it to rival Regeneron's Dupixent
Rinvoq reportedly met all secondary endpoints in the study as well, especially in terms of reducing itch associated with atopic dermatitis. Credit: Shutterstock.
AbbVie has released the topline results of its Rinvoq (upadacitinib) second pivotal Phase III trial, Measure Up 2, in moderate to severe atopic dermatitis, which tested the Janus kinase (JAK) inhibitor monotherapy against placebo in 810 adolescents and adults at doses of 15mg and 30mg. Similar to the replicate Measure Up 1 study, which had topline results announced in June 2020, both co-primary endpoints of at least a 75% improvement in the Eczema Area Severity Index (EASI 75) from baseline and a validated Investigator's Global Assessment for Atopic Dermatitis (vIGA-AD) score of 0/1 (clear or almost clear) at Week 16 were met. Among patients receiving the 15mg and 30mg doses of Rinvoq, 60% and 73%, respectively, achieved EASI 75, whereas only 13% receiving placebo achieved EASI 75. Likewise, 39% of the 15mg group and 52% of the 30mg group met the vIGA-AD threshold, compared to only 5% of the placebo group. Despite such promising efficacy, Rinvoq may struggle to rival Regeneron's Dupixent (dupilumab), the current gold standard for the treatment of moderate to severe atopic dermatitis, based on the JAK-1 inhibitor's class-wide boxed warnings for serious infection, malignancy, and thrombosis.
Rinvoq reportedly met all secondary endpoints in the study as well, especially in terms of reducing itch associated with atopic dermatitis. The 15mg and 30mg groups achieved 42% and 60% reductions, respectively, in Worst Pruritus Numerical Rating Scale of four or greater from baseline, compared to 9% in the placebo group. Other notable secondary endpoints that were met include a percentage of patients achieving EASI 75, EASI 90, and EASI 100. Rinvoq had a safety profile consistent with that seen in Measure Up 1, and no new safety risks were observed compared to the safety profile seen in rheumatoid arthritis patients and psoriatic arthritis patients treated with Rinvoq. Fewer serious adverse events were seen in the two treatment groups than in the placebo group, and no venous thromboembolic events were observed in participants treated with Rinvoq.
However, one of the most common AEs was acne, seen in 12.7% and 14.5% of patients receiving 15mg and 30mg Rinvoq, respectively, compared to just 2.2% in the placebo group. Such a significant number of participants developing acne may discourage patients from taking the treatment if it were to be approved, despite being orally administered, unlike Dupixent's subcutaneous route of administration. Unlike Rinvoq's boxed warnings, Dupixent has been on the atopic dermatitis market for three years and is well known for its strong safety profile. As such, GlobalData expects the 2027 sales of Rinvoq in the seven major markets (US, France, Germany, Italy, Spain, UK, and Japan) to reach $1.1B and the 2027 sales of Dupixent to reach $5.3B for atopic dermatitis alone.
Cellular Technology Limited
Standardized Tools for Cellular Immune Assays
AbbVie's Combination Therapy: ABT-450, ABT-333, and ABT-267 (Hepatitis C Virus) – Forecast and Market Analysis to 2022


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Hamilton sure he can go quicker still after Monza practice
By Luke SmithSep 4, 2015, 1:00 PM EDT
Lewis Hamilton sent out an ominous statement of intent to his rivals by saying that he could go faster still after topping both practice sessions at Monza on Friday.
Running with an upgraded power unit for this weekend, Hamilton and Mercedes teammate Nico Rosberg stormed to a one-two finish in FP1 and FP2.
Sebastian Vettel of Ferrari finished as the best of the rest in both sessions, but the gaps of 1.588 seconds and 0.759 seconds to Hamilton in FP1 and FP2 respectively make Mercedes' advantage clear to see.
However, Hamilton still feels that there is more to come from Mercedes at Monza across the remainder of the weekend, saying after practice how he felt that there was extra pace in the car.
"Today was a good day definitely a testing day in terms of our programme," Hamilton said. "I had a bit of a break in the second session but it was just so the team could check a few spikes in the data and everything was okay in the end.
"I didn't particularly hook up the first two sectors this afternoon, they were definitely better in the morning. So I'm sure there's some pace to find and I'll be looking through the data tonight to find it.
"There's nothing major, just very small tweaks here and there which might give that bit extra. The car is feeling good and the team are doing a great job but its still very intense out there."
Regardless of his advantage, Hamilton said that he is still wary of the threat from behind that could come from Ferrari across the remainder of the weekend and the rest of the season.
"We're working as hard as we can to keep improving and the challenge is always there no matter how fast you are," Hamilton said.
"Now we need to keep it together through the weekend. It should be close with Nico as always so I'm looking forward to a battle."
Qualifying for the Italian Grand Prix is live on NBCSN and Live Extra from 8am ET on Saturday.


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A memorial to a truly great aviator, Bob Odegaard
I've only met Bob Odegaard one time, but that's all it took to know this was one of the aviation family's most accomplished aviators. We all should strive to be the kind of pilot he was, a humble but focused man who never met another pilot who was not his instant friend. And on Friday, September 7, 2012, in a crash as he practiced for an air show in Valley City, ND, the life of this wonderful pilot and generous human being was cut short at the young age of 66.
I never did any business with Bob, nor spent more than three days with him and his family. I know nothing of his personal life other than what has appeared in the Fargo, ND area press, which describes him as a generous man with strong convictions who helped numerous organizations build a better community in his hometown of Kindred, ND. Of course, his talents for building and flying airplanes are legend. So my opinion of him is based solely on how he and his family treated me for those glorious three days in 2010 when he invited me along to ride with him and son Casey as they flew the family DC-3/C-47 - Duggy, The Smile in the Sky - down to the "Last Time" DC-3 reunion and then on into EAA Airventure OShkosh.
First, to understand what this flight meant to me, you need to get inside my head and understand what Duggy means to me:
I am of the opinion that our airplanes are in many ways like living things, they have souls, and they know their roles in our aviation world. Of all the makes/models flying, none have quite as many stories to tell as the DC-3/C-47, and of those, Duggy might be the leader of the pack. This plane has a personality and a soul that goes far beyond simply being a collection of parts bolted together to convert dead dinosaurs into altitude. If you are a true aviator like I am, you feel it when you climb aboard this bright yellow plane. You feel all his admirers, the passengers and the soldiers that have been there before you. There is a sense that this particular airplane is happy (see the SMILE?) to again be lofting skyward to fly over the clouds in search of more children eager to have their little fires lit about flying. But behind Duggy was one gentle, determined man, his owner, Bob Odegaard. Along with a team of family and friends, Team Odegaard kept Duggy's mission alive, to start each day's air show at Oshkosh by deploying skydivers, or just sitting on the ramp welcoming endless streams of kids to come inside...and dream.
When I first read about the Last Time reunion planned for Rock Falls, IL, I decided to email Bob and ask him point blank that as a journalist, could I somehow hook up with him and Duggy to fly into that event. On the phone call that resulted, when Bob found out I was a pilot, he did not hesitate five seconds to invite me along. "We'll have some empty seats I imagine," Bob said, "and if you're that much of a fan of Duggy, I'm sure he'll be happy to have you on board. Just get yourself to Fargo and we'll go have some fun."
After flying into Fargo, I was soon out at the Odegaard's hangar complex in Kindred. Upon arrival, I saw Duggy's right engine in pieces, with both Bob and Casey on ladders wrenching away. We had an early AM departure planned, but a spark plug had broke off inside a jug on the right, and with a thunderstorm approaching, you would think the pressure was building to get those bright yellow cowlings back on and get Duggy pointed towards Rock Falls and eventually Oshkosh. You would THINK that with 500,000 people eager to enjoy their annual summer visit with The Smile in the Sky, the Odegaards would have been sweating bullets.
In the next few hours – as the sky darkened and the infamous 787-sized NoDak mosquitoes started doing touch-and-goes on any skin not covered with armor – Bob and Casey calmly replaced the jug, without one drop of sweat or any foul language. I stood in awe as they completed the complicated dance of tearing off and replacing the jug on an old radial engine. Through all of this, Bob displayed a demeanor that was super cool. Lots of smiles, plenty of joking and laughter by all. I was impressed.
That afternoon, a group of five or so more people along for this flight showed up, and we finished the night in Odegaard's hangar, you guessed it, hangar flying. We ate microwaved pizza and listened intently as this man told plenty of crazy stories, each more unbelievable than the next. But when you are surrounded by so many trophies, plaques, awards and of course, a gigantic stable of exquisite warbirds – including the Super Corsair – and uncountable radial engines, parts, memorabilia and other artifacts from a flying life well lived, you just know this man has done all the things he speaks of in these hangar flying tales. It was two of the most cherished hours of my flying career, to be there, listening to that man, knowing that the next day I get to climb about Duggy and fly off to the next adventure.
And late that night, we finally arrived out at the Odegaard ranch, where I was treated like family. He and his wife was warm and friendly, and I commented that they really didn't have to be hosts, just aim me at a bed and I'd be good. But Bob put his hand on my shoulder and calmly said "you're a transient pilot, and anyone that visits Kindred is welcome here any time." This is an aviator that understands what the phrase "pilots helping pilots" really means, and lives by a set of unwritten aviator's rules we all need to aspire to follow.
The next two days were aviation bliss...times 100. Every second of time inside that storied DC-3/C-47 – with a stereo symphony of radial engine noise reverberating through the cabin – was so wonderful, so important and so priceless, it is hard to put into words. Along the way, Casey did most of the flying, and Bob spent lots of time in back, chatting up his pax. As we droned along over what I suspect was either corn or soybeans stretching to the horizon, Bob got out his classic, original Fender Mustang electric guitar, plugged in to a small amplifier, and sat on Duggy's floor. He picked out a very nice collection of riffs that were one part Elvis and two parts Buddy Holly, and right there, in that scene, I think I might have actually got misty-eyed. It was one of those aviation moments so rare and so intense, you know you'll never live it again and surely will never forget even one tiny detail.
We made the Rock Falls event, and the next day, flew the "Warbird Approach" into Oshkosh. That "C-47" on Duggy's data plate made that approach official. Along the way, Bob let me stick my camera - with flash - in his face all the time, blasting away without so much as a stern look. The dude just smiled all the time, it's a little freaky. When we finally deplaned just shy of show center, I tried thanking Bob, but words could not be found to express the unbridled joy my aviator's soul was feeling inside. I had just flown into the world's greatest aviation celebration in the happiest plane in the sky.
Think about that last sentence for a minute.
In the slight confusion over getting Duggy parked and removing our bags, Bob Odegaard jumped on a golf cart and was gone. I tried for the next two days at the show to catch back up to him and try to thank him for providing me with the flight of a lifetime. But I never ran into him again.
So tonight, I write this at 1:24AM, not able to sleep, missing Bob terribly. What does it say about a man's character when you can hang out for only three days and feel this sort of sadness when he dies? It says this is one huge loss, not just for me, but for North Dakota, for the entire aviation family, and for Duggy.
I know that beautiful big yellow guy is one tough bird, but I can assure you he is not smiling as wide right now. Because I know he and Bob had a mutual respect for each other that only an airplane and its owner/pilot can share. I hope Duggy's mission lives on after such a tremendous loss, because we all know Bob would want it no other way.
Godspeed Bob, now go teach Doolittle and Lindy a thing or two about flying airplanes. Say hello to Papa Louie up there. You were a good friend I will never get to know.
UPDATE: The funeral for Bob will be Wednesday, September 12th in Kindred, with a remembrance for at the Fargo Air Museum at 5pm on Wednesday the 12th. All the info is available here.
UPDATE: I have been asked to post more photos from this wonderful flight. So here is an embed of the Picasa gallery (it is flash so if you are on a mobile, click here to view):


Rayman Origins is rated 4.7 out of 5 by 3.
A Massive World: Rayman Origins includes over 60 levels of platforming gameplay.
Epic Boss Fights: A giant pink monster with hundreds of eyes... A possessed, mountainous golem... and more!
Variety of Gameplay: Rayman Origins is a platformer at its core but also features many elements of action, adventure, shooter, and beat-'em-up gameplay.
Rebirth of a Platforming Legend: It's been 15 years since the first launch of Rayman. Rayman Origins brings back many of the classic characters, revived in their original form, as well as a whole new world of characters and environments.


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Q: What's command to change the commit in the HEAD file without changing any other files? What's command to change the commit in the ".git\HEAD" file without changing any other files?
I needed files from one branch, but the Head points to another

A: If you just want to check the outcome of a merge, you could just do the merge. If it is successful you can undo it with git reset HEAD^1. If it fails with conflicts you can go back with git merge --abort. Another possibility is doing a merge without commit as @evolutionxbox suggested (git merge <branch_name> --no-commit).

redpajama_set_name: RedPajamaStackExchange


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Solomon is 2017 National Academy of Sciences Medalist
Helen Hill for EAPS News
Susan Solomon, the Lee and Geraldine Martin Professor of Environmental Studies at the Massachusetts Institute of Technology, will receive the 2017 National Academy of Sciences, Arthur L. Day Prize and Lectureship.
Solomon has been a leader in the fields of atmospheric chemistry and climate change for three decades. In 1986, Solomon proposed that novel chemistry was taking place and then used optical techniques to demonstrate that chlorine and bromine released by chlorofluorocarbon (CFC) gases were responsible for the ozone "hole" over Antarctica, which had been discovered just a year earlier. This groundbreaking work has now become standard text in any description of stratospheric ozone processes. Her findings contributed to the establishment of the Montreal Protocol to reduce emissions of CFC gases beginning in 1987. Thirty years later, Solomon used observations and model calculations to identify the first signs of the recovery of the Antarctic ozone layer, an indication of the progress and effectiveness of the Montreal Protocol.
In addition to her personal scientific contributions, Solomon has served as a co-chair of the Intergovernmental Panel on Climate Change Working Group I, leading an effort of hundreds of authors and reviewers for the 2007 IPCC international climate assessment report. Throughout her career, she has also worked to communicate the science of climate change to the public and to policymakers.
The Arthur L. Day Prize and Lectureship is awarded to a scientist making lasting contributions to the study of the physics of the Earth and whose lectures will provide solid, timely, and useful additions to the knowledge and literature in the field. The recipient is awarded a $50,000 prize and funds to present a series of Day Lectures, supported by the Arthur L. Day Bequest.
The winners will be honored in a ceremony on Sunday, April 30, during the National Academy of Sciences' 154th annual meeting.
The National Academy of Sciences is a private, nonprofit institution that was established under a congressional charter signed by President Abraham Lincoln in 1863. It recognizes achievement in science by election to membership, and — with the National Academy of Engineering and the National Academy of Medicine — provides science, engineering, and health policy advice to the federal government and other organizations.
Story image: Susan Solomon - Photo credit: Dominick Reuter
Susan Solomon
Explained: Greenhouse gases MIT News
Short-Lived Greenhouse Gases Cause Centuries of Sea-Level Rise MIT News
Scientists Observe First Signs of Healing in the Antarctic Ozone Layer MIT News
New Year Awards News (First signs of healing in the Antarctic Ozone Layer, a top pick for the 2016 top stories lists at Science News and Discover Magazine) EAPS News


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La mofeta dels Andes (Conepatus chinga) és una espècie de mofeta de Sud-amèrica. Viu a l'Argentina, Bolívia, el Brasil, Xile, el Perú i l'Uruguai.

Referències

Mamífers de l'Uruguai
Conepatus

redpajama_set_name: RedPajamaWikipedia


The RTS Wargame SuperPower II is an incredible feat of online gaming strategy and out of all the games that we have played this is definitely one that players could stand to use a strategy guide. The SuperPower II Strategy guide helps players in their quest to achieving peace in the world or conquering it. When playing Super Power II and not using a Strategy Guide, players might find it difficult to complete their objectives against AI opponents. In trying to reach the objectives for the chosen end game, players may find some of the strategies in the Super Power II guide helpful. The most helpful are those tactics that deal with diplomatic measures.
Super Power II was a highly complex game and because of this, not having a Super Power II strategy guide could work against the player. One thing that the Super Power II guide can assist in is the reversal of Autarky in games which go over 160 hours. This is a necessary fix that can only be found in the Super Power II Strategy Guide on page 372.
The Super Power II Casino Game Guide is also a good way to come up with strategies for the ever popular Super Power II Casino Game.
The best poker news is generally available on a daily basis. Casual players do not tend to need daily updates on poker news, but professional players that make their living from the game often check the news hourly. Poker tournament news is especially important to those professional players.
It's time to put away your childish card games and step up to a real game. Learn how to play poker once and for all and finally get into the games that you have always wanted to be a part of. Poker has a culture of its own and it accepts anyone into it as long as they know how to play poker. If you don't know how to play poker then you'll be booted right out of any poker room in the world. Learn how to play poker before you sit down at your local poker club or casino and discover the real poker star that is in you read more here.
Copyright 2007-2013 superpower2game.com . All rights reserved.


I'm very passionate on my chosen career .
I'm Charina,I am energetic and cheerful a self oriented and enthusiastic person. A fast learner in work I can able to do my assigned task.i am honest,industrious and responsible.i am hard working ,playful, cheerful and God fearing.i have experienced working with the British family with 2kids in Singapore,2 years in hk with Chinese family with 1kid.2years with Chinese family with 1 Son.now currently working with korean family with 3 kids 5,3,newborn .I believe that this span of years that I've been working in different cultures,values and how to interact and communicate to other people that I've met.I'be learned to execute all the different task with precision and I pay attention in all the details of the things that I need to do in a timely manner.I am eager to take a new challenge to provide my service that I can offer you. Thank you!


Sunrise Hotel is a 3-star complex which offers five type of rooms, breakfast, a stunning view from the balconies and an incredible garden decorated with perfumed flowers such as roses and sweet mock-orange.
Immediately as we arrive, we were so impressed by the garden which looked stunningly beautiful. Our hosts welcomed us with a cup of a local drink. I noticed that the hotel is very clean, tidy and cared.
Te prices start from 42€ for the single room and 75€ for the triple room. Prices may vary in high season, Also, the rooms with sea view are a little bit more expensive.
I had a such a nice surprise to see that I have some meals to chose. It is not a complicated breakfast, but you have salad, feta, butter, olives, omelet, sausages, cheese and some cold meats such as ham and salami. As for sweets, you have cookies, marmalade and cake. Every morning you have good coffee and delicious orange juice.
In may 2017, the rooms in the reception building are completely renovated. I visited those rooms and all is new: tiles, faience, furniture, sanitary ware, mirrors. Even the mattresses were in foil.
The hotel has a rate of 9.2 on Booking and it's 100% booked in high season, beeing one of the tourist's favorite places in Ammouliani. You can check it here and here.


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The Coming of the Railways Walk
We start at London's first railway terminus and railway line, then it's on to the world's first tunnel to be constructed under a river. We see some of the tunnel as we disappear down into it to get an Overground train through it. This takes us to the world's oldest railway aqueduct, which is part of London's second oldest railway line, still in use today. You see charming 1840's railwaymen's cottages nearby, hear why the railway was important in Victorian philanthropy. At two of the modern stations we travel through we see how some of the oldest stations have been used as foundations for modern ones. We also see a great Victorian station facade before getting a tube to an underground station, still looking pretty much as it did 150 years ago, when it was on the oldest underground line in the world.
This walk is obviously aimed at railway enthusiasts but it's also a good tour for people who would like to be shown around lots of sights without doing much actual walking. And it's also a good walk in mid-winter, because you're not out in the elements as much as on other walks. The tour includes three train/tube journeys. Oyster or travelcard required.
Start Bermondsey Underground station
Finish Farringdon Underground Station
Shorter walk alternative – Start Rotherhithe Overground station


← Broward Health Board Meeting – Part II Clueless!
El Sanadi, who became Florida's Broward Health's new CEO after he and a handful of Board members orchestrated the ouster of the previous CEO, is apparently making a lot of changes behind closed doors, that should us all and which don't seem good for Broward's public Hospital.
After the herculean effort to certify Broward Health as a teaching hospital system through a decades long and successful (although sometimes bumpy) collaboration with NOVA Southeastern (NSE), El Sanadi and the Chair of the Board are scuttling the system's relationship with Broward's NOVA Southeastern and replacing it with Miami's FIU. According to one report, El Sanadi has given instructions not to hire any more Fellowship physicians or interns from NSE. Apparently, El Sanadi has also made Dr. Kumar (a critical care physician who will be featured in a future article you won't want to miss) the Medical Director in charge of the FIU program at Broward Health. This policy change has never been presented to the Board publicly nor has Kumar's new directorship contract.
In addition to the NSE change, El Sanadi with the Chair and another Board Member are believed to be pushing for a Request for Proposal (RFP) for security services for their Republican friend ex-sheriff Lamberti. This policy change also has never been presented to the Board publicly.
It is believed that El Sanadi with the Chair and a different Board Member are asking how they can get the Investment & Pension Committee to send out a new Request for Proposal (RFP) to change the professional finance adviser to Broward Health in favor of a "friend" of the Board member. It should be noted that this is for an investment and pension portfolio of more than 800 million dollars. This policy change also has never been presented to the Board publicly.
And if that's not enough, El Sanadi and the Chair are seemingly working to establish a Kidney transplant center at Broward Health to attract patients from outside of Broward. Not only is this capability duplicative in the area, but, at a cost of millions of dollars, it has very limited use for the public Broward Health purports to serve. You guessed it. This policy change also has never been presented to the Board publicly.
One cannot help but wonder how long the other Board Members are going to allow this race to return to the dark days of Broward Health's past, where Broward Health was little more than a cash register for insider dealing, to continue. But, I guess the Board needs to be informed first, but shhhh… it's a secret.
This entry was posted in Corporate Management, Physician Contracts and tagged Al Lamberti, Broward Health, Broward Healthcare, Darrell Wright, David DiPietro, David Neiland, FIU, Investment, Nabil El Sanadi, Nova Southeastern University, NSE, Pension, RFP, Sunil Kumar, Teaching Hospital. Bookmark the permalink.


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theBABAorchestra
(2019 - Thirsty Owl Records - USA)
https://thebabaorchestra.bandcamp.com/album/marigold
With an unusually sparse and singular piano, followed by similar fashioned flutes, the intro to 'Marigold' begins what is surely a four suite cargo load of fellowship between orchestral complexity, fraught with independence, daring peculiarity, high emotion, wistful inventive, and fully engaged musicianship. Crawling with RIO elements, especially Univers Zero and their roots of classical composers such as Bartok, Dvorak, and Stravinsky, Baba displays many of the same influences from her debut 'Another Ride on the Elephant Slide' (2017), which at this point, has become a status and style of her own.
Using an adept 17 piece outfit, Lauren Elizabeth Baba conducts and leads her own compositions with incredible results. This experimental big band treads where ensembles like Flat Earth Society (Belgium), Carla Bley, and Hermeto Pascoal challenge, with a list of more too long to list. 'Marigold' is inspired by Baba's family immigration from Syria and Greece. The four compositions, are actually a "loop with no beginning or end" representing all the characteristics of life, "understanding that the past, present, and future are simultaneous experiences".
This musician, composer, conductor, bandleader, has an already fine resume as a guest conductor, award winner, guest violinist/violist (on various projects including her Seattle friend and creative big band composer-trumpet player Samantha Boshnack's release ' Seismic Belt', and the illusive progressive alt band Fell Runner's 'Talking'). With her second release, this continual four part composition of just under 42 minutes, does all the things that made her debut so fantastic, and stretches out even more. The avant-garde aspects give Henry Cow lovers a rush, the jazz fusion is out of this world, and the rock impact keeps the floor vibrating, along with a the wild roller coaster ride which is a thrill you will not believe. The outcome is overflowing and with very few moments of respite, the listener receives what almost feels like a succession of encores. In the same time span you are being lulled into a tepid labyrinth of mystery, one is also suspended in the canopy of brilliant fifth dimension. UNCONDITIONAL RECOMMENDATION.
©Reviewed by Lee Henderson 11 - 9 - 2019


Sarah Milne is a Lecturer in the History and Theory of Architecture at Westminster. She is currently leading an M.Arch. seminar group centred on Cullen. Sarah is also a historian at the Survey of London, the Bartlett, UCL.


Enigma Black is a heart warming novel mix of romance, sci-fic action thriller and political drama, where Celaine Stevens comes out as a very strong main character.
The book slowly takes readers through phases of Celaine's life where she has to go through so much when she looses her loved ones due to terrorist attacks. Character of Celaine was so well portrayed by the author that it made me feel she was someone i knew well. The decisions taken by Celaine at different stages of life and her recovery from grief to a super hero brought burst of emotions in me.
Although the book has many other amazing characters evil and good like Blake, Chase, Lucy and man in black, Celaine was the most appealing. It was heart whelming to see a women come up so strong against the evil of terrorism and fight back, in spite of being broken down by the wounds of past of loosing her family.
The book has realistic dialog between characters and action packed scenes which will let the imagination of readers grow wild and free. The novel has a very strong story line ,with the base of today's Worlds biggest evil 'terrorism'. This book gives all women inspiration to come up strong in any situation and be superheros of their life.
Highly recommended to the wonderful specie 'women' and to all those looking for an incredible read!!
This entry was posted in BOOK REVIEWS, fantasy, Romance, Sci-Fi. Bookmark the permalink.


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The Daughter
Available in: 720p.BluRay 1080p.BluRay
6.6 10 5173
720p.BluRay 1080p.BluRay
Set in the last days of a dying logging town, Christian (Schneider) returns to his family home for his father Henry's (Rush) wedding. Reconnecting with his childhood friend Oliver (Leslie) and Oliver's family, wife Charlotte (Otto) and daughter Hedvig (Young), he unearths a long-buried secret. As he tries to right the wrongs of the past, his actions threaten to shatter the lives of those he left behind years before.
Simon Stone
Nicholas Hope as Peterson
Kate Box as Julieanne
Ewen Leslie as Oliver
Paul Schneider as Christian
720p.BLU 1080p.BLU
P/S 0 / 1
Reviewed by SnoopyStyle 6 / 10
powerful moments
Hedvig Finch (Odessa Young) is the daughter of Charlotte (Miranda Otto) and Oliver (Ewen Leslie). They run into his old friend Christian (Paul Schneider) and reconnects with him. Christian has returned to town for his wealthy father Henry (Geoffrey Rush) who is marrying a much younger woman. Hedvig has boyfriend Adam (Wilson Moore). Walter (Sam Neill) is Oliver's father. A secret is revealed and Hedvig's world falls apart.
This is an adaptation of the 19th century play The Wild Duck. The storytelling is bit muddled at first. I don't know much about filmmaker Simon Stone but he seems to be a newcomer to directing cinema. It shows in the scattered nature of the plot flow. What he seems well adapted to is drawing out good performances from his actors. There is the big climatic scene with Hedvig and Oliver. Throughout, the acting is top shelf. I would reorganize the sequencing of events by doing the reveal earlier and Adam's departure later. It's all about Hedvig and how her life falls apart. Adam leaving should be the last straw. There are powerful moments in this movie. A more experienced filmmaker would be able to construct a more compelling flow of events.
Reviewed by clanciai 8 / 10
Ibsen in darkest Australia
I knew nothing about this film when I started watching it, but gradually some details of it gave me some sense of familiarity. I recognized it but could not place it. These details turned up more and more, and suddenly it dawned upon me: This is Ibsen! Yes, he had been transformed and dressed up (or down) into Australian settings out in the wilderness, and some excellent players made justice to the leading characters, mainly Sam Neill and Geoffrey Rush. Although it was all perfectly Australian and in modern times, still Ibsen shone mercilessly through, with the same gradually increasing and towering destiny of doom leaving no one out of the devastation. Was it a successful transition? Yes and no. What was missing was the clarity of Ibsen as here it was too easy to confuse some characters with each other, and as it was a theatre play, transformed into a film almost in the dark of the jungle the drama was partly lost in almost dogma scenery muddled up in darkness. It was not entirely successful, while the drama will be as shocking and upsetting as the original in whatever settings it will be presented.
Reviewed by maurice_yacowar 8 / 10
optimistic update of Ibsen's The Wild Duck
Simon Stone's The Daughter is "inspired" by Ibsen's The Wild Duck but it's radically different. Stone gives the Danish Nietzschean tragedy a contemporary Australian setting with an upbeat spiritual ending.
The basic plot holds. A wealthy industrialist's son Christian returns from self-exile for his father Henry's marriage to his much younger housekeeper. Christian's mother killed herself over Henry's affair with an earlier Housekeeper, Charlotte. Now Christian learns that Charlotte married his best friend Oliver who thinks the daughter Hedvig she had by Henry is his. Whether out of bitter despair over his own romantic loss or out of wrong-headed idealism, Christian reveals the long buried secret. His friend is revulsed by the wife and daughter he has so profoundly loved and rejects them. Hedvig shoots herself.
Stone makes significant changes. His Hedvig frees the duck that Henry had shot down and Hedvig and her grandfather Walter nurtured. Ibsen's Hedvig agrees to her father's demand she put the duck out of its misery, then shoots herself instead. Stone's Hedvig is herself a creature of nature. Her science fair project is a study of amino acids, in and beyond the human body. Her eagerness for sex confirms her natural appetite, as she invites both her young boyfriend and Christian.
Her sexual initiation in the forest is enigmatic. The boy had earlier postponed this First Time until her birthday. In the event, he -- as university registrars put it -- withdraws in good standing and runs off. Perhaps he felt guilty about not having told her his family was moving away. Perhaps her virginity -- she hurts, despite her claim to experience -- and the unaccustomed condom embarrassed him with a premature ejaculation. In any case, the scene presents him as a modern, sensitive young man, The New Man, in contrast to the bullish self indulgence of Henry and his generation.
By renaming Ibsen's Gregers Christian, Stone implies another contrast, between Henry's pagan self indulgence and the new man of conscience. Christian urges Charlotte to reveal her secret to her husband: "The truth can't hurt you." But this son can't escape his father's hold, as his retreat to drink and drug reveals. Embittered that his woman has dumped him, Christian may not be as noble as he thinks when he shatters his old friend Oliver's happy family. The destructive power of the father is visited upon the son, for all his moral pretensions.
Henry has ruined the family. He let his friend and partner Walter go to jail for their joint scheme. Giving him a pension and helping Oliver buy his modest house is scant compensation. But his destruction of the family is incomplete until his possibly well- meaning son shares his destructive truth. For that even Henry's promise of a trust fund for Hedvig cannot compensate.
The film's last shot poses an ambiguity beyond the play's solid suggestion that Hedvig killed herself. The medic has said she has a chance. The last shot shows her in radiant close-up, eyes closed. Does she recover? Does she die? We're left to our own conclusion. Modern audiences will leap to the hope of a conventional happy ending.
But Stone directs us to a more complex conclusion. The radiance makes her appear angelic, confirmed by the religious chorale. The implication is that she dies but in a transcendent way. She returns to her quintessential unity with wild ducks, animal appetites and amino acids. Her wounding has shaken her effective father out of his mad self denial, so he resumes his love for her and his wife. And she is finally freed from her brute father Henry's clutch. In this delicate balance Stone respects Ibsen's tragic vision but allows for the alternative encouragement, the view that we don't live in an uncaring brutal universe but in a world of material and spiritual interconnection.


A federal district judge has extended a deadline for Volkswagen to submit a plan to recall 600,000 diesel-powered vehicles with emissions cheat software, reports Bloomberg.
U.S. District Judge Charles Breyer in San Francisco on March 24 set a deadline of April 21 for the company to come up with a detailed plan. Breyer had previously given the company the March 24 deadline, and said "substantial progress" has been made in granting the extenton.
The cost of buying back the affected vehicles could cost $9.4 billion, according to a Bloomberg Intelligence analyst. A Kelley Blue Book analyst put the amount at $7.3 million.
"Volkswagen can't move past its diesel challenge until a solution is confirmed for all cars that don't meet current standard," said Karl Brauer, senior analyst at Kelley Blue Book. "While any fix for these vehicles will be complex and costly, every delay extends the timeframe to get past this scandal and on to rebuilding the brand."


Wellington is a fantastic community in the heart of beautiful Prince Edward County. Set in the heart of wine region, the area benefits from a relaxing and slow pace, a fabulous escape from urban living.
The area boasts renowned beaches and boardwalks as well as walking trails, golf course, parks and fantastic community centre to keep you active all year round.
The area is rich in history with the first settlement in the area dating back to the eighteenth century.
There is a museum, the Drake hotel recently opened in the area and baseball, tennis and hockey are popular sports.
Come and become part of the great community that is Wellington!
The Sandbanks Beach and provincial park is the most famous beach in the region, and with good reason, while the Wellington heritage museum showcases the history especially on the canning industry. The Drake hotel is a boutique hotelier, and the local community center, harbor, and trails for hiking and riding as well as public parks will keep you active and fit all year round.
There is also a farmer's market for fresh produce. For sports, there is a tennis court, hockey pitches baseball courts, running track, dual purpose field and a golf course.
There are numerous wineries in the region and restaurants to enjoy local delicacies.
One of the first of the first settlers, Daniel Reynolds, came into the area came in the 18th Century and was nicknamed Old Smoke leading to the community's first name which was Smoke Ville.
With the establishment of the post office, the name of the community was changed to Wellington after the Duke of Wellington.


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Artios Strengthens Management Team with the Appointment of Dr Simon Boulton as Vice President Science Strategy
Artios Pharma Ltd
("Artios" or "the Company")
Strengthened Management Team with the Appointment of Dr Simon Boulton as Vice President Science Strategy
Cambridge, UK, 2 November 2016. Artios Pharma Ltd., a newly launched private company focussed on developing novel cancer treatments targeting the DNA Damage Response (DDR), today announces it has strengthened its management team with the appointment of Dr Simon Boulton as Vice President (VP) Science Strategy.
Simon is an award-winning British scientist at the Francis Crick Institute in London who has made important contributions over the past 20 years to the understanding of DNA repair and the treatment of cancer resulting from DNA damage. As a result of his ground-breaking work, Simon has received a number of prestigious accolades, notably the EMBO Gold Medal and the Paul Marks Prize for Cancer Research. In addition to his current role at the Francis Crick Institute, Simon is an honorary Professor at University College London, an elected member of EMBO and a Fellow of the Academy of Medical Sciences. He has given numerous prize lectures, including the Royal Society Francis Crick Prize lecture and the Mendel Lecture. Simon established the DNA Damage Response group at Cancer Research UK's Clare Hall laboratory, which became part of the Francis Crick Institute in April 2015.
As VP Science Strategy at Artios, Simon will play an important role in assisting the business development team in the identification and evaluation of new pipeline opportunities from the global academic and industrial DDR network. Simon will also provide scientific leadership and support to the ongoing development of the two lead DDR programmes that Artios has in-licensed from Cancer Research Technology (CRT), the development and commercialisation arm of CRUK, one of which originated from Simon's research group while based at Clare Hall laboratory.
Simon will join the newly formed leadership team at Artios Pharma, alongside his current and principal position as Senior Group Leader at the newly formed Francis Crick Institute, London. He will work together with Dr Niall Martin, Chief Executive Officer; Dr Nick Staples, Chief Business Officer; Andrew Muncey, Chief Financial Officer; Dr Peter Harris, Chief Medical Officer and Dr Harry Finch, Medicinal Chemist at Artios. This management team combines a strong track record of product discovery and development in the DDR field together with considerable transactional and operational experience in rapidly growing companies.
Commenting on today's announcement, Dr Niall Martin, Chief Executive Officer of Artios Pharma, said: "Following our recent successful £25 million fundraise and subsequent launch of Artios as a new company focussed on developing new DDR targeted cancer therapies, we are delighted to welcome Dr Simon Boulton to our management team. Simon brings with him considerable DDR experience and a wealth of contacts and knowledge in the field, all of which will be invaluable as we continue to build a pipeline of first-in-class DDR programmes and establish Artios as a leading player in the DDR field."
Simon Boulton, VP Science Strategy at Artios Pharma, said: "I have dedicated my career to the DNA repair field and believe there are many new and exciting opportunities to exploit our knowledge of DNA repair pathways to develop novel inhibitors to tackle cancers. I am delighted to have the opportunity to work with Artios, a company specialising in DNA Damage Response and passionate about developing novel treatments for cancer. I look forward to working with Niall and the rest of the team to build and deliver a pipeline of novel programmes that we hope will benefit the lives of cancer patients in the future."
For more information about Artios Pharma Ltd., please contact:
Artios Pharma Ltd.
Dr Niall Martin, Chief Executive Officer
Dr Nick Staples, Chief Business Officer
artios-pharma_simon-boulton_finalConsilium Strategic Communications
Mary-Jane Elliott, Lindsey Neville, Melissa Gardiner
Email: Artios@consilium-comms.com
About Artios Pharma Ltd.
Artios is a leading independent DNA Damage Response (DDR) company focussed on developing first-in-class treatments for cancer. Established in May 2016, the Company is led by an experienced scientific and leadership team with proven expertise in DDR drug discovery. Artios is building a pipeline of next-generation DDR programmes, including through a unique partnership with Cancer Research Technology (CRT), the development and commercialisation arm of Cancer Research UK (CRUK), and with leading DNA repair researchers worldwide. The Company's investors include SV Life Sciences, Merck Ventures, Imperial Innovations, Arix Bioscience plc, CRT Pioneer Fund (managed by Sixth Element Capital), and AbbVie Ventures. Artios is based at the Babraham Institute in Cambridge, UK.
About DNA Damage Response (DDR)
DNA Damage occurs in cells throughout the body every day. To counteract the harmful effects that DNA damage can cause, the human body possesses a network of DNA repair pathways, which act to correct the damage. This process is known as the DNA Damage Response (DDR). Defects in the body's DDR can lead to an increased risk of cancer. Human cells have multiple DNA repair pathways, but in cancer cells, some of these pathways are lost, which result in genetic instability. Changes to DNA repair pathways can also drive the growth of tumours. By inhibiting DDR in cancer cells that have impaired repair pathways, scientists can selectively kill cancerous cells. DDR inhibitors, therefore, have the potential to act as: single agents that selectively kill tumour cells through synthetic lethality; adjunctive therapy to overcome resistance to current cytotoxics, and potentiating agents to radiotherapy and novel therapies including immune-oncology treatments.
Artios Pharma's Management Team
Niall has extensive experience in the DDR field and in cancer therapeutics in general, both in small companies and pharma. Prior to joining Artios, Niall was a co-founder and Chief Operating Officer at MISSION Therapeutics, a company focussed on the commercialisation of expert research into ubiquitin pathways for the treatment of cancers and other diseases. During his time at MISSION, Niall helped establish the deubiquitylating enzyme (DUB) inhibitor platform, and raise more than £80 million in Series A and B financings.
Nick has more than 20 years' industry experience in life sciences, healthcare and capital markets worldwide. He was involved in working with SV Life Sciences to establish Artios and was responsible for the strategic agreements with CRT.
As a corporate and business development professional, Nick has led a range of international transactions and strategic projects including M&A, fundraising (more than £100 million to date), licensing, divestments and new business ventures. In addition to his role at Artios, Nick currently provides corporate and business development consultancy to TopiVert Pharma Ltd, another venture capital backed biotech company.
His previous positions include senior corporate and business development roles at Vectura, SSL International (acquired by Reckitt Benckiser in 2010) and Protherics (acquired by BTG in 2008). He was also formerly a life sciences equity analyst at WestLB Panmure and a management consultant in life sciences at PA Consulting. Nick gained a PhD in Biochemistry from the University of Cambridge.
Andrew Muncey, Chief Financial Officer and Company Secretary
Andrew brings over 30 years' experience in finance and management to Artios. He previously served as Co-founder and Chief Financial Officer of Acacia Pharma, and Chief Executive Officer of Amura Therapeutics. Andrew has been Chief Financial Officer or Finance Director of several healthcare companies, including MISSION Therapeutics, Bicycle Therapeutics, Kymab, and Virttu Biologics.
Dr Peter Harris, Chief Medical Officer
Peter has considerable experience in the development of cancer treatments, including DDR programmes, particularly their translation to the clinic.
Prior to joining Artios, Peter served as Vice President Oncology and Renal Medicine and Site Head for Genzyme Europe Research, with global responsibility for oncology translational research. He previously served as Chief Medical Officer at Algeta (acquired by Bayer AG in 2013) where he initiated the successful global registration study of Xofigo, formerly alpharadin, the first approved alpha-emitter to market.
Peter was previously Development Director at KuDOS Pharmaceuticals in Cambridge UK, where he was responsible for the preclinical and clinical development of DDR modifiers including Lynparza™ (olaparib). He also served as Head of Medical Affairs and chair of the global clinical operations group at ICI Pharmaceuticals (now AstraZeneca). After his BSc (Hons) at UCL, Peter gained his medical qualifications at the University of London.
Dr Harry Finch, Medicinal Chemist
Harry is working with Artios as an independent consultant to oversee all chemistry activities on behalf of Artios, on an interim basis, and he also serves on the Artios Board as a director.
Harry has a proven track record in drug discovery and development within the pharmaceutical industry. He has worked across a broad range of therapeutic areas including oncology and has notable expertise in respiratory medicine, where he most notably co-invented GSK's successful asthma drug salmeterol (Serevent™).
Harry previously worked at several biotechnology companies in the UK including Ribotargets, Vernalis, Argenta and Pulmagen Therapeutics, following a distinguished career in pharma which included Roche and Ciba-Geigy AG (now Novartis AG), and GlaxoWellcome (now GlaxoSmithKline) where he latterly became Director of Chemistry. Harry gained his PhD in Organic Chemistry from University of Manchester.
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Artios attending 38th Annual J.P Morgan Healthcare Conference in San Francisco, January 12-16 2020
Artios Pharma, MD Anderson and ShangPharma announce in-licensing agreement for DNA damage response inhibitor


Calm Global Information Technologies Limited is an Information Technology provider focused on providing IT solutions. CALM IT is set up to provide total solution in the health, education, document, financial, and relationship management.
For our organization to successfully achieve its goals and objectives, the following core values and philosophies are imbibed and displayed by each and every person from the Managing Director to the most junior staff.
All decisions and actions must lead to increased customer satisfaction and loyalty.
We will always ask the question, Can it be done better?
We adhere to best practices. However, we not only maintain standards, but ensure continuous business improvement.
Everything must be done as quickly as possible to satisfy internal and external customers.
Our facilities, work culture and people must compete favorably with those from any part of the world.
We work together as a team to achieve the set goals. Together Everyone Achieves More Success (TEAMS) is our watchword.
He was pioneer managing director of Cashcraft Asset Management limited and subsequently became the vice chairman of the company in 2013. Before Cashcraft, he worked in Internal Control at NIB/Citibank Nigeria and was pioneer Chief Inspector at Ecobank Nigeria Plc. At Ecobank, he managed various credit teams within the Corporate Banking Division and was also responsible for Remedial Accounts Management. As a member of the Ecobank Group Travelling inspection team, he was involved with setting up and review of processes and procedures within the Ecobank Group.
Bowo holds holds a first degree from the University of Lagos and is a fellow of the Institute of Chartered Accountants of Nigeria. He had a successful career with Deloitte, before setting up an accounting and consulting practice.
He is an Oracle Functional Consultant who has been involved in set ups for a number of Fortune 500 Companies in the United States. He is the Chairman of COPAD: Concern for Public Accountability and Development. He has also authored articles for publications in newspapers. He has presented papers to various organizations including the National Judicial Institute, Institute of Bankers, etc.
He has participated in numerous professional and general interest seminars and workshops, both locally and internationally.
Paul is a seasoned human resources and a legal practitioner of international repute, having worked in the largest oil corporation in Africa - Nigerian National Petroleum Corporation (NNPC) for over three decades until he statutorily retired in November 2014. He has robust and astute experience in administration and human resources practice as well as legal advice majorly in administration of estates, wills, corporate/commercial law practice, arbitration, mediation and dispute resolutions.
He earned bachelor's degree in Sociology and Law from Ahmadu Bello University and Lagos State University respectively. He also has Master's degree in Human resources from the University of Lagos. He is a member of Nigeria Bar Association, Chartered Institute of Personnel Management and Nigeria Institute of Management.
He is the principal partner at Ajetunmobi and Ajetunmobi law firm as well as PEIL Consultancy Limited.
Anogwi is an accomplished banker and chartered accountant, having attended training both locally and internationally. He is a graduate of Statistics from the University of Nigeria, Nsukka. He was a Federal Government scholar and the best graduating student in his class. He is a fellow of the Institute of Chartered Accountant of Nigeria (ICAN) and honorary senior member of the Chartered Institute of Bankers of Nigeria.
He is a former Executive Director in Spring Bank Plc, former Executive Director, Mainstreet Bank Limited, alumni of Lagos Business School and holds certificate in business excellence from Columbia Business School New York.
Alhaji Modibbo is a highly skilled professional with over 30 years experience in Banking, corporate finance, stock market operations and portfolio management. A results driven and customer focused individual with a proven track record of innovative problem solving and building strong relationships with strategic decision makers.
He is a graduate of University of Maiduguri, Masters in Business Administration and Banking and Finance from Bayero University and Consortium of Italian University, Italy respectively. He has also been trained locally and internationally. He is a Fellow of Chartered Institute of Stockbrokers, associate Certified Pension Institute of Nigeria, Institute of Management Consultants and Nigerian Institute of Management.
Before becoming the Vice Chairman at Tiddo Securities in 2016, Alhaji Modibbo worked at Stanbic IBTC, an investment bank, as the General Manager, Investment Banking, Public Sector and Non-interest banking.
Alhaji Modibbo has carried out national assignments as a member of the financial sector group of vision 20:20:20 coordinated by Federal Ministry of National Planning, Abuja and Contact group of financial sector strategy (FSS 20:20) anchored by Central Bank of Nigeria which included study tour to financial institutions in Dubai, United Arab Emirates.
The day-to-day business of Calm Global Information Technologies Limited is managed by Iranloye Gideon Taiye. He is a graduate of Business Administration, MBA (Marketing) and Fellow of the Institute of Information Management. He is trained and knowledgeable in Computer Communication and Networking. He has successfully managed IT infrastructure & enterprise application in an organization with more than 200 employees and 24 branches. His areas of competence are but not limited to Business Analysis, Automation Specification, Human Management and Customer Service.


Style and beauty | Medical News Today: Diabetes: Can cheese control blood sugar?
While Chan concluded in the paper that «insulin sensitivity of rats was improved by cheese independent of its fat content,» she also addressed the elephant in the room in the declaration of interests section.
«A representative of Dairy Farmers of Canada reviewed the manuscript prior to submission but had no role with respect to study design, data collection, analysis or interpretation, writing of the manuscript and its final content, or the decision to submit the manuscript for publication,» she wrote.


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Turbo - Lost Measure
1- Neon Spines (05:42)
2- Crystal Valley (04:52)
3- Liquid Silver (07:04)
4- Seven Skulls (05:21)
5- Liberator (08:28)
6- Ultraviolet (Healing Song) (00:57)
7- Controller (06:54)
8- City of Satellites (04:09)
9- Magnet (06:27)
10- Gate of Saturn (05:14)
11- The Tide (04:49)
Turbo Website samples myspace
The Hungarian band Turbo, established in 2005, has an impressive history since all band members are well-known in their home country. In 2007 they recorded an EP that brought them national fame. After intense playing, their eponymous debut had been chosen 'the best pop-rock album of the year'. More live concerts followed and now their new album has been released to enlarge their fame.
Turbo is categorized as an experimental progressive art rock band. I'm not sure if this description completely covers the music on Lost Measure. Most songs have a kind of retro sound of the seventies which can hardly be disliked. The guitars have a clear sound without excessive effects, so the experimental part is a bit difficult to get for me. On the other hand the keyboards sound simultaneously modern and classical. Neon Spines is a combination of a pleasant kind of power rock with the emotional side of Pearl Jam, while deep down inside a Rush tune keeps wandering through my head. Crystal Valley holds a fine rhythm; it's a true stadium song that will be a killer when performed live. Liquid Silver is going back in time; it reminds me of the sound of the eighties with some hints to Budgie. The Hammond organ in the background played by Dure Szatmári and the vocals by Balás Tanka just do the trick here. Seven Skulls strongly reminds me of the seventies mainly due to the singer. His voice in combination with the sound of the recording, provide for those pleasant flashbacks of almost forgotten times. The radio-friendly opening riff of Liberator is reminiscent of AC/DC, but again the Budgie-sound takes over, bringing some extra tension in the song. A special mention is in place here for guitarist David Vigh, who unlike the vocals and the keyboards, has a very modern approach on his six-string, using all the modern techniques to keep the sound well-balanced.
The short interlude Ultraviolet (Healing Song) leads to Controller that starts quietly, building up to a powerful climax with a lot of modern rock influences. At the beginning of City Of Satellites power punk is the first thing that crosses my mind, but the great sounding guitar changes this song into another perfect live piece. I can already imagine a jumping audience in front of a big stage. Magnet takes you back to the basics; it's a rather introvert track. However, it ends powerful when the sound of the guitars increases the energy of the song. Gate Of Saturn shows the qualities of the rhythm section; jazz trained drummer Javor Delov and the energetic bass player Jero provide for a perfect base for the guitars and the keyboards in this wonderful song. The Tide closes the album with modern electronics, grooving guitars and a strong rhythm section. The retro sounding voice of Balás Tanka makes sure that the balance in the song remains.
Turbo's second full-length album doesn't cover the basics for being a real progressive rock band in my point of view. What we do have is a perfect album for a band that plays live on all well-known festivals. Regarding the more or less radio-friendly songs, it won't be a problem to gather all the open-minded rock fans and give them a great time during one of the live shows. For me, I would like to be part of the audience when Turbo hits the stage. It would be great if Turbo get the chance to perform on festivals outside of Hungary. They really deserve it.
**** Pedro Bekkers (edited by Peter Willemsen)