Rolls-Royce Motor Cars will return to the Geneva Motor Show and debut its full current product portfolio for the first time on an international stage. Representing the near-infinite Bespoke possibilities at the heart of its record-breaking success in 2018, the marque will present one of an extraordinary collection of 25 Phantoms alongside the first publicly-revealed Bespoke Cullinan commission.
Rolls-Royce Motor Cars will return to the Geneva Motor Show and debut its full current product portfolio for the first time on an international stage. Representing the near-infinite Bespoke possibilities at the heart of its record-breaking success in 2018, the marque will present one of an extraordinary collection of 25 Phantoms alongside the first publicly-revealed Bespoke Cullinan commission. In addition, two powerful visions of Black Badge and a highly Bespoke Dawn will be revealed, each informed by the taste patterns of a younger, more assertive breed of entrepreneur drawn to the brand.
The Home of Rolls-Royce in Goodwood, West Sussex continues to be celebrated as a global centre of luxury manufacturing excellence and the remarkable business record set in 2018 – the greatest sales result in the brand's 115-year history - called for the marque to further expand. 200 new jobs have taken the total workforce beyond 2,000 for the first time while the company remains profitable, generating a financial contribution to its shareholder, the BMW Group.
Created for those who conceive and achieve the impossible, Tranquillity is an expression of Phantom's standing as the rarest and most desired object in the luxury world. This Collection is strictly limited to just 25 examples worldwide and available as both Phantom and Phantom Extended Wheelbase, which discerning collectors have already purchased.
For the precious few who commission a Phantom, the realisation of their personal vision represents a moment that sees them view the world from a rare place. Phantom Tranquillity is a statement piece for the visionaries who push beyond accepted limits. Named and crafted to celebrate the feeling of euphoric tranquillity one achieves within the car, this unique Phantom beautifully curates objects and inspirations from worlds beyond earthly bounds.
Within Tranquillity's Gallery is a design inspired by the X-Ray coded aperture masks used on the British Skylark space rocket. High energy radiation passes over and through the distinctive perforated pattern, creating a coded shadow on the layers beneath. The properties of the original radiation sources were mathematically reconstructed from this shadow and rendered in highly reflective stainless steel, 24-karat gold plating and space grade aluminium.
Space exploration is further manifested with a unique first for Rolls-Royce; the incorporation of meteorite within the Volume Controller, further enhanced with a polished gold grip that matches the gold finish in the Collection Gallery, creating a distinctive accent feature. This remarkable application of authentic Muonionalusta meteorite, which fell to earth in Kiruna, Sweden in 1906, is complemented by detailed engraving of the location and date of its discovery.
Inspired by the light and dark sides of the Moon, the interior colourway of Arctic White or Selby Grey leather integrates unique veneer combinations of gloss and satin, both with an exclusive metallic effect. Black gloss runs from the fascia onto all the centre consoles, while a satin finish is used for the upper glovebox and door armrests. Black gloss elements are highlighted with elegant stainless steel Pinstripes.
In both the Light and Dark variants, Bespoke Audio Speaker Frets are finished in yellow gold, complementing the additional gold elements throughout the car. These unique elements are inspired by the historic NASA 'Voyager' satellites that carried into space two gold records with sounds and images that portrayed the diversity of life and culture on Earth, for any intelligent extra-terrestrial life that might find them.
A unique embroidery detail on the Extended Wheelbase door panel matches the pattern on the Collection Gallery with tone-on-tone stitching for a subtle, crafted detail. A Bespoke 'Technical' yellow gold, vapour blasted and engraved titanium clock complement the interplanetary motif alongside an engineered titanium Spirit of Ecstasy with yellow gold accents.
Following its global launch in the peaks of the Grand Tetons, Wyoming, the world's media declared Cullinan unequivocally "Effortless Everywhere". This transformative all-terrain vehicle has now begun a remarkable Bespoke journey with the marque's patrons who continue to create truly personal expressions of their lifestyles. An exclusive Cullinan has been curated in recognition of this extraordinary adventure.
The Genève 2019 commission intelligently reconciles the distinct notions of luxury and utility that Cullinan embodies. The brand's hallmark five-coat high gloss paint finish is rendered with a Petra Gold hue and fine Navy Blue coachline, recalling the khaki shades favoured by explorers, while Navy Blue and Oatmeal interior appointments celebrate a similarly functional colourway wrought in the finest leather hides. In addition, natural Open Pore Royal Walnut veneer is jewelled with a Bespoke timepiece and highly polished aluminium Bespoke Audio speaker grilles, subtly referencing the technical capability of Rolls-Royce's proprietary audio system.
To the rear, the brand's Bespoke Collective of designers, engineers and craftspeople present Genève 2019's most indulgent expression of all-terrain luxury. Mounted within a removable Recreation Module modestly stowed in the motor car's boot, The Hosting Service embodies the notion of giving pause to extraordinary company and is perfectly appointed to enrich time spent with loved ones.
Once the motorised door is raised and drawer fully deployed, hosts are presented with an upper tier of Bespoke stainless steel cocktail and seasoning services and lower tier of elegantly stowed glassware and American Walnut serving boards. Should the user wish to present their guests with appetisers, two stainless steel dishes etched with the RR monogram can be removed from their Natural Grain leather holster in the centre of the Hosting Service and placed to one side in recessed, leather-trimmed coasters finished with aluminium bezels.
Aperitifs can be mixed in highball crystal glasses, discreetly frosted with the RR monogram, using the stowed zester, jigger, ice tongs and American Walnut muddler. A hidden compartment contains linen napkins to serve while paring knives, stainless steel drinking straws and a pepper grinder complete the set. This remarkable piece will be exhibited alongside Viewing Suite, two rear-facing, beautifully contemporary, leather chairs and a cocktail table stored in the rear compartment of Cullinan.
Celebrating the distinct personalities each Bespoke commission imbues on a Rolls-Royce motor car, the Genève 2019 Dawn is finished in a newly developed Blue Crystal over Milori Sapphire paint that incorporates a layer of lacquer infused with glass particles to create a playful shimmering crystal effect. The extraordinary coachwork has been complemented by the marque's carbon fibre Aero Cowling, trimmed in Navy Blue leather, creating the elegant silhouette of a two-seat roadster.
Dawn Genève 2019's cockpit is trimmed with Selby Grey leather afore and Navy Blue leather astern, highlighting the prominence of the driver's position. The spirited interior ambience is further enhanced with a Piano Milori Sapphire dashboard, hand-polished for 12 hours and delicately framed by silver pinstriping, while Open Pore Royal Walnut veneer, applied full bleed to the Canadel door panels, rear deck lid and centre console, introduces a soft lightness and haptic texture.
Since the introduction of the brand's family of Black Badge motor cars, younger, more dynamic patrons of luxury have responded by evolving the marque's bold alter-ego through their own highly personal Bespoke commissions. For the 2019 Geneva Motor Show, Rolls-Royce presents two powerful visions informed by the taste patterns of this new breed of entrepreneur who wishes to amplify the character of their Rolls-Royce.
Galileo Blue was selected to dramatize the dynamic substance of Black Badge Wraith, while Mandarin coachlines were applied to reflect an ongoing trend towards small but impactful contrasts within each commission's colourway. Inside, Arctic White and Navy Blue leathers are similarly specked with Mandarin accents on the seat piping and veneer pinstripes while a bold hexagon pattern is worked in fine cotton thread between the two rear seats.
Ghost is presented in Gunmetal with an Iced satin finish upper and deep gloss lower, yet, this masculine, utilitarian palette is similarly invigorated by Lime Green pinstriping applied to the motor car's wheel centres. Anthracite and Black hides are used for both front and rear seating while Lime Green piping and door pockets continue the exterior's theme. An embroidered pattern on the rear seat armrest speaks of the Technical Fibre veneer and combines vibrant fine cotton with soft leather, further expressing the coachwork's combination of gloss and satin qualities.
The Rolls-Royce Art Programme has supported a number of high profile artists in recent years, including Isaac Julien, Asad Raza, Dan Holdsworth and Yang Fudong. The world of art is one that the marque shares a clear affinity with; a commitment to creative expression, an exploration of technical and conceptual boundaries, and a willingness to take time in the search for quality and meaning.
The House of Rolls-Royce will preview a new work by artist Tomás Saraceno at the show, between 7-17 March, 2019. The artwork sees the artist create a new work in collaboration with a spider. Appearing as a floating galaxy, this artwork, woven by social and semi-social spiders, provides an encounter between shifting scales and phenomena. From the cosmic web to the minute dust particles collecting on the silken threads, the artwork shows that we co-exist on multiple levels with non-human beings. Following the show, the artwork will reside permanently at the Home of Rolls-Royce in Goodwood, West Sussex, from 28 March, 2019.


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Example sentences with the word bridesmaids, a sentence example for bridesmaids, and bridesmaids in sample sentence.


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Q: How to prove the following function has only one root in interval [0,1] How to prove the following function has only one root in interval [0,1]:
$f(x)=(1-x^b)^b-(1-x)$ where b>1 is a positive integer
Some hint so far:
we can easily prove that $g(x)=1-x^b$ has exactly one fixed point in [0,1]
If we can proof that $g(g(x))=1-(1-x^b)^b$ has exactly one fixed point in [0,1] then the result follows.

A: Hint for easier solution: $f(0) = f(1) = 0$ and $f''$ has only one root in $(0,1)$.

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Home » Health News » Inside a tumor: Purple bacteria visualize 'big eaters'
Inside a tumor: Purple bacteria visualize 'big eaters'
Cancer presents an ongoing challenge for physicians, particularly in the diagnosis and treatment of the disease. This is, amongst other things, due to tumor heterogeneity. A team of scientists from the Helmholtz Zentrum Muenchen, the Juelich Research Center, the Technical University of Munich and the Heinrich Heine University Duesseldorf has now shown that harmless purple bacteria of the genus Rhodobacter are capable of visualizing aspects of this heterogeneity in the tumors. With the aid of optoacoustic imaging, the researchers used these microorganisms to visualize cells of the immune system, so-called macrophages* (Greek for 'big eaters'), that also play a role in tumor development. Their research findings have now been published in Nature Communications.
Many cancers form solid tumors. Inside, such tumors reveal major differences at the cellular and molecular level. One of these concerns the localization and activity of macrophages. Although these cells are essential for a healthy immune system, they also play a key role in tumor development. With the aid of photosynthetic bacteria, new optoacoustic techniques, which indicate where such macrophages are present and active, have now been developed.
"We were able to demonstrate that bacteria of the genus Rhodobacter**, which are harmless to humans, are suitable as indirect markers of macrophage presence and activity," says Dr. Andre C. Stiel, head of the Cell Engineering Group at the Institute of Biological and Medical Imaging (IBMI), Helmholtz Zentrum München. Rhodobacter bacteria produce large quantities of the photosynthetic pigment bacteriochlorophyll a. This pigment enabled the researchers to detect bacteria in a tumor by means of multispectral optoacoustic tomography (MSOT)***.
How does the principle work? Macrophages engulf bacteria as part of their natural scavenging activity, which is known as phagocytosis. This alters the surroundings of the bacteria, their absorption of electromagnetic radiation and, as a result, also the optoacoustic signal. Rhodobacter bacteria thus act like sensors for scientists, providing them with information about the presence and activity of macrophages.
"In further steps, these bacteria will enable novel approaches to non-invasive technologies and so open up entirely new possibilities for innovative diagnostic and therapeutic procedures," adds Dr. Thomas Drepper, who heads the Bacterial Photobiotechnology Group at Heinrich Heine University Duesseldorf. In future, bacteria may be able to reveal the location of a tumor and also detect increased macrophage activity. Depending on their localization, the macrophages could provide information about unwelcome inflammations or the desired response to immunotherapies, and could ultimately be used to improve treatment strategies.
*As is known today, tumors harbour specific microenvironments. One of the components of the tumor microenvironment are tumor-associated macrophages. These scavenger cells are part of our immune system, but in the case of a cancerous disease they are involved in unwanted inflammation of the tumor tissue — a process that leads to the further progression of the disease.
**Rhodobacter occurs worldwide in stagnant and flowing water. The bacteria produce different pigments in order to carry out photosynthesis. These include bacteriochlorophyll a, which is suitable for MSOT examinations to localize solid tumors. Rhodobacter cells do not cause infections in humans.
***During a MSOT scan, light is initially converted into sound, then into visual information. Initially, a weak, pulsating laser beam is directed towards the body. When the beam encounters molecules and cells, they heat up minimally and respond with minimal vibrations, which in turn generate acoustic signals. These are then picked up by sensors and converted into images. The way in which the individual cells and molecules react to the laser depends on their optical properties — in this case, for example, on the properties of bacterial pigments.
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About course KE2070
KE2070 Transport Phenomena, Advanced Course 7.5 credits
Advanced course covering momentum, heat and mass transfer.
(Choose course offering)Doktorand,programme studentsStart 30/08/2021,programme students
Course syllabus KE2070 (Autumn 2019–)
Headings with content from the Course syllabus KE2070 (Autumn 2019–) are denoted with an asterisk ( )
The course is framed around the concept of transport equations that describe the distribution of concentration, temperature, and velocity in time and space. We will discuss how these equations can be derived for specific problems and in different coordinate systems. Various examples illustrating the use of transport equations are discussed, such as chemical and biological reactors, membrane separators, heat exchangers, cooling fins, and flows in pipes and channels. In addition, case studies that exemplify how software packages such as Comsol use transport equations to simulate coupled transport processes in complex geometries are analyzed and worked out in detail. Case studies deal with processes such as tubular reactors, absorption columns, fuel cells, and flows around heating elements. On the theoretical side, the course covers time-dependent diffusion, diffusion in concentrated systems, derivation of the Navier-Stokes equations, boundary layer theory, basics of turbulence, and multiphase flows. The concept of transfer coefficients and the use of Nusselt and Sherwood correlations is covered with examples and problems.
Transport phenomena deals with the exchange of mass, energy, and momentum between systems, which plays an important role in engineered and natural systems. The course provides a systematic analysis and fundamental understanding of transport phenomena and its mathematical description which builds the foundation of modern simulation software packages.
After passing the course the student will be able to:
apply the shell balance approach to derive differential mass and heat balance equations in Cartesian, cylindrical, and spherical coordinates
apply the generalized differential mass and heat balance equations and the Navier-Stokes equations to analyze transport problems
analyze transport problems in simple geometries and derive analytically the concentration, temperature or velocity distribution
analyze transport problems in complex geometries and calculate numerically the concentration, temperature, or velocity distribution using a simulation software
apply the concept of transfer coefficients to describe mass and heat transfer across interfaces
At least 150 credits from grades 1, 2 and 3 of which at least 110 credits from years 1 and 2, and bachelor's work must be completed, within a programme that includes:
75 university credits (hp) in chemistry or chemical engineering, 20 university credits (hp) in mathematics and 6 university credits (hp) in computer science or corresponding.
KE1030 Transport phenomena and engineering thermodynamics
SEM1 - Assignments, 3.8 credits, grading scale: P, F
Matthäus Bäbler
Course web KE2070
CBH/Chemical Engineering
Chemical Science and Engineering, Chemistry and Chemical Engineering
Will replace 3C1723


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GENERAC DEADLINE ALERT: Bragar Eagel & Squire, P.C. Reminds Investors that a Class Action Lawsuit Has Been Filed Against Gen • SPRUCE ALERT: Bragar Eagel & Squire, P.C. is Investigating Spruce Power Holding Corp on Behalf of Long-Term Stockholders and • The International Fellowship of Christians and Jews Celebrating 40th Anniversary in 2023 • Black CannaBusiness CEO Intensive and Multi-State Cannabis Company Parallel Launch 2023 National Education Series in Pittsburgh • Dollar General Announces 19,000th Store Opening • University of Phoenix College of Doctoral Studies Releases Whitepaper on Role of Demographics in Career Optimism • CLEANSPARK INVESTIGATION INITIATED by Former Louisiana Attorney General: Kahn Swick & Foti, LLC Investigates the Officers an • Susan G. Komen® Applauds House Introduction of Bipartisan Metastatic Breast Cancer Access to Care Act • Take in MGNY's Timeless Elegance at the MGNY Trunk Show • Trusted reusable nappy retailer commits to nationwide incentive scheme and eco education for first-time parents • CORRECTING and REPLACING Vibrant Emotional Health Names Dr. Tia Dole as New Chief 988 Suicide & Crisis Lifeline Officer • KIA AMERICA AND KIA GEORGIA CONTRIBUTE $100,000 TO THE AMERICAN RED CROSS OF GEORGIA IN SUPPORT OF TORNADO RELIEF INITIATIVES • THE DIOCESE OF ROCKVILLE CENTRE FILES PLAN OF REORGANIZATION • PALANTIR TECHNOLOGIES INVESTIGATION INITIATED by Former Louisiana Attorney General: Kahn Swick & Foti, LLC Investigates the • Catholics for Choice on the Murder of Tyre Nichols: Black Lives Matter is a Pro-Life Issue • Ziegler Closes $29,200,000 Financing For Bishop Gadsden • ZILLOW GROUP INVESTIGATION INITIATED by Former Louisiana Attorney General: Kahn Swick & Foti, LLC Investigates the Officers • CREDITORS COMMITTEE FILES REORGANIZATION PLAN FOR DIOCESE OF ROCKVILLE CENTRE; DIOCESE OF ROCKVILLE CENTRE FILES REORGANIZATION • GINKGO BIOWORKS ALERT: Bragar Eagel & Squire, P.C. is Investigating Ginkgo Bioworks Holdings, Inc. on Behalf of Long-Term St • "Extra-Strength" Formulation of Jeuveau® Demonstrates Effects Lasting 26 Weeks in Interim Phase II Data Results, Representin
Urban League On A "Green" Mission
Commentary by Marc H. Morial, President National Urban League
NEW YORK - In the great tradition of America's global defense of democracy, our nation has now entered another foreign conflict to protect and improve the lives of innocent civilians. While we applaud the inclination to rescue people in peril around the world, we wonder why that same urgency does not seem to apply to the millions of urban Americans still in the grips of the great recession who have been anxiously waiting for the United States to declare war on unemployment.
For the past several years, the National Urban League has been leading the call for action. With our current 12-point Jobs Rebuild America Blueprint, we have even offered Washington a winnable war plan, complete with a regime change strategy that will remove the scourge of high unemployment from our communities and replace it with a new era of jobs and opportunity. We will again put that strategy in the hands of White House and Congressional leaders during our State of Black America Legislative Policy Conference in Washington this week.
As the former mayor of New Orleans, I know that many lives can be lost waiting for the federal government to respond to a national crisis. And there is not a day that goes by that I don't get reports from our Urban League affiliates on the front line of the jobs crisis about the direct and collateral damage double-digit unemployment is inflicting on urban families throughout the country. That is why I am encouraged by the pro-active action of Congressman Emanuel Cleaver, who has developed his own war plan to defeat the tyranny of joblessness in his city.
Congressman Cleaver, who hails from Langston Hughes' childhood home of Kansas City, Missouri, and who is also the newly elected chairman of the Congressional Black Caucus, has been the driving force behind that city's promising Green Impact Zone. His plan echoes many of the elements of the National Urban League's call for national Green Empowerment Zones to attract investment and green jobs to neighborhoods with disproportionately high unemployment rates.
According to Congressman Cleaver, "Approximately 25 percent of the properties in the zone are vacant lots, and another one-sixth have vacant structures. Fewer than half of the homes are owner-occupied. Over the last two years, almost 20 percent of all mortgages were delinquent and median home prices for the area are less than $30,000."
The mission of the Zone is use to use a comprehensive green strategy with intense resident engagement to more rapidly push community change and create jobs. Established with Stimulus seed money, Kansas City's Green Impact Zone is being sustained with private-public investments in reduced energy consumption, low-income weatherization, transportation and infrastructure improvements, youth mentoring and job training with guaranteed employment upon completion. Together with the Entrepreneurship Center at the Urban League of Greater Kansas City, led by President and CEO Gwendolyn Grant, hundreds of sustainable jobs have been created as part of the project with many more to come.
Kansas City's Green Impact Zone is paving the way for the rebirth of a neglected neighborhood and is proving to be a powerful weapon in Kansas City's war on unemployment. We applaud Congressman Emanuel Cleaver for his leadership and urge Washington and the rest of the nation to follow his lead.
STORY TAGS: Urban League


We have a forum thread for this film, if you fancy talking about it click here!
Shaun of the Dead was a great movie, actually Ive been itching to watch it again.
Hell yea... I actually feel like seeing it again myself!
I can imagine. The horror!
Good to see you Cthulhu. I was slowly going mad!
It's good to see all of your names again.
Glad to hear both cats are making the most of their nine lives!
So have I EC, I'm still alive and around, lol. However, not much down at NGFL lately. But maybe I'll look back more.
Fear not everyone: The cat lives!


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Is dopamine dysregulation responsible for schizophrenia?
Post-mortem genetic analysis of the brains of patients with schizophrenia suggests that dysfunction of dopamine receptors in the caudate nucleus may be the cause of the disorder.
Researchers have identified a mechanism on the dopamine receptor, known as the autoreceptor, that regulates the amount of dopamine released by the presynaptic neuron. Impairment of this autoreceptor leads to poorly controlled dopamine release and excessive dopamine flow.
The researchers found that decreased expression of this autoreceptor explains the genetic evidence for schizophrenia risk and, using a suite of statistical routines, they showed that this relationship is likely causal.
"Our research supports the scientific hypothesis that too much dopamine plays a likely causative role in psychosis and precisely how this is based on genetic factors," said study researcher Daniel Weinberger, MD, director and CEO of the Lieber Institute for Brain Development. Medscape Medical News.
"Drugs that treat the symptoms of psychosis by simply blocking dopamine receptors have serious side effects… Theoretically, scientists could now develop therapies that target these faulty autoreceptors to treat this devastating disease with fewer effects. secondary," he said.
The study was published online November 1 in Natural neuroscience.
"Privileged location"
"Large international genetic studies known as genome-wide association studies (GWAS) have identified hundreds of regions of the human genome harboring potential risk genes for schizophrenia," Weinberger said.
"However, these regions are still poorly resolved in terms of specific genes, and treatments and diagnostic techniques are far from where they should be." Additionally, "treatments for schizophrenia address the symptoms of psychosis but not the cause," he said.
"For more than 70 years, neuroscientists have suspected that dopamine plays a key role in schizophrenia, but what kind of role, exactly, has remained a mystery," Weinberger noted. "It has held pride of place in the main schizophrenia hypothesis for over 60 years – the so-called 'dopamine hypothesis'."
Dopamine-reducing antipsychotic drugs "are the primary medical treatments, but they cause serious side effects, including an inability to experience pleasure and joy – a sad reality for patients and their families," he said. for follow-up.
The current study "sought to understand how dopamine acts in schizophrenia" using "genetic and transcriptional landscape analysis" of the post-mortem caudate nucleus of 443 donors (245 neurotypical, 154 with schizophrenia, and 44 with bipolar disorder).
Brain samples were from individuals of diverse ancestry (210 were of African descent [AA] and 2,233 were of European ancestry [EA]).
New treatment target?
The researchers performed an analysis of quantitative transancestral expression trait loci (eQTLs), genetic variants that explain variations in the expression levels of genes, which are expressed in the caudate, annotating "hundreds of specific traits to the caudate". cis-eQTL."
Then they integrated this analysis with gene expression that emerged from the latest genome-wide association study (GWAS) and transcriptome-wide association study, identifying hundreds of genes that "showed a potential causal association with schizophrenia risk in the caudate nucleus," including a specific isoform of the dopamine D2 receptor, which is upregulated in the caudate nucleus of people with schizophrenia.
"If the autoreceptors aren't working properly, the flow of dopamine in the brain is poorly controlled and too much dopamine is flowing for too long," Weinberger said.
In particular, they observed "expanded differential gene expression" for schizophrenia in 2701 genes in people with schizophrenia (compared to those without): glial cell-derived neutrophic factor antisense RNA (GDNF-AS1) was a "top-up" gene and tyrosine hydroxylase (E), which is a rate-limiting enzyme of dopamine synthesis, was a "down-regulated" gene. Dopamine receptors DRD2 and DRD3 were differentially expressed.
With that done, they looked at the effects of antipsychotic drugs that target D2 regions on gene expression in the caudate by testing the differences between people with schizophrenia who were taking antipsychotics at the time of death, those who were not taking antipsychotics at the time of death. antipsychotics at the time of death (n = 104 and 49, respectively) and neurotypical individuals (n = 239).
There were 2692 differentially expressed genes (DEG) between individuals taking antipsychotics compared to neurotypical individuals (false discovery rate [FDR] < .05). In contrast, there were only 665 DEG (FDR < 0.05) between those not taking antipsychotics and neurotypical individuals.
"We found that antipsychotic drugs have a dramatic influence on caudate gene expression," the researchers note.
They then developed a novel approach to "infer gene networks from expression data". This method is based on deep neural networks, obtaining a "low-dimensional representation of the expression of each gene across individuals". The representation is then used to construct a "gene neighborhood graph and assign genes to modules".
This method identified "several enriched modules for genes associated with schizophrenia risk". Expression representations captured in this approach placed genes in "biologically meaningful neighborhoods, which may provide insight into potential interactions if these genes are targeted for therapeutic intervention," the authors summarize.
"Now that our new research has identified the specific mechanism by which dopamine plays a causal role in schizophrenia, we hope to have opened the door to more targeted drugs or diagnostic tests that could improve the lives of patients and their families. ", Weinberger said.
No causal link?
Commenting for Medscape Medical News, Rifaat El-Mallakh, MD, director of the Mood Disorders Research Program, Department of Psychiatry and Behavioral Sciences, University of Louisville School of Medicine, Kentucky, called it "an excellent study performed by an excellent research group" which "fills an important gap in our research database."
However, El-Mallakh, who was not involved in the research, disagreed that the results show causation. "The data that can be gleaned from this study is limited and the design has significant limitations. As with all genetic studies, this is an association study. It tells us nothing about the relationship of cause and effect between genes and disease."
"We don't know why genes are associated with disease. Genetic overrepresentation can have many causes, and more so when the data is a convenience sample. As the authors noted, much of what they observed was probably related to the effect of the drugs. I don't think this study specifically tells us anything clinically," he added.
The study was supported by LIBD, the BrainSeq Consortium, an NIH grant to two of the authors, and a NARSAD Young Investigator Grant from the Brain & Behavior Research Foundation to one of the authors. Weinberger did not report any relevant financial relationships. Disclosures for other authors are listed with the article. El-Mallakh said no specific financial relationships relevant to the study, but said he is a speaker for several companies that manufacture antipsychotics.
Nat Neurosci. Published online November 1, 2022. Summary 1, Summary 2
Batya Swift Yasgur MA, LSW, is a freelance writer with a consulting firm in Teaneck, NJ. She is a regular contributor to numerous medical publications, including Medscape and WebMD, and is the author of several consumer health books as well as Behind the Burqa: Our Lives in Afghanistan and How We Escaped to Freedom (the memoirs of two brave Afghan sisters who told her their story).
For more information about Medscape Psychiatry, join us on Facebook and Twitter.
#dopamine #dysregulation #responsible #schizophrenia


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Big bank levy approved by Senate: Macquarie fails to dodge tax bullet
By Kelly Emmerton · Tuesday, 20 June 2017
The big bank levy announced in this year's Budget has been approved, despite widespread criticism and attempts by Macquarie, one of the five banks affected, to dodge it entirely.
The levy passed through the Senate with the support of the Labor and Greens parties, although Coalition senator Ian Macdonald voiced concerns about the Government taxing companies differently, saying, "I'm uncomfortable about that and I know that many in my party are."
The new tax, expected to raise $6.2 billion over the next four years, will apply to Australia's five largest banks - ANZ, NAB, The Commonwealth Bank, Westpac and Macquarie - and has been widely criticised as a lazy and ill-thought out policy.
Banks argued that it would damage their competitiveness on an international level and warned that the cost of the new tax would inevitably be passed onto customers - who were already stung with $4.41 billion in bank fees last year, according to the RBA.
The big four also pushed for amendments to the levy, including a sunset clause for when the budget returns to surplus, exemption for banks under considerable financial stress, and for the levy to be applied to foreign banks, such as HSBC, as well.
A Senate committee report agreed to a review of the levy in two years time and that the Treasurer should be able to suspend the tax for banks experiencing financial hardship. As for foreign banks, it said the levy would apply to any who met the "major bank" criteria - having assessed liabilities over $100 billion - but that so far none did.
Macquarie went one step further than the other four banks, arguing that it shouldn't be included in the levy at all. The bank stressed its minor market share, representing just 2% of the mortgage lending market and the same portion of the retail deposit market.
Macquarie estimated the levy would account for approximately 11% of its Australian earnings, and that given the scale of its business, "may have unintended and disproportionate consequences on its local earnings."
RELATED: Big bank tax to cost average $241 million each. Guess who's footing the bill?
On the other hand, smaller banks have come out in support of the new levy, with ME CEO, Jamie McPhee saying that "...in our industry smaller banks are disadvantaged considerably by the major banks' 'too big to fail' status."
He said the new levy would "further level the playing field" in the banking sector and that, "Australia's borrowers and depositors will be the ultimate beneficiaries from a truly competitive environment."
As it stands, the levy will come into effect on July 1, and be applied to Australia's five biggest banks - including Macquarie.
Kelly Emmerton
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Tim Knott
Tim Knott BSc (Hons) BVSc CertVOphthal MRCVS Veterinary Ophthalmologist
Tim graduated from the University of Bristol in the beautiful south west of England in 1995. Tim always wanted to be James Herriot but caught the ophthalmology bug in his first year at Vet School. He tried balancing the demands of general mixed practice and his growing interest for ophthalmology for the first 5 years of his career before finally realising that cleaning cow manure from under his finger nails before intra-ocular surgery was not in his or his patient's best interests. Tim set up a dedicated private ophthalmic referral practice, Rowe Referrals eye clinic, in 2000 followed by the equine ophthalmology consultancy service, the Equine Eye Clinic, in 2003.
Early on in his career, he realised that the biggest impact we can make on the health of our patients is by teaching. To this end he is proud to have served on the board of the British Association of Veterinary Ophthalmologists for over 10 years, he has examined and organised the Royal College of Veterinary Surgeons Certificate in ophthalmology for 7 years and is a member of the International Equine Ophthalmology Consortium - the IEOC. Tim also organises and helps to provide the British Equine Veterinary Association post graduate equine ophthalmology teaching for the UK. His ophthalmological mentor at Bristol was Professor Sheila Crispin and it was not long after Sheila's retirement that, with great pleasure, Tim returned to Bristol University to take over the clinical Ophthalmology teaching in 2008 as an external consultant.


Vladimir Putin has sent more Russian jets to fly by NATO countries this year than any time since the end of the Cold War more than two decades ago. In addition recent reports of Russian bombers running possible dry runs for nuclear bombing raids, and record numbers of Russian jets intercepted off the coast of Japan, NATO countries were forced to scramble their fighters to run off 26 Russian aircraft in just a two-day span earlier this week.
In fact, NATO countries have sent their planes into the sky about 100 times in 2014, just to tell Russian jets to get lost. The number is much higher when counting non-NATO allies such as Japan. But with two months still remaining in the year, even 100 is more than three times the total from 2013.
What is going on? Has Vladimir Putin lost his mind completely, willing to risk World War 3 for no apparent reason by sending his jets perilously close to European, Japanese, and even North American territory? Or does the Russian strongman have a master plan, of which the threatening aerial maneuvers are just a part?
That analysis is probably correct, but doesn't really go far enough, according to former Moscow Times editor-in-chief and current Bloomberg News foreign affairs expert Marc Champion.
According to Champion, the Russian jets buzzing NATO countries are Putin's form of "shoe-banging," a reference to former Soviet Union Premier Nikita Kruschev who, while speaking to the United Nations General Assembly in 1960, took off his right shoe and banged it on the podium — as a way to command attention, but more importantly, to lead the West into believing that he was crazy.
Just crazy enough to start World War 3 if pushed too hard.
Putin himself compared his global strategy to that of his Communist predecessor of more than 50 years ago, in an interview last week.
Today, Vladimir Putin and the Russians see former Soviet republics such as Ukraine as rightly part of Russia. But the United States and NATO see Ukraine and other such countries as their own, independent states, with the total right to decide their own futures.
Could the Russian jets sent by Vladimir Putin to harass NATO countries set off an even more catastrophic tragedy? That scenario is exactly what experts such as Keating and Champion, as well as NATO leaders, now fear.


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Leveraging Direction of Care in Workers' Comp to Address Drug Pricing
August 13, 2021 Workers' Comp

Direction of care can have a profound influence on reducing the impacts of high drug prices in workers' compensation. In our latest interview with VP of Government Affairs, we dive into the latest on drug pricing and direction of care.

Direction of care can have a profound influence on reducing the impacts of high drug prices in workers' compensation. In our latest interview with VP of Government Affairs, we dive into the latest on drug pricing and direction of care.
Shelley Callahan, Sr. Director of Marketing: We're here with Brian Allen, VP of Government Affairs, talking a little bit about drug pricing. It's a hot topic in workers' comp. Brian, what's going on?
Brian Allen, VP of Government Affairs: Well, Shelley – thanks, first of all, for visiting with me and you know, there's a lot happening with drug pricing and let's start at the beginning of the supply chain at the manufacturing level.
At the beginning of this year, there were over 580 brand name drugs that had price increases. And this has been a consistent trend year-over-year for the last several years. In 2020, there was a lawsuit filed against 26 manufacturers by 44 states accusing the manufacturers of price fixing. So we know that's going on at the generic level and that case is proceeding through the courts. Obviously it was delayed a little bit with COVID, but still a lot of activity there. So we know some very interesting things are happening at the manufacturing level.
And then, on the distribution level, you have some areas of fraud and abuse that we're concerned about. We're seeing, you know, hardly a week goes by where there isn't some prosecution of a practice somewhere for fraudulent prescribing of drugs. And we see that a lot in topicals. Topicals is really a big problem across the country in the workers' comp space, where you'll see creams that are, you know, two to $3,000 a month. And, really those drugs could be manufactured and probably purchased for less than a hundred dollars.
The other thing we see is the prescribing of really high cost generics drugs that have really high AWP and having large profit margins. We see some groups working on really pushing those kinds of drugs. And so, regulators around the country are really struggling, trying to figure out what to do about it. In fact, [recently] there was a hearing in Arizona and one of the big focuses was, how do we deal with these outlying drugs that are really super expensive? And how do we curb the fraud and abuse? And I know the chairman Schultz down there went on a fairly long diatribe about some of the problems that he's seeing in their system. And so it's really an issue that regulators are trying to grapple with.
One of the things that [could help fix it] is allowing for direction of care. One of the things that direction of care does is that it takes a lot of pressure off the regulators, because if they allow for direction of care, [they] can solve a lot of those problems. Through the marketplace and contract with good providers that play well in the sandbox. We can make sure that we're getting appropriate pricing and everybody wins at the end.
The dispensers win because they're getting good clean workers' comp business and we can make sure that their payments go smoothly, because they're not overpaying for drugs. The injured workers win because they're getting access to the right kind of care for the right reasons. And they're not being, you know, they're not being used as pawns in a scheme to make money.
So it's a good program and we've really promoted. And the challenge is that a lot of states don't really allow that to happen. They can allow it to happen voluntarily, whether they don't really make it so that an employer can really strive to direct care. So that's an area that we continue to work on regulatorily, but it is an issue and drug pricing is going to continue to be a problem. And so we get to a point where we can allow the marketplace to do the contracting and let that competition within the contracting help drive those prices down. We can't do anything to impact what happens at the manufacturing level. That's a federal issue, but the states can certainly do some things to help manage the prescribing abuses and other things that are happening at the state level and their workers' compensation systems.
Shelley Callahan: That's absolutely right, Brian, and I'm glad you brought up two things. One, just to be clear, that manufacturers are the ones that set the AWP for their drugs themselves, but what the regulators can do that you highlighted is doing direction of care. Can you tell us a little bit more about what direction of care is and why all states aren't already doing that?
Brian Allen: Sure. Well, direction of care, it's a pretty simple program. You allow employers to select a network of pharmacies that an injured worker can use to obtain their prescription care. It's a fairly simple thing.
The good news is for most employers and injured workers, is that the networks in workers' compensation are very broad. I know our networks encompass generally 90% or more of the local retail pharmacies in the state. You're keeping that business local. It's not getting fed to out-of-state mail order pharmacies or other things that aren't going to benefit the local community. So a lot of that business stays local and there's plenty of access to care.
There's not like there's a shortage of pharmacies in people's neighborhoods. And if we have 90% of those, then nine times out of 10, they're going to be able to pick the one – the one they're using is going to be in-network.
And the other thing that we do allow, for the most part, in our networks is the opportunity for a pharmacy to join it if they want to. So we have a very open policy in that way, and I think that's worked well for the industry. And I think it works well in workers' comp because it really provides the broadest access of care possible within the confines of a managed care program.
What that does is allows us to contract with those pharmacies at rates that are competitive. It gets rid of the outliers. If we have someone who wants to overcharge, they just can't play in the network. I mean, it's just that simple. And so you're able to, through a contractual arrangement, kind of weed out some of the problems.
You asked why states don't do it. I will tell you that I'm a little perplexed by it because I think most states don't do it because there's kind of a lack of understanding. There's commercial health plans and, you know, you can in Medicare. You have to go to an approved provider. you can't just go to anybody you want to reap the benefits of the program. I mean, you can go to any, you know, most insurance allow you to go to an out-of-network provider, but you're going to pay more out of your pocket. So most people try to choose in-network. So being in-network is not a foreign thing. It's something that everybody does and for pharmacy care in a commercial health plan, you have to go to an approved pharmacy. You just can't go to anybody you want.
So in workers' comp, for whatever reason, there's been a real resistance to direction of care. I think they fear that employees won't get good care if they are directed to a doctor or a treating provider by their employer. There's a sort of a mistrust, I think, that exists between the various groups. I think obviously employers have a vested interest in getting their employees healthy and well as quickly as possible. And I think most employers really do try to do the right things. So, I don't know. I think that maybe there was some mistrust, and it made sense years and years ago.
I don't know if that's really true today, but in pharmacy care for sure it shouldn't be as big of a hurdle to get over. Because, and no offense to the pharmacies out there, but there really isn't a lot of difference, you know, in pharmacy care from one pharmacy to the next. I've used multiple pharmacies in my life and they all take really good care of me and they all, you know, spend time with me and do the things that a pharmacist is expected to do, but it's not that dissimilar. So the primary product you're getting is the drug. Obviously there's some advice that comes along with it and some counseling that a pharmacist can give, but that is pretty consistent across the board. So it's not like there's, you can argue that they're going to get better care from one pharmacy to the next; they're pretty similar. And the pharmacies are all very professional and they do a really good job. And so there's not like a real disconnect between, you know, we're going to get really bad care from this pharmacy.
In fact, in some cases in the United States where there are choices and there is free, open choice, I think injured workers, in some cases they're getting taken advantage of, because I think they're getting products that they don't really need. We've seen evidence of that in the topical cream arena. There was a situation that we dealt with in New York a few years ago where patients were getting topical creams that they never asked for. And it looked like it was coming from their doctor because they had their doctor's name on the paperwork, but it turns out the doctor never prescribed it either. So somehow or another, they were getting these creams. And so they get taken advantage of, and I think having a network where there's broad access to pharmacies that an injured worker could choose from and allowing them to weed out some of the problems is really a positive thing. But it's been a hurdle.
I know the pharmacies typically don't want direction of care. They want choice, but in workers' comp where you've got 90% of the pharmacies available to an injured worker and an open policy where we'll allow any pharmacy that wants to participate. To me, it seems to make sense because it's a way, and it takes a lot of heat off the regulators.
Regulators are constantly trying to play catch up with the people who are abusing the system and we work and get laws and rules passed and they find another loophole and they exploit that loophole. Then we get to close that loophole and then it opens up another loophole somewhere. And it's just an endless game of whack-a-mole where you're trying to just beat back the wolves from the door.
If they went to a direction of care model, they could take a lot of the pressure off the regulators. The marketplace would put its own sort of guard rails in place, and you wouldn't have to deal with this constant battle of trying to figure out how do we close these gaps and how do we close these loopholes and make sure that people aren't abusing the system. The best way to do that is through contractual arrangements, because we can control that in our contracts.
We have found that our pharmacies in our network are good players. They do a fantastic job. They do it at a fair rate. We try to do everything we can to make sure they maintain profitability. We want to make sure that our payers aren't overpaying for medications. And there's a lot of competition in that space. So the payers have all the leverage in the world to keep negotiating prices down and they do, and they're very good at it. For me, it just seems to make a lot of sense, and I've never understood the resistance to it.
I know right now in a lot of states, the local pharmacies, they fight against direction of care. But what they don't realize is that millions of dollars are going out of their state to other pharmacies located in states that that don't benefit them and that's money that could be there in their shops, helping them. So, I think people don't embrace it and I hope they do. I think it'll solve a lot of problems.
Shelley Callahan: Thanks, Brian, the best care at the best price and making sure that at the end of the day, all injured workers are well taken care of. So we appreciate your, your insights and your passion. Join us again on the mPower podcast.
Learn More About Direction of Care >
VP of Government Affairs
Brian Allen is a nationally recognized policy expert for workers' compensation and insurance issues across the country. Allen currently serves as Vice President of Government Affairs for Mitchell's Pharmacy Solutions team. In this role, Allen provides insight into new legislation and regulations in the industry, authors articles and blogs for industry publications and frequently speaks at conferences across the country.
Dave Torrence: Top Three Workers' Compensation Trends to Know in 2022
Is the Supply Chain Creating Critical Drug Shortages?
Washington State Formulary Update
Applications of Predictive Analytics in Workers' Compensation


Would you recommend Swappy to a friend?
It shoulds feature the value of each item and works along with it. This way, each customer will get an item with the same value of the one he gives.
A peer to peer rental marketplace, all insured through us.


The world's best breakers will meet up at Amsterdam's Westergasfabriek for the 14th Red Bull BC One World Final on November 4. The excitement is building with just ten days left until Red Bull BC One hits the capital city for three intense days of Hip Hop celebration. After months of preparation and a long journey of local Cypher events in over 30 countries, all eyes are on the best dancers in the world who will showcase their mastery of breaking in what promises to be an epic world final – the dancers are about to give it all to claim the 2017 Red Bull BC One belt.
AMSTERDAM (NED) - The capital city, known for its artistic heritage, canals, narrow houses, and its numerous bike paths, will host the Red Bull BC One World Final for the very first time in one of the city's thriving creative hotspots – Amsterdam's Westergasfabriek. The world's top 16 breakers representing 9 different countries will hit the stage on Saturday, November 4, in hopes of claiming the esteemed title of Red Bull BC One World Champion.
The true essence of the Hip Hop culture is found in its unique collective consciousness: the creative, causative force behind Hip Hop's elements, prompting many dancers to stress that Hip Hop is not something one does, but rather something one lives. Some dancers emphasize on style and power moves, some put their emphasis on power moves and their combination, and others show their style and individuality by footwork and freeze. The one-on-one battle format will let the dancers show not only their mastery of the breaking essentials but also their overall style and individual expression. With the level of competition and the talent rising every year, Crazy Legs (USA), Hong 10 (KOR), Niek (NED), Intact (UKR), and AT (FIN), who are sitting in the judging panel – will have a hard time to identify THE breaker who can claim the title.


Download and fill out Lepi and Associates rental application.
Lepi and Associates are your rental specialists.
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Lepi and Associates Find your rental property quickly and easily.
Lepi & Associates want to sell commercial real estate.


text:
Q: playframework ProtocolException invalid message I have a funny phenomenon:
If I start a blank index.html page with this controller:
public class Application extends Controller {
    public static void index() {
        render();
    }
}

I don't see the index page but get the offer to download a file with this content:
FHcodeProtocolExceptionmessageinvalid message tagZ

What is the magic here?

A: Try to change the HTTP port in your application.conf (default is set to
9000).


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Opera Mail (dawniej M2) – klient poczty e-mail, grup dyskusyjnych, IRC oraz czytnik kanałów RSS i Atom firmy Opera Software ASA, dawniej zaimplementowany w darmowej przeglądarce internetowej Opera, obecnie dystrybuowany wyłącznie jako osobny produkt dla systemów Mac OS oraz Windows.

Pomimo niewielkich rozmiarów i wymagań, Opera Mail obsługuje konta POP3 i IMAP, grupy dyskusyjne i kanały RSS i Atom. Posiada także wbudowany moduł do ochrony przed niechcianymi wiadomościami.

Interfejs programu różni się pod wieloma względami od standardów, obecnych w innych programach. Powodem tego była pełna integracja klienta poczty z przeglądarką stron WWW.

Opera Mail używa jednej i tej samej bazy danych dla wszystkich wiadomości. Unikalną cechą jest możliwość zastąpienia folderów tzw. "widokami". Wiadomości są dzielone ze względu na status (odebrane, wysłane, nieprzeczytane itp.), załączone pliki (graficzne, wideo itp.), grupę dyskusyjną, lub też własne kryteria oparte na tak zwanych "filtrach". Jedna wiadomość może więc pojawiać się w kilku widokach.

Opera Mail wyświetla zarówno wiadomości w formacie tekstowym, jak i HTML, używając do tego silnika Presto. Tworzenie wiadomości odbywa się w trybie tekstowym oraz (od wersji 10) HTML. Dodatkiem do klienta poczty jest prosty menedżer kontaktów.

Od wersji 11.60 Opera Mail zostało mocno rozbudowane o między innymi nowy układ poczty, możliwość sortowania według wątków, daty, czy flagowania.

Od 27 maja 2013 Opera Mail była dystrybuowana jako oddzielny produkt dla systemów OS X i Microsoft Windows. Od wydania 1044 w dniu 19 lutego 2016 do chwili obecnej dalsze prace nad nią zostały wstrzymane.

Zobacz też
 Opera
 poczta elektroniczna
 porównanie programów pocztowych

Linki zewnętrzne
 Opera Mail
  - oficjalne forum użytkowników przeglądarki Opera

Przypisy

Programy poczty elektronicznej
Oprogramowanie firmy Opera

redpajama_set_name: RedPajamaWikipedia


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PressPress ReleasesPhotosVideoRSS Feeds
Press ReleasesBusiness & WholesaleCompanyNetworkProducts & ServicesResponsibilitySponsoring & Advertising
Business & Wholesale
Sponsoring & Advertising
Back to Telefónica Germany
FONIC: Ralf Gresselmeyer to become new Managing Director
MUNICH. Ralf Gresselmeyer has been appointed new Managing Director at FONIC. Ralf Gresselmeyer will take over the responsibilities of Kai Czeschlik, who is leaving the company at his own request to enter new challenges.
Ralf Gresselmeyer has many years of industry experience in various functions. Most recently, the 38-year-old was responsible in his role as Vice President at Telefónica Germany for the landline business and has significantly promoted the successful development of the DSL range. Since 1999 Ralf Gresselmeyer worked for AOL and headed the product management before taking over the position of head of marketing of HanseNet. Amongst other things, there he was in charge of launching the mobile tariff "Alice Mobile" in the form of a Mobile Virtual Network Operator (MVNO) in Germany.
"With Ralf Gresselmeyer we have found the ideal candidate for the position," says René Schuster, CEO at Telefónica Germany Holding AG. "FONIC stands for the simple and fair mobile phone tariff including full comfort. Ralf and his team will further develop the mobile and service offerings and will sustainable push the strong position of FONIC within the market." FONIC GmbH is a subsidiary of the Telefónica Germany Holding AG and provides clear and fair telecommunications offers at attractive prices within the network of O2. The mobile offers of the brand FONIC are sold online at www.fonic.de and at over 15,500 sales outlets in Germany.
Telefónica Deutschland Holding AG, listed at the Frankfurt Stock Exchange in the Prime Standard, and its wholly-owned, operationally active subsidiary Telefónica Germany GmbH & Co. OHG belong to Telefónica Europe and are part of the Spanish telecommunication group Telefónica S.A. The company offers its German private and business customers post-paid and prepaid mobile telecom products as well as innovative mobile data services based on the GPRS, UMTS and LTE technologies with its product brand O2. In addition, the integrated communications provider also offers DSL fixed network telephony and high-speed Internet. Telefónica Europe has more than 103 million mobile and fixed network customers in Spain, Great Britain, Ireland, the Czech Republic, Slovakia and Germany.
About Telefónica Deutschland
Fixed network
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Consumer Portal


Discription: Edition of 100 hand numbered copies.
Mecha/orga is the sound project of Yiorgis Sakellariou, a Greek composer of experimental electronic music, member of the Athenian Contemporary Music Research Centre and the Hellenic Electroacoustic Music Composers Association. Active member of the Greek experimental music since 2003, Yiorgis has released musical works in labels like absurd, OtO, Monochrome Vision, Triple Bath etc. He is also the founder of Echo music, an independent Greek label since 2004 that is focusing on contemporary audio.
"41:38" album based on two older compositions of 2009 and 2011, reworked in December of 2013.The two pieces are based on various field recordings from the archive of the artist, which they are used unedited or even after electronic processing. The phonographic material was mixed and edited together, creating a sound collage of environmental music.
Consisting of two earlier pieces that Sakellariou exhumed and reworked.
The first begins with in extremely rapid tapping, as of a hard rubber ball on a wooden surface, but far faster and more regular than humanly possible. It sounds like more than one item in action, as what begins as roughly synchronized slips in and out of rhythm, creating small wavelets of patterns; really great. The same rhythm is eventually replicated in light, metallic fashion for a little while, again to wonderful effect. The ball-like object drops out, the metal lingers then collapses into an entirely other sound-world, all dark, cavernous hums with a mysterious, misty aspect, but it returns with a vengeance a few minutes later, now supported by this subterranean rushing river. Once again, it subsides into the dark, but a more troubling one, boiling a bit. A fine track, great to hear with one's head between the speakers.
The second track sounds almost as though it picks up at the other end of that underground tunnel, the liquid bubbling up into an adjacent area, building to a roar and, as before, collapsing, but this time into an urban environment, some bustling business, maybe the back room of a restaurant, boxes and such being tossed around. The scene abruptly skews and we're (I'm imagining) inside a moving truck, its contents (bottles in baskets) jouncing against one another, an odd, repeated, tonal two-note pattern permeating the air (many loops in effect here). A vast rush of sound, that pattern still dimly heard, like two distant marimba notes.More shifts, always clearly in human territory, maybe airports. Thing get a bit hazy here and, to me, don't quite cohere as well, but it's never boring, just disorienting, which might not be a bad thing. The piece returns to form with a particularly brutal, mechanical loop, really excellent, before drifting off.
Yiorgis Sakellariou: field recordings, processing, etc.
Unanticipated discoveries can come about as we revisit sounds that were left untasted – when not altogether forgotten – since when we handled them at first, either physically or perceptively. This is what happened to Yiorgis Sakellariou, who usually hates looking back at what he's already heard or used. This time the infrequent choice of fishing in the archives yielded consequences which were deemed serviceable for publication; to this we heartily agree. Divided in two extended segments, 41:38 is a downreaching album of field recordings and coexisting moods juxtaposed with semiconscious exactitude. The episodic vacancy of the acoustic imagery opposes to dramatic closeups of selected "violent" emissions (for example, the clangorous braking of a train). The recognition of this contrast is presumably the necessary code to deliver the mechanism of retention from the inflexibility that would, in a way, spoil the party of reminiscence.
Mecha / Orga is a principled assembler. The outstanding attributes of his work emerge all over the program, including environments detected elsewhere, perhaps in different forms and shades. The compositional aspect is approached with the right dose of discernment, particularly in regard to a functional sequencing of the events. A cadenced impulse can be followed by a ferrous efflorescence, then we're conquered by an accumulation of remotely resonating partials that may derive from a strong air current (or a processed espresso machine, depending on the point of view). We're not given a surplus of handles to grip at, thus avoiding the inclination to guess, classify – and ultimately degrade – the components of a process of aural coalescence better comprehended as an evocative integrity, accepting its intrinsic coherences and (mild) contradictions without extravagant speculations.


Picture and Sound Rushes (1971) includes synchronous sound footage of Fisher explaining the premise of the film that is being shot. He improvises his dialogue from notes to which he refers while the camera is rolling. At predetermined thirty-second intervals, the film alternates between sync sound, wild sound over black, MOS or silent footage of Fisher speaking, and silence over black. After the segments of silence over black (called the "null case" in the film) Fisher's reappearance comes as something of a relief.


This is another beautiful ad from Google. This time, it's from Google India extending the "The Web is What You Make of It" campaign with a spot about Tanjore, an ancient Indian art form that seems to be fading away from the modern every day world.
The ad tells the story of a Tanjore artist who learns to make a website, and in doing do, starts brining back the ancient art (and with it the riches) from extinction via the suite of Google tools in a beautiful stop motion piece. I really love Google telling stories.


Inspired by Indian beauty rituals. Body scrub blended with beauty oil and sugar cane, this scrub will polish the skin leaving a smooth radiant complexion.
Apply to dry skin (dampen to soften) and buff in friction motions, shower off. 1-2 times per week.
Powerful body scrub - exfoliates & softens skin, leaving it smooth and hydrated. Fragranced with Incense, Musk & Vanilla.


The Office of the Mayor has compiled a list of substantially all industrial properties available for sale or lease in Waterbury. This significant new tool features a comprehensive mapping system to provide potential site selectors with more in-depth information on those properties. A user can simply click an area on the map and view the property listings for that specific area. The names of the agent/broker, along with their telephone number, are posted with the list. The Mayor's Office will update the webpage, as appropriate, every three weeks to reflect needed changes. Any brokers with industrial property listings only should contact Joe McGrath at 203-574-6712 or jmcgrath@waterburyct.org.
Click here to view a Interactive Map of State and Municipally Owned Priority Brownfield Sites in Connecticut.
Click here to view WDC's Community Impact Map.
562 Captain Neville Dr. (industrial) 29,151 SF available. Lease: $4.25 NNN Exceptional manufacturing/production facility.
Great I-84 exposure and access.
Fully air conditioned, good power distribution, abundant parking and good loading access (additional possible).
65,000 +/- SF warehouse mill bldg. on 2.5+/- acres. Bldg footprint 12,500 SF w/ 4 floors. 10,000 +/- SF trucking terminal attached to warehouse w/ 28 docks. Active rail siding w/ 8 doors. New roof & fenced in, 4000 pound capacity freight elevator. Enterprise Zone benefits. $950,000.
193-195 Grand St. (commercial) 29,436 SF available. 3 story commercial building. $15 NNN.
196-250 Mill St. 160,000 SF +/- mill bldg on 2.6 acres. Also a 15,000 SF single story, free standing flex bldg on the property for warehouse or retail. Lease price: TBD. Sale price: $890,000.
560 & 556 Wolcott St. Retail bldg currently operates as a hair salon. Total: 2070 SF. Neighboring multi-fam investment property needs renovations. Total: 2346 SF Potential development site w/ 1.5 acres +/- , frontage: 195 feet. Sale Price: $425,000.00 for all real estate.
1074 Wolcott St. Busy Retail Area on Wolcott line. 18,340 SF. Land Acreage: 3.15 with 2 curb cuts and traffic light. Ideal for medical, pharmacy, automotive, etc. Lease pricing depends on "as-is" or refurbished to tenants specifications.
10 Chase River Road 2400 S/F Retail-Office. Great traffic location. Building and pole signage available. Currently finished as a showroom and office with side drive in loading door. Ideal for many retail or office uses looking for high visibility. $2,600 per month +utilities. Contact Brian or Ed Godin, 203-577-2277.
56 Eagle Street 34,750 S/F Industrial on 1.01 acres 22,000 S/F on main level 8,300 S/F on 2nd floor 4,200 S/F on 3rd floor Major renovations and upgrades have been done in 2001 Heavy power IG-heavy industrial zoning Well located near Route 8 in the Enterprise Zone Sale: $295,000.00 Lease: $4.00 PSF NNN. Contact Ed Godin, 203-577-2277.
61 Interstate Lane Modern Upscale Office Space. Move-In Condition /Cummins Diesel Generator / Ample Parking Easy Access to I-84 at Exit 25. Small Warehouse could be available (2,000 S/F). Priced to Lease: Option 1: Main Floor Office Space 6,193 square foot office space Lease asking price: $10 PSF + Utilities Option 2: 2nd Floor office space 5,350 square foot office space Lease asking price: $9 PSF + Utilities. Contact Brian or Ed Godin, 203-577-2277.
Sale Price: $695,000.00 Lease Rate: $2.75 - $4.50 NNN. Contact Ed Godin, 203-577-2277.
115 South Main Street 22,850 S/F Office / Retail Building. Ideal for downtown owners/developers. Visible downtown location with easy access to I-84. Close proximity to UCONN & Palace Theater. Walking distance to restaurants/banks & public services. Ample parking. Sale Price: $850,000. Contact Brian Godin, 203-577-2277.
95 North Main Street 18,630 S/F Office/ Retail Building. Four Floors/ Elevator on busy North Main Street. Ideal for downtown owners/developers. Visible downtown location with easy access to I-84. Walking distance to restaurants/ banks & public services. Asking Price $650,000.00. Contact Brian Godin, 203-577-2277.
120 Store Ave Attn: Investors or User 3,939 S/F Retail/ Office Building Previous Post Office Tenant: Day Care is currently month to month willing to sign long term lease (5 year) Cap Rate 10.7% Asking Price: $277,000.00 Contact Brian Godin, 203-577-2277.
61 Interstate Lane Modern Upscale Office Space Move-In Condition /Cummins Diesel Generator / Ample Parking Easy Access to I-84 at Exit 25 Small Warehouse could be available (2,000 S/F) Priced to Lease: Option 1: Main Floor Office Space 6,193 square foot office space Lease asking price: $10 PSF + Utilities Option 2: 2nd Floor office space 5,350 square foot office space Lease asking price: $9 PSF + Utilities Contact Brian or Ed Godin, 203-577-2277.
26 North Main Street Attention Restaurant Entrepreneurs 7,510 +/- S/F Turn- key Operation on the Green Highly Visible Downtown Location Footsteps from The Palace Theater, UCONN campus and multiple State and Municipal buildings Sale price: $469,900.00 Lease Rate: $3,000 / mo. + NNN + Utilities Contact Brian Godin or Mike Grieder, 203-577-2277.
127 SCOTT ROAD 2200 SF AVAILABLE. RETAIL STRIP CENTER, RETAIL AND OFFICE, EASTEND WATERBURY, RETAIL AND PROFESSIONAL AREA, HIGH TRAFFIC, INTERSTATE SERVICE, AREA OFFICE SPACE, 6 Offices, Reception, Open Area, Bathroom, Break Room, Easy on and off to I-84,RENT: $9.00 NNN Contact BOB BOWDEN, 203-573-0342.
231 Bank Street 1000 SQUARE FEET Office Space, Excellent Condition, 3 Private Offices, Open Reception area, Kitchen, Move in Condition Fine Oak Molding and Doors. Near Diorio Restaurant and Hotel At Entry Ramps to I 84. Monthly Rent: $1,400.00 Gross Including Utilities. Contact BOB BOWDEN, 203-573-0342.
Watertown Avenue AVAILABLE GROUND LEASE or BUILD to SUIT. Pad site available, 400 +/- feet of frontage on Watertown Avenue, Morning drive side location, Join a new Cumberland Farms, Dunkin' Donuts, Subway and Verizon Wireless. Can accommodate up to 14,000 sq. ft. of retail Located on corridor to Route 8 and I-84. Pricing: TBD Contact Ralph Calabrese or Tony Valenti, 203-573-0342.
1249 WEST MAIN STREET RETAIL PAD SITE, 10,000 SF BUILDING FOOTPRINT, +- 1. 5 ACRES1.5 ACRE PAD SITE IN NEW RETAIL STRIP CENTER. HIGH QUALITY AWARD WINNING CONSTRUCTION. PROFESSIONAL AREA HIGH TRAFFIC OFF I 84 EXIT RAMP BUILDING SIZE 10,000 SF. MARKET AREA DEMOS: POPULATION: 150,000, INCOME: $66,000, TRAFFIC COUNT: 17,200. GROUND LEASE $65,000 NNN Contact Ralph Calabrese or Tony Valenti, 203-573-0342.
137 MATTATUCK HEIGHTS High Quality Manufacturing Assembly Building. 45,000 SF Rentable. Modern Industrial Park Setting. 18 to 20 FT Ceiling, +- 5800 SF Newly Renovated Office Space, 4 Loading Docks, 3 Drive In Doors, New Roof, New HVAC, 100% AC, Upgraded Lighting, Electrical Service For Manufacturing. Price: $6.00 NNN Bob Bowden, 203-573-0342.
205 INTERSTATE LANE Industrial Building. 1100 SF Office, 1500 SF Warehouse, 4,600 Flex/Office, 7,200 SF Combined. Modern Masonry, Building, Industrial Park, Just off I 84. 1 dock, 1 drive in door, Gas, Water, Sewer, 14 ft Ceiling, Large Parking Area, 2 Acres. Available For Sale. Price: $6.50 NNN Bob Bowden, 203-573-0342.
24 Leavenworth Street 7,600 SF office space. Contact Tom Gessler 908-306-1600.
21 West Main Street 7,600 SF retail space with drive through and bank vault. Contact David Theroux 203-777-1766.
67 Freight Street 4,000 SF warehouse space. Contact Ed Godin, 203-753-5800.
447 Meadow Street commercial with fully equipped kitchen and new hood system. Contact Dom Giglio, 203-755-0030.
228 Meadow Street new retail/office. $14SF. Contact 203-755-0030.
193 Grand Street 4-story, 29,000 SF office building designed by Cass Gilbert, across from City Hall. Contact John Famiglietti, 203-753-4116.
95 West Main Street four floors, first floor retail. Contact Gerry Matthews, 203-753-5800.
60 North Main Street former bank, 1st and 3rd floors available. Contact Jack Freidman, 917-837-9581.
36 North Main Street 12,000 SF mixed use. Contact Joseph McGrath, 203-574-6712.
32 North Main Street former restaurant. Contact Sheldon Haag, 860-908-3153.
26 North Main Street former pub facing City Green. Contact Gerry Matthews, 203-468-8379.
35 East Main Street Contact Phil Nargi, 203-410-3735.
78 East Main Street four story, 1st floor retail. Contact Dave DeRosa, 203-753-3401.
95 Scovill Street office suites available from 1,000 to 50,000 SF. Contact Gerry Matthews, 203-753-5800.
175 Union Street former Timexpo Museum, 14,000 SF. Contact 203-755-0030.
38 Bank Street upper floor need fit out. Contact Phil Nargi, 203-410-3735.
68 Bank Street former grill first floor, upper floor renovated apartments. Contact Parag Mehta, 212-563-2250.
77 Bank Street Russell Building, upper floor vacancies. Contact Mark Forte, 203-232-0487.
83 Bank Street renovated office space, first floor retail. For sale or lease. Contact John Famiglietti, 203-753-4116.
34 Brook Street 2-story, partially equipped restaurant closed to Palace Theater and Waterbury UConn. Contact John Famiglietti, 203-753-4116.
101 South Main Street Three stories available, 1st floor restaurant. Contact Omar Lohbibi, 914-497-5322.
108 Bank Street 5,500 SF. Contact Phil Nargi, 203-410-3735.
114 Bank Street iconic former department store. Public funds potentially available for renovation. Contact Joseph McGrath, 203-574-6712.
231 Bank Street storefront office. Contact Bob Bowden, 203-573-0342.
23 Commercial Street Warehouse available for lease. From 800 SF up to 34,675 SF of space is available. Contact John Famiglietti, 203-753-4116.
158 Manor Avenue 3,352 square feet and can be divided into two units. The lease price is $16.50 per SF triple net. Contact John Famiglietti, 203-753-4116.
185 Huntingdon Avenue 26,700 square foot industrial building on 5.5 acres. The first floor is 11,700 square feet, the second 13,000 SF. It is for sale for $695,000 with owner financing available or for lease at $3.50 per SF triple net. Contact John Famiglietti, 203-753-4116.
1200 South Main Street 18,000-square-foot building on 4.5 acres near the Naugatuck River. It is a flex building with multi-tenants, all with short-term leases. The price is $775,000. Lease with option to buy will be considered. Contact Tom Hill III, 203-755-4455.


Here are playoff implications for week five of the NFL season. The purpose of this feature is to highlight games that have a significant impact on the playoff picture (see this post for background).
This week's highest leverage game is an inter-conference matchup between the Bengals and the Cowboys. Both teams are in the playoff hunt, each with a decent chance at winning one of the wild card spots (making for a lot of teams with a rooting interest).
The lowest leverage game pits the Patriots (with Tom Brady) against the Browns. The Patriots playoff odds only swing by 3%, from 95% to 98%, depending on the outcome of this game. As for the Browns, this game actually has no statistical significance on their 0.03% chance of making the playoffs this year. On the bright side, they already have a 50% chance of picking first in the draft next year.


Taking you south from Christchurch, this 10 day includes the majestic scenery of the lower South Island. Beginning with the large open spaces of the McKenzie Country and Mt. Cook National Park, you then travel to the coast and the Scottish influenced city of Dunedin with its nearby wildlife havens. In Fiordland there is a full day to explore Milford Sound including a Real Journeys Nature Cruise, before you continue to the mountains and lakes of the Southern Lakes region.


At The Langley Academy, we are committed to giving all of our students every opportunity to achieve their academic targets, by taking into consideration their varied learning needs. We offer a broad, balanced curriculum with high expectations for all children. We also strive to be a fully inclusive school and actively seek to remove the barriers to learning through quality first teaching and extra interventions where necessary.


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Mountain Dwellings, Copenhague
Typologies Collective Housing
City Copenhagen
Photographer Dragor Luftfoto Jens Markus Lindhe Ulrik Jantzen Jakob Boserup Ole Malling
The new city section of Ørestad, a strip of 310 hectares developed mainly for residential and tertiary uses, is just ten minutes by public transport from the center of Copenhagen. Also conveniently located close to the airport, Ørestad grows on either side of the highway that joins Denmark and Sweden. Over the coming twenty years the population in this area is expected to reach 20.000, offering 80.000 jobs and 20.000 places in high schools and universities. Compared to the neighboring residential areas, this recently developed section has a greater density and a greater presence of collective housing, with different types of use: normal rent, public rent, private ownership or co-op. The two adjacent sites contain two projects designed by the studio PLOT, currently divided into the offices BIG and JDS.
Per request of the client, the program of the Mountain is 2/3 parking and 1/3 living, covering an area of 33,000 square meters. Eight diagrams of the process explain how the final form was reached, from the decision to bring the whole program together in one volume, passing through the sloping shape of this volume, its adaptation to the floor plan of the neighboring VM House, the creation of an urban space delimited by broken facades, the ramp system towards the interior of the parking, the 10 x 10 meter grid that organizes the dwellings and, finally, their staggered arrangement so that each home is below the terrace of the one above.
The parking needs to be connected to the street, and the homes – eighty units in total –require sunlight, fresh air and views, so all the apartments have roof gardens facing the sun, spectacular views and parking within the building. The Mountain thus offers the best of two worlds: closeness to the busy city life in the center of Copenhagen, and the peace of suburban life. The parking, with room for 480 vehicles, has an elevator that moves along the inner walls of the building, and at some points the ceiling height reaches 16 meters. The north and west facades are covered by perforated aluminum plates, which let air and light into the parking area, and the remaining facades and the roof are clad in wood. The holes in the facade form a huge reproduction of Mount Everest. At nighttime the facade will be lit from the inside and appear as a photo negative in different hues as each floor in the parking area has different colors.
Technical Info ShowHide technical info
Høpfner A/S
BIG-Bjarke Ingels Group
Socio responsable Partner in charge: Bjarke Ingels
Jefe de proyecto Project leader: Finn Nørkjær
Mánager de proyecto Project manager: Jan Borgstrøm
Jefe de obras Construction manager: Henrick Poulsen
Arquitecto responsable Project architect: Jacob Lange
Equipo de proyecto Project team: Annette Jensen, Dariusz Bojarski, Dennis Rasmussen, Eva Hviid-Nielsen, Joao Vieira Costa, Jørn Jensen, Karsten V. Vestergaard, Karsten Hammer Hansen, Leon Rost, Louise Steffensen, Malte Rosenquist, Mia Frederiksen, Ole Elkjær-Larsen, Ole Nannberg, Roberto Rosales Salazar, Rong Bin, Sophus Søbye, Søren Lambertsen, Wataru Tanaka
Moe & Brødsgaard (estructuras structural engineering); Freddy Madsen Rådgivende (obra civil civil engineering); JDS Architects; SLA
Dragør Luftfoto; Jens Markus Lindhe; Ulrik Jantzen; Jakob Boserup; Ole Malling
Included Tags:
BIG / Bjarke Ingels Group Bjarke Ingels Collective Copenhagen Denmark Dragor Luftfoto Housing Jakob Boserup Jens Markus Lindhe Ole Malling Ulrik Jantzen Wood
Waste Treatment Plant, Copenhague
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group Denmark The new building is located in an industrial area just outside the city center, which will harbor new recreational activities. The plant for waste treatment becomes an exemplary model in the field of residue management and energy production, as well
Tórshavn Education Center,Tórshavn
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group Faroe Islands The new Education Center is located on a hillside, 100 meters above sea level, outside Torshavn, the islands' capital. It is the largest education building in the history of the Faroe Islands, and is meant to serve as base for the coordination and de
Energy Mansion Tower, Shenzhen
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group China The tropical climate of Shenzhen calls for a new approach to designing office buildings. The Energy Mansion Tower project design reacts to the need to create comfortable working spaces in this specific climate and, at the same time, to reduce energy
Superkilen Urban Park, Copnhague
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group Denmark Located in the center of Nørrebro, north of the Danish capital, Superkilen is an urban park that exhibits the cultural diversity of the area with a contemporary language. The team of Bjarke Ingels, in collaboration with the Danish group of artists Su
Danish Pavilion, Shanghai
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group China The name of the Danish Pavilion at Expo 2010 in Shanghai, 'Welfairytales', is a play on words that makes reference respectively to the motto of the Expo ('Better city, better life') and to the tales by Hans Christian Andersen, the most well-known Dan
Marsk Tower in Hjemsted
BIG / Bjarke Ingels Group Denmark In the Wadden Sea National Park, a UNESCO World Heritage Site located to the south of the peninsula of Jutland, this sculptural observation tower stands 25 meters tall and is a tourist attraction. With an elevator tucked into the core, it was built w
West 57th Street, New York
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group United States New York is becoming a greener and more welcoming city. The transformation of the Hudson riverfront, the High Line linear park, the pedestrianization of Broadway and the construction of thousands of kilometers of bicycle lanes are a few of the latest
Kistefos Museum, Jevnaker
BIG / Bjarke Ingels Group Norway Situated in Jevnaker, a small town some 75 kilometers from Oslo, Kistefos is a collection of three landscapes that overlap and intertwine: a natural one of rivers, waterfalls, islands, canyons, and forests; an industrial one of mills, factories, ware
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group United States Located at the intersection of the High Line and Hudson Boulevard on Manhattan's new western frontier, the project extends the green space of the old train tracks in a spiraling motion towards the sky. The 306-meter-tall construction is a unique hybr
Noma Restaurant in Copenhagen
BIG / Bjarke Ingels Group Denmark Created by the Danish chef René Redzepi, Noma is considered one of the top restaurants in the world. The original Noma closed in late 2016 with the idea of opening anew on the northern tip of Christianshavns Vold – the remains of a rampart which was
Serpentine Pavilion 2016
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group United Kingdom In summer of 2016 came BIG's turn to build the temporary pavilion of the Serpentine Gallery, the popular art institution located in London's Kensington Gardens. The project was conceived as a provocative installation combining what are often perceive
Harbor Pool and Winter Baths, Tórshvan
BIG / Bjarke Ingels Group BIG / Bjarke Ingels Group Denmark The Copenhagen Harbor is in the midst of a transformation from industrial port and traffic hub to being the cultural and social center of the city. 'Blue Plan' is the name of the program in progress along its 42 kilometers of docks, a redevelopment a
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AV Monografías 162 (pages 36-41) BIG Open the digital publication
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New NSF IUCRC planning grant at Wayne State tackling electrification and infrastructure research for autonomous and connected vehicles
Wayne State University has announced the formation of the Center for Electric, Connected and Autonomous Technologies for Mobility (eCAT), a National Science Foundation (NSF) Industry-University Cooperative Research Center (IUCRC) tasked with developing sustainable mobility technologies such as electrification, smart infrastructure, and resilient edge computing systems for autonomous driving.
The IUCRC program supports multiuniversity, industry-sponsored research that allows companies to acquire new technologies. Wayne State partnered with the University of North Texas and Clarkson University to establish eCAT, composed of a diverse group of scientists interested in closing a gap in synergistic research pertaining to electric vehicle design, autonomous systems, V2X communications and real-time edge computing.
"While autonomous vehicle companies focus on prototyping and manufacturing driverless cars, electrification and connectivity technologies can upgrade the industry by allowing vehicles to communicate with each other and with the smart infrastructure to achieve better safety, reliability, infotainment and security with less emission," said Weisong Shi, professor of computer science and the center's director.
Zheng Dong, assistant professor of computer science, leads the education and workforce development aspect of eCAT and serves as the Wayne State site co-director. Co-principal investigators on the planning grant include Jerry Ku, associate professor of mechanical engineering; Caisheng Wang, professor of electrical and computer engineering; and Gene Liao, professor of engineering technology.
In addition to the faculty members, industry liaisons and student research teams from Wayne State and its two partner universities, eCAT also benefits from an industrial advisory board that identifies potential projects. The group comprises high-level executives from OEMs, tier-1 suppliers, startups and IT companies.
"By leveraging the broad range of expertise and enthusiastic support from regional and national automobile companies, next-generation edge computing platforms, leading telecom operators, nonprofit organizations, and government agencies in Michigan, we aim to bring significant contributions to the eCAT," said Shi.
According to the NSF, industry and government organizations pay membership fees to a consortium in order to collectively envision and fund research. At least 90% of member funds are allocated to the direct costs of these fundamental, pre-competitive research projects.
Visit ecat.center to learn more about the Center for Electric, Connected and Autonomous Technologies for Mobility.
The award number for this National Science Foundation grant is 2113817.
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Baku Inn Hotel Staff keeps its status by providing high quality service and along with that is working to improve their professional level. The hotel has 7 floors and 42 standard rooms and suites. At Baku Inn Hotel we have the perfect venue for any kind of meeting from a formal conference to a social function, business incentive or media launch.
"Grand Hotel Europe" is one of the important symbols of the city of Baku since 1997 and is one of the first Five star hotels Baku, Azerbaijan. Business class hotel is a few minutes' drive from main business, government agencies and center of the capital and is located next to Heydar Aliyev Sport Complex. The hotel is situated 2 km from the Old City and Fountain square.
Sapphire Inn Hotel is located in the very centre of the city, which will allow you to see the sights of the city, visit trade and business centres. For a long-distance travel, we are ready to provide you with car rental or taxi order services. We are also ready to provide individual parking service.


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[Methionine synthase] reductase, or Methionine synthase reductase, encoded by the gene MTRR, is an enzyme that is responsible for the reduction of methionine synthase inside human body. This enzyme is crucial for maintaining the one carbon metabolism, specifically the folate cycle. The enzyme employs one coenzyme, flavoprotein.

Mechanism
MTRR works by catalyzing the following chemical reaction:

2 [methionine synthase]-methylcob(I)alamin + 2 S-adenosylhomocysteine + NADP  2 [methionine synthase]-cob(II)alamin + NADPH + H + 2 S-adenosyl-L-methionine

The 3 products of this enzyme are methionine synthase-methylcob(I)alamin, S-adenosylhomocysteine, and NADP, whereas its 4 substrates are methionine synthase-cob(II)alamin, NADPH, H, and S-adenosyl-L-methionine.

Physiologically speaking, one crucial enzyme participated in the folate cycle is methionine synthase, which incorporated a coenzyme, cobalamin, also known as Vitamin B12. The coenzyme utilizes its cofactor, cobalt to catalyze the transferring function, in which the cobalt will switch between having 1 or 3 valence electrons, dubbed cob(I)alamin, and cob(III)alamin.

Over time, the cob(I)alamin cofactor of methionine synthase becomes oxidized to cob(II)alamin, rendering the enzyme inactive. Therefore, regeneration of the enzyme is necessary. Regeneration requires reductive methylation via a reaction catalyzed by (methionine synthase) reductase in which S-adenosylmethionine is utilized as a methyl donor, reducing cob(II)alamin to cob(I)alamin.

Systematic naming
This enzyme belongs to the family of oxidoreductases, to be specific those oxidizing metal ion with NAD+ or NADP+ as acceptor.  The systematic name of this enzyme class is [methionine synthase]-methylcob(I)alamin,S-adenosylhomocysteine:NADP+ oxidoreductase. Other names in common use include methionine synthase cob(II)alamin reductase (methylating), methionine synthase reductase, [methionine synthase]-cobalamin methyltransferase (cob(II)alamin, and reducing).

References

EC 1.16.1
NADPH-dependent enzymes
Enzymes of unknown structure


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The Best Ways of Doing Academic (Qualitative and Quantitative) Research
April 1, 2018 / admin / 0 Comments
Approaching academic research, one can divide the ways of establishing a methodology for the research into two broad categories, in which there are many subcategories. These broad categories are those of qualitative and quantitative research. In qualitative research, there is more room for the researcher or academic to establish the subjectivity of their reportage, regarding the distance that is established between the researcher and the subject. For example, someone doing qualitative research may present a case study of four unemployed mothers, in order to provide research about the need for welfare reform. They have interviewed and presented these cases through their own subjective lens. Quantitative research, on the other hand, is more stringent regarding reliability and validity, and more likely to include numbers and statistics to prove or disprove an academic hypothesis. For example, someone doing quantitative research may research government unemployment records for a decade, and make a series of charts showing changes in health insurance coverage vs. changes in work status. "Flexible research designs are much more difficult to pin down than fixed designs. This is in part because it is only in recent years that researchers have given consideration to the design issues which they raise. Previously there had been a tradition in the disciplines of social anthropology of an apprenticeship model". It is possible for an academic researcher to include elements of both qualitative and quantitative research in their methodology, which is called a mixed method.
As noted, qualitative and quantitative research categories are broad, and each contain many sub-categories and the possibility of mixed methodologies. From a perspective of ease and clarity, quantitative experiments are often more cost-effective, and seek to generally show the attitudes and beliefs of a given population, or segment of the population, regarding an established issue. Many academic researchers use survey research to find these attitudes and beliefs, because it introduces the subject of the mixed methodology when these survey results are presented in graph and chart forms. "Surveys can be classified by their method of data collection. Mail, telephone interview, and in-person interview surveys are the most common. Extracting data from samples of medical and other records is also frequently done. In newer methods of data collection, information is entered directly into computers". In todays world, academic researchers may also conduct surveys over the internet or in instant message programs.
Conducting a mixed methodology research project, an academic researcher may also want to go the route of looking at conclusions drawn from existing research. This can be a qualitative or quantitative approach; the key is that the academic researcher uses the studies and research of others that is established, to make their own points. This type of method is sometimes called a meta-analysis, but in reality, it is more like an extended sort of literature review. The researcher supports or dissents regarding the points of other researchers, based on a past precedent.
Although there are many ways of approaching academic research, the two most common categories for research methodologies are qualitative and quantitative. Research can, however, have elements of both categories, and still be effective. Quantitative research may be higher in terms of reliability and validity for academic researchers, but may not bring across the human element of the research to the reader as well as qualitative research. This latter form of research, while presenting a more human face, may also be construed by the reader as being too subjective. In establishing a research methodology, the adept academic researcher may pick and choose from both quantitative and qualitative elements.
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Two of the country's biggest celebrity personalities will captain teams of celebrities in a series of sporting challenges. Top comedian John Bishop and two-time Olympic champion Sebastian Coe will lead their teams in events including rhythmic gymnastics, track cycling and swimming, all to raise money for Sport Relief.
Coe won gold in the 1500m, and silver in the 800m, at both the 1980 and 1984 Olympics and many will believe he has the edge over Bishop. However, the Liverpudlian comedian completed a five-day challenge to cycle, row and run the 290 miles from Paris to London in 2012 in aid of Sport Relief.
The series of challenges are set to take place at Queen Elizabeth Olympic Park as part of the Sport Relief Night of TV on Friday 21 March.
Champions Speakers has a host of stars from the world of sport and entertainment available for your event. Browse through to find the perfect after dinner speaker for you.